Sentences with gene / disease entities

Legend: GENE/PROTEIN CHEMICAL DISEASE SPECIES CELLINE

Human erythrocyte carbonic anhydrase B and C in chronic obstructive lung disease . - pubmed
The levels of carbonic anhydrase B and C isozymes in human red cells were determined using a quantitative immunological technique in patients with chronic obstructive lung disease . - pubmed
The produced quantity of lecithinase does not affect the toxicity of strains upon oral infection of the animals experimented . - pubmed
Abnormal bleeding is the key to early diagnosis , and the frequent use of sensitive HCG assays is the key to proper followup . - pubmed
Spontaneous elimination of HCG from the circulation following moler pregnancy , as indicated by sensitive assay , would predict a benign postmolar course ; no patient in the current series who once achieved undetectable levels of HCG developed malignant trophoblastic disease . - pubmed
The ability of the human interleukin-1 receptor antagonist , IL-1ra , to inhibit aerosolized antigen - induced airway hyperreactivity to i.v . - pubmed
In conclusion , IL-1ra inhibited antigen - induced airway hyperreactivity to i.v . - pubmed
substance P and bronchoalveolar lavage fluid inflammatory leukocyte influx in the guinea pig , in a time - dependent manner , suggesting that cytokines , such as IL-1 , may contribute to the pathophysiology surrounding this pulmonary anaphylaxis model . - pubmed
Interferon therapy for chronic NANB hepatitis . - pubmed
Characterization of keratinocyte plasminogen activator inhibitors and demonstration of the prevention of pemphigus IgG - induced acantholysis by a purified plasminogen activator inhibitor . - pubmed
Following only 15 min of ischemia , apical membrane enrichment of NaK - ATPase , normally a basolateral membrane ( BLM ) enzyme , had increased ( 1.6 + /- 0.6 vs. 2.9 + /- 1.2 , P less than 0.01 ) . - pubmed
Following ischemic injury ( 50 min ) , LAP staining could be seen within the cell and along the BLM . - pubmed
With cellular recovery from ischemic injury ( 5 days ) , LAP was again only visualized in the apical membrane . - pubmed
[ Plasma cholecystokinin level in chronic pancreatitis ] . - pubmed
Thus , in chronic pancreatitis ( cP ) , which leads to a decrease of digestive enzyme secretion , increases in plasma CCK may be postulated . - pubmed
H1 receptor antagonist treatment of chronic rhinitis . - pubmed
In patients with chronic rhinitis , H1 receptor antagonists play an important role in relieving the symptoms of sneezing , itching , and rhinorrhea . - pubmed
The proteolysis caused by purified calpain II was similar to proteolysis occurring during the formation of several experimental cataracts in rodents ; this suggested that the enzyme may play a role in cataract formation . - pubmed
Elevated serum follicle - stimulating hormone ( FSH ) levels and azoospermia were seen in all male patients after completion of induction and consolidation therapy as a result of germ cell and stem cell loss . - pubmed
Significance of elevated urinary N - acetyl - beta - D - glucosaminidase activity in chronic cadmium poisoning . - pubmed
N - Acetyl - beta - D - glucosaminidase ( NAG ) activity and beta 2 - microglobulin ( beta 2 - m ) concentration were measured in the urine of inhabitants of a cadmium - polluted area ( Cd ) , including patients with , or suspected , " itai - itai " disease and control subjects . - pubmed
Urinary NAG activity thus represents another useful indicator of renal tubular damage caused by Cd poisoning since the mechanisms for the excretion of NAG and beta 2 - m into urine are thought to be different . - pubmed
Expression of abl and other oncogenes is independent of metastatic potential in Abelson virus - transformed malignant murine large cell lymphoma . - pubmed
Analysis of the susceptibility of the transforming activities of lymphocyte - neoplasm DNAs to digestion with restriction endonucleases indicated that the same or closely related transforming genes were activated in independent neoplasms representative of the same stage of normal cell differentiation . - pubmed
The unfractionated extract and the fraction bound by Concanavalin A - Sepharose had similar ability to detect specific IgG in sera from patients with aspergillosis . - pubmed
An enzyme - linked immunosorbent assay for urinary albumin in patients with insulin - dependent diabetes mellitus . - pubmed
In this report , we developed an enzyme - linked immunosorbent assay ( ELISA ) for the measurement of urinary albumin ( UA ) and examined UA in 38 patients with insulin - dependent diabetes mellitus ( IDDM ) . - pubmed
the urinary protein of the cases with microalbuminuria consisted mainly of albumin , and in the case of nephropathy , an IgG band was also detected . - pubmed
Acute renal failure with ACE inhibition in aortic coarctation . - pubmed
The neurochemistry of vomiting involves serotonin and serotonin S3 receptors . - pubmed
Muscle fiber atrophy in leg muscles after botulinum toxin type A treatment of cervical dystonia . - pubmed
To further study possible distant effects of repeated BTX - A injections , we obtained percutaneous muscle biopsies of the vastus lateralis muscle from 11 patients with cervical dystonia . - pubmed
We postulate that the observed atrophy is due to distant effects of botulinum toxin causing progressive denervation - like changes in non - treated muscle . - pubmed
Adenoviral E1A - associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13 ) . - pubmed
We identify here that the p300 gene is fused to the MLL gene and that in - frame MLL - p300 fusion protein is generated in acute myeloid leukemia ( AML ) with t(11 ; 22)(q23 ; q13 ) . - pubmed
These findings suggest that the basis for the leukemogenesis of t(11 ; 22)-AML is the inability of p300 to regulate cell - cycle and cell differentiation after fusion with MLL . - pubmed
Prospective study of calcium channel blocker use , cardiovascular disease , and total mortality among hypertensive women : the Nurses ' Health Study . - pubmed
BACKGROUND : In several observational studies , patients prescribed calcium channel blockers had higher risks of cardiovascular diseases and mortality than those prescribed other antihypertensive medications . - pubmed
Women prescribed calcium channel blockers had a higher prevalence of ischemic heart disease . - pubmed
An association between calcium channel blocker use and myocardial infarction was apparent among women who had ever smoked cigarettes ( covariate - adjusted RR , 1.81 ; 95 % CI , 1.20 to 2.72 ) but not among never - smokers ( RR , 0.94 ; 95 % CI , 0.48 to 1.84 ) . - pubmed
CONCLUSIONS : In analyses adjusted only for age , we found a significant elevation in RR of total myocardial infarction among women who used calcium channel blockers compared with those who did not . - pubmed
The p52 / p65 heterodimer formed in the nucleus , bound specifically to the promoter of the tumor suppressor protein p53 , effecting a 25 to 30 - fold increase in the level of this protein . - pubmed
Analysis of gene - environment interaction in coronary artery disease : lipoprotein lipase and smoking as examples . - pubmed
Results from a prospective study on CAD risk in healthy middle - aged men show that the risk associated with the LPL - D9N variant , which has a modest effect on plasma triglyceride levels , is enhanced up to 10 fold , but only in men who smoke . - pubmed
The proposed mechanism for this LPL : smoking interaction on CAD risk is the subject of this review . - pubmed
Telomerase activity and hTERT mRNA in development and progression of adenoma to colorectal cancer . - pubmed
Telomerase activity and hTERT mRNA expression are upregulated in colorectal cancer . - pubmed
We examined telomerase activity by the fluorescence - based telomeric repeat amplification protocol method and analyzed the level of hTERT mRNA by real - time polymerase chain reaction in 74 surgically obtained neoplasms from 29 patients . - pubmed
These results suggest that telomerase activation occurs during the progression from low - grade to high - grade dysplasia in adenomas and increases steadily with the progression of the degree of dysplasia and invasion during colorectal carcinogenesis , and that hTERT mRNA expression is a feature of the late stage development of colorectal cancer . - pubmed
Through a genome - wide cDNA microarray , we identified that the paternally expressed gene 10 ( PEG10 ) was highly expressed in a great majority of hepatocellular carcinomas , although its expression was absent in normal liver cells . - pubmed
Exogenous expression of PEG10 conferred oncogenic activity and transfection of hepatoma cells with antisense S - oligonucleotides suppressing PEG10 resulted in their growth inhibition . - pubmed
These findings suggested that development of drug(s ) inhibiting PEG10 activity could be a novel approach for the treatment of hepatocellular carcinomas . - pubmed
Stress - induced release of HSC70 from human tumors . - pubmed
These findings indicate that HSC70 can be actively released from tumor cells and is indicative of a previously unknown mechanism by which immune modulators stimulate the release of intracellular HSC70 . - pubmed
This mechanism may account for the potent chaperokine activity of heat shock proteins recently observed during heat shock protein - based immunotherapy against a variety of cancers . - pubmed
Corticotropin and cortisone ; dosage and ratio of intramuscular and intravenous corticotropin ( ACTH ) and oral cortisone in treatment of certain dermatoses . - pubmed
Haemoglobin E in Burmese ; two cases of haemoglobin E disease . - pubmed
2 CASES OF THE NEONATAL FORM OF GENERALIZED CONGENITAL CYTOMEGALIC DISEASE ] . - pubmed
LPAM ( alpha 4 beta 7 integrin ) is an important homing integrin on alloreactive T cells in the development of intestinal graft - versus - host disease . - pubmed
We conclude that the alpha ( 4 ) beta ( 7 ) integrin is important for the invasion of alloreactive donor T cells into the gut and the subsequent development of intestinal GVHD and overall GVHD morbidity and mortality . - pubmed
UNLABELLED : Levels of some markers of coagulation and platelet activation such as prothrombin fragment 1 + 2 ( F1 + 2 ) thrombin - antithrombin complex ( TAT ) and von Willebrand factor ( vWF ) , are related to outcome in non ST - segment elevation acute coronary syndrome ( NSTEACS ) . - pubmed
AIM : To study changes of markers of coagulation and platelet activation during short term use of ticlopidine and clopidogrel in NSTEACS patients treated with aspirin and antithrombin . - pubmed
CONCLUSION : Short term use of ticlopidine in patients with NSTEACS treated with aspirin and unfractionated heparin was associated with lower levels of TAT and fibrinogen ( relative to control group ) on day 14 . - pubmed
Both ticlopidine and clopidogrel used in regimes with loading doses in NSTEACS patients treated with aspirin and antithrombin prevented acute phase elevation of vWF . - pubmed
Kinase Suppressor of Ras1 ( KSR1 ) functions as a positive modulator of Ras - dependent signaling either upstream of or parallel to Raf-1 , and pharmacologic inactivation of KSR1 may serve as a treatment for Rasdriven malignancies such as pancreatic cancer ( Xing , H. R. , Cordon - Cardo , C. , Deng , X. , Tong , W. , Campodonico , L. , Fuks , Z. , and Kolesnick , R. ( 2003 ) Nat . - pubmed
Preeclampsia and the C282Y mutation in the hemochromatosis ( HFE ) gene . - pubmed
PURPOSE : Muscle insulin resistance is characterized by the inability of a normal insulin concentration to produce a favorable rate of glucose uptake . - pubmed
METHODS : A review of the relative research from my laboratory and the scientific literature was performed to obtain information on the muscle insulin resistance of the obese Zucker rat and its response to exercise training . - pubmed
RESULTS : The insulin resistance of the obese Zucker rat results from defects in the insulin signaling cascade , which limits translocation of the glucose transporter GLUT4 to the plasma membrane upon insulin binding to its receptor . - pubmed
Exercise training improves the muscle insulin resistance of obese Zucker rat but does not correct the defects in insulin signaling or GLUT4 translocation . - pubmed
All patients had cerebrospinal fluid pleocytosis and WNV - specific IgM in the cerebrospinal fluid and/or serum . - pubmed
Urinary zinc excretion and serum insulin were significantly higher in the same group , although the insulinemia and the parameters of zinc nutritional status were not significantly correlated . - pubmed
PpGalec , a tandem repeat galectin expressed in the midgut of the sandfly Phlebotomus papatasi , is used by Leishmania major as a receptor for mediating specific binding to the insect midgut , an event crucial for parasite survival , and accounts for species - specific vector competence for the most widely distributed form of cutaneous leishmaniasis in the Old World . - pubmed
Tissue transglutaminase and celiac disease . - pubmed
Effects of histone deacetylase inhibitor FR901228 on the expression level of telomerase reverse transcriptase in oral cancer . - pubmed
We speculated whether or not the expression level of telomerase reverse transcriptase ( hTERT ) would be modulated by agents targeting epigenetics in oral cancer cell lines . - pubmed
In the present study , the epigenetic effects of the histone deacetylase ( HDAC ) inhibitor FR901228 on hTERT transcription in oral cancer cell lines were analyzed by RT - PCR . - pubmed
We performed indirect genetic association studies of SRD5A1 and SRD5A2 and the dihydrotestosterone / testosterone ratio that reflects the activity of 5alpha - reductase in 57 males with type 2 diabetes . - pubmed
Virus - specific CD8 + T cell responses play an important role in the natural course of infection ; however , the impact of certain CD8 + T cell responses in determining clinical outcome has not been fully defined . - pubmed
However , the finding is especially significant because HLA - B27 has also been shown to have a protective role in HIV infection . - pubmed
In conclusion , our results suggest a dominant role of HLA - B27 in mediating spontaneous viral clearance as well as viral evolution in HCV infection and mechanistically link both associations to a dominant novel CD8 + T cell epitope . - pubmed
Manganese superoxide dismutase ( Mn - SOD ) gene polymorphisms in urolithiasis . - pubmed
Polymorphism in manganese superoxide dismutase gene ( Mn - SOD ) is a new approach to identify its probable association with urolithiasis . - pubmed
A valine ( Val ) to alanine ( Ala ) substitution at amino acid 16 , occurring in the mitochondrial targeting sequence of the MnSOD gene , has been associated with an increase in urolithiasis risk . - pubmed
This study was conducted to investigate the association of MnSOD gene polymorphism with the risk of urolithiasis . - pubmed
MnSOD genotype determination may provide a tool to identify individuals who are at risk of urolithiasis . - pubmed
The assessment of diabetes compensation is based on glycated haemoglobin , and glycated albumin is also recommended in certain cases . - pubmed
Deciding on the therapy ( oral antidiabetic drugs vs. insulin therapy or a combination of both ) is based on diabetic care standards ; cooperation between the diabetologist and the dialysis doctor is desirable . - pubmed
The purpose of this study was to determine whether oral EM could improve the periprosthetic tissue profiles and reduce serum cytokine production in AL patients who are candidates for surgical revision . - pubmed
Our results demonstrate that oral EM reduces the inflammation of periprosthetic tissues , as manifested by the reduction of the numbers of infiltrating cells , CD68 + macrophages , RANKL+ cells , and TRAP+ cells . - pubmed
Dual oral antiplatelet therapy with aspirin and oral ADP - receptor antagonists , such as clopidogrel , has been the standard choice for prevention of ischemic events in patients with acute coronary syndrome and in those undergoing percutaneous coronary intervention . - pubmed
Cangrelor is a reversible , potent , competitive inhibitor of the ADP P2Y ( 12 ) receptor that is administered intravenously and rapidly achieves near complete inhibition of ADP - induced platelet aggregation . - pubmed
Despite an abundance of data describing expression of genes in the Candida albicans ALS ( agglutinin - like sequence ) gene family , little is known about the production of Als proteins on individual cells , their spatial localization or stability . - pubmed
Development of an ErbB - overexpressing A-431 optical reporting tumor xenograft model to assess targeted photodynamic therapy regimens . - pubmed
To better assess the efficacy of erbB - targeted therapies , it would help to have optical reporting human tumor xenograft models that abundantly express erbB receptors . - pubmed
A GFP / luciferase clone , A-431 / D4 , and an RFP / luciferase clone , A-431 / G4 , were obtained that exhibit erbB1 expression levels and tumor growth kinetics similar to the parental cells . - pubmed
To demonstrate the utility of the optical reporting clones , A-431 / G4 tumors were grown subcutaneously in nude mice and treated with vascular - targeted photodynamic therapy ( PDT ) , which targets the angiogenic consequences of erbB signaling . - pubmed
A-431 / D4 and A-431 / G4 optical reporting tumor models should also prove useful for assessing therapies that directly target the erbB1 receptor . - pubmed
Genetic revelations charge APOL1 variants with kidney disease susceptibility . - pubmed
Our data suggest that these tumors share a common genomic program that includes inactivation of a master regulator of the p53 and Rb pathways , CDKN2A / B , and activation of FGFR4 , Ras , and Hedgehog ( Hh ) signaling . - pubmed
The CDKN2A / B tumor suppressor is deleted in most patient samples . - pubmed
FGFR4 , which encodes a receptor tyrosine kinase , is activated in 20 % of tumors , predominantly by amplification of mutant , activating FGFR4 alleles . - pubmed
We also identified intragenic deletions affecting NF1 , a tumor suppressor and inhibitor of Ras , in 15 % of tumor samples . - pubmed
Deletion of NF1 and the presence of activating Ras mutations ( in 42 % of patients ) were mutually exclusive , suggesting NF1 loss is an alternative and potentially common mechanism of Ras activation in ERMS . - pubmed
The aim of the present study was to describe the effects of beta - blocker metoprolol monotherapy and combined with calcium channel inhibitor felodipin on digital microcirculation in primary Raynaud ' s syndrome . - pubmed
RESULTS AND CONCLUSIONS : Our investigation concludes that the concurrent administration of beta - blockers with calcium channel inhibitors positively reduces symptoms in patients suffering from Raynaud ' s syndrome . - pubmed
Upregulation of recepteur d'origine nantais tyrosine kinase and cell invasiveness via early growth response-1 in gastric cancer cells . - pubmed
Abnormal accumulation and activation of the recepteur d'origine nantais ( RON ) has been implicated in carcinogenesis of epithelial tumors . - pubmed
RON expression was induced by the tumor promoter , phorbol 12 - myristate 13 - acetate ( PMA ) , in gastric adenocarcinoma AGS cells . - pubmed
These results suggest that tumor promoter induces RON expression via Egr-1 , which , in turn , stimulates cell invasiveness in AGS cells . - pubmed
We previously reported that mice lacking surfactant protein A ( SP - A ) have increased airway hyperresponsiveness ( AHR ) during M pneumoniae infection versus wild - type mice mediated by TNF - alpha . - pubmed
Mast cells ( MCs ) have been implicated in AHR in asthma models and produce and respond to TNF - alpha . - pubmed
OBJECTIVE : Determine the contribution of MC / TNF interactions to AHR in airways lacking functional SP - A during Mp infection . - pubmed
METHODS : Bronchoalveolar lavage fluid was collected from healthy and asthmatic subjects to examine TNF - alpha levels and M pneumoniae positivity . - pubmed
RESULTS : Our findings indicate that high TNF - alpha levels correlate with M pneumoniae positivity in human asthmatic patients and that human SP - A inhibits M pneumoniae - stimulated transcription and release of TNF - alpha by MCs , implicating a protective role for SP - A. - pubmed
Using SP - A(-/-)Kit(W - sh / W - sh ) mice engrafted with TNF - alpha(-/- ) or TNF receptor ( TNF - R)(-/- ) MCs , we found that TNF - alpha activation of MCs through the TNF - R , but not MC - derived TNF - alpha , leads to augmented AHR during M pneumoniae infection when SP - A is absent . - pubmed
CONCLUSION : Our data highlight a previously unappreciated but vital role for MCs as secondary responders to TNF - alpha during the host response to pathogen infection . - pubmed
Effect of transcatheter renal arterial embolization combined with cryoablation on regulatory CD4+CD25 + T lymphocytes in the peripheral blood of patients with advanced renal carcinoma . - pubmed
OBJECTIVE : To analyze the effect of Argon - Helium cryosurgery ( AHCS ) combined with transcatheter renal arterial embolization ( TRAE ) on the differentiation of regulatory CD4 + CD25 + T cell ( Treg ) and its implication in patients with renal carcinoma . - pubmed
COX1 is largely constitutively expressed , whereas COX2 is induced at sites of inflammation and vascular injury . - pubmed
These observations have raised interest in the use of COX inhibitors and PGI ( 2 ) analogs in the management of pregnancy - associated and neonatal vascular disorders . - pubmed
Alabama birds also displayed lower inflammatory cytokine signaling and lower fever early in infection . - pubmed
Oxidized low - density lipoprotein ( ox - LDL ) is directly associated with chronic vascular inflammation . - pubmed
To understand whether thioredoxin1 ( Trx1 ) participates in an antiinflammatory defense mechanism in atherosclerosis , we investigated the effect of Trx1 on the expression of two adhesion molecules , vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) , in human umbilical vein endothelial cells ( HUVECs ) . - pubmed
These results suggest that Trx1 inherently suppresses VCAM-1 and ICAM-1 expression in vascular endothelia and may prevent the initiation of atherosclerosis by attenuating adhesion molecule expression . - pubmed
FokI polymorphism in the vitamin D receptor gene ( VDR ) and its association with lumbar spine pathologies in the Italian population : a case - control study . - pubmed
The association between VDR polymorphisms and spine disorders has been analyzed in different ethnic groups , focusing on the functional FokI polymorphism . - pubmed
The aims of this study were to evaluate , in the Italian white population , the VDR FokI polymorphism frequencies distribution in subjects with clearly defined lumbar spinal pathologies compared to asymptomatic controls and to analyze the interplay of genetic and conventional risk factors . - pubmed
In conclusion , the link we observed between VDR FokI variants and specific lumbar spine pathologies suggests that spinal tissue degeneration is influenced by the genetic background . - pubmed
Future studies should evaluate the signaling pathways involving alterations in VDR and influencing the development and/or progression of spine disorders . - pubmed
We find that gene expression patterns within early neoplasias are distinct from both normal and breast cancer patterns and identify a pattern of pro - oncogenic changes , including elevated transcription of ERBB2 , FOXA1 , and GATA3 at this early stage . - pubmed
Measurements of protein expression by immunohistochemistry on an independent set of early neoplasias confirms that ER pathway regulators FOXA1 and GATA3 , as well as ER itself , are consistently upregulated at this early stage . - pubmed
Therefore , the differential - binding profile for the six lineages could have implications in the immunopathology of Chagas ' disease , affecting the complex network of immune responses on which galectins mediate , thus providing linkage clues to the notion that different lineages may be related to different clinical forms of the disease . - pubmed
This study reported a case of an 11 - month - old male infant with mitochondrial disease characteristics and subclinical hypothyroidism ( a high thyrotropin level ) . - pubmed
This case adds to the growing literature of mitochondrial disorders caused by mitochondrial ATPase 6 mutations . - pubmed
Lymphocytotoxicity inhibition : a reliable method for HL - A typing of cultured cell lines . - pubmed
Despite normal or high total P-450 , in vivo drug metabolism was impaired in subjects with altered parenchyma , suggesting that other factors were limiting antipyrine elimination in liver disease . - pubmed
In a case of osteogenesis imperfecta with multiple fractures already from childhood , myelomatosis was diagnosed at the age of 52 years because of a serum M - component ( IgG , lambda ) , Bence Jones proteinuria , myeloma cells in the bone marrow , and osteolytic skeletal lesions . - pubmed
Scleroderma ( progressive systemic sclerosis ; PSS ) is a connective tissue disorder in which excessive collagen is deposited in the skin and internal organs . - pubmed
Results indicate that ( 1 ) the proliferative influence of serum of patients with PSS is not different from that of normal donors , ( 2 ) increased proliferation and procollagen gene expression are not linked in affected or unaffected dermal fibroblasts , and ( 3 ) affected PSS fibroblasts produce a stimulatory factor(s ) for procollagen gene expression to which they are differentially sensitive . - pubmed
Expression of the neuronal form of pp60c - src in neuroblastoma in relation to clinical stage and prognosis . - pubmed
The expression of the protooncogene c - src has been studied in specimens of childhood tumors with special reference to neuroblastoma and other tumors of neuronal origin . - pubmed
For comparison c - src gene expression was studied in seven neuroblastoma and neuroepithelioma cell lines . - pubmed
While pp60c - src was found in most tumors studied , the neuronal form was restricted to neuroblastomas ( 23 of 27 ) and retinoblastomas ( 3 of 3 ) and could not be detected in the other childhood tumors . - pubmed
A dominance of the neuronal form , pp60c - srcN , was exclusively found in the infant cases of neuroblastoma ( 9 of 12 ) , estimated to have good prognosis . - pubmed
These results indicate that pp60c - srcN might be a diagnostic marker in primitive childhood tumors . - pubmed
When expressed in higher amounts than pp60c - src , pp60c - srcN may be a positive prognostic marker in neuroblastoma , especially useful in the evaluation of infants . - pubmed
In addition , lack of pp60c - srcN seems to be incompatible with low stage neuroblastoma . - pubmed
To determine if increases in the target cell free intracellular Ca2 + concentration ( [ Ca2+]i ) are also important for cytotoxicity , we examined the effects of Ca2 + substitutes , promotors of Ca2 + influx ; and inhibitors of Ca2 + efflux on the cytolysis mediated by purified cytolysin . - pubmed
Ethacrynic acid , a potent inhibitor of glutathione S - transferases ( GST ) , has been shown to enhance the cytotoxicity of chlorambucil in drug resistant cell lines , but a definite mechanism has not been established . - pubmed
[ Experience with using automated insulin infusion systems in diabetes mellitus type 1 ] . - pubmed
Neurotoxicity of parathyroid hormone in uremia . - pubmed
The steady - state level of truncated myc RNAs in J558 was comparable to that in another plasma cell tumor line ( MPC-11 ) which harbors a translocated c - myc locus without an IAP element . - pubmed
Adenylate cyclase activity in kidney of partially nephrectomized uremic rats : decreased sensitivity to arginine - vasopressin in kidney medulla . - pubmed
Immunoglobulin E and A levels in atopic and anaphylactic children . - pubmed
IgE levels were high in both atopic and anaphylactic patients but higher in the atopic than in the anaphylactic group . - pubmed
A multiple - dose phase I trial of recombinant leukocyte A interferon in cancer patients . - pubmed
Eighty - one patients with a variety of refractory disseminated malignant neoplasms have been treated in the first multiple fixed - dose phase I trial of recombinant leukocyte A interferon ( IFL - rA ) . - pubmed
The toxic reactions seen with IFL - rA resembled those of nonrecombinant leukocyte interferon and included fever , chills , fatigue , anorexia , myalgia , headache , occasional nausea and vomiting , and dose - dependent reversible leukopenia and hepatic transaminase elevations . - pubmed
Serum haptoglobin as tumor marker . - pubmed
Interferon response in chronic myeloid leukaemia correlates with ABL / BCR expression : a preliminary study . - pubmed
alpha - Interferon ( IFN ) has been used to induce cytogenetic remission in chronic myeloid leukaemia ( CML ) , but there are few indicators to predict IFN response . - pubmed
The function and clinical significance of the newly discovered ABL / BCR mRNA has not been investigated for a correlation with CML prognosis or response to therapy . - pubmed
We have used a two - step reverse transcriptase polymerase chain reaction ( RT - PCR ) to detect the transcripts of the chimaeric genes BCR / ABL , ABL / BCR , as well as the normal ABL and BCR genes in 24 CML patients treated with IFN . - pubmed
However , 7/10 ABL / BCR mRNA positive patients achieved a major cytogenetic response to IFN ; but of the 13 ABL / BCR mRNA negative patients , only two achieved a major cytogenetic response ( P = 0.013 ) . - pubmed
A single parameter , oxygenated hemoglobin , can be used to quantify experimental irritant - induced inflammation . - pubmed
Rapid detection of transferrin receptor expression on glioma cell lines by using magnetic microspheres . - pubmed
A rapid method for detecting the presence of transferrin receptors ( TR ) on human glioblastoma - derived cell lines is presented . - pubmed
Seven established human glioblastoma - derived cell lines were assayed for the presence of TR with antibody - coated magnetic microspheres ( immunobeads ) . - pubmed
The immunobeads bound to glioblastoma cells in the presence of human anti - TR monoclonal antibodies to a significantly greater degree than to control cell lines ( P & lt ; 0.0001 ) . - pubmed
A 9L rat gliosarcoma cell line was used as a nonhuman control and did not demonstrate TR expression by either the immunobead assay or immunocytochemistry . - pubmed
First COMT inhibitor approved for Parkinson ' s disease . - pubmed
This relative resistance to HIV-1 infection did not extend to T cell line - adapted or syncytium - inducing ( SI ) primary viral isolates , was restricted by the envelope glycoprotein , and was associated with an increased production of the C - C chemokines RANTES , MIP-1alpha , and MIP-1beta . - pubmed
Resistance to infection and the high production of beta chemokines were characteristic of every CD4 + lymphocyte clone from the exposed - uninfected subjects . - pubmed
We have now identified the mechanism underlying this in vitro and in vivo resistance to infection : These individuals have inherited a homozygous 32 - bp nucleotide deletion ( delta32 ) within the gene encoding the coreceptor for primary NSI isolates of HIV-1 ( CCR5 ) . - pubmed
Twelve patients infected with the human immunodeficiency virus ( HIV ) and with CD4 cell counts below 100 cells / microliter received fluconazole daily ( 200 mg ; five patients ) or weekly ( 400 mg ; seven patients ) for fungal prophylaxis during a 6 - month period . - pubmed
METHODS : A DNA sequence encoding the ribozyme gene was incorporated into a eukaryotic expression vector ( pH beta Apr-1 neu ) and transfected into the human breast carcinoma cell line MCF-7 / Adr , which is resistant to adriamycin and expresses the MDR phenotype . - pubmed
CONCLUSIONS : We conclude that caspase-3 - mediated apoptosis causes extensive lymphocyte apoptosis in sepsis and may contribute to the impaired immune response that characterizes the disorder . - pubmed
Analgesic profile of the nicotinic acetylcholine receptor agonists , ( + ) - epibatidine and ABT-594 in models of persistent inflammatory and neuropathic pain . - pubmed
Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia . - pubmed
To elucidate the specific role of the TT genotype of MTHFR in the development of cerebral infarction with and without cognitive impairment , we determined the prevalence of hyperhomocyst ( e ) inemia and the C677 T genotypes of MTHFR in 143 patients with vascular dementia , 122 patients with cerebral infarction , and 217 healthy subjects matched for age and sex . - pubmed
Taken together , these findings indicate a possible role of MTHFR TT genotype combined with hyperhomocyst ( e ) inemia in the pathogenesis of vascular dementia . - pubmed
Similar to the relationship between homocystinuria due to severe MTHFR deficiency and severe cystathionine beta - synthase deficiency , the TT genotype of MTHFR in hyperhomocyst(e)inemic subjects is differentiated from the cases of the TT genotype without hyperhomocyst ( e ) inemia or hyperhomocyst(e)inemia without the TT genotype in the development of cerebrovascular disease . - pubmed
Platelet aggregation in response to ADP , collagen , and PGE1 was assessed , using optical aggregometry . - pubmed
Addition of PGE1 prior to addition of an agonist inhibited platelet aggregation in a concentration - dependent manner , whereas addition of PGE1 4 minutes after addition of ADP resulted in partial reversal of aggregation and fibrinogen binding . - pubmed
CONCLUSIONS AND CLINICAL RELEVANCE : A high concentration of sodium citrate in blood samples decreases plasma concentration of ionized calcium , resulting in reduced platelet aggregation and fibrinogen binding . - pubmed
Despite some expression of folate receptor alpha in human mesothelioma cells , internalization of methotrexate is predominantly carrier mediated . - pubmed
OBJECTIVE : As a response to a published report documenting some expression of folate receptor alpha in human mesothelioma , studies were carried out examining the role of this receptor versus that of the reduced folate carrier in the internalization of folate analogs in this neoplasm . - pubmed
Gene - expression analysis revealed prominent expression of the folate receptor in some but not all mesothelioma cell lines , and in only one case was expression of this receptor gene greater than expression of the reduced folate carrier gene . - pubmed
CONCLUSION : In view of the ongoing reduced folate carrier - mediated internalization that occurs in mesothelioma cells , these results would seem to argue against a role for the folate receptor in the internalization and cellular pharmacokinetics of methotrexate and other classic folate analogs in this neoplasm . - pubmed
Cytokines , especially TNF alpha , produced from macrophages / Kupffer cells , play a role in the induction of liver cell necrosis and apoptosis . - pubmed
It suggested that liver - associated T lymphocytes are involved in the inflammatory process associated with alcohol related liver injury through increased cytokine secretion ( TNF alpha ) . - pubmed
OBJECTIVES : To review the state of the art relating to protein S deficiency as a risk factor for thrombosis and to make recommendations regarding the use of protein S measurements in the assessment of thrombotic risk in individual patients and families . - pubmed
CONCLUSIONS : Consensus was reached on 16 recommendations for the use of protein S assays in the assessment of thrombotic risk in individuals and families . - pubmed
[ Anti - IgE ( Omalizumab ): a hope in the treatment of allergic diseases ] . - pubmed
Involvement of the anterior pretectal nucleus in the control of persistent pain : a behavioral and c - Fos expression study in the rat . - pubmed
In this study we used behavioral tests ( incisional pain and carrageenan - induced inflammatory pain ) and c - Fos expression changes to examine the involvement of the APtN in the control of persistent pain in rats . - pubmed
Low adiponectin levels predict type 2 diabetes in Mexican children . - pubmed
[ The expression of GABA - A receptor subunit alpha1 beta1 gamma2 mRNA in hepatic encephalopathic rats ] . - pubmed
The relationship between insulin resistance assessed by HOMA - IR and serum osteoprotegerin levels in obesity . - pubmed
AIM : We investigated the relationship between insulin resistance and serum osteoprotegerin ( OPG ) levels in healthy obese subjects and healthy lean controls . - pubmed
We used the homeostasis model assessment for insulin resistance ( HOMA - IR ) index as the index of insulin resistance . - pubmed
RESULTS : Obese subjects with increased insulin resistance ( Group III ) had lower OPG values than other groups ( 11.88+/-7.43 pg / ml , 16.39+/-6.39 pg / ml , 17.37+/-9.61 pg / ml , and 18.1+/-6.65 pg / ml , respectively ; Group I versus Group III p = 0.036 ; Group III versus Group IV p = 0.012 ) . - pubmed
In conclusion , insulin resistance in obesity is associated with decreased serum OPG levels and increased fibrinogen levels . - pubmed
The relationship between serum OPG levels and HOMA - IR may provide an insight into vascular endothelial dysfunction in obesity . - pubmed
Increased expression of plasma and cell surface co - stimulatory molecules CTLA-4 , CD28 and CD86 in adult patients with allergic asthma . - pubmed
To investigate whether there is altered expression and the clinical significance of soluble co - stimulatory molecules in asthmatic patients , plasma concentrations of sCTLA-4 , sCD28 , sCD80 and sCD86 in 51 adult allergic asthmatic adults with or without steroid treatment , and 35 sex- and age - matched control subjects were measured by enzyme - linked immunosorbent assay ( ELISA ) . - pubmed
Results showed that the plasma sCTLA-4 concentration was significantly higher in all asthmatic patients while sCD28 and sCD86 concentrations were significantly higher in steroid and non - steroid treated asthmatic patients , respectively , compared with control subjects ( all P & lt ; 0.01 ) . - pubmed
Significantly increased cell surface expression of CD28 but not CTLA-4 on PBMC was found in asthmatic patients compared with controls ( P & lt ; 0.05 ) . - pubmed
Serum total IgE concentration correlated positively and significantly with sCTLA-4 and sCD28 concentrations in allergic asthmatic patients ( both P & lt ; 0.05 ) . - pubmed
Osteoclasts from patients with autosomal dominant osteopetrosis type I caused by a T253I mutation in low - density lipoprotein receptor - related protein 5 are normal in vitro , but have decreased resorption capacity in vivo . - pubmed
Autosomal dominant osteopetrosis type I ( ADOI ) is presumably caused by gain - of - function mutations in the LRP5 gene . - pubmed
To investigate the effect of the T253I mutation in LRP5 on osteoclasts , we isolated CD14 + monocytes from ADOI patients and assessed their ability to generate osteoclasts when treated with RANKL and M - CSF compared to that of age- and sex - matched control osteoclasts . - pubmed
Cerebrotendinous xanthomatosis ( CTX ) is an autosomal recessive lipid storage disease caused by a deficiency of the mitochondrial enzyme 27 - sterol hydroxylase ( CYP27 ) . - pubmed
Volunteers were questioned about their bleeding history and the following tests were performed : complete blood count , prothrombin time / international normalized ratio , activated partial thromboplastin time , platelet function analysis , and platelet aggregation using standard turbidimetric methodology . - pubmed
The red - haired volunteers reported significantly more bruising , but there were no significant differences between the red - haired and dark - haired groups in hemoglobin concentration , platelet numbers , prothrombin time / international normalized ratio , or activated partial thromboplastin time . - pubmed
Previously , we reported that TTSS1 is involved in the cytotoxicity of the RIMD2210633 strain against HeLa cells . - pubmed
The cytotoxicity to HeLa cells was related to one of the newly identified secreted proteins encoded by VP1680 . - pubmed
Aberrant methylation of RASGRF2 and RASSF1A in human non - small cell lung cancer . - pubmed
RASSF1A , regarded as a TSG , has been extensively studied in lung cancer and other malignant tumors , whereas RASGRF2 has only been reported to possibly play a role in the pathogenesis of pancreatic cancer cell lines . - pubmed
The aims of our study were to i ) determine the methylation profile of RASGRF2 and ii ) compare the methylation profiles of RASGRF2 with RASSF1A in lung cancer . - pubmed
We examined RASGRF2 expression by reverse transcription PCR and aberrant methylation of RASGRF2 by methylation - specific PCR in lung cancer cell lines . - pubmed
Loss of RASGRF2 expression was presented in 36 % lung cancer cell lines while aberrant methylation of RASGRF2 was present in 30 % ( 3/10 ) non - small cell lung cancer ( NSCLC ) cell lines and in 25 % ( 1/4 ) small cell lung cancer ( SCLC ) cell lines . - pubmed
Among primary NSCLC , RASGRF2 and RASSF1A methylation was observed in 34 % ( 39/114 ) and 39 % ( 44/114 ) of cases respectively , while it was observed in only 7 % ( 4/57 ) and none of the corresponding non - malignant lung tissue . - pubmed
Frequent methylation and silencing of RASGRF2 in tumor cells may play an important role , different from that of RASSF1A , in the carcinogenesis of NSCLC . - pubmed
Of 632 women , aged 70 - 79 yr , 14.1 % of women were anemic ( hemoglobin & lt;120 g / L ) . - pubmed
An increase in loge selenium was associated with a reduced risk of anemia ( odds ratio per 1 SD increase = 0.63 , 95 % confidence interval = 0.47 - 0.84 ) , adjusting for age , education , chronic diseases , iron status , and serum interleukin-6 . - pubmed
IL-23 plays crucial roles in both immunity against pathogens and autoimmunity against self . - pubmed
In univariate analysis , leukocytes and CRP levels were associated with MVO , whereas pre - infarction angina and prior medication by aspirin or calcium channel antagonist appeared protective . - pubmed
Microvascular obstruction intensity positively correlated with baseline inflammation status assessed by C - reactive protein and leukocytes ( rho=0.43 and rho=0.44 ; p=0.003 ) , the peak of CK ( rho=0.56 ; p=0.01 ) or Troponin I ( rho=0.59 ; p=0.01 ) and negatively correlated with LVEF ( rho=-0.44 ; p=0.002 ) . - pubmed
tPA levels increased in FMF patients ( tPA levels of group 1 , 2 and 3 were 12.6 , 13.2 and 9.7 ng / ml , respectively ; p = 0.01 ) . - pubmed
Prolongation of PT and differences in tPA and P - selectin levels suggest that hypercoagulability may have a role in the etiopathogenesis of FMF . - pubmed
It may be possible to use PAI-1 as a marker for the attacks of FMF . - pubmed
CXCR5- and CCR7 - dependent lymphoid neogenesis in a murine model of chronic antigen - induced arthritis . - pubmed
The aim of this study was to establish a murine model of chronic arthritis in which the development of tertiary lymphoid tissue , a hallmark of human RA , is locally induced , and to characterize the roles of the homeostatic chemokine receptors CXCR5 and CCR7 in this process . - pubmed
Disease pathology was assessed up to 9 months in wild - type , CXCR5 - deficient , and CCR7 - deficient mice by determination of knee joint swelling and cellular and humoral immune responses , as well as by histologic analysis of arthritic knee joints . - pubmed
Analysis of the initiation and progression of AIA in wild - type , CXCR5-/- , and CCR7-/- mice revealed a reduction of acute inflammatory parameters in both knockout strains as well as significantly reduced joint destruction in CXCR5-/- mice . - pubmed
Cardiac troponin I as prognostic marker in heart failure patients discharged from emergency department . - pubmed
Despite evidence that cardiac troponin I ( cTnI ) identifies patients with advanced heart failure ( HF ) at risk of death , data on heterogeneous HF populations are scarce . - pubmed
Our purpose was to verify and analyze the prognostic role of cTnI in acute HF patients admitted to the emergency department . - pubmed
cTnI was detected in 45.5 % of HF patients . - pubmed
Viral and host correlates of serum resistin in simian AIDS . - pubmed
Resistin is an adipocytokine with a proposed dual role in metabolism and inflammation . - pubmed
This study utilizes the simian immunodeficiency virus ( SIV ) model of HIV / AIDS to investigate changes in serum resistin levels following dietary intervention and SIV infection and determine associations with measures of body composition and disease severity . - pubmed
Resistin levels , body composition ( n = 34 ) , and insulin resistance ( n = 16 ) were determined in healthy rhesus macaques . - pubmed
In healthy macaques consuming a standard diet , resistin levels correlated positively with total fat mass ( r = 0.49 ; p & lt ; 0.01 ) and tissue fat percent ( r = 0.53 ; p & lt ; 0.01 ) but failed to associate with measures of insulin resistance . - pubmed
Serum levels of MCP-1 and sTNF RII demonstrated no correlation with resistin in normal animals on a standard diet , while a significant positive correlation was observed following SIV infection ( r = 0.52 ; p & lt ; 0.0001 and r = 0.59 ; p & lt ; 0.0001 , respectively ) . - pubmed
Findings indicate a fundamental difference in the relationship between resistin and body composition following SIV infection and suggest that elevations in resistin parallel measures of disease severity including loss of body fat and viral replication . - pubmed
Recessive hereditary methemoglobinemia : two novel mutations in the NADH - cytochrome b5 reductase gene . - pubmed
Relation between degree of weight loss after bariatric surgery and reduction in albuminuria and C - reactive protein . - pubmed
Improvement in albuminuria and high - sensitivity C - reactive protein ( hs - CRP ) has also been reported . - pubmed
We investigated , at a weight control center in a community hospital setting , the relation between degree of surgical weight loss and reduction in the cardiovascular risk markers , albuminuria and hs - CRP . - pubmed
CONCLUSION : The results of our study have shown that obese adults experience a reduction in albuminuria and hs - CRP after bariatric surgery , with a greater reduction in hs - CRP observed with more surgical weight loss . - pubmed
STUDY DESIGN : To investigate if milk enzyme activities and the inflammatory interleukin 8 ( IL-8 ) level are increased in women with SCM , we measured sodium , potassium , NAGase , LDH , AcP , AP , and IL-8 in breastmilk samples collected at 2 months postpartum from 797 women in Guinea - Bissau , West Africa . - pubmed
BACKGROUND : Studies have suggested that vitamin D may be important for both insulin sensitivity and insulin secretion , and that supplementation with vitamin D may subsequently prevent development of type 2 diabetes . - pubmed
METHODS : Thirty - six subjects with type 2 diabetes , treated with metformin and bed - time insulin , were randomised to supplementation with cholecalciferol ( 40,000 IU per week ) versus placebo for 6 months . - pubmed
Estrogen receptor alpha ( ER alpha ) is a ligand - regulated transcription factor with a broad range of physiological functions and one of the most important classifiers in breast cancer . - pubmed
miR-22 overexpression leads to a reduction of ER alpha levels , at least in part by inducing mRNA degradation , and compromises estrogen signaling , as exemplified by its inhibitory impact on the ER alpha - dependent proliferation of breast cancer cells . - pubmed
Update on phase II studies of erythropoietin in acute myocardial infarction . - pubmed
Rationale and design of Exogenous erythroPoietin in Acute Myocardial Infarction : New Outlook aNd Dose Association Study ( EPAMINONDAS ) . - pubmed
Erythropoietin ( Epo ) is a hematopoietic hormone produced mainly by the kidneys in response to hypoxia . - pubmed
Exogenous erythroPoietin in Acute Myocardial Infarction : New Outlook aNd Dose Association Study ( EPAMINONDAS , EudraCTno . - pubmed
200500485386 ) is one of four ongoing randomized controlled trials , each testing the effects of Epo in & gt;or=100 patients with STEMI . - pubmed
EPAMINONDAS is a multicenter , prospective , double - blind , placebo - controlled , dose - finding study assessing intravenous moderate doses of human recombinant Epo ( epoietin - alpha , 100 or 200 IU / kg / die ) versus placebo , given on the first 3 days , in 102 patients with first ST - segment elevation myocardial infarction . - pubmed
The results of current phase II studies will help define the safety / efficacy profile of Epo for patients with STEMI . - pubmed
Functional autoantibodies against serpin E2 in rheumatoid arthritis . - pubmed
Levels of anti - serpin E2 autoantibodies in serum and synovial fluid from patients with RA , osteoarthritis ( OA ) , psoriatic arthritis , and ankylosing spondylitis , and/or from healthy individuals were assessed by enzyme - linked immunosorbent assay . - pubmed
Serpin E2 was overexpressed in RA synovial tissues as compared with OA synovial tissues . - pubmed
Significantly higher levels of anti - serpin E2 autoantibodies were present in samples of synovial fluid ( 28 % ) and serum ( 22 % ) from RA patients as compared with OA patients ( 0 and 6 % , respectively ) or with healthy individuals ( 6 % of sera ) . - pubmed
Most importantly , anti - serpin E2 autoantibodies isolated from RA sera reversed the inhibitory activity of serpin E2 by 70 % . - pubmed
Since anti - serpin E2 autoantibodies interfere with the inhibitory activity of serpin E2 toward serine proteases , they might facilitate the joint destruction in RA . - pubmed
Reduction of the activity of the purified lectin after oxidation by H2O2 , with remarkable fluorescence quenching , may suggest potential role for galectin-1 in free radical - induced , oxidative stress - mediated cardiovascular disorders . - pubmed
Expression and methylation status of the Syk gene in cervical carcinoma . - pubmed
Decrease or loss of Syk expression has been associated with a malignant phenotype and poor prognosis in a variety of cancers . - pubmed
This study aimed to determine the precise role of Syk in cervical cancer . - pubmed
METHODS : Methylation - specific PCR ( MSP ) and RT - PCR were utilized to analyze the methylation status and Syk mRNA expression in tissue samples from 20 normal controls , 50 CIN patients and 60 cervical cancer patients . - pubmed
RESULTS : Syk expression was detected in all 20 normal cervical tissues , as well as in all 18 CIN1 samples . - pubmed
Syk expression was found in 18 of 32 ( 56 % ) of CIN2/3 samples . - pubmed
CONCLUSION : The results indicate a potential link between the loss of Syk expression and cervical carcinogenesis . - pubmed
Metabolic syndrome criteria had the highest sensitivity for predicting fasting insulin ( 40 - 70 % ) , followed by uric acid ( 31 - 54 % ) , hsCRP ( 13 - 31 % ) , and HbA1c ( 7 - 21 % ) . - pubmed
Rho - kinase / nuclear factor - kappabeta / angiotensinogen axis in angiotensin II - induced renal injury . - pubmed
Glycosaminoglycan storage in neuroanatomical regions of mucopolysaccharidosis I dogs following intrathecal recombinant human iduronidase . - pubmed
Intrathecal ( IT ) recombinant human alpha - l - iduronidase ( rhIDU ) has been shown to reduce mean brain glycosaminoglycans ( GAGs ) to normal levels in mucopolysaccharidosis I ( MPS I ) dogs . - pubmed
[ Association of ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with cerebral infarction ] . - pubmed
OBJECTIVE : To study the association of ITGA9 gene rs189897 and rs2212020 polymorphisms and its haplotype with the occurrence of cerebral infarction ( CI ) . - pubmed
METHODS : In the venous blood samples from 250 patients with cerebral infarction and 250 control samples , the genotypes of rs189897 and rs2212020 of ITGA9 gene were identified by PCR - sequencing . - pubmed
CONCLUSION : rs189897 and rs2212020 in ITGA9 gene are closely related to CI , and its A - C haplotype is the protective factor against CI . - pubmed
Serum levels of vascular epithelial growth factor ( VEGF ) , which is considered to be a causative factor of endothelial lesions in POEMS syndrome , were not elevated throughout the course of this case . - pubmed
Immunoglobulin M nephropathy in a patient with systemic lupus . - pubmed
Immunoglobulin M ( IgM ) nephropathy is an uncommon glomerular disease characterized by IgM deposits in the mesangium . - pubmed
Renal biopsy revealed IgM nephropathy , with no clear evidence of lupus nephritis . - pubmed
Presently , recombinant tissue plasminogen activator is the only approved drug for the management of acute ischemic stroke . - pubmed
Twenty four hours after MCAo , motor performance was assessed and the animals were euthanized for estimation of brain malondialdehyde , glutathione , myeloperoxidase and nitric oxide levels . - pubmed
T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice . - pubmed
Carcinoembryonic antigen ( CEA ) is highly expressed on the surface of pancreatic adenocarcinoma cells ; we investigated the effects of cytolytic T cells that recognize CEA in a mouse model of pancreatic carcinoma . - pubmed
METHODS : Immune - competent mice that expressed the CEA transgene ( CEAtg ) in the intestinal and pulmonary tracts were given intrapancreatic injections of Panc02 CEA(+ ) cells ( express CEA and click beetle luciferase ) and tumors were grown for 10 days . - pubmed
RESULTS : Injection of the anti - CEA CAR T cells reduced the size of pancreatic tumors to below the limit of detection in all mice and produced long - term tumor eradication in 67 % of mice . - pubmed
T cells also eradicated CEA(+ ) fibrosarcoma cells injected 45 days later . - pubmed
CONCLUSIONS : Injection of T cells that target CEA can eradicate tumors grown from CEA(+ ) pancreatic carcinoma cells in the pancreas of CEAtg mice without autoimmune effects . - pubmed
Collectively , our data strongly suggest a critical role for CD4(+ ) T help in multiple phases of AdV - stimulated CTL responses , and could partially explain certain failures in AdV - based immunization trials targeting malignant tumors and chronic diseases that are often associated with compromised CD4(+ ) T cell population and function . - pubmed
Monocytosis at diagnosis was associated with lymphocyte count , deletions of chromosomes 17p and 11q , the extent of IgVH somatic hypermutation and Binet stage . - pubmed
RESULTS : Four - month oral resveratrol administration to diabetic rats ( 5 mg / kg / day ) alleviated the reduction of cardiac antioxidant enzymes activities ( 3.88 + - 0.48 vs. 1.49 + - 0.43 U , p & lt ; 0.05 for superoxide dismutase , and 2.72 + - 0.26 vs. 1.18 + - 0.19 nmol / min / mL , p & lt ; 0.05 for catalase ) and the enhancement of cardiac oxidative markers ( 5.01 + - 0.37 vs. 7.23 + - 0.51 ng , p & lt ; 0.05 for 8 - isoprostane , 6.03 + - 0.87 vs. 8.49 + - 0.52 mumol , p & lt ; 0.05 for nitrite / nitrate , and 0.44 + - 0.03 vs. 0.59 + - 0.04 , p & lt ; 0.05 for oxidized / reduced glutathione ratio ) , nuclear factor kappa B activity ( 0.37 + - 0.09 vs. 0.60 + - 0.11 , p & lt ; 0.05 ) and apoptosis rate ( 0.98 + - 0.28 vs.1.63 + - 0.16 , p & lt ; 0.05 ) . - pubmed
The use of incretin - based therapies , such as the dipeptidyl peptidase-4 ( DPP-4 ) inhibitors and glucagon - like peptide-1 ( GLP-1 ) analogs , is growing in patients with T2DM , due to their efficacy and tolerability profiles . - pubmed
As renal safety is a key factor when choosing treatment options to manage patients with T2DM , drugs that are suitable for use in patients with varying degrees of renal impairment without a requirement for dose adjustment , such as the DPP-4 inhibitor linagliptin , are of particular use . - pubmed
HLA - DPB1 * 04:01 allele is associated with non - obstructive azoospermia in Japanese patients . - pubmed
Previous studies reported that specific alleles and single nucleotide polymorphisms ( SNPs ) in the human leukocyte antigen ( HLA ) region were associated with NOA in East Asians . - pubmed
We attempt to expand upon previous findings by genotyping more HLA genes and to replicate SNP associations by focusing on Japanese NOA patients . - pubmed
HLA typing of six genes ( HLA - A , -B , -C , -DRB1 , -DQB1 , and -DPB1 ) was done on 355 NOA patients using SSO - Luminex assay while genotyping of two previously reported SNPs ( rs498422 and rs3129878 ) was done on 443 patients and 544 fertile males using TaqMan assay . - pubmed
We found that HLA - DPB1 * 04:01 [ corrected p value , P(c ) 7.13 x 10(-6 ) ; odds ratio ( OR ) 2.52 ] , DRB1 * 13:02 ( P(c ) 4.93 x 10(-4 ) , OR 1.97 ) , DQB1 * 06:04 ( P(c ) 8.94 x 10(-4 ) , OR 1.91 ) and rs3129878 ( p value 3.98 x 10(-4 ) ; OR 1.32 ) showed significant association with NOA , however , these loci are in linkage disequilibrium with each other . - pubmed
The conditional logistic regression tests showed that DPB1 * 04:01 is independently associated with NOA , confirming the involvement of the HLA region in the etiology of NOA in Japanese patients . - pubmed
Comment on " changes and regulation of the C5a receptor on neutrophils during septic shock in humans " . - pubmed
In mid-2011 , the addition of direct - acting antiviral agents ( DAAs)-the protease inhibitors boceprevir ( Victrelis , Merck ) and telaprevir ( Incivek , Vertex)-to pegylated interferon alpha-2a / b and ribavirin revolutionized the treatment of HCV infection by increasing cure rates across all fibrosis scores in patients with genotype 1 HCV infection . - pubmed
Findings from patients with dry eye have implicated defects in innate immunity ( Toll - like receptors , S100A and resident antigen - presenting cells ) , cytokines , chemokines and T helper ( TH)-cell subsets ( including TH1 and TH17 ) in disease pathogenesis . - pubmed
Tissue damage is treated by inhibiting matrix metalloproteinases . - pubmed
Breast cancer genes : looking for BRACA 's lost brother . - pubmed
AMP - activated protein kinase ( AMPK ) is a critical regulator of cellular metabolism and plays an important role in diabetes , cancer , and vascular disease . - pubmed
In the heart , AMPK activation is an essential component of the adaptive response to cardiomyocyte stress that occurs during myocardial ischemia . - pubmed
During ischemia - reperfusion , AMPK activation modulates glucose and fatty acid metabolism , mitochondrial function , endoplasmic reticulum ( ER ) stress , autophagy , and apoptosis . - pubmed
Pharmacological activation of AMPK prevents myocardial necrosis and contractile dysfunction during ischemia - reperfusion and potentially represents a cardioprotective strategy for the treatment of myocardial infarction . - pubmed
This review discusses novel mechanisms of AMPK activation in the ischemic heart , the role of endogenous AMPK activation during ischemia , and the potential therapeutic applications for AMPK - directed therapy . - pubmed
Trametinib radiosensitises RAS- and BRAF - mutated melanoma by perturbing cell cycle and inducing senescence . - pubmed
By immunohistochemistry the expression of Fas receptor and Fas - L was higher in the skin of lupus patients compared with controls . - pubmed
We also noted differences in Fas - L , -Fas , and -Bax proteins expression intensity in discoid lupus erythematosus patients in the epidermis , and hair follicles . - pubmed
CONCLUSIONS : Fas and Fas - L are expressed similarly in LP and DLE . - pubmed
Lumbar Disc Degeneration is Facilitated by MiR-100 - Mediated FGFR3 Suppression . - pubmed
BACKGROUND / AIMS : The pathogenesis of lumbar disc degeneration ( LDD ) involved activation of matrix metalloproteinase 13 ( MMP13 ) by differential expression of fibroblast growth factor receptor 1 ( FGFR1 ) and FGFR3 . - pubmed
METHODS : We examined the FGFR1 and FGFR3 levels and microRNAs ( miRNAs ) levels in the resected LDD discs , compared to the traumatized , non - LDD discs . - pubmed
RESULTS : The levels of FGFR1 and miR-100 were significantly higher , while the levels of FGFR3 were significantly lower , in LDD discs , compared to the control non - LDD discs . - pubmed
CONCLUSION : miR-100 may activate MMP13 through 3'UTR - suppressoin of FGFR3 mRNA to facilitate development of LDD . - pubmed
Possible Role of HER-2 in the Progression of Prostate Cancer from Primary Tumor to Androgen Independence . - pubmed
BACKGROUND : The expression of HER-2 in prostate cancer has been linked to disease progression . - pubmed
We analysed the presence of HER-2 expression in primary tumors in men undergoing radical prostatectomy , its association with clinical and pathological findings , and its expression in secondary circulating prostate cells ( CPCs ) during follow up , as well as links with biochemical failure and the effects of androgen blockade . - pubmed
HER-2 expression in the primary tumor was assessed using the HercepTest , CPCs were identified from blood samples using standard immunocytochemistry with anti - PSA and positive samples with the HercepTest to determine HER-2 expression . - pubmed
HER-2 was expressed in 20.8 % of primary tumors ; it was associated with vascular infiltration and older age , but not with other clinical pathological findings . - pubmed
Some 40.3 % of men had secondary CPCs detected , of which 38 % expressed HER-2 . - pubmed
After androgen blockade , men with HER-2 ( + ) positive secondary CPCs had a higher frequency of disease progression to castrate resistant disease . - pubmed
CONCLUSIONS : HER-2 plays a dual role in the progression of prostate cancer ; firstly it may increase the potential of tumor cells to disseminate from the primary tumor via the blood by increasing vascular infiltration . - pubmed
NOD2 Loss - of - Function Mutations and Risks of Necrotizing Enterocolitis or Focal Intestinal Perforation in Very Low - birth - weight Infants . - pubmed
BACKGROUND : NOD2 loss - of - function mutations , that is , R702W [ rs2066844 ] , G908R [ rs2066845 ] , and Leu1007fsinsC [ rs5743293 ] , have been linked to inflammatory bowel diseases . - pubmed
We assessed the effect of the NOD2 gene variants on the risk for major morbidities of the gastrointestinal tract , that is , NEC / FIP requiring surgery in multivariable logistic regression analyses . - pubmed
RESULTS : In the whole cohort of VLBW infants , carriers of & gt;= 2 NOD2 variant alleles had an increased risk for NEC requiring surgery ( odds ratio [ OR ] , 3.57 ; 95 % confidence interval [ CI ] , 1.27 - 10.04 ; P = 0.03 ) and NEC or FIP requiring surgery ( OR , 3.81 ; 95 % CI , 1.70 - 8.51 ; P = 0.004 ) as compared with wild - type genotypes . - pubmed
In a multivariable logistic regression analysis including gestational age , birth weight , gender , multiple birth , and inborn delivery , the association between & gt;= 2 NOD2 variant alleles and NEC surgery ( OR , 4.14 ; 95 % CI , 1.41 - 12.12 ; P = 0.009 ) , FIP surgery ( OR , 3.50 ; 95 % CI , 1.02 - 12.04 ; P = 0.047 ) , and NEC or FIP surgery ( OR , 4.10 ; 95 % CI , 1.74 - 9.73 ; P = 0.001 ) proved to be independent . - pubmed
Although probiotics had a protective effect on NEC and NEC or FIP requiring surgery , the NOD2 variants had no significant impact in this subgroup . - pubmed
CONCLUSIONS : VLBW infants carrying & gt;= 2 NOD2 genetic risk factors of inflammatory bowel disease in adults have an increased risk for severe gastrointestinal complications , such as NEC requiring surgery . - pubmed
BACKGROUND : The phosphodiesterase-5 inhibitor sildenafil has been shown to attenuate delayed cerebral ischemia ( DCI ) and improve neurologic function in experimental subarachnoid hemorrhage ( SAH ) . - pubmed
RESULTS : Depending on the modelling approach applied , albumin , body surface area , neutrophil , baseline tumour size and tumour shrinkage measures were identified as potential prognostic factors . - pubmed
PNMA2 , a member of the Paraneoplastic Ma Family ( PNMA ) , was identified through expression cloning by using anti - sera from patients with paraneoplastic disorder . - pubmed
Tissue expression studies showed that PNMA2 was predominantly expressed in normal human brain ; however , the protein was shown to exhibit abnormal expression profile as it was found to be expressed in a number of tumour tissues obtained from paraneopalstic patients . - pubmed
Cost - Effectiveness Analysis of Ugt1a1 Genotyping Before Colorectal Cancer Treatment with Irinotecan . - pubmed
Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease . - pubmed
In SEA , clinical studies are urgently needed to monitor ACT efficacy where K13 mutations are prevalent , test whether new combinations of currently available drugs cure ACT failures , and advance new antimalarial compounds through preclinical pipelines and into clinical trials . - pubmed
TNF - like weak inducer of apoptosis ( TWEAK ) receptor Fn14 is expressed by podocytes and Fn14 deficiency protects from experimental proteinuric kidney disease . - pubmed
Increased kidney Fn14 and CCL21 expression was also observed in rat proteinuric kidney disease induced by puromycin , and was localized to podocytes . - pubmed
The non - canonical NFkappaB pathway should be explored as a potential therapeutic target in proteinuric kidney disease . - pubmed
Nuclear and extranuclear - initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer . - pubmed
There are various ERalpha targeting agents that have been used for treatment of ER ( + ) breast tumors . - pubmed
The impact of direct nuclear activity of ER is very well characterized in ER ( + ) breast cancers and development and progression of endocrine resistance . - pubmed
In this mini - review , we will discuss the role of nuclear and extra - nuclear ER signaling and how they relate to therapy resistance in breast cancer . - pubmed
Safety Studies in Tumor and Non - Tumor - Bearing Mice in Support of Clinical Trials Using Oncolytic VSV - IFNbeta - NIS . - pubmed
Oncolytic VSV - IFNbeta - NIS is selectively destructive to tumors . - pubmed
Clinical translation of VSV - IFNbeta - NIS is underway in companion dogs with cancer and in human patients with relapsed hematological malignancies and endometrial cancer . - pubmed
Asymptomatic CMV Replication During Early Human Immunodeficiency Virus ( HIV ) Infection Is Associated With Lower CD4 / CD8 Ratio During HIV Treatment . - pubmed
BACKGROUND : A low CD4 / CD8 ratio in human immunodeficiency virus ( HIV )- infected individuals is associated with inflammation and higher risk of non - AIDS morbidity and mortality . - pubmed
In this study , we investigated the effect of subclinical cytomegalovirus ( CMV ) and Epstein - Barr virus ( EBV ) replication on CD4 + and CD8 + T - cell dynamics when antiretroviral therapy ( ART ) is started during early infection . - pubmed
CONCLUSIONS : Subclinical CMV replication in blood cells during early HIV infection and younger age were associated with lower CD4 / CD8 ratios during suppressive ART . - pubmed
NSP4 antibody levels in rotavirus gastroenteritis patients with seizures . - pubmed
BACKGROUND : Rotavirus nonstructural protein 4 ( NSP4 ) has been suggested as a pathogen of rotavirus - associated seizures . - pubmed
We investigated pre - existing serum antibodies against NSP4 and VP6 ( the most highly immunogenic rotavirus protein ) in patients with rotavirus gastroenteritis and its correlation with the occurrence of seizures . - pubmed
METHODS : With an enzyme - linked immunosorbent assay , IgG and IgA titers against NSP4 ( genotype [ A ] and [ B ] ) and VP6 were measured in acute - phase sera of 202 children aged 0.5 - 6.0 years with rotavirus gastroenteritis . - pubmed
Age , sex , hospital stay , presence of fever , white blood cell counts , C - reactive protein , vaccine status , IgG / IgA titers for VP6 , and IgA titers for both NSP4s did not differ between the groups . - pubmed
The seizure group showed a lower level of IgG against NSP4 [ A ] ( 184.5 vs. 163.0 U / mL ; P = 0.03 ) and NSP4 [ B ] ( 269.0 vs. 196.0 U / mL ; P = 0.02 ) . - pubmed
Even after adjusting these factors , anti - NSP4 [ A ] IgG ( OR 2.56 per 100 U / mL increment ; 95 % CI , 1.20 - 5.26 , P = 0.01 ) and anti - NSP4 [ B ] IgG ( OR 1.51 per 100 U / mL - increment ; 95 % CI , 1.04 - 2.22 , P = 0.03 ) were independently associated with protection against seizures . - pubmed
CONCLUSIONS : Serum anti - NSP4 IgG might protect rotavirus - associated seizures . - pubmed
Using tuberous sclerosis complex to understand the impact of MTORC1 signaling on mitochondrial dynamics and mitophagy in neurons . - pubmed
Constitutive activation of the MTOR pathway is a key feature of defects in the tuberous sclerosis complex and other genetic neurodevelopmental diseases , collectively referred to as MTORopathies . - pubmed
Erratum to : Usefulness of combining admission brain natriuretic peptide ( BNP ) plus hospital discharge bioelectrical impedance vector analysis ( BIVA ) in predicting 90 days cardiovascular mortality in patients with acute heart failure . - pubmed
The ENTPD1 promoter polymorphism -860 A & gt ; G ( rs3814159 ) is associated with increased gene transcription , protein expression , CD39 / NTPDase1 enzymatic activity , and thromboembolism risk . - pubmed
Ectonucleoside triphosphate diphosphohydrolase 1 ( NTPDase1 ) degrades the purines ATP and ADP that are key regulators of inflammation and clotting . - pubmed
We sequenced the ENTPD1 gene ( encoding NTPDase1 ) in 216 subjects then assessed genotypes in 2 cohorts comprising 2213 humans to identify ENTPD1 polymorphisms associated with venous thromboembolism ( VTE ) . - pubmed
Thus , the G allele of rs3176891 marks a haplotype associated with increased clotting and platelet aggregation attributable to a promoter variant associated with increased transcription , expression , and activity of NTPDase1 . - pubmed
The ENTPD1 promoter polymorphism -860 A & gt ; G ( rs3814159 ) is associated with increased gene transcription , protein expression , CD39 / NTPDase1 enzymatic activity , and thromboembolism risk . - pubmed
Bioinformatic analysis suggested that statin - induced miRNAs functions were primarily enriched in angiogenesis , integrin and platelet derived growth factor signaling pathways in UA patients . - pubmed
Replication of rs300774 , a genetic biomarker near ACP1 , associated with suicide attempts in patients with schizophrenia : Relation to brain cholesterol biosynthesis . - pubmed
CONCLUSIONS : Our results indicate that small - scale multiregional sampling and subsequent screening of low VAF somatic mutations might be a cost - effective strategy for identifying the majority of trunk mutations in gastric carcinoma . - pubmed
Glycosaminoglycan ( GAG ) enrichment is a dominant hallmark of early CAVD , but culture of valvular interstitial cells ( VICs ) in biomaterial environments containing pathological amounts of hyaluronic acid ( HA ) or chondroitin sulfate ( CS ) did not directly increase indicators of disease progression such as VIC activation or inflammatory cytokine production . - pubmed
However , HA - enriched matrices increased production of vascular endothelial growth factor ( VEGF ) , while matrices displaying pathological levels of CS were effective at retaining lipoproteins , whose deposition is also found in early CAVD . - pubmed
Nucleostemin regulates proliferation and migration of gastric cancer and correlates with its malignancy [ Retraction ] . - pubmed
Response to stretching was remarkably reduced in a rat model of LV hypertrophy , which also failed to increase titin phosphorylation . - pubmed
Comparison of HbA1c and glycated albumin as a control marker for newborn complications in diabetic women in a multicentre study in Japan ( Japan glycated albumin study group : study 2 ) . - pubmed
Background To clarify the relationship between glycated haemoglobin and glycated albumin concentrations during pregnancy with neonatal outcomes , a multicentre study was conducted by the Japanese Society of Diabetes and Pregnancy . - pubmed
On the other hand , the frequency of neonatal complications showed higher tendency of neonatal complications in the incidence of polycythaemia ( P = 0.094 ) and heavy - for - date ( P = 0.071 ) in the glycated albumin & gt;=15.8 % group compared with the glycated albumin & lt;15.8 group . - pubmed
Conclusions For the treatment of pregnant women with diabetes , glycated albumin would be a better marker than glycated haemoglobin . - pubmed
However , glycated albumin is also affected by obesity and albumin , and it is desirable to make a comprehensive judgment with glycated haemoglobin , random plasma glucose and other glycaemic index . - pubmed
Icariside II ameliorates ibotenic acid - induced cognitive impairment and apoptotic response via modulation of MAPK pathway in rats . - pubmed
ICS II administrated at doses of 8 and 16 mg / kg not only rescued behavioral performance , but also protected hippocampal neurons against neurotoxicity via suppressing the elevation of Bax / Bcl-2 ratio and the activation of caspase-3 . - pubmed
CONCLUSION : These results suggest that ICS II attenuates IBO - induced cognitive deficits , possibly via the regulation of calbindin expression and the inhibition of apoptotic response . - pubmed
In addition , the MAPK signaling pathway is implicated in the potential mechanisms of ICS II against IBO - induced excitotoxicity , indicating that ICS II is a promising compound for treatment of excitotoxicity - related diseases , including AD . - pubmed
Exome data analysis revealed significantly mutated genes previously linked to SBA ( TP53 , KRAS , APC , SMAD4 , and BRAF ) , recently reported potential driver genes ( SOX9 , ATM , and ARID2 ) , as well as novel candidate driver genes , such as ACVR2A , ACVR1B , BRCA2 , and SMARCA4 . - pubmed
Prior to infection five animals showed positive IFN - gamma responses to avian PPD ( PPD - A ) and four were positive in Map PCR ( IS900 ) on faeces . - pubmed
bovis infected animals reacted as early as day 14 with sustained higher PPD - B than PPD - A specific IFN - gamma responses , whereas the fourth animal ( with the strongest PPD - A response prior to infection ) showed sustained higher PPD - B specific IFN - gamma levels only a day 56 after infection . - pubmed
Later during infection , positive responses were found to ESAT-6 peptides in three infected bulls and to CFP-10 peptides in all four infected bulls . - pubmed
These data reveal a novel contribution of autoreactive CD8 T cells to autoimmune disease , in part , through CD4 follicular - like differentiation and functionality . - pubmed
Earlier studies have shown that treatment of keratinocytes and mouse skin with the green tea polyphenol ( -)- epigallocatechin-3 - gallate ( EGCG ) mitigated inflammation and increased the expression of caspase-14 while promoting epidermal differentiation and cornification . - pubmed
Topically applied nanoEGCG elicited a significant ( p<0.01 ) amelioration of psoriasiform pathological markers in IMQ - induced mouse skin lesions , including reductions in ear and skin thickness , erythema and scales , proliferation ( Ki-67 ) , infiltratory immune cells ( mast cells , neutrophils , macrophages , and CD4 + T cells ) , and angiogenesis ( CD31 ) . - pubmed
Importantly , a significant modulation of several psoriasis - related inflammatory cytokines and chemokines was observed compared to the high dose of free EGCG ( p<0.05 ) . - pubmed
Chaihu - Shugan - San Decoction Modulates Intestinal Microbe Dysbiosis and Alleviates Chronic Metabolic Inflammation in NAFLD Rats via the NLRP3 Inflammasome Pathway . - pubmed
We evaluate the effects of the Chaihu - Shugan - San decoction on intestinal microbe dysbiosis and chronic metabolic inflammation via the NLRP3 pathway in NAFLD rats that were fed a high - fat diet . - pubmed
In summary , the Chaihu - Shugan - San decoction modulated intestinal microbe dysbiosis , reduced fat accumulation , and alleviated inflammatory factor expression , which are all processes related to the NLRP3 inflammasome pathway in NAFLD rats . - pubmed
Nuclear factor - erythroid 2 - related factor-2 ( Nrf2 ) is a key transcription factor limits the tumor progression . - pubmed
Meanwhile , hyper activation of NF - kappaB transcription factors was witnessed in the tumor cells . - pubmed
Antagonistic activity of BITC , PEITC and SFN against cancer was related with the direct / indirect interaction with Nrf2 and NF - kappaB protein . - pubmed
We have also discussed the molecular interaction(s ) of the antagonistic effect of BITC , PEITC and SFN with Nrf2 and NF - kappaB to prevent cancer . - pubmed
Characteristics and outcomes of therapy - related myeloid neoplasms after peptide receptor radionuclide / chemoradionuclide therapy ( PRRT / PRCRT ) for metastatic neuroendocrine neoplasia : a single - institution series . - pubmed
PURPOSE : Peptide receptor radionuclide / chemoradionuclide therapy ( PRRT / PRCRT ) is an effective therapy for metastatic neuroendocrine neoplasia ( NEN ) , but therapy - related myeloid neoplasms ( t - MN ) remain of concern . - pubmed
AQP8 and AQP9 expression in patients with polycystic ovary syndrome and its association with in vitro fertilization - embryo transfer outcomes . - pubmed
The aim of the present study was to investigate aquaporin ( AQP ) 8 and AQP9 expression in patients with polycystic ovary syndrome ( PCOS ) and its association with in vitro fertilization - embryo transfer ( IVF - ET ) outcomes . - pubmed
A total of 45 patients with PCOS undergoing IVF - ET ( test group ) and 50 patients with oviduct obstruction or ovarian cyst ( control group ) were assessed for the mRNA expression of AQP8 and AQP9 in ovarian tissues by reverse transcription - quantitative ( RT - q)PCR . - pubmed
In conclusion , AQP8 and AQP9 are differentially expressed in ovarian tissues of patients with PCOS vs. normal control subjects . - pubmed
The expression of AQP8 is closely associated with the occurrence and development of oocytes , whereas the expression of AQP9 is associated with the success rate of pregnancy in patients with PCOS . - pubmed
Sinomenine retards LPS - elicited inflammation via down - regulating CCAT1 in HaCaT cells . - pubmed
Sinomenine pre - administration maintained cell viability , blocked apoptosis and relieved inflammation with the decrease in cleaved caspase-3 /- 9 and inflammatory factors . - pubmed
LINC00342 regulates cell proliferation , apoptosis , migration and invasion in colon adenocarcinoma via miR-545 - 5p / MDM2 axis . - pubmed
METHODS : The LINC00342 expressions in COAD tissues were detected via qRT - PCR and in situ hybridization analysis . - pubmed
RESULTS : LINC00342 was over - expressed in COAD tissues and LINC00342 overexpression was related to the poor prognosis of COAD patients . - pubmed
In COAD tissues and cell lines , LINC00342 expression was positively correlated to MDM2 expression , while it was negatively correlated to miR-545 - 5p expression . - pubmed
LINC00342 knockdown suppressed COAD tumor growth in vivo . - pubmed
Microbiota - Derived Metabolites Suppress Arthritis by Amplifying Aryl - Hydrocarbon Receptor Activation in Regulatory B Cells . - pubmed
Butyrate supplementation suppresses arthritis in a Breg - dependent manner by increasing the level of the serotonin - derived metabolite 5 - Hydroxyindole-3 - acetic acid ( 5 - HIAA ) , which activates the aryl - hydrocarbon receptor ( AhR ) , a newly discovered transcriptional marker for Breg function . - pubmed
It has been reported that angiotensin II ( Ang - II ) damages the function of EPCs in atherosclerotic plaque through induction of oxidative stress . - pubmed
Our study results indicated that Sesn2 facilitated the viability of EPCs After treatment with Ang - II , as well as provided a potential therapeutic target to alleviate the progression of atherosclerosis . - pubmed
Marein ameliorates Ang II / hypoxia - induced abnormal glucolipid metabolism by modulating the HIF-1alpha / PPARalpha / gamma pathway in H9c2 cells . - pubmed
Treating angiotensin II / hypoxia - stimulated H9c2 cells with marein led to decreasing cell surface area , intracellular total protein , atrial natriuretic peptide , and free fatty acids levels , but increasing glucose level . - pubmed
The effect of nutmeg essential oil constituents on Novikoff hepatoma cell viability and communication through Cx43 gap junctions . - pubmed
Disappearance of a highly unusual clone , 46,XY , del(7)(p12),t(9;22)(q34;q11 ) in chronic myeloid leukemia after treatment with recombinant interferon and cytosine arabinoside . - pubmed
Toxicity was limited to asymptomatic SGOT elevations in 3 patients and nausea and vomiting in 4 patients that required cessation of therapy in 2 . - pubmed
The purpose of the present studies was to compare the pharmacodynamic profile of the new ACE inhibitor cilazapril with the beta - adrenoceptor antagonist propranolol in healthy subjects and in hypertensive patients . - pubmed
Phospholipase A2 , leukotriene C4 and prostaglandin E2 levels in aqueous humour of guinea pigs with experimental S - antigen induced autoimmune uveitis . - pubmed
Purified S - antigen was used to induce experimental autoimmune uveitis in 42 guinea pigs . - pubmed
In aqueous humour the increase in phospholipase - A2 and proteins as well as myeloperoxidase measured from iris - ciliary blocks correlated well with the severity of uveitis evaluated by clinical grading . - pubmed
Of these biochemical parameters , only gamma glutamyl transpeptidase was significantly elevated in test animals with experimental autoimmune uveitis . - pubmed
Effects of insulin perfusion and altered glucose concentrations on heart function in 3 - day and 6 - week diabetic rats . - pubmed
Diabetes is known to result in depression of myocardial function , whereas hearts from insulin - treated diabetic rats exhibit functional characteristics similar to controls . - pubmed
In the present study , we have studied the effect of insulin perfusion on cardiac performance of 3 - day and 6 - week streptozotocin ( STZ ) diabetic rats . - pubmed
These results suggest that diabetes results in a loss of myocardial sensitivity to insulin which seems to occur as early as 3 days after induction of diabetes with STZ . - pubmed
The study also demonstrates that the beneficial effects of in vivo insulin treatment on myocardial alterations induced by diabetes are not due to its direct myocardial effects . - pubmed
The application of radioimmunoassay of insulin , C - peptide , gastrin , glucagon , vasoactive intestinal polypeptides ( VIP ) , somatostatin , human pancreatic polypeptides ( hPP ) , substance P and neurotensin to detect endocrine tumors of the pancreas and other organ systems is undoubtedly important in the clinical management of patients suspected of having tumors that secrete these hormones . - pubmed
Response to fibrinolytic activity and factor VIII - related antigen to stimulation with desmopressin in hyperlipoproteinemia . - pubmed
Factor VIII was higher than normal in most patients with hyperlipoproteinemia ; the level increased after stimulation with DDAVP in every patient . - pubmed
In addition , the immune dysfunctions that characterize some human diseases , such as cancer , depend not only on the immune system per se , but also at least in part , on altered secretion of immunomodulating neurohormones , including MLT and opioid peptides . - pubmed
The study was performed in 90 patients with advanced solid neoplasms , who received IL-2 at a dose of 3 million IU / day subcutaneously for 6 days a week for 4 weeks plus MLT at a daily dose of 40 mg . - pubmed
The results were compared to those in 40 cancer patients treated with IL-2 alone . - pubmed
GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose - stimulated insulin release . - pubmed
The rat insulinoma cell line RIN 1046 - 38 loses glucose - stimulated insulin secretion as a function of time in culture . - pubmed
None of the patients experienced severe leukopenia at the time of diagnosis , but the mean lymphocyte count decreased to 495 / mm3 ( range 100 to 830 / mm3 ) and 2 patients had inverted CD4 / CD8 T - cell ratios . - pubmed
Endometrial expression of mRNA encoding epidermal growth factor receptor in normal and leiomyomatous uteri throughout the menstrual cycle . - pubmed
CONCLUSION : This data suggest that endometrial EGFR mRNA expression varies in association with the histologic changes of the normal menstrual cycle , and may be associated with the presence of leiomyomata uteri . - pubmed
Hypertriglyceridemic effect of fructose is mainly due to an increase in hepatic production of VLDL . - pubmed
Interferon and thymic hormones in the therapy of human myocarditis and idiopathic dilated cardiomyopathy . - pubmed
The aim of this study was to evaluate the efficacy of interferon - alpha ( IFN ) and thymomodulin in the treatment of idiopathic myocarditis and IDC . - pubmed
Our results suggest that treatment of myocarditis and/or IDC with IFN or thymomodulin induces an earlier and significantly superior clinical improvement than conventional therapy alone . - pubmed
Immunolocalisation of the kinin moiety and bradykinin ( B2 ) receptors on synovial fluid neutrophils in rheumatoid arthritis . - pubmed
Generation of Alzheimer beta - amyloid protein in the trans - Golgi network in the apparent absence of vesicle formation . - pubmed
beta - amyloid protein ( A beta ) formation was reconstituted in permeabilized neuroblastoma cells expressing human Alzheimer beta - amyloid precursor protein ( beta APP ) harboring the Swedish double mutation associated with familial early - onset Alzheimer disease . - pubmed
Does insulin resistance unite the separate components of the insulin resistance syndrome ? - pubmed
The observation that M loaded on both factors suggests that a resistance to insulin action may provide the mechanism uniting the features of the insulin resistance syndrome . - pubmed
Transforming growth factor - beta ( TGF - beta ) has been shown to stimulate extracellular matrix formation and inhibit proteolytic matrix degradation in periodontal wound healing . - pubmed
Short - chain fatty acids inhibit intestinal trefoil factor gene expression in colon cancer cells . - pubmed
Intestinal trefoil factor ( ITF ) gene expression was detected in five colon cancer cell lines . - pubmed
We conclude that butyrate inhibits ITF expression in colon cancer cells and that this effect may be mediated transcriptionally and independently of its effects on differentiation . - pubmed
Bispecific antibodies capable of simultaneously binding a tumor surface antigen and the T - cell receptor / CD3 complex are capable of inducing polyclonal immune effector cells to destroy targeted tumor cells . - pubmed
The bispecific ligand - antibody conjugate described in this study is a chemical conjugate between an anti - CD3 monoclonal antibody ( MAb ) and folic acid , the ligand for a high - affinity surface receptor expressed on the surface of choroid plexus tumors . - pubmed
SV11 mice transgenic for SV40 large T antigen and its promoter develop solid choroid plexus tumors in the brain . - pubmed
Sustained high - level expression of full - length human factor VIII and restoration of clotting activity in hemophilic mice using a minimal adenovirus vector . - pubmed
The successful prophylactic treatment of hemophilia A by frequent infusions of plasma concentrates or recombinant factor VIII ( hFVIII ) indicates that gene therapy may be a potential alternative for the treatment of the disease . - pubmed
The functionality of the protein was confirmed by the restoration of blood coagulation capacity in MiniAdFVIII - treated hemophilic mice , as determined by tail clipping observations . - pubmed
METHODS : Maternal and fetal circulating angiogenin concentrations were compared at birth between 16 pregnancies with SGA ( 7 delivered vaginally and 9 delivered by elective cesarean section ) and 46 pregnancies with AGA ( 27 delivered vaginally and 19 delivered by cesarean section ) . - pubmed
However , maternal serum angiogenin levels were significantly higher than those in fetal serum within both SGA and AGA infant pregnancies . - pubmed
CONCLUSION : These results suggest that there is no difference in angiogenin synthesis between SGA and AGA pregnancies . - pubmed
Scar , a member of the WASp protein family , was discovered in Dictyostelium discoideum during a genetic screen for second - site mutations that suppressed a developmental defect . - pubmed
Possible involvement of endothelin-1 and nitric oxide in the pathogenesis of proliferative diabetic retinopathy . - pubmed
BACKGROUND : Overproduction of endothelin-1 ( ET-1 ) and nitric oxide ( NO ) in the retina is demonstrated in experimental diabetic animals . - pubmed
To clarify the possible involvement of ET-1 and NO in the pathogenesis of diabetic retinopathy , the authors examined the vitreous levels of these principal endothelium - derived vasoactive substances in patients with proliferative diabetic retinopathy ( PDR ) . - pubmed
RESULTS : Endothelin-1 levels ( mean + /- SE ) were 21.5 + /- 1.7 pg / mL in the vitreous of patients with PDR and 16.7 + /- 0.7 pg / mL in the vitreous of patients with macular hole . - pubmed
CONCLUSION : These results indicate that ET-1 and NO may be related in the pathogenesis of PDR . - pubmed
Proinsulin C - peptide has been reported to have some biological activities and to be possibly involved in the development of diabetic microangiopathy . - pubmed
Attenuation of hemolysate - induced cerebrovascular endothelial cell injury and of production of endothelin-1 and big endothelin-1 by an endothelin - converting enzyme inhibitor . - pubmed
BACKGROUND : Endothelin-1 ( ET-1 ) is a potent and long - acting vasoconstrictive peptide that has been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage ( SAH ) . - pubmed
ET-1 has been shown to be present in the cerebrospinal fluid of patients after SAH , and substances produced during hemolysis of subarachnoid blood clots are believed to be responsible for stimulating the production of ET-1 . - pubmed
Activation of the c - Jun N terminal kinase pathway in an animal model of Parkinson ' s disease . - pubmed
We studied the pattern of activation of the c - Jun N terminal kinase ( JNK ) signal transduction pathway during the course of a subacute MPTP mouse model of Parkinson ' s disease . - pubmed
[ Study of reactions for detection of the rheumatoid factor in the course of syphilis ] . - pubmed
Identification and clinical relevance of receptor activator of nuclear factor kappaB ligand expression of myeloma cells . - pubmed
Microgranular and t(11;17)/PLZF - RARalpha variants of acute promyelocytic leukemia also present the flow cytometric pattern of CD13 , CD34 , and CD15 expression characteristic of PML - RARalpha gene rearrangement . - pubmed
Homogeneous expression of CD33 was observed in 76 % of the classical APL cases and in 100 % of the microgranular cases . - pubmed
Additionally , we have studied two cases of PLZF - RARalpha APL that also displayed the same immunophenotype described for classical APL . - pubmed
Thus , the immunophenotypic profile highly characteristic of the PML - RARalpha gene rearrangement was also observed in microgranular and PLZF - RARalpha variants of APL . - pubmed
Polyploid formation via chromosome duplication induced by CTP : phosphocholine cytidylyltransferase deficiency and Bcl-2 overexpression : identification of two novel endogenous factors . - pubmed
Alterations in the alpha2 isoform of Na , K - ATPase associated with familial hemiplegic migraine type 2 . - pubmed
A number of missense mutations in the Na , K - ATPase alpha2 catalytic subunit have been identified in familial hemiplegic migraine with aura . - pubmed
Here , we investigate the proatherogenic role of NKT cells in an adoptive transfer model of atherosclerosis , using as recipients immune - deficient , atherosclerosis - susceptible RAG1(-/-)LDLR(-/- ) mice . - pubmed
The total serum from hypercholesterolemic mice leads to a small but significant activation of Valpha14Jalpha18 T - cell receptor - expressing hybridoma line by dendritic cells that is CD1d - dependent . - pubmed
The patient carrying the last duplication presents sex reversal , Peters ' anomaly and renal cysts and the duplication is located 4Mb away from the HSD17B1 gene , coding a key enzyme of testosterone biosynthesis . - pubmed
Apixaban is an oral , direct Factor Xa inhibitor that is being developed by Bristol - Myers Squibb Co and Pfizer Inc. Apixaban is currently undergoing phase III clinical trials for cerebrovascular ischemia , deep vein thrombosis and lung embolism , and phase II clinical trials for coronary artery disease . - pubmed
Mutation in the HPGD gene encoding NAD + dependent 15 - hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing ( ICNC ) . - pubmed
CONCLUSIONS : The involvement of 15 - PGDH in the pathogenesis of ICNC may open up interesting perspectives into the function of this enzyme in nail morphogenesis / development . - pubmed
Some soluble markers , including soluble mesothelin and osteopontin , have been previously proposed for MPM diagnosis but none has been validated yet . - pubmed
Soluble mesothelin , assessed in blood and in pleural effusion , seems to be the most promising candidate . - pubmed
Despite sometimes a good sensitivity , other potential markers as osteopontin are of little interest for MPM diagnosis because of a low specificity . - pubmed
In conclusion , the present data do not justify the use of biology for MPM diagnosis in routine yet but rather suggest a need for a continuing evaluation of soluble mesothelin in clinical studies and the search for other potential tumor markers . - pubmed
[ Cerebral proteolysis of amiloid - b peptide : relevance of insulin - degrading enzyme in Alzheimer ' s disease ] . - pubmed
One of the distinctive features of AD is the excessive accumulation of amyloid - b ( Ab ) peptide in the brain . - pubmed
IDE expression and activity are significantly decreased in AD brains compared to age - matched controls . - pubmed
An autosomal recessive form of hereditary spastic paraplegia ( AR - HSP ) is primarily caused by mutations in the SPG7 gene , which codes for paraplegin , a subunit of the hetero - oligomeric m - AAA protease in mitochondria . - pubmed
In the current study , sequencing of the SPG7 gene in the genomic DNA of 25 unrelated HSP individuals / families led to the identification of two HSP patients with compound heterozygous mutations ( p. G349S / p. W583C and p. A510V / p. N739KfsX741 ) in the coding sequence of the SPG7 gene . - pubmed
We used a yeast complementation assay to evaluate the functional consequence of novel SPG7 sequence variants detected in the HSP patients . - pubmed
By acting as a scaffolding protein , Cav-1 plays crucial roles in the regulation of various physiologic and patho - physiologic processes including oncogenic transformation and tumorigenesis , and tumor invasion and metastasis . - pubmed
Genetic background affects susceptibility to ileocolitis in mice deficient in two intracellular glutathione peroxidases , GPx1 and GPx2 . - pubmed
The C57BL/6 ( B6 ) GPx1/2 double - knockout ( DKO ) mice have mild ileocolitis , and 129S1 / Sv ( 129 ) DKO mice have severe inflammation . - pubmed
We used diet to modulate ileocolitis ; a casein - based defined diet with AIN76A micronutrients ( AIN ) attenuates inflammation compared to conventional LabDiets . - pubmed
Replacement therapy with factor VIII ( FVIII ) concentrates has become the mainstay of treatment for hemophilia , but about 30 % of patients with a severe disease develop neutralizing antibodies against FVIII , which can lead to treatment resistance and an increased risk of bleeding . - pubmed
High - dose FVIII ITI appears to induce immune tolerance more rapidly than low - dose protocols and with a reduced risk of bleeding episodes . - pubmed
A large set of estrogen receptor beta - interacting proteins identified by tandem affinity purification in hormone - responsive human breast cancer cell nuclei . - pubmed
Estrogen receptors alpha ( ER - alpha ) and beta ( ER - beta ) play distinct biological roles in onset and progression of hormone - responsive breast cancer , with ER - beta exerting a modulatory activity on ER - alpha - mediated estrogen signaling and stimulation of cell proliferation by mechanisms still not fully understood . - pubmed
Functional annotation by bioinformatics analyses of the 303 proteins that co - purify with ER - beta from nuclear extracts identify several new molecular partners of this receptor subtype that represents nodal points of a large protein network controlling multiple processes and functions in breast cancer cells . - pubmed
This probably occurs by correcting diabetes - linked increased clearance of thiamine , maintaining activity and expression of thiamine pyrophosphate - dependent enzymes that help counter the adverse effects of high glucose concentrations - particularly transketolase . - pubmed
Thiamine supplementation prevented the development of early - stage nephropathy in diabetic rats and reversed increased urinary albumin excretion in patients with type 2 diabetes and microalbuminuria in two recent clinical trials . - pubmed
Visfatin is known to play a role in obesity - related metabolic diseases and inflammatory conditions . - pubmed
Here , the role of visfatin in FFA - induced inflammation was investigated in hepatocytes . - pubmed
The expression of visfatin is closely associated with the expression of proinflammatory cytokines in FFA - induced inflammation and is significantly decreased by NF - kappaB inhibition in HepG2 cells . - pubmed
Visfatin may play a role in FFA - induced inflammation in hepatocytes through the NF - kappaB pathway . - pubmed
IL-22 , but not IL-17 , dominant environment in cutaneous T - cell lymphoma . - pubmed
Recently , interleukin ( IL )- 22 - producing T cells were reported in skin of patients with AD . - pubmed
In this study , we investigated expression levels of T ( H ) 22 - and T ( H ) 17 - related molecules in lesional skin and sera isolated from patients with CTCL . - pubmed
Phosphorylation of STAT3 was also assessed in lesional skin of CTCL and psoriasis by immunohistochemistry . - pubmed
RESULTS : IL-22 , IL-10 , IL-4 , CCL20 , and CCR6 mRNA and protein levels , but not IL-17A , IL-17F , IL-23p19 , IL-8 , or IL-20 , were significantly elevated in lesional skin of CTCL . - pubmed
Phosphorylation of STAT3 was detected in epidermis of CTCL skin . - pubmed
Moreover , serum IL-22 , IL-10 , and CCL20 levels were increased in CTCL and correlated with disease severity . - pubmed
CONCLUSIONS : Our results suggest that IL-22 is important in establishing the tumor microenvironment for CTCL . - pubmed
Enhanced expression of CCL20 may explain epidermal hyperplasia and migration of CCR6(+ ) cells , such as Langerhans cells , into lesional skin . - pubmed
Relatively low expression of IL-17 may explain the lack of neutrophils in lesions of CTCL , which correlates with bacterial infections that commonly occur in skin affected by CTCL . - pubmed
[ Effect of acupuncture on contents of beta - endorphin in the plasma and hypothalamus in rats with stress - induced gastric mucosal injury ] . - pubmed
Compared with the corresponding model groups , the gastrointestinal propulsion rate was increased remarkably in the prevention group ( P & lt ; 0.05 ) , and the gastric mucosal ulcer indexes and the contents of plasma beta - EP level were decreased obviously in both treatment and prevention groups ( P & lt ; 0.05 , P & lt ; 0.01 ) . - pubmed
CONCLUSION : Acupuncture of ST 36 , CV 12 and PC 6 can promote the repair of gastric mucosal injury and improve gastrointestinal function , which may be related to its effects in reducing plasma beta - EP and upregulating hypothalamic beta - EP level . - pubmed
Monoamine oxidase - B ( MAO - B ) inhibitor has been used as neuroprotectants to treat the motor deficits of Parkinson ' s disease ( PD ) . - pubmed
IgG4 - Related Perineural Disease . - pubmed
Retrospective review of 106 patients with IgG4 - related disease identified 21 peripheral nerve lesions in 7 patients . - pubmed
IgG4 - related disease of the peripheral nervous system is characterized by orbital or paravertebral localization , perineural mass formation , and rare neurologic symptoms . - pubmed
The term " IgG4 - related perineural disease " seems appropriate to describe this entity . - pubmed
Treatment of CD4 + T cells with Virus - Like Particles ( VLP ) containing Vpx results in the loss of SAMHD1 expression that correlates with an increased permissiveness to HIV-1 infection and accumulation of reverse transcribed viral DNA without promoting transcription from the viral LTR . - pubmed
Importantly , CD4 + T - cells from patients with Aicardi - Goutieres Syndrome harboring mutation in the SAMHD1 gene display an increased susceptibility to HIV-1 infection that is not further enhanced by VLP - Vpx - treatment . - pubmed
These results highlight the crucial role of SAMHD1 in mediating restriction of HIV-1 infection in quiescent CD4 + T - cells and could impact our understanding of HIV-1 mediated CD4 + T - cell depletion and establishment of the viral reservoir , two of the HIV / AIDS hallmarks . - pubmed
METHODS : To evaluate the estrogenic effect of SG , we first examined estrogen receptor ( ER ) activation by SG treatment in breast adenocarcinoma cells and confirmed the estrogenic effect of SG in vivo ovariectomized rats . - pubmed
RESULTS : SG significantly increased ERalpha phosphorylation , and its downstream effectors , extracellular signal - regulated kinase ( ERK ) and protein kinase B ( Akt ) phosphorylation in breast adenocarcinoma cells . - pubmed
CONCLUSION : Taken together , these data indicate that SG has phytoestrogen - like properties through ERK and Akt activation , implying that it could be protective and beneficial for the management of menopausal symptoms . - pubmed
Significance of osteopontin in the sensitivity of malignant pleural mesothelioma to pemetrexed . - pubmed
High immunohistochemical expression of SPP1 / OPN was observed in two of three MPM patients who had a partial response to PEM - based chemotherapy . - pubmed
PEM has antitumor effects in MPM cells dependent on SPP1 / OPN overexpression resulting in AKT activation . - pubmed
Our results suggest that SPP1 may be used as a single predictive biomarker of the effectiveness of PEM treatment in MPM . - pubmed
Preventive effects of siRNA targeting PPARgamma gene on steroid - induced osteonecrosis in rabbits . - pubmed
UNLABELLED : PURPOSES / AIM : Glucocorticoid steroids can induce expression of PPARgamma gene and enhance adipogenesis by bone marrow mesenchymal stem cells ( BMSCs ) , which may result in osteonecrosis of the femoral head . - pubmed
We hypothesized that siRNA targeting PPARgamma gene may prevent steroid - induced adipogenesis and osteonecrosis in rabbit . - pubmed
The purpose of this study was to evaluate the preventive effects of siRNA targeting PPARgamma gene on steroid - induced adipogenesis and osteonecrosis . - pubmed
CONCLUSION : siRNA targeting PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent steroid - induced osteonecrosis in rabbit . - pubmed
The sptC gene encodes a precursor composed of a signal peptide , an N - terminal propeptide consisting of a core domain ( N * ) and a linker peptide , a subtilisin - like catalytic domain , a polycystic kidney disease domain ( PkdD ) , and a chitin - binding domain ( ChBD ) . - pubmed
Platelets , cyclooxygenases , and colon cancer . - pubmed
Activated platelets , in response to tissue damage , induce a proinflammatory program involving the aberrant expression of cyclooxygenase ( COX )- 2 , which leads to increased tissue concentrations of the proinflammatory and protumorigenic prostaglandin E2 . - pubmed
In the current study we evaluated the added value of a combined protocol of blood oxygen level dependent ( BOLD ) imaging during hyperoxic challenge ( termed hemodynamic response imaging ( HRI ) ) in an orthotopic mouse model for glioblastoma under anti - angiogenic treatment with B20 - 4.1.1 , an anti - VEGF antibody . - pubmed
In glioblastoma tumors , the elevated HRI indicated progressive angiogenesis as further confirmed by histology . - pubmed
Genetics : BCL11A - targeting triple - negative breast cancer ? - pubmed
Furthermore , PFO+ subjects had an increased incidence of acute mountain sickness ( AMS ) at ALT1 concomitant with significantly lower peripheral O2 saturation ( SpO2 ) . - pubmed
Dab2IP ( DOC-2 / DAB2 interacting protein ) is a GTPase - activating protein which is involved in various aspects of brain development in addition to its roles in tumor formation and apoptosis in other systems . - pubmed
Biochemical and Functional Comparisons of mdx and Sgcg(-/- ) Muscular Dystrophy Mouse Models . - pubmed
The mdx mouse , which is dystrophin - deficient , has long been used to model this disease . - pubmed
Histologically the Sgcg(-/- ) mice displayed increased fibrosis and variable fiber size . - pubmed
By quantitative Evan 's blue dye uptake and hydroxyproline content two key disease determinants , membrane permeability and fibrosis respectively , were also proven worse in the Sgcg(-/- ) mice . - pubmed
Abeta ( 1 - 40 ) peptide supramolecular assembly and fibril formation processes are widely recognized to have direct implications in the progression of Alzheimer ' s disease . - pubmed
Desflurane preconditioning protects human umbilical vein endothelial cells against anoxia / reoxygenation by upregulating NLRP12 and inhibiting non - canonical nuclear factor - kappaB signaling . - pubmed
Desflurane preconditioning enhanced HUVEC survival and protected the cells against A / R injury , and our results suggested that this process involved the upregulation of NLRP12 and the inhibition of non - canonical NF - kappaB signaling . - pubmed
BACKGROUND : Tissue factor ( TF ) is involved in tumor growth and metastasis and contributes to venous thromboembolism ( VTE ) in cancer , including gynecological malignancies . - pubmed
RESULTS : D - Dimer , MV TF PCA , and sCD62P , but not the tumor marker , CA-125 , significantly differentiated patients with malignant ( n=40 ) from those with benign tumors ( n=15 ) and healthy controls ( n=34 ) . - pubmed
In cancer patients , only D - Dimer and CA-125 correlated with the FIGO stage . - pubmed
CONCLUSIONS : MV TF PCA , but not plasma TF antigen , may provide valuable additional information for the diagnostic work - up of women with suspected ovarian cancer . - pubmed
TAMOF is a devastating microangiopathy that can occur in association with the new onset of T1DM , and should be considered with the onset of thrombocytopenia , renal failure , and raised LDH . - pubmed
Studies of CD40L - deficient patients reveal the critical role of CD40L - CD40 interaction for the function of T , B , and dendritic cells . - pubmed
METHODS : After observing the improvement of refractory disseminated mycobacterial infection in a CD40L - deficient patient by recombinant human IFN - gamma ( rhIFN - gamma ) adjuvant therapy , we investigated macrophage functions from CD40L - deficient patients . - pubmed
RESULTS : Macrophages from CD40L - deficient patients exhibited defective fungicidal activity and reduced oxidative burst , both of which improved in the presence of rhIFN - gamma but not sCD40L. - pubmed
In addition , the improvement of macrophage immune responses by IFN - gamma suggests this cytokine as a potential therapeutic option for patients with CD40L deficiency . - pubmed
The risk for PD in these groups does not linearly increase with glucosylceramide ( GC ) accumulation or with acid beta - glucocerebrosidase ( GCase ) activity . - pubmed
Incidence of human cytomegalovirus infection and T - cell response in patients with psoriasis before and during antitumour necrosis factor - alpha therapy . - pubmed
Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease . - pubmed
CD1 - pcy / pcy mice , a juvenile model of PKD , daily treated with 13 [ Formula : see text]g of mambaquaretin-1 for 99 d , developed less abundant ( by 33 % ) and smaller ( by 47 % ) cysts than control mice . - pubmed
Significant reductions in the phosphorylation of signaling molecules focal adhesion kinase , extracellular signal - regulated kinases 1 and 2 , and v - Akt murine thymoma viral oncogene were observed in male MIPbeta1KO islets when compared to controls . - pubmed
Female MIPbeta1KO mice did not develop glucose intolerance or reduced beta - cell mass until 16 weeks post - tamoxifen . - pubmed
Glucose intolerance remained in both genders of aged MIPbeta1KO mice . - pubmed
Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection . - pubmed
Examination of NLRP3 inflammasome expression illustrated decreased NLRP3 mRNA expression and decreased IL1beta production in aged lung in response to secondary S. pneumoniae infection . - pubmed
Long noncoding RNA LINC01510 promotes the growth of colorectal cancer cells by modulating MET expression . - pubmed
Long intergenic non - protein coding RNA 1510 , an enhancer lncRNA ( LINC01510 ) , a lncRNA enhancer is upregulated in colorectal cancer ( CRC ) , and its expression might relate to MET as revealed by lncRNA microarray data . - pubmed
Results : In the present study , we found that LINC01510 was significantly upregulated in CRC tissues and cell lines . - pubmed
Meanwhile , gain- and loss - of - function assays demonstrated that LINC01510 overexpression increased CRC cell proliferation , and promoted cell cycle progression from the G1 phase to the S phase . - pubmed
Conclusions : Taken together , our findings suggested that upregulation of LINC01510 contributes to the proliferation of CRC cells , at least in part , through the regulation of MET protein . - pubmed
Increased follicular atresia was evident in NeurARKO ovaries with a 4 - fold increase in unhealthy large preantral follicles ( p & lt ; 0.01 ) . - pubmed
[ Effects of peroxisome proliferator - activated receptor gamma - toll - like receptor 4 - tumor necrosis factor - alpha targeted pathway on hyperglycemia induced myocardium inflammation and oxidative stress ] . - pubmed
OBJECTIVE : To investigate the potential effects and mechanism on peroxisome proliferator - activated receptor gamma - toll - like receptor 4 - tumor necrosis factor - alpha ( PPARgamma - TLR4 - TNF - alpha ) targeted pathway on hyperglycemia induced myocardium inflammation and oxidative stress . - pubmed
CONCLUSIONS : 4 mgxkg-1xd-1 pioglitazone could activate PPARgamma - TLR4 - TNF - alpha targeted pathway , thus inhibit inflammatory and oxidative stress factors expression , and down - regulate hyperglycemia induced myocardium inflammatory and oxidative stress level , but the effect did not show a dose dependent manner . - pubmed
Oxidative stress and NF - kappaB signaling are involved in LPS induced pulmonary dysplasia in chick embryos . - pubmed
LPS treatment also resulted in reduced CAV-1 expression and up - regulation of Collagen I , suggesting increased lung fibrosis , which was verified by Masson staining . - pubmed
Background : Bevacizumab is a recombinant humanised monoclonal antibody to vascular endothelial growth factor shown to improve survival in advanced solid cancers . - pubmed
Forty four percent of 682 melanomas assessed had a BRAFV600 mutation . - pubmed
[ PD - L1 - Mediated Immune Escape Mechanism of Cancer Stem - Like Cells ] . - pubmed
In this review article , we summarize the expression of PD - L1 , a molecular target of ICIs , in CSCs , and discuss the possibility of CSC - targeting immunotherapy using ICIs . - pubmed
Here , we investigated kidney function of a novel gene associated with nephronophthisis , CEP164 , coding a centriolar distal appendage protein , using a Cep164 knockout mouse model . - pubmed
Immunotherapy with T cells expressing chimeric antigen receptors ( CAR ) is an emerging and promising treatment against refractory cancers . - pubmed
Factors Associated with the Need for Insulin as a Complementary Treatment to Metformin in Gestational Diabetes Mellitus . - pubmed
OBJECTIVE : To evaluate the factors associated with the need for insulin as a complementary treatment to metformin in pregnant women with gestational diabetes mellitus ( GDM ) . - pubmed
CONCLUSION : Obesity resulted in an increased chance of the mother needing insulin as a complementary treatment to metformin , while FG & lt ; 90 mg / dL and primiparity were protective factors . - pubmed
Early outcomes with utilization of tissue plasminogen activator in COVID-19 - associated respiratory distress : A series of five cases . - pubmed
The anti - proliferative activity of ursolic acid in MDA - MB-231 human breast cancer cells through Nrf2 pathway regulation . - pubmed
The potential mechanisms of action of ursolic acid ( UA ) in regulating cell proliferation in MDA - MB-231 human breast cancer cells through Nrf2 pathway were investigated . - pubmed
There were 15 subjects with MAPT H1 / H1 and 11 subjects with MAPT H1 / H2 within PD - MCI , and 33 subjects with MAPT H1 / H1 and 19 subjects with MAPT H1 / H2 within all PD . - pubmed
Further , the subgroup of PD patients carrying the risky MAPT H1 / H1 haplotype was compared with noncarriers ( MAPT H1 / H2 haplotype ) in terms of CBF by a two - sample t test . - pubmed
Additionally , the PD patients with MAPT H1 / H1 haplotype had decreased perfusion than the ones with H1 / H2 haplotype at the posterior areas of the visual network ( VN ) , default mode network ( DMN ) , and dorsal attention network ( DAN ) . - pubmed
Targeting IL-1beta in the Treatment of Atherosclerosis . - pubmed
Compared with other cytokines , interleukin-1beta ( IL-1beta ) is associated with acute and chronic inflammation . - pubmed
The results of CANTOS suggested an important role of IL-1beta in atherosclerosis . - pubmed
We herein discussed the important immunomodulatory effect IL-1beta exerts on atherosclerosis and the potential mechanisms underlying it . - pubmed
We also reviewed bench - to - bedside clinical translation of IL-1beta neutralizing strategies associated with the use of IL-1beta blockade in patients with atherosclerosis . - pubmed
This significantly contributed to the pathogenesis in AAA , whereas overactive Transforming growth factor - beta played a major role in the pathogenesis of TAA . - pubmed
The allelic frequencies at 6 isozyme loci ( Es-1 , Es-2 , Es-3 , Es-4 , Es - Si and Amy-1 ) were examined in 4 outbred Wistar strains and additionally 2 SD strains as controls . - pubmed
The possible roles for phospholipases in lamellar body development and in the respiratory distress syndrome of the newborn are discussed . - pubmed
Plasma elastase levels were estimated in 190 patients of both sexes above the age of 65 with the exception of one male subject with prostatic carcinoma who was 51 years of age . - pubmed
Human rotavirus strain Ro1845 , which was isolated in 1985 from an Israeli child with diarrhea , has a hemagglutinin that is capable of agglutinating erythrocytes from guinea pigs , sheep , chickens , and humans ( group O ) . - pubmed
Patients with a diagnostic biopsy , as compared to patients with a nondiagnostic biopsy , had a statistically significant increase in the frequency of having AIDS diagnosed before the biopsy , longer duration of AIDS ( in patients with AIDS diagnosed before the biopsy ) , greater number of different prior opportunistic infections , and a more elevated serum alkaline phosphatase level . - pubmed
In particular , the 15 patients with hepatic mycobacterial infection , as compared to the other patients , had a statistically significant increase in the frequency of having AIDS diagnosed prior to the biopsy , longer duration of AIDS , more frequent prior opportunistic infections , more severe leukopenia , and a more elevated serum alkaline phosphatase level . - pubmed
[ A study on serum creatine phosphokinase and type A behavior in schizophrenia ] . - pubmed
The CPK levels of 79 patients with schizophrenia ( 36 males and 43 females and 88 normal control subjects ( 53 males and 35 females ) were assessed . - pubmed
The result shows that the CPK level of the patients with acute schizophrenia ( 307.33 Iu / L ) was significantly higher than that of the normal control subjects ( 160.51 Iu / L ) ( t = 3.534 , N21 , 88 , P less than 0.01 ) and the CPK level of male schizophrerines rose more significantly . - pubmed
Association between DR antigens and the occurrence of cytotoxic alloantibodies was studied in 251 patients on dialysis . - pubmed
Leucocyte superoxide dismutase levels in acute and chronic leukemias . - pubmed
Superoxide dismutase " SOD " enzyme levels in leucocytes of patients with acute and chronic leukemia , were measured by using Misra and Fridovich 's epinephrine method . - pubmed
In all types of leukemia , the SOD levels were found to be significantly higher than normals . - pubmed
No relationship was found between the SOD level and types of leukemia . - pubmed
Nine of ten SLE patients exhibited significant impairment of IgG suppression but no correlation was found between the outcome of the IgG suppressor cell assay and disease activity or the treatment protocol applied . - pubmed
By means of ultrasonography , arterial wall stiffness , arterial wall thickness , and the elastic modulus of the common femoral artery were estimated in a group of 19 young insulin - dependent diabetics . - pubmed
We suggest that urokinase , presumably released by the activated proliferating histiocytes , may play a major role in the extracellular matrix degradation leading to erosion of cartilage and adjacent bone in multicentric reticulohistiocytosis . - pubmed
Nippostrongylus brasiliensis - induced depression of heterologous immune responses : effects of the histamine H2 receptor antagonist , cimetidine . - pubmed
Intravascular coagulation and plasma fibrinogen in pregnancy . - pubmed
Rehydration as a diagnostic and therapeutic measure in hypercalcemia including an assessment of the calcium - lowering effect of porcine calcitonin . - pubmed
[ Cryoglobulinemia with gamma 1A , gamma 1 M multiple paraproteinemia ] . - pubmed
We conclude that bromocriptine , given to patients with polycystic ovarian disease , inhibits LH hypersecretion , leading to restoration of cyclic ovarian function and reduced androgen synthesis . - pubmed
In vitro stimulated peripheral blood lymphocytes from multiple sclerosis patients produce idiotypes of oligoclonal CSF IgG. - pubmed
Anti - idiotypic ( anti - Id ) antisera prepared against IgG from the cerebrospinal fluid of patients with multiple sclerosis were used to analyze culture supernatants of in vitro stimulated peripheral blood lymphocytes ( PBL ) from the patients . - pubmed
This finding provides additional evidence that the production of oligoclonal IgG in multiple sclerosis is not exclusively a feature of the central nervous system , but is also a systemic immunologic phenomenon . - pubmed
It is concluded that female rats are less susceptible to CCl4 - -alcohol - induced liver damage , especially hydroxyproline accumulation , which is explained by the known fact that females are more resistant against CCL4 - hepatotoxicity as a consequence of a minor role of bioactivation in the metabolic degradation of CCL4 by females . - pubmed
After injection of the antibodies in rats , diffuse granular deposits of rabbit IgG , typical of passive Heymann nephritis , were detected along the glomerular capillary walls . - pubmed
These antigens are major glycoproteins of the BB membranes and appear to be associated with the nephritogenic antigens of passive Heymann nephritis . - pubmed
Integrated regulation of very low density lipoprotein triglyceride and apolipoprotein - B kinetics in non - insulin - dependent diabetes mellitus . - pubmed
Turnover rates of plasma very low density lipoprotein ( VLDL ) triglyceride ( TG ) and apolipoprotein - B ( apo - B ) were significantly increased in age- and weight - matched groups of normolipemic and hyperlipemic mild diabetics , and hyperlipemic moderately severe diabetics when compared with normolipemic controls . - pubmed
As in the normolipemic subjects , a significant correlation between VLDL TG and apo - B turnover rates was found in all diabetic groups , suggesting that integration of TG and apo - B production at synthetic and/or secretory sites is retained in diabetes , thus resulting in increased secretion of VLDL particles of normal composition . - pubmed
In normolipemic mild diabetic subjects , the fractional turnover rates of VLDL TG and apo - B were also significantly increased so that increased removal accompanied increased VLDL production . - pubmed
In the hyperlipemic diabetics , however , the fractional turnover rates were significantly reduced , hence the increased in VLDL removal was not sufficient to compensate for enhanced production . - pubmed
In normolipemic mild diabetic patients , low density lipoprotein ( LDL ) formation was increased , only a small fraction of VLDL apo - B being removed via a non - LDL pathway , presumably as remnant VLDL . - pubmed
In hyperlipemic mild diabetics , removal of VLDL apo - B via both the LDL and non - LDL pathways was increased . - pubmed
In hyperlipemic moderately severe diabetes , LDL formation was not increased ; catabolism of VLDL apo - B through the non - LDL route was however , fivefold greater than normal . - pubmed
We conclude that increased VLDL secretion is a fundamental defect in non - insulin - dependent diabetes . - pubmed
The increase in LDL and/or VLDL remnant formation , regardless of prevailing plasma lipid levels or the severity of diabetes , provides a source of cholesterol which may account for the atherogeneity of this disorder . - pubmed
STUDY OBJECTIVES : To measure interleukin-1 beta ( IL-1 beta ) levels in pleural effusions of different etiologies and their relationship with several pleural inflammatory parameters , and to verify whether IL-1 beta can be used as diagnostic marker in the differential diagnosis of pleural diseases . - pubmed
RESULTS : IL-1 beta was above 200 pg / mL in all the patients with empyema but only in three patients with other etiologies . - pubmed
As a diagnostic criterion for empyema , pleural IL-1 beta concentration greater than 200 pg / mL had a sensitivity of 100 % , a specificity of 96 % , and a positive and negative predictive value of 0.82 and 1 , respectively . - pubmed
CONCLUSIONS : Our data suggest that IL-1 beta has a significant role in pyogenic infections of the pleural space but not in effusions of other etiologies . - pubmed
Increased hypoxia has been found after beta 2 adrenoceptor agonists ( but not adrenaline ) in asthmatics . - pubmed
An RNA polymerase I core promoter binding factor ( CPBF ) was purified to apparent homogeneity from rat adenocarcinoma ascites cells by chromatographic fractionation on a series of columns including an oligodeoxynucleotide affinity column . - pubmed
Interferons ( IFNs ) are families of cytokines which have been discovered and extensively characterized in the context of host defense against viral infections . - pubmed
We describe a PCR - based assay for determining c - erbB-2 oncogene amplification in breast cancer in which we use the TaqMan system . - pubmed
This homogeneous assay is time - saving , avoids usually cumbersome postamplification procedures ( that can be additional sources of inaccuracy and contamination ) , and seems suitable for determination of c - erbB-2 oncogene amplification in tumor specimens . - pubmed
Treatment of chronic hepatitis C with interferon - alpha . - pubmed
OBJECTIVE : to identify pretreatment predictive factors of long - term biochemical and virological response to interferon - alpha in chronic hepatitis C and to determine the effects of a second course of interferon - alpha in patients who responded but relapsed after interferon withdrawal . - pubmed
PATIENTS : 112 patients with chronic hepatitis C were treated with recombinant interferon - alpha ( 3 MU three times a week for 6 months ) . - pubmed
We found : ( a ) a point mutation and loss of the specific activity of the tumor suppressor gene p53 without alteration of the apoptotic response to transforming growth factor beta1 ; ( b ) a gradual decrease of retinoblastoma protein , which was constantly present , mainly in a hyperphosphorylated form ; and ( c ) an increase of cyclin - dependent kinase inhibitor p27 expression in confluent differentiating cells , as expected , whereas , surprisingly , a disappearance of the p21 protein was observed in parallel . - pubmed
Detection of circulating cancer cells by nested reverse transcription - polymerase chain reaction of cytokeratin-19 ( K19)--possible clinical significance in advanced gastric cancer . - pubmed
Intermediate filament cytokeratin-19 ( K19 ) protein is expressed in normal and malignant gastrointestinal epithelial cells , but not in peripheral blood ( PB ) . - pubmed
Small amount of circulating gastric cancer cells can be detected by a sensitive nested reverse transcription - polymerase chain reaction ( RTPCR ) with primers specific for K19 mRNA . - pubmed
None of the other pertinent clinicopathological features , including the disease extent and the histopathologic types of the tumors , were related to the expression of K19 in PB . - pubmed
However , the survival impact of K19 was less significant in the other 17 patients whose tumors had responded to systemic chemotherapy . - pubmed
We concluded that detecting circulating cancer cells by K19 nested RT - PCR is associated with poor prognosis of gastric cancer , particularly in those patients who are not responsive to systemic chemotherapy . - pubmed
Evidence that an HLA - DQA1 - DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection - related aetiology . - pubmed
Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia ( c - ALL ) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1 * 0101/*0104 and DQB1 * 0501 than appropriate control subjects . - pubmed
Levodopa induces a cytoplasmic localization of D1 dopamine receptors in striatal neurons in Parkinson ' s disease . - pubmed
Mutations in the CNGB3 gene encoding the beta - subunit of the cone photoreceptor cGMP - gated channel are responsible for achromatopsia ( ACHM3 ) linked to chromosome 8q21 . - pubmed
While mutations in the CNGA3 gene on chromosome 2q11 are responsible for achromatopsia in a subset of patients , previous linkage studies have localized another achromatopsia locus , ACHM3 , on chromosome 8q21 . - pubmed
Using achromatopsia families in which CNGA3 mutations have been excluded , we refined the ACHM3 locus to a 3.7 cM region enclosed by markers D8S1838 and D8S273 . - pubmed
In this study , we performed immunostaining for CK , EMA , HBME , CD57 and CD15 in PTC , and benign thyroid nodular lesions to compare the sensitivity and the specificity of these antisera for PTC . - pubmed
Fifty - five PTC ( composed of 30 papillary variants and 25 follicular variants ) , 5 follicular carcinomas , 30 follicular adenomas , and 20 thyroid nodular lesions ( 5 papillary variants and 15 follicular variants ) were submitted for immunostaining with CK , EMA , HBME , CD57 , and CD15 . - pubmed
CK and HBME showed the highest sensitivity and specificity for PTC when an arbitrary cutoff of more than 10 % positive cells was considered as positive diagnostic immunostaining for these sera . - pubmed
One case of PTC showed negative HBME but positive CD15 , whereas three papillary variants and two follicular variants of benign thyroid nodules revealed a positive diagnostic HBME immunostaining for PTC and negative CK immunostaining . - pubmed
Any combination of positive diagnostic immunostaining with CK+ HBME , CK+ CD57 or CK+ CD15 has a sensitivity of 95 % and specificity of 90 % for PTC . - pubmed
Three of five follicular carcinomas showed negative reactivity for HBME , CD57 , and CD15 . - pubmed
A combination of immunostaining with CK , HBME and CD57 ( or CD15 ) is a sensitive and specific test for PTC . - pubmed
Effects of growth hormone treatment on red cell plasma membrane fatty acid constituents in hypopituitary adults . - pubmed
The effects of replacement with recombinant human GH ( hGH ) on red cell plasma membrane fatty acid and cholesterol constituents were assessed in nine adult patients with growth hormone deficiency . - pubmed
NF - kappa B does not modulate sensitivity of renal carcinoma cells to TNF alpha - related apoptosis - inducing ligand ( TRAIL ) . - pubmed
BACKGROUND : Immune cells express TNF - related apoptosis - inducing ligand ( TRAIL ) and may play an important role in controlling the growth of renal cancer . - pubmed
RESULTS : Two RCC lines were highly sensitive to TRAIL - induced cell death , two were of intermediate sensitivity , and two were insensitive . - pubmed
CONCLUSIONS : NF - kappa B , although stimulated in these cell lines , does not play a role in the sensitivity of RCC to TRAIL and could play other functions in TRAIL signaling . - pubmed
Genomic characterization of human SEC14L1 splice variants within a 17q25 candidate tumor suppressor gene region and identification of an unrelated embedded expressed sequence tag . - pubmed
We more precisely mapped SEC14L1 within a discrete region of 17q25 that likely harbors at least one putative breast and ovarian tumor suppressor gene . - pubmed
As retinoids have been shown to inhibit the growth of breast cancer cells , loss of the proposed SEC14L1 retinal - binding function may contribute to breast tumorigenesis . - pubmed
As TTPA and CRALBP have been implicated in retinitis pigmentosa ( RP ) , altered SEC14L1 expression may contribute to RP in previously unlinked families . - pubmed
Recessively inherited mutations in the HFE gene are responsible for iron accumulation in most cases of hereditary haemochromatosis and may have a role in HCV infection . - pubmed
AIMS : To assess the prevalence of HFE mutations in Scottish HCV infected patients and to explore the effect of the carrier state on serum and liver iron stores , and the severity of liver disease . - pubmed
Carriage of HFE mutations , although frequently observed in these HCV infected patients , does not have a role in the accumulation of iron or the progression of liver disease in HCV infection . - pubmed
Expression of BLM ( the causative gene for Bloom syndrome ) and screening of Bloom syndrome . - pubmed
The causative gene for BS is the BLM gene which encodes the BLM RecQ helicase protein . - pubmed
The detection of BLM gene mutations for laboratory diagnosis of BS is laborious and impractical , unless there are common mutations in a population . - pubmed
The BLM protein was not detected in EBV - transformed lymphoblasts from three BS patients . - pubmed
However , in lymphoblasts from BS patients no nuclear dots of the BLM protein were detected . - pubmed
The expression of beta2 - adrenergic receptors ( beta2 - R ) on B lymphocytes and agonist - induced cAMP production is reduced in patients with rheumatoid arthritis ( RA ) . - pubmed
To further study functional consequences of the diminished beta2 - R density on B lymphocytes in RA patients , agonist - induced cell death was evaluated and compared to healthy controls . - pubmed
B lymphocytes from patients with RA and healthy controls were activated with anti - IgM - antibody . - pubmed
Apoptotic and necrotic cells were determined using Annexin - V and propidium - iodide staining . - pubmed
However , in RA patients the increase in cell death following beta2 - R stimulation ( 21.8 + /- 8.9 % ) was significantly impaired ( p = 0.02 ) . - pubmed
Our data demonstrate that catecholamine - induced cell death after stimulation of beta2 - R on B lymphocytes is decreased in RA patients , possibly contributing to the pathogenesis of the disease . - pubmed
To identify inhibitors of the intrinsic N - acetylated alpha - linked acidic dipeptidase ( NAALADase ) activity of prostate specific membrane antigen ( PSMA ) that may be useful for targeting imaging agents or chemotherapeutic drugs to disseminated prostate cancer , analogs of the tetrahedral transition state for hydrolysis of the natural substrate , N - acetylaspartylglutamate ( NAAG ) , were synthesized . - pubmed
Mutations in the Recql4 gene are very likely responsible for a subset of Rothmund - Thomson syndrome ( RTS ) cases , but until now there has been no animal model to confirm this . - pubmed
Knockout mice in which the Recql4 gene is disrupted at exons 5 - 8 exhibit embryonic lethality at embryonic day 3.5 - 6.5 . - pubmed
The exon 13 - deleted Recql4 - deficient mice are viable , but exhibit severe growth retardation and abnormalities in several tissues , and embryonic fibroblasts show a defect in cell proliferation . - pubmed
Abnormalities in the Recql4 - deficient mice are similar to those in RTS patients , suggesting that defects in the Recql4 gene may indeed be responsible for RTS . - pubmed
CD14 - positive cells cultured in the presence of PSK significantly increased the expression of HLA class II antigen and CD40 ; significantly increased the number and expression of CD80- , CD86- and CD83 - positive cells ; decreased Fluorescein isothiocyanate ( FITC)-dextran uptake , augmented IL-12 production ; augmented the allogeneic mixed lymphocyte reaction ; and induced antigen - specific cytotoxicity . - pubmed
To date there have been limited studies of HSA21 gene expression in trisomy 21 conceptuses . - pubmed
Since non - HSA21 antioxidant genes are reported to be concomitantly upregulated in certain DS tissues , we examined the expression of glutathione peroxidase-1 ( GPX1 ) in control and DS fetal organs . - pubmed
Interestingly , GPX1 expression was unchanged in the majority of DS organs and decreased in DS livers . - pubmed
The diagnosis and treatment of prostate cancer have been dramatically improved due to the development of PSA screening , transrectal ultrasonography and new anti - androgen drugs , such as LH - RH analog , with fewer side effects . - pubmed
In the present study , we provide evidence that the hypertrophic agonist , phenylephrine ( PE ) , promotes phosphorylation of CREB in adult rat cardiac myocytes through alpha ( 1 )- and beta - adrenergic receptors . - pubmed
The same pathways seem to regulate atrial natriuretic peptide ( ANF ) mRNA expression , a highly conserved marker gene of cardiac hypertrophy , suggesting that the PE - stimulated activation of CREB is likely to play an important role in the hypertrophic response . - pubmed
with the breast cancer cells and syngeneic / allogeneic - transfected fibroblasts modified to secrete IL-2 survived significantly longer ( P & lt ; .005 ) than mice in various control groups , including mice injected i.c . - pubmed
Botulinum toxin A for treatment of neurogenic detrusor overactivity and incontinence in patients with spinal cord lesions . - pubmed
OBJECTIVE : To evaluate the efficacy of intravesical botulinum toxin A ( BTA ) in the treatment of severe neurogenic detrusor overactivity ( NDO ) with incontinence in patients with spinal cord lesions ( SCLs ) . - pubmed
Curcumin blocks HIV protease inhibitor ritonavir - induced vascular dysfunction in porcine coronary arteries . - pubmed
BACKGROUND : HIV protease inhibitor ritonavir ( RTV ) is associated with many cardiovascular complications and causes vascular dysfunction through oxidative stress . - pubmed
[ PPARgamma and colon cancer ] . - pubmed
Leptin as a common link to obesity and hypertension . - pubmed
While the relevance of endogenous leptin needs further clarification , it appears to be a potential pressure- and volume - regulating factor , and may function pathophysiologically as a common link to obesity and hypertension . - pubmed
The association with HLA - B27 is less strong in IBD - associated AS than in idiopathic AS , and there is evidence for an association between gut inflammation in AS with the Crohn 's - disease - related CARD15 mutations . - pubmed
Major advances have been made in recent years with the establishment of anti - tumour necrosis factor ( TNF ) therapy in AS , the other spondyloarthritides and IBD . - pubmed
Anti - TNF agents are of particular relevance to AS patients with concomitant IBD who are at risk of exacerbation of the underlying bowel disease when treated with NSAIDs . - pubmed
Plasma retinol - binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes . - pubmed
Retinol - binding protein-4 ( RBP4 ) , a new adipokine , was recently reported to provide a link between obesity and insulin resistance . - pubmed
RESEARCH DESIGN AND METHODS : An enzyme - linked immunosorbent assay was developed to measure human RBP4 plasma concentrations , which were then compared with various parameters related to insulin resistance in subjects with normal glucose tolerance ( NGT ; n = 57 ) , impaired glucose tolerance ( IGT ; n = 48 ) , and type 2 diabetes ( n = 49 ) . - pubmed
RESULTS : Plasma RBP4 concentrations were higher in the IGT and type 2 diabetic groups than in the NGT group ( median 18.9 [ range 11.2 - 45.8 ] , 20.9 [ 9.9 - 48.5 ] , and 18.1 microg / ml [ 9.3 - 30.5 ] , respectively ) . - pubmed
However , no difference was found between plasma RBP4 concentrations in the IGT and type 2 diabetic groups . - pubmed
Plasma RBP4 concentrations were found to be associated with sex , waist circumference , fasting plasma glucose , and insulin resistance . - pubmed
CONCLUSIONS : Plasma RBP4 concentrations were found to be elevated in subjects with IGT or type 2 diabetes and to be related to various clinical parameters known to be associated with insulin resistance . - pubmed
However , both MAPK and NF - kappaB are also stimulated by exercise , which promotes improvements in fuel homeostasis and can prevent skeletal muscle atrophy . - pubmed
RESULTS : Lipoatrophy was associated with higher triglycerides ( 330 vs 133 mg / dl , p = 0.0003 ) , lower HDL ( 33 vs 48 mg / dl , p = 0.02 ) , and a greater frequency of hypercholesterolemia ( total cholesterol & gt ; 200 mg / dl ; 64 % vs 23 % , p & lt ; 0.03 ) . - pubmed
Adiponectin was 53 % lower in patients with lipodystrophy ( 6.9 microg / ml vs 14.8 microg / ml , p = 0.005 ) , however there was no difference in the inflammatory markers soluble TNFa receptor 2 or interleukin 6 . - pubmed
[ Development of a novel ADAMTS13 activity assay for diagnosis of TMA and criteria for judgment of platelet transfusion ] . - pubmed
ADAMTS13 specifically cleaves unusually large von Willebrand factor ( VWF ) multimers , which induce platelet thrombi formation under high shear stress . - pubmed
The determination of plasma levels of ADAMTS13 activity is prerequisite for a differential diagnosis of thrombotic microangiopathies ( TMAs ) . - pubmed
The plasma antigen level of ADAMTS13 has generally good correlate to the plasma activity , but the several samples from acquired TTP patients with below 3 % activity showed apparently high antigen level from 5 to 30 % . - pubmed
[ Expression of focal adhesion kinase in cardiac myocytes of hypertrophic ventricle ] . - pubmed
OBJECTIVES : To investigate the role of focal adhesion kinase ( FAK ) in the pathogenesis of cardiac hypertrophy induced by hypertension . - pubmed
METHODS : Using immunofluorescent labeling , confocal microscopy and Western blotting , the expression and subcellular localization of FAK in the cardiac myocytes of left ventricle were determined in 2 , 6 , 12 , and 18 month - old rats with spontaneously hypertensive heart failure ( SHHF ) along with age - matched control Wistar - Kyoto ( WKY ) rats . - pubmed
CONCLUSIONS : FAK may play a role in the cell signaling transduction leading to cardiac hypertrophy , presumably through regulations of hypertrophic gene transcription and RNA processing . - pubmed
Pharmacological subversion of the S1P rheostat is proving to be clinically efficacious in multiple sclerosis , and both the scope and limitations of therapeutic modulation of the S1P axis in immunotherapy are becoming clearer as understanding of the integrated chemical physiology of the S1P system emerges . - pubmed
To avoid ovarian dysfunction , synthetic peptides corresponding to ZP glycoproteins have been proposed as candidate immunogens . - pubmed
CONCLUSION : The observed degree of coding sequence homology in LRP5 led us to expect that the baboon may serve as a useful model for future research into the role(s ) of this gene in primate metabolic diseases . - pubmed
While baseline learning and memory were unaffected by reduction of gamma2 containing GABA ( A ) receptors , ethanol dose - dependently impaired spatial memory equally in gamma2 heterozygous knockouts and wild type littermate controls . - pubmed
The conversion of the prion protein ( PrP ) from its cellular form , PrPC , to its pathogenic scrapie form , PrPSc , is a key event in neurodegenerative transmissible spongiform encephalopathies such as Creutzfeldt - Jakob disease ( CJD ) . - pubmed
One working hypothesis for TSE causation is that oligomeric forms of PrP are the proximate neurotoxic agents . - pubmed
To gain insights into these intermediates , we have studied PrP125 - 228 and its CJD - causing T183A variant in their monomer and dimer forms by means of coarse - grained protein molecular dynamics simulations . - pubmed
Neutrophil gelatinase - associated lipocalin ( NGAL ) in human neoplasias : a new protein enters the scene . - pubmed
The small 25 kDa peptide , neutrophil gelatinase - associated lipocalin ( NGAL ) , first known as an antibacterial factor of natural immunity , and an acute phase protein , is currently one of the most interesting and enigmatic proteins involved in the process of tumor development . - pubmed
The aim of the present review is to point out the main contradictory , sometimes even paradoxical , effects attributed to NGAL in human neoplasias . - pubmed
For instance , acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation , NGAL has a clear pro - tumoral effect , as has already been observed in different tumors ( e.g. - pubmed
Moreover , in thyroid carcinomas , NGAL is strongly induced by NF - kB , an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development . - pubmed
However , on the contrary , some studies have demonstrated that NGAL can inhibit the pro - neoplastic factor HIF-1alpha , FA - Kinase phosphorylation and also VEGF synthesis , thus suggesting that , in alternative conditions , NGAL also , paradoxically , has an anti - tumoral and anti - metastatic effect in neoplasias of , for example , the colon , ovary and pancreas . - pubmed
Because inheritance of the apoE4 allele is the strongest known genetic risk factor for Alzheimer disease , the reduced neuroprotection afforded by apoE4 - containing LpE might contribute to the neurodegeneration characteristic of this disease . - pubmed
However , a completely different mechanism may be operating in major depression , where the increased levels of glucocorticoid hormones are conceptualized as driven by an impairment in GR function ( glucocorticoid resistance ) , and therefore as a " compensatory " mechanism . - pubmed
{ alpha } 7 - nAChR - mediated suppression of hyperexcitability of colonic dorsal root ganglia neurons in experimental colitis . - pubmed
Overall , our findings suggest that nicotine at low 1 microM concentration suppresses in vitro hyperexcitability of inflamed colonic DRG neurons in a mouse model of acute colonic inflammation via activation of alpha ( 7 )- nAChRs . - pubmed
Changes in hormones , including testosterone , estrogen , cortisol , vasopressin , and prolactin , during the postpartum period in fathers may be biological risk factors in paternal PPD . - pubmed
We and others have previously shown that hyperactivation of the c - Kit pathway in an Nf1 haploinsufficient microenvironment is required for both tumor formation and progression . - pubmed
These studies identify the p21 ( Ras )- PI3 K pathway as a major regulator of the gain in Nf1(+/- ) mast cell degranulation in neurofibromas . - pubmed
Collectively , these studies identify both c - Kit and PI3 K as molecular targets that modulate mast cell functions in cases of NF1 . - pubmed
Previous studies of the association of the C17 T polymorphism of the mu opiate receptor gene with substance dependence compared cases with substance dependence to controls and usually found no significant association . - pubmed
Angiotensin - converting enzyme 2 is a key modulator of the renin - angiotensin system in cardiovascular and renal disease . - pubmed
RECENT FINDINGS : ACE2 deficiency is associated with elevated tissue and circulating levels of angiotensin II and reduced levels of angiotensin 1 - 7 . - pubmed
In atherosclerosis - prone apolipoprotein E knockout mice , ACE2 deficiency results in augmented vascular inflammation and an inflammatory response that contributes to increased atherosclerotic plaque formation . - pubmed
In the kidney , ACE2 deficiency is associated with progressive glomerulosclerosis . - pubmed
Interventions such as ACE2 replenishment or augmentation of its actions have proven successful in reducing hypertension , plaque accumulation , and renal and cardiac damage in a range of different models . - pubmed
SUMMARY : Repletion of ACE2 's activities offers a new strategy to complement current clinical interventions in treating hypertension , renal and cardiovascular disease . - pubmed
Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma . - pubmed
CONCLUSION : Matrix metalloproteinase ( MMP )- 20 is overexpressed in laryngeal squamous cell carcinoma ( LSCC ) compared with the adjacent normal laryngeal epithelium and MMP-20 plays a role in lymph node metastasis . - pubmed
All the findings indicate that MMP-20 may play a role in the initiation and progression of LSCC . - pubmed
OBJECTIVE : The MMPs are a gene family of zinc - dependent endopeptidases that have been implicated in tumor invasion and metastasis , and MMP-20 is a new member of the MMP family . - pubmed
The purpose of this study was to investigate whether MMP-20 is overexpressed in human LSCC and , if so , the significance of its overexpression in relation to clinical parameters . - pubmed
RESULTS : We found that MMP-20 is overexpresssed in LSCC compared with the adjacent normal laryngeal epithelium . - pubmed
Invariant NKT cells producing IL-4 or IL-10 , but not IFN - gamma , inhibit the Th1 response in experimental autoimmune encephalomyelitis , whereas none of these cells inhibits the Th17 response . - pubmed
Invariant NKT ( iNKT ) cells prevent EAE in an IL-4- , IL-10- , and IFN - gamma - dependent manner . - pubmed
However , which of the iNKT cell - produced cytokines regulates the Th1 or Th17 response in EAE remains unclear . - pubmed
Clinical scores for EAE , IL-17 , and IFN - gamma transcript levels , and IL-17- or IFN - gamma - expressing CD4(+ ) T cell percentages in the CNS and draining lymph nodes were higher in Jalpha18(-/- ) than in B6 mice , but all of these parameters in the CNS were reduced by the adoptive transfer of wild - type or IFN - gamma - deficient iNKT cells into the Jalpha18(-/- ) mice before immunization . - pubmed
Taken together , IL-4- and IL-10 - producing iNKT cells inhibit the Th1 cell response , but not the Th17 cell response , although wild - type iNKT cells suppress both the Th1 and Th17 responses in the CNS during EAE . - pubmed
Moreover , IFN - gamma - producing iNKT cells have a minimal role in the regulation of the Th1 and Th17 responses in EAE . - pubmed
Association of CYP19 gene polymorphism with vertebral fractures in Japanese postmenopausal women . - pubmed
We explored the relationship between CYP19 polymorphisms and vertebral fractures in postmenopausal Japanese women . - pubmed
The C allele rs2470152 was significantly associated with increased risk of vertebral fractures ( P = 0.04 ) , whereas none of the CYP19 polymorphisms showed differences in sex steroid levels between subjects with and without fractures . - pubmed
Allelic variants of aromatase genes appear to interact to influence the risk of vertebral fractures in postmenopausal Japanese women . - pubmed
Platelet adenosine diphosphate ( ADP ) receptor antagonists ( ticlopidine , clopidogrel , prasugrel , and ticagrelor ) are a major advance in the treatment of atherothrombotic diseases , especially acute coronary syndromes ( ACS ) . - pubmed
Endothelin B receptor agonist , IRL-1620 , provides long - term neuroprotection in cerebral ischemia in rats . - pubmed
We have earlier shown that stimulation of endothelin B receptors by IRL-1620 provides significant neuroprotection at 24h following cerebral ischemia . - pubmed
This study was designed to determine the effect of IRL-1620 on neurological functions , infarct volume , oxidative stress , and endothelin receptors following permanent middle cerebral artery occlusion for 7 days . - pubmed
No change in expression of endothelin A receptor was observed 7 days after induction of cerebral ischemia in vehicle or IRL-1620 treated rats . - pubmed
Selective endothelin B receptor activation may prove to be a novel therapeutic target in the treatment of cerebral ischemia . - pubmed
Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer . - pubmed
Activation of the fibroblast growth factor receptor pathway is a common event in many cancer types . - pubmed
Here we review the role of fibroblast growth factor receptor signalling in breast cancer , from SNPs in FGFR2 that influence breast cancer risk and SNPs in FGFR4 that associate with breast cancer prognosis , and potential therapeutic targets such as receptor amplification and aberrant autocrine and paracrine ligand expression . - pubmed
Apolipoprotein E regulation of myeloid cell plasticity in atherosclerosis . - pubmed
PURPOSE OF REVIEW : Apolipoprotein ( apo ) E is a multifunctional protein that has long been recognized for its ability to safeguard against atherosclerosis . - pubmed
Among its pleiotropic roles known to suppress atherosclerosis , mechanisms by which apoE regulates cells of the immune system have remained elusive . - pubmed
Because atherosclerosis is a chronic inflammatory disease that remains on the rise , understanding in more detail how apoE controls immune cell activation and function is of much interest . - pubmed
By promoting cellular cholesterol efflux in a cell autonomous manner and through its ability to enhance HDL function in hyperlipidemic plasma , apoE is now known to suppress atherosclerosis by controlling myeloid cell proliferation , monocyte activation and their capacity to infiltrate the vascular wall . - pubmed
Lastly , the structural basis for apoE isoform - specific effects in macrophage dysfunction and atherosclerosis susceptibility is beginning to emerge . - pubmed
SUMMARY : Collectively , these findings introduce a new dimension to our understanding of how apoE links lipoprotein biology to monocyte and macrophage function in atherosclerosis susceptibility . - pubmed
STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease , Sjogren ' s syndrome . - pubmed
Here we report that mice with T - cell - targeted deletion of Stromal Interaction Molecule ( STIM ) 1 and STIM2 [ double - knockout ( DKO ) ] mice develop spontaneous and severe pSS - like autoimmune disease , displaying major hallmarks of the disease . - pubmed
Sjogren ' s syndrome - specific autoantibodies ( SSA / Ro and SSB / La ) were detected in the serum , and progressive salivary gland destruction and loss of fluid secretion were also seen . - pubmed
Importantly , we report that peripheral blood mononuclear cells as well as lymphocytic infiltrates in submandibular glands from patients with pSS demonstrated significant reductions in STIM1 and STIM2 proteins . - pubmed
Thus , deficiency of STIM1 and STIM2 proteins in T cells , and consequent defects in Ca ( 2 + ) signaling , are associated with salivary gland autoimmunopathy in DKO mice and pSS patients . - pubmed
These data reveal a previously unreported link between STIM1 and STIM2 proteins and pSS . - pubmed
Curcumin reduces cisplatin - induced neurotoxicity in NGF - differentiated PC12 cells . - pubmed
We also investigated whether curcumin affects cisplatin effectiveness by analyzing the modulation of p53 gene expression and its effect on cisplatin cytotoxicity in HepG2 tumor cells . - pubmed
Curcumin neither suppressed p53 mRNA transcription nor protected tumor cells against cisplatin cytotoxicity . - pubmed
The cardiotoxicity of DOX formulations was evaluated by serum creatine kinase MB ( CKMB ) activity in both animal groups before and after drug administration . - pubmed
Mutations in STT3A and STT3B cause two congenital disorders of glycosylation . - pubmed
We describe two unreported types of congenital disorders of glycosylation ( CDG ) which are caused by mutations in different isoforms of the catalytic subunit of the oligosaccharyltransferase ( OST ) . - pubmed
Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1 . - pubmed
Previous reports have associated GRHL2 with tumor progression . - pubmed
However , the biological role of GRHL2 in human colorectal cancer ( CRC ) has not been explored . - pubmed
We examined the expression of GRHL2 in 75 CRC samples , as well as the paired non - tumor tissues , by immunohistochemistry , qRT - PCR , and western blot analysis . - pubmed
We performed lentivirus - mediated shRNA transfection to knock down GRHL2 gene expression in HT29 and HCT116 CRC cells . - pubmed
Moreover , we transiently silenced ZEB1 expression in GRHL2 - knockdown CRC cells using specific shRNA , and then examined the effects on GRHL2 and E - cadherin expression , as well as cell proliferation . - pubmed
Herein , we demonstrated that enhanced GRHL2 expression was detected in CRC , and correlated with higher levels of Ki-67 staining , larger tumor size , and advanced clinical stage . - pubmed
Knocking down GRHL2 in HT29 and HCT116 CRC cells significantly inhibited cell proliferation by decreasing the number of cells in S phase and increasing that in the G 0 / G 1 phaseof the cell cycle . - pubmed
Collectively , our study has identified ZEB1 as a target of GRHL2 and suggested a reciprocal GRHL2 - ZEB1 repressive relationship , providing a novel mechanism through which proliferation may be modulated in CRC cells . - pubmed
KRT9 gene mutation as a reliable indicator in the prenatal molecular diagnosis of epidermolytic palmoplantar keratoderma . - pubmed
EPPK is generally caused by mutations of the KRT9 gene . - pubmed
More than 26 KRT9 gene mutations responsible for EPPK have been described ( Human Intermediate Filament Database , www.interfil.org ) , and many of these variants are located within the highly - conserved coil 1A region of the alpha - helical rod domain of keratin 9 . - pubmed
In the present study , we performed amniotic fluid - DNA - based prenatal testing for three at - risk pregnant EPPK women from three unrelated southern Chinese families who carried the KRT9 missense mutations p. Arg163Trp and p. Arg163Gln , and successfully helped two families to bear normal daughters . - pubmed
Toll - like receptors and cancer , particularly oral squamous cell carcinoma . - pubmed
Once activated , they initiate signaling pathways leading to the release of cytokines and chemokines , which recruit immune cells inducing further cytokine production , the production of angiogenic mediators and growth factors , all of which may influence tumor progression . - pubmed
This paper examines the actions of TLRs in carcinogenesis with particular emphasis on their role in oral squamous cell carcinoma . - pubmed
A great amount of factors are implicated in the pathogenesis of VVs , including changes in hydrostatic pressure , valvular incompetence , deep venous obstruction , ineffective function of calf muscle pump , biochemical and structural alterations of the vessel wall , extracellular matrix abnormalities , impaired balance between growth factors or cytokines , genetic alterations , and several other mechanisms . - pubmed
Amyloid - beta and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus . - pubmed
BACKGROUND : Amyloid - beta ( Abeta1 - 42 ) , total tau ( T - tau ) , and phosphorylated tau ( P - tau181 ) in the cerebrospinal fluid ( CSF ) are the most promising biomarkers of Alzheimer ' s disease ( AD ) . - pubmed
CONCLUSIONS : This is the first study to report ISF Abeta and tau levels in the human brain without significant brain injury . - pubmed
Peroxisome proliferator - activated receptor - gamma agonist inhibits the mammalian target of rapamycin signaling pathway and has a protective effect in a rat model of status epilepticus . - pubmed
Peroxisome proliferator - activated receptor gamma ( PPAR - gamma ) has a protective role in several neurological diseases . - pubmed
The present study investigated the effect of the PPAR - gamma agonist , pioglitazone , on the mammalian target of rapamycin ( mTOR ) signaling pathway in a rat model of pentylenetetrazol ( PTZ)-induced status epilepticus ( SE ) . - pubmed
First , the course of activation of the mTOR signaling pathway in PTZ - induced SE was examined to determine the time - point of peak activity , as reflected by phopshorylated ( p)-mTOR / mTOR and p - S6 / S6 ratios . - pubmed
The levels of the interleukin ( IL )- 1beta and IL-6 inflammatory cytokines were detected using ELISA , and neuronal loss was observed via Nissl staining . - pubmed
Compared with the vehicle treated - SE group , pretreatment with pioglitazone was associated with the loss of fewer neurons , lower levels of IL-1beta and IL-6 , and inhibition of the activation of the mTOR signaling pathway . - pubmed
Therefore , the mTOR signaling pathway was activated in the PTZ - induced SE rat model , and the PPAR - gamma agonist , pioglitazone , had a neuroprotective effect , by inhibiting activation of the mTOR pathway and preventing the increase in the levels of IL-1beta and IL-6 . - pubmed
Serum immunoglobulin G concentrations against hepatitis E were determined using the enzyme linked immunosorbent assay method . - pubmed
BACKGROUND : Adiponectin levels have been shown to be associated with colorectal cancer ( CRC ) . - pubmed
Therefore , we investigated the potential for a genetic association between T - cadherin and CRC risk . - pubmed
Study results revealed that rs3865188 in the 5 ' flanking region of the T - cadherin gene ( CDH13 ) was significantly associated with CRC ( p = 0.0474 ) . - pubmed
In addition , the interaction between CDH13 and the adiponectin gene ( APN ) for CRC risk was investigated using a logistic regression analysis . - pubmed
Furthermore , the plasma adiponectin level showed a correlation with the gene - gene interaction , and the group with the highest risk for CRC had the lowest adiponectin level ( median , 4.8 mug / mL for the TT / GG genotype vs.7.835 mug / mL for the AA / AA genotype , p = 0.0017 ) . - pubmed
CONCLUSIONS : The present study identified a new genetic factor for CRC risk and an interaction between CDH13 and APN in CRC risk . - pubmed
RESULTS : The results indicated that minocycline inhibited inflammation , decreased the expression of interleukin-1beta , tumor necrosis factor - alpha , and metalloproteinase - 9 , and squamous metaplasia features such as hyperproliferation and abnormal epidermal differentiation of conjunctival epithelium . - pubmed
Statistical analyses were performed using Plink and R. RESULTS : VKORC1 and CYP2C9 were the major genetic determinants of warfarin MWD and SMWD , with CYP4F2 having a smaller effect . - pubmed
Also , serum ferritin level was significantly higher in RAS patients ( p<0.008 ) . - pubmed
In the prenatal diagnosis of Gaucher disease ( GD ) , glucocerebrosidase ( GBA ) activity is measured with fetal cells , and gene analysis is performed when pathogenic mutations in GBA are identified in advance . - pubmed
Serum IgG and risk of exacerbations and hospitalizations in chronic obstructive pulmonary disease . - pubmed
Insulin therapy improves health outcomes in patients with CF . - pubmed
Family - based analysis of GGT1 and HNF1A gene polymorphisms in patients with polycystic ovary syndrome . - pubmed
Previous studies indicate that genes GGT1 and HNF1A may contribute to the abnormal glucose metabolism and altered lipid profile that are important clinical features of PCOS . - pubmed
In the current study , the correlation between polymorphisms in the GGT1 and HNF1A genes and PCOS was explored . - pubmed
A total of 310 family trios were studied and the transmission disequilibrium test ( TDT ) was used to assess the linkage between PCOS and three single - nucleotide polymorphisms ( SNP ) ( rs4820599 of GGT1 , rs7305618 and rs2393791 of HNF1A ) . - pubmed
None of the three SNP markers showed significant transmission disequilibrium in PCOS family trios ( rs4820599 : GGT1 gene , chi2 = 1.067 ; rs7305618 : HNF1A gene , chi2 = 0.013 ; rs2393791 : HNF1A gene , chi2 = 0.031 ) . - pubmed
In conclusion , no significant evidence supported a relationship between genes GGT1 and HNF1A and PCOS in the current family trios . - pubmed
Despite the very low quality of evidence , restoring normoxia in patients with hypoxia is recommended , and blood pressure lowering drugs and treating hyperglycaemia with insulin should be avoided . - pubmed
Our objective was to determine the rate of acromegaly comorbidities once hypersecretion of growth hormone is controlled . - pubmed
Our main outcome measures were the prevalence of major metabolic complications of acromegaly ( diabetes , hypertension , low - density lipoprotein cholesterol , triglycerides ) at diagnosis and last follow - up in comparison with French epidemiological data . - pubmed
We describe the performance of the VENTANA PD - L1 ( SP142 ) Assay in terms of specificity , sensitivity , and the ability to stain both tumor cells ( TC ) and tumor - infiltrating immune cells ( IC ) , in NSCLC and UC tissues . - pubmed
The reader precision , repeatability and intermediate precision , interlaboratory reproducibility , and the effectiveness of pathologist training on the assessment of PD - L1 staining on both TC and IC were evaluated . - pubmed
We detail the analytical validation of the VENTANA PD - L1 ( SP142 ) Assay for PD - L1 expression in NSCLC and UC tissues and show that the assay reliably evaluated staining on both TC and IC across multiple expression levels / clinical cut - offs . - pubmed
In addition , pathologists met the predefined training criteria ( & gt;=85.0 % overall percent agreement ) for the assessment of PD - L1 expression in NSCLC and UC tissues with an average overall percent agreement & gt;=95.0 % . - pubmed
Occludin protein expression in human cervical cancer and its association with patient 's clinical characteristics . - pubmed
Objective : The objective of the study was to investigate the expression of the tight junction protein occludin ( encoded by OCLN gene ) in human cervical cancer and its association with clinical features of patients . - pubmed
Immuno - histochemical assay was applied to examine the expression of occludin protein in 61 cervical cancer tissues and matched adjacent cancer normal tissues . - pubmed
Results : Occludin protein was mainly expressed in cell membranes and cytoplasm of both the cervical cancer cell and the normal cells . - pubmed
In cervical cancer tissues , the positive rate of occludin protein was 77.05 % ( 47/61 ) , whereas , in adjacent normal tissues of the cancer , the positive rate was 96.72 % ( 59/61 ) . - pubmed
Therefore , the positive rate of occludin in cervical cancer tissues was significantly lower than that of the adjacent cancer tissues ( P & lt ; 0.05 ) . - pubmed
Occludin protein expression level was not significantly correlated with the age ( P & gt ; 0.05 ) , tumor size ( P & gt ; 0.05 ) , International Federation of Gynecology and Obstetrics staging ( P & gt ; 0.05 ) , pathological grades ( P & gt ; 0.05 ) , and lymph node metastasis ( P & gt ; 0.05 ) of the patients . - pubmed
Conclusion : Occludin protein may contribute to the development of cervical cancer . - pubmed
Synthetic immunocortin in concentration ~ 10 - 9 M suppresses phagocytosis in peritoneal macrophages , ConA - dependent blast transformation of rat lymphocytes , exhibits ACTH - like neurotropic activity and was suggested as a potential drug for treatment of a multiple sclerosis ( MS ) . - pubmed
The attenuation of HIV-1 Tat - induced neurotoxicity by Salvianic acid A and Danshen granule . - pubmed
The neurotoxicity of HIV-1 Tat protein contributes significantly to the pathogenesis of HAND , and hence the attractive therapeutic strategies focusing on Tat - induced neurotoxicity are warranted . - pubmed
However , the protective effects of Salvianic acid A and Danshen granule on Tat - induced neurotoxicity remain unknown . - pubmed
In conclusion , this study demonstrated that Salvianic acid A and Danshen granule provides substantial neuroprotection against Tat - induced neurotoxicity , which may be new therapeutic agent in Tat induced HAND or neurodegenerative diseases . - pubmed
Intravenous tissue plasminogen activator for ischemic stroke in early pregnancy dosed by actual body weight . - pubmed
Methods : Here , we present a patient who received intravenous tissue plasminogen activator in the emergency department during her first trimester of pregnancy for the treatment of an acute ischemic stroke . - pubmed
Post tissue plasminogen activator imaging revealed recanalization of the vessel and the patient 's National Institutes of Health Stroke Scale was 0 . - pubmed
Conclusion : We present positive outcomes of a mother and fetus after receipt of intravenous tissue plasminogen activator using actual body weight during the first trimester of pregnancy for an acute ischemic stroke . - pubmed
Recently , damage to ER - mitochondria signaling involving disruption of the VAPB - PTPIP51 tethers has been linked to the pathogenic process in Parkinson ' s disease , fronto - temporal dementia ( FTD ) and related amyotrophic lateral sclerosis ( ALS ) . - pubmed
Loss of neuronal synaptic function is a key feature of Parkinson ' s disease and FTD / ALS but the roles that ER - mitochondria signaling and the VAPB - PTPIP51 tethers play in synaptic function are not known . - pubmed
Our results reveal a new role for the VAPB - PTPIP51 tethers in neurons and suggest that damage to ER - mitochondria signaling contributes to synaptic dysfunction in Parkinson ' s disease and FTD / ALS . - pubmed
Here , we demonstrate that a luciferase reporter assay , in combination with ChIP - qPCR , reliably separates pathogenic ZBTB24 missense variants in the context of immunodeficiency , centromeric instability , facial anomalies ( ICF ) syndrome from natural variants in healthy individuals and patients of other diseases . - pubmed
Application of our assay to two published ZBTB24 missense VUSs indicates that they are likely not to cause ICF2 syndrome . - pubmed
Furthermore , we show that rare gnomAD ZBTB24 missense variants in key residues of the C2H2 - ZF domain lead to a loss of function phenotype that resembles ICF2 , suggesting that these individuals are carriers of ICF syndrome . - pubmed
The loss of ARNT / HIF1beta in male pancreatic beta - cells is protective against high fat diet - induced diabetes . - pubmed
The transcription factor aryl hydrocarbon receptor nuclear translocator ( ARNT)/hypoxia - inducible factor ( HIF )- 1beta ( ARNT / HIF1beta ) plays a key role in maintaining beta - cell function and has been shown to be one of the most down regulated transcription factors in islets from type 2 diabetic patients . - pubmed
In order to gain a better understanding of the role of ARNT / HIF1beta in the development of diabetes , we placed control ( + /+/Cre ) and beta - cell specific ARNT / HIF1beta knockout ( fl / fl / Cre ) mice on a high fat ( HF ) diet . - pubmed
Overall , mice lacking ARNT / HIF1beta in beta - cells have altered lipid signalling in vivo and are resistant to a HF diets ability to induce diabetes . - pubmed
Long noncoding RNA GAS6 - AS2 sponges microRNA-493 , thereby enhancing the malignant characteristics of breast cancer cells via upregulation of FUT4 . - pubmed
Long noncoding RNA ( lncRNA ) GAS6 - AS2 serves as an oncogenic lncRNA in various types of human cancer . - pubmed
In this study , we attempted to examine the functions of GAS6 - AS2 in breast cancer ( BC ) and explore the potential mechanisms involved . - pubmed
Reverse - transcription quantitative PCR was carried out to determine GAS6 - AS2 expression in BC tissues and cell lines . - pubmed
Multiple functional experiments , including a Cell Counting Kit-8 assay , Transwell migration and invasion assays , and an in vivo nude - mouse xenograft experiment , were conducted to evaluate the effects of GAS6 - AS2 in BC cells . - pubmed
GAS6 - AS2 expression was high in BC tumors , manifesting a strong correlation with tumor size , lymph node metastasis , TNM stage , and shorter overall survival in patients with BC . - pubmed
A knockdown of GAS6 - AS2 restricted BC cell proliferation , migration , and invasion in vitro and retarded tumor growth in vivo . - pubmed
Either miR-493 inhibition or FUT4 upregulation abrogated the consequences of GAS6 - AS2 knockdown in BC cells . - pubmed
These results revealed that GAS6 - AS2 sponges miR-493 to enhance the malignant characteristics of BC in vitro and in vivo by increasing FUT4 expression . - pubmed
[ IgA vasculitis with massive hemorrhage from the jejunum after steroid administration ] . - pubmed
Administration of steroids or factor XIII is recommended for patients with severe abdominal pain refractory to conservative management . - pubmed
Our objective was to recruit patients with the OFD1 clinical phenotype without genetic confirmation , aiming to identify genetic variants in the OFD1 gene . - pubmed
CONCLUSIONS : These new genetic variants will add to the spectrum of known OFD1 mutations associated with the OFD1 disorder . - pubmed
Effect of Cinacalcet on the Redox Status of Albumin in Secondary Hyperparathyroidism Patients Receiving Hemodialysis . - pubmed
Cinacalcet is a calcimimetic that permits impaired endothelial functions to be recovered via inhibiting parathyroid hormone ( PTH ) production in SHPT patients . - pubmed
The purpose of this study was to examine the effect of cinacalcet on the redox state of human serum albumin ( HSA ) , a reliable marker for assessing endothelial oxidative damage in SHPT patients who were receiving hemodialysis . - pubmed
Moreover , the radical scavenging abilities of HSA that was isolated from SHPT patients were increased by cinacalcet , suggesting the recovery of the impaired vascular anti - oxidant ability . - pubmed
Interestingly , the oxidized albumin ratio in SHPT patients was significantly higher than that in hemodialysis patients . - pubmed
It therefore appears that PTH may induce oxidative stress in SHPT patients . - pubmed
The radiotherapy - induced tumors were five sarcomas , one of which was a well - differentiated angiosarcomatous vascular lesion with negative c - Myc ( benign lesion ) , and the remaining patient had basal cell carcinoma associated with radiotherapy . - pubmed
Recently , various studies have shown that angiotensin - converting enzyme 2 ( ACE2 ) acts as the " doorknob " that can be bound by the spike protein of severe acute respiratory syndrome coronavirus 2 ( SARS - CoV-2 ) , which conduces to its entrance to the host cells , and plays an important role in corona virus disease 2019 ( COVID-19 ) . - pubmed
6 - Hydroxyindole is an endogenous long - lasting OATP1B1 inhibitor elevated in renal failure patients . - pubmed
The hepatic uptake transporter organic anion transporting polypeptide ( OATP ) 1B1 is inhibited by some uremic toxins ; however , direct inhibition can only partially explain the delayed systemic elimination of substrate drugs in renal failure patients . - pubmed
Plasma concentration of 6 - hydroxyindole in renal failure patients increased as renal function decreased , but might be insufficient to exhibit potent OATP1B1 inhibition . - pubmed
In conclusion , 6 - hydroxyindole is an endogenous long - lasting OATP1B1 inhibitor with elevated plasma concentrations in renal failure patients . - pubmed
In conclusion , CTNNB1 mutations and a chr6 copy number loss are likely the causative mutations underlying the tumorigenesis of DT while the gene expression profiles may help to differentiate patients who would be good candidates for wait - and - see management and those who might benefit from additional systemic or radiation therapies . - pubmed
LncRNA PCAT1 Interacts with DKC1 to Regulate Proliferation , Invasion and Apoptosis in NSCLC Cells via the VEGF / AKT / Bcl2 / Caspase9 Pathway . - pubmed
The lncRNA prostate cancer associated transcript 1 ( PCAT1 ) has been involved in tumorigenesis of multiple malignant solid tumors , but it is largely unknown that what is the role of lncRNA - PCAT1 and how it functions in the progression of lung cancer . - pubmed
Herein , we observed that lncRNA PCAT1 expression was upregulated in both human NSCLC tissues and cell lines , which was determined by qualitative polymerase chain reaction analysis . - pubmed
The results showed that PCAT1 not only promoted NSCLC cell proliferation and invasion but also inhibited cell apoptosis . - pubmed
Then , RNA pull - down assays with biotinylated probes and transcripts both confirmed that PCAT1 directly bounds with DKC1 that could also promote NSCLC cell proliferation and invasion and inhibit cell apoptosis . - pubmed
Furthermore , PCAT1 and DKC1 activated the vascular endothelial growth factor ( VEGF)/protein kinase B ( AKT)/Bcl-2 / caspase9 pathway in NSCLC cells , and inhibition of epidermal growth factor receptor , AKT , or Bcl-2 could eliminate the effect of PCAT1 / DKC1 co - overexpression on NSCLC cell behaviors . - pubmed
In conclusion , lncRNA PCAT1 interacts with DKC1 to regulate proliferation , invasion , and apoptosis in NSCLC cells via the VEGF / AKT / Bcl-2 / caspase9 pathway . - pubmed
Use of AMH in the Differential Diagnosis of Anovulatory Disorders Including PCOS . - pubmed
Since the historical use of gonadotrophin and estradiol levels to define the different anovulatory disorders has shown some limitations , the use of other markers such as anti - mullerian hormone ( AMH ) has been proposed . - pubmed
This review addresses the role of AMH in the differential diagnosis of anovulatory disorders , especially focusing on its value in the prognostic characterization of their severity . - pubmed
Renal renin release in patients with essential arterial hypertension and with unilateral renal artery stenosis . - pubmed
Coexistence between CGRP and substance P ( SP ) occurs , SP being present in about one quarter of the CGRP - immunoreactive neurons and CGRP being localized in a little more than half of the SP - immunoreactive neurons . - pubmed
Expression of hepatic mRNAs for insulin - like growth factors - I and - II during the development of hypothyroid rats . - pubmed
In vivo effects of recombinant human interleukin 6 , alone or in combination with local irradiation , on tumor growth in Lewis lung carcinoma - bearing mice . - pubmed
Lewis lung carcinoma ( LLC )- bearing mice were used as a mouse model to evaluate effects of recombinant human ( rh ) interleukin ( IL ) 6 and local X - irradiation ( LR ) on the growth of primary tumors and lung metastases . - pubmed
with LLC tumor cells and then treated with rhIL-6 ( 100 ng / dose ) s.c . - pubmed
The size of the primary tumor and numbers of lung metastases were reduced by rhIL-6 . - pubmed
Prolonged survival time was observed only in tumor - bearing mice treated with rhIL-6 in combination with LR . - pubmed
These studies suggest that rhIL-6 may have therapeutic value in the treatment of certain malignancies , especially if used in combination with LR . - pubmed
Five tumors were studied with a polymerase chain - reaction assay designed to detect the E6 region of human papillomavirus types 16 and 18 . - pubmed
[ A high level of alkaline phosphatase in the blood serum is not a contraindication to embolization of the hepatic artery in malignant neoplasms of the liver ] . - pubmed
It was inferred that alkaline phosphatase activity is not indicative of extent of liver involvement by tumor . - pubmed
A study was made of the number of pulmonary endocrine cells , immunoreactive for gastrin - releasing peptide ( bombesin ) or calcitonin , in the terminal bronchioles of 39 cases of pulmonary vascular disease . - pubmed
Serum amylase , immunoreactive elastase ( IRE ) , carcinoembryonic antigen ( CEA ) , and carbohydrate antigen ( CA 19 - 9 ) were measured in 40 patients with pancreatic cancer . - pubmed
In pancreatic cancer , elevated values were observed for amylase in 30 % of the patients , for IRE in 70 % , for CEA in 28 % , and for CA 19 - 9 in 68 % . - pubmed
Elevated serum IRE was observed more frequently in head cancer and resectable cancer , whereas elevation in CA 19 - 9 occurred more often in body - tail cancer and unresectable cancer . - pubmed
Elevation of serum IRE tends to occur at earlier stages of pancreatic cancer . - pubmed
Renal interaction between sympathetic activity and ANP in rats with chronic ischaemic heart failure . - pubmed
The diuretic and natriuretic effects of r - alpha - ANP ( 99 - 126 ) were investigated in rats with chronic ischaemic heart failure ( IHF ) produced by left coronary artery ligation . - pubmed
Immunoglobulin isotypes of anti - HBc and anti - HBe and hepatitis B virus ( HBV ) DNA elimination in acute hepatitis B. - pubmed
Antibodies to hepatitis B core antigen ( anti - HBc ) and e antigen ( anti - HBe ) were assayed in 46 sera from ten patients with acute hepatitis B utilizing immunoglobulin class- and subclass - specific enzyme immunoassays ( EIAs ) . - pubmed
Co - incident N and K ras gene mutations in a case of AML , restricted to differing cell lineages . - pubmed
Peripheral blood from a patient with acute myeloid leukaemia ( AML ) of M5 FAB classification , was shown to have mutations to both the N and K ras genes . - pubmed
The K - ras mutation , however , was present in all fractions , suggesting it had occurred in a multi - potential stem cell representing an earlier stage in the generation of the leukaemia , or possibly an incidental background phenomenon . - pubmed
Autoantibody from a patient with systemic lupus erythematosus was used to label PCNA in cell suspensions after the cells had been fixed and permeabilized . - pubmed
Peritonitis incidence and in vitro bacterial opsonization has been shown to depend on IgG concentrations in the dialysate and on the ability of macrophages to produce fibronectin . - pubmed
In some CAPD patients a disturbance in lymphokine and monokine release may be responsible for the reduced ability of their macrophages to kill bacteria . - pubmed
With GVHD directed to class I H-2 differences , pretreating LN cells with anti - Lyt-2 MAb prevented mortality , whereas MAb specific for Ly-1 or L3T4 cell surface determinants caused severe mortality . - pubmed
These data imply that lethal GVHD directed to class I H-2 differences is mediated by L3T4- , Lyt-2 + cells ; this subset of T cells was shown previously to control GVHD directed to multiple minor histocompatibility antigens , i.e. - pubmed
With whole H-2 differences , GVHD appeared to be controlled largely but not exclusively by L3T4 + , Lyt-2 - T cells . - pubmed
With class II incompatibilities , depleting donor cells of L3T4 + T cells , either by pretreatment with anti - L3T4 MAb + C or by fluorescence activated cell sorter selection , greatly reduced but did not completely abolish GVHD . - pubmed
The prognostic application of HL - A and ABO typing in placental choriocarcinoma . - pubmed
A common link between the induction of leukemia by ( i ) fractionated doses of x - irradiation and ( ii ) radiation leukemia virus in mice may be established by the observation that the segment of chromosome 2 between the loci for the minor histocompatibility antigen H-30 and color coat agouti ( H-30 - A ) includes distinct loci involved in susceptibility to leukemogenesis induced by factors i and ii . - pubmed
The concept of atypical depression is reviewed and data comparing the clinical effects of monoamine oxidase inhibitors and tricyclic antidepressants are presented . - pubmed
Monoamine oxidase inhibitors are indicated for treatment of syndromes of panic and generalized anxiety with or without supervening atypical depression . - pubmed
We investigated the hemodynamics of the greater and lesser circulation in 35 patients with primary hypertension , as well as the effects of calcium - channel blockade , to test whether a common factor may account for the excessive vascular resistance in the two circuits and whether intracellular calcium concentration ( [ Ca++]i ) may be involved . - pubmed
Oestrogen receptors and metabolism of oestrone sulphate in human mammary carcinoma . - pubmed
Islet amyloid polypeptide and its N - terminal and C - terminal flanking peptides ' immunoreactivity in islet amyloid of diabetic patients . - pubmed
In three non - diabetic subjects , pancreatic islet cells were immunoreactive to anti - IAPP8 - 17 and anti - N - terminal and C - terminal flanking peptide antibodies and the reactivity was enhanced with formic acid pretreatment . - pubmed
In six type 2 diabetic subjects and a subject with type A insulin resistance , islet amyloid deposits were reactive to anti - IAPP8 - 17 antibody , but not to anti - N - terminal and C - terminal flanking peptide antibodies . - pubmed
Osteopontin expression is increased in the heritable cardiomyopathy of Syrian hamsters . - pubmed
BACKGROUND : Osteopontin , a noncollagenous matrix protein , is transiently expressed in the heart after experimental cardiac injury , but its expression in states of continuing cardiac remodeling is unknown . - pubmed
We evaluated osteopontin expression in the heritable cardiomyopathy of the Syrian hamster . - pubmed
Osteopontin mRNA was 12 - fold greater in cardiomyopathic hearts compared with normal controls ( 1.76 + /- 0.31 versus 0.14 + /- 0.04 arbitrary units normalized to GAPDH , mean + /- SEM , P & lt ; .05 ) . - pubmed
Osteopontin mRNA above background levels was not detected in sections from noncardiomyopathic hamster hearts but was readily detected in sections from cardiomyopathic hamsters , in which it originated in cells morphologically consistent with tissue macrophages . - pubmed
CONCLUSIONS : In the hamster , osteopontin is expressed in heritably cardiomyopathic hearts under conditions of chronic injury and repair , and the source of ostopontin message appears to be issue macrophage - like cells in foci of inflammation . - pubmed
This model could be used to evaluate the biological role of osteopontin in myocardial inflammation and remodeling . - pubmed
Growth stimulation of ferritin of human leukemia cells in vitro . - pubmed
Ferritin has been reported to inhibit the growth of some leukemia cells in serum - supplemented culture . - pubmed
Recently we have found that ferritin stimulates the proliferation of human acute myeloblastic leukemia cells HL-60 and erythroleukemia cells K-562 - T1 in serum - free medium . - pubmed
In this study , we examined the effect of ferritin against 14 human leukemia cell lines using human heart ferritin in serum - depleted culture medium . - pubmed
These results suggest that ferritin has dual functions ; it promotes the growth of leukemia cells with low concentrations of FCS , but suppresses their growth with high concentrations of FCS . - pubmed
Antibodies against CD4 + lymphocytes are frequently detectable in HIV - infected patients . - pubmed
The experiments revealed that 60 % of HIV - infected patients harbored anti - CD4 cell antibodies in their plasma . - pubmed
There was a significant reduction in serum insulin levels and glucose clearance rates without overt diabetes for 30 Gy and 35 Gy ( p & lt ; 0.05 ) . - pubmed
Nucleotide sequences of the central portion of gp120 , including the third hypervariable ( V3 ) loop , were obtained from lymphocytes cocultivated with SupT1 cells from 29 AIDS patients in Bangui , Central African Republic . - pubmed
Glutathione S - transferase in human esophageal carcinoma . - pubmed
The expression of human glutathione S - transferase - pi ( GST - pi ) in esophageal squamous cell carcinoma and in corresponding morphologically normal mucosa from 17 patients was examined by Northern blots , in situ hybridization and immunohistochemistry . - pubmed
Relative GST - pi expression ( tumor / mucosa ) ranged from 0.31 to 1.52 ( 0.821 + /- 0.40 : mean + /- SD ) , and only 6 out of 17 cases demonstrated increased GST - pi transcripts in tumor tissue over normal tissue . - pubmed
No significant correlation was observed between the amount or pattern of GST - pi expression by carcinomas and the clinicopathological findings in the cases . - pubmed
The marked expression of GST - pi by non - pathologic mucosa obtained from the patients with esophageal carcinoma suggests that GST - pi may be a marker of increased carcinogen exposure , but not necessarily a marker of developed human esophageal cancer . - pubmed
Increased plasma - soluble fibrin monomer levels in patients with disseminated intravascular coagulation . - pubmed
Plasma - soluble fibrin monomer ( SFM ) level in patients with disseminated intravascular coagulation ( DIC ) was significantly higher than the level in patients with pre - DIC or in non - DIC patients , and the level in patients with pre - DIC was significantly higher than that in non - DIC patients . - pubmed
There was no significant difference in plasma SFM levels among various diseases underlying DIC . - pubmed
Plasma SFM level in patients with good outcome was significantly decreased after treatment for DIC . - pubmed
Receiver operating characteristic analysis suggests that plasma SFM level could be the most useful marker for the diagnosis of both DIC and pre - DIC . - pubmed
Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington ' s disease . - pubmed
The delivery of ciliary neurotrophic factor ( CNTF ) to the central nervous system has recently been proposed as a potential means of halting or slowing the neural degeneration associated with Huntington ' s disease ( HD ) . - pubmed
The following set of experiments examined , in detail , the ability of human CNTF ( hCNTF ) to prevent the onset of behavioral dysfunction in a rodent model of HD . - pubmed
These results support the concepts that implants of polymer - encapsulated hCNTF - releasing cells can be used to protect striatal neurons from excitotoxic damage , produce extensive behavioral protection as a result of that neuronal sparing , and that this strategy may ultimately prove relevant for the treatment of HD . - pubmed
CONCLUSIONS : In non - metastatic osteosarcoma of the extremity , chemotherapy - induced tumor necrosis , the baseline LDH serum value and the use of HDMTX are significant predictive factors for DFS . - pubmed
Hypochromic red cells and reticulocyte haemglobin content as markers of iron - deficient erythropoiesis in patients undergoing chronic haemodialysis . - pubmed
BACKGROUND : In patients on chronic haemodialysis , because of a non - specific increase in serum ferritin , iron deficiency may be overlooked leading to failure of erythropoietin treatment . - pubmed
Transferrin saturation was also measured in a subset of 25 patients ; iron deficiency was defined as a transferrin saturation & lt ; 15 % . - pubmed
RESULTS : The diagnostic sensitivity and specificity of a reticulocyte haemoglobin content & lt ; 26 pg in detecting iron deficiency were 100 % and 73 % respectively , compared with 91 % and 54 % for a percentage of hypochromic red cells & gt ; 2.5 . - pubmed
CONCLUSIONS : The reticulocyte haemglobin content is superior to the percentage of hypochromic red cells in detecting iron deficiency in haemodialysis patients . - pubmed
Unusual features of this case of gliomatosis cerebri include involvement of the entire central neuraxis , correlation with pre - mortem lumbar puncture cytology , and a markedly elevated Ki-67 labeling index . - pubmed
The Brn-3a transcription factor plays a critical role in regulating human papilloma virus gene expression and determining the growth characteristics of cervical cancer cells . - pubmed
Moreover , Brn-3a is overexpressed approximately 300 - fold in cervical biopsies from women with cervical intra - epithelial neoplasia type 3 ( CIN3 ) compared with normal cervical material . - pubmed
To test the role of Brn-3a in cervical neoplasia we have manipulated its expression in cervical carcinoma - derived cell lines with or without endogenous HPV genes . - pubmed
MATERIALS AND METHODS : Human urothelial cells cultured from normal bladder specimens underwent immunohistochemical staining and cellular extracts were prepared for Electrophoretic Mobility Shift Assays ( EMSA ) , Western blot analyses , RNA isolation and Northern Blot analyses before and after stimulation with TNF - alpha , LPS , and dsRNA . - pubmed
Systemic hypothermia following spinal cord compression injury in the rat : axonal changes studied by beta - APP , ubiquitin , and PGP 9.5 immunohistochemistry . - pubmed
OBJECTIVES : The present study addresses the question as to whether systemic hypothermia has similar protective qualities following severe spinal cord compression trauma using beta - APP- , ubiquitin- , and PGP-9.5 - immunohistochemistry combined with the ABC complex method as markers to identify axonal changes . - pubmed
Hemodynamic abnormalities in the left atrial appendage in patients with paroxysmal atrial fibrillation , with special reference to albumin - contrast echocardiographic aspects . - pubmed
METHODS AND RESULTS : Transesophageal echocardiography with intravenous albumin - microspheres ( Albunex , 0.2 ml / kg ) was performed in 100 consecutive patients ( 44 patients in sinus rhythm without previous paroxysmal atrial fibrillation : 13 patients in sinus rhythm who had had previous episodes of paroxysmal atrial fibrillation ; and 43 patients with sustained atrial fibrillation ) . - pubmed
Using a refinement of a previously reported cell fusion complementation assay , the previously assigned Ddb+ xeroderma pigmentosum E strains , XP89TO , XP43TO , and XP24KO , with various phenotypes in DNA repair markers , were reassigned to xeroderma pigmentosum group F , xeroderma pigmentosum variant , and ultraviolet - sensitive syndrome , respectively . - pubmed
The Ddb - xeroderma pigmentosum E strains , XP82TO , and GM02415B , which showed almost normal cellular phenotypes in DNA repair markers , however , remained assigned to xeroderma pigmentosum group E. With the exception of the Ddb+ strain XP89TO , which demonstrated defective nucleotide excision repair , both Ddb- and Ddb+ xeroderma pigmentosum E cells exhibited the same levels of variation in unscheduled DNA synthesis that were seen in normal control cells . - pubmed
By genome DNA sequencing , the two Ddb - xeroderma pigmentosum E strains were shown to have mutations in the DDB2 gene , confirming previous reports for XP82TO and GM02415B , and validating the classification of both cells . - pubmed
As only the Ddb- strains investigated remain classified in the xeroderma pigmentosum E complementation group , it is feasible that only Ddb- cells are xeroderma pigmentosum E and that mutations in the DDB2 gene are solely responsible for the xeroderma pigmentosum E group . - pubmed
OBJECTIVE : In the present study , the frequency of ANT and its associations with collagen vascular and spinal disease have been investigated . - pubmed
Although patients produce antibody exuberantly , the immunopathogenesis involves cellular immunity -- notably , CD8(+ ) cytotoxic lymphocytes , multinucleate giant cell granulomas , and ultimately interstitial fibrosis . - pubmed
In typical cases , the history of a known exposure and the presence of a characteristic interstitial lung disease with serologic confirmation of IgG antibody to the offending antigen suffice for diagnosis . - pubmed
In vitro study of IL-8 and goblet cells : possible role of IL-8 in the aetiology of otitis media with effusion . - pubmed
These results suggest that : ( i ) goblet cells are target cells for the pro - inflammatory cytokines IL-1beta , TNF - alpha and IL-8 and can contribute to the pathogenesis of OME by increasing both the concentration of IL-8 and the secretion of mucin ; and ( ii ) IL-8 stimulates prolonged mucin secretion from goblet cells and may be involved in the maintenance of the disease in the chronic stage . - pubmed
alpha - and beta - secretase : profound changes in Alzheimer ' s disease . - pubmed
The amyloid plaque , a neuropathological hallmark of Alzheimer ' s disease , is produced by the deposition of beta - amyloid ( Abeta ) peptide , which is cleaved from Amyloid Precursor Protein ( APP ) by the enzyme beta - secretase . - pubmed
Here , we describe a decrease in alpha - secretase ( 81 % of normal ) and a large increase in beta - secretase activity ( 185 % ) in sporadic Alzheimer ' s disease temporal cortex . - pubmed
Since alpha - secretase is present principally in neurons known to be vulnerable in Alzheimer ' s disease , and there is known competition between alpha- and beta - secretase for the substrate APP , it is significant that the majority of Alzheimer samples tested here were low in alpha - secretase . - pubmed
Eighty percent of Alzheimer brains examined had an increase in beta - secretase , a decrease in alpha - secretase , or both ; which may account for the means by which the majority of people develop Alzheimer ' s disease . - pubmed
Blood glucose monitoring is recommended : to evaluate the glycemic response to the effect of insulin ; to confirm hypoglycemia ; to prevent hyperglycemia in case of disease ; in case of physical exercise . - pubmed
Flavopiridol , a cyclin - dependent kinase ( cdk ) inhibitor , can cause cell cycle arrest , induce apoptosis in cancer cells , and inhibit tumor cell growth in vivo . - pubmed
The objective of this study was to investigate the use of folate - targeted liposomes for the delivery of encapsulated oligonucleotides to folate receptor ( FR)-positive tumor cells in vitro and in vivo . - pubmed
We conclude from these results that folate liposomes can effectively deliver oligonucleotides into folate receptor - bearing cells in vitro , but additional barriers exist in vivo that prevent or decrease effective tumor uptake and retention . - pubmed
Effects of immunoregulatory cytokines ( interferon - gamma [ IFN - gamma ] and interleukin-10 [ IL-10 ] ) and HSV antigens on B7 - 1 ( CD80 ) and B7 - 2 ( CD86 ) expression on monocytes during HSV-2 infection were investigated using flow cytometry . - pubmed
Our results demonstrate that HSV-2 infection effects the expression of B7 isoforms ( B7 - 1 and B7 - 2 ) on monocytes in two ways , with opposing outcomes . - pubmed
Tuberculin - histoplasmin conversion rates in Kansas City as an indication of the prevalence of infection - preliminary report . - pubmed
We have shown that in several chronic inflammatory diseases like chronic inflammatory bowl disease , peritonitis and rheumatoid arthritis , transsignaling via the soluble IL-6R complexed to IL-6 is a crucial point in the transition from the acute to the chronic state of the disease . - pubmed
Expression of MMP-2 , MMP-7 , MMP-9 , MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas . - pubmed
The members of the matrix metalloproteinase family ( MMP ) have the ability to degrade macromolecules of the extracellular matrix and are responsible for tumor invasion and infiltration , limiting the effectiveness of the neurosurgical resection of brain tumors . - pubmed
To determine the pattern of MMP expression in astrocytic and oligodendroglial tumors , sections of astrocytic and oligodendroglial differentiated glioblastomas ( WHO grade IV ) , as well as of anaplastic oligodendrogliomas ( WHO grade III ) and anaplastic gemistocytic astrocytomas ( WHO grade III ) were immunostained for MMP-2 , MMP-7 , MMP-9 , MMP-10 and MMP-11 . - pubmed
MMP-7 , MMP-10 and MMP-11 were strongly expressed by neoplastic gemistocytic astrocytes while oligodendrocytic tumor regions showed only a low immunoreaction . - pubmed
These data indicated that MMP-7 , MMP-10 and MMP-11 contribute to the worse prognosis of astrocytic tumors when compared to oligodendrogliomas , while MMP-2 and MMP-9 might play an important role in neo - angiogenesis and tumor vascularization . - pubmed
Because cytomegaly occurs between 24 and 96 hpi , access to this larger LIP could be expected to facilitate enlargement to approximately 375 % of the initial cell size . - pubmed
The ability of Fe chelation by 100 microM SIH to limit enlargement to approximately 180 % confirms that the LIP plays a major role in cytomegaly . - pubmed
The serum HBV - DNA , HBeAg / anti - HBe , hepatic chemistry and the hepatic fibrosis markers were studied . - pubmed
CONCLUSION : These results suggested that lamivudine ( 100mg / d ) could suppress HBV - DNA replication , promote ALT normalization , accelerate HBeAg / anti - HBe seroconversion , improve the liver pathological changes , slow down the development of liver fibrosis - pubmed
Gemtuzumab ozogamicin ( GO ) , an anti - CD33 monoclonal antibody conjugated to calicheamicin , is effective as single agent in the treatment of poor risk acute myeloid leukaemia ( AML ) patients . - pubmed
The purpose of this study was to compare time- and dose - dependent cellular responses to Tpt in terms of alterations in the amount and stability of topo 1 in lung adenocarcinoma ( A-549 ) , ovarian adenocarcinoma ( CaOv-3 ) , colorectal adenocarcinoma ( HT-29 ) and breast adenocarcinoma ( MCF-7 ) cell lines . - pubmed
CONCLUSIONS : Our results suggested that disturbance of the balance of the AT1 and AT2 receptors could trigger pregnancy induced hypertension . - pubmed
Short - term intensive insulin therapy in newly diagnosed type 2 diabetes : response to Ryan , Imes , and Wallace . - pubmed
Noninvasive detection of prostate cancer by quantitative analysis of telomerase activity . - pubmed
The purpose of this study was to clarify whether quantitative analysis of telomerase activity in exfoliated cells in urine could serve as a reliable molecular marker of prostate malignancy . - pubmed
RESULTS : We report now that all prostate cancer patients revealed high levels of telomerase activity thereby showing 100 % of the assay sensitivity . - pubmed
In contrast , the majority of patients with clinically confirmed benign prostatic hyperplasia ( BPH ) did not express any telomerase activity ( 70 % of all BPH patients ) , most likely presenting cancer - free cases , or expressed low levels of activity ( 18 % ) . - pubmed
However , about 12 % of BPH patients revealed high levels of telomerase activity that potentially can reflect hidden prostate cancer . - pubmed
CONCLUSIONS : We suggest that the quantitative analysis of telomerase activity can be useful for the selection of prostate cancer and cancer - free cases . - pubmed
Indeed , there is growing evidence that the gonadotropin , luteinizing hormone , which regulates serum estrogen and testosterone concentrations , could be an important causative factor in the development of Alzheimer ' s disease . - pubmed
This review provides information supporting the " gonadotropin hypothesis , " puts forth a novel mechanism of how changes in serum luteinizing hormone concentrations could contribute to the pathogenesis of Alzheimer ' s disease , and discusses potential therapeutic anti - gonadotropin compounds . - pubmed
In situ gene expression and localization of metalloproteinases MMP1 , MMP2 , MMP3 , MMP9 , and their inhibitors TIMP1 and TIMP2 in human renal cell carcinoma . - pubmed
Alterations of MMP and TIMP expressions have been found in several malignant tumour entities . - pubmed
In this study the expression pattern of MMP1 , MMP2 , MMP3 , MMP9 , and their inhibitors TIMP1 , and TIMP2 were investigated at mRNA and protein levels in human renal cell carcinoma ( RCC ) . - pubmed
MMP1 - antigen was strongly expressed in tumour epithelium with moderate stroma expression in one case . - pubmed
The gelatinases MMP2 and MMP9 showed moderate to strong signals in tumour epithelial cells at the mRNA and protein level , while the expression in tumour stroma was moderate . - pubmed
MMP3 - mRNA and -antigen were expressed moderately to strong in tumour epithelium and focally in stroma cells . - pubmed
mRNA or TIMP1- and TIMP2 - mRNA and -antigen were also predominantly expressed in tumour epithelium ; only few samples showed positive expression in stroma cells . - pubmed
We found a pronounced expression for the gelatinases MMP2 and MMP9 and for MMP3 in RCC at the mRNA and protein level . - pubmed
The expression of TIMP1 and TIMP2 appears also to be relevant in RCC . - pubmed
Neonatal lupus is linked to the presence of anti - Ro / SS - A and anti - La / SS - B antibodies in the mother , although other factors probably of fetal origin are important . - pubmed
Haptoglobin is a positive acute - phase protein with a valuable role as a marker of inflammation in both human and veterinary medicine . - pubmed
No significant differences were produced by anticoagulants , lipaemia and bilirubinaemia , although haemolysis significantly decreased haptoglobin . - pubmed
A significant increase of haptoglobin concentration was detected in inflammatory conditions such as pyometra and leishmaniasis , in neoplastic conditions , and after glucocorticoid administration . - pubmed
In order to exclude a familiar PAH , the analysis of the bone morphogenetic protein receptor 2 gene was carried out , but no mutations were found . - pubmed
Several findings supported the hypothesis that Aer has a four - helix HAMP structure : ( i ) cross - linking independently identified the same residues at the dimer interface that were predicted by the model , ( ii ) the rate of cross - linking for residue pairs was inversely proportional to the beta - carbon distances measured on the model , and ( iii ) clockwise lesions that were not contiguous in the linear Aer sequence were clustered in one region in the folded HAMP model , defining a potential site of PAS - HAMP interaction during signaling . - pubmed
Trp63 mutations are involved in the pathogenesis of several human diseases , phenotypically characterized by ectodermal dysplasia . - pubmed
Periodic acid - Schif staining and immunohistochemical staining of CD34 were conducted to explore if VM exists in those Rb specimens . - pubmed
HIF-1alpha and VEGF expressions in Rb with VM were significantly greater than those in Rb without VM ( P = 0.001 ) . - pubmed
CONCLUSIONS : VM exists in Rb . - pubmed
Highly differentiated Rb exhibits more VM than that in less differentiated Rb . - pubmed
Expression of HIF-1alpha and VEGF is greater in Rb with VM , indicating that these factors may stimulate the occurrence of VM . - pubmed
CONCLUSIONS : Our study confirmed a close association between preoperative glucose control indicated by HbA ( 1c ) levels & lt;7 % and a decreased risk of postoperative infectious complications . - pubmed
IFN - gamma - receptor signaling ameliorates transplant vasculopathy through attenuation of CD8 + T - cell - mediated injury of vascular endothelial cells . - pubmed
However , MCMV - LacZ infection of recipients of ifngr(-/- ) Tie2 - LacZ hearts led to massive activation of beta - gal - specific CD8 T cells , and led to development of fulminant TV . - pubmed
Further analyses revealed that the strong systemic IFN - gamma " storm " associated with MCMV infection induced upregulation of programmed death-1 ligand 1 ( PD - L1 ) on EC , and subsequent attenuation of programmed death-1 ( PD-1)-expressing EC - specific CD8(+ ) T cells . - pubmed
Thus , IFNGR signaling in ECs activates a potent peripheral negative feedback circuit that protects vascularized grafts from occlusive TV . - pubmed
These patients were predominantly male ( 92.9 % vs 80.3 % , P & lt ; 0.001 ) , more likely to smoke ( 75.8 % vs 47.2 % , P & lt ; 0.001 ) , obese ( 48.2 % vs 27.9 % , P = 0.002 ) , have higher triglyceride levels ( 176.9 + /- 153.8 mg / dL vs 140.7 + /- 112.7 mg / dL , P = 0.005 ) , and lower high - density lipoprotein cholesterol ( 37.1 + /- 7.9 mg / dL vs 42.8 + /- 14.3 mg / dL , P = 0.005 ) than older patients . - pubmed
The recombinant outer membrane protein OprF / I has been demonstrated in previous studies to protect against Pseudomonas aeruginosa infection through a mechanism of enhanced antibody - mediated opsonophagocytosis . - pubmed
aeruginosa binding to IFN - gamma , suggesting an alternative mechanism by which the OprF / I vaccine confers protection against P. - pubmed
Multiple regression analysis revealed that the factors contributing to the elevation of ABR threshold were congenital diaphragmatic hernia , severe respiratory disease , and a high C - reactive protein ( CRP ) level . - pubmed
Factors significantly related to an elevation of ABR threshold were a history of congenital diaphragmatic hernia , severe respiratory disease , and elevation of CRP . - pubmed
We present a case of metastatic CDC that responded favorably to a multiple tyrosine kinase inhibitor , sunitinib , achieving a partial response in both lung and skeletal metastases . - pubmed
Considering these findings , it would be worthwhile prospectively investigating the role of multiple tyrosine kinase inhibitors , particularly sunitinib , in the management of metastatic CDC . - pubmed
[ The expression of CEACAM-1 and CXCL-14 in infantile hemangioma ] . - pubmed
OBJECTIVE : To examine the expression of CEACAM - land CXCL-14 in the different stages of infantile hemangioma and to explore the role of CEACAM-1 and CXCL-14 in the occurrence and development of infantile hemangioma . - pubmed
METHODS : The expression of CEACAM-1 and CXCL-14 was detected by immunohistochemical technique and Western Blot in cases of proliferating hemangiomas , involuting hemangiomas , involuted hemangiomas . - pubmed
RESULTS : The expression of CEACAM-1 in early stage of proliferating hemangiomas was weak or negative , while it was strong in involuting hemangiomas and positive in the involuted stage . - pubmed
The expression of CXCL-14 was weak or negative in stage of proliferating hemangiomas , positive in involuting hemangiomas and strong in the involuted stage . - pubmed
CONCLUSIONS : CEACAM-1 and CXCL-14 are involved in the occurrence and development of infantile hemangioma . - pubmed
We planned this case - control study to evaluate the relationship between hypogonadism , as defined by the sexual hormone profile ( FSH , LH , testosterone ( T ) and prolactin ) and ED , as assessed by means of an internationally validated self - administered questionnaire ( IIEF ) . - pubmed
DM1 patients had significantly increased mean levels of both gonadotropins ( FSH and LH ) ( p < 0.0001 ) and a reduced mean level of T ( p < 0.0001 ) when compared to controls . - pubmed
Twelve patients were eugonadic ( normal LH , T , and FSH ) , while 18 displayed hormonal evidence of hypogonadism , characterized by tubular failure ( increased FSH ) in all the subjects and associated with interstitial failure in 14 subjects : seven with primary hypogonadism ( increased LH and reduced T ) and seven with compensated hypogonadism ( increased LH and normal T ) . - pubmed
In general , patients with recent onset RA have earlier clinical improvement when treated with initial combination therapy with prednisone or a tumor necrosis factor inhibitor than when treated with initial monotherapy . - pubmed
Rac1 is necessary for their transition from G1 to S phase , at least in part by regulating cyclin D levels and retinoblastoma protein phosphorylation . - pubmed
Purine / Pyrimidine nucleotides ratio ( OD 260 : OD 280 ) was also measured RESULTS : P5'N-1 deficient patients showed reduction in P5'N-1 activity ( Mean + - SD ; 4.06 + - 0.66 using an ELISA reader & amp ; 6.25 + - 1.37 using a spectrophotometer ) as compared to the normal control group ( ELISA reader : 13.24 + - 3.42 & amp ; Spectrophotometer : 18.25 + - 3.20 ) . - pubmed
[ Generation of antitumor response against hepatocellular carcinoma by in vitro transduction of dendritic cells with adeno - associated virus expressing alpha - fetoprotein ] . - pubmed
OBJECTIVE : To investigate the generation of antitumor response against hepatocellular carcinoma by in vitro transduction of dendritic cells ( DC ) with recombinant adeno - associated virus expressing alpha - fetoprotein ( rAAV - AFP ) . - pubmed
19.84 % of CD4(+)T cells and 18.65 % of CD8(+)T cells activated by AAV - AFP + DC produced IFN - gamma but not IL-4 and showed distinct killing activities against AFP positive hepatocellular carcinoma cell lines HepG2 ( 56.45 % ) and BEL7402 ( 78.84 % ) . - pubmed
CONCLUSION : AAV - AFP + DC can elicit distinct antitumor responses against AFP positive hepatocellular carcinoma cell lines so as to provide a basis for further researches on the clinical application of AAV - AFP + DC in the treatment of hepatocellular carcinoma . - pubmed
Anaemia during pregnancy : impact on birth outcome and infant haemoglobin level during the first 18 months of life . - pubmed
To determine the effect of maternal anaemia on pregnancy outcome and describe its impact on infant haemoglobin level in the first 18 months of life , we conducted a prospective study of 617 pregnant women and their children in Benin . - pubmed
There was no association between an infant 's haemoglobin level until 18 months and maternal anaemia . - pubmed
However , malaria attacks during follow - up , male gender and sickle cell trait were all associated with a lower infant haemoglobin level until 18 months , whereas good infant feeding practices and a polygamous family were positively associated with a higher haemoglobin level during the first 18 months of life . - pubmed
Analysis of serum total IgE , specific IgE and eosinophils in children with acute and chronic urticaria . - pubmed
BACKGROUND / PURPOSE : Increased IgE and eosinophil levels are frequently observed in cutaneous inflammation and are thought to provoke the occurrence of urticaria . - pubmed
The aim of this study was to compare serum total IgE levels , specific IgE sensitization rates and eosinophil percentages between acute and chronic urticaria in children . - pubmed
Serum levels of total IgE , prevalence of sensitization to food and aeroallergens and blood eosinophil percentages were compared by the disease duration of urticaria . - pubmed
RESULTS : There were no statistical differences in total IgE production , positive sensitization to specific allergens and eosinophil percentages between the patients with acute and chronic urticaria . - pubmed
CONCLUSION : Boys potentially have a higher serum IgE expression than girls children with urticaria . - pubmed
IgE levels and eosinophil percentages are not good indicators for a prolonged course of urticaria . - pubmed
Plasma fatty acid - binding protein 4 , nonesterified fatty acids , and incident diabetes in older adults . - pubmed
OBJECTIVE : To examine the relation of fatty acid - binding protein ( FABP ) 4 and nonesterified fatty acids ( NEFAs ) to diabetes in older adults . - pubmed
For each SD increase in log FABP4 , hazard ratios ( HRs ) for diabetes were 1.35 ( 95 % CI 1.10 - 1.65 ) for women and 1.45 ( 1.13 - 1.85 ) for men controlling for age , race , education , physical activity , cystatin C , alcohol intake , smoking , self - reported health status , and estrogen use for women ( P for sex - FABP4 interaction 0.10 ) . - pubmed
BMI modified the FABP4 - diabetes relation ( P = 0.009 overall ; 0.02 for women and 0.135 for men ) , in that statistically significant higher risk of diabetes was mainly seen in men with BMI & lt;25 kg / m(2 ) ( HR per SD : 1.78 [ 95 % CI 1.13 - 2.81 ] ) . - pubmed
CONCLUSIONS : Plasma FABP4 was positively associated with incident diabetes in older adults , and such association was statistically significant in lean men only . - pubmed
All 19 neoplasms were positive for thyroid transcription factor 1 and thyroglobulin but negative for parathyroid hormone and calcitonin . - pubmed
Following the consumption of contaminated food or water by a human host , the Vibrio cholerae bacterium produces virulence factors , including cholera toxin ( CT ) , which directly causes voluminous diarrhea , producing cholera . - pubmed
CD8 + T - cell activation in HIV-1 - infected patients experiencing transient low - level viremia during antiretroviral therapy . - pubmed
We found that TLLV does not significantly change CD8 T - cell activation and that higher CD8 T - cell activation during viral suppression & lt;50 copies per milliliter is associated with a modest increase in the risk of a subsequent TLLV . - pubmed
Intra - acinar cell activation of digestion enzymes triggers the events of acute pancreatitis and stimulates the production of inflammatory cytokines . - pubmed
Finally , inflammatory cytokines trigger inflammatory cascades that lead to systemic inflammatory response syndrome , multi - organ failure , or death . - pubmed
However , a possible correlation between RBC MTX and MTXGlu2 - 5 concentrations and clinical outcomes of MTX treatment in RA is debated . - pubmed
Main changes of blood biochemical included hypokalemia , lactic acidosis , hyperglycemia , hypsocreatinkinase . - pubmed
Median overall survival for mucin positive and mucin negative tumors was 4(1.3 - 5.7 ) and 3.3(0.1 - 6.3 ) years respectively . - pubmed
Expected 5 year disease free and overall survival for mucin positive and mucin negative tumors was 73 % and 89 % ( P = 0.1 ) and 75 % and 87 % ( P = 0.4 ) . - pubmed
CONCLUSION : Acellular mucin pools in rectal cancer following a PCR to neoadjuvant treatment do not impact survival . - pubmed
RESULTS : Compared with men ( n = 765 ) , women ( n = 274 ) were older ( p & lt ; 0.001 ) and more likely to have hypertension ( p & lt ; 0.001 ) , diabetes ( p = 0.002 ) , and higher low - density lipoprotein cholesterol ( LDL - C ) ( p = 0.01 ) , high - density lipoprotein cholesterol ( p & lt ; 0.001 ) , and C - reactive protein ( CRP ) ( p = 0.004 ) levels . - pubmed
Greater PAV regression in women versus men occurred with rosuvastatin ( p = 0.004 ) , those with diabetes ( p = 0.01 ) , stable coronary disease ( p = 0.01 ) , higher baseline LDL - C ( p = 0.02 ) , and higher CRP ( p = 0.04 ) levels . - pubmed
Annexin A5 promotes invasion and chemoresistance to temozolomide in glioblastoma multiforme cells . - pubmed
Annexin A5 reportedly promotes progression and chemoresistance in a variety of cancers . - pubmed
In the present study , we explored the effects of annexin A5 on GBM cell invasion and chemoresistance to temozolomide . - pubmed
Stable overexpression and knockdown of annexin A5 were performed in both U-87 MG and U-118 MG human GBM cell lines . - pubmed
In conclusion , our study provides the first evidence that annexin A5 promotes GBM cell invasion , MMP-2 expression / activity , and chemoresistance to temozolomide through a PI3K - dependent mechanism . - pubmed
It adds new insights not only into the biological function of annexin A5 but also into the molecular mechanisms underlying GBM progression and chemoresistance . - pubmed
AIM : The treatment strategy for steroid - resistant nephrotic syndrome remains uncertain at present , especially in those with calcineurin inhibitor resistance or intolerance . - pubmed
To date , few studies have been published using multiple combination therapy of immunosuppressive reagents for children with calcineurin inhibitor - resistant or -intolerant nephrotic syndrome . - pubmed
Biochemical parameters included the following : ( a ) indices of CLGI ( high - sensitivity C - reactive protein , erythrocyte sedimentation rate and fibrinogen ) ; ( b ) insulin resistance ( Homeostasis Model Assessment of Insulin Resistance index ) ; ( c ) adiposity ( plasma adiponectin ) . - pubmed
Additionally , 3.8 % of the rifampin - resistant isolates showing no mutation in the rpoB gene were significantly associated with mixed infections ( chi(2 ) , 56.78 ; P & lt ; 0.01 ) . - pubmed
This study revealed for the first time that Manu2 was the predominant group in the cases of mixed infections , and this might be the main reason for heteroresistance and a possible mechanism for isolates without any mutation in the rpoB gene to become rifampin resistant . - pubmed
Relationship of endothelial area with VEGF - A , COX-2 , maspin , c - KIT , and DOG-1 immunoreactivity in liposarcomas versus non - lipomatous soft tissue tumors . - pubmed
Although DOG-1 is considered a specific marker for gastrointestinal tumors ( GISTs ) , its positivity , correlated with c - KIT and VEGF immunoexpression , was also shown by dermatofibrosarcomas and tumors with histiocytic and lipomatous differentiation , suggesting its possible pro - angiogenic role . - pubmed
Maspin expression was observed in adipose tissue tumors only . - pubmed
Regarding angiogenesis , 31 of the 55 cases were VEGF - positive , such positivity being directly correlated with COX-2 and CD34 positivity as evaluated in the tumor cells and also with MVD . - pubmed
Based on these aspects , we conclude that VEGF / COX-2 - induced angiogenesis is specific for non - lipomatous tumors , whereas liposarcomas are dependent on the VEGF / maspin angiogenic pathway . - pubmed
The DOG-1 / c - KIT / VEGF target may be used for further personalized therapy of soft tissue sarcomas . - pubmed
No data about DOG-1 and maspin positivity in liposarcomas have been published to date . - pubmed
The presence of a strong connection between reported COX-2 inhibitors and cardiac toxicity encourages medicinal chemists to explore new scaffolds . - pubmed
Starting from our lead compound 5a , structure - based drug - design was conducted and more potent analogues were obtained with high COX-2 selectivity and almost full edema protection , in carrageenan - induced edema assay , in case of compound 5e . - pubmed
No other demographic or clinical factors , such as cardiac disease , diabetes mellitus , smoking , lipid status , serum fibrinogen , hematocrit , antiphospholipid antibody titer , or ultrasound results of the carotid arteries entered the model . - pubmed
PURPOSE : The fully human monoclonal antibody nivolumab binds to the programmed death-1 ( PD-1 ) receptor , blocking interactions between PD-1 and its ligands on tumor cells and preventing T cell exhaustion in patients with cancer . - pubmed
In recent years , gefitinib , an epidermal growth factor receptor tyrosine kinase inhibitor , has shown its good antitumor activities in treating NSCLC in a number of studies . - pubmed
In this study , we identified a novel lncRNA , GClnc1 , which was upregulated and associated with tumorigenesis , tumor size , metastasis , and poor prognosis in gastric cancer . - pubmed
GClnc1 affected gastric cancer cell proliferation , invasiveness , and metastasis in multiple gastric cancer models . - pubmed
Mechanistically , GClnc1 bound WDR5 ( a key component of histone methyltransferase complex ) and KAT2A histone acetyltransferase , acted as a modular scaffold of WDR5 and KAT2A complexes , coordinated their localization , specified the histone modification pattern on the target genes , including SOD2 , and consequently altered gastric cancer cell biology . - pubmed
Thus , GClnc1 is mechanistically , functionally , and clinically oncogenic in gastric cancer . - pubmed
Targeting GClnc1 and its pathway may be meaningful for treating patients with gastric cancer . - pubmed
This study reveals that GClnc1 is an oncogenic lncRNA in human gastric cancer . - pubmed
High throughput chemical library screening identifies a novel p110 - delta inhibitor that potentiates the anti - myeloma effect of bortezomib . - pubmed
The phosphatidyl - inositol-3 - kinase ( PI3 K ) pathway is constitutively hyperactivated in MM to promote disease progression and drug resistance . - pubmed
While inhibiting PI3 K induces apoptosis in MM and is predicted to increase tumor susceptibility to anticancer therapy , early - generation pan - PI3 K inhibitors display poor clinical efficacy as well as intolerable side effects . - pubmed
Here , we found that PI3 K activity is significantly upregulated in MM cell lines and patient tumor cells resistant to bortezomib and that the majority of PI3 K activity in MM cells is dependent upon the p110 - delta isoform . - pubmed
Genetic or pharmacologic inhibition of p110 - delta substantially reduced myeloma viability and enhanced cellular sensitivity to bortezomib . - pubmed
Taken together , the results provide the basis for further clinical evaluation of p110 - delta inhibitors , as monotherapy or in synergistic combinations , for the benefit of MM patients . - pubmed
The Arabidopsis thaliana T - DNA insertion mutant glucose hypersensitive ( ghs ) 40 - 1 exhibited hypersensitivity to glucose ( Glc ) and abscisic acid ( ABA ) . - pubmed
Lung injury was accompanied by the upregulation of PLTP and IL-8 in the CSE - exposed rat model , and the number of white blood cells in the BALF was significantly increased compared with those of the controls . - pubmed
Topoisomerase 1 ( TOP1 ) poisons like camptothecin ( CPT ) are currently used in cancer chemotherapy but these compounds can have damaging , off - target effects on neurons leading to cognitive , sensory and motor deficits . - pubmed
Genomic pathways modulated by Twist in breast cancer . - pubmed
There is evidence to indicate that Twist expression plays a role in breast tumor formation and metastasis , but the role of Twist in dysregulating pathways that drive the metastatic cascade is unclear . - pubmed
Moreover , many of the genes and pathways dysregulated by Twist in cell lines and mouse models have not been validated against data obtained from larger , independant datasets of breast cancer patients . - pubmed
METHODS : We over - expressed the human Twist gene in non - metastatic MCF-7 breast cancer cells to generate the estrogen - independent metastatic breast cancer cell line MCF-7 / Twist . - pubmed
Microarray data was collected from both in vitro ( MCF-7 and MCF-7 / Twist cell lines ) and in vivo ( primary tumors and lung metastases ) models of Twist expression . - pubmed
RESULTS : Our data establishes a Twist over - expressing mouse model of breast cancer , which metastasizes to the lung and replicates some of the ontogeny of human breast cancer progression . - pubmed
CONCLUSIONS : Analogous gene expression patterns were observed in both in vitro and in vivo Twist preclinical models of breast cancer metastasis and breast cancer patient datasets supporting the functional role of Twist in promoting breast cancer metastasis . - pubmed
The data suggests that genetic dysregulation of Twist at the cellular level drives alterations in gene pathways in the Twist metastatic mouse model which are comparable to changes seen in human breast cancers . - pubmed
In ~50 % of prostate cancers , chromosomal rearrangements cause the fusion of the promoter and 5'-UTR of the androgen - regulated TMPRSS2 ( transmembrane protease , serine 2 ) gene to the open reading frame of ERG , encoding an ETS family transcription factor . - pubmed
ERG is not expressed in normal prostate epithelia , but when expressed , it promotes tumorigenesis via altered gene expression , stimulating epithelial - mesenchymal transition , cellular migration / invasion , and transformation . - pubmed
In conclusion , our findings have identified critical molecular mechanisms involving ERK - mediated ERG activation that could be exploited for therapeutic intervention in ERG - positive prostate cancers . - pubmed
Glycobiology of syndecan-1 in bacterial infections . - pubmed
Loss of Sdc1 in mice is a gain - of - function mutation that significantly decreases the susceptibility to several bacterial infections , suggesting that subversion of Sdc1 is an important virulence strategy . - pubmed
Here , we discuss several examples of Sdc1 subversion in bacterial infections . - pubmed
Synergistic antiproliferative effects of an mTOR inhibitor ( rad001 ) plus gemcitabine on cholangiocarcinoma by decreasing choline kinase activity . - pubmed
This study aims to investigate a novel therapeutic regimen [ gemcitabine plus everolimus ( rad001 ) , an mTOR inhibitor ] for cholangiocarcinoma . - pubmed
In the in vitro study , gemcitabine plus rad001 exerted a synergistic therapeutic effect on the cholangiocarcinoma cells , irrespective of the KRAS mutation status . - pubmed
In the xenograft study , gemcitabine plus rad001 showed the best therapeutic effect on tumor volume change , and was associated with increased caspase-3 expression , decreased eIF4E expression , as well as overexpression of both death receptor- and mitochondrial apoptotic pathway - related genes . - pubmed
We concluded that gemcitabine plus rad001 has a synergistic antiproliferative effect on cholangiocarcinoma , irrespective of the KRAS mutation status . - pubmed
PURPOSE OF REVIEW : Defining predisposition to allergic drug reactions has largely focussed on HLA associations , but other genetic and nongenetic factors are also likely to be involved . - pubmed
RECENT FINDINGS : Polymorphic genetic variants in cytokine genes , including IL-10 , and co - signalling pathways , including CTLA4 , have been associated with allergic drug reactions , but the effect size is lower than with HLA alleles and most associations have not been replicated . - pubmed
Although TCR specificity seems to be important for CBZ - induced SJS / TEN in South East Asian patients , a distinct repertoire may not play a role in reactions to other drugs . - pubmed
Histamine dysregulation has been identified as a rare genetic cause of tic disorders ; mice with a knockout of the histidine decarboxylase ( Hdc ) gene represent a promising model of this pathophysiology . - pubmed
The H3R histamine receptor is elevated in the striatum of Hdc KO mice , and H3R agonists , acting in the dorsal striatum , trigger tic - like movements in the model . - pubmed
Mutations in the collagen genes COL4A1 and COL4A2 cause Mendelian eye , kidney and cerebrovascular disease including intracerebral haemorrhage ( ICH ) , and common collagen IV variants are a risk factor for sporadic ICH . - pubmed
COL4A1 and COL4A2 mutations cause endoplasmic reticulum ( ER ) stress and basement membrane ( BM ) defects , and recent data suggest an association of ER stress with ICH due to a COL4A2 mutation . - pubmed
We performed a preventative oral treatment of Col4a1 mutant mice with the chemical chaperone phenyl butyric acid ( PBA ) , which reduced adult ICH . - pubmed
However , PBA treatment did not alter eye and kidney defects , establishing tissue - specific outcomes of targeting Col4a1 - derived ER stress , and therefore this treatment may not be applicable for patients with eye and renal disease . - pubmed
Alleviating ER stress is a valid therapeutic target for preventing and treating established adult ICH , but collagen IV patients will require stratification based on their clinical presentation and mechanism of their mutations . - pubmed
Furthermore , to evaluate the molecular mechanism involved in cancer cell death , we studied the genes that are involved in fatty acid and cholesterol biosynthesis pathway including 3 - hydroxy-3 - methylglutaryl - coenzyme A reductase ( HMGCR ) , Acetyl CoA synthase ( ACC ) , sterol regulatory element - binding protein ( SPREPB1 ) and fatty acid synthase ( FASN ) respectively . - pubmed
HMGB1 gene polymorphism is associated with coronary artery lesions and intravenous immunoglobulin resistance in Kawasaki disease . - pubmed
Recent reports of elevated serum high mobility group box 1 ( HMGB1 ) level during the acute phase of KD and its relationship to poor response to IVIG treatment suggest a possible association of HMGB1 polymorphisms with KD . - pubmed
We investigated the association between the polymorphisms of the HMGB1 gene , KD susceptibility , coronary artery lesions , and KD response to IVIG treatment . - pubmed
RESULTS : The HMGB1 single nucleotide polymorphisms were not associated with KD susceptibility . - pubmed
CONCLUSION : The rs1412125 in HMGB1 might be a risk factor for the development of coronary artery lesions and IVIG resistance in KD patients . - pubmed
Additionally , we provided evidence that DNMTs control the global hypomethylation of oncogenes , including ALOX5AP and CSF3R that otherwise have high methylation in normal colons . - pubmed
Such genes were also more sensitive to DNMT changes , such as in CRC . - pubmed
Two comparative assessments of intravenous immunoglobulin therapy switching patterns in the treatment of chronic inflammatory demyelinating polyneuropathy in the US . - pubmed
Tapentadol is a novel analgesic molecule that synergistically combines two mechanisms of action , micro - opioid receptor agonism and norepinephrine reuptake inhibition , and for which multiple literature data are available that confirm its efficacy and safety in controlling pain . - pubmed
Computational screening of phytochemicals against survivin protein : A potent target for cancer . - pubmed
RESULTS : EOCs were heterogeneous , frequently harboring KRAS , PIK3CA , PTEN , CTNNB1 , ARID1A and TP53 mutations . - pubmed
EOCs were distinct from HGSOCs at the mutational level , less frequently harboring TP53 but more frequently displaying KRAS , PIK3CA , PIK3R1 , PTEN and CTNNB1 mutations . - pubmed
Compared to synchronous EOCs and pure EECs , pure EOCs less frequently harbored PTEN , PIK3R1 and ARID1A mutations . - pubmed
Akin to EECs , EOCs could be stratified into the four molecular subtypes : 3 % POLE ( ultramutated ) , 19 % MSI ( hypermutated ) , 17 % copy - number high ( serous - like ) and 61 % copy - number low ( endometrioid ) . - pubmed
In addition to microsatellite instability , a subset of EOCs harbored potentially targetable mutations , including AKT1 and ERBB2 hotspot mutations . - pubmed
AIMS : To examine whether the presence of two common missense variants in the CYP2C9 gene ( rs1799853 , encoding Arg144Cys and denoted as * 2 , and rs1057910 , encoding Ile359Leu and denoted as * 3 ) influences the acute physiological response to a single glipizide dose in individuals naive to diabetes medications . - pubmed
CONCLUSIONS : Carriers of two reduced function alleles in CYP2C9 may experience an increased insulin response to glipizide and be predisposed to a higher risk of hypoglycaemia , although no effect of genotype was seen in glucose - based measurements . - pubmed
Material and methods : In the Maria Sklodowska - Curie Institute - Oncology Centre , between 2011 and 2017 , 318 non - resectable or metastatic melanoma patients were treated with immune checkpoint inhibitors : anti - CTLA-4 or / and anti - PD-1 . - pubmed
Among this group 10 % of patients had brain metastases , 24 % of patients had BRAF mutant melanoma , and co - morbidities were present in 86 % of patients ( mainly hypertension , cardiovascular diseases and/or diabetes ) . - pubmed
This integrative analysis revealed that tumors with high stromal clustering and barrier had reduced expression of pathways involved in naive CD4 signalling , MAPK and PI3 K signalling . - pubmed
Endothelin-1 ( ET-1 ) , an endogenous vasoactive peptide , has been found to play an important role in peripheral pain signaling . - pubmed
Acid - sensing ion channels ( ASICs ) are key sensors for extracellular protons and contribute to pain caused by tissue acidosis . - pubmed
Finally , we showed that pharmacological blockade of ASICs by amiloride or APETx2 significantly alleviated ET-1 - induced flinching and mechanical hyperalgesia in rats . - pubmed
Tooth extractions in patients under antiresorptive therapy for osteoporosis : Primary closure of the extraction socket with a mucoperiosteal flap versus application of platelet - rich fibrin for the prevention of antiresorptive agent - related osteonecrosis of the jaw . - pubmed
PURPOSE : The aim of this study was to compare primary closure of the extraction socket to application of platelet - rich fibrin ( PRF ) without subsequent primary closure for the prevention of osteonecrosis of the jaw ( ONJ ) in patients administered antiresorptive therapy for osteoporosis . - pubmed
RECOMMENDATIONS : In the adjuvant setting , nivolumab or pembrolizumab should be offered to patients with resected stage IIIA / B / C / D BRAF wild - type cutaneous melanoma , while either of those two agents or the combination of dabrafenib and trametinib should be offered in BRAF - mutant disease . - pubmed
In the unresectable / metastatic setting , ipilimumab plus nivolumab , nivolumab alone , or pembrolizumab alone should be offered to patients with BRAF wild - type cutaneous melanoma , while those three regimens or combination BRAF / MEK inhibitor therapy with dabrafenib / trametinib , encorafenib / binimetinib , or vemurafenib / cobimetinib should be offered in BRAF - mutant disease . - pubmed
lncRNA - PRLB Confers Paclitaxel Resistance of Ovarian Cancer Cells by Regulating RSF1 / NF - kappaB Signaling Pathway . - pubmed
Background : The long noncoding RNA ( lncRNA)-PRLB ( progression - associated lncRNA in breast cancer ) has been identified to enhance the drug resistance of breast cancer cells . - pubmed
In this study , the authors explored PRLB effect in the paclitaxel ( Tax ) resistance of ovarian cancer cells and revealed the role of RSF1 ( remodeling and spacing factor 1)/nuclear factor kappaB ( NF - kappaB ) signaling in this process . - pubmed
The expressions of PRLB in Tax resistant tissues and cells of ovarian cancer were detected using the real time polymerase chain reaction assay . - pubmed
Results : PRLB expression was obviously enhanced in the Tax resistant ovarian cancer tissues and cells . - pubmed
Conclusion : This study reveals that knockdown of PRLB improves the sensitivity of ovarian cancer cells to Tax , at least in part , through inhibiting the activation of RSF1 / NF - kappaB signaling through targeting miR-150 - 5p . - pubmed
While IMCL content scales negatively with insulin resistance , athletes are highly insulin sensitive in contrast to T2D patients , the so - called athlete 's paradox . - pubmed
Thus , we developed a novel fluorescent super - resolution microscopy approach and found that PLIN2 protein abundance at the LD surface was higher in T2D patients than in athletes . - pubmed
While PLIN5 abundance at the LD surface was similar in athletes and T2D patients , we have observed previously that the number of PLIN5 decorated LDs was higher in athletes , indicating more LDs in close association with mitochondria . - pubmed
Anti - cN1A antibodies do not correlate with specific clinical , EMG or pathological findings in sporadic inclusion body myositis . - pubmed
INTRODUCTION : Anti - cytosolic 5 '- nucleotidase 1A ( cN1A ) antibodies are commonly detected in patients with sIBM . - pubmed
RESULTS : Anti - cN1A antibodies were present in 47/92 ( 51 % ) patients with sIBM . - pubmed
The antibody titer did not correlate with the clinical phenotype , CK value or presence of myotonic discharges on EMG . - pubmed
Anti - cN1A antibody positive patients appeared to have more frequent auto - aggressive inflammation on muscle biopsy but not as an isolated myopathological feature . - pubmed
DISCUSSION : Our study showed that anti - cN1A antibody positive and negative sIBM patients have similar clinical features and disease severity . - pubmed
Anti - cN1A antibodies in our sIBM cohort did not correlate with any studied clinical or laboratory parameter and , therefore , were of limited value in the patient 's assessment . - pubmed
5 - Hydroxy-4 - methoxycanthin-6 - one alleviates dextran sodium sulfate - induced colitis in rats via regulation of metabolic profiling and suppression of NF - kappaB / p65 signaling pathway . - pubmed
A UPLC - Q - TOF - MS / MS approach - based metabolomics analysis was conducted to explore the underlying mechanisms of PQ - A in colitis treatment . - pubmed
CONCLUSIONS : We provide an overview of PQ - A 's possible mechanism of action in colitis treatment based on serum non - targeted metabolomics . - pubmed
PQ - A treatment can protect rats against DSS - induced colitis by suppressing the NF - kappaB / p65 signaling pathway . - pubmed
Patients with critical disease had significantly lower levels of anti - HCoV OC43 - NP ( p = 0.016 ) and HCoV HKU1 - NP ( p = 0.023 ) antibodies at the first encounter compared to other COVID-19 patients . - pubmed
Endothelin-1 caused a significant decrease in UF , UNaV and UKV only at a later period , despite a relatively early depression of renal haemodynamics . - pubmed
In this study we compared 2 putative biochemical markers for rejection of pancreas allografts , serum immunoreactive anodal trypsinogen and urinary amylase , with serum creatinine in 15 simultaneously transplanted type I diabetics . - pubmed
ISDN and its two main hepatic metabolites , isosorbide-2 - mononitrate ( IS-2 - MN ) and isosorbide-5 - mononitrate ( IS-5 - MN ) were compared for their ability to inhibit platelet aggregation and thromboxane B2 generation in vitro in response to threshold concentrations of ADP , adrenaline , collagen , thrombin and arachidonic acid . - pubmed
Characterization of mammalian type IX collagen fragments from limited pepsin digests of a transplantable swarm rat chondrosarcoma . - pubmed
Collagenous fragments from type IX molecules have been solubilized by limited pepsin proteolysis of a transplantable rat chondrosarcoma and isolated by selective salt precipitation . - pubmed
streptokinase ( SK ) in the treatment of acute myocardial infarction ( AMI ) in two cardiac care units . - pubmed
The time interval from the beginning of acute symptoms to the arrival at the hospital was 2.8 + /- 1.2 hours ( 1 to 15 ) and from that moment to administration of SK was 1.6 + /- 1.4 h. The whole interval to the administration of SK was 4.4 + /- 2.5 h. RESULTS : The 3 criteria of reperfusion ( pain relief , ST changes resolution and less than 18 h maximum CK rise ) were present in 36 % of the pts , 2 of the criteria in 21 % , and 41 % of the pts had only one or no criteria . - pubmed
Role of insulin and counter - regulatory hormones in the control of hepatic glycerolipid synthesis and low - density - lipoprotein catabolism in diabetes . - pubmed
[ High - dose immunoglobulins in immune thrombocytopenic purpura ] . - pubmed
Twenty - four patients with immune thrombocytopenic purpura ( ITP ) were treated with high doses of intravenous immunoglobulin ( Ig ) . - pubmed
Alpha 1 - fetoprotein and carbonic anhydrase B and C concentration in cord blood from newborn infants of diabetic mothers . - pubmed
[ Prolactin adenoma in a irl whose mother had had a pituitary adenoma with amenorrhea - galactorrhea ] . - pubmed
Serial renal biopsies for glomerular culture , histochemical staining for beta - glucuronidase , electron microscopy ( EM ) and light microscopy , were used to study macrophage involvement in experimental chronic immune complex ( IC ) glomerulonephritis ( GN ) induced in rabbits by daily intravenous injections of bovine serum albumin ( BSA ) . - pubmed
We conclude that opiate receptor stimulation by morphine causes inhibition of the vagally mediated component of water - induced bronchoconstriction . - pubmed
The effect of oral Kallikrein treatment on sperm motility in asthenozoospermia . - pubmed
Nineteen men with asthenozoospermia were treated with oral Kallikrein ( 600 U daily for 12 weeks ) and sperm motility evaluated in 16 of these patients . - pubmed
[ Phase-1 study of the tolerance for increasing doses of recombinant human alpha 2 interferon in patients with advanced cancer ] . - pubmed
Thirteen patients with malignant tumors were entered into a phase I trial with recombinant DNA human alpha 2 interferon ( IFN alpha 2 ) . - pubmed
Defective Fc receptor - mediated function of the mononuclear phagocyte system in lupus nephritis . - pubmed
To determine whether patients with systemic lupus erythematosus and nephritis have more profound defects in mononuclear phagocyte system clearance than their counterparts without renal disease , we studed Fc receptor - mediated splenic clearance function in 32 patients . - pubmed
Neither B8 nor DR3 histocompatibility antigen markers differentiated the renal and nonrenal disease subgroups . - pubmed
The greater Fc receptor - mediated clearance dysfunction , which occurs in patients with lupus erythematosus and nephritis , could lead to enhanced glomerular deposition of immune complexes as a primary event , or as a secondary event amplifying previously established lesions . - pubmed
A group of patients with stage T1B2 disease and pathologically negative lymph nodes showed excellent 10 - year survival rates and freedom from clinical evidence of disease , while prostate specific antigen ( PSA ) correlations in 10 - year survivors indicate that 88 % were clinically free of cancer and had a PSA level of less than 4.0 mg./nl . - pubmed
In serial samples from nine posttransfusion hepatitis C patients , NS5 and E2 antibodies did not appear earlier than classical HCV antibodies . - pubmed
Re : " Alcohol , smoking , coffee , and cirrhosis " and " coffee and serum gamma - glutamyltransferase : a study of self - defense officials in Japan " . - pubmed
[ Antigenemia and CD4 + cell count in HIV-1 infected patients ] . - pubmed
In a peptide competition cytotoxicity ( PCC ) assay , based on inhibition of CTL lysis by competition for binding to MHC class - I molecules between a known CTL epitope - containing peptide and peptide of interest , E7 49 - 57 bound 45 - fold more efficiently to Db than the second Db - binding peptide in line . - pubmed
The abnormal proliferation of cardiac fibroblasts and deposition of the ECM protein , collagen , associated with hypertension and myocardial infarction , may adversely affect the performance of the heart . - pubmed
Angiotensin II , aldosterone and endothelins play a central role in the remodeling of the ECM in hypertension , and decrease collagenase activity and/or increase collagen synthesis in cultured cells . - pubmed
Angiotensin II is a principal determinant in vivo of cardiac fibroplasia and synthesis of the ECM proteins , collagen and fibronectin . - pubmed
Cardiac fibroblasts respond to angiotensin II with hyperplastic / hypertrophic growth , and increased expression of collagen , fibronectin , and integrins . - pubmed
Association of protease activity against IGFBP-3 with peritoneal fluid mitogens : possible implications for the ectopic growth of endometrial cells in women with endometriosis . - pubmed
BACKGROUND : Recent data indicate the implication of an IGF / IGFBP / protease system in the development of ectopic implants of endometrium ( endometriosis ) in the pelvic cavity . - pubmed
MATERIAL AND METHODS : We characterized mitogens and protease(s ) against IGFBP-3 in the peritoneal fluid of women with or without endometriosis using preparative isoelectric focusing ( IEC ) Proteineous fractions were tested for a ) mitogenic activity on NIH / 3T3 cells and KLE endometrial - like cells , b ) proteinolytic activity against radiolabeled IGFBP-3 , and c ) protein analysis using SDS - PAGE . - pubmed
CONCLUSION : The preparative isoelectric focusing system would be an advantageous approach to investigate the possible implication of the PF proteases with IGFBP-3 limited proteolysis generating PF mitogen(s ) which possibly participate in the pathophysiology of endometriosis . - pubmed
Fas - mediated cytotoxicity was quantified by counting the number of cells present in discrete patches of OSE 0 and 8 h after Fas mAb treatment . - pubmed
Further studies should establish whether the beta3AR is coupled to other signaling pathways in human brown adipocytes and whether these may contribute to BAT hypertrophy and/or thermogenesis . - pubmed
Molecular analysis of the cholera toxin gene & amp ; antibiotic sensitivity profile of Vibrio cholerae O1 & amp ; O139 associated with mixed infection . - pubmed
To determine whether glucocorticoid resistance due to mutations in the glucocorticoid receptor ( GRL ) gene is associated with premature pubarche , hirsutism , or oligo / amenorrhea , we performed single - strand conformational polymorphism analysis of genomic DNA obtained from 25 children and 16 adolescent girls referred for the evaluation of premature pubarche , hirsutism , or oligo / amenorrhea . - pubmed
We conclude that glucocorticoid resistance due to GRL mutations is an infrequent cause of mild hyperandrogenism . - pubmed
Hb saale OR alpha 2beta 2 84(EF8)Thr --> ; Ala. A new abnormal hemoglobin was detected in a young German anemic patient by cation - exchange high performance liquid chromatography ( HPLC ) . - pubmed
Minor manifestations include fever , arthralgia and laboratory findings of elevated erythrocyte sedimentation rate , C - reactive protein and prolonged PR interval on ECG . - pubmed
[ Telomerase activity in liver cancer and the adjacent tissue ] . - pubmed
OBJECTIVE : To investigate the possibility of using telomerase as a tumor marker for human primary hepatocellular carcinomas ( HCC ) . - pubmed
METHODS : Human liver specimens , comprising 33 HCC and adjacent peritumoral tissues , 4 hepatic metastases and the adjacent peritumoral tissues , 6 benign liver lesions and 6 normal liver tissues , were examined for telomerase activity by TRAP assay based on PCR . - pubmed
Telomerase activity was negative in 6 nomal liver tissues and 5 of 6 benign liver lesions . - pubmed
There was no correlation between the clinical stage of HCC and their telomerase activity . - pubmed
CONCLUSION : Positive telomerase activity occurs in the majority of HCC examined . - pubmed
Subsequent studies suggested that protein kinase C - dependent and tyrosine kinase - dependent pathways are important in LB induction during hypoxia . - pubmed
Immune system in adults with childhood - onset growth hormone deficiency : effect of growth hormone therapy . - pubmed
OBJECTIVE : To investigate the impact of growth hormone ( GH ) therapy in adults with childhood - onset GH deficiency on immune system . - pubmed
METHODS : Ten young GH deficient adults ( 7 males , age 19 - 28 years ) were treated with recombinant human growth hormone for 6 months . - pubmed
These observations suggest a temporary immune complex formation after the onset of GH treatment which might play a partial role in developing oedema as a side effect of GH treatment , besides the known effect of GH on water retention . - pubmed
CONCLUSIONS : GH therapy in GH deficient young adults has a measurable effect on the increase of CD4 / CD8 ratio and on the formation of immune complexes . - pubmed
Aptamer significantly reduced the thrombin - induced platelet degranulation ( 46+/-20 % inhibition at 0.15 U / ml thrombin , P<.001 ) , as well as thrombin - mediated platelet aggregation in PRP ( 7+/-10 % inhibition at 1 U / ml thrombin , P<.05 ) . - pubmed
BRCA1 carries tumor suppressor activity distinct from that of p53 and p21 . - pubmed
The loss of BRCA1 function appears as an essential step in breast and ovarian epithelial cells oncogenesis and is consistent with the concept that BRCA1 acts as a tumor suppressor gene . - pubmed
In 1996 , a retroviral vector was used for BRCA1 delivery to demonstrate that the transfer of BRCA1 inhibits breast and ovarian cancer cell growth . - pubmed
Since this early observation , the tumor growth inhibitory activity of BRCA1 in vivo has not been further documented . - pubmed
Delivery of wild - type BRCA1 by an adenovirus vector in breast and ovarian tumor cells , decreases in vitro proliferation and tumorigenicity . - pubmed
Similarly , in vivo administration of BRCA1 provokes tumor growth retardation or regression comparable to that obtained with p53 or p21 . - pubmed
[ ACE - dependent and sympathetic components of blood pressure regulation in patients with essential hypertension ] . - pubmed
UNLABELLED : The development of arterial hypertension is accompanied by impairment of the normal ratio of the " ACE - depending " and of the sympathetic nervous system , correlates with the action on the main pharmacological " targets " : I - I - imidazoline receptors ( moxonidine ) or the ACE activity ( enalapril ) . - pubmed
The aim of the present investigation was to determine the hypotensive and metabolic effects of moxonidine and enalapril depending on the basal ACE activity in patients with arterial hypertension , complicated with the metabolic syndrome . - pubmed
Effectiveness of moxonidine and enalapril administration ( during 24 weeks ) depended on the basal ACE activity in the hypertensive patients : ( a ) in the group of patients with low basal ACE activity moxonidine very effectively decreased systolic and diastolic blood pressure , compared with the group of patients with high basal ACE activity ; ( b ) influence of enalapril on the level of arterial blood pressure was more pronounced with high basal ACE activity . - pubmed
IN CONCLUSION : choosing a hypotensive treatment for patients with the metabolic syndrome , it is advisable to take into account the basal ACE activity levels . - pubmed
Spinal PGE ( 2 ) application facilitated dorsal horn neuronal firing elicited by ionophoretic delivery of NMDA , suggesting that an interaction of PGs and NMDA receptors may contribute to inflammation - induced central sensitization . - pubmed
Maple syrup urine disease ( MSUD ) is an inborn error of metabolism stemming from a deficiency in 2 - ketoacid dehydrogenase and resulting in the systemic accumulation of branched chain amino acids ( BCAAs ) . - pubmed
Misexpression of dHAND in the anterior compartment of the limb bud induces ectopic expression of sonic hedgehog , with resulting preaxial polydactyly and mirror image duplications of posterior digits . - pubmed
The solute carrier gene family SLC26 consists of tissue - specific anion exchanger genes , three of them associated with distinct human recessive disorders . - pubmed
Interleukin-6 release in the hepatic blood outflow during normothermic liver ischaemia in humans . - pubmed
In liver ischaemia - reperfusion injury , cytokines play a key proinflammatory role . - pubmed
AIMS : The aim of our study was to analyse the cytokine pattern in the hepatic blood outflow in patients undergoing surgical intervention of partial liver resection with clamping of the hepatic pedicle and liver ischaemia , and to correlate the cytokine behaviour with clinical parameters . - pubmed
RESULTS : We found a significant increase of the IL-6 levels in the supra - hepatic samples during liver ischaemia , while the trend with IL-1alpha was less clear ; IFN - gamma and TNF - alpha were undetectable with the methods used . - pubmed
IL-6 levels appeared to correlate positively with bilirubin and gamma - GT levels and negatively with the degree of acidosis . - pubmed
Cytokines could contribute to modulate the inflammatory response to liver ischaemia . - pubmed
Blockade of airway inflammation and hyperresponsiveness by HIV - TAT - dominant negative Ras . - pubmed
In this study , we evaluated the role of Ras in Ag - induced airway inflammation and hyperresponsiveness by i.p . - pubmed
OVA challenge also caused airway hyperresponsiveness to methacholine , which was dose dependently blocked by treatment with TAT - dnRas . - pubmed
By contrast , TAT - green fluorescent protein or dnRas lacking the TAT protein transduction domain did not block airway inflammation , cytokine production , or airway hyperresponsiveness . - pubmed
We conclude that Ras mediates Th2 cytokine production , airway inflammation , and airway hyperresponsiveness in immune - sensitized mice . - pubmed
Previous molecular biological analysis documented that MUTZ-11 cells carry both an FLT3 internal tandem duplication ( ITD ) and an MLL partial tandem duplication ( PTD ) . - pubmed
molecular biological alterations ( FLT3 ITD + MLL PTD ) . - pubmed
Ligands of peroxisome proliferator - activated receptor gamma ( PPARgamma ) have been shown to inhibit growth in different tumor cell lines . - pubmed
Activation of PPARgamma by its synthetic ligands might have a therapeutic role in advanced NB . - pubmed
A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin . - pubmed
RESULTS : MMP-2 , MMP-9 , uPA , PAI-1 , IGF-2 , BFGF , VEGF , ANG-1 , IRS-1 , and TSP-1 were significantly ( p & lt ; or = 0.05 ) upregulated in CIS and INV , whereas TIMP-1 , ANG-2 , MASPIN , IGF1 - R and HBEGF were unchanged . - pubmed
IGF-1 was uniquely elevated in IDP . - pubmed
SPARC was downregulated in CIS . - pubmed
Induction of epithelial cell apoptosis in the uterus by a mouse uterine ischemia - reperfusion model : possible involvement of tumor necrosis factor - alpha . - pubmed
Ischemia - reperfusion - induced endometrial apoptosis was markedly decreased in TNF - R p55 - deficient mice , confirming the essential role of TNFalpha in the induction of apoptosis by ischemia - reperfusion ( n = 4 ) . - pubmed
Our results suggest that ischemia - reperfusion and subsequent TNFalpha expression may be critical factors in inducing endometrial cell apoptosis . - pubmed
This finding is of interest because reduction of brain membrane fluidity impairs memory formation and both decreased PLA2 activity and reduced membrane fluidity have been reported in the brain from patients with Alzheimer ' s disease . - pubmed
However , chronic expression of the DSCR1 ( Adapt78 ) gene has now been implicated in several pathological conditions including Alzheimer ' s disease , Down syndrome and cardiac hypertrophy . - pubmed
Association of amino acid variants in the activating transcription factor 6 gene ( ATF6 ) on 1q21 - q23 with type 2 diabetes in Pima Indians . - pubmed
Functionally important segments of ATF6 were sequenced in 15 diabetic and 15 nondiabetic Pimas and representative single nucleotide polymorphisms ( SNPs ) tested for association with type 2 diabetes in 900 - 1,000 subjects . - pubmed
Pro(145)Ala and Ser(157)Pro were in a complete linkage disequilibrium and showed a nominal association with type 2 diabetes ( P = 0.05 ; odds ratio 2.3 [ 95 % CI 1.0 - 5.2 ] ) and with 30 - min plasma insulin during oral glucose tolerance test in 287 nondiabetic individuals ( P = 0.045 ) . - pubmed
Although the associations with type 2 diabetes and plasma insulin levels are marginal and their functional consequences are yet unknown , all three amino acid substitutions are located in a functionally important part of ATF6 . - pubmed
Signaling was disrupted by heterologous expression of TRbeta receptors with mutations in the ligand - binding domain that are associated with neurological disorders in humans , but not by mutations that disrupt DNA binding . - pubmed
Mechanisms regulating tumor angiogenesis by 12 - lipoxygenase in prostate cancer cells . - pubmed
Increased expression of 12 - lipoxygenase has been documented in a number of carcinomas . - pubmed
When overexpressed in human prostate or breast cancer , 12 - lipoxygenase promotes tumor angiogenesis and growth in vivo . - pubmed
Neutralization of VEGF by a function - blocking antibody significantly decreased the ability of 12 - lipoxygenase - transfected PC-3 cells to stimulate endothelial cell migration , suggesting VEGF as an important effector for 12 - lipoxygenase - mediated stimulation of tumor angiogenesis . - pubmed
Induction of Gas6 protein in CCl4 - induced rat liver injury and anti - apoptotic effect on hepatic stellate cells . - pubmed
In liver , after an acute or chronic injury , repair involves macrophages and hepatic stellate cells ( HSC ) activated into myofibroblastic cells ( HSC / MFB ) , which produce cytokines and matrix proteins . - pubmed
Three days after CCl4 - induced liver injury in the rat , we detected the expression of Gas6 in ED1 - positive macrophages as well as in desmin - positive HSC , which accumulated in injured areas . - pubmed
In conclusion , Gas6 is a survival factor for these cells and we suggest that Gas6 , secreted by macrophages and HSC / MFB in vivo after liver injury , promotes HSC and HSC / MFB survival and might support transient HSC / MFB accumulation during liver healing . - pubmed
Beta - escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21(waf1 / cip1 ) in colon cancer cells . - pubmed
Results also indicate that beta - escin inhibited growth of colon cancer cells with either wild - type or mutant p53 . - pubmed
Two autosomal recessive muscle diseases , limb girdle muscular dystrophy type 2B ( LGMD2B ) and Miyoshi myopathy ( MM ) , are caused by mutations in the dysferlin gene . - pubmed
However , many patients who share clinical features with MM - type muscular dystrophy do not carry mutations in dysferlin gene . - pubmed
To understand the basis of MM that is not due to mutations in dysferlin gene , we analyzed cells from patients in one such family . - pubmed
These results add to the existing evidence that cell membrane repair defect may be responsible for MM - type muscular dystrophy and indicate that a previously unsuspected genetic lesion that affects cell membrane repair pathway is responsible for the disease in the non - dysferlin MM patients . - pubmed
Gut hyperpermiability after ischemia and reperfusion : attenuation with adrenomedullin and its binding protein treatment . - pubmed
Our previous studies have shown that administration of adrenomedullin ( AM ) , a novel vasoactive peptide , and its binding protein ( AMBP-1 ) , reduces the systemic inflammatory response and organ injury after systemic ischemia induced by hemorrhagic shock . - pubmed
However , it remains unknown whether administration of AM / AMBP-1 preserves gut barrier function after gut ischemia reperfusion ( I / R ) . - pubmed
We therefore hypothesized that AM / AMBP-1 prevents structural and functional damages to the intestinal mucosa after gut I / R. To test this , gut ischemia was induced by placing a microvascular clip across the superior mesenteric artery ( SMA ) for 90 min in male adult rats . - pubmed
Predictive value of coronary artery stenoses and C - reactive protein levels in patients with stable coronary artery disease . - pubmed
We sought to assess the prognostic value of non - obstructive coronary stenoses and C - reactive protein ( CRP ) levels in patients with chronic stable angina ( CSA ) . - pubmed
Age , previous history of AMI , vessel score , extension score and CRP levels were significantly associated with the study end - point . - pubmed
CONCLUSIONS : In patients with CSA , independently of revascularization , extension score and CRP levels predict cardiac adverse events , regardless of the presence or absence of flow limiting coronary lesions . - pubmed
Subsequent operation and pathologic examination of the mass revealed a multicystic neoplasm consisting of malignant mesenchymal cells immunohistochemically positive for vimentin and actin . - pubmed
AIMS : There is no cure for pulmonary arterial hypertension , but current approved treatment options include prostanoids , endothelin - receptor antagonists , and phosphodiesterase type-5 inhibitors . - pubmed
Assessment of insulin sensitivity / resistance and their relations with leptin concentrations and anthropometric measures in a pregnant population with and without gestational diabetes mellitus . - pubmed
Insulin resistance assessed by homeostasis model assessment for insulin resistance ( HOMA - IR ) method was significantly higher in GDM patients compared to their NGT weight - matched control group . - pubmed
In contrast , the insulin sensitivity calculated from quantitative insulin sensitivity check index ( QUICKI - IS ) equation was significantly lower in GDM group . - pubmed
Women with GDM had significantly higher levels of serum insulin and leptin concentrations when compared with the NGT group . - pubmed
We did not find any correlation between leptin levels and insulin resistance ; we found negative correlation between leptin levels and insulin sensitivity . - pubmed
Thus , we observed that leptin may contribute development of GDM by decreasing insulin sensitivity but not increasing insulin resistance . - pubmed
Telomere maintenance mechanisms , such as telomerase activity and alternative telomere lengthening , provide the basis of malignant cell expansion independent of telomere shortening - induced apoptosis or senescence , ensuring tumor survival . - pubmed
Such a retinal - protein heterogeneity disappears in reduced bR which is known to have a planar ( nondistorted ) retinal conjugated system , resulting in a monophasic CD with reduced rotational strength , as observed . - pubmed
Positive conversion of tuberculin skin test and performance of interferon release assay to detect hidden tuberculosis infection during anti - tumor necrosis factor agent trial . - pubmed
OBJECTIVES : To evaluate tuberculin skin tests ( TST ) and interferon - gamma ( IFN - gamma ) assay in the detection of latent tuberculosis ( TB ) infection during tumor necrosis factor ( TNF ) antagonist treatment in Korean patients with initial negative TST result . - pubmed
METHODS : Eighty - six patients with rheumatic diseases who had received anti - TNF agents for over one year were investigated . - pubmed
Among 28 TST positive conversion cases , 4 patients with AS and 1 with psoriatic arthritis had positive IFN - gamma assay results , and one of them developed miliary TB . - pubmed
However , none of the 4 RA patients with positive IFN - gamma assay showed TST conversion . - pubmed
CONCLUSION : Serial TST with IFN - gamma assay may be useful to identify false - negative response to cases of latent Mycobacterium tuberculosis infection and new TB infections in patients with immune mediated inflammatory diseases during longterm anti - TNF therapy , especially in areas with intermediate TB burden . - pubmed
Three subjects were found to have deletions in the globin gene cluster , including a beta - thalassaemia due to deletion of HBB ( beta - globin gene ) , an HPFH due to deletions of HBD ( delta - globin gene ) and HBB , and an HPFH due to a novel HBG2 - HBG1 fusion gene consisting of exons 1 and 2 of HBG2 ( ( G)gamma - globin gene ) and exon 3 of HBG1 ( ( A)gamma - globin gene ) . - pubmed
OBJECTIVES : To assess the utility of kinetics for ultrasensitive prostate - specific antigen ( uPSA ) assays to identify men who are at risk of developing high - risk recurrent prostate cancer [ prostate - specific antigen doubling time ( PSADT ) & lt ; 9 months ] after radical prostatectomy . - pubmed
Role of the Fcgamma receptor IIIA - V / F158 polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis : a meta - analysis . - pubmed
OBJECTIVE : To perform a meta - analysis to assess the risk of the Fc - gamma receptor type IIIA ( FcgammaRIIIA)-V / F158 polymorphism for lupus nephritis and systemic lupus erythematosus ( SLE ) . - pubmed
CONCLUSIONS : The FcgammaRIIIA - V / F158 polymorphism might be a common susceptibility factor for SLE and lupus nephritis and play an important role in the overall development of SLE , showing different risks within ethnic populations , which should provide novel insights into the pathogenesis of the disease . - pubmed
This effect has been elucidated to be mediated through modulation of Achaete - Scute Complex Like 1 ( ASCL1 ) , a transcription factor associated with poor prognosis in neuroendocrine cancer . - pubmed
The Notch pathway has been shown to be inactive in MTC which may lead to altered expression of ASCL1 . - pubmed
Artificial induction of Notch signaling in MTC cells can suppress ASCL1 expression , the cell growth as well as hormone secreting potential . - pubmed
Pharmacological activation of the Notch pathway also successfully suppresses the tumor growth in an animal model , which sheds light on the targeted therapy of Notch as a potential treatment for intractable MTC . - pubmed
Hypoxia - inducible factor-1alpha ( HIF-1alpha ) is a critical regulatory protein of cellular response to hypoxia , and regulates the transcription of many genes involved in key aspects of cancer biology , including immortalization , maintenance of stem cell pools , cellular dedifferentiation , vascularization , and invasion / metastasis . - pubmed
HIF-1alpha has been implicated in the regulation of genes involved in angiogenesis , for example , VEGF and is associated with tumor progression . - pubmed
In the last decade , over expression of HIF-1alpha has been demonstrated in many common human cancers and emerging as a validated target for anticancer drug discovery . - pubmed
Dissection of the genetics of Parkinson ' s disease identifies an additional association 5 ' of SNCA and multiple associated haplotypes at 17q21 . - pubmed
Although dyslipidemia is the most influential and least treated factor , the greatest benefit for CVD prevention is obtained with integrated intervention on all risk factors , reducing blood pressure to below 140/80 mmHg , low - density lipoprotein cholesterol ( LDL - c ) to below 100 mg / dl , encouraging smoking cessation , regular physical activity and maintaining a healthy weight ( BMI & lt ; 25 kg / m2 ) . - pubmed
In secondary prevention or persons with microvascular disease , the targets may be stricter ( blood pressure 130/80 mmHg and LDL - c 80 mg / dl ) . - pubmed
IL-18R protein expression was higher on alveolar macrophages in lung tissue of COPD patients ( mean 23.2 % ) compared to controls ( mean ex - smokers 2 % and non - smokers 2.5 % ) . - pubmed
The replication by PCR and protein in different studies confirms these findings , and highlights a potential role for IL-18R upregulation in severe COPD . - pubmed
CONCLUSIONS AND IMPLICATIONS : The present findings suggest that antenatal nicotine exposure results in the programming of heightened oxidative stress and vascular hypertensive reactivity via a Nox2 - dependent mechanism , leading to an increased risk of hypertension in adult offspring . - pubmed
Increased neuronal nitric oxide synthase dimerisation is involved in rat and human pancreatic beta cell hyperactivity in obesity . - pubmed
AIMS / HYPOTHESIS : Pancreatic beta cell hyperactivity is known to occur in obesity , particularly in insulin - resistant states . - pubmed
Our aim was to investigate whether changes in neuronal nitric oxide synthase ( nNOS ) function affect beta cell compensation in two relevant models : the Zucker fa / fa rats and pancreatic islets from obese humans . - pubmed
METHODS : Glucose - induced insulin response was evaluated in the isolated perfused rat pancreas and in human pancreatic islets from obese individuals . - pubmed
Pharmacological blockade of nNOS was unable to modify beta cell response to glucose in fa / fa rats and in islets from obese individuals , suggesting an abnormal control of insulin secretion by the enzyme . - pubmed
CONCLUSIONS / INTERPRETATION : Increased nNOS production and dimerisation , together with a relative decrease in catalytic activity and relocalisation , are involved in beta cell hyperactivity in insulin - resistant rats but also in human islets isolated from obese individuals . - pubmed
A hallmark of immunity to acute infection is the production of gamma interferon ( IFN - gamma ) and interleukin-12 ( IL-12 ) , followed by a protective T cell response that is critical for parasite control . - pubmed
Contribution of matrix metalloproteinase-9 to cerebral edema and functional outcome following experimental subarachnoid hemorrhage . - pubmed
Matrix metalloproteinase ( MMP )- 9 is held responsible for the degradation of microvascular basal lamina proteins leading to blood - brain barrier dysfunction and , thus , formation of vasogenic cerebral edema . - pubmed
The current study was conducted to clarify the role of MMP-9 for the development of cerebral edema and for functional outcome after SAH . - pubmed
METHODS : SAH was induced in FVB / N wild - type ( WT ) or MMP-9 knockout ( MMP-9(-/- ) ) mice by endovascular puncture . - pubmed
MMP-9(-/- ) mice also exhibited better neurological recovery , less brain edema formation , and lower chronic ICP . - pubmed
CONCLUSIONS : The results of the current study suggest that MMP-9 contributes to the development of early brain damage after SAH by promoting cerebral edema formation . - pubmed
Hence , MMP - 9 may represent a novel molecular target for the treatment of SAH . - pubmed
CONCLUSION : It seems that neither improvement in imaging results nor CA-125 level response can predict the survival of ovarian carcinoma patients prior to interval debulking after neoadjuvant chemotherapy . - pubmed
The use of immunosuppressant medications and biologics such as tumor necrosis factor alpha antagonists has revolutionized the treatment of inflammatory bowel disease . - pubmed
Novel nonsense mutation in MSX1 causes tooth agenesis with cleft lip in a Chinese family . - pubmed
Previous studies have attributed non - syndromic tooth agenesis to mutations in several genes , including MSX1 , PAX9 , EDA , and AXIN2 . - pubmed
Our findings suggest that the nonsense mutation in MSX1 might have resulted in rapid degradation of the mutated transcript and caused the phenotype of tooth agenesis with cleft lip in the Chinese family . - pubmed
Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor - beta type II receptor . - pubmed
Accumulating evidence suggests that transforming growth factor ( TGF )- beta1 promotes the development of renal fibrosis . - pubmed
Heat shock protein ( Hsp ) 90 inhibitors have been shown to repress TGF - beta1 signaling , but whether they inhibit renal fibrosis is unknown . - pubmed
The purpose of this study is to determine the therapeutic efficacy of Hsp90 inhibitor on renal fibrosis . - pubmed
In TGF - beta1 - treated HK2 cells and unilateral ureteral obstruction ( UUO ) kidneys , we found that 17 - allylamino-17 - demethoxygeldanamycin ( 17AAG ) , an Hsp90 inhibitor , decreased the expression of alpha - smooth muscle actin , fibronectin , and collagen I and largely restored the expression of E - cadherin . - pubmed
The effect of 17AAG on TbetaRII expression and renal fibrosis was confirmed in UUO kidneys . - pubmed
These findings suggest that Hsp90 inhibitor prevents the development of renal fibrosis via a mechanism dependent on Smurf2 - mediated degradation of TbetaRII . - pubmed
Aromatase inhibitor ( AI ) therapy for breast cancer provides an ideal paradigm for studying this issue , because AIs have been the focus of substantial DTCA , and because they should only be used in postmenopausal women , age can serve as a simple surrogate marker of appropriateness . - pubmed
KRAS mutation analysis on low percentage of colon cancer cells : the importance of quality assurance . - pubmed
KRAS mutation testing is mandatory for patients with metastatic colorectal cancer who are eligible for treatment with an epidermal growth factor receptor targeting agent , since tumors with a mutation are not sensitive to the drug . - pubmed
Toll - like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4 . - pubmed
APPROACH AND RESULTS : Type 2 diabetic mice with mutated toll - like receptor 4 ( DWM ) were protected from hyperglycemia and hypertension , despite an increased body weight . - pubmed
The in vivo and in vitro administration of lipopolysaccharide caused endothelial dysfunction in the arteries of wild - type , but not toll - like receptor 4 - mutated mice . - pubmed
CONCLUSIONS : Toll - like receptor 4 plays a key role in obesity and diabetes - associated endothelial dysfunction by increasing oxidative stress . - pubmed
Granulocyte - colony stimulating factors ( G - CSFs ) enhance bone marrow ( BM ) recovery after autologous stem cell transplant ( ASCT ) in patients with lymphoma and myeloma . - pubmed
Autocrine human growth hormone increases sensitivity of mammary carcinoma cell to arsenic trioxide - induced apoptosis . - pubmed
Human growth hormone ( hGH ) has been increasingly implicated in a variety of cancers ; its up - regulation is observed in breast cancer and correlates with a poor outcome . - pubmed
Autocrine hGH promotes mammary carcinoma cell survival , proliferation , immortalization ; it confers an invasive phenotype as a result of an epithelial - mesenchymal transition and contributes to chemoresistance and radioresistance . - pubmed
In the present study , we investigated the effect of hGH on sensitivity of a mammary adenocarcinoma cell to ATO , using a stable hGH - transfectant MCF-7 cell line , MCF7 - hGH . - pubmed
Our results demonstrated for the first time that the overexpression of hGH increased sensitivity of the breast cancer cell line MCF-7 to ATO through apoptotic and anti - proliferative mechanisms . - pubmed
Our study may highlight the potential application of ATO for the treatment of patients with breast cancer , especially in those who have metastatic and chemoresistant tumor phenotype possibly due to the over expression of hGH . - pubmed
In the present study , we investigated the possible role of the dorsal hippocampal ( CA1 ) dopamine D1 receptors on scopolamine - induced amnesia as well as scopolamine state - dependent memory in adult male Wistar rats . - pubmed
Similarly , the pre - test administration of dopamine D1 receptor agonist , 1 - phenyl-7,8 - dihydroxy-2,3,4,5 - tetrahydro-1H-3 - benzazepine hydrochloride ( SKF38393 ; 1 , 2 and 4 mug / rat , intra - CA1 ) , could significantly reverse the scopolamine - induced amnesia . - pubmed
Moreover , while the pre - test intra - CA1 injection of the dopamine D1 receptor antagonist , R (+)- 7 - chloro-8 - hydroxy-3 - methyl-1 - phenyl-2,3,4,5 - tetrahydro-1H-3 - benzazepine hydrochloride ( SCH23390 ; 0.1 and 0.5 mug / rat , intra - CA1 ) , resulted in apparent memory impairment , microinjection of the same doses of this agent inhibited the scopolamine - induced state - dependent memory . - pubmed
These results indicate that the CA1 dopamine D1 receptors may potentially play an important role in scopolamine - induced amnesia as well as the scopolamine state - dependent memory . - pubmed
Furthermore , our results propose that dopamine D1 receptor agonist , SKF38393 reverses the scopolamine - induced amnesia via acetylcholine release and possibly through the activation of muscarinic receptors . - pubmed
Alpha-1 - adrenergic receptors in heart failure : the adaptive arm of the cardiac response to chronic catecholamine stimulation . - pubmed
There are far fewer alpha-1 - ARs than beta - ARs in the nonfailing heart , but their abundance is maintained or increased in the setting of heart failure , which is characterized by pronounced chronic elevation of catecholamines and beta - AR dysfunction . - pubmed
Decades of evidence from gain and loss - of - function studies in isolated cardiac myocytes and numerous animal models demonstrate important adaptive functions for cardiac alpha-1 - ARs to include physiological hypertrophy , positive inotropy , ischemic preconditioning , and protection from cell death . - pubmed
Clinical trial data indicate that blocking alpha-1 - ARs is associated with incident heart failure in patients with hypertension . - pubmed
Collectively , these findings suggest that alpha-1 - AR activation might mitigate the well - recognized toxic effects of beta - ARs in the hyperadrenergic setting of chronic heart failure . - pubmed
Thus , exogenous cardioselective activation of alpha-1 - ARs might represent a novel and viable approach to the treatment of heart failure . - pubmed
We proceed by discussing recently described functions of Mia40 in the hypoxia response and of ALR in influencing mitochondrial morphology and its importance for tissue development and embryogenesis . - pubmed
The human TDE2 / Serinc1 gene was cloned by our laboratory during the screening for differentially expressed genes in hepatocarcinoma . - pubmed
In the present study , we knocked down the expression of TDE2 with specific siRNA fragments in two human hepatocarcinoma cell lines , and this caused cell cycle arrest at G2 . - pubmed
In conclusion , our preliminary results indicated that TDE2 may have an effect on tumor cell growth by influencing the expression of SREBP and p21 . - pubmed
OBJECTIVE : To evaluate whether administration of goserelin , a gonadotropin - releasing hormone ( GnRH ) agonist , could prevent acute or chronic ovarian insufficiency from cyclophosphamide ( CTX ) administration to prepubertal mice . - pubmed
Changes in plasma levels of B - type natriuretic peptide with acute exacerbations of chronic obstructive pulmonary disease . - pubmed
BACKGROUND : Elevated plasma B - type natriuretic peptide ( BNP ) levels and their association with heart failure have been reported in subjects with acute exacerbations of chronic obstructive pulmonary disease ( AECOPD ) . - pubmed
PURPOSE : To examine and compare plasma BNP levels and diastolic and systolic dysfunction in subjects with AECOPD and stable chronic obstructive pulmonary disease ( COPD ) . - pubmed
RESULTS : In the hospitalized subjects , the median plasma BNP level ( interquartile range ) was 55.4 ( 26.9 - 129.3 ) pg / mL and was higher than that of patients with stable COPD : 18.3 ( 10.0 - 45.3 ) for Global Initiative for Chronic Obstructive Lung Disease grade I ; 25.8 ( 11.0 - 53.7 ) for grade II ; 22.1 ( 9.1 - 52.6 ) for grade III ; and 17.2 ( 9.6 - 22.9 ) pg / mL for grade I V , all P<0.001 . - pubmed
In 15 subjects studied prospectively , the median plasma BNP level was 19.4 ( 9.8 - 32.2 ) pg / mL before AECOPD , 72.7 ( 27.7 - 146.3 ) pg / mL during AECOPD , and 14.6 ( 12.9 - 39.0 ) pg / mL after AECOPD ( P<0.0033 and P<0.0013 , respectively ) . - pubmed
Median plasma BNP levels during AECOPD were significantly higher in ten unsuccessfully discharged subjects 260.5 ( 59.4 - 555.0 ) than in 48 successfully discharged subjects 48.5 ( 24.2 - 104.0 ) pg / mL ( P=0.0066 ) . - pubmed
CONCLUSION : A modest elevation of plasma BNP is observed during AECOPD . - pubmed
It appears that AECOPD may have an impact on plasma BNP levels that is not attributable to heart failure . - pubmed
CD44v8 - 10 is a cancer - specific marker for gastric cancer stem cells . - pubmed
The surface marker CD44 has been identified as one of several markers associated with cancer stem cells ( CSC ) in solid tumors , but its ubiquitous expression in many cell types , including hematopoietic cells , has hindered its use in targeting CSCs . - pubmed
Cells that expressed pan - CD44 were found to occur at significantly higher frequency in gastric tumor tissues . - pubmed
We identified CD44v8 - 10 as the predominant CD44 variant expressed in gastric cancer cells and verified its role as a gastric CSC marker by limiting dilution and serial transplantation assays . - pubmed
Analyses of another 26 primary samples showed significant CD44v8 - 10 upregulation in gastric tumor sites . - pubmed
Exogenous expression of CD44v8 - 10 but not CD44 standard ( CD44s ) increased the frequency of tumor initiation in immunocompromised mice . - pubmed
Reciprocal silencing of total CD44 resulted in reduced tumor - initiating potential of gastric cancer cells that could be rescued by CD44v8 - 10 but not CD44s expression . - pubmed
Our findings provide important functional evidence that CD44v8 - 10 marks human gastric CSCs and contributes to tumor initiation , possibly through enhancing oxidative stress defense . - pubmed
In addition , we showed that CD44v8 - 10 expression is low in normal tissues . - pubmed
Because CD44 also marks CSCs of numerous human cancers , many of which may also overexpress CD44v8 - 10 , CD44v8 - 10 may provide an avenue to target CSCs in other human cancers . - pubmed
Platelet - derived exosomes suppressed ex vivo platelet aggregation and reduced adhesion to collagen - coated microfluidic channels at high shear . - pubmed
CONCLUSIONS : Platelet - derived exosomes inhibit athero - thrombotic processes by reducing CD36 - dependent lipid loading of macrophages and by suppressing platelet thrombosis . - pubmed
The genetic cause of CdLS is a mutation in one of five associated genes ( NIPBL , SMC1A , SMC3 , RAD21 , and HDAC8 ) accounting for about 70 % of cases . - pubmed
Because recent data indicate a high frequency of mosaic NIPBL mutations that were not detected by conventional sequencing approaches of blood DNA , we started to collect buccal mucosa ( BM ) samples of our patients that were negative for mutations in the known CdLS genes . - pubmed
BDNF blood levels after non - invasive brain stimulation interventions in major depressive disorder : a systematic review and meta - analysis . - pubmed
We included trials published in PubMed / Medline from the first date available to June 2014 measuring BDNF blood levels before and after repetitive transcranial magnetic stimulation or transcranial direct current stimulation in depression . - pubmed
CONCLUSIONS : Peripheral BDNF levels do not increase after NIBS in depression . - pubmed
Increased serum concentrations of adiponectin in canine hypothyroidism . - pubmed
Serum concentrations of adiponectin were compared between sex - matched hypothyroid ( n = 18 ) and euthyroid ( n = 18 ) client - owned dogs with comparable ages and body condition scores ( BCS ) . - pubmed
Concentrations of adiponectin ( mean ; 95 % confidence interval ) were significantly ( P & lt ; 0.01 ) higher in hypothyroid ( 17.2 microg / mL ; 12.1 - 20.5 microg / mL ) than healthy ( 8.0 microg / mL ; 5.6 - 11.4 microg / mL ) dogs following adjustment for potential confounders ( BCS , age and sex ) . - pubmed
Serum concentrations of adiponectin were significantly negatively associated with concentrations of total thyroxine ( P & lt;0.05 ) and positively correlated with concentrations of cholesterol ( r = 0.6 , P & lt;0.01 ) in hypothyroid dogs . - pubmed
In conclusion , this study demonstrated increased serum concentrations of adiponectin in dogs with hypothyroidism . - pubmed
Suggestive of the presence of resistance to adiponectin that could have contributed to development of hyperlipidemia and insulin resistance in these dogs or alternatively , could be a consequence of these metabolic alterations . - pubmed
A quadriceps muscle biopsy revealed a chronic inflammatory myopathy with ubiquitinated inclusion bodies , rimmed vacuoles , expression of major histocompatibility complex class I , numerous COX - negative fibers and TDP-43 cytoplasmic aggregates ( features of IBM ) and multiple non - necrotizing granulomata ( feature of sarcoidosis ) . - pubmed
Because Erk1 / 2 and Akt activation has been linked to tamoxifen - related anti - estrogen resistance in breast cancer patients , these results indicate that omega-3FFA may interfere with the effects of tamoxifen in the prevention of breast cancer risk . - pubmed
The PLR was found to be significantly positively correlated with CA125 serum level , tumor - node - metastasis ( TNM ) stage , and tumor differentiation . - pubmed
Univariate analysis identified carcinoembryonic antigen ( CEA ) , CA125 and CA199 levels , PLR , TNM stage , and the degree of differentiation as significant prognostic factors for GBC when they were expressed as binary data . - pubmed
Multivariate analysis showed that CA125 & gt ; 35 U / mL , CA199 & gt ; 39 U / mL , PLR & gt;= 117.7 , and TNM stage IV were independently associated with poor survival in GBC . - pubmed
Significance of EGFR signaling pathway genetic alterations in radically resected non - small cell lung cancers from a Polish cohort . - pubmed
PURPOSE : We evaluated the distribution and clinical impact of EGFR , KRAS and HER2 copy number gains and EGFR , KRAS and BRAF activating mutations in resected non - small cell lung cancers ( NSCLCs ) from 151 Polish patients . - pubmed
RESULTS : An increased EGFR CN was found in 21.2 % of the tumors , more commonly of the non - squamous histology ( P=0.029 ) , larger in size ( P=0.004 ) and those obtained from women ( P=0.040 ) . - pubmed
HER2 copy gain was observed in 21.8 % of the patients , more frequently with lymph node metastases ( P=0.048 ) and stage IIIA disease ( P=0.061 ) . - pubmed
KRAS gain was found in 29.3 % of the tumors , and was not associated with patients ' clinicopathological features . - pubmed
EGFR and KRAS mutation frequency and associations with clinicopathological characteristics did not differ significantly from those previously described for the NSCLC patients of Caucasian ethnicity . - pubmed
In the multivariate model , EGFR mutations constituted an independent prognostic factor of the disease recurrence in adenocarcinoma patients ( HR 7.20 ; 95%CI 1.31 - 39.48 ; P=0.023 ) , while an increased EGFR copy number tended to indicate a shorter overall survival ( HR 4.85 ; 95%CI 0.92 - 25.58 ; P=0.062 ) . - pubmed
CONCLUSIONS : EGFR pathway genes alterations are frequent in NSCLCs from Polish patients and have a prognostic potential for patients ' clinical outcome after a curative tumor resection . - pubmed
Herein , we focused on the ganglioside GM2 tumor - associated carbohydrate antigen ( TACA ) , which is overexpressed in a wide range of tumor cells . - pubmed
In contrast , GM2 immobilized on Qbeta through a thiourea linker elicited high titers of IgG antibodies that recognized GM2 - positive tumor cells and effectively induced cell lysis through complement - mediated cytotoxicity . - pubmed
TBMS1 exerts its cytotoxicity in NCI - H460 lung cancer cells through nucleolar stress - induced p53 / MDM2 - dependent mechanism , a quantitative proteomics study . - pubmed
Tubeimoside-1 ( TBMS1 ) exerts its anticancer effects by inducing G2 / M arrest and apoptosis of cancer cells . - pubmed
Functional validation demonstrated that TBMS1 - induced NCI - H460 cell cytotoxicity involved nucleolar stress - induced p53 / murine double minute clone 2 ( MDM2 ) , mTOR , and NF - kappaB signaling pathways . - pubmed
Mutations in the CBS gene cause clinical CBS deficiency , a disease characterized by elevated plasma total homocysteine ( tHcy ) and methionine and decreased plasma cysteine . - pubmed
RESULTS : The messenger RNA ( mRNA ) expression of the inflammatory cytokines interleukin-1 beta ( IL-1beta ) and IL-8 and of matrix metalloproteinase ( MMP )- 3 ( a catabolic gene ) in both the synovium and the labrum , and the expression of collagen type I alpha 1 ( an anabolic gene ) in the labrum , was higher in the samples from hips with OA than in those from hips with FAI ( p & lt ; 0.05 ) . - pubmed
In cartilage , however , the mRNA expression of the inflammatory cytokines and the catabolic genes MMP-13 and ADAMTS-4 ( a disintegrin and metalloproteinase with thrombospondin motifs-4 ) was higher in the FAI samples compared with the OA samples ( p & lt ; 0.01 ) . - pubmed
When the expression of inflammatory cytokines was evaluated among the three types of tissues within each disease group , the expression levels were the highest in cartilage within the FAI samples ( p & lt ; 0.01 ) . - pubmed
In FAI cartilage , we found higher gene expression of aggrecan ( ACAN ) and ADAMTS-4 in the samples from patients with larger alpha angles ( & gt;=60 ) ( p & lt ; 0.01 ) . - pubmed
Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus . - pubmed
In women with GDM ( 8.3 % ) , defects in insulin sensitivity or secretion were defined below the 25th percentile in women with normal glucose tolerance ( NGT ) . - pubmed
While the general mechanism underlying this observation is deficient CD4+T - cell function , it is unknown whether increased severity of herpes virus infections is due primarily to poor immune control in latent or lytic sites of infection , or whether CD4 + immunodeficiency leads to more critical downstream deficits in humoral or cell - mediated immunologic responses . - pubmed
TL was used to determine the effects of iron deficiency on photosystem II ( PSII ) activity . - pubmed
The effect of iron deficiency on the photosystem I ( PSI ) activity was also examined by measuring the changes in P700 redox state during illumination . - pubmed
The results of this work suggest that iron deficiency induces partial blocking of the electron transfer between PSII and PSI , due to a lower concentration of the electron donor cytochrome c 6 . - pubmed
Preoperative Hemoglobin A1c and the Occurrence of Atrial Fibrillation Following On - pump Coronary Artery Bypass Surgery in Type-2 Diabetic Patients . - pubmed
BACKGROUND : We investigated the association of the preoperative hemoglobin A1c ( HbA1c ) with occurrence of postoperative atrial fibrillation ( POAF ) in type-2 diabetic patients who underwent isolated coronary artery bypass grafting . - pubmed
CONCLUSIONS : Serum level of HbA1c could not be used as a predictor for the development of POAF . - pubmed
The Janus tyrosine kinase 2 mutation can be used as a key diagnostic tool for diagnosing MPDs , specifically , ET , PV , and PMF . - pubmed
Our observation may explain why some viruses responsible for virological failure in patients treated with dolutegravir did not show mutations in the integrase gene . - pubmed
HLA - B*52:01 - C*12:02 , which is found in approximately 20 % of all Japanese persons , is well known to be associated with ulcerative colitis and Takayasu arteritis . - pubmed
Association of Lipoprotein ( a ) With Risk of Recurrent Ischemic Events Following Acute Coronary Syndrome : Analysis of the dal - Outcomes Randomized Clinical Trial . - pubmed
Importance : It is uncertain whether lipoprotein ( a ) [ Lp ( a ) ] , which is associated with incident cardiovascular disease , is an independent risk factor for recurrent cardiovascular events after acute coronary syndrome ( ACS ) . - pubmed
Objective : To determine the association of Lp ( a ) concentration measured after ACS with the subsequent risk of ischemic cardiovascular events . - pubmed
Conclusions and Relevance : For patients with recent ACS who are treated with statins , Lp ( a ) concentration was not associated with adverse cardiovascular outcomes . - pubmed
These findings call into question whether treatment specifically targeted to reduce Lp ( a ) levels would thereby lower the risk for ischemic cardiovascular events after ACS . - pubmed
The Abeta1 - 42 dimer is the smallest oligomer of the 42 - residue Abeta peptide ( Abeta1 - 42 ) , which is involved in Alzheimer ' s disease . - pubmed
Unilateral IGF-1 injection for mandibular asymmetry . - pubmed
Elevation of antimullerian hormone in women with polycystic ovary syndrome undergoing assisted reproduction : effect of insulin . - pubmed
OBJECTIVE : To measure blood and follicular antimullerian hormone ( AMH ) levels in women with polycystic ovary syndrome ( PCOS ) undergoing assisted reproductive technologies ( ART ) and to examine the direct action of insulin on AMH expression in human granulosa cells . - pubmed
RESULT(S ): Serum levels of AMH were elevated and inversely correlated with embryo cleavage rate in PCOS women in ART . - pubmed
Significant higher levels of AMH were also found in small and large follicles collected from PCOS women compared with non - PCOS women . - pubmed
Luteinized granulosa cells from PCOS women showed higher expression of AMH and its receptor AMHR2 . - pubmed
Direct effect of insulin in increasing the expression of AMH in the isolated luteinized granulosa cells was observed , with the PCOS granulosa cells responding to a high dose of insulin . - pubmed
CONCLUSION(S ): These results suggest that insulin may contribute to AMH elevation in PCOS and that AMH counteracts insulin - promoted aromatase expression in granulosa cells . - pubmed
The discovery that women in endemic regions develop a certain immunity against VAR2CSA - expressing parasites with increasing number of pregnancies has redefined the understanding of malaria in pregnancy and offers strategies for the development of vaccines . - pubmed
RESULTS : A decrease in the frequency of ARVI in patients with CHF treated with Amixin was found , which was accompanied by a decrease in the severity of subclinical inflammation by reducing the production of proinflammatory ( IL-1beta ) and increasing the production of anti - inflammatory ( IL-10 ) cytokines , reducing neurohumoral activation ( reducing levels of aldosterone and Nt - proBNP ) , increasing the level of alpha - and gamma - interferon . - pubmed
NLRP3 inflammasome expression in peripheral blood monocytes of coronary heart disease patients and its modulation by rosuvastatin . - pubmed
The present study aimed to determine the expression of NLRP3 inflammasome in peripheral blood monocytes ( PBMCs ) of stable angina pectoris ( SAP ) and acute myocardial infarction ( AMI ) patients . - pubmed
NLRP3 inflammasome was expressed in the PBMCs , and revealed an increased expression along the downstream interleukin ( IL )- 1beta and IL-18 in both SAP and AMI groups , compared to the control group . - pubmed
Interference with rosuvastatin in vitro revealed that the expression of NLRP3 inflammasome and its downstream cytokines were significantly downregulated in both SAP and AMI groups in a time - dependent manner . - pubmed
The activation of NLRP3 inflammasome may be involved in the development of CHD , and rosuvastatin could attenuate the inflammatory process of atherosclerosis by downregulating NLRP3 expression and its downstream mediators . - pubmed
These findings indicated a potential role of NLRP3 in the pathogenesis and management of CHD , and also provided new insights into the mechanistic framework of rosuvastatin activity . - pubmed
Heme Oxygenase Upregulation in Obesity and the Metabolic Syndrome . - pubmed
CRITICAL ISSUES : Heme Oxygenase plays an ever increasing role in the understanding of human biology in the fields of obesity and the metabolic syndrome . - pubmed
miR-30b-3p Inhibits Proliferation and Invasion of Hepatocellular Carcinoma Cells via Suppressing PI3K / Akt Pathway . - pubmed
TRIM27 was demonstrated to have an oncogenic role in HCC cells by enhancing cell viability , proliferation , migration , and invasion . - pubmed
Finally , the miR-30 - 3p - TRIM27 - PI3K / Akt axis was shown to play a crucial role in HCC cells in vitro . - pubmed
Objective : In this study , we investigated the antitumor activity of interleukin ( IL )- 18 on A549 human lung cancer cell line and evaluated the potential of IL-18 therapy in lung cancer . - pubmed
Conclusion : Using a lentiviral expression vector , IL-18 was expressed stably and efficiently in A549 cells , which showed attenuated proliferation and tumor cell growth , and enhanced tumor cell apoptosis . - pubmed
These findings further demonstrated the antitumor activity of IL-18 and might open new therapeutic avenues for the prevention and treatment of lung cancer . - pubmed
A triplet repeat expansion leading to transcriptional silencing of the FMR1 gene results in fragile X syndrome ( FXS ) , which is a common cause of inherited intellectual disability and autism . - pubmed
Regulation of miR-125a has been associated with type I metabotropic glutamate receptor signaling ( mGluR ) , which has been explored as a treatment target for FXS , reinforcing the possibility that urine miR-125a may provide a novel biomarker for FXS . - pubmed
KEGG enrichment analysis found that cortisol regulated LPS - stimulated immune responses mainly focus on cytokines , complement and coagulation cascades pathways , antigen presentation pathways , haematopoiesis , and inflammation . - pubmed
[ Pharmaco - resistance and side effects of antipsychotics associated with poor metabolizer phenotype for cytochrome P450 2D6 in a context of early - onset schizophrenia : A case report ] . - pubmed
We measured microvascular dysfunction at baseline by use of flicker light - induced retinal vessel dilation response ( Dynamic Vessel Analyzer ) , heat - induced skin hyperemic response ( laser- Doppler flowmetry ) , and plasma markers of endothelial dysfunction ( endothelial dysfunction ; sICAM-1 [ soluble intercellular adhesion molecule-1 ] , sVCAM-1 [ soluble vascular adhesion molecule-1 ] , sE - selectin [ soluble E - selectin ] , and vWF [ Von Willebrand Factor ] ) . - pubmed
LncRNA HOTAIR - mediated MTHFR methylation inhibits 5 - fluorouracil sensitivity in esophageal cancer cells . - pubmed
RESULTS : We found reciprocal expression patterns of lncRNA HOTAIR and MTHFR in EC tissues and human EC cells . - pubmed
Interference with lncRNA HOTAIR enhanced 5 - FU - induced apoptosis , exhibited anti - proliferative activity , and reduced promoter methylation of the MTHFR in EC cells . - pubmed
Besides , overexpression of MTHFR attenuated the acquired chemoresistance induced by overexpression of lncRNA HOTAIR in EC cells . - pubmed
CONCLUSION : Together , our study proposes that pharmacologic targeting of lncRNA HOTAIR sensitizes EC cells to 5 - FU - based chemotherapy by attenuating the promoter hypermethylation of the MTHFR in EC . - pubmed
Roles of follicle stimulating hormone and its receptor in human metabolic diseases and cancer . - pubmed
Follicle stimulating hormone ( FSH ) and its receptor ( FSHR ) play an important role in human metabolic diseases and cancer . - pubmed
Evidence showed that FSHR is not only distributed in ovary and testis but also in other cells or organs such as osteoclast , adipocytes , liver , pituitary cancer and so forth . - pubmed
Moreover , FSH is associated with lipogenesis , inflammation , insulin sensitivity , thermogenesis , skeletal metabolism , osteogenesis and ovarian cancer , all of which have been confirmed closely related to metabolic diseases or metabolic - related cancer . - pubmed
Therefore , FSH and FSHR may be potential therapeutic targets for metabolic diseases and metabolic - related cancer . - pubmed
Epidemiological researches revealed close relationship between FSH / FSHR and metabolic diseases or cancer . - pubmed
We reviewed the recent researches and present an integrated framework of FSH / FSHR and metabolic diseases and cancer , which provides potential targets for the treatments of metabolic diseases and cancer . - pubmed
Common causes of death in COVID-19 due to SARS - CoV-2 include thromboembolic disease , cytokine storm and adult respiratory distress syndrome ( ARDS ) . - pubmed
An attempt was made to identify predictive elements for thromboembolism , cytokine storm and ARDS based on physiological measurements and blood tests , and to communicate to clinicians managing the patient , initially via single consultants . - pubmed
Thromboembolism and cytokine storm flags were met in the ED for 342 ( 37.1 % ) patients . - pubmed
YAP increases response to Trastuzumab in HER2 - positive Breast Cancer by enhancing P73 - induced apoptosis . - pubmed
The role of the Yes - associated protein ( YAP ) in oncogenesis and progression of breast cancer remains controversial . - pubmed
Meanwhile , development of therapeutic resistance to trastuzumab , a common breast cancer treatment administered after chemotherapy , is a significant challenge in the treatment of HER2 - positive breast cancer . - pubmed
We , therefore , analyzed the role of YAP in trastuzumab resistance in HER2 - positive - breast carcinoma cells in vitro and evaluated the status of YAP and related proteins in patient - derived breast carcinoma tissues by immunohistochemistry . - pubmed
Our results show that YAP is involved in trastuzumab resistance in HER2 - positive breast carcinoma cells and that YAP and AKT may be developed as prognostic markers of neoadjuvant trastuzumab therapy in patients with HER2 - positive breast cancer . - pubmed
CD34 + , CD45 + , white blood cell , and lymphocyte counts decreased , with the lowest levels also observed at EOT ( P < .001 ) . - pubmed
Fatigue and insomnia were associated with changes in both interferon gamma - induced protein 10 ( IP-10 ) - ( P = .03 and P = .01 , respectively ) and tumor necrosis factor receptor II ( TNF - RII ) ( P = .02 and P = .006 , respectively ) , while mental fatigue was associated with increased matrix metalloproteinases-2 ( MMP-2 ) levels ( P = .03 ) . - pubmed
Conclusions : This is the first longitudinal study to examine linkages between symptoms , HSCs , and cytokines , demonstrating that fatigue and insomnia shared associations with increasing serum levels of IP-10 and TNF - RII , and mental fatigue was associated with increasing serum levels of MMP-2 . - pubmed
Mice experiment also showed that curcumol could alleviate chronic liver injury by reducing KLF5 expression . - pubmed
SIGNIFICANCE : We suggested that transcription factor KLF5 could be considered as a new target molecule of curcumol in improving liver fibrosis , and pointed out that curcumol targeted ROS / ERK - mediated KLF5 expression could inhibit LSEC angiogenesis . - pubmed
ANRIL has a convincing potential to be used as an additive therapeutic tool in TAA and AAA . - pubmed
[ Effects of propranolol on plasma lipids and renin activity in young men with labile borderline hypertension ( author 's transl ) ] . - pubmed
In our two cases ( and in one of the previous cases ) , the syndrome was preceded by a sudden increase in the amount of serum immunoglobulin M antibody to cytomegalovirus . - pubmed
Platelet 5 - HT2 serotonin receptor binding sites in autistic children and their first - degree relatives . - pubmed
We examined platelet serotonin2 [ 5 - hydroxytryptamine2 ( 5 - HT2 ) ] receptor binding sites , whole blood serotonin ( 5 - HT ) , and plasma norepinephrine ( NE ) in male autistic children and their first - degree relatives . - pubmed
[ Changes in the dietary regimen during treatment of type I diabetes mellitus with continuous insulin infusion . - pubmed
UNLABELLED : The authors investigated in 11 type diabetics the effect of omission of a meal on the compensation of diabetes during treatment with an insulin pump IP 1003 . - pubmed
Several lines of evidence indicate that neutrophil elastase and oxidants secreted by phagocytic inflammatory cells play key roles in the development of centrilobular emphysema . - pubmed
In follow - up studies of 10 patients admitted for acute alcoholism , elastase activity and superoxide production remained low for 2 to 4 days . - pubmed
Production of monoclonal antibody to thyroglobulin from malignant thyroid carcinoma . - pubmed
In this study , the production of anti - human thyroglobulin ( Tg ) monoclonal antibodies was attempted to detect Tg levels in serum and to study the localization of thyroid metastases in patients with thyroid - gland ablation . - pubmed
Our monoclonal antibody , 2G4 , will be a hopeful reagent for the diagnosis in thyroid carcinoma . - pubmed
Beta 2 - adrenoceptor responsiveness of the airways after inhaled adenosine and histamine was further studied in 12 asthmatic subjects by observing the antibronchoconstrictor effect of inhaled isoproterenol . - pubmed
Arylsulfatase A and B activities have been determined in urine samples from four patients who received a Kidney allograft from living donors as a treatment for terminal uraemia . - pubmed
Dose - response studies of mitogen stimulation with phytohemagglutinin and concanavalin A revealed generally higher proliferative responses in the psoriatic patients only at supraoptimal concentrations . - pubmed
Patients with PSR had significantly higher mean cell haemoglobin and lower Hb F levels on average than the matched controls , but the viscosity and erythrocyte filtration indices did not differ between the 2 groups . - pubmed
Since aspartic acid is a putative excitatory neurotransmitter , a possible causal relationship is suggested between its increased CSF concentration and the occurrence of neonatal convulsions in this family . - pubmed
Selective alpha-1 blockers seem to be useful in patients with uncomplicated benign prostatic hyperplasia and mild to moderate symptoms . - pubmed
Superoxide dismutase activities and mRNA levels were not affected by hyperoxia , whereas catalase activity was slightly decreased after 24 h in 80 % oxygen at Day 17 . - pubmed
Glutathione peroxidase activity was markedly decreased already after 12 h of hyperoxia , and decreased activities of glutathione reductase and glucose-6 - phosphate dehydrogenase were also noted . - pubmed
To determine if Muerto Canyon Virus ( MCV ) RNA is present in the peripheral blood of patients with hantavirus pulmonary syndrome , a reverse transcriptase - polymerase chain reaction ( RT - PCR ) assay for MCV RNA was used on blood samples from 20 seropositive case - patients . - pubmed
The presence of mGluR1 alpha in cells of the hippocampus that are associated with the release of somatostatin , suggest that this receptor could play a role in regulating hippocampal excitability in both normal and epileptic tissues . - pubmed
Collagen synthesis in intact skin is suppressed during wound healing . - pubmed
OBJECTIVE : Simultaneous monitoring of total collagen synthesis as well as synthesis in intact skin and in the wound to verify the higher priority of wound healing after surgery . - pubmed
The authors hypothesized a lower priority in synthesis of structural and peripheral collagen for the benefit of wound healing . - pubmed
CONCLUSIONS : Collagen synthesis is regulated for the benefit of the wound during the acute phase response . - pubmed
High molecular weight phospholipase A2 and fatty acids in human colon tumours and associated normal tissue . - pubmed
Compared with normal mucosa / submucosa , there was more total arachidonate in tumours ( P & lt ; 0.01 ) , and increased levels of cPLA2 occurred in 6 of 17 tumours . - pubmed
In conclusion , the higher amounts of tumour total arachidonate and the sometimes higher levels of cPLA2 , might help to explain why some human colon tumours form increased amounts of PGs . - pubmed
Most cases are associated with X - linked Alport syndrome and have partial deletions in the genes encoding both the alpha5 and alpha6 chains of collagen type IV . - pubmed
In DL , a primary abnormality of basement membrane may be associated with disorganization of the contractile apparatus and alterations of certain integrins . - pubmed
We assessed the anticoagulant effects of acenocoumarol with INR , factors VII and X and protein C in 12 randomly selected hospitalised patients with deep - vein thrombosis , six of them receiving a daily dose of acenocoumarol , the other six receiving twice daily doses . - pubmed
The CCl4 administration alone caused hepatocellular necrosis , severe anemia , leucopaenia , lymphocytopaenia , neutrophilia , eosinophilia and haemoglobinaemia along with the alterations of plasma albumin and globulin . - pubmed
Thyroid peroxidase ( TPO ) as a tumor marker in the follow - up of differentiated thyroid carcinomas with surgical and ablative radioiodine therapy . - pubmed
The clinical significance of serum thyroid peroxidase ( TPO ) for differentiated thyroid carcinomas(DTA ) is estimated differently . - pubmed
Therefore , TPO seems to be an indicator for the destruction of normal thyroid cells or thyroid tumor cells . - pubmed
Sera of children with hepatitis C infection and anti - liver - kidney microsome-1 antibodies recognize different CYP2D6 epitopes than adults with LKM+/HCV+ sera . - pubmed
BACKGROUND : Liver - kidney microsome type 1 ( LKM1 ) antibodies are specific markers of autoimmune hepatitis ( AIH ) type 2 . - pubmed
Antibodies to LKM1 have been found in 2 % to 3 % of adults infected with hepatitis C virus ( HCV ) without AIH . - pubmed
LKM1 antibodies in HCV+/LKM1 + sera and in sera of AIH patients do not recognize the same CYP2D6 epitopes . - pubmed
The current study was conducted to determine whether LKM1 antibodies in HCV+/LKM1 + children 's sera are the result of the same immune response as the antibodies described in AIH type 2 and in HCV+/LKM1 + adult patients . - pubmed
Screening of HCV RNA should be performed before starting treatment of presumed autoimmune hepatitis associated with LKM1 . - pubmed
In this report , we investigated methylation status and the expression of the AR gene in normal endometrium and uterine endometrial cancer ( UEC ) tissues using methylation - specific polymerase chain reaction ( MSP ) and immunohistochemical staining . - pubmed
By MSP , 64 of 89 cancer samples showed only methylated AR alleles , although all normal tissues showed both unmethylated and methylated AR alleles . - pubmed
To determine whether similar changes occurred in methylation status in the UEC carcinogenesis , we studied AR methylation using pairs of cancerous and normal samples from 28 patients . - pubmed
Twenty - three of 28 cancer samples showed only methylated AR alleles , although all normal samples showed both unmethylated and methylated alleles . - pubmed
All of the 23 cancer samples that lost unmethylated alleles were negative for AR by immunohistochemical analysis . - pubmed
This study is the first to report that the possible mechanism of AR inactivation in endometrial cancer is through hypermethylation of the AR gene CpG islands . - pubmed
There is compelling evidence that topical corticosteroids down - regulate cytokine expression , and it is likely that a larger , and longer multi - centre trial may prove their efficacy in CRS . - pubmed
Effect of short - term fasting on free and bound leptin concentrations in lean and obese women . - pubmed
The purpose of this study was to evaluate the effect of short - term fasting on bound and free plasma leptin concentrations and leptin binding capacity ( a measure of plasma leptin - binding protein content ) in lean and obese women . - pubmed
Although total plasma leptin concentration was more than 6 - fold greater in obese ( 45.4 + /- 7.6 microg / liter ) compared with lean ( 7.4 + /- 1.0 microg / liter ) women at 14 h of fasting ( P & lt ; 0.05 ) , the percentage of leptin in the bound form was greater in lean than obese subjects ( 29 + /- 2 % vs. 12 + /- 3 % ; P & lt ; 0.05 ) . - pubmed
Arterial total , free , and bound plasma leptin concentrations all declined between 14 h and 22 h of fasting in both lean and obese groups , but the relative decline of these fractions was greater in lean ( 36 + /- 4 % , 60 + /- 9 % , and 51 + /- 13 % , respectively ) than in obese ( 19 + /- 5 % , 21 + /- 8 % , and 12 + /- 7 % , respectively ) subjects ( all P & lt ; 0.05 ) . - pubmed
The percentage of total plasma leptin present in bound form was constant between 14 h and 22 h of fasting in lean subjects and increased slightly but significantly in obese subjects . - pubmed
Cytokine - induced metabolic dysfunction of MIN6 beta cells is nitric oxide independent . - pubmed
BACKGROUND : An important obstacle to islet transplantation is graft injury due to local production of cytokines generated by host nonspecific inflammatory responses . - pubmed
We tested the in vitro effects of interleukin ( IL )- 1 beta , tumor necrosis factor ( TNF ) alpha , and interferon ( IFN ) gamma on glucose - stimulated insulin release in the MIN6 beta - cell line and correlated metabolic dysfunction with NO production and rates of apoptosis . - pubmed
Complete remission in hypoplastic acute myeloid leukemia induced by G - CSF without chemotherapy : report on three cases . - pubmed
Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo . - pubmed
We investigated regulation of vascular endothelial growth factor ( VEGF ) expression by hypoxia in cultured and freshly isolated rat alveolar epithelial cells ( AEC ) . - pubmed
In vitro , hypoxia increased VEGF mRNA and protein levels , with maximal stimulation at 0 % O2 for 18 h. A similar upregulation of VEGF expression was found in alveolar epithelial type II ( ATII ) cells freshly isolated from rats exposed to 8 % O2 for 24 h. In vitro , hypoxia - induced upregulation of VEGF mRNA was due to an increase in transcription , rather than an increase in RNA stability , inasmuch as the half - life of VEGF mRNA was unchanged . - pubmed
Upregulation of VEGF mRNA by hypoxia was mimicked by CoCl2 and desferrioxamine in normoxic AEC and was not prevented by inhibitors of reactive oxygen species , suggesting that hypoxic VEGF regulation involved an O2 - dependent protein that requires ferrous ions but is independent of reactive oxygen species generation . - pubmed
Hypoxia induced a twofold increase in VEGF protein at the apical side of ATII cells in culture and in bronchoalveolar lavage fluid . - pubmed
Improved erectile function after Rho - kinase inhibition in a rat castrate model of erectile dysfunction . - pubmed
Our data support the hypothesis that an active Rho / Rho - kinase pathway contributes to the reduced erectile response after castration due to an upregulation of RhoA / Rho - kinase protein levels and that inhibition of this pathway may serve as an effective treatment for erectile dysfunction . - pubmed
Nitroglycerine administration results in a delayed migraine - like headache in migraine patients but not in control patients , and a nonspecific nitric oxide synthase inhibitor aborted migraine at 2 hours in the majority of tested migraine patients compared to controls . - pubmed
Many patients with familial hemiplegic migraine have a missense mutation in the P / Q calcium channel , so that this form of migraine , at least , is associated with a demonstrable calcium channelopathy . - pubmed
These data show region - specific differences of IL-1beta mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation . - pubmed
Maspin in thyroid cancer : its relationship with p53 and clinical outcome . - pubmed
The serine protease inhibitor maspin has been reported to inhibit invasiveness and motility of tumor cells . - pubmed
Additionally , a p53 - dependent regulatory pathway of maspin in human cancer has been indicated . - pubmed
In a pre - study we were able to detect maspin protein in papillary thyroid carcinomas ( PTC ) , whereas normal ( tumor - free ) thyroid tissue , follicular adenomas , follicular carcinomas , poorly differentiated carcinomas and undifferentiated carcinomas of the thyroid were maspin - negative . - pubmed
The first aim of our study was to determine the prognostic value of maspin protein expression for the recurrence - free and overall survival of PTC patients undergoing radical thyroidectomy and postoperative irradiation . - pubmed
Mutant - type p53 expression was detectable in 17 of 68 PTC ( 25 % ) . - pubmed
This study indicates that maspin protein possibly functions as a clinically relevant inhibitor of tumor progression , preventing local invasiveness and further systemic progression of papillary thyroid carcinomas . - pubmed
Our data hint of a p53 - dependent regulatory pathway of the maspin protein in human cancer . - pubmed
In this study we demonstrate that IL-4Rs are expressed on human hepatocellular carcinoma ( HCC ) cells . - pubmed
Acetylcholine and cholinesterase in the blood of patients suffering with bronchial asthma . - pubmed
High prevalence of type b beta - lactamase - non - producing ampicillin - resistant Haemophilus influenzae in meningitis : the situation in Japan where Hib vaccine has not been introduced . - pubmed
OBJECTIVES : To study yearly changes in resistance and to identify ftsI mutations in beta - lactamase - non - producing ampicillin - resistant ( BLNAR ) and TEM-1 beta - lactamase - producing amoxicillin / clavulanic acid - resistant ( BLPACR ) isolates of Haemophilus influenzae from patients with meningitis . - pubmed
To assess the biotransformation pathways of aplidine and their potential implications for human pharmacology and toxicology , the in vitro metabolism of aplidine was characterized using incubations with human plasma , liver preparations , cytochrome P450 ( CYP ) and uridine diphosphoglucuronosyl transferase ( UGT ) supersomes in combination with HPLC analysis and cytotoxicity assays with cell lines . - pubmed
In accordance with the findings in microsomes and CYP supersomes , a significant effect of specific CYP2A6 , 2E1 , 3A4 and 4A11 inhibitors on the cytotoxicity of aplidine in Hep G2 and IGROV-1 cells could be observed . - pubmed
IGF - I therapy in growth disorders . - pubmed
Patients with GH insensitivity , typically resulting from mutations affecting the GH receptor ( GHR ) , GHR signaling cascade , or the IGF - I gene , are , generally , unresponsive to GH therapy . - pubmed
As interest in the potential efficacy of IGF - I treatment for children currently labeled as idiopathic short stature increases , it will be important to have controlled clinical trials of GH , versus IGF - I versus combination , GH + IGF - I. - pubmed
The protein amount of TGF - beta ( 1 ) and BMP-2 in myocardium of AMI was significantly higher than that in normal myocardium . - pubmed
These in vitro and in vivo results suggest that infarct - related biological and physical factors in AMI induce commitment of MSCs to cardiomyocyte - like cells through TGF - beta / BMP-2 pathways . - pubmed
Identification of downstream targets of estrogen and c - myc in breast cancer cells . - pubmed
These data indicate that a significant component of E - induced mitogenesis is mediated by c - myc and that selected c - myc target genes may be surrogate markers of c - myc expression in BC . - pubmed
FUS is a member of the Ewing ' s sarcoma family of proteins that appears to play a role in regulating genome stability , since mice lacking FUS show chromosomal instability and defects in meiosis . - pubmed
Expression of chemokine receptor CCR7 is associated with cervical lymph node metastasis of oral squamous cell carcinoma . - pubmed
Tumor cell migration and metastasis share many similarities with leukocyte trafficking , which is critically regulated by chemokines and their receptors . - pubmed
The present study was designed to examine the expression of chemokine receptor CCR7 in oral squamous cell carcinoma ( OSCC ) , and to investigate the possible role of CCR7 / CCL21 interaction in neck lymph node metastasis of OSCC . - pubmed
By using immunohistochemistry , RT - PCR and Western Blot , expression of CCR7 was examined in 85 cases of oral squamous cell carcinoma , and Tca8113 and ACC cell lines . - pubmed
In vitro adhesion assay was shown for banding of tumor cell lines to submandibular lymph nodes with or without anti - CCR7 antibody treatment . - pubmed
Immunohistochemical staining showed 65.9 % ( 56/85 ) of positive CCR7 expression in OSCC tissues . - pubmed
CCR7 expression was significantly higher in patients with lymph node metastasis compared with those without lymph node metastasis ( P=0.015 ) and was also associated with tumor size ( P=0.014 ) , and clinical stage ( P=0.009 ) . - pubmed
RT - PCR and Western Blot also confirmed positive CCR7 expression in oral squamous cell carcinoma and Tca8113 cell line , and negative CCR7 expression in normal oral mucosa and ACC cell line . - pubmed
These results indicated that the chemotactic CCR7 / CCL21 interaction may be a possible mechanism for induction of directional lymph node metastasis by oral squamous cell carcinoma . - pubmed
The treatment of pertussis and pneumonia complicating pertussis ; the role of hyperimmune gamma globulin and sulfadiazine . - pubmed
Carbonyl Reductase 3 ( CBR3 ) Mediates 9 - cis - Retinoic Acid - Induced Cytostatis and is a Potential Prognostic Marker for Oral Malignancy . - pubmed
Our results suggest that the cytostatic effects of RA could be mediated by the activation of endogenous CBR3 gene in oral squamous cell carcinomas ( OSCCs ) , and the expression is a potential marker for oral malignancy . - pubmed
In view of the central role of connective tissue growth factor ( CCN2 ) in fibrosis , we investigated the mechanisms by which CCN2 is regulated in PSC following their exposure to ethanol or acetaldehyde . - pubmed
The potential therapeutic effects of inhibitors of ethanol metabolism or anti - oxidants in alcoholic pancreatitis may arise in part through their ability to attenuate CCN2 production by PSC . - pubmed
The incretins and beta - cell health : contrasting glucose - dependent insulinotropic polypeptide and glucagon - like peptide-1 as a path to understand islet function in diabetes . - pubmed
Loss of polycystin-2 ( PC2 ) in mice ( Pkd2(-/- ) ) results in total body edema , focal hemorrhage , structural cardiac defects , abnormal left - right axis , hepatorenal and pancreatic cysts , and embryonic lethality . - pubmed
Global inactivation of Pkd2 produced a phenotype identical to Pkd2(-/- ) mice with undetectable PC2 protein and perinatal lethality . - pubmed
Our results suggest that loss of PC2 disrupts normal behavior of renal epithelial cells through dysregulation of beta - catenin - dependent signaling , revealing a potential role for this signaling pathway in PC2 - associated ADPKD . - pubmed
COX-2 Gene increases tongue cancer cell proliferation and invasion through VEGF - C pathway . - pubmed
COX-2 induces the proliferation and invasion of oral squamous cell carcinoma . - pubmed
A short hairpin RNA ( shRNA)method was used to knock down COX-2 gene expression and investigate the relationship between COX-2 and VEGF - C , and the role of the COX-2 gene for proliferation and invasion was also investigated in the tongue cancer cell Tca8113 . - pubmed
COX-2 gene overexpressed in tongue cancer cell line . - pubmed
Our results suggested that COX-2 played essential roles in the proliferation and metastasis of tongue cancer , and COX-2 could serve as a potential chemotherapy target for tongue cancer . - pubmed
The envelope glycoprotein gp120 of the human immunodeficiency virus ( HIV ) , the causative agent of AIDS , contains approx 24 potential sites for N - glycosylation ( Asn - X - Ser / Thr , X Pro ) ( 1 ) , all of which are utilized and constitute about 50 % of the molecular mass ( 2 ) . - pubmed
TNF alpha antagonist - induced lupus - like syndrome : report and review of the literature with implications for treatment with alternative TNF alpha antagonists . - pubmed
OBJECTIVE : To review clinical characteristics of patients who develop tumor necrosis factor ( TNF ) alpha antagonist - induced lupus - like syndrome ( TAILS ) and review implications for further TNF alpha antagonist therapy . - pubmed
Published reports of individuals who have developed TAILS and those who have continued treatment with alternative TNF alpha antagonists are reviewed . - pubmed
To date , 10 patients with TAILS have continued therapy with an alternative TNF alpha antagonist without recurrence of lupus symptoms . - pubmed
CONCLUSIONS : Development of a DILS after one TNF alpha antagonist does not preclude continued treatment with an alternative TNF alpha antagonist . - pubmed
Multiple endocrine neoplasia type 1 ( MEN1 ) results from mutations in the tumor suppressor gene , MEN1 , which encodes nuclear protein menin . - pubmed
4 ) Menin represses certain pro - proliferative factors involved in endocrine tumors such as IGFBP-2 , IGF2 and PTHrP to repress cell proliferation . - pubmed
In the two diabetic groups , one group ( diabetes mellitus , DM ) was fed a common semi - purified diet while the other group received a diet in which part of the casein was replaced by GLN ( DM - GLN ) . - pubmed
The results showed that blood thioredoxin - interacting protein ( Txnip ) mRNA expression in the diabetic groups was higher than that in the NC group . - pubmed
INTRODUCTION : An international cohort study of 73 anti - Ku - positive patients with different connective tissue diseases was conducted to differentiate the anti - Ku - positive populations of patients based on their autoantibody profile and clinical signs / symptoms and to establish possible correlations between antibodies against Ku p70 and Ku p80 with autoimmune diseases . - pubmed
By using the first and the third components of the principal - component analysis ( PCA ) with 29 parameters evaluated , we observed that the anti - Ku - positive population of UCTD patients had overlapping parameters , especially with SLE , as opposed to SSc , which could be helpful in delineating UCTD patients . - pubmed
A major subgroup of MMPs , the gelatinases ( MMP9 and 2 ) are central to many adult physiological and pathological processes , such as tumor metastasis and angiogenesis , in which cell - cell and cell - matrix contacts are degraded to allow migration . - pubmed
As NCC undergo similar processes during development , we hypothesized that MMP9 may also promote the migration of NCC . - pubmed
Altogether , our study reveals MMP9 as a novel effector which is required for NCC delamination and migration . - pubmed
S100A12 as a marker to predict cardiovascular events in patients with chronic coronary artery disease . - pubmed
BACKGROUND : S100A12 , a calgranulin family protein released from white blood cells , is involved in inflammatory cardiovascular disease . - pubmed
It was hypothesized that the plasma level of S100A12 can be used to predict outcome in patients with chronic coronary artery disease ( CAD ) . - pubmed
The purpose of this study was to clarify the clinical significance of S100A12 in patients with stable CAD . - pubmed
CONCLUSIONS : S100A12 could be a novel biomarker for predicting cardiovascular events for predicting MACE in patients with stable CAD . - pubmed
Influence of the IL6 gene in susceptibility to systemic sclerosis . - pubmed
Interleukin 6 ( IL-6 ) plays a crucial role in immunity and fibrosis , both key aspects of SSc . - pubmed
We investigated the influence of IL6 gene in the susceptibility and phenotype expression of SSc . - pubmed
In the IL6 allelic combination analyses , the GGC allelic combination rs2069827 - rs1800795 - rs2069840 showed an association with overall SSc ( Bonferroni p = 0.016 , OR 1.13 , 95 % CI 1.04 - 1.23 ) . - pubmed
CONCLUSION : Our results suggest that the IL6 gene may influence the development of SSc and its progression . - pubmed
Addiction to cigarette smoking is a prevalent neuropsychiatric disorder that stems from the biophysical and cellular actions of nicotine on nicotinic acetylcholine receptors ( nAChRs ) throughout the central nervous system . - pubmed
Understanding the various nAChR subtypes that exist in brain areas relevant to nicotine addiction is a major priority . - pubmed
Preoperative elevation of carcinoembryonic antigen predicts poor tumor response and frequent distant recurrence for patients with rectal cancer who receive preoperative chemoradiotherapy and total mesorectal excision : a multi - institutional analysis in an Asian population . - pubmed
PURPOSE : This study was conducted to evaluate the significance of carcinoembryonic antigen ( CEA ) level as a predictor for tumor response to chemoradiotherapy ( CRT ) and a prognosticator for survival in Asian patients with advanced rectal cancer . - pubmed
Increased CEA level ( p = 0.025 ) was a significant negative predictor of ypCR after CRT in patients with rectal cancer . - pubmed
CONCLUSIONS : Elevated CEA ( & gt;5 ng / mL ) is a negative predictor of ypCR and has a negative impact on DFS in Asian rectal cancer patients who underwent preoperative CRT and surgery due to an increased chance of distant recurrences . - pubmed
BACKGROUND : Hemorrhagic transformation ( HT ) following acute ischemic stroke is a major problem , especially for the indication of reperfusion therapy including intravenous administration of recombinant tissue plasminogen activator ( IV rt - PA ) . - pubmed
In conclusion , South Indian adult males have Hb values similar to American male adults , but South Indian females have considerably lower Hb levels than American females , raising the questions about appropriateness of WHO or US criteria for detection of anemia in Indian females . - pubmed
Toll - like receptor 4 : innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder . - pubmed
The current review presents evidence that toll - like receptor 4 ( TLR4 ) , via driving both peripheral and central immune responses , can interact with serotonergic neurotransmission and cause neuroendocrine disturbances , thus integrating with widely observed hallmarks of MDD . - pubmed
Additionally , through describing the multi - directional communication between immune , neural and endocrine systems in stress , TLR4 - related mechanisms can mediate stress - induced adaptations , which are necessary for the development of MDD . - pubmed
Therefore , apart from exogenous pathogenic mechanisms , TLR4 is involved in immune changes as a result of endogenous stress signals , playing an integral part in the pathophysiology , and could be a potential target for pharmacological treatments to improve current interventions for MDD . - pubmed
Regarding insulin dynamics , among the NAFLD subjects with both IFG and an HbA1c level of 5.7 - 6.4 % , 25.2 % ( 31/123 ) had elevated IR alone , 25.2 % ( 31/123 ) had insulin secretory deficiency alone and 27.6 % ( 34/123 ) had both elevated insulin resistance and insulin secretory deficiency . - pubmed
CONCLUSION : NAFLD subjects with IFG and an HbA1c level of 5.7 - 6.4 % should undergo OGTT in order to determine whether they have diabetes and/or abnormal insulin dynamics . - pubmed
Novel gain of function mutation in the SLC40A1 gene associated with hereditary haemochromatosis type 4 . - pubmed
Here we report the case of a 69 - year - old Chinese Han woman who presented with liver cirrhosis , diabetes mellitus , skin hyperpigmentation , hyperferritinaemia and high transferrin saturation . - pubmed
BACKGROUND : Monophosphoryl lipid A ( MPLA ) , a nontoxic TLR4 ligand derived from lipopolysaccharide ( LPS ) , is used clinically as an adjuvant in cancer , hepatitis , and malaria vaccines and in allergen - specific immunotherapy . - pubmed
Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression . - pubmed
Aldehyde dehydrogenase 1 ( ALDH1 ) is a recognized cancer stem cell marker but little is known about its role in intratumoral stroma . - pubmed
Therefore , we focused on ALDH1 expression in tumor - associated stroma of breast carcinomas ( BrCa ) . - pubmed
Stromal and tumoral ALDH1 expression was evaluated immunohistochemically in BrCa and their lymph node metastases ( LNMs ) , and related to clinico - pathological characteristics , patients ' outcome , presence of CD68 , HLADR , retinoic acid ( RA ) in stroma , and selected proteins in tumor cells . - pubmed
ALDH1(+ ) stromal cells were detected in 53 % of 374 BrCa and 61 % of 102 LNMs . - pubmed
ALDH1(+ ) stroma in primary tumor correlated to longer disease - free ( p = 0.030 ) , metastasis - free ( p = 0.024 ) , and overall survival ( p = 0.043 ) having an independent prognostic impact on DFS ( multivariate analysis , p = 0.047 ) . - pubmed
It was associated with concomitant presence of HLA - DR(+ ) stromal cells and RA in tumor cells ( both p & lt ; 0.001 ) , and inversely associated with vimentin expression in tumor cells ( p = 0.036 ) . - pubmed
ALDH1(+ ) stroma in LNMs correlated inversely to presence of disseminated tumor cells in patients ' bone marrow ( p = 0.014 ) and was independent prognosticator of shorter DFS and MFS ( multivariate analysis , p = 0.004 and p = 0.002 , respectively ) . - pubmed
In conclusion , ALDH1 expression in tumor - associated stromal cells indicates reduced BrCa progression , possibly via RA secretion . - pubmed
Genetic variants of the POMC and PCSK1 genes cause severe obesity among patients in the early stages of childhood . - pubmed
This family - based study analyzed the links between single nucleotide polymorphisms ( SNPs ) in either the POMC or PCSK1 genes and obesity , as well as obesity - related traits among obese Thai children and their families . - pubmed
The variants rs1042571 and rs6713532 in the POMC gene in a sample of 83 obese children and their family members were investigated using polymerase chain reaction ( PCR)-restriction fragment length polymorphism . - pubmed
However , this analysis did not find any correlation between obesity and SNPs in PCSK1 and POMC . - pubmed
Therefore , these common variants in PCSK1 and POMC were not the major cause of obesity in the Thai subjects sampled . - pubmed
In terms of ZnO - NP - induced cytotoxicity pIL8 - RFP cells were the most affected , whilst the pIL8 - Luc were found the least responsive . - pubmed
Cancer - Specific Synthetic Lethality between ATR and CHK1 Kinase Activities . - pubmed
ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials . - pubmed
Indeed , we observe that replication stress induced by the CHK1 inhibitor AZD7762 results in replication catastrophe and apoptosis , when combined with the ATR inhibitor VE-821 specifically in cancer cells . - pubmed
Combined treatment with ATR and CHK1 inhibitors leads to replication fork arrest , ssDNA accumulation , replication collapse , and synergistic cell death in cancer cells in vitro and in vivo . - pubmed
In conclusion , this study exemplifies cancer - specific synthetic lethality between two proteins in the same pathway and raises the prospect of combining ATR and CHK1 inhibitors as promising cancer therapy . - pubmed
Rapid detection and quantification of tumor marker carbohydrate antigen 72 - 4 ( CA72 - 4 ) using a superparamagnetic immunochromatographic strip . - pubmed
This study highlighted novel roles of EIF2S3Y in the pluripotency maintenance and proliferation control of ES cells , which would provide an efficient model to study germ cell generation as well as cancer development using ES cells , thus providing valuable target for clinical applications of ES cells . - pubmed
Association of Single Nucleotide Polymorphisms in the Apoptosis - Related Genes TP63 and CD40 with Risk for Lung Cancer in a Chinese Han Population . - pubmed
Two single nucleotide polymorphisms ( SNPs ) , rs6790167 ( g243059A>G ) in intron 9 of TP63 and rs1535045 ( g6194C>T ) in intron 1 of CD40 respectively , may affect the susceptibility of lung cancer . - pubmed
Thus , the polymorphisms in the TP63 and CD40 genes are associated with lung cancer in a Chinese Han population . - pubmed
CD133 , Selectively Targeting the Root of Cancer . - pubmed
Tfh-2 cells recently emerged in humans as a strong IL-4 producer Tfh cell subset implicated in both autoimmune and allergic diseases . - pubmed
INTRODUCTION : Ospemifene is a selective estrogen receptor modulator recently approved by the FDA for the treatment postmenopausal women experiencing moderate - to - severe dyspareunia and by the EMA for the treatment of moderate - to - severe symptomatic genitourinary syndrome of menopause ( GSM ) in women who are not suitable candidates for local vaginal estrogen therapy . - pubmed
Arginine deiminase ( ADI ) , an arginine degrading enzyme isolated from Mycoplasma , can inhibit the growth of these tumors . - pubmed
Tumor cells do not express an enzyme called arginosuccinate synthetase ( ASS ) and hence , these cells become auxotrophic for arginine . - pubmed
The PARP inhibitor AZD2461 was developed as a next - generation agent following olaparib , the first PARP inhibitor approved for cancer therapy . - pubmed
Here we demonstrate the efficacy of this compound against olaparib - resistant tumors that overexpress P - glycoprotein . - pubmed
CONCLUSION : The PDE4 inhibitor roflumilast has a favorable side - effect profile at a cognitively effective dose and could be considered as a treatment in disorders affected by disrupted sensory gating . - pubmed
Involvement of mitogen activated kinase kinase 7 intracellular signalling pathway in Sunitinib - induced cardiotoxicity . - pubmed
The tyrosine kinase inhibitor Sunitinib is used to treat cancer and is linked to severe adverse cardiovascular events . - pubmed
Mitogen activated kinase kinase 7 ( MKK7 ) is involved in the development of cardiac injury and is a component of the c - Jun N - terminal kinase ( JNK ) signal transduction pathway . - pubmed
This study investigates the role of ASK1 , MKK7 and JNK during Sunitinib - induced cardiotoxicity . - pubmed
Left ventricular cardiac tissue samples were analysed by qRT - PCR for MKK7 mRNA expression and cardiotoxicity associated microRNAs ( miR-1 , miR-27a , miR-133a and miR-133b ) or Western blot analysis to measure ASK1 / MKK7 / JNK phosphorylation . - pubmed
Co - administration of NQDI-1 ( 2.5 muM ) attenuated the increased Sunitinib - induced infarct size , reversed miR-133a expression and restored phosphorylated levels of ASK1 / MKK7 / JNK . - pubmed
These findings suggest that the ASK1 / MKK7 / JNK intracellular signalling pathway is important in Sunitinib - induced cardiotoxicity . - pubmed
Investigations into the ASK1 / MKK7 / JNK transduction pathway could lead to development of cardioprotective adjunct therapy , which could prevent Sunitinib - induced cardiac injury . - pubmed
Arabidopsis ( Arabidopsis thaliana ) mutants defective in the expression of the OVARIAN TUMOR DOMAIN - CONTAINING DEUBIQUITINATING ENZYME5 ( OTU5 ) exhibited a constitutive Pi deficiency root phenotype , comprising the formation of long and dense root hairs and attenuated primary root growth . - pubmed
[ Expressions of CD96 and CD123 and Their Relationship with Prognosis of Patients with Myelodysplastic Syndrome ] . - pubmed
OBJECTIVE : To explore the relationship between expression of CD96 and CD123 and prognosis of patients with myelodysplastic syndrome(MDS ) . - pubmed
RESULTS : The proportion of CD34 + cells and CD34+CD38- cells in mononuclear cells of patients in MDS group was higher than in control group ( P<0.05 ) . - pubmed
CONCLUSION : The differentiation of CD34 + cells in bone marrow of MDS patients is abnormal , and the high expression of CD123 and CD96 cells existes . - pubmed
The tumor suppressor and cell polarity protein lethal-2 - giant larvae ( Lgl ) promotes Hippo signaling and inhibits Notch signaling to restrict tissue growth in Drosophila melanogaster Notch signaling is greater in lgl mutant tissue than in wild - type tissue because of increased acidification of endosomal vesicles , which promotes the proteolytic processing and activation of Notch by gamma - secretase . - pubmed
Our findings implicate the deregulation of Vap33 and V - ATPase activity in polarity - impaired epithelial cancers . - pubmed
The emergence of cryptic self - antigens such as the LAIR1 ligand ColV during ischemia / reperfusion injury and early acute rejection , as well as the tendency of macrophages / monocytes to accumulate in the allograft during chronic rejection , favors Th17 over Th1 development , posing a risk to long - term graft survival . - pubmed
AAV9 - mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K - Ras - induced lung cancer . - pubmed
This opens the possibility of using telomerase activation as a potential therapeutic strategy to rescue short telomeres both in telomere syndromes and in age - related diseases , in this manner maintaining tissue homeostasis and ameliorating these diseases . - pubmed
In the past , we generated adeno - associated viral vectors carrying the telomerase gene ( AAV9 - Tert ) and shown their therapeutic efficacy in mouse models of cardiac infarct , aplastic anemia , and pulmonary fibrosis . - pubmed
Although we did not observe increased cancer incidence as a consequence of Tert overexpression in any of those models , here we set to test the safety of AAV9 - mediated Tert overexpression in the context of a cancer prone mouse model , owing to expression of oncogenic K - ras . - pubmed
We found that overexpression of Tert does not accelerate the onset or progression of lung carcinomas , even when in the setting of a p53 - null background . - pubmed
These findings indicate that telomerase activation by using AAV9 - mediated Tert gene therapy has no detectable cancer - prone effects in the context of oncogene - induced mouse tumors . - pubmed
High miR-718 Suppresses Phosphatase and Tensin Homolog ( PTEN ) Expression and Correlates to Unfavorable Prognosis in Gastric Cancer . - pubmed
BACKGROUND Phosphatase and tensin homolog ( PTEN ) is a kind of phosphatase which has been demonstrated to suppress progression of gastric cancer . - pubmed
Many micro - RNAs ( miRNAs ) , such as miR-106b , miR-93 , and miR-200c , could inhibit expression of PTEN in cell lines ; and many miRNAs including miR-21 , miR-22 , miR-18a , and miR-222 are related to the progression and prognosis of gastric cancer . - pubmed
MATERIAL AND METHODS The expression of PTEN and miR-718 in 141 gastric cancer tissues were detected by immunohistochemistry and quantitative real - time PCR respectively . - pubmed
RESULTS Low expression of PTEN and high expression of miR-718 were both significantly associated with unfavorable prognosis , and both were identified as biomarkers predicting poorer prognosis of patients with gastric cancer . - pubmed
CONCLUSIONS Low expression of PTEN and increased expression of miR-718 in gastric cancer tissues were both independent unfavorable prognostic factors of gastric cancer . - pubmed
Upregulation of miR-718 could increase PI3K / Akt signaling by directly downregulating PTEN , thus promoting the proliferation and invasion of gastric cancer cells . - pubmed
Elevated Sera sST2 Is Associated With Heart Failure in Men & lt;=50 Years Old With Myocarditis . - pubmed
Elevated sera soluble ( s ) ST2 predicts mortality from acute and chronic heart failure , but has not been studied in myocarditis patients . - pubmed
Sera sST2 levels were higher in healthy men ( P=8x10 - 6 ) and men with myocarditis ( P=0.004 ) compared with women . - pubmed
sST2 levels were elevated in patients with myocarditis and New York Heart Association class III - IV heart failure ( P=0.002 ) , predominantly in men ( P=0.0003 ) . - pubmed
Sera sST2 levels were associated with New York Heart Association class in men with myocarditis who were & lt;=50 years old ( r=0.231 , P=0.0006 ) , but not in women ( r=0.172 , P=0.57 ) . - pubmed
Sera sST2 levels were also significantly higher in male mice with myocarditis ( P=0.005 ) where levels were associated with cardiac inflammation . - pubmed
Gonadectomy with hormone replacement showed that testosterone ( P<0.001 ) , but not estradiol ( P=0.32 ) , increased sera sST2 levels in male mice with myocarditis . - pubmed
Conclusions We show in a well - characterized subset of heart failure patients with clinically suspected and biopsy - confirmed myocarditis that elevated sera sST2 is associated with an increased risk of heart failure based on New York Heart Association class in men & lt;=50 years old . - pubmed
A direct Coombs - negative hemolytic anemia combined with an increased LDH = Lactate dehydrogenase level are signs to test for PNH . - pubmed
Expression , purification , and in vitro mitochondrial interaction analysis of full - length and truncated human tumor suppresser p53 . - pubmed
They were found to have low serum phosphorus , normal calcium , and vitamin D studies , with elevated alkaline phosphatase suggestive of nutritional hypophosphatemia . - pubmed
Histopathologically , the superficially located tumor showed typical features of PXA with melanin - laden astrocytic component and was negative for V600E - mutant BRAF . - pubmed
TTP399 : an investigational liver - selective glucokinase ( GK ) activator as a potential treatment for type 2 diabetes . - pubmed
Introduction : Type 2 diabetes is a complex metabolic disorder defined by hyperglycemia which occurs because of impaired insulin secretion and sensitivity . - pubmed
TTP399 is a hepatoselective , glucokinase activator with potential for treating type 2 diabetes . - pubmed
CONCLUSION : The standard treatment of hormone receptor positive and HER-2 negative metastatic breast cancer is everolimus together with exemestane . - pubmed
Thus , we aimed to elucidate the preventive effect of inosine on locomotor activity , changes in purine levels , and adenosine receptors density in a ketamine - induced model of mania in rats . - pubmed
Inosine pretreatment ( 25 mg / kg , oral route ) prevented the hyperlocomotion induced by ketamine ( 25 mg / kg , intraperitoneal route ) in the open - field test ; however , there was no difference in hippocampal density of A1 and A2A receptors , where ketamine , as well as inosine , were not able to promote changes in immunocontent of the adenosine receptors . - pubmed
In this sense , we suggest further investigation of signaling pathways involving purinergic receptors , using pharmacological strategies to better elucidate the action mechanisms of inosine on bipolar disorder . - pubmed
Direct Determination of Coagulation Factor IIa and Plasmin Activities for Monitoring of Thrombotic State . - pubmed
Factor IIa and plasmin activities could be dynamically monitored in patients with thrombotic disease who were taking oral anticoagulants and used for assessing the hypercoagulable state in pregnant women . - pubmed
CONCLUSIONS : The high specificity , sensitivity , and stability of this novel assay not only makes it useful for determining clinically important protease activities in human blood and diagnosing thrombotic diseases but also provides a new way to monitor the effectiveness and safety of anticoagulant drugs . - pubmed
The paracaspase mucosa - associated lymphoid tissue lymphoma translocation protein-1 ( MALT1 ) regulates nuclear - factor - kappa - B ( NF - kappaB ) activation downstream of surface receptors with immunoreceptor tyrosine - based activation motifs ( ITAMs ) , such as the B - cell or T - cell receptor and has thus emerged as a therapeutic target for autoimmune diseases . - pubmed
However , recent reports demonstrate the development of lethal autoimmune inflammation due to the excessive production of interferon gamma ( IFN - gamma ) and defective differentiation of regulatory T - cells in genetically modified mice deficient in MALT1 paracaspase activity . - pubmed
Treatment with an allosteric MALT1 inhibitor alleviated the cytokine storm , including IFN - gamma , in a mouse model of acute T - cell activation , and long - term treatment did not lead to an increase in IFN - gamma producing CD4 cells or tissue inflammation . - pubmed
Together , our data demonstrate that the effects of allosteric inhibition of MALT1 differ from those seen in mice with proteolytically inactive MALT1 , and thus we believe that MALT1 is a viable target for B and T - cell driven autoimmune diseases . - pubmed
CONCLUSION : It can be concluded that resveratrol modulated alveolar bone loss during experimental periodontitis progression in estrogen - deficient rats by downregulating NADPH oxidase levels . - pubmed
Such 3D constructs generally have a naturally occurring hypoxic center , which allows for the stabilization of HIF-1alpha in the interior tissue . - pubmed
High mobility group box 1 induces bone pain associated with bone invasion in a mouse model of advanced head and neck cancer . - pubmed
Recurrent SPECC1L - NTRK fusions in paediatric sarcoma and brain tumours . - pubmed
The identification of rearrangements driving expression of Neurotrophic Receptor Tyrosine Kinase ( NTRK ) family kinases in tumours has become critically important due to the availability of effective , specific inhibitor drugs . - pubmed
Here we describe three SPECC1L - NTRK fusions identified in two paediatric central nervous system cancers and an extracranial solid tumour using WGS and RNAseq . - pubmed
We report here that SPECC1L - NTRK fusions can arise in a range of paediatric cancers . - pubmed
Galeterone sensitizes breast cancer to chemotherapy via targeting MNK / eIF4E and beta - catenin . - pubmed
Aberrant activation of eIF4E signalling pathway is common in breast cancer and holds potential therapeutic options . - pubmed
In our work , galeterone as a chemical compound under clinical trials for the treatment of prostate cancer , was identified to be effective in targeting breast cancer cells via suppressing MNK - eIF4E and beta - catenin . - pubmed
Rescue studies demonstrated that both MNK / eIF4E and beta - catenin were responsible for anti - breast cancer activity of galeterone . - pubmed
LncRNA PDCD4 - AS1 alleviates triple negative breast cancer by increasing expression of IQGAP2 via miR-10b-5p . - pubmed
This study was designed to detect the influences and regulatory mechanism of lncRNA PDCD4 - AS1 in triple - negative breast cancer ( TNBC ) . - pubmed
METHODS : qRT - PCR and Western blot were utilized to investigate the expression levels of PDCD4 - AS1 , miR-10b-5p and IQGAP2 in TNBC tissues and cells . - pubmed
RESULTS : In this work , PDCD4 - AS1 and IQGAP2 were lowly expressed while miR-10b-5p was strongly expressed in TNBC tissues and cells . - pubmed
PDCD4 - AS1 or IQGAP2 overexpression effectively attenuated TNBC cell proliferation , migration and invasion , and increased the apoptosis rate , while this effect was abandoned in response to miR-10b-5p mimics transfection . - pubmed
CONCLUSION : Our findings identified lncRNA PDCD4 - AS1 as a tumor suppressor in TNBC by regulating IQGAP2 expression via miR-10b-5p , giving a novel insight into the regulatory mechanism of PDCD4 - AS1 in the pathogenesis of TNBC . - pubmed
The findings suggest that alteration of the cell surface membrane and microfilaments prevents damage by interfering with cell - target interactions , that energy derived from glycolysis is required for cytotoxicity , that cell - associated esterases are probably involved , and that cytotoxicity may be modulated by cyclic nucleotides . - pubmed
Favism in a Portuguese family due to a deficient glucose - phosphate dehydrogenase variant ( Canton ) or ( cpanton - like ) type . - pubmed
CA 125 levels in monitoring therapy for endometriosis and in prediction of recurrence . - pubmed
CA 125 levels were measured in the serum of 18 patients with laparoscopically diagnosed stage 2 to stage 4 endometriosis ( American Fertility Society classification ) and in eight normally cycling control women . - pubmed
The mean CA 125 level in women with endometriosis was significantly higher than that observed in normal women ( 28.6 + /- 5.1 ( + /- SE ) units / mL vs. 11.1 + /- 1.1 units / mL ) . - pubmed
Four of the patients who had recurrence of symptoms approximately 1 year after treatment had CA 125 levels close to pretreatment levels , and recurrence of endometriosis was confirmed by laparoscopy . - pubmed
These results indicate that ( 1 ) CA 125 level can predict active endometriosis lesions in patients with stage 3 and stage 4 endometriosis , but is of no value for predicting adhesions ; ( 2 ) CA 125 levels are useful in monitoring therapy during treatment ; ( 3 ) during the follow - up period , elevations in CA 125 might predict recurrence of disease in women with stage 3 and stage 4 endometriosis.(ABSTRACT TRUNCATED AT 250 WORDS ) - pubmed
As more has become known about the mechanisms by which abnormal levels of circulating lipoproteins promote atherosclerosis , certain risk factors have emerged as concerns for women , including : ( 1 ) diabetes mellitus as a risk factor , perhaps through its more profound effects on circulating lipoproteins ; ( 2 ) serum triglyceride levels , and ( 3 ) changes in high - density lipoprotein cholesterol . - pubmed
Although human T cell surface glycoprotein CD4 is the cellular receptor for human immunodeficiency virus 1 ( HIV-1 ) , the introduction of the human CD4 gene into murine cells does not render them susceptible to HIV-1 infection . - pubmed
HPRT gene mutations in a female Lesch - Nyhan patient . - pubmed
The value of penicillinase sensitive penicillins in treating superficial wound infections is questioned . - pubmed
[ Study of growth hormone gene in non - familial complete somatotropin deficiency ] . - pubmed
On the basis of the results the neuroendocrine nature of this uncommon neoplasm of the skin is confirmed and it is suggested that chromogranin A could represent an additional marker for Merkel cells tumors . - pubmed
Administrations ( injections and in feed ) of bromocriptine , a dopamine agonist that inhibits prolactin secretion , reduced body fat stores and plasma total cholesterol and triglyceride concentrations in several rodent species ( Syrian hamsters , Djungarian hamsters , Swiss Webster mice and obese Zucker rats ) . - pubmed
These findings offer further evidence for a primary role of prolactin in lipid metabolism and indicate that bromocriptine may be useful for treating obesity and lipid - based cardiovascular disorders . - pubmed
The available data from experimental and clinical studies suggest that in the development of hypertension following correction of renal anemia under rhEPO three mechanisms are operative : ( 1 ) an increase in whole blood viscosity ; ( 2 ) possible also a reduction of hypoxic vasodilatation , and ( 3 ) at least in some patients an inadequate reduction of cardiac output . - pubmed
To avoid cardiovascular complications under rhEPO therapy , the following should be considered : Patients that were hypertensive before the start of renal replacement therapy , even if they were normotensive in the anemic state - because of morphological alterations of their peripheral vascular bed - may run a higher risk for developing hypertension under rhEPO . - pubmed
Patients who are hypertensive under rhEPO therapy should be treated by antihypertensive drugs as appropriate . - pubmed
Two calcium - binding proteins in infiltrate macrophages of rheumatoid arthritis . - pubmed
In acutely inflamed tissues , macrophages can express MRP-14 but not MRP-8 , and in chronic inflammations , such as primary chronic polyarthritis , infiltrate macrophages express both MRP-8 and MRP-14 . - pubmed
Characterization of MRP-8 and MRP-14 could therefore be useful to the understanding of cellular processes induced in chronic inflammation . - pubmed
The role of fibronectin in the process of wound healing . - pubmed
Thus , hyperglycemia may exert an inhibitory effect on the plasma GH response to hGHRH-44 . - pubmed
The mechanisms by which elevated levels of vasopressin ( ADH ) in man and animals cause serious myocardial dysfunction , evidenced by arrhythmias , reduction in cardiac output and coronary blood flow , are not settled . - pubmed
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16 ) in malignant liposarcoma . - pubmed
We show that the translocation t(12;16)(q13 : p11 ) in malignant myxoid liposarcoma can be a fusion of the CHOP dominant negative transcription factor gene with a novel gene , FUS , which can result in fusion of the FUS glycine - rich protein with the whole CHOP coding region . - pubmed
Correlation of magnetic resonance imaging features with cytokine production by tumor cells . - pubmed
Immunohistochemistry was performed for immunophenotyping and for cytokine expression by tumor cells . - pubmed
Immunohistochemical stains showed a B - cell phenotype for each tumor and positive immunoreactivity in tumor cells for cytokine mediators that stimulate osteoclastic activation . - pubmed
CONCLUSIONS : These findings indicate that the tumor cells in these cases produce soluble cytokine mediators that may regulate extensive osteoclastic activity . - pubmed
To clarify the role of serotonin , the in vivo and in vitro effects of the selective 5 - HT2 receptor antagonist , DV-7028 , on MCT - induced pulmonary hypertension were studied . - pubmed
Regional adoptive immunotherapy with interleukin-2 and lymphokine - activated killer ( LAK ) cells for liver metastases . - pubmed
Patients with liver metastases received continuous high - dose infusion of interleukin-2 ( IL-2 ) into the splenic artery or intravenous infusion with subsequent transfer of lymphokine - activated killer ( LAK ) cells into the portal vein or the hepatic artery . - pubmed
The usual side - effects of IL-2 and LAK cells occurred without limiting liver toxicity . - pubmed
Galaptin and galaptin - binding glycoconjugates in serum and effusions of carcinoma patients . - pubmed
The objectives of this study were ( 1 ) to quantify galaptin , an endogenous lectin , and galaptin - binding glycoconjugates present in normal serum , ( 2 ) to determine if these components were altered in the serum and effusions of carcinoma patients with advanced disease , and ( 3 ) to determine if ovarian carcinoma cells synthesize and release soluble galaptin inhibitors . - pubmed
Galaptin levels in carcinoma patient serum ( n = 29 ) were depressed ( mean 21 + /- 23 ng / ml ; p & lt ; 0.0001 ) . - pubmed
Galaptin was not detected in 6 of 8 ovarian carcinoma patient sera . - pubmed
The data presented show that the levels of soluble galaptin and galaptin - binding glycoconjugates in the serum of advanced cancer patients are perturbed relative to normal female serum . - pubmed
The unexpected observation that the increased T cells were mainly CD4 may be related to the mild GVHR and the clinical improvement . - pubmed
Prognostic significance of 67 - kDa laminin receptor expression in advanced gastric cancer . - pubmed
The ability of cancer cells to attach to laminin has been correlated with their metastatic potential and highly metastatic cancer cells seem to express on their surface significantly more laminin receptors than do their much less metastatic or benign counterparts . - pubmed
The expression of 67 - kDa laminin receptors ( LR ) was investigated in a group of 75 patients who underwent gastrectomy for advanced gastric cancer , with special reference to the possible role in the tumor progression and in the overall survival . - pubmed
The tumor LR expression was immunohistochemically determined in paraffin - embedded sections using the MLuC5 monoclonal antibody which recognizes the 67 - kDa LR and the avidin - biotin immunoperoxidase method . - pubmed
A significant association between LR expression and depth of tumor invasion ( 0.022 ) was found . - pubmed
By univariate analysis the presence of laminin receptors seemed to be associated with a higher risk of death [ RR 1.72 ( 95 % CI 0.71 - 4.20 ] , but this effect disappeared after controlling for depth of tumor invasion . - pubmed
In conclusion , these results suggest that tumor expression of laminin receptors could be correlated with tumor aggressiveness . - pubmed
However , the prognostic significance of laminin receptor expression is already provided by the depth of tumor invasion . - pubmed
Structural analysis of the C - CAM1 molecule for its tumor suppression function in human prostate cancer . - pubmed
BACKGROUND : Recently , we demonstrated that expression of C - CAM1 , an immunoglobulin ( Ig )- like cell adhesion molecule ( CAM ) , was diminished in both prostate intraepithelial neoplasia and cancer lesions , indicating that loss of C - CAM1 expression may be involved in the early events of prostate carcinogenesis . - pubmed
Also , increased C - CAM1 expression can effectively inhibit the growth of prostate cancer . - pubmed
In this study , we further analyzed the functional domain of C - CAM1 for controlling its tumor suppression function . - pubmed
RESULTS : In vivo tumorigenic assay indicated that AdCAMDeltaD1 without cell adhesion function still retained its tumor suppression activity . - pubmed
CONCLUSIONS : Our data indicate that the intracellular domain of the C - CAM1 molecule is critical for inhibiting the growth of prostate cancer , suggesting that C - CAM1 interactive protein(s ) may dictate prostate carcinogenesis . - pubmed
Granulocyte colony - stimulating factor -- primed allogeneic bone marrow transplants : capturing the advantages of blood stem cell transplants without increased risk of chronic graft - versus - host disease . - pubmed
MyoD1 and myogenin expression in human neoplasia : a review and update . - pubmed
Terguride treatment attenuated prolactin release and enhanced insulin receptor affinity and GLUT 4 content in obese spontaneously hypertensive female , but not male rats . - pubmed
Glucose tolerance , serum insulin , insulin receptors in epididymal fat tissue , and GLUT 4 content in muscle , as well as serum prolactin , were studied in obese and lean spontaneously hypertensive rats ( SHRs ) of both sexes . - pubmed
Obese animals displayed insulin resistance and decreased capacity of high - affinity binding sites of insulin receptors in fat tissue plasma membranes . - pubmed
GLUT 4 content in musculus quadriceps was diminished only in obese females . - pubmed
Terguride treatment lowered prolactin serum levels , which was concomitant with ameliorated insulin sensitivity in obese animals of both sexes . - pubmed
Similarly , only in obese females , terguride significantly increased the affinity of high - affinity insulin - binding sites and normalized GLUT 4 content . - pubmed
Our results document downregulation of insulin receptors and GLUT 4 in obesity and suggest a role for prolactin in obesity - induced insulin resistance , particularly in female rats . - pubmed
Treatment of cutaneous T cell lymphoma with extracorporeal photopheresis induces Fas - ligand expression on treated T cells , but does not suppress the expression of co - stimulatory molecules on monocytes . - pubmed
Exposure to high concentrations of glucose and insulin results in insulin resistance of metabolic target tissues , a characteristic feature of type 2 diabetes . - pubmed
In contrast to findings after long - term hyperglycemia , there was no membrane translocation of novel isoforms of protein kinase C in skeletal muscle after 6 h. These data support the concept that oxidative stress contributes to the pathogenesis of hyperglycemia - induced insulin resistance . - pubmed
Current treatments of human immunodeficiency virus type 1 ( HIV-1 ) infection consist in the combination of drugs targeting reverse transcriptase ( RT ) and protease ( PR ) . - pubmed
Silibinin down - regulates prostate epithelium - derived Ets transcription factor in LNCaP prostate cancer cells . - pubmed
The androgen - sensitive human prostate cancer cell line LNCaP expresses the estrogen receptor beta and androgen receptor and can be stimulated by androgens to secrete prostate - specific antigen ( PSA ) . - pubmed
In this study we demonstrate the cancer protective potential of silibinin , a flavolignan derived from the fruits of Silybum marianum , which down - regulates the co - activator of the androgen receptor , the prostate epithelium - derived Ets transcription factor ( PDEF ) and consequently the secretion of PSA . - pubmed
Our results indicate that , in contrast to ATM , Chk2 activity is triggered by a greater number of DSBs , implying that , below a certain threshold level of lesions ( & lt;19 DSBs ) , DNA repair can occur through ATM , without enforcing Chk2 - dependent checkpoints . - pubmed
He was given the gonadotropin - releasing hormone agonist leuprolide acetate and the androgen receptor antagonist flutamide for the treatment of prostate cancer . - pubmed
After improvement of hyperglycemia by insulin treatment , their glycemic control remained good after treatment with pioglitazone without use of insulin . - pubmed
Exposure of tissue factor ( TF)-bearing cells to blood is the initial event in coagulation and intravascular thrombus formation . - pubmed
OBJECTIVES : The primary objective of the study was to evaluate the immunogenicity of a combined hepatitis A and hepatitis B vaccine compared to the effect of the administration of two monovalent hepatitis A and B vaccines by quantitative measurements of the anti - HBs antibody levels at month 2 of the vaccination course . - pubmed
Seroprotection against hepatitis B was defined as anti - HBs antibody concentration & gt ; or = 10 IU / l , and longterm seroprotection as & gt ; or = 100 IU / l. RESULTS : In all , 288 subjects completed the study . - pubmed
Erlotinib ( Tarceva , OSI-774 ; Pfizer , Inc. ) is an orally - active , targeted inhibitor of the epidermal growth factor receptor ( EGFR / HER1 ) , which is part of a key regulatory pathway in cancer . - pubmed
Negative impact of human leukocyte antigen matching in the outcome of polyomavirus nephropathy . - pubmed
We correlated the number of matched HLA - A , HLA - B , and HLA - DR antigens with graft outcome in 90 patients with PVAN . - pubmed
Indeed , when transduced in human colon carcinoma LoVo cells , a mutant proPC1 incapable of cleaving off its prodomain was shown to accumulate in the nucleus . - pubmed
Molecular aspects of gefitinib antiproliferative and pro - apoptotic effects in PTEN - positive and PTEN - negative prostate cancer cell lines . - pubmed
One of the major targets for the therapy in PCa can be epidermal growth factor receptor ( EGFR ) , which signals via the phosphoinositide 3 '- kinase ( PI3K)/Akt and mitogen - activated protein kinase ( MAPK ) pathways , among others . - pubmed
Despite multiple reports of overexpression in PCa , the reliance on activated EGFR and its downstream signalling to the PI3 K and/or MAPK / extracellular signal - regulated kinase ( ERK ) pathways has not been fully elucidated . - pubmed
We reported that the EGFR - selective tyrosine kinase inhibitor gefitinib ( ZD1839 ; Iressa ) is able to induce growth inhibition , G(1 ) arrest and apoptosis in PCa cells and that its effectiveness is associated primarily with phosphatase and tensin homologue deleted from chromosome 10 ( PTEN ) expression ( and thus Akt activity ) . - pubmed
In fact PTEN - negative PCa cells are slowly sensitive to gefitinib treatment , because this molecule is unable to downregulate PI3K / Akt activity . - pubmed
The MAPK pathway seems to be involved primarily on cell - growth modulation because dual blockade of EGFR and ERK1 / 2 phosphorylation potentiates growth inhibition ( both not cell apoptosis ) in PTEN - positive PCa cells and reduced EGF - mediated growth in PTEN - negative cells . - pubmed
Therefore , our data suggest that the inhibition of EGFR signalling can result in a significant growth reduction and in increased apoptosis in EGFR - overexpressing PCa cells with different modalities , which are regulated by PTEN status , and this may have relevance in the clinical setting of PCa . - pubmed
Out of diabetic mothers , only 19 ( 47.5 % ) were taking insulin albeit irregularly . - pubmed
Cathepsin K in adipocyte differentiation and its potential role in the pathogenesis of obesity . - pubmed
CTSK was up - regulated in the WAT of overweight / obese subjects , and it had a significant positive correlation with body mass index . - pubmed
CTSK may be involved in the pathogenesis of obesity by promoting adipocyte differentiation . - pubmed
This article describes the regulation of human CD4 + T cell responses to glutamic acid decarboxylase 65 ( GAD65 ) , an autoantigen implicated in type-1 diabetes , by autologous CD8 + suppressor T cells . - pubmed
In this study , we performed two - dimensional differentiation in - gel electrophoresis of tumors treated with anti - mir-21 and identified the tumor suppressor tropomyosin 1 ( TPM1 ) as a potential mir-21 target . - pubmed
Finally , overexpression of TPM1 in breast cancer MCF-7 cells suppressed anchorage - independent growth . - pubmed
Thus , down - regulation of TPM1 by mir-21 may explain , at least in part , why suppression of mir-21 can inhibit tumor growth , further supporting the notion that mir-21 functions as an oncogene . - pubmed
Angiotensin - converting enzyme gene polymorphism and stroke in type 2 diabetic patients in Taiwan . - pubmed
BACKGROUND : The effect of traditional risk factors on the association between angiotensin - converting enzyme ( ACE ) gene insertion / deletion ( I / D ) polymorphism and stroke was rarely studied previously . - pubmed
CONCLUSION : Traditional risk factors play an important role in the association between the ACE genotypes and stroke . - pubmed
Tumor immune escape mediated by indoleamine 2,3 - dioxygenase . - pubmed
Amongst the numerous mediators contributing towards the escape of tumors from the host 's immune response against them , the enzyme indoleamine 2,3 - dioxygenase ( IDO ) has recently attracted special attention . - pubmed
The recent identification of IDO - expressing tumor cells has implicated this molecule as a key mediator of the tumor immune escape . - pubmed
Mounting evidence indicates that , within the tumor microenvironment , not only tumor cells but also other infiltrating cells such as dendritic cells , monocytes and others can be sources of IDO . - pubmed
IDO - induced tryptophan depletion from the tumor microenvironment could be the result of either elevated levels of the enzyme or augmented tryptophan consumption by both tumor cells and antigen presenting cells of the host . - pubmed
Finally , evidence emerges indicating that IDO possibly promotes tumor immune escape by inducing an immunoregulatory or an anergic T cell phenotype at a systemic level . - pubmed
BACKGROUND : Little research has explored the association of macronutrient intake and glycated hemoglobin ( HbA ( 1c ) ) in adults with diabetes . - pubmed
BACKGROUND : Initiation of an atherosclerotic lesion requires endothelial expression of adhesion molecules . - pubmed
This is at least partially caused by hyperglycemia and hyperinsulinemia increasing adhesion molecule expression . - pubmed
The endothelin - converting enzyme-1 / endothelin-1 pathway plays a critical role in inflammation - associated premature delivery in a mouse model . - pubmed
Furthermore , we have previously shown that both the endothelin - converting enzyme-1 ( ECE-1 ) inhibitor , phosphoramidon , as well as a novel ET-1 receptor A antagonist synthesized by our group , control premature delivery in a mouse model of inflammation - associated preterm delivery . - pubmed
Taken together , these data support a critical role for the ECE-1 / ET-1 system in inflammation - associated premature delivery . - pubmed
We used the combined dexamethasone suppression / CRH stimulation ( Dex - CRH ) test to evaluate the degree of HPA - axis dysregulation in 194 in - patients with unipolar depression from the Munich Antidepressant Response Signature ( MARS ) study at both admission and discharge . - pubmed
Vascular endothelial growth factor and its receptor may be one molecular mechanism for androgenetic alopecia . - pubmed
Braf(V600E ) cooperates with Pten loss to induce metastatic melanoma . - pubmed
Mutational activation of BRAF is the earliest and most common genetic alteration in human melanoma . - pubmed
To build a model of human melanoma , we generated mice with conditional melanocyte - specific expression of BRaf(V600E ) . - pubmed
Upon induction of BRaf(V600E ) expression , mice developed benign melanocytic hyperplasias that failed to progress to melanoma over 15 - 20 months . - pubmed
By contrast , expression of BRaf(V600E ) combined with Pten tumor suppressor gene silencing elicited development of melanoma with 100 % penetrance , short latency and with metastases observed in lymph nodes and lungs . - pubmed
Melanoma was prevented by inhibitors of mTorc1 ( rapamycin ) or MEK1 / 2 ( PD325901 ) but , upon cessation of drug administration , mice developed melanoma , indicating the presence of long - lived melanoma - initiating cells in this system . - pubmed
The present study therefore aimed to detect main effects as well as interactions of serotonergic candidate genes ( coding for the serotonin transporter , 5 - HTT ; the serotonin autoreceptor , HTR1A ; and the enzyme which synthesizes serotonin in the brain , TPH2 ) with the burden of life events ( # LE ) in two independent samples consisting of 183 patients suffering from personality disorders and 123 patients suffering from adult attention deficit / hyperactivity disorder ( aADHD ) . - pubmed
Only the G allele of HTR1A rs6295 seemed to increase the risk of emotional - dramatic cluster B personality disorders ( p = 0.019 , in the personality disorder sample ) and to decrease the risk of anxious - fearful cluster C personality disorders ( p = 0.016 , in the aADHD sample ) . - pubmed
By doing so , we observed nominal evidence for G x E effects as well as main effects of 5 - HTT - LPR and the TPH2 SNP rs4570625 on the occurrence of personality disorders . - pubmed
Osteopontin is a secreted , integrin - binding and phosphorylated acidic glycoprotein , which has an important role in tumour progression . - pubmed
We have shown that Wnt , Ets , AP-1 , c - jun and beta - catenin / Lef-1 / Tcf-1 stimulates OPN transcription in rat mammary carcinoma cells by binding to a specific promoter sequence . - pubmed
RESULT : MTS assay results showed the enhanced cytotoxicity of anticancer drugs ( Oxaliplatin , Doxorubicin and Etopside ) to the H460 cell line with keap1 overexpression compared to the control cell line . - pubmed
Down - regulation of Nrf2 enhanced the cytotoxicity of Oxaliplatin , Doxorubicin and Etopside . - pubmed
Down - regulation of Nrf2 enhanced the cytotoxicity of Oxaliplatin , Doxorubicin and Etopside . - pubmed
Identification and analysis of a Sciaenops ocellatus ISG15 homologue that is involved in host immune defense against bacterial infection . - pubmed
ISG15 homologues have been identified in a number of fish species , some of which are known to be regulated at expression level by virus infection and lipopolysaccharide ( LPS ) treatment . - pubmed
However , the relationship between ISG15 and live bacterial infection has not been investigated in piscine models . - pubmed
Taken together , the results of this study indicated that SoISG15 possesses apparent immunological property and is likely to be involved in host immune defense against bacterial infection . - pubmed
Platelet - derived growth factor ( PDGF ) functions as a chemotactic factor for dermal fibroblasts and plays an important role in the progression of melanoma . - pubmed
American Society of Clinical Oncology / College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer . - pubmed
PURPOSE : To develop a guideline to improve the accuracy of immunohistochemical ( IHC ) estrogen receptor ( ER ) and progesterone receptor ( PgR ) testing in breast cancer and the utility of these receptors as predictive markers . - pubmed
RECOMMENDATIONS : The Panel recommends that ER and PgR status be determined on all invasive breast cancers and breast cancer recurrences . - pubmed
It is recommended that ER and PgR assays be considered positive if there are at least 1 % positive tumor nuclei in the sample on testing in the presence of expected reactivity of internal ( normal epithelial elements ) and external controls . - pubmed
Exercise training reduces insulin resistance and upregulates the mTOR / p70S6k pathway in cardiac muscle of diet - induced obesity rats . - pubmed
Acting through the Akt / mTOR pathway , insulin has numerous and important physiological functions , such as the induction of growth and survival of many cell types and cardiac hypertrophy . - pubmed
However , obesity and insulin resistance can alter mTOR / p70S6k . - pubmed
To evaluate the effect of exercise training on mTOR / p70S6k in the heart of obese Wistar rats , we analyzed the effects of 12 weeks of swimming on obese rats , induced by a high - fat diet . - pubmed
Toll - like receptor 2 and poly ( ADP - ribose ) polymerase 1 promote central nervous system neuroinflammation in progressive EAE . - pubmed
The algorithm proposed here could result in a suitable approach for faster and more effective identification of hit and/or lead compounds with tyrosinase inhibitory activity , helping to shorten the long pipeline in the research of novel depigmenting agents to treat skin disorders . - pubmed
In vitro and in vivo evaluation of 64Cu - radiolabeled KCCYSL peptides for targeting epidermal growth factor receptor-2 in breast carcinomas . - pubmed
Epidermal growth factor receptor-2 ( EGFR-2 ) has been implicated in the pathogenesis of breast and other carcinomas . - pubmed
In this report , we tested the ability of a bacteriophage selected peptide KCCYSL , radiolabeled with 64Cu , to image EGFR-2 expressing breast tumors in vivo by positron emission tomography ( PET ) . - pubmed
The optimization of bifunctional chelators improves the pharmacokinetic properties of the 64Cu - labeled GSG - KCCYSL peptide , which enables the selection of a suitable peptide homolog as a PET imaging agent for EGFR-2 expressing breast carcinomas . - pubmed
The NICE guidelines state that general practitioners should measure serum CA125 in women presenting with persistent and continuous symptoms suggestive of ovarian cancer ( e.g. - pubmed
Sensitization of tumor cells by targeting histone deacetylases . - pubmed
On the basis of their pro - apoptotic activity , HDAC inhibitors have been combined with conventional antitumor agents or novel target - specific agents to increase susceptibility to apoptosis and drug sensitivity of cancer cells . - pubmed
Overexpression of matrix metalloproteinases ( MMPs ) and other proteases by tumor cells allows intravasation of tumor cells into the circulatory system after degrading the basement membrane and ECM ( 9 ) . - pubmed
Elevated levels of MMPs have been found in tumors associated with a poor prognosis for cancer patients ( 13 ) . - pubmed
MMP2 is one of the major enzymes involved in the remodeling of the left ventricle after ischemia and reperfusion ( I / R ) in the heart ( 14 ) . - pubmed
A connexin40 mutation associated with a malignant variant of progressive familial heart block type I. - pubmed
This is the first demonstration of a germ line mutation in a connexin gene that associates with inherited ventricular arrhythmias and emphasizes the importance of Cx40 in normal propagation in the specialized conduction system . - pubmed
Frequent activating GNAS mutations in villous adenoma of the colorectum . - pubmed
To elucidate the role of GNAS mutations in colorectal tumourigenesis , we performed a mutation analysis in a total of 234 colorectal tumours , including adenomas , serrated lesions and adenocarcinomas . - pubmed
Activating GNAS mutations were found in 20 of the 24 villous adenomas ( 83 % ) but were absent in all the other tumours , except for one tubulovillous adenoma ( 3 % ) and two adenocarcinomas ( 3 % ) . - pubmed
KRAS mutations were frequent in villous ( 67 % ) and tubulovillous ( 60 % ) adenomas but were rare or absent in tubular adenomas ( 6 % ) and serrated lesions , including hyperplastic polyps , sessile serrated polyps / sessile serrated lesions and traditional serrated adenomas ( 0 - 9 % ) . - pubmed
BRAF mutations were found in four villous adenomas ( 17 % ) and in the large majority of serrated lesions ( 81 - 92 % ) , but were absent in tubular and tubulovillous adenomas . - pubmed
Seventeen villous adenomas ( 71 % ) harboured GNAS mutations concomitantly with KRAS or BRAF mutations . - pubmed
Immunohistochemically , all the villous adenomas retained mismatch repair protein expression , suggesting that they are microsatellite - stable . - pubmed
The current study showed that the presence of activating GNAS mutations , in association with KRAS or BRAF mutations , is a characteristic genetic feature of colorectal villous adenoma . - pubmed
In the present study we attempted to elucidate the mechanisms of glomerular injury induced by FK506 and the renoprotective effects of the angiotensin II receptor blocker telmisartan . - pubmed
CONCLUSION : These findings suggest that glomerular injury resulting from FK506 is caused by oxidative stress mediated by activation of NAD ( P ) H oxidase and that telmisartan exerts a renoprotective effect via antioxidative activity . - pubmed
The 42 - mer amyloid beta - protein ( Abeta42 ) aggregates to form soluble oligomers that cause memory loss and synaptotoxicity in Alzheimer ' s disease ( AD ) . - pubmed
We previously identified the toxic conformer of Abeta42 with a turn at positions 22 and 23 ( " toxic turn " ) by solid - state NMR and demonstrated that a monoclonal antibody ( 11A1 ) against the toxic turn in Abeta42 mainly detected the oligomer in the brains of AD patients . - pubmed
Our recent study suggested that oxidative stress is a key factor of the oligomerization and cognitive impairment induced by Abeta overproduction in vivo . - pubmed
E22P - Abeta42 , but not E22V - Abeta42 , induced greater ROS production than Wt - Abeta42 in addition to potent neurotoxicity . - pubmed
Interestingly , the formation of the toxic conformer in both E22P - Abeta42 and Wt - Abeta42 probed by the 11A1 antibody preceded Abeta42 - induced neurotoxicity . - pubmed
A peripheral blood cytogenetic analysis is performed due to a high suspicion of leukemia , and the results show BCR / ABL fusion gene with a cut point in the M - BCR region , which confirms the diagnosis of chronic myeloid leukemia . - pubmed
Neu2000 ( NEU ; 2 - hydroxy-5 -( 2,3,5,6 - tetrafluoro-4 - trifluoromethyl - benzylamino )- benzoic acid ) , a recently developed derivative of acetylsalicylic acid and sulfasalazine , potently protects against neuronal cell death following ischemic brain injury by antagonizing NMDA receptor - mediated neuronal toxicity and oxidative stress . - pubmed
These results suggest that NEU attenuates hypoxia - induced impairment of neuronal activity more potently than the antioxidant , trolox , and the NMDA receptor antagonists , ifenprodil and APV . - pubmed
Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter - induced gastric malignancy . - pubmed
The role of MyD88 in Helicobacter - induced gastric malignancy is unknown . - pubmed
Using a mouse model of Helicobacter - induced gastric cancer , we assessed the role of MyD88 in cancer development by evaluating gastric histopathology , apoptosis , proliferation , and cytokine expression . - pubmed
The progression of Helicobacter - induced disease to precancerous and cancerous lesions in the absence of MyD88 signaling was accompanied by increased gastric epithelial apoptosis and proliferation . - pubmed
In addition , inflammatory cytokines , including tumor necrosis factor alpha ( TNF - alpha ) , gamma interferon ( IFN - gamma ) , IL-6 , and IL-1beta were highly expressed in association with the development of gastric dysplasia . - pubmed
These data suggest that MyD88 signaling retards development and progression to cancer during Helicobacter infection . - pubmed
This is the first study to show evidence of MyD88 protection in an infection - driven inflammation - associated cancer model . - pubmed
A key feature of Parkinson disease is the aggregation of alpha - synuclein and its intracellular deposition in fibrillar form . - pubmed
COX-2 gene expression is correlated with cognitive function in recurrent depressive disorder . - pubmed
Cyclooxygenase-2(COX-2 ) may be a key inflammatory enzyme involved in recurrent depressive disorder(rDD ) . - pubmed
In rDD group , COX-2 expression were higher and significant correlations occurred between COX-2 expression and cognitive functions . - pubmed
Thus , the COX-2 enzyme may be important for cognitive functioning in rDD . - pubmed
These clinical implications entail that CgA and its derived peptides are now used as diagnostic and prognostic markers or to monitor the response to pharmacological intervention not only in endocrine tumors , but also in cardiovascular , inflammatory , and neuropsychiatric diseases . - pubmed
PELP1 - depleted p53 ( wild - type ) breast cancer cells were less sensitive to various genotoxic agents including etoposide , camptothecin or gamma - radiation . - pubmed
Overall , these studies established a new role of PELP1 in DDRs and these findings will have future implications in our understanding of PELP1 's role in cancer progression . - pubmed
Finally , intravenous injection of the probe after cerebral ischemia revealed activation of caspase-3 in the infarcted hemisphere . - pubmed
METHODS : Tumor free ( n = 37 ) and metastatic ( n = 17 ) lymph nodes of T1 and T2 oscc patients were processed for immunohistochemistry to detect CD68 , CD11c , CD163 and MRC1 positive cells . - pubmed
In platelet - rich plasma ( PRP ) therapy , various growth factors and cytokines released the alpha - granules contained in platelets after activation can potentially enhance wound healing by delivering . - pubmed
In the longitudinal follow - up , each additional year of vegan diet lowered the risk of obesity by 7 % ( 95 % CI 0 88 , 0 99 ) , whereas each additional year of lacto - vegetarian diet lowered the risk of elevated SBP by 8 % ( 95 % CI 0 85 , 0 99 ) and elevated glucose by 7 % ( 95 % CI 0 87 , 0 99 ) , and each additional year of ovo - lacto - vegetarian diet increased abnormal HDL by 7 % ( 95 % CI 1 03 , 1 12 ) , compared with non - vegetarians . - pubmed
MATERIAL AND METHODS : 181 people were examined for the presence of anti - A. phagocytophilum IgG antibodies ; 113 were patients with suspected TBE ( 65 males , 48 females ) , and 68 from the control group ( 18 males , 50 females ) . - pubmed
OBJECTIVE : To characterize the clinical features and MRI abnormalities of leucine - rich glioma - inactivated 1 ( LGI1)-autoantibody ( Ab ) faciobrachial dystonic seizures ( FBDS ) . - pubmed
METHODS : Forty - eight patients with LGI1 - Ab encephalopathy were retrospectively identified by searching our clinical and serologic database from January 1 , 2002 , to June 1 , 2015 . - pubmed
Of these , 26 met inclusion criteria for this case series : LGI1 - Ab seropositivity and FBDS . - pubmed
A separate analysis of all 48 patients initially identified with LGI1 - Ab encephalopathy showed that basal ganglia MRI abnormalities were present in 11 of 26 with FBDS but not present in those without FBDS ( 0/22 ) ( p & lt ; 0.001 ) . - pubmed
CONCLUSIONS : Basal ganglia T1 hyperintensity is a clinically useful MRI biomarker of LGI1 - Ab FBDS and suggests a basal ganglia localization . - pubmed
Evaluation of the gingival inflammation in pregnancy and postpartum via 25 - hydroxy - vitamin D3 , prostaglandin E2 and TNF - alpha levels in saliva . - pubmed
In the pregnant healthy , gingivitis and periodontitis groups saliva TNF - alpha levels were significantly lower than postpartum and control counterparts ( p<0.0001 , p=0.032 , p=0.003 and p=0.013 ; p=0.027 ; p=0.007 , respectively ) . - pubmed
The unexpected positive staining for PAX-2 , PAX-8 and CD10 in renal hemangioblastoma needs to be aware . - pubmed
Stem cells enhance neurogenesis and Abeta clearing as well as improved cognitive impairment . - pubmed
We investigated whether RA patients in long - term remission are characterized by normalized inflammatory activity of the arterial wall and if this is dependent on type of medication used ( TNF - inhibitor versus nonbiological disease - modifying antirheumatic drugs ( DMARDs ) ) . - pubmed
However , RA subjects using current anti - TNF therapy ( n = 13 , disease activity score 1.98[1.8 - 2.2 ] ) have an almost 1.2 - fold higher ( 18 ) F - FDG uptake in the arterial wall compared to those using DMARDs ( but with previous anti - TNF therapy ) ( n = 10 , disease activity score 2.24[1.3 - 2.5 ] ) , which seemed to be predominantly explained by longer duration of their rheumatic disease in a multivariate linear regression analysis . - pubmed
Finally , we found increased activity in bone marrow and spleen in RA patients using anti - TNF therapy compared to those with DMARDs and controls . - pubmed
CONCLUSIONS : A subset of patients with RA in clinical remission have activated monocytes and increased inflammation in the arterial wall , despite the use of potent TNF blocking therapies . - pubmed
Comprehensive Profiling of the Androgen Receptor in Liquid Biopsies from Castration - resistant Prostate Cancer Reveals Novel Intra - AR Structural Variation and Splice Variant Expression Patterns . - pubmed
BACKGROUND : Expression of the androgen receptor splice variant 7 ( AR - V7 ) is associated with poor response to second - line endocrine therapy in castration - resistant prostate cancer ( CRPC ) . - pubmed
We performed profiling of circulating tumour DNA via low - pass whole - genome sequencing and targeted sequencing of the entire AR gene , including introns . - pubmed
Targeted RNA sequencing was performed on enriched circulating tumour cell fractions to assess the expression levels of seven AR splice variants ( ARVs ) . - pubmed
Six out of 17 poor responders were AR - V7 - negative , but four carried other AR perturbations . - pubmed
CONCLUSION : CEA can be performed safely in patients receiving dialysis , but further operative procedures and careful postoperative management are likely to be needed for patients with CEA who are receiving dialysis . - pubmed
The dose - dependent negative effect of transfusions was also found in favorable subgroups ( pT1 tumor , hemoglobin & gt;=13 mg / dl , p = .004 ) and in a high - volume surgeon subgroup ( n = 244 , p & lt ; .001 ) . - pubmed
Study outcomes included the incidence of bladder perforation and obturator jerk , decrease in hemoglobin and sodium levels , rates of re - coagulation and blood transfusion , TUR syndrome , and operation time . - pubmed
Mucin 5B in saliva and serum of patients with oral lichen planus . - pubmed
This study aimed to assess the level of Mucin 5B in OLP patients with xerostomia . - pubmed
Level of Mucin 5B in unstimulated saliva was significantly lower in OLP group ( P = 0.0001 ) while it was not significantly different in stimulated saliva of the two groups ( P & gt ; 0.05 ) . - pubmed
Level of Mucin 5B was significantly higher in serum of OLP patients ( P = 0.016 ) . - pubmed
Both saliva flow and level of Mucin 5B decrease in OLP patients . - pubmed
Since Mucin 5B is effective for wetting and lubrication of the oral cavity , this result can suggest a possible reason for mouth dryness in OLP patients . - pubmed
It is not known exactly where amyloid - beta ( Abeta ) fibrils begin to accumulate in individuals with Alzheimer ' s disease ( AD ) . - pubmed
Recently , we showed that abnormal levels of Abeta42 in cerebrospinal fluid ( CSF ) can be detected before abnormal amyloid can be detected using PET in individuals with preclinical AD . - pubmed
The earliest Abeta accumulation is further associated with hypoconnectivity within the DMN and between the DMN and the frontoparietal network , but not with brain atrophy or glucose hypometabolism . - pubmed
Our results suggest that Abeta fibrils start to accumulate predominantly within certain parts of the DMN in preclinical AD and already then affect brain connectivity . - pubmed
CONCLUSION : According to the present findings , it can be concluded that the intraurethral administration of LPS promotes tissue remodeling , as well as stimulating the pattern of pro - inflammatory cytokines , and therefore , constitutes an effective experimental model of BPH / inflammation . - pubmed
CONCLUSIONS : Modest weight loss in postmenopausal women has a lowering effect on leptin concentrations over 24 months which may improve inflammatory status whilst modest weight gain increases ICAM-1 , leptin and TNF - alpha , markers which are associated with a pro - inflammatory state and vascular complications . - pubmed
Substitutions of PrP N - terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice . - pubmed
Novel transgenic mice expressing PrP(TetraH > G ) at levels comparable to wild - type ( wt ) controls were susceptible to mouse - adapted scrapie strain RML but showed significantly prolonged incubation times . - pubmed
High BCAR1 expression is associated with early PSA recurrence in ERG negative prostate cancer . - pubmed
BACKGROUND : Breast cancer anti - estrogen resistance 1 ( BCAR1 / p130cas ) is a hub for diverse oncogenic signaling cascades and promotes tumor development and progression . - pubmed
METHODS : To understand the effect of BCAR1 in prostate cancer , we analyzed its expression on more than 11,000 prostate cancer samples . - pubmed
RESULTS : BCAR1 staining was barely detectable in normal prostate glands but seen in 77.6 % of 9472 interpretable cancers , including strong expression in 38.5 % , moderate in 23.2 % and weak in 15.9 % of cases . - pubmed
BCAR1 up regulation was associated with positive ERG status ( p & lt ; 0.0001 ) , high Gleason score ( p & lt ; 0.0001 ) , advanced pathological tumor stage ( p = 0.0082 ) , lower preoperative PSA level ( p & lt ; 0.0001 ) , increased cell proliferation ( p & lt ; 0.0001 ) , early PSA recurrence ( p = 0.0008 ) , and predicted prognosis independently from clinico - pathological parameters available at the time of the initial biopsy . - pubmed
However , subset analyses revealed that the prognostic impact of BCAR1 expression was limited to ERG - negative cancer . - pubmed
CONCLUSION : The results of our study identify BCAR1 as a prognostic biomarker with potential clinical value for risk stratification of ERG - negative prostate cancer . - pubmed
2 - aminopurine suppresses the TGF - beta1 - induced epithelial - mesenchymal transition and attenuates bleomycin - induced pulmonary fibrosis . - pubmed
Idiopathic pulmonary fibrosis ( IPF ) is a progressive and fatal disease characterized by fibroblast accumulation and collagen deposition in the lungs . - pubmed
Collectively , we determined that 2 - AP could inhibit metastasis in vitro by suppressing the TGF - beta1 - induced EMT and could attenuate BLM - induced pulmonary fibrosis in vivo . - pubmed
However , it has been reported that many cellular activators , including vascular endothelial growth factor ( VEGF ) , are produced by tumor cells after PDT . - pubmed
We evaluated the efficacy of bevacizumab - based anti - angiogenesis in combination with PDT as well as the resulting VEGF levels and microvessel density ( MVD ) in a mouse model of human colon cancer . - pubmed
Enzyme - linked immunosorbent assay ( ELISA ) and immunohistochemistry ( IHC ) were performed to assess VEGF concentrations and microvessel density in the various treatment groups , and confocal imaging and high performance liquid chromatography ( HPLC ) analyses were used to measure the distribution and concentration of mTHPC in tumors . - pubmed
Immunostaining and ELISA analyses revealed a lower expression of VEGF in tumors treated with combination therapy of PDT followed by bevacizumab . - pubmed
In the case of Ebola virus , for example , the discovery of the lysosomal protein NPC1 as an intracellular receptor sparked the development of tailored strategies to interfere with viral infection . - pubmed
HIF-1alpha drives cyst growth in advanced stages of autosomal dominant polycystic kidney disease . - pubmed
However , the functional impact of HIF-1alpha in cystic kidney disease was unknown . - pubmed
A new study has shown that HIF-1alpha promotes cyst progression in a mouse model of autosomal - dominant polycystic kidney disease . - pubmed
CD44 splice isoform switching determines breast cancer stem cell state . - pubmed
Here we report that splice isoforms of the cancer stem cell ( CSC ) marker CD44 exhibit strikingly opposite functions in breast cancer . - pubmed
Bioinformatic annotation in patient breast cancer in The Cancer Genome Atlas ( TCGA ) database reveals that the CD44 standard splice isoform ( CD44s ) positively associates with the CSC gene signatures , whereas the CD44 variant splice isoforms ( CD44v ) exhibit an inverse association . - pubmed
These results reveal CD44 isoform specificity in CSC and non - CSC states and suggest that alternative splicing provides functional gene versatility that is essential for distinct cancer cell states and thus cancer phenotypes . - pubmed
We evaluated the histamine 's role in regulating the iris vasomotricity in rats , using as a research tool topical olopatadine , a selective H1 blocker , which is indicated for the treatment of allergic conjunctivitis and ranitidine , a selective H2 blocker mainly used for the treatment of peptic ulcer disease . - pubmed
Olopatadine , a topical H1 antagonist used in the treatment of ocular allergies , may interfere with the humoral regulation of the iris arteriolar tone . - pubmed
Contribution of Matrix Metalloproteinase-2 Promoter Genotypes to Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan . - pubmed
BACKGROUND / AIM : Matrix metalloproteinase 2 ( MMP2 ) is up - regulated in many cancers . - pubmed
However , the association of MMP2 genotype to nasopharyngeal cancer ( NPC ) susceptibility in Taiwan remains elusive . - pubmed
MATERIALS AND METHODS : In this study , the role of MMP2 promoter C-1306 T ( rs243865 ) and C-735 T ( rs2285053 ) genotypes were investigated among 208 NPC patients and 416 healthy controls , and their role in NPC staging and TNM classifications were examined . - pubmed
CONCLUSION : CT and TT genotypes at MMP2 C-1306 T were associated with a significantly decreased risk of NPC metastasis . - pubmed
In the patient group , correlation and adjustment analyses showed associations of OST with various disease activity markers [ DAS28 ( rho=0.313 ) , swollen joint counts ( rho=0.361 ) , CRP ( rho=0.389 ) ; all , padj=0.001 ) ] , age ( rho=0.276 , p<0.001 ) and osteoarthritis ( p=0.022 ) . - pubmed
Finally , we showed that ZIKV - infected mouse models displayed similar CAM upregulation and that soluble CAMs were increased in plasma samples from ZIKV - infected patients . - pubmed
The Rho guanine nucleotide exchange factor ( RGNEF ) protein encoded by the ARHGEF28 gene has been implicated in the neurodegenerative disease amyotrophic lateral sclerosis ( ALS ) . - pubmed
Biochemical and pathological studies have shown that RGNEF is a component of the hallmark neuronal cytoplasmic inclusions in ALS - affected neurons . - pubmed
Additionally , a heterozygous mutation in ARHGEF28 has been identified in a number of familial ALS ( fALS ) cases that may give rise to one of two truncated variants of the protein . - pubmed
Little is known about the normal biological function of RGNEF or how it contributes to ALS pathogenesis . - pubmed
Additionally , through unbiased screening using the split - ubiquitin system , we have identified RGNEF - interacting proteins , including two ALS - associated proteins . - pubmed
Our findings indicate that RGNEF misfolding and toxicity may cause impairment of the microtubule network and contribute to ALS pathogenesis . - pubmed
Protective effect of proton pump inhibitors and potassium competitive acid blockers against post - gastric endoscopic submucosal dissection bleeding : a single - center , propensity score - matched analysis . - pubmed
We examined the cross - sectional relationship between serum levels of 8 pro - inflammatory markers ( IL-1beta , IL-6 , TNF - alpha , IL-8 , MCP-1 , CXCL10 , IL-12p70 , CRP ) and performance on a detailed neuropsychological assessment battery in middle - aged adults with uncomplicated T2DM ( N = 89 ; 52 + - 8.1 years , 47 % female ) and matched healthy controls ( N = 50 ; 52 + - 8.3 years , 59 % female ) . - pubmed
We observed a significant T2DM - specific association between serum TNF - alpha levels and scores on the Paired Associates Learning ( PAL ) task ( beta : -3.16 , SE : 1.32 , p = 0.01 , Std . - pubmed
We provide exploratory evidence for a significant T2DM - specific relationship between serum TNF - alpha and memory performance . - pubmed
Role of mixed - function oxidase in 3 - methylindole - induced acute pulmonary edema in goats . - pubmed
The relationship between the pulmonary toxicity of 3 - methylindole ( 3MI , skatole ) and the mixed - function oxidase ( MFO ) system was investigated . - pubmed
Results indicate that the MFO system is one of the pathways involved in the metabolism of 3MI and that pulmonary toxicosis results from metabolism of 3MI by this enzyme system . - pubmed
The anti - melanoma monoclonal antibody HMB45 is widely used in diagnostic pathology owing to its great specificity and sensitivity in identifying pigmented tumors such as malignant melanoma . - pubmed
Thus , HMB45 may identify an oncofetal antigen present in cutaneous melanocytes , RPE , and melanoma cells , and changes in immunoreactivity with maturation or malignant transformation may be a function of post - translational modification . - pubmed
An evaluation of ovarian carcinoma - associated antigen defined by murine monoclonal antibody CF511 in sera from patients with ovarian carcinoma . - pubmed
Murine monoclonal antibody CF511 , raised against human ovarian clear cell carcinoma , detects a glycoprotein ( Mr 600 kDa ) called CF511 antigen which is elevated in the serum of many patients with ovarian carcinoma . - pubmed
A competitive enzyme - linked immunosorbent assay was developed to detect CF511 antigen in human serum and used to detected CF511 antigen in subjects with ovarian carcinoma and other diseases . - pubmed
Raised serum levels of CF511 antigen were found in 6/46 patients ( 13.0 % ) with benign gynaecological tumours ( including endometriosis or ovarian cyst ) , in 5/7 patients ( 71.4 % ) with breast carcinoma and 16/21 ( 76.2 % ) lung carcinoma patients . - pubmed
Determination of CF511 antigen levels may be useful for detection of ovarian carcinoma as well as lung and breast carcinomas and for monitoring progress of disease and response to therapy . - pubmed
[ HLA antigens in diffuse toxic goiter ] . - pubmed
The paper is concerned with some data of investigation of the association of the HLA - system with the development of diffuse toxic goiter ( DTG ) . - pubmed
Comparative analysis of the distribution of HLA - antigens was performed in 50 patients with various degrees of DTG severity , different therapeutic methods ( operative and conservative ) and outcomes of disease ( postoperative hypothyrosis , DTG recurrence and euthyroid condition ) . - pubmed
Basic fibroblast growth factor in human pituitary tumours . - pubmed
Immunoreactive ( ir ) basic fibroblast growth factor ( FGF ) has been measured in normal human pituitary glands and in 41 pituitary tumours of various types using a radioimmunoassay . - pubmed
Normal pituitary glands contained ir basic FGF ranging from 29.4 to 355 fmol / mg wet weight whereas 87.5 % of pituitary tumours contained amounts of the growth factor which were less than normal . - pubmed
There was no relationship between the type of tumour and the FGF content . - pubmed
Because of our previous observation that basic FGF inhibits the growth of human pituitary tumour cells , it is suggested that the reduction in basic FGF of many pituitary tumours may favour the stimulation of pituitary growth . - pubmed
Reciprocal interference between milk - transmitted mammary tumor virus and Friend leukemia viruses in mice : possible role of the interferon system . - pubmed
These data suggest that physical exercise may play an important role in the maintenance of HDL mass and in the reduction of CHD risk factors in women of postmenopausal years with NIDDM . - pubmed
Presence of beta - hexosaminidase A alpha - chain mRNA in two different variants of GM2 - gangliosidosis . - pubmed
On the molecular level it has been shown , that poly ( A)+ RNA preparations from fibroblasts of patients with classical Tay - Sachs disease lack detectable alpha - chain message when analyzed by Northern blotting with complementary DNA encoding the alpha - chain of human beta - hexosaminidase A. - pubmed
In this report the p beta H alpha-5 clone was used to investigate whether patients with two different variants of Tay - Sachs disease also lack the alpha - chain message . - pubmed
The changes in serum triglycerides , cholesterol and high density lipoprotein ( HDL ) cholesterol were followed in patients with pneumonia caused by different bacteria or viruses as well as in those with no defined aetiology . - pubmed
2 ) a reduction in cholesterol in all aetiological groups ( p less than 0.001 ) except for those with viral pneumonias , where only 4 patients were studied , and 3 ) a fall in HDL cholesterol in all the groups ( at least at p less than 0.05 ) except in those with virus infection . - pubmed
In the present study a monoclonal antibody against estrogen receptor ( H222 Sp gamma ) was used on cryostat sections of freshly frozen breast tumors with a peroxidase - antiperoxidase immunoperoxidase technique . - pubmed
Hypopituitarism : a study of growth hormone and other endocrine functions . - pubmed
C - reactive protein in malaria . - pubmed
C - Reactive protein has not been studied in malaria so far but with the reappearance of malaria in the southern part of Iran there is now an opportunity to study the behaviour of C - reactive protein in malaria . - pubmed
It may be concluded that malaria is one of the outstanding diseases in which the C - reactive protein test is positive . - pubmed
Short asthmatic children and human growth hormone . - pubmed
Albuminuria is below 25 mg / d/1.73 m2 and excretion of beta 2 - microglobulin below 0.4 mg / d/1.73 m2 . - pubmed
Dose - response studies were also performed in both salivary glands with different pharmacological agonists known to cause salivation in the rat ( methacholine , noradrenaline , isoproterenol , methoxamine and substance P ) in the absence and in the presence of ANF . - pubmed
Synthetic inhibitors of tissue kallikrein : effects in vivo in a model of allergic inflammation . - pubmed
Several of these were evaluated in vivo in the ovalbumin - sensitised guinea pig for their ability to prevent the bronchoconstriction elicited by antigen challenge . - pubmed
Inhibitors of tissue kallikrein may prove effective in the treatment of allergic inflammation in man . - pubmed
Sequential study of an experimental model of graft vs. host disease ( GvHD ) in non - immunosuppressed F1 ( CBA / J x C57BL/6 ) mice . - pubmed
Long - term management of adenomyosis with a gonadotropin - releasing hormone agonist : a case report . - pubmed
No evidence for association of dopamine D2 receptor variant ( Ser311 / Cys311 ) with major psychosis . - pubmed
We investigated a variant of the dopamine D2 receptor gene ( Ser311 / Cys311 substitution ) in Caucasian patients with schizophrenia ( n = 273 ) , delusional disorder ( n = 62 ) , bipolar I affective disorder ( n = 63 ) , and controls ( n = 255 ) . - pubmed
Thus , our results do not provide evidence for an association between this D2 receptor variant and schizophrenia , or delusional disorder , or bipolar affective disorder . - pubmed
Study of autoantibodies against the adenine nucleotide translocator in idiopathic dilated cardiomyopathy . - pubmed
The frequency , dynamical change and effects of autoantibodies against the adenine nucleotide translocator ( ANT ) in idiopathic dilated cardiomyopathy ( IDC ) were studied . - pubmed
Sera of 16 patients with IDC showed significant binding capacity to the ANT protein ( 33.3 % ) . - pubmed
Therefore , a short - term immunosuppressive treatment should be given to those IDC patients whose anti - ANT antibody is positive . - pubmed
Studies of total proteins , lysozyme and glucose in 25 patients ( 50 eyes ) with Sjogren ' s disease and 26 patients ( 52 eyes ) with Sjogren ' s syndrome have revealed a statistically significant reduction of tear production in patients vs. the normal subjects . - pubmed
The Langerhans and lymphoid cells were counted using immunolabelling with antibodies against CD1a , S100 , CD3 , CD20 , and CD68 on paraffin - embedded sections of 24 archival laryngeal vocal cord mucosa biopsy specimens , 6 classified as simple , 7 as abnormal , and 11 as atypical epithelial hyperplasia . - pubmed
Association between MICA gene A4 allele and acute anterior uveitis in white patients with and without HLA - B27 . - pubmed
PURPOSE : Acute anterior uveitis is strongly associated with the HLA - B27 antigen and triggered by the involvement of some external factors . - pubmed
However , it is uncertain whether HLA - B27 itself or other gene(s ) near the HLA - B region in a linkage disequilibrium with HLA - B27 predispose to this uveitis . - pubmed
METHODS : We examined the following patients for MICA gene polymorphism by means of polymerase chain reaction and subsequent automated fragment detection by fluorescent - based technology : 64 ( 37 HLA - B27 - positive and 27 HLA - B27 - negative ) whites with acute anterior uveitis , 74 ( 67 HLA - B27 - negative and 7 HLA - B27 - positive ) ethnically matched random controls , and 36 HLA - B27 - positive healthy controls . - pubmed
CONCLUSIONS : These results suggest that the MICA gene itself or other nearby gene(s ) linked to the MICA A4 allele may be involved in the development of acute anterior uveitis in a white population . - pubmed
NSAIDs cause gastrointestinal damage by 2 independent mechanisms : a topical effect , which is pH and pKa related , and a systemic effect mediated by cyclooxygenase ( COX ) inhibition with a reduction in prostaglandin synthesis . - pubmed
Among the strategies used to decrease the risk of ulcer development are : ( i ) the use of analgesics other than NSAIDs ; ( ii ) use of the lowest possible dosage of NSAID ; ( iii ) the use of a COX-2 selective NSAID ; ( iv ) the use of low doses of corticosteroids instead of NSAIDs ; ( v ) avoidance of concomitant use of NSAIDs and corticosteroids ; and ( vi ) use of preventive therapy . - pubmed
In an attempt to reduce the incidence of NSAID - induced gastrointestinal lesions , the following approaches have been proposed : ( i ) use of the prostaglandin analogue misoprostol , which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID - induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications ; ( ii ) histamine H2 receptor antagonists ( H2 antagonists ) , e.g. - pubmed
If NSAID treatment can not be withdrawn , a proton pump inhibitor appears to be the most effective treatment in healing ulcers , accelerating the slow healing observed with H2 antagonists . - pubmed
Recent reports have demonstrated beneficial effects of proinsulin C - peptide in the diabetic state , including improvements of kidney and nerve function . - pubmed
Standardization of cellular immunoenzyme assay for anti - HLA class I antibodies evaluation : comparison with complement - dependent cytotoxicity methods . - pubmed
Zanamivir , an inhibitor of neuraminidase , delivered via inhalation , shows promise in the treatment of uncomplicated influenza infection , but more data are needed on its effectiveness and safety in patients with preexisting respiratory disease . - pubmed
Surface expression of the lysosomal membrane protein GP53 was significantly higher in the hypertriglyceridemic patients at baseline as compared to the group of age- and sex - matched controls ( 16.3+/-4.8 % vs. 8.9+/-3.4 % , respectively , P<0.001 ) . - pubmed
The deletion allele frequency of ACE gene was slightly higher in ischaemic stroke group , but with no statistic significance . - pubmed
CONCLUSION : The results suggested that possible association existed between the use of COC and the onset of hemorrhagic stroke , however the mutations of G1691 - ->A in factor V gene , G20210 - ->A in prothrombin gene and I / D polymorphism of ACE gene did not seem to contribute to this association . - pubmed
In multivariate analyses , human leucocyte antigen ( HLA ) disparity between donor and recipient and chronic graft - versus - host disease were the leading causes affecting immune reconstitution . - pubmed
Interestingly , cytomegalovirus ( CMV ) infections were strongly associated with normal CD8 + T - cell counts . - pubmed
Studying the impact of impaired immune reconstitution on the rate of infections occurring in the 6 years following screening , we identified three parameters ( low B - cell count , inverted CD4 / CD8 ratio , and negative response to tetanus toxin ) as significant risk factors for developing such late infections . - pubmed
BACKGROUND : The aim of this study was to identify the factors determining the circulating soluble transferrin receptor ( sTfR ) concentrations in haemodialysis ( HD ) patients on maintenance recombinant human erythropoietin ( rHuEpo ) treatment . - pubmed
HD patients received constant rHuEpo doses and basal sEpo was measured & gt ; or = 86 h after the last injection . - pubmed
RESULTS : HD patients were similar to controls regarding haematocrit , serum ferritin , TS , and % HRC , but had significantly lower sTfR , sEpo , and reticulocyte index . - pubmed
Univariate analyses showed that the sTfR level strongly correlated with sEpo ( r=0.60 , P<0.001 ) and % HRC ( r=0.60 , P<0.001 ) , and significantly with serum ferritin ( r=-0.29 , P<0.01 ) , TS ( r=-0.27 , P<0.05 ) , and dose of rHuEpo administered ( r=0.27 , P<0.05 ) in HD patients . - pubmed
CONCLUSIONS : Circulating sTfR is a good index of marrow erythropoietic activity in HD patients during rHuEpo treatment . - pubmed
Serum carcinoembryonic antigen level in surgically resected clinical stage I patients with non - small cell lung cancer . - pubmed
BACKGROUND : There is little general agreement concerning the effectiveness of serum carcinoembryonic antigen ( CEA ) as a prognostic indicator for non - small cell lung cancer ( NSCLC ) in clinical stage I patients . - pubmed
Serum CEA levels were measured with an enzyme - linked immunosorbent assay kit with the upper limit of normal defined as 7.0 ng / mL based on the 95 % specificity level for benign lung disease , in our hospital . - pubmed
The high CEA group had a median survival time of 50 months and a 5 - year survival rate of 49 % compared with a 5 - year survival rate of 72 % ( p & lt ; 0.0001 ) for the normal CEA group ( n = 241 ) . - pubmed
CONCLUSIONS : Serum CEA level is a useful predictor of survival for patients with clinical stage I NSCLC , and a persistently high CEA level after surgery is an especially strong indicator of a very poor prognosis . - pubmed
The " protein only " hypothesis holds that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP , a host protein predominantly expressed in brain and is strongly supported by many lines of evidence . - pubmed
Coagulation Factor V Leiden has not been detected in Japanese patients suffering from thromboses . - pubmed
Correlations of hemoglobin index ( IHb ) of gastric mucosa with Helicobacter pylori ( H. pylori ) infection and inflammation of gastric mucosa . - pubmed
The haemoglobin index ( IHb ) of the fundic mucosa is an objective parameter of the extent of mucosal redness , but it is unclear whether or not IHb can be used as a diagnostic marker for H. - pubmed
pylori infection , inflammatory cell infiltration , and IL-8 / iNOS mRNA expression , suggesting that IHb is a reliable marker of H. - pubmed
None of the gonadoblastomas showed immunoreactivity with antibodies against steroid hormone receptors and against testosterone and estradiol , respectively . - pubmed
Although multiple studies suggest a potential role for angiotensin II in inflammation , most were performed either in vitro or in animals with non - immune - complex - mediated diseases . - pubmed
In autoimmune - prone MRL / lpr mice , angiotensin - converting - enzyme ( ACE ) inhibition improved survival although to a lesser degree than cyclophosphamide and diminished the glomerular histopathologic damage , proteinuria , lymphoid hyperplasia , dermatitis , and hypergammaglobulinemia , with a reduction in TGF - beta1 and beta 2 expression in the kidneys and renal chemokine mRNA expression . - pubmed
Uncontrolled studies in patients with treatment - refractory lupus nephritis showed a significant reduction in proteinuria with ACE - inhibitors and Angiotensin receptor blockers treatment . - pubmed
No single ACE genotype was consistently associated with subsets of SLE patients . - pubmed
The use of hepatotoxic signals to predict the safety of peroxisome proliferator - activated receptor agonists . - pubmed
Non - invasive imaging of firefly luciferase reporter gene expression using bioluminescence imaging in human prostate cancer models . - pubmed
In the present study , we employed a CCD ( charge - coupled - device ) imaging system to monitor how a prostate - specific adenovirus vector ( AdPSA - Luc ) mediated the long - term , sustained expression of firefly luciferase ( Luc ) in living human prostate cancer mouse models . - pubmed
Systemic tail vein injection of AdPSA - Luc revealed significant luciferase expression in lungs of both human prostate cancer mouse models and naive mice , but significantly higher in the former , while the control virus , AdCMV - Luc , containing CMV ( cytomegalovirus ) promoter and luciferase gene , just restricted expression in the livers . - pubmed
Acceleration of wound healing in aged rats by topical application of transforming growth factor - beta ( 1 ) . - pubmed
The impaired wound healing associated with aging may reflect inadequate secretion or delivery of cytokines . - pubmed
Transforming growth factor - beta ( 1 ) is a mitogenic polypeptide with beneficial effects on wound healing . - pubmed
In the present study we questioned whether topical administration of transforming growth factor - beta ( 1 ) could improve the wound healing process in aged rats in vivo . - pubmed
In addition , the number of capillaries per unit area of the wound as determined by a stain for Griffonin ( Bandeiraea ) simplicifolia lectin , and the number of inflammatory cells as identified by an antibody specific for macrophages , were also reduced in the wound area in old rats . - pubmed
Treatment with transforming growth factor - beta ( 1 ) resulted in marked enhancement of the following parameters : cell proliferation , inflammatory cell and fibroblast influx , wound closure , and angiogenesis . - pubmed
Treatment with transforming growth factor - beta ( 1 ) subsequently resulted in an increase in the expression of both type I procollagen and Secreted Protein , Acidic and Rich in Cysteine mRNA in the wound tissue from aged rats . - pubmed
In summary , a single topical application of transforming growth factor - beta ( 1 ) to the wounds of aged rats at the time of wounding was associated with a healing response that , in all the parameters of wound repair examined , was similar to that of young rats . - pubmed
Topical transforming growth factor - beta ( 1 ) might therefore be beneficial in the treatment of dermal wounds in the aged . - pubmed
Recently , association of an interleukin-1A promoter polymorphism ( -889 , thymine / thymine ( T / T ) ) with Alzheimer ' s disease was reported , suggesting that this cytokine may play an important role in disease development . - pubmed
To understand the mechanism underlying the interleukin-1A promoter 's role in Alzheimer ' s disease , a study comparing promoter function of an interleukin-1A polymorphism was performed in the SVG astroglia cell line . - pubmed
As discussed , BRIN - BD11 cells have facilitated studies aimed at dissecting important pathways by which nutrients and other bioactive molecules regulate the complex mechanisms regulating insulin secretion , and highlight the future potential of novel and diverse bioengineering approaches to provide a cell - based insulin - replacement therapy for diabetes . - pubmed
Clonal BRIN - BD11 beta - cells have been instrumental in : ( a ) characterization of K ( ATP ) channel - dependent and -independent actions of nutrients and established and emerging insulinotropic antidiabetic drugs , and the understanding of drug - induced beta - cell desensitization ; ( b ) tracing novel metabolic and beta - cell secretory pathways , including use of state - of - the - art NMR approaches to provide new insights into the relationships between glucose and amino acid handling and insulin secretion ; and ( c ) determination of the chronic detrimental actions of nutrients and the diabetic environment on pancreatic beta - cells , including the recent discovery that homocysteine , a risk factor for metabolic syndrome , may play a role in the progressive demise of insulin secretion and pancreatic beta - cell function in diabetes . - pubmed
Arginine rich , mutated in early stage of tumors ( ARMET ) was first identified as a human gene highly mutated in a variety of cancers . - pubmed
To design a practical approach for a molecular diagnosis of micrometastasis , we applied direct DNA sequencing to screen 48 early stage colorectal carcinomas for the most frequent mutations of the KRAS , P53 , and APC tumor genes . - pubmed
In contrast , the frequency of P53 and APC hot spot mutations was unexpectedly low , compared with previous studies using other screening methods or including advanced tumor stages . - pubmed
Applying mutant - enriched polymerase chain reaction ( PCR ) , the mutation of the primary tumor was detected in lymph node DNA from 2 of the KRAS - positive patients . - pubmed
Second case of Beare - Stevenson syndrome with an FGFR2 Ser372Cys mutation . - pubmed
[ Dysfunctions of potassium channels and Parkinson ' s disease ] . - pubmed
Dose - dependent thrombus resolution due to oral plaminogen activator inhibitor ( PAI )- 1 inhibition with tiplaxtinin in a rat stenosis model of venous thrombosis . - pubmed
This study aimed to evaluate a small - molecule PAI-1 inhibitor ( PAI-039 ; tiplaxtinin ) in a rodent stenosis model of venous thrombosis in a two - phase experiment . - pubmed
Phase 1 animals ( n = 24 ) receiving low - dose ( LD ; 1 mg / kg oral gavage ) PAI-1 inhibitor demonstrated a 52 % decrease in thrombus weight ( TW ) versus controls ( p & lt ; 0.05 ) with significant reductions in active plasma PAI-1 , while the high - dose ( HD ; 10 mg / kg oral gavage ) group demonstrated a 23 % reduction in TW versus controls . - pubmed
Insulin secretion in metabolically obese , but normal weight , and in metabolically healthy but obese individuals . - pubmed
Additionally , metabolically healthy but obese ( MHO ) individuals have been identified who are relatively insulin sensitive and have a favorable cardiovascular risk profile . - pubmed
We compared insulin secretion patterns of MONW and MHO with those of two age - matched groups comprising nonobese individuals or obese insulin - resistant subjects , respectively . - pubmed
To this end , 110 nonobese subjects and 87 obese subjects were stratified into quartile based on their insulin - stimulated glucose disposal ( M(FFM ) ) . - pubmed
Disposition index did not differ between MONW and insulin - resistant obese . - pubmed
M(FFM ) was higher in MHO who exhibited lower waist circumference , blood pressure ( BP ) , triglycerides , FFA , insulin levels , and higher high - density lipoprotein ( HDL ) cholesterol compared to insulin - resistant obese . - pubmed
Insulin secretion did not differ between insulin - resistant obese and MHO , but disposition index was lower in the former group . - pubmed
In conclusion , MONW and insulin - resistant obese showed decreased compensatory insulin secretion compared to normal nonobese and MHO subjects , respectively . - pubmed
We found that the formation of yolk sac hemogenic endothelium and its hematopoietic potential were significantly impaired in the absence of retinoic acid ( RA ) signaling , and could be restored in RA - deficient ( Raldh2(-/- ) ) embryos by provision of exogenous RA in utero . - pubmed
Hepatocyte growth factor activator inhibitor-2 ( HAI-2 ) is a favorable prognosis marker and inhibits cell growth through the apoptotic pathway in cervical cancer . - pubmed
We investigated the role of hepatocyte growth factor activator inhibitor-2 ( HAI-2 ) and evaluated its clinical importance in cervical cancer . - pubmed
PATIENTS AND METHODS : HAI-2 expression was examined in cervical cancer specimens ( n=52 ) by immunohistochemistry . - pubmed
We further attempted to investigate the biological functions and inhibitory effects of HAI-2 using human papillomavirus ( HPV ) 16 type SiHa and HPV 18 type HeLa cervical cancer cell lines . - pubmed
CONCLUSIONS : The present findings indicate that low HAI-2 expression in cervical cancer may be associated with a poor prognosis . - pubmed
We propose that HAI-2 may represent a therapeutic target for the treatment of cervical cancer . - pubmed
Anemia should , therefore , be considered as a useful prognosticator , and therapeutic strategies aimed to increase hemoglobin levels in CHF should be investigated . - pubmed
CONCLUSION : It can be inferred that : ( i ) IL-12 profiles alone may represent a relevant indicator of heavy metal - induced immune modulation ; ( ii ) evaluating cytokine profiles by CBA is relevant and can adequately replace other methods such as ELISA and RT - PCR in basic research as well as in immune diagnostics ; and ( iii ) targeting IL-12 in therapeutic approaches may be promising to modify Th1 / Th2 - associated immune disorders . - pubmed
The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer . - pubmed
This study compares Breast Cancer 1 ( BRCA1 ) and excision repair cross complementation group 1 ( ERCC1 ) expression as predictive markers and evaluates the in vitro enhancement of platinum sensitivity using targeted agents in sporadic ovarian cancer ( OC ) . - pubmed
High BRCA1 was predictive of poorer OS specifically in patients with residual disease ( RD ) & lt;2 cm ( p = 0.03 ) . - pubmed
In summary , this study shows that low BRCA1 and ERCC1 expression correlate with improved survival in advanced OC and HDAC inhibition induces synergistic cytotoxicity with platinum in vitro . - pubmed
The role of CX3CR1 , a chemokine receptor expressed in microglia , in regulating microglia morphology and dynamic behavior in the resting state and after laser - induced focal injury was examined . - pubmed
CX3CL1 signaling from retinal neurons and endothelial cells likely modulates dynamic microglia behavior so as to influence the level of microglial surveillance under basal conditions and the rate of dynamic behavior in response to tissue injury . - pubmed
Age - related loss of phospholipid asymmetry in APP(NLh)/APP(NLh ) x PS-1(P264L)/PS-1(P264L ) human double mutant knock - in mice : relevance to Alzheimer disease . - pubmed
Using APP(NLh)/APP(NLh ) x PS-1(P246L)/PS-1(P246L ) human double knock - in ( APP / PS-1 ) mice , we examined whether phosphatidylserine ( PtdSer ) asymmetry is significantly altered in brain of this familial Alzheimer disease mouse model in an age - dependent manner as a result of oxidative stress , toxic Abeta(1 - 42 ) oligomer production , and/or apoptosis . - pubmed
We postulated that a tumor suppressor present in mammals but absent in regenerative vertebrates , the Ink4a product ARF ( alternative reading frame ) , is a regeneration suppressor . - pubmed
Targeting of alpha - hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model . - pubmed
We tested the hypothesis that alpha - hemolysin ( Hla ) contributes to the severity of USA300 skin infections in mice and determined whether vaccination against Hla reduces disease severity . - pubmed
Passive immunization with Hla - specific antisera or active immunization with a nontoxigenic form of Hla significantly reduced the size of skin lesions caused by USA300 and prevented dermonecrosis . - pubmed
ACE inhibitors for the treatment of hypertension drug selection by means of the SOJA method . - pubmed
ACE inhibitors have proven to be effective blood pressure lowering agents with an excellent tolerability profile . - pubmed
Tumor cells coexpressed EMA and GLUT-1 , and a minority immunoreacted for smooth muscle actin . - pubmed
METHODOLOGY / PRINCIPAL FINDINGS : Here we addressed whether NK cells have the potential to control chronic myeloid leukemia ( CML ) arising based on the transplantation of BCR - ABL1 oncogene expressing primary bone marrow precursor cells into lethally irradiated recipient mice . - pubmed
Since the presence of NK cells reduced the abundance of leukemia propagating cancer stem cells , the data raise the possibility that NK cell recognition has the potential to cure CML , which may be difficult using small molecule BCR - ABL1 inhibitors . - pubmed
Finally , our findings validate approaches to treat leukemia using antibody - based blockade of self - specific inhibitory MHC class I receptors . - pubmed
In murine experimental colitis in - vivo , myeloperoxidase activity decreased significantly in 2,4,6 - trinitrobenzenesulfonic acid ( TNBS)-colitis and oxazolone ( OXA)-colitis models after treatment with ClNP while free clodronate did not show a mitigating effect . - pubmed
Similarly , alkaline phosphatase could be lowered significantly from 12.5 + -1.9 to 6.8 + -2.2ng / mg tissue in TNBS - colitis and from 16.6 + -6.2 to 11.8 + -2.7ng / mg tissue in OXA - colitis . - pubmed
Our work also provides important insights in disease like Robinow syndrome , brachydactyly type B1 ( BDB1 ) and spina bifida , which can be caused by human mutations in the Wnt / PCP signaling pathway . - pubmed
When serum from a 6 week clinical intervention with dietary supplements containing olive oil ( control ) , DHA , or two levels of EPA were applied to THP-1 cells , the expression of SCD and FADS2 decreased in the cells treated with serum from the omega3 - PUFA - supplemented individuals . - pubmed
G Protein beta3 subunit gene C825 T polymorphism and its association with the presence and clinicopathological characteristics of prostate cancer . - pubmed
We investigated the possible association of GNB3 gene polymorphism with prostate cancer and its clinicopathological characteristics . - pubmed
RESULTS : The frequency of the GNB3 825 T allele in patients with prostate cancer was significantly higher than in controls ( 49.1 % vs 42.7 % , OR 3.76 , p = 0.003 ) . - pubmed
Men lacking the C825 allele were at approximately sevenfold higher risk for high grade ( Gleason score greater than 7 ) prostate cancer than men with the GNB3 CC genotype . - pubmed
CONCLUSIONS : Our study presents preliminary but intriguing data suggesting that GNB3 gene polymorphism influences susceptibility to prostate cancer . - pubmed
A new Cylindromatosis ( CYLD ) gene mutation in a case of Brooke - Spiegler syndrome masquerading as basal cell carcinoma of the eyelids . - pubmed
Although the exact etiology and pathogenesis of EoE remain unclear , it is now generally accepted that it is the result of a T - helper cell 2 - type immune response with a crucial role for the eosinophil - specific chemotaxis factor eotaxin 3 and eosinophils . - pubmed
(1 ) T(H)1 produce interferon - gamma ( IFNgamma ) and are important for protective immune responses to intracellular viral , bacterial and parasitic infection . - pubmed
Serum calcium level , fasting blood glucose level ( FBG ) , hexokinase activity , glucose-6 - phosphatse and fructose 1,6 bisphosphatase activity were measured to establish a relevant correlation between vitamin D supplementation and hyperglycemia in T2DM . - pubmed
The activity of the glucose metabolic enzymes was also assayed in diabetic group and was found to be deviated from control group ; hexokinase ( 0.0241 + - 0.014 mug / mg / ml ) FBPase ( 0.433 + - 0.002 mug / mg / ml ) and G6Pase ( 0.918 + - 0.02 mug / mg / ml ) . - pubmed
Besides , the activity of various glucose metabolic enzymes ( hexokinase , FBPase and G6Pase ) as shown by our results and the remarkable shortening of DNA tail length in vitamin D supplemented diabetic group as compared to diabetic group without supplementation further support the idea that vitamin D supplementation might be an add - on therapy for patients with T2DM . - pubmed
[ Protective effects of SUR2B / Kir6.1 potassium channel opener natakalim against RAVECs injuries induced by hypoxia ] . - pubmed
RESULTS : Natakalim could reverse hypoxia - induced changes in endothelial cell function , including increased endothelial cell survival rate and level of NO concentration , significantly inhibited the hypoxia - induced endothelial ICAM-1 , ET-1 , VEGF mRNA expression levels increased . - pubmed
CONCLUSION : Natakalim have protective effects on hypoxia - induced changes in endothelial cell function , increasing of permeation , excess expression of cell adhesion molecules . - pubmed
In vivo , the results showed that CPs could not only inhibit the growth of the tumor , but also enhance the spleen index , as well as the level of IL-2 , IFN - gamma and TNF - alpha . - pubmed
The protein p53 functions as a tumor suppressor and can trigger either cell cycle arrest or apoptosis in response to DNA damage . - pubmed
Attractor landscape analysis of the cellular response to DNA damage of the breast cancer cell line MCF7 and the effect of the Mdm2 ( murine double minute 2 ) inhibitor nutlin-3 indicated that nutlin-3 would exhibit limited efficacy in triggering cell death , because the cell death state was not induced to a large extent by simulations with nutlin-3 and instead produced a state consistent with oscillatory p53 dynamics and cell cycle arrest . - pubmed
Thus , attractor landscape analysis of p53 network dynamics and its regulation can identify potential therapeutic strategies for treating cancer . - pubmed
To assess the prevalence of specific IgE in electrophoretically separated ragweed pollen proteins , individual reactivity of sera from dogs with CAD was analyzed and compared to the reactivity of sera from healthy dogs in the non - reducing conditions , which were found optimal for specific canine IgE detection . - pubmed
A specific IgE band ( 38 kDa ) was recognized as the most dominant allergen in CAD , occurring in 81 % of positive dog 's sera . - pubmed
2 - D immunoblotting followed by a mass spectrometry peptide fingerprint analyses with pooled canine and human atopic sera , revealed that 38 kDa major Ambrosia atremisiifolia allergens in CAD were all five isoallergens of the Amb a 1 group ( antigen E ) , including the previously named Amb a 2 ( antigen K ) . - pubmed
The most prominent ragweed proteins in CAD , represent , as in humans , variants of all five isoallergens of the Amb a 1 group ( pectate lyase ): Amb a 1.0101 and its natural variant E1XUL2 , Amb a 1.0202 , 1.0304 , 1.0402 and the natural variant of Amb a 1.0501 , E1XUM0 , as well as the alpha fragment of pollen allergen Amb a 1.0201 . - pubmed
Biologically , the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells . - pubmed
In a mouse tumor xenograft model , the complex was shown to be delivered efficiently to tumor tissue , downregulating expression of LMP1 and suppressing tumor growth . - pubmed
In studying dyslipidemia in Pakistan , hypertriglyceridemia is found in 27 - 54 % of the population , whereas 68 - 81 % has low levels of high - density lipoprotein ( HDL ) . - pubmed
Shank mutant mice as an animal model of autism . - pubmed
In this review , we focus on the role of the Shank family of proteins in autism . - pubmed
Here , we analyse studies that relate Shank to autism and discuss what light this sheds on the possible causes of autism . - pubmed
Concomitance of IgM and IgG anti - dsDNA Antibodies Does Not Appear to Associate to Active Lupus Nephritis . - pubmed
Previous reports proposed that the IgM anti - dsDNA antibody is protective for lupus nephritis . - pubmed
In this cross - sectional study , we aimed to compare clinical features of systemic lupus erythematosus ( SLE ) patients positive for IgG anti - dsDNA alone with those presenting both IgG and IgM anti - dsDNA . - pubmed
Fifty - eight SLE patients ( 93.1 % female , 81 % European - derived , mean age 42.8 + -14.7 years , mean duration of disease 10.9 + -8 years ) positive for IgG anti - dsDNA entered the study . - pubmed
The group with both isotypes showed significant less frequency of active nephritis ( sediment changes and proteinuria ) when compared to patients with IgG anti - dsDNA alone ( 6.7 % versus 34.9 % , p=0.046 ) . - pubmed
These data suggest a nephroprotective role for IgM anti - dsDNA and a distinct biologic behavior for this isotype in SLE . - pubmed
In food allergies , especially in type I allergic reactions , dietary fat can modulate the development of clinical symptoms through influencing the production of immunoglobulins ( Ig ) , cytokines and chemical mediators . - pubmed
Renin - angiotensin system genetic polymorphisms and brain white matter lesions in older Australians . - pubmed
The associations of single nucleotide polymorphisms ( SNPs ) in the genes encoding angiotensinogen ( AGT , rs699 ) , angiotensin - converting enzyme ( ACE , rs4362 ) , and angiotensin II receptor type 1 ( AGTR1 , rs5182 ) with WMLs were examined . - pubmed
When the cohort was stratified by sex , ACE rs4362 and AGT rs699 showed significant associations with WMLs in men only ( P = 0.01 and P = 0.03 , respectively ) , and remained significant after controlling for hypertension . - pubmed
Although the AGTR1 SNP did not show any association with WMLs , the interaction of the AGT rs699 and AGTR1 rs5182 SNPs with WMLs was significant before ( P = 0.03 ) and after adjustment for hypertension ( P = 0.045 ) . - pubmed
CONCLUSIONS : The results provide evidence for association of polymorphisms in the renin - angiotensin system genes with WMLs , independent of hypertension . - pubmed
Male - only associations with WMLs were found for the AGT rs699 and ACE rs362 polymorphisms . - pubmed
Moreover , for the entire sample an interaction between AGT and AGTR1 rs5182 genotypes on WMLs was observed . - pubmed
Prescriptions for long - term management varied among districts , as follows : inhaled corticosteroids ( ICS ) , mean of 37.3 % ( 0 - 66.7 % ) ; ICS / long - acting beta - agonists ( LABA ) , 27.9 % ( 16.7 - 66.7 % ) ; and leukotriene receptor antagonist ( LTRA ) , 20.5 % ( 0 - 50.0 % ) CONCLUSION : These findings suggest that asthma treatment in emergency settings varies by facility and region . - pubmed
At the age of 4 mo , he was diagnosed as having CNDI , judging from fever with hypernatremia ( serum Na 153 mEq / L ) , diluted urine ( urine osmolarity 193 mOsm / kg ) , high antidiuretic hormone ( plasma antidiuretic hormone 53 pg / mL ) , and normal renal function ( serum creatinine 0.3 mg / dL ) . - pubmed
BACKGROUND : Thymic stromal lymphoproetin ( TSLP ) is a cytokine secreted by the airway epithelium in response to respiratory viruses and it is known to promote allergic Th2 responses in asthma . - pubmed
This study investigated whether virally - induced secretion of TSLP is directional in nature ( apical vs. basolateral ) and/or if there are TSLP - mediated effects occurring at both sides of the bronchial epithelial barrier in the asthmatic state . - pubmed
METHODS : Primary human bronchial epithelial cells ( HBEC ) from control ( n = 3 ) and asthmatic ( n = 3 ) donors were differentiated into polarized respiratory tract epithelium under air - liquid interface ( ALI ) conditions and treated apically with dsRNA ( viral surrogate ) or TSLP . - pubmed
Sub - epithelial effects of TSLP were examined in human airway smooth muscle cells ( HASMC ) from normal ( n = 3 ) and asthmatic ( n = 3 ) donors . - pubmed
RESULTS : Our data demonstrate that : 1 ) Asthmatic HBEC exhibit an exaggerated apical , but not basal , secretion of TSLP after dsRNA exposure ; 2 ) TSLP exposure induces unidirectional ( apical ) secretion of CCL11 / eotaxin-1 in asthmatic HBEC and enhanced CCL11 / eotaxin-1 secretion in asthmatic HASMC ; 3 ) Rhinovirus - induced asthma exacerbations in children are associated with in vivo airway secretion of TSLP and CCL11 / eotaxin-1 . - pubmed
CONCLUSIONS : There are virally - induced TSLP - driven secretory immune responses at both sides of the bronchial epithelial barrier characterized by enhanced CCL11 / eotaxin-1 secretion in asthmatic airways . - pubmed
The effect of simvastatin on inflammatory cytokines in community - acquired pneumonia : a randomised , double - blind , placebo - controlled trial . - pubmed
OBJECTIVES : It has been suggested that statins have an effect on the modulation of the cytokine cascade and on the outcome of patients with community - acquired pneumonia ( CAP ) . - pubmed
The aim of this prospective , randomised , double - blind , placebo - controlled trial was to determine whether statin therapy given to hospitalised patients with CAP improves clinical outcomes and reduces the concentration of inflammatory cytokines . - pubmed
CONCLUSIONS : Our results suggest that the use of simvastatin , 20 mg once daily for 4 days , since hospital admission did not reduce the time to clinical stability and the levels of inflammatory cytokines in hospitalised patients with CAP . - pubmed
Some of the target compounds exhibited moderate to excellent mTOR / PI3Kalpha kinase inhibitory activity and cytotoxicity . - pubmed
PLAC8 was highly expressed in GDM - exposed ECFCs , and PLAC8 expression correlated with maternal hyperglycemia . - pubmed
We found that autophagic vacuoles and SQSTM1 - positive proteins accumulated in TECs from patients with DN and in human renal tubular epithelial cell line ( HK-2 cells ) treated with advanced glycation end products ( AGEs ) , the important factors that involved in the pathogenesis of DN . - pubmed
Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression - like phenotypes in mice . - pubmed
As a consequence , PP2A inhibition ameliorates depression - like symptoms after FsE and in a learned - helplessness model of depression . - pubmed
Furthermore , its reversal by PP2A inhibition may provide a novel therapeutic approach to alleviate symptoms of depression in disorders that are characterized by LHb hyperactivity . - pubmed
Copy Number Variations of the Azoospermia Factor Region and SRY Are Not Associated with the Risk of Hypospadias . - pubmed
We analyzed the copy number of the azoospermia factor ( AZF ) region and SRY , using multiplex ligation - dependent probe amplification . - pubmed
The results imply that CNVs in the AZF region and SRY are not associated with the risk of hypospadias in the Japanese population , although the pathogenicity of the AZF - linked simple duplication remains to be elucidated . - pubmed
This phenomenon was initially attributed to different gr / gr subtypes that would eliminate distinct members of the affected gene families . - pubmed
Hepatocyte growth factor promotes proliferation , invasion , and metastasis of myeloid leukemia cells through PI3K - AKT and MAPK / ERK signaling pathway . - pubmed
HGF and c - Met expression in first - vist AML group was significantly higher than in AML - relief and normal control group . - pubmed
In conclusion , HGF and c - Met gene highly expressed among first - visit AML patients , but decreased after relief treatment . - pubmed
HGF may promote proliferation , invasion , and metastasis of AML cells through PI3K - AKT and MAPK / ERK signaling pathway . - pubmed
Therefore , proliferation and invasion ability of AML cell can be inhibited by down - regulating HGF gene to retardate cell in G2 / M stage . - pubmed
A consistent inhibitory effect of ticagrelor 60 mg bid was observed pre- and post - dose regardless of diabetes status , even in insulin - treated patients . - pubmed
For laboratory evaluation , cholestasis parameters ( bilirubin , gamma - GT ) , liver cell parameters ( ASAT , ALAT ) and liver synthesis parameters ( quick , albumin ) were determined . - pubmed
Furthermore , we used the mRNA of IL-33 , GADD45a and p-21 for analyzing cellular stress and regeneration in cholestatic rats . - pubmed
RESULTS : In chemical laboratory and histological evaluation , a distinction between acute and chronic cholestatic liver injury with identification of inflammation and regeneration could be demonstrated by an increase in cholestasis ( bilirubin : 1 - wk group , 156.83 + - 34.12 mumol / L , P = 0.004 ) and liver cell parameters ( ASAT : 2 - wk group , 2.1 + - 2.19 mumol / L.s , P = 0.03 ; ALAT : 2 - wk group , 1.03 + - 0.38 mumol / L.s , P = 0.03 ) after bile duct ligation ( BDL ) . - pubmed
Furthermore , the inflammation could be verified by ASDCL ( 4 - wk group , 22 + - 5.93 positive cells per portal field , P = 0.041 ) and HMGB-1 [ 2 - wk group , 13 + - 8.18 positive cells per field of view ( FoV ) , P = 0.065 ] staining . - pubmed
Additionally , to establish the chronic cholestasis model , we evaluated liver regeneration capacity through measurements of IL-33 , p-21 and GADD45a mRNA . - pubmed
Procalcitonin , erythrocyte sedimentation rate and C - reactive protein in acute pulmonary exacerbations of cystic fibrosis . - pubmed
CONCLUSIONS : ESR and CRP are useful markers for CF exacerbations , as levels rise with exacerbations . - pubmed
Baseline elevations in ESR and CRP were noted to show an increased risk for CF exacerbations . - pubmed
EFFECT OF LEPTIN ON THE GALLBLADDER IN PATIENTS WITH METABOLIC SYNDROME . - pubmed
It was shown that leptin level in CNC patients with MS was 2.61 times that in healthy subjects ( p & lt;0.001 ) and 2.47 times higher than in CNC patients without MS ( p & lt;0.001 ) . - pubmed
Defects in mismatch repair : the Achilles heel of estrogen receptor positive breast cancer with intrinsic endocrine therapy resistance ? - pubmed
Exenatide Inhibits the KCa3.1 Channels of Aortic Vascular Smooth Muscle in Diabetic Rats . - pubmed
Background : KCa3.1 ion channels play an important role during atherosclerosis . - pubmed
We aimed to investigate the effect of exenatide on KCa3.1 expression in aortic vascular smooth muscle cells ( VSMCs ) of diabetic rats . - pubmed
Results : Aortic tissue staining in the DM group revealed an absence of smooth or integrated endothelium , increased smooth muscle cell proliferation in the media , smooth muscle hyperplasia , disorganized smooth muscle cells , and an increased number of collagen fibers , relative to the NC and ET groups . - pubmed
KCa3.1 mRNA expression was higher in the DM group than in the NC and ET groups . - pubmed
Similarly , the KCa3.1 protein level was higher in the DM group than in the NC and ET groups . - pubmed
Conclusions : Exenatide could inhibit the expression of the KCa3.1 channel in VSMCs of diabetic rats . - pubmed
We also identified 18 targeting genes by super - enhancers with prognostic significance for ovarian cancer , such as the tumour suppressor CDKN1B. - pubmed
Although the exact mechanism of the development of ovarian cysts is unknown , it is thought that increased androgen levels stimulate folicle development by increasing follicle stimulating hormone ( FSH ) levels . - pubmed
Cadmium disrupts signaling of the hypoxia - inducible ( HIF ) and transforming growth factor ( TGF - beta ) pathways in placental JEG-3 trophoblast cells via reactive oxygen species . - pubmed
While a precise mechanism is unknown , oxidative imbalance and dysregulation of the hypoxia inducible factor ( HIF ) and transforming growth factor beta ( TGF - beta ) pathways have been implicated in placental disease pathogenesis . - pubmed
In addition to describing how to perform the EEG - ECG recordings , we also detail methods to quantify the resulting data for seizures , EEG spectral power , cardiac function , and heart rate variability , which we demonstrate in an example experiment using a mouse with epilepsy due to Kcna1 gene deletion . - pubmed
As observed in cancer patients , we found that mTOR , a key signalling molecule responsible for maintaining cell growth and autophagy was suppressed in this model . - pubmed
Tumor bearing mice hearts show increased expression and nuclear localization of TFEB and FoxO3a transcription factors , which are involved in the upregulation of muscle atrophy genes , lysosomal biogenesis genes and autophagy genes . - pubmed
CYP2D6 genotype and endoxifen plasma concentration do not predict hot flash severity during tamoxifen therapy . - pubmed
There is paucity of prospectively collected data in terms of CYP2D6 genotype and measured tamoxifen , 4 - hydroxytamoxifen and endoxifen concentrations in relation to hot flash severity during tamoxifen therapy . - pubmed
Genetic variation in CYP2D6 or CYP3A4 was not predictive of hot flash severity . - pubmed
Ertugliflozin is a highly selective inhibitor of SGLT2 , and was approved in the US for the treatment of adults with T2DM . - pubmed
Advantages of ertugliflozin include reduction in glycated hemoglobin , weight loss and blood pressure lowering with a low risk of hypoglycemia . - pubmed
Objective : To investigate the attainment of therapeutic targets for glycosylated hemoglobin and blood pressure , ophthalmologic examination , diagnosis and treatment of diabetic retinopathy ( DR ) with type 2 diabetes mellitus . - pubmed
Conclusions : The investigation of the type 2 diabetic patients in a community of Fushun indicated that more than 60 % of patients did not attain therapeutic targets for glycosylated hemoglobin , and 70 % for blood pressure ; 78 % had not received ophthalmologic examination after the diagnosis of diabetes mellitus ; 82 % of vision - threatening DR patients had not been treated . - pubmed
Anti - epidermal growth factor receptor ( EGFR ) monoclonal antibody combined with cisplatin and 5 - fluorouracil in patients with metastatic nasopharyngeal carcinoma after radical radiotherapy : a multicentre , open - label , phase II clinical trial . - pubmed
BACKGROUND : We conducted a single - arm phase II trial to evaluate the efficacy and adverse effects ( AEs ) of an anti - epidermal growth factor receptor monoclonal antibody , nimotuzumab , combined with cisplatin and 5 - fluorouracil ( PF ) as first - line treatment in recurrent metastatic nasopharyngeal carcinoma after radical radiotherapy . - pubmed
, against myeloperoxidase or proteinase-3 ) and systemic lupus erythematosus ( SLE ) ( i.e. - pubmed
Immunologic congenital atrioventricular block is due to the presence of anti - SSA and anti - SSB antibodies in maternal blood . - pubmed
RESULTS : The carcinoembryonic antigen level before treatment , postoperative complications , pathology after neo - adjuvant therapy ( ypT , ypN ) , lymphatic invasion , venous invasion and pathological response of the primary tumor were significant factors in a comparison of patients with and without early recurrence . - pubmed
Expression of gamma - H2AX and patient prognosis in breast cancer cohort . - pubmed
In the present study , we assessed the gamma - H2AX expression , its association with other clinicopathologic characteristics , and the prognosis in a cohort of 97 patients with breast cancer . - pubmed
The positive rates of H2AX were 26.0 % and 2.6 % in tumor tissue and adjacent normal tissues , respectively . - pubmed
gamma - H2AX expression could be a potential biomarker for cancer diagnosis and prediction , and further studies are in need . - pubmed
Expression of prostaglandin E2 receptor 3 in the eyelid epidermis of patients with Stevens - Johnson syndrome / toxic epidermal necrolysis . - pubmed
BACKGROUND / AIMS : In a previous genome - wide association study of Stevens - Johnson syndrome / toxic epidermal necrolysis ( SJS / TEN ) patients we reported the association between SJS / TEN and the prostaglandin E receptor 3 ( PTGER3 ) gene , and that its protein PGE2 receptor 3 ( EP3 ) was markedly downregulated in the conjunctival epithelium of SJS / TEN patients . - pubmed
Here we examined EP3 expression of the eyelid epidermis in SJS / TEN patients with severe ocular complications and investigated the function of EP3 . - pubmed
METHODS : For the immunohistochemical study , we obtained eyelid samples from five SJS / TEN patients and five patients without SJS / TEN ( control subjects ) who were undergoing surgery to treat trichiasis , and investigated the expression of EP3 protein in the epidermis of those samples . - pubmed
RESULTS : The results of the immunohistochemical study revealed that EP3 expression in the eyelid epidermis of the SJS / TEN patients was the same as that in the controls . - pubmed
CONCLUSION : Our findings revealed that in chronic - phase SJS / TEN , EP3 protein was expressed in the eyelid epidermis and was not downregulated , unlike in conjunctival epithelium , and that PGE2 could suppress cytokine production via EP3 in human epidermal keratinocytes . - pubmed
Thus , EP3 expression in the epidermis might contribute to a silencing of skin inflammation in chronic - phase SJS / TEN . - pubmed
Here , we describe a novel liposome - based subunit vaccine formulation for tuberculosis ( TB ) based on phosphatidylserine encapsulating two prominent TB antigens , Ag85B , and ESAT-6 . - pubmed
The postnatal presence of human chorionic gonadotropin in preterm infants and its potential inverse association with retinopathy of prematurity . - pubmed
We analyzed hCG and LH blood levels at 1 week and 4 weeks of age from 113 study participants ( 60 without ROP ; 53 with non - proliferative ROP ) . - pubmed
RESULTS : Similar levels of hCG are found in preterm infants at both 1 week and 4 weeks after birth . - pubmed
Preterm infants with non - proliferative ROP , after adjusting for sex and gestational age , have 2.42 [ 95 % CI : 1.08 - 5.40 ] times the odds of having low hCG at fourth week of age . - pubmed
CONCLUSIONS : We found that hCG is present postnatally in preterm infants and that a deficiency of hCG at 4 weeks of age is potentially associated with non - proliferative ROP . - pubmed
IL-8 gene locus is associated with risk , severity and 28 - day mortality of sepsis in a Chinese population . - pubmed
Interleukin ( IL )- 8 has been reported to be associated with the progression of sepsis . - pubmed
Recent studies have explored the relationship between the IL-8 - 251 A / T polymorphism and sepsis risk . - pubmed
This study evaluated the association between the IL-8 - 251 A / T polymorphism and sepsis susceptibility in a Chinese Han population . - pubmed
This study showed that the IL-8 - 251 A / T polymorphism was associated with a decreased risk of sepsis . - pubmed
The IL-8 - 251 A / T polymorphism was also related to the severity and 28 - day mortality of sepsis . - pubmed
The IL-8 - 251 A / T polymorphism is associated with a decreased risk of sepsis . - pubmed
Creutzfeldt - Jakob disease ( CJD ) is characterized by a rapidly progressive dementia often accompanied by myoclonus and other signs of brain dysfunction , relying on the conversion of the normal cellular form of the prion protein ( PrPC ) to a misfolded form ( PrPSc ) . - pubmed
Moreover , its two important executioners , the gasdermin D ( GSDMD ) and gasdermin E ( GSDME ) , and the functions and mechanisms of them in the regulation in cancer therapy were focused on . - pubmed
Clinical presentation and differential splicing of SRSF2 , U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia . - pubmed
Oral prednisolone was administered on day 33 then fever subsided with dramatically clinical improvement ( decreased CRP and resolution of lung consolidation ) . - pubmed
Together , these results suggest that the effect of RES in treatment of DN may involve AMPK alpha / mTOR - mediated autophagy . - pubmed
Recent highlights include use of antibody - dependent cellular cytotoxicity - sensitizing CD4 - induced mimetic compounds , novel V1V2 immunogens , passive transfer studies , and vaccine regimens that successfully elicited Fc - mediated responses and were reported to decrease risk of infection in challenge studies in NHPs . - pubmed
New studies continue to highlight the importance of Fc - mediated antibody responses as correlates of decreased risk of infection and suggest enhanced phagocytosis is a potential mechanism of reduced risk of infection associated with human IgG3 responses . - pubmed
Parkinson ' s disease ( PD ) is the most frequent of all Lewy body diseases , a family of progressive neurodegenerative disorders characterized by intra - neuronal cytoplasmic inclusions of alpha - synuclein . - pubmed
[ A case of Alexander disease presented with dystonia of lower limb and decreased dopaminergic uptake in dopamine transporter scintigraphy ] . - pubmed
Soluble forms of PD - L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinoma . - pubmed
Metastatic clear cell renal cell carcinoma ( mccRCC ) benefits from several treatment options in the first - line setting with VEGFR inhibitors and/or immunotherapy including anti - PD - L1 or anti - PD1 agents . - pubmed
Therefore , we evaluated soluble forms of PD - L1 ( sPD - L1 ) and PD-1 ( sPD-1 ) in mccRCC patients . - pubmed
The levels of sPD - L1 and sPD-1 were evaluated from plasma samples of mccRCC patients before they received a first - line treatment ( T0 ) by the VEGFR inhibitor sunitinib ( 50 patients ) or by the anti - VEGF bevacizumab ( 37 patients ) . - pubmed
mccRCC patients with high plasmatic levels of sPD - L1 or sPD-1 are poor responders to sunitinib . - pubmed
Reduced numbers of T cells with Fc receptors for IgG ( TG cells ) are present in blood samples of patients with respiratory allergic disease , mainly those with severe symptoms . - pubmed
Dog mastocytoma cells produce transforming growth factor beta 1 . - pubmed
We report here the constitutive production of TGF beta 1 by four dog mastocytoma cell lines . - pubmed
Quantitation by bioassay revealed baseline TGF beta secretion of approximately 1 ng/10(6 ) cells over 48 h. Stimulation of mastocytoma cells with phorbol ester increased the rate of release of TGF beta 1 , most markedly in the first 30 min after stimulation , without increasing TGF beta 1 mRNA . - pubmed
Dog mastocytoma cells produced TGF beta 1 primarily in a latent form , inactive until treated with acid . - pubmed
Both pure TGF beta 1 and TGF beta - containing mastocytoma cell - conditioned media inhibited mitogenesis and proliferation in dog mastocytoma cell lines , suggesting that mast cell tumor lines would not grow preferentially based on their ability to produce TGF beta . - pubmed
The growth promoting effect of several hormones and growth factors on two human colon tumor cell lines ( Caco-2 and SW 48 ) was studied using six different chemically defined serum - free media ( SFM ) . - pubmed
The method is demonstrated by localization of insulin - like growth factor II ( IGF - II ) mRNA in human intracranial tumours and foetal brain . - pubmed
Five of 10 meningiomas expressed IGF - II mRNA to an extent of 1 % of their tumour cells and two of three pituitary adenomas exhibited a less than 0.2 % IGF - II mRNA - positive cell population . - pubmed
IGF - II may be important in the progression and/or maintenance of these tumours . - pubmed
Tissue levels of adenosine triphosphate ( a major tissue energy store ) , superoxide dismutase ( a major defense against free radicals ) , xanthine oxidase ( an enzymatic source of free radicals ) , and edema were measured . - pubmed
Expression of c - fos in parietal endoderm , amnion and differentiating F9 teratocarcinoma cells . - pubmed
Among these activities the production of proteases could obviously influence tumor cell detachment and migration from the primary . - pubmed
We have evaluated the expression of plasminogen activator ( PA ) in different types of murine tumors with differing immunogenic capacity . - pubmed
In TAM from all tumors studied the expression of PA was markedly greater than that of resident peritoneal macrophages . - pubmed
Hypomyelination in border disease : the roles of thyroid hormones , growth hormone , and virus infection of the CNS . - pubmed
Immunoglobulin allotypes in patients with giant cell arteritis and polymyalgia rheumatica . - pubmed
We conclude that some patients with PPS have in the serum high titers of IgM anti - PV antibodies , implying an ongoing antibody response to a viral antigen . - pubmed
Structure - function analysis of human glucose-6 - phosphatase , the enzyme deficient in glycogen storage disease type 1a . - pubmed
Glucose-6 - phosphatase ( G6Pase ) is the enzyme deficient in glycogen storage disease type 1a , an autosomal recessive disorder . - pubmed
We have previously identified six mutations in the G6Pase gene of glycogen storage disease type 1a patients and demonstrated that these mutations abolished or greatly reduced enzymatic activity of G6Pase , a hydrophobic protein of 357 amino acids . - pubmed
Refining the localization of the PKD2 locus on chromosome 4q by linkage analysis in Spanish families with autosomal dominant polycystic kidney disease type 2 . - pubmed
To test this possibility , we introduced a transgene directing lymphoid expression of IL-7 into nude mice and found that it substantially alleviates the block in T cell maturation caused by the thymic defect . - pubmed
Modular organization of human extrastriate visual cortex : evidence from cytochrome oxidase pattern in normal and macular degeneration cases . - pubmed
The pattern of cytochrome oxidase activity in these visual areas is now described in a normal case and in a case of age - related bilateral macular degeneration . - pubmed
PURPOSE : We retrospectively evaluated the ability of human chorionic gonadotropin ( HCG ) to make the nonpalpable cryptorchid testis become palpable and promote testicular descent . - pubmed
NK cells induced both necrosis and apoptosis in cell lines insensitive to NK cells in the presence of an antibody against the major histocompatibility complex class I ( antibody - dependent cell - mediated cytotoxicity , ADCC ) . - pubmed
Hypercellularity , increase in number and morphological alterations of megakaryocytes , raised reticulin content , mild plasmacytosis and frequent presence of reactive lymphoid aggregates are features suggestive , thought not diagnostic , for HIV infection on BMB . - pubmed
Colosplenic fistula in a patient treated with interleukin-2 for malignant melanoma . - pubmed
Interleukin-2 ( IL-2 ) therapy often causes gastrointestinal side effects and at least 8 cases of bowel perforation have been reported . - pubmed
Total lymphocyte and CD4(+)-cell counts for AIDS patients ( 1,451 + /- 811 cells / microliters , P & lt ; 0.001 , and 238 + /- 392 cells / microliters , P & lt ; 0.0001 , respectively and asymptomatic patients ( 2,393 + /- 664 cells / microliters , P & gt ; 0.05 , and 784 + /- 475 cells / microliters , P & lt ; 0.001 , respectively ) were lower than those observed for healthy subjects ( 2,596 + /- 631 cells / microliters and 1,120 + /- 296 cells / microliters , respectively ) . - pubmed
The levels of beta 2 - microglobulin and IgA in serum were significantly elevated in patients with AIDS ( 5.7 + /- 3.6mg / liter , P & lt ; 0.001 , and 541 + /- 265 mg / dl , P & lt ; 0.0002 , respectively ) and asymptomatic infected subjects ( 3.4 + /- 2.1 mg / liter , P = 0.001 , and 436 + /- 216 mg / dl , P & lt ; 0.0001 , respectively ) compared with the levels in healthy subjects ( 2.2 + /- 0.7 mg / liter and 204 + /- 113 mg / dl , respectively ) . - pubmed
Nonstatistically significant differences ( P & gt ; 0.05 ) for concentrations of p24 antigen between asymptomatic infected patients ( 29 + /- 13 pg / ml ) and AIDS patients ( 40 + /- 23 pg / ml ) were observed . - pubmed
Total lymphocyte counts of 1,750 cells / microliters or less , CD4 counts of 200 cells / microliters or less , beta 2 - microglobulin concentrations in serum of 4 mg / liter or higher , concentrations of IgA in serum of 450 mg / dl or higher , and the presence in serum of p24 antigen were correlated with elevated risks for developing AIDS . - pubmed
Monitoring both total lymphocytes and beta 2 - microglobulin identified 91 % of the AIDS patients ; these assays may allow reductions in the annual number of CD4(+)-cell evaluations and the costs associated with monitoring both total lymphocytes and beta 2 - microglobulin identified 91 % of the AIDS patients ; these assays may allow reductions in the annual number of CD4(+)-cell evaluations and the costs associated with monitoring the immune status of HIV - positive patients . - pubmed
In the Born test 4 - chlorophenylethenecarboxamidoxime ( 21 ) was most active and inhibited the blood platelet aggregation induced by collagen with an IC50 = 3 microM. - pubmed
The authors hypothesized that experimental human Wilms ' tumors would display a vascular architecture similar to retinal diseases that are driven by vascular endothelial growth factor ( VEGF ) . - pubmed
CONCLUSIONS : Vascular architecture of Wilms ' tumor displays the specific features previously described in diseases of the retina , which have been shown to be driven by VEGF , suggesting that neoangiogenesis in this model is also VEGF driven . - pubmed
Bilateral simultaneous retinal arteriolar obstruction in a child with hemoglobin SS sickle cell disease . - pubmed
Elevated plasma thrombopoietin levels and thrombosis in essential thrombocythemia : a preliminary report . - pubmed
[ Diffuse large B - cell lymphoma expressing cytoplasmic IgM and kappa in a patient with lambda - type primary macroglobulinemia ] . - pubmed
A biopsy sample was obtained by exploratory laparotomy , and from this a diagnosis of diffuse large cell lymphoma ( DLCL ) expressing cytoplasmic IgM / kappa was made . - pubmed
There was no difference in the plasma monoclonal IgM / lambda level before and during the course of DLCL . - pubmed
First , those identifiable as screen - positive for both Down syndrome and an open neural tube defect ( ONTD ) with elevated MS - AFP , grossly elevated hCG , low / normal uE3 , and probably elevated INH - A. - pubmed
Pregnancies in the second group are identifiable as screen - positive for trisomy 18 with low / normal MS - AFP , and very low hCG , uE3 and INH - A. - pubmed
Triploid pregnancies with high maternal serum hCG nearly always show a placenta with partial mole ( 25/27 or 93 % ) , a high frequency of ONTDs or ventral wall defects ( VWDs ) ( 8/28 or 29 % ) and have either an XXX or XXY karyotype ( observed ratio 6:10 , respectively ) . - pubmed
Low hCG is infrequently associated with a molar placenta ( 1/11 or 9 % ) , does not appear to be associated with ONTDs or VWDs ( 0/29 or 0 % ) , and shows an excess of XXX over XXY karyotypes ( observed ratio 17:2 ) . - pubmed
There were 16 cases with either a molar placenta , an ONTD or a VWD that received the MS - AFP and hCG tests . - pubmed
In addition , all 31 cases that received MS - AFP , hCG , uE3 ( and where available INH - A ) were screen - positive for either Down syndrome or trisomy 18 . - pubmed
P - glycoprotein ( P - gp)/multi - drug resistance 1 ( MDR1 ) gene is recognized to be , at least in part , responsible for the refractoriness to chemotherapy of leukemia . - pubmed
However , recent reports have clarified that early growth response 1 gene ( Egr1 ) positively regulates MDR1 transcription , while Wilms ' tumor suppressor gene ( WT1 ) does negative regulation of MDR1 gene expression in 12 - O - tetradecanoylphorbol-13 - acetate treated K562 cells . - pubmed
Our study of mRNA expression profile of Egr1 , WT1 and MDR1 in fresh AML samples demonstrated that there are disease - specific patterns . - pubmed
mRNA expression of MDR1 was frequent in AML M1 and t(8;21 ) AML cells , in which the expression level was highest in AML M1 and was low in monocytic leukemia ( M4 and M5 ) . - pubmed
By liquid culture of leukemia cell lines and fresh AML cells with the addition of all - trans retinoic acid ( ATRA ) , modulation of P - gp / MDR1 and Egr1 was observed and the pattern of modulation was divided into four groups : ( 1 ) blastic AML type , in which distinct expression of P - gp / MDR1 and CD34 was not influenced by ATRA ; ( 2 ) t(8;21)AML type , in which P - gp / MDR1 expression was augmented by ATRA , while CD34 was kept high ; ( 3 ) AML M3 type , in which P - gp / MDR1 expression was reduced with granulocytic differentiation by ATRA ; ( 4 ) monocytic AML type , in which P - gp / MDR1 expression was augmented by ATRA , while CD34 expression decreased , and strong Egr1 expression was downregulated just prior to the augmentation of P - gp / MDR1 expression . - pubmed
However , P - gp / MDR1 expression augmented by ATRA , which was observed in monocytic AML , was recognized as a functional molecule of mature monocyte / macrophage , because CD34 expression decreased and CD13 expression increased by ATRA . - pubmed
Finally , expression of P - gp / MDR1 in monocytic leukemia , which was functionally confirmed by Rh123 efflux study , was thought to be closely related to the characteristic modulation of Egr1 expression by ATRA . - pubmed
Coincidence of pro- and anti - inflammatory responses in the early phase of severe sepsis : Longitudinal study of mononuclear histocompatibility leukocyte antigen - DR expression , procalcitonin , C - reactive protein , and changes in T - cell subsets in septic and postoperative patients . - pubmed
OBJECTIVE : To determine the time course of histocompatibility leukocyte antigen ( HLA )- DR expression in peripheral blood mononuclear cells and their relationship to markers of inflammation , organ function , and outcome during severe sepsis . - pubmed
MEASUREMENTS AND MAIN RESULTS : Despite a relative lymphopenia , absolute lymphocyte counts and CD4+/CD8 + T - cell ratio in septic patients were significantly elevated above normal . - pubmed
Particularly , CD4 + and CD8 + T - cell counts in nonsurvivors of sepsis were approximately twice as high as those of survivors . - pubmed
Significantly decreased monocytic HLA - DR expression was observed in both survivors and nonsurvivors at the onset of severe sepsis . - pubmed
Percentages of HLA - DR+ lymphocytes , however , were significantly increased during sepsis , especially in nonsurvivors . - pubmed
Whereas survivors of sepsis showed a continuous recovery of monocytic HLA - DR expression to & gt;or=70 % within 10 days , nonsurvivors were characterized by a second decrease in monocytic HLA - DR expression after day 7 or a permanent suppression ( & lt;40 % ) . - pubmed
CONCLUSIONS : Decreases in monocytic HLA - DR expression occurred simultaneously with signs of hyperinflammation as early as the onset of severe sepsis and usually developed in opposite directions than inflammatory markers and sepsis severity scores . - pubmed
TNF and TNF receptor polymorphisms in Korean Behcet ' s disease patients . - pubmed
The serum level of tumor necrosis factor ( TNF ) is elevated in patients with active BD , and its production is elevated in monocytes and in the gamma delta T cells of BD patients . - pubmed
A dramatic response to anti - TNF - alpha antibody treatment further supports the role of TNF in BD . - pubmed
In this study , we investigated genetic polymorphisms of TNF alpha -308 G / A , TNF beta +252 G / A , and TNFR2 196 R / M in 94 Korean BD patients and age- and sex - matched healthy controls to investigate the role of TNF and TNF receptor polymorphisms in BD . - pubmed
In conclusion , this study found no differences of TNF alpha -308 G / A , TNF beta +252 G / A or of the TNFR2 196R / M polymorphisms in Korean BD patients versus healthy controls . - pubmed
These findings suggest that the role of TNF in BD is not genetically determined , but can be functionally explained . - pubmed
Characterization of MTHFR , GSTM1 , GSTT1 , GSTP1 , and CYP1A1 genotypes in childhood acute leukemia . - pubmed
The role of methylenetetrahydrofolate reductase ( MTHFR C677 T ) , glutathione S - transferases ( GSTM1 and GSTT1 null , GSTP1 Ile105Val ) , and cytochromes p450 ( CYP1A1 * 2A ) genotypes in the etiology of childhood leukemia was simultaneously investigated . - pubmed
The frequency of MTHFR genotype was insignificantly higher in ALL ( 7.7 % ) and ANLL ( 6.3 % ) than in controls ( 4.4 % ) . - pubmed
Equal distribution of the GSTM1 null genotype was detected between ALL patients and controls ( 55 % ) , while its incidence was slightly higher in ANLL patients ( 61.3 % ) . - pubmed
Although GSTT1 null genotype was insignificantly lower in ALL patients ( 20.9 % ) than controls ( 22.7 % ) , it was significantly underrepresented in ANLL patients ( 6.5 % ) ( P = 0.05 , OR 0.24 , 95 % CI 0.05 - 1.03 ) . - pubmed
The homozygous frequency of GSTP1 genotype did not differ significantly between groups of ALL ( 3.7 % ) , ANLL patients ( 9.1 % ) and controls ( 4.9 % ) . - pubmed
Homozygous CYP1A1 * 2A genotype was underrepresented in ALL patients ( 1 % ) as compared to control ( 4.8 % ) but the differences did not reach to statistical significance ( OR 0.21 ; 95 % CI 0.03 - 1.72 ) . - pubmed
These results suggested that there are no significant associations between the studied genotypes and the risk of developing either form of acute leukemia except GSTT1 null and homozygosity for CYP1A1 genotypes that may play protective roles in the development of ANLL in Turkish children . - pubmed
Changes in the number of CD80(+ ) , CD86(+ ) , and CD28(+ ) peripheral blood lymphocytes have prognostic value in melanoma patients . - pubmed
Our aim was to evaluate whether the number of circulating lymphocytes expressing costimulatory molecules can be associated with melanoma prognosis . - pubmed
We determined the concentration of peripheral blood lymphocytes , which expressed the CD80 / CD86 or CD28 / CTLA-4 molecules , in 38 patients with cutaneous melanoma and 27 controls . - pubmed
There was a lower number of CD3(+)CD8(+)CD28(+ ) cells , as well as a higher CD3(+)CD8(+)/CD3(+)CD8(+)CD28(+ ) cell ratio , in melanoma patients than in controls . - pubmed
Melanoma patients with thinner tumors and those surviving revealed an increase of CD19(+)CD80(+ ) and CD19(+)CD80(+)CD86(+ ) cells , as well as a higher concentration of CD3(+)CD4(+)CD28(+ ) cells . - pubmed
CD80(+ ) B cells and a low CD8 suppressor / cytolytic cell ratio correlate with a good prognosis in melanoma . - pubmed
Our findings support our conclusion that CD80(+ ) B cells may be important antigen presenting cells that can contribute to an antimelanoma immune response and are candidates to be monitored in melanoma patients . - pubmed
We have shown previously that interferon regulatory factor 7 ( IRF7 ) , a multifunctional protein intimately involved in latent Epstein - Barr virus ( EBV ) infection , is induced as well as activated by EBV latent membrane protein 1 ( LMP1 ) , the principal EBV oncoprotein . - pubmed
[ ACTH and cortisone in the treatment of chronic lymphatic leukemia ] . - pubmed
Effect of phosphodiesterase-5 inhibitor , sildenafil ( Viagra ) , in animal models of airways disease . - pubmed
Phosphodiesterase ( PDE )- 5 degrades guanosine 3 ' , 5'cyclic monophosphate ( cGMP ) and its inhibitor sildenafil citrate ( Viagra ) treats erectile dysfunction by smooth muscle relaxation through elevated cGMP . - pubmed
These antiinflammatory actions of sildenafil in guinea pig models suggest that PDE5 inhibitors may have potential in treating airways disease . - pubmed
18 months later , the cutaneous lesions recurred , angiotensin converting enzyme ( ACE ) serum levels were increased and a chest X - ray demonstrated pulmonary involvement . - pubmed
Nuclear factor - kappa B expression in alveolar macrophages of mechanically ventilated neonates with respiratory distress syndrome . - pubmed
There were close correlations between the expression of NF - kappaB and levels of IL-1beta ( r = 0.78 , p & lt ; 0.01 ) , and IL-8 ( r = 0.81 , p & lt ; 0.01 ) in AA . - pubmed
CONCLUSION : There were alterations in NF - kappaB activity in the AM of mechanically ventilated preterm neonates with RDS , mediated by decreased synthesis and increased degradation of IkappaB. - pubmed
A novel point mutation of the RET protooncogene involving the second intracellular tyrosine kinase domain in a family with medullary thyroid carcinoma . - pubmed
These genetic syndromes are associated with germline - activating mutations of the RET protooncogene , a cell surface tyrosine kinase receptor , which is believed to modulate specific intracellular signaling pathways involved in the regulation of C cell proliferation and apoptosis . - pubmed
Here , we describe a novel missense mutation of the RET protooncogene that substitutes arginine for proline at codon 912 of the intracellular tyrosine kinase domain in a family with medullary thyroid carcinoma . - pubmed
However , this rise does seem to impair the value of PSA in patients with undiagnosed prostate cancer . - pubmed
Aberrant transcription of FHIT gene in intrahepatic cholangiocellular carcinomas induced by N - nitrosobis ( 2 - oxopropyl ) amine in hamsters . - pubmed
Aberrant transcription of the fragile histidine triad ( FHIT ) gene was investigated in intrahepatic cholangiocellular carcinomas ( ICCs ) induced by N - nitrosobis ( 2 - oxopropyl ) amine ( BOP ) in female Syrian golden hamsters . - pubmed
These results suggest that alteration of the FHIT gene may play a role in a small fraction of ICCs induced by BOP in the hamster . - pubmed
In the current study , we further analyzed the signaling pathways involved in PCD mediated by MAb 1D5 . - pubmed
After the third chemotherapy session , metastases had completely disappeared , the serum levels of alpha - fetoprotein and human chorionic gonadotropin beta subunit had normalized and the dermatomyositis symptoms had improved . - pubmed
Several studies suggest that the VEGF receptor pathway and the Tie-2 pathway are independent and essential mediators of angiogenesis , leading to the hypothesis that simultaneous interference with both pathways should result in additive effects in tumor growth . - pubmed
In a human melanoma xenograft mouse model , we could show that blockade of both VEGF - R2 and Tie-2 pathways or the VEGF receptor pathway alone resulted in a significant inhibition of tumor growth and tumor angiogenesis ( 92.2 % and 74.4 % ) . - pubmed
The novel human oncogene hWAPL is associated with uterine cervical cancer . - pubmed
No evidence existed to suggest any association between CYP1A2 and the onset of PD ( P=0.08 ) . - pubmed
OBJECTIVE : To observe whether human papillomavirus 16 ( HPV16 ) E6 - specific small interfering RNAs ( siRNAs ) can be employed to inhibit the growth of cervical cancer cell line , and to investigate the associated mechanism . - pubmed
Acceleration of wound healing in traumatic ulcers by absorbable collagen sponge containing recombinant basic fibroblast growth factor . - pubmed
The objective of this study was to examine the safety and efficacy of topical application of recombinant basic fibroblast growth factor loaded on a kind of absorbable collagen sponge ( rbFGF / ACS ) in patients with chronic traumatic ulcers . - pubmed
Compared with the placebo group , rbFGF / ACS significantly increased the incidence of complete wound closure by 68 % ( 90.0 % versus 53.6 % , P = 0.0019 ) after 3 weeks and shortened the time to achieve complete wound closure by 24 % ( 10.6 days versus 13.9 days , P = 0.0171 ) . - pubmed
rbFGF / ACS significantly increased the incidence of complete wound closure , shortened the complete healing time and improved the healing quality of chronic traumatic ulcers . - pubmed
It was not significantly associated with blood pressure , hypertension , serum total or high density lipoprotein cholesterol , body mass , diabetes , gout , osteoporosis , cardiovascular disease , smoking , caffeine use , or taking calcium channel blockers or anticholesterol medications . - pubmed
Predictable removal of anticardiolipin antibody by therapeutic plasma exchange ( TPE ) in catastrophic antiphospholipid antibody syndrome ( CAPS ) . - pubmed
We report predictive and effective removal of pathological anticardiolipin antibody ( aCL AB ) in a patient with CAPS . - pubmed
Circulating dickkopf-1 and radiological progression in patients with early rheumatoid arthritis treated with etanercept . - pubmed
OBJECTIVE : Dickkopf-1 ( Dkk-1 ) regulates bone remodeling in animal models of inflammatory arthritis , but its role in patients with rheumatoid arthritis ( RA ) remains unclear . - pubmed
METHODS : Baseline circulating Dkk-1 was measured in 113 patients with RA ( & lt ; 3 yrs ) who received etanercept ( 10 or 25 mg twice / week , n = 63 ) or methotrexate alone ( n = 40 ) for 1 year . - pubmed
RESULTS : Increased Dkk-1 was associated with a higher risk of progression of bone erosion , independently of age , sex , baseline radiological damage , C - reactive protein , and disease activity in patients treated with etanercept . - pubmed
CONCLUSION : Dkk-1 may be an important mediator of bone erosion in patients with RA . - pubmed
FGFR1 that is normally associated with activated nonparenchymal cells appears ectopically in hepatoma cells . - pubmed
Ectopic expression and chronic activity of FGFR1 in hepatocytes accelerates diethylnitrosamine ( DEN)-initiated hepatocarcinogenesis by driving unrestrained cell proliferation and tumor angiogenesis . - pubmed
Here we ask whether FGFR4 plays a role in progression of hepatocellular carcinoma ( HCC ) . - pubmed
We report that although spontaneous HCC was not detected in livers of FGFR4 - deficient mice , the ablation of FGFR4 accelerated DEN - induced hepatocarcinogenesis . - pubmed
In contrast to FGFR1 that induced a strong mitogenic response and depressed rate of cell death in hepatoma cells , FGFR4 failed to induce a mitogenic response and increased the rate of cell death . - pubmed
These results suggest that in contrast to ectopic FGFR1 that is a strong promoter of hepatoma , resident FGFR4 that mediates differentiated hepatocyte metabolic functions also serves to suppress hepatoma progression . - pubmed
BACKGROUND : A recent meta - analysis study showed that post - operative adjuvant chemotherapy with UFT , an oral combination drug composed of tegafur [ prodrug of 5 - fluorouracil ( 5 - FU ) ] and uracil [ inhibitor of dihydropyrimidine dehydrogenase ( DPD ) ] was associated with improved survival in patients with lung adenocarcinomas , but not in those with lung squamous cell carcinomas . - pubmed
METHODS : We investigated the 5 - FU - related gene expression levels of thymidylate synthase ( TS ) , DPD , thymidine phosphorylase ( TP ) and orotate phosphoribosyl transferase ( OPRT ) in resected tumor specimens from 51 patients with adenocarcinomas and 47 with squamous cell carcinomas using quantitative reverse transcription - PCR , and compared those levels between the two histological types . - pubmed
RESULTS : The relative gene expression values of TS , TP and OPRT were significantly lower in adenocarcinomas compared with squamous cell carcinomas , 1.60 + /- 0.86 versus 4.33 + /- 3.40 ( P & lt ; 0.001 ) , 0.84 + /- 0.52 versus 2.27 + /- 1.16 ( P = 0.006 ) and 9.59 + /- 6.30 versus 16.94 + /- 12.04 ( P & lt ; 0.001 ) , respectively . - pubmed
The relative gene expression value of DPD was significantly greater in adenocarcinomas than those in squamous cell carcinomas , 2.33 + /- 1.22 versus 1.50 + /- 1.20 ( P = 0.01 ) . - pubmed
Lower expressions of TS and TP were observed more in adenocarcinomas ( 89.8 % ) than in squamous cell carcinomas ( 48.9 % ) ( P & lt ; 0.001 ) . - pubmed
Effector ( Teff ) and regulatory ( Treg ) T cells produce cytokines that balance immunity and immunopathology at sites of infection . - pubmed
Potential relevance of cerebrospinal fluid and serum levels and intrathecal synthesis of active matrix metalloproteinase-2 ( MMP-2 ) as markers of disease remission in patients with multiple sclerosis . - pubmed
BACKGROUND : Little is known about the involvement of matrix metalloproteinase-2 ( MMP-2 ) and its tissue inhibitor TIMP-2 in multiple sclerosis ( MS ) . - pubmed
OBJECTIVE : To elucidate the actual implication of MMP-2 and TIMP-2 in MS . - pubmed
METHODS : Cerebrospinal fluid ( CSF ) and serum levels of active MMP-2 and TIMP-2 were measured by activity assay system and ELISA , respectively , in 67 patients with relapsing - remitting MS ( RRMS ) , categorized according clinical and magnetic resonance imaging ( MRI ) , and in 129 controls . - pubmed
RESULTS : Cerebrospinal fluid and serum active MMP-2 / TIMP-2 ratio mean values and an intrathecal active MMP-2 production were more increased in RRMS than in non - inflammatory conditions ( P & lt ; 0.001 , P & lt ; 0.05 , and P & lt ; 0.0001 , respectively ) and in MRI inactive than in MRI active RRMS ( P & lt ; 0.02 , P & lt ; 0.01 and P & lt ; 0.001 , respectively ) . - pubmed
An intrathecal synthesis of active MMP-2 was more frequent in RRMS than in inflammatory disorders ( P & lt ; 0.01 ) . - pubmed
CONCLUSION : These findings suggest a potential role for MMP-2 activity in the termination of MS neuroinflammation related to remission of the disease and seem to indicate that serum MMP-2 / TIMP-2 ratio may represent a useful biomarker for monitoring MS recovery phase . - pubmed
Antibodies targeting hepatoma - derived growth factor as a novel strategy in treating lung cancer . - pubmed
Hepatoma - derived growth factor ( HDGF ) is overexpressed in lung cancer and the overexpression correlates with aggressive biological behaviors and poor clinical outcomes . - pubmed
We developed anti - HDGF monoclonal antibodies and tested their antitumor activity in lung cancer xenograft models . - pubmed
We also determined biological effects in tumors treated with the antibody alone or in combination with bevacizumab / avastin ( an anti - vascular endothelial growth factor antibody ) and/or gemcitabine ( a chemotherapeutic agent ) . - pubmed
We found the anti - HDGF was effective to inhibit tumor growth in non - small cell lung cancer xenograft models . - pubmed
In the A549 model , compared with control IgG , tumor growth was substantially inhibited in animals treated with anti - HDGF antibodies , particularly HDGF - C1 ( P = 0.002 ) and HDGF - H3 ( P = 0.005 ) . - pubmed
When HDGF - H3 was combined with either bevacizumab or gemcitabine , we observed enhanced tumor growth inhibition , particularly when the three agents were used together . - pubmed
HDGF - H3 - treated tumors exhibited significant reduction of microvessel density with a pattern distinctive from the microvessel reduction pattern observed in bevacizumab - treated tumors . - pubmed
HDGF - H3 - treated but not bevacizumab - treated tumors also showed a significant increase of apoptosis . - pubmed
Interestingly , many of the apoptotic cells in HDGF - H3 - treated tumors are stroma cells , suggesting that the mechanism of the antitumor activity is , at least in part , through disrupting formation of tumor - stroma structures . - pubmed
Our results show that HDGF is a novel therapeutic target for lung cancer and can be effectively targeted by an antibody - based approach . - pubmed
Brain natriuretic peptide in chronic thromboembolic pulmonary hypertension . - pubmed
Rashes and visceral involvement have started to be reported more often , especially with tumor necrosis factor antagonists . - pubmed
OUTCOMES : Protein - caloric malnutrition ( defined as the occurrence of 1 of the following : loss of body weight & gt ; 5 % in 1 month or 7.5 % in 3 months or body mass index & lt ; 20 kg / m(2 ) with serum albumin level & lt ; 3.2 g / dL and normal C - reactive protein level [ & lt;0.5 mg / dL ] ) , dialysis , death , or the composite outcome of dialysis and death . - pubmed
The induction of vessel - like networks is dependent from proper glycosylation of collagens and does not occur on osteogenic ECMs if deglycosylated by -galactosidase or on less glycosylated ECMs derived from preosteoblasts and normal fibroblasts , while is sustained on ECM from osteogenesis imperfecta fibroblasts only when their mutation is associated with over - glycosylation of collagen type I. - pubmed
Update on lipids and C - reactive protein in acute and chronic coronary heart disease . - pubmed
Do calcium channel blockers increase the diagnosis of heart failure in patients with hypertension ? - pubmed
In conclusion , suppression of HAS2 activity may represent an early process of GC - induced skin atrophy that precedes the suppression of collagens . - pubmed
Genome - wide association studies have underscored the importance of the clustered neuronal nicotinic acetylcholine receptor ( nAChR ) subunit genes with respect to nicotine dependence as well as lung cancer susceptibility . - pubmed
Immunohistochemical staining was positive for S-100 protein and glial fibrillary acidic protein ( GFAP ) , and negative for Melan - A. Interestingly , there was no histological evidence of glaucoma . - pubmed
Female Beagle dogs ( 9 - 10 mo old ; 8.2 + - 0.2 kg body weight ) were fed 0 , 10 , 20 or 40 mg astaxanthin daily and blood sampled on wk 0 , 6 , 12 , and 16 for assessing the following : lymphoproliferation , leukocyte subpopulations , natural killer ( NK ) cell cytotoxicity , and concentrations of blood astaxanthin , IgG , IgM and acute phase proteins . - pubmed
Here , we examine the role of beta - arrestin1 and beta - arrestin2 in the pathobiology of pulmonary fibrosis . - pubmed
In the bleomycin - induced mouse lung fibrosis model , loss of either beta - arrestin1 or beta - arrestin2 resulted in protection from mortality , inhibition of matrix deposition , and protected lung function . - pubmed
Furthermore , knockdown of beta - arrestin2 in fibroblasts from patients with idiopathic pulmonary fibrosis attenuated the invasive phenotype . - pubmed
These data implicate beta - arrestins as mediators of fibroblast invasion and the development of pulmonary fibrosis , and as a potential target for therapeutic intervention in patients with idiopathic pulmonary fibrosis . - pubmed
Response to the high - dose corticotrophin stimulation test depends on plasma adrenocotropin hormone levels in septic shock . - pubmed
PURPOSE : The use of the high - dose corticotrophin stimulation test ( HDCST ) as a guide to use low - dose steroid therapy in septic shock is controversial . - pubmed
We evaluated the correlation of the response to the HDCST with plasma ACTH levels in patients with septic shock . - pubmed
METHODS : This is a retrospective review of 102 patients with septic shock in which adrenal function was evaluated using the HDCST and plasma ACTH levels were measured . - pubmed
CONCLUSION : Patients with septic shock with higher plasma ACTH values presented a subnormal response to the HDCST . - pubmed
In response to an outbreak of Crimean - Congo hemorrhagic fever in western Afghanistan , we measured immunoglobulin G seroprevalence among household members and their animals . - pubmed
The expression patterns and correlations of claudin-6 , methy - CpG binding protein 2 , DNA methyltransferase 1 , histone deacetylase 1 , acetyl - histone H3 and acetyl - histone H4 and their clinicopathological significance in breast invasive ductal carcinomas . - pubmed
BACKGROUND : Claudin-6 is a candidate tumor suppressor gene in breast cancer , and has been shown to be regulated by DNA methylation and histone modification in breast cancer lines . - pubmed
However , the expression of claudin-6 in breast invasive ductal carcinomas and correlation with clinical behavior or expression of other markers is unclear . - pubmed
METHODS : We have investigated the expression of claudin-6 , MeCP2 , HDAC1 , H3Ac and H4Ac in 100 breast invasive ductal carcinoma tissues and 22 mammary gland fibroadenoma tissues using immunohistochemistry . - pubmed
RESULTS : Claudin-6 protein expression was reduced in breast invasive ductal carcinomas ( P & lt ; 0.001 ) . - pubmed
H3Ac expression was associated with tumor size ( P = 0.044 ) and clinical stage of cancers ( P = 0.034 ) . - pubmed
CONCLUSIONS : Our results show that claudin-6 protein is significantly down - regulated in breast invasive ductal carcinomas and is an important correlate with lymphatic metastasis , but claudin-6 down - regulation was not correlated with upregulation of the methylation associated proteins ( MeCP2 , DNMT1 ) or histone modification associated proteins ( HDAC1 , H3Ac , H4Ac ) . - pubmed
Interestingly , the expression of MeCP2 was positively correlated with the expression of H3Ac and H3Ac protein expression was positively correlated with the expression of H4Ac in breast invasive ductal carcinoma VIRTUAL SLIDES : The virtual slide(s ) for this article can be found here : http://www.diagnosticpathology.diagnomx.eu/vs/4549669866581452 . - pubmed
An overview of cutaneous vasculature , role of alpha - adrenoreceptors , and a discussion of available medical therapies and treatment selection are also presented , including emerging topical options for diffuse and persistent facial erythema of rosacea . - pubmed
Vildagliptin selectively ameliorates GLP-1 , GLUT4 , SREBP-1c mRNA levels and stimulates beta - cell proliferation resulting in improved glucose homeostasis in rats with streptozotocin - induced diabetes . - pubmed
OBJECTIVE : Inhibitors of dipeptidyl peptidase-4 ( DPP-4 ) , a key regulator of the actions of incretin hormones , exert antihyperglycemic effects in type 2 diabetic patients . - pubmed
A major unanswered question concerns the potential ability of DPP-4 inhibition to have beneficial disease - modifying effects , specifically to attenuate loss of pancreatic beta - cell mass and function due to oxidative stress induced inflammation . - pubmed
Here , we investigated the effects of a potent and selective DPP-4 inhibitor vildagliptin on glycemic control , pancreatic beta - cell mass and function , genes and proteins expressions , tumor necrosis factor - alpha , and nitric oxide in an n2 - STZ diabetic model of rat with defects in insulin sensitivity and secretion . - pubmed
CONCLUSION : These findings suggest that DPP-4 inhibitors may offer long - lasting efficacy in the treatment of diabetes mellitus by modifying the courses of the disease . - pubmed
HIF-2alpha is stabilized in von Hippel - Lindau ( VHL )- deficient renal cell carcinoma through mechanisms that require ongoing mRNA translation . - pubmed
Rictor - associated mTORC2 complex has been linked to maintaining HIF-2alpha protein in the absence of VHL ; however , the mechanisms remain to be elucidated . - pubmed
Furthermore , we provide the first evidence that silencing of p22 ( phox ) reduces HIF-2alpha - dependent gene targeting in vitro and tumor formation in vivo . - pubmed
Glycemic Control among Pregnant Diabetic Women on Insulin Who Fasted During Ramadan . - pubmed
The objective of this study was to determine the glycemic control in pregnant diabetic women on insulin who fasted during Ramadan . - pubmed
RESULTS : Thirty seven women opted to fast with 24 ( 64.9 % ) of them had type 2 diabetes mellitus and 83.8 % of them required combined insulin ( short- acting , intermediate - acting ) therapy . - pubmed
CONCLUSION : the findings indicate that pregnant diabetic women on insulin were able to fast during Ramadan and that their glycemic control was improved during fasting period . - pubmed
Clinical use of p - proteasome in discriminating metastatic melanoma patients : comparative study with LDH , MIA and S100B protein . - pubmed
The objective of this study was to compare the diagnostic and prognostic values of p - proteasome with three other melanoma serological markers : S100B protein , melanoma inhibitory activity protein ( MIA ) and lactate dehydrogenase ( LDH ) in the plasma of 121 stage I - IV melanoma patients . - pubmed
P - proteasome and S100B were the most sensitive ( 58.1 % ) and p - proteasome and MIA the most specific ( 98.7 and 100 % ) in detecting metastatic disease . - pubmed
The syndrome of apparent mineralocorticoid excess ( AME ) is an autosomal recessive disorder characterized by hypertension , hypokalemia , low renin , and hypoaldosteronism . - pubmed
We report three siblings - two female and one male - with the syndrome of apparent mineralocorticoid excess who presented with hypertension , hypokalemia , low renin , and low aldosterone levels . - pubmed
The addition of spironolactone resulted in a decrease in blood pressure , rise in serum potassium and a gradual increase in plasma renin activity in all three . - pubmed
In this study , the genetic testing of those three siblings with the typical clinical features of AME has detected missense mutation c.662C>T ( p. Arg208Cys ) in exon 3 of the HSD11B2 gene in the homozygous state . - pubmed
Urinary steroid profile and molecular analysis confirmed the diagnosis of non - classic congenital adrenal hyperplasia ( NCCAH ) due to 21 - hydroxylase deficiency . - pubmed
Previous systematic reviews found higher prevalences of anti - EBV antibodies in MS patients compared to controls , but many studies have since been published , and there is a need to apply more rigorous systematic review methods . - pubmed
METHODOLOGY / PRINCIPAL FINDINGS : We examined the link between EBV and MS by conducting a systematic review and meta - analysis of case - control and cohort studies that examined the prevalence of anti - EBV antibodies in the serum of cases and controls . - pubmed
The meta - analysis showed a significant OR for sero - positivity to anti - EBNA IgG and anti - VCA IgG in MS cases ( 4.5 [ 95 % confidence interval ( CI ) 3.3 to 6.6 , p<0.00001 ] and 4.5 [ 95 % CI 2.8 to 7.2 , p<0.00001 ] respectively ) . - pubmed
Soluble isoform of the receptor for advanced glycation end products as a biomarker for postoperative respiratory failure after cardiac surgery . - pubmed
We measured the serum levels of the soluble isoform of the receptor for advanced glycation end products ( sRAGE ) , and we studied its association with postoperative respiratory failure . - pubmed
Receiver operating characteristic curve analysis demonstrated that postoperative sRAGE had a predictive performance with area under the curve of 0.81 ( 95 % confidence interval 0.71 - 0.88 ) for postoperative respiratory failure , defined as prolonged mechanical ventilation & gt;3 days . - pubmed
CONCLUSIONS : Serum sRAGE levels elevated immediately after cardiac surgery , and the range of elevation was associated with the morbidity of postoperative respiratory failure . - pubmed
Early postoperative sRAGE levels appear to be linked to cardiopulmonary bypass , and may have predictive performance for postoperative respiratory failure ; however , large - scale validation studies are needed . - pubmed
As neurodegenerative diseases are associated with inflammation we determined if clenbuterol could suppress NFkappaB activation that occurs in response to an inflammatory stimulus . - pubmed
Norovirus triggered microbiota - driven mucosal inflammation in interleukin 10 - deficient mice . - pubmed
In this study , the influence of murine norovirus ( MNV ) infection on clinical , histopathological , and immunological features of mucosal inflammation in the IL10 - deficient ( Il10 ) mouse model of inflammatory bowel disease was examined . - pubmed
METHODS : C57BL/6J and C3H / HeJBir wild - type and Il10 mice kept under special pathogen - free conditions and devoid of clinical and histopathological signs of mucosal inflammation were monitored after MNV infection for structural and functional intestinal barrier changes by in situ MNV reverse transcription PCR , transgene reporter gene technology , histology , flux measurements , quantitative real - time PCR , immunohistology , and terminal deoxynucleotidyl transferase - mediated dUTP nick end - labeling assay . - pubmed
RESULTS : Although MNV - infected wild - type mice remained asymptomatic , mucosal inflammation was noted in previously healthy Il10 mice 2 to 4 weeks after infection . - pubmed
BACKGROUND : Plerixafor is a Food and Drug Administration - approved agent for improving peripheral blood stem cell ( PBSC ) mobilization in filgrastim ( granulocyte - colony - stimulating factor [ G - CSF])-stimulated patients with multiple myeloma and non - Hodgkin ' s lymphoma . - pubmed
STUDY DESIGN AND METHODS : We retrospectively reviewed the collection data of 27 consecutive HL patients at our center in whom plerixafor was added to rescue a failing PBSC collection after G - CSF and chemotherapy ( 26 ) or G - CSF alone ( 1 ) . - pubmed
A phase II study of erlotinib monotherapy in pre - treated non - small cell lung cancer without EGFR gene mutation who have never / light smoking history : re - evaluation of EGFR gene status ( NEJ006 / TCOG0903 ) . - pubmed
OBJECTIVES : Epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitors are particularly effective in non - small cell lung cancer ( NSCLC ) patients harboring active EGFR mutations . - pubmed
However , some studies have reported survival benefits in NSCLC patients with wild - type EGFR upon erlotinib treatment . - pubmed
PATIENTS AND METHODS : Patients with previously treated NSCLC but without EGFR gene mutations that had never or light smoked were eligible for this study . - pubmed
Re - evaluations for EGFR gene were performed in 32 tumor samples . - pubmed
Six patients had PR and two had SD among these eight patients . - pubmed
Patients with tumors expressing HGF showed shorter PFS but not MET or TS . - pubmed
In confirmed EGFR wild NSCLC , negative HGF staining could be a biomarker for longer PFS by erlotonib treatment . - pubmed
Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4 . - pubmed
We investigated the effects of sitagliptin ( SITA ) , an inhibitor of dipeptidylpeptidase-4 ( DPP-4 ) and anti - diabetic drug , on LV structure and function of obese mice with Type 2 DM . - pubmed
METHODS AND RESULTS : Obese Type 2 diabetic mice ( Lepr(db / db ) , BKS.Cg - Dock7(m)+/+ Lepr(db)/J ) , displaying increased cardiomyocyte and LV stiffness at the age of 16 weeks , were treated with SITA ( 300 mg / kg / day ) or vehicle for 8 weeks . - pubmed
CONCLUSIONS : In obese Type 2 diabetic mice , in the absence of hypoglycaemic effects , inhibition of DPP-4 decreases LV passive stiffness and improves global LV performance . - pubmed
OBSERVATIONS : Whole - exome sequencing identified a novel , heterozygous p.(Gly671Trp ) mutation in the AFG3L2 gene encoding an mt protease -- previously associated with dominant spinocerebellar ataxia type 28 disease -- in a patient with indolent ataxia and PEO . - pubmed
Targeted analysis of a larger , genetically undetermined cohort of patients with PEO with suspected mtDNA maintenance abnormalities identified a second unrelated patient with a similar phenotype and a novel , heterozygous p.(Tyr689His ) AFG3L2 mutation . - pubmed
CONCLUSIONS AND RELEVANCE : Our observations suggest that AFG3L2 mutations are another important cause , albeit rare , of a late - onset ataxic PEO phenotype due to a disturbance of mtDNA maintenance . - pubmed
Abnormal nuclear expression of Pygopus-2 in human primary hepatocellular carcinoma correlates with a poor prognosis . - pubmed
The aim of the present study was to investigate the expression patterns and clinicopathological significance of Pygo2 in human primary hepatocellular carcinoma ( HCC ) . - pubmed
METHODS AND RESULTS : Real - time polymerase chain reaction ( PCR ) analysis of the mRNA levels of Pygo2 in 50 paired HCC cancer / adjacent non - cancerous tissues showed that Pygo2 mRNA expression was significantly higher in cancerous tissues ( P = 0.009 ) . - pubmed
Immunohistochemical analysis showed that abnormal Pygo2 protein expression in HCC patients was associated with age ( P = 0.025 ) , tumour size ( P = 0.005 ) , intra- or extra - hepatic metastasis ( P = 0.029 ) , vascular invasion ( P = 0.026 ) and tumour differentiation ( P = 0.004 ) . - pubmed
Cox 's proportional hazard regression model showed that abnormal Pygo2 protein expression was a risk factor associated with the prognosis of HCC patients ( P = 0.043 ) . - pubmed
CONCLUSION : To the best of our knowledge , this is the first report investigating Pygo2 expression patterns and their clinicopathological significance in HCC . - pubmed
Our findings suggest that Pygo2 may be an important predictor of poor outcome in HCC patients , and could serve as a novel biomarker for HCC . - pubmed
In addition , logistic binary regression analysis and linear regression analysis showed the miR-22 - 3p to be a protective factor for POF ( odds ratio 0.766 , 95 % CI 0.643 - 0.912 ) and negatively associated with serum FSH . - pubmed
Plasma IL-1Ra : linking hyperapoB to risk factors for type 2 diabetes independent of obesity in humans . - pubmed
BACKGROUND / OBJECTIVE : Plasma apoB predicts the incidence of type 2 diabetes ( T2D ) ; however , the link between apoB - linpoproteins and risks for T2D remain unclear . - pubmed
Insulin resistance ( IR ) and compensatory hyperinsulinemia characterize prediabetes , and the involvement of an activated interleukin-1 ( IL-1 ) family , mainly IL-1beta and its receptor antagonist ( IL - Ra ) , is well documented . - pubmed
We hypothesized that obese subjects with hyperapoB have an activated IL-1 system that explains hyperinsulinemia and IR in these subjects . - pubmed
Plasma apoB ( 0.34 - 1.80 g l(-1 ) ) associated significantly with hypersinsulinemia ( totalIVGTT : C - peptide r=0.27 , insulin r=0.22 ) , IR ( M / I=-0.29 ) and plasma IL-1Ra ( r=0.26 ) but not with IL-1beta . - pubmed
Plasma IL-1Ra associated with plasma IL-1beta ( r=0.40 ) , and more strongly with hyperinsulinemia and IR than apoB , while the association of plasma IL-1beta was limited to second phase and total insulin secretion ( r=0.23 ) . - pubmed
Adjusting the association of plasma apoB to hyperinsulinemia and IR for IL-1Ra eliminated these associations . - pubmed
CONCLUSION : Plasma apoB is associated with hyperinsulinemia and IR in normoglycemic obese subjects , which is eliminated upon adjustment for plasma IL-1Ra . - pubmed
This may implicate the IL-1 family in elevated risks for T2D in obese subjects with hyperapoB. - pubmed
Evaluation of Abbott Architect high - sensitivity troponin I assay for haemolysis interference . - pubmed
RESULTS : PCR results indicated that 90.6 % ( 48/53 ) , 82 % ( 50/61 ) and 73.6 % ( 39/53 ) strains from DU patients were positive for cagA , vacA , and babA2 , respectively . - pubmed
After the final behavioral testing , L3 - L5 spinal cord tissues were removed to exam the expression of microglia marker OX42 by Western blotting and immunofluorescence technique , and the changes in the expression of inflammation factor IL-1beta , IL-6 , TNF - alpha were detected by ELISA technique . - pubmed
The ratio of spinal microglia marker OX42 and GAPDH , the expression of inflammation factor IL-1beta , IL-6 , and TNF - alpha in group N were 0.074 + -0.023 , ( 35.93 + -6.16 ) pg / ml , ( 92.11 + -13.23 ) pg / ml , and ( 169.50 + -22.64 ) pg / ml , respectively . - pubmed
The ratio of spinal microglia marker OX42 and GAPDH , the expression of inflammation factor IL-1beta , IL-6 , and TNF - alpha in group DNP were 1.023 + -0.185 , ( 73.82 + -9.25 ) pg / ml , ( 155.33 + -21.82 ) pg / ml , and ( 298.30 + -33.21 ) pg / ml , respectively . - pubmed
The ratio of spinal microglia marker OX42 and GAPDH , the expression of inflammation factor IL-1beta , IL-6 , and TNF - alpha in group Sham were 0.951 + -0.103 , ( 73.00 + -7.54 ) pg / ml , ( 151.02 + -24.26 ) pg / ml , and ( 294.01 + -36.37 ) pg / ml , respectively . - pubmed
Compared with group N , the expression of spinal microglia marker OX42 and inflammation factor IL-1beta , IL-6 , and TNF - alpha in group DNP , group Sham and group R increased significantly ( F=7.501 , 348.698 , 568.021 , 145.110 , all P<0.05 ) . - pubmed
Compared with DNP group , the expression of spinal microglia marker OX42 and inflammation factor IL-1beta , IL-6 , and TNF - alpha of group R reduced significantly ( all P<0.05 ) . - pubmed
Therefore , this review focuses on the role that the interaction between vitamin D , VDR function , and gut microbiome might have on autoimmune diseases in the context of the hygiene hypothesis . - pubmed
The biologically active form of vitamin D , 1,25 ( OH ) 2D3 , serves as the primary ligand for VDRs , which have been shown to play a fundamental role in reducing autoimmune disease symptoms . - pubmed
Although the biological functions of VDR , the effects of its genetic variants , and the effects of epigenetic profiles in its promoter region are largely unknown in humans , studies in murine models are increasingly demonstrating that VDRs play a crucial role in attenuating autoimmune disease symptoms by regulating autophagy and the production of antimicrobial peptides , such cathelicidin and beta - defensin , which are responsible for modifying the intestinal microbiota to a healthier composition . - pubmed
Therefore , understanding the interaction between VDR and gut microbiota is of the utmost importance toward understanding the rise in autoimmune diseases in Western countries . - pubmed
We have gained insights on how the VDR functions affects inflammation , autophagy , and microbiota composition that could lead to the development of pathogenesis of autoimmune diseases , while confirming the role vitamin D and VDRs have in the context of hygiene hypothesis . - pubmed
Polymorphisms and features of cytomegalovirus UL144 and UL146 in congenitally infected neonates with hepatic involvement . - pubmed
In this study , we investigated the polymorphisms and features of the viral genes UL144 and UL146 as well as their significance to congenital hepatic involvement . - pubmed
In 79 neonates with congenital cytomegalovirus infection and hepatic involvement , full length UL144 and UL146 were successfully amplified in 73.42 % and 60.76 % of cases , respectively . - pubmed
In conclusion , dominant UL144 ( genotype B ) and UL146 ( genotype G1 and G13 ) genotypes are associated with elevated levels of enzymes and CMV IgM and IgG of cytomegalovirus infection . - pubmed
A mutation ( p. A211V ) in the gene that encodes VGLUT3 is responsible for progressive deafness in two unrelated families . - pubmed
A point mutation of VGLUT3 ( VGLUT3 - p. A211V ) responsible for a progressive loss of hearing has been identified in humans . - pubmed
Expression of P301L - hTau in mouse MEC induces hippocampus - dependent memory deficit . - pubmed
Intracellular accumulation of abnormally phosphorylated tau in different types of neurons is a pathological characteristic of Alzheimer ' s disease ( AD ) . - pubmed
While tau modification and associated neuronal loss and hypometabolism start in the entorhinal cortex ( EC ) in early AD patients , the mechanism by which mutant P301L hTau leads to dementia is not fully elucidated . - pubmed
Here , we studied the effects of P301L hTau transduction in the medial EC ( MEC ) of mice on tau phosphorylation and accumulation , and cognitive deficit . - pubmed
Interestingly , expression of the mutant tau in MEC induces endogenous tau hyperphosphorylation and accumulation in hippocampus and cortex , and inhibits neuronal activity with attenuated PP - DG synapse plasticity , leading to hippocampus - dependent memory deficit with intact olfactory function . - pubmed
These findings suggest a novel neuropathological mechanism of early AD , which is initiated by tau accumulation in MEC , and demonstrate a tau pathological model of early stage AD . - pubmed
Fluctuation of diffusion - weighted imaging and apparent diffusion coefficient in acute stroke following tissue plasminogen activator administration . - pubmed
Role of triosephosphate isomerase and downstream functional genes on gastric cancer . - pubmed
Triosephosphate isomerase ( TPI ) is highly expressed in many types of human tumors and is involved in migration and invasion of cancer cells . - pubmed
However , TPI clinicopathological significance and malignant function in gastric cancer ( GC ) have not been well defined . - pubmed
The present study aimed to examine TPI expression in GC tissue and its biological functions . - pubmed
Our results showed that TPI expression was higher in gastric cancer tissues than adjacent tissues , although no statistical differences were found between TPI expression and clinicopathological factors . - pubmed
TPI overexpression in human gastric carcinoma cell line BGC-823 enhanced cell proliferation , invasion and migration , but did not change cell cycle distribution , while TPI knockdown suppressed proliferation , invasion and migration , induced apoptosis and increased G2 / M arrest of human gastric carcinoma cell line MGC-803 . - pubmed
These results indicated that TPI expression level might affect GC cell behavior , suggesting that both TPI and CDCA5 might be considered as potential tumor markers related with GC development and might be potential new targets in GC treatment . - pubmed
Objectives The association of anti - tumor necrosis factor therapy with opportunistic infections in rheumatoid arthritis ( RA ) patients has been reported . - pubmed
PURPOSE : The upregulation of vascular cell adhesion molecule-1(VCAM-1 ) on vascular endothelium plays a great role in the progression of atherosclerosis ( AS ) . - pubmed
In this study , ultrasound molecular imaging was performed to monitor the inflammation injuries in the onset and progression of atherosclerosis with microbubbles targeted to VCAM-1 . - pubmed
METHODS : Mice deficient for the apolipoprotein E ( ApoE-/-mice ) with high - cholesterol diet were studied as an age - dependent model of atherosclerosis . - pubmed
Moreover , signals from targeted microbubbles increased from 8wks to 32wks age ( P<0.05 for trend ) in ApoE-/- mice , indicating the upregulation of VCAM-1 with the progression of atherosclerosis . - pubmed
CONCLUSIONS : CEU molecular imaging can be used to noninvasively detect the VCAM-1 expression on the endothelium in the progression of atherosclerosis . - pubmed
Single - molecule DNA sequencing of acute myeloid leukemia and myelodysplastic syndromes with multiple TP53 alterations . - pubmed
Prostate cancer ( PCa ) is a leading cause of cancer - related deaths in men and the TMPRSS2 - ERG gene fusion is a recurrent biomarker in about 50 % of all prostate cancers . - pubmed
However , current screening tools for TMPRSS2 - ERG are generally confined to research settings and hence , the development of a rapid , sensitive and accurate assay for TMPRSS2 - ERG detection may aid in clinical PCa diagnosis and treatment . - pubmed
Our assay can specifically detect as low as 103 copies input of TMPRSS2 - ERG transcripts and was successfully applied to clinical PCa urinary samples . - pubmed
Hence , we believe our assay is a potential clinical screening tool for TMPRSS2 - ERG in PCa and may have broad applications in detecting other gene fusion transcripts in other diseases . - pubmed
We evaluated the changes in endometriosis - associated pain scores ( visual analog scale [ VAS ] ) , serum cancer antigen 125 ( CA-125 ) levels , and endometrioma sizes following DNG medication in these women along with adverse events associated with DNG medication . - pubmed
Moreover , the size of recurrent endometriomas and CA-125 levels also decreased significantly compared to baseline . - pubmed
Here , we aim to study whether leukocyte telomere length ( LTL ) may independently predict albuminuria progression in patients with T2D with preserved renal filtration function ( estimated GFR & gt;60 ml / min per 1.73 m2 and urine albumin - to - creatinine ratio [ uACR ] & lt;300 mg / g ) . - pubmed
Several lymphoma treatments have reported anti - pruritic effects including romidepsin , a potent class 1 selective histone deacetylase inhibitor approved for the treatment of patients with CTCL who have had at least one prior systemic therapy . - pubmed
R406 elicits anti - Warburg effect via Syk - dependent and -independent mechanisms to trigger apoptosis in glioma stem cells . - pubmed
Utilizing an anti - cancer compound library , we identified R406 , the active metabolite of a FDA - approved Syk inhibitor for immune thrombocytopenia ( ITP ) , with remarkable cytotoxicity against GSCs but not normal neural stem cells . - pubmed
Co - localizations of fRPE e / sQTLs with age - related macular degeneration ( AMD ) and myopia GWAS data suggest new candidate genes , and mechanisms by which a common RDH5 allele contributes to both increased AMD risk and decreased myopia risk . - pubmed
Previous studies have regarded the discriminatory serum beta - hCG zone ( DSZ ) as a valuable tool for the diagnosis of ectopic pregnancy ( EP ) . - pubmed
We enrolled participants with IUPs or EPs with abdominal pain and/or vaginal bleeding , and serum beta - hCG level measurements and transvaginal ultrasound ( TVS ) were performed to assess the diagnostic value of the indicators for EP . - pubmed
Association of TILs with clinical parameters , Recurrence Score results , and prognosis in patients with early HER2 - negative breast cancer ( BC)-a translational analysis of the prospective WSG PlanB trial . - pubmed
METHODS : The WSG PlanB trial compared an anthracycline - free chemotherapy regimen ( 6x docetaxel / cyclophosphamide , TC ) to an anthracycline - taxane sequence ( 4xEC followed by 4x docetaxel ) in patients with intermediate - risk , HER2 - negative early breast cancer ( EBC ) . - pubmed
CONCLUSION : Although the presence of high TILs is associated with negative prognostic parameters such as high KI67 and HR - negative status among patients with HR - positive HER2 - negative EBC , patients with high TILs show a favorable 5 - year DFS in both HR - positive / HER2 - negative and triple - negative breast cancer . - pubmed
Activities of sulphatases A / B , sulphatase C , beta glucuronidase , acid and alkaline phosphatase were measured in 38 cases of colorectal cancer . - pubmed
We investigated the distribution and expression of mutant mtDNAs carrying the A - to - G mutation at position 8344 in the tRNA ( Lys ) gene in the skeletal muscle of four patients with myoclonus epilepsy and ragged - red fibers ( MERRF ) . - pubmed
The application of F - SSCP for detection of mutations and loss of heterozygosities of p53 in tumor tissues is reported . - pubmed
The children in P1 and P2A classes demonstrated an increase in CD8 + cells ; only the children with AIDS showed a significant decrease in CD4 + cells . - pubmed
[ Effects of the PAF antagonist WEB 2086 on hypoxia and angiotensin II - induced pulmonary vasoconstriction in the isolated perfused rat lung ] . - pubmed
Using isolated blood - perfused lung preparations of rats , we tested the influence of the PAF antagonist WEB 2086 on vasoconstriction triggered by hypoxia or angiotensin II ( A II ) . - pubmed
Effect of exercise training on insulin sensitivity and glucose metabolism in lean , obese , and diabetic men . - pubmed
To clarify the impact of vigorous physical training on in vivo insulin action and glucose metabolism independent of the intervening effects of concomitant changes in body weight and composition and residual effects of an acute exercise session , 10 lean , 10 obese , and 6 diet - controlled type II diabetic men trained for 12 wk on a cycle ergometer 4 h / wk at approximately 70 % of maximal O2 uptake ( VO2max ) while body composition and weight were maintained by refeeding the energy expended in each training session . - pubmed
Insulin sensitivity was not significantly altered by training in any group , but basal hepatic glucose production was reduced by 22 % in the diabetic men . - pubmed
Thus , when intervening effects of the last exercise bout or body composition changes were controlled , exercise training per se leading to increased cardiorespiratory fitness had no independent impact on insulin action and did not improve the insulin resistance in obese or diabetic men . - pubmed
Increased production of interleukin-1 ( IL-1 ) occurs following hemorrhage and thermal injury . - pubmed
Hemorrhage , accidental trauma and burns are followed by decreased interleukin-2 ( IL-2 ) generation . - pubmed
Production of interleukin-3 ( IL-3 ) and interleukin-5 ( IL-5 ) is diminished following hemorrhage . - pubmed
Gamma - interferon release appears to be increased following hemorrhage . - pubmed
Stress secondary to infection is accompanied by marked elevations in serum levels of tumor necrosis factor ( TNF ) , which contribute to hypotension and physiologic instability in this setting . - pubmed
Increased generation of IL-1 , and probably of TNF and IL-6 , contributes to the acute - phase reaction and hypermetabolic response which accompanies injury , burns , hemorrhage , and overwhelming infection . - pubmed
Severe immunosuppression , involving both T and B cell function , and contributing to the increased incidence of infection after injury may result , at least in part , from the multiple actions of stress - induced alterations in interleukin release . - pubmed
Subclasses of IgG H chain expressed in the rheumatoid synovium . - pubmed
We conclude that some patients of rheumatoid arthritis exhibit an increased level of a unique IgG subclass . - pubmed
We could demonstrate a high functional activity of fibroblasts with secretion of mucopolysaccharides and type III collagen around intraductal carcinomas . - pubmed
This paper reports on the diagnostic usefulness of two commercial PTH assay kits and four " in - house " assays using commercially available reagents , studying the same samples from normal controls and different patient groups . - pubmed
Patients with PTH secondary to chronic renal disease were well discriminated from normal by all assays . - pubmed
Although immunoassays are useful in many cases of 1 degree HPT , it is difficult to develop C - terminal or mid - region PTH assays that are uniformly diagnostically useful in the clinical situation where they are of greatest potential use i.e. - pubmed
[ Neutrophil elastase and the lung , with special reference to the pathogenesis of ARDS ] . - pubmed
Cultured human cells derived from pancreatic , gastric , duodenal , and gall bladder cancers secreted a considerable amount of pancreatic secretory trypsin inhibitor into the culture medium . - pubmed
Platelet associated complement components ( PAC3c and PAC3d ) in patients with autoimmune thrombocytopenia . - pubmed
Platelet associated C3c and C3d ( PAC3c and PAC3d ) were quantitated by enzyme linked assay in 105 patients with idiopathic autoimmune thrombocytopenia ( AITP ) in whom elevated platelet associated immunoglobulins ( IgG and IgM ) had previously been documented . - pubmed
The immunological disorders in patients with intestinal lymphangiectasia appear to result from loss of immunoglobulins and lymphocytes into the gastrointestinal tract secondary to disorders of lymphatic channels . - pubmed
Influence of naloxone on prolactin secretion in patients with acute and chronic renal failure . - pubmed
The influence of the opiate antagonist naloxone on chlorpromazine induced prolactin secretion was examined in 12 patients with acute renal failure ( ARF ) , 12 patients with chronic renal failure ( CRF ) and in 12 healthy subjects . - pubmed
In all examined groups naloxone showed a suppressive effect on chlorpromazine induced prolactin secretion , which was more accentuated in normals and patients with ARF then with CRF . - pubmed
The results of these investigations suggest that endogenous opiates may be of importance in the regulation of prolactin secretion both in normals and uremic patients . - pubmed
Pathophysiology of gastrointestinal trichostrongyles in sheep : plasma losses and changes in plasma pepsinogen levels associated with parasite challenge of immune animals . - pubmed
The incorporation of tritiated thymidine was significantly greater for lymphocytes from mice infected with the pathogenic Indonesian strain than for lymphocytes from mice infected with the non - pathogenic Formosan strain in response to SAA ; the responses also increased with duration of infection . - pubmed
Sensitivity and specificity of laboratory criteria , including CA 125 , compared unfavorably with others and are of no use in early diagnosis of ovarian malignancies . - pubmed
Proliferative responses of peripheral blood mononuclear cells from patients with Graves ' disease to synthetic peptides epitopes of human thyrotropin receptor . - pubmed
In Graves ' disease thyrotropin receptor ( TSH - R ) autoantibodies cause hyperthyroidism . - pubmed
These results suggest that ( a ) TSH - R - specific T cells are present in peripheral blood of patients with Graves ' disease , and ( b ) sequence segments 152 - 157 and 207 - 222 may be T cell epitopes of the human TSH - R in Graves ' disease . - pubmed
Generation of active oxygen forms ( GAOF ) by alveolar macrophages ( AM ) and leukocytes , the role of GAOF in provoking a bronchial asthma ( BA ) attack were studied simultaneously and compared in 10 asthmatics , 10 chronics with bronchitis and 5 healthy subjects . - pubmed
Both healthy subjects and the patients had GAOF by leukocytes more active than GAOF by AM , their proportion being less in asthmatics . - pubmed
This study noninvasively measured hemoglobin oxygen saturation in young ( n = 6 , 28 + /- 6 yrs ) , old healthy ( n = 20 , 68 + /- 7 yrs ) , and old subjects with mild peripheral vascular disease ( PVD ) ( n = 8 , 72 + /- 4 yrs ) . - pubmed
This neutralizing activity was absent in the IgG fractions prepared from sera of healthy volunteers , noninfected mice or mice killed at different times during acute T. cruzi infection . - pubmed
The presence of TIF - neutralizing antibodies during chronic but not acute T. cruzi infection may be one of the reasons why immunosuppression is confined to the acute stage . - pubmed
Many of the regulatory effects are mediated through the release of cytokines , a group of hormones that also promotes inflammation and replenishes hematopoietic elements . - pubmed
The various lymphocyte types within the adaptive immune system are interdependent , as evidenced by the X - linked hyper - IgM syndrome in which a T - cell deficiency ( CD40 ligand ) manifests clinically as an antibody production problem . - pubmed
We report a 6 - month longitudinal follow - up of biochemical markers of bone metabolism ( free and total deoxypyridinoline , total pyridinoline , N - telopeptide , osteocalcin , and total alkaline phosphatase ) and bone mineral densitometry in 30 subjects with acute SCI . - pubmed
Our results suggest that different sorting mechanisms for P - selectin are used in platelets and endothelial cells and that the storage pool of P - selectin in endothelial cells is functionally important during early stages of inflammation . - pubmed
Enhanced expression of interleukin-6 in chronic hepatitis C. - pubmed
AIMS / BACKGROUND : There is a possibility that proinflammatory cytokines such as interleukin-6 ( IL-6 ) are involved in the inflammatory process of chronic hepatitis C. - pubmed
This study was undertaken to investigate the possible role of IL-6 in the pathophysiology of chronic hepatitis C. - pubmed
METHODS : Serum IL-6 levels in 63 patients with chronic hepatitis C and in 26 normal controls were measured . - pubmed
RESULTS : Serum IL-6 levels were significantly ( p<0.01 ) elevated in chronic hepatitis C compared to those in normal controls . - pubmed
Pseudo - metabolic presentation in a Duchenne muscular dystrophy symptomatic carrier with ' de novo ' duplication of dystrophin gene . - pubmed
Upon immunofluorescence , a mosaic pattern of dystrophin deficiency was found , and in the dystrophin deficient muscle fibres , the four proteins of the sarcoglycan complex were also lacking . - pubmed
Inducible nitric oxide synthase ( iNOS ) was shown to be expressed in normal mucosa and adenoma of small and large intestines of Apc ( Min /+ ) mice by reverse transcription - PCR and immunohistochemistry . - pubmed
Administration of the iNOS inhibitor aminoguanidine ( 1.5 g / liter ) in drinking water or an L - arginine - deficient diet to Apc ( Min /+ ) mice resulted in a significant decrease in adenoma development in the small but not the large intestine . - pubmed
Similarly , iNOS - gene knockout Apc ( Min /+ ) mice ( Apc ( Min /+ ) iNOS(-/- ) or Apc(Min/+ ) iNOS(-/+ ) ) developed significantly fewer adenomas in both small and large intestines than Apc ( Min /+ ) iNOS (+/+ ) mice . - pubmed
These results suggest that iNOS - selective inhibitors could be used as a potential chemopreventive agent for colorectal cancers . - pubmed
SYT - SSX is critical for cyclin D1 expression in synovial sarcoma cells : a gain of function of the t(X;18)(p11.2;q11.2 ) translocation . - pubmed
The SYT - SSX fusion gene has been implicated in the malignant tumor cell growth of synovial sarcoma , but the underlying molecular mechanisms are still poorly understood . - pubmed
Here we demonstrate that SYT - SSX is critical for the protein level of cyclin D1 in synovial sarcoma cells . - pubmed
Taken together , our study provides evidence that SYT - SSX stabilizes cyclin D1 and is critical for cyclin D1 expression in synovial sarcoma cells . - pubmed
SYT - SSX - dependent expression of cyclin D1 may be an important mechanism in the development and progression of synovial sarcoma and also raises the possibility for targeted therapy . - pubmed
More importantly , Gp96 provides the first example of how the innate and adaptive immune system can be stimulated simultaneously by the same molecule which is released under physiological conditions from necrotic cells . - pubmed
Here , we demonstrate that the obligate intracellular parasite , Toxoplasma gondii , down - regulates activation - induced MHC class II expression in human - derived glioblastoma cells as well as in primary astrocytes and microglia from cortices of rat fetuses . - pubmed
MHC class II transcript levels induced by IFN - gamma alone or in combination with TNF - alpha were also clearly diminished after parasitic infection . - pubmed
[ Expression of urokinase - type plasminogen activator and its receptor protein in synovial tissues from osteoarthritis ] . - pubmed
OBJECTIVE : To study the expression of urokinase - type plasminogen activator ( uPA ) and its receptor ( uPAR ) in the synovial tissures , and the significance of uPA and uPAR in degradation of extracellular matrices in osteoarthritis ( OA ) , then analyse the possible relationship between uPA and uPAR . - pubmed
METHODS : Immunohistochemical analysis technique was used to detect uPA and uPAR protein expression and distribution in synovial tissues in 26 OA patients and 10 mormal individuals . - pubmed
RESULTS : Positive staining of uPA and uPAR protein were detected in 19 cases in the 26 OA samples ( 73 % ) , while only 2 positive cases were seen in the 10 mormal tissues ( 20 % ) . - pubmed
The expression rate of uPA protein was markedly higher in OA than in the normal ( P & lt ; 0.01 ) . - pubmed
The expression of uPAR was seen in 14 cases in all 26 OA samples ( 54.6 % ) , while there was only one case in 10 normal samples ( 10 % ) , the positive rate was significantly higher in OA than in normal samples ( P & lt ; 0.05 ) . - pubmed
Using the correction analysis , we found a positive correlation between uPA and uPAR reactivity in the synovial tissues in OA ( r = 0.920 , P & lt ; 0.01 ) . - pubmed
CONCLUSIONS : The high expression of uPA and uPAR protein in OA synovial tissues indicate that the uPA system may play an important role in the process of synovitis and degradation of OA cartilage extracellular matrices . - pubmed
In the pathologic process of OA , uPA and uPAR coordinate each other , lead to the genesis and development of OA cartilage degradation . - pubmed
In addition , a variety of genetic risk factors , such as factor V Leiden , protein S or C deficiency have also been identified . - pubmed
Notch and cancer : best to avoid the ups and downs . - pubmed
Two recent studies add to our understanding of Notch in cancer biology in contrasting ways , by showing novel mechanisms of Notch pathway activation in cancer cells , and by indicating that in some circumstances , Notch can behave as a tumor suppressor . - pubmed
[ Mechanism of the hypothermic action of insulin : hypoglycemia and disequilibrium of the plasma ions ] . - pubmed
We examined the potential possibility of an interaction between nicotine , a major component of cigarette smoke , and angiotensin II ( Ang II ) , which plays an important role in the pathogenesis of cardiovascular diseases characterized by Ang II type 1 ( AT1 ) receptor - mediated abnormal growth of vascular smooth muscle cells ( VSMC ) and fibroblasts . - pubmed
Increased expression of the epidermal growth factor ( EGF ) receptor ( EGFR ) and ErbB-2 is implicated into the development and progression of breast cancer . - pubmed
Mammary tumor cells that express low levels of both receptors or high levels of ErbB-2 and low levels of EGFR survive and proliferate in the presence of EGF . - pubmed
In contrast , fibroblastic cells or mammary tumor cells , which co - express high levels of EGFR and ErbB-2 invariably undergo apoptosis in response to EGF . - pubmed
Fibroblast growth factor receptor expression in aural polyps : predictor of cholesteatoma ? - pubmed
The cytokine , fibroblast growth factor ( FGF ) and its receptors ( FGFR ) have a pivotal role in wound repair and have been demonstrated in the perimatrix of active cholesteatoma . - pubmed
This study examines 28 archival aural polyp specimens , seeking an increased expression for FGFR1 and FGFR3 in polyps associated with cholesteatoma , when compared with those arising in non - cholesteatomatous , mucosal disease , but produced a null result . - pubmed
Rana catesbeiana ribonuclease ( RC - RNase ) possesses tumor - specific cytotoxicity , which can be synergized by IFN - gamma . - pubmed
Our findings provide evidence that RC - RNase and RC - RNase / IFN - gamma can kill different cancer cells by distinct mechanisms . - pubmed
Biochemical markers of prostate cancer risk such as prostate - specific antigen ( PSA ) and insulin - like growth factors ( IGFs ) were measured on plasma samples collected at enrollment and at the end of follow - up from 3,616 men . - pubmed
Among men with normal PSA , there was a marked statistically significant reduction in the rate of prostate cancer for men receiving the supplements ( hazard ratio = 0.52 ; 95 % CI = 0.29 - 0.92 ) . - pubmed
In men with elevated PSA at baseline , the supplementation was associated with an increased incidence of prostate cancer of borderline statistical significance ( hazard ratio = 1.54 ; 95 % CI = 0.87 - 2.72 ) . - pubmed
These results suggest that previously described hypotensive action of the beverage may be partly induced by the inhibition of angiotensin - converting enzyme . - pubmed
Rare missense variants in ATP1A2 in families with clustering of common forms of migraine . - pubmed
Familial hemiplegic migraine ( FHM ) is a rare monogenic subform caused by mutations in the calcium channel gene CACNA1A or the Na (+)/ K (+)- ATPase gene ATP1A2 . - pubmed
An involvement of FHM genes in the pathogenesis of common forms of migraine is not proven . - pubmed
We therefore systematically screened ATP1A2 in families with several members affected by MA and/or MO . - pubmed
In conclusion we propose that rare variants in ATP1A2 are involved in the susceptibility to common forms of migraine , because of 1 ) the absence of alterations in controls , 2 ) the particular pattern of segregation in both families , 3 ) the high conservation of mutated residues in Na (+)/ K (+)- ATPases , 4 ) the functional effect of C515Y , and 5 ) the involvement of ATP1A2 in a monogenic form of migraine . - pubmed
Anti - CD20 monoclonal antibody ( rituximab ) in the treatment of pemphigus . - pubmed
BACKGROUND : Pemphigus is a severe autoimmune blistering disorder caused by autoantibodies to desmoglein 1 and 3 . - pubmed
Bone mineral density and cytokine levels during interferon therapy in children with chronic hepatitis B : does interferon therapy prevent from osteoporosis ? - pubmed
BACKGROUND : Our aim was to determinate bone mineral density ( BMD ) , levels of biochemical markers and cytokines in children with chronic hepatitis B treated with interferon ( IFN )- alpha and to investigate effect of IFN - alpha therapy on these variables . - pubmed
To the best of our knowledge , this is first study carried out about BMD and cytokine levels in pediatric patients with chronic hepatitis B treated with IFN - alpha . - pubmed
METHODS : BMD , levels of parathyroid hormone ( PTH ) , osteocalcin , C - terminal cross - linking telopeptide of type I collagen ( CTX ) , calcium , alkaline phosphates ( ALP ) , cytokines as TNF - alpha , interleukin ( IL )- 1beta , IL-2r , IL-6 , and IL-8 were studied in 54 children with chronic hepatitis B ( 4 - 15 years old ) treated with interferon alone ( n = 19 ) or in combination with lamivudine ( n = 35 ) for six months and as controls in 50 age - matched healthy children . - pubmed
RESULTS : There was no significant difference in respect to serum IL-1beta , TNF - alpha and osteocalcin levels while serum IL-2r ( p = 0.002 ) , IL-6 ( p = 0.001 ) , IL-8 ( p = 0.013 ) , PTH ( p = 0.029 ) , and CTX ( p = 0.021 ) levels were higher in children with chronic hepatitis B than in healthy controls . - pubmed
CONCLUSION : In conclusion , our study suggest that BMD of femur , serum IL-2r , IL-6 , IL-8 , PTH , and CTX levels were higher in children with chronic hepatitis B treated with IFN - alpha alone or combination with lamivudine than in healthy children . - pubmed
High femur BMD measurements found in patients may suggest that IFN - alpha therapy in children with chronic hepatitis B could contribute indirectly to prevent from hip osteoporosis . - pubmed
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53 - dependent cellular senescence . - pubmed
Dysfunctional telomeres induce p53 - dependent cellular senescence and apoptosis , but it is not known which function is more important for tumour suppression in vivo . - pubmed
Tumour suppression is accompanied by global induction of p53 , p21 and the senescence marker senescence - associated - beta - galactosidase . - pubmed
CONCLUSIONS : Granulocyte colony - stimulating factor ( G - CSF ) , all - trans retinoic acid ( ATRA ) , and vaccines met 2 of 3 criteria for an association with SS . - pubmed
The mechanism of CD4(+ ) T - cell depletion in human immunodeficiency virus type 1 ( HIV-1 )- infected individuals remains unknown , although mounting evidence suggests that direct viral cytopathicity contributes to this loss . - pubmed
Enhanced invasive and metastatic potential induced by transforming growth factor - beta1 might be correlated with glutathione - S - transferase - pi , cofilin and heat shock protein 27 in SGC-7901 gastric cancer cells . - pubmed
In our previous study , we found that the transforming growth factor ( TGF )- beta1 enhanced the metastatic and invasive potential of gastric cancer cells . - pubmed
CONCLUSIONS : The combination of QD or BID treatment with MER+S was significantly more effective in lowering HbA ( 1c ) and glucose levels than sulfonylurea monotherapy in these adult patients with type 2 diabetes . - pubmed
On the other hand , chronic and dysregulated activation of some inducible enzymes , including NADPH oxidase ( NOX ) , inducible nitric oxide synthase ( iNOS ) and cyclooxygenase ( COX )- 2 , have been shown to play pivotal roles in the development of certain inflammatory diseases such as oncogenesis . - pubmed
Herein , the cancer preventive potentials of several food phytochemicals targeting the induction of NOX , iNOS and COX-2 are described . - pubmed
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis . - pubmed
TLRs may contribute to the progression of rheumatoid arthritis through recognition of microbial or host - derived ligands found in arthritic joints . - pubmed
Here , we show that TLR2 and TLR4 , but not TLR9 , are involved in the pathogenesis of autoimmune arthritis and play distinct roles in the regulation of T cells and cytokines . - pubmed
We investigated the involvement of TLR2 , TLR4 , and TLR9 in the progression of arthritis using IL-1 receptor antagonist - knockout ( IL1rn -/- ) mice , which spontaneously develop an autoimmune T cell - mediated arthritis . - pubmed
Spontaneous onset of arthritis was dependent on TLR activation by microbial flora , as germ - free mice did not develop arthritis . - pubmed
Clinical and histopathological evaluation of IL1rn-/-Tlr2-/- mice revealed more severe arthritis , characterized by reduced suppressive function of Tregs and substantially increased IFN - gamma production by T cells . - pubmed
IL1rn-/-Tlr4-/- mice were , in contrast , protected against severe arthritis and had markedly lower numbers of Th17 cells and a reduced capacity to produce IL-17 . - pubmed
A lack of Tlr9 did not affect the progression of arthritis . - pubmed
While any therapeutic intervention targeting TLR2 still seems complicated , the strict position of TLR4 upstream of a number of pathogenic cytokines including IL-17 provides an interesting potential therapeutic target for rheumatoid arthritis . - pubmed
BACKGROUND : This is a report of a patient with a novel genotype - phenotype relationship of a c804 mutation of the RET proto - oncogene manifesting as medullary thyroid carcinoma ( MTC ) and cutaneous lichen amyloidosis ( CLA ) . - pubmed
Role of two nutritional hepatic markers ( insulin - like growth factor 1 and transthyretin ) in the clinical assessment and follow - up of acute intermittent porphyria patients . - pubmed
RESULTS : Most of the serum proteins were within normal limits , however insulin - like growth factor 1 ( IGF-1 ) was decreased in 53.8 % of AIP patients ( z - score = -2.86 + /- 0.37 ) and transthyretin ( prealbumin ) was found significantly decreased in 38.5 % of them . - pubmed
We propose the use of both IGF-1 and transthyretin as biomarkers of disease morbidity / severity for the clinical follow - up of AIP patients . - pubmed
The effect of GH replacement after 2 years was assessed in those with available follow - up data ( 133 IGHD , 2207 MPHD ) , and development of new deficiencies in those with available data on concomitant medication ( 165 IGHD , 3006 MPHD ) . - pubmed
RESULTS : IGHD and MPHD patients had similar baseline clinical presentation , and both groups responded similarly to 2 years of GH therapy , with favourable changes in lipid profile and improved quality of life . - pubmed
CONCLUSION : Both AO - IGHD and -MPHD patients have similar baseline clinical presentation and respond equally well to 2 years of GH replacement . - pubmed
Expression of p53 , c - erbB-2 and Ki67 in intestinal metaplasia and gastric carcinoma . - pubmed
Forty - seven IM and thirty - seven gastric carcinoma samples were stained for p53 , c - erbB-2 and Ki67 proteins by Envision immunohistochemical technique . - pubmed
RESULTS : There were no significant differences in the expression of p53 and c - erbB-2 among type I , type II , type III IM and gastric carcinomas . - pubmed
The positive expression rate of Ki67 was significantly higher in gastric carcinomas than in type I IM while no significant Ki67 expression differences were observed among type II , type III IM and gastric carcinomas . - pubmed
The expression of p53 , c - erbB-2 and Ki67 proteins in 20 SIM , 27 Atypical IM and 37 gastric carcinomas showed significant differences between SIM and gastric carcinomas while no significant differences were observed between Atypical IM and gastric carcinomas . - pubmed
Blood centers are implementing TRALI risk reduction strategies based on screening apheresis donors for antibodies to human leukocyte antigens ( HLA ) . - pubmed
Effect of TIMP-1 and MMP in pterygium invasion . - pubmed
The migration and invasion of tumor cells correlate with the interaction between MMP and TIMP . - pubmed
Therefore , the purpose of this study was to determine the role of MMP-9 , MMP-10 , and TIMPs in pterygium formation and progression . - pubmed
Pterygium epithelial cells ( PECs ) , cultured in a serum - free culture medium , and siRNA were used to knock down TIMP gene expression to understand the role of TIMP in pterygium invasion . - pubmed
MMP-9 and MMP-10 may each play a role in pterygium formation , and TIMPs may contribute to pterygium invasion inhibition . - pubmed
METHODS : In the acute myocardial ischemia model , 40 Sprague - Dawley rats ( 8 weeks old , weight 200 - 250 g ) were successfully established with isoproteronol ( ISO ) and randomly and evenly divided into 4 groups : Group G ( injected with glycosylated G - CSF ) , Group N ( non - glycosylated G - CSF ) , Group C ( [ control ] normal saline for 7 days ) , and Group M ( model ) . - pubmed
At day 28 , the proportion of CD34 + cells , myocardial BrdU immunohistochemical stain , myocardial capillary density , myocardial fibrosis and cardiac function was detected among the 3 groups . - pubmed
There are bases to think that aldose reductase and Bcl-2 protein are claimants to the role of end - effectors of delayed preconditioning but microRNAs serve as mediators of forming increased cardiac tolerance to ischemia - reperfusion . - pubmed
Chemokine - containing exosomes are released from heat - stressed tumor cells via lipid raft - dependent pathway and act as efficient tumor vaccine . - pubmed
In the immunoglobulin ( Ig ) M - positive stage of infection in blood donors when plasma B19V DNA concentrations were greater than 100 IU / mL , median DNA concentrations were approximately 30 - fold higher in WB than in plasma . - pubmed
CONCLUSIONS : The WB - to - plasma B19V DNA ratio varies by stage of infection , with 30 - fold higher concentrations of B19V DNA in WB relative to plasma during the IgM - positive stage of infection followed by comparable levels during persistent infection when only IgG is present . - pubmed
Since then , no primary thyroid small - cell carcinoma has been reported in the literature , with the exception of a case of a small - cell ( neuroendocrine ) carcinoma , an exceedingly rare neoplasm akin to medullary carcinoma , with expression of neuroendocrine markers but lacking calcitonin immunoreactivity . - pubmed
Beneficial effect of the opioid receptor antagonist naltrexone on hyper - sensitivity induced by spinal cord ischemia in rats : disassociation with MK-801 . - pubmed
However , even the effect of the highest dose of naltrexone ( 20 mg / kg ) was incomplete , which is in contrast to the effect of the NMDA receptor antagonist MK-801 , which has been tested in the same model and found to completely prevent the incidence of allodynia at a dose of 0.5 mg / kg . - pubmed
The results suggest that opioid receptor antagonists and NMDA receptor antagonists prevent a consequence of transient spinal cord ischemia through different mechanisms . - pubmed
On the other hand , the NMDA receptor may have a role in the secondary neuronal death resulting from ischemia . - pubmed
Thus , NMDA receptor antagonists may contribute to the prevention of tissue damage by antagonizing the excitotoxic action of glutamate and/or aspartate released by ischemia into the spinal cord . - pubmed
Tissue factor over - expression by human pancreatic cancer cells BXPC3 is related to higher prothrombotic potential as compared to breast cancer cells MCF7 . - pubmed
Cancer histology influences the risk of venous thromboembolism and tissue factor ( TF ) is the key molecule in cancer - induced hypercoagulability . - pubmed
We investigated the relation between TF expression by pancreatic and breast cancer cells ( BXPC3 and MCF7 respectively ) and their capacity to trigger in vitro thrombin generation in normal human plasma . - pubmed
Activity of TF expressed by cancer cells was measured with a specific chromogenic assay . - pubmed
The present study establishes a link between the amount of TF expressed by cancer cells with their procoagulant activity . - pubmed
Both studied types of cancer cells trigger thrombin generation but they have different procoagulant potential . - pubmed
TF expression is one of the mechanisms by which cancer cells manifest their procoagulant potential but it is not the unique one . - pubmed
Collectively , our findings provide a proof - of - concept for the ability of man - made NPs to induce insulin resistance in liver - derived cells , an endocrine abnormality underlying some of the most common human diseases . - pubmed
[ Effect of NR2E1 on the division and proliferation of neuroblastoma cells ] . - pubmed
RESULTS : At 48 h after the neuroblastoma cells IMR32 were transfected with NR2E1 - shiRNA vector , the related nuclear division protein and the proliferation of the transfected cells IMR32 were remarkably depressed . - pubmed
To examine the diagnostic performance of cerebrospinal fluid - enzyme immunoassay ( CSF - EIA ) in neurosyphilis , we conducted a prospective study for two years . - pubmed
SIL1 , a causative cochaperone gene of Marinesco - Sojgren syndrome , plays an essential role in establishing the architecture of the developing cerebral cortex . - pubmed
Recently , mutations in the SIL1 gene , encoding a co - chaperone which regulates the chaperone HSPA5 , were identified as a major cause of MSS . - pubmed
We here examined the pathophysiological significance of SIL1 mutations in abnormal corticogenesis of MSS . - pubmed
While RNAi - resistant SIL1 rescued the defects , three MSS - causing SIL1 mutants tested did not . - pubmed
Redistribution of demethylated RNA helicase A during foot - and - mouth disease virus infection : role of Jumonji C - domain containing protein 6 in RHA demethylation . - pubmed
CCL2 [ chemokine ( C - C motif ) ligand 2 ] contributes to the inflammation - induced neuropathic pain through activating VGSC ( voltage - gated sodium channel)-mediated nerve impulse conduction , but the underlying mechanism is currently unknown . - pubmed
Fibrin is a protein polymer that forms a 3D filamentous network , a major structural component of protective physiological blood clots as well as life threatening pathological thrombi . - pubmed
Once mostly considered inexorable , renal disease progression can now be halted and lesions can even regress with drugs such as angiotensin - converting enzyme inhibitors ( ACEi ) and angiotensin II type I receptor blockers , indicating the possibility of kidney repair . - pubmed
The CXCR4 / SDF-1 and Ang II / AT1 receptor pathogenic pathways both pave the way for lesion formation and subsequent sclerosis . - pubmed
ACEi normalize the CXCR4 and AT1 receptor expression on progenitors , limiting their proliferation , concomitant with the regression of hyperplastic lesions in animals , and in a patient with crescentic glomerulopathy . - pubmed
Moreover an increase of CYP1A1 ( homologue to human CYPIA 1 ) mRNA level may not only reduce the carcinogenicity of foreign compounds , but may also activate some compounds to their carcinogenicity In case of transporters , it is considered that an increase of their expression in the body may lead to increased fetoprotection . - pubmed
Antioxidant status and serum levels of selectins in pre - eclampsia . - pubmed
In patients over the age of 30 years , serum levels of L - selectin and E - selectin were lower in pre - eclamptic patients ( p & lt ; 0.05 ) ; antioxidants , catalase and superoxide dismutase did not significantly differ between the two groups , while glutathione peroxidase was significantly higher in the normotensive group ( p & lt ; 0.05 ) . - pubmed
In patients under the age of 30 years , E - selectin was significantly higher in the pre - eclampsia group ( p & lt ; 0.05 ) , while P - selectin , catalase and superoxide dismutase were not significantly different between the two groups ( p & gt ; 0.05 ) . - pubmed
Estrogens are known that they may produce breast cancer by actions on ER and also as chemical carcinogens , as a consequence of their oxidation leading to reactive metabolites . - pubmed
Renal fibrosis is mainly characterized by activation and proliferation of interstitial fibroblasts and by excessive synthesis and accumulation of extracellular matrix ( ECM ) components , including fibronectin ( FN ) and collagen . - pubmed
These results suggest that curcumin treatment ameliorates renal fibrosis by reducing fibroblast proliferation and ECM accumulation mediated by PPAR - gamma and Smad - dependent TGF - beta1 signaling . - pubmed
Additionally , there were no detectable increases in the number of necrotic muscle fibers or CD68 + M1 macrophages . - pubmed
Under EE - challenged conditions , significant increases in muscle fiber necrosis , CD68 + M1 macrophage distribution , and 3 - nitrotyrosine were absent in rats that received low and medium doses ( 20 and 60 mg / kg ) of DS treatment , suggesting that DS possess anti - inflammatory action protecting against a muscle - damaging challenge . - pubmed
NKT cell - targeted vaccination plus anti-4 - 1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma . - pubmed
The objective of this study was to increase the potency and durability of vaccine - induced immunity against B cell lymphoma by combining alpha - galactosylceramide ( alpha - GalCer)-loaded tumor cell vaccination with an agonistic antibody targeting the immune checkpoint molecule 4 - 1BB ( CD137 ) . - pubmed
We observed potent synergy when combining vaccination and anti-4 - 1BB antibody treatment resulting in significantly enhanced survival of mice harboring Emu - myc tumors , including complete eradication of lymphoma in over 50 % of mice . - pubmed
Tumor - free survival required interferon gamma ( IFNgamma)-dependent expansion of CD8 + T cells and was associated with 4 - 1BB - mediated differentiation of KLRG1 + effector CD8 + T cells . ' - pubmed
Overall , our results demonstrate that therapeutic anticancer vaccination against B cell lymphoma using an NKT cell ligand can be boosted by subsequent co - stimulation through 4 - 1BB leading to a sustainable immune response that may enhance outcomes to conventional treatment . - pubmed
There is great success using HLA - matched related donors for these patients ; however , the use of alternative donors has been associated with increased graft failure , graft - versus - host disease ( GVHD ) , and transplant - related mortality ( TRM ) . - pubmed
HSCT using alternative donors with post - transplantation cyclophosphamide ( PT / Cy ) for GVHD prophylaxis has been performed for hematologic malignancies with engraftment , GVHD , and TRM comparable with that seen with HLA - matched related donors . - pubmed
miR-181a negatively regulates NF - kappaB signaling and affects activated B - cell - like diffuse large B - cell lymphoma pathogenesis . - pubmed
Remarkably , these effects are augmented in the NF - kappaB dependent ABC - like subgroup compared with the GC B - cell ( GCB)-like DLBCL subgroup . - pubmed
We link these outcomes to relatively lower endogenous miR-181a expression and to NF - kappaB signaling dependency in the ABC - like DLBCL subgroup . - pubmed
Our findings indicate that miR-181a inhibits NF - kappaB activity , and that manipulation of miR-181a expression in the ABC - like DLBCL genetic background may result in a significant change in the proliferation and survival phenotype of this malignancy . - pubmed
Association between two single base polymorphisms of intercellular adhesion molecule 1 gene and inflammatory bowel disease . - pubmed
AIM : The present study evaluated the association between G241R and K469E polymorphisms of intercellular adhesion molecule 1 gene and inflammatory bowel disease in Iranian population . - pubmed
There are two single base polymorphisms of intercellular adhesion molecule 1gene , G241R and K469E , reported to be associated with inflammatory disorders . - pubmed
CONCLUSION : According to our findings , K469E polymorphism of intercellular adhesion molecule 1 gene may probably participate in the pathogenesis of Crohn ' s disease in Iran . - pubmed
NAFLD was independently associated with BMI more than 25 kg / m [ adjusted odds ratio ( aOR ) 4.86 , 95 % confidence interval ( CI ) 2.55 - 9.26 ] and elevated alanine aminotransferase ( ALT ) ( aOR 3.17 , 95 % CI 1.43 - 7.03 ) . - pubmed
Independent predictors of significant liver fibrosis were diabetes ( aOR 5.84 , 95 % CI 1.91 - 17.85 ) , elevated ALT ( aOR 3.30 , 95 % CI 1.27 - 8.59 ) and current use of protease inhibitors ( aOR 3.96 , 95 % CI 1.64 - 9.54 ) . - pubmed
Lower Erythropoietin Doses and Medicare Payment Reform : Win - Wins for Patients With End - stage Renal Disease . - pubmed
NLRP3 inflammasome : common nexus between depression and cardiovascular diseases . - pubmed
IgE - ADA was determined in three retrospective cohorts ( n=159 ) containing IR+ ( n=37 ) and IR- ( n=39 ) , and longitudinal sera of 83 spondyloarthritis . - pubmed
RESULTS : IgE - ADA was found in 0/39 IR- , whereas 4/37 ( 11 % ) IR+ showed low levels ( 0.1 - 0.3 IU / mL , below the 0.35 IU / mL threshold associated with elevated risk of allergic symptoms ) . - pubmed
The incidence of IgE - ADA in patients with infliximab - treated spondyloarthritis was estimated at less than approximately 1 % . - pubmed
High expression of EphA3 ( erythropoietin - producing hepatocellular A3 ) in gastric cancer is associated with metastasis and poor survival . - pubmed
BACKGROUND : As the major subfamily of receptor tyrosine , erythropoietin - producing hepatocellular ( Eph ) receptor has been related to progression and prognosis in different types of tumors . - pubmed
However , the role and mechanism of EPHA3 in gastric cancer is still not well understood . - pubmed
We analyzed the clinicopathological factors and prognostic relevance of EphA3 expression in gastric cancer . - pubmed
RESULTS : High expression of EphA3 was associated with male predominance ( p = 0.031 ) , differentiated histology ( p & lt ; 0.001 ) , depth of tumor ( p = 0.002 ) , lymph node metastasis ( p = 0.001 ) , distant metastasis ( p = 0.021 ) , liver metastasis ( p = 0.024 ) , advanced stage ( p & lt ; 0.001 ) , and high HER2 expression ( p = 0.017 ) . - pubmed
Multinomial logistic regression estimated separate ORs for each subtype by the exposures parity , age at first birth , breastfeeding , menarche , hormone replacement therapy use , somatotype at age 18 , benign breast disease , mammographic density , polygenic risk score , family history of breast cancer , and BRCA mutations . - pubmed
The new kisspeptin derivative - kissorphin ( KSO ) - attenuates acute hyperlocomotion and sensitization induced by ethanol and morphine in mice . - pubmed
Previous studies of monoHAA - induced genotoxicity and cell stress demonstrated that the toxicity was due to inhibition of glyceraldehyde-3 - phosphate dehydrogenase ( GAPDH ) , leading to disruption of cellular metabolism and energy homeostasis . - pubmed
Hepatitis B virus infection in Taiwan : The role of NTCP rs2296651 variant in relation to sex . - pubmed
Sodium taurocholate cotransporting polypeptide ( NTCP ) is a functional receptor for hepatitis B virus ( HBV ) infection . - pubmed
Gender - stratified multivariate logistic regression models were used to determine the relationship between NTCP variant and HBV infection . - pubmed
We found that genetic variation in the HBV receptor gene ( NTCP ) was significantly associated with a decreased risk of HBV infection in Taiwanese women . - pubmed
HIV - related parameters such as CD4 cell counts , duration of HIV infection and HAART regimen did not seem to contribute towards an adverse surgical outcome . - pubmed
Background : Angelman syndrome is a rare neurodevelopmental disorder characterized by intellectual disability , severe speech impairment , ataxia , seizures , happy demeanor , distinctive craniofacial features , high vagal tone , and gamma - amino butyric acid receptor abnormalities . - pubmed
Transmembrane - type 2 matrix metalloproteinase ( MT2 - MMP ) degrades connective extracellular matrix between cells and enables tumor cells to migrate and metastasize , making this substance a potential therapeutic target in various diseases . - pubmed
This work illustrated that common trivalent metal ions can potentially inhibit MT2 - MMP - related tumors . - pubmed
Risk stratification and role for additional diagnostic testing in patients with acute chest pain and normal high - sensitivity cardiac troponin levels . - pubmed
BACKGROUND : Normal high sensitivity cardiac troponin ( hs - cTn ) assays rule out acute myocardial infarction ( AMI ) with great accuracy , but additional non - invasive testing is frequently ordered . - pubmed
METHODS : 918 serial patients with acute chest pain and normal hs - cTnT levels were prospectively included . - pubmed
A recent abnormal stress test , suspicious history , a positive family history and higher baseline hs - cTnT levels were independent predictors of MACE with odds ratios of 16.00 ( 95%CI:6.25 - 40.96 ) , 16.43 ( 6.36 - 42.45 ) , 2.33 ( 1.22 - 4.42 ) and 1.10 ( 1.01 - 1.21 ) , respectively . - pubmed
CONCLUSIONS : Clinical characteristics can be used to identify low risk patients with acute chest pain and normal hs - cTnT levels . - pubmed
MMP9 is an inflammatory biomarker that increases during progression to endometriosis . - pubmed
Author Correction : Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia . - pubmed
Serum PG levels were positively correlated with metagenomic functional capacities for bacterial LPS synthesis and host markers of low - grade inflammation ; transcriptome databases identified PG synthase , the first committed enzyme in PG synthesis , as a potential mediator . - pubmed
Furthermore , during oral glucose and insulin tolerance tests , FO from dyslipidaemic dams exhibited altered glucose tolerance and insulin sensitivity ( P & lt ; 0.05 ) when compared with FO from CTL dams . - pubmed
In such conditions , rocuronium remains able to cause immunoglobulin E cross - linkage and the anaphylaxis mechanism can continue . - pubmed
Intradermic skin tests confirmed rocuronium immunoglobulin E - mediated anaphylaxis but also showed intradermal injection of mixing in equal molecular ratio of sugammadex with rocuronium preventing rocuronium anaphylactic skin reaction . - pubmed
BACKGROUND : The apolipoprotein E ( APOE ) genotype provides information about Alzheimer ' s disease risk , yet genotype disclosure is discouraged due to concerns about possible distress . - pubmed
Circular RNA ciRS-7 promotes the proliferation and metastasis of pancreatic cancer by regulating miR-7 - mediated EGFR / STAT3 signaling pathway . - pubmed
ciRS-7 expression was also significantly elevated in venous invasion ( 3.72 + - 2.93 vs. 2.14 + - 1.26 ; P = 0.028 ) and lymph node metastasis ( 4.19 + - 2.75 vs. 2.32 + - 1.90 ; P = 0.016 ) in PDAC patients . - pubmed
Furthermore , ciRS-7 knockdown suppressed cell proliferation and invasion of PDAC cells ( P & lt ; 0.05 ) , and the downregulation of ciRS-7 resulted in miR-7 overexpression and subsequent inhibition of epidermal growth factor receptor ( EGFR ) and signal transducer and activator of transcription 3 ( STAT3 ) . - pubmed
CONCLUSIONS : Circular RNA ciRS-7 plays an oncogene role in PDAC , partly by targeting miR-7 and regulating the EGFR / STAT3 signaling pathway . - pubmed
Triglyceride deposit cardiomyovasculopathy ( TGCV ) is a phenotype primarily reported in patients carrying genetic mutations in PNPLA2 encoding adipose triglyceride lipase ( ATGL ) which releases long chain fatty acid ( LCFA ) as a major energy source by the intracellular TG hydrolysis . - pubmed
Moreover , we identified TGCV patients without PNPLA2 mutations based on pathological and clinical studies . - pubmed
We provided the diagnostic criteria , in which TGCV with and without PNPLA2 mutations were designated as primary TGCV ( P - TGCV ) and idiopathic TGCV ( I - TGCV ) , respectively . - pubmed
Patients with I - TGCV , of which etiologies and causes are not known yet , suffered from adult - onset severe heart disease , including heart failure and coronary artery disease , associated with a marked reduction in ATGL activity and myocardial washout rate of LCFA tracer , as similar to those with P - TGCV . - pubmed
The lymphocytes from bone marrow of multiple myeloma patients as well as myeloma cell lines - RPMI 8226 and U266 B1 express APase activity constitutively . - pubmed
We investigated the distribution and progression of LRP and its relation to AD pathology and apolipoprotein ( APOE ) epsilon4 in a population - based sample of Finns aged over 85 years ( N = 304 ) . - pubmed
LRP was present in 124 individuals ( 41 % ) and according to DLB Consortium guidelines 19 of them were categorized as brainstem , 10 amygdala - predominant , 41 limbic , and 43 diffuse neocortical type , whereas 11 could not be classified . - pubmed
Severe Braak NFT stage , high CERAD score and APOE epsilon4 were significantly ( all p & lt ; 0.00001 ) associated with amygdala - based , but not with caudo - rostral progression type ( all p & gt ; 0.2 ) . - pubmed
The amygdala - based pattern was associated with APOE epsilon4 and AD pathology . - pubmed
Netrin-1 and its receptor DCC are causally implicated in melanoma progression . - pubmed
Deleted in Colorectal Cancer ( DCC ) , the receptor for the multifunctional cue netrin-1 , acts as a tumor suppressor in intestinal cancer and lung metastasis by triggering cancer cell death when netrin-1 is lowly expressed . - pubmed
Recent genomic data highlighted that DCC is the third most frequently mutated gene in melanoma , we therefore investigated whether DCC could act as a melanoma tumor suppressor . - pubmed
Re - expressing DCC in human melanoma cell lines promoted tumor cell death and tumor growth inhibition in xenograft mouse models . - pubmed
Genetic silencing of DCC pro - death activity in a BRAFV600E mouse model increased the proportion of mice with melanoma , further supporting that DCC is a melanoma tumor suppressor . - pubmed
Netrin-1 expression was elevated in melanoma compared to benign melanocytic lesions . - pubmed
Upregulation of Netrin-1 in the skin cells of a BRAFV600E - mutated murine model reduced cancer cell death and promoted melanoma progression . - pubmed
Therapeutic antibody blockade of netrin-1 combined with dacarbazine increased overall survival in several mouse melanoma models . - pubmed
Together these data support that interfering with netrin-1 could be a viable therapeutic approach in patients with netrin-1 - expressing melanoma . - pubmed
More recently , advancement in molecular exploration of BTC has shed light on the complex biological heterogeneity within these tumours and has also identified actionable genomic aberrations , such as fibroblast growth factor receptor 2 ( FGFR2 ) gene fusions , isocitrate dehydrogenase ( IDH ) and BRAF mutations , which offer promise with the anticipation of increased responses and durable clinical benefit in selected patients . - pubmed
The origin of PNH is the somatic mutation in the X - linked phosphatidylinositol glycan class A ( PIG - A ) gene located on Xp22 : this condition leads to the production of clonal blood cells with a deficiency in those surface proteins that protect against the lytic action of the activated complement system . - pubmed
A human induced pluripotent stem cell ( iPSC ) line was generated from peripheral blood mononuclear cells ( PBMCs ) in a patient with intellectual disability and carrying a haploinsufficiency for PLPPR4 . - pubmed
This iPSC line offers a useful resource to investigate the pathogenesis and molecular mechanisms involved in PLPPR4 - related ID . - pubmed
Nlrp3 inflammasome , a key contributor in the pathogenesis of angina pectoris , requires activation and primary signaling for the commencement of inflammation . - pubmed
Morphine-3 - glucuronide upregulates PD - L1 expression via TLR4 and promotes the immune escape of non - small cell lung cancer . - pubmed
Methods : The effects of M3 G on PD - L1 expressions in human non - small cell lung cancer ( NSCLC ) cell lines were first evaluated . - pubmed
The effects of M3 G on human cytotoxic T lymphocytes ( CTL ) cytotoxicity and INF - gamma release was also detected . - pubmed
M3 G inhibited the cytotoxicity of CTL on A549 cells and decreased the level of INF - gamma . - pubmed
Repeated M3 G intraperitoneal injections promoted LLC tumor growth and lung metastasis through the upregulation of tumor expressed PD - L1 and the reduction of CTL in the tumor microenvironment . - pubmed
Conclusions : M3 G specifically activated TLR4 in NSCLC cells and upregulated PD - L1 expression through the PI3 K signaling pathway , thereby inhibiting CTL cytotoxicity and finally promoting tumor immune escape . - pubmed
Concanavalin A inhibition of ecto-5 '- nucleotidase of intact cultured C6 glioma cells . - pubmed
A pronounced effect of concanavalin A ( Con A ) upon activity of ecto-5 '- nucleotidase of intact C6 glioma cells in culture has been demonstrated . - pubmed
Preincubation at 42 degrees , before infection at permissive temperature by phage lambda , of an Escherichia coli dnaB mutant , provokes a significant increase in survival and mutagenesis of ultraviolet irradiated phage as well as mutagenesis of untreated phage . - pubmed
Abnormal lipoprotein - lipase - mediated plasma triglyceride removal in untreated diabetes mellitus associated with hypertriglyceridemia . - pubmed
An abnormality in the interaction of lipoprotein lipase with endogenous circulating plasma lipoprotein triglyceride has been demonstrated in untreated diabetes . - pubmed
These diabetics have a decreased maximal removal capacity for plasma triglyceride ( 27.0 mg TG / kh / hr ) and increased Km ( 390 mg / dl ) for endogenous plasma triglyceride - lipoprotein lipase interaction compared to that found in nondiabetic hypertriglyceridemic subjects ( Vmax , 32.0 ; km , 157 ) . - pubmed
The double - stranded RNA - dependent 2 ' , 5 '- oligoadenylate ( 2 - 5A ) synthetase / ribonuclease L ( RNase L ) system plays an essential role in the establishment of the antiviral state of a cell exposed to virus infection . - pubmed
Two new strategies have been developed which yield a selective antiviral effect of 2 - 5As at least against human immunodeficiency virus-1 ( HIV-1 ) infection : ( i ) an " intracellular immunization " approach using 2 - 5A synthetase cDNA linked to HIV trans - acting response element ( TAR ) and ( ii ) inhibition of retroviral reverse transcriptase activity by 2 - 5A analogues . - pubmed
Intracerebroventricular infusions of insulin ( 4 and 40 micrograms / min for 30 min ) increased plasma AVP concentrations dose - dependently without hypoglycaemia , but decreased hypothalamic and pituitary contents of AVP . - pubmed
The decreased threshold for strychnine - induced seizures and myoclonus in the 3AP - inferior olive - lesioned rats may be due to an increase in glutamate receptors as suggested by the [ 3H ] AMPA binding data . - pubmed
Thus : beta - adrenergic receptor density increases during relatively early stages of injury in metabolically impaired myocytes with reduced adenosine triphosphate levels and decreases subsequently , after the myocytes become irreversibly injured ; the increased beta - adrenergic receptor density in moderately injured myocytes can be reversed upon removal of the injurious agent and restoration of the cellular adenosine triphosphate level ; and changes in catecholamines mediated by an intact nervous system are not required for an increase in beta - adrenergic receptor density in the setting of impaired energy metabolism . - pubmed
Site - specific mutagenesis was used to introduce amino acid substitutions at the asparagine codons of four conserved potential N - linked glycosylation sites within the gp120 envelope protein of human immunodeficiency virus ( HIV ) . - pubmed
[ Application of fibrin adhesive in the surgery of complex renal lithiasis ] . - pubmed
It has been shown previously that the amyloid fibrils in one form of senile amyloidosis affecting the heart contains a prealbumin - related protein , ASc1 . - pubmed
It is shown in this paper by immunohistochemical study using a specific anti - protein ASc1 antiserum that this type of amyloidosis , previously called senile cardiac amyloidosis , is a systemic disease with amyloid deposits in many organs . - pubmed
Evidence for a differential modulation of the alpha-2 adrenoceptors by angiotensin II in the nucleus tractus solitarii of the spontaneously hypertensive and the Wistar - Kyoto normotensive rats . - pubmed
An interaction between angiotensin II ( Ang II ) receptors and alpha 2 - adrenoceptors was evaluated in the nucleus tractus solitarii ( NTS ) of the normotensive Wistar - Kyoto rat ( WKY ) and of the spontaneously hypertensive rat ( SHR ) using quantitative receptor autoradiography and cardiovascular analysis . - pubmed
Tamoxifen is widely used as adjuvant therapy for postmenopausal breast cancer patients with positive estrogen receptors . - pubmed
It may be concluded that relaxations elicited by hypercapnic acidosis are associated with a fall of extracellular pH and an activation of the electrogenic Na + pump , and those caused by hyperosmolarity are due to stimulation of the Na(+)-H+ exchange and the Na+ pump . - pubmed
IgE - mediated allergy from vegetable allergens . - pubmed
Allergy to fresh fruits and vegetables is IgE - mediated . - pubmed
Fluorescence in situ hybridization ( FISH ) with satellite ( alpha , beta , classical ) , ribosomal DNA , alpha - interferon ( alpha - IFN ) , and whole chromosome painting probes indicated that the 9;15 rearrangement is dicentric in both tumors . - pubmed
Detection of albumin messenger RNA in blood is not restricted to hepatocellular carcinoma . - pubmed
Protein kinase C ( PKC ) regulates keratinocyte growth and differentiation as well as inflammation in skin , processes which are abnormal in skin diseases such as psoriasis . - pubmed
We investigated the effects of SCH 47112 , a novel staurosporine derivative , which interacts with the catalytic domain of PKC , on TPA - induced inflammation and hyperplasia in hairless mouse skin and TPA - induced differentiation in cultured human keratinocytes . - pubmed
These results indicate that SCH 47112 exhibits biological activity , inhibiting TPA - induced changes in hairless mouse skin in vivo and cultured human keratinocytes in vitro , and suggest that PKC inhibitors may have a therapeutic role in inflammatory skin diseases . - pubmed
Decrease in circulating and urine adrenomedullin concentrations in stroke - prone spontaneously hypertensive rats . - pubmed
Adrenomedullin ( AM ) is a peptide with potent vasodilatory and hypotensive properties . - pubmed
Effects of poly ( ADP - ribose ) polymerase inhibition on cell death and chromosome damage induced by VP16 and bleomycin . - pubmed
Since apoptosis is important in tumor treatment these findings might be useful when considering the combined employment of PARP inhibition with antineoplastic drugs . - pubmed
Expression of the 67 - kDa laminin receptor in acute myeloid leukemia cells mediates adhesion to laminin and is frequently associated with monocytic differentiation . - pubmed
The 67 - kDa laminin receptor ( 67LR ) is a nonintegrin protein with high affinity for laminin , which plays a critical role in basement membrane invasion and metastasis of cancer cells . - pubmed
We did not detect 67LR expression in normal BM hematopoietic cells , in precursor - B acute lymphoblastic leukemia , in chronic lymphocytic leukemia , or in chronic myeloid leukemia in chronic phase . - pubmed
By contrast , we detected enhanced 67LR expression in 40 % of 53 de novo acute myeloid leukemias ( AMLs ) , which frequently exhibited monocytic or myelomonocytic morphology and expressed CD14 and CD11a ( P & lt ; 0.05 ) . - pubmed
Using a colorimetric assay , we found that the expression pattern of this receptor corresponded to a higher adhesion to laminin ; the adhesion was specific because in vitro addition to laminin - coated wells of recombinant 37 - kDa laminin receptor precursor ( 37LRP ) , which is the cytoplasmic precursor containing both laminin - binding domains of cell surface 67LR , significantly reduced laminin binding of AML cells . - pubmed
The expression of 67LR on AML cell surface did not correlate with other differentiation and integrin antigens such as CD7 , CD13 , CD33 , CD34 , CD11b , CD11c , CD49d , CD49e , CD45RA , and CD45RO . - pubmed
In contrast with 67LR behavior in solid tumors , no statistically significant difference was found between 67LR expression and any hematological characteristic of the disease at diagnosis , nor between 67LR expression and outcome of the disease as measured by complete remission rate , disease - free survival , or overall survival . - pubmed
In conclusion , our results indicate that 67LR expression mediates specific adhesion to laminin and that the detection of this molecule may be a valuable addition to other lineage - associated antigens in identifying monocytic - oriented AML . - pubmed
Endothelial NO synthase ( eNOS ) generated NO ( 140 + /- 20 nmol l(-1 ) ) in lung during the acute phase ( first 10 - 15 min ) of endotoxemia , followed by production of NO by inducible NOS . - pubmed
Severe hypoglycemia and reduction of insulin requirement in a girl with insulin - dependent diabetes mellitus : first sign of a craniopharyngioma . - pubmed
At 16 years she was found to have GH , gonadotropin , ACTH , and probably also TSH deficiency with hyperprolactinemia . - pubmed
In this girl , decreasing insulin requirements represented an early manifestation of combined growth hormone and cortisol deficiency . - pubmed
KCNQ4 , a K+ channel mutated in a form of dominant deafness , is expressed in the inner ear and the central auditory pathway . - pubmed
Mutations in the potassium channel gene KCNQ4 underlie DFNA2 , an autosomal dominant form of progressive hearing loss in humans . - pubmed
Moreover , the expression pattern of KCNQ4 in the mouse auditory system raises the possibility of a central component in the DFNA2 hearing loss . - pubmed
It has been reported that survivin is expressed during fetal development and in cancer tissues , but its expression has not been reported in adult tissues . - pubmed
Vascular release of plasminogen activator inhibitor-1 impairs fibrinolysis during acute arterial thrombosis in mice . - pubmed
The role of plasminogen activator inhibitor-1 ( PAI-1 ) in the plasma , blood platelets , and vessel wall during acute arterial thrombus formation was investigated in gene - deficient mice . - pubmed
In comparison to thrombosis in C57BL/6J wild - type ( wt ) mice ( 113 + /- 19 x 10(6 ) arbitrary light units [ AU ] n = 15 , mean + /- SEM ) , thrombosis in PAI-1(-/- ) mice ( 40 + /- 10 x 10(6 ) AU , n = 13 ) was inhibited ( P & lt;.01 ) , indicating that PAI-1 controls fibrinolysis during thrombus formation . - pubmed
Systemic administration of murine PAI-1 into PAI-1 (-/- ) mice led to a full recovery of thrombotic response . - pubmed
The sizes of thrombi developing in wt mice , in alpha ( 2 )- AP(+/- ) and alpha ( 2 )- AP(-/- ) mice were 102 + /- 35 , 65 + /- 8.1 , and 13 + /- 6.1 x 10(6 ) AU , respectively ( n = 6 each ) ( P & lt;.05 ) , compatible with functional plasmin inhibition by alpha ( 2 )- AP . - pubmed
In contrast , thrombi in wt mice , t - PA(-/- ) and u - PA(-/- ) mice were comparable , substantiating efficient inhibition of fibrinolysis by the combined PAI-1 / alpha ( 2 )- AP action . - pubmed
Platelet depletion and reconstitution confirmed a normal thrombotic response in wt mice , reconstituted with PAI-1(-/- ) platelets , but weak thrombosis in PAI-1 (-/- ) mice reconstituted with wt platelets . - pubmed
Hence , during acute thrombosis , fibrinolysis is efficiently prevented by plasma alpha ( 2 )- AP , but also by vascular PAI-1 , locally released into the circulation after endothelial injury . - pubmed
Other novel agents being evaluated in the treatment of patients with advanced CRC include oral edrecolomab ( monoclonal antibody 17 - 1A ) and tumour vaccines . - pubmed
Quantitative correlation of cytokeratin 19 mRNA level in peripheral blood with disease stage and metastasis in breast cancer patients : potential prognostic implications . - pubmed
We determined the circulating tumor burden in BC patients by semiquantitative reverse transcription - polymerase chain reaction using carcinoembryonic antigen ( CEA ) and cytokeratin 19 ( CK19 ) mRNAs as molecular markers . - pubmed
We found CEA mRNA in 97 % of patients and 92 % of normal controls , and CK19 mRNA in 72 % of patients and 19 % of controls . - pubmed
CEA and CK19 mRNAs in normal peripheral blood were most likely derived from illegitimate transcription . - pubmed
In 10 patients , of whom 9 ( 90 % ) developed systemic metastases , the upper limit of CK19 mRNA of normal controls was exceeded . - pubmed
As compared with normal controls , significantly elevated CK19 mRNA levels in the patients appeared to originate from circulating malignant BC cells ( P<0.0001 ) . - pubmed
Of prognostic value , we report for the first time that BC patients with CK19 mRNA elevation had notably shorter ( approximately 3 - year reduction ) overall survival than patients with normal CK19 mRNA levels ( P=0.045 ) . - pubmed
Quantification of CK19 mRNA may prove useful for cancer staging , disease monitoring and prognostic assessment among BC patients . - pubmed
Hematoxylin - eosin , Masson 's trichrome , and immunohistochemical stainings for Ulex europaeus I lectin binding , CD31 , and type IV collagen were done to differentiate lymphatic and blood vessels and to demonstrate basement membranes in vascular walls and around carcinoma cell nests was observed . - pubmed
Conversion to a LFCC diet for 2 months led to normalization of glucose transport , blood pressure , plasma insulin , and VLDL - C and significant amelioration of obesity and other lipid abnormalities . - pubmed
Localization of metallothionein in urothelial carcinoma of the human urinary bladder : an immunohistochemical study including correlation with HLA - DR antigen , p53 , and proliferation indices . - pubmed
In this study MT expression was detected immunohistochemically , using a monoclonal antibody ( E9 ) against a conserved epitope of I and II isoforms , in a series of 63 cases of urothelial carcinomas of the urinary bladder . - pubmed
Correlation between MT expression and HLA - DR antigen expression , p53 , proliferation indices ( PCNA and MIBI ) as well as the various clinicopathological parameters , such as age , sex , squamous metaplasia , tumor grade , stage and recurrence were studied . - pubmed
In a semiquantitative analysis MT expression ( & gt ; 10 % of neoplastic cells ) was observed in 12.7 % , focal MT positivity in 11.1 % and almost completely lack of MT expression in 76.2 % of tumors . - pubmed
The incidence of MT expression was significantly higher ( p=0.0002 ) in cases with high pathological tumor grades . - pubmed
The data suggested that MT expression was correlated with a more aggressive behavior in urothelial bladder cancer . - pubmed
OBJECTIVE : To generate and characterize anti - idiotypic monoclonal antibody ( Ab2 ) that bears the internal image of nasopharyngeal carcinoma ( NPC ) associated antigen . - pubmed
Mice immunized with 2H4 or 5D3 coupled with keyhole limpet hemocyanin ( KLH ) , showed a positive and specific delayed - type hypersensitivity ( DTH ) reaction after stimulation by NPC cells . - pubmed
Alpha1 - acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI571 . - pubmed
At all stages of CML , AGP plasma level was significantly higher than in normal controls ( P & lt;.05 ) . - pubmed
Heparin cofactor II inhibits arterial thrombosis after endothelial injury . - pubmed
HCII has been proposed to regulate coagulation or to participate in processes such as inflammation , atherosclerosis , and wound repair . - pubmed
These observations suggest that HCII might inhibit thrombosis in the arterial circulation . - pubmed
If patients developed MTX resistance or toxicity , treatment was altered according to the level of beta human chorionic gonadotropin ( hCG ) . - pubmed
hCG values normalized in 324 ( 66.8 % ) of 485 patients with MTX alone , whereas 161 ( 33.2 % ) of 485 patients required a change in treatment , 11 because of MTX toxicity and 150 because of MTX resistance . - pubmed
CONCLUSION : Single - agent dactinomycin has activity in patients with low - risk GTD who develop MTX resistance and whose hCG is low . - pubmed
Pseudomyxoma peritonei is a disease of MUC2 - expressing goblet cells . - pubmed
Our studies revealed that pseudomyxoma peritonei is a disease of MUC2 - expressing goblet cells . - pubmed
These cells also express MUC5AC but the latter mucin is not specific for pseudomyxoma peritonei . - pubmed
MUC2 expression accounts for the voluminous deposits of extracellular mucin ( mucin : cell ratios exceeding 10:1 ) and distinguishes pseudomyxoma peritonei secondarily involving the ovary from primary ovarian mucinous tumors with peritoneal implants . - pubmed
Because mucinous tumors of the appendix similarly express MUC2 , the MUC2 expression profile also supports an appendiceal rather than ovarian origin for pseudomyxoma peritonei . - pubmed
Primary epithelial cell cultures obtained from pseudomyxoma peritonei express MUC2 whose levels can be epigenetically regulated . - pubmed
Both immunocytochemical as well as in situ hybridization studies with ancillary digital image analysis reveal that MUC2 expression in cases of pseudomyxoma peritonei is independent of the degrees of malignant transformation that are present and , in fact , reflects the constitutive levels of expression observed in normal goblet cells of the appendix . - pubmed
Extracellular mucin accumulates dramatically in pseudomyxoma peritonei because the number of MUC2 - secreting cells dramatically increase and because this MUC2 has no place to drain . - pubmed
These studies suggest that pseudomyxoma peritonei should be regarded as a disease of MUC2 - expressing goblet cells whose MUC2 expression might be susceptible to pharmacological targeting . - pubmed
After rats on gestation day 10 exposed to hyperthermia(40 degrees C ) for 0.5 , 1.0 , 2.5 and 5.0 h , red - cell C3b receptor activity(aggregate ) , red - cell immune complex , circulating immune complex , Nile blue sulfate ( NBS ) vital staining , electronic microscope and histochemical techniques were used in investigate whether the hyperthermia was disturb red - cell immune functions of pregnant rats and played some role in teratogenesis . - pubmed
The results showed that hyperthermia increased the level of red - cell C3b receptor activity , red - cell immune complex and circulating immune complex . - pubmed
[ B - type natriuretic peptide and cardiovascular disease ] . - pubmed
Is systemic disease in the coelomic epithelium associated with BRCA1 germline mutations ? - pubmed
Besides typical central effects of cannabinoids , CB1 receptor activation leads to hyperphagia , whereas its pharmacological blockade is followed by changes in energy metabolism favouring substrate oxidation . - pubmed
Angiotensin - converting enzyme 2 protects from severe acute lung failure . - pubmed
Here we report that ACE2 and the angiotensin II type 2 receptor ( AT2 ) protect mice from severe acute lung injury induced by acid aspiration or sepsis . - pubmed
However , other components of the renin - angiotensin system , including ACE , angiotensin II and the angiotensin II type 1a receptor ( AT1a ) , promote disease pathogenesis , induce lung oedemas and impair lung function . - pubmed
We show that mice deficient for Ace show markedly improved disease , and also that recombinant ACE2 can protect mice from severe acute lung injury . - pubmed
Our data identify a critical function for ACE2 in acute lung injury , pointing to a possible therapy for a syndrome affecting millions of people worldwide every year . - pubmed
ERBB2 kinase domain mutation in the lung squamous cell carcinoma . - pubmed
Recent reports revealed that the kinase domain of ERBB2 gene , a proto - oncogene , is somatically mutated in the lung adenocarcinomas , suggesting the mutated ERBB2 gene may act as an oncogene in human cancers . - pubmed
The purpose of this was to see whether the ERBB2 kinase domain is mutated in other lung cancer types besides the adenocarcinoma . - pubmed
Here , we performed mutational analysis of the ERBB2 kinase domain by polymerase chain reaction - single strand conformation polymorphism assay in 114 non - adenocarcinoma type non - small cell lung cancers ( NSCLCs ) tissue samples , including 100 squamous cell carcinomas , three adenosquamous carcinomas and 11 large cell carcinomas . - pubmed
We detected the ERBB2 kinase domain mutation in one squamous cell carcinoma ( 1.0 % ) . - pubmed
We simultaneously analyzed the somatic mutations of EGFR , K - RAS , PIK3CA and BRAF genes in the squamous cell carcinoma with the ERBB2 mutation , and found that the tumor did not harbor any EGFR or ERBB2 or K - RAS or PIK3CA or BRAF gene mutation , either . - pubmed
This study demonstrated that in addition to lung adenocarcinoma ERBB2 kinase domain mutation could occur in lung squamous cell carcinomas , and suggested that alterations of ERBB2 - mediated signaling pathway by ERBB2 mutations may occasionally contribute to the development of lung squamous cell carcinomas . - pubmed
Comparative activity of Sant7 and anti - IL-6 , IL-6R monoclonal antibodies in a murine model of B - cell lymphoma . - pubmed
Interleukin-6 ( IL-6 ) plays a central role in the pathogenesis of several autoimmune and inflammatory diseases as well as B - cell lymphoproliferative disorders . - pubmed
This work describes the effects of the recombinant or adenovirally - delivered IL-6 superantagonist Sant7 , anti - IL-6 and IL-6 receptor monoclonal antibodies in a severe murine model of human B - cell lymphoma induced in SCID mice by transplantation of an LCL-41 cell line variant ( isotype - switched IgM>IgG ) . - pubmed
Overall , the present data suggest a potential for anti - hIL-6 therapy in B - cell lymphomas . - pubmed
To the best of our knowledge , our case is the second case of extraskeletal Ewings sarcoma arising from the broad ligament but the first case that is confirmed by strong CD99 positivity and supported by fluorescence in situ hybridization . - pubmed
Mutations in the Neurofibromatosis 2 ( NF2 ) gene are associated with predisposition to vestibular schwannomas , spinal schwannomas , meningiomas , and ependymomas . - pubmed
Presently , how NF2 is expressed during embryonic development and in the tissues affected by neurofibromatosis type 2 ( NF2 ) has not been well defined . - pubmed
The NF2 promoter expression pattern during embryogenesis suggests a specific regulation of the NF2 gene during neural crest cell migration and further supports the role of merlin in cell adhesion , motility , and proliferation during development . - pubmed
This article describes recent developments in sex - related differences in opioid ( morphine ) pharmacodynamics , morphine metabolites , the nociceptin / orphanin FQ receptor system , acute opioid tolerance and opioid - induced side - effects , such as opioid - induced respiratory depression and itch , and P - glycoprotein modulation of opioid effect . - pubmed
High dose CHOP : a phase II study of initial treatment in aggressive non - Hodgkin lymphoma . - pubmed
Choriocarcinoma of testes is a very rare tumor with poor prognosis , usually presenting with high serum level of human chorionic gonadotropin ( hCG>50,000 mIU / ml ) and advanced hematogenous metastases . - pubmed
Thirteen had pure choriocarcinoma or choriocarcinoma syndrome ( normal testes by palpation and ultrasound , normal serum alpha - fetoprotein , advanced hematogenous metastases and high level hCG ) . - pubmed
Hemoglobin , red blood cell count , hematocrit , serum vitamin A , urinary iodine and prevalence of angular stomatitis were measured at baseline and at the end of the study after one year . - pubmed
Polarization of natural killer T cells towards an NKT2 subpopulation occurs after stimulation with alpha - galactosylceramide and rhG - CSF in aplastic anemia . - pubmed
In summary , our results indicate that polarization of NKT cells towards the NKT2 subpopulation occurs after co - stimulation with alpha - galactosylceramide and rhG - CSF in AA . - pubmed
Inhibition of Hsp90 activates osteoclast c - Src signaling and promotes growth of prostate carcinoma cells in bone . - pubmed
Hsp90 inhibitors are being evaluated extensively in patients with advanced cancers . - pubmed
However , the impact of Hsp90 inhibition on signaling pathways in normal tissues and the effect that this may have on the antitumor activity of these molecularly targeted drugs have not been rigorously examined . - pubmed
Breast and prostate carcinomas are among those cancers that respond to Hsp90 inhibitors in animal xenograft models and in early studies in patients . - pubmed
Because these cancers frequently metastasize to bone , it is important to determine the impact of Hsp90 inhibitors in the bone environment . - pubmed
prostate cancer xenografts , the Hsp90 inhibitor 17 - AAG stimulates the intraosseous growth of PC-3 M prostate carcinoma cells . - pubmed
This activity is mediated not by a direct effect on the tumor but by Hsp90 - dependent stimulation of osteoclast maturation . - pubmed
Both kinases are key drivers of osteoclast maturation , and three agents that block osteoclastogenesis , the Src inhibitor dasatinib , the bisphosphonate alendronate , and the osteoclast - specific apoptosis - inducer reveromycin A , markedly reduced 17 - AAG - stimulated tumor growth in bone . - pubmed
These data emphasize the importance of understanding the complex role played by Hsp90 in regulating signal transduction pathways in normal tissues as well as in cancer cells , and they demonstrate that drug - dependent modulation of the local tumor environment may profoundly affect the antitumor efficacy of Hsp90 - directed therapy . - pubmed
Hb targets : In all patients with CKD , Hb concentration should be & gt ; 11 g / dl and there is no evidence to justify total correction of anemia on a routine basis . - pubmed
Normalization of Hb levels in CKD is associated with an improvement in health - related quality of life , but without differences in mortality or the rate of loss of kidney function ( Strength of Recommendation A ) . - pubmed
Indications for iron therapy : Iron therapy is required in the large majority of patients with CKD treated with ESAs to achieve a Hb equal to or greater than 11 g / dl ( Strength of Recommendation B ) . - pubmed
The Timothy syndrome mutation of cardiac CaV1.2 ( L - type ) channels : multiple altered gating mechanisms and pharmacological restoration of inactivation . - pubmed
Timothy syndrome ( TS ) is a multiorgan dysfunction caused by a Gly to Arg substitution at position 406 ( G406R ) of the human CaV1.2 ( L - type ) channel . - pubmed
TNFalpha inhibits apoptotic cell clearance in the lung , exacerbating acute inflammation . - pubmed
Administration of TNFalpha plus apoptotic cells during LPS - induced lung injury augmented neutrophil accumulation and proinflammatory cytokine production . - pubmed
Experimental and clinical data implicate calcium and parathyroid hormone ( PTH ) in the development of prostate cancer . - pubmed
These findings support the hypothesis that serum calcium and serum PTH stimulate prostate growth in men without clinical prostate cancer and have implications for the use of PSA as a screening tool for prostate cancer . - pubmed
We compared the Access Genetics ( Minneapolis , MN ) polymerase chain reaction ( PCR ) assay ( AGPCR ) , DNA - DNA in situ hybridization ( ISH ; Ventana , Tucson , AZ ) , and HPV-16 E7 PCR amplification in consecutively accessioned oropharyngeal cancers . - pubmed
Amphiregulin - dependent mucous cell metaplasia in a model of nonallergic lung injury . - pubmed
We have previously shown that amphiregulin ( AREG ) , a ligand to the epidermal growth factor receptor ( EGFR ) , is induced during the repair / differentiation process elicited by naphthalene - induced lung injury . - pubmed
We show that AREG and epithelial EGFR expression is dispensable to pulmonary epithelial repair after naphthalene - induced lung injury , but regulates secretory cell differentiation to a mucus - producing phenotype . - pubmed
We show that the pulmonary epithelium is the source of AREG , suggesting that naphthalene - induced MCM is mediated through an autocrine signaling mechanism . - pubmed
Our data demonstrate that AREG - dependent EGFR signaling in airway epithelial cells contributes to MCM in naphthalene - induced lung injury . - pubmed
We conclude that AREG may represent a determinant of nonallergic chronic lung diseases complicated by MCM . - pubmed
Design of a hypoxia - activated prodrug inhibitor of O6 - alkylguanine - DNA alkyltransferase . - pubmed
The efficacy of agents that alkylate the O-6 position of guanine is inhibited by O ( 6 )- alkylguanine - DNA alkyltransferase ( AGT ) which removes these lesions from the tumor DNA . - pubmed
To increase differential toxicity , inhibitors must selectively deplete AGT in tumors , while sparing normal tissues where this protein serves a protective function . - pubmed
A newly synthesized prodrug of the AGT inhibitor O ( 6 )- benzylguanine ( O ( 6 )- BG ) with an alpha , alpha - dimethyl-4 - nitrobenzyloxycarbonyl moiety masking the essential 2 - amino group has demonstrated the feasibility of targeting hypoxic regions that are unique to solid tumors , for drug delivery . - pubmed
Consistent with this design , 7 demonstrates both hypoxia selective conversion by EMT6 cells of 7 to 3 and hypoxic sensitization of AGT containing DU145 cells to the cytotoxic actions of laromustine , while exhibiting improved solubility . - pubmed
Here , we identified mutations in two functionally related genes ( DDHD1 and CYP2U1 ) in individuals with autosomal - recessive forms of HSP by using either the classical positional cloning or a combination of whole - genome linkage mapping and next - generation sequencing . - pubmed
Interestingly , three subjects with CYP2U1 mutations presented with a thin corpus callosum , white - matter abnormalities , and/or calcification of the basal ganglia . - pubmed
hASCs treatment also restored normal inducible nitric oxide synthase expression in the spinal cord of CCI animals . - pubmed
Cadmium modulates H - ras expression and caspase-3 apoptotic cell death in breast cancer epithelial MCF-7 cells . - pubmed
Given the biotoxicity of cadmium and its association with carcinogenesis , the effect of that metal ion ( Cd ( II ) ) was investigated , in a concentration - dependent fashion , on cell viability , cell proliferation , caspase-3 mediated apoptosis and H - ras gene expression in human breast cancer epithelial MCF-7 cells transfected with the H - ras oncogene ( wild type and G12V mutation ) . - pubmed
Collectively , the results a ) indicate an interplay of cadmium with H - ras(wt and G12V ) , with cadmium exhibiting a significant concentration - dependent effect on the modulation of H - ras expression , cell viability and proliferation , and b ) project distinctly interwoven roles for both cadmium and H - ras in aberrant physiologies in cancer cells . - pubmed
Additionally , through chromatin - immunoprecipitation with high - throughput - sequencing and transcriptional profiling , we identify endothelin 2 ( Edn2 ) as an NFIB target aberrantly activated in NFIB - deficient hair follicle stem cells . - pubmed
Consequently , the blood calcium , calciotropic hormones , and skeleton are normal at birth despite severe vitamin D deficiency or genetic deletion of calcitriol or vitamin D receptor . - pubmed
Cytokines in bipolar disorder vs. healthy control subjects : a systematic review and meta - analysis . - pubmed
Our aim was to systematically review evidence of peripheral cytokine alterations in bipolar disorder integrating findings from various affective states . - pubmed
METHODS : We conducted a meta - analysis of studies comparing peripheral cytokine concentrations in patients with bipolar disorder with healthy control subjects . - pubmed
Overall , concentrations of soluble Interleukin ( IL )- 2 receptor ( sIL-2R ) , tumor necrosis factor - alpha ( TNF - alpha ) , soluble tumor necrosis factor receptor type 1 ( sTNFR1 ) ( p & lt ; 0.001 each ) , sIL-6R ( p = 0.01 ) and IL-4 ( p = 0.04 ) were significantly higher in bipolar patients compared with healthy controls . - pubmed
There were no significant differences between bipolar disorder patients and healthy control subjects for IL-1 , IL-2 , IL-5 , IL-6 , IL-8 , IL-10 , IL-12 , IL-1beta , IL-1 receptor antagonist ( IL-1RA ) , interferon - gamma ( IFN - gamma ) , transforming growth factor - beta1 ( TGF - beta1 ) and sTNFR2 . - pubmed
Activation of M1 mAChRs by lesatropane rescues glutamate neurotoxicity in PC12 cells via PKC - mediated phosphorylation of ERK1 / 2 . - pubmed
Lesatropane , a synthesized chiral tropane ( 3S , 6S - isomer of satropane ) , is a novel muscarinic agonist , and is being under preclinical development in China for the treatment of primary glaucoma . - pubmed
We found that lesatropane could protect PC12 cells from glutamate - induced neurotoxicity and reverse the decreased ERK1 / 2 activation caused by glutamate . - pubmed
While M1 mAChR is a therapeutic target of Alzheimer ' s disease ( AD ) , the results of this paper contribute to further information concerning the activation of M1 mAChR as a therapeutic target in AD . - pubmed
These data demonstrate for the first time that palmitic acid can stimulate IL-6 , TNF - alpha , IL-1 beta productions in HaCaT keratinocytes and cell proliferation , thereby potentially contributing to acne inflammation and pilosebaceous duct hyperkeratinization . - pubmed
Effects of green tea or green tea extract on insulin sensitivity and glycaemic control in populations at risk of type 2 diabetes mellitus : a systematic review and meta - analysis of randomised controlled trials . - pubmed
Therefore , we conducted a meta - analysis to evaluate the effect of green tea or green tea extract on insulin sensitivity and glycaemic control in populations at risk of type 2 diabetes mellitus ( T2DM ) . - pubmed
There was no statistically significant difference between green tea or green tea extract group and placebo group with regard to fasting plasma glucose [ standardised mean difference ( SMD ) 0.04 ; 95 % confidence interval ( CI ) -0.15 to 0.24 ] , fasting serum insulin ( SMD -0.09 ; 95 % CI -0.30 to 0.11 ) , 2 - h plasma glucose in the oral glucose tolerance test ( OGTT-2 h ) ( SMD -0.14 ; 95 % CI -0.63 to 0.34 ) , haemoglobin A1c ( SMD 0.10 ; 95 % CI -0.13 to 0.33 ) and homeostasis model of insulin resistance ( HOMA(IR ) ) index ( SMD -0.06 ; 95 % CI -0.35 to 0.23 ) in participants at risk of T2DM . - pubmed
CONCLUSIONS : The consumption of green tea did not decrease the levels of fasting plasma glucose , fasting serum insulin , OGTT-2 h glucose , haemoglobin A1c and HOMA(IR ) in populations at risk of T2DM . - pubmed
Larger , longer - term and high - quality RCTs are needed to further definitely determine the effect of green tea or green tea extract on insulin sensitivity and glycaemic control in populations at risk of T2DM . - pubmed
In ovo administration of high dose CORT significantly suppressed the growth rate from 3weeks of age and increased the frequency of aggressive behaviors , and the dosage was associated with elevated plasma CORT concentrations and significantly downregulated hypothalamic expression of arginine vasotocin ( AVT ) and corticotropin - releasing hormone ( CRH ) . - pubmed
At the end of the study , the immunotoxicological effects of the GM corn were evaluated through immunopathology parameters including body and organ weights , hematology and clinical chemistry parameters , histological examination , peripheral blood lymphocytes phenotype ; humoral immunity including antibody plaque - forming cell , serum immunoglobulin , cytokine and half hemolysis value ; cellular immunity such as mitogen - induced splenocyte proliferation , cytotoxic T - lymphocyte reaction , delayed - type hypersensitivity reaction ; non - specific immunity including phagocytic activities of phagocytes , natural killer cell activity . - pubmed
CONCLUSION(S ): Variability during the menstrual cycle and correlations with reproductive hormone levels support a role of cytokines in the menstrual cycle ; however , because of the limited variability for most cytokines considered , the utility of urine as a matrix for assessment of inflammation in menstrual cycle function appears limited for clinical purposes . - pubmed
Clinicopathological characteristics and chronology of p53 expression in the development of gastric cancer . - pubmed
BACKGROUND / AIMS : The present study was aimed to investigate the correlation between selected clinicopathological characteristics and p53 protein overexpression , in Indian gastric cancer patients . - pubmed
The p53 expression was analyzed in all the specimens by immunohistochemistry ( IHC ) and was correlated with the clinicopathological characteristics of the patients as well as etiological factors for gastric cancer . - pubmed
The cases were considered p53 overexpressed if more than 25 % of the tumor cells were found to be expressing this protein . - pubmed
CONCLUSIONS : Our observation showed that IHC - based detection of altered expression of p53 protein in gastric carcinomas may play an important role for diagnosing the progression of gastric carcinoma , even in the early stages . - pubmed
Urushiol Induces Apoptosis via a p53 - dependent Pathway in Human Gastric Cancer Cells . - pubmed
METHODS : The cytotoxicity of urushiols was assessed by MTT assays on the two gastric adenocarcinoma cell lines , MKN-45 ( wild type of p53 ) and MKN-28 ( mutant type of p53 ) . - pubmed
Early changes of the kinetics of monocyte trem-1 reflect final outcome in human sepsis . - pubmed
BACKGROUND : TREM-1 ( triggering receptor expressed on myeloid cells ) , a receptor expressed on neutrophils and monocytes , is upregulated in sepsis and seems to tune the inflammatory response . - pubmed
RESULTS : Although surface TREM-1 , sTREM-1 and TREM-1 gene expression did not differ between sepsis , severe sepsis and septic shock on day 1 , survivors had greater expression of surface TREM-1 on days 3 and 7 compared to non - survivors . - pubmed
A reciprocal decrease of the pro - inflammatory surface receptor TREM-1 linked with sepsis - induced immunosuppression may be part of the explanation . - pubmed
BRD4 promotes pancreatic ductal adenocarcinoma cell proliferation and enhances gemcitabine resistance . - pubmed
Our objective was to analyze the effect of BRD4 on the cell progression and chemoresistance of PDAC and the novel mechanisms involved . - pubmed
In the present study , we firstly revealed that the expression of BRD4 was significantly upregulated in PDAC cell lines , compared to that in human pancreatic duct epithelial cells . - pubmed
An in vitro assay showed that the suppression of BRD4 impaired PDAC cell viability and proliferation . - pubmed
Similarly , the tumor growth rate was also decreased in vivo after silencing of BRD4 . - pubmed
In particular , we demonstrated that BRD4 activated the Sonic hedgehog ( Shh ) signaling pathway members in a ligand - independent manner in the PDAC cells . - pubmed
Together , our results indicate the important role of BRD4 in PDAC cell proliferation and chemoresistance and suggests that BRD4 is a promising target directed against the transcriptional program of PDAC . - pubmed
Cranial CT , hematoma volume , hematoma enlargement , edema volume , serum matrix metalloproteinase-9 level were performed and compared between groups . - pubmed
Cerebral edema amount and serum MMP-9 level in the experimental group were significantly lower than control after 5 days and 14 days . - pubmed
CONCLUSIONS : Ultra - early basal ganglia intracerebral hemorrhage can remarkably reduce hematoma enlargement , cerebral edema , serum MMP-9 level , and improve the neurological function . - pubmed
Although preclinical research in murine models as well as clinical trials have provided ' proof of concept ' for infection control by pre - emptive CD8 T - cell immunotherapy , there exists no predictive model to experimentally evaluate parameters that determine antiviral efficacy of human T cells in terms of virus control in functional organs , prevention of organ disease , and host survival benefit . - pubmed
The HCMV UL83 / pp65 - derived NLV - peptide was presented by transgenic HLA - A2.1 in the context of a lethal infection of NOD / SCID / IL-2rg -/- mice with a chimeric murine CMV , mCMV - NLV . - pubmed
Nevertheless , SelT mutant mice exhibited a hyperactive behavior , suggesting that despite an apparent morphological compensation , SelT deficiency leads to cerebral malfunction in adulthood . - pubmed
Within the QTL SI regions , 44 genes were located , and runt - related transcription factor 1 , dual - specificity tyrosine -( Y )- phosphorylation regulated kinase 1A ( DYRK1A ) , and potassium inwardly - rectifying channel , subfamily J , member 15 KCNJ15 - which are reported to be related to the hematological traits and clinical features of Down syndrome - were selected as positional candidate genes . - pubmed
OBJECTIVE : To delineate the clinical features and potential mutation of the ATP7A gene in a family affected with Menkes disease . - pubmed
Our study demonstrates the effectiveness of Linc00630 oligonucleotide - based promotion of NSCLCs metastasis and proliferation , illuminating a new basis of DDX23 - Linc00630 - HDAC1 signal axis for understanding its pathogenicity , which could be further developed as a valuable therapeutic strategy . - pubmed
Identification of two novel SH3PXD2B gene mutations in Frank - Ter Haar syndrome by exome sequencing : Case report and review of the literature . - pubmed
The most common underlying genetic defect in Frank - Ter Haar syndrome appears to be due to mutations in the SH3PXD2B gene on chromosome 5q35.1 . - pubmed
RESULTS : We report the first description of a Moroccan FTHS patient with two novel compound heterozygous mutations c.806G>A ; p. Trp269 * ( maternal allele ) and c.892delC ; p. Asp299Thrfs*44 ( paternal allele ) in the SH3PXD2B gene . - pubmed
Epidemiological and genetic studies have identified elevated levels of lipoprotein ( a ) ( ( Lp ( a ) ) as a causal and independent risk factor for cardiovascular diseases ( CVD ) . - pubmed
The Lp ( a )-induced increased risk of CVD may be mediated by both its proatherogenic and prothrombotic mechanisms . - pubmed
Angiosarcoma treated successfully with anti - PD-1 therapy - a case report . - pubmed
Immunotherapy targeting either the PD-1 receptor or PD - L1 ligand has recently been shown to have activity in multiple cancers including melanoma , renal , and non - small lung cancer . - pubmed
His tumor was found to express PD - L1 and he received off - label pembrolizumab 2 mg / kg every 21 days for 13 cycles with marked shrinkage of his liver disease and no new facial lesions . - pubmed
CONCLUSIONS : Although occasional responses to immunotherapy have been reported for sarcomas , this case report demonstrates that angiosarcoma can express PD - L1 and have a sustained response to PD-1 directed therapy . - pubmed
The analysis of the current state of scientific knowledge about these pathologies shows that in the Hutchinson - Gilford progeria and Werner syndrome , the rate of brain aging is significantly lower than the rate of whole body aging , whereas in Down syndrome , the brain ages faster than other organs due to amyloid - beta accumulation and chronic oxidative stress in the brain tissue . - pubmed
Mutational analysis of ITPR1 in a Taiwanese cohort with cerebellar ataxias . - pubmed
Mutations in ITPR1 have been implicated in inherited cerebellar ataxias . - pubmed
The aim of this study was to investigate the role of ITPR1 mutations , including both large segmental deletion and single nucleotide mutations , in a Han Chinese cohort with inherited cerebellar ataxias in Taiwan . - pubmed
A novel ITPR1 mutation , c.7721T>C ( p. V2574A ) , was identified in a family with dominantly inherited cerebellar ataxia . - pubmed
CONCLUSION : ITPR1 mutation is an uncommon cause of inherited cerebellar ataxia , accounting for 0.2 % ( 1/585 ) of patients with dominantly inherited cerebellar ataxias in Taiwan . - pubmed
This study broadens the mutational spectrum of ITPR1 and also emphasizes the importance of considering ITPR1 mutations as a potential cause of inherited cerebellar ataxias . - pubmed
Combination Immunotherapy of MUC1 mRNA Nano - vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer . - pubmed
In vivo studies demonstrated that the NP - based mRNA vaccine , targeted to mannose receptors on DCs , could successfully express tumor antigen in the DCs of the lymph node ; that the NP vaccine could induce a strong , antigen - specific , in vivo cytotoxic T lymphocyte response against TNBC 4T1 cells ; and that combination immunotherapy of the vaccine and anti - CTLA-4 monoclonal antibody could significantly enhance anti - tumor immune response compared to the vaccine or monoclonal antibody alone . - pubmed
These data support both the NP as a carrier for delivery of mRNA vaccine and a potential combination immunotherapy of the NP - based mRNA vaccine and the CTLA-4 inhibitor for TNBC . - pubmed
Acetylation of alpha - tubulin at Lys-40 is a potential biomarker for cognitive deficits in various neurological disorders . - pubmed
This method has been successfully applied in a preclinical study of organophosphate neurotoxicity , and we found that chronic exposure to chlorpyrifos led to a significant and persistent inhibition of brain tubulin acetylation . - pubmed
miR372 Promotes Progression of Liver Cancer Cells by Upregulating erbB-2 through Enhancement of YB-1 . - pubmed
Our observations suggest that miR372 promotes liver cancer cell cycle progress by activating cyclin - dependent kinase 2 ( CDK2)-cyclin E - P21 / Cip1 complex through miR372 - YB-1 - beta - catenin - LEF / TCF4 - PKM2 - erbB-2 axis . - pubmed
Anaplastic lymphoma kinase - negative uterine inflammatory myofibroblastic tumor containing the ETV6 - NTRK3 fusion gene : a case report . - pubmed
Approximately 50 % of IMT patients have anaplastic lymphoma kinase gene ( ALK ) rearrangements . - pubmed
Recent studies described novel fusions involving ROS1 , platelet - derived growth factor receptor beta ( PDGFR - beta ) , and ETS translocation variant ( ETV6 ) genes in a subset of ALK - negative patients . - pubmed
This association of an ETV6 - NTRK3 fusion oncogene with an ALK - negative uterine IMT increases our understanding of this neoplasm , which may help the development of specific therapies . - pubmed
Clinical and Echocardiographic Impact of Tafazzin Variants on Dilated Cardiomyopathy Phenotype in Left Ventricular Non - Compaction Patients in Early Infancy . - pubmed
Variants in the gene encoding tafazzin ( TAZ ) may change mitochondrial function and cause dysfunction of many organs , but they also contribute to the DCM phenotype in LVNC , and the clinical and echocardiographic features of children with this phenotype are poorly understood . - pubmed
The patients with TAZ variants had a higher frequency of early onset of disease ( 92.3 % vs. 62.3 % , P=0.0182 ) , positive family history ( 73.3 % vs. 20.8 % , P=0.0001 ) , and higher LV posterior wall thickness Z - score ( 8.55 + -2.60 vs. 5.81 + -2.56 , P=0.0103 ) than those without TAZ variants , although the mortality of both groups was similar . - pubmed
CONCLUSIONS : This study provides new insight into the impact of DCM phenotype LVNC and emphasizes the clinical advantages available for LVNC patients with TAZ variants . - pubmed
Prostate - specific membrane antigen ( PSMA ) is a membrane glycoprotein that is overexpressed in prostate cancer cells . - pubmed
Many studies have reported that upregulation of SHP2 expression is closely related to human cancer , such as breast cancer , liver cancer and gastric cancer . - pubmed
Hence , SHP2 has become a promising target for cancer immunotherapy . - pubmed
TWIK - related spinal cord K + channel ( TRESK ) is a K2P channel with a particularly enriched role in sensory neurons and in vivo pain pathways . - pubmed
Autoimmune - Mediated Retinopathy in CXCR5 - Deficient Mice as the Result of Age - Related Macular Degeneration Associated Proteins Accumulation . - pubmed
Previous research has shown that CXCR5-/- mice develop retinal degeneration ( RD ) with age , a characteristic related to age macular degeneration ( AMD ) . - pubmed
RD in these mice is not well - understood , and in this study , we sought to characterize further the RD phenotype and to gain mechanistic insights into the function of CXCR5 in the retina . - pubmed
These results indicate that with age , CXCR5-/- mice develop RD characterized by microglia dysfunction , increased production of CXCL13 in the RPE progressive photoreceptor , neuronal loss , and sub - RPE deposition of cellular debris , resulting in the production of immunogenic proteins and autoimmune - mediated RD . - pubmed
Our present results underline the potential use of cagE genotyping in the risk assessment of the development of periodontal attachment loss in Swedish adolescents . - pubmed
ER - mediated anti - tumor effects of shikonin on breast cancer . - pubmed
Estrogen receptor ( ER ) is expressed in most Breast cancer ( BC ) patients . - pubmed
G protein - coupled estrogen receptor ( GPER ) , which is a membrane - bound estrogen receptor , is associated with the tumor development and progression in BC . - pubmed
This study aims to assess the effects of shikonin on the cell proliferation , cell cycle and cell apoptosis of BC and whether the effects are related to ER / GPER signaling pathway . - pubmed
CAMTA-1 Expression in 24 Cases of Hepatic Epithelioid Hemangioendothelioma in a Single Institute : Diagnostic Utility for Differential Diagnosis from Hepatic Angiosarcoma . - pubmed
EHEs are known to have the WWTR1 - CAMTA1 fusion gene , and nuclear expression of CAMTA1 by immunohistochemistry ( IHC ) has been reported in about 90 % of EHEs in multiple organs . - pubmed
Our study aimed to validate the diagnostic utility of CAMTA1 expression in EHEs , especially in the liver . - pubmed
PATIENTS AND METHODS : IHC was performed using anti - CAMTA1 antibody in 34 tumors ( 24 hepatic EHEs and 10 angiosarcomas ) . - pubmed
In CAMTA1 - negative EHEs , TFE3 IHC was performed . - pubmed
RESULTS : Of the 24 hepatic EHEs , 22 ( 91.6 % ) showed nuclear staining for CAMTA1 . - pubmed
One of two CAMTA1 - negative cases showed TFE3 positivity . - pubmed
Meanwhile , all 10 angiosarcoma cases had no CAMTA1 expression . - pubmed
CONCLUSION : CAMTA1 is a highly sensitive and specific marker for diagnosis of hepatic EHE . - pubmed
Arginase-1 - based vaccination against the tumor microenvironment : the identification of an optimal T - cell epitope . - pubmed
L - arginine depletion by regulatory cells and cancer cells expressing arginase-1 ( Arg-1 ) is a vital contributor to the immunosuppressive tumor microenvironment in patients with cancer . - pubmed
Because Arg-1 plays an important role in the immunosuppressive microenvironment in most cancers , an immune modulatory vaccination approach can readily be employed to tilt the balance away from immune suppression in these settings . - pubmed
Albumin - stabilized manganese - based nanocomposites with sensitive tumor microenvironment responsivity and their application for efficient SiRNA delivery in brain tumors . - pubmed
Background : Pretreatment albumin / alkaline phosphatase ratio ( AAPR ) has been discussed about its prognostic value in several malignancies , whereas its role in cervical cancer remains unclear . - pubmed
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy , caused by NOTCH3 mutations , is characterized by recurrent ischemic strokes and progressive cognitive decline . - pubmed
Inhibitors of Bruton ' s tyrosine kinase ( BTK ) have established therapeutic activity in patients with Waldenstrom macroglobulinemia ( WM ) . - pubmed
Zanubrutinib , a potent and selective BTK inhibitor , was evaluated in a phase 1/2 study in patients with WM who were either treatment - naive ( TN ) or had relapsed / refractory ( R / R ) disease . - pubmed
Pathological features , immunoprofile and mismatch repair protein expression status in uterine endometrioid carcinoma : focus on MELF pattern of myoinvasion . - pubmed
Our data showed a higher frequency of immunohistochemical MLH1 - PMS2 loss in MELF- pattern of invasion ( 32.67 % of MELF- cases vs 21.43 % of MELF + cases ) but a higher prevalence of MSH2 - MSH6 loss in MELF + pattern ( 7.14 % in MELF + population vs 3.96 % of MELF- population ) CONCLUSIONS : The morphological recognition of MELF pattern is more reliable than immunohistochemical and molecular signatures of EEC in predicting the risk of nodal involvement . - pubmed
Compared with severe and moderate patients , lymphocytopenia occurred in 85.71 % critically ill patients , and serum IL-2R , IL-6 , IL-8 , TNF - alpha , LDH , and cTnI were also increased in 71.42 % , 83.33 % , 57.14 % , 71.43 % , 100 % and 42.86 % in critically ill patients . - pubmed
Conclusion : We found some clinical characteristic and inflammatory cytokines could reveal the severity of COVID-19 during the outbreak phage . - pubmed
Deletions in BCP - ALL result in a TAD more FLT3 . - pubmed
A novel mutation in the RS1 gene in a Chinese family with X - linked congenital retinoschisis . - pubmed
To conclude , the present study discovered a novel XLRS mutation in a Chinese family , where the Trp122 * mutation caused a significant change in the function of the RS1 protein . - pubmed
Possible involvement of neuropeptide and neurotransmitter receptors in Adenomyosis . - pubmed
BACKGROUND : Accumulating data indicate that sensory nerve derived neuropeptides such as substance P and calcitonin gene related - protein ( CGRP ) can accelerate the progression of endometriosis via their respective receptors , so can agonists to their respective receptors receptor 1 ( NK1R ) , receptor activity modifying protein 1 ( RAMP-1 ) and calcitonin receptor - like receptor ( CRLR ) . - pubmed
In contrast , women with endometriosis appear to have depressed vagal activity , concordant with reduced expression of alpha7 nicotinic acetylcholine receptor ( alpha7nAChR ) . - pubmed
METHODS : Adenomyotic tissue samples from 30 women with adenomyosis and control endometrial tissue samples from 24 women without adenomyosis were collected and subjected to immunohistochemistry analysis of RAMP1 , CRLR , NK1R , ADRB2 and alpha7nAChR , along with their demographic and clinical information . - pubmed
RESULTS : We found that the staining levels of NK1R , CRLR , RAMP1 and ADRB2 were all significantly elevated in adenomyotic lesions as compared with control endometrium . - pubmed
The severity of dysmenorrhea correlated positively with lesional ADRB2 staining levels . - pubmed
CONCLUSIONS : Our results suggest that SP , CGRP and noradrenaline may promote , while acetylcholine may stall , the progression of adenomyosis through their respective receptors on adenomyotic lesions . - pubmed
Additionally , through the activation of the hypothalamic - pituitary - adrenal ( HPA)-sympatho - adrenal - medullary ( SAM ) axes and the lesional overexpression of ADRB2 , adenomyosis - associated dysmenorrhea and adenomyotic lesions may be mutually promotional , forming a viscous feed - forward cycle . - pubmed
Relative rates of cholesterol and bile acid synthesis were estimated in patients with cholesterol gallstones and biliary obstruction by determining the hepatic activities of 3 - hydroxy-3 - methylglutaryl - CoA reductase and cholesterol 7 alpha - hydroxylase , the respective rate - determining enzymes for cholesterol and bile acid synthesis . - pubmed
As compared with eight control studies , 3 - hydroxy-3 - methylglutaryl - CoA reductase activity was 27 % higher in 12 gallstone subjects , but 75 % lower in 5 subjects with biliary obstruction . - pubmed
Cholesterol 7 alpha - hydroxylase activity was reduced in the gallstone ( 47 % lower ) and biliary obstruction ( 78 % lower ) subjects . - pubmed
Patterns of keratin 19 expression in normal , metaplastic , condylomatous , atrophic , dysplastic , and malignant cervical squamous epithelium . - pubmed
Keratin 19 ( K-19 ) expression has been strongly correlated with dysplasia in oral epithelium . - pubmed
Expression of K-19 was evaluated by immunoperoxidase staining in formalin - fixed normal ectocervical tissue , normal endocervical tissue , cervical dysplasia , squamous metaplasia , atrophic epithelium , cervical condylomas , and invasive carcinoma to determine if a correlation of K-19 expression with dysplasia was present in the cervical epithelium . - pubmed
Uniform expression of K-19 was seen in endocervical epithelium and in the basal layer of normal ectocervical epithelium in all areas where these epithelia were present . - pubmed
Cervical dysplasia without associated condylomatous changes showed increased expression of K-19 in suprabasal epithelium , corresponding to the level of immature cells . - pubmed
There was considerable overlap in the patterns of K-19 expression in dysplastic and metaplastic epithelium . - pubmed
Thus K-19 staining pattern could not be used as a distinctive marker for dysplasia in the cervical epithelium . - pubmed
Atrophic epithelium showed a characteristic uniform but low - level expression of K-19 in suprabasal areas . - pubmed
Condylomas showed focal loss of K-19 in the basal layer , suggesting induction of premature differentiation in the basal layer by human papillomavirus infection . - pubmed
In patients with unilateral surgery , 20 of 22 patients exhibited comfortable postoperative courses , and in patients with bilateral surgery , eight of 10 patients had less conjunctival injection , chemosis , corneal staining , or lid edema on the side with the collagen shield . - pubmed
Several treatments from the latter category , namely , hypertensive , hypervolemic hemodilutional therapy and the calcium channel blocker nimodipine , have proven moderately effective and are in widespread clinical use . - pubmed
Cancer cells were equally stained with fluorescent R 1881 and mibolerone , and this fluorescence seems to be made up of both the androgen receptor and progestin - binding protein . - pubmed
Hereditary dysfibrinogenaemia ( fibrinogen Jena)--report of a family study . - pubmed
Both IgG and IgM antibody activities of lepromatous leprosy ( L - lep ) sera to 33 KD protein are heterogeneous and directed to more than 4 epitopes . - pubmed
The potential use of these McAbs in studying the pathomechanism of leprosy are currently being investigated . - pubmed
Although a causative contribution of endogenous ANF in the natriuretic response to acute hypervolemia is well established , its participation in the maintenance of salt balance during large variations in dietary Na intake is less certain . - pubmed
Although hypotension in vivo generally requires natriuretic doses of ANF , this may be due to compensatory reflexes in the intact animal. - pubmed
[ The possibilities of the use of exogenous TSH in the treatment of thyroid cancer metastases ] . - pubmed
Peripheral blood from 21 non - institutionalized children with Down ' s syndrome ( DS ) and 21 age and sex matched simultaneously studied healthy controls , was analysed for monoclonal antibody defined T cells and T cell subsets , using a fluorescence activated cell sorter , and the autologous ( AMLR ) and allogeneic mixed lymphocyte reaction ( MLR ) . - pubmed
Bilateral inferior petrosal sinus corticotropin sampling with corticotropin - releasing hormone stimulation in a pregnant patient with Cushing ' s syndrome . - pubmed
Bilateral simultaneous inferior petrosal sinus corticotropin sampling with corticotropin - releasing hormone stimulation was performed before transphenoidal pituitary adenomectomy , with successful localization of the pituitary adenoma . - pubmed
Thymidine phosphorylase expression in Kaposi sarcoma . - pubmed
AIMS : To examine the immunohistochemical distribution of thymidine phosphorylase ( TP ) in all clinicopathological subtypes of Kaposi sarcoma . - pubmed
CONCLUSIONS : The strong immunoexpression of TP suggests up - regulation of TP and a role for TP in angiogensis in Kaposi sarcoma . - pubmed
The differential staining of the various cell components of Kaposi sarcoma also suggest that TP either plays a role in the differentiation and maturation of Kaposi sarcoma or is a reflection of such changes . - pubmed
DATA SOURCES : Intervention studies cited in the Medline database from January 1976 until January 1995 , with index terms cholesterol , hypercholesterolaemia , hyperlipidaemia , thyrotrophin ( TSH ) , hypothyroidism , thyroid and human . - pubmed
Thyroid substitution therapy in patients with subclinical hypothyroidism , restoring the TSH levels to normal , decreased total cholesterol by 0.4 mmol / l ( 95 % confidence interval ( Cl ) 0.2 - 0.6 mmol / l ) independently of the initial plasma level . - pubmed
The effect of thyroid substitution therapy on HDL - cholesterol in patients with subclinical hypothyroidism was not consistent . - pubmed
Previous studies have demonstrated the presence in psoriatic lesions of ultrastructural and molecular alterations of the basement membrane and an altered polarized distribution of the integrins ; this latter alteration has also been observed in uninvolved skin . - pubmed
Immunohistochemical metallothionein expression in thymoma : correlation with histological types and cellular origin . - pubmed
Since the histopathological types of thymoma have unpredictable invasive potential , MT over - expression was investigated as a possible marker of the invasive potential of thymomas . - pubmed
We studied immunohistochemical MT expression in 27 non - invasive thymomas , 20 micro - invasive thymomas , and 23 macro - invasive thymomas with a mouse monoclonal anti - MT antibody E9 on formalin - fixed paraffin - embedded tissues . - pubmed
MT expression was significantly different among the three groups of thymomas ( P = 0.02 ) with a stronger expression in invasive thymomas ( P = 0.003 ) . - pubmed
However , MT expression was not exclusively limited to invasive thymomas . - pubmed
Analysis of MT expression according to the histological types of the thymomas revealed that eight of nine spindle cell thymomas , none of 10 small polygonal cell thymomas , four of 14 mixed thymomas , seven of 29 large polygonal cell thymomas , and seven of eight squamoid thymomas significantly expressed MT . - pubmed
There was a statistically significant difference in MT expression among different histological types of thymomas ( P = 0.000 ) . - pubmed
Since spindle cell thymoma was usually non - invasive and squamoid thymoma was more aggressive , MT expression does not correlate with the invasive potential of different histological types of thymomas . - pubmed
But because medullary epithelial cells of the thymus were positive for MT , our results suggest that both spindle cell thymoma and squamoid thymoma might derive from the medullary compartment of the thymus . - pubmed
The functional activity of each LCR was measured by cloning it into a luciferase expression vector , followed by transfection into both normal oral keratinocytes and oral cancer cells . - pubmed
Near nerve local insulin prevents conduction slowing in experimental diabetes . - pubmed
We tested the hypothesis that insulin itself influences conduction of myelinated fibers independent of hyperglycemia in experimental diabetes . - pubmed
Low dose intermittent ( 0.2 units thrice weekly ) Toronto ( regular ) insulin was injected at the sciatic notch and knee near the left sciatic nerve of rats rendered diabetic with citrate buffered streptozotocin or nondiabetic rats given citrate only . - pubmed
The diabetic rats developed hyperglycemia , elevated glycosylated hemoglobin levels and had slowing of right ( saline treated ) sciatic tibial motor and caudal sensory conduction velocity . - pubmed
In nondiabetic rats , conduction velocities were slightly higher on the insulin treated side , but the influence of insulin was less robust than in diabetics . - pubmed
The insulin treated sural branches of the sciatic nerves in diabetics had a higher percentage of small ( & lt ; or = 9.0 microm diameter ) myelinated fibers than the saline treated nerves . - pubmed
Local insulin has a trophic influence on myelinated fibers that is prominent in diabetic nerves and is independent of hyperglycemia . - pubmed
Cilostamide had no effect on the cAMP content stimulated by PTH or AVP in PCTs and MCDs . - pubmed
These results indicate that PDE activities were unevenly distributed along the rat nephron and cAMP - PDE was composed of at least three isoforms , namely type I , III and IV in PCTs and MCDs . - pubmed
Among these , type - IV PDE was responsible for hydrolysis of cAMP in PCTs , and type - I and IV PDE were responsible for that in MCDs . - pubmed
Polymorphism in the promoter region of the alpha 2A adrenergic receptor gene and mood disorders . - pubmed
Alpha 2 adrenergic receptors are thought to play a crucial role in the etiology or treatment of mood disorders . - pubmed
Polymorphism(s ) in the promoter region of the alpha 2 receptor may affect the gene expression and be associated with mood disorders . - pubmed
We studied the previously reported polymorphisms of the alpha 2A receptor gene at position-1291 in 114 healthy controls and 103 mood disorder patients . - pubmed
Our results suggest there is no association between this polymorphism in the promoter region of the alpha 2A receptor gene and mood disorders . - pubmed
A number of proto - oncogenes ( Cyclin D and PTHLH ) as well as putative tumor suppressor genes are localized on 12p ; however , their role in pathogenesis and prognosis of testicular germ cell tumors has not been defined yet . - pubmed
The startle disease mutation Q266H , in the second transmembrane domain of the human glycine receptor , impairs channel gating . - pubmed
Hyperekplexia ( startle disease ) results from mutations in the glycine receptor chloride channel that disrupt inhibitory synaptic transmission . - pubmed
Both vWF antigen and platelet aggregation decreased 2 weeks after the onset of myocardial infarction . - pubmed
CONCLUSIONS : Shear - induced platelet aggregation is enhanced in plasma in the presence of acute myocardial infarction , apparently as a result of increased vWF concentration . - pubmed
We measured the serum levels of IL-7 before and after bone marrow transplant ( BMT ) in 32 children undergoing BMT for genetic diseases ( severe combined immune deficiency ( SCID ) and thalassemia ) , aplastic anemia , and acute lymphoblastic and non - lymphoblastic leukemia ( ALL and ANLL ) . - pubmed
Prior to BMT , the highest IL-7 levels were observed in patients with SCID and ALL , i.e. - pubmed
Patients with thalassemia and ANLL had normal levels of IL-7 . - pubmed
Over the 8 weeks following BMT , the IL-7 levels of patients with SCID and ALL fell as the absolute lymphocyte count ( ALC ) increased . - pubmed
No detectable change in IL-7 levels was observed in the patients with thalassemia and ANLL . - pubmed
Levels of IL-7 were highest in the young infants with SCID compared to the age - matched controls . - pubmed
Together , the data demonstrate that serum levels of IL-7 in lymphopenic patients are inversely related to patient age and the absolute lymphocyte count ( ALC ) . - pubmed
BACKGROUND : We have previously developed a mu - capture - based radioimmunoassay ( RIA ) for detecting virus - specific IgM for the diagnosis of poliomyelitis . - pubmed
CONCLUSION : Cross - reactive epitopes between poliovirus serotypes and between polioviruses and other enteroviruses may compromise the use of an assay for virus - specific IgM for poliovirus diagnosis . - pubmed
In this review we discuss the role of two of these neuropeptides , somatostatin and substance P , with regard to their receptor expression in the human immune system and their role in the diagnosis and treatment of immune - mediated diseases . - pubmed
Alosetron , a 5 - HT3 receptor antagonist , delays colonic transit in patients with irritable bowel syndrome and healthy volunteers . - pubmed
BACKGROUND : Alosetron is a potent and selective 5 - HT3 receptor antagonist , which has been shown to be beneficial in the treatment of female patients with non - constipated irritable bowel syndrome . - pubmed
Haplotype analysis suggests that this FSGS gene is located in a 19 - cM region flanked by D1S416 and D1S413 , of which 6 cM overlaps with SRN1 , suggesting that these distinct clinical subsets of kidney disease may be allelic . - pubmed
Phase I pilot trial of the bispecific antibody MDXH210 ( anti - Fc gamma RI X anti - HER-2 / neu ) in patients whose prostate cancer overexpresses HER-2 / neu . - pubmed
The goal of this study was to evaluate , in patients with prostate cancer , the toxicity profile and biologic activity of the bispecific antibody MDXH210 , which has specificity for the non - ligand - binding site of the high - affinity immunoglobulin G receptor ( Fc gamma RI ) and the extracellular domain of the HER-2 / neu proto - oncogene product . - pubmed
Patients with prostate cancer that expressed HER-2 / neu were entered into a phase I dose - escalation trial of MDXH210 . - pubmed
MDXH210 can be given safely to patients with HER-2 / neu - positive prostate cancer in doses of at least 8 mg / m2 . - pubmed
Hypertrophic pulmonary osteoarthropathy associated with non - small cell lung cancer demonstrated growth hormone - releasing hormone by immunohistochemical analysis . - pubmed
Hypertrophic pulmonary osteoarthropathy ( HPO ) associated with non - small cell lung cancer in a 58 - year - old man was accompanied by an elevated serum level of growth hormone ( GH ) . - pubmed
HPO rapidly disappeared after resection of the primary tumor and the elevation of serum GH was resolved . - pubmed
Immunohistochemically the tumor contained growth hormone - releasing hormone ( GHRH ) but not GH . - pubmed
These findings suggest that the high serum GH level due to ectopic GHRH production in the tumor , was a contributing factor in HPO . - pubmed
This is the second reported case of non - small cell lung cancer which was immunohistochemically positive for GHRH associated with HPO . - pubmed
We now show that DNA damage is able to induce senescence in tumor cells expressing wild - type p53 . - pubmed
Pemphigus vulgaris in Jewish patients is associated with HLA - A region genes : mapping by microsatellite markers . - pubmed
Pemphigus vulgaris ( PV ) is the most severe autoimmune blistering disorder of the skin that is mediated by circulating autoantibodies against desmoglein 3 ( Dsg3 ) . - pubmed
It has been reported that in Jews the associated haplotype in PV is human leukocyte antigen ( HLA ) B38 , DRB1 * 0402 , DQB1 * 0302 . - pubmed
Dsg3 - specific T - cell responses were detected in PV patients but also in healthy individuals who were either carriers of the PV - associated DRB1 * 0402 allele or alleles that share similar or identical peptide binding motifs to DRB1 * 0402 . - pubmed
However , four probes , D6S265 , C_527 , D6S510 , and MOGC , which are all mapped to the region of HLA - A , were highly associated with PV . - pubmed
[ Correction in vitro of A and B hemophilia by various dilutions of normal blood : modifications of clotting time and of prothrombin consumption ] . - pubmed
Using a squamous carcinoma cell line we show that endogenous accumulation of GM3 disrupts the ligand - independent association of the integrin beta1 subunit with EGFR and results in inhibition of cell proliferation . - pubmed
Tissue and plasma expression of the angiogenic peptide adrenomedullin in breast cancer . - pubmed
Adrenomedullin ( ADM ) is an angiogenic factor that has also been shown to be a mitogen and a hypoxia survival factor for tumour cells . - pubmed
These properties point to ADM as a potential promoter of human malignancies , but little data are available concerning the expression of ADM in human breast cancer . - pubmed
In the present work , we have examined ADM peptide expression in a series of malignant breast tumours by immunohistochemistry using a newly developed anti - ADM monoclonal antibody . - pubmed
ADM - peptide expression in breast tumours was significantly correlated with axillary lymph node metastasis ( P=0.030 ) . - pubmed
Analysis of ADM plasma concentrations showed no significant difference between the circulating ADM levels of breast cancer patients and healthy controls . - pubmed
However , a significant positive correlation was found between tumour size and plasma ADM levels ( r=0.641 , P=0.017 ) . - pubmed
Moreover , ADM levels in breast cancer patients correlated with the presence of lymph node metastasis ( P=0.002 ) . - pubmed
In conclusion , we have shown for the first time that ADM peptide is widely expressed in breast cancer and that the degree of expression is associated with lymph node metastasis . - pubmed
ADM peptide in plasma of breast cancer patients reflects the size of the primary tumour , but is unlikely to be a useful tumour marker for the detection of breast cancer . - pubmed
Temporal relationship of muscle weakness and pain reduction in subjects treated with botulinum toxin A. - pubmed
We show here that , in the Pitx3 - deficient aphakia ( ak ) mouse mutant , the mesDA system is malformed . - pubmed
Factor VIII levels and the risk of pre - eclampsia , HELLP syndrome , pregnancy related hypertension and severe intrauterine growth retardation . - pubmed
The aim of this study was to determine whether elevated factor VIII levels are associated with uteroplacental insufficiency , in particular pre - eclampsia , HELLP syndrome or pregnancy - induced hypertension and intrauterine growth retardation . - pubmed
METHODS : Plasma samples of 75 women with a history of pregnancy complicated by pre - eclampsia , HELLP syndrome , pregnancy induced hypertension or intrauterine growth restriction were tested for factor VIII : C ( FVIII : C ) levels at a minimum of 10 weeks post - partum . - pubmed
In a logistic regression model , after adjusting for age and blood group , no effect of factor VIII : C levels on the risk of pregnancy complications was observed , with the exception of IUGR with ( OR 2.9 , CI 1.0 - 8.7 ) or without hypertension ( OR 2.0 , CI 0.7 - 6.4 ) . - pubmed
While no such effect could be shown a causal relationship between elevated levels of factor VIII and conditions of uteroplacental insufficiency such as pre - eclampsia , HELLP syndrome , pregnancy - induced hypertension and IUGR is not very likely . - pubmed
Protein kinase C - dependent regulation of NAG-1 / placental bone morphogenic protein / MIC-1 expression in LNCaP prostate carcinoma cells . - pubmed
NAG-1 ( nonsteroidal anti - inflammatory drug - activated gene ) , a member of the transforming growth factor beta superfamily , is involved in cellular processes such as inflammation , apoptosis / survival , and tumorigenesis and is regulated by p53 , Sp1 , and Egr-1 . - pubmed
In the current study , the regulation of NAG-1 expression in LNCaP human prostate carcinoma cells by 12 - O - tetradecanoylphorbol-13 - acetate ( TPA ) was examined . - pubmed
Deletion of the second orf did not abrogate hemolysis , indicating that the first ORF encoded the hemolysin . - pubmed
Mucosal immunization of sheep with a Maedi - Visna virus ( MVV ) env DNA vaccine protects against early MVV productive infection . - pubmed
Gene gun mucosal DNA immunization of sheep with a plasmid expressing the env gene of Maedi - Visna virus ( MVV ) was used to examine the protection against MVV infection in sheep from a naturally infected flock . - pubmed
BACKGROUND : The importance of achieving a low - density lipoprotein cholesterol ( LDL - C ) level less than 100 mg / dL in patients with coronary artery disease ( CAD ) or cerebrovascular disease ( CVD ) is well established . - pubmed
Relationship between renal function and plasma brain natriuretic peptide in patients with heart failure . - pubmed
OBJECTIVES : This study sought to evaluate the relationship between brain natriuretic peptide ( BNP ) , renal function , and the severity of congestive heart failure ( CHF ) . - pubmed
BACKGROUND : Both BNP and renal function are prognostic predictors in CHF patients . - pubmed
METHODS : We measured the plasma BNP level in the aortic root and coronary sinus in 366 consecutive patients with CHF . - pubmed
CONCLUSIONS : These findings suggest that decreased clearance from the kidney contributes to the elevated BNP in CHF patients with renal dysfunction , especially in patients with an eGFR & lt;60 ml / min . - pubmed
The methodology is illustrated through an example based on a study about the joint effects of XRCC1 polymorphisms and smoking on bladder cancer . - pubmed
Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries . - pubmed
AIM : To investigate the expression of two intestinal markers , galectin 4 and meprin alpha , in mucinous carcinomas of the ovary and gastrointestinal tract . - pubmed
METHODS : Using immunohistochemical analysis , the expression of galectin 4 and meprin alpha was investigated in 10 MOCs and in 38 mucinous adenocarcinomas of colon , pancreas , stomach and appendix , the most common sites of origin of ovarian metastases . - pubmed
RESULTS : Total cytoplasmic galectin 4 expression was relatively consistent between the different carcinomas . - pubmed
Membranous meprin alpha expression was significantly lower in MOCs compared with gastrointestinal carcinomas . - pubmed
Moreover , meprin alpha expression showed greater discrimination between the ovarian and gastrointestinal carcinomas than the cytokeratins CK7 and CK20 , the current standard immunohistochemical markers used to determine the tissue origin of mucinous carcinomas involving the ovaries . - pubmed
CONCLUSIONS : Meprin alpha is a useful additional marker in differentiating primary from secondary mucinous adenocarcinomas of the ovary . - pubmed
OBJECTIVE : We examined factors associated with screening for albuminuria and initiation of ACE inhibitor or angiotensin receptor blocker ( ARB ) treatment in diabetic patients . - pubmed
Patients & gt ; or = 65 years of age , those with higher HbA ( 1c ) , those with cardiovascular disease ( CVD ) , and those without hyperlipidemia were less likely to be screened . - pubmed
Initiation of therapy was associated with positive screening test results , BMI & gt ; or = 25 kg / m(2 ) , treatment with insulin or oral antidiabetic agents , peripheral neuropathy , systolic blood pressure & gt ; or = 140 mmHg , and CVD . - pubmed
pneumophila cytochrome c maturation locus in low - iron growth , intracellular infection , and virulence . - pubmed
STUDY DESIGN : Retrospective observational analysis of claims - based data of health plan members with CAD receiving 1 or more prescriptions per year of any of the following classes of medications used for secondary prevention of CAD : lipid - lowering agents , angiotensin - converting enzyme ( ACE ) inhibitors , or angiotensin receptor blockers ( ARBs ) and beta - blockers . - pubmed
Expression of cyclooxygenase-2 in osteosarcoma of bone . - pubmed
Several studies indicate that cyclooxygenase-2 ( COX-2 ) is overexpressed in human malignancies , where it produces high levels of prostaglandins and contributes to tumor growth . - pubmed
In this study we have analyzed the expression of COX-2 in a series of 48 skeletal osteosarcomas of different subtypes by immunohistochemistry . - pubmed
In addition , we examined the effects of the specific COX-2 inhibitor Celecoxib on the growth of the human osteosarcoma cell line SaOS-2 . - pubmed
Immunoreactivity for COX-2 was observed in 39 out of 48 tumors ( 81.2 % ) , 30 ( 76.9 % ) of which showed a moderate or diffuse immunostaining . - pubmed
Considering the group of 42 primary osteosarcomas , COX-2 immunoreactivity was significantly higher in high grade osteosarcomas , where moderate or diffuse expression was detected in 23 out of 32 cases ( 71.8 % ) , than in low grade osteosarcomas , where moderate or diffuse expression was detected in 2 out of 10 cases ( 20 % ) ( P = 0.008 , Fisher exact test ) . - pubmed
In SaOS-2 osteosarcoma cells , which express COX-2 , treatment with Celecoxib determined inhibition of cell proliferation and induction of apoptosis . - pubmed
These results indicate that COX-2 is expressed at high levels in high grade osteosarcomas and support the use of COX-2 inhibitors to improve both the tumor response to chemotherapy and the outcome of osteosarcoma patients . - pubmed
To investigate potential adaptive immune mechanisms in IPF , we compared phenotypes and effector functions of peripheral CD4 T cells , autoantibody production , and proliferative responses of pulmonary hilar lymph node CD4 T cells to autologous lung extracts from afflicted patients and normals . - pubmed
Our results show that greater proportions of peripheral CD4 T lymphocytes in IPF subjects expressed MHC class II and CD154 ( CD40L ) , and they more frequently elaborated TGF - beta1 , IL-10 , and TNF - alpha . - pubmed
Abnormal CD4 T cell clonal expansions were found in all IPF patients , and 82 % of these subjects also had IgG autoantibodies against cellular Ags . - pubmed
OBJECTIVE AND DESIGN : Cytokine - mediated immunoresponses are consequences of isolated traumatic brain injury ( TBI ) and muskuloskeletal trauma but little is known when both impacts occur simulanteously in combined neurotrauma ( CNT ) , i. e. TBI + muskuloskeletal trauma ( bone fracture ) . - pubmed
MATERIALS AND METHODS : A " two - hit"-experimental model of CNT ( TBI + tibia fracture ) was used to investigate circulating cytokine interleukin-1 - beta , - 6 , - 10 and sTNF - R1 concentrations following peripheral bone fracture only , TBI only and CNT . - pubmed
Blood samples were drawn at 30 min , 6 h , 24 h , 48 h , and 7 days following trauma and circulating cytokine concentrations were determined via immunoassay . - pubmed
RESULTS : Circulating cytokines were increased after trauma ( p & lt;0.001 vs. controls ) , but peaked at different time points . - pubmed
sTNF R1 peaked first at 30 min , followed by IL-6 at 6 h after trauma . - pubmed
IL-10 levels were highest at 24 h , and those for IL-1beta at 48 h after trauma . - pubmed
CONCLUSION : Circulating cytokine IL-1 - beta , - 6 , - 10 and sTNF - R1 concentrations are increased after trauma ( TBI , fracture and CNT ) but peak at different time points . - pubmed
Pronounced IL-6 and IL-10 responses after CNT may contribute to the increased susceptibility for complications in CNT versus monotrauma . - pubmed
Thiopurine - methyltransferase and inosine triphosphate pyrophosphatase polymorphism in a liver transplant recipient developing nodular regenerative hyperplasia on low - dose azathioprine . - pubmed
Increased morbidity and mortality is rarely observed in patients with a hemoglobin concentration & gt;7 g / dL , and the acute hemoglobin threshold for cardiovascular collapse may be as low as 3 g / dL to 5 g / dL. - pubmed
As 17beta - HSD1 is often overexpressed in mammary tumors and endometriosis , the selective inhibition of this enzyme is discussed as a promising approach for the treatment of estrogen - dependent diseases . - pubmed
Mucosal immunization with purified ClpP could elicit protective efficacy against pneumococcal pneumonia and sepsis in mice . - pubmed
Caseinolytic protease ( ClpP ) has been found to be highly conserved among different strains of Streptococcus pneumoniae and intraperitoneal immunization with ClpP could elicit protection against invasive pneumococcal infections . - pubmed
In this study , mucosal immunization with ClpP antigen induced both systemic and mucosal antibodies , and in this way reduced lung colonization in an invasive pneumococcal pneumonia model and also protected mice against death in an intraperitoneal - sepsis model . - pubmed
CONCLUSIONS : These data show that dual gene therapy with ER / GR might be a useful tool for understanding the role of steroid hormones in the storage of traumatic memories . - pubmed
Exendin-4 improves glycemic control , ameliorates brain and pancreatic pathologies , and extends survival in a mouse model of Huntington ' s disease . - pubmed
Huntington ' s disease is a neurodegenerative disorder caused by a polyglutamine expansion within the huntingtin protein . - pubmed
Similarly to Huntington ' s disease patients , mice expressing the mutated human huntingtin protein also exhibit neurodegenerative changes , motor dysfunction , perturbed energy metabolism , and elevated blood glucose levels . - pubmed
RESEARCH DESIGN AND METHODS : Huntington ' s disease mice were treated with an FDA - approved antidiabetic glucagon - like peptide 1 receptor agonist , exendin-4 ( Ex-4 ) , to test whether euglycemia could be achieved , whether pancreatic dysfunction could be alleviated , and whether the mice showed any neurological benefit . - pubmed
RESULTS : Ex-4 treatment ameliorated abnormalities in peripheral glucose regulation and suppressed cellular pathology in both brain and pancreas in a mouse model of Huntington ' s disease . - pubmed
CONCLUSIONS : Targeting both peripheral and neuronal deficits , Ex-4 is an attractive agent for therapeutic intervention in Huntington ' s disease patients suffering from diabetes . - pubmed
Subjects who were positive for both IgA - AGA and IgA - EMA were classified as having CD . - pubmed
Of the 192 patients evaluated , only one ( 0.5 % ) was found to have positive for both IgA - AGA and IgA EMA tests and accepted as having CD . - pubmed
Further , we examined changes in phospho protein kinase A ( pPKA ) levels following an immediate and a delayed onset of reaching training in rats with cervical SCI . - pubmed
Strikingly , only delayed reaching training restored cortical PKA levels that had dropped significantly over 2 weeks post - injury . - pubmed
The further distribution of the MEMP patients ' group was the following--5 patients had MEMP with lactic acidosis , 5 had Leigh ' s disease ( subacute necrotizing encephalopathy ) , from which 1 had cytochrome - c - oxidase deficiency ( COX ) . - pubmed
Among them the ornithine transcarbamylase ( OTC ) heterozygous female patient with left - sided hemiparesis caused by hyperammonemic stroke at 10 month - age , showed right sided temporoparietal , occipital and left frontal hypoperfusion , nearly 6 years after the cerebral vascular attack . - pubmed
Endothelial dysfunction is intricately related to insulin resistance through the parallel stimulatory effects of insulin on glucose disposal in metabolic tissues and NO production in the endothelium . - pubmed
Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta . - pubmed
Interleukin-1beta ( IL-1beta ) is a pleiotropic cytokine promoting inflammation , angiogenesis , and tissue remodeling as well as regulation of immune responses . - pubmed
Although IL-1beta contributes to growth and metastatic spread in experimental and human cancers , the molecular mechanisms regulating the conversion of the inactive IL-1beta precursor to a secreted and active cytokine remains unclear . - pubmed
Late stage human melanoma cells spontaneously secrete active IL-1beta via constitutive activation of the NALP3 inflammasome and IL-1 receptor signaling , exhibiting a feature of autoinflammatory diseases . - pubmed
In contrast , NALP3 functionality in intermediate stage melanoma cells requires activation of the IL-1 receptor to secrete active IL-1beta ; cells from an early stage of melanoma require stimulation of the IL-1 receptor plus the co - stimulant muramyl dipeptide . - pubmed
These findings implicate IL-1 - mediated autoinflammation as contributing to the development and progression of human melanoma and suggest that inhibiting the inflammasome pathway or reducing IL-1 activity can be a therapeutic option for melanoma patients . - pubmed
Plasma N - terminal fragment of the prohormone B - type natriuretic peptide concentrations in relation to time to treatment and Thrombolysis in Myocardial Infarction ( TIMI ) flow : a substudy of the Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention ( ASSENT IV - PCI ) trial . - pubmed
BACKGROUND : We investigated the prognostic significance of plasma N - terminal fragment of the prohormone B - type natriuretic peptide ( Nt - proBNP ) concentrations in addition to time to reperfusion and Thrombolysis in Myocardial Infarction ( TIMI ) flow before and after coronary intervention in patients with ST elevation myocardial infarction ( STEMI ) from the database of the Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention ( ASSENT IV - PCI ) trial . - pubmed
METHODS : Plasma Nt - proBNP was available in 1,037 patients with STEMI . - pubmed
Discovery of 7 -( 4 -( 3 - ethynylphenylamino )- 7 - methoxyquinazolin-6 - yloxy )- N - hydroxyheptanamide ( CUDc-101 ) as a potent multi - acting HDAC , EGFR , and HER2 inhibitor for the treatment of cancer . - pubmed
These results suggest that a single compound that simultaneously inhibits HDAC , EGFR , and HER2 may offer greater therapeutic benefits in cancer over single - acting agents through the interference with multiple pathways and potential synergy among HDAC and EGFR / HER2 inhibitors . - pubmed
Protease - activated receptor-1 ( PAR1 ) is a G protein - coupled receptor that plays critical roles in cancer , angiogenesis , inflammation , and thrombosis . - pubmed
Unexpectedly , BicD1 was also found to be a potent suppressor of PAR1 - driven proliferation of breast carcinoma cells . - pubmed
The aim of this study was to analyze , by FISH for 5q31 ( EGR1 ) , a series of 28 MDS and AML cases with monosomy 5 detected by G - banding . - pubmed
Prognostic relevance of KIT and PDGFRA mutations in gastrointestinal stromal tumors . - pubmed
Here , we aimed to assess whether KIT and PDGFRA mutations have survival impact in gastrointestinal stromal tumors ( GIST ) . - pubmed
PATIENTS AND METHODS : Fifty - five Brazilian patients with completely resected GIST were examined for KIT and PDGFRA mutations . - pubmed
The 5 - year DFS rate was lower in patients with tumors having in - frame deletions or concomitant in - frame deletions and insertions affecting codons 557 - 558 than in patients with tumors having other exon 11 KIT mutations ( p=0.023 ) . - pubmed
CONCLUSION : Our findings indicate that a specific KIT mutation may be associated with unfavorable behavior in GIST . - pubmed
Uncontrolled studies suggest that prostacyclin analogues and phosphodiesterase type-5 inhibitors may have benefits in advanced pulmonary vascular disease . - pubmed
Accumulative in vivo evidence shows that increased bone resorption occurs at an early stage in the development of osteoarthritis and that blocking bone - resorbing cytokines prevents cartilage damage , confirming the role of bone factors in the crosstalk of both tissues . - pubmed
This review will summarize what is known about the contribution of bone cytokines to the physiological remodeling of cartilage and in the pathophysiology of osteoarthritis . - pubmed
[ Effect of vitamin C on the condition of NO - synthase system in experimental stomach ulcer ] . - pubmed
We investigated the effect of Vitamin C ( Vit C ) on the changes of activity of the enzymes of NO - synthase system , nitric oxide content , lipoperoxidation processes , activity of SOD and catalase in gastric mucosa ( GM ) , and concentrations of L - arginine , Vit C and Vit E in the blood of rats under conditions of experimental ulcer of the stomach caused by adrenaline injection . - pubmed
Survivin knockdown could induce cancer cell apoptosis and inhibit tumor - angiogenesis . - pubmed
ARID1A expression loss in gastric cancer : pathway - dependent roles with and without Epstein - Barr virus infection and microsatellite instability . - pubmed
The AT - rich interactive domain 1A gene ( ARID1A ) , which encodes one of the subunits in the Switch / Sucrose Nonfermentable chromatin remodeling complex , carries mutations and is responsible for loss of protein expression in gastric carcinoma , particularly with Epstein - Barr virus ( EBV ) infection and a microsatellite instability - high phenotype . - pubmed
We used immunohistochemistry to investigate the significance of ARID1A loss in 857 gastric carcinoma cases , including 67 EBV(+ ) and 136 MLH1 - lost gastric carcinomas ( corresponding to a microsatellite instability - high phenotype ) . - pubmed
Loss of ARID1A expression was significantly more frequent in EBV(+ ) ( 23/67 ; 34 % ) and MLH1 - lost ( 40/136 ; 29 % ) gastric carcinomas than in EBV(-)MLH1 - preserved ( 32/657 ; 5 % ) gastric carcinomas ( P & lt ; 0.01 ) . - pubmed
Loss of ARID1A correlated with larger tumor size , advanced invasion depth , lymph node metastasis , and poor prognosis in EBV(-)MLH1 - preserved gastric carcinoma . - pubmed
A correlation was found only with tumor size and diffuse - type histology in MLH1 - lost gastric carcinoma , but no correlation was observed in EBV(+ ) gastric carcinoma . - pubmed
Loss of ARID1A expression in EBV(+ ) gastric carcinoma was highly frequent in the early stage of gastric carcinoma , although EBV infection did not cause downregulation of ARID1A : EBV - positive nasopharyngeal carcinomas ( n = 8) and lymphomas ( n = 15 ) failed to show loss of ARID1A , and EBV infection did not cause loss of ARID1A in gastric carcinoma cell lines . - pubmed
Taken together , loss of ARID1A may be an early change in carcinogenesis and may precede EBV infection in gastric epithelial cells , while loss of ARID1A promotes cancer progression in gastric cancer cells without EBV infection or loss of MLH1 expression . - pubmed
Loss of ARID1A has different and pathway - dependent roles in gastric carcinoma . - pubmed
Blood lead , delta - aminolevulinic acid dehydratase ( delta - ALAD ) and zinc protoporphyrin ( ZPP ) concentrations are widely used as biomarkers for lead toxicity The present study was designed to determine the impact of chronic lead exposure on selected biological markers . - pubmed
[ Monoclonal antibodies targeting IL-17A or its receptor in psoriasis : a new therapeutic approach ? ] - pubmed
alpha - Lipoic acid ameliorates mitochondrial impairment and reverses apoptosis in FABP3 - overexpressing embryonic cancer cells . - pubmed
We have previously shown FABP3 was more highly expressed in myocardium with ventricular septal defects than in normal myocardium and furthermore , that overexpression of FABP3 causes mitochondrial dysfunction and induces apoptosis in the P19 mouse teratocarcinoma cell line ( P19 ) , which is a suitable model for the investigation of cardiac differentiation at the molecular and functional levels . - pubmed
In this study , we established an FABP3 - overexpressing P19 cell line for the investigation of the impact of alpha - LA on mitochondrial impairment and apoptosis in these cells . - pubmed
Collectively , our results indicate that abnormalities in FABP3 expression contribute to mitochondrial dysfunction and apoptosis , and that alpha - LA represents a suitable candidate for development as a treatment for apoptosis - related congenital cardiac malformations . - pubmed
OBJECTIVE : To prospectively study the relation between TSH and risk of hip and forearm fractures . - pubmed
METHODS : In a substudy of the second survey of the Nord Trondelag Health Study , Norway ( HUNT2 , 1995 - 97 ) , linked with a hospital - based fracture registry , we investigated the relation between baseline TSH and risk of hip and / or forearm fractures . - pubmed
Overall , there was no relation between baseline TSH and fracture risk . - pubmed
However , there was weak evidence that women with TSH & lt;0.5 and & gt;3.5 mU / l had a slightly increased risk of hip fractures ( hazard ratio ( HR ) 1.30 , 95 % CI 0.97 - 1.94 and HR 1.19 , 95 % CI 0.93 - 1.52 ) compared with the reference group with TSH of 1.5 - 2.4 mU / l. Supplementary analyses showed higher hip fracture risk in women with TSH & gt;4.0 mU / l and negative thyroid peroxidase antibodies ( TPOAb ) compared with the reference group ( HR 1.75 , 95 % CI 1.24 - 2.46 ) . - pubmed
CONCLUSION : We found no statistically significant relation between baseline TSH and subsequent fracture risk , but the data suggest a weak positive association with hip fracture risk among women with both low and high TSH . - pubmed
Two distinct approaches have emerged to try to extend survival in patients with metastatic melanoma : immunomodulation with anti - CTLA4 monoclonal antibodies , and targeted therapy with BRAF inhibitors or MEK inhibitors for BRAF - mutated melanoma . - pubmed
Anti - PD1 and anti - PDL1 antibodies have emerged as breakthrough drugs for melanoma that have high response rates and long durability . - pubmed
Biomarkers that have predictive value remain elusive in melanoma , although emerging data for adjuvant therapy indicate that interferon sensitivity is associated with ulceration of the primary melanoma . - pubmed
Finally , we show that administration of IL-4 to immunodeficient mice to regulate inflammation by induction of type 2 responses also restores parasite development . - pubmed
Calprotectin ( S100A8 / A9 ) , S100A12 , and EDTA - resistant S100A12 complexes ( ERAC ) in primary Sjogren ' s syndrome . - pubmed
Injury - mediated increased K (+ ) efflux through Kv2.1 channels promotes neuronal apoptosis , contributing to widespread neuronal loss in neurodegenerative disorders such as Alzheimer ' s disease and stroke . - pubmed
Kv1 and Kv7 channel dysfunction leads to neuronal hyperexcitability that critically contributes to the pathophysiology of human clinical disorders such as episodic ataxia and epilepsy . - pubmed
This review summarizes the neurotoxic , neuroprotective , and neuroregulatory roles of Kv channels and highlights the consequences of Kv channel dysfunction on neuronal physiology . - pubmed
The studies described in this review thus underscore the importance of normal Kv channel function in neurons and emphasize the therapeutic potential of targeting Kv channels in the treatment of a wide range of neurological diseases . - pubmed
As confirmed by qRT - PCR , microarray data showed a significant ( P & lt ; .005 ) upregulation of cytokines and chemokines ( IL-6 , CCL2 , CXCL1 , AIMP1 , and CD44 ) just 5 hours after injury . - pubmed
Immunohistochemistry demonstrated that CCL2 and the adhesion receptor CD44 were expressed by SMCs in the early response to injury and in the absence of leukocyte infiltration . - pubmed
Diabetic patients have characteristic pattern of dyslipidemia with decreased level of high density lipoprotein cholesterol ( HDL - C ) and elevated triglycerides ( TG ) level . - pubmed
However , in diabetes mellitus , low density lipoprotein cholesterol ( LDL - C ) which is used as one of the markers for the risk of CVD , is underestimated so in such cases the levels of non - High density lipoprotein cholesterol ( non - HDL - C ) can be a stronger predictor of CVD as it strongly correlates with atherogenic lipoproteins . - pubmed
Diabetics have significantly elevated ratio of total cholesterol to high density lipoprotein cholesterol ( TC / HDL - C ) and the significant increased levels of non - high density lipoprotein cholesterol ( non - HDL - C ) compared to controls which can be used as markers of dyslipidemia and can also be used to predict the risk of cardiovascular disease in type 2 Diabetes Mellitus . - pubmed
18 - Fluorine fluorodeoxyglucose positron emission tomography in the pretreatment evaluation of thymic epithelial neoplasms : a metabolic biopsy confirmed by Ki-67 expression . - pubmed
We also searched for the expression of a pathological biomarker , Ki-67 , that gained both diagnostic and prognostic relevance for various solid tumours . - pubmed
CONCLUSIONS : FDG PET - CT can provide a useful tool in the preoperative work - up of TEN , reflecting its proliferation capacity , as described also by the Ki-67 expression . - pubmed
OBJECTIVE : A phase IIa study investigated efficacy and safety / tolerability of ascending doses of mavrilimumab ( anti - granulocyte - macrophage colony - stimulating factor receptor [ GM - CSFR ] alpha monoclonal antibody ) in adult subjects with moderate to severe rheumatoid arthritis from Japan and Europe . - pubmed
CONCLUSIONS : A rapid and clinically meaningful response was seen in subjects treated with GM - CSFRalpha blockade with mavrilimumab , supporting further investigation of mavrilimumab for the treatment of RA in Japanese subjects . - pubmed
Primary cutaneous CD30 - positive anaplastic large cell lymphoma in an 80 - year - old man : a case report from Nepal . - pubmed
MATERIAL AND METHODS : A series of three cases of positive anti - Ro / SS - A mothers with fetuses showing mild cardiac involvement were treated with a triple therapy composed of steroids , plasmapheresis and IVIG . - pubmed
Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin - like Growth Factor I Receptor Levels in Human Breast Cancer . - pubmed
PURPOSE : Epidemiologic studies indicate that dietary factors , such as coffee , may influence breast cancer and modulate hormone receptor status . - pubmed
The purpose of this translational study was to investigate how coffee may affect breast cancer growth in relation to estrogen receptor - alpha ( ER ) status . - pubmed
Cellular and molecular effects by the coffee constituents caffeine and caffeic acid were evaluated in ER(+ ) ( MCF-7 ) and ER(- ) ( MDA - MB-231 ) breast cancer cells . - pubmed
RESULTS : Moderate ( 2 - 4 cups / day ) to high ( & gt;=5 cups / day ) coffee intake was associated with smaller invasive primary tumors ( Ptrend = 0.013 ) and lower proportion of ER(+ ) tumors ( Ptrend = 0.018 ) , compared with patients with low consumption ( & lt;=1 cup / day ) . - pubmed
Moderate to high consumption was associated with lower risk for breast cancer events in tamoxifen - treated patients with ER(+ ) tumors ( adjusted HR , 0.51 ; 95 % confidence interval , 0.26 - 0.97 ) . - pubmed
CONCLUSIONS : The clinical and experimental findings demonstrate various anticancer properties of caffeine and caffeic acid against both ER(+ ) and ER (- ) breast cancer that may sensitize tumor cells to tamoxifen and reduce breast cancer growth . - pubmed
Relationship between pituitary adenoma texture and collagen content revealed by comparative study of MRI and pathology analysis . - pubmed
Preoperative imaging data of 38 cases of pituitary adenoma patients and collagen content of tumor specimens measured by histopathological were analyzed and compared . - pubmed
T2WI and diffusion coefficient assessment were used to reveal the relationship between tumor texture and collagen content . - pubmed
There were significant differences in collagen content of different texture tumors ( P & lt ; 0.01 ) . - pubmed
Elevated Serum Pentosidine and Decreased Serum IGF - I Levels are Associated with Loss of Muscle Mass in Postmenopausal Women with Type 2 Diabetes Mellitus . - pubmed
In this study , we investigated the relationship between serum levels of pentosidine , which is one of AGEs , and insulin - like growth factor - I ( IGF - I ) vs. skeletal muscle mass by whole body dual - energy x - ray absorptiometry in 133 postmenopausal women with type 2 diabetes . - pubmed
Moreover , after adjusting for age , duration of diabetes , serum creatinine , HbA1c , and IGF - I , pentosidine was significantly and negatively associated with RSMI ( beta=-0.27 , p=0.018 ) and marginally with muscle mass of legs ( beta=-0.18 , p=0.071 ) . - pubmed
These findings indicate that increased serum pentosidine and decreased IGF - I are independent risk factors for loss of muscle mass in postmenopausal women with type 2 diabetes . - pubmed
Randomized Controlled Trial of Zoledronic Acid plus Chemotherapy versus Chemotherapy Alone as Neoadjuvant Treatment of HER2 - Negative Primary Breast Cancer ( JONIE Study ) . - pubmed
METHODS : Asian patients with HER2 - negative invasive breast cancer were randomly assigned to either the CT or CT+ZOL ( CTZ ) group . - pubmed
SET8 induces epithelial - mesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1 . - pubmed
Mounting evidence suggested that histone H4K20 - specific methyltransferase SET8 is required to maintain the malignant phenotype of various cancer types ; however , the role of SET8 in mediating tumor metastasis in prostate cancer ( PCa ) has remained elusive . - pubmed
The present study demonstrated that small interfering RNA - mediated knockdown of SET8 inhibited the invasive potential of the PCa cell line PC-3 in vitro . - pubmed
Furthermore , SET8 was shown to be physically associated with the epithelial - mesenchymal transition ( EMT ) inducer zinc finger E - box - binding homeobox 1 ( ZEB1 ) in PCa cell lines . - pubmed
In conclusion , the present study revealed that SET8 and ZEB1 are functionally interdependent in promoting the EMT and enhancing the invasive potential of PCa cells in vitro . - pubmed
Sclerostin antibody prevented progressive bone loss in combined ovariectomized and concurrent functional disuse . - pubmed
A sclerostin - neutralizing antibody ( Scl - Ab ) increased bone mineral density in women with postmenopausal osteoporosis and healthy men . - pubmed
The objective of this study was to characterize the condition of bone loss in ovariectomized ( OVX ) rats with concurrent mechanical unloading and evaluate the effect of sclerostin antibody treatment in mitigating the prospective severe bone loss conditions in this model . - pubmed
The data suggested that monoclonal sclerostin - neutralizing antibody represents a promising therapeutic approach for severe osteoporosis induced by estrogen deficiency with concurrent mechanical unloading . - pubmed
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value . - pubmed
METHODS : We have investigated the expression of RECQ helicases in different hematological malignancies and in their normal counterparts using publicly available gene expression data . - pubmed
Furthermore , we explored whether RECQ helicases expression could be associated with tumor progression and prognosis . - pubmed
RESULTS : Expression of at least one RECQ helicase family member was found significantly deregulated in all hematological malignancies investigated when compared to their normal counterparts . - pubmed
In addition , RECQ helicase expression was associated with a prognostic value in acute myeloid leukemia , chronic lymphocytic leukemia , lymphoma and multiple myeloma . - pubmed
CONCLUSION : RECQ helicase expression is deregulated in hematological malignancies compared to their normal counterparts in association with a prognostic value . - pubmed
Deregulation of RECQ helicases appears to play a role in tumorigenesis and represent potent therapeutic targets for synthetic lethal approaches in hematological malignancies . - pubmed
Heat shock protein 27 ( HSP27 , HSPB1 ) is an anti - apoptotic protein characterized for its tumorigenic and metastatic properties , and now referenced as a major therapeutic target in many types of cancer . - pubmed
Therefore , altered dimerization of HSP27 represents a good strategy for anticancer therapy in HSP27 - overexpressing cancer cells . - pubmed
CONCLUSION : Bile deficiency in the intestine upregulates the expression of intestinal mucosal SGLT1 and enhances intestinal mucosal glucose absorption capacity , which contributes to the understanding of intestinal physiologic function for patients with biliary duct obstruction and external biliary drainage . - pubmed
Matriptase regulates c - Met mediated proliferation and invasion in inflammatory breast cancer . - pubmed
Dysregulation of matriptase expression , an epithelial - specific member of the type II transmembrane serine protease family , has been demonstrated in many different cancer types . - pubmed
To date , no studies have assessed the expression and potential pro - oncogenic role of matriptase in IBC . - pubmed
We examined the functional relationship between matriptase and the HGF / c - MET signaling pathway in the IBC cell lines SUM149 and SUM190 , and in IBC patient samples . - pubmed
Matriptase and c - Met proteins are localized on the surface membrane of IBC cells and their expression is strongly correlated in infiltrating cancer cells and in the cancer cells of lymphatic emboli in patient samples . - pubmed
Abrogation of matriptase expression by silencing with RNAi or inhibition of matriptase proteolytic activity with a synthetic inhibitor impairs the conversion of inactive pro - HGF to active HGF and subsequent c - Met - mediated signaling , leading to efficient impairment of proliferation and invasion of IBC cells . - pubmed
These data show the potential of matriptase inhibitors as a novel targeted therapy for IBC , and lay the groundwork for the development and testing of such drugs . - pubmed
This is a largest series of 5 cases of lymphoepithelioma - like carcinoma ( LEC ) of the breast attempting to look at the expression of basal cytokeratins ( CKs ) , human papillomavirus , and Epstein - Barr virus - encoded RNAs in these tumors . - pubmed
All tumors were negative for estrogen and progesterone receptors and HER2 ( triple negative ) . - pubmed
Three tumors expressed CK5 / 6 and high - molecular - weight CK , whereas only the case with nodal metastasis expressed CK14 . - pubmed
One patient with tumor expressing basal marker , CK5 / 6 , had contralateral breast malignancy after a duration of 53 months of treatment completion . - pubmed
The lymphoepithelioma - like carcinoma of breast expressed basal CK profile that is more CK5 / 6 positive than CK14 . - pubmed
Results from exomic sequencing revealed mutations in TP53 consistent with HGSOC . - pubmed
These results suggest the first evidence that curcumin can prevent Mn - induced microglial cell death through the induction of HO-1 and regulation of oxidative stress , mitochondrial dysfunction , and apoptotic events . - pubmed
Tuberculosis occurred on an atlantoaxial synovial pannus during juvenile idiopathic arthritis treated with TNF inhibitors . - pubmed
Complex Interplay Between Aging and Cancer : Role of TGF - beta Signaling . - pubmed
Although the fundamental roles of TGF - beta in cancer progression have been investigated extensively , recent reports also provide evidence for its direct or indirect links to aging - related processes such as cell proliferation , senescence , stem cell renewal , DNA damage , inflammation , and telomere length . - pubmed
In this review , we present the latest findings regarding the TGF - beta - regulated convergent and divergent mechanisms controlling the balance between aging and cancer . - pubmed
Estrogen - related receptors alpha , beta and gamma expression and function is associated with transcriptional repressor EZH2 in breast carcinoma . - pubmed
BACKGROUND : Orphan nuclear receptors ERRalpha , ERRbeta and ERRgamma that belong to NR3B or type IV nuclear receptor family are well studied for their role in breast cancer pathophysiology . - pubmed
Although function and regulation of ERRalpha , ERRgamma and less about ERRbeta is reported , role of histone methylation in their altered expression in cancer cells is not studied . - pubmed
The present study for the first time gives an insight into regulation of estrogen - related receptors by histone methylation specifically through methyltransferase EZH2 in breast cancer . - pubmed
Immunohistochemistry in primary breast tumors of different grades showed a correlated expression of estrogen - related receptors and EZH2 . - pubmed
Ectopic expression of EZH2 in low EZH2 - expressing normal breast epithelial cells abrogated their expression and at the same time , its silencing enhanced the expression of estrogen - related receptors in cancerous cells . - pubmed
CONCLUSION : Our findings identify EZH2 as a relevant coregulator for estrogen - related receptors in breast carcinoma . - pubmed
Abrogation of the Circadian Nuclear Receptor REV - ERBalpha Exacerbates 6 - Hydroxydopamine - Induced Dopaminergic Neurodegeneration . - pubmed
Considering our previous findings , we hypothesize that REV - ERBalpha may have a role in the onset and/or progression of PD . - pubmed
In the present study , we therefore aimed to elucidate whether genetic abrogation of REV - ERBalpha affects PD - related phenotypes in a mouse model of PD produced by a unilateral injection of 6 - hydroxydopamine ( 6 - OHDA ) into the dorsal striatum . - pubmed
In conclusion , the present study demonstrates for the first time that genetic abrogation of REV - ERBalpha can increase vulnerability of DAergic neurons to neurotoxic insults , such as 6 - OHDA , thereby implying that its normal function may be beneficial for maintaining DAergic neuron populations during PD progression . - pubmed
In this study the autophagy related proteins Beclin1 and ATG7 were tested as potential targets to sensitize colorectal carcinoma cells to ionizing radiation under normoxic , hypoxic and starvation conditions . - pubmed
Long - term improvement in renal , bone , lipid parameters , and CD4 / CD8 ratio in HIV - infected patients switching to a dual therapy with lamivudine plus boosted darunavir . - pubmed
Improvements in CD4 / CD8 ratio ( p = .04 ) , bone mineral density ( +1.17 % ; p = .07 ) , estimated glomerular filtration rate ( +7.7 mL / min in CKD patients ; p = .02 ) , urinary parameters ( proteinuria , -23 % ) , and overall cost ( -43 % ) were observed . - pubmed
The Effect of Early Response to GLP-1 RA Therapy on Long - Term Adherence and Persistence Among Type 2 Diabetes Patients in the United States . - pubmed
METHODS : Adults aged & gt;= 18 years with T2D initiated with GLP-1 RA therapy after January 1 , 2010 , were identified from the IBM Explorys Therapeutic Dataset . - pubmed
After controlling for baseline demographic and clinical characteristics including baseline weight , baseline A1c , oral antidiabetes drug use , insulin use , and the presence of comorbidity of diabetes , patients were more likely to be adherent over 18 months if they had reductions in A1c & gt ; 1 % ( OR = 1.59 , 95 % CI = 1.36 - 1.85 ) or body weight reduction & gt ; 3 % ( OR = 1.18 , 95 % CI = 1.02 - 1.36 ) at 3 - 6 months compared with those without an early response . - pubmed
The spectrum of conditions caused by abnormal CFTR function is broad - from ' classic ' cystic fibrosis ( CF ) to single organ conditions termed CFTR - related disorders . - pubmed
Calprotectin - g the lung during type 2 allergic airway inflammation . - pubmed
CONTEXT : X - linked acrogigantism ( X - LAG ) , a condition of infant - onset acrogigantism marked by elevated GH , IGF-1 , and prolactin ( PRL ) , is extremely rare . - pubmed
For more than 30 years , stable PRL , GH , and IGF-1 concentrations and serial imaging studies indicated no tumor recurrence . - pubmed
In both cases , many tumor cells expressed PRL , GH , and pituitary - specific transcription factor-1 . - pubmed
Furthermore , the tumor expressed other lineage - specific transcription factors , as well as SOX2 and octamer - binding transcription factor 4 , demonstrating the multipotentiality of X - LAG tumors . - pubmed
Both showed an elevated Ki-67 proliferation index , 5.6 % in the mother and 8.5 % in the infant , the highest reported in X - LAG . - pubmed
UHRF1 - KAT7 - mediated regulation of TUSC3 expression via histone methylation / acetylation is critical for the proliferation of colon cancer cells . - pubmed
Here , we show that Wnt / c - Myc signaling upregulates UHRF1 , which in turn downregulates TUSC3 , a candidate tumor suppressor gene that is frequently deleted or downregulated in several cancers . - pubmed
We also show that UHRF1 - mediated downregulation of TUSC3 is required for the proliferation of colon cancer cells . - pubmed
Our study provides evidence for the significance of UHRF1 - KAT7 - mediated regulation of histone methylation / acetylation in the proliferation of tumor cells and in a diverse set of biological processes controlled by Wnt / c - Myc signaling . - pubmed
Use of anti - vascular endothelial growth factor drugs for eye disease in Tuscany : Development and test of indicators of treatment intensity . - pubmed
Logistic and linear regression models were employed to explore relationships between air pollutants , blood lipids ( TC , TG , HDL - C and LDL - C ) and prevalence of dyslipidemias . - pubmed
Overall , increased air pollution exposure was related to increased TC and LDL - C , while decreased TG and HDL - C. Each 1 - mug / m3 increment of PM2.5 was related to 0.10 % ( 0.07%-0.19 % ) increase in TC , 0.63 % ( 0.50%-0.77 % ) increase in LDL - C , 2.93 % ( 2.70%-3.16 % ) decrease in TG , 0.49 % ( 0.38%-0.60 % ) decrease in HDL - C ; and 5.7 % ( 95%CI : 3.7%-7.6 % ) , 4.0 % ( 95%CI : 2.1%-6.0 % ) and 3.8 % ( 95%CI : 2.5%-5.1 % ) increase in odds for hypercholesterolemia , hyperbetalipoproteinemia and hypoalphalipoproteinemia , respectively . - pubmed
Attenuation of Inflammation and Leptin Resistance by Pyrogallol - Phloroglucinol-6,6 - Bieckol on in the Brain of Obese Animal Models . - pubmed
Activated macrophage infiltration , polarization of macrophages to a more inflammatory type ( M1 ) , and increased levels of pro - inflammatory cytokines are related to brain inflammation , which induces leptin resistance in the brain . - pubmed
In this study , we evaluated the effects of PPB effect M1 polarization and inflammation and its ability to restore the effects of leptin , such as a decrease in appetite and body weight . - pubmed
We administered PPB to diet - induced obesity ( DIO ) and leptin - deficient ( ob / ob ) mice , evaluated macrophage activation , polarization , and changes of inflammatory cytokine level in adipose tissue and brain , and determined the effect of PPB on leptin resistance or leptin sensitivity in the brain . - pubmed
PPB decreased inflammation in the brain , restored leptin sensitivity , and decreased food intake and weight gain in both DIO and ob / ob mice . - pubmed
The patient had normal albumin and renal function but was vitamin D deficient . - pubmed
A phase 1 study evaluating safety and pharmacokinetics of losatuxizumab vedotin ( ABBV-221 ) , an anti - EGFR antibody - drug conjugate carrying monomethyl auristatin E , in patients with solid tumors likely to overexpress EGFR . - pubmed
In this multicenter phase 1 study , eligible patients with EGFR - dependent solid tumors received losatuxizumab vedotin ( 3 + 3 design ) intravenously at starting dose of 0.3 mg / kg over 3 h per 21 - day cycle , with alternate dosing schedules utilized ( 2 weeks on/1 week off or weekly ) to mitigate infusion reactions . - pubmed
Tumor samples were evaluated for EGFR protein expression by immunohistochemistry , EGFR and EGFR ligand mRNA expression by RNAseq , and results compared with outcome . - pubmed
One HNC patient with increased levels of EGFR and EGFR ligands ( amphiregulin , epiregulin ) achieved a confirmed partial response . - pubmed
[ Expression Level of LKB1 Gene in Patients with Acute Lymphoblastic Leukemia and Its Correlation with Illness Condition ] . - pubmed
OBJECTIVE : To evaluate the expression level of LKB1 gene in patients with acute lymphoblastic leukemia ( ALL ) , and analyze its correlation with illness condition of patients . - pubmed
Patients in ALL group were divided into two groups according to the expression level of LKB1 gene : low expression group ( 39 cases ) and high expression group ( 17 cases ) . - pubmed
RESULTS : The expression level of LKB1 gene of control group was 1.56(1.38 - 1.74)>ALL group 1.32(1.22 - 1.40)>ANLL group 0.89(0.78 - 1.02 ) . - pubmed
There was negative relation between expression level of LKB1 gene and clinical risk level of ALL patients ( r=-0.712 , P=0.039 ) . - pubmed
For standard risk ALL , the patients in LKB1 low expression group was significantey lower than that in high expression group ; and for high risk ALL , the patients in LKB1 low expression group was significant higher than that in high expression group . - pubmed
Multivariate logistic analysis showed that the age ( OR=2.872 , P=0.020 ) , peripheral blood immature cell count ( OR=2.268 , P=0.028 ) were independent risk factors for survival of patients with ALL , and the expression level of LKB1 gene ( OR=0.426 , P=0.016 ) is protective factor . - pubmed
CONCLUSION : The expression level of LKB1 gene in patients with ALL is low , moreover the more low expression level of LKB1 gene were , the more severe ill condition and more poor prognosis were . - pubmed
Serum NO and H2O2 concentrations increased significantly and were related to muscle damage ( CK activity > 900 IU / mL ) in IHE and Arg / IHE compared to placebo . - pubmed
The understanding of the molecular landscape of BTC has offered hope of targeted therapies to the identified actionable genomic aberrations , such as FGFR2 gene fusions , mutations of IDH1 / 2 , HER2 , BRAC1 / 2 and BRAF . - pubmed
Pembigatinib has become the first approved targeted therapy for BTC with FGFR2 fusion or other rearrangements . - pubmed
Recent immunotherapy has opened new therapy avenues in BTC with pembrolizumab approved for either microsatellite instability high ( MSI - H ) or DNA mismatch repair deficient ( dMMR ) advanced solid tumors , including BTC . - pubmed
Electroacupuncture Pretreatment Alleviates LPS - Induced Acute Respiratory Distress Syndrome via Regulating the PPAR Gamma / NF - Kappa B Signaling Pathway . - pubmed
Excellent therapeutic success of the anti - interleukin 4 receptor - alpha antibody dupilumab in clinical trials and a real - world clinical context indicates the crucial roles of interleukin ( IL )- 4 and IL-13 in the pathogenesis of AD . - pubmed
Along with the clinical improvement in skin scores and pruritus , dupilumab significantly and progressively reduces and normalizes the upregulated expression of T helper type 2 signatures such as Chemokine ( C - C motif ) ligand ( CCL ) 17 , CCL18 , CCL22 , and CCL26 in the lesional skin of AD . - pubmed
Gene expression analysis in epileptic hippocampi reveals a promoter haplotype conferring reduced aldehyde dehydrogenase 5a1 expression and responsiveness . - pubmed
Here , we have scrutinized whether two linked regulatory SNPs ( rs2744575 ; 4779C > G and rs4646830 ; 4854C > G ) located in the aldehyde dehydrogenase 5a1 ( succinic semialdehyde dehydrogenase ; ALDH5A1 ) gene promoter are associated with expression of corresponding mRNAs in epileptic hippocampi ( n = 43 ) . - pubmed
Aberrant ALDH5A1 promoter regulation in functional terms can contribute to impaired gamma - aminobutyric acid homeostasis and thereby network excitability and seizure propensity . - pubmed
Objectives : Type I interferons ( IFNs ) inhibit regulatory T - cell ( Treg ) expansion and activation , making them beneficial in antiviral responses , but detrimental in autoimmune diseases . - pubmed
Methods : ISG15 expression and Treg dynamics were analysed in vitro and ex vivo from patients with chronic hepatitis C , with lupus and ISG15 deficiency . - pubmed
In vivo , in patients with chronic hepatitis C , 2 days after starting pegIFN / ribavirin therapy , a stronger ISG15 inducibility correlates with a milder Treg depletion . - pubmed
Ex vivo , in systemic lupus erythematosus patients , higher levels of ISG15 are associated to reduced STAT1 phosphorylation in response to IFNalpha , and also to increased frequencies of Tregs , characterising active disease . - pubmed
However , compared to the CON , IMO reduced the diarrhea rate of suckling piglets ( P < 0.05 ) and improved the concentrations of colostrum IgA , IgG , and IgM ( P < 0.05 ) . - pubmed
The use of amnion - derived cellular cytokine solution for the treatment of gingivitis : A two week safety , dose - ranging , proof - of - principle randomized trial . - pubmed
BACKGROUND : A 6 - week Phase I clinical trial was performed to primarily evaluate the safety and secondarily determine the preliminary efficacy of a novel biological solution , ST266 , comprised of a mixture of cytokines , growth factors , nucleic acids , and lipids secreted by cultured Amnion - derived Multi - potent Progenitor cells on gingival inflammation . - pubmed
Treatment of Herpesvirus saimiri ( HVS)-infected owl monkey cells by limited papain digestion removed the HVS - induced membrane antigen ( MA ) as determined by membrane immunofluorescence and antibody - dependent lymphocyte cytotoxicity ( ADLC ) . - pubmed
Effects of dietary magnesium supplementation on diurnal variations of blood pressure and plasma Na + , K (+)- ATPase activity in essential hypertension . - pubmed
These results support the view that oral magnesium supplementation is a useful approach to treatment of patients with uncomplicated essential hypertension , especially those with high plasmas renin activity . - pubmed
It appears that magnesium suppresses circulating Na + , K (+)- ATPase inhibitory activity to attenuate vascular tone , and thereby reduces blood pressure in EH . - pubmed
Proteinase - resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity . - pubmed
Multiple lines of evidence indicate that PrPSc , found only in scrapie , is a necessary component of the infectious scrapie agent . - pubmed
We measured the regional concentration of PrPSc in nine brain regions throughout the course of scrapie in the Syrian hamster following intrathalamic inoculation of prions . - pubmed
PrPSc was compared to the regional concentration of glial fibrillary acidic protein , a measure of reactive astrocytic gliosis . - pubmed
Brain PrPSc , determined by summing the concentrations in each brain region , correlated well with scrapie infectivity titers throughout the course of infection ( correlation coefficient = 0.975 ; slope of linear regression line = 1.136 ) . - pubmed
Our results support the hypothesis that PrPSc participates in both the etiology and pathogenesis of prion diseases . - pubmed
A dose finding study of a super long - acting luteinizing hormone - releasing hormone analog ( leuprolide acetate depot , TAP-144 - SR ) in the treatment of central precocious puberty . - pubmed
The effect of leuprolide acetate ( D - Leu6 -[ des - Gly10 - NH2 ]- LH - RH ethylamide acetate ) for depot suspension ( TAP-144 - SR ) , a synthetic analog of luteinizing hormone - releasing hormone , was examined in three doses in 36 patients ( 34 girls , 2 boys ) with central precocious puberty . - pubmed
A dose of more than 30 micrograms / kg of TAP-144 - SR is effective in suppressing gonadotropins and causing improvement of clinical symptoms , and appears to be useful in treating children with central precocious puberty . - pubmed
These patients were mostly men , had a family history of premature CAD , and 60 % ( 414 of 690 ) had high - density lipoprotein ( HDL ) cholesterol less than 0.90 mmol / liter ( 35 mg / dl ) . - pubmed
In a separate group of patients defined from the same admission population but having angiographically established CAD , 32 % ( 424 of 1,197 ) had a total cholesterol less than 5.17 mmol / liter ( 200 mg / dl ) , 59 % of whom ( 252 of 424 ) had HDL less than 0.90 mmol / liter ( 35 mg / dl ) . - pubmed
An analysis of persons admitted electively for angiography ( to exclude any effects of hospitalization per se on serum lipids ) revealed a similar proportion of persons with total cholesterol less than 5.17 mmol / liter ( 200 mg / dl ) ( 35 % ) , CAD ( 82 % ) , and HDL less than 0.90 mmol / liter ( 35 mg / dl). - pubmed
In cystic fibrosis amniotic fluids , measurements of fIALP antigen levels resulted in a lower false - negativity outcome than fIALP enzyme activity measurements , whereas in amniotic fluids of trisomy pregnancies fIALP enzyme activities and fIALP antigen levels were equally unpredictive . - pubmed
beta - Endorphin / beta - lipotropin immunoreactivity in endogenous depression . - pubmed
This study addresses the question of whether pituitary peptides ( ie , beta - endorphin ) show regulatory disruption in endogenous depression and , if so , does it co - occur in the same subjects who show cortisol dysregulation . - pubmed
Endogenously depressed patients and psychiatric controls from three centers were evaluated , when not taking medications , and studied for plasma cortisol and beta - endorphin levels . - pubmed
When abnormality of either the beta - endorphin or cortisol is considered it is clear that both levels of the hypothalamic - pituitary - adrenal axis can be dysregulated in endogenous depression . - pubmed
Antibodies to neurofilament protein in retinitis pigmentosa . - pubmed
Drug metabolite toxicity assessed in human lymphocytes with a purified , reconstituted cytochrome P-450 system . - pubmed
Exostoses have already been studied and explained by the action of BAPN ( lysyl oxidase ) . - pubmed
Additional analysis of IgM and fibrinogen was neither helpful in identifying neonatal infections nor a valuable follow - up parameter of successful treatment . - pubmed
In contrast C - reactive protein ( CRP ) was increased in 88 % of all infants with neonatal septicemia and/or meningitis at time of diagnosis ; when used in combination neutrophil indexes and CRP even improved the sensitivity of a single laboratory screening test . - pubmed
Effect of metabolic inhibitors on the agglutination of tumor cells by concanavalin A and Ricinus communis agglutinin . - pubmed
A collagen defect causing osteomalacia . - pubmed
The unsaturated vitamin B12 binding capacity ( UBBC ) of serum , the three transcobalamins ( TC I , TC II , TC III ) , and the total leucocyte and neutrophil counts have been studied in paediatric patients with sickle cell disease ( SCD ) . - pubmed
Species - specificity antigens , Forssman antigen and antigen similar to human B - isoantigen were revealed in the cells of both the intraspecies and all interspecies hepatoma hybrids . - pubmed
One mechanism of the immune suppression in HIV infection has been postulated as being caused by the interaction of HIV envelope glycoprotein gp120 with CD4 molecules . - pubmed
These studies indicate that the CD4 - gp120 interaction results in dysregulation of expression of costimulatory molecules , CD40L , and B71 expression on T cells and APC , respectively , thereby contributing to the T cell hyporesponsiveness in HIV infection . - pubmed
Coexpression of TGF alpha , epidermal growth factor receptor , and P - glycoprotein in normal and benign diseased breast tissues . - pubmed
Twenty - four normal or benign breast tissues were examined for the expression of transforming growth factor - alpha ( TGF alpha ) , epidermal growth factor receptor ( EGFR ) , and P - glycoprotein , the product of the mdr-1 gene . - pubmed
Coexpression of EGFR , TGF alpha , and P - glycoprotein in normal human breast tissues suggests a role for each of those proteins in normal breast physiology . - pubmed
An interaction may be present in normal breast tissue between the EGF receptor pathway and P - glycoprotein . - pubmed
Excitatory amino acid receptors and their role in epilepsy and cerebral ischemia . - pubmed
Increase in activated CD8 + cells in bronchoalveolar lavage fluid in patients with diffuse panbronchiolitis . - pubmed
DPB patients , however , had a higher number of lymphocytes and a reduced CD4 / CD8 ratio compared with the other subjects . - pubmed
A two - color analysis of T - cell subsets in peripheral blood and BALF revealed a significant increase in the percentage and number of CD8+HLA - DR+ cells and in the number of CD4+HLA - DR+ cells in BALF of DPB patients . - pubmed
The expression of the adhesion molecules CD 11a and CD18 on lung CD3 + cells was enhanced over that on blood CD3 + cells in DPB patients . - pubmed
There was no significant relationship between BALF interleukin ( IL )- 8 and lymphocyte accumulation in the lungs of the DPB patients , whereas a significant correlation between the percentage of neutrophils and IL-8 levels in BALF of DPB patients was observed . - pubmed
After treatment with macrolide antibiotics , a significant reduction in the number of lymphocytes and activated CD8 + cells and an elevation in the CD4 / CD8 ratio in BALF of DPB patients was observed . - pubmed
Effects of insulin therapy , however , were observed in later stages of DM : 71 % and 62 % survival in the 6- and 12 - week group , respectively . - pubmed
[ C - reactive protein in bacterial meningitis in adults ] . - pubmed
In order to assess the benefits of serial assays of C - reactive protein in the course of bacterial meningitis in adults , daily blood samples were taken for CRP measurement during 10 days in 21 consecutive patients ( mean age : 24 + /- 8 years ) hospitalized for bacterial meningitis principally due to Neisseria meningitidis ( n = 15 ) . - pubmed
The highest CRP level ( 178 + /- 38 mg / l ) was present on admission , followed by a regular decrease occurring in uncomplicated meningitis until normal level was achieved on day 9 . - pubmed
The benefit of CRP assays in optimizing the duration of antibiotic treatment of meningitis needs to be more carefully assessed . - pubmed
Memory deficits and cholinergic impairments in apolipoprotein E - deficient mice . - pubmed
Morris Water Maze tasks revealed impairments in working memory but not in reference memory of the apoE - deficient mice . - pubmed
In addition , hypothermia induced by the centrally acting muscarinic agonist , oxotremorine , was reduced in the apoE - deficient mice as compared to controls . - pubmed
Recent studies have identified multiple sequence variants of IRS-1 , especially in patients with non - insulin - dependent diabetes mellitus . - pubmed
These data indicate that the mutation in codon 972 in IRS-1 impairs insulin - stimulated signaling , especially along the PI 3 - kinase pathway , and may contribute to insulin resistance in normal and diabetic populations . - pubmed
This study looks at p53 protein expression in dysplastic and malignant lesions of the oral cavity using an immunohistochemical staining technique . - pubmed
Positive immunohistochemical detection of the p53 protein , demonstrated by brown nuclear staining , was detectable in over 80 % of mild , moderate and severe dysplastic tissues as well as carcinoma - in - situ and squamous carcinoma specimens . - pubmed
We concluded that p53 protein expression occurs frequently in both malignant and dysplastic lesions of the oral cavity , suggesting that abnormally detectable p53 protein is present at the very early stages of development of oral squamous carcinoma . - pubmed
Diminished TCR signaling in cutaneous T cell lymphoma is associated with decreased activities of Zap70 , Syk and membrane - associated Csk . - pubmed
The results obtained from analysis of tumor cells from four patients show a general reduction in basal and induced tyrosine phosphorylation of a wide range of signaling proteins . - pubmed
We propose that dampened TCR - triggered responses in CTCL are caused by suppression of an array of effector molecules required for coupling cell surface receptors to early and late signaling events . - pubmed
This new approach , taking advantage of the ability of truncated HIV envelope glycoproteins to be incorporated into heterologous retroviral particles , may foreseeably be used in future interventions based on the coordinated delivery of therapeutic gene products specifically to cell types susceptible to HIV infection . - pubmed
Results obtained in experimental animals indicate that AII - A effectively prevents the progression of renal injury . - pubmed
Several clinical studies are in progress , and the preliminary results suggest that AII - A has potent renal protective action in a variety of renal disorders . - pubmed
This study set out to investigate the importance of vomiting in producing the raised serum amylase and to clarify whether the amylase in pancreatic or salivary . - pubmed
METHODS : Patients suffering from hyperemesis gravidarum who were repeatedly vomiting in pregnancy but not binge eating had their total serum and pancreatic amylase measured . - pubmed
RESULTS : Results show 45 % ( 5 ) of bulimic patients had raised serum amylase , but none had a raised pancreatic amylase . - pubmed
DISCUSSION : Of patients with hyperemesis gravidarum who repeatedly vomit but do not binge , a significant number had raised amylase . - pubmed
This suggests that it is the vomiting rather than the binge behavior that increases amylase in bulimic patients . - pubmed
RESULTS : The serum BGP values were detected in normal subjects and six kinds of bone metabolic diseases . - pubmed
In 81 normal subjects , the average serum BGP level was ( 5.3 + /- 1.5 ) ng / ml and in postmenopausal osteoporosis the serum BGP level [ ( 6.2 + /- 1.9 ) ng / ml , n = 42 ] was higher than the normal ( P & lt ; 0.05 ) . - pubmed
The serum BGP levels were increased much in primary hyperparathyroidism [ ( 12.8 + /- 7.0 ) ng / ml , n = 21 , P & lt ; 0.001 ] . - pubmed
Increased values of BGP were also found in patients with chronic renal failure [ ( 8.5 + /- 2.4 ) ng / ml , n = 18 , P & lt ; 0.01 ] and Paget ' s disease [ ( 6.7 + /- 2.2 ) ng / ml , n = 12 , P & lt ; 0.05 ] . - pubmed
Decreased serum BGP values were found in Cushing syndrome [ ( 2.9 + /- 0.9 ) ng / ml , n = 16 , P & lt ; 0.001 ] and hypoparathyroidism [ ( 3.4 + /- 1.1 ) ng / ml , n = 42 , P & lt ; 0.001 ] . - pubmed
This result showed that in diseases with high bone turnover , the serum BGP levels were increased and in diseases with low bone turnover , the serum BGP levels were decreased . - pubmed
A mutation in the promoter of the multidrug resistance gene ( MDR1 ) in human hematological malignancies may contribute to the pathogenesis of resistant disease . - pubmed
The overexpression of the multidrug resistance gene MDR1 has been found to be associated with therapy - resistance in hematological malignancies . - pubmed
Point mutations in the MDR1 promoter have been found in osteogenic sarcoma ( Stein et al . - pubmed
We therefore analyzed DNA from hematological malignancies for MDR1 promoter point mutations . - pubmed
[ Mixed retinal thrombosis in a patient carrying prothrombin gene mutation in a homozygote state ] . - pubmed
The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ - line mutation of patched . - pubmed
Defects in a developmental signaling pathway involving mammalian homologues of the Drosophila segment polarity gene , patched ( ptc ) and its ligand , sonic hedgehog ( shh ) , contribute to tumor formation in several tissues . - pubmed
Recently , a subset of medulloblastoma , the most common malignant brain tumor in children , was found to contain somatic mutations in the human ptc gene . - pubmed
In addition , basal cell nevus syndrome ( BCNS ) , or Gorlin syndrome , which is characterized by developmental anomalies and a predisposition to skin and nervous system malignancies , is associated with germ - line mutation of ptc . - pubmed
Targeted disruption of both alleles of ptc in mice results in embryonic lethality . - pubmed
However , ptc+/- mice survive and develop spontaneous cerebellar brain tumors , suggesting that ptc may function as a tumor suppressor gene . - pubmed
Therefore , we investigated ptc+/-mice as a model for human medulloblastoma . - pubmed
We report that 14 % of ptc+/- mice develop central nervous system tumors in the posterior fossa by 10 months of age , with peak tumor incidence occurring between 16 and 24 weeks of age . - pubmed
Full - length ptc mRNA was present in all tumors analyzed , indicating that there was no loss of heterozygosity at the ptc locus . - pubmed
Nucleotide sequence of ptc mRNA from four tumors failed to identify any mutations . - pubmed
High levels of glil mRNA and protein were detected in the tumors , suggesting that the shh / ptc pathway was activated despite the persistence of ptc expression . - pubmed
beta - adrenergic blockade in developing heart failure : effects on myocardial inflammatory cytokines , nitric oxide , and remodeling . - pubmed
BACKGROUND : Whether beta - adrenergic blockade modulates myocardial expression of inflammatory cytokines and nitric oxide ( NO ) in heart failure is unclear . - pubmed
METHODS AND RESULTS : We administered oral metoprolol or no therapy to rats for 12 weeks after large myocardial infarction and subsequently examined left ventricular ( LV ) remodeling ; myocardial tumor necrosis factor ( TNF )- alpha , interleukin ( IL )- 1beta , and IL-6 expression ; and NO . - pubmed
Metoprolol administration starting 48 hours after infarction ( 1 ) attenuated ( P<0.02 ) LV dilatation and systolic dysfunction , ( 2 ) preserved isoproterenol responsiveness ( P<0.025 ) via NO - independent mechanisms , and ( 3 ) reduced myocardial gene expression and protein production of TNF - alpha and IL-1beta ( P<0 . - pubmed
CONCLUSIONS : During heart failure development , adrenergic activation contributes to increased myocardial expression of TNF - alpha and IL-1beta but not IL-6 , and one mechanism underlying the beneficial effects of beta - adrenergic blockade may involve attenuation of TNF - alpha and IL-1beta expression independent of iNOS and NO . - pubmed
Immunohistochemically , the tumor cells were positive for estrogen and progesterone receptors . - pubmed
Clinical phenotype and anti - desmoglein autoantibody profile in paraneoplastic pemphigus . - pubmed
BACKGROUND : Paraneoplastic pemphigus ( PNP ) has similar features to pemphigus vulgaris ( PV ) , including circulating anti - desmoglein ( Dsg ) IgG as pathogenic autoantibodies . - pubmed
When PV is divided into mucosal dominant type and mucocutaneous type , mucosal dominant type has only anti - Dsg3 IgG , whereas the mucocutaneous type has both anti - Dsg3 and anti - Dsg1 IgG. - pubmed
OBJECTIVE : The purpose of this study was to determine whether there is a difference in anti - Dsg autoantibody profile between mucosal dominant PNP and mucocutaneous PNP . - pubmed
CONCLUSION : There was no clear association between the clinical phenotype and anti - Dsg antibody profile in PNP as seen in PV . - pubmed
This finding suggests that besides anti - Dsg IgG other pathologic mechanisms such as lichenoid reaction or interface dermatitis may be involved in the blister formation in PNP . - pubmed
Effects of oral steroids on blood CXCR3 + and CCR4 + T cells in patients with bronchial asthma . - pubmed
In the steroid - treated asthma group , there was a decrease in CCR4 + T cells ( from 29.3 % to 20.3 % , p & lt ; 0.0001 ) , and an increase in CXCR3+/ CCR4 + ratio ( from 1.86 to 2.89 , p = 0.0047 ) , whereas there was no change in CXCR3 + T cells . - pubmed
These results suggest that short - term oral corticosteroid modulates the balances of CXCR3 + and CCR4 + cells in patients with asthma . - pubmed
The specific properties of the HER-2 / neu gene product as a tumor antigen , and the nature of the immune responses induced by effective preventive treatments are reviewed . - pubmed
Analysis of 25 Rec NciI alleles in Gaucher disease patients . - pubmed
An association between human immunodeficiency virus type I ( HIV-1 ) protease inhibitors ( PIs ) and galactorrhoea / hyperprolactinemia adverse effect has recently been reported in four HIV-1 - infected women treated with PIs ( indinavir , nelfinavir , ritonavir or saquinavir ) . - pubmed
We then examined the antitumor effect of cationic multilamellar liposome containing human IFN - beta ( huIFN - beta ) gene ( IAB-1 ) against RCC . - pubmed
The cytotoxicity of IAB-1 against human RCC ( NC65 , ACHN , and freshly isolated RCC cells ) , prostate and bladder cancer cell lines , and renal proximal tubule endothelial cells ( RPTEC5899 ) was examined by the colorimetric method using tetrazolium salt . - pubmed
RESULTS : The RCC cells treated with IAB-1 secreted significant amounts of huIFN - beta protein continuously . - pubmed
In contrast , treatment with 1000 IU / ml recombinant huIFN - beta protein resulted in weak cytotoxicity . - pubmed
The size of NC65 tumors transfected with IAB-1 in mice was significantly smaller than that receiving injection of empty liposome or recombinant huIFN - beta protein . - pubmed
To investigate the role of the A36R : A33R interaction during viral infection , five recombinant vaccinia viruses containing B5R - GFP as a marker were constructed . - pubmed
ALOPECIA PROBABLY DUE TO A MUCINOUS DEGENERATION OF THE CONNECTIVE TISSUE COMPONENT OF THE HAIR FOLLICLE ? - pubmed
Mucopolysaccharidosis IVA ( MPS IVA ) is a lysosomal storage disorder caused by the deficiency of N - acetylgalactosamine-6 - sulfate sulfatase ( GALNS ) . - pubmed
Mutation screening of the GALNS was performed by genomic PCR and direct sequence analyses in 20 MPS IVA patients from Latin America . - pubmed
There was also no apparent correlation between wbiI RFLP type and the ability of a single Bcc isolate to infect an individual with CF . - pubmed
[ The influence of medicine to the expression of cell adhesion molecule in experimental otitis media with effusion ] . - pubmed
OBJECTIVE : To study the influence of Cefaclor and Prednisonum to the expression of cell adhesion molecule in experimental otitis media with effusion ( OME ) . - pubmed
Cefaclor and Prednisonum may improve otitis media with effusion , which may related to the decreasing expression of Mac-1 and L - Selectin . - pubmed
An elevated erythrocyte sedimentation rate , C - reactive protein , tubular proteinuria and renal glucosuria returned to normal 2 weeks after treatment was started . - pubmed
Selenomethionine prevents degeneration induced by overexpression of wild - type human alpha - synuclein during differentiation of neuroblastoma cells . - pubmed
OBJECTIVE : High levels of wild - type alpha - synuclein are found in autopsied brain samples of idiopathic Parkinson ' s disease ( PD ) , some familial PD , some Alzheimer ' s disease ( AD ) and Down ' s syndrome with dementia . - pubmed
Bone marrow mammaglobin expression as a marker of graft - versus - tumor effect after reduced - intensity allografting for advanced breast cancer . - pubmed
We assessed mammaglobin ( MMG ) gene expression in bone marrow ( BM ) aspirates from patients with advanced breast cancer who had received a reduced - intensity conditioning and stem cell allografting , in order to detect a graft - versus - tumor effect on micrometastatic disease . - pubmed
In one case , a disease response occurring after donor lymphocyte infusion and grade II acute GVHD was heralded by negativization of MMG expression . - pubmed
IDO - expressing antigen - presenting cells are found in tumor - draining lymph nodes , where they can create a tolerogenic microenvironment . - pubmed
IDO can also be expressed within the tumor itself , by tumor cells or host stromal cells , where it can inhibit the effector phase the immune response . - pubmed
Strategies to inhibit the IDO pathway may thus assist in breaking tolerance to tumors , and might enhance the efficacy of other immunotherapy strategies by removing unwanted counter - regulation . - pubmed
Third - generation cephalosporins and beta - lactam / beta - lactamase inhibitor antibacterials as well as clindamycin or metronidazole are often required to provide broad - spectrum coverage for polymicrobial infections . - pubmed
GM - CSF deficiency reduces macrophage PPAR - gamma expression and aggravates atherosclerosis in ApoE - deficient mice . - pubmed
OBJECTIVE : Granulocyte - macrophage colony - stimulating factor ( GM - CSF ) is expressed in atherosclerotic lesions but its significance for lesion development is unknown . - pubmed
Consequently , we investigated the significance of GM - CSF expression for development of atherosclerotic lesions in apolipoprotein E - deficient ( apoE (-/- ) ) mice . - pubmed
We measured lesion size , macrophage , smooth muscle cell , and collagen accumulation at the aortic sinus , and expression of genes that regulate cholesterol transport and inflammation . - pubmed
Lesion size in hyperlipidemic apoE(-/-).GM - CSF(-/- ) increased by 30 % ( P<0.05 ) , macrophage accumulation doubled , and collagen content reduced by 15 % ( P<0.05 ) ; smooth muscle cell accumulation and vascularity were unaffected . - pubmed
CONCLUSIONS : GM - CSF deficiency increases atherosclerosis under hypercholesterolemic conditions , indicating antiatherogenic role for GM - CSF . - pubmed
We suggest this protective role is mediated by PPAR - gamma and ABCA1 , molecules that affect cholesterol homeostasis and inflammation . - pubmed
BACKGROUND & amp ; AIMS : Changes in mitochondrial energy metabolism promoted by uncoupling proteins ( UCPs ) are often found in metabolic disorders . - pubmed
Changes of serum beta - endorphin by programmed exercise training are correlated with improvement of clinical symptoms and quality of life in female mitral valve prolapse syndrome . - pubmed
Losartan preserves integrity of cardiac gap junctions and PGC-1 alpha gene expression and prevents cellular apoptosis in remote area of left ventricular myocardium following acute myocardial infarction . - pubmed
This study tests the hypothesis that peroxisome proliferator activated receptor - gamma coactivator 1alpha ( PGC-1alpha ) and the integrity of gap junctions ( GJs ) were suppressed and the number of apoptotic bodies was increased in remote viable areas of left ventricle following acute myocardial infarction ( AMI ) , which can be reversed by losartan therapy . - pubmed
The results showed that mRNA expression of PGC-1alpha , integrated area ( microm(2 ) ) of clustered connexin43 ( Cx43 ) spots , and Cx43 GJs were substantially down - regulated and the number of apoptotic bodies was markedly increased in nontreated AMI rats compared with healthy control and losartan - treated AMI rats on day 14 following AMI ( all values of P & lt ; 0.001 ) . - pubmed
Down - regulation of GJs and PGC-1alpha gene expression and cellular death were frequently observed in remote viable areas of LV following AMI . - pubmed
Differential role of gonadotropin - releasing hormone on human ovarian epithelial cancer cell invasion . - pubmed
In this study , we examined the effects of gonadotropin - releasing hormone ( GnRH )- I ( the classical mammalian GnRH ) , GnRH - II ( a second form of GnRH ) , and GnRH receptor on invasion using two human ovarian carcinoma cell lines , OVCAR-3 and SKOV-3 . - pubmed
In addition , we found that GnRH - I and GnRH - II interfered with activation of the phosphatidylinositol-3 - kinase / AKT pathway that is well documented to stimulate proteolysis and invasion of ovarian cancer cells . - pubmed
Taken together , these observations suggest that GnRH - I and GnRH - II play key regulatory roles in ovarian tumor cell invasion and extracellular matrix degradation . - pubmed
Management of asthma in preschool children with inhaled corticosteroids and leukotriene receptor antagonists . - pubmed
Several recent studies have confirmed the efficacy and safety of both inhaled corticosteroids and leukotriene receptor antagonists in the management of early childhood asthma . - pubmed
Based on the current body of evidence , there is rationale for further investigation of these management strategies , including direct comparisons between inhaled corticosteroids and leukotriene receptor antagonists , as well as the role of long - acting beta - agonists , potentially targeting the subpopulations of early childhood with wheezing who are at highest risk for persistence of asthma symptoms . - pubmed
Elevated expression of Mcl-1 accompanies the development of various cancers , neurodegenerative disorders and also infectious diseases . - pubmed
Ablating expression of this protein may be an attractive therapeutic strategy in the treatment of various cancers , and the diseases where Mcl-1 may play a key role in apoptosis supression . - pubmed
Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes : experience of the PedPump Study in 17 countries . - pubmed
Recently investigation shows that cell discrepant response to the overexpression of different IGF-1 isoforms and the E - peptides , and more interestingly , IGF-1Ea , IGF-1Eb ( MGF ) and MGF E - peptide have potential to promote skeletal muscle regeneration , to prevent cardiac muscle loss and neural damage . - pubmed
Anemia was defined as hemoglobin & lt;/=13 g / dL ( men ) or & lt;/=12 g / dL ( women ) and/or use of erythropoietin ( EPO ) . - pubmed
Anemic patients ( 59.4 % ) had less sideremia ( 73.4 vs 81.2 microg / dL ; P = .008 ) , but no significant differences were observed for transferrin saturation index ( 25.9 % vs 25.5 % ) , ferritin ( 167 vs 171 ng / mL ) , iron insufficiency ( 26.5 % vs 36.2 % ) , pronounced ferropenia ( 20.4 % vs 20.1 % ) , folic acid ( 7.5 vs 6.6 ng / mL ) , or vitamin B12 ( 486 vs 530 pg / mL ) . - pubmed
IL-14 alpha , the nexus for primary Sjogren ' s disease in mice and humans . - pubmed
To evaluate the role of interleukin 14 alpha ( IL-14a ) in Sjogren ' s syndrome ( SS ) , we evaluated the expression of IL-14a in the peripheral blood lymphocytes ( PBL ) of patients with primary and secondary SS and normal controls by quantitative RT - PCR . - pubmed
In addition , transgenic IL-14a mice were analyzed from 6 weeks of age to death for both histological and immunological features of Sjogren ' s disease . - pubmed
Patients with both primary and secondary Sjogren ' s syndrome expressed IL-14a at statistically higher levels in their peripheral blood compared to normal controls matched for age , sex and ethnic group . - pubmed
Transgenic mice in which IL-14a expression was increased constitutively were previously demonstrated to develop hypergammaglobulinemia , autoantibodies , infiltration of the parotid glands with lymphocytes , mild immune - complex mediated renal disease and large B cell lymphoma . - pubmed
Thus IL-14a is important in the pathophysiology of Sjogren ' s disease . - pubmed
The IL-14a transgenic mouse is a novel animal model that can be utilized to understand the pathophysiology of Sjogren ' s disease . - pubmed
IGF - IR tyrosine kinase interacts with NPM - ALK oncogene to induce survival of T - cell ALK+ anaplastic large - cell lymphoma cells . - pubmed
Although it promotes the growth of stimulated hematopoietic cells , a direct role of IGF - IR in malignant lymphoma has not been identified . - pubmed
Approximately 85 % of ALK(+ ) ALCL cases harbor the translocation t(2;5)(p23;q35 ) , which generates the chimeric oncogene NPM - ALK . - pubmed
In the present study , we explored a possible role of IGF - IR in ALK(+ ) ALCL . - pubmed
Our results demonstrate that IGF - IR and IGF - I are widely expressed in ALK(+ ) ALCL cell lines and primary tumors . - pubmed
Antagonism of IGF - IR decreased the viability , induced apoptosis and cell - cycle arrest , and decreased proliferation and colony formation of ALK(+ ) ALCL cell lines . - pubmed
Our findings improve current understanding of the biology of IGF - IR and NPM - ALK and have significant therapeutic implications as they identify IGF - IR signaling as a potential therapeutic target in ALK(+ ) ALCL and possibly other types of malignant lymphoma . - pubmed
FW was identified in F(2:3 ) families by evaluating seedling leaf symptoms and vascular tissue damage at plant maturity under natural field infection conditions over 2 years . - pubmed
A core MYC gene expression signature is prominent in basal - like breast cancer but only partially overlaps the core serum response . - pubmed
BACKGROUND : The MYC oncogene contributes to induction and growth of many cancers but the full spectrum of the MYC transcriptional response remains unclear . - pubmed
In contrast , comparison to a panel of breast cancers revealed a strong concordance in gene expression between the Core MYC Signature and the basal - like breast tumor subtype , which is a subtype with poor prognosis . - pubmed
This concordance was supported by the higher average level of MYC expression in the same tumor samples . - pubmed
Phase I dose escalation pharmacokinetic assessment of intravenous humanized anti - MUC1 antibody AS1402 in patients with advanced breast cancer . - pubmed
Alterations in MUC1 glycosylation accompany the development of cancer and influence cellular growth , differentiation , transformation , adhesion , invasion , and immune surveillance . - pubmed
A 20 - amino - acid tandem repeat that forms the core protein of MUC1 is overexpressed and aberrantly glycosylated in the majority of epithelial tumors . - pubmed
AS1402 is a potent inducer of antibody - dependent cellular cytotoxicity ( ADCC ) , specifically against MUC1 - expressing tumor cells . - pubmed
The objective of this study was to determine the safety , tolerability , and pharmacokinetic ( PK ) characteristics of AS1402 monotherapy in patients with locally advanced or metastatic MUC1 - positive breast cancer that had progressed after anthracyclines- and taxane - based therapy . - pubmed
Novel cftr gene sequence variation in Serbian patient with idiopathic disseminated bronchiectasis . - pubmed
This paper reports a novel Cystic Fibrosis Transmembrane Conductance Regulator ( CFTR ) gene variant , 1811 + 1G-->T , detected in a 5 - year - old girl diagnosed with idiopathic disseminated bronchiectasis and negative sweat chloride test ( 17 mmol / L ) . - pubmed
A novel NUP98 / RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia . - pubmed
The involvement of RARG in a chimeric fusion transcript has not been reported previously in human leukemia . - pubmed
Cognitive deficits in Down syndrome : narrowing ' Down ' to Olig1 and Olig2 . - pubmed
Human beta defensins ( HBD ) 1 , HBD2 , and HBD3 are key elements of innate immunity that are secreted to neutralize / control the progression of infection . - pubmed
RESULTS : In comparison with basal conditions , the secretion profile of HBD1 remained without significant changes ; HBD2 level in CHD and AMN increased 1.9- and 1.4 - times , respectively , after stimulation with bacteria . - pubmed
HBD3 secretion level increased significantly ( 7.8 + /- 1.9 pg / micrograms ) in the CHD but only if the stimulus was applied on the AMN side . - pubmed
coli , results in a tissue specific secretion of HBD1 , HBD2 , and HBD3 mainly in the CHD , which is the first infected region during an ascending infection . - pubmed
After whole - body irradiation of repair - proficient and repair - deficient ( DNA - PK - and ATM - deficient ) mice , the formation and rejoining of DSBs was analyzed in SSCs of testis compared with somatic cells of other tissues by enumerating gammaH2AX- , MDC1- , and 53BP1 - foci . - pubmed
BACKGROUND : The sensitive and accurate detection of hepatitis B virus surface antigen ( HBsAg ) is critical to the identification of infection and the prevention of transfusion transmitted disease . - pubmed
CONCLUSIONS : An improved Abbott ARCHITECT HBsAg prototype assay with enhanced detection of HBsAg and HBsAg mutants , as well as equivalent specificity was developed for the detection , diagnosis , and management of HBV infection . - pubmed
CYP2C9 polymorphism in patients with epilepsy : genotypic frequency analyzes and phenytoin adverse reactions correlation . - pubmed
The distribution of variant CYP2C9 alleles and prevalence of phenytoin adverse reactions were hereby investigated in a population of patients diagnosed with epilepsy . - pubmed
METHOD : Allele - specific PCR analysis was carried out in order to determine frequencies of the two most common variant alleles , CYP2C9 * 2 and CYP2C9 * 3 in genomic DNA isolated from 100 epileptic patients . - pubmed
CONCLUSION : Our findings indicate an overall similar distribution of the CYP2C9 alleles in a population of patients diagnosed with epilepsy in the South of Brazil , compared to other samples . - pubmed
Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction : differences between mice and man . - pubmed
Stromal derived factor - 1 alpha ( SDF-1a ) and monocyte chemotactic factor 1(MCP-1 ) are detectable in peripheral blood after myocardial infarction ( MI ) . - pubmed
METHODS : Murine hearts were studied for expression of MCP-1 and SDF-1a at day 3 and day 28 following myocardial infarction to determine whether production is increased following MI . - pubmed
In addition , we studied the coronary artery and coronary sinus ( venous ) blood from patients with normal coronary arteries , stable coronary artery disease ( CAD ) , unstable angina and MI to determine whether these cytokines are released from the heart into the systemic circulation following MI . - pubmed
MCP-1 mRNA is upregulated following murine experimental MI , but SDF-1a is suppressed . - pubmed
There is less release of SDF-1a into the systemic circulation in patients with all stages of CAD including MI , mimicking the animal model . - pubmed
However MCP-1 release from the human heart following MI is also suppressed , which is the exact opposite of the animal model . - pubmed
CONCLUSIONS : SDF-1a and MCP-1 release from the human heart are suppressed following MI . - pubmed
This review focuses on the diverse role of co - stimulatory molecules of the B7 and tumour necrosis factor ( TNF )- superfamily and their downstream signalling effectors in atherosclerosis . - pubmed
In particular , the contribution of CD28 / CD80 / CD86 / CTLA4 , ICOS / ICOSL , PD-1 / PDL-1 / 2 , TRAF , CD40 / CD154 , OX40 / OX40L , CD137 / CD137L , CD70 / CD27 , GITR / GITRL , and LIGHT to arterial disease is reviewed . - pubmed
Probe functionality was validated using fluorescence and MR measurements as well as in vitro studies using cancer cells that overexpress folate receptors . - pubmed
METHOD : Hepatic function in the immunological liver injury model was evaluated by assessing the levels of ALT in plasma , and the content of MDA , ORAC , NO and iNOS mRNA in liver tissues . - pubmed
CONCLUSION : The results indicated that VSE exerted potential effects on immunological hepatitis and the mechanisms might be partly related to free radical scavenging activity and inhibit release of iNOS . - pubmed
Familial childhood gout with progressive renal impairment attributable to mutations of the uromodulin ( UMOD ) gene is associated with reduced uromodulin in the proximal tubule cilia . - pubmed
Familial juvenile hyperuricemic nephropathy ( FJHN ) is one of three similar clinical disorders associated with uromodulin gene mutations . - pubmed
Genetic studies of urate transportation and of uromodulin - related nephropathy emphasize the pivotal importance of the proximal tubule in uric acid homeostasis . - pubmed
Initial PSA & gt;20 ng / mL is generally considered an adverse prognostic feature in prostate cancer ( PCa ) . - pubmed
Our goals were to estimate the impact of radical prostatectomy ( RP ) on biochemical recurrence- ( BCR- ) free and cancer - specific survival ( CSS ) rates of PCa patients with PSA & gt;20 ng / mL , and to identify patients with favorable oncological outcome . - pubmed
Dyslipidemia , and especially atherogenic dyslipidemia , a combination of small low - density lipoproteins cholesterol ( LDL - C ) , decreased high - density lipoprotein cholesterol ( HDL - C ) and increased triglyceride ( TG ) concentrations , represents a major cardiovascular ( CV ) risk factor . - pubmed
Nuclear receptor peroxisome proliferator - activated receptors ( PPARs ) are involved in the regulation of lipid metabolism ; PPAR ligands are used to treat dyslipidemias . - pubmed
Fibrates target atherogenic dyslipidemia by increasing plasma HDL - C concentrations and decreasing small dense LDL ( sdLDL ) particles and TGs , thus contributing to dyslipidemia management , particularly in patients with diabetes ( DM ) or the metabolic syndrome ( MetS ) . - pubmed
M2a Mp are frequently termed " wound healing " Mp , as they express factors that are important for tissue repair . - pubmed
Survivin expression is an independent poor prognostic marker in lung adenocarcinoma but not in squamous cell carcinoma . - pubmed
Survivin is a member of the inhibitors of apoptosis and frequently overexpressed in various cancer cells . - pubmed
Overexpression of survivin in lung cancer cells attenuates antitumor effect of tyrosine kinase inhibitors . - pubmed
However , data from the previous studies on the clinicopathologic implication of survivin in non - small - cell lung carcinoma ( NSCLC ) are inconsistent . - pubmed
We investigated the expression of survivin in 373 cases of surgically resected NSCLC . - pubmed
In adenocarcinoma , the increased expression of survivin was associated with the presence of vascular invasion , lymph node metastasis , and tumor recurrences , but we did n't find any correlation with survivin expression and clinicopathological parameters in squamous cell carcinoma . - pubmed
Patients with high survivin expression had significantly shorter disease - free survival ( DFS ; 42.2 vs. 58.8 months ; p = 0.001 ) and shorter overall survival ( OS ; 60.8 vs. 71.5 months ; p = 0.009 ) than those with low survivin expression group in adenocarcinoma . - pubmed
In squamous cell carcinoma , the expression of survivin was not associated with prognosis of the patients ( DFS ; 48.9 vs. 48.7 months ; p = 0.837 , OS ; 61.0 vs. 62.4 months ; p = 0.771 ) . - pubmed
Multivariate analysis confirmed that survivin was an independent poor prognostic factor in adenocarcinoma ( DFS : hazard ratio ( HR ) , 1.687 ; 95 % confidence interval ( CI ) , 1.123 - 2.532 ; p = 0.012 ; OS : HR , 1.965 ; 95 % CI , 1.108 - 3.486 ; p = 0.021 ) . - pubmed
Our results suggest that survivin is an independent negative prognostic factor in adenocarcinoma , but not in squamous cell carcinoma . - pubmed
The different prognostic roles played by survivin in adenocarcinoma and squamous cell carcinoma highlights the biological differences between these two histologic types . - pubmed
Five major glioblastoma genetic alterations ( epidermal growth factor receptor ( EGFR ) , phosphatase and tensin homologue ( PTEN ) , Ki-67 , O6 - methylguanine - DNA methyltransferase ( MGMT ) and p53 ) were confirmed by immunohistochemistry and analyzed for correlation with the nTBV of each tumor . - pubmed
Ki-67 labeling index indicated significant positive correlation with the nTBV of the tumor ( p = .01 ) . - pubmed
7 - Hydroxymitragynine induces a potent antinociceptive effect on mouse acute pain through mu - opioid receptors . - pubmed
A recombinant hypoallergenic tropomyosin has been developed , which opens a new avenue in the treatment of shellfish allergy . - pubmed
Limited G x E effects were detected between variants in SLC6A4 and both panic / agoraphobia and post - traumatic stress . - pubmed
In addition , studies in CKD patients on angiotensin - converting enzyme inhibitors , angiotensin receptor blockers , and/or direct renin inhibitors have shown that aldosterone levels paradoxically rise in approximately 30 % to 40 % of patients on these renin - angiotensin system - blocking drugs . - pubmed
Hence , there is interest in using mineralocorticoid receptor blockers that directly target the inflammatory and fibrotic effects of aldosterone in CKD patients . - pubmed
A better understanding of mineralocorticoid receptor blocker pharmacology should help inform future research directions and clinical practice decisions as to how best to use these agents in CKD . - pubmed
The biofilm - associated protein ( Bap ) of Staphylococcus aureus is a high molecular weight cell - wall - anchored protein involved in biofilm formation , first described in bovine mastitis strains from Spain . - pubmed
Early onset ectopia lentis due to a FBN1 mutation with non - penetrance . - pubmed
Isolated ectopia lentis is usually autosomal dominant and commonly due to the mutations of FBN1 gene . - pubmed
In conclusion , we report on a case of early - onset autosomal dominant isolated ectopia lentis caused by FBN1 mutation that has previously been reported only in Marfan syndrome . - pubmed
Hepatocyte - Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High - Fat Diet . - pubmed
We showed previously that UBXD8 plays a key role in proteasomal degradation of lipidated ApoB in hepatocarcinoma cell lines . - pubmed
After 26 wk of a high - fat diet , UBXD8 - LKO mice exhibited macrovesicular steatosis in the periportal area and microvesicular steatosis in the perivenular area , whereas control mice exhibited steatosis only in the perivenular area . - pubmed
The results showed that depletion of UBXD8 in hepatocytes suppresses VLDL secretion , and could lead to periportal steatosis when mice are fed a high - fat diet . - pubmed
This is the first demonstration that an abnormality in the intracellular ApoB degradation mechanism can cause steatosis , and provides a useful model for periportal steatosis , which occurs in several human diseases . - pubmed
Anti - NMDA receptor encephalitis ( ANRE ) has been previously reported as a rare cause of nonconvulsive status epilepticus ( NCSE ) . - pubmed
Maximum abdominal aortic aneurysm diameter was the only factor that significantly affected the CD62P values ( p = 0.005 ) . - pubmed
Postoperative CD36 values were significantly correlated with total aneurysm volume ( p = 0.05 ) and were higher in endografts made from polyester ( p = 0.01 ) . - pubmed
Non - invasive prenatal detection of haemoglobin Bart ' s disease by cardiothoracic ratio during the first trimester . - pubmed
This non - invasive approach for the exclusion of Hb Bart ' s disease can be used in early pregnancy . - pubmed
A significant increase of both IgM and IgG antibody titres found in paired acute- and convalescent - phase serum confirmed the diagnosis of acute MSF . - pubmed
On the other hand , several lines of evidence support a role for CaSR in promotion of cell differentiation and inhibition of proliferation in neuroblastoma , a tumor arising from precursor cells of developing PNS . - pubmed
Furthermore , only K562 / HLA + CD80 / 86 + PD - L1 cells pulsed with HLA - A*24:02 - restricted Wilms tumor 1 ( WT1 ) peptide clearly expanded WT1 - specific CTLs from healthy donors . - pubmed
Surprisingly , the number of Gal-3 + and CD45 + cells decreased in the SVZ after cuprizone , suggesting inflammation was selectively reduced therein . - pubmed
Inflammation can regulate SVZ proliferation and indeed the number of phosphohistone H3 + ( PHi3 + ) cells decreased in the SVZ but increased in the CC in both genotypes after cuprizone treatment . - pubmed
Therefore , ER stress poses a promising target in colorectal cancers , which develop as a result of Wnt activating mutations . - pubmed
Here , we report that embryonic myogenic progenitors lacking the phosphatase and tensin homolog ( Pten ) exhibit enhanced proliferation and differentiation , resulting in muscle hypertrophy but fewer SCs in adult muscles . - pubmed
Cytochrome P450 - 2D6 Genotype Definition May Improve Therapy for Paroxysmal Atrial Fibrillation A Case of Syncope Following " Pill - in - the - Pocket " Quinidine plus Propafenone . - pubmed
We searched for evidence relating Cytochrome P450 - 2D6 phenotypes or genotypes to antiarrhythmic metabolism in order to judge whether this analysis might contribute to improved safety and effectiveness of antiarrhythmic medications commonly utilized in the treatment of atrial fibrillation . - pubmed
We also describe a patient in whom knowledge of his IM / PM CYP2D6 genotype might have prevented the only episode of syncope and myocardial stunning which developed during his 28 years of " Pill - in - a - Pocket " therapy . - pubmed
Loss of maternal chromosome 11 is a signature event in SDHAF2 , SDHD , and VHL - related paragangliomas , but less significant in SDHB - related paragangliomas . - pubmed
Germline mutations in the succinate dehydrogenase ( SDHA , SDHB , SDHC , SDHD , SDHAF2 ) or Von Hippel - Lindau ( VHL ) genes cause hereditary paraganglioma / pheochromocytoma . - pubmed
While SDHB ( 1p36 ) and VHL ( 3p25 ) are associated with autosomal dominant disease , SDHD ( 11q23 ) and SDHAF2 ( 11q13 ) show a remarkable parent - of - origin effect whereby tumor formation is almost completely dependent on paternal transmission of the mutant allele . - pubmed
Using fluorescent in situ hybridization , microsatellite marker and SNP array analysis , we demonstrate that loss of the entire copy of chromosome 11 is also frequent in SDHAF2 - related PGLs , occurring in 89 % of tumors . - pubmed
By contrast , both copies of chromosome 11 were found to be retained in 62 % of SDHB - mutated PGLs / PCCs , while only 31 % showed loss of maternal chromosome 11p15 . - pubmed
Genome - wide copy number analysis revealed frequent loss of 1p in SDHB mutant tumors and show greater genomic instability compared to SDHD and SDHAF2.These results show that loss of the entire copy of maternal chromosome 11 is a highly specific and statistically significant event in SDHAF2 , SDHD and VHL - related PGLs / PCCs , but is less significant in SDHB - mutated tumors , suggesting that these tumors have a distinct genetic etiology . - pubmed
Fecal Calprotectin in Cystic Fibrosis and Its Relation to Disease Parameters : A Longitudinal Analysis for 12 Years . - pubmed
OBJECTIVES : Fecal calprotectin ( FC ) is a marker of inflammation in the intestinal tract . - pubmed
We assessed FC levels longitudinally in patients with cystic fibrosis ( CF ) and evaluated the relation between FC results and relevant markers of disease . - pubmed
Pancreatic insufficiency ( ie , fecal elastase & lt;100 mug / g stool ) was associated with considerably higher FC values compared to normal pancreatic function ( median FC 68 vs 29 mug / g , P & lt ; 0.0001 ) . - pubmed
APOE epsilon4 status is associated with white matter hyperintensities volume accumulation rate independent of AD diagnosis . - pubmed
To assess the relationship between carriage of APOE epsilon4 allele and evolution of white matter hyperintensities ( WMHs ) volume , we longitudinally studied 339 subjects from the Alzheimer ' s Disease Neuroimaging Initiative cohort with diagnoses ranging from normal controls to probable Alzheimer ' s disease ( AD ) . - pubmed
Following adjustment for APOE status , these differences became nonstatistically significant suggesting that APOE epsilon4 genotype is the major driver of accumulation of WMH volume rather than diagnosis of AD . - pubmed
The density of mast cells c - Kit+ and tryptase+ correlates with each other and with angiogenesis in pancreatic cancer patients . - pubmed
Nevertheless , few data are available concerning the role of MCs positive to tryptase in primary pancreatic cancer angiogenesis . - pubmed
This study analyzed the correlation between mast cells positive to c - Kit receptor ( c - Kit+ MCs ) , the density of MCs expressing tryptase ( MCD - T ) and microvascular density ( MVD ) in primary tumor tissue from patients affected by pancreatic ductal adenocarcinoma ( PDAC ) . - pubmed
Tumor tissue samples were evaluated by mean of immunohistochemistry and image analysis methods in terms of number of c - Kit+ MCs , MCD - T and MVD . - pubmed
Our in vivo preliminary data , suggest that tumor microenvironmental MCs evaluated in terms of c - Kit+ MCs and MCD - T may play a role in PDAC angiogenesis and they could be further evaluated as a novel tumor biomarker and as a target of anti - angiogenic therapy . - pubmed
In this regard , glial cells express cannabinoid receptors and synthesize endocannabinoids , and cannabinoid drugs affect some functions of these cells that can be implicated in schizophrenia pathobiology . - pubmed
Predictive Value of CD4+/CD8 + Ratio in Patients with Breast Cancer Receiving Recombinant Human Thrombopoietin . - pubmed
Recombinant human thrombopoietin ( rhTPO ) is a key determinant of therapy for chemotherapy - induced thrombocytopenia ( CIT ) in patients with breast cancer . - pubmed
To assess the predictive value of preoperative inflammatory cells for response to rhTPO in breast cancer patients , a total of 198 female patients with breast cancer were enrolled between June 2011 and December 2016 in Liaoning Cancer Hospital . - pubmed
Among 83 patients with grade 2 CIT , plasma CD4+/CD8 + ratio was lower significantly in rhTPO responders than in rhTPO nonresponders ( 1.19 + - 0.47 vs. 2.22 + - 1.11 , P & lt ; 0.05 ) with 83 % accuracy , but we observed little significant differences in patients with grade 3/4 CIT ( 1.32 + - 0.51 vs. 2.25 + - 0.77 , P & lt ; 0.05 ) with 76 % accuracy . - pubmed
We conclude that pretreatment CD4+/CD8 + ratio is a convenient , easily measured predictive indicator for patients with breast cancer receiving rhTPO , especially in patients with grade 2 CIT . - pubmed
Acetyl - CoA promotes glioblastoma cell adhesion and migration through Ca2 + -NFAT signaling . - pubmed
Genes involved in integrin signaling and cell adhesion were identified as acetyl - CoA - responsive in glioblastoma cells , and we demonstrate that ATP citrate lyase ( ACLY)-dependent acetyl - CoA production promotes cell migration and adhesion to the extracellular matrix . - pubmed
Presepsin : A new marker of catheter related blood stream infections in pediatric patients : Reply to Rivera - Moran Javier et al . - pubmed
Currently , mutations in the kisspeptin system , MKRN3 , and DLK1 have been identified in sporadic and familial cases of CPP . - pubmed
Activation of CB1R in the PVN induces hyperphagia by modulating directly or indirectly orexigenic and anorexigenic signals ; however , interaction among these mediators has not been clearly defined . - pubmed
Some GABAergic terminals are negatively influenced by 5 - HT , suggesting that the hyperphagic effect of CB1R activation could involve changes in serotonergic and GABAergic signaling in the PVN . - pubmed
Accordingly , the present study was aimed to characterize the neurochemical mechanisms related to the hyperphagic effects induced by activation of CB1R in the PVN , studying in vitro and in vivo changes induced by direct activation these receptors . - pubmed
aeruginosa skin infection in a mouse model , and PlyPa91 protected mice in a lung infection model , making these lysins potential drug candidates for Gram - negative bacterial infections of the skin or respiratory mucosa . - pubmed
SBF2 - AS1 : An oncogenic lncRNA in small - cell lung cancer . - pubmed
The long noncoding RNAs ( lncRNAs ) SBF2 antisense RNA 1 ( SBF2 - AS1 ) was found to act as an oncogenic lncRNA in non - small - cell lung cancer ( NSCLC ) , but the role of SBF2 - AS1 in small - cell lung cancer ( SCLC ) was still unclear . - pubmed
The purpose of this study was to provide the clinical significance and biological function of SBF2 - AS1 in SCLC . - pubmed
In our results , SBF2 - AS1 was found to be upregulated in SCLC tissues compared with NSCLC tissues or adjacent normal lung tissues . - pubmed
Besides , SBF2 - AS1 expression was also elevated in SCLC cell lines compared with the normal bronchial epithelial cell line or NSCLC lines . - pubmed
Moreover , high expression of SBF2 - AS1 was associated with clinical stage , tumor size , lymph node metastasis and distant metastasis in SCLC patients . - pubmed
Survival analysis showed SCLC patients with high expression of SBF2 - AS1 had shorter overall survival than patients with low expression of SBF2 - AS1 , and high expression of SBF2 - AS1 acted as an independent poor prognostic factor for overall survival in SCLC patients . - pubmed
The study in vitro suggested inhibition of SBF2 - AS1 obviously depressed cell proliferation , migration , and invasion in SCLC . - pubmed
In conclusion , SBF2 - AS1 acts as a novel oncogenic lncRNA in SCLC . - pubmed
Polymorphisms in Adipokines in Mexican Children with Obesity . - pubmed
We propose to investigate the contribution of adipokines and cytokines polymorphisms and common BMI / obesity - associated loci , revealed in genome - wide association studies in Caucasian adult cohorts , with childhood obesity . - pubmed
Only both TMEM18 ( rs6548238 ; rs7561317 ) polymorphisms were found associated with obesity ( OR=0.5 , P=0.008 ) and were in linkage disequilibrium ( r2=0.87 ) . - pubmed
The linear regression showed that the rs7561317 polymorphism of TMEM18 is negatively associated with obesity . - pubmed
This report highlights the influence of TMEM18 in Mexican - Mestizo children obesity , while adipokine and cytokine polymorphisms were not associated with it . - pubmed
High expression of CXCL14 is a biomarker of lung adenocarcinoma with micropapillary pattern . - pubmed
We extracted differentially expressed genes with high expression levels in MPP samples , and chose VSIG1 , CXCL14 and BAMBI as candidate biomarkers for MPP . - pubmed
RT - qPCR analysis confirmed a significantly higher expression of VSIG1 ( P=0.03 ) and CXCL14 ( P=0.02 ) in MPP than others . - pubmed
In validation set of 4 MPP and 4 non - MPP samples , CXCL14 expression was validated to be significantly higher in MPP than in non - MPP ( P=0.04 ) . - pubmed
Comparing a total of 10 MPP and 20 non - MPP samples , the AUC of CXCL14 to distinguish MPP from others was 0.89 . - pubmed
In immunostaining of CXCL14 , the staining score was significantly higher in MPP cases than others , where not only MPP component but also other components showed heterogeneous staining in adenocarcinoma tissues with MPP . - pubmed
Moreover , higher staining score of CXCL14 significantly associated with poorer prognosis , in all patients ( P=0.01 ) or within cases at stage I - III ( P=0.01).In summary , we identified CXCL14 as a possible diagnostic biomarker of MPP . - pubmed
While immunotherapies and targeted therapies such as BRAF inhibitors have improved the prognosis , BM is still associated with poor outcome and a short survival . - pubmed
All consecutive patients treated between May 2014 and December 2017 for a newly diagnosed locally advanced or metastatic melanoma with available status for BRAF mutation were identified . - pubmed
Of interest , another mechanistic approach responds to considering the inhibition of the renin - angiotensin - aldosterone system ( RAAS ) , which is exacerbated in COVID-19 infection because the virus binds to the enzyme ACE2 , making more angiotensinII available to cause damage . - pubmed
Several cancer - related pathways were enriched , including the TGF - beta pathway , the focal adhesion pathway , and the JAK - STAT signaling pathway , and 20 prognostic ceRNA regulatory networks were subsequently identified . - pubmed
Here , we discuss how host genetic variation may influence cytokine responses to respiratory viral infections and , based on our current understanding of the role that cytokines play in viral pathogenesis , how this may influence disease severity . - pubmed
We hypothesized that HMGA1 is important in the function of mesenchymal stromal cells ( MSCs ) , which are known to modulate inflammatory responses due to sepsis . - pubmed
Taken together , these data demonstrate that expression of dnHMGA1 in MSCs provides a functional advantage of the cells when administered during bacterial sepsis . - pubmed
Emodin enhances cisplatin sensitivity in non - small cell lung cancer through Pgp downregulation . - pubmed
PKA - RIIbeta autophosphorylation modulates PKA activity and seizure phenotypes in mice . - pubmed
Dysfunctional PKA signaling is causally linked to the TLE . - pubmed
In the present study , we found the autophosphorylation level at serine 114 site ( serine 112 site in mice ) of PKA - RIIbeta subunit was robustly decreased in the epileptic foci obtained from both surgical specimens of TLE patients and seizure model mice . - pubmed
Notably , by using a P - site mutant that can not be autophosphorylated and thus results in the released catalytic subunit to exert persistent phosphorylation , an increase in PKA activities through transduction with AAV - RIIbeta - S112A in hippocampal DG granule cells decreased mIPSC frequency but not mEPSC , enhanced neuronal intrinsic excitability and seizure susceptibility . - pubmed
In contrast , a reduction of PKA activities by RIIbeta knockout led to an increased mIPSC frequency , a reduction in neuronal excitability , and mice less prone to experimental seizure onset . - pubmed
Collectively , our data demonstrated that the autophosphorylation of RIIbeta subunit plays a critical role in controlling neuronal and network excitabilities by regulating the activities of PKA , providing a potential therapeutic target for TLE . - pubmed
[ Alpha 1 antitrypsin in pulmonary fibrosis in children ] . - pubmed
Evidence is reviewed that 5 - HT ( 5 - hydroxytryptamine , serotonin ) acting through the 5 - HT3 receptor subtype can influence behaviour relevant to anxiety , schizophrenia and cognitive disorders , and that 5 - HT3 receptor antagonists such as ondansetron ( CAS 116002 - 70 - 1 ) can correct behavioural disturbance in the absence of effect on normal behaviour . - pubmed
The 5 - HT3 receptor antagonists exert a breadth of action over a wide dose range in rodent and primate models to inhibit aversive behaviour in animal models of anxiety and certain symptoms of withdrawal from drugs of abuse , alcohol , nicotine , diazepam and cocaine , to antagonise increased locomotor activity caused by mesolimbic dopamine excess , and facilitate performance in cognitive tests . - pubmed
The studies reveal an important role for 5 - HT3 receptors in the regulation of limbic - cortical functioning , and a critical role for 5 - HT3 receptor antagonists to establish the role of 5 - HT3 receptors in schizophrenia , anxiety , drug withdrawal phenomena and cognitive disturbance . - pubmed
In the active stage of UC , mucosal spermidine concentration was higher than in remission or in the controls , but the activities of ornithine decarboxylase and S - adenosylmethionine decarboxylase , rate - limiting enzymes of polyamine biosynthesis , were lower . - pubmed
In the active stage of UC , the mucosal level of mRNA coding for ornithine decarboxylase was lower than in the remission stage of UC or in the controls . - pubmed
The activity of spermidine / spermine N1 - acetyltransferase , the rate - limiting enzyme of polyamine degradation , was higher in the active stage of UC than in the remission stage of UC or in the controls . - pubmed
To analyze the proliferative capacity of CD4 + or CD8 + T - cell subsets of individuals infected with human immunodeficiency virus type 1 ( HIV-1 ) and to optimize the in vitro conditions for virus replication , CD4 + or CD8 + cells of HIV-1 - infected patients were selectively activated inside the whole peripheral blood mononuclear cell ( PMNC ) population by dual antibody stimulation . - pubmed
Ex vivo perfusion of rat kidneys with the endothelium binding lectin concanavalin A ( con A ) followed by rabbit anti con A IgG results in a subendothelial IC nephritis in glomerular capillaries ( GC ) and diffuse IC formation with complement ( C3 ) deposition in peritubular capillaries ( PC ) . - pubmed
The mapping of the deletion breakpoint within the DP cluster allows the orientation of the loci in the DP region with respect to the centromere as follows : centromere , DP beta 2 , DP beta 1 , DP alpha 1 , ( DQ , DR ) . - pubmed
Results of the " Tandem - E CKMB " immunoenzymometric procedure ( y ) for creatine kinase ( CK ; EC 2.9.3.2 ) were compared with electrophoresis ( x ) for 160 serum samples from patients suspected of having sustained myocardial infarctions . - pubmed
Hepatotoxicity was judged by plasma alanine aminotransferase and aspartate aminotransferase levels , hepatic cytochrome P-450 content , and liver histology . - pubmed
This differential response between resistant and susceptible mouse lines further supports an important role for ACF in the stepwise progression of colon cancer . - pubmed
BACKGROUND : Glutaminase , the principal enzyme of glutamine hydrolysis , breaks down glutamine to supply energy and intermediates for cell growth and is present in high concentrations in replicating tissues such as intestinal epithelium and malignant tumors . - pubmed
In the host with cancer , glutaminase activity in the gut mucosa diminishes as the tumor grows , but the regulation of this response is unknown . - pubmed
Because cytokines may regulate the altered glutamine metabolism that is characteristic of the host with cancer , we studied the effects of cytokines on gut mucosal glutaminase expression in vitro using the human enterocytic Caco-2 cell line . - pubmed
CONCLUSIONS : This IFN - gamma - mediated decrease in glutaminase activity may be one mechanism by which gut glutamine metabolism is diminished as the tumor grows and becomes the principal organ of glutamine use . - pubmed
Immunological detection of membrane - associated human luteinizing hormone correlates with gene expression in cultured human cancer and fetal cells . - pubmed
We have demonstrated the expression of membrane - associated hCG and its subunits and fragments by cells from 78 human cancer cell lines of different types and origins , indicating that such expression is a common phenotypic characteristic of cultured human malignant cells . - pubmed
Because human ( h ) LH beta has 80 % homology with hCG beta and is coded by one of the seven genes in the gene cluster located in chromosome 19 , it was important to determine whether hLH and its beta - subunit are also expressed as membrane - associated proteins by cells from human cancer cell lines . - pubmed
Thus , 11 cancer cell lines of different types and origins were adapted to grow in serumless medium , with Nutridoma - HU or SP as serum substitute , and analyzed by flow cytometry using two monoclonal antibodies directed to different conformational epitopes of intact hLH and a monoclonal antibody reacting with an epitope of hLH beta - free . - pubmed
Determination of translatable levels of hLH beta and hCG beta messenger RNAs ( mRNAs ) was performed in cells from some of the cancer cell lines , including the JEG-3 choriocarcinoma cell line , and in cells from a human fetal lung cell line . - pubmed
These findings were corroborated by the presence of translatable levels of hLH beta and hCG beta mRNAs in all of the cancer cell lines analyzed , indicating that the expression of these membrane - associated glycoproteins is a phenotypic characteristic of human cancer cells and that the activation of the hCG beta - hLH beta gene cluster is nonselective . - pubmed
The presence of translatable levels of hCG beta - hLH beta mRNAs in the cultured human fetal lung cells punctuates once more the in vivo and in vitro biochemical similarities between fetal and cancer cells . - pubmed
Association of ACE gene polymorphisms with coronary artery disease in a northern area of Japan . - pubmed
The insertion / deletion DNA polymorphism of the gene coding human angiotensin converting enzyme ( ACE ) was examined in 109 patients with coronary artery disease ( CAD ) and 93 non - coronary subjects ( NCS ) living in a northern part of Japan . - pubmed
Young MI showed similar frequencies in ACE gene polymorphisms to those in NCS , a pattern which differed from that seen in subjects with CAD ( p & lt ; 0.05 ) . - pubmed
The numbers of risk factors did not alter the frequency of ACE gene genotype among patients with CAD , however , in normotensives , the odds ratio of DD - genotype was significantly increased to 3.4 . - pubmed
Accordingly , ACE gene polymorphism may be associated with morbidity from CAD in Japanese living in northern Japan as has been noted in Caucasians , despite the lower frequencies of the D - allele in the Japanese population . - pubmed
The results indicate a genetic effect on sensitivity to humoral immune response modulation by uremic status , with deficient antibody production despite a normal T cell proliferative response to mitogen stimulation in short - duration renal failure in high responder mice . - pubmed
Increased methylation can deplete DA , NE , and 5 - HT ; increase acetylcholine ; and cause hypokinesia and tremors . - pubmed
In order to clarify the significance of p16 gene ( CDKN2 ) inactivation and its disease specificity among hematopoietic tumors , configurations of the p16 gene as well as those of the adjacent p15 and interferon alpha ( IFN alpha ) genes were examined in primary hematopoietic tumors . - pubmed
Loss of the p16 gene is frequent in and highly specific to lymphoid tumors among hematopoietic tumors . - pubmed
Gene deletions but not minute mutations should be the predominant mechanism of p16 gene inactivation in these types of tumors . - pubmed
Deletions of the p16 gene were frequently observed in tumors carrying chromosome 9p abnormalities while a significant number of cases showed loss of the p16 gene without chromosome 9p abnormalities . - pubmed
So far inactivation of p53 and Rb tumor suppressors have also been found in lymphoid tumors . - pubmed
In our study , we detected homozygous deletions of p16 gene in 20 % , loss of Rb protein in 28 % , and p53 gene alterations in 8 % of lymphoid tumors . - pubmed
Reduction in transforming growth factor - beta type II receptor in mouse lung carcinogenesis . - pubmed
Loss of growth inhibition by TGF - beta is thought to contribute to the development of many types of tumors . - pubmed
To examine the roles of TGF - beta1 , - beta2 , and - beta3 and TGF - beta RI and RII in chemically induced mouse lung tumorigenesis , we used immunohistochemical and in situ hybridization analyses to measure the expression of their proteins and mRNAs in A / J mice treated with the carcinogen urethane to induce lung adenomas . - pubmed
Immunostaining for the TGF - beta ligands and receptors was also detected in adenomas by 2 mo . - pubmed
While immunostaining for TGF - beta1 , - beta2 , and - beta3 and TGF - beta RI in adenomas was detected at levels comparable to those in bronchioles , immunostaining for TGF - beta RII was less intense in adenomas than in bronchioles . - pubmed
Decreased immunostaining for TGF - beta RII in adenomas persisted for at least 8 mo after exposure to urethane , whereas immunostaining for TGF - beta1 , - beta2 , and - beta3 and TGF - beta RI persisted at levels comparable to those in normal bronchioles . - pubmed
In situ hybridization studies conducted with TGF - beta receptor riboprobes showed a corresponding reduction in expression of TGF - beta RII mRNA but not of TGF - beta RI mRNA in adenomas compared with expression in bronchioles . - pubmed
Expression of TGF - beta RII mRNA was also examined in non - tumorigenic and tumorigenic mouse lung cells ; expression of TGF - beta RII mRNA was lower in the tumorigenic cells derived from urethane - induced lung tumors . - pubmed
Therefore the interaction between the hypothalamic stress hormone corticotropin releasing factor ( CRF ) and SP was investigated in AtT20 / D16v - cells , a cellular model derived from a pituitary tumor . - pubmed
Serum and peritoneal fluid levels of IGF I and II and insulinlike growth binding protein-3 in endometriosis . - pubmed
OBJECTIVE : To examine whether insulinlike growth factor I ( IGF I ) , IGF II and IGF binding protein 3 ( IGFBP 3 ) in serum and peritoneal fluid ( PF ) correlate with the presence and severity of endometriosis . - pubmed
CONCLUSION : IGF I may be an important mediator in the development and/or maintenance of endometriosis or progression to late - stage disease . - pubmed
Although it is clear that additional studies are required to design strategies for the improvement of the immunogenicity of CF proteins , our observations support the currently accepted view that secreted protein - based preparations may represent promising vaccine candidates for TB . - pubmed
Cytoplasmic localization of the interferon - inducible protein that is encoded by the AIM2 ( absent in melanoma ) gene from the 200 - gene family . - pubmed
The HGPS hens had significantly higher percentages of blood lymphocytes and CD4+:CD8 + ratios of circulating T cells ( P & lt ; 0.01 ) and tended to have more , but not significantly , gammadelta T cells ( P = 0.07 ) than the LGPS hens . - pubmed
The concentrations of plasma IgG were also significantly higher in the LGPS hens ( P & lt ; 0.01 ) . - pubmed
Biochemical defects in 11 - cis - retinol dehydrogenase mutants associated with fundus albipunctatus . - pubmed
Mutations in the gene encoding 11 - cis - retinol dehydrogenase ( RDH5 ; EC ) are associated with fundus albipunctatus , an autosomal recessive eye disease characterized by stationary night blindness and accumulation of white spots in the retina . - pubmed
The numbers of identified RDH5 mutations linked to fundus albipunctatus have increased considerably during recent years . - pubmed
Ganglioside GD1a inhibits HGF - induced motility and scattering of cancer cells through suppression of tyrosine phosphorylation of c - Met . - pubmed
HepG2 cells , a human hepatoma cell line , were used to investigate whether GD1a interferes with other cancer cells expressing c - Met . - pubmed
These results suggest that GD1a acts as a negative regulator of c - Met in cancer cells . - pubmed
Soluble TNF receptor fusion protein ( etanercept ) for the treatment of myelodysplastic syndrome : a pilot study . - pubmed
Blockade of tumor necrosis factor ( TNF ) alpha by a soluble TNF receptor fusion protein ( etanercept ; Enbrel ) improved in vitro hemopoiesis from the marrow of patients with myelodysplastic syndrome ( MDS ) . - pubmed
BACKGROUND : Invasive adenocarcinomas developing in the rat dorsolateral prostate on combined treatment with 3,2 '- dimethyl-4 - aminobiphenyl ( DMAB ) and testosterone propionate ( TP ) are biologically androgen - independent and lacking androgen receptor protein ( AR ) expression . - pubmed
The present study was conducted to assess the mechanisms underlying this loss of AR expression in rat prostate cancer . - pubmed
METHODS : The methylation status of the AR gene promoter region in rat prostate cancer and cell lines ( PLS10 , 20 , and 30 ) was examined by Southern blotting , methylation - specific polymerase chain reaction , and methylation - sensitive single - strand conformation analysis ( MS - SSCA ) . - pubmed
RESULTS : AR mRNA expression was not detected in any of the rat prostate cancers or cancer cell lines tested by Northern blot analysis . - pubmed
The CpGs suggested to be responsible for AR expression in rat prostate cancer were found to be located -9 and -1 nucleotides upstream of the transcriptional initiation site . - pubmed
CONCLUSIONS : These data clearly demonstrate that aberrant hypermethylation in the AR promoter region may play a critical role in AR expression in rat prostate cancers . - pubmed
Inducible nitric oxide synthase expression in the ischemic core and penumbra after transient focal cerebral ischemia in mice . - pubmed
The present observations examined the hypothesis that the iNOS expression in the ischemic penumbra after a transient focal ischemic insult is involved in the recruitment of penumbra into infarction . - pubmed
The time course of iNOS protein , enzymatic activity and NO concentration in the penumbra but not in the core matched the process of infarct maturation . - pubmed
at 6 and 12 h after reperfusion inhibited iNOS activity by 88.0 + /- 10.4 % and reduced NO concentration by 48.5 + /- 8.3 % in the penumbra , and lessened infarct size by 48.8 + /- 7.2 % . - pubmed
These results suggest that iNOS expression in the ischemic penumbra is involved in the recruitment of penumbra into infarction and thereby contributing to the enlargement of infarct . - pubmed
Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet - induced obesity . - pubmed
BACKGROUND : Elevated glucocorticoid production and reduced hypothalamic POMC mRNA can cause obese phenotypes . - pubmed
Conversely , adrenalectomy can reverse obese phenotypes caused by the absence of leptin , a model in which glucocorticoid production is elevated . - pubmed
We hypothesized that adrenalectomy would increase hypothalamic POMC mRNA and reverse obese phenotypes in obesity due to a high - fat diet as it does in obesity due to leptin deficiency . - pubmed
The high - fat diet increased body weight , adiposity , and plasma leptin , led to impaired glucose tolerance , and slightly stimulated hypothalamic proopiomelanocortin ( POMC ) expression . - pubmed
CONCLUSION : These data suggest that neither reduction of plasma glucocorticoid levels nor elevation of hypothalamic POMC expression is effective to significantly reverse diet - induced obesity . - pubmed
The purpose of this study was to determine the frequency and type of HPV associated with vulvar SK ( VSK ) and to compare expression of biomarkers ( p16 , Mib-1 , and cyclin E ) in these lesions . - pubmed
Increased Mib-1 staining was significantly more common in VSKs than in other vulvar lesions , but not in CSKs ; increased p16 and cyclin E staining was not more common . - pubmed
Unlike the cervix , p16 and cyclin E will not consistently distinguish VSKs from HPV - negative lesions due to underexpression in low - risk HPV infections ( p16 ) and less - restricted expression in vulvar lesions ( cyclin E ) . - pubmed
Circulating endothelin ( ET ) levels are elevated in heart failure and positively correlated with severity of heart failure . - pubmed
Recent studies demonstrated arginine vasopressin ( AVP ) V2 mRNA expression was upregulated in the inner medullary collecting duct ( IMCD ) of cardiomyopathic hamsters ( CM ) . - pubmed
The goal of the present studies was to determine if ET-1 is involved in upregulating the expression of AVP V2 mRNA in the IMCD of CM by using a mixed ETA / ETB receptor antagonist bosentan . - pubmed
Our results showed plasma ET-1 levels increased in CM hamsters and related with the severity of heart failure . - pubmed
The effect of bosentan in normalizing the expression of AVP V2 and AQP2 mRNA in the IMCD of CM was confirmed by in situ hybridization studies . - pubmed
This study demonstrated that AVP V2 and AQP2 mRNA are upregulated in CM hamsters and these upregulations are attenuated by bosentan treatment , suggesting that ET-1 plays a role in upregulating the expression of AVP V2 mRNA in CM hamsters . - pubmed
[ Evaluation of CA72 - 4 as a tumor marker in patients with gastric cancer ] . - pubmed
The clinical efficacy of CA72 - 4 for gastric cancer was studied in comparison with CEA and CA19 - 9 . - pubmed
However , the positive rates of CEA and CA72 - 4 were significant higher in the cases with lymph node metastasis and curative grade B , C. The combination assay of CEA and CA72 - 4 was valuable because the tumor markers were considered to be independent of each other . - pubmed
In conclusion , CA72 - 4 is more important than CA19 - 9 as a tumor marker in gastric cancer patients . - pubmed
Here we show that mice lacking the endolysosomal aspartic proteinase cathepsin E spontaneously develop skin lesions similar to those of humans with AD when reared under conventional conditions but not under specific pathogen - free conditions . - pubmed
These results strongly suggest that the development of AD in cathepsin E - deficient mice is initiated by systemic accumulation of IL-18 and IL-1beta , mainly due to their reduced turnover rates . - pubmed
In addition , the reduced expression of cathepsin E was also observed in erythrocytes of both humans with AD and the AD mouse model NC / Nga . - pubmed
Cathepsin E deficiency might thus be responsible for the induction of AD in humans and mice . - pubmed
Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer . - pubmed
Aberrant methylation of a sodium co - transporter , solute carrier family 5 member 8 gene ( SLC5A8 ) , has been detected in a subset of colorectal cancers , suggesting SLC5A8 may also serve as a tumor suppressor . - pubmed
To further investigate the role of epigenetic inactivation of SLC5A8 expression in gastric cancer , we determined the methylation status of the SLC5A8 5 ' CpG island ( CGI ) in a panel of gastric cancer cell lines and primary gastric cancers . - pubmed
We detected methylation of the 5'CGI in ten of twelve gastric cancer cell lines , and five of those showed dense methylation , which correlated with the absence of SLC5A8 transcription . - pubmed
Aberrant methylation of SLC5A8 was also detected in 23 of 71 ( 30 % ) primary gastric cancers , indicating that epigenetic inactivation of SLC5A8 is not a cell - line - specific phenomenon . - pubmed
It thus appears that aberrant methylation of its 5'CGI and histone deacetylation play key roles in silencing SLC5A8 expression in gastric cancers . - pubmed
Depression of classic complement pathway components and high titers of anti - DNA , anti - nucleosome , or anti - Clq antibodies identify patients are increased risk of renal involvement or flares of nephritis . - pubmed
Mechanisms of adaptations for oxytocin neurones are reviewed , using challenge with systemic interleukin-1beta , simulating activation of immune signaling by infection , as a stressor of special relevance in pregnancy . - pubmed
Interleukin 1beta-511 C / T polymorphism and risk of aneurysmal subarachnoid haemorrhage . - pubmed
The p53 tumor suppressor protein is a DNA sequence - specific transcriptional regulator that , in response to various forms of cellular stress , controls the expression of numerous genes involved in cellular outcomes including among others , cell cycle arrest and cell death . - pubmed
Accuracy of epidermal growth factor receptor mutation analysis on the basis of small biopsy specimens in patients with nonsmall cell lung cancer . - pubmed
Effect of physical training on ventricular repolarization in type 1 long QT syndrome : a pilot study in asymptomatic carriers of the G589D KCNQ1 mutation . - pubmed
We hypothesized that controlled submaximal endurance training would not adversely affect ventricular repolarization in asymptomatic carriers of a KCNQ1 gene mutation of type 1 long QT syndrome ( LQT1 ) . - pubmed
CONCLUSION : In this pilot study of asymptomatic carriers of a KNCQ1 gene mutation , submaximal endurance training did not harmfully affect arrhythmia risk markers . - pubmed
Evolution of HCV infection is determined by the intensity of immune response , type of secreted cytokines and persistence of specific HCV T lymphocytes response . - pubmed
The omega3 - depleted rats also displayed liver steatosis , increased incorporation of long - chain polyunsaturated omega6 fatty acids in liver phospholipids and increased activity of liver Delta9 - desaturase . - pubmed
In particular , approaches such as hypoxia - conditionally replicating viruses , cellular vehicles , and gene therapy means to disrupt the hypoxia - inducible factor ( HIF ) signaling are outlined . - pubmed
Immunohistochemical analysis of glucose transporter-1 showed positive in endometrial tissue and negative in leiomyoma . - pubmed
Using these vignettes , we evaluated statistical associations linking a decision to increase the glucocorticoid dose to the value of PMR - AS , of its components ( VASph , visual analog scale for pain [ VASp ] , C - reactive protein level [ CRP ] , morning stiffness [ MST ] , and elevation of upper limbs [ EUL ] ) , or to the difference in these variables between the last 2 visits ( dPMR - AS , dVASph , dVASp , dCRP , dMST , and dEUL ) . - pubmed
Are beta - lactams related to higher morbidity and mortality in urinary tract infections caused by extended - spectrum beta - lactamase - producing Escherichia coli ? - pubmed
Vitamin E supplementation enhances hemoglobin and erythropoietin levels in mildly anemic adults . - pubmed
Efficacy of acetyl - cholinesterase - inhibitor ( ACHEI ) treatment in Alzheimer ' s disease : a 21 - month follow - up " real world " study . - pubmed
Long - term efficacy of acetyl - cholinesterase - inhibitor ( ACHEI ) treatment in mild - to - moderate Alzheimer ' s disease ( AD ) is of great relevance for clinical routine and has been investigated over a 21 - month period of treatment in a " real word " population . - pubmed
Remarkably , most of the genes were linked to FOS in an early hypoxia pathway . - pubmed
The gene expression of FOS also increased with longer exposure to hypoxia . - pubmed
We have shown that FOS - related genes , which have been implicated in early hypoxia as well as the development of breast cancers , were differentially expressed before and after surgery . - pubmed
Inflammation and tumor progression : a lesson from TNF - alpha - dependent FAK signaling in cholangiocarcinoma . - pubmed
We have shown that FAK plays a critical role in MMP-9 production and subsequent invasion of the cholangiocarcinoma activated by an inflammatory cytokine , TNF - alpha . - pubmed
As degradation of the ECM is a prerequisite step for the invasion and metastasis of cancer cells , we used an assay of gelatin - degrading MMPs by Zymography to clarify the characteristic feature of the matrix degrading systems of the cancer cells . - pubmed
Immunoprecipitation and western blot analysis together with site specific phosphorylated FAK antibodies showed aberrant FAK activity in inflammation - mediated tumor cells . - pubmed
We demonstrated the effectiveness of FAK siRNA treatment to prevent tumor invasion . - pubmed
Our observations suggested the importance of FAK as a therapeutic target for malignant neoplasm . - pubmed
Comparison of hand - carried ultrasound assessment of the inferior vena cava and N - terminal pro - brain natriuretic peptide for predicting readmission after hospitalization for acute decompensated heart failure . - pubmed
OBJECTIVES : We sought to compare the value of serial assessment with hand - carried ultrasound ( HCU ) of the inferior vena cava ( IVC ) with brain natriuretic peptide ( BNP ) to identify patients with acute decompensated heart failure ( ADHF ) who will be readmitted or seek emergency department treatment after hospital discharge . - pubmed
In this study , we developed an adenovirus for conditional replication in p53 - dysfunctional tumor cells that uses p53 - selective expression of a microRNA - network directed against essential adenoviral genes . - pubmed
Compared to a control virus that expressed a scrambled microRNA - network , antiviral RNAi selectively attenuated viral replication in cells with transcriptionally active p53 , but not in p53 - dysfunctional tumor cells where both viruses replicated equivalently . - pubmed
Since these results were confirmed by an in vivo comparison of both viruses after infection of p53 - knockout and normal mice , we could demonstrate that attenuated replication was indeed a result of p53 - selective exhibition of antiviral RNAi . - pubmed
Addressing the therapeutic applicability , we could show that the application of RNAi - controlled virus efficiently lysed p53 - dysfunctional tumors in vitro and in vivo but resulted in drastically reduced load of virus - DNA in the liver of treated mice . - pubmed
We have generated a broadly applicable adenovirus for selective destruction of p53 - dysfunctional tumors and thereby demonstrate that virus - encoded RNAi - networks represent an efficient and versatile tool to modify viral functions . - pubmed
Alzheimer ' s disease is characterised by regional neuronal degeneration , synaptic loss , and the progressive deposition of the 4 kDa beta - amyloid peptide ( Abeta ) in senile plaques and accumulation of tau protein as neurofibrillary tangles . - pubmed
Disturbances of APP processing and/ or synthesis in oligodendrocytes may account for some myelin disorders observed in Alzheimer ' s disease and other senile dementias . - pubmed
Here we modelled the synapse damage that occurs in prion diseases by measuring the amount of synaptophysin , a pre - synaptic membrane protein essential for neurotransmission , in cortical or hippocampal neurones incubated with the disease associated isoform of the prion protein ( PrP(Sc ) ) , or with the prion - derived peptide PrP82 - 146 . - pubmed
The addition of PrP(Sc ) or PrP82 - 146 caused a dose - dependent reduction in the synaptophysin content of PrP wildtype neurones indicative of synapse damage . - pubmed
Promoter histone H3 lysine 9 di - methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells . - pubmed
p16 , a well - known tumor suppressor gene , is frequently silenced in DNA hypermethylation manner in gastric cancer . - pubmed
Accordingly , we chose p16 to clarify whether there is a correlation among histone H3 lysine 9 ( H3 - K9 ) di - methylation , H3 - K9 acetylation , DNA methylation and p16 expression in human gastric cancer . - pubmed
These results suggest that H3 - K9 di - methylation , H3 - K9 acetylation and DNA methylation work in combination to silence p16 in gastric cancer . - pubmed
[ Orexin - A in hepatic reperfusion - induced liver injury in rats ] . - pubmed
OBJECTIVE : To explore the change of orexin - A expression in hepatic reperfusion and their association with liver injury , and to find out the role of orexin - A in traumatic stress responses . - pubmed
There was significant and positive linear correlation between the plasma orexin - A and serum glucose and total anti - oxidation capacity ; serum alanine transaminase in each reperfusion group was significantly higher , and liver damage was significantly alleviated at the later phase of the injury . - pubmed
CONCLUSION : Orexin - A undergoes significant changes during hepatic reperfusion , indicating that orexin - A participates in the modulation of hepatic reperfusion - induced liver injury and internal disorders . - pubmed
CONCLUSION : The JNK2 protein appears to have an essential role in desiccation - induced corneal epithelial disease by stimulating production of MMP-1 , MMP-9 , and cornified envelope precursors . - pubmed
Clinical Relevance The JNK2 protein could be a novel therapeutic target in dry eye disease . - pubmed
Mannose - binding lectin and ficolin-2 gene polymorphisms predispose to cytomegalovirus ( re ) infection after orthotopic liver transplantation . - pubmed
METHODS : OLT patients ( n = 295 ) were genotyped for recipient and donor SNPs in mannose - binding lectin ( MBL2 ) , Ficolin-2 ( FCN2 ) and MBL - associated serine protease ( MASP2 ) genes . - pubmed
RESULTS : Combined analysis of independently associated variant MBL2 [ HR 1.65 , p<0.02 ] and wild - type FCN2 [ 1.85 ; p<0.02 ] SNPs in the donor liver showed an increased risk of CMV infection for either and both risk genotypes [ HR 2.02 and HR 3.26 , respectively , p = 0.004 ] , especially in CMV Donor-/Recipient+ ( D-/R+ ) patients [ HR 4.7 and HR 10.0 , respectively , p = 0.01 ] . - pubmed
Multivariate Cox analysis showed a consistent stepwise increase in CMV infection risk with the gene profile of the donor [ up to HR 2.77 ; p<0.005 ] and the combined MBL2 and FCN2 donor - recipient mismatch profile [ up to HR 4.57 ; p<0.001 ] , independent from donor - recipient CMV serostatus , also at higher CMV ( re)infection cut - off values . - pubmed
CONCLUSIONS : MBL2 and FCN2 risk alleles of donor liver and recipient constitute independent risk factors for CMV infection after OLT . - pubmed
To investigate alterations in neurologic morphology and test the hypothesis that developmental Pb neurotoxicity is partially mediated through alterations in neuronal growth and transport function of axons , the changes of specific axon tracts in the embryonic zebrafish brain were observed with anti - acetylated alpha - tubulin staining at several developmental time points through 36hours post fertilization ( hpf ) . - pubmed
An overexpression of netrin2 at these two developmental stages suggests a novel role for this gene in regulating axonal density specific to Pb neurotoxicity . - pubmed
We have analysed the effects of both risk factors on p53 induction during HBV infection in HepaRG , a cell line with hepatocyte - like morphology that metabolizes AFB(1 ) and supports HBV infection . - pubmed
Conversely , HBV infection did not significantly modify AFB ( 1 )-DNA adduct formation or repair as assessed by immunodot - blot assay , and the induction of p53 in response to AFB ( 1 ) was similar in infected and non - infected HepaRG cells . - pubmed
Alzheimer ' s disease is characterized by the deposition of aggregates of the beta - amyloid peptide ( Abeta ) in the brain . - pubmed
A potential therapeutic strategy for Alzheimer ' s disease is the use of synthetic beta - sheet breaker peptides , which are capable of binding Abeta but unable to become part of a beta - sheet structure , thus inhibiting the peptide aggregation . - pubmed
Augmented TLR2 expression on monocytes in both human Kawasaki disease and a mouse model of coronary arteritis . - pubmed
METHODS : Recruited subjects fulfilled the criteria of KD and were admitted for intravenous gamma globulin ( IVIG ) treatment at the Kaohsiung Chang Gung Memorial Hospital from 2001 to 2009 . - pubmed
RESULTS : Both human KD patients and LCWE - treated mice developed coronary arteritis , myocarditis , valvulitis , and pericarditis , as well as elevated plasma levels of interleukin ( IL )- 2 , IL-6 , IL-10 , monocyte chemoattractant protein ( MCP )- 1 , and tumor necrosis factor ( TNF )- alpha in acute phase . - pubmed
Toll - like receptor ( TLR )- 2 , but not TLR4 surface enhancement on circulating CD14 + monocytes , was augmented in KD patients before IVIG treatment and in LCWE - treated mice , which declined in patients after IVIG treatment . - pubmed
CONCLUSION : This result suggests that that not only TLR2 augmentation on CD14 + monocytes might be an inflammatory marker for both human KD patients and LCWE - induced CAL mouse model but also this model is feasible for studying therapeutic strategies of coronary arteritis in human KD by modulating TLR2 - mediated immune activation on CD14 + monocytes . - pubmed
Chronic high glucose ( HG ) inflicts glucotoxicity on vulnerable cell types such as pancreatic beta cells and contributes to insulin resistance and impaired insulin secretion in diabetic patients . - pubmed
In this meta - analysis , we determined the prevalence of MPNs and their subtypes as well as JAK2V617F and its diagnostic role in these uncommon disorders . - pubmed
Prevalence of MPNs , JAK2V617F , and MPN subtypes were calculated using a random - effects model . - pubmed
In BCS , mean prevalence of MPNs and JAK2V617F was 40.9 % ( 95 % CI , 32.9%-49.5 % ) and 41.1 % ( 95 % CI , 32.3%-50.6 % ) , respectively . - pubmed
In PVT , mean prevalence of MPNs and JAK2V617F was 31.5 % ( 95 % CI , 25.1%-38.8 % ) and 27.7 % ( 95 % CI , 20.8%-35.8 % ) , respectively . - pubmed
JAK2V617F and MPNs were more frequent in BCS compared with PVT ( P = .03 and P = .09 , respectively ) . - pubmed
JAK2V617F screening in splanchnic vein thrombosis ( SVT ) patients without typical hematologic MPN features identified MPN in 17.1 % and 15.4 % of screened BCS and PVT patients , respectively . - pubmed
These results demonstrate a high prevalence of MPNs and JAK2V617F in SVT patients and show differences in underlying etiology between these disorders . - pubmed
Furthermore , these results validate routine inclusion of JAK2V617F in the diagnostic workup of SVT patients . - pubmed
Elevated serum endostatin levels is associated with favorable outcome in acute myeloid leukemia . - pubmed
The levels and the prognostic relevance of serum endostatin in AML patient is not fully clear . - pubmed
AIM : To evaluate serum levels of endostatin in acute myeloid leukemia patients before chemotherapy and after achieving complete remission and to correlate endostatin levels with patients outcome . - pubmed
RESULTS : Endostatin serum levels were not significantly different in the pretreatment AML patients as compared to that in normal controls ( P>0.05 ) . - pubmed
In AML patients the baseline endostatin levels were significantly lower than at CR ( P=0.001 ) . - pubmed
The prognostic value of sE was also evaluated by dividing AML patients into high and low sE groups using the 75 percentile sE levels of the patients group as cutoff . - pubmed
CONCLUSIONS : Elevated endostatin levels at AML diagnosis is a good prognostic marker for patients ' outcome . - pubmed
The impact of the receptor of hyaluronan - mediated motility ( RHAMM ) on human urothelial transitional cell cancer of the bladder . - pubmed
mRNA - expression levels of HA synthases ( HAS1 - 3 ) and HA - receptors ( RHAMM and CD44 ) were evaluated by real time RT - PCR in comparison to healthy bladder tissue as control . - pubmed
In vitro knock - down of RHAMM , CD44 and HAS isoenzymes was achieved by siRNA and lentiviral shRNA in J82 bladder cancer cells . - pubmed
J82 cells after knock - down of RHAMM were xenografted into male nu / nu athymic mice to monitor tumor progression in vivo . - pubmed
RESULTS : In invasive tumor stages RHAMM- , HAS1 and HAS2 mRNA - expression levels were elevated whereas HAS3v1 was reduced as compared to non - invasive tumors . - pubmed
Subsequently , Kaplan - Meier analysis revealed reduced bladder cancer specific survival in patients with high RHAMM mRNA and low HAS3v1 expression . - pubmed
Elevated RHAMM in invasive tumors was confirmed by RHAMM immunohistochemistry . - pubmed
Lentiviral RHAMM knock - down revealed reduced J82 cell proliferation in vitro and reduced xenograft tumor growth in vivo . - pubmed
CONCLUSION : The data suggest that RHAMM plays a crucial role in mediating progression of muscle - invasive bladder cancer and recommends RHAMM for further evaluation as a prognostic marker or therapeutic target in bladder cancer therapy . - pubmed
The laboratory diagnosis of dengue fever was based on the serological detection of IgM and IgG antibodies , detection of dengue NS1 antigen by enzyme - linked immunosobent assay ( ELISA ) , and detection of dengue virus DNA by RT - PCR . - pubmed
Typical laboratory findings were leukocytopenia and thrombocytopenia , a low CRP level , and elevated aminotransferase activity . - pubmed
In the diagnosis of acute dengue fever , preference should be given to highly sensitive and specific tests for the direct detection of dengue virus ( NS1 antigen and RT - PCR assays ) . - pubmed
We investigated , for the first time , the effects of alpha - thujone or beta - thujone administrated centrally on the fear / anxiety behaviour of 3 - day - old chicks in an Open Field and their modulation on the GABAA receptor . - pubmed
The recombinant human granulocyte colony - stimulating factor ( rhG - CSF ) is widely used for the treatment of granulopenia in humans . - pubmed
Data suggest that peripheral and spinal CaCC , and particularly anoctamin-1 , participates in the acute nociception induced by formalin as well as in the development and maintenance of secondary mechanical allodynia and hyperalgesia . - pubmed
Time - Dependent Thrombus Resolution After Tissue - Type Plasminogen Activator in Patients With Stroke and Mice . - pubmed
BACKGROUND AND PURPOSE : We investigated the relationship between the degree of thrombus resolution and the time from stroke onset or thrombus formation to intravenous tissue - type plasminogen activator ( tPA ) treatment . - pubmed
METHODS : In patients with stroke , we measured thrombus volume on thin - section noncontrast brain computed tomographic scans taken at baseline and 1 hour after tPA administration . - pubmed
We determined the association between the time from symptom onset to tPA treatment and the degree of thrombus resolution . - pubmed
In a C57 / BL6 mouse model of FeCl3 - induced carotid artery thrombosis , we investigated the effect of tPA administered at different time intervals after thrombus formation , using Doppler - based blood flow measurement . - pubmed
Thrombus was resolved by & gt;=50 % in 43 patients ( 25.1 % , good volume reduction ) and by & lt;50 % in 94 patients ( 55.0 % , moderate volume reduction ) 1 hour after tPA treatment . - pubmed
In the mouse model , as the interval between thrombus formation and tPA treatment increased , the initiation of recanalization was delayed ( P=0.006 ) and the frequency of final recanalization decreased ( P for trends=0.006 ) . - pubmed
CONCLUSIONS : Early administration of tPA after stroke onset is associated with better thrombus resolution . - pubmed
The most differentially expressed AT transcript when comparing non - pregnant and pregnant women corresponded to the IGF binding protein ( IGFBP )- 5 , the expression levels of which was found by subsequent quantitative real - time PCR to be lower in women with GDM vs women with NGT ( p & lt ; 0.0001 ) . - pubmed
The induction of adipose tissue IGFBP5 in pregnancy and its decrease in GDM point to the importance of the IGF-1 signalling pathway in AT expansion in pregnancy and GDM susceptibility . - pubmed
When present , the severity of periodontitis and its relationship with gender , smoking , age , corticosteroids dose and AR activity were assessed . - pubmed
No relationship between the severity of periodontitis and AR activity was found . - pubmed
BACKGROUND AND OBJECTIVES : Patients with severe influenza virus infection , multi - organ failure and organ replacement therapy may absorb and metabolize neuraminidase inhibitors differently . - pubmed
In blood samples , hypermethylated ALX4 , FBN2 , HLTF , P16 , TMEFF1 and VIM were associated with poor prognosis , hypermethylated APC , NEUROG1 , RASSF1A , RASSF2A , SDC2 , SEPT9 , TAC1 and THBD were detected in early stage CRC and hypermethylated P16 and TFPI2 were associated with CRC recurrence . - pubmed
In stool samples , hypermethylated BMP3 , PHACTR3 , SFRP2 , SPG20 , TFPI2 and TMEFF2 were associated with early stage CRC . - pubmed
Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington ' s disease . - pubmed
Genome - wide gene - based analysis suggests an association between Neuroligin 1 ( NLGN1 ) and post - traumatic stress disorder . - pubmed
We applied gene - based testing to GWAS data from the Grady Trauma Project ( GTP ) , a primarily African American cohort , and identified two genes ( NLGN1 and ZNRD1 - AS1 ) that associate with PTSD after multiple test correction . - pubmed
Although the top SNP from NLGN1 did not replicate , we observed gene - based replication of NLGN1 with PTSD in the Drakenstein Child Health Study ( DCHS ) cohort from Cape Town . - pubmed
NLGN1 has previously been associated with autism , and it encodes neuroligin 1 , a protein involved in synaptogenesis , learning , and memory . - pubmed
These findings support a contribution of the NLGN1 gene pathway to the neurobiological underpinnings of PTSD . - pubmed
The present study was aimed to investigate the role of curcumin in myocardial infarction ( MI ) and its potential mechanism involving transcription factor specific protein 1 ( SP1 ) . - pubmed
In vitro experiments , mouse cardiac myocytes ( MCM ) subjected to hypoxia after the incubation of curcumin , miR-7a / b and SP1 expression levels were detected by real - time PCR and western blot . - pubmed
CONCLUSION : Curcumin pre - treatment protected against hypoxia - induced cardiac myocytes apoptosis through the up - regulation of miR-7a / b and the down - regulation of SP1 expression . - pubmed
Cyr61 and YB-1 are novel interacting partners of uPAR and elevate the malignancy of triple - negative breast cancer . - pubmed
TNBC lacks established targets for breast cancer therapy , such as the estrogen receptor ( ER ) , progesterone receptor ( PR ) and the human epidermal growth factor receptor 2 ( HER2 ) . - pubmed
TNBC and respective cell lines often overexpress proteins of the urokinase plasminogen activator system ( uPAS ) including uPA , its receptor uPAR and inhibitor PAI-1 , which together with co - factors contribute to the malignancy of TNBC . - pubmed
Here , two novel interacting partners of uPAR , the cysteine - rich angiogenic inducer 61 ( Cyr61 ) and the Y - box - binding protein 1 ( YB-1 ) were identified and their differential expression demonstrated in TNBC cells as well as in tumors . - pubmed
In the TNBC cohort , both interactors significantly correlated with expression levels of cathepsin B , c - Met and the tumor grade . - pubmed
The interactions of uPAR with Cyr61 significantly correlated with expression levels of tumor - promoting biomarkers including plasminogen ( p=0.0014 ) , cathepsin B ( p=0.032 ) , c - Met ( p=0.0192 ) as well as with the tumor grade ( p=0.02 ) . - pubmed
As the novel interacting partners , also together with uPAR , contribute to tumor progression and metastasis , both may be potential therapeutic targets in breast cancer . - pubmed
A blinded , randomized , placebo - controlled , dose determination trial of lokivetmab ( ZTS-00103289 ) , a caninized , anti - canine IL-31 monoclonal antibody in client owned dogs with atopic dermatitis . - pubmed
Lokivetmab , a caninized anti - canine IL-31 monoclonal antibody , reduced pruritus and associated inflammatory skin lesions in a proof - of - concept study in dogs with AD . - pubmed
Acetylcholinesterase ( AChE ) , which is implicated in the pathophysiology of neurological disorders , is distributed along the axon and enriched at the presynaptic basal lamina . - pubmed
Aberrant AChE activity and ectopic axonal accumulation of the enzyme are associated with neurodegenerative disorders , such as Alzheimer ' s disease . - pubmed
Correlation of Tissue Transglutaminase with Modified Marsh Grading in Celiac Disease : A Prospective Cohort Study . - pubmed
OBJECTIVE : To find out correlation between serum anti - tissue transglutaminase immunoglobulin - A ( tTGA ) levels and Marsh grading on duodenal histopathology in Celiac disease ( CD ) . - pubmed
CONCLUSIONS : Serum tTGA levels can be used to predict villous atrophy and biopsy may be avoided in strongly suspected cases with more than 9 times of cut - offs . - pubmed
Myoepithelial carcinoma with RB1 mutation : remarkable chemosensitivity to carcinoma of unknown origin therapy . - pubmed
Exome sequencing revealed an inactivating mutation in RB1 which we believe to be the first such mutation to be reported in this cancer type . - pubmed
CONCLUSIONS : Given increasing evidence suggesting RB1 loss is associated with responsiveness to conventional chemotherapies , particularly platinum - based regimens , we hypothesize that this genetic feature predisposed chemosensitivity in our patient 's tumor . - pubmed
PCSK9 inhibition and atherosclerotic cardiovascular disease prevention : does reality match the hype ? - pubmed
Within this review we look at whether the potential provided by proprotein convertase subtilisin / kexin type 9 ( PCSK9 ) inhibition for prevention of atherosclerotic cardiovascular disease matches the excitement generated . - pubmed
RESULTS : Two patients had high titers of anti - CASPR2 ( contactin - associated protein - like 2 ) Abs in serum and CSF and fulfilled the diagnostic criteria of definite limbic encephalitis . - pubmed
DESIGN : Genetic , nutritional and anthropometric parameters were measured in 213 dyslipidemic ( LDL & gt;=115 mg / dL ) and 58 normolipidemic ( LDL<115 ) postmenopausal women . - pubmed
The majority of patients in both & gt;=50 and & lt;50 age groups received a non - nucleoside reverse transcriptase inhibitor - based regimen ( 89 % vs. 87 % ) , did not have AIDS at baseline ( 63 % vs. 62 % ) , and were male ( 59 % vs. 58 % ) . - pubmed
MAIN RESULTS AND THE ROLE OF CHANCE : Women with latent GTB were younger ( 29.8 + - 4.4 years vs. 30.8 + - 4.5 years ; P = 0.003 ) and , following adjustment for age , had significantly lower AMH [ Median ( IQR ): 2 ( 0.9 , 4.1 ) ng / ml vs 2.8 ( 1.3 , 5 ) ng / ml ; P = 0.01 ] and AFC [ Median ( IQR ): 7 ( 5 , 11 ) vs 8 ( 5 , 14 ) ; P & lt ; 0.001 ] . - pubmed
In normoxia , VHL suppresses HIF1a - mediated transcriptional response , which is characteristic to hypoxia . - pubmed
We showed that even without hypoxia , VHL inactivation leads to hypermethylation of the genome . - pubmed
We extracted 696 differentially expressed genes relative to a reported PC signature from the TCGA dataset ( n = 492 ) and built a 15 - gene signature ( SigMuc1NW ) using Elastic - net with 10 - fold cross - validation through analyzing their expressions at 1.5 standard deviation / SD below and 2 SD above a population mean . - pubmed
SigMuc1NW discriminates BCR with time - dependent AUC ( tAUC ) values of 76.6 % at 11.5 months ( 76.6%-11.5 m ) , 73.8%-22.3 m , 78.5%-32.1 m , and 76.4%-48.4 m. SigMuc1NW is correlated with adverse features of PC , high Gleason scores ( odds ratio / OR 1.48 , P & lt ; 2e-16 ) , and advanced tumor stages ( OR 1.33 , P = 4.37e-13 ) . - pubmed
SigMuc1NW remains an independent risk factor of BCR ( HR 2.44 , 95 % CI 1.53 - 3.87 , P = 1.62e-4 ) after adjusting for age at diagnosis , Gleason score , surgical margin , and tumor stage . - pubmed
Importantly , a 10 - gene subsignature SigMuc1NW1 predicts BCR in MSKCC ( P = 3.11e-15 ) and TCGA ( P = 3.13e-12 ) ; SigMuc1NW1 discriminates BCR at 18.4 m with tAUC as 82.5 % . - pubmed
Collectively , our analyses support SigMuc1NW as a novel and robust signature in predicting BCR of PC . - pubmed
The present study aims to investigate whether ONO-5046 , a novel neutrophil elastase inhibitor , could affect NETs formation and promote inflammation resolution . - pubmed
CONCLUSIONS : The neutrophil elastase inhibitor ONO-5046 suppresses ROS - associated NETs formation , which may lead to inflammation resolution . - pubmed
Lysine - specific demethylase 1 ( LSD1 ) has been reported to connect with a range of solid tumors . - pubmed
Thus , the exploration of LSD1 inhibitors has emerged as an effective strategy for cancer treatment . - pubmed
Conclusions : Compared to cells from healthy donors , sprout formation was more efficiently abrogated in HMVECs from diabetic patients by blocking matrix metalloproteinase activity . - pubmed
Background : Chimeric antigen receptors ( CARs ) represent a novel facet of modern day synthetic biology that exemplifies personalized medicine at work through their ability to harness and redirect a patient 's immune system to fight cancer . - pubmed
Body : By combining the target - specificity of antibodies to the effector capabilities of T cells , CARs have yielded high remission rates for many late staged and relapsed / refractory ( r / r ) hematological malignancies , including acute lymphoblastic leukemias ( ALL ) and Non - Hodgkin ' s lymphomas . - pubmed
Amitriptyline attenuates bleomycin - induced pulmonary fibrosis : modulation of the expression of NF - kappabeta , iNOS , and Nrf2 . - pubmed
Lung injury was evaluated through the histological examination and immunohistochemical detection of alpha - smooth muscle actin ( alpha - SMA ) in lung tissue , in addition to the biochemical assessment of pulmonary contents of hydroxyproline and transforming growth factor beta-1 ( TGF - beta1 ) . - pubmed
Amitriptyline not only prevents the depression and its drawbacks in patients suffering from pulmonary fibrosis but also it can suppress fibrosis through variable mechanisms mainly via inhibition of NF - kappabeta / TNF - alpha / TGF - beta pathway in addition to inhibition of Nrf2 and iNOS expression . - pubmed
lusitaniae strain for the expression of full - length FKS1 alleles harbouring known mutations contributing to reduced susceptibility or resistance to caspofungin , thus opening the way for the screening of other FKS1 / FKS2 mutations potentially involved in RES . - pubmed
Discordance of high PD - L1 expression in primary and metastatic urothelial carcinoma lesions . - pubmed
Immune checkpoint inhibitors ( ICI ) targeting PD -( L ) 1 are effective in select patients with advanced urothelial carcinoma ( UC ) . - pubmed
High PD - L1 expression enriches for response to ICIs ; however , the predictive value of PD - L1 expression is limited , which may be due in part to dynamic expression of PD - L1 in the tumor environment . - pubmed
We sought to characterize PD - L1 expression in primary UC and paired metastatic lesions to gain insight into the potential discordance of tumor PD - L1 expression during the metastatic process . - pubmed
MATERIALS AND METHODS : Immunohistochemical staining for PD - L1 using the SP-142 antibody was performed on primary tumors and matched metastatic specimens in 77 evaluable subjects with advanced UC . - pubmed
Correlation of PD - L1 expression in TCs and ICs was estimated using Spearman 's correlation coefficients ( rho , rho ) . - pubmed
RESULTS : High ( & gt;=5 % ) PD - L1 expression in primary and metastatic biopsies , respectively , was observed in 6.0 % and 7.7 % of TCs and in 14.5 % and 11.5 % of ICs . - pubmed
IC PD - L1 expression in primary tumors was not correlated with IC PD - L1 expression in paired metastatic lesions ( rho = 0.05 , P = 0.67 ) and there was poor agreement in high expression rates between primary and metastatic lesions in the IC compartment ( kappa= 0.086 ) . - pubmed
CONCLUSION : High PD - L1 IC expression is temporally and spatially discordant between primary and metastatic UC lesions . - pubmed
Future studies of PD -( L ) 1 targeted therapies in patients with metastatic UC may benefit from use of fresh biopsies of metastatic lesions to define PD - L1 expression when feasible . - pubmed
Cyclin - dependent kinase 7 inhibitor THZ2 inhibits the growth of human gastric cancer in vitro and in vivo . - pubmed
In this study , we analyzed TCGA data and found that upregulation of CDK7 frequently occurred in human gastric cancer . - pubmed
A potent and selective irreversible CDK7 inhibitor THZ2 was able to induce cell growth inhibition , cell cycle arrest at G2 / M phase and apoptosis with the increasing intracellular reactive oxidative species ( ROS ) levels in gastric cancer cells . - pubmed
Overall , our data showed that inhibition of CDK7 with THZ2 in gastric cancer presented outstanding anticancer effect in vitro and in vivo , suggesting that CDK7 is a potential therapeutic target for gastric cancer patients . - pubmed
Rab7 delays intervertebral disc degeneration through the inhibition of the p38MAPK pathway . - pubmed
The objective of this study is to determine whether Rab7 could delay intervertebral disc degeneration and study the mechanism . - pubmed
We chose old mice to established intervertebral disc degeneration model and study the effect of Rab7 on intervertebral disc by western blotting , quantitative real - time PCR , immunohistochemistry et al . - pubmed
With the aging of mice , the degree of intervertebral disc degeneration was aggravated and the expression of Rab7 was decreased . - pubmed
In addition , overexpression of Rab7 can reduce the degeneration of nucleus pulposus cells and reduce the levels of p38 and p - p38 . - pubmed
Rab7 is a protective factor for intervertebral discs and could delays intervertebral disc degeneration through the inhibition of the p38MAPK pathway . - pubmed
AAV9 - Mediated Cdk5 Inhibitory Peptide Reduces Hyperphosphorylated Tau and Inflammation and Ameliorates Behavioral Changes Caused by Overexpression of p25 in the Brain . - pubmed
Unlike Cdk5 / p35 , which is important for brain development , aberrant activity of Cdk5 / p25 plays a pathological role in neurodegenerative diseases , such as Alzheimer ' s disease , by inducing hyperphosphorylation of downstream substrates related to pathological progression . - pubmed
OBJECTIVE : First , we aimed to establish a p25 overexpression adult mouse model , then to evaluate whether CIP delivered by adeno - associated virus serotype 9 ( AAV9 ) can ameliorate neuronal toxicity induced by p25 . - pubmed
In addition , a significant learning decline and anxiety - like behavior were induced by p25 toxicity , and CIP treatment improved learning ability in p25 mice . - pubmed
CONCLUSION : AAV - mediated p25 overexpression mouse model is easy to construct to study p25 - induced neuronal toxicity . - pubmed
Application of CIP after p25 insult reverses the pathological changes and behavioral abnormalities . - pubmed
Overall , our results illustrated that JG caused apoptosis and autophagy via activating the ROS - mediated p53 pathway in human liver cancer cells in vitro and in vivo , which provided basic scientific evidence that JG serves as a potential anti - cancer agent . - pubmed
The Family of Chloride Channel Regulator , Calcium - activated Proteins in the Feline Respiratory Tract : A Comparative Perspective on Airway Diseases in Man and Animal Models . - pubmed
Members of the chloride channel regulator , calcium - activated ( CLCA ) family are considered to be modifiers in inflammatory , mucus - based respiratory conditions such as asthma and cystic fibrosis . - pubmed
In the airways of asthmatic cats , CLCA1 was strongly overexpressed , similar to human patients . - pubmed
Rosmarinic acid reverses non - small cell lung cancer cisplatin resistance by activating the MAPK signaling pathway . - pubmed
Mechanistically , RA inhibited NSCLC cell growth , arrested cell cycle , and induced apoptosis by activating MAPK and inhibiting the expression of P - gp and MDR1 , which correspondingly enhanced p21 and p53 expression . - pubmed
We demonstrate that RA is a potentially effective MDR reversal agent for NSCLC , based on downregulation of MDR1 mRNA expression and P - gp . - pubmed
The complex process of angiogenesis begins when cells within a tissue respond to hypoxia by increasing their production of vascular endothelial growth factor ( VEGF ) . - pubmed
Our results demonstrated that hypoxia - mimicking materials could induce VEGF secretion of bone marrow - derived mesenchymal stromal cells ( BMSCs ) , which provided a positive feedback loop for early blood vessel formation by stimulating migration and tube formation of human umbilical vein endothelial cells ( HUVECs ) . - pubmed
Results : The CAFs and NF cultured were proColXIalpha1+/VIM+ , proColXIalpha1 / alphaSMA+ and proColXIalpha1+/CK19 + in different proportions without differences among them , but the CAFs growth curve was significantly larger than that of the NF ( p < 0.05 ) . - pubmed
These proteins include EZH2 , Snail , eIF4E , and IMPDH , which are all overexpressed in NPC and correlated with poor prognosis . - pubmed
Our work suggests that NPC responds to ribavirin - mediated EZH2 , Snail , eIF4E , IMPDH , and mTOR changes and positions ribavirin for clinical evaluation as a potential addition to our NPC treatment armamentarium . - pubmed
The current standard biomarker for myocardial infarction ( MI ) is high - sensitive troponin . - pubmed
EV levels of CD62P , CD42a , CD41b , CD31 and CD40 increased in STEMI , and to a lesser extent in SA patients . - pubmed
An aggregate marker including EV concentration and CD62P / CD42a levels achieved non - inferiority to troponin , discriminating STEMI from controls ( AUC = 0.969 ) . - pubmed
In contrast to mice , myog-/- zebrafish are viable , but have hypotrophic muscles . - pubmed
Correlation between Genotype and Phenotype in 69 Chinese Patients with USH2A Mutations : A comparative study of the patients with Usher Syndrome and Nonsyndromic Retinitis Pigmentosa . - pubmed
It included abdominal pain ( 76.5 % ) , diarrhea(20.6 % ) , hematochezia(29.4 % ) , and abdominal mass(2.9 % ) , 85.3 % with B - symptoms , and abnormally elevated LDH in the serum(73.5 % ) . - pubmed
Conclusion : Primary intestinal ENKTL was commonly observed in men at young or middle age , and the most common symptom was abdominal pain , often with B - symptoms , abnormally elevated LDH in the serum . - pubmed
qRT - PCR analyses revealed that samples from all needles were suitable for the detection of PDAC subtype markers ( GATA6 and ZEB1 ) and splice variants associated with mutational status ( GAP17 ) as well as for the detection of contaminating tissue around PDAC cells . - pubmed
Mechanism of circadian regulation of the NRF2 / ARE pathway in renal ischemia - reperfusion . - pubmed
The nuclear erythroid 2 - related factor 2 ( NRF2)/antioxidant response element ( ARE ) pathway has been shown to provide strong protection against oxidative stress injury induced by renal ischemia - reperfusion ( IR ) . - pubmed
However , the endogenous regulatory mechanism of the NRF2 / ARE pathway in renal IR injury is incompletely understood . - pubmed
A rat model of renal IR was established by occlusion of the bilateral renal pedicle for 45 min , followed by reperfusion for 24 h. Renal injury was assessed by light microscopy and levels of serum creatinine , blood urea nitrogen and neutrophil gelatinase - associated lipocalin was measured using enzyme - linked immunosorbent assay . - pubmed
It can be concluded that the circadian rhythm of the NRF2 / ARE pathway controlled by the circadian clock is essential for regulating antioxidant stress in renal IR injury , which might prompt new therapeutic strategies associated with the diurnal variability of human kidney disease , including renal transplantation . - pubmed
However , an increase in oncogenic potential and a broadening of the tissue specificity of tumor formation occurs after retroviral transduction of erbB. - pubmed
High - titer IgG autoantibodies to the La / SS - B ribonucleoprotein ( RNP ) are a hallmark of patients with primary Sjogren ' s syndrome . - pubmed
In vivo induction of IL-6 by administration of exogenous cytokines and detection of de novo serum levels of IL-6 in tumor - bearing mice . - pubmed
We investigated the capacity of several recombinant cytokines to induce IL-6 in vivo in both normal and tumor - bearing ( TB ) mice . - pubmed
TB animals consistently produced more IL-6 in response to rhTNF - alpha than did normal mice ( 2 h after 4 micrograms rhTNF - alpha , TB = 24,100 HGF U / ml , non - TB = 3600 HGF U / ml of IL-6 ) . - pubmed
dose of rhTNF - alpha ( 4 micrograms / mouse / day ) for 5 days led to decreased IL-6 induction in TB animals by day 3 of treatment ( peak levels of IL-6 , day 1 = 72,800 HGF U / ml , day 3 = 23,400 HGF U / ml , day 5 = 26,400 HGF U / ml ) . - pubmed
Administration of rhIL-1 induced similar IL-6 levels ( TB = 10,025 and non - TB = 10,600 HGF U / ml ) in TB and normal mice . - pubmed
Single high doses of rhIL-2 , rhIFN - alpha A / D , and rmIFN - gamma induced lower but consistent levels of circulating IL-6 in mice with and without tumor . - pubmed
In addition , the sera of untreated TB mice contained levels of IL-6 which paralleled the extent of tumor burden ( serum IL-6 in day 30 MCA 106 TB mice = 420 HGF U / ml ) . - pubmed
The detection of de novo IL-6 was also confirmed in animals bearing tumors of different histologies ( the MCA 102 sarcoma , MCA 38 adenocarcinoma , and B16 melanoma ) . - pubmed
Although the exact role of IL-6 in TB animals remains to be elucidated , its known pleotrophic immune and metabolic effects may be important in the host response to malignancy . - pubmed
The potent inhibitor of platelet cAMP phosphodiesterase ( PDE ) HL 725 ( 9,10 - Dimethoxy-2 - mesitylimino-3 - methyl-3 , 4,6,7 - tetrahydro-2H - pyrimido ( 6,1 - A )- isoquinoline-4 - one - hydrochloride ) , was examined for its effects on human and rat platelet aggregation . - pubmed
Strong inhibitory effects are seen on collagen - induced platelet aggregation both in rat platelet - rich plasma ( PRP ) ( IC50 , 54 + /- 12 nM ) and whole blood ( IC50 , 57 + /- 25 nM ) . - pubmed
The nucleoside transport inhibitors , dilazep and dipyridamole which are non - inhibitory alone to platelet aggregation , strongly potentiate ( about 10 - fold ) the inhibitory action of HL 725 on collagen - induced platelet aggregation in human whole blood . - pubmed
However , if the whole blood is pretreated with adenosine deaminase , no inhibitory effect of dipyridamole plus HL 725 is seen on platelet aggregation . - pubmed
Functional and biochemical characteristics of a putative quisqualate - type receptor in rat striatum : effect of brain lesions . - pubmed
[ The TRH test in the pathogenetic diagnosis of paroxysmal atrial fibrillation ] . - pubmed
Exposure of SLE mononuclear cells to autologous ACS caused an increase ( approximately two - fold ) in IgG production and ISC numbers . - pubmed
A female patient with therapy - related acute non - lymphoblastic leukaemia occurring after intensive combined modality treatment for IIIB Hodgkin ' s disease was transplanted from her HLA - identical brother . - pubmed
Tay - Sachs disease is an autosomal recessive genetic disorder resulting from mutation of the HEXA gene encoding the alpha - subunit of the lysosomal enzyme , beta - N - acetylhexosaminidase A ( ref . - pubmed
The thymus in " bare lymphocyte " syndrome : significance of expression of major histocompatibility complex antigens on thymic epithelial cells in intrathymic T - cell maturation . - pubmed
Thymic biopsies from two patients with combined immunodeficiency and defective expression of HLA class I and class II antigens on blood mononuclear cells ( " bare lymphocyte " syndrome ) were investigated . - pubmed
Growth inhibition of an MC - induced mouse sarcoma by TCGF ( IL 2)-containing preparations . - pubmed
Supernatants from Con A - stimulated rat spleen cell cultures containing T cell growth factor inhibited growth of a transplantable 3 - methylcholanthrene - induced sarcoma in syngeneic mice . - pubmed
The tumour - inhibitory effects were dependent on the concentration of T cell growth factor and repeated injections of the supernatants . - pubmed
The role of calcitonin and parathyroid hormone in the pathogenesis of post - thyroidectomy hypocalcemia . - pubmed
Though there was no significant depression of parathyroid hormone ( PTH ) levels , the failure of the parathyroids to respond to hypocalcemic stimuli suggests a degree of at least transient parathyroid insufficiency . - pubmed
Transiently elevated CT levels appear to play a significant role in the commonly observed early , transient post - thyroidectomy hypocalcemia following subtotal and total thyroidectomy . - pubmed
For all 3 HPT isolates , the expression of MT protein and mRNA for the MT-2A , MT-1E , MT-1F and MT-1 G isoforms was similar among the isolates and demonstrated no correlation to lethality . - pubmed
Initially , we detected the presence of MPS-1 mRNA by message amplification phenotyping in all condylomata tissues examined . - pubmed
We found that MPS-1 mRNA is expressed at high levels in the cytoplasm of condylomata cells . - pubmed
All were insulin - dependent diabetics . - pubmed
A control group was established from a pool of randomly selected , age - matched , insulin - dependent diabetics who were also observed for foot ulcerations . - pubmed
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone - related peptide gene . - pubmed
Mice homozygous for the PTHrP null mutation died postnatally , probably from asphyxia , and exhibited widespread abnormalities of endochondral bone development . - pubmed
These results provide direct evidence implicating PTHrP in normal skeletal development and serve to emphasize its potential involvement in human osteochondrodysplasias . - pubmed
Since leukemia cells of immature B - cell origin also synthesize IL-2R , the human pre - B cell leukemias could represent another type of hematological malignancy where the autocrine processes of IL-2 production and utilization are involved in the expansion of the disease . - pubmed
Monocyte chemoattractant protein-1 ( MCP-1 ) mediates monocyte migration into tissues in inflammatory diseases and atherosclerosis . - pubmed
Integrin alpha V beta 3 expression by bone - residing breast cancer metastases . - pubmed
The precise adhesion molecules involved in skeletal homing of breast cancer to bone are unknown but likely include integrins . - pubmed
We investigated the expression of vitronectin receptor ( alpha V beta 3 ) by breast cancer cells residing in bone because this heterodimer mediates osteoclast - bone recognition . - pubmed
We used immunohistochemistry and in situ hybridization in a systematic study of 22 bone biopsies containing breast cancer metastases and available samples of corresponding primary tumors and normal breast and compared alpha V beta 3 , alpha 2 beta 1 , and alpha B beta 5 integrin expression . - pubmed
The results showed that alpha V beta 3 was strongly expressed by normal breast epithelium and was decreased in some and strongly expressed in other primary invasive breast carcinomas . - pubmed
In contrast , this integrin heterodimer was abundant in all breast cancer cells metastatic to bone . - pubmed
In situ hybridization revealed high levels of steady - state mRNA corresponding to sites of protein expression ; alpha 2 beta 1 was weakly expressed in both primary and metastatic tumors , and alpha V beta 5 was not detected . - pubmed
Our results showed an overexpression of alpha V beta 3 by bone - residing breast cancer cells and suggest either subclonal selection of alpha V beta 3 - expressing tumor cell populations or upregulation of alpha V beta 3 in the bone microenvironment . - pubmed
[ Leptin ] in the post - absorptive state was examined in 67 subjects ( 26 male , 20 premenopausal female , 21 postmenopausal females ; 43 never - obese , 24 obese ) at usual body weight . - pubmed
Activity of the vitamin B12 - dependent enzyme , methylmalonyl CoA mutase , was measured in the tissues of pigs , fed a diet which was low in cobalt and vitamin B12 , and which were intermittently exposed to nitrous oxide until they displayed marked ataxia . - pubmed
The SRC , exclusively present in the CD4+CD8- fraction , is capable of multilineage repopulation of the bone marrow of nonobese diabetic mice with severe combined immunodeficiency disease ( NOD / SCID mice ) . - pubmed
To clarify the meaning and clinical value of bone formation markers in bone metastasis from prostate cancer , we investigated the bone formation markers carboxy - terminal propeptide of type I procollagen ( PICP ) , bone - specific alkaline phosphatase ( BA1 - p ) and osteocalcin , so - called bone gla protein ( BGP ) in 43 prostate cancer patients with and 46 patients without overt bone metastasis . - pubmed
The expression patterns of bone formation markers in patients with progression of bone metastasis became dissociated ; BA1 - p and PICP were elevated in patients with progression of bone metastasis but BGP was not . - pubmed
NLE is a rare condition which affects newborn infants from mothers who may me asymptomatic or have a connective tissue disease , with or without autoantibodies to extractable nuclear antigens Ro ( SS - A ) , LA ( SS - B ) or ribonucleoproteins . - pubmed
The K +- channel blocker tetraethylammonium ( TEA ) was applied to study its effects in self - sustaining , circling spreading depression in the chicken retina ( RSD ) . - pubmed
Six Group II goats had central medial meniscal tears repaired as in Group I plus an exogenous fibrin clot . - pubmed
Interleukin-4 and interleukin-5 as targets for the inhibition of eosinophilic inflammation and allergic airways hyperreactivity . - pubmed
Clinical and experimental investigations suggest that allergen - specific CD4 + T - cells , IgE and the cytokines IL-4 and IL-5 play central roles in initiating and sustaining an asthmatic response by regulating the recruitment and/or activation of airways mast cells and eosinophils . - pubmed
IL-5 plays a unique role in eosinophil development and activation and has been strongly implicated in the aetiology of asthma . - pubmed
Investigations in IL-5 -/- mice indicate that this cytokine is critical for regulating aeroallergen - induced eosinophilia , the onset of lung damage and airways hyperreactivity during allergic airways inflammation . - pubmed
While IL-4 and allergen - specific IgE play important roles in the regulation of allergic disease , recent investigations in IL-4-/- mice suggest that allergic airways inflammation can occur via pathways which operate independently of these molecules . - pubmed
Activation of these IL-4 independent pathways are also intimately associated with CD4 + T - cells , IL-5 signal transduction and eosinophilic inflammation . - pubmed
Such IL-5 regulated pathways may also play a substantive role in the aetiology of asthma . - pubmed
The central role of IL-5 in both components of allergic disease highlights the requirements for highly specific therapeutic agents which inhibit the production or action of this cytokine . - pubmed
Altered inotropic response to IGF - I in diabetic rat heart : influence of intracellular Ca2 + and NO . - pubmed
Normally , insulin - like growth factor I ( IGF - I ) exerts positive effects on cardiac growth and myocardial contractility , but resistance to its action has been reported in diabetes . - pubmed
This study was designed to determine whether IGF - I - induced myocardial contractile action is altered in diabetes as a result of an intrinsic alteration of contractile properties at the cellular level . - pubmed
Contractile responses to IGF - I were examined in left ventricular papillary muscles and ventricular myocytes from normal and short - term ( 5 - 7 days ) streptozotocin - induced diabetic rats . - pubmed
IGF - I ( 1 - 500 ng / ml ) caused a dose - dependent increase in PTD and PTA in preparations from normal but not diabetic animals . - pubmed
Pretreatment with the NO synthase inhibitor Nomega - nitro - L - arginine methyl ester ( 100 microM ) attenuated IGF - I - induced increases in PTD in normal myocardium but unmasked a positive inotropic action in diabetic animals . - pubmed
Consistent with its inotropic actions on muscles and myocytes , IGF - I induced a dose - dependent increase in Ca2 + transients in normal but not diabetic myocytes . - pubmed
These results suggest that the IGF - I - induced inotropic response is depressed in diabetes because of an intrinsic alteration at the myocyte level . - pubmed
Mechanisms underlying this alteration in IGF - I - induced myocardial response may be related to changes in intracellular Ca2 + and/or NO production in diabetes . - pubmed
While antibody - dependent cellular cytotoxicity against gp120 did not strongly differentiate the groups , slow progressors showed a broader neutralization pattern against 5 primary virus isolates . - pubmed
dHAND mutants exhibit hypoplasia of the right ventricle , branchial arches , and aortic arch arteries . - pubmed
The distinct nature of cardiac defects in dHAND mutants provides an entry into dissecting molecular pathways governing morphogenesis of specific components of the heart . - pubmed
Congenital heart disease is considered as a defect in segmental development of the heart and the role of dHAND and eHAND in regulating such developmental pathways in normal and abnormal cardiogenesis is examined . - pubmed
Recombinant human interleukin-11 is unlikely to stimulate the growth of the most common solid tumors . - pubmed
Recombinant human interleukin-11 ( rhIL-11 ) has been shown to enhance recovery from thrombocytopenia and mucosal injury after cancer chemotherapy . - pubmed
Since RNA for the receptor and signal transducer for IL-11 is detected in many cell types including some cancer cells , it was theoretically possible that rhIL-11 could affect the growth of tumor cells . - pubmed
This study was intended to determine whether rhIL-11 stimulates the proliferation of human tumor colony - forming units ( TCFUs ) taken directly from patients . - pubmed
Tumor cells were cultured in soft agar and continuously exposed to three concentrations of rhIL-11 ( 1.0 , 10.0 and 100.0 U / ml ) for 14 days in the capillary cloning system . - pubmed
These results suggest that rhIL-11 appears unlikely to stimulate the growth of the most common solid tumors . - pubmed
[ The effects of angiotensin II receptor antagonists on insulin resistance ] . - pubmed
We reviewed the effects of angiotensin II receptor antagonists on insulin resistant syndrome . - pubmed
Central nervous system - targeted expression of the complement inhibitor sCrry prevents experimental allergic encephalomyelitis . - pubmed
Here , we show that sCrry transgenic mice are either fully protected against EAE or develop significantly delayed clinical signs . - pubmed
Allele - specific loss or imbalance of chromosomes 9 , 15 , and 16 in B - cell tumors from interspecific F1 hybrid mice carrying Emu - c - myc or N - myc transgenes . - pubmed
Mice carrying an immunoglobulin enhancer ( Emu- ) linked c- or N - myc transgene develop fatal monoclonal or oligoclonal pre - B or B - cell lymphomas . - pubmed
This was done at 53 microsatellite markers in a panel of 34 lymphomas and four plasmacytomas from c - or N - myc transgene carrying ( BALB / c x Mus spretus)F1 hybrids . - pubmed
Staining of malignant mesothelioma for the trefoil protein pS2 . - pubmed
Increased fatty acid uptake and altered fatty acid metabolism in insulin - resistant muscle of obese Zucker rats . - pubmed
To determine whether FA uptake and disposal are altered in insulin - resistant muscle , we measured palmitate uptake , oxidation , and incorporation into di- and triglycerides in isolated rat hindquarters , as well as muscle plasma membrane fatty acid - binding protein ( FABP(PM ) ) content of lean ( n = 16 , fa/+ ) and obese ( n = 15 , fa / fa ) Zucker rats ( 12 weeks of age ) . - pubmed
Glucose uptake was 42 % lower in the obese than in the lean rats and indicated the presence of muscle insulin resistance . - pubmed
Fractional and total rates of palmitate uptake were 42 and 74 % higher in the obese than in the lean rats and were associated with higher muscle FABP(PM ) content ( r(2 ) = 0.69 , P & lt ; 0.05 ) . - pubmed
It was previously reported that silencing of the expression of glutamic acid decarboxylase ( GAD ) in transgenic nonobese diabetic ( NOD ) mice completely protected islet beta - cells against development of diabetes . - pubmed
The levels of total serum bilirubin ( P<0.05 ) and serum transaminases ( P<0.05 ) were significantly higher in patients with AIH - AH than in patients with AIH - CH and AIH - LC . - pubmed
However , the serum levels of gamma - globulin ( P<0.05 ) and immunoglobulin G ( P<0.05 ) were significantly lower in AIH - AH than in patients with AIH - CH and AIH - LC . - pubmed
Limited proteolysis as a post - translational modification will be discussed , focusing on the family of membrane protein secretases , in particular in relation to the Alzheimer 's amyloid precursor protein . - pubmed
Expression of frizzled - related protein and Wnt - signalling molecules in invasive human breast tumours . - pubmed
To explore the role of Frp and its relationship to the Wnt - signalling pathway in breast cancer , in situ hybridization and immunohistochemical analyses of Frp , Wnt-1 , APC , beta - catenin , and its target genes c - myc and cyclin D1 were conducted in 70 specimens of invasive ductal carcinomas of the human breast . - pubmed
Frp mRNA was down - regulated in 62 and elevated in eight tumour specimens , compared with adjacent normal tissues . - pubmed
In the course of tumour progression , however , Frp mRNA steadily increased in both tumour and the adjacent tissues . - pubmed
Interestingly , the number of cases with axillary lymph node metastasis was significantly lower in the group with elevated Frp than in the group with decreased Frp , suggesting that Frp may contribute as a prognostic factor in invasive breast cancer . - pubmed
Wnt-1 , a gene implicated in human breast cancer , was markedly elevated in grade 1 tumours , but declined as tumour grade declined . - pubmed
Beta - catenin , a key transcriptional activator responsible for the activation of both c - myc and cyclin D1 in colorectal tumours , was detected at high levels in the plasma membranes of cells in normal tissue . - pubmed
In tumour masses , however , beta - catenin lost its tight association with the membrane and diffused into the cytoplasm . - pubmed
Surprisingly , it clearly did not penetrate the nuclei , despite the fact that both c - myc and cyclin D1 were markedly elevated in all tumour tissues . - pubmed
As revealed in this study , Wnt-1 / beta - catenin plays very different roles in the oncogenesis of breast and colon cancers . - pubmed
This first systemic analysis of the Frp and the Wnt - signalling pathway in human breast cancer provides a springboard for further work on the role of Frp in the development of breast cancer . - pubmed
These results suggest that ET-1 at low concentration can protect the microsomal CCT activity and reduce the inhibition of PS lipid synthesis induced by oxidant lung injury . - pubmed
Impact of obesity and leptin levels on the secretion of estradiol , inhibin A and inhibin B during ovarian stimulation with gonadotropins . - pubmed
We examined the impact of high leptin levels on the secretion of estradiol , inhibin A and inhibin B in obese and lean women during ovarian stimulation . - pubmed
Obese women ( body mass index ( BMI ) & gt ; 28 kg / m(2 ) ; n = 17 ) were individually matched with lean women ( BMI 20 - 25 kg / m(2 ) ; n = 17 ) for age and baseline follicle stimulating hormone and luteinizing hormone concentrations . - pubmed
In the obese group , area - under - the - curve ( AUC ) leptin levels correlated with AUC inhibin A levels . - pubmed
Progressive age - related impairment of cognitive behavior in APP23 transgenic mice . - pubmed
In conclusion , APP23 mice exhibit both early behavioral impairment in the large Morris maze as well as impairments in passive avoidance and small pool performance that are marked only in old age . - pubmed
No patient with relapsed AML achieved CR , while it was achieved by five of eight patients with secondary AML at diagnosis ; five of six MDR1 + patients achieved CR . - pubmed
As concerns follow - up of the CR patients , one did not receive any further treatment and died in CR from pulmonary aspergillosis , and one with a concomitant chronic lymphocytic leukemia ( CLL ) received two courses of FLAG ( fludarabine , cytarabine , granulocyte colony - stimulating factor ) regimen with disappearance of the clonal Ig rearrangement , but relapsed after 11 months and died from pneumonia . - pubmed
Hemolytic disease of the newborn due to the rare blood factor , rhw(Cw ) . - pubmed
Effect of some glycosidase inhibitors on experimental tumours in the mouse . - pubmed
Histopathological study on the PTHrP - induced incisor lesions in rats . - pubmed
Parathyroid hormone related peptide ( PTHrP ) was discovered as a causative factor of humoral hypercalcemia of malignancy ( HHM ) . - pubmed
Nude rats were implanted with PTHrP - expressing tumor ( LC-6 ) cells , maintained for 12 weeks , after which the mandibular incisors were collected . - pubmed
These results suggest that hypercalcemia affected the entire calcification process resulting in hypercalcified dentin , and that high PTHrP concentrations affected selective populations of odontoblasts resulting in formation of dentin niche and thinning of dentin . - pubmed
The expression of the neuropeptide galanin is markedly up - regulated in many areas of the central and peripheral nervous system after injury . - pubmed
We have recently demonstrated that peripheral sensory neurons depend on galanin for neurite extension after injury , mediated by activation of the second galanin receptor subtype ( GALR2 ) . - pubmed
These results demonstrate that galanin acts an endogenous neuroprotective factor to the hippocampus and imply that a galanin agonist might have therapeutic uses in some forms of brain injury . - pubmed
The HER-2 - targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells . - pubmed
We explored combination effects of these agents in the HER-2 - overexpressing BT474 breast cancer cell line . - pubmed
These results suggest that combining HER-2 - targeting agents may be a more effective therapeutic strategy in breast cancer rather than treating with a single HER-2 monoclonal antibody . - pubmed
Polymorphisms of chemokine and chemokine receptor genes in Type 1 diabetes mellitus and its complications . - pubmed
Cytokines and chemokines have been implicated in the pathogenesis of Type 1 diabetes mellitus ( T1DM ) and its microvascular complications . - pubmed
The aim was to investigate whether genetic variants of the MCP-1 G(-2518)A , CCR2B 64I , CCR5 G(59029)A , and CCR5 Delta32 are associated with T1DM and its microvascular complications . - pubmed
Frequencies of the MCP-1 A(-2518 ) allele ( 74.6 % vs. 63.5 % , p & lt ; 0.003 ) and A / A genotype ( 54.5 % vs. 34.6 % , p & lt ; 0.001 , Pc = 0.002 ) were significantly higher in patients with T1DM compared with normal controls . - pubmed
CCR5 G(59029 ) was slightly increased in the patients with microvascular complications compared with the uncomplicated ( 21.4 % vs. 10 % , p & lt ; 0.03 , Pc = ns ) . - pubmed
These results suggest that polymorphisms of the MCP-1 , CCR2 and CCR5 genes may be associated with T1DM and its complications . - pubmed
TNF - alpha - transduced synoviocytes injected into the knee joints of severe combined immunodeficient ( SCID ) mice induced cell proliferation , as well as cartilage and bone erosion as soon as day 7 , creating a standardized , humanized animal model relevant for rheumatoid arthritis . - pubmed
For example , the ATP - binding cassette ( ABC ) drug transporters have been shown to protect cancer stem cells from chemotherapeutic agents . - pubmed
Targeting the c - Met pathway potentiates glioblastoma responses to gamma - radiation . - pubmed
EXPERIMENTAL DESIGN : Endogenous expression of SF / HGF and c - Met was targeted in U87 MG human malignant glioma cells and xenografts using chimeric U1 / ribozymes . - pubmed
RESULTS : U1 / ribozymes knocked down SF / HGF and c - Met mRNA and protein levels , sensitized cells to gamma - radiation ( P & lt ; 0.005 ) , and enhanced radiation - induced caspase - dependent cytotoxicity in vitro ( P & lt ; 0.005 ) . - pubmed
CONCLUSIONS : Targeting the SF / HGF / c - Met pathway markedly potentiates the anti - glioma response to gamma - radiation . - pubmed
Clinical trials using novel SF / HGF / c - Met pathway inhibitors in glioma and other malignancies associated with c - Met activation should ultimate include concurrent radiation and potentially other cytotoxic therapeutics . - pubmed
Seventeen ( 70.8 % ) of the 24 melanomas showed a copy number loss of either the CDKN2A or CDKN2B gene on chromosome 9p21 . - pubmed
BACKGROUND : Inflammation is a predominant characteristic of autoimmune diseases which is characterized by the increased expression of pro - inflammatory cytokines . - pubmed
The current paper attempts to illustrate how Perna can alleviate inflammation by modulating inflammatory cytokines , cyclooxygenase enzymes and Immunoglobulin - G ( IgG ) levels . - pubmed
CONCLUSION : We have successfully demonstrated modulation in the levels of inflammatory cytokines , cyclooxygenase enzymes and immunoglobulins by our in - house laboratory preparations of Perna canaliculus , whereby suggesting an immunomodulatory role of Perna canaliculus in regulating inflammation . - pubmed
DESIGN : Prior to initiating anemia control interventions , schoolgirls in early adolescence were studied with regard to their hemoglobin status , physical work capacity and cognitive functions . - pubmed
RESULTS : The mean hemoglobin was 11.32 g / dL , and anemia prevalence : 67 % . - pubmed
TGF - beta in cancer and as a therapeutic target . - pubmed
Transforming growth factor - beta which is a growth suppressive cytokine in many normal situations becomes an active and important participant in malignant disease including angiogenesis , extracellular matrix deposition , immuno - suppression and metastasis growth promotion . - pubmed
Tumor - suspect nodules previously considered disease free by HE stain on whole - mount section were examined by in situ hybridization ( ISH ) on tissue microarray ( TMA ) through detecting mRNAs of CEA and CK20 with non radioactive biotin - tagged oligonucleotide probes . - pubmed
Thus , management of iNOS expression or activity prior to intestinal surgery protects against postsurgical dysmotility and reduces the severity of postoperative ileus . - pubmed
Downregulation of c - FLIP promotes caspase - dependent JNK activation and reactive oxygen species accumulation in tumor cells . - pubmed
To suppress this antiapoptotic function of NF - kappaB might be a promising strategy to increase susceptibility of tumor cells to stress - induced cell death . - pubmed
To apply this observation to tumor therapy , we knocked down c - FLIP by RNA interference in various tumor cells . - pubmed
Consistent with the results using c - Flip(-/- ) MEFs , we found that TNFalpha stimulation induced caspase - dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . - pubmed
Given that ROS accumulation and necrotic cell death enhance inflammation followed by compensatory proliferation of tumor cells , selective suppression of caspase - dependent ROS accumulation will be an alternative strategy to protect cells from ROS - dependent DNA damage and compensatory tumor progression . - pubmed
Using an excisional wound splinting model , we showed that injection around the wound and application to the wound bed of green fluorescence protein ( GFP)(+ ) allogeneic BM - MSCs significantly enhanced wound healing in normal and diabetic mice compared with that of allogeneic neonatal dermal fibroblasts or vehicle control medium . - pubmed
We show that attenuation of Cx43 - mediated communication by a Cx mimetic peptide enhanced wound closure rates in keratinocyte monocultures and in the living skin equivalent system , emphasising the utility of the model to systematically unravel the molecular mechanisms underlying epidermal morphogenesis , assess promising therapeutic strategies , and reduce animal experimentation . - pubmed
Here we investigated whether the dysfunction of the ubiquitin proteasome system might be involved in the pathogenesis and regional selectivity of neuronal ubiquitinated inclusions using the SAMP10 strain of mouse , an inbred model of age - related cerebral degeneration . - pubmed
Prophylaxis with rhGM - CSF was associated with significantly fewer life - threatening and serious ( grade & gt ; or =3 ) infections , especially in older patients undergoing treatment for AML . - pubmed
The limited experience with rhGM - CSF for the treatment of invasive fungal infections in combination with antifungal drug(s ) was associated with a favorable outcome , and in contrast to Escherichia coli - derived rhGM - CSF , the new preparation ( sargramostim ) was well tolerated and rarely associated with serious systemic toxicities . - pubmed
Similarly , IFN - gamma has been successfully used in patients with antimicrobial drug - refractory and/or disseminated fungal infection . - pubmed
In difficult - to - treat fungal infections , the addition of cytokines appears to improve outcome and may be considered early in severely immunosuppressed patients with AML . - pubmed
In this prospective randomized study , we investigated the effect of raloxifene on the echocardiographic parameters of left ventricular diastolic and systolic function and on blood levels of lipids , homocysteine , and lipoprotein ( a ) in postmenopausal osteoporotic patients and compared the results with those treated with risedronate . - pubmed
Expression of gamma - H2AX in melanocytic lesions . - pubmed
gamma - H2AX is a marker of activated DNA damage and is overexpressed in many malignancies and their precursor lesions . - pubmed
Previous studies have demonstrated the expression of gamma - H2AX in melanoma and dysplastic nevus , but its diagnostic and prognostic utility in a full range of melanocytic lesions has not been fully studied . - pubmed
In the current study , we investigated gamma - H2AX expression in a total of 162 melanocytic lesions . - pubmed
We found that gamma - H2AX was observed at higher levels ( percentage and intensity of staining ) in melanoma in situ ( 12/13 ) , primary cutaneous melanoma ( 32/33 ; with the exception of desmoplastic melanoma ) , and metastatic melanoma ( 58/62 ) , which was statistically different from that in benign nevus ( 7/9 ) , dysplastic nevus ( 6/10 ) , and Spitz nevus ( 5/9 ) considered together ( P & lt ; .0001 ) . - pubmed
Of note , desmoplastic melanoma ( 20/26 ) demonstrated weak or negative gamma - H2AX staining . - pubmed
The expression of gamma - H2AX did not show significant correlation with many melanoma prognostic factors , including Breslow depth , mitotic rate , and sentinel lymph node status . - pubmed
Except for desmoplastic melanoma , no difference in gamma - H2AX levels was observed among various melanoma subtypes . - pubmed
The overexpression of gamma - H2AX in melanoma as opposed to nevus indicates its possible role in melanomagenesis . - pubmed
DIAGNOSIS / TESTING : CMT1A ( 70%-80 % of all CMT1 ) involves duplication of PMP22 . - pubmed
CMT2E/1F ( & lt;5 % of all CMT1 ) is associated with pathogenic variants in NEFL . - pubmed
GENETIC COUNSELING : CMT1 is inherited in an autosomal dominant manner . - pubmed
About two thirds of probands with CMT1A have inherited the PMP22 duplication ; about one third have CMT1A as the result of a de novo pathogenic variant . - pubmed
[ Effects of differentially expressed proteins in hepatocellular carcinoma cell treated by different telomerase inhibitors ] . - pubmed
OBJECTIVE : To detect differentially expressed proteins in hepatocellular carcinoma cell line SMMC-7721 treated separately by eight telomerase inhibitors including antisense oligodeoxynuclectide of human telomerase RNA ( hTR - ASODN ) , sense oligodeoxynuclectide of hTR ( hTR - SODN ) , ASODN of human telomerase reverse transcriptase ( hTERT - ASODN ) , SODN of hTERT ( hTERT - SODN ) , epigallocatechin gallate ( EGCG ) , 3 '- azido-3 '- deoxythymidine ( AZT ) , all trans - retinoic acid ( ATRA ) and adriamycin ( ADM ) using surface enhanced laser desorption / ionization time of flight - mass spectrom ( SELDI - TOF - MS ) technology . - pubmed
On 23 October 2009 , the commissioner of the US Food and Drug Administration ( FDA ) issued an Emergency Use Authorization ( EUA ) for peramivir for intravenous injection , an unapproved neuraminidase inhibitor used for treating certain hospitalized adult and pediatric patients infected with 2009 H1N1 influenza . - pubmed
During the course of heparin - induced extracorporeal lipoprotein apheresis , a patient with no prior known renal impairment or proteinuria demonstrated sustained improvement in estimated glomerular filtration rate , commensurate with reduction in serum lipids and creatine phosphokinase levels . - pubmed
DNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas . - pubmed
RRP22 ( Ras - related protein on chromosome 22 ) has been suggested as a candidate tumor suppressor in human cancers . - pubmed
Investigating a panel of 70 human gliomas , we found a frequent decrease in the RRP22 mRNA expression levels ( 67 % ) , preferentially in high - grade gliomas [ World Health Organization ( WHO ) grades III and IV ] as compared with low - grade gliomas ( WHO grade II ) . - pubmed
Moreover , reduced RRP22 mRNA expression was associated with shorter overall survival in 180 glioblastoma patients included in the National Institutes of Health Repository for Molecular Brain Neoplasia Data ( NIH REMBRANDT ) database . - pubmed
Decreased RRP22 expression levels were in part explained by 5'-CpG island hypermethylation and increased by the treatment with the demethylating agent 5 - aza-2 '- deoxycytidine in glioblastoma cell lines . - pubmed
Moreover , in primary human glioblastomas , we observed an increase of H3K9me3 - bound and a decrease of pan - Ac - H3 - bound RRP22 in comparison with non - neoplastic brain tissue , consistent with a heterochromatinization of the RRP22 promoter . - pubmed
Taken together , our findings demonstrate that both 5'-CpG island hypermethylation and histone modifications contribute to the frequent and prognostically unfavorable transcriptional downregulation of RRP22 in malignant gliomas . - pubmed
[ Expression of beta - endorphin in hypertrophic scar and its relationship with pruritus ] . - pubmed
OBJECTIVE : To identify the effect of beta - endorphin in the development of paresthesia in hypertrophic scar by detecting the expression and content of beta - endorphin in human normal skin and hypertrophic scar . - pubmed
RESULTS : The beta - endorphin expressed in all samples , and it expressed around peripheral nerve fibers in the dermis , fibroblasts , and monocytoid cells principally ; and it expressed significantly stronger in pruritus group and pain - pruritus group than in non - pain - pruritus group and normal skin group . - pubmed
The beta - endorphin content was ( 617.401 + /- 97.518 ) pg / mL in non - pain - pruritus group , ( 739.543 + /- 94.149 ) pg / mL in pruritus group , ( 623.294 + /- 149.613 ) pg / mL in pain - pruritus group , and ( 319.734 + /- 85.301 ) pg / mL in normal skin group ; it was significantly higher in non - pain - pruritus group , pruritus group , and pain - pruritus group than in normal skin group ( P & lt ; 0.05 ) ; it was significantly higher in pruritus group than in non - pain - pruritus group and pain - pruritus group ( P & lt ; 0.05 ) ; and there was no significant difference between non - pain - pruritus group and pain - pruritus group ( P & gt ; 0.05 ) . - pubmed
CONCLUSION : The expression of beta - endorphin is high in hypertrophic scar , it may play an important role in process of pruritus in these patients . - pubmed
In Parkinson ' s disease , while D2 / 3 dopamine agonists alleviate motor symptoms , behavioral addictions and withdrawal syndrome are reported in up to 15 % of patients . - pubmed
We evaluated the reinforcing properties of the widely used D2 / 3 agonist , Pramipexole ( PPX ) , in normal and parkinsonian rats . - pubmed
Within 2 h of injection , SE induced selective transcription of TLR2 and MyD88 in the liver , and increased systemic production of plasma IL-6 and TNF - alpha . - pubmed
Measurements of lung function ( compliance and resistance ) , development ( morphometry ) , inflammation ( histology ; multiplex analysis of bronchoalveolar lavage fluid for cytokines ; PCR array and multiplex analysis of lung homogenates for cytokines ) was performed on postnatal day 14 . - pubmed
Elucidation of the crystal structure will provide insights into the interactions of Spy0843 with the gp340 receptor and a better understanding of the role of Spy0843 in streptococcal infections . - pubmed
Human mitochondrial voltage - dependent anion channel 2 ( hVDAC-2 ) , the most predominant isoform seen in brain mitochondria , is not only crucial for cell survival but is also implicated in Alzheimer disease . - pubmed
Prostate cancer : PSA enzymatic activity to assess disease aggressiveness . - pubmed
Ustekinumab , an anti - IL-12 / 23 p40 monoclonal antibody , inhibits radiographic progression in patients with active psoriatic arthritis : results of an integrated analysis of radiographic data from the phase 3 , multicentre , randomised , double - blind , placebo - controlled PSUMMIT-1 and PSUMMIT-2 trials . - pubmed
OBJECTIVE : Evaluate ustekinumab , an anti - interleukin ( IL )- 12 and IL-23 antibody , effects on radiographic progression in psoriatic arthritis ( PsA ) . - pubmed
Patients had active PsA despite prior conventional and/or biologic disease - modifying antirheumatic drugs ( & gt;=5/66 swollen , & gt;=5/68 tender joints , C - reactive protein & gt;=3.0 mg / L , documented plaque psoriasis ) . - pubmed
Defective adipose tissue development associated with hepatomegaly in cathepsin E - deficient mice fed a high - fat diet . - pubmed
In this study , we investigated the characteristics of cathepsin E - deficient ( CatE(-/- ) ) mice fed a high - fat diet ( HFD ) , as a mouse model of obesity . - pubmed
Thus , the impaired adipose tissue development in HFD - induced CatE(-/- ) mice was probably due to reduced infiltration of macrophages and may lead to hepatomegaly accompanied by hepatic steatosis and hypercholesterolemia . - pubmed
Barriers to initiating insulin in type 2 diabetes patients : development of a new patient education tool to address myths , misconceptions and clinical realities . - pubmed
PURPOSE : The purpose of this study was to identify patient beliefs as well as clinical realities about insulin that may be barriers to type 2 diabetes patients initiating insulin treatment when recommended by their physician . - pubmed
METHODS : Thirteen focus groups were conducted in five countries ( Germany , Sweden , The Netherlands , UK , and USA ) to collect qualitative data on attitudes about insulin therapy from type 2 diabetes patients aged 18 or older whose physician had recommended initiating insulin treatment in the past 6 months ( n = 87 ) . - pubmed
CONCLUSIONS : Patient misconceptions , as well as some clinical realities , about insulin treatment and diabetes can influence the decision to initiate insulin treatment and ultimately impact disease management . - pubmed
Efficacy of some non - conventional herbal medications ( sulforaphane , tanshinone IIA , and tetramethylpyrazine ) in inducing neuroprotection in comparison with interleukin-10 after spinal cord injury : A meta - analysis . - pubmed
OBJECTIVES : To assess the efficacy of some non - conventional herbal medications including sulforaphane , tanshinone IIA , and tetramethylpyrazine in reducing inflammation and compare them with a known effective anti - inflammatory agent ( interleukin-10 ( IL-10 ) ) . - pubmed
CONCLUSION : IL-10 has a strong effect in the induction of neuroprotection and neurorecovery after SCI by multiple pathways . - pubmed
Tetramethylpyrazine has an acceptable influence in reducing inflammation through the up - regulation of IL-10 . - pubmed
Analysis of the trajectory of osteoarthritis development in a mouse model by serial near - infrared fluorescence imaging of matrix metalloproteinase activities . - pubmed
It is hypothesized that proteases , such as matrix metalloproteinases ( MMPs ) , are up - regulated in the early stages of OA development . - pubmed
This study was undertaken to investigate if a near - infrared ( NIR ) fluorescent probe activated by MMPs could visualize in vivo OA progression beginning in the early stages of the disease . - pubmed
MMP activity was then evaluated in vivo serially in a mouse model of chronic , injury - induced OA . - pubmed
CONCLUSION : Imaging of MMP activity in a mouse model of OA provides sensitive and consistent visualization of OA progression , beginning in the early stages of OA . - pubmed
Pemetrexed Singlet Versus Nonpemetrexed - Based Platinum Doublet as Second - Line Chemotherapy after First - Line Epidermal Growth Factor Receptor ( EGFR ) Tyrosine Kinase Inhibitor Failure in Non - small Cell Lung Cancer Patients with EGFR Mutations . - pubmed
PURPOSE : Platinum - based doublet chemotherapy is the treatment of choice for patients with non - small cell lung cancer ( NSCLC ) ; however , the role of a platinum - based doublet as second - line therapy after failure of an epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitor ( TKI ) for NSCLC patients has not yet been elucidated . - pubmed
The purpose of this study was to compare the clinical efficacy of pemetrexed versus a platinum - based doublet as second - line therapy after failure of EGFR TKI used as first - line therapy for NSCLC patients with EGFR mutations . - pubmed
MATERIALS AND METHODS : We designed a multicenter retrospective cohort study of 314 NSCLC patients with EGFR mutations who received an EGFR TKI as first - line palliative chemotherapy . - pubmed
CONCLUSION : Our retrospective analysis found that second - line pemetrexed singlet therapy provided significantly prolonged PFS compared to second - line platinum - based doublet chemotherapy for NSCLC patients with EGFR mutations who failed first - line EGFR TKI . - pubmed
Increased cell adhesion , alpha - smooth muscle actin ( alpha - SMA ) expression and increased extracellular matrix deposition are a hallmark of fibrotic cells , but how topographic features influence gingival fibroblast adhesion and adoption of the alpha - SMA positive myofibroblast phenotype associated with scarring is unknown . - pubmed
Mannose - binding lectin gene polymorphism and chronic hepatitis B infection in children . - pubmed
In this study , the relation between MBL gene polymorphism and chronic hepatitis B infection in children is evaluated . - pubmed
RESULTS : Homozygous codon 54 polymorphism of MBL was found significantly higher in chronic hepatitis B patients than controls . - pubmed
CONCLUSIONS : The hepatitis B patients who are homozygous for codon 54 of MBL are prone to develop chronic infection . - pubmed
Strong staining of fibronectin and p - CREB was detected in kidney cortex of db / db mice while treated mice with rapamycin reversed hyperglycemia effect . - pubmed
In summary , our data provide a novel mechanism of transcriptional regulation of fibronectin through CREB that may be used as therapeutic approach to prevent diabetes complications . - pubmed
Correct diagnosis of HIT followed by therapy based on histamine - free diet and supplementation of diamine oxidase can improve patient 's quality of life . - pubmed
HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF - beta pathways . - pubmed
Homeobox ( HOX ) genes , including HOXA13 , are involved in human cancer . - pubmed
We found that HOXA13 expression was associated with glioma grade and prognosis . - pubmed
Bioinformatics analysis revealed that most of the HOXA13 - associated genes were enriched in cancer - related signaling pathways and mainly involved in the regulation of transcription . - pubmed
We transfected four glioma cell lines with Lenti - si HOXA13 . - pubmed
Furthermore , downregulation of HOXA13 in orthotopic tumors decreased tumor growth . - pubmed
We suggest that HOXA13 promotes glioma progression in part via Wnt- and TGF - beta - induced EMT and is a potential diagnostic biomarker for glioblastoma and an independent prognostic factor in high - grade glioma . - pubmed
IL-37 mediates the antitumor activity in renal cell carcinoma . - pubmed
The aim of this study was to investigate the role of IL-37 in renal cell carcinoma ( Rcc ) . - pubmed
The expression of IL-37 was decreased in Rcc patients and was negatively correlated with tumor progression . - pubmed
In vivo , tumor growth and gene expressions of IL-6 and HIF-1alpha were suppressed by IL-37 . - pubmed
TGF - beta1 prevents rat retinal insult induced by amyloid - beta ( 1 - 42 ) oligomers . - pubmed
To set up a retinal degenerative model in rat that mimics pathologic conditions such as age - related macular degeneration ( AMD ) using amyloid - beta ( Abeta ) oligomers , and assess the effect of TGF - beta1 . - pubmed
Bioinformatic analysis revealed that Bcl-2 and PI3K - Akt are the most connected nodes , for genes and pathways respectively , in the enriched gene - pathway network common to AMD and Alzheimer disease ( AD ) . - pubmed
Overall , these data indicate that ITV injection of Abeta1 - 42 oligomers in rat induces molecular changes associated with apoptosis in rat retina , highlighting a potential pathogenetic role of Abeta oligomers in AMD . - pubmed
Furthermore , these findings suggest that human recombinant TGF - beta1 can prevent retinal damage elicited by Abeta oligomers . - pubmed
The Interaction of UDP - N - Acetylglucosamine 2 - Epimerase / N - Acetylmannosamine Kinase ( GNE ) and Alpha - Actinin 2 Is Altered in GNE Myopathy M743 T Mutant . - pubmed
UDP - N - acetylglucosamine 2 - epimerase / N - acetylmannosamine kinase ( GNE ) is the gene mutated in GNE myopathy . - pubmed
Further , GNE carrying the M743 T mutation , the most frequent mutation in GNE myopathy , has a 10 - fold lower binding affinity to alpha - actinin 2 than intact GNE . - pubmed
Lack of Association between NYD - SP18 Variant and Obesity . - pubmed
CONCLUSION : This study in a large Slavonic population sample suggests that the rs6971091 variant within the NYD - SP18 gene is not an important determinant of obesity in middle - aged persons . - pubmed
Vascular endothelial growth factor ( VEGF)-neutralizing proteins provide benefit in several retinal and choroidal vascular diseases , but some patients still experience suboptimal outcomes , and the need for frequent intraocular injections is a barrier to good outcomes . - pubmed
A mimetic peptide derived from collagen IV , AXT107 , suppressed subretinal neovascularization ( NV ) in two mouse models predictive of effects in neovascular age - related macular degeneration ( NVAMD ) and inhibited retinal NV in a model predictive of effects in ischemic retinopathies . - pubmed
AXT107 reduced the VEGF - induced vascular leakage that underlies macular edema in ischemic retinopathies and NVAMD . - pubmed
In rabbit eyes , which are closer to the size of human eyes , intraocular injection of AXT107 significantly reduced VEGF - induced vascular leakage by 86 % at 1 month and 70 % at 2 months ; aflibercept significantly reduced leakage by 69 % at 1 month and did not reduce leakage at 2 months , demonstrating the longer effectiveness of AXT107 . - pubmed
In the present study we evaluated the effect of the dopamine D1 - and D2 - like receptor antagonists ( SCH23390 and raclopride , respectively ) on the short - time effects of acute social defeat ( ASD ) . - pubmed
Mice exposed to ASD showed an increase in reinstatement of the conditioned reinforcing effects of cocaine that was blocked by all of the dopamine receptor antagonists . - pubmed
The dopamine D1 receptor is clearly involved in the rewarding effects of cocaine , but its role in the effects of ASD remains to be demonstrated . - pubmed
The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal - induced acute gouty arthritis in mice . - pubmed
Tyrosine kinase inhibitors have demonstrated therapeutic benefit in experimental models of antibody - dependent arthritis and in rheumatoid arthritis in humans , but to date , the potential effects of such inhibitors on gouty arthritis has not been evaluated . - pubmed
Here we demonstrate that treatment with the tyrosine kinase inhibitor imatinib mesylate ( imatinib ) can suppress inflammation induced by injection of MSU crystals into subcutaneous air pouches or into the ankle joint of wild type mice . - pubmed
Moreover , imatinib treatment also largely abolished the lower levels of inflammation which developed in IL-1R1-/- or KitW - sh / W - sh mice , indicating that this drug can inhibit IL-1 - independent pathways , as well as mast cell - independent pathways , contributing to pathology in this model . - pubmed
Altogether , these results raise the possibility that tyrosine kinase inhibitors might have utility in the treatment of acute gout in humans . - pubmed
More valuable information could probably be provided about the variety of the diseases caused by superoxide anions toxicities by intervention and application of the non - viral method for expressions of SOD1 and SOD3 enzymes . - pubmed
Of note , CD96 expression was highly correlated with T - cell markers in primary and metastatic human tumors and was elevated on antigen - experienced T cells and tumor - infiltrating lymphocytes . - pubmed
Collectively , these data demonstrate that CD96 may be a promising immune checkpoint to enhance T - cell function against human cancer and infectious disease . - pubmed
In summary , the structural elucidation of opioid receptors , allosteric modulation of opioid receptors , new opioid modulators and agonists , the employment of optogenetics , optopharmacology , and next - generation sequencing of opioid receptor genes and related functionality should create exciting new avenues for research and therapeutic development to treat conditions including pain , opioid abuse , and addiction . - pubmed
INTRODUCTION : During the last decade , new FVIII / IX concentrates have been developed for the treatment of patients affected by hemophilia A / B. - pubmed
The new humanized monoclonal antibody ( MAb ) ACE910 , mimicking FVIII function , seems to be able to reduce the bleedings of hemophilia A patients with inhibitors . - pubmed
We aimed to determine the occurrence of IgG4 - retroperitoneal fibrosis ( IgG4 - RPF ) in a nationwide study on patients with newly diagnosed IRPF , and to compare histopathological , imaging , and clinical features in the IgG4 - RPF and non - IgG4 - RPF subsets . - pubmed
Nineteen ( 45 % ) met the criteria for IgG4 - RPF , seven with definite and 12 with possible IgG4 - RPF , while 23 had non - IgG4 - RPF . - pubmed
Arterial hypertension ( p = 0.037 ) and periaortic fibrosis ( p = 0.024 ) were more common in IgG4 - RPF vs non - IgG4 - RPF . - pubmed
There was a positive correlation between tissue IgG4 - positive plasma cells and eosinophil cell count in patients with IgG4 - RPF ( rho = 0.50 , p = 0.043 ) . - pubmed
Conclusion : Forty - five per cent of this nationwide study population with newly diagnosed IRPF could be reclassified with IgG4 - RPF . - pubmed
The association between high numbers of IgG4 - bearing plasma cells and histopathological features of IgG4 - RPF supports IgG4 - bearing plasma cells with a perturbed distribution between IgG4 and total IgG being implicated in the pathogenesis of IgG4 - RPF . - pubmed
SOX11 hypermethylation as a tumor biomarker in endometrial cancer . - pubmed
We previously reported that SOX4 is overexpressed in endometrial cancer and that it partially contributes to hypermethylation of miR-129 - 2 and miR-203 . - pubmed
The methylation level of the SOX11 locus was correlated with clinicopathologic factors in primary endometrial tumors and in TCGA endometrial cohort . - pubmed
COBRA assays indicated that hypermethylation of SOX1 , SOX2 , SOX11 , SOX14 , SOX15 , SOX17 , and SOX18 was present in endometrial cancer cell lines and not in the normal control . - pubmed
Moreover , aberrant DNA methylation of SOX11 was detected in the majority of endometrioid endometrial carcinomas ( n=114 ) and none of the 22 adjacent normal endometrial samples ( P<0.0001 ) . - pubmed
The methylation status of SOX11 associated significantly with microsatellite instability and MLH1 methylation in endometrial tumors ( P<0.0001 ) , and this finding was validated in TCGA endometrial cohort . - pubmed
Furthermore , SOX11 was not hypermethylated in serum DNA from early stage endometrial cancer patients . - pubmed
This study found that hypermethylation of SOX11 is common in endometrial carcinomas and strongly associates with microsatellite instability and MLH1 methylation . - pubmed
Carrying a 112 bp - segment in Helicobacter pylori dupA may associate with increased risk of duodenal ulcer . - pubmed
Among different investigated virulence factors , duodenal ulcer promoting gene A ( dupA ) has been found to be associated with duodenal ulcer ( DU ) , but its effect was different in various geographical regions . - pubmed
pylori dupA may serve as the first detected biomarker for the early detection of DU in patients admitted to hospitals . - pubmed
KRAS alterations were present in 30 % of polyps . - pubmed
The Ras - like GTPases RalA and RalB act downstream of Ras in malignant peripheral nerve sheath tumors . - pubmed
Non - targeted and targeted metabolomics were applied on both lean ss - Phb2-/- mice ( ss - cell - specific prohibitin-2 knockout ) and obese db / db mice ( leptin receptor mutant ) , two distinct mouse models requiring neither chemical nor diet treatments to induce spontaneous decline of functional ss - cell mass promoting progressive diabetes development . - pubmed
Unraveling FATP1 , regulated by ER - beta , as a targeted breast cancer innovative therapy . - pubmed
Recently , our team has shown that FATP1 has a pivotal role in FA transfer between breast cancer cells ( BCCs ) and non - cancerous cells in the microenvironment . - pubmed
We aimed to investigate the role of FATP1 in BCCs and also to explore if FATP1 inhibition is a promising therapeutic strategy . - pubmed
In patients ' data , we showed a higher expression of FATP1 / SLC27A1 in TNBC , which correlated with a significant decreased overall survival ( OS ) . - pubmed
In vitro , we verified that FA and estradiol stimulated FATP1 / SLC27A1 expression in BCCs . - pubmed
Additionally , experiments with estradiol and PHTPP ( ER - beta antagonist ) showed that estrogen receptor - beta ( ER - beta ) regulates FATP1 / SLC27A1 expression , the uptake of FA and cell viability , in four BCC lines . - pubmed
Our study , unraveled FATP1 as a putative therapeutic target in breast cancer ( BC ) . - pubmed
Efficacy of xanthine oxidase inhibitor for chronic kidney disease patients with hyperuricemia . - pubmed
CONCLUSIONS : In this study , XO inhibitors did not significantly reduce the uPCR in chronic kidney disease stage 3 and 4 patients with hyperuricemia . - pubmed
BACKGROUND : Fingolimod ( FTY ) applied as treatment regimen of relapsing - remitting multiple sclerosis ( RRMS ) induces downregulation of sphingosine-1 - phosphate receptors on the lymphocytes . - pubmed
As a result CC chemokine receptor type 7 ( CCR7 ) expressing lymphocytes are retained within the peripheral lymph nodes thus suppressing their accumulation into the cerebrospinal fluid of multiple sclerosis ( MS ) patients and hampering disease progress . - pubmed
Unfortunately , MS patients treated with FTY suffer from an increased incidence of varicella - zoster virus ( VZV ) infections which has been associated with a decrease of VZV immediate early 63 ( IE63)-specific T - cell immunity . - pubmed
Additionally , a strong correlation between VZV - specific IgG serum titers and the percentage of RRMS patients with detectable VZV - specific T cells was observed ( r = 0.985 ) . - pubmed
Most remarkably , FTY - treated RRMS patients presented a shift in the predominant CD8 + T cell - mediated antigen - response from immediate early ( IE62 ) to early virus antigens ( ORF26 ) six months after treatment in parallel to a decrease of VZV - specific CD4 + T - cell immunity . - pubmed
ORF26 - specific CD8 + T cells still dominated the VZV - specific cellular immunity at month 12 after FTY - treatment start and in LT FTY - treated MS patients . - pubmed
In a RRMS patient an increase of VZV - specific CD4 + T cells at VZV - reactivation accompanied with a four - fold increase of a VZV - specific IgG titer was detected which might indicate an important role in cellular immune control of VZV - infections . - pubmed
Hereby , we report a 71 - year - old female with seronegative rheumatoid arthritis who presented with massive splenomegaly , pancytopenia , and positivization of antibodies against double - stranded deoxyribonucleic acid ( dsDNA ) after initiation of the anti - tumor necrosis factor ( TNF ) golimumab . - pubmed
EBV - associated LPDs are described after initiation of other anti - TNF agents , such as infliximab , but no reports of golimumab - associated EBV LPD are found in the literature . - pubmed
Urethral meatus stricture BOO stimulates bladder smooth muscle cell proliferation and pyroptosis via IL-1beta and the SGK1 - NFAT2 signaling pathway . - pubmed
Compared with chronic obstruction , acute obstruction led to increased expression of proliferating cell nuclear antigen and interleukin-1beta , which are markers of proliferation and inflammation , respectively . - pubmed
RESULTS : In the presence of tPA , 28 - day TP inhibited tPA - induced coagulopathy as effectively as WB . - pubmed
Efficacy of Pembrolizumab Monotherapy in Patients With or Without Brain Metastases From Advanced Non - Small Cell Lung Cancer With a PD - L1 Expression > = 50 . - pubmed
The authors conducted a multicenter retrospective study on the outcome of programmed death - ligand 1 tumor proportion score>=50 % advanced non - small cell lung cancer patients treated with first - line pembrolizumab according to the presence / absence of brain metastases . - pubmed
Pembrolizumab has activity against brain metastases from non - small cell lung cancers with programmed death - ligand 1>=50 % . - pubmed
ATP - Sensitive Potassium Channels Mediate the Cardioprotective Effect of Panax notoginseng Saponins against Myocardial Ischaemia - Reperfusion Injury and Inflammatory Reaction . - pubmed
Human Diversity of Killer Cell Immunoglobulin - Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes . - pubmed
We investigated the genetic profiles of killer cell immunoglobulin - like receptors ( KIRs ) in Ebola virus - infected patients . - pubmed
We studied the relationship between KIR - human leukocyte antigen ( HLA ) combinations and the clinical outcomes of patients with Ebola virus disease ( EVD ) . - pubmed
We genotyped KIRs and HLA class I alleles using DNA from uninfected controls , EVD survivors , and persons who died of EVD . - pubmed
The activating 2DS4 - 003 and inhibitory 2DL5 genes were significantly more common among persons who died of EVD ; 2DL2 was more common among survivors . - pubmed
Our findings highlight the importance of innate immune response against Ebola virus and show the association between KIRs and the clinical outcome of EVD . - pubmed
Relation of insulin receptors to insulin resistance . - pubmed
Utilizing large adipocytes from adult rats and small fat cells from young rats , we have conducted a series of in vitro experiments in an attempt to determine the cellular alteration(s ) responsible for the insulin resistance associated with obesity . - pubmed
It has been proposed that altered insulin - receptor interaction underlies the insulin resistance of human obesity . - pubmed
Thus , the initial step in insulin action is unaltered in human obesity . - pubmed
Virus isolation and determination of serum transaminase activity in 237 patients under one year of age were undertaken to clarify the etiologic significance of primary infection with cytomegalovirus ( CMV ) in infancy . - pubmed
In contrast , CMV was recovered from 14 % ( 18/127 ) and 13 % ( 18/141 ) of infants with normal S - GOT and S - GPT values . - pubmed
Correlation between complement - fixing antibody and liver involvement , however , was not significant , probably because of the influence by maternal antibody . - pubmed
The examination of the presence of Ph chromosome and of the fused gene BCR - ABL in patients with chronic myeloid leukemia ( CML ) is significant for the precise diagnosis and in some cases for the prognosis of the disease . - pubmed
We examined peripheral blood for the presence of BCR - ABL fused gene by polymerase chain reaction ( PCR ) in eight patients with CML consecutively cytogenetically studied before and after the bone marrow transplantation and in two patients treated with interferon . - pubmed
After 2 weeks , the fish were exposed to severe environmental hypoxia ( final water oxygen partial pressure , PWO2 = 25 - 45 Torr , reached within 20 min ) , to assess the impact of the experimentally induced alkalosis , and hence increased haemoglobin - oxygen ( Hb - O2 ) affinity , on various aspects of the hypoxic response . - pubmed
Characterization of the defect in the Na (+)- phosphate transporter in vitamin D - resistant hypophosphatemic mice . - pubmed
The cause of the hypophosphatemia is thought to be secondary to a defect in the renal and/or intestinal Na (+)- phosphate transporter . - pubmed
The effects of interferon - alpha on the proliferation of CML progenitor cells in vitro are not related to the precise position of the M - BCR breakpoint . - pubmed
We investigated the effects of brief ( 2 h ) and continuous exposure to recombinant interferon - alpha ( 2a ) ( rIFN - alpha ) on the proliferation of primitive ( blast colony - forming cells , Bl - CFC ) and committed myeloid progenitor cells ( BFU - E and GM - CFC ) derived from blood and bone marrow of patients with chronic myeloid leukaemia ( CML ) and normal subjects . - pubmed
No differences were detected in the proliferation of CML or normal Bl - CFC and GM - CFC exposed to rIFN - alpha . - pubmed
We conclude that ( 1 ) rIFN - alpha does not have a significant leukaemia - specific effect on the progenitor cells detected in these assays , and ( 2 ) the sensitivity of CML GM - CFC to rIFN - alpha is independent of the type of BCR / ABL message present in the cells . - pubmed
Removal of exposed , terminal sialic acid ( SA ) from carbohydrate chains N - glycosidically linked to asparagine residues of highly pure human C5 with bacterial sialidase increased C - mediated hemolysis of antibody - sensitized sheep E maximally 2.77 - fold . - pubmed
Differences in c - myc and pvt-1 amplification in SEWA sarcoma sublines selected for adherent or non - adherent growth . - pubmed
Enhanced peripheral and splanchnic insulin sensitivity in NIDDM men after single bout of exercise . - pubmed
We studied glucose metabolism in non - insulin - dependent diabetic ( NIDDM ) men with and without glycogen - depleting cycle exercise 12 h beforehand and have compared the results to our previous data in lean and obese subjects . - pubmed
The MCR of glucose during both insulin infusions was reduced in NIDDM compared with lean subjects but was very similar to that in obese nondiabetics . - pubmed
The presence of viral antigen in the cells was determined by quantitative indirect immunofluorescence assays using a working dilution of 1:20 of a serum from an AIDS patient as the immune serum . - pubmed
In contrast , highly purified native C5 induced no evidence of pulmonary inflammation , even at the highest injection doses studied . - pubmed
The RIA for MFGM - gp 70 showed that the amount of antigen shed was much higher in supernatants from normal mammary epithelial cells compared with their malignant counterparts grown in primary culture and with those from established cell lines of malignant mammary epithelial cells . - pubmed
In this study , the antithrombotic properties of intact high - affinity heparin ( Mr = 15,000 ) and of two heparin fragments ( h16 , a 16 - monosaccharide fragment , with Mr = 4,300 , and h12 , a 12 - monosaccharide fragment , with Mr = 3,200 ) and of their functional covalent stoichiometric complexes with human AT were compared in a venous thrombosis stasis model in rabbits . - pubmed
Staining for myofibrillar ATPase revealed that all well - differentiated ALD - derived muscle fibres were of the beta ' type , while PLD - derived fibres were of beta and beta R types . - pubmed
All 10 were young ( mean 12 years ) , had no serum alpha - fetoprotein , and no underlying cirrhosis ; all had a longer survival compared with patients without increased serum unsaturated vitamin B12 binding capacity in the study . - pubmed
Seven of the 10 patients had fibrolamellar hepatocellular carcinoma , a recently recognised histological variant , which was found in only one young patient without increased serum unsaturated vitamin B12 binding capacity and no alpha - fetoprotein among the remaining 97 . - pubmed
Increased serum unsaturated vitamin B12 binding capacity may be of considerable help in diagnosis , prognosis , and monitoring treatment of this well - defined group of patients with hepatocellular carcinoma but no alpha - fetoprotein . - pubmed
Under these conditions , the average glucose infusion rate ( M ) is an index of glucose metabolic rate , the average insulin response ( I ) is an index of beta cell responsiveness to hyperglycemia , and the M / I ratio is an index of insulin sensitivity . - pubmed
Enterotoxigenic Escherichia coli and other gram - negative bacteria of infantile diarrhea : surface antigens , hemagglutinins , colonization factor antigen , and loss of enterotoxigenicity . - pubmed
Most populations of human leukemic acute myeloblastic leukemia ( AML ) cells express c - Kit on their surface and respond to Kit ligand ( KL ) in culture . - pubmed
The model will be useful for studying the progression of leukemia in vivo and testing whether interruption of the interaction of Kit and KL can affect the growth of leukemic cells . - pubmed
CTLA-4 gene polymorphism associated with Graves ' disease in a Caucasian population . - pubmed
The CTLA-4 gene or a closely associated gene ( including CD28 ) confers susceptibility to GD . - pubmed
Neurasthenic fatigue , chemical sensitivity and GABAa receptor toxins . - pubmed
Following observation of fatigue syndromes in people who have been occupationally exposed to pesticides and insecticides which exert their toxicity through the GABAa receptor , we have formulated the hypothesis that fatigue syndromes in general may be secondary to altered sensitivity of the GABAa receptor . - pubmed
avium to Tat protein in the presence of IL-6 enhanced the growth of AIDS - associated strains . - pubmed
Association between lipoprotein ( a ) and progression of coronary artery disease in middle - aged men . - pubmed
The association between lipoprotein ( a ) ( Lp [ a ] ) and progression of coronary artery disease ( CAD ) compared with other serum lipids was evaluated in 104 patients with angiographically proven coronary atherosclerosis . - pubmed
Patients with or without previous myocardial infarction ( 70 vs 34 ) did not differ in Lp ( a ) levels ( median 9.15 vs 14.25 mg / dl ) . - pubmed
Patients with Lp ( a ) & gt ; 25 mg / dl were younger than patients with Lp ( a ) & lt ; or = 25 mg / dl ( 52 vs 55 years ; p & lt ; 0.03 ) , indicating a connection between Lp ( a ) and the development of premature CAD.(ABSTRACT TRUNCATED AT 250 WORDS ) - pubmed
The p53 tumor suppressor limits cellular proliferation by inducing either G1 arrest or apoptosis , depending on the cellular context . - pubmed
Camptothecin and minor - groove binder hybrid molecules : synthesis , inhibition of topoisomerase I , and anticancer cytotoxicity in vitro . - pubmed
In contrast , in the case of the cell lines SKOV3 and HT29 there was a general correlation between the better topoisomerase inhibitors and their cell cytotoxicities . - pubmed
During the acute and subacute stage , the diagnosis of luminal thrombus can be difficult , because signal ambiguities exist between hemoglobin breakdown products and flow effects and adjacent fat tissues . - pubmed
Aromatase is a cytochrome P450 isozyme , whose inhibition is known to be therapeutically relevant in the treatment of the breast cancer . - pubmed
Neuropeptide Y inhibition of calcium channels in PC-12 pheochromocytoma cells . - pubmed
We previously demonstrated , using rat PC-12 pheochromocytoma cells differentiated to a sympathetic neuronal phenotype with nerve growth factor ( NGF ) , that neuropeptide Y ( NPY ) inhibits catecholamine synthesis as well as release . - pubmed
Acute myocardial infarction with large bilateral intracoronary thrombi in a young patient with the prothrombin 20210 G-->A mutation . - pubmed
A genetic variation in the 3'-UT region of the prothrombin gene , a G to A mutation at nucleotide 20210 , has been associated recently with increased risk of acute myocardial infarction . - pubmed
Changes in the expression of syndecan-1 in the colorectal adenoma - carcinoma sequence . - pubmed
Tumour development in the large bowel is associated with loss of normal epithelial adhesion and altered patterns of expression of cell adhesion molecules , possibly including syndecan-1 . - pubmed
To evaluate changes in syndecan-1 expression during the development of colorectal neoplasia , 59 adenomas and 20 carcinomas arising from adenomas were investigated by immunohistochemistry . - pubmed
Staining of syndecan-1 and E - cadherin was uniform in normal colorectal epithelial cells , and located at the basolateral surface . - pubmed
Similarly , there was a significant reduction of both molecules in carcinomas compared with associated adenomas ( syndecan-1 P = 0.00003 ; E - cadherin P = 0.002 ) . - pubmed
Our results support these findings and indicate that disruption of cell - matrix adhesion is critical in colorectal carcinogenesis , probably preceding changes in the purely homotypic cell - cell adhesion mediated by E - cadherin . - pubmed
MHC class Ia - deficient mice ( H2 Kb-/- Db-/- ) inoculated with the intracellular pathogen Listeria monocytogenes ( LM ) displayed a three- to fourfold expansion of splenic CD8 + T cells 6 days following infection . - pubmed
In vivo analysis showed that B6 and Kb-/- Db-/- mice clear LM from the spleen and liver rapidly with similar kinetics , whereas TAP.1-/- mice , which are deficient in class Ia and Ib molecules , clear LM slowly upon infection . - pubmed
Thus , class Ia - deficient animals have a CD8 + T cell repertoire capable of recognizing both class Ia and class Ib molecules and can generate protective immunity to LM . - pubmed
Levels of chemotactic cytokines , such as interleukin ( IL )- 8 , and monocyte chemotactic protein ( MCP )- 1 and levels of pro - inflammatory cytokines , such as tumor necrosis factor ( TNF )- alpha , interleukin ( IL )- 1beta and IL-6 , elevated in pleural effusion , and peak IL-1beta and IL-6 levels tended to be higher in clinical responders than non - responders . - pubmed
Modulation of immune function by dietary lectins in rheumatoid arthritis . - pubmed
By eliminating dietary elements , particularly lectins , which adversely influence both enterocyte and lymphocyte structure and function , it is proposed that the peripheral antigenic stimulus ( both pathogenic and dietary ) will be reduced and thereby result in a diminution of disease symptoms in certain patients with RA . - pubmed
[ Polymorphism of the vitamin D receptor and bone disease after renal transplantation ] . - pubmed
Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats . - pubmed
Human immunodeficiency virus type 1 ( HIV-1 ) isolates from 50 plasma specimens were analyzed for phenotypic susceptibility to licensed reverse transcriptase inhibitors and protease inhibitors by the Antivirogram and PhenoSense HIV assays . - pubmed
Cardiac overexpression of A1 - adenosine receptor protects intact mice against myocardial infarction . - pubmed
Previous studies have shown that high - level ( 300 - fold normal ) cardiac overexpression of A1 - adenosine receptors ( A1 - ARs ) in transgenic ( TG ) mice protects isolated hearts against ischemia - reperfusion injury . - pubmed
For these studies , we therefore selected a line of TG mice that overexpresses the A1 - AR at more moderate levels ( 30 - fold normal ) , which affords cardioprotection in the isolated heart while minimizing bradycardia and arrhythmia during ischemia in intact mice . - pubmed
Wild - type ( WT ; n = 10 ) and moderate - level A1 - AR TG ( n = 10 ) mice underwent 45 min of left anterior descending coronary artery occlusion , followed by 24 - h reperfusion . - pubmed
Cardiac overexpression of A1 - ARs reduces infarct size by 40 % and preserves cardiac function in intact mice after MI . - pubmed
Integrated effects of multiple modulators on human liver glycogen phosphorylase a. Hepatic glucose production is increased in people with type 2 diabetes . - pubmed
Immunocytochemical Localization of Glucose Transporter-2 ( GLUT-2 ) in Pancreatic Islets and Islet Cell Tumors . - pubmed
Using immunocytochemical staining , normal pancreases and 27 cases of islet cell tumors , including insulinomas , gastrinomas , glucagonomas , pancreatic polypeptide - omas ( PPomas ) , and a nonfunctioning islet cells tumor , were systematically stained for four different pancreatic hormones , gastrin , and GLUT-2 . - pubmed
Among islet cell tumors , insulinomas stained less strongly for GLUT-2 than normal beta - cells from the adjacent normal pancreas . - pubmed
Even nonfunctioning islet cell tumors were weakly stained for GLUT-2 . - pubmed
The positive staining for GLUT-2 observed for islets cells and all islet tumors is consistent with the notion that all pancreatic islet cells and islet cell tumors utilize glucose as a major fuel , requiring transporter - facilitated diffusion of glucose into the cells of normal organ and their tumors . - pubmed
alpha-2 - macroglobulin ( alpha-2 - M ) , a plasma proteinase inhibitor , plays an important role in the pathogenesis of lung inflammation . - pubmed
The purpose of this study was to develop a sensitive ELISA assay for rabbit alpha-2 - M to allow us to define the role of this protein in a rabbit model of lung inflammation / injury . - pubmed
With these antibodies , we developed two ELISA assays which were used to determine the concentration of alpha-2 - M in the lung fluids from rabbits with lung injury . - pubmed
[ Effects of nao - yi - an granule on the intercellular expression of IL-6 in the experimental intracerebral hemorrhagic brain of rats ] . - pubmed
OBJECTIVE : To define the cellular localization of IL-6 and the effects of the traditional Chinese medicine complex nao - yi - an granule ( NYA ) on the intercellular expression of IL-6 in the experimental intracerebral hemorrhagic ( ICH ) brain of rats , so as to investigate the efficacy mechanisms of NYA on ICH . - pubmed
METHODS : ICH rat models were established by stereotaxically injecting 0.4 U type VII collagenase into the right globus pallidus ( GP ) . - pubmed
RESULTS : Microglial activation was detected from 6 h to 4 d after ICH in the hematoma region , and reactive astrocytes were found from 6 h to 7 d after ICH around the hematoma region ; there was an up - regulation of IL-6 in the hematoma at 6 h after ICH ; it reached its peak at 12 h , and disappeared on 7 d. CONCLUSION : The major sources of IL-6 - positive protein were neurons and the activated microglia in the brain of ICH rats . - pubmed
Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia . - pubmed
The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. - pubmed
Effect of epoxide hydrolase polymorphisms on chromosome aberrations and risk for lung cancer . - pubmed
Therefore , we have investigated the association of two polymorphisms at exons 3 and 4 of the mEH gene with the development of lung cancer in 110 patients and 119 matched controls . - pubmed
In addition , we have investigated the relationship between the different mEH alleles and the frequency of chromosome aberrations ( CA ) , as an approach to understand the role of genetic susceptibility on cancer risk . - pubmed
In conclusion , the CA data provides evidence to support that susceptibility mEH alleles are significantly involved with the development of lung cancer from cigarette smoking . - pubmed
[ Phosphatase index in the differential diagnosis of ascites ] . - pubmed
RESULTS : T - cell positive patients had a shorter duration of diabetes ( 6.7+/-2.5 years ) than T - cell negative patients ( 9.2+/-5.0 years , p=0.011 ) and lower albumin excretion rate , but they had a similar glomerular filtration rate and blood pressure . - pubmed
Response of the megaloblastic anaemias of pregnancy to animal protein factor ; preliminary report . - pubmed
We show that macrophages from X - linked immunodeficient ( XID ) mice lacking functional Btk can not generate efficient bursts of reactive oxygen intermediates ( ROIs ) . - pubmed
Pharmacogenetics of dopamine receptors and response to antipsychotic drugs in schizophrenia -- an update . - pubmed
Nociceptin , a 17 amino acid opioid - like peptide that has an inhibitory effect on synaptic transmission in the nervous system , is involved in learning , memory , attention , and emotion and is also implicated in the perception of pain and visual , auditory , and olfactory functions . - pubmed
Effect of hepatic lipase -514C->T polymorphism and its interactions with apolipoprotein C3 -482C->T and apolipoprotein E exon 4 polymorphisms on the risk of nephropathy in chinese type 2 diabetic patients . - pubmed
Patients with diabetic nephropathy have increased plasma triglycerides and reduced activity of hepatic lipase ( HL ) , which hydrolyzes triglycerides . - pubmed
We hypothesized that the HL -514C-->T polymorphism , which reduces HL expression , and its interactions with polymorphisms in apolipoprotein ( apo ) E and apoC3 increase the risk of diabetic nephropathy . - pubmed
RESEARCH DESIGN AND METHODS : In a case - control study involving 374 Chinese type 2 diabetic patients with and 392 without diabetic nephropathy , we genotyped the HL -514C-->T , apoE exon 4 , and apoC3 -482C-->T polymorphisms . - pubmed
Adjustment by multiple logistic regression for hypertension , triglycerides , sex , non - HDL cholesterol , BMI , smoking , and alcohol intake did not diminish the association ( OR = 1.8 , P = 0.003 ) . - pubmed
The association between HL T+ genotypes and diabetic nephropathy appeared stronger in diabetic patients with apoC3 -482 non - TT genotypes ( OR = 1.9 , P = 0.003 ) or apoE epsilon2 or epsilon4 alleles ( OR = 2.2 , P = 0.005 ) . - pubmed
Subjects with HL TT exhibited trends toward increased triglyceride and non - HDL cholesterol levels compared with CC carriers . - pubmed
, hyperglycemia ) , lipid abnormalities may damage the kidneys and endothelium , where reduced binding sites for lipases may precipitate a vicious cycle of dyslipidemia , proteinuria , and nephropathy . - pubmed
Pravastatin appears to be the best HMG - CoA reductase inhibitor for organ transplant recipients because of its lesser potential to interact with cyclosporin and hence cause myositis , which may thus allow higher doses to be used . - pubmed
DE-310 , a macromolecular prodrug of the topoisomerase - I - inhibitor exatecan ( DX-8951 ) , in patients with operable solid tumors . - pubmed
Cystamine , an inhibitor of transglutaminases , slows progression of Huntington ' s disease in the murine model by approximately 20 % . - pubmed
Considering that MA could be acting as an immunomodulator preventing the development of herpetic stromal keratitis in mice , we also examined an eventual effect of CDM on NF - kappaB signaling pathway . - pubmed
G - CSF could worsen anaemia in breast cancer . - pubmed
Bone mineral density , bone turnover , and osteoprotegerin in depressed women with and without borderline personality disorder . - pubmed
Therefore , we examined bone density , markers of bone turnover , and proinflammatory cytokines in depressed patients with and without BPD . - pubmed
Osteocalcin , a marker of osteoblastic activity , and crosslaps , a marker of bone loss , were significantly different between the study groups . - pubmed
Expression of heat shock protein 47 in the fibrous tissue adjacent to mouse tumour subjected to photodynamic therapy . - pubmed
The reaction of normal fibrous tissue adjacent to tumours subjected to photodynamic therapy ( PDT ) was investigated by assessment of the immunohistochemical expression of heat shock protein 47 ( HSP47 ) and proliferating cell nuclear antigen ( PCNA ) , as well as by immunoblot analysis of procollagen type I. - pubmed
The expression of procollagen type I in the fibrous tissue adjacent to the tumours was examined by immunoblot analysis at intervals of 24 and 48h after PDT . - pubmed
The expression of HSP47 was first detected 6h post - PDT in the tumour - bearing mice , but no such expression was observed in the normal mice . - pubmed
It was also revealed that , after PDT , the fibroblast PCNA labeling indices at 24 , 48 , and 72h were significantly higher in both the tumour - bearing and the normal mice than in the control animals that did not receive PDT . - pubmed
Furthermore , procollagen type I was detected in the fibrous tissue adjacent to the tumours at 24 and 48h after PDT , but was not detected in the fibrous tissue adjacent to tumours of mice that did not receive PDT . - pubmed
Therefore , the present results suggest that PDT enhances the synthesis of collagen type I in the fibrous tissue adjacent to NR - S1 squamous cell carcinoma in mice , which contributes to the resultant encapsulation of such tumours . - pubmed
We assessed the complement C3 and C4 concentration ratio ( C3 / C4 ratio ) in serum as a potential measurement to predict cardiovascular attacks . - pubmed
In conclusion , increased serum C3 / C4 ratio is a readily available and novel marker for recurrent cardiovascular events in acute coronary syndrome . - pubmed
Cerebral cavernomas in a family with multiple cutaneous and uterine leiomyomas associated with a new mutation in the fumarate hydratase gene . - pubmed
TACE : a new target in epidermal growth factor receptor dependent tumors . - pubmed
This review focuses on a subset of these proteins , which are cleaved by tumor necrosis factor alpha - converting enzyme ( TACE)/ADAM17 , and on their role in cancer . - pubmed
A novel " pearl box " cataract associated with a mutation in the connexin 46 ( GJA3 ) gene . - pubmed
PURPOSE : To undertake mutation screening in the connexin 46 ( GJA3 ) gene in seven congenital cataract families of Indian origin . - pubmed
These findings thus expand the mutation spectrum of the GJA3 in association with congenital cataract . - pubmed
[ Clinical significance of FLT3 internal tandem duplication in acute myeloid leukemia with chromosome abnormality ] . - pubmed
This study was to explore the clinical significance of FLT3 internal tandem duplication ( FLT3 / ITD ) in acute myeloid leukemia ( AML ) with chromosome abnormality . - pubmed
Using genomic PCR and sequencing , FLT3 / ITD mutation in AML patients with or without chromosome abnormity were examined . - pubmed
In 79 samples without chromosome abnormality , FLT3 gene expression was detected in 56 samples , the positive rate was 70.89 % . - pubmed
Clinical data showed that the difference was no statistically significant ( p & gt ; 0.05 ) in leukocyte counting and Hb assay in peripheral blood as well as leukocyte ratio in bone marrow of these two groups with or without chromosome abnormality . - pubmed
Most FLT3 / ITD mutation patients with or without chromosome abnormality died in short time , the difference of death rate was not statistically significant between these two groups ( p & gt ; 0.05 ) while the life span of FLT3 / ITD mutation patients with chromosome abnormality was even shorter than the other . - pubmed
It is concluded that prognosis is relatively poor in FLT3 / ITD mutation patients with chromosome abnormality . - pubmed
FLT3 / ITD mutation may be an important marker for poor prognosis of AML . - pubmed
CAP ( 10mg / kg body weight ) pretreatment decreased lung mitochondrial LPO and augmented the activities of enzymic , non - enzymic antioxidants , citric acid cycle enzymes and respiratory chain enzymes to near normalcy revealing its chemoprotective function during B ( a ) P induced lung cancer . - pubmed
The role of cyclase activating ( CAP ) and cyclase inhibiting ( CIP ) parathormone fractions in the assessment of bone metabolism disturbances in women with hyperprolactinemia of various origin . - pubmed
The reason is thought to be connected with hypogonadism due to PRL excess and the role of other hormones like PTH and PTH - rP. - pubmed
There is no data on the influence of PTH fractions ( CAP and CIP ) on bone turnover and density in hyperprolactinemia . - pubmed
The aim of the study was to assess the influence of PTH and its fractions on bone metabolism in hyperprolactinemia of various origin . - pubmed
RESULTS : In patients with functional hyperprolactinemia i - PTH and CAP levels were lower than in controls . - pubmed
CAP / CIP ratio was higher in patients with prolactinoma than in patients with functional hyperprolactinemia and controls . - pubmed
CONCLUSIONS : There is no direct benefit from the assessment of parathormone fractions and CAP / CIP ratio in the prognosis of bone metabolism changes in hyperprolactinemia of various origin . - pubmed
Effects of low - dose parathyroid hormone on bone mass , turnover , and ectopic osteoinduction in a rat model for chronic alcohol abuse . - pubmed
Parathyroid hormone ( PTH ) is used clinically in osteoporotic patients to increase bone mass by enhancing bone formation . - pubmed
Based on the animal model , our findings suggest that alcohol consumption could impair the beneficial effects of PTH therapy in osteoporosis . - pubmed
His initial laboratory examination showed leukocytosis , eosinophilia , and elevated C - reactive protein . - pubmed
Complement fixation for coccidioidomycosis performed on a serum sample was positive at a titer of 1:2 but a latex agglutinin test was negative . - pubmed
Molecular network analysis of T - cell transcriptome suggests aberrant regulation of gene expression by NF - kappaB as a biomarker for relapse of multiple sclerosis . - pubmed
The molecular network of 43 DEG investigated by KeyMolnet , a bioinformatics tool for analyzing molecular interaction on the curated knowledge database , showed the most significant relationship with aberrant regulation of gene expression by the nuclear factor - kappa B ( NF - kappaB ) in T cells during MS relapse . - pubmed
These results support the logical hypothesis that NF - kappaB plays a central role in triggering molecular events in T cells responsible for induction of acute relapse of MS , and suggest that aberrant gene regulation by NF - kappaB on T - cell transcriptome might serve as a molecular biomarker for monitoring the clinical disease activity of MS . - pubmed
Transforming growth factor - beta signaling and cancer : the 28th Sapporo Cancer Seminar , 25 - 27 June 2008 . - pubmed
The 28th Sapporo Cancer Seminar was held on 26 - 27 June 2008 at the Hokkaido University Conference Hall , focusing on transforming growth factor ( TGF )- beta signaling and cancer . - pubmed
More than 150 scientists participated in the seminar , and it provided a great deal of information on the role of TGF - beta signaling in carcinogenesis and tumor metastasis . - pubmed
The possible use of TGF - beta antagonists for treatment of cancers was also discussed at the seminar . - pubmed
The efficacies of other novel targeted inhibitors such as deacetylase inhibitors and heat shock protein 90 inhibitors in the treatment of gliomas are also discussed , as well as new combination therapies . - pubmed
[ The polymorphism of cytochrome P ( 450 ) 2C19 gene in patients with invasive fungal infections . ] - pubmed
OBJECTIVE : To investigate the polymorphism profile of cytochrome P ( 450 ) 2C19 ( CYP2C19 ) in Chinese patients with invasive fungal infections . - pubmed
METHODS : Two major single nucleotide polymorphism loci of the CYP2C19 gene ( CYP2C19 * 2 and CYP2C19 * 3 ) were genotyped with PCR and restriction fragment length polymorphism ( PCR - RFLP ) in 134 patients with invasive fungal infections and 134 healthy volunteers . - pubmed
RESULTS : In patients with invasive fungal infections , CYP2C19 * 1 , CYP2C19 * 2 and CYP2C19 * 3 alleles showed frequencies of 58.2 % , 36.6 % and 5.2 % . - pubmed
BACKGROUND : Spinal cord neurons of ALS patients demonstrate reduced cytochrome oxidase histochemical activity , and ALS spinal cord tissues have increased mitochondrial DNA ( mtDNA ) point mutations and depleted mtDNA levels . - pubmed
Plots of ratios of ND4 / ND2 and CO3 / ND2 showed that many but not all ALS neurons from individuals contained low ratios of these mtDNA genes , implying greater abundances of mtDNA deletions in the major arc . - pubmed
If these anterior spinal neuron mtDNA gene deficiencies contribute to bioenergetic impairments , reduced synaptic function and increased risk of degeneration , then introduction into mitochondria and expression of intact mtDNA , now available through use of recently developed recombinant human TFAM , may reverse the course of ALS . - pubmed
Oxidative stress and amyloid - beta pathology in normal individuals with a maternal history of Alzheimer ' s . - pubmed
All subjects completed clinical neuropsychological examinations and a lumbar puncture to measure CSF levels of amyloid - beta ( Abeta ( 40 ) , Abeta ( 42 ) , Abeta(42/40 ) ) , total and hyperphosphorylated tau ( T - Tau and P - Tau(231 ) ; markers of axonal degeneration and neurofibrillary tangles , respectively ) , and F2 - isoprostanes ( IsoP ) ( a marker of oxidative stress ) . - pubmed
The MH subjects showed higher IsoP and reduced Abeta ( 42 / 40 ) CSF levels compared with NH and with PH ( p values < = .05 ) , whereas no differences were found between NH and PH . - pubmed
CONCLUSIONS : Adult children of LOAD - affected mothers express a pathobiological phenotype characterized by Abeta - associated oxidative stress consistent with AD , which might reflect increased risk for developing the disease . - pubmed
PSA and beyond : the past , present , and future of investigative biomarkers for prostate cancer . - pubmed
The discovery of prostate - specific antigen ( PSA ) as a biomarker represented a major discovery in the early diagnosis and monitoring of prostate cancer . - pubmed
The purpose of this study is to review available data on prostate cancer biomarkers for prostate cancer screening and prognostication , including prostatic acid phosphatase , PSA , PSA derivatives ( PSA density , free PSA , pro PSA , and PSA kinetics ) , PCA3 , GSTP1 , AMACR , and other newly emerging molecular and genetic markers . - pubmed
PEP-1 - SOD1 protects brain from ischemic insult following asphyxial cardiac arrest in rats . - pubmed
Copper , zinc - superoxide dismutase ( SOD1 ) is one of the major defensive mechanisms by which cells counteract the deleterious effects of ROS after ischemia . - pubmed
Moreover , we determined whether or not PEP-1 - SOD1 can protect brain from ischemic injury in an experimental asphyxial cardiac arrest rat model through histopathologic analysis , evaluating the levels of malondialdehyde ( MDA ) , S100beta and neuron specific enolase ( NSE ) . - pubmed
The transduced PEP-1 - SOD1 significantly attenuated cerebral ischemia - reperfusion damage , inhibited ischemia - induced lipid peroxidation , and protected neurons in hippocampus from the damage induced by transient global ischemic insults . - pubmed
CONCLUSIONS : PEP-1 - SOD1 fusion protein can be transduced into the neurons in vivo and protect the neurons from the transient global ischemia - induced damage , suggesting PEP-1 - SOD1 may be used for the treatment of oxidative stress - associated disorders such as transient global cerebral ischemia . - pubmed
Here , we review the function of OAT3 and OCT3 at the BBB and BCSFB in the context of their roles in the progression of renal failure . - pubmed
Dermatological adverse effects during genotype-1 hepatitis C treatment with the protease inhibitors telaprevir and boceprevir . - pubmed
Hemoglobin level and survival in hemodialysis patients with polycystic kidney disease and the role of administered erythropoietin . - pubmed
Interventional trials indicate adverse outcomes when hemoglobin & gt;13 g / dL is targeted in patients with chronic kidney disease ( CKD ) who receive erythropoiesis - stimulating agents ( ESAs ) . - pubmed
It is not clear whether high - achieved hemoglobin with minimal to no ESA administration as observed in some patients with polycystic kidney disease ( PKD ) is also associated with poor outcomes . - pubmed
Survival models were examined to assess the association between hemoglobin increments and mortality in a 6 - year cohort of 2,402 PKD and 110,875 non - PKD hemodialysis patients across infrequent versus frequent ESA therapy defined as ESA & lt ; 25 % of cohort time versus otherwise , respectively . - pubmed
Hence , in patients with PKD who require infrequent ESA , incrementally higher achieved hemoglobin including & gt ; 13.0 g / dL exhibits better survival ; this incremental survival gain of higher hemoglobin is not observed in patients with PKD receiving frequent ESA administration , in whom hemoglobin concentration & gt ; 13 exhibits increased mortality . - pubmed
Two cases with severe lethal course of Costello syndrome associated with HRAS p. G12C and p. G12D. - pubmed
Heterozygous de novo germline mutations in the proto - oncogene HRAS cause CS . - pubmed
Other less common lesions in HRAS can induce a milder phenotype on the one hand and a more severe phenotype on the other broadening the spectrum of clinical manifestations in CS - affected individuals . - pubmed
The content of glycated hemoglobin , a biomarker of diabetes in patients with type 2 diabetes correlates with risk factors for cardiovascular disease : hypertension , BMI and ratio of total cholesterol to HDL cholesterol . - pubmed
Therefore , increase in glycosylated hemoglobin should be considered a predictor of cardiovascular disease in patients with type 2 diabetes . - pubmed
Relationship between the chemokine receptor CCR5 and microglia in neurological disorders : consequences of targeting CCR5 on neuroinflammation , neuronal death and regeneration in a model of epilepsy . - pubmed
Chemokines may play a role in leukocyte migration across the blood - brain barrier ( BBB ) during neuroinflammation and other neuropathological processes , such as epilepsy . - pubmed
The current review examines the relationship between CCR5 and the microglia in different neurological disorders and models of CNS injury . - pubmed
CCR5 expression is upregulated in different neurological diseases , where it is often immunolocalized in microglial cells . - pubmed
Consequently , targeting CCR5 by using CCR5 antagonists may attenuate critical aspects of neuroinflammation in different models of neurological disorders . - pubmed
To illustrate the interaction between CCR5 and microglia in the CNS , we used a model of excitotoxicity , and demonstrate the intimate involvement of CCR5 in neuron injury and inflammation attendant to kainic acid ( KA)-induced neurotoxicity . - pubmed
CCR5 participates in neuronal injury caused by the excitotoxin , KA , brings inflammatory cells to the sites of KA - induced CNS injury , defines the extent of tissue loss after KA exposure and limits reparative responses . - pubmed
Thus , therapeutic targeting of CCR5 may allow control of potentially injurious neuroinflammatory responses , including decrease in microglial cells activation and proliferation , and facilitate neurogenic repair in seizure - induced and , potentially , other forms of CNS injury . - pubmed
Here we report the case of a patient with diffuse cutaneous SSc who was administered anti - interleukin-6 receptor antibody tocilizumab ( TCZ ) . - pubmed
Pentoxifylline does not alter the concentration of hepcidin in chronic kidney disease patients undergoing hemodialysis . - pubmed
INTRODUCTION : Anemia is a frequent condition in patients with chronic kidney disease due to a reduction in the production of erythropoietin . - pubmed
Patients with inflammation respond less well to treatment with erythropoietin , possibly because the increased production of hepcidin reduces the availability of iron for hematopoiesis . - pubmed
OBJECTIVE : The aim of this study was to analyze the effect of pentoxifylline on serum hepcidin in chronic hemodialysis patients with inflammation . - pubmed
Moreover , EGCG alleviates CD4(+ ) CD45RB(hi ) CD25(- ) T cell transfer induced colitis with less accumulation of CD4(+ ) T cells in the colon . - pubmed
In conclusion , the present study reports an alternative activation of STAT1 via Src by EGCG in IFN - gamma - activated CD4 (+ ) T cells , which promotes the apoptosis of IFN - gamma - activated CD4(+ ) T cells and contributes to the improvement of T cell - mediated colitis . - pubmed
Our findings suggest a novel role of EGCG in regulating IFN - gamma signaling and controlling inflammation . - pubmed
WAT showed an increase in inflammation and ER stress and brown adipocytes suffered a brown - to - white transformation and decreased UCP-1 expression . - pubmed
Prostate - specific antigen - based prostate cancer screening : Past and future . - pubmed
Prostate - specific antigen - based prostate cancer screening remains a controversial topic . - pubmed
Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety . - pubmed
The intrinsic excitability of contralateral PL excitatory neurons is decreased in chronic pain rats ; knocking down cyclin - dependent kinase 5 reverses this deactivation and alleviates behavioural impairments . - pubmed
The Effects of a GLP-1 Analog on Glucose Homeostasis in Type 2 Diabetes Mellitus Quantified by an Integrated Glucose Insulin Model . - pubmed
In recent years , several glucagon - like peptide-1 ( GLP-1)-based therapies for the treatment of type 2 diabetes mellitus ( T2DM ) have been developed . - pubmed
The aim of this work was to extend the semimechanistic integrated glucose - insulin model to include the effects of a GLP-1 analog on glucose homeostasis in T2DM patients . - pubmed
Data from two trials comparing the effect of steady - state liraglutide vs. placebo on the responses of postprandial glucose and insulin in T2DM patients were used for model development . - pubmed
Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea . - pubmed
AIM : To investigate associations between the tumor necrosis factor alpha ( TNF - alpha ) -1031 T>C , -863 C>A , -857 C>T , -308 G>A , and -238 G>A polymorphisms and HCC in Korea . - pubmed
The association between TNF - alpha polymorphisms and HCC was analyzed in 157 HCC patients and 201 controls using a polymerase chain reaction - restriction fragment length polymorphism assay . - pubmed
The TNF - alpha genotype frequencies , genotype combinations and haplotypes were analyzed to disclose the association with HCC . - pubmed
RESULTS : None of the TNF - alpha polymorphisms was significantly associated with HCC . - pubmed
Among them , TNF - alpha -1031/-857/-238 TT / CC / GA ( AOR = 18.849 , 95%CI : 2.203 - 161.246 , P = 0.007 ) , TNF - alpha -1031/-308/-238 TT / GG / GA ( AOR = 26.956 , 95%CI : 3.071 - 236.584 , P = 0.003 ) , and TNF - alpha -1031/-238 TT / GA ( AOR = 21.576 , 95%CI : 2.581 - 180.394 , P = 0.005 ) showed marked association with HCC . - pubmed
There were five haplotypes of TNF - alpha polymorphisms which were significantly associated with HCC . - pubmed
Moreover , HCC Okuda stage III cases with the TNF - alpha -1031 CC genotype had better survival than those with the TT genotype ( AOR = 5.795 , 95%CI : 1.145 - 29.323 ) . - pubmed
CONCLUSION : Although no single TNF - alpha polymorphism is associated with HCC in this study , some TNF - alpha genotype combinations and haplotypes are associated with HCC . - pubmed
In addition , HCC Okuda stage III cases with the TNF - alpha -1031 TT genotype may have a better prognosis than those with the CC genotype . - pubmed
AIM : Previous studies showed that circulating fibroblast growth factor-23 ( FGF23 ) is a new biomarker linked to cardiovascular and kidney diseases . - pubmed
The study demonstrates for the first time sex - and structure - specific changes in the response of the thioredoxin system to MeHg neurotoxicity and suggests that these differences in antioxidant responses might impart differential susceptibility to developmental MeHg exposure . - pubmed
The free light chain ( FLC ) assay is also useful in the diagnosis and therapeutic monitoring of MM . - pubmed
Association of polymorphisms in PATE1 gene with idiopathic asthenozoospermia in Sichuan , China . - pubmed
However , the single nucleotide polymorphisms ( SNPs ) of the PATE1 gene which contribute to AZS were still unknown . - pubmed
For this reason , the possible association between the single nucleotide polymorphisms of the PATE1 gene and idiopathic asthenozoospermia was investigated in this research . - pubmed
The sequence analyses of the PATE1 gene were conducted in 108 idiopathic asthenozoospermia and 106 fertile men with normospermic parameters in Sichuan , China . - pubmed
CONCLUSIONS : These results suggested that PATE1 variant ( A1423 G ) was probably one of the high risk genetic factors for idiopathic asthenozoospermia among males in Sichuan , China . - pubmed
Vitreous Fibronectin and Fibrinogen Expression Increased in Eyes With Proliferative Diabetic Retinopathy After Intravitreal Anti - VEGF Therapy . - pubmed
Purpose : To evaluate vitreous humor ( VH ) protein expression profiles in patients with proliferative diabetic retinopathy ( PDR ) , with and without intravitreal injection ( IVI ) of anti - vascular endothelial growth factor ( anti - VEGF ) before vitrectomy . - pubmed
Conclusions : VH fibronectin and fibrinogen concentrations were highest in the IVI patients , which may promote fibrin - fibronectin complexation and fibrosis in eyes with PDR . - pubmed
Repeated vaccination with tetanus toxoid of plasma donors with pre - existing specific IgE transiently elevates tetanus - specific IgE but does not induce allergic symptoms . - pubmed
The questionnaire was administered to 219 individuals at risk of RA on the basis of symptoms or autoantibody positivity : 74 % rheumatoid factor and/or anticitrullinated protein antibodies positive , 26 % seronegative . - pubmed
Prealbumin and lymphocyte - based prognostic score , a new tool for predicting long - term survival after curative resection of stage II / III gastric cancer . - pubmed
Although liver enzymes , bilirubin and albumin demonstrated a circadian pattern , it was not associated with fatigue . - pubmed
Long noncoding RNA MNX1 - AS1 contributes to lung cancer progression through the miR-527 / BRF2 pathway . - pubmed
LncRNA MNX1 - AS1 is proven to regulate colon adenocarcinoma , cervical cancer , glioblastoma , and ovarian cancer . - pubmed
Whether MNX1 - AS1 participates in lung cancer needs investigation . - pubmed
In our research , we found that MNX1 - AS1 was dramatically upregulated in lung cancer . - pubmed
MNX1 - AS1 upregulation indicated poor prognosis in lung cancer patients . - pubmed
Functionally , MNX1 - AS1 promoted lung cancer progression through regulating proliferation , migration , and invasion . - pubmed
Taken together , our study found a novel signaling pathway , namely MNX1 - AS1 / miR-527 / BRF2 axis , involved in lung cancer progression . - pubmed
The CD98 Heavy Chain Is a Marker and Regulator of Head and Neck Squamous Cell Carcinoma Radiosensitivity . - pubmed
High SLC3A2 mRNA expression levels are associated with poor prognosis in patients with head and neck squamous cell carcinoma ( HNSCC ) treated with radiochemotherapy . - pubmed
Little is known regarding the CD98hc protein - mediated molecular mechanisms of tumor radioresistance . - pubmed
EXPERIMENTAL DESIGN : CD98hc protein expression levels were correlated with corresponding tumor control dose 50 ( TCD50 ) in HNSCC xenograft models . - pubmed
Expression levels of CD98hc and LAT1 in HNSCC cells were modulated by siRNA or CRISPR / Cas9 gene editing . - pubmed
Expression levels of CD98hc and LAT1 proteins were examined by IHC analysis of tumor tissues from patients with locally advanced HNSCC treated with primary radiochemotherapy ( RCTx ) . - pubmed
High expression levels of CD98hc and LAT1 proteins were significantly correlated and associated with an increase in radioresistance in HNSCC in vitro and in vivo models . - pubmed
CONCLUSIONS : We found that CD98hc - associated signaling mechanisms play a central role in the regulation of HNSCC radioresistance and may be a promising target for tumor radiosensitization . - pubmed
The developmental / pathogenic contribution of the t(4;11)-resulting MLL - AF4 ( MA4 ) and AF4 - MLL ( A4 M ) fusions remains unclear ; MA4 is always expressed in patients with t(4;11)+ B - cell acute lymphoblastic leukemia , but the reciprocal fusion A4 M is expressed in only half of the patients . - pubmed
Di ( 2 - ethyl hexyl ) phthalate ( DEHP)-induced spleen toxicity in quail ( Coturnix japonica ) via disturbing Nrf2 - mediated defense response . - pubmed
Individual free fatty acids have unique associations with inflammatory biomarkers , insulin resistance and insulin secretion in healthy and gestational diabetic pregnant women . - pubmed
Objective : We investigated the relationships of maternal circulating individual free fatty acids ( FFA ) with insulin resistance , insulin secretion and inflammatory biomarkers during mid - pregnancy . - pubmed
We quantitatively determined 11 FFAs , seven cytokine / adipokine , homeostatic model assessment of insulin resistance ( HOMA - IR ) and C - peptide levels from the fasting blood samples that were collected at 16 weeks of gestation . - pubmed
Results : High HOMA - IR ( p<0.001 ) and C - peptide ( p<0.0001 ) levels were positively associated with a twofold to fourfold increased risk for developing gestational diabetes mellitus ( GDM ) . - pubmed
Here , we found that the muscarinic acetylcholine receptor , cholinergic receptor , muscarinic 4 ( CHRM4 ) , pathway regulates BFU - E self - renewal and that pharmacological inhibition of CHRM4 corrects anemias of myelodysplastic syndrome ( MDS ) , aging , and hemolysis . - pubmed
Moreover , muscarinic acetylcholine receptor antagonists corrected anemias in mouse models of MDS , aging , and hemolysis in vivo , extending the survival of mice with MDS relative to that of controls . - pubmed
On the basis of these data , we propose a model of hematopoietic progenitor self - renewal through a cholinergic - mediated " hematopoietic reflex " and identify muscarinic acetylcholine receptor antagonists as potential therapies for anemias associated with MDS , aging , and hemolysis . - pubmed
We previously reported the reduction of RNA binding protein HuD in pancreatic beta - cells of diabetes . - pubmed
Downregulation of HuD increases the number of cells with fragmented mitochondria and reduces the mitochondrial activity determined by mitochondrial membrane potential and ATP production in mouse insulinoma betaTC6 cells . - pubmed
Ectopic expression of Mfn2 in betaTC6 cells stably expressing short hairpin RNA against HuD ( shHuD ) restores HuD - mediated mitochondrial dysfunction . - pubmed
Taken together , our results suggest that HuD regulates mitochondrial dynamics by regulating Mfn2 level and its reduced expression leads to mitochondrial dysfunction in pancreatic beta - cells . - pubmed
Apold1(apolipoprotein L domain containing 1 ) is a gene expressed by endothelial cells ; whether Apold1 directly contributes to arterial thrombosis has not yet been investigated . - pubmed
Here , we assessed the effect of Apold1 deletion on arterial thrombus formation using an in vivo model of carotid thrombosis induced by photochemical injury . - pubmed
MATERIAL AND METHODS : Apold1 knockout ( Apold1-/- ) mice and wild type ( WT ) littermates underwent carotid thrombosis induced by photochemical injury and time to occlusion was recorded . - pubmed
CONCLUSIONS : Deficiency of Apold1 results in a prothrombotic phenotype , accompanied by increased vascular TF activity , decreased PI3K / Akt activation and increased platelet reactivity . - pubmed
These findings suggest Apold1 as an interesting new therapeutic target in the context of arterial thrombosis . - pubmed
The findings from this study indicate that HULC , RP11 - 314B1.2 , LINC00106 , and RP11 - 999E24.3 could be considered as potential therapeutic targets or prognostic biomarkers in gastric cancer , and provide a new perspective for cancer pathogenesis research . - pubmed
pneumoniae lipid - associated membrane proteins ( LAMPs ) induces lung lesions consistent with exacerbated disease following challenge , without reducing bacterial loads . - pubmed
We identified less / no lipid signals within the tumor and intense deoxy - hemoglobin ( Hb ) signals on the rim of the tumor as unique characteristics of malignant tumors in comparison to no tumor region . - pubmed
Downregulationof pregnancy - specific beta-1 - glycoprotein 9 ( PSG9 ) in the LOPE group was confirmed by ELISA . - pubmed
Expressions ofm6A RNA methylation regulatorsand their clinical predictive value in cervical squamous cell carcinoma and endometrial adenocarcinoma . - pubmed
As a result , 5 m6A RNA methylation regulators ( FTO , HNRNPA2B1 , RBM15 , IGF2BP1 , IGF2BP3 ) were identified to be significantly linked to CESC tumor status . - pubmed
Antiplasmin concentrations after surgery : failure of alpha 2 - antiplasmin to rise in patients with venous thrombosis . - pubmed
These designations included the terms " insulin - dependent , " " idiopathic , " " insulin - requiring , " and " ketosis - prone . " - pubmed
Much progress could be accomplished , even in the absence of international standardized definitions and classification systems , provided that authors keep in mind the need to describe the major characteristics of their cases and define the sense in which they use terms such as insulin - dependent , ketosis - prone , obese , etc . - pubmed
Effect of erythropoietin therapy on the red cell volume of uraemic and non - uraemic rats . - pubmed
Studies were performed to determine the effect of injecting repeated doses of erythropoietin ( Ep ) on the red cell volume of chronically uraemic rats and on that of non - uraemic sham operated ones . - pubmed
[ Change in the amylase activity and microflora in the bile in cholecystitis ] . - pubmed
[ Aminoacids in the keratin of skin , hair and nails in psoriasis cases ( author 's transl ) ] . - pubmed
Comparative study of effects of cyclosporins A and G on collagen arthritis in mice . - pubmed
The effects of the immunosuppressive agents cyclosporin G ( CsG ) and cyclosporin A ( CsA ) on collagen arthritis were compared in mice . - pubmed
When administered subcutaneously daily on days 0 - 13 after immunization with type II collagen , CsG and CsA were both capable of suppressing the development of collagen arthritis in mice as well as the immunological response to native type II collagen in a dose - dependent manner . - pubmed
The sensitivity of the Na +/ H + exchanger to the oxidant , hydrogen peroxide ( H2O2 ) and the protection by the antioxidant GSH suggests a possible role for the Na+/H+ exchange mechanism in the formation of cataracts . - pubmed
The treatment of mesangial IgA nephropathy with cyclophosphamide , dipyridamole and warfarin . - pubmed
Cholesterol crystals and IgE - containing immune complexes in rheumatoid pericarditis . - pubmed
The schistosomal specificity of kidney lesions was assessed by detecting the schistosomal specific antigens ( CAA and CCA ) and antibodies deposited in the renal glomeruli of these patients . - pubmed
Viruses and cytokines : evidence for multiple roles in pancreatic beta cell destruction in type 1 insulin - dependent diabetes mellitus . - pubmed
To elucidate the possible role of viruses and cytokines in the pathogenesis of IDDM , we have examined the effect of reovirus infection on beta cell major histocompatibility complex ( MHC ) expression and the effect of interferon - gamma ( IFN - gamma ) and tumour necrosis factor - alpha ( TNF - alpha ) on beta cell function in vitro . - pubmed
Infection of RIN - m5F ( rat insulinoma ) cells with reovirus-1 or reovirus-3 was associated with a tenfold increase in class 1 MHC protein and mRNA expression . - pubmed
Reovirus infection did not induced the expression of class 11 MHC by RIN - m5F cells . - pubmed
We studied the regulation of glycogen metabolism and amino acid uptake in human cultured HEP - G2 hepatoma cells , which have distinct receptors for both insulin and IGF - I. - pubmed
[ Immunohistochemical study of carcinoembryonic antigen of the tissue and cell levels in adenocarcinoma of the uterus ] . - pubmed
UNLABELLED : Immunohistochemical staining was performed for carcinoembryonic antigen ( CEA ) in tissues taken from 41 cases of cervical and 67 cases of endometrial adenocarcinomas . - pubmed
THE RESULTS : 1 ) The investigation at the tissue level indicated that CEA staining was positive in 80 % of cases of cervical adenocarcinoma . - pubmed
3 ) Our observation revealed that CEA was more prominent in the poorly differentiated type than in the well differentiated one , in both cervical and endometrial adenocarcinoma . - pubmed
Next potential long term effects of insulin on the exocrine pancreas in vivo like regulation of the synthesis of certain digestive enzymes are described , followed by a discussion of long term insulin effects in vitro employing AR42J cells , a rat pancreatic carcinoma acinar in origin . - pubmed
[ Blood lipid and beta - lipoprotein shifts in acute digestive disorders in young children ] . - pubmed
Hepatocellular carcinoma in primary biliary cirrhosis : detection by alpha - fetoprotein estimation . - pubmed
Serial estimations of serum alpha - fetoprotein in 130 white patients from the United Kingdom with primary biliary cirrhosis who were followed for periods of 1 - 52 mo revealed 5 cases of hepatocellular carcinoma ; all were subsequently confirmed histologically . - pubmed
At the time alpha - fetoprotein was first noted to be elevated , none had signs or symptoms of tumor development . - pubmed
A rise in ambient temperature augments insulin absorption in diabetic patients . - pubmed
The absorption rate of 125I - Actrapid insulin ( 6 U ) from a subcutaneous injection site was examined in six insulin - dependent diabetic patients at ambient temperatures of 20 degrees C and 35 degrees C. During a 4 - hr observation period , the insulin disappearance rate at 35 degrees C was 50%-60 % greater than at 20 degrees C ( p less than 0.01 ) . - pubmed
Despite the small dose of insulin used , plasma glucose levels tended to be 1 to 2 mmole / liter lower at 35 degrees C than at 20 degrees C. These findings indicate that a rise in ambient temperature augments insulin absorption , in insulin - treated diabetic patients . - pubmed
Twenty - seven pregnant diabetic patients ( White 's class B through R ) received insulin dosages twice daily as a combination of NPH and regular insulin . - pubmed
Histochemical methods demonstrated the recovery of the glycogen content , the activity of succinate dehydrogenase and alpha - glycerophosphate dehydrogenase as well as increased fluorescence of catecholaminergic nerves in short - term ischemized myocardium ( experimental angina pectoris ) after stimulation of the carotid sinus nerve . - pubmed
The scale of surgical trauma was quantified by measuring interleukin-6 in plasma and exudate from drainage tubes . - pubmed
Though MAC positive sections showed reactivity for S - protein , our observations support the possibility that MAC , either acting directly or indirectly , may be implicated in nerve damage , at least , in lepromatous leprosy patients . - pubmed
Adjuvant hepatic arterial IL-2 and MMC , 5 - FU after curative resection of colorectal liver metastases . - pubmed
BACKGROUND / AIMS : Based on our favorable results of interleukin-2 - based immuno - chemotherapy in the treatment of unresectable liver metastases from colorectal cancer , we utilized this therapy for the prevention of liver recurrence after liver resection . - pubmed
MATERIALS AND METHODS : Eighteen patients with colon cancer metastatic to the liver underwent successful hepatic resection and adjuvant immunochemotherapy that included hepatic arterial infusion of interleukin-2 and mitomycin C , 5 - fluorouracil . - pubmed
However , both treatments are effective in hampering Th2 cell development only if given at a time when IL-4 has been produced for & lt;48 h. At this time after infection , lymph node CD4 + T cells from BALB / c mice no longer respond to IL-12 . - pubmed
This IL-12 unresponsiveness is prevented in mice treated with anti - IL-4 Abs at the initiation of infection . - pubmed
Finally , the inhibition of Th2 development in BALB / c mice treated with anti - IL-4 Abs at the onset of infection results from maintenance of IL-12 responsiveness , since it requires IL-12 . - pubmed
Together , these results reveal a narrow window of time , between 16 h and & lt;48 h after infection , during which IL-4 produced rapidly in BALB / c mice renders T cells unresponsive to IL-12 , allowing their differentiation toward the Th2 phenotype . - pubmed
A post - receptor defect of adenylyl cyclase in severely failing myocardium from children with congenital heart disease . - pubmed
The aim of this study was to determine whether a defect at the post - receptor level of adenylyl cyclase may also contribute to the decreased effectiveness of cAMP - increasing agents in severely failing patients with congenital heart disease . - pubmed
beta - Adrenoceptor - stimulated adenylyl cyclase activity was significantly decreased by 65 % in patients with severe heart failure in comparison to the group of patients with no or mild heart failure . - pubmed
This post - receptor defect of adenylyl cyclase was apparently due to a decrease in the activity of catalytic subunit of adenylyl cyclase as adenylyl cyclase stimulation by forskolin in the presence of Mn2 + which uncouples catalytic subunit from the G proteins , G ( s ) and G ( i ) , was also significantly diminished in the patients with severe heart failure . - pubmed
In summary , the data indicate that a defect at the catalytic subunit of adenylyl cyclase apparently contributes to the decreased effectiveness of cAMP - increasing agents in severely failing patients with congenital heart disease . - pubmed
pylori ) immunoglobulin G ( IgG ) antibody determinations , autoimmune reactivity , infections , allergies , and hyperreactivities were investigated . - pubmed
A diagnosis of adult celiac disease was made in two patients and , additionally , IgA antigliadin antibodies were seen in four patients . - pubmed
The possible role of the proinflammatory cytokines interleukin ( IL )- 1 , tumor necrosis factor - alpha , IL-6 , and IL-8 as modulators of host resistance to bacterial infections is discussed . - pubmed
Interleukin-1 has been effective in various animal models of potentially lethal bacterial infection , even during severe granulocytopenia . - pubmed
Moreover , in subacute and chronic infections IL-1 interferes with microbial outgrowth via mechanisms that have only been partly elucidated . - pubmed
RESULTS : Our results show that ( a ) SCE and HFC values in occupationally exposed nurses do not differ from controls , ( b ) patients with newly diagnosed cancer or following chemotherapy show a number of SCE comparable to those of healthy donors , but a significantly different percentage of HFC , ( c ) cigarette smokers of all categories studied show higher frequencies of SCE and HFC as compared to nonsmokers , but the differences are not statistically significant , ( d ) the mutation frequency at the TCR locus in oncology nurses is higher , but not significantly different from the frequency in the control group , and ( e ) the increase of mutation frequency is statistically significant and seems to be dose dependent in patients treated with high - dose chemotherapy . - pubmed
CONCLUSIONS : Our data suggest that SCE frequency and HFC percentage are not reliable indicators of exposure to possible mutagenic / carcinogenic effects of antineoplastic drugs ; on the contrary , our observations indicate that anticancer therapy induces somatic mutations at the TCR locus and suggest an association between exposure to cytotoxic agents and the increase in somatic mutations . - pubmed
Similarly , zebrafish one - eyed pinhead ( oep ) mutants that have been rescued partially by mRNA injection display heterotaxia , including randomization of heart looping and pancreas location . - pubmed
BACKGROUND : Spurious increases in serum troponins , especially troponin T , have been reported in patients with and without acute myocardial syndromes . - pubmed
METHODS : We studied 78 autopsied patients without clinical myocardial infarction ( MI ) and correlated histologic cardiac findings with antemortem serum creatine kinase ( CK ) , its MB isoenzyme ( CK - MB ) , cardiac troponin I ( cTnI ) , and cardiac troponin T ( cTnT ) . - pubmed
Compared with the no - pathology group , only the MI group was significantly different for cTnI , and the MI and other pathology groups were significantly different for cTnT. - pubmed
For patients with MI , 22 % , 19 % , 48 % , and 65 % had increased CK , CK - MB , cTnI , and cTnT , respectively ; for CHF and other cardiac pathologies combined , the percentages were 28 % , 17 % , 22 % , and 50 % . - pubmed
For patients with increased cTnI , 72 % and 28 % had MI and other myocardial pathologies , respectively ; patients with increased cTnT had 64 % and 36 % , respectively . - pubmed
The second - generation cTnT assay appears to be a more sensitive indicator of MI and other myocardial pathologies than the cTnI assay used in this study . - pubmed
The causative biochemical defect has been identified as a deficiency of the enzyme fatty aldehyde dehydrogenase , a component of fatty alcohol : NAD + oxidoreductase . - pubmed
Interferon - gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice . - pubmed
There have been two previous conflicting reports that the development of T - cell - mediated autoimmune diabetes ( type 1 diabetes ) was respectively unaffected or inhibited in NOD mice genetically deficient in the T - helper ( Th ) 1 cytokine interferon ( IFN )- gamma or the alpha - chain subunit of its receptor . - pubmed
However , despite being unable to respond to the primary Thl cytokine IFN - gamma and having T - cells that produce greatly enhanced levels of IL-4 , NOD.IFNgammaRBnull mice remained highly susceptible to type 1 diabetes . - pubmed
Furthermore , our results indicate that the pathogenicity of diabetogenic T - cells in NOD mice is not dampened by an inability to respond to IFN - gamma and a concurrent shift to greatly enhanced Th2 cytokine production . - pubmed
This finding calls into question whether clinical protocols designed to shift beta - cell autoreactive T - cells from a Thl to Th2 cytokine production profile will truly be safe and efficacious in blocking the development of type 1 diabetes in humans . - pubmed
Somatostatin receptor type 2 gene expression in neuroblastoma , measured by competitive RT - PCR , is related to patient survival and to somatostatin receptor imaging by indium - 111 - pentetreotide . - pubmed
BACKGROUND : We previously reported that human neuroblastoma cell lines and primary neuroblastoma tumors expressed a variable amount of mRNA for type 2 somatostatin ( sst2 ) receptor gene . - pubmed
We found that the lowest level of sst2 mRNA was detected in advanced stages of neuroblastomas ( stage IV ) when compared with the other stages ( P< ; 0.005 ) . - pubmed
Finally we verified that the ex vivo sst2 gene expression in tumor samples was positively related ( P & lt ; 0.01 ) to the in vivo semiquantitative determination of sst2 protein , assessed by 111In - pentetreotide imaging . - pubmed
CONCLUSIONS : Our data indicate that the measurement of sst2 mRNA measurement could represent a relevant tool in the prediction of neuroblastoma outcome , independently from MYCN amplification . - pubmed
Furthermore , work - related symptoms were more prevalent among the exposed workers than among the referents ( eyes 23 % versus 14 % , nose 28 % versus 16 % , nose bleeding 8 % versus 0 % , lower airways 10 % versus 4 % ) , and they were related to the exposure ( adjusted prevalence odds ratios ( POR ) in the highest group 7.7 , 3.6 and 17 , respectively ) and the IgE levels ( POR 4.9 , 3.1 and 5.6 , respectively ) . - pubmed
CONCLUSIONS : In spite of the very low OAA levels in the air and metabolites in the urine , there were high and exposure - related risks of specific IgE and IgG sensitization and of work - related symptoms for the eyes , nose ( especially bleeding ) , and lower airways . - pubmed
EFFECT OF IRON DEFICIENCY ON THE RELATIVE RATES OF SYNTHESIS OF HAEMOGLOBINS A AND E AS STUDIED IN A HEAMOGLOBIN E HETEROZYGOTE . - pubmed
The relationship between expression of p53 / bcl-2 and clinicopathological criteria in cervix squamous cell carcinomas . - pubmed
Low levels of apolipoprotein A1 ( ApoA1 ) and cholesterol in the serum and undetectable levels of high density lipoprotein ( HDL ) and low density lipoprotein ( LDL ) cholesterol in the blood confirmed the diagnosis of TD . - pubmed
Using Medicare claims , we identified patients with diabetes , linked them to practices , and assessed the use of glycohemoglobin ( GHb ) tests , eye examinations , and lipid profiles . - pubmed
The role of regulatory T cells in antigen - induced arthritis : aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25 + T cells . - pubmed
It is now generally accepted that CD4+CD25 + Treg cells play a major role in the prevention of autoimmunity and pathological immune responses . - pubmed
Depletion of CD25 - expressing cells in immunized animals before arthritis induction led to increased cellular and humoral immune responses to the inducing antigen ( methylated bovine serum albumin ; mBSA ) and autoantigens , and to an exacerbation of arthritis , as indicated by clinical ( knee joint swelling ) and histological scores . - pubmed
These data imply a significant role for CD4+CD25 + Treg cells in the control of chronic arthritis . - pubmed
These results indicate that the catalytic domain of AtlA is located at the C terminus , suggesting that further characterization of this domain may provide a means to control cariogenic dental plaque formation . - pubmed
Transplants from partially human leukocyte antigens ( HLA)-incompatible relatives are associated with an increased risk of graft rejection , graft - versus - host disease ( GVHD ) , and lower survival , which are correlated with the degree of disparity . - pubmed
Promoter - hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase ( MTAP ) expression in hepatocellular carcinoma . - pubmed
Here , frequently homozygous deletions occur in several kinds of cancer associated with the loss of tumour suppressor genes as p16 and p15 . - pubmed
The aim of this study was to analyse MTAP expression in hepatocellular carcinoma ( HCC ) and to get an insight into the regulation and functional role of MTAP in hepatocancerogenesis . - pubmed
Compared with primary human hepatocytes MTAP expression was markedly downregulated in three different HCC cell lines as determined by real - time PCR and western blotting . - pubmed
Reduced MTAP - expression was confirmed in vivo in HCC compared with non - cancerous liver tissue on both mRNA and protein levels . - pubmed
To study the functional relevance of the downregulated MTAP expression in HCC , MTAP expression was re - induced in HCC cell lines by stable transfection . - pubmed
In conclusion , our results suggest a functional role of MTAP inactivation in HCC development and invasiveness . - pubmed
Inflammation and injury might be caused by oxidant - mediated expression of inflammatory cytokine interleukin-8 ( IL-8 ) and inflammatory enzymes such as cyclooxtgenase-2 ( COX-2 ) and inducible nitric oxide synthase ( iNOS ) , which were mediated by oxidant - sensitive transcription factors such as nuclear factor - kappaB ( NF - kappaB ) and activator protein-1 ( AP-1 ) , possibly with mitogen activated protein kinase ( MAPK ) activation . - pubmed
Polyamine oxidase and acrolein as novel biochemical markers for diagnosis of cerebral stroke . - pubmed
BACKGROUND AND PURPOSE : We found previously that plasma levels of acrolein ( CH2 = CHCHO ) and spermine oxidase ( SMO ) were well correlated with the degree of severity of chronic renal failure . - pubmed
The aim of this study was to test whether the levels of these 2 markers and of acetylpolyamine oxidase ( AcPAO ) were increased in the plasma of stroke patients . - pubmed
METHODS : The activity of AcPAO and SMO and the level of protein - conjugated acrolein in plasma of the stroke patients and normal subjects were measured by high - performance liquid chromatography and ELISA , respectively . - pubmed
The size of stroke was nearly parallel with the multiplied value of acrolein and total polyamine oxidase ( AcPAO plus SMO ) . - pubmed
Furthermore , stroke was confirmed by MRI in a number of mildly symptomatic patients ( 11 cases ) who had increased levels of total polyamine oxidase and acrolein . - pubmed
Among apparently normal subjects ( 8 cases ) who had high values of acroleinxtotal polyamine oxidase , stroke was found in 4 cases by MRI . - pubmed
The use of chemotherapy with anti - CD20 monoclonal antibody led to complete clinical remission of lymphoma . - pubmed
Complete lack of expression of WASP carries a greater risk for severe infections , bleeding , or malignancy development in WAS . - pubmed
However , rare patients with residual expression of mutated WASP , like this patient , still may develop lymphomas . - pubmed
The results suggest that sigma1 receptors play an important role against retinal damage , even though sigma2 receptor involvement can not be excluded . - pubmed
A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria . - pubmed
Several progeroid disorders are caused by mutations that lead to the accumulation of a lipid - modified ( farnesylated ) form of prelamin A , a protein that contributes to the structural scaffolding for the cell nucleus . - pubmed
coli O157 antiserum , vero cell cytotoxicity assay to detect verocytotoxin ( VT ) and heat labile toxin ( LT ) production , the polymerase chain reaction ( PCR ) to detect VT genes , and the dry spot test to screen for E. - pubmed
Cytotoxic T lymphocyte - associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children . - pubmed
The gene encoding CTLA-4 is a candidate gene for conferring susceptibility to allergic disease . - pubmed
The purpose of this study was to evaluate the potential effects of CTLA-4 gene polymorphisms in Korean children on asthma . - pubmed
As a result , allele and genotype frequencies of the CTLA-4 exon 1 + 49 G & gt ; A polymorphism were different to some extent between the atopic asthma children and the controls with P<0.05 , which did not reach statistical significance after the correction of multiple comparisons . - pubmed
Polymorphisms in the CTLA-4 gene likely confer susceptibility to atopic asthma in Korean children . - pubmed
In multivariable analyses and adjusting for established risk factors and additionally for glomerular filtration rate and for hemoglobin , serum albumin , proteinuria , and C - reactive protein levels , a higher level of serum phosphorus was associated with an increased CVD risk in a continuous fashion ( adjusted hazard ratio per increment of milligrams per deciliter , 1.31 ; 95 % confidence interval , 1.05 - 1.63 ; P=.02 ; P value for trend across quartiles = .004 ) . - pubmed
PURPOSE : Increased epidermal growth factor receptor ( EGFR ) expression may promote breast cancer resistance to endocrine therapy . - pubmed
PATIENTS AND METHODS : Postmenopausal women with stage I to IIIB hormone receptor - positive early breast cancer received anastrozole 1 mg daily for 16 weeks and were randomly assigned at a ratio of 2:5:5 to receive , in addition , gefitinib 250 mg / d orally for 16 weeks : placebo 1 tablet / d orally for 2 weeks and then gefitinib for 14 weeks or placebo for 16 weeks . - pubmed
Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter : implications for Alzheimer disease . - pubmed
Amyloid beta - peptide ( Abeta ) accumulation leads to neurodegeneration and Alzheimer disease ; however , amyloid metabolism is a dynamic process and enzymic mechanisms exist for Abeta removal . - pubmed
TLR9 activation is important for the maintenance of mycobacteria - elicited pulmonary granulomatous responses , hallmarks of protective immune responses following mycobacterial infection . - pubmed
Passively immunizing WT mice with neutralizing antibodies specific for dll4 during granuloma formation resulted in larger granulomas and lower levels of Th17 - related cytokines . - pubmed
Furthermore , TLR9 seems to be required for optimal dll4 expression and the regulation of Mycobacterium antigen - elicited granuloma formation in mice . - pubmed
Our results showed that in vitro digestion of cooked eggs could generate a number of potent ACE inhibitory peptides which may have implications for cardiovascular disease prevention , including hypertension . - pubmed
RESULTS : Significant associations were found between caries , age and specific individual submandibular / sublingual salivary proteins ( lactoferrin , albumin , lysozyme , mucin and cystatin ) and specific inorganic constituents ( K+ , Ca2 + , Na+ and Cl- ) . - pubmed
Currently , vasopressin and terlipressin are most commonly used to stimulate V1R in vasodilatory shock and cardiac arrest , while desmopressin , a synthetic analogue of vasopressin , acts on V2R ; but new molecules are becoming available in the treatment of inappropriate antidiuretic hormone ( ADH ) secretion . - pubmed
Immunohistochemical staining of malignant Brenner tumor often demonstrates positivity for uroplakin III , thrombomodulin and cytokeratin 7 and negativity to cytokeratin 20 . - pubmed
Risk - reducing salpingo - oophorectomy ( RRSO ) is the most definitive surgical intervention for ovarian cancer risk reduction among BRCA1 / 2 mutation carriers . - pubmed
Detection of EGFR mutations with mutation - specific antibodies in stage IV non - small - cell lung cancer . - pubmed
BACKGROUND : Immunohistochemistry ( IHC ) with mutation - specific antibodies may be an ancillary method of detecting EGFR mutations in lung cancer patients . - pubmed
METHODS : EGFR mutation status was analyzed by DNA assays , and compared with IHC results in five non - small - cell lung cancer ( NSCLC ) cell lines and tumor samples from 78 stage IV NSCLC patients . - pubmed
RESULTS : IHC correctly identified del 19 in the H1650 and PC9 cell lines , L858R in H1975 , and wild - type EGFR in H460 and A549 , as well as wild - type EGFR in tumor samples from 22 patients . - pubmed
CONCLUSIONS : IHC with mutation - specific mAbs against EGFR is a promising method for detecting EGFR mutations in NSCLC patients . - pubmed
However these mAbs should be validated with additional studies to clarify their possible role in routine clinical practice for screening EGFR mutations in NSCLC patients . - pubmed
Multiple observational studies have consistently shown that increased body mass index as well as insulin resistance and increased fasting insulin levels is associated with chronic kidney disease , even after adjustment for related disorders . - pubmed
These compounds may be useful for behavioral pharmacology studies on the role of D ( 2 )- like dopamine receptors in neuropsychiatric and neurological disorders . - pubmed
OBJECTIVES : Beryllium sensitisation ( BeS ) and chronic beryllium disease ( CBD ) are caused by exposure to beryllium with susceptibility affected by at least one well - studied genetic host factor , a glutamic acid residue at position 69 ( E69 ) of the HLA - DPbeta chain ( DPbetaE69 ) . - pubmed
Involvement of p53 R72P polymorphism in the association of MDM2 - SNP309 with breast cancer . - pubmed
The allelic variant MDM2 - SNP309 ( T>G ) has been suggested to influence cancer development , but the clinical correlation between the risk allele and breast cancer remains controversial . - pubmed
In this study , we investigated whether MDM2 - SNP309 is associated with p53 R72P genetic polymorphism for the risk of breast cancer development in Asian Taiwanese , which has not been well - studied in this regard . - pubmed
Two hundred and fifty - five patients and 324 cancer - free controls were included , and we found that the MDM2 - SNP309 TG and GG genotypes displayed marginally increased risks of breast cancer ( GG vs. TT : OR = 1.7 , 95 % CI = 0.93 to 3.09 ; TG + TT vs. TT : OR = 1.57 , 95 % CI = 0.98 to 2.56 ) . - pubmed
The breast cancer risk associated with MDM2 - SNP309 was enhanced after stratification for the homozygous GG genotype at p53 codon 72 representing the Arg form of this genotype ( GG vs. TT : OR = 3.7 , 95 % CI = 1.144 to 12.02 ; TG + GG vs. TT : OR = 2.7 , 95 % CI = 1.027 to 6.895 ) . - pubmed
Moreover , the G - allele of MDM2 - SNP309 exhibited a stronger capacity than the T - allele to drive the full - length P2 promoter of the MDM2 gene in several human cell lines , suggesting that the association between MDM2 - SNP309 and breast cancer is likely multifactorial rather than due to inconsistent gene expression in different cancer sources . - pubmed
OBJECTIVE : To investigate the influence of Bushenguchiwan on expression of matrix metalloproteinase-13 ( MMP-13 ) in periodontium of rats with experimental periodontitis . - pubmed
RESULTS : MMP-13 was intensely positive in gingival epithelial cells and periodontal fibroblasts in periodontitis models and negative in normal rat periodontal tissues . - pubmed
Antibodies to lytic infection proteins in lymphocryptovirus - infected rhesus macaques : a model for humoral immune responses to epstein - barr virus infection . - pubmed
Serum antibodies to rhBARF1 were frequently detected in healthy rhLCV - infected macaques , but in humans , anti - BARF1 antibodies have been reported primarily in patients with EBV - positive nasopharyngeal carcinoma ( NPC ) . - pubmed
The macaque data accurately predicted that serum antibodies against BARF1 are a normal response to EBV infection when human serum samples are analyzed . - pubmed
Genetic alterations of ALK are associated with a number of cancers , including anaplastic large cell lymphoma ( ALCL ) and a subset of non - small cell lung cancer ( NSCLC ) . - pubmed
Along the same way shown by imatinib in chronic myeloid leukemia , compounds that selectively target ALK are bringing a revolution in the treatment of ALK - positive tumors . - pubmed
Familial Adenomatous Polyposis ( FAP ) due to loss of the APC gene and Lynch syndrome or Hereditary Non - Polyposis Colon Cancer ( HNPCC ) due to breakdown in MisMatch Repair are the principal syndromes of broader interest and both have been the subject of chemoprevention trials . - pubmed
There has been a longstanding interest in non - steroidal anti inflammatories in FAP where trials have shown regression of polyps with the " pro drug"sulindac and the selective COX2 inhibitors though impact on long - term cancer risk is not confirmed . - pubmed
We found 3 genes SORCS1 , AMPD1 , and PPARalpha to be associated with the development of both IGT and IFG , while 5 genes AMPD2 , PRKAA2 , C5 , TCF7L2 , and ITR with the IGT mechanism only and 6 genes CAPN10 , IL4 , NOS3 , CD14 , GCG , and SORT1 with the IFG mechanism only . - pubmed
Mice lacking Klotho or fibroblast growth factor 23 ( FGF23 ) exhibit a premature aging syndrome associated with abnormal mineral metabolism characterized by hyperphosphatemia , hypercalcemia , and hypervitaminosis D. - pubmed
Hyperphsophatemia , decreased Klotho expression , and aging - like symptoms are often manifested in patients with chronic kidney disease ( CKD ) . - pubmed
Cytokines , which usually serve as signals between neighboring cells , are involved in essentially every important biological process , including cell proliferation , inflammation , immunity , migration , fibrosis , tissue repair , and angiogenesis . - pubmed
Cytokines and chemokines are multifunctional mediators that can direct the recruitment of leukocytes to sites of inflammation , promote the process , enhance immune responses , and promote stem cell survival , development , and homeostasis . - pubmed
Recent findings concerning the statistical laws of behavioral organization shared between healthy humans and wild - type mice ( WT ) and their alterations in human depression patients and circadian clock gene ( Period 2 ; Per2 ) mutant mice indicate that clock genes play functional roles in intermittent , ultradian locomotor dynamics . - pubmed
Furthermore , based on a stochastic priority queuing model , we explained the power - law nature of resting period distributions , as well as its alterations shared with human depressive patients and Per2 mutant mice . - pubmed
Antitumor activity of the selective pan - RAF inhibitor TAK-632 in BRAF inhibitor - resistant melanoma . - pubmed
The mitogen - activated protein kinase ( MAPK ) pathway is particularly important for the survival and proliferation of melanoma cells . - pubmed
Somatic mutations in BRAF and NRAS are frequently observed in melanoma . - pubmed
Recently , the BRAF inhibitors vemurafenib and dabrafenib have emerged as promising agents for the treatment of melanoma patients with BRAF - activating mutations . - pubmed
However , as BRAF inhibitors induce RAF paradoxical activation via RAF dimerization in BRAF wild - type cells , rapid emergence of acquired resistance and secondary skin tumors as well as presence of few effective treatment options for melanoma bearing wild - type BRAF ( including NRAS - mutant melanoma ) are clinical concerns . - pubmed
As a result , TAK-632 demonstrates potent antiproliferative effects both on NRAS - mutated melanoma cells and BRAF - mutated melanoma cells with acquired resistance to BRAF inhibitors through NRAS mutation or BRAF truncation . - pubmed
Our findings characterize the unique features of TAK-632 as a pan - RAF inhibitor and provide rationale for its further investigation in NRAS - mutated melanoma and a subset of BRAF - mutated melanomas refractory to BRAF inhibitors . - pubmed
There is evidence that skeletal muscle adiponectin resistance may develop in obesity and play a role in the pathogenesis of diabetes . - pubmed
Huntington ' s disease ( HD ) is the most common polyglutamine neurodegenerative disorder in humans , and is caused by a mutation of an unstable expansion of CAG repeats within the coding region of the HD gene , which expresses the protein huntingtin . - pubmed
The androgen receptor ( AR ) is a ligand - activated transcription factor that is essential for prostate cancer development . - pubmed
MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1 . - pubmed
In this article , we demonstrate that increasing plasma MG to levels observed in diabetic mice either using an exogenous source ( 1 % in drinking water ) or generated following inhibition , its primary clearance enzyme , glyoxalase-1 ( with 50 mg / kg IP bromobenzyl - glutathione cyclopentyl diester every second day ) , was able to increase vascular adhesion and augment atherogenesis in euglycemic apolipoprotein E knockout mice to a similar magnitude as that observed in hyperglycemic mice with diabetes . - pubmed
The effects of MG appear partly mediated by activation of the receptor for advanced glycation end products ( RAGE ) , as deletion of RAGE was able to reduce inflammation and atherogenesis associated with MG exposure . - pubmed
However , RAGE deletion did not completely prevent inflammation or vascular damage , possibly because the induction of mitochondrial oxidative stress by dicarbonyls also contributes to inflammation and atherogenesis . - pubmed
Such data would suggest that a synergistic combination of RAGE antagonism and antioxidants may offer the greatest utility for the prevention and management of diabetic vascular complications . - pubmed
Accelerated , spleen - based titration of variant Creutzfeldt - Jakob disease infectivity in transgenic mice expressing human prion protein with sensitivity comparable to that of survival time bioassay . - pubmed
To address this limitation , we tested the potential of a transgenic mouse line overexpressing human prion protein ( PrP ) , which was previously reported to propagate vCJD prions . - pubmed
Endpoint titration of vCJD infectivity in different tissues was evaluated by two different methods : ( i ) the " classical " bioassay , based on the appearance of clinical symptoms and the detection of pathological prion protein in tissues of the inoculated mouse , and ( ii ) a shortened bioassay based on the detection of the protein in the mouse spleen at defined time points . - pubmed
Also , teratomas were not seen in mice with severe combined immunodeficiency syndrome ( SCID ) that received a transplantation of hfMSCs with hTERT activity . - pubmed
Inflammatory bowel disease was associated with significantly higher levels of fibrinogen , PT , factor V , factor VIII , plasminogen and thrombocyte . - pubmed
Protein S , fibrinogen , plasminogen and thrombocyte levels were associated with disease activity , depending on the type of the disease ( Crohn ' s disease or ulcerative colitis ) . - pubmed
Extrasynaptic glutamate release through cystine / glutamate antiporter contributes to ischemic damage . - pubmed
During brain ischemia , an excessive release of glutamate triggers neuronal death through the overactivation of NMDA receptors ( NMDARs ) ; however , the underlying pathways that alter glutamate homeostasis and whether synaptic or extrasynaptic sites are responsible for excess glutamate remain controversial . - pubmed
In contrast , pharmacological inhibition of the cystine / glutamate antiporter dramatically attenuated ischemia - gated currents and cell death after OGD . - pubmed
Hedgehog pathway mutations in T - cell acute lymphoblastic leukemia . - pubmed
CE1 and CE2 HF exhibited comparable spotting patterns , but CE2 HF harbored greater amounts of EgAgB and EgAg5 complexes . - pubmed
Patient sera of alveolar echinococcosis ( AE ) cross - reacted with diverse EgAgB isoforms ( 36 % ) . - pubmed
EgAg5 and cathepsin B also demonstrated cross - reactions with sera from neurocysticercosis and sparganosis . - pubmed
Reslizumab , a neutralizing anti - IL-5 monoclonal antibody , is a promising adjunctive treatment for severe eosinophilic asthma . - pubmed
In addition , our in vitro pilot study with 3T3 - L1 cells showed that vitexin , the functional chemical in MBT , inhibited inflammation - induced lipogenesis with significantly lower amounts of IL-6 and MCP-1 after 14 days of vitexin treatment . - pubmed
After two serial passages in vivo , SHIV ( SHIV-89.6P ) induces CD4 lymphopenia and an AIDS - like disease with wasting and opportunistic infections . - pubmed
We found especially high immune activation , low IFN - alpha expression , and distinctive cytokine expression profiles in the infected and dead ( ID ) group of monkeys , while there was only few change in the CD4(+ ) T counts and distribution of T cell subsets in the ID group monkeys . - pubmed
These results suggest that SHIV89.6 infections have pathogenic potential in CRMs and that high immune activation and abnormal expression of cytokines contribute to death of SHIV89.6 - infected CRMs . - pubmed
Identification of IL13 C1923 T as a Single Nucleotide Polymorphism for Asthma in Children from Mauritius . - pubmed
However , the frequency of IL13 C1923 T TT in the asthma group was significantly higher than in the control group ( odds ratio=2.119 , p=0.033 ) suggesting that carriers of IL13 C1923 T TT in the Mauritian population may have a more significant risk of developing asthma . - pubmed
IL13 C1923 T TT has been detected to be the susceptible genotype and may have a significant effect on the pathogenesis of childhood asthma in the Mauritian population . - pubmed
Histological findings showed that rutin administration significantly reduced renal interstitial injury and suppressed interstitial collagen deposits in UUO rats . - pubmed
Taken together , the renoprotective effects of rutin in obstructive nephropathy were likely due to anti - inflammatory effects and inhibition of TGF - beta1 / Smad3 signaling . - pubmed
BRAF(V600E ) Mutation is Associated with Decreased Disease - Free Survival in Papillary Thyroid Cancer . - pubmed
BACKGROUND : The BRAF ( V600E ) mutation is a recognised molecular marker in papillary thyroid cancer ( PTC ) , reported incidence from 30 to 80 % . - pubmed
Previous studies have reported conflicting data regarding the impact of BRAF(V600E ) on clinicopathological features of PTC . - pubmed
The study aims to determine whether BRAF(V600E ) is useful as a prognostic biomarker in PTC . - pubmed
RESULTS : 496 patients with PTC were included , and 309 ( 62 % ) were BRAF(V600E ) positive . - pubmed
Tumour size was similar for BRAF(V600E)-positive and -negative tumours ( 21.3 vs. 23.2 mm , p = 0.23 ) . - pubmed
BRAF(V600E)-positive PTCs had a higher rate of disease recurrence ( 12.9 vs. 5.6 % , p = 0.004 ) , lymph node metastasis ( 44 vs. 29.4 % , p = 0.004 ) and extra - thyroidal extension ( 44 vs. 22 % , p & lt ; 0.001 ) . - pubmed
Five - year disease - free survival was 89.6 % for BRAF(V600E ) positive and 96.3 % for negative tumours , p & lt ; 0.001 . - pubmed
CONCLUSION : BRAF(V600E ) in PTC predicts an increased risk of lymph node metastasis , extra - thyroidal extension and reduced disease - free survival . - pubmed
In EoE cases refractory to conventional treatments , newer therapies targeting inflammatory mediators and cytokines are on the horizon . - pubmed
A role for pulmonary endothelial cells in the orchestration of cytokine production and leukocyte recruitment during influenza virus infection , leading to severe lung damage , has been recently identified . - pubmed
IFITM3 knockdown by small interfering RNA ( siRNA ) could partially rescue H1N1 virus infection in HULEC , suggesting IFITM3 proteins were involved in blocking human influenza virus infection in endothelial cells . - pubmed
We show that human influenza virus infection is blocked during the early stages of virus entry , which is likely due to the relatively high expression of the host antiviral factors IFITMs ( interferon - induced transmembrane proteins ) located in membrane - bound compartments inside cells . - pubmed
Expression of Carbonic Anhydrase I in Motor Neurons and Alterations in ALS . - pubmed
Helicobacter pylori vacA s1m1 genotype but not cagA or babA2 increase the risk of ulcer and gastric cancer in patients from Southern Mexico . - pubmed
The objectives were to determine the frequency of infection and distribution of the vacA , cagA and babA2 genotypes of H. - pubmed
babA2 was associated with gastric cancer , and cagA was not associated with the diagnosis . - pubmed
pylori and the s1m1 genotype were associated with gastric cancer and the s1m1 / cagA+/babA2 + strains predominated in tumor and adjacent tissue . - pubmed
Correction : Oleuropein down - regulated IL-1beta - induced inflammation and oxidative stress in human synovial fibroblast cell line SW982 . - pubmed
Correction for ' Oleuropein down - regulated IL-1beta - induced inflammation and oxidative stress in human synovial fibroblast cell line SW982 ' by Maria Luisa Castejon , et al . - pubmed
In this study , we found that HSP90 was cleaved to a 55kDa protein after treatment with proteasome inhibitors including MG132 in leukemia cells but was not cleaved in other tissue - derived cells . - pubmed
The full functional characterization of bone and striated muscle microcirculatory parameters in non - obese diabetic - severe combined immunodeficiency / y - chain ; NOD - Prkds IL2rg ( NSG ) mice has not yet been reported . - pubmed
Our results showed that high salt intake resulted in higher mean arterial pressure , cardiac hypertrophy as well as increased plasma level of norepinephrine and interleukin ( IL )- 1beta , IL-6 compared with NS rats . - pubmed
FoxR2 promotes glioma proliferation by suppression of the p27 pathway . - pubmed
FoxR2 plays an important role in the development of many human tumors . - pubmed
However , the effects of FoxR2 on tumorigenicity of human glioma remain unclear . - pubmed
In this study , we investigated the roles of FoxR2 in cell proliferation and invasion of glioma . - pubmed
We found that overexpression of FoxR2 promoted the proliferation , migration and invasion of glioma cells . - pubmed
Taken together , these results indicate that upregulation of FoxR2 may confer enhanced tumorigenicity in glioma cells . - pubmed
We evaluated the model of psoriasis and EGFR siRNA treatment ( as spherical nucleic acid nanoparticles ) , phenotypically ( signs of erythema , scaling , inflammation and thickening ) , microscopic evaluation of cell proliferation and immunohistochemically evaluation of CD3 , CD4 , and CD8 markers . - pubmed
Transforming growth factor - beta signaling in systemic sclerosis . - pubmed
Transforming growth factor beta ( TGF - beta ) has been identified as a regulator of pathological fibrogenesis in SSc . - pubmed
Understanding the essential role TGF - beta pathways play in the pathology of systemic sclerosis could provide a potential outlet for treatment and a better understanding of this severe disease . - pubmed
CD44 knockdown in cancer diminished glutathione , but not HT in tumours . - pubmed
Mechanisms whereby tumours sustained HT under CD44 - knockdown conditions include upregulation of PHGDH , PSAT1 and PSPH that drove glycolysis - dependent activation of serine / glycine - cleavage systems to provide one - methyl group for HT synthesis . - pubmed
Of interest are three genes , eEF1A1 , CASK , and PSMD6 that are linked to PARK2 activity in the cell and thereby form attractive candidate genes for understanding PD . - pubmed
Interferons in Traumatic Brain and Spinal Cord Injury : Current Evidence for Translational Application . - pubmed
This review article provides a general perspective of the experimental and clinical work surrounding the role of type - I , type - II , and type - III interferons ( IFNs ) in the pathophysiology of brain and spinal cord injury . - pubmed
Since IFNs are themselves well - known therapeutic targets ( as well as pharmacological agents ) , and anti - IFNs monoclonal antibodies are being tested in clinical trials , it is timely to review the basis for the repurposing of these agents for the treatment of brain and spinal cord traumatic injury . - pubmed
Experimental evidence suggests that IFN - alpha may play a detrimental role in brain trauma , enhancing the pro - inflammatory response while keeping in check astrocyte proliferation ; converging evidence from genetic models and neutralization by monoclonal antibodies suggests that limiting IFN - alpha actions in acute trauma may be a suitable therapeutic strategy . - pubmed
Effects of IFN - beta administration in spinal cord and brain trauma have been reported but remain unclear or limited in effect . - pubmed
Despite the involvement in the inflammatory response , the role of IFN - gamma remains controversial : although IFN - gamma appears to improve the outcome of traumatic spinal cord injury , genetic models have produced either beneficial or detrimental results . - pubmed
To date , IFN - alpha appears to most promising target for drug repurposing , and monoclonal antibodies anti IFN - alpha or its receptor may find appropriate use in the treatment of acute brain or spinal cord injury . - pubmed
There has been an explosion in our knowledge of autoimmune encephalitis associated with antibodies to neuronal cell surface antigens , and two of the most common forms , anti - NMDA receptor encephalitis and anti - LGI1 encephalitis , are typically associated with distinctive clinical features . - pubmed
Type - I interferons ( IFN - I ) are used as common antiviral drugs for a range of viral diseases in clinic . - pubmed
Interestingly , viral infection upregulates USP7 and therefore facilitates viral immune evasion . - pubmed
Erythropoiesis defect observed in STAT3 GOF patients with severe anaemia . - pubmed
STAT3 mediates inflammation and modulates immunity . - pubmed
Commentary of the impact of obesity and puberty on insulin sensitivity . - pubmed
Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing . - pubmed
Background : Sam68 , an RNA - binding protein , exerts oncogenic functions in several types of cancer . - pubmed
However , the specific functions and mechanisms of Sam68 in colorectal cancer ( CRC ) had not been previously clarified . - pubmed
Pyruvate kinase muscle ( PKM ) 2 is the key rate - limiting enzyme in glycolysis , and PKM2 maintains the glycolysis - dominant energy metabolism in most cancer cells . - pubmed
Results : Gain - of - function and loss - of - function studies showed that ectopic expression of Sam68 promoted glycolysis and cell proliferation in CRC cells , whereas Sam68 knockdown inhibited glycolysis and cell proliferation . - pubmed
Sam68 significantly promoted cell proliferation and caused a decrease of PKM1 / PKM2 ratio , resulting in the metabolism of glucose switched from oxidative phosphorylation to glycolysis in CRC cells . - pubmed
Conclusions : These findings suggested that Sam68 affected cell growth and glycolysis pathway by regulating the alternative splicing and expression of PKM2 in CRC . - pubmed
Childhood trauma , psychiatric disorders , and criminality in women : Associations with serum levels of brain - derived neurotrophic factor . - pubmed
The aim of this study was to determine whether five childhood trauma subtypes - physical abuse , sexual abuse , emotional abuse , physical neglect , and emotional neglect - are associated with adult psychiatric disorders , BDNF levels , and criminality among incarcerated women . - pubmed
Lower BDNF levels were associated with emotional abuse in the forensic group as well as with sexual abuse in the healthy control group . - pubmed
After multinomial logistic regression , lower levels of BDNF , higher levels of emotional abuse and the presence of familial offense were considered factors related to clinical psychiatric group . - pubmed
The results of this study underscore the idea that BDNF may be an important factor related to the development of diseases and criminality in women who are victims of childhood trauma , becoming a possible biological marker . - pubmed
[ Detecting Large Germline Rearrangements of BRCA1 by Next Generation Tumor Sequencing ] . - pubmed
A majority of BRCA1 / 2 ( BRCA ) pathogenic variants ( PVs ) are single nucleotide substitutions or small insertions / deletions . - pubmed
The aim of this study was to validate the Next Generation Tumor Sequencing ( NGTS ) technology to detect various gLGRs of BRCA1 locus in surgical tumor tissue samples . - pubmed
In this study , seven different BRCA1 gLGRs , previously found in high - grade serous ovarian cancers ( HGSOC ) patients , were detected in tumor samples collected from the patients at a time of HGSOC surgery . - pubmed
This study demonstrated that NGS can accurately detect BRCA1 gLGRs in primary tumors , suggesting that gLGR evaluation in BRCA1 locus should be performed in cases when the screening for BRCA alterations starts from tumor instead of blood . - pubmed
NGS sequencing of tumor samples may become the preferred method to detect both somatic and germline gLGRs in BRCA - encoding loci . - pubmed
In a multivariable regression analysis , prematurity , male sex , congenital heart disease , sepsis , ventilator support , vasopressor receipt , central venous catheter , invasive procedures , and receipt of erythropoietin were associated with increased risk of thrombosis , while Black race and Hispanic ethnicity were associated with reduced risk . - pubmed
The insulin receptor in myotonic dystrophy . - pubmed
Insulin binding was studied using circulating monocytes obtained from seven patients with myotonic dystrophy and seven control subjects . - pubmed
These results suggest that no abnormality exists in the insulin receptor in myotonic dystrophy . - pubmed
Plasma renin activity was measured in 14 of the patients with hypertension . - pubmed
Inhibitors to interleukin 1 and tumor necrosis factor may have therapeutic potential in conditions such as inflammatory arthritis , diabetes mellitus , disseminated intravascular coagulopathy and septic shock . - pubmed
The ability to modulate host defenses with cytokines and cytokine antagonists may also have applications in the fields of transplantation , oncohematology and immunodeficiency . - pubmed
Serum aminoterminal propeptide of type III procollagen in systemic sclerosis . - pubmed
Fifty - seven patients with systemic sclerosis were investigated for connective tissue turn - over related to type III collagen . - pubmed
Sera from 13 patients with diffuse cutaneous systemic sclerosis and 44 patients with limited cutaneous systemic sclerosis were analysed for aminoterminal propeptide of type III procollagen ( PIIINP ) by a radioimmunoassay based on human propeptide . - pubmed
Increased levels of PIIINP in serum correlated with skin involvement and the clinical course . - pubmed
All patients with diffuse cutaneous systemic sclerosis had levels above the normal range , and in limited cutaneous systemic sclerosis elevated PIIINP levels seemed to be correlated with rapid progression and with extension of lesions . - pubmed
Serum PIIINP may be utilized as a marker of type III collagen fibrogenesis in systemic sclerosis and be of prognostic value . - pubmed
PIIINP may also be of use in the differential diagnosis between diffuse cutaneous systemic sclerosis and scleredema . - pubmed
The data developed in this study should be applicable to the study of patients with hypertension due to apparent mineralocorticoid excess , a deficiency in 11 - HSD activity . - pubmed
Furthermore , two murine models appear relevant to the study of late HIV-1 infection and suggest a role for CD8 + T cells in the prevention of symptomatic AIDS . - pubmed
Geographical distribution of subclinical autoimmune thyroid disease in Britain : a study using highly sensitive direct assays for autoantibodies to thyroglobulin and thyroid peroxidase . - pubmed
Excluding cases of overt thyroid disease ( biochemically hypo- or hyperthyroid with thyroid antibodies ) , the overall prevalences of the antibodies in sera from the 698 female blood donors were 17.8 % for thyroglobulin antibody and 17.8 % for thyroid peroxidase antibody . - pubmed
In contrast , the prevalences of thyroglobulin antibody and thyroid peroxidase antibody were 41 and 43 % , respectively , in the 117 female relatives of 18 probands with autoimmune thyroid disease , but the highest prevalences were observed in groups of women patients with Graves ' disease ( N = 39 ) or Hashimoto ' s disease ( N = 39 ) ( 51 , and 97 % for thyroglobulin antibody , respectively , and 72 and 97 % for thyroid peroxidase antibody , respectively ) . - pubmed
In contrast , in a patient with hypercortisolism and a preserved circadian rhythm of cortisol levels , we found the minimum of IL-1 production at 4:00 p.m. , 8 hours after the maximum cortisol level was reached . - pubmed
Furthermore , in 7 patients with sarcoidosis both spontaneous and LPS - induced IL-1 production of isolated monocytes were significantly decreased 8 hours after the first injection of MP ( 1 mg / kg bw i.v . ) - pubmed
It is suggested that the hypotensive action of timolol on intraocular pressure results from structural and functional changes induced on the plasma membranes of the iris - ciliary body and trabecular meshwork by the thiadiazole group of the molecule , and , also , from the occupation of the adrenergic receptors of the iris - ciliary body by the tert - butylamino-2 - hydroxypropoxy part of the compound . - pubmed
Intravenous immunoglobulin therapy for idiopathic thrombocytopenic purpura and other immune - related disorders : review and update of our experiences . - pubmed
The former was recently confirmed by the observation that serum and platelet eluates of patients with ITP bind to normal platelets , but not to Glanzmann 's thrombasthenic platelets which are deficient in glycoproteins IIb and IIIa . - pubmed
The heterogeneity of ITP is also reflected in the difference in response to immunoglobulin prepared for intravenous administration ( IVIG ) treatment . - pubmed
Diagnostic value of a single serum thyroglobulin determination on and off thyroid suppressive therapy in the follow - up of patients with differentiated thyroid cancer . - pubmed
To assess the significance of a single serum thyroglobulin ( Tg ) determination on and off thyroid suppressive therapy , serum Tg measurements have been performed in 349 serum samples from 82 patients with differentiated thyroid cancer . - pubmed
Serum Tg was undetectable in sera from patients with no evidence of thyroid residue or metastatic disease in all but one ( 1.7 % ) of 59 samples on and three ( 5.4 % ) of 56 samples off suppressive therapy . - pubmed
We describe an equilibrium assay for measuring release of plasminogen activator form blood - vessel walls and report data from 125 individuals free of overt thromboembolic disease . - pubmed
Excess human plasminogen is added to the euglobulin fraction of plasma obtained before and after venous occlusion at mean systolic pressure . - pubmed
Both antiviral and nonantiviral effects of interferon are accentuated in cell culture systems utilizing DS tissue , presumably as a consequence of the localization of the interferon gene(s ) on chromosome 21 . - pubmed
A study of dosage wastage in insulin - treated diabetics ] . - pubmed
Effect of the aqueous extract of Cinnamomum Cassia ( CCAq ) on experimental glomerulonephritis was studied and compared with that of cobra venom factor ( CoVF ) . - pubmed
These results suggest that intravenous adrenomedullin exerts a hypotensive action that is associated with the attenuated reflex - mediated sympathetic activation . - pubmed
The production of macrophage inflammatory protein-1 alpha ( MIP-1 alpha ) , a chemotactic cytokine which has an important role in vivo for the recruitment of leukocytes to a site of inflammation , was also significantly inhibited during peak production on Days 4 and 5 of the MLR assay . - pubmed
To these finding , lesions of the dorsal / ventral hippocampus and amygdala in aged animals resulted in significantly increased TSH secretion , while results of septal lesions were not significant . - pubmed
Warfarin derivatives exert both their embryopathic and their fetopathic effects via pharmacologic action : inhibition of gamma carboxylation of osteocalcin and a similar carboxylation of the vitamin K dependent clotting factors . - pubmed
Meanwhile , serum transaminases ( GOT and GPT ) activities were significantly increased by CCl4 administration , indicating that liver injury is induced . - pubmed
The present study demonstrates that hepatic regucalcin is released into the serum of rats administered orally CCl4 , suggesting that the estimation of serum regucalcin is a useful tool for diagnosis of liver injury . - pubmed
Interestingly , reduced numbers of macrophages with the phenotype of antigen presenting cells ( monoclonal antibodies RFD1 + RFD7- ) were recorded in the subjects with bronchial hyperresponsiveness , who also had a significant increase in the proportion of RFD1 + RFD7 + suppressor macrophages . - pubmed
The measurement of mare colostral and foal serum IgG as well as the paramunisation of neonatal and weaned foals are important factors in the prevention of infectious diseases . - pubmed
Differential islet cell expression of two glutamate decarboxylases , both autoantigens in diabetes . - pubmed
Recombinant interferon gamma for the therapy of immunological and oncological diseases . - pubmed
In addition , the inhibitory activity of isothiocyanates for PROD correlated with the previously demonstrated tumor inhibitory potency in ( 4 - methylnitrosamino )- 1 -( 3 - pyridyl )- 1 - butanone ( NNK ) induced A / J mouse lung tumor bioassays , which supports earlier findings that P450 2B1 is one of the major isozymes involved in NNK activation and that inhibition of this isozyme is an important mechanism for the chemopreventive activity of isothiocyanates . - pubmed
The NF1 gene product , neurofibromin , displays partial homology to GTPase - activating protein ( GAP ) . - pubmed
The mutations reported in this study therefore provide further material for the functional analysis of neurofibromin as well as an insight into the mutational spectrum of the NF1 GRD . - pubmed
Because itraconazole , a widely used mycotic , is a potent inhibitor of CYP3A4 , we wanted to study a possible interaction between oxybutynin and itraconazole . - pubmed
Leukocyte adhesion deficiency type 1 ( LAD-1)/variant . - pubmed
A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins . - pubmed
LAD-1 is characterized by the absence of the beta2 integrins ( CD11 / CD18 ) on leukocytes . - pubmed
During follow - up , a bleeding tendency related to decreased beta3 activation became clinically apparent , different from previously described cellular adhesion molecule variants . - pubmed
Therefore , this is the first well - documented case of a clinical combined immunodeficiency syndrome that results from nonfunctional CD11 / CD18 molecules , and thus designated LAD-1/ variant . - pubmed
The quality - of - life effects of interferon beta-1b in multiple sclerosis . - pubmed
BACKGROUND : A recombinant form of interferon beta-1b ( Betaseron ) was given Food and Drug Administration approval for use in the treatment of relapsing - remitting multiple sclerosis in 1993 based on a documented reduction in exacerbation rate . - pubmed
OBJECTIVES : To evaluate a recombinant form of interferon beta-1b in the treatment of relapsing - remitting multiple sclerosis and to discuss treatment trade - offs and comprehensive quality - of - life ( QOL ) outcomes . - pubmed
METHODS : We present a randomized evaluation of treatment with a recombinant form of interferon beta-1b in 79 patients with multiple sclerosis who participated in a random allocation lottery and were followed up for 12 months , during which data on QOL and clinical outcomes were collected . - pubmed
These results suggest that ICM - derived antibodies can be used to map surface - accessible epitopes on MSP-1 and that the recombinant fragments with which they react are appropriate candidates for further evaluation as components of a malaria vaccine . - pubmed
Insulin dose adjustment by diabetes specialist nurses is common practice but its legality is questionable . - pubmed
These enzymatic pathways may contribute to a complex relationship between the hypertensive actions of Ang II and various vasodepressor peptides from either the renin - angiotensin system or other peptide systems . - pubmed
administration , which can be of clinical interest especially in patients with kidney insufficiency who are treated with GLP-1 . - pubmed
Wnt signaling induces GLT-1 expression in rat C6 glioma cells . - pubmed
Because expression of the Wnt-1 protooncogene results in induction of the glial - type glutamate transporter GLAST in PC12 neuron - like cells , we have evaluated the effect of Wnt-1 - induced signaling on glutamate transporter expression in rat C6 glioma cells . - pubmed
Because cytogenetic studies frequently identify chromosome 5 and 17 deletions within a single clone , we searched for allele loss for 5q loci and TP53 gene mutations in the same leukemic samples . - pubmed
Cosegregating deletions of chromosomes 5 and 17 were found to specifically include the 5q13.3 interval between the loci D5S672 and D5S620 / D5S626 , a locus hypothesized to harbor a tumor suppressor gene(1 ) and the TP53 gene on 17p . - pubmed
Our findings are consistent with functional cooperation between a putative tumor suppressor gene at 5q13.3 that contributes toward the progression of early stages of MDS , and the TP53 gene when mutated , causes transformation to AML . - pubmed
The meconium group 's bowel showed serosal thickening , inflammation , focal fibrin , and collagen deposits . - pubmed
To investigate the role of passive cell death pathway in EAE , we used mice with transgenic expression of the long form of the bcl - x gene ( Bcl - x ( L ) ) targeted to the T - cell lineage . - pubmed
We found that mice transgenic for Bcl - x ( L ) have an earlier onset and a more chronic form of EAE induced by myelin oligodendrocyte glycoprotein ( MOG ) peptide 35 - 55 compared with wild - type littermate mice . - pubmed
This is the first report of an autoimmune disease model in Bcl - x ( L ) transgenic mice . - pubmed
Kawasaki disease on PDGF expression and VSMC proliferation . - pubmed
The effect of serum of patients with Kawasaki disease ( KD ) on expression of platelet - derived growth factor ( PDGF ) B chain protein in vascular endothelial cells ( VEC ) was studied by immunocytochemical method . - pubmed
The results showed that the serum of patients with KD induced the expression of PDGF - B chain protein significantly . - pubmed
These data suggest that the activation of PDGF - PDGF receptor may play a role in the pathogenesis of coronary complication of KD . - pubmed
In some patients , association of ataxia with specific serum antibodies ( antigliadin , antiglutamic acid decarboxylase ) suggests an immune pathogenesis . - pubmed
In vivo , all the isolated myotoxins induced release of creatine kinase due to necrosis of muscle fibers , accompanied by polymorphonuclear cell infiltration , and edema in the mouse paw . - pubmed
The myotoxic and cytotoxic activities of BthTX - I , a Lys49 PLA(2 ) homologue , after modification by BPB , RB , NBSF and NPSC , were reduced to 50 % , 20 % , 75 % , 65 % and 13 % , 0.5 % , 76 % , 58 % , respectively . - pubmed
BPB - treated BthTX - II , an Asp49 PLA(2 ) homologue , lost most of its catalytic , indirect hemolytic , anticoagulant , myotoxic and cytotoxic activities . - pubmed
The 80 patients , aged 1 mo , were divided into two groups based on the initial thyroid stimulating hormone ( TSH ) and free thyroxine ( FT4 ) values : a mild - moderately hypothyroid ( MHT ) group ( n = 64 , 31 M and 33F ) and a severely hypothyroid ( SHT ) group ( n = 16 , 3 M and 13F ) . - pubmed
Although serum creatinine kinase levels were significantly higher in the SHT group ( 230.3+/-102.3 U / L , p & lt ; 0.001 ) than in the MHT group ( 121.1+/-60.8 U / L ) , rhabdomyolysis was not considered to be responsible for the impaired renal function . - pubmed
The fractalkine levels in ejaculates from normal donors and infertile male patients with or without asthenozoospermia , were examined and correlated with sperm motility and morphology . - pubmed
Fractalkine titres in the seminal plasma of infertile men with asthenozoospermia ( 0.64 + /- 0.04 microg / ml ; n = 58 ) were lower than those in patients without asthenozoospermia ( 0.94 + /- 0.10 microg / ml ; n = 22 , P & lt ; 0.01 ) and fertile donors ( 1.04 + /- 0.07 microg / ml ; n = 10 , P & lt ; 0.001 ) . - pubmed
There was no significant difference between fractalkine levels in patients with and without leukospermia . - pubmed
Men and Blacks have a higher albumin excretion rate than do women and Whites and may thereby have an increased risk of microvascular and macrovascular disease . - pubmed
Vanadium increases GLUT4 in diabetic rat skeletal muscle . - pubmed
The response to BMOV by oral gavage was rapid and the animals were normoglycemic within 24 h of treatment and still demonstrated a significant effect even after 72 h. Using a specific antibody against GLUT4 we found an overall reduction in the GLUT4 in the total membrane fraction in skeletal muscle of diabetic animals . - pubmed
This is the first report that establishes a direct effect of vanadium on the regulation of GLUT4 expression in diabetic animals in vivo , and may at least partially explain the glucoregulatory effects of vanadium . - pubmed
Safety and efficacy of recombinant factor VIIa in patients with liver disease undergoing laparoscopic liver biopsy . - pubmed
METHODS : By establishing D - galactosamine - induced rat liver fibrosis model , we observed the effect of oxymatrine on serum and tissue biochemical indexes , content of liver hydroxyline , expression of TGF ? - pubmed
BIII-890 - CL is a non - orally active sodium channel blocker under development by Boehringer Ingelheim Corp for the potential treatment of thromboembolic stroke . - pubmed
[ Tropomyosin in myoma tissue ] . - pubmed
[ Effects of Oxymatrine on the expression of tissue inhibitor of metalloproteinase-1 and alpha - smooth muscle actin in the livers of rats with hepatic fibrosis ] . - pubmed
Cholestasis develops during inflammatory conditions characterized by the release of cytokines like interleukin-6 ( IL-6 ) , which is the major player in the hepatic acute - phase response . - pubmed
IL-6 is required for transporter down - regulation during aseptic inflammation . - pubmed
Furthermore , IL-6 also contributes to transporter regulation during LPS - induced cholestasis at more delayed time points . - pubmed
Functional COMT variant predicts response to high dose pyridoxine in Parkinson ' s disease . - pubmed
In this study , we examined the effect of the COMT ( L ) allele on the clinical response to pyridoxine in Parkinson ' s disease ( PD ) patients . - pubmed
Our observational study suggests that the status the functional COMT ( L ) variant may be potentially useful to select PD patients for high dose pyridoxine therapy . - pubmed
A second lactose tolerance test involving 10 g and 30 g of lactose was carried out in 10 subjects showing resistance to diarrhea , and serum glucose and insulin levels and the amount of hydrogen excreted in the breath were measured for comparison with those of glucose and lactitol . - pubmed
BACKGROUND : Although maternal anaemia often stems from malaria infection during pregnancy , its effects on foetal haemoglobin levels are not straightforward . - pubmed
Lower - than - expected cord haemoglobin values in malarious versus non - malarious regions were noted by one review , which hypothesized they resulted from foetal immune activation to maternal malaria . - pubmed
This study addressed this idea by examining cord haemoglobin levels in relation to maternal malaria , anaemia , and markers of foetal immune activation . - pubmed
METHODS : Cord haemoglobin levels were examined in 32 malaria - infected and 58 uninfected women in Blantyre , Malawi , in relation to maternal haemoglobin levels , malaria status , and markers of foetal haematological status , hypoxia , and inflammation , including TNF - alpha , TGF - beta , and ferritin . - pubmed
RESULTS : Although malaria was associated with a reduction in maternal haemoglobin ( 10.8 g / dL vs. 12.1 g / dL , p & lt ; 0.001 ) , no reduction in cord haemoglobin and no significant relationship between maternal and cord haemoglobin levels were found . - pubmed
Maternal malaria was associated with decreased TGF - beta and increased cord ferritin , the latter of which was positively correlated with parasitaemia ( r = 0.474 , p = 0.009 ) . - pubmed
Increased cord ferritin was associated with significantly decreased birth weight and gestational length , although maternal and cord haemoglobin levels and malaria status had no effect on birth outcome . - pubmed
CONCLUSION : In this population , cord haemoglobin levels were protected from the effect of maternal malaria . - pubmed
However , decreased TGF - beta and elevated ferritin levels in cord blood suggest foetal immune activation to maternal malaria , which may help explain poor birth outcomes . - pubmed
However , no studies have focused on determining the change in ( Na (+)/ K (+)) ATPase isoforms caused by chronic exposure to aluminum and its relation with aluminum toxicity . - pubmed
Macrophage inhibitory cytokine-1 H6D polymorphism , prostate cancer risk , and survival . - pubmed
Macrophage inhibitory cytokine-1 ( MIC-1 ) , a member of the transforming growth factor - beta superfamily , is important in regulating inflammation . - pubmed
A recent study ( JNCI 2004 , 96:1248 - 1254 ) found marginal evidence of an association between the presence of the mature MIC-1 protein nonsynonymous polymorphism H6D C - to - G ( rs1058587 ) with reduced prostate cancer risk [ odds ratio , 0.83 ; 95 % confidence interval ( 95 % CI ) , 0.69 - 0.99 ] . - pubmed
Our data suggest that the H6D variant in MIC-1 might play a role in prostate cancer , but it is difficult to explain how a variant can be associated with lower risk of developing prostate cancer but more aggressive growth if cancer develops . - pubmed
On the molecular basis linking Nerve Growth Factor ( NGF ) to Alzheimer ' s disease . - pubmed
This assertion has been at the basis of the hypothesis developed in the last 20 years , whereby NGF deprivation would be one of the factor involved in the etiology of sporadic forms of AD . - pubmed
In this review , we shall summarize data that lead to the production and characterization of a mouse model for AD ( AD11 anti - NGF mice ) , based on the expression of transgenic antibodies neutralizing NGF . - pubmed
The AD - like phenotype of AD11 mice will be discussed on the basis of recent studies that have posed NGF and its precursor pro - NGF back to the stage of AD - like neurodegeneration , showing the involvement of the precursor pro - NGF in one of the cascades leading to AD neurodegeneration . - pubmed
Some studies suggest that angiotensin II may influence some cellular pathways that contribute to the pathogenesis of IR and stimulate the release of proinflammatory cytokines . - pubmed
Fifty - two patients who had stages 3 and 4 CKD and no diabetes were administered an angiotensin receptor blocker ( ARB ) , olmesartan ( 40 mg ) , for 16 wk . - pubmed
Compared with control subjects , patients with CKD presented significantly higher BP and waist circumference , higher triglycerides and lower HDL levels , higher insulin levels , and higher mean HOMA index ( 6.0 + /- 2.7 versus 2.9 + /- 2.2 muU / ml x mmol / L ; P & lt ; 0.001 ) . - pubmed
In addition , patients with CKD had increased levels of high - sensitivity C - reactive protein , TNF - alpha , and IL-6 . - pubmed
In patients with CKD , leptin was positively correlated to abdominal obesity , insulin levels , and IL-6 , and adiponectin was inversely correlated to abdominal obesity and insulin levels . - pubmed
Acquired chromosomal rearrangements targeting selected transcription factors : contribution of molecular cytogenetic and expression analyses to the identification of clinically and biologically relevant subgroups in hematological malignancies . - pubmed
In leukemias characterized by 11q23 amplification , we described the amplicon and confirmed MLL , in addition to DDX6 , as a principal amplification target . - pubmed
Molecular characterization of a large series of unselected sporadic and recurrent 3q26 rearranged leukemias confirmed the decisive role of ectopic EVI1 expression in these malignancies . - pubmed
We contributed to an extensive analysis of the phenotypical and prognostic features of T - ALL characterized by HOX11L2 expression and identified HOX11L2 overexpression as one of the most frequent genetic defects in childhood T - ALL , associated with intermediate prognosis . - pubmed
Beta - interferon protects multiple sclerosis patients against enhanced susceptibility to infections caused by poor air quality . - pubmed
METHODS : The relapse rates of beta - interferon users and nonusers were compared to ambient air inhalable particle levels and viral infections in the population with logistic regression . - pubmed
PM(10 ) and virus infections had no significant effects in interferon users . - pubmed
CONCLUSION : In addition to being antiviral , interferon also protected multiple sclerosis patients against an enhanced susceptibility to infections caused by PM(10 ) . - pubmed
123I - ADAM SPECT imaging of serotonin transporter binding in patients with night eating syndrome : a preliminary report . - pubmed
Using knockout mice , we have also shown that TNF - alpha and both TNFR1 and TNFR2 are required for optimal control of B. - pubmed
The therapeutic benefits of interferon - beta are limited , as some patients with multiple sclerosis ( MS ) do not respond to therapy . - pubmed
Protein misfolding inside cells : the case of huntingtin and Huntington ' s disease . - pubmed
Milk fat globule epidermal growth factor - factor VIII is down - regulated in sepsis via the lipopolysaccharide - CD14 pathway . - pubmed
We have previously shown that the administration of MFG - E8 - rich exosomes from immature dendritic cells promotes the phagocytosis of apoptotic cells and improves survival in sepsis . - pubmed
Because endotoxin is elevated in polymicrobial sepsis , we hypothesized that down - regulation of MFG - E8 is mediated via the LPS - CD14 pathway , eventually leading to the accruement of apoptotic cells . - pubmed
Polymicrobial sepsis was induced by cecal ligation and puncture ( CLP ) in CD14 - deficient ( CD14(-/- ) ) , TLR4 - mutated and wild - type ( WT ) mice . - pubmed
Thus , MFG - E8 production is down - regulated in sepsis by LPS - CD14 dependent fashion , leading to a reduction of phagocytosis of apoptotic cells . - pubmed
Nutlin-3 is a MDM2 inhibitor under preclinical investigation as nongenotoxic activator of the p53 pathway for cancer therapy . - pubmed
Primary testicular presentation of ALK-1 - negative anaplastic large cell lymphoma in a pediatric patient . - pubmed
Regarding " C - reactive protein ( CRP ) elevation in patients with abdominal aortic aneurysm " . - pubmed
RECENT FINDINGS : Recent novel and promising findings include additional abnormalities in key pathways associated with thyroid tumorigenesis ( RET - Ras - BRAF - MEK ; RET - beta - cateinin ; TRK - PI3K - AKT ; and MDM - p53 - PTEN ) , single - nucleotide polymorphisms associated with thyroid cancer susceptibility , epigenetic silencing , alternative splicing , and gene expression abnormalities . - pubmed
Several studies indicate the involvement of protein kinases in the progression of various malignancies . - pubmed
CK2 kinase ( casein kinase-2 ) has been suggested to be a constituent of a neoplastic milleu , and its inhibition might represent a new approach to cancer therapy . - pubmed
We have examined the effects of 2 - dimethylamino-4,5,6,7 - tetrabromobenzimidazole ( DMAT ) , a potent CK2 inhibitor , on the H295R human adrenocortical cancer cell line . - pubmed
Nrf2 is a major transcriptional stimulator of cytoprotective genes and is critical for cancer prevention . - pubmed
Increased hepatic insulin action in diet - induced obese mice following inhibition of glucosylceramide synthase . - pubmed
We have previously shown that a specific inhibitor of glucosylceramide synthase , which inhibits the initial step in the synthesis of glycosphingolipids ( GSLs ) , improved glucose metabolism and decreased hepatic steatosis in both ob / ob and diet - induced obese ( DIO ) mice . - pubmed
CONCLUSIONS / SIGNIFICANCE : These results indicate that GSL inhibition in obese mice primarily results in an increase in insulin action in the liver , and suggests that GSLs may have an important role in hepatic insulin resistance in conditions of obesity . - pubmed
Immunohistochemical localization of glutathione s - transferase isoenzymes ( gsta , Gstp , Gstm4 , And Gstt1 ) and tumour marker p53 in matched tissue from normal larynx and laryngeal carcinoma : correlations with prognostic factors . - pubmed
OBJECTIVE : The immunohistochemical staining characteristics of glutathione S - transferase ( GST ) alpha ( GSTA ) , pi ( GSTP ) , mu ( GSTM4 ) , and theta ( GSTT1 ) and P53 were investigated in laryngeal squamous cell carcinoma ( LSCC ) cases and normal laryngeal tissue from 46 patients . - pubmed
The relationship between expression of the GST isoenzymes and P53 in normal and tumour tissue was analyzed using the Wilcoxon signed rank test . - pubmed
RESULTS : When the normal and tumour tissues of these cases were compared according to their staining intensity and percentage of positive staining , GSTA expression in normal cells was significantly higher than in tumour cells , and GSTP and P53 expression was higher in tumour cells ( p & lt ; .05 ) . - pubmed
GSTM and GSTT1 expression was higher in normal cells ; however , the statistical significance was low ( p & gt ; .05 ) . - pubmed
There was no correlation between P53 and GST expression in patients with LSCC . - pubmed
When the immunohistochemical results of GST isoenzymes and P53 were correlated with the clinical parameters , GSTA expression was increased in poorly differentiated laryngeal tumour , but GSTM4 and GSTT1 expression was decreased ( p & lt ; .05 ) . - pubmed
CONCLUSION : According to these results , GST - A , - P , and T1 and P53 were important in the diagnosis of LSCC . - pubmed
Erythropoietin - driven proliferation of cells with mutations in the tumor suppressor gene TSC2 . - pubmed
Lymphangioleiomyomatosis ( LAM ) is characterized by cystic lung destruction , resulting from proliferation of smooth - muscle - like cells , which have mutations in the tumor suppressor genes TSC1 or TSC2 . - pubmed
Because high red cell indexes could result from hypoxemia - induced erythropoietin ( EPO ) production , and EPO is a smooth muscle cell mitogen , we investigated effects of EPO in human cells with genetic loss of tuberin function , and we found that EPO increased proliferation of human TSC2-/- , but not of TSC2+/- , cells . - pubmed
Although the high red cell mass of LAM patients could be related to advanced disease , we propose that EPO , synthesized in response to episodic hypoxia , may increase disease progression by enhancing the proliferation of LAM cells . - pubmed
The influence of intracerebroventricullary - administered urocortin-2 , a selective corticotropin - releasing factor receptor 2 ( CRF ( 2 ) ) agonist , on rat anxiety - like behaviour , the expression of c - Fos and CRF , and plasma corticosterone levels was examined in the present study . - pubmed
These data suggest a role of urocortin-2 in the behavioural and immunocytochemical responses to stress , in which it strengthens the measures of anxiety - like responses . - pubmed
Indeed , PRL administration to ovariectomised rats significantly diminishes the deleterious effects of KA in the dorsal hippocampus and reduces the progression of KA - induced seizures . - pubmed
Despite the withdrawal of the first generation of cannabinoid type 1 receptor ( CB1 ) antagonists from the pharmaceutical market due to the occurrence of psychiatric adverse events , new evidence suggests that peripherally restricted CB1 antagonists might be efficacious for the treatment of obesity and its associated metabolic disorders . - pubmed
Ours results show the therapeutic importance of DA D ( 1 ) agonist in stress - induced dopaminergic - related neurological disorders . - pubmed
Neuroinflammatory Cytokines - The Common Thread in Alzheimer ' s Pathogenesis . - pubmed
This article discusses the potential role of the cytokine cycle and its corollary as drivers of the relentless progression of Alzheimer ' s neuropathologies , whether they are the result of gene mutations , gene polymorphisms , and/or environmental and comorbid conditions . - pubmed
Based on the discovery of cytokine overexpression as an accompaniment to the dementia - related glial activation , the cytokine hypothesis was proposed . - pubmed
This , together with demonstration of IL-1 induction of excessive production of the precursors of other features common in AD prompted a corollary to the cytokine hypothesis . - pubmed
The corollary states that regardless of the primary cause of the neuronal insult , the result will be chronic glial activation , which in turn will result in further neuronal injury , still more glial activation with excess cytokine expression and so on . - pubmed
Relation of systemic and urinary neutrophil gelatinase - associated lipocalin levels to different aspects of impaired renal function in patients with acute decompensated heart failure . - pubmed
Both urine and serum neutrophil gelatinase - associated lipocalin ( NGAL ) reflect active chronic kidney disease and predict acute kidney injury . - pubmed
We prospectively evaluated 93 patients admitted with acute decompensated heart failure and treated with intravenous furosemide and measured both systemic ( serum ) and urine NGAL levels and their corresponding markers of estimated glomerular filtration rate , natriuresis ( urine sodium ) , and diuretic response ( net output , urine sodium / furosemide ratio ) . - pubmed
Both markers predicted acute kidney injury ( urine NGAL , odds ratio 1.7 , p = 0.035 ; serum NGAL , odds ratio 1.9 , p = 0.009 ) . - pubmed
In conclusion , in patients with acute decompensated heart failure , urine NGAL levels reflect renal distal tubular injury with impaired natriuresis and diuresis , and systemic NGAL levels demonstrate a stronger association with glomerular filtration function . - pubmed
We further determined frontal cortex and hippocampal levels of oxidatively generated nuclear DNA damage , as measured by oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase sensitive sites detected by the comet assay , as well as the expression of genes involved in DNA repair ( Ogg1 and Nudt1 ) and inflammation ( Ccl2 and Tnf ) . - pubmed
Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson ' s disease . - pubmed
Polymorphisms in VMAT2 gene and in its regulatory regions might therefore serve as genetic risk factors for PD . - pubmed
In the present study , we have analyzed 8 single - nucleotide polymorphisms ( SNPs ) located within / around the VMAT2 gene for association with PD in an Italian cohort composed of 704 PD patients and 678 healthy controls . - pubmed
This study adds to the previous evidence suggesting that variability in VMAT2 promoter region may confer a reduced risk of developing PD , presumably via mechanisms of gene overexpression . - pubmed
Presence of the JAK2 V617F mutation in a patient with chronic neutrophilic leukemia and effective response to interferon alpha-2b . - pubmed
Chronic neutrophilic leukemia ( CNL ) is a rare type of leukemia characterized by a proliferation mainly of mature neutrophils , elevated neutrophil - alkaline phosphatase activity , and no presence of the Philadelphia chromosome . - pubmed
The JAK2 V617F mutation has been detected in patients with classical myeloproliferative disorders ( MPD ) including polycythemia vera and essential thrombocythemia and idiopathic myelofibrosis . - pubmed
In contrast , this same mutation has been detected in only 4 patients with CNL to date , suggesting that the JAK2 V617F mutation is a rare event in patients with atypical MPD . - pubmed
Here , we report a case of CNL with presence of the JAK2 V617F mutation . - pubmed
Finally , virulence studies in a murine sepsis model revealed attenuated virulence of the hpd1 mutant , which indicates generation of propionyl - CoA from host - provided nutrients during infection . - pubmed
Expression of human chorionic gonadotropin in testicular germ cell tumors . - pubmed
BACKGROUND : We have shown that most patients with seminomas have elevated serum concentrations of the free beta subunit of human chorionic gonadotropin ( hCGbeta ) and that in nonseminomatous testicular cancer , most of the hCG in the serum is hyperglycosylated ( hCG - h ) . - pubmed
However , the tissue expression of hCG - h or hCGbeta in germ cell tumors ( GCTs ) has not been reported . - pubmed
Our objective was to study the expression and diagnostic value of hCG - h and hCGbeta in testicular GCTs . - pubmed
METHODS : We studied the immunohistochemical expression of hCG , hCG - h , hCGbeta , and the free alpha subunit of hCG ( hCGalpha ) in GCTs from 154 patients . - pubmed
All forms of hCG , including hCG - h , were detected in embryonal carcinomas ( 22 % ) and mixed GCTs ( 48 % ) . - pubmed
Polyclonal hCG and monoclonal hCGbeta antibodies detected immunoreactivity in some seminomas ( 7 % ) . - pubmed
No form of hCG was found in spermatocytic seminomas , pure teratomas , or a yolk sac tumor . - pubmed
CONCLUSION : Trophoblastic tissue expresses hCG , hCG - h , and free subunits together whereas seminoma tissue occasionally expresses hCGbeta . - pubmed
Lithium induces microcysts and polyuria in adolescent rat kidney independent of cyclooxygenase-2 . - pubmed
It was hypothesized that renal cyclooxygenase-2 ( COX-2 ) activity promotes microcyst formation and NDI . - pubmed
Lithium treatment induced somatic growth retardation , renal microcysts and dilatations in cortical collecting duct ; it increased cortical cell proliferation and inactive pGSK-3beta abundance ; it lowered aquaporin-2 ( AQP2 ) protein abundance and induced polyuria with decreased ability to concentrate the urine ; and it increased COX-2 protein level in thick ascending limb . - pubmed
Concomitant treatment with lithium and a specific COX-2 inhibitor , parecoxib ( 5 mg / kg per day , P10 - P34 ) , did not prevent lithium - induced microcysts and polyuria , but improved urine concentrating ability transiently after a 1 - desamino-8 - D - arginine vasopressin challenge . - pubmed
In chronic lithium - treated adolescent rats , COX-2 is not colocalized with microcystic epithelium , mitotic activity , and inactive pGSK-3beta in collecting duct ; a blocker of COX-2 does not prevent cell proliferation , cyst formation , or GSK-3beta inactivation . - pubmed
It is concluded that COX-2 activity is not the primary cause for microcysts and polyuria in a NaCl - substituted rat model of lithium nephropathy . - pubmed
Discovery of ( S )- 1 -( 1 -( Imidazo [ 1,2 - a ] pyridin-6 - yl ) ethyl )- 6 -( 1 - methyl-1H - pyrazol-4 - yl )- 1H -[ 1,2,3 ] triazolo [ 4,5 - b ] pyrazine ( volitinib ) as a highly potent and selective mesenchymal - epithelial transition factor ( c - Met ) inhibitor in clinical development for treatment of cancer . - pubmed
HGF / c - Met signaling has been implicated in human cancers . - pubmed
Our transcriptome - wide identification of retained introns in SNW1- and PRPF8 - depleted cells may help to understand the aetiology of diseases associated with splicing defects , such as retinosa pigmentosum and cancer . - pubmed
Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs . - pubmed
Dysregulation of transactive response DNA - binding protein-43 ( TDP-43 ) is thought to be linked to the pathogenesis of amyotrophic lateral sclerosis ( ALS ) and frontotemporal lobar degeneration ( FTLD ) . - pubmed
TDP-43 normally localizes in the nucleus but its main localization shifts to the cytoplasm in most affected cells of ALS and FTLD patients . - pubmed
It is not yet known whether nuclear or cytoplasmic TDP-43 is responsible for TDP-43 - induced neurotoxicity . - pubmed
In this study , we show that nuclear TDP-43 causes TDP-43 neurotoxicity . - pubmed
Moreover , endogenous heterogeneous nuclear ribonucleoprotein - U ( hnRNP - U ) binds to TDP-43 and knocking - down of hnRNP - U induces neurotoxicity , whereas overexpression of hnRNP - U or hnRNP - A2 inhibits TDP-43 - induced neurotoxicity . - pubmed
Altogether , these results suggest that nuclear TDP-43 becomes neurotoxic by escaping from the inhibitory regulation by hnRNPs . - pubmed
Mitochondrial iron accumulation exacerbates hepatic toxicity caused by hepatitis C virus core protein . - pubmed
Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast , non - small cell lung , colorectal , and ovarian tumor tissues . - pubmed
To test this hypothesis and examine if human tumors utilize the erythropoietin receptor pathway , the response of tumor cells to human recombinant erythropoietin was investigated in disaggregated tumor cells obtained from 186 patients with colorectal , breast , lung , ovarian , head and neck , and other tumors . - pubmed
A cocktail of well characterized tumor growth factors ( EGF , HGF , and IGF-1 ) were analyzed in parallel as a positive control to determine whether freshly - isolated tumor cells were able to respond to growth factor activation ex vivo . - pubmed
Exposing tumor cells to the growth factor cocktail resulted in stimulation of survival and proliferation pathways as measured by an increase in phosphorylation of the downstream signaling proteins AKT and ERK . - pubmed
In contrast , no activation by human recombinant erythropoietin was observed in isolated tumor cells . - pubmed
Though tumor samples exhibited a broad range of cell - surface expression of EGFR , c - Met , and IGF-1R , no cell - surface erythropoietin receptor was detected in tumor cells from the 186 tumors examined ( by flow cytometry or Western blot ) . - pubmed
Circulating miR-150 has been recently proposed as a better biomarker of HF than traditional clinical markers such as brain natriuretic peptide . - pubmed
The cardioprotective roles of miR-150 during ischaemic injury were in part attributed to direct repression of the pro - apoptotic genes egr2 ( zinc - binding transcription factor induced by ischaemia ) and p2x7r ( pro - inflammatory ATP receptor ) in cardiomyocytes . - pubmed
Although expression and function of HSPA2 is mainly associated with spermatogenesis , recent studies demonstrated that in humans , the gene is active in various cancers , as well as in normal tissues , albeit in a cell type - specific manner . - pubmed
This study was aimed at determining whether HIF-1 and its binding site , the hypoxia - response element ( HRE ) located in the HSPA2 promoter , are involved in HSPA2 regulation . - pubmed
Using an in vitro gene reporter assay , we demonstrated that in keratinocytes HSPA2 promoter activity is reduced under conditions that facilitate stabilization of HIF-1alpha , whereas HIF-1 inhibitors abrogated the suppressive effect of hypoxia on promoter activity . - pubmed
In keratinocytes , hypoxia or overexpression of a stable form of HIF-1alpha attenuated the expression of endogenous HSPA2 , whereas targeted repression of HIF-1alpha by RNAi increased transcription of HSPA2 under hypoxia . - pubmed
Conversely , in HeLa cells , HSPA2 expression increased under conditions that stimulated HIF-1alpha activity , whereas inhibition of HIF-1alpha abrogated hypoxia - induced up - regulation of HSPA2 expression . - pubmed
Additionally , we also showed that HSPA2 expression can be stimulated during hypoxia / reoxygenation stress . - pubmed
Finally , FA could overload energy homeostasis via increased hypothalamic ceramide synthesis which could , in turn , contribute to the pathogenesis of diabetes of obesity and/or type 2 in predisposed individuals by disrupting the endocrine signaling pathways of insulin and/or leptin . - pubmed
RESULTS : Compared with healthy volunteers , patients with DLBCL had significantly higher leukocyte and monocyte counts ( P & lt ; .001 ) ; higher percentages of neutrophils ( P & lt ; .001 ) , " natural " regulatory T cells ( Tregs ; CD3+Foxp3 + , P & lt ; .001 ) , and immature DCs ( CD83 - CD1a+ , P = .005 ) ; and lower percentages of lymphocytes ( P & lt ; .001 ) and helper T cells ( P = .038 ) . - pubmed
Interferon - inducible GTPase : a novel viral response protein involved in rabies virus infection . - pubmed
Several studies have shown that interferon - inducible GTPases are involved in many biological processes , such as viral infection , endoplasmic reticulum stress response , and autophagy . - pubmed
These findings indicate that interferon - inducible GTPases are likely to be a potential target involved in rabies pathogenesis or the antiviral process . - pubmed
The degradation and accumulation of eosinophils , release of cytokines , and mucus secretion have important roles in the pathogenesis of ECRS . - pubmed
This review describes the clinical course , diagnosis , and treatment of ECRS as well as its pathophysiology and the role of eosinophils , mucus , cytokines , and other mediators in the pathogenesis of ECRS . - pubmed
Mycoplasma bovis MBOV _ RS02825 Encodes a Secretory Nuclease Associated with Cytotoxicity . - pubmed
This study aimed to determine the activity of one Mycoplasma bovis nuclease encoded by MBOV_RS02825 and its association with cytotoxicity . - pubmed
MAP kinase ( MPK ) cascades in Arabidopsis thaliana and other vascular plants are activated by developmental cues , abiotic stress , and pathogen infection . - pubmed
Serum Calprotectin Expression as a Diagnostic Marker for Sepsis in Postoperative Intensive Care Unit Patients . - pubmed
The research was performed to explore the diagnosis value of dynamic serum calprotectin ( SC ) expression for sepsis in postoperative intensive care unit patients . - pubmed
The effect of TMEFF2 methylation on the tumor stage and survival outcome of clear cell renal cell carcinoma . - pubmed
AIM : This study aimed to investigate the methylation status of EGF - like and two follistatin - like domains 2 ( TMEFF2 ) promoter and its correlation with tumor stage and survival outcome in renal cell carcinoma ( RCC ) . - pubmed
MATERIALS AND METHODS : Paraffin - embedded specimens from 42 RCC patients were analyzed for TMEFF2 methylation by methylation - specific polymerase chain reaction . - pubmed
CONCLUSION : These findings showed that TMEFF2 methylation is not rare in RCC , and methylation may play an important role in the tumorigenesis of ccRCC . - pubmed
Randomized Trial of the Effect of Magnesium Sulfate Continuous Infusion on IL-6 and CRP Serum Levels Following Abdominal Aortic Aneurysm Surgery . - pubmed
In this study , we aimed to investigate the impact of Mg loading following AAA surgery on two inflammation markers , IL-6 and CRP , as well as patient 's outcome . - pubmed
The MOF - UCNP core - satellite superstructures also induce strong cell cytotoxicity against cancer cells , which are further enhanced by attaching epidermal growth factor receptor targeting affibodies to the PDT clusters , highlighting their promise as theranostic photodynamic agents . - pubmed
Long non - coding RNA NEAT1 overexpression is associated with unfavorable prognosis in patients with hepatocellular carcinoma after hepatectomy : A Chinese population - based study . - pubmed
RESULTS : For the entire cohort of 86 patients , we showed that the expression level of NEAT1 was significantly higher in HCC tissues compared with non - tumorous tissues and NEAT1 was increased obviously in the HCC cell lines including SMMC-7721 , Huh-7 and Hep3B ( P & lt ; 0.001 ) . - pubmed
CONCLUSIONS : In this study , we found NEAT1 expressed significantly higher in HCC tissues compared with non - tumorous tissues . - pubmed
INTRODUCTION : To compare the percentage of arterial oxygen saturation ( SpO2 ) in healthy teeth with confirmed pulp vitality between individuals with sickle cell anemia ( HbSS ) and normal hemoglobin A ( HbAA ) . - pubmed
Furthermore expression of the enzyme responsible for PGD2 synthesis ( hematopoietic prostaglandin D synthase , HPGDS ) was increased in obese adipose tissues and remained high after weight loss . - pubmed
Increased HPGDS expression was also observed in human adipose tissues obtained from obese compared with lean individuals . - pubmed
Influence of LGALS3 gene polymorphisms on susceptibility and prognosis of dilated cardiomyopathy in a Northern Han Chinese population . - pubmed
BACKGROUND : Galectin-3 plays an important role in modulating cardiac inflammation and fibrosis . - pubmed
Therefore , LGALS3 gene , encoding galectin-3 protein , is a promising candidate for the genetic study of dilated cardiomyopathy ( DCM ) . - pubmed
To date , there has been no research evaluating the association between LGALS3 gene polymorphisms and the susceptibility and prognosis of DCM . - pubmed
METHODS AND RESULTS : Genotyping of 4 single nucleotide polymorphisms ( SNPs ) in the LGALS3 gene , which were reported to be functional in the literature , was performed in 279 unrelated clinically diagnosed DCM patients and 363 apparently healthy controls from Northern Han Chinese population using iPLEX SNP Genotyping analysis on a Sequenom MassARRAY System . - pubmed
The G variant of rs1009977 was related with lower serum galectin-3 level in DCM patients under three genetic models ( additive model , P=0.020 , dominant model , P=0.020 , recessive model , P=0.037 ) . - pubmed
The A variant of both rs2274273 and rs4644 was associated with lower level of galectin-3 in DCM patients under additive model ( P=0.032 for both ) and dominant model ( P=0.012 for both ) . - pubmed
In Conclusion , LGALS3 gene polymorphisms might be associated with the susceptibility of DCM in a Northern Han Chinese population . - pubmed
Caveolin-1 ( CAV1 ) is a scaffolding protein that modulates signaling pathways leading to remodeling of the actin cytoskeleton and enhanced migration of cancer cells . - pubmed
Correction to : Secondary antibody deficiency : a complication of anti - CD20 therapy for neuroinflammation . - pubmed
PHOSPHO1 is essential for normal bone fracture healing : An Animal Study . - pubmed
Methods : Tibial fractures were created and then stabilized in control wild - type ( WT ) and Phospho1-/- mice ( n = 16 for each group ; mixed gender , each group carrying equal number of male and female mice ) at eight weeks of age . - pubmed
An increase in trabecular number and a decrease in trabecular thickness and separation were observed in Phospho1-/- callus in comparison with the WT callus . - pubmed
Conclusion : Our work suggests that PHOSPHO1 plays an integral role during bone fracture repair and may be a therapeutic target to improve the fracture healing process . - pubmed
PHOSPHO1 is essential for normal bone fracture healing : An Animal Study . - pubmed
Improvement and extension of anti - EGFR targeting in breast cancer therapy by integration with the Avidin - Nucleic - Acid - Nano - Assemblies . - pubmed
Even if further studies are needed , we propose that NP tethering could expand application of the anti - EGFR antibody to a wider number of cancer patients including the KRAS - mutated ones , currently suffering from poor prognosis . - pubmed
Thus , resveratrol as a hypoxia - inducible factor-1 - alpha inhibitor increased the radiosensitization of breast cancer spheroid cells . - pubmed
Determining the expression levels of CD45 and Foxp3 using immunohistochemistry facilitated the correct classification of HCC patients and the prediction of their prognosis . - pubmed
In 2018 , The Food and Drug Administration ( FDA ) of the US approved several novel agents for AML treatment as follows : ivosidenib , an inhibitor of isocitrate dehydrogenase-1 ; venetoclax , a potent inhibitor of bcl2 ; and glasdegib , an inhibitor of hedgehog signaling pathway . - pubmed
Duplication of MECP2 - containing genomic segments causes MECP2 duplication syndrome , a severe neurodevelopmental disorder characterized by intellectual disability , motor dysfunction , heightened anxiety , epilepsy , autistic phenotypes , and early death . - pubmed
Here , we found that MECP2 - TG mice showed a significant social recognition deficit , and were prone to display aversive - like behaviors , including heightened anxiety - like behaviors and a fear generalization phenotype . - pubmed
We used the CRISPR - Cas9 method to restore normal MeCP2 levels in the medial prefrontal cortex ( mPFC ) and bed nuclei of the stria terminalis ( BST ) of adult MECP2 - TG mice , and found that normalization of MeCP2 levels in the mPFC but not in the BST reversed the social recognition deficit . - pubmed
Thrombin generation assay modifications needed for its application to monitoring of replacement therapy for haemophilia . - pubmed
Major depressive disorder ( MDD ) is associated with alterations of GABAergic interneurons , notably somatostatin ( Sst ) as well as parvalbumin ( Pvalb ) , in cortical brain areas . - pubmed
Assessment of Plasma Amyloid - beta42 / 40 and Cognitive Decline Among Community - Dwelling Older Adults . - pubmed
Importance : Plasma measurement of amyloid - beta ( Abeta ) peptides has been associated with cognitive function , but evidence of its ability to identify cognitive decline is still scarce . - pubmed
After adjusting for age , sex , education , body mass index , Geriatric Depression Scale score , apolipoprotein E epsilon4 genotype , and MAPT intervention groups , low plasma Abeta42 / 40 was associated with more pronounced decline in composite cognitive score ( adjusted between - group mean difference : -0.20 , 95 % CI , -0.34 to -0.07 ; P = .004 ) and decline in MMSE score ( adjusted between - group mean difference : -0.59 ; 95 % CI , -1.07 to -0.11 ; P = .02 ) during the follow - up period compared with the group with an Abeta42 / 40 ratio greater than 0.107 . - pubmed
Findings suggest that plasma Abeta42 / 40 may be used to identify people at risk of cognitive decline , being an alternative to more complex and expensive measures , such as positron emission tomography imaging or cerebrospinal fluid measurement . - pubmed
Secretin ( 1 CU / Kg ) plus Caerulein ( 100 ng / Kg ) or Cholecystokinin ( 1 or 2 IvyU / Kg ) were given by rapid intravenous injection ( Schedule 1 ) or by continuous infusion ( Schedule 2 ) to 63 control subjects ( C ) and 69 patients affected by chronic pancreatitis ( CP ) . - pubmed
HL - A antigens , autoantibody production , and associated diseases in thymoma patients , with and without myasthenia gravis . - pubmed
Histocompatibility ( HL - A ) antigens were tested in 24 thymoma ( + ) MG ( + ) , 23 thymoma ( + ) MG ( - ) , and 43 thymoma ( - ) MG ( + ) patients and 533 controls from the Dutch population . - pubmed
The frequencies of HL - A8 were significantly decreased in both thymoma groups that had a relatively high incidence of associated immunological disorders ( Table 5 ) . - pubmed
Oxidized alpha 1 - proteinase inhibitor may thus be considered as a physiological inhibitor of human pancreatic elastase which may prevent degradation of blood vessel elastin during acute hemorrhagic pancreatis . - pubmed
Previous studies have demonstrated the importance of antibodies in mediating immunity to malaria , but the relative contribution of the different immunoglobulin isotypes has not been assessed . - pubmed
Only mice receiving IgG2a antibodies experienced an altered course of infection . - pubmed
HLA antigens were studied in 121 patients with dissemination sclerosis and 50 patients with retrobulbar neuritis . - pubmed
Effects of neurotropin in patients with hereditary spino - cerebellar degeneration . - pubmed
Rather than promoting tumorigenesis in vasopressinergic cells of the hypothalamus , expression and activity of the hybrid oncogene , and consequent tumor formation , were confined to insulin - producing beta cells of the endocrine pancreas and to cells in the anterior pituitary . - pubmed
These actions can be of importance in normal physiological situations as well as in abnormal conditions where IGF - I is decreased , such as hypopituitarism and malnutrition . - pubmed
The rare , but not zero , associations of beta A with the 13 kb linkage and of beta s genes with the 7.6 kb fragment would lessen the accuracy in the prenatal diagnosis of sickle cell anaemia in this population through the use of the HpaI polymorphism . - pubmed
The 48 - 1 antibody reacted with liver biopsy specimens from 12 chimpanzees obtained during the acute or chronic phase of hepatitis caused by five different NANB strains , but not with biopsy specimens from chimpanzees with hepatitis A or B or from normal chimpanzees . - pubmed
The risk of respiratory disease did not show significant correlation with- and globulin levels and with serum protein and IgG1 levels at the time of purchase . - pubmed
Hemoglobin Indianapolis was first described by Adams et al ( 1,2 ) as a very unstable variant with a phenotype similar to severe beta - thalassemia . - pubmed
Growth hormone in Turner syndrome . - pubmed
Steroid receptors in tumors of nerve sheath origin . - pubmed
To investigate the relationship between elevated adipose tissue lipoprotein lipase ( LPL ) activity and triglyceride uptake in Zucker obese rats , fed and 12 hour fasted female obese and lean Zucker rats were given intrajugular infusion of radio - labelled triglyceride and label clearance and uptake were examined over 35 minutes . - pubmed
Regardless of feeding condition , obese rats exhibited elevations in adipose tissue LPL , which was significantly correlated with label uptake in adipose tissue . - pubmed
These results show that , in Zucker obese rats , elevated adipose tissue LPL is associated with increased adipose tissue triglyceride uptake . - pubmed
A preferential " shunting of calories " into adipose tissue , which is presumably mediated by LPL , could underlie the intractability of the Zucker obesity syndrome as well as the altered feeding behavior of Zucker obese rats . - pubmed
luteal insufficiency " is characterized by a very low concentration of estradiol receptor . - pubmed
The dextran - coated charcoal assay method of McGuire and DeLaGarza is a well - known method for quantitation of oestrogen receptors in breast tumour tissues . - pubmed
In this report we compare the results obtained using both methods to quantitate oestrogen receptors and determine the affinity for steroid binding in seven human breast tumours and the uteri of rat and calf . - pubmed
To assess the efficacy and time - dependent effects of once - daily moexipril , a nonsulfhydryl ester prodrug of the angiotensin - converting enzyme ( ACE ) inhibitor , moexiprilat , we conducted a multicenter , double - blind , placebo - controlled trial in 51 hypertensive patients using both clinic and ambulatory blood pressure ( BP ) recordings . - pubmed
Previous studies demonstrated that stimulation of type B gamma - aminobutyric acid ( GABAB ) receptors but not type A ( GABAA ) receptors in the nucleus tractus solitarius of spontaneously hypertensive rats elicited a larger increase in arterial pressure compared with control rats of the Wistar - Kyoto strain . - pubmed
The present studies extended that observation by examining the cardiovascular response to injection into the nucleus tractus solitarius of a selective GABAB receptor antagonist , CGP 35348 , in these strains as well as examining the cardiovascular responses to stimulation or blockade of GABAB receptors in the nucleus tractus solitarius in another model of hypertension , the rat treated with deoxycorticosterone acetate and salt . - pubmed
Similarly , in both models of hypertension , the depressor response elicited by blockade of GABAB receptors in the nucleus tractus solitarius by injection of CGP 35348 was approximately 75 % greater compared with control rats ( P & lt ; .05 in each model ) . - pubmed
Failure of a protective major histocompatibility complex class II molecule to delete autoreactive T cells in autoimmune diabetes . - pubmed
We show that neither thymic deletion nor anergy of autoreactive T cells occurs in NOD mice transgenic for I - Ak. - pubmed
Supravalvular aortic stenosis associated with a deletion disrupting the elastin gene . - pubmed
In recent studies we presented evidence suggesting that a translocation disrupting the elastin gene caused SVAS in one family while deletions involving the entire elastin locus caused WS . - pubmed
In this study , pulsed - field , PCR , and Southern analyses showed that a 100 - kb deletion of the 3 ' end of the elastin gene cosegregated with the disease in another SVAS family . - pubmed
DNA sequence analysis localized the breakpoint between elastin exons 27 and 28 , the same region disrupted by the SVAS - associated translocation . - pubmed
These data indicate that mutations in the elastin gene cause SVAS and suggest that elastin exons 28 - 36 may encode critical domains for vascular development . - pubmed
Recently it has been demonstrated that the cytokines granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , interleukin-3 ( IL-3 ) , and interleukin-5 ( IL-5 ) are present in the circulation of individuals with allergic asthma . - pubmed
Here the effect of nedocromil sodium on the chemotactic response of eosinophils from allergic asthmatic individuals and from normal donors preincubated with GM - CSF or IL-3 toward FMLP , NAF / IL-8 was evaluated . - pubmed
Dimeric inhibin A as a marker for Down ' s syndrome in early pregnancy . - pubmed
BACKGROUND : In screening for Down ' s syndrome in the second trimester of pregnancy , the concentrations of alpha - fetoprotein , the beta subunit of human chorionic gonadotropin , and intact human chorionic gonadotropin in material serum are widely used markers . - pubmed
Individual serum concentrations of each marker were converted to multiples of the median value at the appropriate length of gestation in the women with normal pregnancies , and rates of detection of Down ' s syndrome by screening for inhibin A in various combinations with the other markers were estimated by multivariate analysis . - pubmed
RESULTS : In the women with fetuses affected by Down ' s syndrome , the serum inhibin A concentrations were 2.06 times the median value in the women with normal pregnancies ( P & lt ; 0.001 ) . - pubmed
The serum concentrations of inhibin A in the women with fetuses affected by Down ' s syndrome did not appear to be significantly elevated above normal until the end of the first trimester and were not significantly different from normal in the women with fetuses affected by trisomy 18 ( P = 0.17 ) . - pubmed
The rate of detection of Down ' s syndrome was 53 percent and the false positive rate was 5 percent when alpha - fetoprotein , the beta subunit of human chorionic gonadotropin , the maternal age were used together as predictors . - pubmed
CONCLUSIONS : In the second trimester of pregnancy , measuring inhibin A in maternal serum , in combination with measurements of alpha - fetoprotein and beta subunit of human chorionic gonadotropin , significantly improved the rate of detection of Down ' s syndrome . - pubmed
The spectrum of anemias treated with recombinant human erythropoietin is rapidly broadening . - pubmed
Receptor for interleukin ( IL ) 13 does not interact with IL4 but receptor for IL4 interacts with IL13 on human glioma cells . - pubmed
Recently , we have demonstrated that human ( h ) glioma cell lines express large number of receptors ( R ) for interleukin 13 ( IL13 ) ( Debinski , W. , Obiri , N. I. , Powers , S. K. , Pastan , I. , and Puri , R. K. ( 1995 ) Clin . - pubmed
Glucocorticoid regulation of hepatic TNF production following cecal ligation and puncture sepsis . - pubmed
Many of the harmful effects evident during sepsis are ascribed to excessive endogenous TNF production . - pubmed
Because the liver is an important source of circulating TNF during endotoxicosis , and because glucocorticoids are believed to have a regulatory role in suppressing endogenous TNF production , we evaluated the effect of adrenalectomy on the hepatic production of TNF in an isolated perfused liver model after cecal ligation and puncture ( CLP ) sepsis . - pubmed
Thus , adrenalectomy increased circulating TNF and hepatic TNF production as well as mortality in CLP sepsis . - pubmed
These findings suggest an important role for endogenous glucocorticoids in modulating hepatic TNF production during CLP - induced sepsis . - pubmed
[ Intraoperative serum parathyroid hormone measurement in the surgical treatment of hyperparathyroidism ] . - pubmed
BACKGROUND : PTH(1 - 84 ) short half life permits us to monitor parathyroidectomy efficacy , confirming complete resection after unilateral surgical approach in some cases of primary hyperparathyroidism . - pubmed
PATIENTS AND METHODS : In 18 consecutive patients operated on for primary or secondary hyperparathyroidism , serum PTH(1 - 84 ) concentrations were assessed at different times before , during and after partial ( in 11 patients with multiglandular illness ) and total resections . - pubmed
Such MSI has been found to be associated with hereditary nonpolyposis colorectal cancer ( HNPCC ) that involves mutation of the human mismatch repair genes hMSH2 and hMLH1 as well as many sporadic cancers of most tissue types . - pubmed
Fourteen of the 15 high MSI tumors had lost either hMSH2 ( n = 8) or hMLH1 ( n = 6 ) protein expression . - pubmed
In contrast , all of the low MSI tumors and the MSI - negative tumors displayed normal expression of hMSH2 and hMLH1 . - pubmed
The authors report on the interferons and evolving therapies for chronic viral hepatitis and conclude with a discussion of liver transplantation . - pubmed
There were no significant differences in cytokine production among the various groups , except for a decrease in tumor necrosis factor production in malnourished cancer patients , which was restored by omega-3 fatty acids . - pubmed
Examining the clinical findings in the mono group ( those with monoclonal IgM alone ) and the poly group ( those with polyclonal IgM alone or polyclonal and monoclonal IgM ) we found clearly significant differences : more severe liver involvement in the poly group , and higher cryocrit and creatinine values , lower C4 level and more severe purpura in the mono group . - pubmed
PML / RARalpha is the leukemogenetic protein of acute promyelocytic leukemia ( APL ) . - pubmed
We studied the antitumor activity and toxicity of ZD1694 ( tomudex ) , a specific inhibitor of thymidylate synthase ( TS ) , in nude mice bearing human head and neck squamous cell carcinoma A253 and FaDu xenografts . - pubmed
High plasma thymidine in mouse relative to human ( approximately 1.3 microM and & lt;0.1 microM , respectively ) may complicate the study of antitumor activity and toxicity of TS inhibitors with human tumor xenografts grown in the mouse . - pubmed
However , rodent models , particularly human tumor xenografts , are still useful models for evaluation of antitumor activity and schedule selection for TS inhibitors . - pubmed
In the presence of the beta ( 2 )- adrenoceptor antagonist , ICI 118551 , a hindquarters vasoconstrictor response to human leptin was not seen , and there was a tachycardia , as there was to murine leptin . - pubmed
Human kallikrein 6 as a biomarker of alzheimer ' s disease . - pubmed
A few biomarkers , including tau protein and amyloid beta-42 , are now used as aids for diagnosis and monitoring of AD . - pubmed
Our aim was to examine the possible use of cerebrospinal fluid , blood and tissue , and human kallikrein 6 ( hK6 ) concentration as a marker of AD . - pubmed
We measured hK6 in tissue extracts from AD brain or normal individuals , in cerebrospinal fluids of AD patients or normals and in whole blood of AD patients and normals and compared the findings . - pubmed
RESULTS : We found that hK6 concentration is tissue extracts from AD brain were approximately twofold lower than extracts from normal controls . - pubmed
We have also found that the whole blood hK6 concentration in AD patients is about ten times higher than hK6 concentration in normal controls ( p = 0.002 ) . - pubmed
CONCLUSIONS : This is the first report describing significant elevations of cerebrospinal fluid and plasma and whole blood hK6 concentration in AD patients , in comparison to controls . - pubmed
These data suggest that hK6 may constitute a new biomarker for diagnosis and monitoring of AD . - pubmed
The reverse transcriptase enzyme telomerase is responsible for maintaining telomeric DNA length in over 85 % of cancer cells by catalyzing the synthesis of further telomeric repeats . - pubmed
The myocardial adaptation to atrial fibrillation , the so - called " atrial remodeling " , includes shortening of the atrial refractory period , slowing of atrial conduction , shortening of the atrial action potential , a progressive reduction of L - type calcium channel expression and microfibrosis of the myocardial tissue . - pubmed
Exclusion of linkage of nine neuronal nicotinic acetylcholine receptor subunit genes expressed in brain in autosomal dominant nocturnal frontal lobe epilepsy in four unrelated families . - pubmed
Members of the ligand - gated neuronal nicotinic acetylcholine receptor ( nAChR ) gene family ( CHRNA4 and CHRNB2 , coding for the alpha4 and beta2 subunits , respectively ) are involved in autosomal dominant nocturnal frontal lobe epilepsy ( ADNFLE ) . - pubmed
However , ADNFLE is genetically heterogeneous and mutations in CHRNA4 and CHRNB2 account for only a minority of ADNFLE cases . - pubmed
Additional nAChR subunits expressed in the brain are candidates for this epilepsy . - pubmed
The involvement of all genes coding for brain - expressed nAChR subunits , with known chromosome localization ( CHRNB2 , 1q21 ; CHRNA2 , 8p21 ; CHRNA6 , CHRNB3 , 8p11.2 ; CHRNA7 , 15q14 ; CHRNA5 / A3 / B4 , 15q24 and CHRNA4 , 20q13.2 ) was investigated in four unrelated ADNFLE Italian families for at least three generations . - pubmed
These findings support the hypothesis that genes different from those coding for alpha2 - 7 and beta2 - 4 neuronal nAChR subunits could be responsible for ADNFLE . - pubmed
The frequency of allele TNF2 in tuberculosis patients was significantly higher than in controls ( chi 2 = 11.69 , p = 0.001 ) , suggesting an association of this allele with higher risk of pulmonary tuberculosis or a disturbed immune response . - pubmed
Urinary sediment , quantitative proteinuria , creatinine clearance , antinuclear antibodies ( ANA ) , complement , circulating immune complexes ( CIC ) and renal biopsies were evaluated in all of the patients . - pubmed
Furthermore , abnormal levels of CIC , CH50 and C3 associated with WHO class II suggest a moderate but ongoing activation of immune - mediated renal injury mechanisms . - pubmed
Recent anti - cytokine therapy for inflammatory diseases including rheumatoid arthritis aimed to inhibit the binding of cytokines to targeted cells such as fibroblasts and condrocytes . - pubmed
This paper will review the utilization of soluble receptors specific to inflammatory cytokines which potentially stimulate fibroblasts to regulate biological events involved in the pathogenesis of periodontal diseases . - pubmed
SMAGP , a new small trans - membrane glycoprotein altered in cancer . - pubmed
Immunohistochemical data obtained using human breast , colon and lung cancer samples sustain this hypothesis since they showed that , in both primary tumours and metastases , reduced expression and/or cytoplasmic redistribution of SMAGP is superimposable with low histological tumour differentiation features , namely a lack of epithelial cell polarity and disorganized tissue phenotype . - pubmed
Nonetheless , both Src and PP2A enzymes are critical targets of E4orf4 that likely cooperate to trigger E4orf4 - induced tumor cell killing and whose relative contributions may vary in function of the cellular background . - pubmed
OBJECTIVES : Adiponectin has been implicated in the pathophysiology of metabolic syndrome and coronary artery disease in humans . - pubmed
Clinical effects of Abeta immunization ( AN1792 ) in patients with AD in an interrupted trial . - pubmed
CONCLUSION : Although interrupted , this trial provides an indication that Abeta immunotherapy may be useful in Alzheimer disease . - pubmed
Value of C reactive protein in the assessment of erosive osteoarthritis of the hand . - pubmed
OBJECTIVE : To investigate the value of serum C reactive protein ( CRP ) as a marker of erosive osteoarthritis ( EOA ) of the hand . - pubmed
In all patients , CRP correlated with RS ( r(s ) = 0.43 , p<0.001 ) , and mainly with JC at clinical observation ( r(s ) = 0.72 , p<0.001 ) and at bone scintigraphy ( r(s ) = 0.47 , p<0.001 ) . - pubmed
The correlation of CRP with RS and JC was confirmed at clinical observation and at bone scintigraphy in the EOA subgroup , but only with JC at clinical observation in the non - EOA subgroup . - pubmed
Severe chronic experimental autoimmune uveitis ( EAU ) of the C57BL/6 mouse induced by adoptive transfer of IRBP1 - 20 - specific T cells . - pubmed
B10RIII and B10A mouse are highly susceptible to IRBP - induced uveitis , whereas B6 mouse is less susceptible . - pubmed
Compared with the RDR , the sensitivity and specificity to detect vitamin A deficiency for each test was , respectively : serum retinol , 90 % and 78 % ; retinol - binding protein ( RBP ) , 40 % and 91 % ; retinol / RBP molar ratio , 60 % and 74 % ; conjunctival impression cytology , 44 % and 48 % ; slit - lamp examination , 20 % and 66 % ; tear film break - up time , 40 % and 69 % ; and Schirmer 's test , 20 % and 78 % . - pubmed
Because TLR7 agonists can impede HCV infection both via type I IFN and independently of IFN , they may be considered as an alternative treatment of chronic HCV infection , especially in IFN - alpha - resistant patients . - pubmed
The emerging use of TNF - alpha inhibitors in orbital inflammatory disease . - pubmed
Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma : implications for hepatic anti - tumour immunity . - pubmed
This study examines the cytokine milieu of normal and tumour - bearing liver , quantifying pro-/anti - inflammatory cytokines using modified ELISAs and real - time quantitative PCR . - pubmed
Inflammatory IFN - gamma was increased in tumour - bearing liver ( p<0.0001 ) . - pubmed
However , a much greater increase in anti - inflammatory IL-10 , produced by non - parenchymal cells ( p<0.0005 ) , resulted in a reduced IFN - gamma : IL-10 ratio in tumour - bearing liver ( p<0.02 ) . - pubmed
The IFN - gamma inducing cytokine , IL-18 was increased in tumour - bearing liver ( p<0.02 ) , while pro - inflammatory TNF - alpha was suppressed ( p<0.05 ) . - pubmed
These results suggest that , whilst there is a significant inflammatory immune response in tumour - bearing liver , evidenced by increased levels of IFN - gamma , disproportionate increase in IL-10 may be a key factor in facilitating tumour progression . - pubmed
GM - CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis . - pubmed
BACKGROUND : Increased mortality from infection in patients with pulmonary alveolar proteinosis occurs in association with high levels of autoantibodies against granulocyte - macrophage colony - stimulating factor ( GM - CSF ) . - pubmed
We tested the hypothesis that neutrophil functions are impaired in patients with pulmonary alveolar proteinosis and that GM - CSF autoantibodies cause the dysfunction . - pubmed
RESULTS : Neutrophils from subjects with pulmonary alveolar proteinosis had normal ultrastructure and differentiation markers but impaired basal functions and antimicrobial functions after GM - CSF priming . - pubmed
The neutrophil dysfunction characteristic of pulmonary alveolar proteinosis was reproduced in a dose - dependent fashion in blood specimens from healthy control subjects after incubation with affinity - purified GM - CSF autoantibodies isolated from patients with pulmonary alveolar proteinosis . - pubmed
The injection of mouse GM - CSF antibodies into wild - type mice also caused neutrophil dysfunction . - pubmed
CONCLUSIONS : The antimicrobial functions of neutrophils are impaired in patients with pulmonary alveolar proteinosis , owing to the presence of GM - CSF autoantibodies . - pubmed
Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines . - pubmed
In human lung cancer , prostacyclin synthase ( PGIS ) and PGI2 are down - regulated , whereas PGE2 synthase ( PGES ) and PGE2 are up - regulated . - pubmed
Murine carcinogenesis models of human lung cancer reciprocate the relationship between PGIS and PGES expression . - pubmed
PGIS - overexpressing transgenic mice are protected from carcinogen- and tobacco smoke - induced lung tumor formation , suggesting that PGI2 may play a role in chemoprevention . - pubmed
We investigated several potential mechanisms for the down - regulation of PGIS in human lung cancer . - pubmed
In addition , PGIS expression in several human lung cancer cell lines is silenced by CpG methylation , and we have mapped these sites across the variable number of tandem repeats ( VNTR ) sequence in the promoter , as well as CpGs within exon 1 and the first intron . - pubmed
Finally , using fluorescence in situ hybridization , we show that human lung cancer cell lines and lung cancer tissues do not have a loss of the PGIS genomic region but multiple copies . - pubmed
These results show that an individual 's PGIS promoter haplotype can play an important role in the predisposition for lung cancer and CpG methylation provides an epigenetic mechanism for the down - regulated PGIS expression . - pubmed
Involvement and consequences of the proteasomal degradation machinery in the HBc protein turnover during HBV infection with complex HBV variants in the immunosuppressed patients are discussed . - pubmed
ARF occurred in 24 patients ; they tended to be older and hypertensive with lower serum albumin and more proteinuria than those without ARF . - pubmed
The ATP - binding cassette transporter subfamily A member 1 ( ABC - A1 ) and type 2 diabetes : an association beyond HDL cholesterol . - pubmed
Recent findings from several groups demonstrate that ABC - A1 participates in the pathogenesis of the metabolic syndrome and type 2 diabetes . - pubmed
A variant of the ABC - A1 gene ( R230C ) is associated with the metabolic syndrome and its co - morbidities in Mexicans . - pubmed
Moreover , animal models confirm the participation of ABC - A1 in the pathogenesis of diabetes . - pubmed
Mice lacking AbcA1 specifically in beta cells had glucose intolerance at 8 weeks of age . - pubmed
Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22 / Lyp 620Trp variant . - pubmed
The 620Trp variant of the LYP protein , encoded by the lymphoid tyrosine phosphatase 22 gene ( PTPN22 ) , is associated with autoimmunity . - pubmed
We analysed cytokine secretion and proliferation of peripheral blood mononuclear cells ( PBMCs ) and CD4(+)T cells in a cohort of clinically non - diabetic , multiple autoantibody - positive children , healthy controls and in children with type 1 diabetes ( T1D ) . - pubmed
We found a decreased proliferation and IL-2 production of CD4(+)T cells after anti - CD3 / anti - CD28 stimulation ( p=0.04 for IL-2 ) among T1D patients . - pubmed
In contrast , no effect of this polymorphism on tuberculin and tetanus toxoid induced PBMC proliferation and cytokine secretion was observed in autoantibody positive children , healthy controls and children with newly - diagnosed T1D. - pubmed
In conclusion , the LYP 620Trp variant is associated with reduced activation , proliferation and IL-2 production in CD4(+)T cells among T1D patients . - pubmed
The incidence of in - hospital mortality ( 0 % vs. 0.3 % p = 1.000 ) , MI ( 7.1 % vs. 6.6 % ; p = 0.864 ) , and the combined endpoint of death , stroke , emergent coronary artery bypass graft surgery ( CABG)/PCI , or MI ( 7.1 % vs. 6.9 % ; p = 0.868 ) were similar in the bivalirudin - plus - bailout GP IIb / IIIa inhibitor versus the bivalirudin - alone arm . - pubmed
These data suggest that a strategy of bivalirudin monotherapy is preferable in order to reduce bleeding complications , and GP IIb / IIIa blockade should be reserved for patients with periprocedural complications in bivalirudin - treated patients undergoing PCI . - pubmed
Furthermore , we found that the C57BL/6J - like changes in anxiety - related behavior after restraint were absent in null mutants lacking the modulatory NMDA receptor subunit Grin2a , but not the AMPA receptor subunit Gria1 . - pubmed
Association of insulin sensitivity to lipids across the lifespan in people with Type 1 diabetes . - pubmed
RESULTS : Lower glucose infusion rate was significantly associated with lower levels of HDL cholesterol in youths with Type 1 diabetes and with higher levels of triglycerides and higher triglyceride / HDL ratio in both youths and adults . - pubmed
CONCLUSIONS : Lower insulin sensitivity is associated with a more atherogenic lipid profile in both youths and adults with Type 1 diabetes . - pubmed
Low serum myeloperoxidase in autistic children with gastrointestinal disease . - pubmed
AIM : To assess serum myeloperoxidase ( MPO ) levels in autistic children with severe gastrointestinal ( GI ) disease and to test the hypothesis that there is an association between serum MPO concentration and inflammatory GI disease , including antineutrophil cytoplasmic antibodies ( ANCA ) , previously seen in a subgroup of autistic children . - pubmed
SUBJECTS AND METHODS : Serum from 40 autistic children with chronic digestive disease ( most with ileo - colonic lymphoid nodular hyperplasia ( LNH ) and inflammation of the colorectum , small bowel and/or stomach ) , and 48 controls ( 12 age - matched autistic children with no GI disease , 20 age - matched children without autism or GI disease , and 16 nonautistic individuals with no family history of autism ) were tested using enzyme - linked immunosorbent assays designed to quantitate serum MPO levels . - pubmed
MPO serum concentration of autistic children with GI disease was compared to GI disease severity ( including LNH and erythema ) and presence of ANCA . - pubmed
RESULTS : We found that a significant number of autistic children with chronic digestive disease had low serum levels of MPO . - pubmed
DISCUSSION : These results suggest a relationship between low MPO levels and GI disease seen in a subpopulation of autism spectrum disorders individuals . - pubmed
MPO concentration may therefore be a useful biomarker for GI disease in this group of autistic children . - pubmed
In this study , we treated infected CBA mice with cromolyn , an MC stabilizer , and observed much greater parasitemia and interferon - gamma levels , higher mortality , myocarditis , and cardiac damage . - pubmed
Using RT - PCR in purified cardiac MCs , we observed that infection induced transcription of P2X ( 7 ) receptor and Fas , two molecules reportedly involved in cell death and inflammatory regulation . - pubmed
Conversely , infection of P2X ( 7 )(-/- ) mice led to reduced peritoneal , but not cardiac , MC death . - pubmed
Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer ' s disease . - pubmed
Tau is a microtubule - associated protein that forms neurofibrillary tangles ( NFTs ) in the selective vulnerable long projection neurons of the cholinergic basal forebrain ( CBF ) in Alzheimer ' s disease ( AD ) . - pubmed
Although CBF neurodegeneration correlates with cognitive decline during AD progression , little is known about the temporal changes of tau accumulation in this region . - pubmed
We investigated tau posttranslational modifications during NFT evolution within the CBF neurons of the nucleus basalis ( NB ) using tissue from subjects with no cognitive impairment , mild cognitive impairment , and AD . - pubmed
We also investigated the occurrence of pretangle tau events within cholinergic NB neurons by dual staining for the cholinergic cell marker , p75 ( NTR ) , which displays a phenotypic down - regulation within CBF perikarya in AD . - pubmed
As pS422 + neurons increased in number , p75 ( NTR )+ neurons decreased , and these changes correlated with both AD neuropathology and cognitive decline . - pubmed
Methylation status of CpG sites in the MCP-1 promoter is correlated to serum MCP-1 in Type 2 diabetes . - pubmed
AIM : Monocyte chemoattractant protein-1 ( MCP-1 ) is a potent chemokine and plays an important role in atherosclerosis of Type 2 diabetes . - pubmed
The aim of this study was to investigate the methylation status of CpG sites in the MCP-1 promoter in Type 2 diabetic patients and its correlation to serum MCP - 1 level , and blood glucose level . - pubmed
Methylation of CpGmotifs were less methylated in the patients than in the controls ( 25 % vs 80 % ; p<0.001 ) , while the level of MCP-1 in serum was higher in patients with Type 2 diabetes ( 193.95 + -74.96 vs 88.46 + -55.10 ; p<0.001 ) . - pubmed
CONCLUSION : These data suggest that hypomethylation of CpG sites in the MCP-1 promoter region may be affected by blood glucose and TG , which then increase the serum MCP-1 level and may play a role in the vascular complications of Type 2 diabetes . - pubmed
Six of these proteins ( uromodulin , alpha-1 - microglobulin , zinc - alpha-2 - glycoprotein , cystatin C , Ig - kappa - chain , and inter - alpha - trypsin heavy chain H4 ) were strongly correlated with various forms of kidney disorders . - pubmed
Pilot study of the clinical significance of serum and urinary her-2 / neu protein in bladder cancer patients . - pubmed
PURPOSE : HER-2 / neu overexpression is documented in some bladder cancers . - pubmed
Therefore , we examined the clinical significance of serum and urine HER-2 / neu protein in bladder cancer . - pubmed
Urine cytology and serum and urine HER-2 / neu levels were measured before the transurethral resection of bladder tumor procedure . - pubmed
Prognostic factors including tumor stage , histologic grade , tumor size , multiplicity , and preoperative urine cytology and their association with urinary HER-2 / neu were analyzed by simple and multiple regression analyses . - pubmed
The mean urinary HER-2 / neu was 7,586.82 relative luminescence unit ( RLU ) in bladder cancer patients and 4,245.84 RLU in healthy controls . - pubmed
The mean RLU values of urinary HER-2 / neu in the bladder cancer patient group were significantly higher than in healthy controls ( p=0.012 ) . - pubmed
CONCLUSIONS : Bladder cancer patients demonstrated significantly higher urinary HER-2 / neu than did healthy controls . - pubmed
For example , defects in the clearance of self - antigens and chronic stimulation of type 1 interferons lead to the systemic autoimmunity seen in C1q deficiency , SPENCDI , and AGS . - pubmed
Using these SNPs no evidence for causality between the fibrinogen levels and coronary heart diseases was found in instrumental variables analysis . - pubmed
[ Role of PDGF - A / PDGFR - alpha in proliferation and transdifferentiation of fibroblasts from skin lesions of patients with systemic sclerosis ] . - pubmed
OBJECTIVE : To study the role of platelet - derived growth factor A ( PDGF - A)/PDGF receptor - alpha ( PDGFR - alpha ) signaling pathway in the proliferation and transdifferentiation of fibroblasts ( FB ) into myofibroblasts ( MFB ) in the skin lesions of patients with systemic sclerosis ( SSc ) . - pubmed
METHODS : The primary FBs isolated from the skin lesions of SSc patients and normal adult skin cultured in vitro were examined for alpha - smooth muscle actin ( alpha - SMA ) using immunocytochemistry . - pubmed
Below the saturated concentration of PDGF , the FBs in the two groups both proliferated in a dose - dependent manner ( P<0.05 ) , but the FBs from the SSc lesions always showed a significantly higher proliferative activity ( P<0.05 ) . - pubmed
PDGF - AA and TGF - beta ( 1 ) , alone or in combination , up - regulated the expression level of PDGFR - alpha and alpha - SMA mRNA in the FBs from SSc lesions ; similar results were obtained in the control FBs , except that TGF - beta ( 1 ) alone did not influence PDGFR - alpha mRNA expression . - pubmed
Over - expression of PDGFR - alpha on the surface of FBs from SSc lesions can bind more PDGF - AA ligands to increase cell proliferation and promote transdifferentiation to MFB , and TGF - beta ( 1 ) further enhances this effect . - pubmed
However , it is currently unknown how BAG-1 expression is regulated at the molecular level , especially in cancer cells . - pubmed
Furthermore , enhanced FLJ20420 expression was observed in tumor cell lines ( i.e. - pubmed
Finally , our gene array studies in lung cancer tissue samples revealed a significant increase in FLJ20420 expression in primary lung cancer relative to the paired normal lung tissue controls ( p = 0.0006 ) . - pubmed
The increased expression of FLJ20420 corresponded to a significant decrease in BAG-1 protein expression in the primary lung cancers , relative to the paired normal lung tissue controls ( p = 0.0001 ) . - pubmed
Selective blockers of the N - type calcium channel have proven to be effective in animal models of chronic pain . - pubmed
Therefore , the identification of orally active , small - molecule N - type calcium channel blockers would represent a significant advancement in the treatment of chronic pain . - pubmed
Tumor suppressive miR-124 targets androgen receptor and inhibits proliferation of prostate cancer cells . - pubmed
Increased serum osteoprotegerin in patients with primary adrenal insufficiency receiving conventional hydrocortisone substitution . - pubmed
The study was aimed to investigate the effect of steroid substitution on serum osteoprotegerin and receptor activator of nuclear factor kappa - beta ligand ( RANKL ) levels in relation to bone mineral density ( BMD ) in PAI . - pubmed
Mean osteoprotegerin concentration in PAI patients appeared significantly higher vs. controls ( p=0.002 ) , while RANKL levels were similar ( p=0.430 ) . - pubmed
Patients with osteoporosis displayed higher osteoprotegerin levels , but after the age - adjustment the correlation was lost . - pubmed
In conclusion , increased osteoprotegerin in PAI might reflect a compensatory response to enhanced bone resorption due to exogenous steroid excess and/or result from a deficit in adrenal androgens . - pubmed
Association between reduction of plasma adiponectin levels and risk of bacterial infection after gastric cancer surgery . - pubmed
ROC analysis revealed that the useful cutoff values ( sensitivity / specificity ) for preoperative ADN levels , ADN ratio , blood loss , operating time , and CRP levels were 8.81(0.567/0.568 ) , 0.76 ( 0.767/0.761 ) , 405 g ( 0.717/0.693 ) , 342 min ( 0.617/0.614 ) , and 8.94 mg / dl ( 0.583/0.591 ) , respectively . - pubmed
Androgen receptor - independent function of FoxA1 in prostate cancer metastasis . - pubmed
To date , there have been conflicting reports on the role of FoxA1 in prostate cancer progression and prognosis . - pubmed
With recent discoveries of recurrent FoxA1 mutations in human prostate tumors , comprehensive understanding of FoxA1 function has become very important . - pubmed
Using orthotopic mouse models , we further show that FoxA1 inhibits prostate tumor metastasis in vivo . - pubmed
Concordant with these contradictory effects on tumor progression , FoxA1 expression is slightly upregulated in localized prostate cancer wherein cell proliferation is the main feature , but is remarkably downregulated when the disease progresses to metastatic stage for which cell motility and EMT are essential . - pubmed
Taken together , our findings illustrate an AR - independent function of FoxA1 as a metastasis inhibitor and provide a mechanism by which recurrent FoxA1 mutations contribute to prostate cancer progression . - pubmed
OBJECTIVE : The aims of this study were to develop carrageenan - induced hyperalgesia in rhesus monkeys and determine the efficacy and potency of agonists selective for the four opioid receptor subtypes in this model versus acute pain , as compared to non - steroidal anti - inflammatory drugs ( NSAIDs ) . - pubmed
Only fentanyl produced scratching at antihyperalgesic and antinociceptive doses consistent with its pruritic effects in humans , illustrating a translational profile of MOP agonists in nonhuman primates . - pubmed
CONCLUSION : Using two different pain modalities in nonhuman primates , effectiveness of clinically available analgesics like fentanyl , ketorolac and naproxen was distinguished and their efficacies and potencies were compared with the selective KOP , DOP , and NOP agonists . - pubmed
TFDP3 was expressed in coordination with E2F1 to inhibit E2F1 - mediated apoptosis in prostate cancer . - pubmed
TFDP3 expression was assessed by RT - PCR , in situ hybridization and immunohistochemistry in normal human tissues , cancer tissues and prostate cancer tissues . - pubmed
The association between TFDP3 and E2F1 in prostate cancer development was analyzed in various stages . - pubmed
The results show that , in 96 samples of normal human tissues , TFDP3 could be detected in the cerebrum , esophagus , stomach , small intestine , bronchus , breast , ovary , uterus , and skin , but seldom in the lung , muscles , prostate , and liver . - pubmed
In addition , TFDP3 was highly expressed in numerous cancer tissues , such as brain - keratinous , lung squamous cell carcinoma , testicular seminoma , cervical carcinoma , skin squamous cell carcinoma , gastric adenocarcinoma , liver cancer , and prostate cancer . - pubmed
Moreover , TFDP3 was positive in 23 ( 62.2 % ) of 37 prostate cancer samples regardless of stage . - pubmed
Furthermore , immunohistochemistry results show that TFDP3 was always expressed in coordination with E2F1 at equivalent expression levels in prostate cancer tissues , and was highly expressed particularly in samples of high stage . - pubmed
It was demonstrated that TFDP3 was a broadly expressed protein corresponding to E2F1 in human tissues , and suggested that TFDP3 is involved in prostate cancer cell survival by suppressing apoptosis induced by E2F1 . - pubmed
The predictive value of GSTT1 polymorphisms in predicting the early response to induction BCG therapy in patients with non - muscle invasive bladder cancer . - pubmed
INTRODUCTION : We evaluated the predictive value of glutathione S transferase mu ( GSTM1 ) and theta ( GSTT1 ) polymorphisms in early response to bacillus Calmette - Guerin ( BCG ) induction therapy in patients with primary non - muscle invasive bladder cancer . - pubmed
METHODS : GSTM1 and GSTT1 polymorphisms were analyzed by multiplex polymerase chain reaction using blood genomic DNA from 135 patients with primary non - muscle invasive bladder cancer who were being treated with a single induction course of BCG . - pubmed
After stratification based on the tumor stage and grade , the high - risk group ( T1G3 ) with a GSTT1 - positive genotype showed a 14 - fold higher risk of early BCG failure compared with those with a GSTT1 - null genotype . - pubmed
By multivariate logistic regression analysis , the GSTT1 - positive genotype was an independent predictor of early BCG failure ( odds ratio = 3.67 , 95 % CI : 1.61 - 8.38 ) . - pubmed
Kaplan - Meier estimates revealed a significant difference in disease - free survival depending on the GSTT1 genotype ( log rank test , P = 0.038 ) . - pubmed
Here we show that the aryl hydrocarbon receptor ( AhR ) , a transcription factor that senses environmental stimuli , modulates pathology in psoriasis . - pubmed
AhR - activating ligands reduced inflammation in the lesional skin of psoriasis patients , whereas AhR antagonists increased inflammation . - pubmed
Similarly , AhR signaling via the endogenous ligand FICZ reduced the inflammatory response in the imiquimod - induced model of skin inflammation and AhR - deficient mice exhibited a substantial exacerbation of the disease , compared to AhR - sufficient controls . - pubmed
Thus , our data suggest a critical role for AhR in the regulation of inflammatory responses and open the possibility for novel therapeutic strategies in chronic inflammatory disorders . - pubmed
Inhibition of SGK1 enhances mAR - induced apoptosis in MCF-7 breast cancer cells . - pubmed
Functional membrane androgen receptors ( mAR ) have previously been described in MCF-7 breast cancer cells . - pubmed
Our results demonstrate that mAR activation triggers pro - apoptotic responses in breast tumor cells , an effect significantly enhanced by SGK1 inhibition , involving actin reorganization and paralleled by down - regulation of FAK / Akt signaling . - pubmed
Serum HDL level may be a potential candidate predictor for the future risk of suicidality . - pubmed
The mitotic kinesin KIF11 is a driver of invasion , proliferation , and self - renewal in glioblastoma . - pubmed
Inhibition of KIF11 with a highly specific small - molecule inhibitor stopped the growth of the more treatment - resistant glioblastoma tumor - initiating cells ( TICs , or cancer stem cells ) as well as non - TICs and impeded tumor initiation and self - renewal of the TIC population . - pubmed
Targeting KIF11 also hit the other arm of the " go or grow " cell fate decision by reducing glioma cell invasion . - pubmed
Administration of a KIF11 inhibitor to mice bearing orthotopic glioblastoma prolonged their survival . - pubmed
In its role as a shared molecular regulator of cell growth and motility across intratumoral heterogeneity , KIF11 is a compelling therapeutic target for glioblastoma . - pubmed
Univariable analysis revealed that male gender , presence of anti - Scl 70 and absent anti - centromere antibody was significant predictors of ILD . - pubmed
Male gender , presence of anti - Scl 70 , and absent anti - centromere antibody predicted the future development of ILD in early - SSc patients . - pubmed
Two cases of early - onset myoclonic seizures with continuous parietal delta activity caused by EEF1A2 mutations . - pubmed
BACKGROUND : Mutations in the elongation factor 1 alpha 2 ( EEF1A2 ) gene have recently been shown to cause severe intellectual disability with early - onset epilepsy . - pubmed
CONCLUSION : This report provides clinical data on epileptic encephalopathy in patients with EEF1A2 mutation . - pubmed
Impact Study : MK-0646 ( Dalotuzumab ) , Insulin Growth Factor 1 Receptor Antibody Combined with Pemetrexed and Cisplatin in Stage IV Metastatic Non - squamous Lung Cancer . - pubmed
Adenocarcinoma and never - smokers have a higher expression of IGF-1R , which is associated with worse overall survival . - pubmed
Diabetes Caused by Elastase - Cre - Mediated Pdx1 Inactivation in Mice . - pubmed
Along with exocrine defects , including impaired acinar cell maturation , the mutant mice exhibited substantial endocrine defects , including disturbed tip / trunk patterning of the developing ductal structure , a reduced number of Ngn3 - expressing endocrine precursors , and ultimately fewer beta cells . - pubmed
TOX expression and role in CTCL . - pubmed
MF / CTCL have increased expression of thymocyte selection - associated HMG box protein ( TOX ) . - pubmed
Although TOX has been proposed to be a diagnostic marker for MF , further validation studies are needed . - pubmed
Moreover , it is unclear what drives TOX expression or its role in MF / CTCL . - pubmed
OBJECTIVE : We hypothesize evaluation of TOX levels across a spectrum of CTCL , including MF precursor ( large plaque parapsoriasis , LPP ) , will help elucidate the implications of altered TOX expression . - pubmed
MATERIALS AND METHODS : TOX staining was performed in MF , CD30(+ ) LPD , LPP as well as benign inflammatory dermatoses ( BID ) and normal skin ( NS ) . - pubmed
RESULTS : Positive TOX expression was identified in 73.6 % of MF cases and in 31.6 % of BID / NS . - pubmed
TOX expression in MF was detected more commonly in Black patients ( P = 0.015 ) and less commonly in transformed MF ( P = 0.045 ) . - pubmed
In CTCL cells , GATA3 knockdown decreased TOX mRNA and protein expression . - pubmed
CONCLUSION : Our data indicate that TOX is useful as a diagnostic marker in MF . - pubmed
Moreover , TOX expression was evident in LPP , indicating it may have a previously unappreciated role in the development of MF . - pubmed
Epidermal Growth Factor Receptor Mutation Enhances Expression of Cadherin-5 in Lung Cancer Cells . - pubmed
Epidermal growth factor receptor ( EGFR ) activation has been shown to play a critical role in tumor angiogenesis . - pubmed
In this study , we investigate the correlation between EGFR mutations and cadherin-5 ( CDH5 ) , which is an angiogenic factor , in lung cancer cells . - pubmed
Increased expression CDH5 is observed in lung cancer cells with EGFR mutations . - pubmed
Stable lung cancer cell lines expressing mutant ( exon 19 deletion E746 - A750 , and exon 21 missense mutation L858R ) and wild type EGFR genes are established . - pubmed
A significantly higher expression of CDH5 is observed in exon 19 deletion stable lung cancer cells and mouse xenografts . - pubmed
Further studies show that expression of CDH5 is decreased after the inhibition of EGFR and downstream Akt pathways in lung cancer cells with EGFR mutation . - pubmed
In addition , mutant EGFR genes potentiates angiogenesis in lung cancer cells , which is inhibited by CDH5 siRNA , and potentiates migration and invasion in lung cancer cells . - pubmed
Our result may provide an insight into the association of mutant EGFR and CDH5 expression in lung cancer and aid further development of target therapy for NSCLC in the future . - pubmed
Transgenic knockout of either claudin gene causes hypotension , hypochloremia , and metabolic alkalosis in experimental animals . - pubmed
Kelch - like 3 , previously identified as a causal gene for Gordon ' s syndrome , also known as pseudohypoaldosteronism II , directly interacts with claudin-8 and regulates its ubiquitination and degradation . - pubmed
Deregulation of claudins may cause human hypertension as exemplified in the Gordon ' s syndrome . - pubmed
Five hours after the procedure , the whole cornea was excised and subjected to image analysis for corneal edema , real - time semiquantitative PCR ( qPCR ) for heme oxygenase ( HO )- 1 , catalase ( CAT ) , superoxide dismutase 1 ( SOD1 ) , and SOD2 mRNA , and immunohistochemistry . - pubmed
Corneal edema was significantly less and the increases in anti - oxidative HO-1 , CAT and SOD2 mRNA expressions were significantly suppressed in the H2 group . - pubmed
The MET / Vascular Endothelial Growth Factor Receptor ( VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS - dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer . - pubmed
The tyrosine kinase inhibitor TAS-115 that blocks VEGF receptor and hepatocyte growth factor receptor MET signaling exhibits antitumor properties in xenografts of human gastric carcinoma . - pubmed
Our study indicates that tyrosine kinase signaling in host pre - osteoclasts / osteoclasts is critical for bone destruction induced by tumor cells and that targeting of MET / VEGF receptor / FMS activity makes it a promising therapeutic candidate for the treatment of prostate cancer patients with bone metastasis . - pubmed
Effects of an alpha1A / D - adrenoceptor antagonist , naftopidil , and a phosphodiesterase type 5 inhibitor , tadalafil , on urinary bladder remodeling in rats with spinal cord injury . - pubmed
AIMS : In order to clarify whether an alpha1A / D - adrenoceptor ( alpha1 A / D - AR ) antagonist , naftopidil , or a phosphodiesterase type 5 ( PDE5 ) inhibitor , tadalafil , prevents bladder wall remodeling after spinal cord injury ( SCI ) , we examined the bladder and urethral activity as well as ischemic and fibrotic changes in the bladder using SCI rats with or without naftopidil or tadalafil treatment . - pubmed
Bladder and urethral pressures , mRNA levels of fibrosis - related molecules and ischemia markers and the composition of bladder collagen and elastin were evaluated . - pubmed
RESULTS : Naftopidil treatment reduced the upregulation of mRNA levels of ischemia and fibrosis markers at the early phase of SCI , and ameliorated the decrease of bladder compliance and voiding efficiency , and the increase of urethral pressure and collagen concentration in the bladder wall at the late phase of SCI . - pubmed
Tadalafil treatment reduced the upregulation of mRNA levels of fibrosis markers , the decrease of bladder compliance and the increase of collagen concentration at the late phase of SCI . - pubmed
CONCLUSIONS : These results suggest that naftopidil and tadalafil treatments improved the bladder remodeling shown by increased bladder collagen contents after SCI in a different time course . - pubmed
BACKGROUND : Celecoxib is a selective cyclo - oxygenase-2 inhibitor recommended orally to treat arthritis and osteoarthritis . - pubmed
Association between AXL , Hippo Transducers , and Survival Outcomes in Male Breast Cancer . - pubmed
We have previously reported that the expression of the Hippo transducers TAZ / YAP and their target CTGF was associated with inferior survival in MBC patients . - pubmed
Thus , we herein assessed AXL expression to further investigate the significance of active TAZ / YAP - driven transcription in MBC . - pubmed
Patients with TAZ / CTGF / AXL- or YAP / CTGF / AXL - expressing tumors had inferior survival compared with non - triple - positive patients ( log rank P = 0.042 and P = 0.048 , respectively ) . - pubmed
The expression pattern of AXL corroborates the idea of the detrimental role of TAZ / YAP activation in MBC . - pubmed
Here , we determined the expression pattern of FOXO in healthy and degenerated human IVD and the associations with IVD degeneration during mouse aging . - pubmed
Mouse spines were graded for key histological features of disc degeneration in all the time points and expression of two key FOXO downstream targets , sestrin 3 ( SESN3 ) and superoxide dismutase ( SOD2 ) , was assessed by immunohistochemistry . - pubmed
The reduction of spontaneous epileptiform bursting in the CA3 is correlated to a reduction in pilocarpine - induced SE in vivo in TRPC7 knockout mice . - pubmed
Although the pilocarpine - induced SE itself is not significantly reduced , the SE - induced neuronal cell death is significantly reduced in the CA1 and the lateral septum , indicating that TRPC1 / 4 channels directly contribute to SE - induced neuronal cell death . - pubmed
Genetic ablation of TRPC5 also reduces SE - induced neuronal cell death in the CA1 and CA3 areas of the hippocampus . - pubmed
METHODS : In this study , we evaluated the inhibitory effects of GS - E3D on the formation of advanced glycation end products ( AGEs ) and their cross - linking with collagen in vitro and in streptozotocin - induced diabetic rats . - pubmed
HLA class I expression predicts prognosis and therapeutic benefits from tyrosine kinase inhibitors in metastatic renal - cell carcinoma patients . - pubmed
PURPOSE : Classical HLA class I antigen is highly involved in antigen presentation and adaptive immune response against tumor . - pubmed
EXPERIMENTAL DESIGN : A TKI cohort of 111 mRCC patients treated with sunitinib or sorafenib and a non - TKI cohort of 160 mRCC patients treated with interleukin-2 or interferon - alpha - based immunotherapy at a single institution were retrospectively enrolled . - pubmed
HLA class I expression was associated with CTL infiltration and function , and its prognostic value was more predominant in CTL high - density tumors ( P & lt ; 0.001 ) rather than CTL low - density tumors ( P = 0.294 ) . - pubmed
CONCLUSIONS : Classical HLA class I expression can serve as a potential predictive biomarker for TKI therapy in mRCC patients . - pubmed
HIL group patients had higher albumin ( 3.3 vs. 2.9 g / dL ; P<0.001 ) and lower C - reactive protein ( 6.4 vs. 8.1 mg / L ; P<0.001 ) postoperatively . - pubmed
Brain - derived neurotrophic factor ( BDNF ) is a crucial regulator to support synaptic plasticity and neuronal survival , its significant decrease is a pathophysiological hallmark in Alzheimer ' s disease ( AD ) brains and accounts for poor prognosis . - pubmed
Here we observed miR-322 is significantly increased along with BDNF decrease in AD mouse brain . - pubmed
Collectively , this study demonstrated a novel miRNA - dependent manner of BDNF degradation in AD pathogenesis , it may drive a miRNAs- or BDNF based therapeutic strategies against Alzheimer ' s disease . - pubmed
Correction : Synergistic Interaction between the HDAC Inhibitor , MPT0E028 , and Sorafenib in Liver Cancer Cells In Vitro and In Vivo . - pubmed
Sympathetic nervous remodeling is induced in the intermediolateral nucleus after myocardial infarction - Role of BDNF - TrkB axis . - pubmed
The mRNA and protein expressions of brain - derived neurotrophic factor ( BDNF ) , tropomyosin - related kinase receptor ( TrkB ) and extracellular signal - regulated kinase ( ERK ) were measured by quantitative RT - PCR , immunohistochemistry and Western blotting 1 week after MI . - pubmed
The density of growth - associated protein-43 , a protein upregulated in axons undergoing nerve sprouting , was increased after MI compared to sham . - pubmed
The fluorescence intensity of BDNF and TrkB in IML were significantly higher in the MI group than in the sham group . - pubmed
In addition , mRNA expressions of BDNF and TrkB in the spinal cord at the Th2 level was increased after MI . - pubmed
In conclusion , neural remodeling after MI in IML is associated with the activation of BDNF - TrkB axis . - pubmed
RESULTS : IgM and IgG donor - specific isoagglutinins ( DSIs ) of 31 cases of TPE were significantly decreased after three consecutive TPEs ( IgM median , 1:32 to 1:2 , P & lt ; .0001 ; IgG median , 1:256 to 1:8 , P & lt ; .0001 ) . - pubmed
Here , to better understand the pathogenesis of MERS - CoV , we studied the role of pyroptosis in THP-1 cells and hDPP4 Tg mice with MERS - CoV infection . - pubmed
The hDPP4 - Tg mice infected with MERS - CoV overexpressed caspase-1 in the spleen and showed high IL-1beta levels in serum , suggesting that pyroptosis occurred after infection . - pubmed
Pyroptosis and inflammation were suppressed by inhibiting C5aR1 . - pubmed
Stronger suppression of the digestive protease gene CatL and elevated basal expression of the stress responsive gene Hsp27 were observed in F1 larvae with parental hypoxic experience . - pubmed
Effects of thalidomide on Th17 , Treg cells and TGF - beta1 / Smad3 pathway in a mouse model of systemic sclerosis . - pubmed
OBJECTIVE : To evaluate the immune regulatory and anti - fibrosis function of thalidomide ( Thal ) in systemic sclerosis ( SSc ) , we investigated the effects of Thal on : ( a ) Th17 and Treg cell production ; ( b ) related factors expression ; and ( c ) transforming growth factor ( TGF )- beta1 / Smad3 pathway , using a mouse model of SSc . - pubmed
RESULTS : Thal treatment : ( a ) reduced skin , and pulmonary tissue fibrosis , inflammation score , and hydroxyproline content ( P & lt ; .001 ) in BLM - induced SSc mice ; ( b ) reduced the percentages of Th17 cells and associated interleukin ( IL )- 17A expression ( both P & lt ; .05 ) but increased the percentages of Treg cells and its transcription factor Foxp3 expression ( both P & lt ; .05 ) ; ( c ) correlation analysis found positive correlations between Th17 / Treg ratio , the inflammatory score of the skin and pulmonary tissues , hydroxyproline content , and type I collagen messenger RNA expression ( r = .8546 , .8656 , .6902 , .6807 , .8118 , and .8424 , respectively , P & lt ; .01 ) ; ( d ) Thal inhibited TGF - beta1 expression and Smad3 phosphorylation ( both P & lt ; .05 ) ; ( e ) TGF - beta1 was positively correlated with the IL-17A and Th17 / Treg ratio ( r = .5856 , P = .005 ; r = .6684 , P = .0107 , respectively ) . - pubmed
CONCLUSION : Thal can effectively prevent skin and pulmonary tissue fibrosis in a mouse model of SSc through the TGF - beta1 / Smad3 signaling pathway and can rectify the distortion of the Th17 / Treg balance in SSc by potentially regulating Th17 and Treg cell production , as well as their related factors expression . - pubmed
Influence of the Hippo - YAP signalling pathway on tumor associated macrophages ( TAMs ) and its implications on cancer immunosuppressive microenvironment . - pubmed
The Hippo - Yes - associated protein ( YAP ) signalling pathway is one of the most extensively discussed mechanism for the regulation of tumour proliferation , migration , angiogenesis , and invasion in recent years . - pubmed
To date , several studies have revealed that YAP is involved in the interrelating interactions between tumour and immune cells , particularly the TAMs . - pubmed
Caveolar activation counteracted the expression of wound - protective epidermal growth factor receptor ( EGFR ) and its target genes , such as chemokines that were pivotal for epithelial integrity in the ribosome - inactivated gut . - pubmed
Mechanistic findings regarding ribosomal inactivation - associated disorders in the gut barrier provide crucial molecular evidence for detrimental caveolar actions against EGFR - mediated epithelial protection in patients with IBD . - pubmed
CD123+CD4+CD56 + neoplasm : blastic plasmacytoid dendritic cell neoplasm or acute myeloid leukemia ? - pubmed
Different measurements of thyroid function including I123 thyroid scanning were performed in 16 hypothyroid infants diagnosed by a TSH screening project . - pubmed
Thyroglobulin may have a role in the diagnosis of athyrosis . - pubmed
The levels of C3 , cholinesterase , albumin and prothrombin were determined in 46 patients ( 27 males and 19 females ) - 26 with cirrhosis of the liver , 9 with acute hepatitis , 6 with chronic aggressive hepatitis , 1 with chronic persistent hepatitis and 4 with fatty liver . - pubmed
In all patients and , particularly in those with cirrhotic liver , it was shown that the normal or pathological level of serum C 3 is related both qualitatively and quantitatively to the normal or pathological levels of cholinesterase , albumin , and prothrombin . - pubmed
The determination of the range of confidence for the 4 parameters showed that , in the patients with hepatic coma , cholinesterase reacted most sensitively to liver damage ( 0.5 - 0.94 ) followed by C3 and prothrombin ( 0.33 - 0.81 ) . - pubmed
Also in the cases without hepatic coma , cholinesterase was the most sensitive indicator ( 0.05 - 0.29 ) , followed by prothrombin ( 0.03 - 0.24 ) , albumin and C3 ( 0.00 - 0.16 ) . - pubmed
We analyzed weight of body , spleen and thymus ; antibody response and delayed - type hypersensitivity response to ovalbumin immunization ; and ( immuno)histopathology of spleen , lymph nodes , and lymphoid tissue along the gastrointestinal tract . - pubmed
Rather , the response in primo - infection to Rat Corona Virus , Sendai Virus , and Pneumonia Virus of Mice was the highest in animals clustered as " fast - and high " responders to ovalbumin . - pubmed
The aim of the present study was to see if female alcoholics had low platelet MAO activity and whether there was a correlation between low MAO activity in female alcoholics and specific clinical characteristics often observed in type II male alcoholics . - pubmed
Type II alcoholics were characterized by early onset , a high frequency of depression and alcoholism in first degree relatives , a high frequency of drug abuse and social complications , sensation seeking behavior , extraversion , impulsive sensation seeking psychopathy , and low platelet MAO activity . - pubmed
They did not have early onset , higher frequency of depression or alcoholism in their first degree relatives , nor more social complications than the female alcoholics with normal platelet MAO activity . - pubmed
We have studied methanol - utilization in a peroxisome - deficient ( PER ) mutant of Hansenula polymorpha . - pubmed
In this study , HBsAg , HBcAg and HBV DNA in myeloid cells of 57 patients with hepatitis have been examined by using ABC staining method . - pubmed
The results show that in the myeloid cells of 54 patients with positive HBVM in serum , there are 4 cases with HBV positive antigen , HBcAg has been found in a case of acute hepatitis and HBsAg in a case of chronic hepatitis and a case of liver cirrhosis respectively , HBsAg and HBcAg were found simultaneously in another case of liver cirrhosis . - pubmed
Interaction of 1,25 - dihydroxyvitamin D and plasma renin activity in high renin essential hypertension . - pubmed
In 10 subjects with high renin hypertension , an increase in dietary sodium intake resulted in an increase in urinary calcium excretion ( 2.5 to 3.4 mmol / L , P = .011 ) and an increase in serum 1,25 - dihydroxyvitamin D ( 51.2 to 61.0 pmol / L , P = .045 ) . - pubmed
Therefore , 1,25 - dihydroxyvitamin D may be a mediator in the response of high renin hypertension to increased sodium intake . - pubmed
We reported a 34 - year - old female patient with refractory idiopathic thrombocytopenic purpura ( ITP ) in whom a subacute subdural hematoma occurred without any preceding trauma during danazol administration which resulted in a marked decrease of plasma fibrinogen level . - pubmed
Structural aberrations of the retinoblastoma locus ( RB1 ) were observed in 25 % of breast tumor cell lines studied and 7 % of the primary tumors . - pubmed
No obvious defect in RB1 was detected by DNA blot analysis in primary tumors or cell lines from Wilms ' tumor , cervical carcinoma , or hepatoma . - pubmed
These results further support the concept that the human RB1 gene has pleiotropic effects on specific types of cancer . - pubmed
[ Arterial hypertension in renin - producing retroperitoneal leiomyosarcoma ] . - pubmed
A case report of an extrarenal retroperitoneal metastatic leiomyosarcoma with associated paraneoplastic renin production is presented . - pubmed
Due to the renin excess syndrome , accelerated hypertension was present combined with the signs of secondary hyperaldosteronism , hypokalemia , and alkalosis . - pubmed
In contrast to other publications of extrarenal malignoma with paraneoplastic renin activity , this case elucidates a histologically close relationship to epitheloid muscle cells of kidney vasa afferentia and derived benign tumors . - pubmed
In contrast to histological criteria only the primary tumor exhibited high renin activity , no activity could be detected in the metastase . - pubmed
Lactoferrin in synovial fluid of patients with inflammatory arthritis . - pubmed
Fecal chymotrypsin concentrations were subnormal in five patients with chronic pancreatitis , borderline in one patient with relapsing pancreatitis , subnormal in one patient after pancreatectomy , and subnormal in five of nine with carcinoma of the pancreas . - pubmed
Subnormal concentrations of fecal chymotrypsin were found in seven of 21 patients with chronic liver disease related to alcoholism , eight of 32 with a partial gastrectomy , three of 10 with adult celiac disease and five of 16 with psoriasis . - pubmed
It appears that the determination of fecal chymotrypsin concentrations provides a valuable screening test for pancreatic exocrine deficiency . - pubmed
Failure of short - term hyperprolactinaemia to increase the number of gonadotrophin receptors in the ram testis . - pubmed
( 1 ) The usefulness of complement fixation antigen ( CFA ) antibodies , nuclear inclusion antigen ( NIA ) antibodies and pre - early nuclear antigen ( PENA ) antibodies in serum as markers for serological diagnosis of CMV infection was evaluated from the viewpoint of sensitivity of CF , IF , and ACIF antibody detection methods . - pubmed
Enzymatic activity of renin in plasma of normal and uraemic subjects . - pubmed
PRR is increased in plasma of patients with renal failure compared with that of normal subjects . - pubmed
The present study was carried out to determine if increased PRR in uraemic plasma is related to differences of endogenous active or inactive renin , endogenous renin substrate , or pH of the incubation in vitro . - pubmed
PRR in plasma of ten uraemic patients was greater ( P less than 0.02 ) than that in plasma of ten normal subjects in incubations carried out at pH 7.4 and 5.7 . - pubmed
After addition of renin , renin concentration ( measured by direct radioimmunoassay ) did not differ in normal and uraemic plasma . - pubmed
These observations are consistent with our earlier hypothesis that there is a deficiency of a renin inhibitor in uraemic plasma . - pubmed
Nitric oxide synthase and VIP distribution in enteric nervous system in idiopathic chronic constipation . - pubmed
Idiopathic chronic constipation has been correlated to neural abnormalities that consist of a reduced number of myenteric plexus neurons and a decreased concentration of VIP - positive nerve fibers within the circular muscle . - pubmed
The density of VIP- and nitric oxide - producing neurons was evaluated by immunocytochemistry using anti - VIP and anti - nitric oxide synthase antibodies in five patients with idiopathic chronic constipation . - pubmed
Distinct patterns of expression of intercellular adhesion molecule-1 , vascular cell adhesion molecule-1 , and endothelial - leukocyte adhesion molecule-1 in renal disease . - pubmed
Expression of intercellular adhesion molecule-1 was significantly increased on parietal epithelium of glomeruli in membranous nephropathy and Henoch - Schonlein purpura , on mesangium in Henoch - Schonlein purpura , membranoproliferative glomerulonephritis and IgA nephropathy , and in small interstitial vessels in membranous nephropathy and membranoproliferative glomerulonephritis . - pubmed
Interstitial infiltrates contained only few intercellular adhesion molecule-1 - positive cells in Henoch - Schonlein purpura and IgA nephropathy . - pubmed
Kidneys with lupus nephritis and Henoch - Schonlein purpura demonstrated an increase of endothelial - leukocyte adhesion molecule-1 on parietal epithelium of glomeruli and on tubular epithelium . - pubmed
CONCLUSIONS : These results show for the first time ( a ) endothelial vascular cell adhesion molecule-1 induction in various glomerulonephritides and ( b ) endothelial - leukocyte adhesion molecule-1 induction in the kidney . - pubmed
Histological examination of the tumor revealed a fasciculated proliferation of spindle cells that proved to be immunoreactive to vimentin only ; pleomorphism was mild , necrosis extensive and mitotic count high . - pubmed
We conclude that periplasmic Cu , Zn SOD contributes to the virulence of Neisseria meningitidis , most likely by reducing the effectiveness of toxic oxygen host defenses . - pubmed
OBJECTIVE : The present study was designed to prove the existence of apoptosis in retinoblastoma ( Rb ) and to determine the pathogenic mechanism of spontaneous regression of Rb as well as the relationship between them . - pubmed
[ The effect of pharmacologic prophylaxis with Panpal on acetylcholinesterase activity in the diaphragm and various parts of the brain in rats during treated and untreated Soman poisoning ] . - pubmed
METHODS AND RESULTS : The influence of the pharmacological prophylaxis with Panpal ( pyridostigmine in combination with benaetyzine and trihexyphenidyle ) on acetylcholinesterase activity in diaphragm and various parts of brain at 1 and 3 h following non - treated and treated ( the oxime HI-6 in combination with atropine ) soman poisoning was tested on male rats . - pubmed
While Panpal did not significantly influence the acetylcholinesterase activity in brain following non - treated as well as treated soman poisoning . - pubmed
Panpal increased so many - induced acetylcholinesterase inhibition following non - treated poisoning and decreased the reactivating effect of the oxime HI-6 following treated soman poisoning in diaphragm . - pubmed
CONCLUSIONS : Our data confirm the importance of the combination of reversible acetylcholinesterase inhibitor pyridostigmine with anticholinergic drugs in the pharmacological prophylaxis of soman poisoning because of the elimination of consequences of pyridostigmine - induced increasing in acetylcholinesterase inhibition in the peripheral compartment . - pubmed
Measurements were made before stopping treatment , at discontinuation of GH treatment , and two weeks , six months , and one year later in 11 adolescents with growth hormone deficiency ( GHD ) and five adolescents without GHD who were treated with GH . - pubmed
RESULTS : During the nine months before discontinuation of GH there were no changes in body composition , RMR , or BMC of patients with GHD , nor differences when compared with controls . - pubmed
RMR was reduced by 11.3 kJ / kg fat free mass two weeks after stopping GH in GHD patients and remained suppressed thereafter compared with controls . - pubmed
Percentage body fat increased by 4.3%/year in patients with GHD after discontinuing GH , whereas no changes were noted in control or non - GHD patients at one year . - pubmed
The high amount of sMR released by DC and its ability to bind mannosylated ligand might indicate that this molecule plays a role in the transport of mannosylated proteins from the site of inflammation to other parts of the body . - pubmed
Is isolated idiopathic pancreatitis associated with CFTR mutations ? - pubmed
It is concluded that orexin - A may play an important physiological role in regulating the sleep - wake state , a hypothesis considerably strengthened by the recently reported narcoleptic phenotype of prepro - orexin ( the precursor for orexin - A ) knockout mice . - pubmed
Suppressive effects of dominant negative ras mutant N116Y on transformed phenotypes of human bladder cancer cells . - pubmed
To investigate the suppressive effect of dominant negative H - ras mutant N116Y on transformed phenotypes , we established two N116Y ras mutant stable transfectant clones ( C5 , C13 ) of human bladder cancer cell line , UMUC-2 . - pubmed
Cardiac operation in a patient with combined homozygous protein C and protein S deficiency . - pubmed
Although this did not impact on cerebral perfusion or clinical outcome in patients with acute ischemic stroke in this report , we propose that ER deserves to be further evaluated by initiating the first treatment within 6 h post - insult . - pubmed
Interleukin-12 in the treatment of chronic hepatitis B and C. Interleukin-12 plays a central role in mounting an effective cellular immune response directed towards elimination of intracellular pathogens . - pubmed
In two open label , multicenter , dose - escalation phase I / II studies tolerability , pharmacokinetics , pharmacodynamics , and efficacy of subcutaneously administered recombinant human interleukin-12 ( rHuIL-12 ) was assessed in the treatment of chronic hepatitis B and C. Forty - six patients with chronic hepatitis B and 60 patients with chronic hepatitis C were treated for 12 and 10 consecutive weeks , respectively . - pubmed
ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy . - pubmed
PURPOSE : To test the hypotheses of whether the relative mRNA expression of the thymidylate synthase ( TS ) gene and the excision cross - complementing ( ERCC1 ) gene are associated with response to and survival of fluorouracil ( 5 - FU )/ oxaliplatin chemotherapy in metastatic colorectal cancer . - pubmed
cDNA was derived from paraffin - embedded tumor specimens to determine TS and ERCC1 mRNA expression relative to the internal reference gene beta - actin using fluorescence - based , real - time reverse transcriptase polymerase chain reaction . - pubmed
RESULTS : The median TS gene expression level from 50 metastasized tumors was 3.4 x 10(-3 ) ( minimum expression , 0.18 x 10(-3);maximum expression , 11.5 x 10(-3 ) ) , and the median ERCC1 gene expression level was 2.53 x 10(-3 ) ( minimum , 0.0 ; maximum , 14.61 x 10(-3 ) ) . - pubmed
The gene expression cutoff values for chemotherapy nonresponse were 7.5 x 10(-3 ) for TS and 4.9 x 10(-3 ) for ERCC1 . - pubmed
CONCLUSION : These data suggest that intratumoral ERCC1 mRNA and TS mRNA expression levels are independent predictive markers of survival for 5 - FU and oxaliplatin combination chemotherapy in 5 - FU - resistant metastatic colorectal cancer . - pubmed
As well as the classical mucosa - associated lymphoid tissue cellular infiltrate , immunohistochemical characterization of the 14 mucosa - associated lymphoid tissue - type lymphomas revealed the CD20+/CD43 + centrocyte - like cell phenotype in 10 cases ( 71.5 % ) . - pubmed
Although the lymphoepithelial lesions observed in all lymphomatous cases have been reported in lung lymphoid hyperplasia , the determination of B - cell CD20+/CD43 + phenotype of the intraepithelial lymphocytes highly increased the specificity of lymphoepithelial lesions . - pubmed
We show that 17beta - E2 represses EGF - induced activation of the Raf - to - Erk pathway in human breast carcinoma cells that express GPR30 , including MCF-7 and SKBR3 cells which express both or neither , ER , respectively . - pubmed
Extensive labelling for the apoptotic markers calcium channel receptor P2X ( 7 ) and caspase-3 and telomerase activity was co - localized at a similar intensity in areas affected by superficial spreading melanoma obtained from 80 patients . - pubmed
Conversely , the calcium - regulating receptors P2X ( 1 - 3 ) and P2Y ( 2 ) ( found in normal but not neoplastic skin ) were fully de - expressed within 2 microm of the melanoma but fully expressed beyond that distance . - pubmed
The cell adhesion protein E - cadherin ( also only present in normal skin ) was progressively de - expressed from a point 2 microm from the melanoma until full de - expression within the lesion . - pubmed
These results show that telomerase - induced proliferation and defensive apoptosis are co - localized and simultaneous processes in melanoma tissue . - pubmed
Melanoma cell proliferation appears to overwhelm the apoptotic defence , perhaps due to the anti - apoptotic effects of telomerase . - pubmed
[ Prolonged insulin coma ; therapeutic effect of ANP-235 ] . - pubmed
There was no convincing evidence of reaccumulation of iron in the grafted liver in HH ; however , 1 subject demonstrated increased serum ferritin concentration and grade 2 hepatic siderosis . - pubmed
Studies of bone turnover in women with sustained exercise - associated amenorrhea using metabolic markers of osteoblast activities and collagen synthesis have demonstrated an apparent reduction of bone formation that is associated with a low body mass index ( BMI ) and with endocrine disturbances that are characteristic of energy deficit . - pubmed
Moreover , a number of pathological and pharmacological studies on sporadic PD and dopaminergic neurotoxin - induced parkinsonism have hypothesized that mitochondrial dysfunction , inflammation , oxidative stress , and dysfunction of the ubiquitin - proteasome system all play important roles in the pathogenesis and progress of PD . - pubmed
Intravenous thrombolysis with recombinant tissue plasminogen activator is the established treatment for acute ischemic stroke patients presenting within 3 h after stroke onset . - pubmed
Only one case with a somatic MEN1 mutation was identified ( 1527del7bp ) , indicating that the MEN1 gene plays a minor pathogenic role in sporadic insulinomas . - pubmed
The results allow an understanding of the active site specificity of the C1s protease for the first time and provide a basis for the development of specific inhibitors aimed at controlling inflammation associated with complement activation in adverse pathological situations . - pubmed
The encouraging responses seen in this early study suggest further evaluation of epidermal growth factor receptor and cyclooxygenase-2 inhibitors in SCCHN is warranted . - pubmed
Ghrelin improves endothelial function in patients with metabolic syndrome . - pubmed
This study therefore investigated whether ghrelin administration might beneficially affect endothelial function in metabolic syndrome . - pubmed
In patients with metabolic syndrome , basal plasma ghrelin was significantly lower than in controls ( P=0.02 ) . - pubmed
This effect was likely related to enhanced nitric oxide bioavailability because , in a group of patients with metabolic syndrome ( n=6 , 2 female ) , ghrelin had no effect on the vasodilator response to acetylcholine ( P=0.78 versus saline ) after nitric oxide inhibition by NG - monomethyl - L - arginine . - pubmed
CONCLUSIONS : These findings indicate that ghrelin reverses endothelial dysfunction in patients with metabolic syndrome by increasing nitric oxide bioactivity , thereby suggesting that decreased circulating levels of the peptide , such as those found in these patients , might play a role in the pathobiology of atherosclerosis . - pubmed
Neutralizing antibody responses of pigs infected with natural GP5 N - glycan mutants of porcine reproductive and respiratory syndrome virus . - pubmed
In order to assess the effect of the N - glycans associated with the GP5 neutralization epitope of porcine reproductive and respiratory syndrome virus ( PRRSV ) on the neutralizing antibody ( Ab ) response of swine , groups of young pigs were infected with PRRSV strains differing in N - glycosylation pattern . - pubmed
In addition , viremia was monitored by quantitative RT - PCR , and anti - N - protein Ab formation was measured by HerdChek ELISA . - pubmed
Some pigs generated high titers of peptide binding Abs between 7 and 28 days post infection ( p.i . ) - pubmed
In the present study we have studied the in vitro effects of hyperbaric oxygen on proliferation of human fibroblasts from normal skin and from chronic foot ulcers in non - insulin - dependent diabetics . - pubmed
Even though there are some critical obstacles to inhibit effective tumour immunity , tumour cells are able to exploit the functional roles of iDCs for tumour progression , which are induced by tumour - derived soluble factors such as vascular endothelial growth factor ( VEGF ) and functionally modulated in the microenvironment . - pubmed
These fractions induced DNA ladder and caspase-3 activation during apoptosis in colon 26 tumor cells . - pubmed
These results indicate that the dichloromethane extract of PBL includes anticancer components composed of at least three fatty acids , and apoptosis - inducing activity of the extract was mediated by caspase-3 activation in tumor cells . - pubmed
Examining the relationship between Cu - ATSM hypoxia selectivity and fatty acid synthase expression in human prostate cancer cell lines . - pubmed
METHODS : Human prostate tumor - cultured cell lines ( PC-3 , 22Rv1 , LNCaP and LAPC-4 ) , were treated with a fatty acid synthase ( FAS ) inhibitor ( C75 , 100 microM ) under anoxia . - pubmed
CONCLUSIONS : Although Cu - ATSM has clinical relevance in the PET imaging of hypoxia in many tumor types , its translation to the imaging of prostate cancer may be limited by the overexpression of FAS associated with prostatic malignancies . - pubmed
Association , expression , pathobiology : is too much tau in PD a blueprint for genetic association ? - pubmed
Laboratory investigation of the initial 29 suspect - case blood specimens by classic methods ( antigen capture , IgM and IgG ELISA ) and a recently developed random - primed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species ( Bundibugyo ebolavirus ) distantly related to the Cote d'Ivoire ebolavirus found in western Africa . - pubmed
Evaluation of an interferon - gamma release assay , T - SPOT.TB , in a population with a low prevalence of tuberculosis . - pubmed
OBJECTIVE : To compare the performance of an interferon - gamma release assay ( T - SPOT.TB ) and tuberculin skin test ( TST ) in a population with a low prevalence of tuberculosis ( TB ) that was predominantly US - born and not bacille Calmette - Guerin - vaccinated . - pubmed
INH - associated hepatitis ( INH - hepatitis ) was defined as having either alanine or aspartate aminotransferase greater than 5.0 times the upper limit of normal regardless of symptoms when INH was not excluded as the cause . - pubmed
RESULTS : Concentrations of small HDL particles were lower in patients with RA ( 18.2 + /- 5.4 nmol / l ) than controls ( 20.0 + /- 4.4 nmol / l ; p = 0.003 ) . - pubmed
In patients with RA , small HDL concentrations were inversely associated with DAS28 ( rho = -0.18 , p = 0.04 ) and C - reactive protein ( rho = -0.25 , p = 0.004 ) . - pubmed
Concentrations of small HDL were lower in patients with coronary calcification ( 17.4 + /- 4.8 nmol / l ) than in those without ( 19.0 + /- 5.8 nmol / l ; p = 0.03 ) . - pubmed
Concentrations of small LDL particles were lower in patients with RA ( 1390 + /- 722 nmol / l ) than in controls ( 1518 + /- 654 nmol / l ; p = 0.05 ) , but did not correlate with DAS28 or CAC . - pubmed
CONCLUSION : Low concentrations of small HDL particles may contribute to increased coronary atherosclerosis in patients with RA . - pubmed
We further discuss mechanisms by which inhibition of PAK1 can arrest tumor growth and promote cell apoptosis , and the types of cancers in which PAK1 inhibition may hold promise . - pubmed
BACKGROUND : Secondary hyperparathyroidism ( SHPT ) , known complication of chronic renal failure , in addition to effects on bone and cardiovascular systems , is associated with reduced response to erythropoietin ( EPO ) . - pubmed
PATIENTS AND METHODS : Using a retrospective chart - based review of dialysis patients ' records to identify patients being treated with either cinacalcet or paricalcitol alone , matched for the same EPO treatment , which had been followed for 1 year , we have evaluated the effect of cinacalcet on anemia compared to that of paricalcitol . - pubmed
CONCLUSION : The combination of lower EPO dose in cinacalcet - treated patients compared with paricalcitol - treated patients , along with good SHPT control is a novel information and might have considerable benefits in dialysis patients not only preventing bone ( fractures ) and cardiovascular system ( calcifications ) damages but also in terms of cost savings via a reduction of EPO dosage . - pubmed
Exposure of 100ppm PTU significantly increased virus titers in the lungs of RSV - infected offspring compared with the control , and the 10ppm also elevated levels of interferon - gamma , a marker of pneumonia , in the bronchoalveolar lavage fluids of offspring . - pubmed
After univariate and multivariate analyses of the clinical variables , age , T classification , N classification , site of metastases , secondary metastases and disease - free interval ( DFI ) correlated with OS , whereas age , VCA - IgA titre , number of metastases and secondary metastases were related to LMS . - pubmed
We investigated the effects of angiotensin II ( ANG II)-dependent hypertension on the platelet proteome . - pubmed
METHODS AND RESULTS : Hypertension was induced in cyp1a1ren-2 transgenic rats by feeding indole-3 - carbinol ( n = 10 ) and in Fischer 344 rats by subcutaneously infusing ANG II ( n = 7 ) . - pubmed
Repeated blood withdrawals and stimulation of megakaryocytopoiesis by a thrombopoietin receptor agonist induced changes in the same protein spots but in the opposite direction to those induced by ANG II - dependent hypertension . - pubmed
CONCLUSION : ANG II - dependent hypertension is associated with enhanced protein degradation in platelets . - pubmed
Comparison of E - selectin and the other inflammatory markers in lumbar disc herniation : a new promising therapeutical window for radicular pain . - pubmed
OBJECTIVE : The aim of this study was to investigate the prevalence of inflammatory cells in lumbar disc herniations ( LDH ) and compare the prevalence of leukocyte adhesion protein " E - selectin " with other inflammatory cells such as T cells , B cells , and macrophages . - pubmed
SUMMARY OF BACKGROUND : Studies on inflammatory cells and biochemical mediators of inflammation have suggested that these factors may play an important role in pathophysiology of radicular pain , and the medical therapy was formed against to block these cells and inflammatory cytokines . - pubmed
METHODS : The herniated disc specimens obtained from 50 patients who had unilateral persistent radicular pain or unilateral radicular motor paresis were microscopically examined after staining with monoclonal antibodies of CD20 , CD45 , CD68 , and E - selectin . - pubmed
CONCLUSIONS : We suggest that E - selectin is as valuable as the other well - known inflammatory markers in the pathogenesis of LDH . - pubmed
In our opinion , beside the well - known nonsteroidal anti - inflammatory drugs , antagonists targeting E - selectin can be potentially effective therapeutics for controlling inflammation in LDH . - pubmed
( 2007 ) linked the circadian clock gene Bmal1 to hypertension and metabolic dysfunction in the SHR . - pubmed
Heart failure was associated with marked effects on the expression of Bmal1 , Clock and Rora in addition to several non - circadian genes important in regulating skeletal muscle phenotype including Mck , Ttn and Mef2c . - pubmed
We found that hypertensive / hypertrophic SHR showed a dampening of peak Bmal1 and Rev - erb expression in the liver , and the clock - controlled gene Pgc1alpha in the gastrocnemius . - pubmed
In addition , the core - clock gene Clock and the muscle - specific , clock - controlled gene Myod1 , no longer maintained a circadian pattern of expression in gastrocnemius from the hypertensive SHR . - pubmed
These findings provide a framework to suggest a mechanism whereby chronic heart failure leads to skeletal muscle pathologies ; prolonged dysregulation of the molecular clock in skeletal muscle results in altered Clock , Pgc1alpha and Myod1 expression which in turn leads to the mis - regulation of target genes important for mechanical and metabolic function of skeletal muscle . - pubmed
Immunohistochemical staining of the tumor was positive for EMA and CD34 , but negative for CEA , Ki67 , and GFAP . - pubmed
Immunohistochemical staining of proliferating vessels in the periphery of the tumor was positive for CD34 . - pubmed
Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy . - pubmed
BMP signaling is precisely regulated and perturbation of BMP signaling is connected to multiple diseases , including musculoskeletal diseases . - pubmed
In this review , we will summarize the recent progress in elucidation of BMP signal transduction , how overactive BMP signaling is involved in the pathogenesis of heterotopic ossification and Duchenne muscular dystrophy , and discuss possible therapeutic strategies for treatment of these diseases . - pubmed
RESULTS : At baseline , the PCOS patients and controls had similar body composition , lipids , insulin resistance and glucose metabolism parameters . - pubmed
Total and trunk fat percentages were negatively correlated with sex hormone binding globulin and were positively correlated with homeostatic model assessment of insulin resistance and free androgen index in the PCOS group .. After 6 months of treatment in the PCOS patients , total fat percentage increased from 24.5%+-7.1 % to 26.0%+-6.1 % ( p=.035 ) and trunk fat percentage increased from 20.2%+-8.9 % to 22.2%+-7.1 % ( p=.014 ) , although weight , BMI and waist to hip ratio ( WHR ) remained unchanged . - pubmed
Clinical impact of extended - spectrum beta - lactamase - producing Enterobacteriaceae in patients with biliary tract infection . - pubmed
BACKGROUND : Clinical outcomes associated with Gram - negative bacterial isolates with extended spectrum beta - lactamase ( ESBL ) in patients with biliary tract infection are largely unknown . - pubmed
[ Successful treatment of trastuzumab - resistant HER2 - positive breast cancer with extensive liver metastases using the combination of trastuzumab and capecitabine - a case report ] . - pubmed
We report a case of a trastuzumab - resistant human epidermal growth factor receptor-2(HER2)-positive breast cancer patient with extensive liver metastases and associated impaired liver function , who showed an excellent response to the combination of trastuzumab and capecitabine . - pubmed
Pigmented hepatocellular adenoma with complete CD34 immunostaining pattern : a diagnostic dilemma . - pubmed
We labeled the tumor as pigmented hepatic adenoma with complete CD34 staining pattern . - pubmed
Even though it is likely that there is no single source for all myofibroblasts , a common mechanism for the production of fibrosis is via the transforming growth factor - beta / phosphorylated Smad3 pathway . - pubmed
Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma . - pubmed
In fact , two histone deacetylase inhibitors ( HDIs ) , SAHA and Depsipeptide , are FDA approved for single - agent treatment of refractory cutaneous T cell lymphoma ( CTCL ) . - pubmed
These results suggest that selective inhibition of HDAC3 could be useful in treatment of CTCL by disrupting DNA replication of the rapidly cycling tumor cells , ultimately leading to cell death . - pubmed
METHODS : We investigated the relationship of baseline and on - treatment CRP with subsequent CV events in Cox models using a subset of white subjects with no history of CV disease from the UK ASCOT ( Anglo - Scandinavian Cardiac Outcomes Trial ) . - pubmed
We reported a patient whose bone marrow features resembled acute myeloid leukaemia with predominantly agranular blasts , devoid of Auer rods and expressing CD34 and HLA - DR on flow cytometry . - pubmed
METHODS : In total , 70 native liver biopsies of 44 biliary atresia patients were obtained at PE ( n=30 ) , 4.2 years after successful PE ( n=23 ) and 1.1 years after failed PE ( n=17 ) , and reviewed for cholestasis , fibrosis , inflammation , and cytokeratin 7 ( CK7 ) immunopositivity ( chronic cholestasis ) . - pubmed
Nevertheless , enhanced fibrosis [ Metavir stage 2 ( 1 - 4 ) vs. 4 ( 1 - 4 ) ] , bile duct proliferation [ grade 2 ( 1 - 2 ) vs. 1 ( 0 - 2 ) ] , and periportal CK7 immunostaining [ grade 1 ( 0 - 2 ) vs. 1 ( 0 - 4 ) ] persisted in 100 % , 87 % , and 61 % of subjects , respectively . - pubmed
Metavir fibrosis stage corresponded cirrhosis ( stage 4 ) in 52 % of the patients , associated with the presence of portal hypertension , and correlated with serum - conjugated bilirubin ( r=0.601 , P=0.002 ) , bile duct proliferation ( r=0.657 , P=0.001 ) , and CK7 positivity ( r=0.657 , P=0.001 ) . - pubmed
Aspartate transferase to platelet ratio index predicted native liver fibrosis and development of esophageal varices . - pubmed
CONCLUSIONS : Despite resolution of cholestasis and decreasing inflammation , bile duct proliferation , periportal CK7 immunostaining , and fibrosis persist after successful PE . - pubmed
Fibrosis is associated with biochemical cholestasis , bile duct proliferation , CK7 immunopositivity ( chronic cholestasis ) , and development of portal hypertension . - pubmed
Activated leukocyte cell adhesion molecule ( CD166 ): an " inert " cancer stem cell marker for non - small cell lung cancer ? - pubmed
Recently , the activated leukocyte cell adhesion molecule ( CD166 ) was identified as an " inert " cancer stem cell ( CSC ) marker for non - small cell lung cancer ( NSCLC ) . - pubmed
Few data exist regarding the clinical relevance of CD166 expression in NSCLC . - pubmed
We evaluated the expression of CD166 using immunohistochemistry in a large cohort of NSCLC patients ( n = 1,910 ) on a tissue microarray basis . - pubmed
Due to the results of this study , the theory of CD166 as a CSC marker for NSCLC must be questioned . - pubmed
The association of CD166 with smaller tumors and no nodal metastases does not make it a typical CSC marker . - pubmed
Further studies are required to investigate the functional role of CD166 in NSCLC . - pubmed
Multivariate regression demonstrated that significant variables for postoperative hip flexion were degree of preoperative flexion contracture , preoperative level of C - reactive protein , use of a 32 - mm femoral head , and postoperative heterotopic ossification . - pubmed
The HPV + head and neck cancer - specific gene set included various metabolism - related pathways , and the HPV - head and neck cancer - specific gene set included several pathways ; fibroblast , collagen degradation , actin - binding , and actin cytoskeleton . - pubmed
A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice . - pubmed
RESULTS : A common Rb1 allele derived from the BALB / cHeNhg strain was identified as the major determinant of radiation - induced OS risk at this locus . - pubmed
CONCLUSION : This is the first experimental demonstration of a functional and genetic link between reduced Rb1 expression from a common promoter variant and increased tumor risk after radiation exposure . - pubmed
Here , using optical molecular imaging , we demonstrate that the alarmin S100A8 / S100A9 serves as a sensitive local and systemic marker for the detection of even sub - clinical disease activity in inflammatory and immunological processes like irritative and allergic contact dermatitis . - pubmed
In a model of collagen - induced arthritis , we use S100A8 / S100A9 imaging to predict the development of disease activity . - pubmed
Furthermore , S100A8 / S100A9 can act as a very early and sensitive biomarker in experimental leishmaniasis for phagocyte activation linked to an effective Th1 - response . - pubmed
In conclusion , the alarmin S100A8 / S100A9 is a valuable and sensitive molecular target for novel imaging approaches to monitor clinically relevant inflammatory disorders on a molecular level . - pubmed
Over - expression of TLR4 - CD14 , pro - inflammatory cytokines , metabolic markers and NEFAs in obese non - diabetic Mexicans . - pubmed
The purpose of our study was to determine the levels of expression of TLR4 - CD14 , the pro - inflammatory cytokines , the metabolic markers and the NEFAs in a group of adult , non - diabetic obese Mexicans . - pubmed
RESULTS : Obesity is strongly associated with the expression of TLR4 ( 77 % , MFI ( Mean Fluorescence Index ) 7.70 ) and CD14 ( 86 % MFI 1.61 ) with 66 % double positives ( p = 0.000 ) . - pubmed
Insulin levels were 12.1 vs 19.7 mcU / ml ( p = 0.000 ) and the NEFAs were much higher in the obese vs normal weight / thin individuals ( p = 0.000 ) . - pubmed
A Novel KCNJ13 Nonsense Mutation and Loss of Kir7.1 Channel Function Causes Leber Congenital Amaurosis ( LCA16 ) . - pubmed
Mutations in the KCNJ13 gene that encodes the inwardly rectifying potassium channel Kir7.1 cause snowflake vitreoretinal degeneration ( SVD ) and leber congenital amaurosis ( LCA ) . - pubmed
Heterologous expressions of the mutant channel have suggested a dominant - negative loss of Kir7.1 function in SVD , but parallel studies in LCA16 have been lacking . - pubmed
Thus , we have extended the observation that Kir7.1 mutations are associated with vision disorders to include novel insights into the molecular mechanism of disease pathobiology in LCA16 . - pubmed
The European Neuroendocrine Tumor Society ( ENETS)/Tumor Node Metastasis ( TNM ) staging system together with a grading based on the Ki-67 proliferation index and mitotic counts has proven to give more appropriate prognostic information than the World Health Organization ( WHO)/American Joint Committee on Cancer ( AJCC ) TNM staging but may still fail to safely differentiate benign from malignant lesions . - pubmed
Well- or intermediately differentiated tumors & gt;=2 cm with imaging evidence of malignancy or with a Ki-67 & gt;2 % should be resected . - pubmed
It has been suggested that non - MEN related , nonfunctioning , and asymptomatic PNETs & lt;2 cm with a Ki-67 index & lt;=2 % carry a low risk of metastasis and may be observed in the absence of clinical or radiologic criteria of malignancy or progression , especially in older patients . - pubmed
We identify RPTPsigma , a transmembrane tyrosine phosphatase , as a therapeutic target for FLS - directed therapy . - pubmed
Furthermore , administration of the RPTPsigma decoy protein ameliorated in vivo human FLS invasiveness and arthritis severity in the K / BxN serum transfer model of RA . - pubmed
Differential Levels of Alpha-2 - Macroglobulin , Haptoglobin and Sero - Transferrin as Adjunct Markers for TB Diagnosis and Disease Progression in the Malnourished Tribal Population of Melghat , India . - pubmed
Three most differentially expressed proteins ; alpha-2 - macroglobulin ( A-2 - M ) , sero - transferrin and haptoglobin were identified by MALDI - TOF MS analysis , which were up - regulated in the malnourished patients with active TB and down - regulated in the malnourished patients compared with the healthy controls . - pubmed
Our preliminary results suggest that A-2 - M , sero - transferrin and haptoglobin may be clinically relevant host biomarkers for TB diagnosis and disease progression in the malnourished population . - pubmed
Akt Kinase - Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma . - pubmed
Aki1 has been suggested as a therapeutic target , but its potential has yet to be evaluated in a tumor setting . - pubmed
Clinically , Aki1 was expressed in most human DMM specimens where its expression correlated with phosphorylated CREB1 . - pubmed
Notably , Aki1 siRNA potently blocked tumor growth in an orthotopic implantation model of DMM when administered directly into the pleural cavity of tumor - bearing mice . - pubmed
Our findings suggest an important role for the Aki1 - CREB axis in DMM pathogenesis and provide a preclinical rationale to target Aki1 by intrathoracic therapy in locally advanced tumors . - pubmed
Quantitative hepatitis B surface antigen combined with hepatitis B e antigen as sustained virological response predictors during extended therapy with Peginterferon alfa-2a for hepatitis B e antigen - positive chronic hepatitis B. - pubmed
BACKGROUND : The best strategy for chronic hepatitis B patients with poor response to 48 weeks of Peginterferon - based therapy has been controversial and the predictive value of hepatitis B surface antigen ( HBsAg ) , hepatitis B e antigen ( HBeAg ) and hepatitis B virus ( HBV ) DNA levels for determining the sustained virological response ( SVR ) of these patients is uncertain . - pubmed
AIMS : In this study , we investigated the effects of Bax - inhibiting peptide ( Bip)-V5 , an anti - apoptosis membrane - permeable peptide , on the 6 - hydroxydopamine ( 6 - OHDA ) induced Parkinson ' s disease ( PD ) model rats . - pubmed
SIGNIFICANCE : Our results provide a new idea that Bax - inhibiting peptide may be a promising preventive or therapeutic method for PD . - pubmed
The hormone islet amyloid polypeptide ( IAPP , or amylin ) plays a role in glucose homeostasis but aggregates to form islet amyloid in type-2 diabetes . - pubmed
Recent work suggests a role for IAPP aggregation in cardiovascular complications of type-2 diabetes and hints at a possible role in type-1 diabetes . - pubmed
Open questions in the field include the relative importance of the various mechanisms of beta - cell death , the relevance of reductionist biophysical studies to the situation in vivo , the molecular mechanism of amyloid formation in vitro and in vivo , the factors which trigger amyloid formation in type-2 diabetes , the potential role of IAPP in type-1 diabetes , the development of clinically relevant inhibitors of islet amyloidosis toxicity , and the design of soluble , bioactive variants of IAPP for use as adjuncts to insulin therapy . - pubmed
Enhanced radiosensitivity by DNMT3B RNAi was also observed in a tumor xenograft model . - pubmed
Downregulation of DNMT3B , one of the targets identified using this method , radiosensitizes cancer cells by disturbing multiple DNA damage responses . - pubmed
Mutation and CNV frequencies offer insights into which genes may play tumor suppressive or oncogenic roles , such as NEIL2 and RRM2B , respectively . - pubmed
PARP-1 inhibition alleviates diabetic cardiac complications in experimental animals . - pubmed
We investigated the implication of PARP-1 in diabetic cardiac complications . - pubmed
PARP inhibitor 4 - aminobenzamide ( 4 - AB ) was administered daily for ten weeks after diabetes induction . - pubmed
Hearts isolated from diabetic animals showed increased PARP-1 enzyme activity compared to control animals while significantly reduced by 4 - AB administration . - pubmed
PARP-1 inhibition by 4 - AB alleviated cardiac ischemia in diabetic animals as indicated by ECG changes . - pubmed
PARP-1 inhibition also reduced cardiac inflammation in diabetic animals as evidenced by histopathological changes . - pubmed
Moreover , PARP-1 inhibition decreased serum levels of TNF - alpha and cardiac nitrite but increased cardiac GSH contents in diabetic animals . - pubmed
However , PARP-1 inhibition did not significantly affect the developed hyperglycemia . - pubmed
Our findings prove that PARP-1 enzyme plays an important role in diabetic cardiac complications through combining inflammation , oxidative stress , and fibrosis mechanisms . - pubmed
Mo polyoxometalate nanoparticles inhibit tumor growth and vascular endothelial growth factor induced angiogenesis . - pubmed
After a single muscle injury , C / EBPbeta - deficient satellite cells fail to self - renew resulting in a reduction of satellite cells available for future rounds of regeneration . - pubmed
LTB - Syn : a recombinant immunogen for the development of plant - made vaccines against synucleinopathies . - pubmed
Synucleinopathies are neurodegenerative diseases characterized by the abnormal accumulation of alpha - synuclein ( alpha - Syn , a 140 amino acid protein that normally plays various neurophysiologic roles ) aggregates . - pubmed
Parkinson ' s disease ( PD ) is the synucleinopathy with the highest epidemiologic impact and although its etiology remains unknown , alpha - Syn aggregation during disease progression pointed out alpha - Syn as target in the development of immunotherapies . - pubmed
Our results suggest that dietary soy ameliorates adiposity , insulin sensitivity , adipose tissue inflammation , and arterial stiffness and exerts a beneficial shift in gut microbial communities in a rat model that mimics human menopause . - pubmed
Taken together , our results indicated that SAA suppressed c - met expression and enhanced the sensitivity of lung adenocarcinoma A549 cells to cisplatin through AKT / mTOR signaling pathway . - pubmed
RESULTS : Serum Se and SELENOP concentrations were relatively low in both control and AITD women . - pubmed
From first to third trimester , TPO - aAb and TG - aAb declined in AITD by 71 % and 60 % , respectively . - pubmed
T cell trafficking into tumors depends on a " match " between chemokine receptors on effector cells ( e.g. - pubmed
There is often a chemokine / chemokine receptor " mismatch " , with tumors producing minute amounts of chemokines , resulting in inefficient targeting of effectors to tumors . - pubmed
We aimed to alter tumors to produce higher levels of CXCL11 , a CXCR3 ligand , to attract more effector cells following immunotherapy . - pubmed
In our first approach , we used modified chimeric antigen receptor ( CAR )- transduced human T cells to deliver CXCL11 ( CAR / CXCL11 ) into tumors . - pubmed
CAR / CXCL11 and VV.CXCL11 significantly increased CXCL11 protein levels within tumors . - pubmed
Both approaches were successful in increasing CXCL11 levels within the tumors ; however , only the vaccinia approach was successful in recruiting T cells and augmenting anti - tumor efficacy . - pubmed
Tempol , a superoxide dismutase mimetic agent , reduces cisplatin - induced nephrotoxicity in rats . - pubmed
This study is aimed to evaluate the role of a super oxide dismutase ( SOD ) mimetic agent , tempol , in protection against CP nephrotoxicity in rats . - pubmed
Tempol also significantly decreased kidney caspase-3 expression which was elevated by CP toxicity . - pubmed
[ Indoleamine 2,3 - Dioxygenase Activity during Long - Term Letrozole Therapy for Hormone Receptor - Positive Breast Cancer ] . - pubmed
Endocrine therapy is effective for elderly patients who are diagnosed with estrogen receptor - positive breast cancer and can not receive surgical treatment or chemotherapy because of advanced age . - pubmed
Based on previous research , individuals who had lower income , lower educational levels , or type 2 diabetes ; who were African American or Hispanic , uninsured , or not using insulin or oral medication for diabetes ; or who did not have DR were defined as being at high risk of missing recommended eye examinations . - pubmed
[ Correlation of EBV Infection with Expression of TNF - alpha - Inducing Protein 3 Gene and A20 Protein in Hodgkin 's Lmphoma ] . - pubmed
OBJECTIVE : To analyze the correlation of EBV infection with expression of TNF - alpha - inducing protein 3 gene and A20 protein in Hodgkin lmphoma . - pubmed
Correlation analysis showed that EBV infection did not significantly relate with expression loss of A20 protein and the gene deletion of TNF - alpha inducing protein 3 ( P>0.05 ) . - pubmed
CONCLUSION : The expression loss of A20 protein and gene detection of TNFalpha inducing protein 3 are found in both EBV negative and positive patients with Hodgkin ' s lymphoma , however the results of immunohistochemical staining and fluorescence in situ hybridization are not complete consistant , the reason may closely relate with the technical factors . - pubmed
Identification and Characterization of Known Biallelic Mutations in the IFT27 ( BBS19 ) Gene in a Novel Family With Bardet - Biedl Syndrome . - pubmed
We report a family with typical BBS features ( retinitis pigmentosa , postaxial polydactyly , obesity , cognitive impairment , and atrioventricular septal defect ) mutated in IFT27 / BBS19 . - pubmed
This is the third report of IFT27 mutations in BBS patients confirming IFT27 as a BBS gene ( BBS19 ) . - pubmed
Mutations in IFT genes ( IFT27 , IFT172 and IFT74 ) confirm the IFT - pathway as a pathomechanism for BBS . - pubmed
Obtained data clarify peripheral effects that occur during activation of the I1Rs under endogenous catecholaminergic stress , and can be used in clinical practice for more precise control of heart contractility in some cardiovascular pathologies . - pubmed
Cytomegalovirus ( CMV ) has emerged as an immunologic target in GBM given that tumor cells have been shown to express the CMV - associated proteins IE1 and pp65 . - pubmed
As the patient 's tumor stained positive for CMV antigens IE1 and pp65 , it is hypothesized that she developed an immune response against CMV during recovery that contributed to anti - tumor surveillance and prolonged survival . - pubmed
Avagacestat , a gamma ( gamma )- secretase inhibitor that was in development for treatment of Alzheimer ' s disease , produced ovarian granulosa - thecal cell tumors in rats and dogs and a glomerulopathy with profound proteinuria in female rats . - pubmed
Ovarian proliferative changes in rats likely resulted from : 1 ) inhibition of Notch signaling pathways regulating ovarian follicular differentiation / development , characterized microscopically as altered ovarian cyclicity and/or ovarian follicular degeneration ; 2 ) subsequent disruption of the hypothalamic - pituitary - ovarian axis due to ovarian atrophy with decreases in serum estrogen and progesterone ( as low as 0.45x and 0.21x controls , respectively ) ; and 3 ) chronic gonadotropin stimulation and pituitary hypertrophy / hyperplasia in response to the absence of negative feedback . - pubmed
In contrast , adrenocortical hypertrophy in female rats was considered secondary to ovarian changes based on the absence of this finding in avagacestat - treated OVX rats and no increase in ACTH staining in the pituitary . - pubmed
In addition , the expression of prostaglandin E2 receptor 4 ( EP4 ) was decreased in cardiac fibrosis . - pubmed
In vivo lnc000908 silencing by lentivirus increased the EP4 level , decreased endothelial - mesenchymal transition ( EndMT ) and improved cardiac fibrosis and cardiac function . - pubmed
This study demonstrates that lnc000908 is a novel regulator of cardiac fibrosis by modulating the EP4 expression and EndMT . - pubmed
Mutation of CEP72 Gene May Predispose Patients to Hepatotoxicity . - pubmed
Polymorphisms in CEP72 have been linked to increased incidence of vincristine - induced toxicities , namely peripheral neuropathy . - pubmed
This report describes hepatotoxicity that first developed during consolidation in a patient homozygous for the CEP72 risk alleles . - pubmed
RESULTS : Results indicate that C3948 cell line has a histological phenotype representative of original ATC cells and a completely aberrant karyotype with many chromosomal losses and gains ; harbors mutated TP53 , STK11 , and DIS3L2 genes ; presents a gene expression profile similar to C643 ATC commercial cell line , but with some unique alterations ; has a doubling time similar to C643 ; and the IC50 profile for paclitaxel , doxorubicin , and cisplatin is similar to C643 , although higher for cisplatin . - pubmed
After radiolabeling the immunoconjugates with zirconium-89 , we conducted PET imaging and biodistribution studies in two different mouse models of HER2 - expressing breast cancer . - pubmed
ImmunoPET and biodistribution experiments in athymic nude mice bearing HER2 - expressing BT474 human breast cancer xenografts yielded no significant differences in the in vivo behavior of the radioimmunoconjugates . - pubmed
Yet experiments in tumor - bearing humanized NSG mice revealed that 89Zr - DFO - sspertuzumab - EndoS produces higher activity concentrations in the tumor ( 111.8 + - 39.9 % ID / g ) and lower activity concentrations in the liver and spleen ( 4.7 + - 0.8 % ID / g and 13.1 + - 4.0 % ID / g , respectively ) than its non - site - specifically labeled cousin , a phenomenon we believe stems from the altered binding of the former to huFcgammaRI . - pubmed
Genome - wide identification of antimicrobial peptide genes ( AMPs ) and their expression in response to fungal infection was performed in the resistant cassava cultivar ( Huay Bong 60 ; HB60 ) in comparison with the highly susceptible cultivar ( Hanatee ; HN ) . - pubmed
Altogether , these findings suggest that snakins have a potential function in the CAD defense response in cassava . - pubmed
Suppression of sirtuin 1 alleviates airway inflammation through mTOR - mediated autophagy . - pubmed
Sirtuin 1 ( SIRT1 ) is involved in the pathogenesis of allergic asthma . - pubmed
This study aimed to investigate whether EX-527 , a specific SIRT1 inhibitor , exerted suppressive effects on allergic airway inflammation in mice submitted to ovalbumin ( OVA ) inhalation . - pubmed
The study found that EX-527 reversed OVA - induced airway inflammation , and reduced OVA - induced increases in inflammatory cytokine expression , and total cell and eosinophil counts in bronchoalveolar lavage fluid . - pubmed
To assess whether EX-527 inhibited airway inflammation in asthma through the mTOR - mediated autophagy pathway , rapamycin was administered to mice treated with EX-527 after OVA sensitization . - pubmed
Taken together , the present findings indicated that EX-527 may inhibit allergic airway inflammation by suppressing autophagy , an effect mediated by mTOR activation in allergic mice . - pubmed
We focused on eight draggable genes for BTC , which were described as having evidence of therapeutic impact ( evidence level 2A-3B ) based on the clinical practice guidance for next - generation sequencing in cancer diagnosis and treatment ; these include ERBB2 , NTRK1 , RNF43 , CDK6 , CDKN2B , FGFR2 , IDH1 , and IDH2 . - pubmed
Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy : Implications for Early Diagnosis and Translational Research in Alzheimer ' s Disease . - pubmed
RESULTS : Neutrophil , platelet , and monocyte counts , as well as NLR , PLR , and MLR values were higher in the manic episodes of bipolar disorder compared to the control group . - pubmed
Decreased neutrophil and lymphocyte counts , and decreased NLR , PLR , and MLR were observed in the remission period after - treatment of the manic bipolar disorder episodes . - pubmed
CONCLUSIONS : The study indicates that NLR and PLR may be used as state markers and that MLR may be used as a trait marker in bipolar disorder . - pubmed
Aberrant NSUN2 - mediated m5C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma . - pubmed
Studies have shown that the expression of H19 lncRNA is abnormally elevated and has a carcinogenic effect in many types of tumors . - pubmed
Besides , both the m5C methylation level and the expression level of H19 lncRNA in hepatocellular carcinoma tissues were significantly higher than those in adjacent non - cancer tissues , which were closely associated with poor differentiation of hepatocellular carcinoma ( HCC ) . - pubmed
The m5C - modified H19 lncRNA may promote the occurrence and development of tumors by recruiting the G3BP1 oncoprotein . - pubmed
Inhibiting the Pkm2 / b - catenin axis drives in vivo replication of adult cardiomyocytes following experimental MI . - pubmed
While expression of muscle pyruvate kinase 2 ( Pkm2 ) , a cytosolic enzyme catalyzing the final step in glycolysis , is high in end - stage heart failure ( HF ) , the loss of Pkm2 promotes proliferation in some cellular systems , in vivo . - pubmed
Thus , we investigated the potential for Pkm2 to regulate CM proliferation in a mouse model of myocardial infarction ( MI ) employing inducible , cardiac - specific Pkm2 gene knockout ( Pkm2KOi ) mice . - pubmed
We found a lack of cardiac hypertrophy or expression of the fetal gene program in Pkm2KOi mice post MI , as compared to vehicle control animals ( P < 0.01 ) , correlating with smaller infarct size , improved mitochondrial ( mt ) function , enhanced angiogenesis , reduced degree of CM apoptosis , and reduced oxidative stress post MI . - pubmed
Collectively , this work supports a novel antiproliferative function for Pkm2 in CM through the sequestration of Ctnnb1 in the cytoplasm of CM whereas loss of Pkm2 is essential for CM proliferation . - pubmed
Reducing cardiac Pkm2 expression may provide a useful strategy for cardiac repair after MI in patients . - pubmed
Impact of hypoxia and AMPK on CFTR - mediated bicarbonate secretion in human cholangiocyte organoids . - pubmed
BACKGROUND AND AIMS : Cholangiocytes express cystic fibrosis transmembrane conductance regulator ( CFTR ) which is involved in bicarbonate secretion for the protection against bile toxicity . - pubmed
Hypoxia is known to diminish CFTR activity in the intestine , but whether it effects CFTR activity in cholangiocytes remains unknown . - pubmed
Thus , the aim of this study is to investigate the effect of hypoxia on CFTR activity in intrahepatic cholangiocyte organoids ( ICOs ) and test drug - interventions to restore bicarbonate secretion . - pubmed
During hypoxia , CFTR activity significantly decreased ( p=0.01 ) . - pubmed
Switching from oxygen to hypoxia during CFTR - measurements , reduced CFTR activity ( p=0.03 ) . - pubmed
Importantly , addition of AMPK - inhibitor restored CFTR - mediated anion - secretion during hypoxia . - pubmed
Response of plasma insulin to small doses of tolbutamide in obesity and acromegaly . - pubmed
The early response of plasma insulin ( IRI ) to successive intravenous doses of 50 , 100 and 200 mg of tolbutamide was studied in nondiabetic obese subjects , in acromegalic patients , and in healthy controls . - pubmed
The insulin response was correlated with the basal IRI in controls and in obese subjects but not in acromegalic patients . - pubmed
The results suggest that in obesity the stimulus - secretion coupling of insulin output is normal but the number of secretory units is increased . - pubmed
In acromegaly the insulin release pattern is compatible with an increased number of secretory units which , however , are relatively insensitive to tolbutamide , probably due to an elevated serum growth hormone level . - pubmed
[ Juvenile optic neuropathy caused by Km variants of biotinidase ] . - pubmed
Bone abnormalities included abnormal cartilage - bone transition at the growth plate , general bone matrix disorganization due to irregularly oriented bundles of collagen , mineral crystals on the osteocyte lacunar rim , and accumulations of thickened collagen fibrils , also along the osteocyte lacunar rim . - pubmed
The most likely explanation is that a factor , or factors , cause the inhibition of release of lymphokines which thereby have a suppressive effect on rheumatoid inflammation . - pubmed
Injury induces increase of von Willebrand factor in rat endothelial cells . - pubmed
Endothelial cells from normal , endotoxin - treated , and balloon - injured rats were stained with vWF antibodies and visualized using a biotinylated secondary antibody and avidin - tagged peroxidase . - pubmed
Endotoxin treatment and balloon injury caused a threefold increase in intracellular vWF , and immunoelectron microscopy showed the endoplasmic reticulum to stain heavily by the vWF antibody . - pubmed
These results suggest that endothelial injury leads to an increased intracellular content of vWF that is localized primarily in the endoplasmic reticulum . - pubmed
Univariate analysis showed that female sex , normal performance status , well - differentiated tumor , and curative resection were associated with increased survival ; cholangiocarcinoma , nodal metastases , cirrhosis , hypocalcemia , prolonged prothrombin time , and increased serum transaminase and alkaline phosphatase were associated with decreased survival . - pubmed
Cox multivariate analysis showed that curative resection , normal performance status , and well - differentiated tumors were associated with increased survival , and prolonged prothrombin time and hypocalcemia were associated with decreased survival . - pubmed
[ Hormone receptor determination in breast cancer using the dextran- coated charcoal method and monoclonal antibodies : correlation with cytomorphologic grading ] . - pubmed
In 129 cases , results from ER - ICA ( Estrogen receptor immunocytochemical assay ) applied to breast carcinoma biopsy smears and results from ER - EIA ( Estrogen receptor enzyme immunoassay ) applied to cytosols of breast carcinoma were compared to the results of ER(DCC ) , PR(DCC ) and a cytomorphological grading . - pubmed
There is a relation between the visual nuclear grade from the Pappenheim stained specimens and ER - ICA and ER - EIA . - pubmed
Our present data show clearly that there is a closer correlation of cytomorphology with ER - EIA than with ER(DCC ) and PR(DCC ) . - pubmed
Cell lines derived from some thymic lymphomas presented a very immature phenotype and did not express cellular markers of either T - cells ( Thy 1.2 , Lyt 1.2 , and Lyt 2.2 ) or B - cells ( cytoplasmic IgM ) even after treatment with several differentiation inducers . - pubmed
Safer proteinase treatment of sciatica . - pubmed
Induction of specific immunity to human colon carcinoma by anti - idiotypic antibodies to monoclonal antibody CO17 - 1A. - pubmed
Anti - idiotypic antibodies ( Ab2 ) to murine monoclonal antibody ( mAb ) CO17 - 1A ( Ab1 ) , which defines an antigen associated with human colon carcinoma , were produced in goats . - pubmed
The Ab2 inhibited binding of Ab1 to colon carcinoma cells , and purified tumor antigen inhibited binding of Ab1 to Ab2 . - pubmed
Moreover , both Ab1 and Ab3 bound to the isolated tumor antigen , and the Ab3 lysed human colon carcinoma cells in culture in the presence of rabbit complement . - pubmed
Thus , Ab2 raised to mAb CO17 - 1A are candidates for use in immunotherapy trials in cancer patients . - pubmed
Expression of Ca antigen on human urinary bladder tumors . - pubmed
Flow cytometric measurements of Ca antigen ( Ca ) visualized by immunofluorescence with Ca1 monoclonal antibody ( Ca1 ) were performed on cells from 26 urinary bladder carcinomas of various histologic grades and DNA ploidy and on 6 samples of morphologically normal urothelium . - pubmed
Urinary kallikrein activity , renal hemodynamics , and electrolyte handling during chronic beta blockade with propranolol in hypertension . - pubmed
Diurnal patterns of serum immunoreactive calcitonin in healthy males and in insulin dependent diabetics . - pubmed
Serum immunoreactive calcitonin ( iCT ) was measured half - hourly for 27 h in five healthy males and four insulin dependent juvenile diabetic males during normal activity . - pubmed
Anti - TFB immunity was studied in the recipients either by looking for the apparition of cutaneous lesions after superinfection by TFB , or by counting of Listeria monocytogenes remaining in the liver and in the spleen 48 h after a mixture of TFB and L. - pubmed
These tests are based on acute dosing of mice and various blood or serum measurements : ( a ) total white blood cell count for leukopenia ; ( b ) BUN for kidney toxicity ; ( c ) SGPT for liver toxicity ; and ( d ) creatine phosphokinase MB isozyme ( CPK - MB ) for cardiotoxicity . - pubmed
The factor VIII gene has been cloned in 1984 and a large number of mutations that cause hemophilia A have been identified in the last decade . - pubmed
The most common of the mutations is an inversion of factor VIII that accounts for nearly 45 % of patients with severe hemophilia A. - pubmed
MDM2 and CDK4 gene amplification in Ewing ' s sarcoma . - pubmed
Amplification of the MDM2 gene , which maps to chromosome band 12q13 and encodes a p53 - binding protein , may result in functional inactivation of p53 and has been observed in various bone and soft tissue sarcomas . - pubmed
Published studies have included few cases of Ewing ' s sarcoma ( ES ) or peripheral neuroectodermal tumour ( PNET ) , a tumour group in which alterations of the p53 pathway have so far not been extensively studied . - pubmed
We examined two ES cell lines , RD - ES and SK - ES-1 , and 30 specimens from 27 patients ( 24 ES , 6 PNET ; 19 primary , 4 local recurrence , 7 metastasis ) for MDM2 gene amplification by Southern blot analysis . - pubmed
All 30 clinical specimens had been confirmed to contain sufficient ES / PNET DNA by the demonstration of a rearrangement of the t(11;22)-associated EWS gene using an EWS cDNA probe on the same blots . - pubmed
MDM2 gene amplification was detected in 3 of 30 specimens ( 10 per cent ) , including two ES and one PNET , but in neither of the cell lines . - pubmed
Insulin secretion in obese and non - obese women with polycystic ovary syndrome and its relationship with hyperandrogenism . - pubmed
Glucose , insulin , androstenedione and testosterone levels were determined and the blood glucose and insulin response of women with PCO and normal women were compared . - pubmed
Affinity selection of a 15 - mer random peptide library displayed on bacteriophage M13 has been used to identify potent ligands for the human urokinase receptor , a key mediator of tumor cell invasion . - pubmed
Interleukin-6 , neutrophilia and the acute phase protein response in colorectal cancer patients . - pubmed
White blood cell counts and circulating interleukin-6 concentrations were measured in male colorectal cancer patients with ( n = 12 ) and without ( n = 15 ) evidence of an acute phase protein response . - pubmed
These results suggest that in colorectal cancer patients although an acute phase protein response is associated with neutrophilia , both events can occur independent of circulating interleukin-6 concentrations . - pubmed
Expression of histamine receptors in different cell lines derived from mammary gland and human breast carcinomas . - pubmed
Epidermal growth factor receptor immunoreactivity in gallbladder and extrahepatic biliary tract tumours . - pubmed
Elevated levels of epidermal growth factor receptor ( EGFR ) , a transmembrane protein tyrosine kinase receptor , are found in carcinomas from various sites of the body . - pubmed
We investigated the expression of EGFR in carcinoma of the gallbladder ( n = 13 ) , common bile duct ( n = 7 ) and ampulla of Vater ( n = 9 ) . - pubmed
In conclusion , EGFR expression is increased in both gallbladder , common bile duct and ampullary carcinomas but not in non - malignant conditions of the gallbladder and biliary tract . - pubmed
These findings suggest that EGFR overexpression occurs late in the sequential development of gallbladder and biliary tract cancers . - pubmed
Serum levels of squamous cell carcinoma antigen and carcinoembryonic antigen as tumor markers of vulvar cancer . - pubmed
OBJECTIVE : To assess whether squamous cell carcinoma ( SCC ) antigen and carcinoembryonic antigen ( CEA ) are useful as tumor markers of vulvar cancer . - pubmed
METHODS : The serum levels of SCC antigen and CEA were determined for 30 patients with invasive vulvar carcinoma . - pubmed
Human gastric lipase ( HGL ; triacylglycerol lipase ; EC 3.1.1.3 ) plays an important role in the digestion of dietary triglycerides in the gastrointestinal tract , especially in patients suffering from pancreatic lipase deficiencies . - pubmed
The HGL and RLL gene organizations are identical , suggesting that RLL is the rat gastric lipase expressed in the serous von Ebner glands of the tongue . - pubmed
The neurotrophic factors ciliary neurotrophic factor and brain - derived neurotrophic factor can prevent motor neuron cell death during development and after nerve lesion in neonatal rodents . - pubmed
This way of delivery corresponds to the physiological situation in adult rodents , under which endogenous CNTF is present in the cytosol of Schwann cells and BDNF expression is upregulated after nerve lesion , making these factors available to the damaged motor neurons . - pubmed
Recent results show that overexpression of muscle - derived neurotrophin-3 prevents degeneration of axons and motor endplates , but has only little effect on the number of motor neuron cell bodies in a murine animal model of motor neuron disease . - pubmed
We now hypothesize that these factors also regulate PMN surface integrins , that regulation of UC PMNs is different than that of control PMNs , and that the integrin regulation is consistent with the ROS regulation . - pubmed
In contrast , rectal dialysates failed to up - regulate CD11b of inactive UC PMNs and in fact down - regulated CD11b . - pubmed
Transforming growth factor - beta stimulates urokinase expression in tumor - associated macrophages of the breast . - pubmed
Recent studies have shown that urokinase ( uPA ) is an independent prognostic marker in breast cancer . - pubmed
uPA plays a key role in the degradation of tumor matrix and promotes tumor progression . - pubmed
Our objective in the present study was to provide evidence that tumor growth factor - beta ( TGF - beta ) released from breast cancer cells markedly up - regulates uPA expression in tumor - associated macrophages ( TAMs ) . - pubmed
We reported previously that B16,JB / RH and JB / MS melanomas of C57BL/6 mice express the common melanoma - associated antigen ( MAA ) recognized by MM2 - 9B6 monoclonal antibody ( MAb ) . - pubmed
Southern blot analysis of EcoRI- and HindIII - digested DNAs from these melanomas showed several retroviral insertion sites . - pubmed
Our data indicate that c - maf is a common insertion site of MelARV in BL6 , Meli - A1 and Meli - BL melanomas , whereas no such insertion site was found in the melanocytes infected with MelARV but not malignantly transformed . - pubmed
Recently , leukocytapheresis and massive immunoglobulin 7S treatment are available for the treatment of ulcerative colitis . - pubmed
HTLV-1 - infected subjects also had poor interleukin ( IL )- 4 responses to mitogenic stimulation , unlike persons without HTLV-1 infection . - pubmed
The impaired IgE responses and other effects of IL-4 down - regulation may be contributing factors to more severe disease and impaired response to treatment of strongyloidiasis in some HTLV-1 - infected persons . - pubmed
Growth factors , especially interleukin-6 , appear to be critical for disease progression , and interruption of autocrine and paracrine loops has been achieved with resultant inhibition of myeloma cell growth . - pubmed
A potential role for B / macrophage cells in inflammation was shown by their ability to express prostaglandin H synthase-1 ( COX-1 ) and prostaglandin H synthase-2 ( COX-2 ) and by their production of prostaglandin ( PG ) E ( 2 ) . - pubmed
In contrast , COX-2 and the prostanoids PGE ( 2 ) , PGF ( 2alpha ) and PGD ( 2 ) are highly inducible in B/ macrophage cells upon stimulation with lipopolysaccharide , CD40 ligand , or via engagement of surface IgM , supporting a role for these cells in inflammation . - pubmed
Human activin - A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells . - pubmed
In this study , we investigated the role of activin in the initiation and progression of human atherosclerosis . - pubmed
We developed an " in situ free - activin binding assay " by using biotinylated follistatin , which allowed us to detect bioactive activin at specific sites in atherosclerotic lesions . - pubmed
The mRNAs encoding the activin receptors are expressed similarly in normal and atherosclerotic tissue , which indicates that activin - A signaling in atherogenesis is most likely dependent on changes in growth factor concentrations rather than on receptor levels . - pubmed
Endocrine studies in cases 1 - 4 and 6 showed that cases 1 , 3 , and 6 had definite primary hypogonadism , with basal FSH levels of 54 , 39 , and 41 IU / L , respectively , whereas case 2 with severe malnutrition was unremarkable for the baseline values , and case 4 had fairly good testicular function . - pubmed
Sequence analysis in cases 1 - 4 and 6 showed that they had normal sequences of each exon of DMRT1 and the DM domain of DMRT2 on the normal chromosome 9 , and that cases 1 - 4 had normal SRY sequence . - pubmed
The glomerular filtration rate , urinary zinc excretion , zinc clearance , zinc clearance / creatinine clearance ratio , zinc tubular reabsorption , glycosuria , plasma glucose , C - peptide , glucagon , and cortisol were investigated in 10 normal individuals ( Group C1 and Group C2 , respectively ) and 10 IDDM patients ( Group E1 : hyperglycemic and glycosuric and Group E2 : normoglycemic and aglycosuric ) during placebo or venous zinc tolerance test . - pubmed
Results revealed that 8.1 AH is associated with a high in vivo and in vitro production of TNF - alpha , which in turn seems responsible for increased serum levels of sELAM-1 , cortisol , and IL-10 . - pubmed
In conclusion , the increased spontaneous release of TNF - alpha , which modifies a certain number of immunologic parameters , may be the most characterizing feature of 8.1 AH . - pubmed
Tax , the human T cell leukemia virus type I oncoprotein , plays a crucial role in viral transformation and the development of the virally associated disease adult T cell leukemia . - pubmed
Tax - associated acceleration of cell cycle progression may play a role in the ability of this viral oncoprotein to mediate cellular transformation and promote the development of human T cell leukemia virus type I - associated diseases . - pubmed
Mutations in the genes of hematopoietic growth factor receptors as a cause of congenital cytopenia , such as congenital amegakaryocytic thrombocytopenia ( CAMT ) or severe congenital neutropenia ( CN ) , are discussed . - pubmed
In patients with CAMT , we found inherited mutations in c - mpl , the gene coding for the thrombopoietin receptor , in 8 out of 8 cases . - pubmed
Functional studies demonstrated defective thrombopoietin ( TPO ) reactivity in hematopoietic progenitor cells and platelets in CAMT patients . - pubmed
CAMT is caused by inherited mutations in c - mpl , the gene for the thrombopoietin receptor , which lead to reduced or absent reactivity to TPO . - pubmed
In contrast , mutations in the G - CSF receptor in CN are acquired and are most probably connected with progression of the neutropenia into MDS / leukemia as a result of a loss of differentiation signaling . - pubmed
A naturally occurring mutation ( A1924 T ) in the IQ domain altered hH1 function in a manner characteristic of the Brugada arrhythmia syndrome , but at the same time inhibited slow inactivation induced by Ca2 +/CaM , yielding a clinically benign ( arrhythmia free ) phenotype . - pubmed
The objective of this study was to evaluate regeneration of alveolar bone and cementum , and associated root resorption and ankylosis following surgical implantation of rhBMP-2 / ACS in a canine clinical model . - pubmed
rhBMP-2 / ACS did not appear to be associated with aberrant healing events such as root resorption and ankylosis under these simulated clinical conditions . - pubmed
CONCLUSIONS : Surgical implantation of rhBMP-2 / ACS may be used safely to support regeneration of alveolar bone in intrabony periodontal defects in dogs without aberrant events such as root resorption or ankylosis complicating the regenerative procedure . - pubmed
A 51 - year - old Japanese man diagnosed with CML was treated with interferon - alpha . - pubmed
This case suggests that interferon - alpha plus cytarabine ocfosfate therapy may be of benefit in the treatment of extramedullary blast crisis of CML . - pubmed
Patient 's age , sex , renal diagnosis , diabetes mellitus , time on dialysis , dialysis adequacy , erythropoietin dose , hepatitis C or body weight did not affect response rates . - pubmed
The value of low dose ( 1 microg ) ACTH stimulation test in the investigation of non - classic adrenal hyperplasia due to 11beta - hydroxylase deficiency . - pubmed
Our aim was to investigate the responses of 11 - deoxycortisol to 1microg ACTH ( LDT ) test in women with NCAH due to 11 - beta hydroxylase ( 11 - beta OH ) deficiency and to compare them with the values obtained after SDT in the patients and in the control subjects . - pubmed
RESULTS : Peak hyperleptinemia occurred after 16 hours of HC infusion ; peak / baseline leptin levels were 129 % ( placebo ) , 140 % ( 30 mg of HC for 24 hours , p = 0.05 ) , and 185 % ( 100 mg of HC for 24 hours , p & lt ; 0.01 ) . - pubmed
The Eleven Lysine - rich Leukemia ( ELL ) gene undergoes translocation and fuses in frame to the Multiple Lineage Leukemia ( MLL ) gene in a substantial proportion of patients suffering from acute forms of leukemia . - pubmed
Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease . - pubmed
Recently , we reported that elevated levels of IL-8 , but not parathyroid hormone - related protein ( PTHrP ) , correlated with increased bone metastasis in a population of human breast cancer cells . - pubmed
We hypothesized that IL-8 expression by breast cancer cells would either indirectly influence osteoclastogenesis via nearby stromal cells or directly influence osteoclast differentiation and activity . - pubmed
In the present study , we investigated the role of IL-8 in the process of osteoclast formation and bone resorption , which is associated with metastatic breast cancer . - pubmed
Together , these data implicate IL-8 in the osteolysis associated with metastatic breast cancer . - pubmed
[ Role of macroglobulins in chronic active arthritis ] . - pubmed
Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types . - pubmed
HIN-1 ( high in normal-1 ) is a candidate tumor suppressor identified as a gene silenced by methylation in the majority of breast carcinomas . - pubmed
To determine if , similar to breast carcinomas , HIN-1 is also silenced in tumors originating from other organs with high HIN-1 expression , we analyzed its expression and promoter methylation status in lung , prostate , and pancreatic carcinomas . - pubmed
Nearly all prostate and a significant fraction of lung and pancreatic carcinomas showed HIN-1 hypermethylation , and the majority of lung and prostate tumors lacked HIN-1 expression . - pubmed
In lung carcinomas , the degree of HIN-1 methylation differed among tumor subtypes ( P = 0.02 ) , with the highest level of HIN-1 methylation observed in squamous cell carcinomas and the lowest in small cell lung cancer . - pubmed
In lung adenocarcinomas , the expression of HIN-1 correlated with cellular differentiation status . - pubmed
Hypermethylation of the HIN-1 promoter was also frequently observed in normal tissue adjacent to tumors but not in normal tissue from noncancer patients , implying that HIN-1 promoter methylation may be a marker of premalignant changes . - pubmed
Thus , silencing of HIN-1 expression and methylation of its promoter occurs in multiple human cancer types , suggesting that elimination of HIN-1 function may contribute to several forms of epithelial tumorigenesis . - pubmed
The role of RAS oncogene in survival of patients with lung cancer : a systematic review of the literature with meta - analysis . - pubmed
The proto - oncogene RAS , coding for a 21 kDa protein ( p21 ) , is mutated in 20 % of lung cancer . - pubmed
Published studies on lung cancer assessing prognostic value of RAS mutation or p21 overexpression on survival were identified by an electronic search . - pubmed
The combined HR was 1.35 ( 95 % CI : 1.16 - 1.56 ) , showing a worse survival for NSCLC with KRAS2 mutations or p21 overexpression and , particularly , in adenocarcinomas ( ADC ) ( HR 1.59 ; 95 % CI 1.26 - 2.02 ) and in studies using PCR ( HR 1.40 ; 95 % CI 1.18 - 1.65 ) but not in studies using IHC ( HR 1.08 ; 95 % CI 0.86 - 1.34 ) . - pubmed
RAS appears to be a pejorative prognostic factor in terms of survival in NSCLC globally , in ADC and when it is studied by PCR . - pubmed
On the basis of hypothesis that chronic UVR may modulate differentiation as well as epidermal hyperplasia , we evaluated the modulation of markers of epidermal differentiation , such as transglutaminase 1 ( TGase 1 ) , filaggrin and loricrin , by chronic UVR in vivo . - pubmed
Targeting the platelet - derived growth factor receptor alpha with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts : implications as a potential therapeutic target . - pubmed
Platelet - derived growth factor receptor alpha ( PDGFRalpha ) is a type III receptor tyrosine kinase that is expressed on a variety of tumor types . - pubmed
This inhibition was seen in both transfected and tumor cell lines expressing PDGFRalpha . - pubmed
These data suggest that 3G3 may be useful for the treatment of tumors that express PDGFRalpha . - pubmed
Neurosteroids are potent blockers of neuronal low - voltage activated ( T - type ) Ca ( 2 + ) channels and potentiators of GABA ( A ) ligand - gated channels , but their effects in peripheral pain pathways have not been studied previously . - pubmed
These results strongly suggest that GABA ( A ) channels do not contribute to baseline pain transmission , but they can enhance anti - nociception mediated by blockade of T - type Ca ( 2 + ) channels . - pubmed
Proliferative signaling by store - operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins . - pubmed
Guanylyl cyclase C and accumulation of cGMP induced by bacterial heat - stable enterotoxins ( STs ) promote colon cancer cell cytostasis , serving as a tumor suppressor in intestine . - pubmed
Conversely , capacitative calcium entry through store - operated calcium channels ( SOCs ) is a key signaling mechanism that promotes colon cancer cell proliferation . - pubmed
These observations demonstrate that reciprocal regulation of guanylyl cyclase C signaling by capacitative calcium entry through SOCs represents one limb of a coordinated mechanism balancing colon cancer cell proliferation and cytostasis . - pubmed
They suggest that combining guanylyl cyclase C agonists and SOC inhibitors offers a novel paradigm for cGMP - directed therapy and prevention for colorectal tumors . - pubmed
It has also been proposed that potentiation of the AMPA receptor ( AMPAR ) function may be useful in the treatment of depression . - pubmed
Immunoreactivities of p62 , an ubiqutin - binding protein , in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis . - pubmed
An ubiquitin - binding protein , p62 , is one of the components of the ubiquitin - containing inclusions in several human neurodegenerative diseases . - pubmed
We examined the spinal cord from 28 ALS cases including two ALS with dementia and two ALS with basophilic inclusions , using antibody to p62 . - pubmed
The number of p62 - positive inclusions observed in the remaining anterior horn cells of each section was variable among the ALS cases . - pubmed
As far as we examined , the 11 non - ALS cases did not show any p62 immunoreactivities in the anterior horn cells . - pubmed
DESIGN : The authors performed a multicenter randomized controlled study to compare cardiac troponin release in patients receiving either volatile anesthetics or total intravenous anesthesia for cardiac surgery on the beating heart , which is an excellent model of human myocardial ischemia . - pubmed
Peak postoperative troponin I release was measured as a marker of myocardial necrosis . - pubmed
CONCLUSIONS : Myocardial damage measured by cardiac troponin release could be reduced by volatile anesthetics during OPCAB . - pubmed
In this scenario , rimonabant 's anti - obesity action is accompanied by favorable changes in markers for insulin resistance , C - reactive protein , adiponectin , tumor necrosis factor alpha ( TNFalpha ) . - pubmed
Adjuvant treatment of breast cancer : impact of monoclonal antibody therapy directed against the HER2 receptor . - pubmed
A humanised monoclonal antibody to the HER2 receptor , trastuzumab , has demonstrable single - agent activity in metastatic breast cancer and enhances the antitumour effects of chemotherapy . - pubmed
Comparative analysis of peripheral and localised cytokine secretion in glioblastoma patients . - pubmed
METHODS : To further understand the immunobiology of glioblastomas in clinical settings , we examined the secretion of four main cytokines in the peripheral blood and in primary cell cultures of 33 human glioblastoma patients . - pubmed
An ELISPOT methodology was used for the first time to examine Th1 , and Th2 cytokine secretion from both peripheral lymphocytes and glioma tumour cells . - pubmed
RESULTS : Th1 cytokines ( tumour necrosis factor ( TNF - alpha ) , interferon ( IFN - gamma ) were markedly reduced compared to control levels ( P=0.01 and P<0.001 , respectively ) , whereas in contrast , Th2 ( interleukin ( IL )- 4 and IL-10 ) were strongly expressed in both peripheral lymphocytes and glioma cell cultures ( P=0.05 and P<0.001 , respectively ) . - pubmed
Furthermore , ELISPOT methodology can be used for monitoring of cytokine secretion from tumour cells , in addition to the well - established peripheral cytokine secretion . - pubmed
Multiple myeloma in a 50 - year - old with an HLA - identical sibling . - pubmed
All - trans - retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF - kappaB. - pubmed
These results suggest that signaling events involving NF - kappaB and SOD2 may contribute to the effects of retinoids used in cancer therapy . - pubmed
Hypoxia abrogates the degradation of hypoxia - inducible factors ( HIF )- 1 and - 2 , that can then bind to the hypoxia response element within the Epo gene , activating its transcription . - pubmed
NO is a powerful vasodilator , insulin - sensitizer , inhibitor of atherothrombosis and apoptosis , and essential for progenitor mobilization . - pubmed
Men who have rising PSA values following treatment with either surgery or radiation have residual prostate cancer and are at very high risk of dying from prostate cancer within 10 years . - pubmed
Xenografts of MM tumors treated with this combination had marked increases in phospho - c - Jun - NH ( 2 )- kinase ( JNK)-positive cells and apoptosis , and corresponding reductions in tumor burden , tumor vasculature , and the expression of proliferating cell nuclear antigen and the proangiogenic cytokine vascular endothelial growth factor . - pubmed
These findings may have implications for therapeutic efforts using OXM as a long - acting GLP-1R agonist for the treatment of metabolic disorders . - pubmed
We tested the hypothesis that the C5b-9 membrane attack complex ( MAC ) localizes to sites of villous injury and modulates trophoblast function . - pubmed
Placental sections from pregnancies with no complications , intrauterine growth restriction , or preeclampsia were immunostained and the surface density for MAC and fibrin was determined by morphometric analysis . - pubmed
MAC localized to fibrin deposits in normal placentas , and especially in placentas from IUGR and preeclampsia . - pubmed
Our findings demonstrate that MAC associates with fibrin deposits at sites of villous injury in vivo . - pubmed
Tumor suppressor effect of follistatin - like 1 in ovarian and endometrial carcinogenesis : a differential expression and functional analysis . - pubmed
By performing differential expression analysis using annealing control primer - based reverse transcription ( RT)-polymerase chain reaction ( PCR ) on pooled complementary DNA ( cDNA ) from 45 endometrial and 36 ovarian cancers and their non - tumor samples , reduced expression of the follistatin - like 1 ( FSTL1 ) was identified . - pubmed
For in vitro functional study , full - length cDNA of FSTL1 was cloned and transiently transfected into the ovarian cancer cell line Ovca420 and endometrial cancer cell line AN3CA . - pubmed
By terminal uridine deoxynucleotidyl transferase dUTP nick end labeling and flow cytometric analysis , higher apoptotic activity and a remarkable increase in sub - G(1 ) cell population were observed in transfected cells , suggesting that FSTL1 induced apoptosis in cancer cells . - pubmed
Our findings suggested that a tumor suppressor role of FSTL1 may be important in ovarian and endometrial carcinogenesis . - pubmed
This study highlights that the SGT1 - mediated signalling cascade(s ) , which had previously only been demonstrated to be required for Arabidopsis resistance against biotrophic pathogens , is causally involved in F. - pubmed
The p21 codon 31*C- and DRD2 codon 313*T - related genotypes / alleles , but not XRCC1 codon 399 , hOGG1 codon 326 , and DRD1 - 48 polymorphisms , are correlated with the presence of leiomyoma . - pubmed
OBJECTIVE : To investigate whether the gene polymorphisms for p21 , X - ray repair cross - complementing group 1 ( XRCC1 ) , human 8 - oxoguanine glycosylase 1 ( hOGG1 ) , and dopamine D1 and D2 receptors ( DRD1 , - 2 ) are associated with leiomyoma susceptibility . - pubmed
RESULT(S ): The p21 codon 31(*)C- and DRD2 codon 313(*)T - related genotypes / alleles were associated with the presence of leiomyomas . - pubmed
The proportions of p21(*)CC / CA / AA and DRD2(*)CC / CT / TT in both groups were 27.5/68.3/4.2 % and 12.5/51.7/35.8 % ( leiomyoma ) ; and 14.3/51.8/33.9 % and 33.9/40.2/25.9 % ( nonleiomyoma ) . - pubmed
XRCC1 , hOGG1 , and DRD1 were not correlated with the presence of leiomyomas . - pubmed
XRCC1(*)GG / GA / AA , hOGG1(*)TT / TA / AA , and DRD1(*)GG / GA / AA were 54.2/37.5/8.3 % , 36.7/44.2/19.1 % , and 3.3/25.8/70.8 % ( leiomyoma ) ; and 48.2/47.3/4.5 % , 43.6/41/15.4 % , and 3.6/25/71.4 % ( nonleiomyoma ) . - pubmed
CONCLUSION(S ): The p21 codon 31(*)C- and DRD2 codon 313(*)T - related genotypes / alleles were associated with the presence of leiomyoma . - pubmed
XRCC1 , hOGG1 , and DRD1 were not correlated with leiomyoma development . - pubmed
Cancer cachexia is associated with the IL10 -1082 gene promoter polymorphism in patients with gastroesophageal malignancy . - pubmed
OBJECTIVE : We investigated the relation between cytokine polymorphisms ( IL1B -511 , IL6 -174 , IL10 -1082 , TNFA -308 , and LTA +252 ) and markers of nutritional status among patients with gastroesophageal cancer to determine whether any such association was reflected by cytokine concentrations in the tumor or plasma compartments . - pubmed
Tumor tissue cytokine protein concentrations ( n = 56 ) were determined by using the Cytometric Bead Array System . - pubmed
RESULTS : IL10 GG and IL6 CC polymorphisms were associated with elevated serum C - reactive protein concentrations , and the IL6 CC genotype was also associated with elevated tumor tissue cytokine concentrations . - pubmed
At diagnosis , the IL10 GG , but not the IL6 , genotype was linked with increased total weight loss : 4.9 % for AA , 7.1 % for AG , and 12.0 % for GG ( P = 0.007 ) . - pubmed
Serum C - reactive protein concentrations correlated with increased weight loss ( r = 0.24 , P & lt ; 0.001 ) . - pubmed
Compared with other genotypes , the IL10 GG genotype retained an independent association in determining the extent of weight loss on multivariate analysis ( 95 % CI : 0.52 , 3.43 ; P = 0.008 ) . - pubmed
CONCLUSION : These data suggest that the IL10 genotype of the host can influence the development of cachexia among patients with gastroesophageal malignancy . - pubmed
Consistent with the results in mice , increased MBL expression is linked with pregnancy failure . - pubmed
Univariate analysis showed that SOD activity was significantly decreased in ALS and GSH - Px activity was decreased in PD . - pubmed
After adjusting for demographic parameters and enzyme cofactors , we could emphasize a compensatory increase of SOD activity in PD . - pubmed
C2 - O - sLeX glycoproteins are E - selectin ligands that regulate invasion of human colon and hepatic carcinoma cells . - pubmed
We examined membrane expression of C2 - O - sLe ( X ) , selectin binding , invasion of human colon and hepatic carcinoma cell lines , and mRNA levels of alpha-2,3 fucosyltransferase ( FucT - III ) and core 2 beta-1,6 N - acetylglucosaminyltransferase ( C2GnT1 ) genes , necessary for C2 - O - sLe ( X ) synthesis , by quantitative reverse - transcriptase ( RT ) PCR . - pubmed
The cell lines that expressed C2GnT1 and FucT - III mRNA by quantitative RT - PCR were highly positive for C2 - O - sLe(X ) by flow cytometry , and colon carcinoma cells possessed highly active C2GnT1 enzyme . - pubmed
Gene knock - down of C2GnT1 in colon and hepatic carcinoma cells using short hairpin RNAs ( shRNA ) resulted in a 40 - 90 % decrease in C2 - O - sLe ( X ) and a 30 - 50 % decrease in E - selectin binding compared to control cells . - pubmed
Invasion of hepatic and colon carcinoma cells containing C2GnT1 shRNA was significantly reduced compared to control cells in Matrigel assays and C2GnT1 activity was down - regulated in the latter cells . - pubmed
Our findings indicate that C2GnT1 gene expression and the resulting C2 - O - sLe ( X ) carbohydrates produced mediate the adhesive and invasive behaviors of human carcinomas which may influence their metastatic potential . - pubmed
Akt , 14 - 3 - 3zeta , and vimentin mediate a drug - resistant invasive phenotype in diffuse large B - cell lymphoma . - pubmed
Development of resistance to the CHOP chemotherapeutic regimen ( cyclophosphamide , doxorubicin , vincristine , prednisone ) remains a major cause of treatment failure and mortality in approximately 40 % of patients with diffuse large B - cell lymphoma ( DLBCL ) . - pubmed
We established CHOP - resistant DLBCL cells as a model system to investigate molecular mechanisms involved in multidrug resistance . - pubmed
Two - dimensional differential in - gel ( DIGE ) analysis identified 10 differentially expressed proteins between CHOP - sensitive and -resistant DLBCL cells that play roles in glycolysis ( triosephosphate isomerase-1 , enolase-1 ) , cytoskeletal structure ( ezrin , vimentin , tubulin - specific chaperone B ) , purine biosynthesis ( serine hydroxymethyltransferase ) , calcium binding ( sorcin ) , and apoptosis ( p53 , 14 - 3 - 3zeta , Akt ) . - pubmed
Akt , 14 - 3 - 3zeta , and vimentin were up - regulated in CHOP - resistant DLBCL cells . - pubmed
We showed previously that siRNA - mediated knockdown of 14 - 3 - 3zeta reversed CHOP resistance in DLBCL cells ( Maxwell et al . - pubmed
Here we show that chemical inhibition of Akt overcomes CHOP resistance in DLBCL cells . - pubmed
Increased expressions of Akt , 14 - 3 - 3zeta , and vimentin were observed by Western blotting in primary DLBCL tissues relative to normal lymphatic tissue . - pubmed
The data implicate activation of an Akt-14 - 3 - 3zeta signaling pathway in promoting a multidrug - resistant phenotype associated with a vimentin - dependent invasive behavior in DLBCL cells . - pubmed
NGAL as an early biomarker of kidney disease in Joubert syndrome : three brothers compared . - pubmed
We measured neutrophil gelatinase - associated lipocalin ( NGAL ) , considered as an excellent predictor of kidney injury , to evaluate whether this biomarker might be an early biomarker for JBTS - related kidney disease . - pubmed
NGAL could represent an early indicator of renal damage useful to start an intensive nephrologic follow - up . - pubmed
Fatal delayed hemolytic transfusion reaction associated with anti - Di ( b ) and anti - E. We report the death of a 61 - year - old Japanese man massively transfused during and after emergency aortic surgery . - pubmed
The characteristic histopathological features and the presence of spindle cells expressing smooth muscle actin , collagen fibers and lymphocytes allowed for the diagnosis of liver IMT . - pubmed
gamma - Hydroxybutyric acid induces actions via the GABAB receptor in arousal and motor control - related nuclei : implications for therapeutic actions in behavioral state disorders . - pubmed
Aortic valve stenosis and atrial fibrillation influence plasma fibulin-1 levels in patients treated with coronary bypass surgery . - pubmed
In this study , we addressed the hypothesis that fibulin-1 levels reflect myocardial fibrosis . - pubmed
Patients with AS or atrial fibrillation ( AF ) had significantly higher fibulin-1 levels compared to those with coronary artery disease only ( p = 0.005 ) . - pubmed
Patients with preoperatively diagnosed chronic AF had significantly higher levels of fibulin-1 compared to those without ( p = 0.004 ) . - pubmed
CONCLUSION : This study shows that plasma fibulin-1 levels are increased in patients with AS and AF compared to patients with coronary disease only . - pubmed
Our study results suggest fibulin-1 , a vascular extracellular matrix ( ECM ) protein , as a marker of ECM turnover perhaps due to the increased myocardial stretch that is related to pressure overload . - pubmed
The discovery that Rett syndrome ( RTT ) is caused by mutation of the methyl - CpG - binding - protein MeCP2 provided a major breakthrough in understanding the neurodevelopmental disorder and accelerated MeCP2 research . - pubmed
Association study of cathepsin D gene polymorphism in Iranian patients with sporadic late - onset Alzheimer ' s disease . - pubmed
A key event in the pathogenesis of AD is the deposition of beta - amyloid peptide , which is derived from the amyloid precursor protein by beta - and gamma - secretases . - pubmed
An exonic C T polymorphism at position 224 of the CTSD gene ( rs : 17571 ) has been shown to be associated with the enzyme function of CTSD and with AD . - pubmed
Our results indicate that CTSD genotype is associated with the disease and a combination of the above risk factors significantly alters the risk for developing AD . - pubmed
The Biological Role of PI3 K Pathway in Lung Cancer . - pubmed
Numerous downstream molecular pathways , such as EGF / RAS / RAF / MEK / ERK and PI3K / AKT / mTOR are identified as having a key role in the pathogenesis of various forms of human cancer , including lung cancer . - pubmed
In this review article , we investigate thoroughly the biological role of PI3 K pathway in lung cancer and its contribution in the development of future therapeutic strategies . - pubmed
BTG2 overexpression increases the radiosensitivity of breast cancer cells in vitro and in vivo . - pubmed
In this study , we investigated the effect of BTG2 gene overexpression on the radiosensitivity of breast cancer cells in vitro and in vivo . - pubmed
Results show that in human breast cancer cell line MCF-7 stably overexpressing BTG2 gene , cell sensitivity to ionizing radiation increased . - pubmed
The findings indicate for the first time that BTG2 can improve the radiosensitivity of breast cancer cells by affecting cell cycle distribution , enhancing radiation - induced apoptosis , and inhibiting DNA repair - related protein expression . - pubmed
We found that RSV infection induces a non - canonical ER stress response with preferential activation of the inositol - requiring enzyme 1 ( IRE1 ) and activated transcription factor 6 ( ATF6 ) pathways with no concomitant significant activation of the protein kinase R - like ER kinase ( PERK ) pathway . - pubmed
Our data characterize , for the first time , the nature of the ER stress response in the setting of RSV infection and identify the IRE1 stress pathway as a novel cellular anti - RSV defense mechanism . - pubmed
RESULTS : Manumycin treatment resulted in significant decreases in the viabilities of the two prostate cancer cell lines in a dose - dependent manner through apoptosis , and this apoptosis involved caspase-9 activation . - pubmed
A specific inhibitor of caspase-9 protected cells from caspase-3 activation , apoptosis , and cytotoxicity induced by manumycin . - pubmed
CONCLUSION : Our data suggest that manumycin induces apoptosis in prostate cancer cells through regulation of the Bcl-2 family involving caspase-9 activation . - pubmed
METHODS : Data are from individuals in the Detroit Neighborhood Health Study tested for herpes simplex virus-1 ( HSV-1 ) and cytomegalovirus ( CMV ) seropositivity / immunoglobulin G ( IgG ) antibody levels ( N=263 ) as well as interleukin-6 ( IL-6 ) ( N=245 ) and C - reactive protein ( CRP ) ( N=236 ) levels and assessed for incident depression via the Patient Health Questionnaire-9 . - pubmed
Linear and logistic regression models were used to examine associations between pathogen seropositivity / IgG antibody levels , pro - inflammatory markers and incident depression over approximately one - year of follow - up . - pubmed
RESULTS : For every one unit increase in CMV IgG antibody level , the odds of incident depression increased by 26 % and individuals with IgG antibody levels in the highest quartile had over three times greater odds of incident depression ( odds ratio 3.87 , 95 % confidence interval 1.47 , 10.19 ) , compared to those in the lower three quartiles . - pubmed
Neither CMV or HSV-1 seropositivity nor HSV-1 IgG antibody level were associated with IL-6 or CRP levels at Wave 1 , nor were IL-6 or CRP levels associated with incident depression at Wave 2 . - pubmed
Synchronous GH- and prolactin - secreting pituitary adenomas . - pubmed
We report a case of synchronous secretory pituitary adenomas in a woman who initially presented with elevated prolactin levels . - pubmed
Pathological analysis demonstrated one tumor as a prolactinoma , and the other tumor as a GH - secreting adenoma . - pubmed
This case highlights that GH and prolactin level elevation is not always from co - secretion by the same adenoma . - pubmed
In the setting of elevated GH and prolactin levels , one can not assume that they are co - secreted by the same adenoma . - pubmed
A core needle biopsy from the renal mass demonstrated numerous histiocytoid that were positive for CD163 and S100 protein . - pubmed
Moreover , scintigraphic images from cell plates and mouse xenografts showed stronger signals from opt - hNIS - expressing cells than hNIS - expressing cells , and radioactivity uptake by opt - hNIS - expressing tumors was 2.3 - fold greater than that by hNIS - expressing tumors . - pubmed
To test the efficacy of radioiodine therapy , mouse xenograft models were established with cancer cells expressing hNIS or opt - hNIS . - pubmed
131I treatment reduced tumor sizes of hNIS- and opt - hNIS - expressing tumors to 0.57- and 0.27- fold , respectively , compared to their sizes before therapy , suggesting an improved therapeutic effect of opt - hNIS . - pubmed
46,XY Gonadal Dysgenesis due to a Homozygous Mutation in Desert Hedgehog ( DHH ) Identified by Exome Sequencing . - pubmed
The gonads of one patient showed partial gonadal dysgenesis with loss of Leydig cells in tubular areas with seminoma in situ and a hyperplasia of Leydig cell - like cells expressing CYP17A1 in more dysgenetic parts of the gonad . - pubmed
CONCLUSION : Mutations in DHH play a role in 46,XY gonadal dysgenesis and are associated with seminoma formation and a neuropathy with minifascicle formation . - pubmed
The lysyl oxidase inhibitor beta - aminopropionitrile reduces body weight gain and improves the metabolic profile in diet - induced obesity in rats . - pubmed
The lysyl oxidase ( LOX ) family of amine oxidases , including LOX and LOX - like ( LOXL ) isoenzymes , controls ECM maturation , and upregulation of LOX activity is essential in fibrosis ; however , its involvement in adipose tissue dysfunction in obesity is unclear . - pubmed
In this study , we observed that LOX is the main isoenzyme expressed in human adipose tissue and that its expression is strongly upregulated in samples from obese individuals that had been referred to bariatric surgery . - pubmed
Interestingly , treatment with beta - aminopropionitrile ( BAPN ) , a specific and irreversible inhibitor of LOX activity , attenuated the increase in body weight and fat mass that was observed in obese animals and shifted adipocyte size toward smaller adipocytes . - pubmed
BAPN also ameliorated the increase in collagen content that was observed in adipose tissue from obese animals and improved several metabolic parameters - it ameliorated glucose and insulin levels , decreased homeostasis model assessment ( HOMA ) index and reduced plasma triglyceride levels . - pubmed
Furthermore , in white adipose tissue from obese animals , BAPN prevented the downregulation of adiponectin and glucose transporter 4 ( GLUT4 ) , as well as the increase in suppressor of cytokine signaling 3 ( SOCS3 ) and dipeptidyl peptidase 4 ( DPP4 ) levels , triggered by the HFD . - pubmed
Therefore , our data provide evidence that LOX plays a pathologically relevant role in the metabolic dysfunction induced by obesity and emphasise the interest of novel pharmacological interventions that target adipose tissue fibrosis and LOX activity for the clinical management of this disease . - pubmed
Effectiveness of Botulinum Toxin for Shoulder Pain Treatment : A Systematic Review and Meta - Analysis . - pubmed
OBJECTIVE : To evaluate the current evidence of the effectiveness of botulinum toxin ( BTX ) treatment for shoulder pain . - pubmed
miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long - Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors . - pubmed
Aromatase inhibitors ( AI ) have become the first - line endocrine treatment of choice for postmenopausal estrogen receptor - positive ( ER (+ ) ) breast cancer patients , but resistance remains a major challenge . - pubmed
This effect was ER dependent as breast cancer cells with undetectable levels of ER failed to exhibit metabolic plasticity . - pubmed
MDW was positively correlated with PC ( r=0.156 , P=0.047 ) and CRP ( r=0.591 , P<0.001 ) . - pubmed
INTRODUCTION : Adiponectin ( APN ) , an adipocytokine , exerts protective effects on cardiac remodeling , while angiotensin II ( Ang II ) induces hypertension and vascular remodeling . - pubmed
The potential protective role of APN on the vasculature during hypertension has not been fully elucidated yet . - pubmed
METHODS AND RESULTS : Rat aortic tissues were used to investigate the effect of APN on Ang II - induced vascular remodeling and hypertrophy . - pubmed
We investigated whether nitric oxide ( NO ) , the RhoA / ROCK pathway , actin cytoskeleton remodeling , and reactive oxygen species ( ROS ) mediate the anti - hypertrophic effect of APN . - pubmed
The hypertrophic response to Ang II was associated with a significant increase in RhoA activation and vascular force production , which were prevented by APN and SNAP . - pubmed
RESULTS : Regulatory T ( Treg ) cells and their cytokines , primarily interleukin ( IL ) 10 and transforming growth factor beta , suppress T - helper type 2 immune responses and control allergic diseases in many ways . - pubmed
DISCUSSION : Recurrent elevations in cortisol in response to hypoglycemia may be the underlying pathology leading to suppression of gonadotropin - releasing hormone ( GnRH ) release . - pubmed
RESULTS : The anti - HSV - UL29 siRNA swarm alleviated HSV infection symptoms , inhibited viral shedding and replication and had a favourable effect on mouse survival . - pubmed
CONCLUSIONS : Treatment with anti - HSV - UL29 siRNA swarm reduced symptoms and viral spread in HSV infection of mice and also inhibited local viral replication in mouse corneas . - pubmed
Oleanolic acid ( OA ) regulates inflammation and cellular dedifferentiation of chondrocytes via MAPK signaling pathways . - pubmed
These results suggest that OA induces loss of type II collagen expression via the p38 pathway and induces inflammation through the p38 and ERK pathways in rabbit articular chondrocytes . - pubmed
Cerebrospinal fluid / serum albumin ratio is one of the most informative parameters for blood - brain barrier ( BBB ) integrity in cases of central nervous system ( CNS ) infectious diseases . - pubmed
The results demonstrated typical patterns which prove albumin to be the main modulator of protein dynamics and at the same time explicates the complex pathophysiological mechanisms involved in BBB disruption and intrathecal immune response in CNS infections . - pubmed
t(11;14)-positive mantle cell lymphomas lacking cyclin D1 ( CCND1 ) immunostaining because of a CCND1 mutation or exclusive expression of the CCND1b isoform . - pubmed
Lymphomas with pseudo - double - hit BCL6 - MYC translocations due to t(3;8)(q27;q24 ) are associated with a germinal center immunophenotype , extranodal involvement , and frequent BCL2 translocations . - pubmed
High - grade B - cell lymphomas with MYC , BCL2 , and/or BCL6 rearrangements , " double - hit " or " triple - hit " lymphomas ( DTHL ) , are aggressive neoplasms associated with a poor prognosis . - pubmed
A t(3;8)(q27;q24 ) rarely occurs in B - cell lymphomas that results in a unique " pseudo - double - hit " BCL6 - MYC fusion , indistinguishable by interphase fluorescence in situ hybridization ( FISH ) from more conventional DTHL with independent MYC and BCL6 translocations . - pubmed
When compared to two large published DTHL cohorts , t(3;8)(q27;q24 ) lymphomas less often expressed BCL2 ( P & lt ; .01 ) , had a greater likelihood of extranodal involvement ( P & lt ; .01 ) , and more frequently appeared triple - hit by FISH analysis ( P & lt ; .01 ) . - pubmed
TAA and AAD share common etiology as monogenic diseases linked to transforming growth factor beta signaling pathway , extracellular matrix defect , or smooth muscle cell protein mutations . - pubmed
The study elucidates the effect of alpha - linolenic acid ( ALA ) on mitochondrial stress , hypoxic cancer microenvironment , and intervention of cholinergic anti - inflammatory pathway using N - methyl - N - nitrosourea ( MNU ) induced estrogen receptor ( ER+ ) mammary gland carcinoma and Caenorhabditis elegans model , respectively . - pubmed
It was concluded that ALA persuaded the mitochondrial stress , activation of downstream cholinergic anti - inflammatory markers , and favorable regulation of hypoxia microenvironment through inhibition of fatty acid synthase and sterol regulatory element - binding protein . - pubmed
We have previously shown that agricultural organic dust extract ( ODE ) , with abundant microbial component diversity , activates TLR - induced airway inflammation . - pubmed
Increased Muc5ac levels in MyD88 - deficient mice were also not explained by augmented inflammation , IL-17A , or neutrophil elastase levels . - pubmed
By exploiting the paramagnetic properties of deoxygenated hemoglobin in venous blood using magnetic resonance imaging ( MRI ) quantitative susceptibility mapping ( QSM ) , we aimed to explore venous density and oxygen saturation ( SvO2 ) in patients with a brain AVM . - pubmed
These results suggest that PTN may be a novel candidate to improve sensorineural hearing loss treatment in the future . - pubmed
Regulation of the SIRT1 signaling pathway in NMDA - induced Excitotoxicity . - pubmed
The present study is to investigate the potential pathway of SIRT1 in the SH - SY5Y cell line as an in vitro model of NMDA - induced neurotoxicity . - pubmed
Therefore , the study suggests that inhibition of Ca2 + -PKC - HuR - SIRT1 pathway could be an effective strategy for preventing certain neurological diseases related to NMDA excitotoxicity . - pubmed
PI3K / AKT signaling is known to regulate cancer metabolism , but whether metabolic feedback regulates the PI3K / AKT pathway is unclear . - pubmed
PPP metabolites , in turn , reinforce AKT activation and further promote cancer metabolic reprogramming by blocking the expression of the AKT inhibitor PHLDA3 . - pubmed
Importantly , PTEN null human cancer cells and in vivo murine models are sensitive to anti - PPP treatments , suggesting the importance of the PPP in maintaining AKT activation even in the presence of a constitutively activated PI3 K pathway . - pubmed
Our study suggests that blockade of this reciprocal crosstalk mechanism may have a therapeutic benefit for cancers with PTEN loss or PI3K / AKT activation . - pubmed
Identification of METTL3 as an Adverse Prognostic Biomarker in Hepatocellular Carcinoma . - pubmed
Joint effects analysis showed the predictive capacity of combining METTL3 , YTHDF2 , and ZC3H13 for HCC OS . - pubmed
CNV and DNA methylation , but not somatic mutations , might contribute to the abnormal upregulation of METTL3 in HCC . - pubmed
Significantly altered genes , microRNAs , and lncRNAs were identified , and a ceRNA regulatory network was constructed to explain the upregulation of METTL3 in HCC . - pubmed
CONCLUSIONS : Our study identified several m6A - related genes , especially METTL3 , that could be potential prognostic biomarkers in HCC . - pubmed
Erratum : Long Noncoding RNA H19 Facilitates Small Cell Lung Cancer Tumorigenesis Through miR-140 - 5p / FGF9 Axis [ Corrigendum ] . - pubmed
PRAME expression in melanocytic proliferations with intermediate histopathologic or spitzoid features . - pubmed
BACKGROUND : PRAME ( PReferentially expressed Antigen in MElanoma ) has shown utility in distinguishing melanoma from benign melanocytic lesions , but knowledge of its expression pattern in intermediate melanocytic and spitzoid proliferations is limited . - pubmed
METHODS : Immunohistochemical expression of PRAME was examined in 112 melanocytic proliferations with intermediate histopathologic or spitzoid features . - pubmed
Nearly all non - spitzoid melanomas ( 23/24 ; 95.8 % ) demonstrated diffuse PRAME expression . - pubmed
PRAME was completely negative in 95.6 % ( 43/45 ) of mitotically - active nevi , traumatized nevi , nevi with persistent / recurrent features , and dysplastic nevi . - pubmed
Most Spitz nevi ( 15/20 ) and atypical Spitz tumors ( 10/13 ) entirely lacked PRAME expression . - pubmed
One Spitz nevus , one atypical Spitz tumor , and one case of spitzoid melanoma ( 1/2 ) demonstrated diffuse PRAME expression . - pubmed
CONCLUSIONS : Although diffuse PRAME expression is generally limited to malignant melanoma , benign Spitz nevi and atypical Spitz tumors can infrequently express diffuse PRAME . - pubmed
PRAME immunohistochemistry can be useful in the evaluation of atypical melanocytic proliferations with intermediate histopathologic features but should be interpreted with caution in the setting of spitzoid neoplasms . - pubmed
The purpose of the present study was to investigate the endocrine disrupting toxicity of CYP , MAT , and CYP + MAT to 5 - month - old male zebrafish ( Danio rerio ) . - pubmed
The human forearm technique was employed to determine changes in plasma levels and peripheral fluxes of TG , FFA and glycerol in a group of insulin independent diabetics before and after administration of sodium pentosan polysulphate . - pubmed
Use of recombinant erythropoietin in thalassemic patients on dialysis . - pubmed
We studied the therapeutic benefit of recombinant human erythropoietin ( rHuEPO ) in dialysis patients with thalassemia minor . - pubmed
Four of the 40 randomly selected patients ( 22 on hemodialysis [ HD ] , 18 on continuous ambulatory peritoneal dialysis [ CAPD ] ) were identified to be thalassemic prior to a trial of rHuEPO ( alpha - thalassemia trait in three and beta - thalassemia minor in one ) . - pubmed
All nonthalassemic patients reached a target hemoglobin of 10 g / dL at week 16 , with an average maintenance dose of 120 + /- 7.8 U / kg / wk , but the hemoglobin was increased by only 1 g / dL in the thalassemic patients receiving 175 U / kg / wk . - pubmed
Following cessation of rHuEPO therapy for 6 weeks , all four thalassemic patients and 18 randomly selected nonthalassemic patients received a fixed dose of rHuEPO 4,000 U / wk ( equivalent to 80 U / kg / wk ) for 16 weeks . - pubmed
The hemoglobin remained unchanged in the thalassemic patients , but a progressive and significant increase of hemoglobin was observed in the nonthalassemic patients . - pubmed
At the last phase of the study , the thalassemic patients received rHuEPO at a dose of 100 or 125 U / kg / wk with 4 - weekly increments of 25 U / kg / wk until their hemoglobin reached 10 g / dL. - pubmed
One patient developed uncontrolled hypertension with a dose of 150 U / kg / wk , and one reached the target hemoglobin at a dose of 200 U / kg / wk. - pubmed
Although the PHA - induced mitogen response of lymphocytes from the other three lymphoid compartments remained suppressed throughout the study period , the response to the mitogens Con - A and PWM generally returned to normal or supranormal levels by the seventh postburn day , Therefore it appears that the effect of a thermal injury on lymphocyte function varies according to the lymphocyte compartment examined and the mitogen tested . - pubmed
Due to critical amino acid changes in the 72 - 89 sequence , the determinant of human ( Hu ) basic protein ( BP ) that induces experimental autoimmune encephalomyelitis ( EAE ) in Lewis rats most likely differs from rat and guinea pig BP . - pubmed
T cells specific for the 87 - 99 determinant recognized both Hu- and Rt - BP , were highly encephalitogenic , and accounted for the experimental autoimmune encephalomyelitis - inducing activity of the Hu - BP line . - pubmed
Seasonal and mood independence of low basal prolactin secretion in premenopausal women with seasonal affective disorder . - pubmed
To test hypotheses of opposing roles of dopamine and serotonin in prolactin secretion in seasonal affective disorder , the authors determined basal serum prolactin concentrations for premenopausal women , eight with and 14 without seasonal affective disorder , in late afternoon during the follicular phase of the menstrual cycle ( and a subgroup during the luteal phase ) in winter and summer . - pubmed
Despite their significantly higher Hamilton depression scale scores in winter than in summer , the patients had significantly lower prolactin concentrations than the control subjects in both seasons . - pubmed
These results suggest that low prolactin secretion may be a trait characteristic in seasonal affective disorder . - pubmed
We have previously reported that 5 '- aminothymidine ( 5 '- AdThd ) , an antagonist of the feedback inhibition exerted by dTTP that regulates thymidine kinase , enhances the uptake and cytotoxicity of 5 - iododeoxyuridine in various human bladder cancer cell lines but not in normal human urothelial cells ( HU ) propagated in vitro . - pubmed
The patient with deposition of immunoglobulin along the perineurium had severe demyelination and severe peripheral sensory - motor neuropathy , while the patient with immunoglobulin deposition along the myelin sheaths had a slight sensory neuropathy which had not progressed for 4 years . - pubmed
Predicting bone marrow iron stores in anemic patients in a community hospital using ferritin and erythrocyte sedimentation rate . - pubmed
A two - dimensional linear graphic relationship between ferritin and ESR correctly identified six of nine iron - deficient patients and 32 of 34 iron - present patients . - pubmed
Nine immunologically characterized cleaved FCC lymphomas with sclerosis and 14 reactive lymph nodes with follicular hyperplasia were investigated by special staining methods , electron microscopy , and immunohistochemical studies with antibodies to types I , III , IV , and V collagen , laminin , and fibronectin . - pubmed
Weak pericellular staining for type V collagen was present in eight of nine lymphomas and half of the control lymph nodes . - pubmed
These studies suggest that the increased amounts of extracellular matrix in cleaved FCC lymphomas are produced primarily by fibroblasts and myofibroblasts and represent predominantly fibronectin and types I , III , and V collagen . - pubmed
[ Evaluation of the behavior of the antistreptokinase titer , erythrocyte sedimentation and antistreptolysin titer in focal diseases of tonsillar etiology ] . - pubmed
Norepinephrine and renin activity in chronic renal failure . - pubmed
To assess the interaction between adrenergic activity and blood pressure regulation in patients with chronic renal failure , plasma norepinephrine ( NE ) and plasma renin activity ( PRA ) were measured before and after vigorous ultrafiltration . - pubmed
These results indicate that hemodialysis mobilizes the renin - angiotensin system to maintain hypertension in a greater proportion of dialysis patients than previously supposed and that impaired renin release following hypotension may represent uremic autonomic dysfunction . - pubmed
Structural and functional differences of subspecies of apoA - I - containing lipoprotein in patients with plasma cholesteryl ester transfer protein deficiency . - pubmed
We propose that the structure and function of LpA - I and LpA - I / A - II are severely affected in the presence of CETP deficiency . - pubmed
The following parameters were investigated : sex , age , serum lipid levels ( total cholesterol , HDL cholesterol , triglycerides ) , presence of diabetes mellitus , height , body mass index ( BMI ) , and average daily consumption of coffee , tobacco and alcohol . - pubmed
[ The antibacterial effects of homologous interferons in an experimental staphylococcal infection ] . - pubmed
Homologous interferons ( IF ) of the 1st and 2nd types are studied for their effect on the course of experimental staphylococcal infection . - pubmed
Vicinal dihaloalkanes are transformed by glutathione S - transferase - catalyzed reactions to mutagenic and nephrotoxic S -( 2 - haloethyl ) glutathione S - conjugates . - pubmed
Beta - Lyase - dependent metabolism of halovinyl cysteine S - conjugates yields electrophilic thioketenes , whose covalent binding to cellular macromolecules is responsible for the observed toxicity of the parent compounds . - pubmed
Reports of different awareness of hypoglycemic symptoms during hypoglycemia induced by human insulin ( HI ) and porcine insulin ( PI ) suggest a modulatory influence of insulin on sensory processing . - pubmed
Differences between the effects of the insulins were consistently apparent after 20 min of hypoglycemia , which indicates a short - term action of the hormone . - pubmed
A significant proportion of LHON patients had circulating antibodies to tubulin protein . - pubmed
Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy ( EPM1 ) Progressive myoclonus epilepsy of the Unverricht - Lundborg type ( EPM1 ) is an autosomal recessive inherited form of epilepsy , previously linked to human chromosome 21q22.3 . - pubmed
Two mutations , a 3 ' splice site mutation and a stop codon mutation , were identified in the gene encoding cystatin B in EPM1 patients but were not present in unaffected individuals . - pubmed
These results provide evidence that mutations in the gene encoding cystatin B are responsible for the primary defect in patients with EPM1 . - pubmed
OBJECTIVE : To evaluate the value of fecal leukocytes , fecal occult blood , fecal lactoferrin and combination of fecal leukocytes with clinical data in the workup of patients with inflammatory diarrhea . - pubmed
Our aim was to determine the effects of As ( III ) pretreatment on the acute toxicity of PA and its possible relationship with the effects of As ( III ) on P-450 - dependent monooxygenase activities . - pubmed
Our results also indicated that the increase in PA toxicity caused by As ( III ) pretreatment , could also be related to the CYP2B2 isoform , since decreases in CYP2B2 - dependent BROD activity were observed in both As ( III ) and As ( III ) + PA groups , but not in PA - treated animals , suggesting that CYP2B2 is involved in PA detoxification . - pubmed
METHODS : We analyzed growth and GH secretion in 60 children in complete remission after treatment by chemotherapy and surgery for malignant solid tumors . - pubmed
The growth rate in conjunction with the GH response to clonidine provides a sensitive measure of GHD associated with chemotherapy . - pubmed
Mice homozygous for a deletion in the gene for CEBPalpha ( C / EBPalpha-/- mice ) die shortly after birth of hypoglycemia , with no detectable hepatic PEPCK mRNA and negligible hepatic glycogen stores . - pubmed
Half of the mice homozygous for a deletion in the gene for CEBPbeta ( C / EBPbeta-/- mice ) have normal glucose homeostasis ( phenotype A ) , and the other half die at birth of hypoglycemia due to a failure to express the gene for PEPCK and to mobilize hepatic glycogen ( phenotype B ) . - pubmed
Insulin deficiency induces C / EBPalpha and PEPCK gene transcription in the livers of 19 - day fetal rats , whereas dibutyryl cyclic AMP ( Bt2cAMP ) increases the expression of the gene for C / EBPbeta and causes a transient burst of PEPCK mRNA . - pubmed
Human cytomegalovirus late - phase maturation is blocked by stably expressed UL32 antisense mRNA in astrocytoma cells . - pubmed
Thus , hypoglycaemia caused LH inhibition after higher doses of IGF-1 , which counteracted ( E- ) or overcame ( E+ ) the stimulatory effects on LH seen after lower doses . - pubmed
OBJECTIVE : We applied isolated IgE - binding components ( major allergens ) in the technique of bronchial allergen challenge to determine the role of patient characteristics in the early asthmatic response ( EAR ) . - pubmed
Moreover , no significant contribution of these indices of IgE - mediated hypersensitivity to the prediction of PD20allergen by multilinear regression models with PC20histamine was found . - pubmed
Increased serum concentrations of secretory leukoprotease inhibitor in patients with primary Sjogren ' s syndrome . - pubmed
OBJECTIVE : We sought to assess whether serum levels of SLPI in patients with primary Sjogren ' s syndrome ( SS ) are elevated and correlated with conventional and laboratory indices of disease activity . - pubmed
PATIENTS AND METHODS : SLPI levels were determined by ELISA of serum from 21 primary SS , and 26 age - matched normal controls . - pubmed
RESULTS : Increased SLPI concentrations were found in primary SS patients ( p & lt ; 0.01 ) . - pubmed
CONCLUSION : Determination of serum SLPI may provide a new simple noninvasive technique for evaluation of primary SS . - pubmed
Roles of histamine receptor in a guinea pig asthma model . - pubmed
Histamine plays an important role in bronchoconstriction mediated by histamine receptors which provoke bronchial asthma attack . - pubmed
These findings suggest a close association of Histamine receptors both H1 and H2 in the pathology of asthma . - pubmed
Budd - Chiari syndrome associated with factor V leiden mutation : a report of 6 patients . - pubmed
Resistance to activated protein C caused by factor V Leiden mutation has been recently identified as a major cause of thrombophilia . - pubmed
We report 6 patients with Budd - Chiari syndrome associated with factor V Leiden mutation combined with another acquired thrombophilic state ( myeloproliferative disorder and lupus anticoagulant in 3 cases ) and without another thrombophilic disorder in the other 3 cases . - pubmed
We conclude that factor V Leiden mutation should be evaluated in any case of hepatic vein occlusion because the prevalence of this mutation in the general population is high . - pubmed
spiralis muscular larva antigens ( TsMLA ) against several sera from patients with other parasitic diseases by ELIB ( enzyme - linked immunoblotting technique ) were studied . - pubmed
The cross reactions of TsMLA against Schistosoma japonicum may be differentiated on the positive reaction bands of 44/45 , 51/53 , 62/64 and 100 KDa proteins which was specific to the chronic schistosomiasis using the TsMLA by means of ELIB . - pubmed
MATERIAL AND METHODS : In a rat model of 30 min of intestinal ischemia and reperfusion , the number of PMNs was manipulated : group A , control ; group B , leukopenia induced by cyclophosphamide ; group C , leukocytosis induced by granulocyte colony - stimulating factor ( G - CSF ) . - pubmed
In group C , tissue pH was significantly lower than in other groups during I / R. CONCLUSION : Leukocytosis induced by G - CSF exerts a prolonged effect on ATP during I / R and leukocyte depletion helps protect against the I / R injury . - pubmed
One highly conserved feature of the Wilms ' tumour suppressor gene , WT1 , is the potential , following alternative pre - mRNA splicing , to insert three amino acids ( KTS ) between the third and fourth zinc fingers . - pubmed
Pteridin - dependent hydroxylases as autoantigens in autoimmune polyendocrine syndrome type I. - pubmed
We have earlier reported the identification of tryptophan hydroxylase ( TPH ) and tyrosine hydroxylase ( TH ) as autoantigens in APS I associated with intestinal dysfunction and alopecia , respectively . - pubmed
Of the APS I patients , 25 % had PAH antibodies , and no reactivity was detected in the controls . - pubmed
No association with the main clinical components of APS I was found with PAH antibodies . - pubmed
Altogether , 59 sera from the 94 APS I patients reacted with at least one of TPH , TH , or PAH , whereas 35 showed no reactivity . - pubmed
The chorioallantoic membrane ( CAM ) of the fertilized egg allows grafting of human melanomas for short - term investigations and offers the opportunity to investigate the behavior of metastasizing cells and the release of S100beta into peripheral blood . - pubmed
Tissue from one primary melanoma as well as cutaneous and subcutaneous metastases of 10 melanoma patients with elevated levels of S100 in the peripheral blood before surgery were transplanted onto the CAM of chick embryos at day 5/6 of development . - pubmed
Samples deriving from melanoma xenografts contained highly elevated levels of S100 protein in 80 % of cases . - pubmed
The putative mutants were tested for VirB8 function by the ability to complement a virB8 deletion mutant in tumor formation assays . - pubmed
When introduced into the wild - type strain , virB8(S87L ) partially suppressed the tumor forming ability of the wild - type protein . - pubmed
Expression of alpha - synuclein in a human glioma cell line and its up - regulation by interleukin-1beta . - pubmed
Although alpha - synuclein is expressed primarily in neurons , it is a major component of oligodendroglial and astrocytic inclusions in several neurodegenerative diseases . - pubmed
alpha - Synuclein mRNA and protein were detected in U251 human astrocytic glioma cells and normal human astrocytes , and the levels were increased in the former , but not in the latter , by stimulation with interleukin-1beta in a time- and concentration - dependent manner . - pubmed
To determine the reference intervals of urinary albumin , immunoglobulin G , transferrin , alpha 1 microglobulin , and N - acetyl - beta - D - glucosaminidase , we measured those components and creatinine in urine from men with normal blood pressure(systolic & lt ; or = 139 mmHg and diastolic & lt ; or = 89 mmHg ) , HbA1c & lt ; or = 5.8 % and negative qualitative tests of urinary protein and hematuria . - pubmed
The icv infusion of the selective glucocorticoid receptor antagonist RU38486 blocked the hyperphagic effects of twice - daily icv injections of DEX in both sexes . - pubmed
Sensitive and specific detection of circulating cancer cells in patients with hepatocellular carcinoma ; detection of human telomerase reverse transcriptase messenger RNA after immunomagnetic separation . - pubmed
CONCLUSIONS : These results strongly suggest that detection of hTERT mRNA after immunomagnetic separation is a specific and sensitive tool to detect CC cells and that it would provide useful source for further investigation of cancer metastasis . - pubmed
[ Histochemistry of nonspecific esterase activities in human tumors . - pubmed
[ PATHOGENESIS AND THERAPY OF RETINAL DETACHMENT ] . - pubmed
In this study , we examined the potential integration and distribution of GX-12 , a new therapeutic vaccine for HIV infection , at various times in muscles and reproductive organs of rats . - pubmed
Endothelial nitric oxide synthase gene polymorphisms in Behcet ' s disease and rheumatic diseases with vasculitis . - pubmed
OBJECTIVE : To assess potential associations between Korean Behcet ' s disease ( BD ) or other rheumatic diseases with vasculitis and two polymorphisms of the endothelial nitric oxide synthase ( eNOS ) gene , which include the Glu298Asp polymorphism in exon 7 and a variable number of tandem repeats ( VNTR ) polymorphism in intron 4 . - pubmed
Additionally , HLA - B51 typing was performed in the BD group and controls by a two step PCR sequence - specific primers method . - pubmed
Even after stratification of the BD group based on the results of HLA - B51 testing , a significant association of the Glu298Asp polymorphism was still found ( p=0.002 , Mantel - Haenszel weighted odds ratio 4.3 , 95 % confidence interval 1.7 to 10.9 ) . - pubmed
Distribution of the genotype frequencies in two eNOS gene polymorphisms was similar in connective tissue diseases - associated vasculitis and primary vasculitic syndromes . - pubmed
CONCLUSION : The Glu298Asp polymorphism in exon 7 of the eNOS gene seems to be a susceptibility gene for Korean BD and other rheumatic diseases . - pubmed
BACKGROUND : The association between sympathetic activation and mortality in chronic heart failure and the favorable effect of beta blocking drugs has raised the possibility of therapeutic efficacy for central sympathetic inhibition with sustained - release ( SR ) moxonidine , an imidazoline receptor agonist . - pubmed
The use of streptokinase - streptodornase in the treatment of hemothorax . - pubmed
Paraoxonase 1 and platelet - activating factor acetylhydrolase activities in patients with low hdl - cholesterol levels with or without primary hypertriglyceridemia . - pubmed
BACKGROUND : Previous studies have shown that high density lipoprotein ( HDL )- deficient states are associated with reduced paraoxonase 1 ( PON1 ) activity . - pubmed
However , HDL reduction caused by primary hypertriglyceridemia has not been fully explored . - pubmed
The aim of the present study was to evaluate whether PON1 and platelet - activating factor acetylhydrolase ( PAF - AH ) , two antioxidant enzymes , were altered in patients with low HDL - cholesterol levels with or without primary hypertriglyceridemia in comparison with control normolipemic subjects . - pubmed
METHODS : We studied 24 patients with low HDL - cholesterol levels with ( n=12 ) or without ( n=12 ) primary hypertriglyceridemia in comparison with 12 control subjects who presented normal HDL - cholesterol and triglyceride levels . - pubmed
PAF - AH activity was not different between hypoalphalipoproteinemic patients and controls . - pubmed
CONCLUSIONS : Data from this study would suggest that in hypoalphalipoproteinemic syndrome , particularly when associated with hypertriglyceridemia , there is impairment in enzymatic antioxidant activity exclusively related with HDL . - pubmed
Lymphotoxin - alpha , CXC ligand ( CXCL ) 12 , and CXCL13 , key mediators of lymphoid neogenesis , were present in the CSF from patients with MS and other inflammatory neurological disorders and were expressed in MS brain tissue , with selective localization in the outer layer of the capillary vessel wall . - pubmed
NKT cells , however , exhibited a strong cytotoxicity when they were activated and expanded with alpha - GalCer plus IL-2 in vitro . - pubmed
These results indicated that NKT cells act as regulatory cells via production of cytokines for activation of NK cell - mediated cytotoxicity in vivo at early phase after alpha - GalCer administration . - pubmed
Potent tumor - specific immunity induced by an in vivo heat shock protein - suicide gene - based tumor vaccine . - pubmed
The combination of HSP70 overexpression in situ and tumor killing by thymidine kinase / ganciclovir treatment , but neither strategy alone , provoked potent systemic antitumor activities after intratumor injection of Ad - HT . - pubmed
Tumor - specific CD4 + and CD8 + T - cell responses were induced by Ad - HT intratumor injection . - pubmed
CD11c+ dendritic cells ( DCs ) isolated from mice treated with Ad - HT were able to prime tumor - specific CTLs . - pubmed
Collectively , these results indicate that the combination of tumor killing by activation of a suicide gene to release tumor antigens and in situ HSP70 overexpression to enhance DC antigen presentation overcomes host immune tolerance to tumor antigens , leading to the induction of potent antitumor immunity . - pubmed
HMMC-1 : a humanized monoclonal antibody with therapeutic potential against Mullerian duct - related carcinomas . - pubmed
RESULTS : HMMC-1 is a human IgM monoclonal antibody that reacts positively with mullerian duct - related carcinomas with positive rates of 54.6 % against uterine endometrial adenocarcinoma , 76.9 % against uterine cervical adenocarcinoma , and 75.0 % against epithelial ovarian cancer . - pubmed
HMMC-1 does not react with normal endometrium at proliferative or secretory phases , normal uterine cervix , or normal and malignant tissue from other organs , whereas it reacts weakly with the epithelium of the gall bladder and the collecting duct of the kidney . - pubmed
The unique specificity and cytotoxicity of HMMC-1 strongly suggest a therapeutic potential of this antibody . - pubmed
Adult children ( n = 149 ) of people with AD were randomized to one of two groups -- Intervention group : lifetime risk estimates of AD based on age , gender , family history , and Apolipoprotein E ( APOE ) genotype ; CONTROL GROUP : lifetime risk estimates of AD based on the same risk factors excluding APOE genotype . - pubmed
New and old functions of STAT3 : a pivotal target for individualized treatment of cancer . - pubmed
Recently , aberrant signaling by STAT proteins has been demonstrated to play important roles in the pathogenesis of many neoplasms , by promoting cell cycle progression and survival , stimulating angiogenesis , and impairing immunological responses and tumor surveillance . - pubmed
We have developed genetic tools to evaluate STAT - dependent malignancy and showed that survival and growth of lymphoid malignancies requires expression of STAT3 . - pubmed
While the tyrosine phosphorylation of STAT3 , which is indicative of its signal - dependent activation , is a common occurrence in tumors , and appears to play a crucial role in some malignancies , a variety of new data suggest that it can be dispensable under some circumstances and STAT3 can participate in transformation through novel and non - canonical mechanisms . - pubmed
Moreover , low doses of a TACI fusion protein ( TACI - Fc ) that express the extracellular domain of TACI ( amino acid [ aa ] 1 - 126 ) restored CTL priming in B - cell - deficient mice in vivo and induced DC maturation in vitro . - pubmed
The role of extracellular signal - regulated protein kinase in transcriptional regulation of the hypoxia marker carbonic anhydrase IX . - pubmed
In the present study , we investigated the role of the extracellular signal - regulated protein kinase ( ERK ) in regulation of the hypoxia marker , carbonic anhydrase IX ( CAIX ) . - pubmed
U0126 , a specific inhibitor of MEK1 / 2 , downregulated CAIX expression induced by true hypoxia and cell density . - pubmed
Mapping of the U0126 effect revealed that both critical elements within the CA9 promoter , the hypoxia response element and the juxtaposed SP1 - binding PR1 , were inhibited . - pubmed
Constitutively increased ERK activity in isogenic fibrosarcoma cell lines did not cause increased cell density - dependent CAIX expression / CA9 promoter activity . - pubmed
A new de novo Notch3 mutation causing CADASIL . - pubmed
Here , we describe a 44 - year - old patient with clinical features of CADASIL who was a carrier of a new Notch3 mutation : cys128 - ->gly . - pubmed
This case illustrates the interest of analysing the Notch3 gene in cases with clinical features of CADASIL , even in the absence of a family history of the disease . - pubmed
Glucose regulation of CDK7 , a putative thiol related gene , in experimental diabetic nephropathy . - pubmed
We previously described the identification of the 3'end of an unknown gene CDK7 using differential display which appeared to be up - regulated in diabetic kidneys [ R.A. - pubmed
In the kidneys of the GK rat , a model of type II diabetes , CDK7 showed a steady age - related increase in mRNA , increasing to & gt;sixfold in 40 week GK rats compared to normoglycemic age - matched Wistar rat kidneys , this increase correlates with progressive hyperglycemia . - pubmed
Obese subjects had a higher prevalence of iron deficiency defined by serum iron ( 24.3 % , confidence intervals ( CI ) 19.3 - 30.2 vs 15.7 % , CI 11.0 - 21.9 % , P=0.03 ) and transferrin receptor ( 26.9 % , CI 21.6 - 33.0 vs 15.7 % , CI 11.0 - 21.9 % , P=0.0078 ) but not by ferritin ( 9.8 % , CI 6.6 - 14.4 vs 9.3 % , CI 5.7 - 14.7 % , P=0.99 ) . - pubmed
The TGFBI A546D mutation causes an atypical type of lattice corneal dystrophy . - pubmed
PURPOSE : To report the clinical , molecular , and histopathological features of a distinct transforming growth factor - beta - induced ( TGFBI ) gene - linked amyloidotic corneal dystrophy exhibiting an unusual lattice pattern . - pubmed
CONCLUSIONS : The lattice phenotype resulting from the TGFBI A546D mutation in this family is distinct from that observed in a previously described pedigree carrying the A546D mutation and exhibiting a phenotype designated " polymorphic corneal amyloidosis " . - pubmed
A pilot study of matrix metalloproteinases on the model of daunorubicin - induced cardiomyopathy in rabbits . - pubmed
In the present study we aimed to assess the role of MMPs in experimental cardiomyopathy induced by repeated 10 - week administration of daunorubicin ( 3 mg / kg i.v . ) - pubmed
In the daunorubicin group , the plasma cardiac troponin T levels ( cTnT - a marker of myocardial necrosis ) were significantly increased ( p<0.05 ) , commencing with the 8th administration compared with the controls . - pubmed
The amount of collagen ( an estimate of fibrosis ) was also significantly higher in the daunorubicin group ( 13.39 + /- 0.97 mg / g wet weight ) compared to the control group ( 10.03 + /- 0.65 mg / g wet weight ) . - pubmed
Trastuzumab is a humanised IgG1 monoclonal antibody , which selectively binds to the human epidermal growth factor receptor 2 ( HER2 ) , inhibiting cell proliferation and survival in HER2 - dependent tumours . - pubmed
In a randomised phase III trial in postmenopausal women with HER2 and hormone receptor ( HR ) co - positive metastatic breast cancer , median progression - free survival ( primary endpoint ) was significantly longer in patients receiving intravenous trastuzumab plus oral anastrozole than in those receiving anastrozole alone . - pubmed
In a noncomparative phase II study of trastuzumab plus letrozole in postmenopausal women with HER2 and HR co - positive metastatic breast cancer , the majority of adverse events were mild or moderate in severity . - pubmed
OBJECTIVE : To investigate the relationship between muscle segment homeobox gene-1 ( MSX1 ) and the genetic susceptibility of nonsyndromic cleft lip and palate ( NSCLP ) in Hunan Hans . - pubmed
CONCLUSIONS : MSX1 gene is associated with NSCLP , and MSX1 gene may be directly involved either in the etiology of NSCLP or in linkage disequilibrium with disease - predisposing sites . - pubmed
AIM : To determine whether endurance training can counterbalance the negative effects of hypoxia on mitochondrial phosphorylation and expression of the long chain mitochondrial fatty acid transporter muscle carnitine palmitoyl transferase 1 ( mCPT-1 ) . - pubmed
RESULTS : Chronic hypoxia decreased basal ( V(0 ) , -31 % with pamitoylCoA + carnitine and -21 % with palmitoylcarnitine , P & lt ; 0.05 ) and maximal ( V(max ) , -31 % with pamitoylCoA + carnitine , P & lt ; 0.05 ) respiration rates , hydroxyacylCoA dehydrogenase activity ( -48 % , P & lt ; 0.05 ) , mCPT-1 activity index ( -34 % , P & lt ; 0.05 ) and mCPT-1 protein content ( -34 % , P & lt ; 0.05 ) . - pubmed
Five weeks of endurance training in hypoxia brought V(0 ) , mCPT-1 activity index and mCPT-1 protein content values back to sedentary normoxic levels . - pubmed
MATERIALS AND METHODS : We compared NMRI and C57Bl/6 mice , a SSRI - sensitive strain , in the tail suspension test following citalopram , paroxetine , or fluoxetine and determined 5 - HT transporter ( 5 - HTT ) densities , 5 - HT tissue and extracellular levels , 5 - HT synthesis , tryptophan hydroxylase 2 ( TPH2 ) genotypes and hypothermia induced by the 5 - HT(1A ) agonist 8 - OH - DPAT . - pubmed
BACKGROUND : Based on the outcome of several randomized controlled trials , the orally active leukotriene receptor antagonist montelukast ( Singulair , Merck ) has been licensed for treatment of asthma . - pubmed
Besides , we found that the 5 ' regions of Dnmt1 and Dnmt2 were nearly completely unmethylated in all normal adults , IVF fetuses , sperm and aborted clones . - pubmed
Association of epidermal growth factor receptor ( EGFR ) gene mutations with EGFR amplification in advanced non - small cell lung cancer . - pubmed
Somatic mutations in the epidermal growth factor receptor ( EGFR ) gene are associated with the response to EGFR tyrosine kinase inhibitors in patients with non - small cell lung cancer ( NSCLC ) . - pubmed
However , given that it is often difficult to obtain sufficient amounts of tumor tissue for genetic analysis from patients with advanced NSCLC , the relationship between these two types of EGFR alterations has remained unclear . - pubmed
We have now evaluated EGFR mutation status both by direct sequencing and with a high - sensitivity assay , the Scorpion - amplification - refractory mutation system , and have determined EGFR copy number by fluorescence in situ hybridization ( FISH ) analysis in paired tumor specimens obtained from 100 consecutive patients with advanced NSCLC treated with chemotherapy . - pubmed
Our results therefore suggest the existence of a significant association between EGFR mutation and EGFR amplification in patients with advanced NSCLC . - pubmed
Assessment of myocardial blood perfusion improved by CD151 in a pig myocardial infarction model . - pubmed
AIM : To appraise the efficacy of CD151 - induced myocardial therapeutic angiogenesis in a pig myocardial infarction model . - pubmed
CONCLUSION : This study demonstrated that the rAAV - mediated CD151 gene delivery promoted efficient neovascularization and increased the blood perfusion after myocardial infarction in pigs . - pubmed
RESULTS : Almost half of smokers who carried a CYP1A1 variant ( 51.3 % ) , GSTT1 null ( 43.6 % ) , or GSTM1 null genotypes ( 64.1 % ) delivered a baby with IUGR . - pubmed
An interaction test showed increased prevalence of IUGR in smokers with the CYP1A1 ( Aa / aa ) variant ( adjusted OR , 1.9 ; 95 % CI , 1.4 - 5.5 , p=0.01 ) , or with the GSTT1 null ( AOR , 1.5 ; 1.1 - 3.1 , p=0.001 ) , or GSTM1 null genotypes ( AOR , 1.5 ; 1.2 - 3.7 , p=0.001 ) . - pubmed
Bioluminescence and Ki67 IHC suggested tumor proliferation within the model . - pubmed
The main effects of training were indicated by increased running time to exhaustion ( 80 + /- 5 and 151 + /- 13 min for groups E and TE , respectively , P = 0.0001 ) , myocardial hypertrophy ( 0.38 % and 0.47 % for untrained and trained rats , respectively , P = 0.0002 ) , decreased LV ejection fraction ( 88 % and 71 % for untrained and trained rats , respectively , P & lt ; 0.0001 ) , accelerated mitochondrial DNA 4834 - bp large deletion ( mtDNA4834 deletion ) , and up - regulated protein levels of heat shock protein-70 , cytochrome C , cleaved capsase-3 , and cleaved PARP in LV following a bout of exhaustive exercise . - pubmed
Oxygen - regulated protein 150 ( ORP150 ) , also known as grp170 , is an endoplasmic reticulum - resident HSP and is up - regulated by hypoxia . - pubmed
A combination of the VP2 and VP3 MAbs could be used to more easily detect TSV infections in field samples of L. - pubmed
Complementary roles in cancer prevention : protease inhibitor makes the cancer preventive peptide lunasin bioavailable . - pubmed
TSLP protein expression was also enhanced by RSV infection . - pubmed
The novel histone deacetylase inhibitor , AR-42 , inhibits gp130 / Stat3 pathway and induces apoptosis and cell cycle arrest in multiple myeloma cells . - pubmed
alpha - Synuclein is known to be involved in pathogenesis of a subset of neurodegenerative diseases collectively known as synucleinopathies . - pubmed
Nephroblastoma overexpressed ( Nov ) induces gremlin in ST-2 stromal cell lines by post - transcriptional mechanisms . - pubmed
Nephroblastoma overexpressed ( Nov ) inhibits osteoblastogenesis in part because it binds bone morphogenetic protein ( BMP )- 2 . - pubmed
Treatment of spleen macrophages or HS - P cells cocultured with ILS with cobalt chloride , which mimics the effects of anemia - induced hypoxia , led to downregulation of M - CSF mRNA levels , upregulation of GM - CSF and MIF , and an increase in phagocytic activity . - pubmed
Estrogen receptor of breast cancer stem cells depending on the original breast cancers . - pubmed
There has been arguments about the estrogen receptor - alpha ( from this point referred to as ER ) of breast cancer stem cells ( BrCSCs ) . - pubmed
We concluded that the ER expression of BrCSCs in ER (+ ) breast cancers is positive , while it is negative in ER (- ) breast cancers . - pubmed
Therefore , we hypothesize that the ER expression of BrCSCs depends on the original breast cancers . - pubmed
Triple - negative breast cancer ( TNBC ) is characterized by lack of hormone receptors and HER-2 and shares many features with BRCA1 - associated cancer . - pubmed
Preclinical data indicate cisplatin sensitivity , suggesting that these tumors may have defects in the BRCA1 pathway . - pubmed
Granulocyte colony - stimulating factor increases the therapeutic efficacy of bone marrow mononuclear cell transplantation in cerebral ischemia in mice . - pubmed
To explore this possibility , the present study examined the effect of BMMCs and G - CSF on cell proliferation , early neuronal development and neurological function recovery in experimental cerebral ischemia relative to controls that received neither treatment . - pubmed
RESULT : Ischemia / infarct area was significantly reduced in BMMCs+G - CSF group relative to animal groups treated with BMMCs only , G - CSF only or saline . - pubmed
The results suggest that G - CSF can increase the therapeutic efficacy of BMMCs transplantation in an experimental mouse model of cerebral ischemia . - pubmed
Heme - regulated eukaryotic initiation factor 2alpha kinase ( HRI ) functions under conditions of heme shortage caused by blood diseases such as erythropoietic protoporphyria and beta - thalassemia , and retains the heme : globin ratio at 1:1 by sensing the heme concentration in reticulocytes . - pubmed
Hepatitis C virus ( HCV ) infected patients with vasculitis are often treated with the B - cell - depleting anti - CD20 antibody rituximab . - pubmed
The 70 - kDa ribosomal protein S6 kinase ( p70S6 K ) is part of the PI3K / AKT / mTOR pathway and has been implicated in cancer . - pubmed
We included 576 subjects ( 229 controls , 193 AD , and 154 mild cognitive impairment subjects who converted to AD ) from the ADNI study , for whom baseline data on cerebrospinal fluid amyloid - beta ( Abeta)42 , phosphorylated tau ( p - tau ) , and total - tau ( t - tau ) , hippocampal volumes , and FDG - PET were available . - pubmed
To ensure the quality of the filter system every 7 days metabolic parametres such as WBC count , haemoglobin content , haemolysis rate , potassium load , pH and ATP content were analysed over a storage period of 49 days . - pubmed
HMGA2 elicits EMT by activating the Wnt / beta - catenin pathway in gastric cancer . - pubmed
BACKGROUND : The high mobility group protein A2 ( HMGA2 ) is an architectural transcription factor that plays an important role in the development and progression of many malignant neoplasms . - pubmed
High expression of HMGA2 in gastric cancer correlates with invasiveness of cancer and is an independent prognostic factor . - pubmed
METHODS : We examined the cell biology and molecular biology changes after overexpression and knockdown HMGA2 of gastric cancer cells in vitro and vivo . - pubmed
To further understand the underlying mechanisms of EMT promoted by HMGA2 , based on our previous study , we examined the changes of target genes of HMGA2 after overexpression and knockdown HMGA2 of gastric cancer cells . - pubmed
CONCLUSIONS : The Wnt / beta - catenin pathway activated by HMGA2 might be the underlying mechanism of EMT in gastric cancer cells . - pubmed
Gene therapy for colorectal cancer by an oncolytic adenovirus that targets loss of the insulin - like growth factor 2 imprinting system . - pubmed
Loss of imprinting ( LOI ) of the insulin - like growth factor 2 ( IGF2 ) gene is an epigenetic abnormality observed in human colorectal neoplasms . - pubmed
Our aim was to investigate the feasibility of using the IGF2 imprinting system for targeted gene therapy of colorectal cancer . - pubmed
Slc26a4 ( Delta / Delta ) mice are deaf , develop an enlarged membranous labyrinth , and thereby largely resemble the human phenotype where mutations of SLC26A4 cause an enlarged vestibular aqueduct and sensorineural hearing loss . - pubmed
The data suggest that the endolymphatic enlargement caused by a loss of Slc26a4 is a consequence of disrupted Na (+ ) transport . - pubmed
Activation of orexin receptors promotes waking and is essential for expression of normal sleep and waking behaviour , with the sleep disorder narcolepsy resulting from the absence of orexin signalling . - pubmed
Diabetes diminishes the portal - systemic collateral vascular response to vasopressin via vasopressin receptor and Galpha proteins regulations in cirrhotic rats . - pubmed
Diabetes diminished the portal - systemic collateral vascular response to AVP in rats with BDL - induced cirrhosis , probably via V2 receptor up - regulation and Galpha proteins down - regulation . - pubmed
The presence of disease - associated prion protein in skeletal muscle of cattle infected with classical bovine spongiform encephalopathy . - pubmed
The aim of this study was to investigate the presence of disease - associated prion protein ( PrP(Sc ) ) in the skeletal muscle of cattle infected with classical bovine spongiform encephalopathy ( C - BSE ) . - pubmed
The present data indicate that small amounts of PrP(Sc ) are detectable by immunohistochemistry in the skeletal muscles of animals terminally affected with C - BSE . - pubmed
Some of these TGs were also associated with estrogen receptor status and overall or disease - free survival of the patients . - pubmed
Development of a highly sensitive and specific blastomycosis antibody enzyme immunoassay using Blastomyces dermatitidis surface protein BAD-1 . - pubmed
Changes in surface expression of N - methyl - D - aspartate receptors in the striatum in a rat model of Parkinson ' s disease . - pubmed
BACKGROUND : N - methyl - D - aspartate ( NMDA ) receptors play a central role in glutamatergic synaptic transmission in the mammalian brain and are linked to the pathophysiology and symptomatology of Parkinson ' s disease ( PD ) . - pubmed
However , changes in NMDA receptor expression in distinct subcellular compartments in PD have not been elucidated . - pubmed
In this study , we investigated changes in subcellular expression of NMDA receptors in striatal neurons in a rodent PD model . - pubmed
RESULTS : In PD rats where 6 - OHDA was selectively lesioned , surface expression of NMDA receptor GluN1 subunits as detected by surface protein crosslinking assays was increased in the striatum . - pubmed
RESULTS : Among 823 hospitalized HIV - positive adults ( median age 40 years , 58 % women ) , 24 % discovered their HIV infection during the hospitalization , median CD4 count was 75 / mm(3 ) ( IQR : 25 - 177 ) and 48 % had previously received antiretroviral treatment ( ART ) . - pubmed
A series of compounds which contain pyrazole , thiazole and naphthalene ring ( 1a-7a , 1b-7b , 1c-7c , 1d-7d ) were firstly synthesized and their anti - proliferative activity , EGFR inhibitory activity , cytotoxicity and inhibition to Hela cell migration were evaluated . - pubmed
Detection of immunoglobulin M ( IgM ) antibodies has long been used as an important diagnostic tool for identifying active viral infections , but their relevance in later stages has not been clearly defined in vivo . - pubmed
In this study , we followed the kinetics , longevity , and function of influenza virus - specific IgM antibodies for 2 years following sublethal infection of mice with live mouse - adapted A / PR / 8 / 34 virus or immunization with formalin - inactivated virus . - pubmed
N -[ 3,4 - dimethoxycinnamoyl ]- anthranilic acid ( tranilast ) inhibits transforming growth factor beta , alleviates allergic reactions , and decreases hypertrophic skin scars . - pubmed
Histological evaluation of ionized calcium binding adaptor molecule 1 ( Iba1 ) at 1 week after SCI and glial fibrillary acidic protein ( GFAP ) , fibronectin , and chondroitin sulfate ( CS ) at week 8 was performed . - pubmed
At week 1 after SCI , inflammatory - cell invasion was more severe and Iba1 expression was significantly higher in the control group . - pubmed
METHODS : Thrombopoiesis was determined by quantification of platelet counts , thrombopoietin , immature platelet fraction , and mean platelet volume during HFRS . - pubmed
RESULTS : The levels of thrombopoietin , immature platelet fraction , and mean platelet volume all indicate increased thrombopoiesis during HFRS . - pubmed
Most interestingly , we observed significantly increased in vivo platelet activation in HFRS patients with intravascular coagulation ( DIC and thromboembolic complications ) as shown by sP - selectin and sGPVI levels . - pubmed
Insulin dependence as an independent predictor of perioperative morbidity after ventral hernia repair : a National Surgical Quality Improvement Program analysis of 45,759 patients . - pubmed
The single amino acid mutation G26R in human apolipoprotein A - I ( apoA - IIowa ) is the first mutation that was associated with familial AApoA1 amyloidosis . - pubmed
The N - terminal fragments ( amino acid residues 1 - 83 ) of apoA - I containing this mutation deposit as amyloid fibrils in patients ' tissues and organs , but the mechanisms of cellular degradation and cytotoxicity have not yet been clarified . - pubmed
The mitochondrial dysfunction caused by apoA - IIowa fibrils depended on cathepsin B and was ameliorated by increasing the degradation of apoA - IIowa fibrils . - pubmed
Our results thus provide evidence that the target of apoA - IIowa fibrils is lysosomes , and we thereby gained a novel insight into the mechanism of AApoA1 amyloidosis . - pubmed
Breast cancer with an extremely high Ki-67 labeling index despite a low nuclear grade . - pubmed
In particular , the presence of citrate was able to increase their cytotoxicity and genotoxicity , exerting also epigenotoxic effects , as evaluated by the marked reduction of LINE-1 methylation levels . - pubmed
OBJECTIVE : Tofacitinib is an oral JAK inhibitor indicated for the treatment of rheumatoid arthritis ( RA ) . - pubmed
Numerically , more lymphoma cases had a history of Sjogren ' s syndrome and were positive for anti - cyclic citrullinated protein and rheumatoid factor at baseline versus matched controls . - pubmed
The DEGs could be classified in four categories : hydrolases ( enzymes involved in various physiological functions , including digestion , immune response , blood coagulation , and reproduction ) , biological binding ( FMN- , actin- and metal ion - binding ) , metabolic enzymes ( e.g. - pubmed
Role for ERK1 / 2 - dependent activation of FCHSD2 in cancer cell - selective regulation of clathrin - mediated endocytosis . - pubmed
We recently reported that signaling can reciprocally regulate CME in cancer cells and that this crosstalk can contribute to cancer progression . - pubmed
To further explore the nature and extent of the crosstalk between signaling and CME in cancer cell biology , we analyzed a panel of oncogenic signaling kinase inhibitors for their effects on CME across a panel of normal and cancerous cells . - pubmed
Inhibition of several kinases selectively affected CME in cancer cells , including inhibition of ERK1 / 2 , which selectively inhibited CME by decreasing the rate of clathrin - coated pit ( CCP ) initiation . - pubmed
Loss of FCHSD2 activity in nonsmall cell lung cancer ( NSCLC ) cells leads to increased cell - surface expression and altered signaling downstream of EGFR , resulting in enhanced cell proliferation and migration . - pubmed
The expression level of FCHSD2 is positively correlated with higher NSCLC patient survival rates , suggesting that FCHSD2 can negatively affect cancer progression . - pubmed
Low back pain resolved and his white blood cell count and C - reactive protein levels remained normal with the combination therapy . - pubmed
Lactate modulates CD4 + T - cell polarization and induces an immunosuppressive environment , which sustains prostate carcinoma progression via TLR8 / miR21 axis . - pubmed
In turn , this metabolic - based CAF - immunomodulated environment exerts a pro - invasive effect on prostate cancer cells , by activating a previously unexplored miR21 / TLR8 axis that sustains cancer malignancy . - pubmed
Potential involvement of S1PR1 / STAT3 signaling pathway in cardiac valve damage due to rheumatic heart disease . - pubmed
Th17 cell - associated cytokines might play a role in the pathogenesis and development of RHD , but the specific molecular mechanism is not completely understood . - pubmed
We investigated the potential role of sphingosine-1 - phosphate receptor 1 ( S1PR1)/signal transducer and activator of transcription 3 ( STAT3 ) signaling pathway in cardiac valve damage in a rat model of RHD . - pubmed
The S1PR1 / STAT3 signaling pathway was activated in the RHD model . - pubmed
Compared to the control group , serum levels of IL-17 and IL-21 cytokines associated with Th17 cells were increased significantly in the RHD group ; the collagen volume fraction also was substantially increased . - pubmed
The S1PR1 / STAT3 signaling pathway might be involved in RHD induced cardiac valve damage by regulating Th17 cells . - pubmed
Identification of two clip domain serine proteases involved in the pea aphid 's defense against bacterial and fungal infection . - pubmed
Phenoloxidases ( POs ) are required for the pea aphid 's defense against bacterial and fungal infection . - pubmed
Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer . - pubmed
In addition to its implication in hereditary hearing loss , the Gasdermin E ( GSDME ) gene is also a tumor suppressor involved in cancer progression through programmed cell death . - pubmed
GSDME epigenetic silencing through methylation has been shown in some cancer types , but studies are yet to fully explore its diagnostic / prognostic potential in colorectal cancer on a large - scale . - pubmed
We used public data from The Cancer Genome Atlas ( TCGA ) to investigate differences in GSDME methylation and expression between colorectal cancer and normal colorectal tissue , and between left- and right - sided colorectal cancers in 432 samples . - pubmed
We also explored GSDME 's diagnostic capacity as a biomarker for colorectal cancer . - pubmed
We observed differential methylation in all 22 GSDME CpGs between tumor and normal tissues , and in 18 CpGs between the left- and right - sided groups . - pubmed
Our results suggest that GSDME is a promising biomarker for the detection of colorectal cancer . - pubmed
Expression levels of paraoxonase-1 in aortic valve tissue are associated with the progression of calcific aortic valve stenosis . - pubmed
Background : Paraoxonase-1 ( PON1 ) participates in several vital steps of lipid metabolism , which is associated with calcific aortic valve stenosis ( CAVS ) . - pubmed
Although a few studies have suggested that PON1 in blood could inhibit aortic valve calcification , they did not provide detailed descriptions . - pubmed
In this study , we hypothesized that PON1 is expressed in the aortic valve and that the PON1 level is related to the severity of CAVS . - pubmed
Conclusions : We detected PON1 in the aortic valve for the first time , and our results suggest that the PON1 level in aortic valve tissue decreases with increasing severity of aortic valve stenosis . - pubmed
Aim : CX1003 is a novel multitargeted receptor tyrosine kinase inhibitor targeting cancer patients with relapsed or metastatic malignant solid tumors . - pubmed
Furthermore , the antioxidant activity , phospholipase A2 - V and cyclooxygenases inhibitory activities of the target compounds 7a&b were evaluated and the new compounds showed potent activity ( cytotoxicity IC50 range from 4.3 to 9.2 microm , antioxidant activity from 40 % to 80 % , COXs or LOX inhibitory activity from 1.92 microM to 8.21 microM ) . - pubmed
Mitochondrial angiotensin II receptors regulate oxygen consumption in kidney mitochondria from healthy and type 1 diabetic rats . - pubmed
Exaggerated activation of the renin angiotensin aldosterone system ( RAAS ) is a key feature in diseases such as hypertension , diabetes and chronic kidney disease . - pubmed
Diabetes is associated with both mitochondrial dysfunction and increased intracellular Ang II concentration in the kidney cortex . - pubmed
The present study investigated the role of Ang II signaling in kidney cortex mitochondria isolated from control and streptozotocin - induced diabetic rats . - pubmed
Ang II binds to only mitochondrial AT2 receptors in control rats and both AT1 receptors and AT2 receptors in diabetic rats . - pubmed
Ang II decreased oxygen consumption in mitochondria from both control and diabetic rats . - pubmed
AT1 receptor inhibition did not affect the response to Ang II , whereas AT2 receptor inhibition abolished the response in mitochondria from control animals and reversed the response to increased oxygen consumption through superoxide - induced mitochondrial uncoupling in mitochondria from diabetic rat . - pubmed
Ang II decrease mitochondrial respiration via AT2 receptor - mediated nitric oxide release in both control and diabetic rats . - pubmed
AT1 receptors do not regulate mitochondria function in control rats , whereas Ang II via AT1 receptors increase mitochondria leak - respiration in diabetic animals . - pubmed
Many previous studies have focused on the abnormal reactions of monocytes / macrophages , neutrophils , complement system , or cytokine inflammation in sepsis . - pubmed
Ribociclib ( LEE011 , Kisqali ) is a highly selective small molecule inhibitor of cyclin - dependent kinases 4 and 6 ( CDK4 / 6 ) , which has been approved for the treatment of advanced or metastatic breast cancer . - pubmed
In the fasted and diabetic rats phosphatase activity was less than one - half of that in fed animals . - pubmed
In diabetic animals insulin also stimulated an increase in synthase phosphatase activity but 30 min were required for full activation . - pubmed
FOCMA is expressed on both T and B lymphoid leukemia cells , but not expressed on non - malignant lymphoid cells , even when they are infected with FeLV . - pubmed
About one - third of the naturally occurring lymphoid tumors of cats lack detectable FeLV proteins and varying portions of the FeLV provirus . - pubmed
Platelet - aggregating factor in thrombotic thrombopenic purpura plasma . - pubmed
Anti - D treatment in thrombocytopenia refractory to conventional therapies . - pubmed
We studied the cell morphology and myeloperoxidase expression of this cell line , which was established from a patient with myelodysplastic syndrome who had an abnormal chromosome on the upstream region of 17p13 . - pubmed
The results of treatment with thyrotropin - releasing hormone ( TRH ) , naloxone and dexamethasone treatments albino rats with experimental spinal cord injury were compared . - pubmed
T - cell reactivity to 38 kD insulin - secretory - granule protein in patients with recent - onset type 1 diabetes . - pubmed
To see whether this reactivity is widespread at disease onset , we have generated T - cell lines in vitro from peripheral blood mononuclear cells of nineteen children of caucasoid origin with newly diagnosed type 1 diabetes and sixteen healthy controls matched for age and HLA antigens . - pubmed
Reactivity towards the 38 kD fraction of insulin - secretory - granule membranes was found only in patients ( eight of ten responders tested ; 95 % CI 44 - 98 % ) and one ICA - positive non - diabetic subject . - pubmed
These data suggest that release of IL-6 and TNF - alpha may regulate lymphocyte proliferation in HTLV - I / II - infected individuals . - pubmed
Immunochemical characterization of circulating parathyroid hormone - related protein in patients with humoral hypercalcemia of cancer . - pubmed
Tumors from patients with humoral hypercalcemia of cancer produce a parathyroid hormone - related protein ( PTHRP ) . - pubmed
Patients with humoral hypercalcemia of cancer ( n = 30 ) had elevated levels of both PTHRP ( 1 to 74 ) ( mean , 20.9 pmol per liter ) and PTHRP ( 109 to 138 ) ( mean , 23.9 pmol per liter ) . - pubmed
The plasma concentrations of immunoreactive PTHRP correlated with the levels of urinary cyclic AMP excreted ; in some patients , the concentrations decreased after the tumors were resected . - pubmed
Patients with chronic renal failure ( n = 15 ) had plasma PTHRP ( 1 to 74 ) concentrations similar to those in the normal subjects , but their plasma PTHRP ( 109 to 138 ) concentrations were elevated ( mean , 29.6 pmol per liter ) . - pubmed
We conclude that plasma PTHRP concentrations are high in the majority of patients with cancer - associated hypercalcemia and that the circulating forms of PTHRP in such patients include both a large N - terminal ( 1 to 74 ) peptide and a C - terminal ( 109 to 138 ) peptide . - pubmed
Measuring the concentrations of PTHRPs may be useful in the differential diagnosis of hypercalcemia . - pubmed
Dex prevented the conjunctival hyperemia , vascular injection and iritis seen with endotoxin treatment alone and blocked the induction of SOD . - pubmed
A similar medrysone ( med ) application ( n = 4 ) failed to prevent the visible signs of ocular inflammation yet also blocked the elevation of SOD . - pubmed
The data indicate that a product of the lipoxygenase pathway may be mediating the induction of SOD seen with endotoxin - induced ocular inflammation . - pubmed
To test this hypothesis , we tested the tensile strength of femora from normal rats and from untreated and insulin - treated diabetic rats two weeks after the production of a closed fracture . - pubmed
Treatment of the diabetic animals with insulin resulted in a mean concentration of serum glucose of 14.4 + /- 0.6 millimoles per liter ( 260 + /- 10 milligrams per deciliter ) and restored the tensile strength and stiffness of the callus to a value that was not statistically different from that of the controls . - pubmed
Between the fourth and eleventh days of healing , there was a 50 to 55 per cent decrease in the collagen content of the callus of the untreated diabetic animals compared with the controls . - pubmed
Between the fourth and eleventh days of healing , the collagen - to - DNA ratio , which was determined as an indicator of net collagen synthesis per cell , was decreased 15 to 50 per cent in callus from the untreated diabetic animals . - pubmed
The effects of Mg2 + ions or EDTA on nuclear integrity and apparent subcellular distribution of unoccupied oestrogen receptors in breast cancer cells . - pubmed
Lactate dehydrogenase isoenzymes in leprosy patients on multi drug therapy -- a preliminary report . - pubmed
Serum LDH ( total ) and LDH isoenzymes were studied in leprosy patients undergoing multidrug treatment . - pubmed
Serum LDH ( total ) did not show any significant difference between normal human subjects and patients but LDH isoenzymes have shown elevated levels in LDH4 and LDH5 in leprosy patients . - pubmed
The effects of an aromatase inhibitor and a 5 alpha - reductase inhibitor upon the occurrence of polyovular follicles , persistent anovulation , and permanent vaginal stratification in mice treated neonatally with testosterone . - pubmed
In order to demonstrate a suspected complement activation in bronchial asthma , we measured the C3d ( split product of C3 ) and the C3d / C3 ratio in 73 adults . - pubmed
Compared with the value obtained in 47 normal subjects , the C3d level and the C3d / C3 ratio level were found significantly higher in asthmatic subjects . - pubmed
Fourteen asthmatics presented an increased C3d / C3 above the calculated limit of normality . - pubmed
These 14 subjects differed from the other asthmatics by a significantly lower C4 plasmatic level , suggesting an activation of the classical pathway of the complement system . - pubmed
Nevertheless , the clinical significance of these observations remains difficult to interpret in view of the absence of significant differences of clinical , allergologic and respiratory functional parameters between asthmatics with low or high C3d / C3 index . - pubmed
Antibodies to the 4 - mer repeat of the ring - infected erythrocyte surface antigen ( Pf155 / RESA ) protect against Plasmodium falciparum malaria . - pubmed
To investigate the protective role of antibodies to the ring - infected erythrocyte surface antigen ( Pf155 / RESA ) epitopes against Plasmodium falciparum clinical malaria , a cohort study was conducted in a Malagasy village over 7 months . - pubmed
Because epidermal growth factor ( EGF ) , transforming growth factor - alpha ( TGF - alpha ) , and epidermal growth factor receptor ( EGFR ) have been implicated in the regulation of adrenocortical function , we used immunohistochemistry and in situ hybridization of EGF and TGF - alpha to study 41 specimens of human adrenal cortex , including 10 normal specimens , 15 aldosteronomas , five Cushing ' s adenomas , six adrenocortical incidentalomas , and five carcinomas to determine what role these growth factors play in controlling human adrenocortical function . - pubmed
TGF - alpha expression was observed in the cells with increased steroidogenesis , including compact tumor cells and zona fasciculata cells with lipid depletion , but did not necessarily correlate with production sites of any specific steroid hormone . - pubmed
Both TGF - alpha and EGFR expression were markedly elevated in adrenocortical carcinomas . - pubmed
In addition , TGF - alpha and EGFR may play important roles in some biological features of adrenocortical malignancy . - pubmed
The effect of a short treatment ( 7 days ) with the reversible monoamine oxidase type A inhibitor toloxatone on the reactivity to the inhalation of 35 % CO2 was evaluated in 18 panic patients who responded to 35 % CO2 inhalation with panic before treatment . - pubmed
It may be concluded that NMDA receptor blockade results in enhanced anticonvulsive action of common antiepileptics against maximal electroshock - induced seizures . - pubmed
Deficiency of glucose-6 - phosphate dehydrogenase ( G6PD ) is usually found at high frequencies in areas of the world where malaria has been endemic . - pubmed
To determine the extent of heterogeneity of G6PD , we have studied several different Indian populations by screening for G6PD deficiency , followed by molecular analysis of deficient alleles . - pubmed
Remarkably , a previously unreported deficient variant , G6PD Orissa ( 44 Ala-->Gly ) , is responsible for most of the G6PD deficiency in tribal Indian populations but is not found in urban populations , where most of the G6PD deficiency is due to the G6PD Mediterranean ( 188 Ser-->Phe ) variant . - pubmed
Granulocyte colony - stimulating factor recruitment of CD34 + progenitors to peripheral blood : impaired mobilization in chronic granulomatous disease and adenosine deaminase -- deficient severe combined immunodeficiency disease patients . - pubmed
Peripheral blood ( PB ) CD34 + cells mobilized by granulocyte colony - stimulating factor ( G - CSF ) administration are potentially useful for transplantation and as a target of gene transfer for therapy of hematopoietic disorders . - pubmed
We used this assay to assess the kinetics of G - CSF - mediated mobilization of CD34 + cells to PB in normal volunteers and in patients with chronic granulomatous disease ( CGD ) or adenosine deaminase ( ADA )- deficient severe combined immunodeficiency disease ( SCID ) . - pubmed
With 32 normal volunteers mean peak CD34 + cell counts were 57 and 76 cells / mm2 of blood ( 5 and 10 micrograms doses , respectively ) , whereas for 18 CGD patients the mean peaks were 31 and 40 cells / mm2 of blood . - pubmed
For 2 ADA - deficient SCID patients studied at a G - CSF dose of 5 micrograms / kg / d , the average peak was 16 cells / mm2 of blood . - pubmed
At days 5 and 6 ( peak mobilization of CD34 + cells ) the mean ANC of CGD and ADA patients was only slightly lower ( & lt ; or = 15 % ) than that seen with normal subjects , whereas the difference in CD34 + cell mobilization was & gt ; 48 % . - pubmed
Finally , unexpected , but significant differences in the PB CD34 + cell mobilization between normal subjects and patients with inherited disorders can occur and underscores the importance of establishing the expected mobilization of PB CD34 + cells in the planning of treatment approaches using these cells . - pubmed
Although the higher MK-801 dose reduced seizure duration by 50 % , the ECS induced NPY - LI increase in striatum , occipital cortex and hippocampus , and NKA - LI in occipital cortex was not diminished . - pubmed
In contrast , there was a parallel decrease in seizures and NPY - LI and NKA - LI changes in frontal cortex and hippocampus , respectively . - pubmed
Using this design , in a single diagnostic assay , we tested samples for 66 cystic fibrosis ( CF ) mutations , 14 beta - thalassemia mutations , two sickle cell anemia ( SCA ) mutations , three Tay - Sachs mutations , eight Gaucher mutations , four mutations in Canavan disease , four mutations in Fanconi anemia , and five mutations in BRCA1 . - pubmed
Thus , therapy targeting TNF and/or its p55 receptor presents itself as a means of preventing the osteolysis of chronic bacterial infection . - pubmed
Bacteria and viruses produce exogenous SAgs and those related to food poisoning have been widely studied . - pubmed
The presence of parasite SAgs is still unclear and further studies are required to establish their existence and effects on the corresponding infections . - pubmed
Progesterone and transforming growth factor - beta coordinately regulate suppression of endometrial matrix metalloproteinases in a model of experimental endometriosis . - pubmed
Matrix metalloproteinases ( MMPs ) , enzymes which are important for extracellular matrix turnover , have recently been implicated in the development of endometriosis . - pubmed
Intriguingly , although transforming growth factor - beta ( TGF - beta ) mediates progesterone suppression of specific endometrial MMPs , this growth factor is overexpressed in women with endometriosis . - pubmed
In the current study , we used an established experimental model of endometriosis to explore MMP regulation by TGF - beta . - pubmed
Our findings indicate that blocking the action of TGF - beta opposes progesterone - mediated suppression of MMPs and blocks the ability of this steroid to prevent experimental endometriosis . - pubmed
Taken together , our data suggest that in the absence of a normal progesterone response , common in ectopic lesions of endometriosis , sensitivity to TGF - beta may be altered , resulting in a failure to regulate MMPs . - pubmed
TNF receptor 1 ( TNFR1 ) and CD95 are not required for T cell deletion after virus infection but contribute to peptide - induced deletion under limited conditions . - pubmed
We showed that TNFR1 and CD95 do not contribute to the decline of antigen - specific cytotoxic T lymphocytes after virus infection . - pubmed
These data indicate that TNFR1 and CD95 are dispensable for deletion of antigen - specific T cells after viral infection . - pubmed
Dihydropyrimidine dehydrogenase activity in human pancreatic tumor tissues . - pubmed
Dihydropyrimidine dehydrogenase ( DPD ) activity was investigated using pancreatic tumors and normal pancreatic tissues surrounding the tumors obtained from 12 patients with pancreatic cancer . - pubmed
The mean DPD activity ( + /- SD ) was 2.69 + /- 1.88 nmol / mg protein / hr in normal pancreatic tissue and was 6.59 + /- 5.36 nmol / mg protein / hr in pancreatic tumor tissues . - pubmed
The DPD activity in tumor tissue was two- to threefold higher ( p & lt ; 0.01 ) than that in normal tissue , but no marked difference was observed in DPD activity among cancer stages . - pubmed
The DPD activity of pancreatic tumors may be a useful clinical marker of the responsibility of fluorinated pyrimidine dosing in pancreatic cancer . - pubmed
Initial studies indicate that the BMPs have neuro , cardio and reno - protective actions and it is likely that therapeutic indications for their use will extend well beyond skeletal disease and injury . - pubmed
Splice site mutation in the type VII collagen gene ( COL7A1 ) in a Taiwanese family with recessive dystrophic epidermolysis bullosa . - pubmed
The purpose of this study was to identify mutations in COL7A1 in one Taiwanese pedigree with generalized RDEB . - pubmed
Galectin-3 and carcinoembryonic antigen expression in medullary thyroid carcinoma : possible relation to tumour progression . - pubmed
We analysed the expression and coexpression of galectin-3 and carcinoembryonic antigen ( CEA ) , one of the putative galectin-3 ligands , in medullary thyroid carcinoma ( MTC ) . - pubmed
CEA expression was found in all tumours , distributed predominantly in the cytoplasm and occasionally at the cell surface . - pubmed
More intense staining for galectin-3 was mainly associated with MTC cases involving lymph node metastases . - pubmed
Eight out of these 10 cases showed moderate to strong galectin-3 expression concomitant with CEA expression throughout the tumour tissue . - pubmed
CONCLUSIONS : These findings suggest that galectin-3 might play a role in the pathobiology of MTC . - pubmed
Simultaneous expression of galectin-3 and CEA in the same tumour cells at an advanced stage of MTC indicates the possibility of their autocrine cooperation during tumour progression . - pubmed
Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy . - pubmed
In the present study , we assessed tau protein levels in cerebrospinal fluids by sandwich ELISA to distinguish CBD from PSP . - pubmed
The assay of CSF tau provided diagnostic sensitivity of 81.5 % and specificity of 80.0 % between CBD and PSP according to receiver - operating characteristic ( ROC ) curve analysis . - pubmed
Using data obtained from a larger number of disease cases , we confirmed our previous findings that tau protein levels in cerebrospinal fluids in patients with CBD are significantly higher than those in patients with PSP . - pubmed
Because tau protein levels in cerebrospinal fluids are significantly higher in early CBD cases than in early PSP cases , measurement of tau protein levels in cerberospinal fluids may be useful for the differential diagnosis of early CBD from early PSP . - pubmed
Murine dlg is the homologue of the Drosophila dlg tumor suppressor gene . - pubmed
The loss of dlg function in Drosophila disrupts cellular growth control , apicobasal polarity , and cell adhesion of imaginal disc epithelial cells , resulting in embryonic lethality . - pubmed
Mice homozygous for the dlg mutation exhibit growth retardation in utero , have hypoplasia of the premaxilla and mandible , have a cleft secondary palate , and die perinatally . - pubmed
OBJECTIVES : To investigate the role substance P ( SP ) plays in prostatic inflammation , we evaluated SP immunoreactivity within the spinal cord after irritation of the prostate . - pubmed
Because alpha - adrenergic blockade attenuates nociceptor - induced pain , the effects of an alpha - adrenergic blocker on SP immunoreactivity were also evaluated . - pubmed
In dementia , the existence of a common predisposing genetic factor ( apolipoprotein E ) has already raised complex issues such as the appropriateness of genetic testing in specific clinical situations -- issues that neurologists will confront more in the future . - pubmed
Genetic polymorphisms of the N - acetyltransferase genes and risk of Parkinson ' s disease . - pubmed
Recently , the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N - acetyltransferase genes , NAT1 and NAT2 . - pubmed
The authors examined NAT1 and NAT2 for association with PD using family - based association methods and single nucleotide polymorphisms ( SNPs ) . - pubmed
The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype ( N = 397 families , 1,580 individuals ) . - pubmed
At 3 months , she developed hypocalcemia and hyperphosphatemia with normal levels of vitamin D and alkaline phosphatase , and parathyroid hormone level was low . - pubmed
FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells . - pubmed
The FLT3 receptor tyrosine kinase is highly expressed in most acute leukemias and frequently mutated in acute myeloid leukemia ( AML ) . - pubmed
The mutated form of the receptor is constitutively activated and known to play an important role in AML , but the activation state of the overexpressed wild - type ( wt ) receptor is , at present , unknown . - pubmed
Coexpression of FL with FLT3 was a universal finding in both primary AML samples and leukemic - derived cell lines . - pubmed
Taken together , these findings represent strong evidence that wtFLT3 is often constitutively activated in AML and thus , like its mutated form , might contribute to the altered signaling that characterizes leukemogenesis . - pubmed
The role of Ca ( 2 + ) ions in tubular toxicity and the effect of calcium channel blockers on CsA toxicity were evaluated by measuring intracellular calcium using the fluorescent dye Fura-2 AM . - pubmed
Differential caspase expression in monocytes after infection may contribute to M. - pubmed
, pigment epithelium - derived growth factor , PEDF ) , which may occur under ischemic conditions , may initiate the process of retinal or choroidal neovascularization , representing a major threat to the eyesight . - pubmed
[ Insulin pump treatment in children and adolescents with type 1 diabetes ] . - pubmed
NO-1886 ( ibrolipim ) , a lipoprotein lipase activator , increases the expression of uncoupling protein 3 in skeletal muscle and suppresses fat accumulation in high - fat diet - induced obesity in rats . - pubmed
Although the lipoprotein lipase ( LPL ) activator NO-1886 shows antiobesity effects in high - fat - induced obese animals , the mechanism remains unclear . - pubmed
Kidney disease after transplantation of a nonrenal organ has been described to be the result of the nephrotoxicity from the commonly used calcineurin - inhibitors as well as other factors . - pubmed
We previously reported cloning of the Taenia solium annexin B1 gene from a metacestode cDNA expression library and demonstrated that it acts as a protective antigen for effective vaccine development against cysticercosis . - pubmed
Undercoding of diagnosis was abundant in patients receiving insulin prescriptions , as a diagnosis of diabetes was often missing . - pubmed
Thiazide diuretics remain primary first - step agents , especially for uncomplicated hypertension ; calcium channel blockers are also efficacious . - pubmed
The secretory phospholipase A2 group IIA : a missing link between inflammation , activated renin - angiotensin system , and atherogenesis ? - pubmed
Inflammation , lipid peroxidation and chronic activation of the renin - angiotensin system ( RAS ) are hallmarks of the development of atherosclerosis . - pubmed
Furthermore , sPLA ( 2 )- IIA is not only a mediator for localized inflammation but may be also used as an independent predictor of adverse outcomes in patients with stable coronary artery disease or acute coronary syndromes . - pubmed
The role of sPLA ( 2 )- IIA in the perpetuation of atherosclerosis appears to be the missing link between inflammation , activated RAS and lipid peroxidation . - pubmed
Plasma adiponectin levels in chronic kidney disease patients : relation with molecular inflammatory profile and metabolic status . - pubmed
BACKGROUND AND AIM : Adiponectin ( ADPN ) exerts anti - inflammatory and cardio protective effects and is associated with decreased cardiovascular risk , however its role in patients with chronic kidney disease is unclear . - pubmed
METHODS AND RESULTS : We investigated the correlation between plasma ADPN levels , the progression of CVD and CKD and the inflammatory gene expression profile of peripheral blood mononuclear cells in patients from the NephroPLIC study ( a prospective study aimed at addressing the progression of cardiovascular damage in relation to kidney dysfunction ) . - pubmed
CONCLUSION : In CKD patients who are not in dialysis ADPN plasma levels are associated with a reduced renal excretory function , but correlate inversely with the determinants of the metabolic syndrome such as glucose , triglycerides and BMI , and directly with HDL . - pubmed
Furthermore , in patients with a similar degree of renal impairment , ADPN plasma levels are associated with a better cardiometabolic profile , despite no significant difference being observed in the gene expression pattern of PBMC . - pubmed
Association of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients . - pubmed
We investigated the effect of the -278A>C polymorphism in the CYP7A1 gene on the response of plasma lipids to a reduced - fat diet for 6 to 8 weeks in a group of 82 dyslipidemic males with a mean age of 46.0 + /- 11.7 years . - pubmed
Individuals who presented at least one high alteration in total cholesterol , low - density lipoprotein cholesterol or triglyceride values were considered to be dyslipidemic . - pubmed
The present study provides evidence that -278A>C polymorphism in the CYP7A1 gene can modify triglyceride concentrations in response to a reduced fat diet in a dyslipidemic male population . - pubmed
This very effective model resulted with eradication of endemic goiter in schoolchildren 6 - 12 - years - old , decrease of prevalence of goiter in adults and pregnant women decrease of frequency of the elevated TSH concentration in neonates blood and decrease of dynamic of increasing an incidence rate of differentiated thyroid cancer and its follicular fraction . - pubmed
Effects of donepezil on amyloid - beta and synapse density in the Tg2576 mouse model of Alzheimer ' s disease . - pubmed
Donepezil , an acetylcholinesterase inhibitor , is an approved drug for the treatment of Alzheimer ' s disease ( AD ) . - pubmed
These results suggest that a higher dose of donepezil may have a measurable impact on tissue level of Abeta protein and plaque deposition and may prevent synapse loss in the Tg2576 mouse model of AD . - pubmed
Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity : Differential contribution of p300 and CBP to Rubinstein - Taybi syndrome etiology . - pubmed
A majority of the individuals diagnosed with RSTS carry heterozygous mutation in the gene CREBBP , but a small percentage of cases are caused by mutations in EP300 . - pubmed
To investigate the contribution of p300 to RSTS pathoetiology , we carried out a comprehensive and multidisciplinary characterization of p300(+/- ) mice . - pubmed
These analyses demonstrate that p300(+/- ) mice exhibit phenotypes that are reminiscent of neurological traits observed in RSTS patients , but their comparison with previous studies on CBP deficient strains also indicates that , in agreement with the most recent findings in human patients , the activity of p300 in cognition is likely less relevant or more susceptible to compensation than the activity of CBP . - pubmed
DNA methylation status of the IL8 gene promoter in aggressive periodontitis . - pubmed
BACKGROUND : Studies evaluating the methylation status of cytokine genes may have relevance for inflammatory diseases in which the expression of some cytokines is altered , such as periodontitis . - pubmed
Tuberous sclerosis , caused by germline mutations in the TSC1 or TSC2 genes , is associated with aberrant upregulation of the mammalian target of rapamycin ( mTOR ) signalling pathway , resulting in growth of tumours , including renal angiomyolipomas ( AMLs ) . - pubmed
More recently , mTOR inhibitors have been used as molecularly targeted treatment to treat AMLs . - pubmed
Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients . - pubmed
Here , we describe studies of dynamin PH domain mutations found in centronuclear myopathy ( CNM ) that increase dynamin 's GTPase activity without altering phosphoinositide binding . - pubmed
Clinical significance of serum anti - annexin V antibodies in Egyptian patients with scleroderma . - pubmed
We investigated the prevalence of anti - annexin V IgG and IgM antibodies in sera of scleroderma patients and their relation to the presence of other antibodies and development of disease morbidity . - pubmed
Sera of 40 scleroderma patients and 15 healthy controls were examined for IgG and IgM anti - annexin V antibodies by ELISA and anticentromere antibodies by indirect immunofluorescence . - pubmed
Serum level of anti - annexin V IgG antibodies in scleroderma patients was significantly higher than that of the control ( P & lt ; 0.001 ) and correlated significantly with the presence of digital ischemia ( P = 0.023 ) and pulmonary fibrosis ( P = 0.02 ) . - pubmed
In conclusion , measurement of serum anti - annexin V IgG antibodies in scleroderma patients may be important for early diagnosis of vascular and pulmonary complications . - pubmed
Efficacy of L - asparaginase with methotrexate and dexamethasone ( AspaMetDex regimen ) in patients with refractory or relapsing extranodal NK / T - cell lymphoma , a phase 2 study . - pubmed
Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis . - pubmed
RESULTS : Sirolimus and everolimus decreased fibrosis up to 70 % , improved portal pressure , reduced ascites , and showed potent down - regulation of pro - fibrogenic genes , paralleled by a strong increase in matrix degradation ( collagenase ) activity ; in contrast , tacrolimus and cyclosporine A had no or even aggravating effects on liver fibrosis in rats . - pubmed
CONCLUSIONS : mTOR inhibition by sirolimus and everolimus in experimental liver fibrosis associates with significantly less fibrosis progression and portal hypertension than treatment with calcineurin inhibitors tacrolimus and cyclosporine A. - pubmed
OBJECTIVES : We examined the relationship between glycosylated hemoglobin ( HbA1c ) level and coronary flow rate in patients with type 2 diabetes mellitus ( DM ) and angiographically normal coronary arteries . - pubmed
The incidence of SCF was significantly greater in patients with HbA1c & gt;=7.0 % than those with HbA1c & lt;7.0 % ( 96.4 % vs. 61.5 % ; p=0.004 ) . - pubmed
Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis . - pubmed
IHC analyses and mouse study also revealed an association between TLN1 overexpression and advanced OSCC with invasion to adjacent tissues . - pubmed
The present study suggests an important role for TLN1 in oral cancer development . - pubmed
TLN1 overexpression could serve as a diagnostic marker for aggressive phenotypes and a potential target for treating OSCC . - pubmed
STIM and Orai in hemostasis and thrombosis . - pubmed
Doxycycline stabilizes vulnerable plaque via inhibiting matrix metalloproteinases and attenuating inflammation in rabbits . - pubmed
Enhanced matrix metalloproteinases ( MMPs ) activity is implicated in the process of atherosclerotic plaque instability . - pubmed
We hypothesized that doxycycline , a broad MMPs inhibitor , was as effective as simvastatin in reducing the incidence of plaque disruption . - pubmed
The results showed that oral administration of doxycycline resulted in a significant increase in the thickness of the fibrous cap of the aortic plaque whereas there was a substantial reduction of MMPs expression , local and systemic inflammation , and aortic plaque vulnerability . - pubmed
In conclusion , doxycycline at a common antimicrobial dose stabilizes atherosclerotic lesions via inhibiting matrix metalloproteinases and attenuating inflammation in a rabbit model of vulnerable plaque . - pubmed
Therapeutic effect of ghrelin in experimental autoimmune encephalomyelitis by inhibiting antigen - specific Th1 / Th17 responses and inducing regulatory T cells . - pubmed
A short systemic treatment with ghrelin after the disease onset reduced clinical severity and incidence of both forms of EAE , which was associated with a decrease in inflammatory infiltrates in spinal cord and in the subsequent demyelination . - pubmed
Elevated circulating cytotoxic T lymphocyte - associated antigen-4 levels are related to lung function and inflammation in chronic obstructive pulmonary disease . - pubmed
The present study aimed to investigate the association between CTLA-4 and COPD . - pubmed
Data revealed that serum levels of CTLA-4 were elevated in COPD patients , inversely correlated with lung function and positively correlated with serum C - reactive protein levels in the COPD group . - pubmed
These findings suggest that CTLA-4 may play a role in COPD . - pubmed
Our results indicated that 11 ( 10 % ) patients experienced incidents of hypoglycaemia ranging from 1.8 to 3.9 mmol / l. None of the individuals affected had received intravenous or subcutaneous insulin . - pubmed
Together these results suggest that re - activation of p53 may be a possible means for eradicating extrachromosomal HPV16 , 18 or 31 genomes in the context of persistent infections . - pubmed
In contrast to geriatric scales , we found history of cardiovascular diseases to be strongly associated for this parameter as for high IL-6 production upon ex vivo stimulation with alum . - pubmed
CHARGE syndrome is a complex genetic syndrome , owing to the wide range of tissues / systems affected by mutations in the CHD7 gene . - pubmed
OBJECTIVES : The aim of this study was to evaluate the efficacy and safety of rituximab and tocilizumab compared with adalimumab , etanercept , and infliximab , in patients with rheumatoid arthritis not responding to first - line treatment , and to compare the efficacy and safety of rituximab versus tocilizumab in patients not responding to anti - tumor necrosis factor alpha ( anti - TNF ) therapy . - pubmed
KRAS mutation testing of tumours in adults with metastatic colorectal cancer : a systematic review and cost - effectiveness analysis . - pubmed
Kirsten rat sarcoma viral oncogene ( KRAS ) mutations make some tumours less responsive to treatment with biological therapies such as cetuximab . - pubmed
OBJECTIVES : To compare the performance and cost - effectiveness of KRAS mutation tests in differentiating adults with metastatic colorectal cancer whose metastases are confined to the liver and are unresectable and who may benefit from first - line treatment with cetuximab in combination with standard chemotherapy from those who should receive standard chemotherapy alone . - pubmed
Four RCTs provided data on the clinical effectiveness of cetuximab plus standard chemotherapy compared with that of standard chemotherapy in patients with KRAS wild - type tumours . - pubmed
METHODS : Anti - Saccharomyces cerevisiae antibody immunoglobulin ( Ig ) A and immunoglobulin G titres , paediatric Crohn ' s disease activity index ( PCDAI ) , serum albumin and C - reactive protein ( CRP ) were repeatedly measured simultaneously in children with Crohn ' s disease . - pubmed
RESULTS : Serial 136 measurements of ASCA IgA and IgG titres were documented in 57 children with Crohn ' s disease over a mean duration of 3.1 + - 2.1 years . - pubmed
CONCLUSION : Both ASCA IgA and IgG titres seemed to correlate well with clinical Crohn ' s disease activity in children . - pubmed
MATERIAL AND METHODS : We carried out univariate and multivariate analyses in an attempt to establish statistically significant preoperative ( age , rectal examination , PSA , biopsy Gleason score , uni / bilateral tumor , affected cylinder percentage ) and postoperative ( pT stage , pN lymph node affectation , Gleason score , positive surgical margins , percentage of tumor affectation , perineural infiltration ) risk factors , as well as their relationship with biochemical recurrence ( PSA & gt;0.2 ng / mL ) . - pubmed
At presentation , patients of the BCSH group showed significantly higher values of serum lactate dehydrogenase and had palpable splenomegaly more frequently . - pubmed
OBJECTIVES : To evaluate the relevance of anti - adalimumab ( anti - ADA ) antibodies ( Abs ) and their relationship with clinical / laboratory features in rheumatoid arthritis ( RA ) , ankylosing spondylitis ( AS ) and psoriatic arthritis ( PsA ) . - pubmed
Placenta growth factor and neuropilin-1 collaborate in promoting melanoma aggressiveness . - pubmed
In melanoma models , PlGF enhances tumour growth and neovessel formation , whereas NRP-1 promotes the metastatic process . - pubmed
In this study we investigated whether PlGF and NRP-1 cooperate in promoting melanoma aggressiveness independently of VEGFR-1 . - pubmed
We also compared the levels of PlGF in the plasma of patients affected by metastatic melanoma with those of healthy donors and evaluated whether PlGF levels could be affected by a bevacizumab - containing chemotherapy regimen . - pubmed
Melanoma patients showed a 20 - fold increase in plasma PlGF and the bevacizumab - containing regimen induced a reduction of VEGF - A and in a further increase of PlGF . - pubmed
In conclusion , our studies suggest that the activation of NRP-1 by PlGF directly contributes to melanoma aggressiveness and represents a potential compensatory pro - angiogenic mechanism that may contribute to the resistance to therapies targeting VEGF - A. - pubmed
In this study , therefore , we investigated whether non - viral anti - thymidylate synthase RNAi embedded liposome ( TS shRNA lipoplex ) would effectively guide the downregulation of TS in human malignant mesothelioma MSTO-211H cells . - pubmed
Expression changes of C - myc , Apaf-1 , caspase-3 , interleukin ( IL )- 6 , and IL-17 during the protection against UC injury through chemical stimulation of the PVN in rats were detected by Western blot . - pubmed
After chemical stimulation of the PVN , SOD activity increased , MDA content decreased , C - myc protein expression significantly increased , caspase-3 and Apaf-1 protein expression significantly decreased , and IL-6 and IL-17 expression decreased in colon tissues in rats with UC . - pubmed
In the vaccination model against caries , LIVE system allowed the heterologous expression of Streptococcus mutans antigen GbpB by L. - pubmed
Nonamplification ERBB2 genomic alterations in 5605 cases of recurrent and metastatic breast cancer : An emerging opportunity for anti - HER2 targeted therapies . - pubmed
The authors queried 5605 advanced / metastatic breast cancers ( mBC ) to uncover the frequency of ERBB2mut genomic alterations . - pubmed
Both primary BC ( 52 cases ; 38 % ) and metastatic site biopsies ( 86 cases ; 62 % ) were found to harbor ERBB2mut , which were distributed across carcinoma not otherwise specified ( NOS ) ( 69 cases ; 50 % ) , invasive ductal carcinoma ( IDC ) ( 40 cases ; 29 % ) , invasive lobular carcinoma ( ILC ) ( 27 cases ; 20 % ) , and mucinous mBC ( 2 cases ; 1 % ) . - pubmed
CDH1 mutations were enriched in ERBB2mut mBC ( P<0.0006 ) and associated with recurrent mBC . - pubmed
Metastatic BC driven by ERBB2mut respond to anti - HER2 targeted therapies , and expanding clinical trials designed to detect ERBB2mut by CGP and optimize targeted treatments are warranted . - pubmed
Momelotinib in myelofibrosis : JAK1 / 2 inhibitor with a role in treating and understanding the anemia . - pubmed
Myelofibrosis ( MF ) is a chronic malignancy of the blood - forming system caused by hyperactivation of JAK2 / STAT signaling pathway . - pubmed
Small - molecule inhibitors of JAK2 can variably ameliorate MF - related symptoms caused by chronic inflammation and hepatosplenomegaly . - pubmed
Anemia is a significant problem and adverse prognostic factor in over a third of MF patients and is often worsened by JAK2 inhibitors . - pubmed
The JAK1 / 2 inhibitor momelotinib unexpectedly resulted in reduction of anemia in MF patients during Phase I / II trials . - pubmed
Our data indicate that activation of the renin - angiotensin system through excessive administration of loop - diuretics is associated with a risk of hypovolemia and thus drug - induced hypotension that deserves special attention when considering converting enzyme inhibitor therapy in congestive heart failure . - pubmed
ERCC1 and ERCC2 as predictive biomarkers to oxaliplatin - based chemotherapy in colorectal cancer patients from Egypt . - pubmed
METHODS : The study included 80 CRC patients who received first line oxaliplatin based chemotherapy The expression levels of ERCC1 and ERCC2 - mRNA and proteins were determined in the primary tumors by quantitative real time reverse transcription polymerase chain reaction(RT - qPCR ) and immunohistochemistry ( IHC ) ; respectively . - pubmed
In multivariate analysis performance status ( PS ) , stage of the disease and ERCC1 - mRNA expression were independent prognostic factors for EFS whereas tumor histology and stage of the disease were independent factors for OS . - pubmed
CONCLUSIONS : ERCC1 expression levels may help in selecting patients who benefit from oxaliplatin chemotherapy in stage III & amp ; IV CRC . - pubmed
Vitamin D across growth hormone ( GH ) disorders : From GH deficiency to GH excess . - pubmed
In addition , data on the impact of GH treatment on vitamin D levels in GHD patients are quite conflicting . - pubmed
Conversely , in active acromegaly , a condition characterized by a chronic GH excess , both increased and decreased vitamin D levels have been highlighted , and the interplay between vitamin D and the GH / IGF - I axis becomes even more complicated when we consider the acromegaly treatment , both medical and surgical . - pubmed
De Novo Disruption of the Proteasome Regulatory Subunit PSMD12 Causes a Syndromic Neurodevelopmental Disorder . - pubmed
Adipose angiotensin II type 1 receptor - associated protein ameliorates metabolic disorders via promoting adipose tissue adipogenesis and browning . - pubmed
Our data revealed that adipose ATRAP plays an important role in preventing metabolic disorders and adiponectin possibly mediates the effects of adipose ATRAP . - pubmed
METHODS : Genetic analyses of patients with FH were conducted for LDL - receptor , PCSK9 , and ApoB100 . - pubmed
A significant inverse correlation was found between LDL - C levels and LS ( P & lt ; .001 , r = .728 ) and CS ( P & lt ; .001 , r = .642 ) for all FH patients . - pubmed
Nanoparticle albumin - bound paclitaxel and gemcitabine ( nab - P / G ) is an evidence - based treatment for patients with APC . - pubmed
ABBREVIATIONS : AbTG : Anti - thyroglobulin antibodies ; AbTPO : Anti - peroxydase antibodies ; AML : Acute myeloid leukemia ; APRIL : A proliferating - inducing ligand ; BAFF : B - cell activating factor ; CAPA : Canadian Arthritis Patient Alliance ; CI : Confidence interval ; CIN : Cervical intraepithelial neoplasia ; CT : Computed tomography ; DLBCL : Diffuse large B cell lymphoma ; dsDNA : Double - stranded DNA ; EBV : Epstein - Barr virus ; EULAR European League Against Rheumatism ; IBD : Inflammatory bowel disease ; HBV : Hepatitis B virus ; HCV : Hepatitis C virus ; HIV : Human immunodeficiency virus ; HR : Hazard ratio ; HSIL : High - grade cervical squamous intraepithelial lesions ; HSV : Herpes simplex virus ; HL : Hodgkin lymphoma ; HPV : Human papillomavirus ; MALT : Mucosa - associated lymphoid tissue ; MDS : Myelodysplastic syndrome ; MESNA : 2 - mercaptoethane sodium sulfonate ; NHL : Non - Hodgkin lymphoma ; OR : Odds ratio ; Pap : Papanicolaou ; RA : Rheumatoid arthritis ; SLE : Systemic Lupus erythematous ; SLICC : Systemic International Collaborating Clinics ; SNPs : Single - nucleotide polymorphisms ; SOGC : Society of Obstetricians and Gynaecologists of Canada . - pubmed
Preoperative Th1 / Th2 and related cytokines : Prediction value in postoperative febrile UTI after ureteroscopy in patients with ureteral calculi . - pubmed
OBJECTIVES : The objective of this study was to investigate the role of preoperative Th1 / Th2 cells and related cytokines in the prediction of postoperative febrile UTI after ureteroscopy in patients with ureteral calculi . - pubmed
RESULTS : Compared with patients in non - UTI group , those in febrile UTI group had significantly increased proportions of Th2 cells , levels of Th2 cytokines ( interleukin ( IL )- 4 , IL-10 and IL-5 ) , and mRNA expression of Th2 - associated transcription factor GATA3 ( all p & lt ; 0.05 ) . - pubmed
Receiver operating characteristic ( ROC ) curve analysis showed that the accuracy rate of Th2 % , Th1 / Th2 ratio , and IL-4 , IL-10 and IL-5 levels for the diagnosis of postoperative febrile UTI in patients with ureteral calculi was 90.63 % , 85.00 % , 72.50 % , 87.50 % , and 91.88 % , respectively , and their combined diagnostic sensitivity was 97.4 % with specificity as high as 100 % . - pubmed
INTRODUCTION : Once - weekly semaglutide is a novel glucagon - like peptide-1 ( GLP-1 ) analogue for the treatment of type 2 diabetes that was associated with greater reductions in glycated hemoglobin ( HbA1c ) and body mass index ( BMI ) versus once - daily GLP-1 analogue liraglutide in a recent network meta - analysis ( NMA ) . - pubmed
Here , immunohistochemistry of CYP11B1 and B2 was used to investigate whether these markers could aid in the diagnostic workup of primary aldosteronism patients . - pubmed
The hyperplasia diagnosis was suggested when there was no dominating nodule but immunoreactivity for CYP11B2 was seen in several nodules , which were also seen on routine sections . - pubmed
To distinguish between adenoma and hyperplasia , a ratio between the largest and second largest CYP11B2 - positive nodules was calculated . - pubmed
CONCLUSION : : Immunohistochemistry detecting CYP11B1 and B2 expression is of great help in establishing a final histopathological diagnosis in patients with primary aldosteronism . - pubmed
In this study , a strategy was proposed to utilize type II collagen ( Col - II ) gels with autologous bone marrow - derived cells ( BMDCs ) embedded to repair full - thickness chondral defects . - pubmed
Midbrain - specific organoids derived from PD patients carrying the LRRK2 - G2019S mutation recapitulate disease - relevant phenotypes . - pubmed
The floor plate marker FOXA2 , required for mDAN generation , increases in PD patient - derived midbrain organoids , suggesting a neurodevelopmental defect in mDANs expressing LRRK2 - G2019S. - pubmed
Expression of PD-1 / PD - L1 in primary breast tumours and metastatic axillary lymph nodes and its correlation with clinicopathological parameters . - pubmed
The aim of this study was to compare the expression of PD-1 / PD - L1 in primary breast tumours to that in metastatic axillary lymph nodes and to determine the correlation between the PD-1 / PD - L1 status and clinicopathologic characteristics . - pubmed
Significant differences in PD - L1 expression were observed between primary breast tumours and paired axillary lymph nodes . - pubmed
Since heterogeneity exists , it is necessary to determine the PD - L1 status in both the primary tumour and metastatic lymph nodes . - pubmed
Farnesoid X receptor ( FXR)-agonists have been approved und used in other liver diseases , such as primary biliary cholangitis ( PBC ) and primary sclerosing cholangitis ( PSC ) , and have shown signs of being able to decrease inflammation and potentially steatosis . - pubmed
The results indicated that PRP could improve wound healing process of deep partial - thickness burns in Bama pigs . - pubmed
We demonstrated that applying PRP had a greater potential for the treatment of deep partial - thickness burns . - pubmed
In this study , we hypothesized that heme oxygenase-1 ( HO-1 ) , an enzyme responsible for degradation of heme to carbon monoxide ( CO ) , bilirubin , and iron is an important regulator of inflammation and epithelial responses in the prostate . - pubmed
coli infection in macrophages and was in part required for IL-1beta expression and prostate cancer cell colony growth in soft agar . - pubmed
In summary , these results suggest that HO-1 / CO might play a distinctive role in modulating prostate inflammation , cell proliferation and IL-1beta induction in part via an ACSL1 - mediated pathway . - pubmed
LncRNA CTBP1 - AS2 sponges miR-216a to upregulate PTEN and suppress endometrial cancer cell invasion and migration . - pubmed
BACKGROUND : Although lncRNA CTBP1 - AS2 has been functionally analyzed only in cardiomyocyte hypertrophy and diabetes , analysis of TCGA dataset revealed its downregulation in endometrial carcinoma ( EC ) , indicating its involvement in EC . - pubmed
RESULTS : In this study we found that CTBP1 - AS2 was downregulated in EC and correlated with poor survival . - pubmed
Transwell assay showed that CTBP1 - AS2 and PTEN overexpression led to decreased cancer cell invasion and migration and reduced enhancing effects of miR-216a on cell invasion and migration . - pubmed
CONCLUSION : Therefore , CTBP1 - AS2 may sponge miR-216a to upregulate PTEN , thereby suppressing endometrial cancer cell invasion and migration . - pubmed
Directly impacting NK cell function , KIR polymorphism associates with infection control and multiple autoimmune and pregnancy syndromes . - pubmed
The KCNJ2 gene mutations induce short QT syndrome ( SQT3 ) by directly increasing the I K1 current . - pubmed
However , the KCNJ2 E299V mutation is distinguished from other representative gene mutations that can induce the short QT syndrome ( SQT3 ) in that it increased I K1 current by impairing the inward rectification of K+ channels . - pubmed
Therefore , we investigated the electrophysiological changes and the concomitant mechanical responses according to the expression levels of the KCNJ2 E299V mutation during sinus rhythm and ventricular fibrillation . - pubmed
We concluded that in both sinus rhythm and fibrillation , the KCNJ2 E299V mutation results in very low contractility regardless of the expression level of mutation and increases the risk of cardiac arrest and cardiac death . - pubmed
DISCOVERY : prevalence of transthyretin ( TTR ) mutations in a US - centric patient population suspected of having cardiac amyloidosis . - pubmed
Methods : DISCOVERY , a multicenter screening study , enrolled patients with clinically suspected cardiac amyloidosis to determine the frequency of transthyretin ( TTR ) mutations and assess disease characteristics . - pubmed
Conclusions : Pathogenic TTR mutations occurred in 8 % of US patients with suspected cardiac amyloidosis . - pubmed
The results revealed that GelMA / HA - DA / GO - betaCD - BNN6 was an ideal antibacterial material that improved collagen deposition and angiogenesis and promoted wound healing in a mouse model of full thickness skin repair , compared with the commercially - available Aquacel Ag dressing . - pubmed
Cutaneous HPV16 and p16 Positive Basaloid Squamous Cell Carcinoma with Brain Metastasis : A Case Report . - pubmed
In contrast , oncogenic human papillomavirus and p16 are screened in head and neck squamous cell carcinoma for prognostication . - pubmed
P16 , a surrogate marker for human papillomavirus infection and specifically HPV16 was identified in the tumor . - pubmed
circRNA RNF111 regulates the growth , migration and invasion of gastric cancer cells by binding to miR-27b-3p . - pubmed
hsa_circ_0001982 [ circRNA ring finger protein 111 ( RNF111 ) ] has been found to promote cancer growth ; however , its role in gastric cancer ( GC ) remains unclear . - pubmed
The present study examined the effects of circR - RNF111 on the growth , migration and invasion of GC cells and aimed to elucidate the underlying molecular mechanisms . - pubmed
The expression levels of circR - RNF111 and miR-27b-3p in GC tissues and GC cell lines were detected by reverse transcription - quantitative PCR ( RT - qPCR ) . - pubmed
The effects of circR - RNF111 and miR-27b-3p on cell growth , apoptosis , migration and invasion were detected by cell counting kit-8 ( CCK-8 ) assay , colony formation assay , flow cytometry , wound - healing assay and Transwell assay , respectively . - pubmed
The results revealed that circR - RNF111 and miR-27b-3p were closely related to the clinicopathological characteristics of GC , and that circR - RNF111 and miR-27b-3p negatively correlated and were abnormally expressed in GC . - pubmed
Furthermore , miR-27b-3p inhibition reversed the regulatory effects of circR - RNF111 silencing on the GC cells . - pubmed
On the whole , the findings of the present study demonstrate that circR - RNF111 is involved in the regulation of growth , migration and invasion of GC cells by binding to miR-27b-3p . - pubmed
Role of Chrysophanol in Epithelial - Mesenchymal Transition in Oral Cancer Cell Lines via a Wnt-3 - Dependent Pathway . - pubmed
Immunoglobulin M for dengue was confirmed and second - degree atrioventricular block Mobitz I with bradycardia ( 40 beats / minute ) was documented throughout the clinical course . - pubmed
CONCLUSIONS : SLC2A3 and MAN2A1 may be important genes for the pathogenesis of CTEPH . - pubmed
BACKGROUND : Transition to dolutegravir - based regimens in resource - limited settings ( RLS ) requires prior understanding of HIV-1 integrase variants and conserved regions . - pubmed
Selected rabbit antisera to cholera toxin antigens and convalescent cholera patient sera were analyzed using the permeability factor neutralization test and two sensitive in vitro serological assays specific for cholera toxin , cholera toxin A subunit , and cholera toxin B subunit . - pubmed
F(ab')2 fragments purified from selected positive and negative MS and control sera gave no staining , though IgG fractions from the same sera prior to pepsin digestion gave positive staining . - pubmed
These results indicate that oligodendrocyte staining is not specific for MS , is not due to specific antibody , and is probably the result of nonspecific binding to Fc receptors . - pubmed
In spite of significantly higher serum insulin levels the t 1/2 Leu in patients with cirrhosis of the liver was significantly prolonged compared with healthy controls after leucine administration as well after leucine and glucose administration . - pubmed
Therefore we conclude , that in patients with cirrhosis of the liver in spite of elevated serum insulin levels leucine as well as glucose are metabolized slower . - pubmed
[ Immunocytes and immunoglobulins of the digestive tract during primary immune deficiencies in adults . - pubmed
The 5 groups were ( a ) healthy non - diabetic subjects not exposed to vibration ( n = 10 , mean age 52.3 yrs ) ( b ) 2 insulin dependent and 8 non - insulin dependent diabetic subjects with a mean of 6 years treatment ( n = 10 , mean age 55.7 yrs ) ( c ) maintenance employees exposed to high frequency pneumatic hand tools ( n = 10 , mean age 52.2 yrs ) ( d ) subjects who were not diabetic or exposed to vibrating tools , but were being treated with the ACE - inhibitor enalapril 20 mg daily for hypertension ( n = 5 , mean age 54 yrs ) ( e ) subjects who had smoked more than 10 cigarettes daily for at least 15 yrs ( n = 10 , mean age 51 yrs ) . - pubmed
Improvements were made in the immunodetection of anti - galactocerebroside ( anti - GalC ) antibody in sera of patients with human African trypanosomiasis by thin - layer chromatography , enzyme - linked immunosorbent assay , and immunoadsorption . - pubmed
Anti - GalC antibodies were found in the sera of 42.8 % of 63 patients with human African trypanosomiasis . - pubmed
Anti - GalC levels were higher in human African trypanosomiasis patients with neurologic disturbances compared with patients without such disturbances . - pubmed
These antibodies were distributed mainly between the IgG and IgM classes , but 28 % of the patients with human African trypanosomiasis had increased IgA levels without anti - GalC antibody activity . - pubmed
Mucin positivity as well as immunoreactivity for epithelial membrane and carcinoembryonic antigens were confined to metastatic adenocarcinoma in this case , whereas Ki-1 and alpha - fetoprotein immunostaining were restricted to the ten control cases of germ cell tumors . - pubmed
Immunologic measurements of the serum concentration of prostate - specific antigen ( PSA ) , an abundant prostatic - secreted serine proteinase , are frequently used to monitor patients with prostate cancer , though it has not been ascertained whether this immunoreactivity represents a PSA zymogen , the active proteinase , or PSA complexed to extracellular proteinase inhibitors . - pubmed
Normovolemic hemodilution under normoxic conditions ( arterial oxygen partial pressure normal ) at rest is limited by the critical arterial oxygen content of about 10 ml / dl corresponding to a hemoglobin concentration of 7.5 g / dl . - pubmed
Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum . - pubmed
To evaluate the potential clinical utility of recombinant human DNase I ( rhDNase ) in the treatment of cystic fibrosis , we have cloned , sequenced , and expressed rhDNase . - pubmed
Catalytic amounts of rhDNase greatly reduce the viscosity of purulent cystic fibrosis sputum , transforming it within minutes from a nonflowing viscous gel to a flowing liquid . - pubmed
Inhalation of a rhDNase aerosol may be a simple direct approach that will help individuals with cystic fibrosis and other patients with pneumonia or bronchitis to clear their airways of purulent secretions . - pubmed
Experimental study of WGA binding on the endothelial cell surface in cerebral ischemia . - pubmed
In the present study , wheat germ agglutinin ( WGA ) was perfused into capillaries in the area postrema of the normal Mongolian gerbil , where the blood brain barrier ( BBB ) is known to lack , and into intracerebral blood vessels , the BBB of which had been destroyed by experimentally induced brain ischemia . - pubmed
The gerbil , in which cerebral ischemia had been induced , also showed partial defect of the reaction with WGA on the luminal side of the endothelial cells . - pubmed
Four subtypes of muscarinic acetylcholine receptor ( mAChR ) were stably expressed in neuroblastoma - glioma hybrid cells ( NG108 - 15 ) . - pubmed
Antibody prevalence increased with age for all three staff groups , as did the number of individuals exhibiting a marker pattern ( HBcAb greater than HBsAb ) suggestive of persisting infection . - pubmed
Steroid receptors and progestinic therapy in ovarian endometrioid carcinoma . - pubmed
Their search for ER and PgR receptors in the tumour tissue showed a particularly high incidence of positive cases ( 81.3 % and 72.1 % respectively ) . - pubmed
Furthermore , the adjuvant , high - dose MAP therapy ( Farlutal ) obtained a high incidence of positive responses with neoplastic regression in 53.5 % of the patients , all of whom were PgR - and/or ER - positive cases . - pubmed
From this standpoint too , the Authors compare ovarian endometrioid carcinoma to endometrial carcinoma and believe that the determination of estrogen and progesterone receptors in the neoplastic tissue can apply to the former too as a cryterion to select patients eligible for progestinic therapy . - pubmed
Among the behavioral variables , HDL change was positively associated with change in alcohol use in both sexes and with change in postmenopausal estrogen use in women and was inversely associated with change in obesity index in men . - pubmed
LDL change correlated positively with change in obesity index in both sexes . - pubmed
Sulfonylureas are the chief therapy for patients with NIDDM ; for a limited time , these agents stimulate increased insulin secretion . - pubmed
With chronic administration , sulfonylureas improve the diabetic patient 's insulin activity by increasing cellular insulin receptors and reducing insulin postreceptor defects . - pubmed
Regulation of proteolytic processing of the amyloid beta - protein precursor of Alzheimer ' s disease in transfected cell lines and in brain slices . - pubmed
beta A4 is the principal component of Alzheimer ' s disease brain amyloid . - pubmed
Influence of lung maturity on bronchoalveolar fibrin deposition and clearance in lung injury syndromes . - pubmed
All the doses of Amitriptyline produced significant hyperglycemia at 4 h , which attained a peak at 24 h with 16 mg / kg dose and appears to be due to blockade of the uptake of monominergic transmitters across the axoplasmic membrane , It ( 16 mg / kg ) also produced glucose intolerance during early hours probably due to interference with gastrin function . - pubmed
The involvement of catecholamines , in hypertension , alcohol and ACE - inhibition . - pubmed
The serotonergic 5 - HT2A receptors are involved in stress - induced anorexia and regulate the hyperphagia induced by neuropeptide Y in the nucleus paraventricularis of the hypothalamus . - pubmed
Synthetic MHC class I peptide prolongs cardiac survival and attenuates transplant arteriosclerosis in the Lewis-->Fischer 344 model of chronic allograft rejection . - pubmed
The addition of HLA - B7.75 - 84 decreased overall cellularity ( P<0.01 ) without affecting the composition of the infiltrate , but completely prevented transplant arteriosclerosis , diminished myocardial injury , and abrogated expression of IL-2R , IL-2 , interferon - gamma , tumor necrosis factor - alpha , and transforming growth factor - beta . - pubmed
CONCLUSIONS : Therapy with synthetic class I major histocompatibility complex peptide ( HLA - B7.75 - 84 ) attenuates key histologic features of graft arteriosclerosis , in association with inhibition of multiple cytokines and growth factors and modulation of host alloantibody responses in vivo , which is of interest since Allotrap is currently undergoing clinical trials . - pubmed
Immunohistochemical evaluation of bcl-2 oncoprotein in oral dysplasia and carcinoma . - pubmed
The proto - oncogene bcl-2 is associated with follicular lymphoma involving translocation t(14;18)(q32;q21 ) and is also overexpressed in various neoplasms . - pubmed
We report deregulation of bcl-2 expression during progression from oral epithelial dysplasia to squamous cell carcinoma . - pubmed
Immunohistochemical analysis with monoclonal antibodies to bcl-2 oncoprotein in formalin - fixed paraffin - embedded tissue sections revealed that severe epithelial dysplasias had a higher percentage of immunoreactivity than did mild and moderate dysplasias and squamous cell carcinomas . - pubmed
Expression of this oncoprotein was directly proportional to the degree of epithelial dysplasia , and nondysplastic basal cells contiguous to neoplastic lesions also expressed bcl-2 . - pubmed
These findings , along with down - regulation of bcl-2 in differentiating carcinomas , suggest a role for this oncoprotein in relatively early stages of oral tumor progression . - pubmed
Osthol and total coumarins of Fructus Cnidii were given to the model of Kidney - Yang Deficiency rats induced by hydrocortison acetate injection , the changes of serum concentration of thyroxine T3 , reverse T3 ( rT3 ) , T4 and thyroid stimulating hormone ( TSH ) were observed . - pubmed
RT - PCR was performed to investigate the carboxyl terminus of the published sequence of hMUC3 from normal colon and small intestine tissues and also from a series of 10 colorectal cancer cell lines . - pubmed
Nine out of 10 colorectal cancer cell lines were found to express MUC3 . - pubmed
METHODS : A total of 11 B - CLL patients were studied with regard to exposure of leukemic lymphocytes with ( n = 8) or without ( n = 3 ) P2z receptors to ATP , benzoylbenzoic - ATP ( BzATP ) , 2 - methylthio - ATP ( 2MeSATP ) , adenosine-5 '-[ gamma - thio ] triphosphate ( ATP - gamma S ) , and other nucleosides for 8 h in vitro . - pubmed
GM - CSF regulates bleomycin - induced pulmonary fibrosis via a prostaglandin - dependent mechanism . - pubmed
To characterize the role of GM - CSF in pulmonary fibrosis , we have studied bleomycin - induced fibrosis in wild - type mice vs mice with a targeted deletion of the GM - CSF gene ( GM - CSF-/- mice ) . - pubmed
Without GM - CSF , pulmonary fibrosis was worse both histologically and quantitatively . - pubmed
We do not have yet sufficient data to conclude whether maximal androgen blockade from the combined use of an LH - RH agonist and an antiandrogen will prolong the survival in patients with metastatic prostate cancer , nor to conclude whether neoadjuvant androgen ablation therapy improves the disease - free survival of patients after radical prostatectomy . - pubmed
Pain associated with injection of botulinum A exotoxin reconstituted using isotonic sodium chloride with and without preservative : a double - blind , randomized controlled trial . - pubmed
Survivin is a member of the inhibitor of apoptosis protein ( IAP ) family that is overexpressed during G(2)/M phase in most cancer cells . - pubmed
IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4 + mucosal T cells in mice . - pubmed
We have previously demonstrated that mucosal CD4(+ ) T cells expressing high levels of IL-7 receptor ( IL-7R(high ) ) are pathogenic cells responsible for chronic colitis . - pubmed
Here we investigate whether IL-7 is directly involved in the expansion of IL-7R(high ) memory CD4(+ ) mucosal T cells and the exacerbation of colitis . - pubmed
We first showed that CD4(+ ) lamina propria lymphocytes ( LPLs ) from wild - type , T cell receptor - alpha - deficient ( TCR - alpha(-/- ) ) , and recombinase - activating gene ( RAG)-2(-/-)-transferred mice with or without colitis showed phenotypes of memory cells , but only CD4(+ ) LPLs from colitic mice showed IL-7R(high ) . - pubmed
Importantly , in vivo administration of IL-7 mice accelerated the expansion of IL-7R(high ) memory CD4(+ ) LPLs and thereby exacerbated chronic colitis in RAG-2 (-/- ) mice transferred with CD4(+ ) LPLs from colitic TCR - alpha (-/- ) mice . - pubmed
Conversely , the administration of anti - IL-7R monoclonal antibody significantly inhibited the development of TCR - alpha(-/- ) colitis with decreased expansion of CD4(+ ) LPLs . - pubmed
Therefore , therapeutic approaches targeting the IL-7R pathway may be feasible in the treatment of human inflammatory bowel disease . - pubmed
Outer membrane protein with a 53 - kDa molecular weight ( Ag53 ) isolated from Porphyromonas gingivalis evokes strong humoral immune responses in many periodontitis patients . - pubmed
To examine the effects of cytokines produced by Ag53 - specific Th cells on the IgG production against Ag53 , we established Ag53 - specific Th - cell lines from patients with early onset periodontitis and from healthy volunteers . - pubmed
Phosphorylation of the 6 - phosphofructo-2 - kinase / fructose 2,6 - bisphosphatase / PFKFB3 family of glycolytic regulators in human cancer . - pubmed
PFKFB3 protein is expressed in high levels in human tumors in situ . - pubmed
EXPERIMENTAL DESIGN : cDNA from several human tumor cell lines and human colon carcinoma were analyzed by reverse transcription - PCR to identify different splicing variants of PFKFB3 . - pubmed
The phosphorylation of PFKFB3 protein in human cancer was determined by immunostaining using an anti - phospho - PFK-2(PFKFB3 ) antibody . - pubmed
Quantitative , real - time PCR analysis confirmed the overexpression of PFKFB3 mRNA in colon carcinoma , with the dominant variant being the PFKFB3 - ACG isoform that contains a phosphorylation site at Ser461 . - pubmed
CONCLUSIONS : These findings support a potential role for the phosphorylation of PFKFB3 protein in the progression of cancer and angiogenesis . - pubmed
Diabetic nephropathy is diagnosed either when persistent increase of urinary albumin excretion rate ( UAER ) above 30 mg/24h in a patient with diabetes was discovered ( early or incipient nephropathy ) or when UAER values are persistently elevated above 300 mg/24h ( overt or clinical nephropathy ) . - pubmed
Microalbuminuria is currently regarded as a marker of generalized endothelial damage , it reflects transvascular albumin leakage , now recognized as an early event in atherogenesis . - pubmed
Recently the association of microalbuminuria with the marker of chronic inflammation ( C - reactive protein ) and with increased production of vascular endothelial growth factor ( VEGE ) was described . - pubmed
Leptin and renal disease . - pubmed
This review elucidates the complex uremic state , the historical discovery of leptin and its physiology , and the potential interactions leptin has on both the progression of kidney disease as well as the morbidity and mortality of end - stage renal disease . - pubmed
CONCLUSION : Persisting duodenal hyperacidity is created by an inherited high PCM and loss of gastrin control . - pubmed
CONCLUSION : The ability of phiC31 integrase to facilitate genomic integration in synovial cells and increase transgene expression in the rabbit synovium suggests that , in combination with more efficient DNA delivery methods , this integrase system could be beneficial for treatment of rheumatoid arthritis and other joint disorders . - pubmed
Maternal serum free beta - hCG levels were lower in pregnancies complicated by pre - eclampsia than in normotensive ones . - pubmed
Multivariable analysis found PAPP - A to be an independent predictor of absolute birth weight , SGA , and LGA . - pubmed
Free beta - hCG was found to be an independent predictor of gestational hypertension and pre - eclampsia . - pubmed
CONCLUSION(S ): Maternal serum PAPP - A levels in the late first trimester of pregnancy are associated with subsequent fetal growth ( including both physiologic variation and abnormal growth ) , and decreased free beta - hCG is more predictive of hypertensive disorders of pregnancy . - pubmed
In the breeds analysed [ Charolais , Czech Spotted ( Czech Simmental ) , Belgian Blue , Limousine , Blonde d'Aquitaine , Aberdeen Angus , and Beef Simmental sires reared in the Czech Republic ] , the recessive allele was not found in the PYGM ( phosphorylase glycogen , muscle ) responsible for the glycogen storage disease type V. - pubmed
In the same panel , the recessive allele in exon 7 , exon 9 and exon 13 of the GAA ( glucosidase alpha , acid ) , causing the glycogen storage disease type II was not found . - pubmed
We determined if exposure to the duodenal helminth Heligmosomoides polygyrus establishes cytokine pathways in the distal intestine that may protect from intestinal inflammation . - pubmed
polygyrus were resistant to trinitrobenzenesulfonic acid ( TNBS)-induced colitis , a Th1 cytokine - dependent inflammation . - pubmed
IL-10 blockade in vivo worsened TNBS colitis in H. - pubmed
Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C. - pubmed
Furthermore , an association study was performed , testing three single nucleotide polymorphisms ( SNPs ) of suppressor of cytokine signalling 3 ( SOCS3 ) in 162 NR and 184 SVR subjects ( SOCS3 -8464 A / C ( rs12952093 ) , -4874 A / G ( rs4969170 ) and 1383 A / G , ( rs4969168 ) ) . - pubmed
Use of aromatase inhibitors rather than tamoxifen for breast cancer will likely lead to more osteoporosis . - pubmed
Aminoglycosides were systemically delivered to two rodent models of retinal degeneration : a transgenic rat model of dominant disease caused by a PTC in rhodopsin ( S334ter ) ; and a mouse model of recessive disease ( rd12 ) caused by a PTC in the retinoid isomerase Rpe65 . - pubmed
Here , we report that H2O2 - induced cellular toxicity acts through Prdx6 hyperoxidation . - pubmed
Expression and function of phospholipase C in breast carcinoma . - pubmed
In liver fibrosis , dendritic cells govern hepatic inflammation in mice via TNF - alpha . - pubmed
Epigenetically regulated clonal heritability of CTA expression profiles in human melanoma . - pubmed
The intratumoral heterogeneity of cancer testis antigens ( CTA ) expression , which is driven by promoter methylation status , may hamper the effectiveness of CTA - directed vaccination of melanoma patients . - pubmed
Most inhaled food allergy is IgE mediated , and skin prick tests or specific IgE tests are useful tools to support the diagnosis , but objective evidence of asthma by monitoring of peak expiratory flows at and off work or specific inhalation challenges offers a better diagnostic value . - pubmed
These data suggest that AP - aldolase is stabilized by binding to the native structure , and they provide a foundation for developing stabilizing compounds for potential therapeutics for HFI . - pubmed
Human ZNF312b oncogene is regulated by Sp1 binding to its promoter region through DNA demethylation and histone acetylation in gastric cancer . - pubmed
In a previous study , human ZNF312b was identified as a cell proliferation - associated oncogene via the K - ras / extracellular signal - regulated kinase cascade in gastric cancer . - pubmed
Here , we show that DNA methylation and histone acetylation of the ZNF312b promoter function as a switch for ZNF312b transcriptional activation in gastric cancer . - pubmed
The transcription level of ZNF312b was increased by treatment with a demethylating agent , 5 - aza-2 '- deoxycytidine and the histone deacetylase inhibitor sodium butyrate , in several human cancer cell lines including gastric cancer . - pubmed
Consistent with these results , epigenetic analysis , such as pyrosequencing , bisulfate sequencing and methyl - specific polymerase chain reaction ( MSP ) , showed that the expression level of ZNF312b is highly dependent on the degree of DNA methylation in gastric cancer cell lines . - pubmed
Moreover , a knockdown of Sp1 resulted in a decrease in ERK - mediated proliferation via downregulation of the ZNF312b gene in gastric cancer cells . - pubmed
Taken together , these results suggest that the aberrant expression of ZNF312b promotes gastric tumorigenesis through epigenetic modification of its promoter region and provides a molecular mechanism for ZNF312b expression to contribute to the progression of gastric cancer . - pubmed
B - type natriuretic peptide levels predict extent and severity of coronary disease in non - ST elevation coronary syndromes and normal left ventricular systolic function . - pubmed
BACKGROUND : B - type natriuretic peptide ( BNP ) has been used recently as a biological marker in patients with coronary artery disease ( CAD ) with ST - elevation , as well as without ST - elevation . - pubmed
BNP is able to predict systolic dysfunction , adding new prognostic information to existing traditional markers . - pubmed
However is not known if there is a relation between the quantity of BNP levels and the severity of coronary artery disease . - pubmed
METHODS : This study compared B - type natriuretic peptide ( BNP ) levels in patients with stable angina ( SA ) and acute coronary syndromes ( ACS ) without ST - elevation in relation to angiographic lesions using TIMI and Gensini Scores . - pubmed
RESULTS : BNP values were progressively increased in relation to the severity of diagnosis : SA ( 52.6 + -49.4 pg / mL ) UA ( 243.3 + -212 pg / mL ) NSTE - ACS ( 421.7 + -334 pg / mL ) ( p<0.0001 and p<0.007 respectively ) . - pubmed
The analysis of BNP levels in relation to the number of involved vessels demonstrated significantly increased levels in patients with multivessel disease compared to patients with 1 or 2 vessel disease ( 1 - 86.2 + -46.3 pg / mL ; 2 - 127 + -297 pg / mL ; 3 - 295 + -318 pg / mL ; 4 - 297 + -347 pg / mL p<0.001 and p<0.003 ) . - pubmed
Evaluation of BNP using Gensini Score showed a strong relation between BNP and coronary disease extension ( r=0.38 p<0.0001).This trend was maintained in all CAD groups ( SA = r 0.54 ; UA r=0.36 NSTE - ACS r=0.28 ) . - pubmed
CONCLUSIONS : Circulating BNP levels appear elevated in ACS with diffuse coronary involvement , even in the absence of systolic dysfunction . - pubmed
BNP is also associated with multi - vessel disease and the extension of coronary disease . - pubmed
Labeled cardiac stem cells were identified in the infarct zone and infarct marginal zone and expressed Connexin-43 , von Willebrand factor , alpha - smooth muscle actin , and alpha - sarcomeric actin . - pubmed
Recently , evidence has also emerged that renin - angiotensin system ( RAS ) inhibitors may electively prevent or delay progression of retinopathy , possibly because of specific protective effect against the structural and functional retinal changes sustained by local RAS activation . - pubmed
Thus , metabolic and blood pressure control by RAS inhibition is to prevent or limit the onset of retinopathy and its progression towards visual - threatening stages . - pubmed
Topic treatment with anti - vascular endothelial growth factor ( VEGF ) agents is emerging as a treatment option for retinopathy in advanced stages to limit the need for laser photocoagulation . - pubmed
Blocking of selectins is therefore considered a promising therapeutic approach to treat acute and chronic inflammatory diseases which are caused by excessive extravasation of leukocytes . - pubmed
Moreover , significant correlation was found between multiple viral infection ( JCV , and/or SV40 , and/or MMTV - like in the same tumor ) and " triple negative " phenotype ( P = 0.001 ) and also with p53 accumulation ( P = 0.028 ) . - pubmed
Glomerular expression of hydrogen peroxide - inducible clone-5 in human and rat progressive mesangial proliferative glomerulonephritis . - pubmed
BACKGROUND / AIMS : Hydrogen peroxide - inducible clone-5 ( Hic-5 ) is a transforming growth factor - beta ( 1 ) ( TGF - beta ( 1 ))- and hydrogen peroxide ( H ( 2 ) O ( 2 ))- inducible focal adhesion protein that may be necessary for maintaining the myofibroblastic phenotype in pathological scar formation . - pubmed
To investigate the involvement of Hic-5 in the pathogenesis of glomerulonephritis ( GN ) , we examined the glomerular expression of Hic-5 in human and rat GN as well as the regulation of Hic-5 by TGF - beta ( 1 ) in vitro . - pubmed
Hic-5 expression was significantly correlated not only with the levels of alpha - smooth muscle actin ( alpha - SMA ) and TGF - beta ( 1 ) , the accumulation of extracellular matrix , and the number of glomerular cells , but also with the urinary protein level in patients with GN . - pubmed
Glomerular Hic-5 expression increased in parallel with alpha - SMA expression in a rat model of mesangial proliferative GN . - pubmed
CONCLUSION : Our findings suggest that Hic-5 is involved in changes in the MC phenotype to produce abnormal extracellular matrix remodeling in GN . - pubmed
Many members of the NOD - like receptor ( NLR ) family play important roles in pathogen recognition and inflammation . - pubmed
The HAP - induced DNA damage and cytotoxicity observed in ITPA knockdown cells are rescued by an overexpression of the yeast ITPase encoded by the HAM1 gene . - pubmed
T - cell receptor signaling and the pathogenesis of autoimmune arthritis : insights from mouse and man . - pubmed
In this review we consider recent evidence that has provided insight into how altered TCR signaling thresholds could contribute to human autoimmune arthritis , including rheumatoid arthritis ( RA ) , and the spondyloarthropathies ( SpA ) . - pubmed
From genetic association studies to the biology of interleukin-28B in hepatitis C virus infection and beyond . - pubmed
In this study , we used quantitative real - time PCR and a luciferase reporter assay to determine whether PPV infection induces type I interferon ( IFN - alpha and IFN - beta ) and whether PPV infection blocks dsRNA - induced IFN - beta promoter activation in cell cultures . - pubmed
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia . - pubmed
Recently , somatic mutations in the signal transducer and activator of transcription 3 ( STAT3 ) gene were discovered in 28 % to 40 % of LGL leukemia patients . - pubmed
By exome and transcriptome sequencing of 2 STAT3 mutation - negative LGL leukemia patients , we identified a recurrent , somatic missense mutation ( Y665F ) in the Src - like homology 2 domain of the STAT5b gene . - pubmed
Targeted amplicon sequencing of 211 LGL leukemia patients revealed 2 additional patients with STAT5b mutations ( N642H ) , resulting in a total frequency of 2 % ( 4 of 211 ) of STAT5b mutations across all patients . - pubmed
This is the first time somatic STAT5 mutations are discovered in human cancer and further emphasizes the role of STAT family genes in the pathogenesis of LGL leukemia . - pubmed
Mutations in several genes have been implicated as playing a pathogenic role in the corneal endothelial dystrophies : VSX1 mutations in PPCD1 ; COL8A2 mutations in PPCD2 and FECD ; ZEB1 mutations in PPCD3 and FECD ; and SLC4A11 mutations in CHED2 and FECD . - pubmed
However , linkage , association and familial segregation analyses support a role of only one gene in each corneal endothelial dystrophy : ZEB1 in PPCD3 , SLC4A11 in CHED2 and COL8A2 in FECD ( early onset ) . - pubmed
The classical drug targets for the treatment of schizophrenia are dopamine D2 receptors . - pubmed
Proteinuria and VEGF - targeted therapies : : an underestimated toxicity ? - pubmed
Oncologists and nephrologists usually manage proteinuria related to anti - vascular endothelial growth factor ( anti - VEGF ) treatment only when it is in the nephrotic range or associated with renal insufficiency . - pubmed
We found that proteinuria induced by anti - VEGF therapy , even if weak and without associated renal insufficiency , may reflect a serious histological renal disease . - pubmed
The predisposing role to human obesity of the MC3R gene polymorphism is controversial . - pubmed
Furthermore , the compounds did not show any signs of cardiotoxicity in zebrafish ether - a - go - go - related gene ( zERG ) , and hence constitute a major breakthrough among the otherwise cardiotoxic N - linked aminopiperidine analogues . - pubmed
Seahorse - derived peptide suppresses invasive migration of HT1080 fibrosarcoma cells by competing with intracellular alpha - enolase for plasminogen binding and inhibiting uPA - mediated activation of plasminogen . - pubmed
alpha - Enolase - bound plasminogen promotes tumor cell invasion and cancer metastasis by activating plasmin and consequently degrading the extracellular matrix degradation . - pubmed
Therefore , alpha - enolase and plasminogen are novel targets for cancer therapy . - pubmed
In this study , we report that this peptide competes with cellular alpha - enolase for plasminogen binding and suppresses urokinase plasminogen activator ( uPA)-mediated activation of plasminogen , which results in decreased invasive migration of HT1080 fibrosarcoma cells . - pubmed
Ryk is essential for Wnt-5a - dependent invasiveness in human glioma . - pubmed
Recently , we reported that Wnt-5a was overexpressed and correlated with cell motility and infiltrative activity through the regulation of matrix metalloproteinase ( MMP )- 2 in glioma - derived cells . - pubmed
Although several receptors for Wnt-5a were identified , the receptors of Wnt-5a that mediate cellular responses of glioma were not clearly identified . - pubmed
Knockdown of receptor - like tyrosine kinase ( Ryk ) but not that of Ror2 suppressed the activity of MMP-2 and Wnt-5a - dependent invasive activity in glioma cells . - pubmed
These results suggest that Ryk is important for the Wnt-5a - dependent induction of MMP-2 and invasive activity in glioma - derived cells and that Ryk might have a novel patho - physiological function in adult cancer invasion . - pubmed
Furthermore , not only the expression of Wnt-5a but also that of Frizzled ( Fz)-2 and Ryk was correlated with the WHO histological grade in 38 human glioma tissues . - pubmed
Taking these findings together , Fz-2 and Ryk could be therapeutic or pharmacological target molecules for the control of Wnt-5a - dependent invasion of human glioma in the near future . - pubmed
Omarigliptin ( MK-3102 ): a novel long - acting DPP-4 inhibitor for once - weekly treatment of type 2 diabetes . - pubmed
Immunohistochemically , the tumours were positive for pancytokeratin but negative for synaptophysin and chromogranin A. - pubmed
Previous SS studies have demonstrated an increase in VEGF - A / VEGFR-2 system expression in minor salivary gland ( MSG ) biopsies from patients with SS , but differences in the new blood vessel formation between the different grades of disease severity have not been reported . - pubmed
Actin dynamics are critical for muscle development and function , and mutations leading to deregulation of actin dynamics cause various forms of heritable muscle diseases . - pubmed
In adult mice , Wdr1 deletion resulted in similar but much milder phenotypes of heart hypertrophy , F - actin accumulations within myofibrils , and lethality . - pubmed
Thymidine kinase 1 is a better prognostic marker than Ki-67 for pT1 adenocarcinoma of the lung . - pubmed
OBJECTIVES : The sensitivity and reliability of the biomarkers thymidine kinase 1 ( TK1 ) and Ki-67 were studied in relation to clinical features and prognosis of survival for pathological - T1 ( pT1 ) lung adenocarcinoma patients . - pubmed
METHODS : TK1 and Ki-67 expression was determined in 80 patients with pT1 adenocarcinoma of the lung and in 20 specimens from normal lung tissues , using immunohistochemistry . - pubmed
RESULTS : TK1 was found in most lung tumor cells both in the cytoplasm and the nuclei . - pubmed
There was a significant correlation between the LI of total TK1 and lymph node metastasis , degree of tumor invasion and pathologic stages , which was not found for Ki-67 . - pubmed
In addition , the overall 5 - year survival of patients was statistically significant different between low and high levels of TK1 expression , but not in cases of Ki-67 . - pubmed
A multivariate analysis revealed that expression of TK1 , lymph node involvement and TNM pathology staging could serve as independent prognostic factors for the disease progression of pT1 lung adenocarcinoma patients . - pubmed
CONCLUSIONS : Compared with Ki-67 , TK1 is a more reliable proliferation index in pT1 adenocarcinoma of lung , which can evaluate the invasion and the prognosis of tumor . - pubmed
Bothropoidin induced haemorrhage [ minimum haemorrhagic dose ( MHD ) = 0.75 microg ] , inhibited platelet aggregation induced by collagen and ADP , and interfered with viability and cell adhesion when incubated with endothelial cells in a dose and time - dependent manner . - pubmed
pauloensis envenomation and might be used as a tool for studying the effects of SVMPs on haemostatic disorders and tumour metastasis . - pubmed
GWAS confirm the importance of the alcohol dehydrogenase gene cluster on chromosome 4 in the genetic risk for alcohol dependence with multiple variants that exert a small , but cumulative influence . - pubmed
Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients . - pubmed
To address the relationship between altered expression of DSB repair of proteins Ku70 and ataxia - telangiectasia mutated ( ATM ) in colorectal cancer ( CRC ) , we examined the expression levels and patterns of Ku70 and ATM in CRC samples . - pubmed
METHODS : Expression and coexpression of Ku70 and ATM were investigated by using real - time quantitative polymerase chain reaction assays and confirmed further with fluorescent immunohistochemistry in CRC and pericancerous samples from 112 Chinese patients . - pubmed
RESULTS : Downexpression patterns for both Ku70 and ATM were found in the CRC samples and were significantly associated with advanced tumor node metastasis stage and decreased 5 - year overall survival rate . - pubmed
CONCLUSION : Downregulated Ku70 and ATM were associated with poor disease - free survival . - pubmed
Loss of Ku70 and ATM expression might act as a biomarker to predict poor prognosis in patients with CRC . - pubmed
Expression of high level methicillin resistance in a laboratory MSSA strain resulted in ( i ) repression of PIA - mediated biofilm production , ( ii ) down - regulation of the accessory gene regulator ( Agr ) system , and ( iii ) attenuation of virulence in murine sepsis and device infection models . - pubmed
Molecular characterization and hypoxia - induced upregulation of neuronal nitric oxide synthase in Atlantic croaker : Reversal by antioxidant and estrogen treatments . - pubmed
However , the influence of antioxidants and steroids on nNOS upregulation by hypoxia is largely unknown . - pubmed
In this study , we characterized nNOS cDNA and examined the effects of hypoxia and antioxidant and steroid treatments on nNOS expression in Atlantic croaker hypothalamus . - pubmed
In contrast , treatments with Nomega - nitro - L - arginine methyl ester , a competitive NOS - inhibitor , or vitamin E , an antioxidant , prevented the upregulation of O2 ( - ) production and nNOS expression in hypoxia - exposed ( DO : 1.7 mg / L for 4 weeks ) fish . - pubmed
Moreover , treatment with 1,4,6 - androstatrien-3,17 - dione , an aromatase inhibitor , increased hypothalamic O2 ( - ) production and nNOS expression in normoxic control fish ; whereas estradiol-17beta treatment significantly reduced O2 ( - ) production and nNOS expression in hypoxia - exposed fish . - pubmed
Taken together , the results suggest that upregulation of nNOS and ROS in the croaker hypothalamus in response to hypoxia is influenced by antioxidant and overall estrogen status . - pubmed
Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C - Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors . - pubmed
We assessed the functional activity of CAIX in two colorectal tumor models , expressing different levels of the enzyme , by measuring the rate of exchange of hyperpolarized ( 13 ) C label between bicarbonate ( H ( 13 ) CO3 (- ) ) and carbon dioxide ( ( 13 ) CO2 ) , following injection of hyperpolarized H ( 13 ) CO3 (- ) , using ( 13 ) C - magnetic resonance spectroscopy ( ( 13 ) C - MRS ) magnetization transfer measurements . - pubmed
( 31 ) P - MRS measurements of the chemical shift of the pH probe , 3 - aminopropylphosphonate , and ( 13 ) C - MRS measurements of the H ( 13 ) CO3 (-)/( 13 ) CO2 peak intensity ratio showed that CAIX overexpression lowered extracellular pH in these tumors . - pubmed
Paradoxically , tumors overexpressing CAIX showed lower enzyme activity using magnetization transfer measurements , which can be explained by the more acidic extracellular pH in these tumors and the decreased activity of the enzyme at low pH. - pubmed
These results suggest that CAIX expression is increased in hypoxia to compensate for the decrease in its activity produced by a low extracellular pH and supports the hypothesis that a major function of CAIX is to lower the extracellular pH. - pubmed
Immortalized human esophageal myofibroblasts also express the putative acid receptor TRPV1 and TLR4 and retain the functional capacity to respond to stimuli encountered in GERD with secretion of IL-6 . - pubmed
Therefore , we examined the impact of deletion of the alpha11 integrin in wild - type mice and in mice treated with streptozotocin ( STZ ) to elucidate the role of the alpha11 integrin in normal cardiac homeostasis and in the pathogenesis of diabetes - related fibrosis . - pubmed
As anticipated , cardiac fibrosis was reduced in alpha11 integrin knockout mice ( alpha11(-/- ) ; C57BL/6 background ) treated with STZ compared with STZ - treated wild - type mice ( P & lt ; 0.05 ) . - pubmed
Overall , deletion of the alpha11 integrin attenuates cardiac fibrosis in the mammalian mouse heart and reduces ECM formation as a result of diabetes . - pubmed
In addition , PM2.5 increased the production of granulocyte - macrophage colony - stimulating factor , tumor necrosis factor - alpha , interleukin-13 and eotaxin ( C - C motif chemokine ligand 11 ) , each of which initiates and/or augments local inflammation . - pubmed
In recent research , it has been shown that there have been variants of rs12026 within the paraoxonase 2 ( PON2 ) gene , which have been associated with cardiovascular disease , cerebrovascular disease , diabetes and other diseases . - pubmed
Erratum to : High Jagged1 expression is associated with poor outcome in primary glioblastoma . - pubmed
Detection of Chlamydia was associated with expression of cyclooxygenase-2 and interleukin-8 by superficial epithelial cells . - pubmed
CONCLUSION : Neutrophils , plasma cells and IL-8 have been linked with Chlamydia genital infection of unknown duration in human patients . - pubmed
Hyaluronate synthase-2 overexpression alters estrogen dependence and induces histone deacetylase inhibitor - like effects on ER - driven genes in MCF7 breast tumor cells . - pubmed
In breast carcinoma cells , high levels of hyaluronan ( HA ) and its CD44 receptor are frequently associated with alteration in estrogen signaling . - pubmed
In conclusion , increase in HA / CD44 interactions may contribute , through an HDAC inhibitor - like and ER - independent mechanism , to the silencing of estrogen - driven genes in breast carcinoma . - pubmed
Polymeric immunoglobulin receptors(pIgR ) are key participants in the formation and secretion of secretory IgA(S - IgA ) , which is critical for the prevention of microbial infection and colonization in the respiratory system . - pubmed
Although increased respiratory colonization and infections are common in HIV / AIDS , little is known about the expression of pIgR in the airway mucosa of these patients . - pubmed
These results indicated abnormal pIgR expression in SHIV / SIV , and by extension HIV infections , which might partially result from IL-17A alterations and might contribute to the increased microbial colonization and infection related to pulmonary complications in HIV / AIDS . - pubmed
Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1 - associated myelopathy / tropical spastic paraparesis ( HAM / TSP ) . - pubmed
Interleukin-21 ( IL-21 ) enhances the survival and cytotoxic properties of cytotoxic T cells ( CTLs ) and exhibits essential roles in controlling chronic viral infections . - pubmed
In this study , the expression of host IL-21 and HTLV - I Tax and proviral load ( PVL ) was evaluated to understand the role and mechanism of IL-21 in HTLV-1 infections and the subsequent development of HAM / TSP . - pubmed
A cross - sectional study was carried out on 20 HAM / TSP patients , 20 asymptomatic HTLV-1 carriers ( ACs ) and 20 healthy controls ( HCs ) to evaluate the expression of IL-21 and Tax and PVL in non - activated and phorbol myristate acetate ( PMA)-ionomycin - activated peripheral blood mononuclear cells ( PBMCs ) . - pubmed
The mean mRNA expression of IL-21 in the non - activated and activated PBMCs was higher ( by 5 - 13 times ) in the HAM / TSP patients than in ACs and HCs ( p & lt ; 0.05 ) ; however , there was no significant difference between ACs and HCs . - pubmed
In contrast to the IL-21 mRNA expression , the serum level of the IL-21 protein was significantly lower in the HAM / TSP patients than in ACs and HCs ( p & lt ; 0.05 ) . - pubmed
Furthermore , higher expression of Tax and PVL was observed in the HAM / TSP subjects than ACs ( p & lt ; 0.05 ) . - pubmed
In a post - germinal center B - cell in vitro model , permanent latent membrane protein 1 ( LMP1 ) expression , as observed in Epstein - Barr virus ( EBV )- associated cHL , results in multinuclearity and complex chromosomal aberrations through downregulation of key element of the shelterin complex , the telomere repeat binding factor 2 ( TRF2 ) . - pubmed
Thus , we hypothesized that the three - dimensional ( 3D ) telomere - TRF2 interaction was progressively disturbed during transition from H to RS cells . - pubmed
To this end , we developed and applied for the first time a combined quantitative 3D TRF2 - telomere immune fluorescent in situ hybridization ( 3D TRF2 / Telo - Q - FISH ) technique to monolayers of primary H and RS cells , and adjacent benign internal control lymphocytes of lymph node biopsy suspensions from diagnostic lymph node biopsies of 14 patients with cHL . - pubmed
This pattern is typical of , but is not restricted to , LMP1+EBV - associated cHL . - pubmed
In the disruption pattern B group , so - called ' ghost ' end - stage RS cells , void of both TRF2 and telomere signals , were identified , whether or not associated with EBV . - pubmed
Cytokine expression levels in ALS : A potential link between inflammation and BMAA - triggered protein misfolding . - pubmed
Recently , it has been shown that proinflammatory cytokines play a complex and important role in the pathogenesis of many neurological disorders , including amyotrophic lateral sclerosis ( ALS ) . - pubmed
To help facilitate future discoveries and more effective treatment strategies , we highlight the role that both innate and adaptive immune systems play in ALS and summarize the main observations that relate to cytokine expression levels in this disease . - pubmed
Inhibition of STAT3 signaling pathway by ursolic acid suppresses growth of hepatocellular carcinoma . - pubmed
The signal transducer and activator of transcription 3 ( STAT3 ) has been found to be constitutively active in liver cancer . - pubmed
There is no STAT3 inhibitors approved to be used clinically for the treatment or prevention of liver cancer . - pubmed
However , whether UA could inhibit STAT3 phosphorylation in hepatocellular carcinoma has not been reported . - pubmed
The inhibitory effects of UA on STAT3 phosphorylation , along with cell viability , migration , colony formation in vitro , as well as tumor growth in vivo were examined in human liver cancer cell lines . - pubmed
Our data showed that UA inhibited the P - STAT3 induced by interleukin-6 ( IL-6 ) in Hep3B liver cancer cells which express very low basal level of P - STAT3 . - pubmed
The constitutive STAT3 phosphorylation was also inhibited by UA in HEPG2 , 7721 and Huh7 human liver cancer cell lines . - pubmed
Furthermore , UA suppressed STAT3 phosphorylation and HEPG2 tumor growth by oral daily treatment in vivo . - pubmed
UA , which exists widely in fruits and herbs , could inhibit STAT3 activation and the growth of human liver cancer cells in vitro and in vivo . - pubmed
A polymorphism in ABCC4 is related to efficacy of 5 - FU / capecitabine - based chemotherapy in colorectal cancer patients . - pubmed
Statistical analysis showed that a polymorphism rs3742106 in the 3'-UTR of ATP - binding cassette subfamily C member 4 ( ABCC4 ) gene was significantly associated with the efficacy of 5 - FU / capecitabine - based chemotherapy in CRC . - pubmed
Methods : Adult chemotherapy - naive patients with confirmed prostate adenocarcinoma , Eastern Cooperative Oncology Group ( ECOG ) performance status ( PS ) grade 0 - 1 , ongoing androgen deprivation ( serum testosterone & lt;50 ng / dL ) with prostate specific antigen ( PSA ) or radiographic progression were randomized to receive abiraterone acetate ( 1000 mg , QD ) + prednisone ( 5 mg , BID ) or placebo + prednisone ( 5 mg , BID ) , until disease progression , unacceptable toxicity or consent withdrawal . - pubmed
ST2 blockade during skin sensitization inhibited the development of anaphylaxis , antigen - specific IgE , and inflammatory mediators . - pubmed
BACKGROUND : Imatinib is tyrosine kinase inhibitor ( TKI ) and as a targeted anti - cancer agent has significantly changed chronic myeloid leukemia ( CML ) prognosis and patient survival . - pubmed
RESULTS : Our study proved that CML patients , who had achieved MMR by original imatinib therapy , retained MMR during 24 months of generic imatinib therapy . - pubmed
CONCLUSION : Our study proved that CML patients , who had achieved MMR by original imatinib therapy , retained MMR during 24 months of generic imatinib therapy . - pubmed
Baseline DNAmeth did not differ between GR and WR for any tested genes , even when the analysis was restricted to subjects with no diabetes . - pubmed
The clinical relevance of serum vascular endothelial growth factor ( VEGF ) in correlation to circulating tumor cells and other serum biomarkers in patients with metastatic breast cancer . - pubmed
PURPOSE : VEGF is one of the most important angiogenesis - stimulating cytokines and has been previously shown to be overexpressed in several solid cancers . - pubmed
The aim of the present study was to assess the clinical relevance of serum VEGF ( sVEGF ) in a large cohort of metastatic breast cancer patients and to explore the relationship between sVEGF and other blood - based biomarkers . - pubmed
Circulating tumor cells ( CTCs ) were detected using CellSearch and other biomarkers ( EGFR , HER2 , RAS p21 , TIMP1 , CAIX ) by ELISA . - pubmed
Patients with sVEGF levels & gt;= 367 pg / ml and & gt;= 5 CTCs had the shortest OS , while those with sVEGF & lt ; 367 pg / ml and non - elevated CTCs had the longest OS . - pubmed
CTCs , grading , line of therapy and RAS p21 were independent predictors of OS . - pubmed
CONCLUSIONS : Metastatic breast cancer patients with elevated levels of sVEGF have significantly worse clinical outcome . - pubmed
This finding supports the biological role of VEGF in breast cancer . - pubmed
Joint associations of serum uric acid and ALT with NAFLD in elderly men and women : a Chinese cross - sectional study . - pubmed
BACKGROUND : Epidemiological evidence suggests sex difference in serum uric acid ( SUA ) and alanine aminotransferase ( ALT ) might be a potential explanation for the gender difference in prevalence of non - alcoholic fatty liver disease ( NAFLD ) . - pubmed
METHODS : We conducted a cross - sectional study to assess the joint associations between SUA and serum ALT with NAFLD among elderly Chinese men and women . - pubmed
In addition , the ORs of NAFLD among participants with high SUA levels and high serum ALT was 10.75 ( 95 % CI 3.56 - 32.46 ) for men and 7.96 ( 95 % CI 2.83 - 22.39 ) for women , compared with those with low SUA levels and low serum ALT . - pubmed
A significant joint association of SUA and serum ALT with NAFLD prevalence was observed in all participants , which was slightly stronger in men than in women . - pubmed
Immunoexpression of Transforming Growth Factor Beta 3 ( TGFbeta3 ) and Its Receptor Type III ( TGFbetaRIII ) in Basal Cell Carcinomas . - pubmed
In this study we analyzed the immunoexpression of transforming growth factor beta 3 ( TGFbeta3 ) and its receptor type III ( TGFbetaRIII ) for 53 cases of BCC in relation to the main histopathological prognostic parameters . - pubmed
The results indicated statistically significant differences of TGFbeta3 and TGFbetaRIII expression related to histological type and lesion stage , the both proteins being higher expressed in adenoid and morpheaform advanced stage tumors . - pubmed
In this study , TGFbeta3 and TGFbetaRIII immunoexpression analysis indicated their utility for identifying aggressive BCCs with potential for tumor progression . - pubmed
Based on the initial analysis of kidney renal clear cell carcinoma dataset from The Cancer Genome Atlas , genes MT1E , MT1F , MT1 G and MT1 M were selected for qualitative methylation analysis in 30 tumors ( including 10 multifocal cases ) , 10 pericancerous , and 30 non - cancerous renal tissues ( NRT ) . - pubmed
Methylation of MT1E and MT1 M was tumor - specific ( P=0.0056 and P=0.0486 , respectively ) and showed moderate interfocal variation in paired tumor foci . - pubmed
Furthermore , aberrant MT1E methylation was more frequent in tumors having necrotic zones ( P=0.0449 ) or characterized with higher differentiation grade ( P=0.0144 ) , while MT1 M was more commonly methylated in tumors with higher Fuhrman grade ( P=0.0272 ) . - pubmed
Gene expression analysis ( 51 RCC and 9 NRT ) revealed MT1 G downregulation in tumors ( P<0.0001 ) , while lower MT1E expression levels were associated with the promoter methylation ( P=0.0077 ) . - pubmed
In clear cell RCC , MT1E , MT1 G and MT1 M expression was higher than that noted in other histological tumor subtypes ( all P<0.0500 ) . - pubmed
In conclusion , the present study revealed the potential role of MT1E and MT1 M promoter methylation in RCC development . - pubmed
Genetic variants of calcium sensing receptor gene and risk of colorectal cancer : A case - control study . - pubmed
Objectives : To determine the role of two genetic variants , ( rs3804594 ) and ( rs1801725 ) , in calcium sensing receptor ( CASR ) gene with colorectal cancer ( CRC ) risk in patients visited King Abdulaziz University hospital ( KAUH ) in Jeddah , Saudi Arabia . - pubmed
Results : Data obtained from chi2 test showed that intron 4 variant in CASR gene was distributed 100 % normally in the 224 participants , however , exon 7 variant showed 100 % homozygous distribution in the controls ; whereas , in CRC patients it was distributed equally into 50 % heterozygous and 50 % homozygous with no detection for wild type . - pubmed
Conclusion : Intron 4 variant ( rs3804594 ) in CASR gene is not correlated to CRC risk . - pubmed
However , more investigations are needed to elucidate the role of CASR gene exon 7 ( rs1801725 ) variant in CRC development as the current results are not definitive . - pubmed
The correlation between low - methylation subgroup and IPF was further validated by quantitative methylation analysis of marker genes commonly hypermethylated in SCC ( HOXA2 , HOXA9 and PCDHGB6 ) , and markers specifically hypermethylated in high - methylation subgroup ( DLEC1 , CFTR , MT1 M , CRIP3 and ALDH7A1 ) in 77 SCC cases using pyrosequencing ( p = 0.003 ) . - pubmed
Immunocheckpoint inhibitors including anti - PD-1 antibody have shown certain therapeutic effects on various cancer types . - pubmed
An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma . - pubmed
Glycolytic enzyme phosphoglycerate mutase 1 ( PGAM1 ) plays a critical role in cancer metabolism by coordinating glycolysis and biosynthesis . - pubmed
A well - validated PGAM1 inhibitor , however , has not been reported for treating pancreatic ductal adenocarcinoma ( PDAC ) , which is one of the deadliest malignancies worldwide . - pubmed
By uncovering the elevated PGAM1 expressions were statistically related to worse prognosis of PDAC in a cohort of 50 patients , we developed a series of allosteric PGAM1 inhibitors by structure - guided optimization . - pubmed
The compound KH3 significantly suppressed proliferation of various PDAC cells by down - regulating the levels of glycolysis and mitochondrial respiration in correlation with PGAM1 expression . - pubmed
Similar to PGAM1 depletion , KH3 dramatically hampered the canonic pathways highly involved in cancer metabolism and development . - pubmed
The better responses to KH3 in PDXs were associated with higher expression of PGAM1 and longer / stronger suppressions of cancer metabolic pathways . - pubmed
Taken together , our findings demonstrate a strategy of targeting cancer metabolism by PGAM1 inhibition in PDAC . - pubmed
METHODS AND RESULTS : BALB / C mice with TNBS - induced colitis , when treated with resveratrol , showed improved clinical outcomes and reduced induction of inflammatory T cells ( Th17 and Th1 ) while increasing CD4+Foxp3 + regulatory T cells ( Tregs ) and IL-10 - producing CD4 + T cells . - pubmed
OBJECTIVE : We aimed to investigate whether GRP - GRPR signaling is altered in SDH neurons in a mouse model of chronic itch and to determine the potential mechanisms underlying these alterations . - pubmed
RESULTS : We observed potentiation of GRP - evoked excitation in the GRPR+ SDH neurons of mice with contact dermatitis , without concomitant changes in GRPR expression . - pubmed
Furthermore , CRISPR - Cas9 - mediated astrocyte - selective in vivo editing of a gene encoding lipocalin-2 ( LCN2 ) , an astrocytic factor implicated in chronic itch , suppressed increases in GRP - induced excitation of GRPR+ neurons , repetitive scratching , and skin damage in mice with contact dermatitis . - pubmed
In addition , EEF2 , RPL26L1 , RPLP0 , PRPF8 , LSM3 , DHX9 , RSRC1 , and AP2B1 might be therapeutic targets for MDD . - pubmed
Although the mutation analysis performed on DNA isolated from blood cells and progressed lesion samples confirmed the tumor to be germline BRCA wild - type , cisplatin monotherapy was administered based on the increasing evidence of safety and efficacy of platinum for breast cancer . - pubmed
Serological tests revealed asymptomatic anemia and leukopenia , elevated liver enzymes , and positive antinuclear antibodies ( ANA ) and anti - SSb / La antibodies . - pubmed
Cathepsin S is an emerging marker for ovarian cancer . - pubmed
Under optimized conditions , in terms of pH and receptor concentration , both biosensors have linear response ranges between LOQ ( 0.14 ng mL-1 ) and 2.5 ng mL-1 , which is suitable for the determination of Cath S in blood plasma samples of ovarian cancer patients and healthy individuals , after corresponding dilution with 0.15 M PBS buffer . - pubmed
The biosensors were validated by the determination of Cath S in series of plasma from ovarian cancer patients and healthy volunteers using both biosensors and ELISA , giving Pearson coefficients close to 1 . - pubmed
Plasma Cath S concentration can be used as an ovarian cancer marker , in view of the highly elevated concentrations detected . - pubmed
Increases in pseudouridine excretion suggest increased tumor transfer ribonucleic acid turnover ; in addition , for the methylated nucleosides , higher than normal values may reflect enhanced transfer ribonucleic acid methylase activity of the neoplastic cells . - pubmed
These analyses plus morphologic and biochemical data support the hypothesis that VOD is caused by cytoreductive injury to hepatocytes and endothelium in zone three of the liver acinus , and in turn strongly influenced by factors which induce the release of tumor necrosis factor - alpha ( TNF - alpha ) leading to enhancement or activation of coagulation with obstruction of hepatic sinusoids and venules . - pubmed
Use of the TNF - alpha blocker , pentoxifylline , has also shown promise in lessening VOD . - pubmed
A statistical model which predicts patients likely to have an unfavorable outcome from VOD has been used to select premorbid patients for promising new therapeutic modalities , such as recombinant tissue plasminogen activator . - pubmed
Studies on two types of glutaminase in normal and tumour bearing mice . - pubmed
The isolation of these lymphokines should offer new insights into macrophage receptor - mediated endocytosis , and may yield substances useful in preventing foam cell formation in atherosclerosis . - pubmed
With regard to side effects , diarrhea developed in 4 cases and eosinophilia in 6 cases , abnormal simultaneous increases in GOT and GPT in 1 case and 1 case each for abnormal values in LDH and BUN were seen in the clinical test values . - pubmed
The occurrence of recurrent bacterial infections , neutrophil motility dysfunction and normal expression of beta 2 integrins ( CD18 ) in two unrelated children suggested an as yet undescribed adhesion deficiency . - pubmed
The fact that both children exhibited the rare Bombay blood group and were Lewis negative , each involving carbohydrates with different fucose linkages , suggested a possible defect in the fucose - containing ligand for E - and P - selectin , sialyl Lewis X ( SLe ( x ) ) . - pubmed
The observation that the neutrophils did not bind to recombinant E - selectin and purified P - selectin confirmed the SLe ( x ) deficiency as the basis for adhesion deficiency . - pubmed
Low binding of fucose - specific lectins to the patients ' B lymphocytes transformed with Epstein - Barr virus was observed , while the binding of mannose - specific lectins was normal , providing further evidence for a general fucose deficiency as the primary defect . - pubmed
The existence of the patients and their deficiency emphasizes the essential role of the endothelial cell selectins and their ligand , SLe ( x ) , in recruitment of neutrophils to sites of infection . - pubmed
Gene regulation of beta-1 - adrenergic receptor in genetically hypertensive rats . - pubmed
Relation of epidermal growth factor receptor concentration to growth of human esophageal cancer cell lines . - pubmed
The relation between the concentration of epidermal growth factor ( EGF ) receptor and the effects of EGF on cell proliferation were studied using 16 newly established human esophageal cancer cell lines . - pubmed
[ The diagnostic values of serum determinations of troponin T in acute ischemic cardiopathy ] . - pubmed
In addition , alterations in the glycosylation of IgG associated with rheumatoid arthritis were directly monitored . - pubmed
RER+ putative endometrial precancers ( atypical endometrial hyperplasias ) progress to RER+ carcinomas , which retain some of the altered microsatellites acquired in earlier precursor stages . - pubmed
Eighty - eight selected clinical isolates of Serratia marcescens , representing 27 putative outbreaks of nosocomial cross - infection encountered during 1980 - 1995 , were tested comparatively by bacteriocin typing , carbon source assimilation tests , serotyping ( O and H antigens ) , and restriction pattern ( RFLP ) analysis of restriction cleaved ( SpeI , XbaI ) genomic DNA fragments after pulsed - field gel electrophoresis ( PFGE ) . - pubmed
We will discuss our work suggesting that both CD4 and CD8 cells specific for different TCR determinants on the V beta 8.2 chain are involved in the regulation of MBP - specific CD4 T cells mediating experimental autoimmune encephalomyelitis . - pubmed
Genetic characterization of the nef gene from human immunodeficiency virus type 1 group M strains representing genetic subtypes A , B , C , E , F , G , and H. Most efforts to characterize sequence variation of HIV isolates has been directed toward the structural envelope gene . - pubmed
Interferon - alpha2a reduces MRI disease activity in relapsing - remitting multiple sclerosis . - pubmed
Norwegian Study Group on Interferon - alpha in Multiple Sclerosis . - pubmed
OBJECTIVE : To evaluate the efficacy and safety of interferon - alpha2a ( IFN - alpha2a ) in relapsing - remitting MS ( RRMS ) . - pubmed
BACKGROUND : Several immune - modulating therapy regimens of IFN - alpha have shown varying results in MS . - pubmed
Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer ' s disease brain . - pubmed
Proliferating cell nuclear antigen expression in Wilms ' tumor : a comparative study of pre- and post - chemotherapy specimens . - pubmed
A total of 36 Wilms ' tumors were immunohistochemically analyzed for proliferative ( proliferating cell nuclear antigen - labeling ) index ( PI ) with special reference to the effect of preoperative chemotherapy on the proliferative potential of tumors and differences in PI according to the histologic components ( epithelial , blastemal and stromal ) . - pubmed
We have previously demonstrated that the protein encoded by the retinoblastoma susceptibility gene ( Rb ) functions as a regulator of transcription by RNA polymerase I ( rDNA transcription ) by inhibiting UBF - mediated transcription . - pubmed
Four different genes , the amyloid precursor protein , apolipoprotein E , and presenilins 1 and 2 have been implicated in the etiology of familial AD . - pubmed
MOv18 antibody binds the membrane folate receptor highly expressed on ovarian carcinoma cells . - pubmed
Although induction of T cell responses to fed Ag ( oral tolerance ) is thought to happen within the organized lymphoid tissue of the gut , we found that mice lacking Peyer 's patches , B cells , and the specialized Ag - handling M cells had no defect in the induction of T cell responses to fed Ag , whether assayed in vitro by T cell proliferation or cytokine production , or in vivo by delayed - type hypersensitivity or bystander suppression against mycobacterial Ags in CFA . - pubmed
Factor VII deficiency is a serious , potentially lethal disorder of blood coagulation caused by a defect in hepatic factor VII synthesis . - pubmed
During papillomavirus infection , the E5 protein localizes in the cell Golgi apparatus and other endomembrane compartments . - pubmed
Cell viability and cytotoxicity were assessed by dimethylthiazolyldiphenyltetrazolium bromide ( MTT ) testing and quantification of lactate dehydrogenase . - pubmed
In the Danish cohort ( n = 306 ) of the Early Postmenopausal Intervention Cohort ( EPIC ) Study ( n = 1609 ) of oral alendronate ( ALN ) for prevention of postmenopausal osteoporosis , bone markers ( urine C - telopeptides of type I collagen ( uCTX ) , urine N - telopeptide cross - links of type I collagen ( uNTX ) , serum total osteocalcin measured by ELISA [ total OC ( ELISA ) ] , and serum total osteocalcin measured by RIA [ total OC ( RIA ) ] ) were measured at 6 - month intervals . - pubmed
Vascular endothelial growth factor assessment in different blood fractions of gastrointestinal cancer patients and healthy controls . - pubmed
Vascular endothelial growth factor ( VEGF ) is known to play a central role in tumour angiogenesis . - pubmed
The aims of this pilot study were to assess VEGF in blood compartments of 16 healthy control volunteers and 56 gastrointestinal cancer patients , prospectively collected , to identify the most suitable blood fraction for the determination of VEGF and to evaluate its possible clinical - biological significance . - pubmed
The best differentiation between healthy control volunteers and cancer patients in VEGF level was seen for P - APRCTAD ( mean value : 278 pg / ml vs 77 pg / ml ; p=0.0036 by t - test ) . - pubmed
Patients were evaluated for survival , quality of life , liver function , tumor mass , toxicity related to the treatment and retinoid receptors in liver biopsies . - pubmed
In addition to the diagnostic criteria for APS a heterozygous factor V Leiden mutation was found in this patient , which may be a contributing risk factor for cerebral ischemia . - pubmed
Editorial : HRPT2 in parathyroid cancer : a piece of the puzzle . - pubmed
However , additional comprehensive studies are required to further validate the technique and allow its entrance in mainstream diagnostic use , particularly for non - IgE - mediated hypersensitivity . - pubmed
Transgenic overproduction of murine 60 kDa heat shock protein in the liver does not prevent type I diabetes in NOD mice . - pubmed
Telomerase activity in disseminated prostate cancer cells . - pubmed
OBJECTIVE : To analyse telomerase activity in disseminated prostate cancer cells isolated from bone marrow aspirates taken from men with localized prostate cancer before radical prostatectomy ( RP ) . - pubmed
Telomerase activity in the 35 samples was not significantly associated with Gleason score , preoperative prostate - specific antigen level , tumour stage , or surgical margin status . - pubmed
Compared to tissue staining , where telomerase is detected in 80 - 90 % of samples , we found lower rates of telomerase activity in the disseminated tumour cells ( 49 % ) . - pubmed
Telomerase - negative cells might provide information about cell dormancy , as telomerase is a marker of cell proliferation in immortal and cancer cells . - pubmed
Metalloproteinases ( MMPs ) are responsible by remodeling ECM in many neuromuscular disorders . - pubmed
Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small - bowel mucosal transglutaminase 2 - specific IgA deposits . - pubmed
BACKGROUND : In celiac disease gluten , the disease - inducing toxic component in wheat , induces the secretion of autoantibodies which are targeted against transglutaminase 2 ( TG2 ) . - pubmed
Since the mucosal autoantibodies disappear slowly after a gluten - free diet , our aim was to establish whether autoantibody secretion to organ culture supernatants in treated celiac disease patient biopsies is related to the duration of the diet and further to the pre - existence of mucosal TG2 - specific IgA deposits in the cultured biopsy samples . - pubmed
RESULTS : In the organ culture system conducted with biopsies derived from treated celiac disease patients , gliadin induced secretion of autoantibodies to culture supernatants , reduced epithelial cell height and increased the density of lamina proprial CD25 + cells . - pubmed
However , these changes could be demonstrated only in biopsies from short - term treated celiac disease patients , where the small - intestinal mucosal TG2 - specific IgA autoantibody deposits were still present . - pubmed
CONCLUSION : Our results show that studies focusing on the toxic effects of gliadin in the organ culture system should be carried out with biopsy samples from short - term treated celiac disease patients who are likely still to have mucosal IgA deposits present . - pubmed
Endonuclease G expression in thalamic reticular nucleus after global cerebral ischemia . - pubmed
Endonuclease G is a mitochondrial enzyme , known to be translocated to the nucleus after transient focal cerebral ischemia and contribute to DNA degradation . - pubmed
The purpose of this study was to identify if Endonuclease G was expressed in the cell nucleus of parvalbumin(+ ) GABA'ergic neurons in relation to cell death after global cerebral ischemia in the thalamic reticular nucleus . - pubmed
Eosinophilic neurons and vacuolization of the cytoplasm in parvalbumin(+ ) neurons were observed 2 days after ischemia . - pubmed
Endonuclease G immunoreactivity increased in the cytoplasm 12 h after ischemia and was translocated to the nucleus of parvalbumin(+ ) neurons after 24 h. In the nucleus of astroglia , Endonuclease G was expressed after 2 days with an apoptotic - like morphology and the number of Endonuclease G - expressing astroglia increased during the later time points . - pubmed
In conclusion , this study has identified that Endonuclease G is translocated from the cytoplasm to the nucleus of neurons and expressed with apoptotic - like morphology in the nucleus of astroglia in the thalamic reticular nucleus after global cerebral ischemia . - pubmed
A quantitative inverse relationship between connexin32 expression and cell proliferation in a rat hepatoma cell line . - pubmed
[ Study on the progress of the mechanism of TGF - beta in the scarring and the effect of TCM ] . - pubmed
Transforming growth factor ( TGF - beta ) plays a central role in wound healing and scarring . - pubmed
TCM can reduce the expression of TGF - beta , resistance of fibrosis , so that lighten the development of scar . - pubmed
This article reviewed the mechanism of TGF - beta in the scarring and TCM can decrease the development of scar effected by TGF - beta . - pubmed
Increased urokinase - type plasminogen activator receptor and epidermal growth factor receptor in serum of patients with prostate cancer . - pubmed
PURPOSE : Prostate cancer cell motility and invasion have been linked to the up - regulated signaling of epidermal growth factor receptor and urokinase - type plasminogen activator receptor . - pubmed
We analyzed the expression of serum urokinase - type plasminogen activator receptor and epidermal growth factor receptor in the serum of patients with clinical suspicion of prostate cancer to evaluate the possible role as prostate cancer markers . - pubmed
RESULTS : The 30 patients with prostate cancer had significantly higher levels of serum urokinase - type plasminogen activator receptor and epidermal growth factor receptor in comparison to those without prostate cancer but not significantly higher levels of prostate specific antigen . - pubmed
Urokinase - type plasminogen activator receptor and epidermal growth factor receptor levels closely correlated in the serum of patients with prostate cancer . - pubmed
ROC analysis revealed that serum epidermal growth factor receptor had 93.3 % sensitivity and 98 % specificity for detecting prostate cancer at a cutoff of 67.9 ng / ml . - pubmed
CONCLUSIONS : The measurement of urokinase - type plasminogen activator receptor and epidermal growth factor receptor in the serum of patients with clinical suspicion of prostate cancer might provide clinically relevant information on the state of the prostate gland . - pubmed
Measuring serum epidermal growth factor receptor could help predict which patients have prostate cancer , while serum urokinase - type plasminogen activator receptor over expression seems to be related to tumor extraprostatic spread . - pubmed
The effects of the opiate receptor antagonist naloxone were tested on neurohypophyseal VP release during dehydration , ethanol administration and sulphated cholecystokinin octapeptide ( CCK-8S ) application , assuming that the inhibition of pituitary OT release by endogenous opioids increases as neurohypophyseal VP output increases . - pubmed
The data indicate that opioid peptides co - released with VP ( like dynorphin ) may be responsible for cross - inhibition of OT release during dehydration . - pubmed
Carotid atherosclerosis progression and ACAT inhibition . - pubmed
micRo - manageMeNT of MYC during hypoxia . - pubmed
Comparison of the post - meal glucose response to different insulin bolus waveforms in insulin pump- and pre - meal pramlintide - treated type 1 diabetes patients . - pubmed
CONCLUSIONS : For currently available insulin pump bolus waves , SQ and MC may be least likely to cause hypoglycemia in pramlintide - treated patients . - pubmed
This effect , or a sid-1(- ) background , can be used to uncover neuronal defects for lethal genes . - pubmed
PARTICIPANTS : Sixty - nine individuals ( 41 women , 28 men ; mean age 77.78 years , standard deviation 6.32 , range = 56 - 89 ) with a diagnosis of AD or mixed AD and vascular dementia and a Mini - Mental State Examination score of 18 or above , and receiving a stable dose of acetylcholinesterase - inhibiting medication . - pubmed
Anti - DLL4 , a cancer therapeutic with multiple mechanisms of action . - pubmed
Because of the importance of Notch signaling in stem cell biology , DLL4 has been investigated for its role in the maintenance and proliferation of cancer stem cells ( CSC ) . - pubmed
Preclinical studies have highlighted that both anti - CSC and anti - angiogenic activities contribute to its anti - tumor efficacy , and have supported the clinical development of anti - DLL4 antibody for the treatment of cancer . - pubmed
This study examined viral replication , cytotoxicity and cytokine production in cultures of primary AECs from children compared with responses to RSV infection in an immortalised epithelial cell line and to those from infants with RSV bronchiolitis . - pubmed
METHODS : RSV replication , proinflammatory cytokine responses and cytotoxicity in RSV - infected primary AEC cultures derived from bronchial brushings from the lungs of children were compared with those seen in BEAS-2B cultures , as well as AECs and bronchoalveolar lavage fluid collected from children with and without RSV bronchiolitis . - pubmed
RESULTS : Viral replication , cytotoxicity and inflammatory cytokine production were greater in primary AEC cultures than in BEAS-2B cells . - pubmed
Some primary AEC culture immunological responses , such as interleukin 8 , were similar in magnitude to those seen in clinical samples from the lungs of children with RSV bronchiolitis . - pubmed
DISCUSSION : The real - time PCR is a rapid and reliable method for detecting gene polymorphisms on the AGT M235 T , the A ( -6 ) G and A ( -20 ) C. CONCLUSION : this method of real - time PCR is a reliable genetic test , which is fast and cheap and can be used in practice to study particular polymorphisms of AGT gene associated with cardiovascular disease . - pubmed
BRAF inhibitors and melanoma . - pubmed
Selective BRAF inhibitors have recently emerged as a new standard treatment for patients with metastatic melanoma harboring activating BRAF mutations . - pubmed
Over - expression of anti - apoptotic BCL2 has been reported in chronic lymphocytic leukaemia ( CLL ) , but targeting BCL2 alone did not yield appreciable clinical results . - pubmed
Lenalidomide , an immunomodulator , is clinically effective in CLL and can enhance the anti - CLL effects of CD20 targeting monoclonal antibody , rituximab . - pubmed
Here , we investigated the mechanism of immune - directed killing of lenalidomide in CLL and evaluated if concurrent targeting of CD20 and BCL2 can enhance this effect . - pubmed
This effect was further enhanced with pre - treatment of tumour cells with AT-101 ( a BH3 mimetic that functions as BCL2 antagonist ) . - pubmed
Consistent with previous reports on ephrin - B2 induction in some epithelial tumors and tumor - associated vasculatures , EC8 specifically detected ephrin - B2 in tumors as well as the vasculature within and outside of the tumors . - pubmed
These results indicate that Comp.1 and Comp.2 have neurotrophic effects , and have the potential for disease modification in depression and dementia . - pubmed
By functional analysis of DeltaMoatg1 and DeltaMoatg4 mutants , we demonstrate that infection - associated nuclear degeneration in M. - pubmed
Previous studies with glioma cell lines such as NG108 - 15 cells attributed morphine - induced gene expression to the activation of the cAMP - responsive element binding protein ( CREB ) . - pubmed
Baseline platelet counts between 50,000 and 100,000 / mul independently predicted bleeding [ adjusted HR 2.89 ( 1.76 , 4.73 ) p & lt ; 0.001 ] as did esophageal varices , hemoglobin & lt;= 9.9 g % , and INR 1.4 - 2.0 . - pubmed
The pharmacokinetic studies indicated that KCN1 could be detected in all of the tissues examined , most for at least 24 h. In conclusion , our preclinical data indicate that KCN1 is a potential therapeutic agent for pancreatic cancer , providing a basis for its future development . - pubmed
In the following editorial , we will briefly describe new classes of potential bronchodilators including : novel PDE inhibitors , natural phytotherapeutics , bitter taste receptor ligands , and chloride channel modulators , which have the potential to be used alone or in combination with existing bronchodilators to reverse acute airway obstruction in the future . - pubmed
We used the UC rat model by immunological sensitization combined with local 2 , 4 , 6 - trinitrobenzene sulfonic acid ( TNBS ) in 50 % ethanol enema , observed dynamically animal general state and body weight , examined the histological and functional changes in the colon , lung , liver , and kidney tissues , and detected microvascular endothelium response towards inflammation characterized with the expression of iNOS , TXB2 , P - selectin , ICAM-1 , and vascular endothelial growth factor A ( VEGF - A ) in the colon and lung tissue . - pubmed
Single nucleotide mutations in the iduronate 2 - sulfatase ( IDS ) gene at Xq28 most commonly cause Hunter syndrome while a CGG expansion in the FMR1 gene at Xq27.3 is associated with Fragile X syndrome . - pubmed
CASE PRESENTATION : We describe the clinical , molecular and biochemical evaluations of a four year - old female patient with global developmental delay and a hemizygous deletion of Xq27.3q28 ( 144,270,614 - 154,845,961 bp ) , a 10.6 Mb region that contains & gt;100 genes including IDS and FMR1 . - pubmed
A literature review revealed rare cases with similar deletions that included IDS and FMR1 in females with developmental delay , variable features of Hunter syndrome , and skewed X - inactivation of the normal X chromosome . - pubmed
Moreover , integrin beta1 , through its abilities to activate latent TGFbeta1 and promote collagen production through focal adhesion kinase / rac1 / nicotinamide adenine dinucleotide phosphate oxidase ( NOX)/reactive oxygen species ( ROS ) , is essential for dermal homeostasis , repair and fibrosis . - pubmed
The integrin beta1 - interacting protein CCN2 , a member of the CCN family of proteins , is induced by TGFbeta1 ; yet , CCN2 is not a simple downstream mediator of TGFbeta1 , but instead synergistically promote TGFbeta1 - induced adhesive signaling and fibrosis . - pubmed
Stress - inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein . - pubmed
Rescue of embryonic lethality in these mutants , by transgenic expression of the STI1 gene , supported a unique role for STI1 during embryonic development . - pubmed
At the cellular level , ischemia increased the secretion of STI1 from wild - type astrocytes by 3 - fold , whereas STI1 haploinsufficient mice secreted half as much STI1 . - pubmed
Interesting , extracellular STI1 prevented ischemia - mediated neuronal death in a prion protein - dependent way . - pubmed
Downregulation of miR-15a due to LMP1 promotes cell proliferation and predicts poor prognosis in nasal NK / T - cell lymphoma . - pubmed
In NNKTL tissues , we found that reduced miR-15a expression , which correlated with MYB and cyclin D1 expression , was associated with poor prognosis of NNKTL patients . - pubmed
These data suggest that downregulation of miR-15a , possibly due to LMP1 , implicates in the pathogenesis of NNKTL by inducing cell proliferation via MYB and cyclin D1 . - pubmed
Anaphylactic responses to histamine in mice utilize both histamine receptors 1 and 2 . - pubmed
Despite clinical use of both H1R and H2R blockers in the therapy for acute allergic reactions , there is little mechanistic evidence to support the necessity for blocking H2R , a receptor best characterized for its role in stomach acid production . - pubmed
METHODS : Here , we sought to define the necessity for histamine receptors in the pathology of anaphylaxis using H1R and H2R knockout ( KO ) mice , as well as a H1R / H2R double KO strain . - pubmed
RESULTS : In response to IgE - mediated systemic anaphylaxis , the symptoms and decreases in core body temperature observed in wild - type mice were reduced but not ablated in either H1R or H2R KO . - pubmed
Intravenous injection of histamine was sufficient to elicit these responses , and similar to IgE - mediated anaphylaxis , loss of both H1R and H2R was necessary for complete protection . - pubmed
CONCLUSION : Our data demonstrate definitively that both H1R and H2R participate in the immediate systemic responses during histamine - associated pathophysiology and mechanistically support the utility of H2R - blocking therapeutics in alleviating symptoms of anaphylaxis . - pubmed
For patients exposed to ERT , the magnitude of the CD4 + depletion peaked 6 months after their cancer diagnosis ( mean CD4 + drop at this time = -283 + - 370 cells / mm(3 ) ) . - pubmed
CONCLUSIONS : In PLHIV , cancer treatment increased the risk for prolonged CD4 + depletion and virological failure but had no impact on AIDS - related events when appropriate prophylaxes were implemented . - pubmed
This study reviews the clinical manifestations of fragile X - associated disorders as well as the spectrum of mutations of the fragile X mental retardation 1 gene ( FMR1 ) and the neurobiology of the fragile X mental retardation protein ( FMRP ) , and also provides an overview of the potential therapeutic targets and genetic counselling . - pubmed
It is believed that CGG repeat expansions in the premutation range ( 55 to 200 repeats ) elicit an increase in mRNA levels of FMR1 , which may cause neuronal toxicity . - pubmed
Aryl Hydrocarbon Receptor Activation Down - Regulates IL-7 and Reduces Inflammation in a Mouse Model of DSS - Induced Colitis . - pubmed
Aryl hydrocarbon receptor ( AHR ) is believed to control the chronic inflammation in the gut . - pubmed
Besides , interleukin-7 ( IL-7 ) is proved to be an important cytokine that activates mucosal inflammation in IBD . - pubmed
In this study , we investigated the function of 6 - formylindolo ( 3,2 - b ) carbazole ( Ficz ) , a ligand of AHR , on IL-7 , colitis , and IEL phenotypes . - pubmed
RESULTS : Ficz down - regulated epithelial - derived IL-7 expression in mice with DSS - induced colitis and ameliorated DSS - induced colitis . - pubmed
CONCLUSIONS : Ficz could down - regulate epithelial - derived IL-7 expression in mice with DSS - induced colitis and inhibit inflammation in the gastrointestinal tract of mice . - pubmed
AHR - related compounds might be the new and promising therapeutic medicaments for the treatment of patients with IBD . - pubmed
[ Effectiveness and safety of initiation of once - daily insulin detemir in Chinese patients with type 2 diabetes previously treated with different quantities of oral anti - diabetic drugs : subgroup analysis of the Chinese SOLVE Study ] . - pubmed
OBJECTIVE : To evaluate the effectiveness and safety on once - daily ( OD ) insulin detemir ( IDet ) in Chinese patients with type 2 diabetes mellitus ( T2DM ) who were treated with different types or combinations of oral anti - diabetic drugs ( OADs ) . - pubmed
Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells . - pubmed
Corrigendum to " GK-1 Improves the Immune Response Induced by Bone Marrow Dendritic Cells Loaded with MAGE - AX in Mice with Melanoma " . - pubmed
How Melanoma Resists PD-1 Blockade . - pubmed
Researchers at the University of California , Los Angeles , have shed light on mechanisms by which melanoma cells become resistant to PD-1 blockade with pembrolizumab . - pubmed
Antimetastatic effects of cordycepin mediated by the inhibition of mitochondrial activity and estrogen - related receptor alpha in human ovarian carcinoma cells . - pubmed
After 24 h treatment , cordycepin suppresses epithelial - mesenchymal transition and migration in ovarian carcinoma cells through inhibiting estrogen - related receptor ( ERR )- alpha . - pubmed
EZH2 is a potential therapeutic target for H3K27M - mutant pediatric gliomas . - pubmed
Nearly 80 % of DIPGs harbor mutations in histone H3 genes , wherein lysine 27 is substituted with methionine ( H3K27 M ) . - pubmed
Furthermore , we demonstrate that small - molecule EZH2 inhibitors abolish tumor cell growth through a mechanism that is dependent on the induction of the tumor - suppressor protein p16INK4A. - pubmed
Furthermore , we find a highly significant overlap between genes that retain H3K27me3 in the DIPG mouse model and in human primary DIPGs expressing H3K27M. - pubmed
Taken together , these results show that residual PRC2 activity is required for the proliferation of H3K27M - expressing DIPGs , and that inhibition of EZH2 is a potential therapeutic strategy for the treatment of these tumors . - pubmed
Immunomodulation of autoimmune arthritis by pro - inflammatory cytokines . - pubmed
Pro - inflammatory cytokines promote autoimmune inflammation and tissue damage , while anti - inflammatory cytokines help resolve inflammation and facilitate tissue repair . - pubmed
Studies conducted by others and us in experimental models of arthritis involving direct administration of IFN - gamma or TNF - alpha ; in vivo neutralization of the cytokine ; the use of animals deficient in the cytokine or its receptor ; and the impact of the cytokine or anti - cytokine therapy on defined T cell subsets have revealed paradoxical anti - inflammatory and immunoregulatory attributes of these two cytokines . - pubmed
Similar studies in other models of autoimmunity as well as limited studies in arthritis patients have also unveiled the disease - protective effects of these pro - inflammatory cytokines . - pubmed
Nevertheless , the realization that pro - inflammatory cytokines can also be immunoregulatory offers a new perspective in fully understanding the pathogenesis of autoimmune diseases and in designing better therapies for controlling them . - pubmed
P2X7 receptor antagonism : Implications in diabetic retinopathy . - pubmed
Recently , an important link between P2X7 receptor ( P2X7R ) and inflammation has been demonstrated indicating this receptor as potential pharmacological target in DR . - pubmed
As an in vitro model of early diabetic retinopathy , human retinal pericytes were exposed to high glucose ( 25mM , 48h ) that caused a significant ( p<0.05 ) release of IL-1beta and LDH . - pubmed
Overall , our findings suggest that the P2X7R represents an attractive pharmacological target to manage the early phase of diabetic retinopathy , and the compound JNJ47965567 is a good template to discover other P2X7R selective antagonists . - pubmed
SUMMARY : A 62 - year - old woman with a grade 1 metastatic pancreatic neuroendocrine tumor ( pNET ) developed bilateral lower extremity edema and pain approximately 4 months after initiation of treatment with everolimus , an inhibitor of mammalian ( or mechanistic ) target of rapamycin ( mTOR ) . - pubmed
A hypothesized mechanism for everolimus - induced bone pain includes marrow edema and hyperemia from reduced intraosseous perfusion , which have been previously reported in association with mTOR inhibitor use . - pubmed
PrPSc ( scrapie isoform of the prion protein ) prions are the infectious agent behind diseases such as Creutzfeldt - Jakob disease in humans , bovine spongiform encephalopathy in cattle , chronic wasting disease in cervids ( deer , elk , moose , and reindeer ) , as well as goat and sheep scrapie . - pubmed
Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia . - pubmed
We have thus decided to study obesity in patients and to use the mouse model to evaluate if soluble FGFR3 therapy , an innovative treatment approach for achondroplasia , could also impact the development of this significant complication . - pubmed
These results were validated in a murine model of achondroplasia ( Fgfr3ach/+ ) where similar visceral adiposity was observed . - pubmed
Glucose , insulin or lipid levels remained low , without the development of diabetes . - pubmed
Very interestingly , in achondroplasia mice treated with soluble FGFR3 during the growth period ( from D3 to D22 ) , the development of these metabolic deregulations was prevented in adult animals ( between 4 and 14 weeks of age ) . - pubmed
These results suggest that achondroplasia induces an uncommon metabolism of energy , directly linked to the FGFR3 mutation . - pubmed
In this context , sFGFR3 proved to be a promising treatment for achondroplasia by normalizing the biology at different levels , not only restoring bone growth but also preventing the atypical visceral obesity and some metabolic deregulations . - pubmed
A 36 - year - old woman with JIA who was treated with tocilizumab targeting interleukin-6 ( IL-6 ) receptor underwent ABO - incompatible kidney transplantation ( ABOi KTx ) . - pubmed
Both serum IL-6 and soluble IL-6 receptor levels were markedly decreased , suggesting that multitargeted immunosuppression for ABOi KTx induced long - term clinical remission of JIA through inhibition of the IL-6 pathway . - pubmed
, Lynch syndrome ) , such as MSH6 ( 4.8 % vs. 1.2 % , p = .005 ) , MSH2 ( 2.7 % vs. 0.0 % , p = .004 ) , POLE ( 1.6 % vs. 0.0 % , p = .008 ) , NF1 ( 5.9 % vs. 0.5 % , p & lt ; .001 ) , SMAD4 ( 14.3 % vs. 8.3 % , p = .024 ) , and BRCA2 ( 3.7 % vs. 0.5 % , p = .002 ) . - pubmed
ADAR1 - mediated RNA - editing of 3'UTRs in breast cancer . - pubmed
BACKGROUND : Whole transcriptome RNA variant analyses have shown that adenosine deaminases acting on RNA ( ADAR ) enzymes modify a large proportion of cellular RNAs , contributing to transcriptome diversity and cancer evolution . - pubmed
Despite the advances in the understanding of ADAR function in breast cancer , ADAR RNA editing functional consequences are not fully addressed . - pubmed
In addition , tumors from the BRCA TCGA cohort show a 24 % increase in editing over normal breast samples when looking at 571 well - characterized UTRs targeted by ADAR1 . - pubmed
Basal - like subtype breast cancer patients with high level of ADAR1 mRNA expression shows a worse clinical outcome and increased editing in their 3'UTRs . - pubmed
Interestingly , editing was particularly increased in the 3'UTRs of ATM , GINS4 and POLH transcripts in tumors , which correlated with their mRNA expression . - pubmed
We confirmed the role of ADAR1 in this regulation using a shRNA in a breast cancer cell line ( ZR-75 - 1 ) . - pubmed
CONCLUSIONS : Altogether , these results revealed a significant association between the mRNA editing in genes related to cancer - relevant pathways and clinical outcomes , suggesting an important role of ADAR1 expression and function in breast cancer . - pubmed
Cortical D2 dopamine receptor ( Drd2 ) have mostly been examined in the context of cognitive function regulation and neurotransmission modulation of medial prefrontal cortex by principal neurons and parvalbumin positive , fast - spiking , interneurons in schizophrenia . - pubmed
These results pave the way for a thorough re - examination of cortical D2 receptor functions , which could provide information about neuronal circuits involved in psychotic and mood disorders . - pubmed
Expression of amino acid transporter ( LAT1 and 4F2hc ) in pulmonary pleomorphic carcinoma . - pubmed
Amino acid transporters are necessary for tumor growth , metastasis , and survival of various neoplasms ; however , the clinicopathological significance of L - type amino acid transporter 1 ( LAT1 ) and 4F2 cell surface antigen ( 4F2hc ) in patients with pulmonary pleomorphic carcinoma ( PPC ) remainsunknown . - pubmed
The expression of LAT1 and 4F2hc , and Ki-67 labeling index were investigated using specimens of the resected tumors . - pubmed
LAT1 and 4F2hc were highly expressed in 35 % and 53 % of all patients ( n = 105 , P & lt ; .01 ) , 25 % and 48 % of patients with an adenocarcinoma component ( n = 48 , P = .02 ) , and 44 % and 58 % of patients with a nonadenocarcinoma component ( n = 57 , P = .18 ) , respectively . - pubmed
A high LAT1 expression was significantly related to advanced disease , lymphatic permeation , tumor cell proliferation , and 4F2hc expression . - pubmed
LAT1 is highly expressed in PPC , and high LAT1 expression can serve as a significant predictor linked to a worse prognosis in patients with PPC . - pubmed
Sex - Dependent Effects of Bmal1 - Deficiency on Mouse Cerebral Cortex Infarction in Response to Photothrombotic Stroke . - pubmed
Therefore , we studied infarction in cerebral neocortex of male and female mice with deletion of the clock gene Bmal1 ( Bmal1-/- ) after focal ischemia induced by photothrombosis ( PT ) . - pubmed
However , when sexes were analyzed separately 14 days after PT , infarct core was significantly larger in wild - type ( Bmal1+/+ ) female as compared to male Bmal1+/+ mice , and in female Bmal1+/+ , as compared to female Bmal1-/- mice . - pubmed
Alterations in beta - catenin , microsatellite instability , and HNF-1beta levels are independently associated with ovarian endometriosis - associated tumorigenesis . - pubmed
Alterations in beta - catenin ( encoded by CTNNB1 ) and microsatellite instability ( MSI ) , as well as changes in the expression levels of HNF-1beta and DNA mismatch repair ( MMR ) proteins were investigated in 50 OEmCas and 21 OCCCas with endometriotic lesions . - pubmed
Mutations of CTNNB1 were identified in 28 ( 56 % ) of the 50 OEmCa cases and 26 ( 41.9 % ) of the 62 coexisting endometriosis lesions . - pubmed
MSI - high ( H ) was observed in 7 ( 14.6 % ) of the 48 OEmCa and 14 ( 23.3 % ) of the 60 coexisting endometriosis , and was significantly associated with loss of MMR protein expression , but not CTNNB1 mutations . - pubmed
Nonidentical CTNNB1 status between 2 different epithelial lesions within endometriosis was observed in 8 of 10 informative endometriosis cases that had adjacent OEmCa . - pubmed
In contrast , high HNF-1beta expression was significantly associated with SLC3A1 expression , which plays a major role in HNF-1beta - triggered induction of reactive oxygen species in OCCCas , independent of abnormalities in both beta - catenin and MSI / MMR status . - pubmed
Finally , 4 inflammatory parameters associated with repeated hemorrhaging in endometriosis were significantly higher in endometriosis with MSI - high when compared with that with MSS , independent of both beta - catenin and HNF-1beta status . - pubmed
In conclusion , different molecular pathways including alterations in beta - catenin , MSI , and HNF-1beta levels may contribute to tumorigenesis in endometriosis - associated carcinoma . - pubmed
While it was long held that T cells were the primary mediators of multiple sclerosis ( MS ) pathogenesis , the beneficial effects observed in response to treatment with Rituximab ( RTX ) , a monoclonal antibody ( mAb ) targeting CD20 , shed light on a key contributor to MS that had been previously underappreciated : B cells . - pubmed
Neurexophilin and PC - esterase domain family member 4 ( NXPE4 ) and prostate androgen - regulated mucin - like protein 1 ( PARM1 ) as prognostic biomarkers for colorectal cancer . - pubmed
Neurexophilin and PC - esterase domain family member 4 ( NXPE4 ) and prostate androgen - regulated mucin - like protein 1 ( PARM1 ) were two outstanding independent overall survival ( OS ) and relapse - free survival ( RFS ) prognostic genes of CRC in TCGA database . - pubmed
We next verified the expression of NXPE4 and PARM1 messenger RNA ( mRNA ) levels were significantly lower in CRC tumor tissue than in the adjacent noncancerous tissue in our clinical samples , and NXPE4 mRNA expression level was related to the tumor location and tumor size , while PARM1 was related to tumor location , lymph nodes metastasis , and tumor size . - pubmed
This study demonstrated that NXPE4 and PARM1 might be two potential novel prognostic biomarkers for CRC . - pubmed
Furthermore , we analyzed the properties of ASLMN and discovered that six lncRNAs ( MSTRG.10603.16 , 5258.4 , 12799.3 , 5352.1 , 12022.1 , and 12250.4 ) were highly related to AS through topological analysis . - pubmed
GO and KEGG enrichment analysis indicated that lncRNA MSTRG.5258.4 may downregulate inducible co - stimulator to perform a downregulated role in AS through T cell receptor signaling pathway and downregulate THBS1 to conduct a upregulated function in AS through ECM - receptor interaction pathway . - pubmed
NE- or ARs agonists - induced SAP originated from unifocal ectopic foci with predominant localization in the region surrounding PV mouth , but not in the distal portions of a murine PV myocardium . - pubmed
Rescue of cognitive deficits in APP / PS1 mice by accelerating the aggregation of beta - amyloid peptide . - pubmed
Soluble oligomers formed during the process that causes beta - amyloid ( Abeta ) to aggregate into plaques are considered to have major neurotoxicity . - pubmed
By using cell experiments , we determined whether ZGM1 can inhibit the cytotoxicity of Abeta . - pubmed
Animal experiments showed that ZGM1 can significantly improve cognitive dysfunction and that Abeta plaque deposition in the brain tissue of mice in the drug - administered group was significantly increased . - pubmed
CONCLUSION : Our research suggests that promoting Abeta aggregation is a promising treatment method for AD and deserves further investigation . - pubmed
In humans , the ovarian tumor protease ( OTU ) subfamily of DUBs includes 16 members , most of which mediate cell signaling cascades . - pubmed
Even though WHO criteria define anemia as a hemoglobin serum concentration < 12 g / dL in women and < 13 g / dL in men , several authors propose different and specific cut - off values for the elderly . - pubmed
Relating to the molecular mechanism in Iron Deficiency Anemia ( IDA ) , hepcidin has a key role in iron homeostasis . - pubmed
Affinity - Enhanced Multimeric VEGF ( Vascular Endothelial Growth Factor ) and PlGF ( Placental Growth Factor ) Variants for Specific Adsorption of sFlt-1 to Restore Angiogenic Balance in Preeclampsia . - pubmed
An excess of placental expressed antiangiogenic soluble VEGF ( vascular endothelial growth factor )- receptor 1 ( soluble FMS - like tyrosine kinase 1 ) scavenges VEGF and PlGF ( placental growth factor ) , causing generalized endothelial dysfunction . - pubmed
In ex vivo adsorption experiments using serum samples from patients with preeclampsia , scVEGF multimers reduce sFlt-1 levels by 85 % and increase PlGF and VEGF levels by 20- and 9 - fold , respectively . - pubmed
We introduce the first VEGF - based highly efficient sFlt-1 apheresis system that is directly applicable in vivo due to utilization of inert agarose matrix , using a homomultimeric form of VEGF165 to restore the angiogenic balance in preeclampsia . - pubmed
The critical role of the innate immune system has been confirmed in driving local and systemic inflammation and the cytokine release storm in severe acute respiratory syndrome coronavirus 2 ( SARS - CoV-2 ) . - pubmed
This dysregulated immune response is focused on interferon ( IFN ) and complement activation , which are crucial for the development of metabolic inflammation , local lung tissue damage , and systemic multi - organ failure . - pubmed
IFNs control viral infections by inducing expression of IFN - stimulated genes ( ISGs ) that restrict distinct steps of viral replication . - pubmed
Therefore , in this review article , we propose the mechanism of SARS - CoV-2 - associated acute respiratory disease syndrome , and assess treatment options by considering IFNs and by targeting IFN - antagonist SARS - CoV-2 virulent gene products . - pubmed
Furthermore , we elaborate on the mechanism of the amplified complement - mediated inflammatory cytokine storm , and propose an antiviral and immunotherapeutic strategy against coronavirus disease 2019 ( COVID-19 ) . - pubmed
Enzymatic Activity of CD73 Modulates Invasion of Gliomas via Epithelial - Mesenchymal Transition - Like Reprogramming . - pubmed
Invasive growth of GSCs is in part associated with epithelial - mesenchymal - like transition ( EMT ) , a mechanism associated with CD73 in several cancers . - pubmed
Here , we show that CD73 regulates the EMT activator SNAIL1 and further investigate the role of enzymatic and non - enzymatic CD73 activity in GBM progression . - pubmed
Taken together , our data indicate that CD73 is an exciting novel target in GBM therapy . - pubmed
The main outcome variables included the percentage of necrotic area ( PNA ) in flap tissues , histopathological results , vascular endothelial growth factor ( VEGF ) immunohistochemical ( IHC ) staining , and nitrite concentrations . - pubmed
E - cadherin expression during the acidic FGF - induced dispersion of a rat bladder carcinoma cell line . - pubmed
The effects of pretreatment with atrial natriuretic factor ( ANF ) on the pressor responsiveness to injections of angiotensin II ( ANGII ) , arginine vasopressin ( AVP ) , and norepinephrine ( NE ) , as well as the effect of pretreatment with ANGII on the hypotensive responses to ANF injection were studied in conscious sheep . - pubmed
In contrast , infusion of AII had no effect on the immediate hypotensive response to ANF injection . - pubmed
CYP21B gene conversion and complete CYP21A gene deletion in congenital adrenal hyperplasia . - pubmed
Two main types of CGD are known , an X - linked form which is normally associated with the absence of cytochrome b558 , a component of the membrane - associated reduced nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase which generates superoxide and an autosomal recessive form , in which cytochrome b558 is present , caused by the deficiency of a cytosolic factor required to activate NADPH oxidase . - pubmed
Autoantibodies directed at the platelet membrane glycoprotein Ib ( GPIb ) can mediate a severe form of idiopathic thrombocytopenic purpura ( ITP ) . - pubmed
The DMId idiotype has been found in the plasma of several patients with ITP , usually in association with GPIb - specific autoantibodies . - pubmed
Recently , alpha recombinant interferon has been proposed as treatment for low grade NHL . - pubmed
The degree of abnormal immune function , as shown by abnormalities in immunoglobulin levels , immune complex activity and T - lymphocyte subsets , was correlated with the extent of lymphadenopathy . - pubmed
A similar pattern of immunologic abnormality was associated with seropositivity for HTLV - III antibody . - pubmed
Macular oedema frequently produces central vision loss and legal blindness , most commonly in non - insulin dependent diabetics . - pubmed
Other therapeutic modalities , such as hypophysectomy for severe retinopathy , remain controversial , while still others , such as rigorous blood glucose control and aldose reductase inhibitors , are currently under investigation . - pubmed
Serum tri - iodothyronine ( T3 ) , thyroxine ( T4 ) and thyroid - stimulating hormone ( TSH ) concentrations were measured in 50 postmenopausal patients with breast cancer receiving tamoxifen therapy . - pubmed
Estrogen and progesterone receptor content in breast tumor cytosols calculated with a pocket calculator . - pubmed
Streptozotocin diabetes also caused a decrease in the cross - linking of reparative collagen as judged by the ratio of breaking strengths of skin incisions before and after formalin fixation . - pubmed
Based upon experimental data and theoretical considerations we conclude Sz diabetes causes two defects in wound healing : a ) quantitatively ( reduction in reparative collagen accumulation ) and b ) qualitative reduction in the degree of cross - linking of reparative wound collagen . - pubmed
HLA - A , -B , and -DR associations in type I diabetes mellitus with onset after age forty . - pubmed
It remains to be convincingly demonstrated whether insulin - requiring , ketosis - prone , lean - at - onset , type I diabetics who develop their disease after age 40 have the same disease as the children with similar characteristics . - pubmed
One hundred forty white , insulin - using diabetics with onset of disease past age 40 yr and 268 normal white controls have thus far been analyzed for HLA type . - pubmed
In the group of patients who were lean - at - onset and/or ketosis - prone ( N = 54 ) , there was a significantly increased frequency of DR4 ( RR = 4.63 ; P less than 0.01 ) and significantly decreased frequency of DR2 ( RR = 0.18 ; P less than 0.05 ) after correction . - pubmed
DR4 was also significantly increased after correction ( RR = 5.72 ; P less than 0.25 ) in the subgroup who were both lean and ketosis - prone ( N = 23 ) . - pubmed
To our knowledge , this is the first such study in the United States , and the first demonstrating that late onset diabetics who are lean - at - onset and/or ketosis - prone exhibit HLA - DR antigen associations which are similar to early onset cases . - pubmed
Allogeneic bone marrow transplantation ( BMT ) involves cytokines not only in their capacity as hematopoietins but also as inducers of systemic inflammation after conditioning for BMT and during graft - versus - host disease ( GVHD ) . - pubmed
GVHD is , in fact , a paradigm disease of systemic cytokine dysregulation , and the onset of severe acute GVHD can be considered a " cytokine storm . " - pubmed
Advances in our understanding of the cytokine networks involved in BMT and GVHD should increase our ability to modify the complex interactions among cytokines and their cellular targets that lead to transplant - related morbidity . - pubmed
Out of 318 women studied , 104 ( 32.7 % ) were anaemic ( Hb levels & lt ; 10gm / dl ) . - pubmed
Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein . - pubmed
Biochemical and genetic studies show that abetalipoproteinemia is not a defect of lipid biosynthesis or of the apolipoprotein B gene . - pubmed
The angiotensinogen ( AGT ) locus on chromosome 1q4 has been related to hypertension in sibship linkage studies , association studies , and studies of angiotensinogen levels by genotype in three different populations ( Utah , France , Japan ) . - pubmed
Effect of hypoxia on insulin secretion by isolated rat and canine islets of Langerhans . - pubmed
Second - phase insulin secretion was reduced substantially by hypoxia . - pubmed
Perinatal hypothyroidism induced by methimazole treatment did not significantly alter the appearance of cerebral cortical G alpha o1 and G alpha o2 between days 1 and 22 postpartum . - pubmed
Improved perfusion with rt - PA and hirulog in a rabbit model of embolic stroke . - pubmed
We conducted a study using diffusion - weighted ( DWI ) and perfusion - weighted ( PWI ) magnetic resonance imaging ( MRI ) to evaluate the efficacy of thrombolysis in an embolic stroke model with recombinant tissue plasminogen activator ( rt - PA ) and hirulog , a novel direct - acting antithrombin . - pubmed
Significant cerebral hemorrhage was observed in one placebo , two rt - PA , and three rt - PA plus hirulog treated animals . - pubmed
One fatal systemic hemorrhage was observed in each of the rt - PA groups . - pubmed
We conclude that rt - PA plus hirulog improves cerebral perfusion but does not necessarily reduce cerebral injury . - pubmed
All had node positive breast cancer and randomization was stratified by estrogen receptor ( ER ) status . - pubmed
This phenomenon was seen predominantly for high risk breast cancer with low levels or no estrogen receptors in the primary tumor . - pubmed
High resolution crystal structure of a human tumor necrosis factor - alpha mutant with low systemic toxicity . - pubmed
A human tumor necrosis factor - alpha ( TNF - alpha ) mutant ( M3S ) with low systemic toxicity in vivo was designed , and its structures in two different crystal packings were determined crystallographically at 1.8 and 2.15 - A resolution , respectively , to explain altered biological activities of the mutant . - pubmed
Compared with wild - type TNF - alpha , it exhibits 11- and 71 - fold lower binding affinities for the human TNF - R55 and TNF - R75 receptors , respectively , and in vitro cytotoxic effect and in vivo systemic toxicity of M3S are 20 and 10 times lower , respectively . - pubmed
However , in a transplanted solid tumor mouse model , M3S suppresses tumor growth more efficiently than wild - type TNF - alpha . - pubmed
The low systemic toxicity of M3S appears to be the effect of the reduced and selective binding affinities for the TNF receptors , and the superior tumor - suppression of M3S appears to be the effect of its weak but longer antitumoral activity in vivo compared with wild - type TNF - alpha . - pubmed
Mutational inactivation of aminoacylase - I in a small cell lung cancer cell line . - pubmed
Although nonmutational mechanisms for low or undetectable ACYl enzymatic activity , protein , and mRNA expression are most frequently operant in SCLC , the demonstration of a mutation supports selection for ACYl inactivation . - pubmed
Serum anti - beta2 - glycoprotein I antibodies from patients with antiphospholipid antibody syndrome bind central nervous system cells . - pubmed
Sera from 20 patients with antiphospholipid syndrome ( APS ) , primary or secondary to systemic lupus erythematosus ( SLE ) , or with SLE , were assayed by immunoblot analysis for anti - beta2 - glycoprotein I antibodies ( abeta2 - GPI ) , and by indirect immunofluorescence ( IIF ) technique for reactivity with astrocyte and neuron cell lines and with histological sections of human brain biopsies and monkey cerebellum . - pubmed
This issue may be relevant to further evaluate the potential pathogenetic role of abeta2 - GPI in the CNS damage of APS - like conditions . - pubmed
Intestinal reperfusion injury is mediated by IgM and complement . - pubmed
This study examines the role of the alternative and classic pathways of complement and IgM in a murine model of intestinal ischemia - reperfusion . - pubmed
Wild - type animals , mice deficient in complement factor 4 ( C4 ) , C3 , or Ig , or wild - type mice treated with soluble complement receptor 1 were subjected to 40 min of jejunal ischemia and 3 h of reperfusion . - pubmed
Compared with wild types , knockout and treated mice had significantly reduced intestinal injury , indicated by lowered permeability to radiolabeled albumin . - pubmed
We conclude that intestinal ischemia - reperfusion injury is dependent on the classic complement pathway and IgM. - pubmed
L - deprenyl inhibits tumor growth , reduces serum prolactin , and suppresses brain monoamine metabolism in rats with carcinogen - induced mammary tumors . - pubmed
The objective of the present study was to investigate the effects of L - deprenyl , a monoamine oxidase - B ( MAO - B ) inhibitor , treatment on the development and growth of tumors and on the metabolism of catecholamines and indoleamine in the medial basal hypothalamus ( MBH ) and the striatum ( ST ) of rats bearing 7,12 - dimethylbenzanthracene ( DMBA)-induced mammary tumors . - pubmed
Treatment with 5.0 mg deprenyl decreased the tumor diameter , tumor number , and serum prolactin ( PRL ) level . - pubmed
These results suggest that the suppression of the development and growth of DMBA - induced mammary tumors by chronic deprenyl treatment may be mediated through alterations in the synthesis and metabolism of catecholamines and indoleamine in the MBH and inhibition of PRL secretion . - pubmed
Of the 243 CAD patients , 179 ( 74 % ) were positive by an ELISA method for Chlamydia pneumoniae antibodies IgG and 132 ( 54 % ) were positive for C. - pubmed
When IgG antibodies were considered , there was no significant difference between CAD patients and healthy controls ( OR = 1.29 , 95 % CI = 0.79 - 2.10 , p & gt ; 0.05 ) . - pubmed
In cases of positive IgA antibodies alone , there was a significant difference between CAD patients and healthy controls ( OR = 1.58 , 95 % CI = 1.01 - 2.4 , p = 0.029 ) . - pubmed
Synthesis and secretion of MCP-1 by dental follicle cells -- implications for tooth eruption . - pubmed
BACKGROUND : Mutations of the RET proto - oncogene co - segregate with multiple endocrine neoplasia type 2A. - pubmed
Interleukin-13 gene therapy reduces inflammation , vascularization , and bony destruction in rat adjuvant - induced arthritis . - pubmed
Adenoviral production of interleukin-13 ( IL-13 ) reduces levels of proinflammatory mediators in an explant model of RA synovial tissue in vitro . - pubmed
To assess this approach in an animal model of arthritis , we compared intra - articular injections of an adenovirus producing rat IL-13 ( AxCArIL-13 ) , a control virus , and rat ankles receiving phosphate - buffered saline ( PBS ) in rat adjuvant - induced arthritis ( AIA ) . - pubmed
We demonstrate that IL-13 levels are normally low in ankles throughout the course of rat AIA . - pubmed
We show that administration of AxCArIL-13 before arthritis onset significantly reduces ankle circumference , paw volume , bony destruction , the number of polymorphonuclear cells ( PMNs ) , the quantity of blood vessels , and levels of monocyte chemoattractant protein ( MCP )- 1 in ankles . - pubmed
When administered as a treatment to inflamed ankles , AxCArIL-13 decreases articular index scores , paw volumes , bony destruction , vascularization , tumor necrosis factor - alpha ( TNF - alpha ) levels , and the quantity of monocytes , lymphocytes , and PMNs . - pubmed
Thus , increasing IL-13 levels significantly ameliorates the course of rat AIA , suggesting that similar strategies for the treatment of human RA are worthy of further study . - pubmed
By using a comprehensive panel of monoclonal antibodies we identified at least one leukemia - associated aberrant immunophenotype ( LAIP ) in each patient . - pubmed
Six isolates of an unknown Gram - positive , catalase - negative , chain - forming , coccus - shaped organism isolated from ovine and caprine mastitis were characterized by phenotypic and molecular taxonomic methods . - pubmed
Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor - kappaB and activator protein-1 in inflammatory acne lesions in vivo . - pubmed
We report here that transcription factors nuclear factor - kappaB and activator protein-1 are activated in acne lesions with consequent elevated expression of their target gene products , inflammatory cytokines and matrix - degrading metalloproteinases , respectively . - pubmed
These elevated gene products are molecular mediators of inflammation and collagen degradation in acne lesions in vivo . - pubmed
[ Correlation between platelet count and CA-125 in ovarian cancer ] . - pubmed
In the thrombocytosis group , an average CA-125 level ( 913.5 U / ml ) was significantly higher ( p & lt ; 0.00001 ) then in the group with normal platelet count ( 103.7 U / ml ) . - pubmed
CONCLUSIONS : Platelet count and CA-125 levels do correlate in blood samples taken from ovarian cancer patients at the same time . - pubmed
Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model . - pubmed
PURPOSE : In this study , we investigated the antitumor efficacy of thrombospondin-1 three type 1 repeats ( 3TSR ) , the antiangiogenic domain of thrombospondin-1 , in comparison and in combination with gemcitabine , in an orthotopic pancreatic cancer model . - pubmed
Extensive necrotic areas were observed in tumors from 3TSR - treated mice , whereas tumors from gemcitabine and combinatorially treated mice were less necrotic than control tumors . - pubmed
CONCLUSION : 3TSR , the antiangiogenic domain of thrombospondin-1 , showed comparable antitumor efficacy to gemcitabine in a human pancreatic cancer orthotopic mouse model . - pubmed
We evaluated whether or not the elevated levels beta2 - microglobulin in CSF can be a useful marker for diagnosis of lymphoproliferative disorders in 108 patients with neurological diseases . - pubmed
A CSF to serum beta2 - microglobulin ratio greater than 1 was closely associated with intrathecal synthesis beta2 - microglobulin in CNS lymphoproliferative disorders . - pubmed
Elevation of CSF beta2 - microglobulin ratio is a sensitive marker of central nervous system disease activity by infiltrating lymphocytes in intracranial lymphomas ( 10/10 ) and paraneoplastic neurological syndromes ( 2/3 ) . - pubmed
HLA - B27 - associated acute anterior uveitis in the University Referral Centre in North Thailand : clinical presentation and visual prognosis . - pubmed
Although human leucocyte antigen ( HLA )- B27 - associated ankylosing spondylitis was reported in South East Asia , it is not known whether HLA - B27 - associated ocular disease is prevalent in Thailand . - pubmed
The clinical characteristics of HLA - B27 - associated AAU were similar to those published throughout the world ( unilaterality in 74 % , hypopyon in 31 % , recurrent AAU in 64 % ) . - pubmed
At least 15 % of the HLA B27 - positive group had radiological signs of ankylosing spondylitis . - pubmed
CONCLUSION : The prevalence of HLA - B27 in the population without uveitis in Thailand is about 10 % and clinical characteristics of HLA - B27 - positive AAU are similar to those reported in the west . - pubmed
In contrast with earlier reports , HLA - B27 - negative AAU in Thailand was associated with increased IOP and should be further studied . - pubmed
[ Hepatocellular carcinoma occurring after 11 year - long sustained viral response to interferon therapy for chronic hepatitis C ] . - pubmed
OBJECTIVE : To construct anti - CD20scFv / CD80 / CD28 / zeta recombinant gene modified T cells , test its effectiveness of eradicating CD20 + lymphoma cells and provide a probably new approach to tumor adoptive immunotherapy . - pubmed
The cytotoxicity and cytokine production of transduced T cells were determined by non - radio - activation cytotoxicity assay and ELISA respectively . - pubmed
It can specially kill CD20 positive lymphoma cells in vitro . - pubmed
Pompe disease , which results from mutations in the gene encoding the glycogen - degrading lysosomal enzyme acid alpha - glucosidase ( GAA ) ( also called " acid maltase " ) , causes death in early childhood related to glycogen accumulation in striated muscle and an accompanying infantile - onset cardiomyopathy . - pubmed
The efficacy of enzyme replacement therapy ( ERT ) with recombinant human GAA was demonstrated during clinical trials that prolonged subjects ' overall survival , prolonged ventilator - free survival , and also improved cardiomyopathy , which led to broad - label approval by the U.S. Food and Drug Administration . - pubmed
About 30 - 40 % of patients with insect venom allergy have IgE antibodies reacting with both honeybee and Vespula venom . - pubmed
This study should stimulate further research to determine the implication of altered IP in the disease pathophysiology of FM and CRPS . - pubmed
Earlier studies identified the dynorphin - kappa opioid receptor ( KOR ) system as a critical mediator of dysphoria - induced aversion after repeated stress exposure , but the molecular signaling mechanisms were not fully characterized . - pubmed
At the beginning and at the end of the study we recorded some clinical indicators such as BMI and WHR , some hormonal indicators such as testosterone , insulin , SHBG and DHEAS , as well as some metabolic indicators such as total cholesterol , triglycerides and HDL - C. RESULTS : We discovered a considerable reduction of 27,1 % in insulin and HOMA - IR ( 29,1 % ) , which indicates an improved insulin resistance . - pubmed
Gasdermin ( GSDM or GSDMA ) , expressed in the upper gastrointestinal tract but frequently silenced in gastric cancers ( GCs ) , regulates apoptosis of the gastric epithelium . - pubmed
Colony formation assay showed that GSDMB , closely related to GSDMA , has no cell - growth inhibition activity in gastric cancer cells , and that GSDMC and GSDMD , respectively , exhibit the activity with different strengths from that of GSDMA . - pubmed
In this study , we extend these results to describe the use of a humanized , high - expression , hybrid human / porcine fVIII transgene that is 89 % identical to human fVIII and was delivered by lentiviral vectors ( LVs ) to hematopoietic stem cells for gene therapy of hemophilia A. - pubmed
From these studies , we conclude that humanized high - expression hybrid fVIII transgenes can be utilized in gene therapy applications for hemophilia A to significantly increase fVIII expression levels compared to what has been previously achieved . - pubmed
Loss of endogenous interleukin-12 activates survival signals in ultraviolet - exposed mouse skin and skin tumors . - pubmed
UV - induced skin tumors of IL-12 KO mice had higher levels of PI3 K , p - Akt ( Ser(473 ) ) , p - ERK1 / 2 , p - p38 , NF - kappaB , and PCNA and fewer apoptotic cells than skin tumors of wild types . - pubmed
Dietary - induced hyperparathyroidism affects serum and gingival proinflammatory cytokine levels in rats . - pubmed
This study investigated the systemic and periodontal effects of dietary - induced hyperparathyroidism ( dHPT ) by evaluating serum and gingival proinflammatory cytokine levels . - pubmed
Serum cytokines were analyzed in the blood samples collected prior to periodontitis induction , whereas gingival cytokines were analyzed in the gingival supernatants of the four groups . - pubmed
CONCLUSION : The results suggested that increased serum proinflammatory cytokine production may be a complication of dHPT , and this may affect healthy and diseased periodontia by increasing gingival proinflammatory cytokine levels . - pubmed
More than 700 mutations have been described in 12 genes ( LQT1 - LQT12 ) involved in congenital long QT syndrome . - pubmed
In the case of a suspicious clinical presentation ( firm mass , nipple retraction ) and/or the presence of risk factors for breast cancer ( BRCA2 mutation , previous breast cancer ) , core needle biopsy always demonstrated malignancy . - pubmed
Chitin hydrolysate stimulates VEGF - C synthesis by MDA - MB-231 breast cancer cells . - pubmed
Up - regulation of VEGF - C ( vascular endothelial growth factor C ) , a most potent lymphangiogenic factor , is associated with inflammation and cancer metastasis . - pubmed
Hypersensitivity to thromboxane receptor mediated cerebral vasomotion and CBF oscillations during acute NO - deficiency in rats . - pubmed
CONCLUSION / SIGNIFICANCE : These results suggest that hypersensitivity of the TP - receptor - Rho - kinase signaling pathway contributes to the development of low frequency cerebral vasomotion which may propagate to vasospasm in pathophysiological states associated with NO - deficiency . - pubmed
Interleukin-30 : a novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine - induced liver injury . - pubmed
Here we establish the role of IL30 as a potent antiinflammatory cytokine that can inhibit inflammation - induced liver injury . - pubmed
In animal models , administration of IL30 by way of a gene therapy approach prevents and treats both IL12- , IFN - gamma- , and concanavalin A - induced liver toxicity . - pubmed
Likewise , immunohistochemistry analysis of human tissue samples revealed that IL30 is highly expressed in hepatocytes , yet barely expressed in inflammation - induced tissue such as fibrous / connective tissue . - pubmed
CONCLUSION : These novel observations reveal a novel role of IL30 as a therapeutic cytokine that suppresses proinflammatory cytokine - associated liver toxicity . - pubmed
DRDE / WH-02 showed better wound healing as evidenced by widespread re - epithelialization , homogenous fibroplasias well supported by the expression of transforming growth factor - alpha , endothelial nitric oxide synthase ( eNOS ) and fibroblast growth factor . - pubmed
Upregulation of interleukin 6 in DRDE / WH-02 - treated mice skin resulted in increased tissue leukocytosis and an early removal of tissue debris that initiated reparative process at faster rate compared to other groups . - pubmed
This study demonstrated that these MAbs could recognize CCV specifically and will be useful in the development of diagnostic methods for the detection of fish CCV infection . - pubmed
Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia . - pubmed
BACKGROUND : Levels of complement regulatory proteins ( CrP ) on the surface of red blood cells ( RBC ) decrease during severe malarial anaemia and as part of cell ageing process . - pubmed
It remains unclear whether CrP changes seen during malaria contribute to the development of anaemia , or result from an altered RBC age distribution due to suppressive effects of malaria on erythropoiesis . - pubmed
METHODS : A cross sectional study was conducted in the north - east coast of Tanzania to investigate whether the changes in glycosylphosphatidylinositol ( GPI)-anchored complement regulatory proteins ( CD55 and CD59 ) contributes to malaria anaemia . - pubmed
Levels of CD59 were lower in anaemic children , but these differences were not significant . - pubmed
CD55 , but not CD59 , levels correlated positively with the level of haemoglobin in anaemic children . - pubmed
CONCLUSION : The extent of CD55 loss from RBC of all ages early in the course of malarial anaemia and the correlation of CD55 with haemoglobin levels support the hypothesis that CD55 may play a causal role in this disorder . - pubmed
Pathologic assessment included volume of excision , subtype , size , distance from margin , grade , necrosis , multifocality , calcifications , and ER / PR status . - pubmed
AIMS : To examine the frequency of AGT and its outcome in prepubertal CF patients and the changes in glycemic and nutritional status and lung function over the preceding year . - pubmed
Among initial AGT patients , of 4 INDET : 2 developed IGT , 1 CFRD . - pubmed
CONCLUSIONS : The high frequency of AGT in prepubertal CF patients and their negative clinical impact supports the usefulness of an earlier glycemic screening . - pubmed
Spontaneous preterm delivery was found to be significantly associated with unmarried status ( cOR : 1.7;1.52 - 2.57 ) , baseline CD4 count & lt;200 cells / mm(3 ) ( cOR : 1.8 ; 1.16 - 2.99 ) , presence of opportunistic infection at delivery ( cOR : 2.2;1.23 - 3.57 ) , multiple pregnancy ( cOR 10.4 ; 4.24 - 26.17 ) , use of PI based triple ARV therapy ( eOR 10.2 ; 5.52 - 18.8 ) in the first trimester ( cOR 2.5 ; 1.77 - 3.52 ) on univariate analysis . - pubmed
A clinical - biological risk stratification model for resected gastric cancer : prognostic impact of Her2 , Fhit , and APC expression status . - pubmed
PATIENTS AND METHODS : Clinicopathological and molecular data ( expression of Cdx2 , Apc , beta - catenin , E - cadherin , Fhit , p53 , and human epidermal growth factor receptor-2 ( Her2 ) ; HER2 and TOPO2A gene copy number ; PIK3CA mutations ; microsatellite instability ) were correlated to cancer - specific / overall survival ( CSS / OS ) using a Cox model . - pubmed
At multivariate analysis , sex , stage , margins , location , nodes , Apc , and Fhit were independent predictors for CSS ; the same factors ( and age and Her2 , except Fhit ) predicted OS . - pubmed
CONCLUSIONS : A risk classification system comprising the immunohistochemical expression of three proteins ( Apc , Fhit , and Her2 ) and five clinicopathological parameters ( stage , resected nodes , margins , location , and sex ) accurately separates the resected gastric cancer patients into three classes of risk . - pubmed
10 days after the start of using spironolactone and dabigatran bleeding was marked with decrease in hemoglobin levels to 69 g / l , creatinine level increases to 3.6 mg / dL ( glomerular filtration rate by MDRD 18 ml / min/1,73 m2 ) , and potassium to 5.5 mEq/ l. Against the background of the abolition of drugs normalization of renal function was marked . - pubmed
A common mechanism is the overexpression of ATP - binding cassette ( ABC ) efflux transporters in cancer cells such as P - glycoprotein ( P - gp / ABCB1 ) , multidrug resistance - associated protein 1 ( MRP1 / ABCC1 ) and breast cancer resistance protein ( BCRP / ABCG2 ) that limit the exposure to anticancer drugs . - pubmed
In addition , ABC transporters such as P - gp , MRP1 and BCRP co - expressed in tumors show a broad and overlapped specificity for substrates and MDR modulators . - pubmed
Predictors of congestive heart failure after treatment with an endothelin receptor antagonist . - pubmed
BACKGROUND AND OBJECTIVES : The Avosentan on Time to Doubling of Serum Creatinine , End Stage Renal Disease or Death ( ASCEND ) trial tested the renoprotective effect of the endothelin receptor antagonist avosentan in patients with diabetes and nephropathy , but the study was terminated due to an excess of congestive heart failure ( CHF ) events in the avosentan arms , likely due to fluid retention . - pubmed
Furthermore , postrandomization changes between baseline and the first available measurement of body weight and hemoglobin were examined as potential clinical indicators of fluid retention for their relationship with CHF development . - pubmed
The body weight increase induced by avosentan was associated with CHF development ( P interaction=0.04 ) , whereas hemoglobin decrease was not ( P interaction=0.64 ) . - pubmed
CONCLUSIONS : In avosentan - treated patients , body weight increase , but not hemoglobin decrease , was associated with CHF development , indicating that close body weight monitoring could provide an early signal of CHF development in future trials with endothelin receptor antagonists . - pubmed
Concurrently , CNTs did not induce any intrinsic abnormal immune response or inflammation , as confirmed by normal cytokine levels and histological evaluations . - pubmed
BACKGROUND : Addition of catechol - O - methyltransferase inhibitors to a conventional levodopa / dopadecarboxylase inhibitor regimen improves motor symptoms in patients with Parkinson ' s disease . - pubmed
They often exhibit discrepancies with the primitive tumor , especially concerning the molecular basis of sensitivity / resistance to targeted therapies ( expression of HER2 and hormone receptors , mutations responsible for resistance to tyrosine - kinase inhibitors ) . - pubmed
Intravitreal anti - vascular endothelial growth factor for typical exudative age - related macular degeneration in eyes with good baseline visual acuity . - pubmed
PURPOSE : To investigate 12 - month treatment outcomes of anti - vascular endothelial growth factor therapy in eyes with typical exudative age - related macular degeneration with good baseline visual acuity . - pubmed
Diagnostic Values of Cerebrospinal Fluid T - Tau and Abeta42 using Meso Scale Discovery Assays for Alzheimer ' s Disease . - pubmed
BACKGROUND : Meso Scale Discovery ( MSD ) recently established electrochemiluminescence - based assays to measure cerebrospinal fluid ( CSF ) levels of total tau ( t - tau ) and amyloid - beta 1 - 42 peptide ( Abeta42 ) that can aid in the diagnosis of Alzheimer ' s disease ( AD ) . - pubmed
The deletion of the gene Hmox1 in mice leads to inadequate remodeling of spiral arteries and suboptimal placentation followed by intrauterine growth restriction ( IUGR ) and fetal lethality . - pubmed
A partial Hmox1 deletion leads to IUGR as well , with heterozygote and wild - type fetuses being born , but Hmox1 ( -/- ) significantly below the expected Mendelian rate . - pubmed
Similarly , HO-1 inhibition provokes hypertension in pregnant rats . - pubmed
Merlin expression , encoded by the NF2 gene , is lost in a majority of meningiomas , and merlin is a negative regulator of mTORC1 . - pubmed
The sst2 somatostatin receptor , targeted by octreotide , is highly expressed in meningiomas . - pubmed
Further , everolimus decreased cell viability of human meningiomas , but concomitantly , induced Akt activation , reducing the antiproliferative effect of the drug . - pubmed
Multiparity and insulin - treated GDM were exclusion criteria . - pubmed
CONCLUSION : It seems that aerobic training with vitamin D , due to the involvement of muscle mass and exposure to dynamic pressure on the bones and muscles , increased energy expenditure , stimulated insulin exudation and glucose homeostasis , decreased insulin resistance and improved the lipid profile in ovariectomized rats . - pubmed
CVD strains [ spontaneously hypertensive ( SH ) , SH stroke - prone ( SHSP ) , SHHF / Mcc heart failure obese ( SHHF ) , insulin - resistant JCR : LA - cp obese ( JCR ) and Fawn - Hooded hypertensive ( FHH ) ] were compared with normal strains [ Wistar , Sprague - Dawley ( SD ) and Wistar Kyoto ( WKY ) ] . - pubmed
The children with moyamoya syndrome presented with abnormal CD4 counts and raised viral loads . - pubmed
A novel PPARalpha agonist propane-2 - sulfonic acid octadec-9 - enyl - amide inhibits inflammation in THP-1 cells . - pubmed
Because PPARalpha activation is associated with inflammation control , we hypothesize that N15 may have anti - inflammatory effects . - pubmed
In particular , we assessed the production of chemokines , adhesion molecules and proinflammatory cytokines , three important types of cytokines that are released from monocytes and are involved in the development of atherosclerosis . - pubmed
In Vivo FRET Imaging of Tumor Endothelial Cells Highlights a Role of Low PKA Activity in Vascular Hyperpermeability . - pubmed
PKA activation with a cAMP analogue alleviated the tumor vascular hyperpermeability , suggesting that the low PKA activity in the endothelial cells may be responsible for the tumor - tissue hyperpermeability . - pubmed
Motesanib , a kinase inhibitor for VEGF receptor , activated tumor endothelial PKA and reduced the vascular permeability in the tumor . - pubmed
Notably , in cultured human umbilical vascular endothelial cells , VEGF activated PKA rather than decreasing its activity , highlighting the remarkable difference between its actions in vitro and in vivo These data suggested that the VEGF receptor signaling pathway increases vascular permeability , at least in part , by reducing endothelial PKA activity in the live tumor tissue . - pubmed
Breakage analysis revealed OS specific unstable regions in which well - known OS tumor suppressor genes , including TP53 , RB1 , WWOX , DLG2 and LSAMP are located . - pubmed
Docosanoids include neuroprotectin D1 ( NPD1 ) , which is decreased in the CA1 hippocampal area of patients with early - stage Alzheimer ' s disease ( AD ) . - pubmed
We summarize here how NPD1 elicits neuroprotection by up - regulating c - REL , a nuclear factor ( NF )- kappaB subtype that , in turn , enhances expression of BIRC3 ( baculoviral inhibitor of apoptosis repeat - containing protein 3 ) in the retina and in experimental stroke , leading to neuroprotection . - pubmed
Disease - causing variants were identified in MYO6 , CLN6 , LRBA , KCTD7 , and ARSB revealing a genetic diagnosis of a LD in 8 individuals from 5 families . - pubmed
MiR-146a-5p correlates with clinical efficacy in patients with psoriasis treated with the tumour necrosis factor - alpha inhibitor adalimumab . - pubmed
However , the role of GIP in peripheral artery disease remains unclear . - pubmed
The genetic deletion of GIP receptor ( GIPR ) led to exaggerated neointimal hyperplasia after transluminal femoral artery wire injury . - pubmed
Conversely , chronic GIP infusion suppressed neointimal hyperplasia and facilitated endothelial regeneration . - pubmed
Our findings imply the potential vascular benefits of multiple agonists targeting G protein - coupled receptors , including GIPR , which are under development for the treatment of type 2 diabetes . - pubmed
Detection of PrPres in peripheral tissue in pigs with clinical disease induced by intracerebral challenge with sheep - passaged bovine spongiform encephalopathy agent . - pubmed
H3K4me3 and Wdr82 are associated with tumor progression and a favorable prognosis in human colorectal cancer . - pubmed
Histone H3 trimethylation at lysine 4 ( H3K4me3 ) has been reported to modulate the expression of tumor - associated expression and be altered during the progression of several human cancers . - pubmed
An aim of the present study was to determine H3K4me3 and Wdr82 expression and their clinical significances in colorectal cancer ( CRC ) . - pubmed
Immunohistochemistry results demonstrated that the expression level of the H3K4me3 and Wdr82 were significantly decreased in CRC tissues compared with paired noncancerous tissues from 123 patients with CRC . - pubmed
Additionally , multivariate Cox regression analysis indicated that the low expression level of H3K4me3 or Wdr82 was associated with reduced overall survival ( OS , P<0.05 ) , and patients with a low H3K4me3 and Wdr82 expression had a significantly poorer outcome compared with patients with a high expression of H3K4me3 and Wdr82 ( P=0.0001 ) , suggesting that H3K4me3 and Wdr82 expression were independent factors for OS in patients with CRC . - pubmed
In conclusion , the decreased expressions of H3K4me3 and Wdr82 were associated with a poor prognosis in CRC . - pubmed
The combined expression of H3K4me3 and Wdr82 may serve as a novel prognostic marker for CRC . - pubmed
The main factor of ascites formation is renal sodium retention due to activation of the renin - angiotensin - aldosterone system and sympathetic nervous system by the reduced effective volume secondary to splanchnic arterial vasodilation . - pubmed
A serum - ascites albumin gradient of & gt;=1.1 g / dL indicates portal hypertension with an accuracy of approximately 97 % . - pubmed
Repeated large volume paracentesis plus albumin is the first line treatment , and liver transplantation is recommended in patients with refractory ascites . - pubmed
The high distribution of CB2 receptors in immune cells suggests their important role in the control of inflammation . - pubmed
Growing evidence offers this receptor as an attractive therapeutic target : selective CB2 agonists are able to modulate inflammation without triggering psychotropic effects . - pubmed
Bronchial epithelial cells produce CXCL1 in response to LPS and TNFalpha : A potential role in the pathogenesis of COPD . - pubmed
CXC chemokine ligand ( CXCL ) 1 is a neutrophil chemokine involved in the pathogenesis of COPD . - pubmed
MATERIALS AND METHODS : We measured sputum CXCL1 and CXCL8 levels in patients with COPD , asthma , and asthma - COPD overlap ( ACO ) , and compared them to those of patients with interstitial pneumonia ( IP ) . - pubmed
RESULTS : Sputum CXCL1 levels in COPD and ACO patients were higher than in IP patients , whereas sputum CXCL8 levels were not . - pubmed
CONCLUSIONS : Sputum CXCL1 levels is a potentially better diagnostic marker for COPD than sputum CXCL8 levels , which is explained by that CXCL1 production in bronchial epithelial cells is less affected by therapeutic anti - inflammatory agents than CXCL8 production . - pubmed
PATZ1 is required for efficient HIV-1 infection . - pubmed
Here , expression cloning with a cDNA expression library identified as an inhibitor of HIV-1 infection , a carboxy - terminally truncated form of human POZ / BTB and AT - hook - containing Zinc finger protein 1 ( PATZ1 ) , a transcriptional regulatory factor implicated in development and cancer . - pubmed
Knockdown or knockout of endogenous PATZ1 revealed a supportive role of PATZ1 in HIV-1 infection , but not in transduction with murine leukemia virus - based retroviral vector . - pubmed
More specifically , knockdown or knockout of PATZ1 impaired the viral cDNA synthesis but not the entry process and expression of two PATZ1 isoforms in PATZ1 - KO cells restored susceptibility to HIV-1 infection . - pubmed
These results indicate that PATZ1 plays an important role in HIV-1 infection . - pubmed
MATERIALS AND METHODS : In vivo HLJDT effects were investigated by determining the severity of dermatitis , which consisted of observing signs of skin lesions , visually and through haematoxylin and eosin ( HE ) staining , in mouse ears and dorsal skin , measuring serum levels of interleukin ( IL )- 1alpha , IL-1beta , IL-2 , IL-4 , IL-5 , IL-6 , interferon ( IFN )- gamma , the tumour necrosis factor ( TNF )- alpha , and determining the splenic index , number of splenic CD4+/CD8 + T - lymphocytes , as well as the phosphorylation levels of mitogen - activated protein kinases ( including MAPKs - p38 , ERK , and JNK ) , IkappaB - alpha , and nuclear factor kappa B ( NF - kappaB ) ( p65 ) within dermal lesions . - pubmed
Morphological changes in LPS - induced inflammation were observed under a microscope , and ELISA and qPCR assays were used to measure IL-1alpha , IL-1beta , IL-6 , and TNF - alpha expression levels . - pubmed
RESULTS : HLJDT could remarkably mitigate DNCB - induced AD - like lesion symptoms , alleviating inflammatory mediator infiltration in mouse ears and dorsal skin tissue , down - regulating serum expression levels of IL-1alpha , IL-1beta , IL-2 , IL-4 , IL-5 , IL-6 , IFN - gamma , and TNF - alpha , normalising the splenic CD4+/CD8 + T - lymphocyte ratio , and inactivating MAPKs ( including p38 , ERK , and JNK ) , IkappaB - alpha , and NF - kappaB ( p65 ) in dorsal skin . - pubmed
CONCLUSIONS : HLJDT significantly improved AD - like symptoms via inhibition of the MAPKs / NF - kappaB pathway . - pubmed
PURPOSE : To investigate the differences in protein expression between Dpy19l2 - deficient human globozoospermia and normozoospermia . - pubmed
EXPERIMENTAL DESIGN : Human sperm samples from three globozoospermic donors with Dpy19l2 deletion and three normal controls are subjected to TMT quantitative technology . - pubmed
The levels of several important proteins , including SPACA 1 , IZUMO1 , ZPBP1 , and PLCZ1 , are decreased in globozoospermic sperm . - pubmed
CONCLUSIONS AND CLINICAL RELEVANCE : The present study is the first to analyze total globozoospermia with Dpy19l2 deletion using high - throughput proteomics . - pubmed
RESULTS : In the training cohort , hepatocellular carcinoma ( HCC ) , diabetes , total bilirubin ( TBIL ) , albumin ( ALB ) , alanine aminotransferase ( ALT ) , and serum creatinine ( Scr ) were independent predictors of in - hospital death . - pubmed
SG - SP1 Suppresses Mast Cell - Mediated Allergic Inflammation via Inhibition of FcepsilonRI Signaling . - pubmed
To improve on preliminary evidence that GA has allergy mitigating effect , we designed SG - SP1 based on GA , and aimed to assess the effects of SG - SP1 on mast cell - mediated allergic inflammation using various animal and in vitro models . - pubmed
Immunoglobulin ( Ig ) E - induced passive cutaneous anaphylaxis and ovalbumin - induced systemic anaphylaxis , standard animal models for immediate - type hypersensitivity were also used . - pubmed
Oral administration of SG - SP1 hindered allergic symptoms of both anaphylaxis models evidenced by reduction of hypothermia , serum IgE , ear thickness , and tissue pigmentation . - pubmed
Conclusions : We determined that SG - SP1 directly interacts with FcepsilonRI and propose SG - SP1 as a therapeutic candidate for mast cell - mediated allergic inflammatory disorders via inhibition of FcepsilonRI signaling . - pubmed
In all patients with thyrotoxicosis , multiple linear regression analyses showed free thyroxine ( FT(4 ) ) ( beta=0.371 , 95%CI 0.005 - 0.010 , P<0.001 ) and TRAb ( beta=0.138 , 95%CI 0.001 - 0.014 , P=0.035 ) were positively associated with STA - PSV . - pubmed
Conclusions : The STA - PSV is positively associated with FT(4 ) and TRAb levels , and it is a helpful marker in differential diagnosis between GD and AIT . - pubmed
Metastasis of Uveal Melanoma with Monosomy-3 Is Associated with a Less Glycogenetic Gene Expression Profile and the Dysregulation of Glycogen Storage . - pubmed
UMs with monosomy-3 exhibited a less glycogenetic and more insulin - resistant gene expression profile , together with the reduction of glycogen levels , which were associated with the metastases . - pubmed
Expression of glycogenin-1 ( Locus : 3q24 ) was lower in the monosomy-3 tumors , whereas the complementary isoform glycogenin-2 ( Locus : Xp22.33 ) was upregulated in females . - pubmed
MicroRNA-130a-3p promotes the proliferation and inhibits the apoptosis of cervical cancer cells via negative regulation of RUNX3 . - pubmed
In conclusion , miR-130a-3p promoted proliferation , migration and invasion , and inhibited the apoptosis of CC cells via targeting RUNX3 , suggesting a novel treatment target for CC . - pubmed
RESULTS : Independently of their localization in different anatomic niches , macrophages in mice with transplanted Ehrlich carcinoma gradually lose their tumoricidal activities while arginase activity is upregulated . - pubmed
Stress - induced premature senescence activated by the SENEX gene mediates apoptosis resistance of diffuse large B - cell lymphoma via promoting immunosuppressive cells and cytokines . - pubmed
RESULTS : The proportion of senescent lymphoma cells was significantly increased in r / r DLBCL patients , concomitant with increased Treg , MDSC , and various secreted cytokines with proinflammatory and immunosuppressive effects . - pubmed
The SENEX gene was significantly elevated in the SIPS model . - pubmed
Senescent DLBCL cells had good antiapoptotic ability and proliferative activity accompanied by increased immunosuppressive cytokines . - pubmed
CONCLUSION : SIPS activated by the SENEX gene mediates apoptosis resistance of r / r DLBCL via promoting immunosuppressive cells and cytokines . - pubmed
Cryptorchidism and gonadotrophin therapy . - pubmed
[ Assessment of the B - cell function in diabetic patients by means of the determination of insulin secretion following glucose - tolbutamide stimulation ] . - pubmed
In this study , the thyroxine ( T4 ) and triiodothyronine ( T3 ) serum concentrations , and thyrotropin ( TSH ) response to intravenous administration of thyrotropin releasing hormone ( TRH ) were determined in 6 patients ( aged 9 to 15 yr ) with anorexia nervosa and the results compared to those found in a group of 15 normal subjects . - pubmed
Doses of rMuIFN - gamma that had no effect on papilloma multiplicities when administered 1 day prior to TPA treatment increased the numbers of papillomas per mouse by 33 - 38 % when administered immediately prior ( zero time ) to TPA application . - pubmed
Carcinoma incidence and multiplicities by weeks 46 - 48 of the promotion - progression period were statistically indistinguishable for initiated mice treated with TPA , TPA + DFMO , TPA + IFN - gamma or TPA + DFMO + IFN - gamma . - pubmed
administration of rMuIFN - gamma to papilloma - bearing mice in a tumor progression study , with and without simultaneous topical TPA treatment , did not affect carcinoma latency or carcinoma multiplicities . - pubmed
administration of rMuIFN - gamma to C57BL/6 mice at the time of TPA treatment , at doses that were co - promoting in SENCAR mice , did not increase papilloma multiplicities . - pubmed
UNLABELLED : The aim of the study was to investigate the prevalence of antinuclear and associated antibodies ( anti - dsDNA , anticardiolipin , anti - RNP , anti - Sm , anti - SSA and anti - SSB ) and/or combinations thereof in systemic lupus erythematosus ( SLE ) patients with respect to their diagnostic and pathogenetic significance . - pubmed
The prevalence of anti - dsDNA antibodies was strongly influenced by the selection criteria of the patient ; the lowest prevalence was found in SLE patients with central nervous system ( CNS ) involvement ; the highest prevalence in patients with nephritis . - pubmed
No difference in anticardiolipin antibody prevalence between the different SLE patient groups could be demonstrated . - pubmed
Regarding antibodies against RNP , Sm , SSA and SSB , the prevalence was found to be strongly influenced by the criteria used for patient selection . - pubmed
The effects of plasma lipids , blood glucose , and serum total cholesterol , LDL - cholesterol , VLDL - cholesterol , 6 - month period were studied in 18 patients with essential hypertension . - pubmed
The elevated release of monokines , especially interleukin I from monocytes of rheumatoid arthritis patients triggered by rheumatoid factors , immunocomplexes , complement compounds and other serum factors , may explain the phenomenon . - pubmed
Effect of obesity on ambient plasma glucose , free fatty acid , insulin , growth hormone , and glucagon concentrations . - pubmed
Fasting and postprandial plasma concentrations of glucose , FFA , insulin , glucagon , and GH concentrations were determined in 10 nonobese and 10 obese subjects with normal glucose tolerance . - pubmed
Although plasma glucose concentrations were similar throughout the 8 - h period in the 2 groups , plasma insulin concentrations were significantly ( P less than 0.001 ) higher in the obese individuals . - pubmed
Immunogenicity of " single peak " beef - pork insulin in diabetic subjects . - pubmed
[ Prostaglandins and the kallikrein - kinin systems in the normal pregnancy - puerperium cycle and in hypertensive disease proper to pregnancy ] . - pubmed
Five multiple forms of chemically cleaved inhibitors ( UTIB - I , UTIB - II , UTIB - III , UTIB - IV and UTIB - V ) could be isolated from BrCN - treated L - UTI by isoelectric focusing and gel filtration . - pubmed
The production of IgE antibody against Candida albicans in atopic patients with bronchial asthma ] . - pubmed
[ New biochemical aspects of diabetes : receptor problems and insulin mutations ] . - pubmed
Erythromycin has been shown to act on motilin receptors on gastrointestinal smooth muscle in vitro and to accelerate gastric emptying in normal subjects as well as in patients with diabetic mellitus . - pubmed
The T47D ( A1 - 2 ) cell line is a human mammary carcinoma - derived cell line that has been engineered to constitutively express comparable levels of both glucocorticoid and progesterone receptors . - pubmed
A subset of patients ( 50 % ) with neuroborreliosis ( Lyme disease ) showed IgG reactivity to cardiolipin in solid phase ELISA . - pubmed
In addition , a subset of patients with neuroborreliosis ( 29 % ) and syphilis ( 59 % ) had IgM reactivity to gangliosides with a Gal ( beta 1 - 3 ) GalNac terminal sequence ( GM1 , GD1b , and asialo GM1 ) . - pubmed
Anti - ganglioside IgM antibodies were significantly more frequent in these two groups of patients compared to patients with cutaneous and articular Lyme disease , primary antiphospholipid syndrome , systemic lupus erythematosus and normal controls . - pubmed
Given the clinical associations of patients with neuroborreliosis and syphilis with IgM reactivity to gangliosides sharing the Gal ( beta 1 - 3 ) GalNac terminus , we suggest that these antibodies could represent a response to injury in neurological disease or a cross reactive event caused by spirochetes . - pubmed
This study investigates the reliability of glycated haemoglobin , measured by electroendosmosis or by affinity chromatography , fructosamine , and albumin adjusted fructosamine , as indices of glycaemic control in Type 1 diabetes complicated by chronic renal failure . - pubmed
The regression equations did not differ significantly between subjects with renal failure and those with normal renal function , suggesting that similar ranges can be used in interpreting glycated haemoglobin results from each group of patients . - pubmed
Two hundred and twenty - eight HIV positive individuals underwent motor and sensory nerve conduction studies , CSF evaluation , peripheral CD4 - T lymphocyte count , and neurologic evaluation to determine the presence or absence of peripheral neuropathy . - pubmed
We also compared CSF parameters in a subset of CD4 - matched patients with and without neuropathy . - pubmed
Allelic variability in D21S11 , but not in APP or APOE , is associated with cognitive decline in Down syndrome . - pubmed
Genetic variation in the APOE gene and variation in chromosome 21 genotypes , including the APP locus , may influence age - associated cognitive decline in adults with Down syndrome . - pubmed
Genetic variability at APOE and APP was not significantly associated with evidence of cognitive decline . - pubmed
Responses of lean and obese Zucker rats to centrally administered leptin . - pubmed
Obese ( Lepr(fa)/Lepr(fa ) ) Zucker rats have a missense mutation in the leptin receptor gene . - pubmed
However , conflicting reports exist on whether obese Zucker rats can respond to centrally administered leptin . - pubmed
administered leptin and to compare the responses of lean and obese Zucker rats . - pubmed
Both single and daily leptin administration also decreased respiratory quotient ( RQ ) similarly in lean and obese Zucker rats , indicating mobilization of fat as an energy source for leptin - treated rats . - pubmed
After withdrawal of daily leptin treatment , lean and obese Zucker rats exhibited different recovery responses . - pubmed
It is concluded that obese Zucker rats can respond to exogenous leptin when leptin is delivered into the brain ventricles . - pubmed
We found that the MTHFR T / T genotype was strongly correlated with intermediate hyperhomocysteinemia , being present in 73.9 % of those cases ( 17 of 23 ) . - pubmed
This indicates that a search for CBS mutations in patients with severe hyperhomocysteinemia is important to ensure the detection of a possible CBS deficiency , thus enabling treatment . - pubmed
Co - existence of the MTHFR T / T genotype and the common CBS 844ins68 variant was significantly higher among patients ( 10.7 % ) as compared to controls ( 1.2 % ) , indicating that this genotype combination is a thrombotic risk factor ( P & lt;0.05 ) . - pubmed
Despite the high virus titers , rCVB3 infection of naive mice failed to induce a strong CD8 + T - cell response to the encoded epitope ; this has implications for the proposed role of " cross - priming " during virus infection and for the utility of recombinant picornaviruses as vaccine vectors . - pubmed
These anti - invasive effects appear to be mediated through the downregulation of MMP-2 ( matrix metalloproteinase ) and the upregulation of TIMP-1 ( tissue inhibitor of metalloproteinase ) , 2 common effector molecules that have been implicated in regulating tumor cell invasion . - pubmed
Polyclonal antibodies have been generated to the cloned urea transporter proteins , and the use of these antibodies in integrative animal studies has resulted in several novel findings , including : ( 1 ) the surprising finding that UT - A1 protein abundance and urea transport are increased in the inner medulla during conditions in which urine concentrating ability is reduced ; ( 2 ) vasopressin increases UT - A1 phosphorylation in rat inner medullary collecting duct ; ( 3 ) UT - A protein abundance is upregulated in uremia in both liver and heart ; and ( 4 ) UT - B is expressed in many nonrenal tissues and endothelial cells . - pubmed
This review will summarize the knowledge gained from using molecular approaches to perform integrative studies into urea transporter protein regulation , both in normal animals and in animal models of human diseases , including studies of uremic rats in which urea transporter protein is upregulated in liver and heart . - pubmed
Although flurbiprofen abolished endotoxin - induced fever , which is a centrally generated , prostaglandin - mediated response , it failed to reverse blockade of the LH surge . - pubmed
Four polymorphisms were evaluated , including the serotonin transporter HTTLPR promoter ins / del , GABAAalpha6 Pro385Ser , NPY Leu7Pro , and catalase 262C>T. Two of these , HTTLPR and GABAAalpha6 Pro385Ser , had been previously associated with LR and alcoholism in a preliminary study . - pubmed
CONCLUSIONS : This report strengthens the support for a relationship between the HTTLPR L and GABAAalpha6 Ser385 alleles to low alcohol LR and to alcoholism in a prospectively studied cohort evaluated for LR in young adulthood and before the onset of alcohol dependence . - pubmed
Several lines of evidence suggest that D - serine , an endogenous agonist of the glycine site on the NMDA receptors , might play a role in the pathophysiology of schizophrenia . - pubmed
This study suggests that synthetic or metabolic pathways of D - serine may be abnormal in the brain of drug - naive schizophrenic patients , supporting the NMDA receptor dysfunction hypothesis of schizophrenia . - pubmed
Several differences were noted between the amount of collagen present according to hydroxyproline measurement and the stages of fibrosis according to histology . - pubmed
CONCLUSIONS : Although increases in collagen content ( by hydroxyproline ) approximately paralleled increases in fibrosis stage ( by histology ) , there was considerable overlap and some discrepancies . - pubmed
Kinetics of prebeta1 HDL and alphaHDL in type II diabetic patients . - pubmed
BACKGROUND : The aim of this study was to analyze the recycling of high density lipoprotein ( HDL ) in six type II diabetic patients compared with six control subjects by endogenous labelling of apolipoprotein A - I ( Apo A - I ) with stable isotope Apo A. - pubmed
RESULTS : Plasma Apo A - I concentration was decreased in patients with type II diabetes as a result of a decrease in Apo A - I - alphaHDL ( P & lt ; 0.05 ) . - pubmed
Diabetic patients were also characterized by an increased relative contribution of Apo A - I in prebeta1 HDL ( 18.3 + /- 2.8 % vs 11.9 + /- 3.7 % , P & lt ; 0.01 ) . - pubmed
The synthetic rate of prebeta1 HDL was slightly increased in diabetic patients compared with control ( NS ) and an increase of recycling rate of alpha to prebeta1 HDL was observed ( 11.67 + /- 3.14 d(-1 ) vs 7.09 + /- 4.51 d(-1 ) , P & lt ; 0.05 ) . - pubmed
The clearance rate of Apo A - I was higher in diabetic patients ( P & lt ; 0.05 for Apo A - I - prebeta1 HDL and P & lt ; 0.005 for Apo A - I - alphaHDL ) . - pubmed
CONCLUSION : This study suggests that the usual increase in prebeta1 HDL in type II diabetic patients is mainly related to an increased conversion rate of alpha to prebeta1 HDL . - pubmed
The use of B - type natriuretic peptide in the management of patients with diabetes and acute dyspnoea . - pubmed
AIMS / HYPOTHESIS : The aim of this study was to determine the impact of measurement of B - type natriuretic peptide ( BNP ) levels on the management of patients with diabetes presenting with acute dyspnoea . - pubmed
METHODS : This study evaluated the subgroup of 103 patients with diabetes included in the B - type Natriuretic Peptide for Acute Shortness of Breath Evaluation ( BASEL ) study ( n=452 ) . - pubmed
CONCLUSIONS / INTERPRETATION : The results of this study indicate that measurement of BNP levels improves the management of patients with diabetes presenting with acute dyspnoea . - pubmed
This article focuses on the mechanisms by which hormone resistance develops , including the reactivation of androgen receptor during androgen deprivation therapy , the role of cancer stem cells , and the emergence of epithelial - mesenchymal transition cells , which have increased metastatic potential . - pubmed
[ Hydrogen sulphide water balneum effect on erythrocyte catalase activity in patients with rheumatoid arthritis -- in vitro study ] . - pubmed
The aim of the study was to investigate , in vitro , hydrogen sulphide water ( HSW ) balneum effect on erythrocyte catalase activity in patients with rheumatoid arthritis . - pubmed
The mean baseline erythrocyte catalase activity ( to ) was in rheumatoid arthritis patients of about 7.79 + /- 1.39 U / gHb and was significantly higher than in the control group : 6.96 + /- 2.68 U / gHb ( p & lt ; 0.05 ) . - pubmed
After 5 minutes incubation with HSW ( t5 ) erythrocyte catalase activity increased , in rheumatoid arthritis patients to 8.21 + /- 1.77 U / gHb , after 10 minutes ( t10 ) was 8.14 + /- 2.25 U / gHb , in control group : 7.58 + /- 2.50 U / gHb and 7.68 + /- 3.22 U / gHb , respectively . - pubmed
After 20 minutes of incubation ( t20 ) erythrocyte catalase activity was the highest in the patients with active rheumatoid arthritis ( 8.33 + /- 1.96 U / gHb ) and differed significantly from the patients in remission ( 6.69 + /- 1.27 U / gHb ) and from patients not receiving non - steroidal anti - inflammatory drugs ( 6.04 + /- 1.08 U / gHb ) . - pubmed
In rheumatoid arthritis patients erythrocyte catalase activity was higher when compared with control group and increased during incubation with HSW . - pubmed
Insulin sensitivity ( assessed by homeostasis model assessment 2 modeling ) , androgen , and HDL cholesterol levels were significantly decreased , whereas total fat mass and LDL cholesterol , triglyceride , CRP , leptin , and fructosamine levels were significantly increased in untreated Klinefelter ' s syndrome patients . - pubmed
In treated Klinefelter ' s syndrome patients , LDL cholesterol and adiponectin were significantly decreased , whereas no difference in body composition was found in comparison with untreated Klinefelter ' s syndrome patients . - pubmed
Peroxisome proliferator - activated receptor gamma and growth inhibition by its ligands in uterine endometrial carcinoma . - pubmed
PURPOSE : In this study , we evaluated the correlation between endometrial carcinoma and peroxisome proliferator - activated receptor gamma ( PPARgamma ) expression and assessed whether PPARgamma ligands influence carcinoma growth . - pubmed
EXPERIMENTAL DESIGN : We examined the presence and cellular distribution of PPARgamma protein in 42 normal endometria , 32 endometria with hyperplasia , and 103 endometria with endometrial carcinoma by immunohistochemistry . - pubmed
We then compared PPARgamma mRNA expression in endometrial carcinoma with that in normal endometria using real - time reverse transcription - PCR . - pubmed
We subsequently confirmed expression of PPARgamma mRNA by real - time reverse transcription - PCR and PPARgamma protein by immunoblotting in endometrial carcinoma cell lines ( Ishikawa , Sawano , and RL95 - 2 cells ) . - pubmed
We further examined the effects of PPARgamma agonist 15 - deoxy - Delta12,14 - prostaglandin J2 ( 15d - PGJ2 ) , a naturally occurring PPARgamma ligand , to these endometrial carcinoma cell lines . - pubmed
We also examined the status of apoptosis and p21 mRNA expression of these endometrial carcinoma cell lines following addition of 15d - PGJ2 . - pubmed
RESULTS : PPARgamma immunoreactivity was detected in 11 of 23 ( 48 % ) of proliferative - phase endometrium , 14 of 19 ( 74 % ) of secretory - phase endometrium , 27 of 32 ( 84 % ) of endometrial hyperplasia , and 67 of 103 ( 65 % ) of carcinoma cases . - pubmed
PPARgamma immunoreactivity was significantly lower in endometrial carcinoma than in secretory - phase endometrium ( P = 0.012 ) and endometrial hyperplasia ( P = 0.006 ) . - pubmed
There was a significant positive association between the status of PPARgamma and p21 expression in endometrial carcinoma ( P & lt ; 0.0001 ) . - pubmed
There was a significant negative association between the body mass index and PPARgamma labeling index of carcinoma tissue in the patients with endometrial carcinoma ( P & lt ; 0.0001 ) . - pubmed
PPARgamma mRNA was expressed abundantly in normal endometria but not in endometrial carcinoma . - pubmed
We showed that PPARgamma agonist 15d - PGJ2 inhibited cell proliferation and induced p21 mRNA of endometrial carcinoma cell lines . - pubmed
CONCLUSION : We showed the expression of PPARgamma in human endometrial carcinoma and the effects of PPARgamma ligand in endometrial carcinoma cells . - pubmed
These findings suggest that a PPARgamma ligand , 15d - PGJ2 , has antiproliferative activity against endometrial carcinoma . - pubmed
Suppression of carrageenan- and collagen II - induced inflammation in mice by geranium oil . - pubmed
To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases , we examined the effects of geranium oil on carrageenan - induced and collagen II - induced inflammation in mice , to assess acute and chronic anti - inflammatory activities of the oil . - pubmed
Single intraperitoneal injection of 5 mu L of geranium oil clearly suppressed the carrageenan - induced footpaw edema and increase in tissue myeloperoxidase activity , and repeated administration of the oil suppressed collagen - induced arthritis . - pubmed
We have previously validated transgenic mice overexpressing the neurotrophin-3 ( NT-3 ) receptor , TrkC ( TgNTRK3 ) , as an engineered murine model of panic disorder . - pubmed
We could determine that TgNTRK3 mice presented increased cellularity in brain regions , such as the locus ceruleus , that are important neural substrates for the expression of anxiety in severe anxiety states . - pubmed
Here , we investigated the sensitivity to induce anxiety and panic - related symptoms by sodium lactate and the effects of various drugs ( the alpha2 - adrenoceptor antagonist , yohimbine and the adenosine antagonist , caffeine ) , in TgNTRK3 mice . - pubmed
Our findings validate the relevance of the NT-3 / TrkC system to pathological anxiety and raise the possibility that a specific set of fear - related pathways involved in the processing of anxiety - related information may be differentially activated in panic disorder . - pubmed
All muscles injected with botulinum toxin showed decreased wet weight and persistent weakness upon completion of the study . - pubmed
Injection of botulinum toxin in the gastrocnemius may minimize equinus contracture and protect the anterior tibialis from damage during human tibial lengthening . - pubmed
Reverse transcriptase polymerase chain reaction was used to further examine the expression pattern of these genes during soybean infection . - pubmed
PURPOSE : Ovarian suppression with luteinizing hormone - releasing hormone ( LHRH ) agonists is an effective adjuvant treatment for premenopausal women with estrogen receptor ( ER ) - positive breast cancer . - pubmed
PATIENTS AND METHODS : This randomized phase III trial was performed to compare the 3 - monthly depot LHRH agonist leuprorelin acetate ( LAD-3 M ; n = 299 ) and chemotherapy with cyclophosphamide , methotrexate , and fluorouracil ( CMF ; n = 300 ) in pre- or perimenopausal patients with ER - positive , node - positive breast cancer . - pubmed
CONCLUSION : The 3 - monthly depot LHRH - agonist leuprorelin acetate is an effective adjuvant treatment in premenopausal patients with hormone receptor - positive , node - positive breast cancer that is not inferior to CMF . - pubmed
DATA SOURCES : Comprehensive search using keywords AVP receptor antagonists , hyponatremia , SIADH , conivaptan , tolvaptan , lixivaptan , nurse practitioner , and others was carried out using the National Library of Medicine ( PubMed ) Web site from which full - text articles were obtained . - pubmed
In clinical trials , a new class of drugs called the arginine vasopressin ( AVP ) receptor antagonists or aquaretics has been shown to be safe and effective for the treatment of hyponatremia . - pubmed
The association of interferon with the development of pulmonary tuberculosis . - pubmed
We report a new case of a patient suffering from chronic hepatitis C ( CHC ) and treated with interferon - alpha2a ( IFN - alpha ) who presented with the diagnosis of active pulmonary tuberculosis . - pubmed
Our case demonstrates a rare association between interferon and tuberculosis since only one case in the literature has described a similar association . - pubmed
These latter genes are involved in tau protein phosphorylation , and their increased expression in hydrocephalus was confirmed by real - time polymerase chain reaction analysis . - pubmed
CONCLUSIONS : The accumulation of phosphorylated tau protein in the cerebral cortex may be one of the mechanisms by which later cognitive dysfunction develops in patients with compensated hydrocephalus . - pubmed
More work needs to be done to determine if the accumulation of phosphorylated tau in the cortex can help predict which patients may decompensate thus requiring more aggressive treatment for compensated hydrocephalus . - pubmed
RESULTS : The findings demonstrate that when receiving the reflexology treatment condition , as compared to the control condition , the residents demonstrated significant reduction in observed pain and salivary alpha - amylase . - pubmed
The most frequent subtype of autosomal dominant inherited spinocerebellar ataxias is caused by CAG repeat expansions of more than 55 units in the ataxin-3 gene . - pubmed
We have included the Gunn rat as a model of an inherited liver disease without hepatocyte damage and Abcb4 knockout mice as a model for an inherited liver disease with hepatocyte damage . - pubmed
We describe problems that can be encountered in the maintenance and breeding of Gunn rats and immunodeficient Rag2 / gamma common knockout mice . - pubmed
In the present study , we examined the relevance of the apoptosis repressor with caspase recruitment domain ( ARC ) on cardiac myocyte survival and its underlying mechanisms in a model of Dox - induced cardiotoxicity . - pubmed
In this study , we provide evidence for the protective role of anti - apoptotic ARC in Dox - induced cardiotoxicity , which makes this molecule an interesting target for future therapies . - pubmed
Chimeric antigen T cell receptors provide a good approach for adoptive immunotherapy of cancer , especially in the context of cancerous cells that fail to express major histocompatibility complex antigen and co - stimulatory molecules . - pubmed
MUC1 is a highly attractive immunotherapeutic target owing to increased expression , altered glycosylation , and loss of polarity in more than 80 % of human malignancies . - pubmed
If sufficient conditions arise , genetic factors that influence the expression of CRB1 mutations in Coats - like retinitis pigmentosa should be detected . - pubmed
Histone deacetylases ( HDACs ) are enzymes involved in tumor genesis and development . - pubmed
Functional analysis of two single nucleotide polymorphisms in SLC30A2 ( ZnT2 ): implications for mammary gland function and breast disease in women . - pubmed
Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas . - pubmed
Recent work has identified novel point mutations in isocitrate dehydrogenase 1 ( IDH1 ) in the majority of the World Health Organization grades II and III infiltrative gliomas and secondary grade IV glioblastomas . - pubmed
In this multi - institutional study , 98 cases originally diagnosed as ganglioglioma were analyzed for IDH1 mutations , 86 of which had follow - up data available . - pubmed
The presence of mutant IDH1 in gangliogliomas correlated with a greater risk of recurrence ( P=0.0007 ) and malignant transformation and/or death ( P<0.0001 ) compared with tumors that were IDH1 wild type . - pubmed
Furthermore , the age of patients with IDH1 - mutant gangliogliomas was higher than those without mutations ( 25.5 vs. 46.1 years , P=0.0033 ) . - pubmed
IDH1 / 2 testing of tumors suspected of being gangliogliomas may therefore be advisable , particularly in the adult population . - pubmed
Mutations in eomesa / tbr2 cause microcephaly in humans , whereas lhx2b is a critical regulator of cell fate and axonal targeting in the developing forebrain . - pubmed
These results demonstrate the feasibility of employing genomic SELEX to identify vertebrate transcription factor binding sites and target genes and reveal Fezf2 as a transcription activator and a candidate for evaluation in human microcephaly . - pubmed
Several examined hyperkalemia associated with angiotensin - converting enzyme ( ACE )- inhibitor / angiotensin II receptor blocker ( ARB ) , diuretic ( potassium - sparing ) , and beta - blocker use . - pubmed
Finally , orthostatic hypotension was evaluated in those taking ACE - inhibitor / ARB , beta - blocker , or calcium - channel blocker therapy . - pubmed
The role of p27 ( Kip1 ) in dasatinib - enhanced paclitaxel cytotoxicity in human ovarian cancer cells . - pubmed
METHODS : A library of silencing RNAs ( siRNAs ) was used to identify kinases that regulate paclitaxel sensitivity in human ovarian cancer SKOv3 cells . - pubmed
The effect of dasatinib , an inhibitor of Src and Abl kinases , on paclitaxel sensitivity was measured in ovarian cancer cells and HEY xenografts . - pubmed
The siRNA knockdown of Src , Fyn , or Abl1 enhanced paclitaxel - mediated growth inhibition in ovarian cancer cells compared with a control siRNA . - pubmed
CONCLUSION : Inhibition of Src family and Abl kinases with either siRNAs or dasatinib enhances paclitaxel sensitivity of ovarian cancer cells through p27(Kip1)-mediated suppression of Bcl-2 and Cdk1 expression . - pubmed
Many primary human tumors and tumor cell lines highly express human L - type amino acid transporter 1 ( hLAT1 ) ; cancerous cells in vivo are strongly linked to LAT1 expression . - pubmed
Combined genetic inactivation of beta2 - Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma . - pubmed
We report that diffuse large B cell lymphoma ( DLBCL ) commonly fails to express cell - surface molecules necessary for the recognition of tumor cells by immune - effector cells . - pubmed
In addition to gene inactivation , alternative mechanisms lead to aberrant expression of HLA - I and CD58 in & gt;60 % of DLBCL . - pubmed
A novel single - base deletion mutation of the RUNX2 gene in a Chinese family with cleidocranial dysplasia . - pubmed
We identified a disease - causing mutation of the RUNX2 gene in a four - generation Chinese family affected with cleidocranial dysplasia ( CCD ) . - pubmed
We demonstrated that a novel mutation ( c.549delC ) of RUNX2 is associated with CCD in a Chinese family , adding to the repertoire of RUNX2 mutations related to CCD . - pubmed
Finally , Staufen affects HIV and influenza infection at several levels . - pubmed
To date , peptide receptor radionuclide therapy seems to be an acceptable option and is relatively safe in adult advanced NET patients with receptor uptake positive on scintigraphy , but patients ' renal function must be monitored . - pubmed
Role of nuclear factor ( erythroid - derived 2 )- like 2 in metabolic homeostasis and insulin action : A novel opportunity for diabetes treatment ? - pubmed
While oxidative stress is among the early events that lead to the development of insulin resistance , the activation of Nrf2 scavenging capacity leads to insulin sensitization . - pubmed
Here we summarize recent findings that link the Nrf2 system to metabolic homeostasis and insulin action and present our view that Nrf2 may serve as a novel drug target for diabetes and its complications . - pubmed
Seven hundred and one AD patients with at least 3 different cognitive evaluations and genotypic information for APOE and 6 genome wide association study - significant single - nucleotide polymorphisms were selected for this study . - pubmed
The PICALM single - nucleotide polymorphism also displayed a significant effect protecting against rapid progression during pharmacogenetic assays although its observed effect displayed heterogeneity among AD therapeutic protocols ( p = 0.039 ) . - pubmed
Childhood immune thrombocytopenia : role of rituximab , recombinant thrombopoietin , and other new therapeutics . - pubmed
However , because immunosuppressive agents such as rituximab are not approved for use in ITP and the thrombopoietin receptor agonists are not yet approved in children , the decision to use alternatives to splenectomy needs to be considered carefully . - pubmed
Owing to the pleiotropic characteristics of the target , anti - TNF - alpha blockers may affect several mechanisms beyond rheumatoid synovitis . - pubmed
As TNF - alpha plays a pivotal role in the induction of early atherosclerosis , treatment with TNF - inhibitors may modulate cholesterol handling , in particular , cholesterol efflux from macrophages . - pubmed
The efficacy of an anti - C5 monoclonal antibody fused to a peptide targeting inflamed synovia in experimental arthritis opened the way for new strategies : Homing to the synovium of molecules neutralizing TNF would allow to maximize the therapeutic action avoiding the side effects . - pubmed
Two of these genes ( FAM129A , SYNPO2 ) were associated with airway hyperresponsiveness ( provocative concentration of methacholine causing a 20 % drop in FEV1 : r = -0.740 , P & lt ; 0.01 ; r = -0.746 , P & lt ; 0.01 ) . - pubmed
The derived function of VDAC , therefore , might underlie the development of autism . - pubmed
The aim of this study was to compare the U - II levels in knee synovial fluids obtained from osteoarthritic and non - osteoarthritic patients . - pubmed
Levels of U - II were measured by using ELISA kit U - II levels were significantly higher in the osteoarthritic group than that in the control group . - pubmed
In conclusion , the significantly high U - II levels in the knee synovial fluid of osteoarthritic patients supported our hypothesis that " U - II may be associated with the synovial fibrosis in osteoarthritis " . - pubmed
Anti - vascular endothelial growth factors ( VEGF ) agents have revolutionized the treatment of retinal diseases . - pubmed
AIM : To assess differing patterns and levels of ascitic fluid cyctokine and growth factors exist between those with a high risk and low risk of spontaneous bacterial peritonitis ( SBP ) . - pubmed
Individuals with alcoholic cirrhosis had the highest levels of IL-1A , IL-1B , IL-4 , IFNgamma . - pubmed
Those with hepatitis C virus ( HCV ) associated cirrhosis had the highest value for IL-6 , IL-8 , IL-10 , MCP-1 and VEGF . - pubmed
Those with cardiac disease had the highest level of TNF - alpha and EGF . - pubmed
The calculated serum- ascites gradients for the cardiac and malignant disease groups had a greater frequency of negative values signifying greater levels of IL-8 , IL-10 and MCP-1 in ascites than did those with alcohol or HCV disease . - pubmed
CONCLUSION : These data document important differences in the cytokine and growth factor levels in plasma , ascitic fluid and the calculated plasma - ascites fluid gradients in cirrhotics requiring a large volume paracentesis . - pubmed
[ The role of allogeneic hematopoietic stem cell transplant in therapy of chronic myeloid leukemia in the era of tyrosine kinase inhibitors ] . - pubmed
BACKGROUND : Asymmetric dimethylarginine ( ADMA ) , the main endogenous inhibitor of nitric oxide synthase , is considered to be associated with endothelial dysfunction . - pubmed
METHODS : This was a single arm , prospective , observational multicenter and phase IV clinical trial for 279 patients , who were newly diagnosed as CD20 - positive DLBCL from 24 medical centers in China 2011 and 2012 , no special exclusion criteria were used . - pubmed
Elevated levels of sFlt1 were associated with a 2.8 - fold increased risk of hypothyroxinemia ( P = .04 ) . - pubmed
Decreased levels of PlGF were associated with a 6.7 - fold increased risk of hypothyroxinemia ( P & lt ; .001 ) . - pubmed
Within the normal range , a dose - dependent effect of sFlt1 on thyroid dysfunction was observed : high - normal sFlt1 levels were associated with a 17.7 - fold increased risk of hypothyroxinemia ( P & lt ; .001 ) and a 2.7 - fold increased risk of hyperthyrotropinemia ( P = .01 ) . - pubmed
Abnormal as well as normal - range fetal sFlt1 and PlGF levels influence the risk of impaired newborn thyroid function , which has been associated with adverse neurodevelopmental effects . - pubmed
This study is the first report which demonstrates the cartilage protective effect of 5,7,3 ' , 4 '- tetramethoxyflavone ( TMF ) by decreasing the concentration of IL-1beta , TNF - alpha and PGE2 in the knee synovial fluid in OA rat models in vivo . - pubmed
Serum levels of miR-197 and miR-10b were inversely correlated with degree of inflammation and miR-181d and miR-99a were inversely correlated with serum gamma glutamyl transferase levels in non - alcoholic steatohepatitis patients . - pubmed
However , modeling and experimental studies on the intravenous anesthetic propofol indicate that potentiation of gamma - aminobutyric acid receptors leads to a state of thalamocortical synchrony , observed as coherent frontal alpha oscillations , associated with unconsciousness . - pubmed
RESULTS : On transplantation , the peripheral CD19CD24CD38 transitional B cell subset strongly declined , regardless of the subsequent occurrence of AR . - pubmed
In contrast , TCL1A expression levels increased in stable patients , but decreased in patients at the time of AR in both PBMC and isolated B cells . - pubmed
At the time of AR , CD79B gene expression was significantly lower compared to stable patients , being most apparent in the B - cell fraction . - pubmed
Differences in expression of proliferation - associated genes and RANKL across the menstrual cycle in estrogen receptor - positive primary breast cancer . - pubmed
The purpose of this study is to determine if there are differences in the expression of estrogen - regulated genes ( ERGs ) , proliferation - associated genes and the progesterone effector RANKL , in premenopausal ER + breast cancer as a result of the major changes in hormone levels that occur through the menstrual cycle . - pubmed
Primary ER+ tumours from 174 patients were assigned to one of three menstrual cycle windows : W1 ( days 27 - 35 + 1 - 6 ) , W2 ( days 7 - 16 ) and W3 ( days 17 - 26 ) . - pubmed
Expression of proliferation - associated genes and RANKL in ER+ breast tumours varies across the menstrual cycle showing a different rhythm to that of ERGs . - pubmed
Following investigation to exclude the usual causes of toxicity , it was surmised that impaired CYP1A2 function , secondary to the acute inflammatory process , had led to a toxic level of the drug . - pubmed
The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia . - pubmed
This study aimed to identify the expression of semaphorin 3C ( SEMA3C ) in the normal - metastatic spectrum of breast and oral cancers , and correlate expression with microvessel density ( MVD , CD31 ) , a surrogate marker of angiogenesis . - pubmed
Histological analysis revealed that SEMA3C expression was reduced in the development of oral cancer from normal oral tissue ( P<0.0001 ) and expression was inversely correlated with MVD ( r=-0.394 , P=0.05 ) . - pubmed
In contrast , SEMA3C expression increased in the transition from normal to invasive breast disease in epithelial / tumour cells ( P=0.001 ) and endothelial cells ( P=0.006 ) , with both correlating weakly with MVD ( r=0.35 , p=0.03 and r=0.243 , p=0.041 respectively ) . - pubmed
Furthermore , histological analysis of a breast cancer tissue microarray revealed a weak positive correlation with tumour grade ( r=0.305 , P=<0.001 ) and biological phenotype ( r=0.237 , p=0.004 ) with tumour cell expression of SEMA3C highest in triple negative and ER- , PR- , HER2 + subtypes . - pubmed
These data suggest that SEMA3C expression is differentially regulated in the development and progression of breast versus oral neoplasia , and that increased expression of SEMA3C may be modulating breast cancer progression and angiogenesis , and could represent a biomarker of metastatic disease . - pubmed
RESULTS : The prevalence of vagal reflex on patients in treatment group was significantly lower than that in the control group , with statistically significant difference ( p & lt ; 0.05 ) ; low frequency ( LF ) and high frequency ( HF ) on patients from both groups decreased after treatment while LF / HF increased , and LF and HF on patients of the treatment group decreased more significantly and LF / HF increased more significantly than those of the control group , with statistically significant difference ( p & lt ; 0.05 ) ; the concentration of TNF - alpha and IL-6 on both groups of patients after nursing also decreased , and the treatment group decreased more significantly , with statistically significant difference ( p & lt ; 0.05 ) . - pubmed
LTRs with hepatic steatosis had higher serum concentrations of small - dense low - density lipoprotein cholesterol ( sdLDL - C ; 34.8 + - 16.9 versus 22.7 + - 11.2 mg / dL ; P & lt ; 0.001 ) , sdLDL - C to low - density lipoprotein cholesterol ratio ( 32.6 + - 11.6 versus 24.6 + - 10.2 ; P & lt ; 0.01 ) , small - dense low - density lipoprotein particle concentration ( sdLDL - P ; 770 + - 440 versus 486 + - 402 nmol / L ; P & lt ; 0.01 ) , very low density lipoprotein particle concentration ( VLDL - P ; 7.90 + - 7.91 versus 3.86 + - 3.18 nmol / L ; P & lt ; 0.01 ) , and very low density lipoprotein size ( VLDL - size ; 51.9 + - 6.4 versus 48.7 + - 6.3 nm ; P = 0.06 ) . - pubmed
LTRs with hepatic steatosis had higher serum insulin concentrations ( 27.8 + - 41.8 versus 11.7 + - 7.8 uU / mL ; P & lt ; 0.01 ) but similar fasting glucose and hemoglobin A1c . - pubmed
Steatosis grade was directly related to sdLDL - C , sdLDL - P , insulin , VLDL - P , and VLDL - size . - pubmed
In multivariate analysis , the association between steatosis grade and sdLDL - C ( beta = 0.03 ; P = 0.029 ) , VLDL - size ( beta = 0.316 ; P = 0.04 ) , and low - density lipoprotein particle size ( beta = -0.27 ; P = 0.05 ) was independent of sex , body mass index , age , diabetes mellitus , time from transplant , and indication for LT . - pubmed
IL-22 promotes the proliferation of cancer cells in smoking colorectal cancer patients . - pubmed
We found that the serum concentrations of CRC nonsmokers and CRC smokers were skewed toward Th17 - type cytokines , including interleukin ( IL )- 17 and IL-22 . - pubmed
Notably , smoking CRC subjects had significantly higher levels of IL-22 than nonsmoking CRC patients . - pubmed
We also observed higher percentages of CCR4(+)CCR6(+ ) Th17 cells in circulating blood and higher secretion of IL-17 and IL-22 by peripheral blood mononuclear cells ( PBMCs ) of nonsmoking CRC and smoking CRC patients , compared to healthy individuals . - pubmed
Again , we observed elevated IL-17 and IL-22 secretion by CRC smokers than nonsmokers . - pubmed
Since IL-22 has been shown to stimulate tumorigenesis , which was also replicated in our experiments using cancer cell line model , we tested whether CRC patients ' cell culture supernatant could also support tumor growth using this model . - pubmed
In addition , we found that the IL-22 concentration in normal gut tissue of the smoking CRC patients was significantly increased compared to that in nonsmoking CRC subjects , while no significant differences were observed in tumor tissues . - pubmed
Our results suggest that chronic smokers may have higher risk for CRC and worse prognosis due to dysregulated IL-22 production . - pubmed
Endoscopic resection ( ER ) of undifferentiated - type early gastric cancer ( UD - EGC ) has a lower curative resection ( CR ) rate than does ER of differentiated - type EGC ( D - EGC ) . - pubmed
Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant Human Hypoxia - Inducible Factor 1 - alpha ( HIF1 - alpha ) in an Ovine Model of Acute Myocardial Infarction . - pubmed
Hypoxia - inducible factor 1 - alpha ( HIF1 - alpha ) , rapidly degraded during normoxia , is stabilized during ischemia and upregulates various cardioprotective genes . - pubmed
We hypothesized that BMMSCs engineered to overexpress mutant , oxygen - resistant HIF1 - alpha would confer greater cardioprotection than nontransfected BMMSCs in sheep with AMI . - pubmed
METHODS AND RESULTS : Allogeneic BMMSCs transfected with a minicircle vector encoding mutant HIF1 - alpha ( BMMSC - HIF ) were injected in the peri - infarct of sheep ( n=6 ) undergoing coronary occlusion . - pubmed
Interferon - gamma Aggravated L - Arginine - Induced Acute Pancreatitis in Sprague - Dawley Rats and Its Possible Mechanism : Trypsinogen Activation and Autophagy Up - regulation . - pubmed
OBJECTIVES : It has been confirmed that the initiation of acute pancreatitis ( AP ) involves intracellular trypsinogen activation and local cytokines release during its early stage . - pubmed
The former is related to autophagic disorder , and the latter is resulting from nuclear factor - kappaB activation . - pubmed
However , the effects of interferon - gamma ( IFN - gamma ) on AP are controversial . - pubmed
This study is designed to elucidate the effects of IFN - gamma on AP severity and explore its impacts on the major mechanisms of AP . - pubmed
The effects of IFN - gamma on the severity of AP , trypsinogen activation peptide , and tumor necrosis factor alpha , Interleukin-1 , Interleukin-6 levels , and autophagy activity were detected . - pubmed
CONCLUSIONS : Interferon - gamma aggravated L - arginine - induced AP in Sprague - Dawley rats and led to intracellular trypsinogen activation and inflammatory response . - pubmed
The role of the transient receptor potential ankyrin type-1 ( TRPA1 ) channel in migraine pain : evaluation in an animal model . - pubmed
BACKGROUND : Clinical and experimental studies have pointed to the possible involvement of the transient receptor potential ankyrin type-1 ( TRPA1 ) channels in migraine pain . - pubmed
In this study , we aimed to further investigate the role of these channels in an animal model of migraine using a novel TRPA1 antagonist , ADM _ 12 , as a probe . - pubmed
The expression levels of the genes coding for c - Fos , TRPA1 , calcitonin gene - related peptide ( CGRP ) and substance P ( SP ) in peripheral and central areas relevant for migraine pain were analyzed . - pubmed
CONCLUSIONS : These findings support a critical involvement of TRPA1 channels in the pathophysiology of migraine , and show their active role in counteracting hyperalgesia at the trigeminal level . - pubmed
L - mimosine induces caspase-9 - mediated apoptosis in human osteosarcoma cells . - pubmed
Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response . - pubmed
A long functional isoform of leptin receptor , LepRb , was detected in the carotid body ( CB ) , a key peripheral hypoxia sensor . - pubmed
However , the effect of leptin on minute ventilation ( VE ) and the hypoxic ventilatory response ( HVR ) has not been sufficiently studied . - pubmed
Leptin increased carotid sinus nerve activity at baseline and in response to hypoxia in vivo . - pubmed
We conclude that leptin acts on LepRb in the CBs to stimulate breathing and HVR , which may protect against sleep disordered breathing in obesity . - pubmed
The objectives of the current study were ( 1 ) to examine the effect of subcutaneous leptin infusion on minute ventilation ( VE ) and the hypoxic ventilatory response to 10 % O2 ( HVR ) in C57BL/6J mice before and after CB denervation ; ( 2 ) to express LepRb in CB of LepRb -deficient obese db / db mice and examine its effects on breathing during sleep and wakefulness and on HVR . - pubmed
In C57BL/6J mice , leptin increased VE from 1.1 to 1.5 mL / min / g during normoxia ( P & lt ; 0.01 ) and from 3.6 to 4.7 mL / min / g during hypoxia ( P & lt ; 0.001 ) , augmenting HVR from 0.23 to 0.31 mL / min / g / Delta F I O 2 ( P & lt ; 0.001 ) . - pubmed
In db / db mice , LepRb expression in CB increased VE from 1.1 to 1.3 mL / min / g during normoxia ( P & lt ; 0.05 ) and from 2.8 to 3.2 mL / min / g during hypoxia ( P & lt ; 0.02 ) , increasing HVR . - pubmed
We conclude that leptin acts in CB to augment VE and HVR , which may protect against sleep disordered breathing in obesity . - pubmed
C - reactive protein and procalcitonin profile in ventilator - associated lower respiratory infections . - pubmed
The aim of this study was to evaluate the ability of C - reactive protein ( CRP ) and procalcitonin ( PCT ) to differentiate between VAT and VAP . - pubmed
Patients with the diagnosis of VAT or VAP microbiologically documented and with one measurement of CRP and/or PCT on the day of diagnosis were included . - pubmed
On the day of infection diagnosis , the median CRP was elevated in both groups but significantly higher in VAP ( 18 mg / dL vs. 14 mg / dL , p = .001 ) . - pubmed
CONCLUSION : Although PCT and CRP presented lower values in VAT as compared to VAP , there was a marked overlap of both biomarkers values in both VA - LRTI not allowing adequate discrimination . - pubmed
A Case of IgG4 - Related Aortitis and Pericarditis : Diagnostic Challenges and Natural History . - pubmed
CASE REPORT In this case , incidental discovery of non - infectious aortitis and pulmonary mass lesions were the specific signs that led to the consideration of IgG4 - RD . - pubmed
Plasma Abeta42 / 40 Ratio Detects Early Stages of Alzheimer ' s Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study . - pubmed
OBJECTIVES : This study evaluated the potential of plasma beta - amyloid ( Abeta ) biomarkers in identifying early stages of AD and predicting cognitive decline over the following two years . - pubmed
DESIGN : Total plasma Abeta42 / 40 ratio ( TP42/40 ) was determined in 83 cognitively normal individuals ( CN ) and 145 subjects with amnestic mild cognitive impairment ( a - MCI ) stratified by an FDG - PET AD - risk pattern . - pubmed
Low TP42 / 40 at baseline increased the risk of progression to dementia by 70 % . - pubmed
CONCLUSIONS : TP42 / 40 demonstrated value in the identification of individuals suffering a - MCI , in the prediction of progression to dementia , and in the detection of underlying AD pathology revealed by FDG - PET , Amyloid - PET and CSF biomarkers , being , thus , consistently associated with all the well - established indicators of AD . - pubmed
Dissected peripancreatic tissue margin is a critical prognostic factor and is associated with a K - ras gene mutation in pancreatic ductal adenocarcinoma . - pubmed
We previously reported that the dissected pancreatic tissue margin ( DPM ) and the preoperative serum level of carbohydrate antigen 19 - 9 ( preCA19 - 9 ) were independent prognostic factors in pancreatic ductal adenocarcinoma ( PDAC ) . - pubmed
K - ras gene mutation was significantly associated with DPM ( P=0.0002 ) , and DPM - positive patients demonstrated recurrence of distant metastasis in 67 % of cases . - pubmed
Furthermore , to the best of our knowledge , the current study was the first to discover that DPM can represent a poor prognosis based putatively on its association with the K - ras gene mutation . - pubmed
The target of immune - checkpoint blocking is cytotoxic T lymphocyte protein-4 ( CTLA-4 ) or blockade of programmed death-1 ( PD-1 ) protein and its ligand programmed death ligand 1 ( PD - L1 ) that they have been considered as cancer immunotherapy in recent years . - pubmed
A Novel Diagnostic Method for Thyroid Follicular Tumors Based on Immunofluorescence Analysis of p53 - Binding Protein 1 Expression : Detection of Genomic Instability . - pubmed
It was previously demonstrated that p53 - binding protein 1 ( 53BP1 ) expression , based on immunofluorescence ( IF ) , can serve as a valuable biomarker to estimate the malignant potential of various cancers . - pubmed
This study aimed to elucidate the utility of 53BP1 NF expression as a biomarker to differentiate follicular tumors ( FTs ) . - pubmed
Methods : Associations between 53BP1 expression based on IF and histological types of FTs were analyzed using 27 follicular adenomas ( FAs ) , 28 minimally invasive FCs , and 14 widely invasive FCs . - pubmed
Results : This study demonstrates differences in 53BP1 NF expression between FA and FC . - pubmed
Thus , based on a comparison of these two indicators of GIN , 53BP1 NF ( by IF ) was better able to estimate the malignancy of FTs compared to CNA ( by array comparative genomic hybridization ) . - pubmed
Interestingly , IF revealed a heterogenous distribution of 53BP1 NF , which occurred more frequently in the invasive or subcapsular area than in the center of the tumor , suggesting intratumoral heterogeneity of GIN in FTs . - pubmed
Conclusions : It is proposed that IF analysis of 53BP1 expression could be a novel diagnostic method to estimate the malignant potential of FTs . - pubmed
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen - Induced Liver Injury . - pubmed
FXR ligands have shown effective in reducing liver injury in several experimental and clinical settings . - pubmed
This characterization resulted in the identification of a potent FXR agonist , compound 20 that was orally active , and rescued mice from acute liver failure caused by acetaminophen overdose in a FXR - dependent manner . - pubmed
Immunofluorescence analysis for transforming growth factor beta ( TGF - beta ) pathway proteins was performed on the piriform cortex of epileptic dogs . - pubmed
A significantly higher cerebrospinal fluid to serum albumin ratio was found in dogs with BBBD relative to dogs with intact blood - brain barrier ( BBB ) . - pubmed
Immunohistochemistry results suggested active TGF - beta signaling and neuroinflammation in the piriform cortex of dogs with IE , showing increased levels of serum albumin colocalized with glial acidic fibrillary protein and pSMAD2 in an area where BBBD had been detected by linear DCE - MRI . - pubmed
The agent targets ALK , which is found on neuroblastoma cells but not healthy cells , delivering a drug that causes DNA cross - links . - pubmed
Researchers have found that the antibody - drug conjugate kills ALK - expressing cells in vitro and increases survival in mouse models of neuroblastoma . - pubmed
Novel GDAP1 Mutation in a Vietnamese Family with Charcot - Marie - Tooth Disease . - pubmed
Background : Mutations of GDAP1 gene cause autosomal dominant and autosomal recessive Charcot - Marie - Tooth ( CMT ) disease and over 80 different mutations have been identified so far . - pubmed
This study analyzed the clinical and genetic characteristics of a Vietnamese CMT family that was affected by a novel GDAP1 mutation . - pubmed
Discussion : Our study expands the mutational spectrum of GDAP1 - related CMT disease with the new and unreported GDAP1 variant . - pubmed
Alterations in GDAP1 gene should be evaluated as CMT causing variants in the Vietnamese population , predominantly axonal form of neuropathy in CMT disease . - pubmed
Overexpression of LncRNA GHET1 predicts an unfavourable survival and clinical parameters of patients in various cancers . - pubmed
Recently , increasing studies have reported that long non - coding RNA ( lncRNA ) gastric carcinoma highly expressed transcript 1 ( GHET1 ) is highly expressed in variety of cancers and relevant to poor prognosis of cancer patients . - pubmed
Nevertheless , the results were inconsistent and the systematic analysis of lncRNA GHET1 in cancers has not been inspected . - pubmed
Thus , we aim to evaluate the relationship between lncRNA GHET1 expression and clinical outcomes in human cancers . - pubmed
The pooled results of this study indicated that high lncRNA GHET1 expression level was significantly associated with poor overall survival ( OS , HR = 2.30 , 95 % CI : 1.75 - 3.02 ) in human cancers . - pubmed
In addition , the elevated lncRNA GHET1 expression was also significantly related to more advanced clinical stage , earlier lymph node metastasis , earlier distant metastasis and bigger tumour size . - pubmed
LncRNA GHET1 may serve as a promising biomarker for prognosis in Asians with cancers . - pubmed
We further found that luteolin supplementation protected mice from insulin resistance induced by HFD consumption ; this improved insulin resistance was correlated with reductions in CD11c+ adipose tissue macrophages . - pubmed
Cohesin - dependent regulation of gene expression during differentiation is lost in Cohesin - mutated myeloid malignancies . - pubmed
Cohesin complex disruption alters gene expression and Cohesin mutations are common in myeloid neoplasia , suggesting a critical role in hematopoiesis . - pubmed
Together with corroborative findings in acute myeloid leukemia and myelodysplastic syndrome patient samples , these data suggest Cohesin - mediated alleviation of Etv6 repression is required for dynamic expression at critical erythroid genes during differentiation and how this may be perturbed in myeloid malignancies . - pubmed
Correction to : Serum exosomal - annexin A2 is associated with African - American triple - negative breast cancer and promotes angiogenesis . - pubmed
Prognostic role of alpha - fetoprotein in patients with hepatocellular carcinoma treated with repeat transarterial chemoembolisation . - pubmed
CONCLUSION : Serum AFP level following initial treatment in patients undergoing repeat TACE for HCC is a simple and useful clinical prognostic marker . - pubmed
We tested how adjuvants effect in a cancer vaccine model using an epitope derived from an autoactivation loop of membrane - type protease serine protease 14 ( PRSS14 ; loop metavaccine ) in mouse mammary tumor virus ( MMTV)-polyoma middle tumor - antigen ( PyMT ) system and in 2 other orthotopic mouse systems . - pubmed
Survival analysis of breast cancer patients showed that eosinophil chemokines can be useful prognostic factors in PRSS14 positive patients . - pubmed
These data suggest that melatonin may be a useful therapeutic agent to reduce cocaine abuse ; additionally , they suggest that MT1 and MT2 receptors could be therapeutic targets , useful for the treatment of drug abuse disorder . - pubmed
microRNA-383 suppresses the PI3K - AKT - MTOR signaling pathway to inhibit development of cervical cancer via downregulating PARP2 , " by Peng Teng , Yan Jiao , Min Hao , Xin Tang , J Cell Biochem . - pubmed
High antibody levels to the mycobacterial fibronectin - binding antigen of 30 - 31 kD in tuberculosis and lepromatous leprosy . - pubmed
Immunoblot assays showed that mycobacterial fibronectin - binding antigens are important targets of the humoral immune response in tuberculosis and leprosy . - pubmed
Using culture filtrate antigens of Mycobacterium tuberculosis , strong reactivity with the fibronectin - binding of 30 - 31 kD ( Fn 30 - 31 ) was demonstrated in 55.9 % of tuberculosis sera and in 56.5 % of lepromatous leprosy sera . - pubmed
Reactivity of tuberculosis and lepromatous leprosy sera with the fibronectin - binding antigen of 58 - 60 kD ( Fn 58 - 60 ) was less conspicuous . - pubmed
tuberculosis Fn 30 - 31 , which elicits a high antibody response in lepromatous leprosy but not in tuberculoid leprosy . - pubmed
Histology revealed a continuous spectrum in which ' gliosarcomas ' with large reticulin - rich areas of spindle cells merged with typical glioblastomas containing only small islands of spindle cells and reticulin staining . - pubmed
Immunocytochemistry for glial fibrillary acidic protein ( GFAP ) ; S100 protein and alpha - smooth muscle actin ( ASMA ) showed that the majority of cells in reticulin - poor areas of ' gliosarcoma ' and glioblastomas expressed S100 protein and GFAP ; many expressed ASMA and some expressed both GFAP and ASMA . - pubmed
Spindle cells in reticulin - rich areas of ' gliosarcomas ' and glioblastomas most frequently expressed ASMA but many cells also expressed S100 protein and GFAP ; some cells expressed both GFAP and ASMA . - pubmed
In the 48 - h exposure test , the cytotoxic effect of MGb2 - MMC upon target cells was similar to that of free MMC , but much greater than that of normal mouse immunoglobulin - MMC conjugate . - pubmed
When we treated the monolayers with drugs commonly used for the treatment of inflammatory bowel disease , including prednisolone , 5 - aminosalicylic acid , metronidazole , and 6 - mercaptopurine , we were not able to demonstrate a reduction in carrageenan - induced cell injury ; however , catalase at 1 mg / ml decreased carrageenan cytotoxicity . - pubmed
Drugs commonly used to treat inflammatory bowel disease do not inhibit carrageenan injury in this cell model system , although catalase does decrease injury . - pubmed
Cushing ' s syndrome , caused by ectopic ACTH production during Zollinger - Ellison syndrome , raises difficult therapeutic problems . - pubmed
In a short term study with 200 micrograms SMS bid , symptoms of hypercorticism disappeared while cortisol and ACTH serum concentrations fell below the normal values . - pubmed
Ganglionic , spinal cord and hypothalamic atrial natriuretic factor : its distribution , origin and possible role in spontaneously hypertensive rats . - pubmed
In spontaneously hypertensive rats ( SHR ) we found an elevated ANF - C content in all tissues along the pathway of increased efferent sympathetic outflow , which is present in this animal model . - pubmed
Prognostic value of CEA and ferritin assay in breast cancer : a multivariate analysis . - pubmed
The prognostic significance of preoperative serum carcinoembryonic antigen ( CEA ) and ferritin levels was evaluated in 191 women operated for breast cancer . - pubmed
Axillary node status ( P = 0.004 ) , CEA level ( P = 0.011 ) , and the histological grade of the tumor ( P = 0.029 ) emerged as independent prognostic factors . - pubmed
By contrast , no significant relationship was found between ferritin and disease - free survival . - pubmed
The data showed that the prognosis of patients with different combinations of node status and tumor grade was related to the level of CEA . - pubmed
Only women with very good ( node - negative with well - differentiated tumors ) or very bad prognosis ( node - positive with four or more metastatic nodes and poorly differentiated tumors ) had a disease - free survival independent of CEA values . - pubmed
The chemical carcinogen - induced enzyme , GDP - fucose : GM1 alpha 1 - --- 2 fucosyltransferase in rat liver and hepatoma : modulation by and association with phospholipids . - pubmed
active and passive light physical activity ) on the plasmatic cholesterol , HDL - cholesterol , triglycerides contents and on beta / alpha lipoproteins ratio as well in a group of 62 patients ( 39 males and 23 females ) with neuromotor lesions are reported . - pubmed
Intracerebroventricular injection of ostrich beta - endorphin to satiated pigeons induces hyperphagia but not hyperdipsia . - pubmed
Evaluation of prostate specific acid phosphatase and prostate specific antigen in identification of prostatic cancer . - pubmed
The peroxidase - anti - peroxidase technique was used to stain for prostate specific acid phosphatase and prostate specific antigen in 12 patients with primary tumors and in 12 patients with metastases in whom the nature of the tumor was in doubt after routine histopathological studies . - pubmed
Nine of the primary tumors were positive for both markers and an additional 2 tumors stained for prostate specific antigen only . - pubmed
The heterogeneity of the tumors in regard to these 2 prostate markers is demonstrated , and the value of staining for prostate specific acid phosphatase and prostate specific antigen is emphasized . - pubmed
We therefore urge careful examination to detect amyloid deposits of all kidney biopsy specimens of minor glomerular abnormalities , or glomerulonephritis with IgA deposits from elderly patients with nephrotic syndrome . - pubmed
Immunohistochemically , the tumor cells demonstrated positive reactivity for high molecular weight keratin and glandular lumina membrane positivity for EMA , which support a collecting duct origin for the tumor . - pubmed
Histological difference between complete responders and non - responders to interferon therapy of the livers of patients with chronic hepatitis C. - pubmed
Liver histology was compared in patients with chronic hepatitis C to note the differences between responders and non - responders to interferon treatment . - pubmed
Nicotinic and muscarinic receptors have been visualized in normal and AD brains . - pubmed
When an AD patient with moderate dementia was treated with nerve growth factor ( NGF ) PET studies revealed increase in cortical blood flow and nicotinic receptors . - pubmed
A point mutation in the bile acid biosynthetic enzyme sterol 27 - hydroxylase in a family with cerebrotendinous xanthomatosis . - pubmed
An examination was made of the cDNA encoding cytochrome P450 sterol 27 - hydroxylase ( CYP27 ) in hepatic mitochondria , considered a defective enzyme inducing CTX , in a Japanese housewife afflicted with CTX and her family . - pubmed
The proposita and one of her brothers , who also had CTX symptoms and hypercholestanolemia , were found to be homozygotic , carrying a point mutation in the CYP27 gene at Arg104 ( CGG ) to Trp104 ( TGG ) . - pubmed
An increase in plasma cholestanol alone would , thus , not appear to be a direct cause of sterol storage in CTX , while CTX is strongly suggested to be caused by defects in both alleles of the CYP27 gene . - pubmed
From the sera of patients with advanced cancer , a novel factor called SDF ( serum - derived factor ) was partially purified . - pubmed
We concluded that SDF might be a novel factor associated with the clinical features of advanced cancer . - pubmed
It is speculated that SDF might have some role in disease progression of AIDS as well as in the development of the cachectic conditions in AIDS associated with malignancies . - pubmed
PC3 ( pheochromocytoma cell-3 ) is an immediate early gene isolated as sequence induced in the rat PC12 cell line during neuronal differentiation by nerve growth factor ( NGF ) . - pubmed
In stable NIH3T3 clones expressing PC3 , the transition from G1 to S phase was impaired , whereas the retinoblastoma ( RB ) protein was detected as multiple isoforms of M(r ) 105,000 - 115,000 ( indicative of a hyperphosphorylated state ) only in low - density cultures . - pubmed
Systemic vasopressin ( V1 ) receptor blockade did not inhibit the pressor response , and rats with central diabetes insipidus ( DI / DI ) displayed an identical rise in MAP . - pubmed
CR1 density polymorphism and expression on erythrocytes of patients with systemic lupus erythematosus . - pubmed
The present study investigated the expressed number of CR1 on erythrocytes ( E ) in relationship of the CR1 density genotype from 46 patients with systemic lupus erythematosus ( SLE ) and 47 healthy volunteers . - pubmed
Our data supported the earlier results that the number of binding sites / E for monoclonal anti - CR1 decreased among SLE patients compared with normal individuals having the same alleles for the CR1 / E density . - pubmed
At the same time the novelty of our recent results was that the decreased expression of CR1 on E correlated significantly with kidney involvement in patients homozygous for the CR1 / E high density allele ( HH ) . - pubmed
These data suggest that the deficiency of the detectable number of CR1 on erythrocytes is acquired in this SLE population . - pubmed
We reviewed here that protein isomerization is enhanced in amyloid - beta peptides ( Abeta ) and paired helical filaments ( PHFs ) purified from Alzheimer ' s disease ( AD ) brains . - pubmed
We show here that PIMT is upregulated in neurodegenerative neurons and colocalizes in neurofibrillary tangles ( NFTs ) in AD . - pubmed
Taken together with the enhanced protein isomerization in AD brains , it is implicated that the upregulated PIMT may associate with increased protein isomerization in AD . - pubmed
We also reviewed studies on PIMT - deficient mice that confirmed that PIMT plays a physiological role in the repair of isomerized proteins containing L - isoaspartate . - pubmed
p53 tumor suppressor is a subject of several post - translational modifications , including phosphorylation , ubiquitination and acetylation , which regulate p53 function . - pubmed
[ Expression of ICAM-1 / LFA-1 in the pocket area of adult periodontitis ] . - pubmed
OBJECTIVE : To study the expression of ICAM-1 / LFA-1 in the pocket area of adult periodontitis . - pubmed
METHODS : Expressions of ICAM-1 / LFA-1 in adult gingival of periodontitis and healthy subjects were studied by alkaline phosphorylase - antialkaline phosphorylase technique . - pubmed
RESULTS : Junctional epithelium and apical part of sulcus epithelium expressed ICAM-1 in both adult periodontitis and healthy gingiva , showing an ICAM-1 gradient change with maximal staining at tooth aspect and weaker staining in the basal layer of keratinocytes . - pubmed
Significantly more LFA-1 positive leukocytes were observed in connective tissues and within pocket epithelium in adult periodontitis than those in healthy gingiva . - pubmed
CONCLUSION : ICAM-1 / LFA-1 may provide important adhesion pathway for leukocytes migration into gingiva sulcus in adult periodontitis lesions . - pubmed
Forty - six percent were ER positive ( median , 16 fmol / mg protein ; range , 5 - 1017 fmol / mg ) , and 35 % were PgR positive ( median , 61 fmol / mg protein ; range , 6 - 854 fmol / mg ) . - pubmed
CONCLUSIONS : We underscore the utility of combined cavernous lavage + adjuvant alpha-1 adrenergic agonist as initial therapy in priapism with this special etiology . - pubmed
The expression of the proteins ERBB2 , JUN , RAS and tissue factor was significantly higher in adenocarcinomas compared to squamous cell lung carcinomas . - pubmed
In contrast , all resistance proteins analyzed were more frequently expressed in squamous cell lung carcinomas in comparison to adenocarcinomas , though only GST - pi reached statistical significance . - pubmed
These methods provide valuable tools to forward our understanding of the role of NF - kappaB in plasticity as well as in many neurological disorders being mimicked by in vitro studies . - pubmed
The aim of this study was to evaluate the relationship between the rate of fibrosis progression and the sustained virologic response ( SVR ) to interferon ( IFN)-based treatment . - pubmed
Hence the rate of fibrosis progression is an independent predictor of SVR to IFN - based therapy in patients with chronic hepatitis C. - pubmed
Anti - thrombin , anti - platelet and anti - vitamin K agents are common treatments given for the prevention of thrombotic or embolic events . - pubmed
The lack of suppressor of cytokine signalling-1 ( SOCS1 ) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA . - pubmed
Cerebral malaria is a severe complication of infection with Plasmodium berghei ANKA involving the Th1 cytokines TNF - alpha and IFN - gamma . - pubmed
Contrary to the expectation that SOCS1 - deficient mice , in which IFN - gamma responses are uncontrolled and which are more sensitive to IFN - gamma , may show heightened susceptibility , mice lacking SOCS1 were protected from cerebral malaria . - pubmed
Unlike the controls and despite similar parasitaemia , infected SOCS1 null mice showed no inflammation or haemorrhaging in the brains . - pubmed
Mice lacking SOCS1 exhibited decreased splenic cellularity and a reduced ratio of CD4 : CD8 lymphocytes , which were maintained during infection . - pubmed
However , the ratio of IFN - gamma to IL-4 mRNA expression during infection was similar in SOCS1 -/- and control mice suggesting that a dramatic shift in the ratio of Th1 : Th2 responses does not account for the resistance to disease . - pubmed
Understanding the mechanism by which SOCS1 deficiency protects mice from cerebral malaria may allow the manipulation of its activity and alleviate pathology . - pubmed
HORTON ' S SYNDROME , A GENETIC DISEASE : The preferential association of the disease with some alleles pf the HLA DR4 group has helped to emphasize the fundamental role of a few amino acids of the second hypervariable area of the HLA - DR molecule . - pubmed
Moreover , intimal hyperplasia ( mediated by the PDGF ( platelet derived growth factor ) A and B ) and thrombosis ( related to the inflammation ) join up in reducing the arterial flow and enhancing the risk of ischemic complications during the acute stage . - pubmed
PATHOGENESIS , HYPOTHESES : Various candidate - antigens have been incriminated in the onset of the inflammatory reaction during Horton ' s syndrome . - pubmed
p53 immunostaining pattern in Brazilian patients with hepatocellular carcinoma . - pubmed
The tumor suppressor gene p53 is mutated in highly variable levels ( 0 - 52 % ) of HCC in different countries . - pubmed
OBJECTIVE : The objective of the present study was to compare the frequency of aberrant immunohistochemical expression of p53 in HCC occurring in cirrhotic or in non - cirrhotic patients as well as in liver cell dysplasia and in adenomatous hyperplasia . - pubmed
Nontumorous areas either in the vicinity of HCC or in the 30 purely cirrhotic cases showed no nuclear p53 altered expression , even in foci of dysplasia or adenomatous hyperplasia . - pubmed
CONCLUSION : The therapeutic effect of JGG in treating postmenopausal osteoporosis might be related with its regulation on the two kinds of protein , RHAMM and ATP1b3 . - pubmed
Nuclear factor - kappaB activation correlates with better prognosis and Akt activation in human gastric cancer . - pubmed
PURPOSE : Because the biological significance of constitutive nuclear factor - kappaB ( NF - kappaB ) activation in human gastric cancer is unclear , we undertook this study to clarify the regulatory mechanism of NF - kappaB activation and its clinical significance . - pubmed
EXPERIMENTAL DESIGN : Immunohistochemistry for NF - kappaB / RelA was done on 290 human gastric carcinoma specimens placed on tissue array slides . - pubmed
The correlations between NF - kappaB activation and clinicopathologic features , prognosis , Akt activation , tumor suppressor gene expression , or Bcl-2 expression were analyzed . - pubmed
We also did luciferase reporter assay , Western blot analysis , and reverse transcription - PCR using the SNU-216 human gastric cancer cell line transduced with retroviral vectors containing constitutively active Akt or the NF - kappaB repressor mutant of IkappaBalpha . - pubmed
RESULTS : Nuclear expression of RelA was found in 18 % of the gastric carcinomas and was higher in early - stage pathologic tumor - node - metastasis ( P = 0.019 ) . - pubmed
A negative correlation was observed between NF - kappaB activation and lymphatic invasion ( P = 0.034 ) and a positive correlation between NF - kappaB activation and overall survival rate of gastric cancer patients ( P = 0.0228 ) . - pubmed
In addition , NF - kappaB activation was positively correlated with pAkt ( P = 0.047 ) , p16 ( P = 0.004 ) , adenomatous polyposis coli ( P & lt ; 0.001 ) , Smad4 ( P = 0.002 ) , and kangai 1 ( P & lt ; 0.001 ) expression . - pubmed
An in vitro study showed that NF - kappaB activity in gastric cancer cells is controlled by and controls Akt . - pubmed
CONCLUSIONS : NF - kappaB activation was frequently observed in early - stage gastric carcinoma and was significantly correlated with better prognosis and Akt activation . - pubmed
These findings suggest that NF - kappaB activation is a valuable prognostic variable in gastric carcinoma . - pubmed
In vitro , inhibition of NTE activity by organophosphates is correlated with inhibition of neurite initiation and reduction of neurite length , supporting the hypothesis that organophosphate - induced neurological disorders are caused by inhibition of NTE activity . - pubmed
However , there is no direct evidence for the involvement of NTE in organophosphate - induced impairment of neurites in vitro . - pubmed
Selective inhibitors of the cyclooxygenase-2 enzyme were developed to treat pain and inflammation while reducing the risk of the serious gastrointestinal side effects seen with nonselective nonsteroidal anti - inflammatory drugs ( NSAIDs ) . - pubmed
Heme deficiency is associated with senescence and causes suppression of N - methyl - D - aspartate receptor subunits expression in primary cortical neurons . - pubmed
BNP as a marker of the heart failure in the treatment of imatinib mesylate . - pubmed
Since its introduction 6 years ago , imatinib mesylate , a selective tyrosine kinase inhibitor , has been a phenomenon in treating chronic myelogenous leukemia ( CML ) with remarkably superior cytogenetic and molecular response rates at all stages of CML followed by longer progression free survival . - pubmed
Here we , for the first time , report development of heart failure in patients on imatinib mesylate medication and the possibility of brain natriuretic peptide ( BNP ) as a potential diagnostic ( or predicting ) marker for heart failure . - pubmed
Since plasma BNP levels in the two patients were exceptionally high , we then explored the possibility of genetic association of BNP with the development of heart failure to find no positive association . - pubmed
Bilateral risk - reducing oophorectomy ( BRRO ) is widely used for cancer risk reduction in women with BRCA1 and BRCA2 ( BRCA1 / 2 ) mutations . - pubmed
A genome - wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 ( PDE11A ) in individuals with adrenocortical hyperplasia . - pubmed
Increased cyclic AMP ( cAMP ) signaling has been associated with PRKAR1A or GNAS mutations and leads to adrenocortical tumors and Cushing syndrome . - pubmed
Tumor tissues showed 2q31 - 2q35 LOH , decreased protein expression and high cyclic nucleotide levels and cAMP - responsive element binding protein ( CREB ) phosphorylation . - pubmed
PDE11A codes for a dual - specificity PDE that is expressed in adrenal cortex and is partially inhibited by tadalafil and other PDE inhibitors ; its germline inactivation is associated with adrenocortical hyperplasia , suggesting another means by which dysregulation of cAMP signaling causes endocrine tumors . - pubmed
Specific caspase inhibitor Q - VD - OPh prevents neonatal stroke in P7 rat : a role for gender . - pubmed
In the present study , a third generation dipeptidyl broad - spectrum caspase inhibitor , quinoline - Val - Asp ( Ome )- CH2 - O - phenoxy ( Q - VD - OPh ) , was tested in a model of unilateral focal ischaemia with reperfusion in 7 - day - old rats . - pubmed
Following ischaemia in P7 rats , males and females displayed different time course and pattern of cytochrome c release and active p17 caspase 3 during the first 24 h of recovery . - pubmed
Effects of ERBB2 amplicon size and genomic alterations of chromosomes 1 , 3 , and 10 on patient response to trastuzumab in metastatic breast cancer . - pubmed
Trastuzumab is widely used for advanced breast cancer patients with ERBB2 - amplified tumors . - pubmed
In 35 patients with ERBB2 - amplified metastatic breast cancer , with 40 % overall response to trastuzumab , fluorescence in situ hybridization identified the telomeric extent of the ERBB2 amplicon and the status of the several pathway - related genes . - pubmed
However , the molecular mechanisms by which PP2A activity is inhibited in human cancers are currently unclear . - pubmed
In addition to its function in c - Myc stabilization , CIP2A promotes anchorage - independent cell growth and in vivo tumor formation . - pubmed
Importantly , CIP2A is overexpressed in two common human malignancies , head and neck squamous cell carcinoma ( HNSCC ) and colon cancer . - pubmed
Thus , our data show that CIP2A is a human oncoprotein that inhibits PP2A and stabilizes c - Myc in human malignancies . - pubmed
Association study of the brain - derived neurotropic factor ( BDNF ) gene in attention deficit hyperactivity disorder . - pubmed
Brain - derived neurotropic factor ( BDNF ) has been suggested to play a role in the pathogenesis of ADHD and two family - based association studies demonstrated an association of BDNF polymorphisms with ADHD . - pubmed
The aim of the current study was to investigate the BDNF gene for association with ADHD in a large sample of families from Toronto . - pubmed
The transmission of three polymorphisms of the BDNF gene ( rs6265 , rs11030104 , and rs2049046 ) was examined in 266 nuclear families ascertained through a proband with ADHD ( 315 affected children ) using the transmission / disequilibrium test ( TDT ) . - pubmed
In light of the evidence for an involvement of BDNF in ADHD , further analysis of the BDNF gene in ADHD is warranted . - pubmed
METHODS : We collected and prepared sera of cervical carcinoma from Uighur women , and separated and processed data using 2 - dimensional liquid phase chromatography system specific for protein ( ProteomeLab PF-2D ) . - pubmed
STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma . - pubmed
BACKGROUND : Signal transducer and activator of transcription 3 ( STAT3 ) regulates the expression of genes that mediate cell survival , proliferation , and angiogenesis and is aberrantly activated in various types of malignancies , including renal cell carcinoma ( RCC ) . - pubmed
We examined whether it could be a novel therapeutic target for RCC by using the STAT3 inhibitor WP1066 . - pubmed
RESULTS : In Caki-1 and 786 - O renal cancer cells , 5 muM WP1066 prevented the phosphorylation of STAT3 , and 2.5 muM WP1066 significantly ( P<0.01 ) inhibited cell survival and proliferation . - pubmed
WP1066 suppressed the expression of Bcl-2 , induced apoptosis , and inhibited the basal and hypoxia - induced expression of HIF1alpha and HIF2alpha , as well as vascular endothelial growth factor secretion into cell culture medium . - pubmed
Systemic oral administration of WP1066 to mice for 19 days significantly inhibited the growth of Caki-1 xenograft tumours ( P<0.05 ) , and pathological analysis of xenografts of WP1066 - treated mice showed decreased immunostaining of phosphorylated STAT3 and reduced length of CD34 - positive vessels ( P<0.05 ) . - pubmed
CONCLUSION : Our results suggest that using WP1066 to inhibit the STAT3 signalling pathway could be a novel therapeutic strategy against RCC . - pubmed
Toll - like receptor 4 stimulation triggers crescentic glomerulonephritis by multiple mechanisms including a direct effect on renal cells . - pubmed
A role for toll - like receptor 4 ( TLR4 ) has been suggested in previous studies of glomerulonephritis , but the complex integration of these effects has not been explored . - pubmed
These findings , in a single disease model , illustrate that TLR4 stimulation triggers crescentic glomerulonephritis by effects on both the adaptive and innate immune response , with a crucial direct effect on renal cells . - pubmed
Myocardial infarction leads to structural remodeling of the myocardium , in particular to the loss of cardiomyocytes due to necrosis and an increase in collagen with scar formation . - pubmed
Hirame natural embryo ( HINAE ) cells overexpressing MDA5 showed a lower cytopathic effect ( CPE ) against VHSV , hirame rhabdovirus ( HIRRV ) and infectious pancreatic necrosis virus ( IPNV ) infection . - pubmed
Bz-423 , a small - molecule inhibitor of the mitochondrial F ( 1 ) F ( 0 ) adenosine triphosphate synthase ( F ( 1 ) F ( 0 )- ATPase ) , selectively increased superoxide and induced the apoptosis of alloreactive T cells , which arrested established GVHD in several BMT models without affecting hematopoietic engraftment or lymphocyte reconstitution . - pubmed
NACP - Rep1 relates to Beck Depression Inventory scores in healthy humans . - pubmed
Alpha - synuclein ( SNCA ) is associated with a range of psychiatric diseases including neurodegeneration , alcohol craving , and depression . - pubmed
To date , it is unclear whether the previously described association between SNCA and depressive symptomatology is limited to females with eating disorders or whether it could be extended to include healthy individuals . - pubmed
BACKGROUND AND PURPOSE : The cystic fibrosis transmembrane conductance regulator ( CFTR ) is a cAMP - dependent chloride channel in the plasma membrane of epithelia whose mutation is the cause of the genetic disease cystic fibrosis ( CF ) . - pubmed
[ Effects of valproate sodium on pituitary gonadotropin in adolescent girls with epilepsy ] . - pubmed
OBJECTIVE : To study the effects of valproate sodium ( VPA ) on the level and axle of pituitary gonadotropin in adolescent girls with epilepsy . - pubmed
RESULTS : The serum levels of estradiol , follicle - stimulating hormone , luteinizing hormone and prolactin in the children with epilepsy were not significantly different during the 1 year VPA treatment compared with pretreatment . - pubmed
Remarkable reduction of MAP2 in the brains of scrapie - infected rodents and human prion disease possibly correlated with the increase of calpain . - pubmed
To obtain insight into the possible alteration and the role of MAP2 in transmissible spongiform encephalopathies ( TSEs ) , the MAP2 levels in the brain tissues of agent 263K - infected hamsters and human prion diseases were evaluated . - pubmed
Western blots and IHC revealed that at the terminal stages of the diseases , MAP2 levels in the brain tissues of scrapie infected hamsters , a patient with genetic Creutzfeldt - Jakob disease ( G114V gCJD ) and a patient with fatal familial insomnia ( FFI ) were almost undetectable . - pubmed
Our data indicate that the decline of MAP2 is a common phenomenon in TSEs , which seems to occur at an early stage of incubation period . - pubmed
The activity of these compounds on seizure control is independent of histone deacetylase inhibitory activity ( associated with the teratogenicity of VPA ) , and does not correlate with liver cell toxicity . - pubmed
The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk . - pubmed
Metabolizers of environmental carcinogenic and endogenous compounds affecting CRC risk include the phase II detoxification UDP - glucuronosyltransferase ( UGT ) enzymes UGT2B17 and UGT2B28 , which are 2 of the most commonly deleted genes in the genome . - pubmed
METHODS : To study the effect of UGT2B17 and UGT2B28 copy number variation ( CNV ) on CRC risk , 665 Caucasian CRC cases and 621 Caucasian controls were genotyped who had completed extensive demographics and lifestyle questionnaires . - pubmed
RESULTS : A significant association between the UGT2B17 deletion genotype ( 0/0 ) and decreased CRC risk was found when the entire population was analyzed ( P = .044 ) . - pubmed
A significant association between UGT2B17 ( 0/0 ) and decreased risk for rectal ( P = .0065 ) but not colon cancer was found . - pubmed
No significant association was found between UGT2B28 CNV and CRC risk . - pubmed
CONCLUSIONS : The UGT2B17 deletion genotype ( 0/0 ) was associated with a decreased CRC risk in a Caucasian population . - pubmed
Crescentic glomerulonephritis due to IgA nephropathy or propylthiouracil - induced Mpo - Anca positive vasculitis ? - pubmed
AIM : beta - Adrenoceptor blockers have been used with caution in patients with obstructive lung diseases such as asthma or chronic obstructive pulmonary disease ( COPD ) , due to the potentially increased airway reactivity and risk of bronchial obstruction . - pubmed
Cardioselective beta - adrenoceptor blockers have a more beneficial profile than non - cardioselective beta - adrenoceptor blockers and can be safely prescribed to patients with both cardiovascular disease and COPD . - pubmed
After exclusion of patients with COPD , asthma and heart failure the effects of cardioselective beta - adrenoceptor blockers remained significant for FEV1 ( -142 ml [ 95 % CI -189 , -96 ] ) and for FVC ( -176 ml [ 95 % CI -236 , -117 ] ) . - pubmed
Prospective validation of quantitative NSE mRNA in pleural fluid of non - small cell lung cancer patients . - pubmed
Based on a retrospective study of 86 curatively resected lung cancer patients ( training set ) , we determined a cutoff value of NSE mRNA using receiver - operating characteristic curve . - pubmed
CONCLUSIONS : Notably , the influenza hemagglutinin ( HA ) receptor has evolutionary conserved domains that can serve as basis for the rational design of a universal influenza vaccine . - pubmed
Neuroglobin is a brain globin with neuroprotective effects against ischemia and related pathological processes , acting as O2 sensor and antiapoptotic pathway transducer . - pubmed
Glial fibrillary acidic protein ( GFAP ) was increased whereas spinophilin and postsynaptic density ( PSD)-95 protein were decreased in the CA1 of depressed monkeys . - pubmed
Gene expression of GFAP paralleled the protein changes observed in the CA1 and was inversely related to serum estradiol levels in depressed monkeys . - pubmed
CONCLUSIONS : A therapeutic window for the clinical investigation of LY2157299 in cancer patients was defined using a targeted PK / PD approach , which integrated translational biomarkers and preclinical toxicity . - pubmed
beta ( 2 )- Adrenoreceptor blockade improves early posttrauma hyperglycemia and pulmonary injury in obese rats . - pubmed
Insulin is widely used to control posttrauma glucose , but this treatment increases the risk of hypoglycemia . - pubmed
We tested a novel method for early posttrauma hyperglycemia control by suppressing hepatic glycogenolysis via beta2 - adrenoreceptor blockade [ ICI-118551 ( ICI ) ] . - pubmed
One day after trauma , plasma IL-6 levels , lung neutrophil numbers , myeloperoxidase ( MPO ) activity , and wet - to - dry weight ratios were measured . - pubmed
ICI treatment reduced the early hyperglycemia , lung neutrophil retention , MPO activity , and wet - to - dry weight ratio in OZ rats to levels comparable with those seen in LZ rats , with no effect on blood pressure or heart rate . - pubmed
These results demonstrate that beta2 - adrenoreceptor blockade effectively reduces the early posttrauma hyperglycemia , which is associated with decreased lung injury in OZ rats . - pubmed
Invited commentary on " Evaluation of a predictive model for pancreatic fistula based on amylase value in drains after pancreatic resection " by Partelli et al . - pubmed
Adenosine A2A - D2 receptor - receptor interactions in putative heteromers in the regulation of the striato - pallidal gaba pathway : possible relevance for parkinson ' s disease and its treatment . - pubmed
In fact , the existence of putative striatalA2A / D2 receptor heteromers has been suggested to be important for striatal function under both normal and pathological conditions , such as Parkinson ' s disease . - pubmed
Consequently , the antagonistic A2A - D2 receptor interactions in a putative striatal receptor heteromer on striato - pallidal GABA neuron led to the introduction of A2A receptor antagonists as possible anti- Parkinsonian drugs . - pubmed
The possible relevance of compounds targeting the putative striatal A2A / D2 heteromer in the Parkinson ' s disease pharmacological treatment is also discussed . - pubmed
Can TIE-2 expressing monocytes represent a novel marker for hepatocellular carcinoma ? - pubmed
Mechanisms of tumor necrosis factor alpha antagonist - induced lupus in a murine model . - pubmed
OBJECTIVE : Tumor necrosis factor alpha ( TNFalpha ) antagonists are effective for treating rheumatoid arthritis and other inflammatory diseases , but their use can be complicated by the development of lupus - like phenomena . - pubmed
METHODS : Toll - like receptor 7 ( TLR-7 ) ligand - driven lupus was induced by injection of pristane into C57BL / 6 ( B6 ) mice deficient in TNFalpha ( TNFalpha(-/- ) ) or TNFalpha - intact B6 mice as wild - type controls . - pubmed
When treated with pristane , TNFalpha(-/- ) mice developed more severe lupus compared to pristane - treated controls , characterized by increased levels of anti - Sm / RNP autoantibodies , type I IFN , PDCs , and peritoneal inflammatory ( Ly-6C(high ) ) monocytes . - pubmed
In pristane - treated TNFalpha(-/- ) mice , the numbers of neutrophils , a cell type that promotes resolution of inflammation , were decreased considerably , whereas the responses of inflammatory monocytes and PDCs and the production of type I IFN were increased and prolonged . - pubmed
In humans , the rate of clearance of dead cells , along with the levels of TNFalpha , may influence who will develop lupus following treatment with TNFalpha inhibitors . - pubmed
In cluster 3 , transcription factor ESR1 was reported related with hepatocellular carcinoma . - pubmed
As a pre - metastatic niche rich in a variety of chemokines , the BM niche is turned into a locus of tumor cell development and division . - pubmed
Knowledge of chemokines and their receptors leads to the production of various therapeutic antagonists at chemokine receptors expressed on leukemic and tumor cells , enabling interference with chemokine function as a therapeutic tool . - pubmed
DDAH is an enzyme that metabolizes asymmetric dimethylarginine ( ADMA ) , an endogenous inhibitor of NO synthesis , previously shown to be elevated in the plasma of pre - eclamptic mothers . - pubmed
Both dysregulation of DDAH and the accumulation of ADMA have been associated with the development of pre - eclampsia . - pubmed
This is the first study to implicate the DDAH / ADMA pathway as a mechanism that might underlie the poor trophoblast invasion seen in this common pregnancy disorder . - pubmed
Carney triad is distinct from the dyad of paragangliomas / pheochromocytomas and gastrointestinal stromal tumors , known as Carney - Stratakis syndrome , which is inherited in an autosomal- dominant manner and is almost always caused by succinate dehydrogenase subunit mutations . - pubmed
A patient with Carney triad and SDHC variant had a ganglioneuroma . - pubmed
One of the patients with Carney triad and SDHB mutation had a nephew with the same sequence defect , who developed a neuroblastoma . - pubmed
Other relatives , carriers of the identified SDHA , SDHB or SDHC mutations , have not developed any of the components of Carney triad or Carney - Stratakis syndrome . - pubmed
None of the other 57 Carney triad patients had any genomic defects of SDHA , SDHB or SDHC genes . - pubmed
Although for the vast majority of patients with Carney triad the causative defect(s ) remain(s ) unknown , testing for SDHA , SDHB or SDHC variations should be offered , as carriers may develop isolated paragangliomas / pheochromocytomas and occasionally other tumors . - pubmed
STIM1 elevation in the heart results in aberrant Ca2 + handling and cardiomyopathy . - pubmed
STIM1 transgenic mice exhibited sudden cardiac death as early as 6weeks of age , while mice surviving past 12weeks of age developed heart failure with hypertrophy , induction of the fetal gene program , histopathology and mitochondrial structural alterations , loss of ventricular functional performance and pulmonary edema . - pubmed
New Insight on the Role of Plasminogen Receptor in Cancer Progression . - pubmed
OBJECTIVE : Plasminogen system plays a crucial role in physiological and pathological events related to tissue regeneration , wound healing , immune response , angiogenesis , invasion and metastasis . - pubmed
This review also discusses the possible effect of blocking these plasminogen receptors with monoclonal antibodies and DNA - based vaccination or silencing plasminogen receptor gene using small interfering RNA or short hairpin RNA to counteract cancer invasion and metastasis . - pubmed
Second - Trimester Maternal Serum Paraxanthine , CYP1A2 Activity , and the Risk of Severe Preeclampsia . - pubmed
OBJECTIVE : To measure the association between second - trimester maternal caffeine intake and caffeine metabolism through the CYP1A2 system and the risk of subsequent severe preeclampsia . - pubmed
The outcome of interest was severe preeclampsia , and exposures were serum paraxanthine ( 1,7 - dimethylxanthine ) , measured through high - performance liquid chromatography , and CYP1A2 activity , assessed by paraxanthine / caffeine ratios . - pubmed
A sudden rise of CRP serum values in the group A after 12 hours after application of haemostat was recorded , most probably as manifestation of the aseptic pleuritic ( Tab . - pubmed
Assessment of glutathione S - transferaseM1 ( GSTM1 ) and its polymorphisms GSTM1 null in the response to treatment with chemotherapy in advanced ovarian carcinoma . - pubmed
OBJECTIVE : To assess if the genotype of the glutathione S - transferase M1 ( GSTM1 ) enzyme and its GSTM1 null polymorphism can influence the response to chemotherapeutic treatment of advanced ovarian cancer . - pubmed
The tissue to study the GSTM1 genotype and its deletion came from surgical staging to treat ovarian cancer . - pubmed
CONCLUSION : No difference was observed in the response to treatment with chemotherapy in patients with advanced ovarian cancer , as to the GSTM1 genotype compared to its GSTM1 null polymorphism . - pubmed
Therefore , the present study was designed to examine immunomodulatory effects of BM - MSCs in the treatment of myelin oligodendrocyte glycoprotein ( MOG ) 35 - 55 - induced EAE in C57BL / 6 mice . - pubmed
Chronic inflammation is known to be associated with visceral obesity and insulin resistance and is characterized by altered levels of production of adipokines such as tumor necrosis factor - alpha ( TNF - alpha ) , interleukin-1 ( IL-1 ) , IL-6 , leptin , and adiponectin . - pubmed
These findings are consistent with the supposition that EA inhibits proliferation and/or infiltration of macrophages into the adipose tissue of obese rats and stimulates the release of IL-10 from the decreased numbers of macrophages present in adipose tissue . - pubmed
Evaluation of NOTCH3 Pro167Ser Variation in a Japanese Family with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy . - pubmed
CONCLUSIONS : Given the homogeneity of this series and the sensitivity of NGS in this low - cellularity tumor , we demonstrated for the first time a poor prognostic role of KRAS mutations . - pubmed
Mice deficient in N - acetylgalactosamine 4 - sulfate 6 - O - sulfotransferase exhibit enhanced liver fibrosis and delayed recovery from fibrosis in carbon tetrachloride - treated mice . - pubmed
Our findings demonstrate that defect in GalNAc4S-6ST , which resulted in disappearance of CS / DS containing GalNAc(4,6SO4 ) , appear to contribute to progression of liver fibrosis , delayed recovery from fibrosis , and various changes in the expression of proteoglycans and MMPs in carbon tetrachloride - treated mice . - pubmed
ATM / CHK / p53 Pathway Dependent Chemopreventive and Therapeutic Activity on Lung Cancer by Pterostilbene . - pubmed
To investigate the underlying mechanism of this superior action of pterostilbene on cancer cells , we utilized a reverse - phase protein array followed by bioinformatic analysis and found that the ATM / CHK pathway is modified by pterostilbene in a lung cancer cell line . - pubmed
To test this hypothesis , we used two molecularly defined precancerous human bronchial epithelial cell lines , HBECR and HBECR / p53i , with normal p53 and suppressed p53 expression , respectively , to represent premalignant states of squamous lung carcinogenesis . - pubmed
These results strongly support the potential chemopreventive effect of pterostilbene on p53 - positive cells during early carcinogenesis . - pubmed
However , the association between NLR and BC prognosis remains unclear . - pubmed
In conclusion , this meta - analysis suggests that NLR is a good prognostic marker for BC , and patients with a higher NLR have poorer prognoses . - pubmed
METHODS : Peripheral blood mononuclear cells from HLA - A1 and HLA - A2 HSV - seropositive hereditary hemochromatosis donors were used as the antigen source . - pubmed
Cultured cells were phenotyped and tested for cytokine production , proliferation and cytotoxicity . - pubmed
The discovery that the most abundant cholesterol oxidized metabolite in the plasma , 27 hydroxycholesterol ( 27 - OHC ) , is a selective estrogen receptor modulator ( SERM ) and an agonist of Liver X receptors ( LXR ) partially fills the void in our understanding and knowledge of the mechanisms that may link hypercholesterolemia to development and progression of breast cancer and PCa . - pubmed
The wide spectrum and repertoire of SERM and LXR - dependent effects of 27 - OHC in the context of all facets and aspects of breast cancer and prostate cancer biology are reviewed in this manuscript in a very comprehensive manner . - pubmed
Protective effects of hydrogen sulfide on portal hypertensive vasculopathy in rabbits by activating AKT - NF - kappaB pathway . - pubmed
H2S / CSE system may play an important role in remission of PH via the AKT - NF - kappaB pathway . - pubmed
Endothelial mineralocorticoid receptor contributes to systolic dysfunction induced by pressure overload without modulating cardiac hypertrophy or inflammation . - pubmed
Mineralocorticoid receptor ( MR ) antagonists block aldosterone action and decrease mortality in patients with congestive HF However , the molecular mechanisms underlying the therapeutic benefits of MR antagonists remain unclear . - pubmed
Recently , we reported that ICAM-1 regulates cardiac inflammation and cardiac function in mice subjected to transverse aortic constriction ( TAC ) . - pubmed
Whether MR specifically in endothelial cells ( EC ) contributes to the several mechanisms of pathological cardiac remodeling and cardiac dysfunction remains unclear . - pubmed
While EC - MR-/- TAC mice showed preserved systolic function and some alterations in the expression of fetal genes , the proinflammatory cytokine TNFalpha and the endothelin receptors in the LV as compared to EC - MR+/+ TAC mice , no difference was observed between both TAC groups in overall cardiac hypertrophy , ICAM-1 LV expression and leukocyte infiltration , cardiac fibrosis or capillary rarefaction , all hallmarks of pathological cardiac remodeling . - pubmed
Rats display increased pain tolerance during pregnancy due to an increase in opioid receptors in the spinal cord . - pubmed
Only 24 % of those with recorded HF symptoms followed a pathway aligned with guidelines ( echocardiogram and/or serum natriuretic peptide test and specialist referral ) , while 44 % had no echocardiogram , natriuretic peptide test or referral . - pubmed
Compelling evidence suggests a crucial role of amyloid beta peptides ( Abeta ( 1 - 40 / 42 ) ) in the etiology of Alzheimer ' s disease ( AD ) . - pubmed
by glutaminyl cyclase ( QC ) , is expected to enhance the amyloid toxicity . - pubmed
Hence , consecutive conversion of Abeta ( 1 - 40 / 42 ) by DPPIV and QC can be assumed as a potential mechanism of formation of non - degrading pyroglutamated pE - Abeta(3 - 40/42 ) , which might accumulate and contribute to AD progression . - pubmed
Expression of PD-1 / PD - L1 and PD - L2 in peripheral T - cells from non - small cell lung cancer patients . - pubmed
Binding of programmed death-1 ( PD-1 ) with its ligands ( PD - L1 / 2 ) transmits a co - inhibitory signal in activated T - cells that promotes T - cell exhaustion , leading to tumor immune evasion . - pubmed
The efficacy of antibodies targeting PD-1 and PD - L1 has led to a paradigm shift in lung cancer treatment but the prognostic and predictive value of tumor PD - L1 expression remains controversial . - pubmed
In this prospective observational study , plasma cytokine levels and PD-1 , PD - L1 and PD - L2 expression was evaluated in circulating CD3 + , CD3+CD4 + and CD3+CD8 + cells from 70 treatment - naive patients with advanced NSCLC ( Stage IIIB and IV ) and from 10 healthy donors . - pubmed
Our findings suggest that increased PD-1 / PD - L1 / PDL-2 expression in PBMCs , particularly in T - cells , may be an additional mechanism leading to tumor escape from immune control . - pubmed
UCA1 impacts progress of rheumatoid arthritis by inducing the apoptosis of fibroblast - like synoviocyte . - pubmed
PATIENTS AND METHODS : qRT - PCR was used to detect the expression of UCA1 in fibroblast - like synoviocyte from normal people and rheumatoid arthritis patients . - pubmed
RESULTS : We found that the UCA1 was highly expressed in the normal fibroblast - like synoviocyte ( NFLS ) , compared with the fibroblast - like synoviocyte of rheumatoid arthritis ( RAFLS ) . - pubmed
We also found that the decrease in UCA1 expression increased the viability in NFLS and overexpressed UCA1 level in RAFLS decreased the viability . - pubmed
What 's more , UCA1 could affect the viability of FLS by changing the expression of Wnt6 . - pubmed
CONCLUSIONS : According to the results , we found that UCA1 was closely related to rheumatoid arthritis , which could be a potential target for treating it . - pubmed
Based on the BAS score , BD who were moderately BAS - affected ( n = 5 ) , had significantly lower arterial saturation of hemoglobin with oxygen values on arterial blood gas when compared with MDD ( n = 18 ) . - pubmed
Transient receptor potential vanilloid type 1 ( TRPV1 ) is implicated in pain signaling and resides on sensory dorsal root ganglion ( DRG ) neurons . - pubmed
We investigated the expression and functional activity of TRPV1 in DRG neurons of the Ins2+/Akita mouse at 9 months of diabetes using immunohistochemistry , live single cell calcium imaging , and whole - cell patch - clamp electrophysiology . - pubmed
Although TRPV1 expressing neuron percentage was increased in Ins2+/Akita DRGs at 9 months of diabetes compared to control , capsaicin - induced Ca2 + influx was smaller in isolated Ins2+/Akita DRG neurons , indicating impaired TRPV1 function . - pubmed
We propose that in poorly controlled diabetes , the accelerated rate of capsaicin - sensitive TRPV1 current decay in DRG neurons decreases overall TRPV1 activity and contributes to peripheral neuropathy . - pubmed
Interaction of host immunity with HER2 - targeted treatment and tumor heterogeneity in HER2 - positive breast cancer . - pubmed
In addition , HER2 + breast cancer is generally considered more immunogenic than hormone receptor - positive ( HR+)/HER2- , and specific molecular HER2 + subgroups ( e.g. - pubmed
HER2 - enriched disease ) are more immunogenic than others ( e.g. - pubmed
From a clinical perspective , the immune system plays a relevant prognostic role in HER2 + breast cancer and contributes to the therapeutic effects of trastuzumab . - pubmed
Furthermore , the recent introduction in oncology of immune checkpoint inhibitors capable of unleashing anti - tumor immune response opens new possibilities for therapeutic combinations in HER2 + breast cancer . - pubmed
Here , we review the current pre - clinical and clinical data on the interplay between the immune system and HER2 + breast cancer , focusing on different HER2 - targeted treatments and the biological heterogeneity that exists within HER2 + disease . - pubmed
beta - Thalassemia ( beta - thal ) is the most frequently observed hereditary blood disorder that results from genetic defects causing deficient synthesis of hemoglobin ( Hb ) polypeptide chains . - pubmed
Chronic cadmium exposure decreases the dependency of MCF7 breast cancer cells on ERalpha . - pubmed
Cadmium is an environmental contaminant that can activate estrogen receptor alpha ( ERalpha ) and contribute to the development and progression of breast cancer . - pubmed
Our lab previously demonstrated that chronic cadmium exposure alters the expression of several ERalpha - responsive genes and increases the malignancy of breast cancer cells . - pubmed
Although these studies support cadmium 's function as a hormone disrupter , the role of ERalpha in cadmium - induced breast cancer progression remains unclear . - pubmed
To address this , we modulated the expression of ERalpha and found that while the loss of ERalpha significantly impaired cancer cell growth , migration , invasion and anchorage - independent growth in both MCF7 and MCF7 - Cd cells , cadmium - exposed cells retained a significant advantage in cell growth , migration , and invasion , and partially circumvented the loss of ERalpha . - pubmed
This is the first study to show that chronic cadmium exposure , even at low levels , can increase the malignancy of breast cancer cells by decreasing their dependency on ERalpha and increasing the adaptability of the cancer cells . - pubmed
Using cis - regulatory sequence analysis , STAT5 was identified as a regulator of DC activation and immune responses downstream of innate immune signaling that was not activated during either WNV or ZIKV infection . - pubmed
In this work , we identify STAT5 as a regulator of DC activation and antiviral immune responses downstream of innate immune signaling that was not activated during either WNV or Zika virus ( ZIKV ) infection . - pubmed
Isocitrate dehydrogenase 1 ( IDH1 ) gene mutations have been observed in a majority of diffuse astrocytomas , oligodendrogliomas , and secondary glioblastomas , and the mutant IDH1 R132H is detectable in most of these lesions . - pubmed
Immunohistochemistry ( IHC ) detection of IDH1 mutant protein may also be used to visualize single infiltrating tumor cells in surrounding brain tissue with an otherwise normal appearance . - pubmed
Celastrol - induced degradation of FANCD2 sensitizes pediatric high - grade gliomas to the DNA - crosslinking agent carboplatin . - pubmed
Since aberrant expression of DNA damage - response associated Fanconi anemia proteins play a central role in the onset and therapy resistance of many cancers , we here investigated if FANCD2 depletion could sensitize pHGG to additional DNA damage . - pubmed
METHODS : We determined the capacity of celastrol , a BBB - penetrable compound that degrades FANCD2 , to sensitize glioma cells to the archetypical DNA - crosslinking agent carboplatin in vitro in seven patient - derived pHGG models . - pubmed
FINDINGS : FANCD2 is overexpressed in HGGs and depletion of FANCD2 by celastrol synergises with carboplatin to induce cytotoxicity . - pubmed
In addition , our results suggest that celastrol treatment stalls ongoing replication forks , causing sensitivity to DNA - crosslinking in FANCD2 - dependent glioma cells . - pubmed
INTERPRETATION : Our results show that depletion of FANCD2 acts as a chemo - sensitizing strategy in pHGG . - pubmed
Immunohistochemically , the tumor cells were strongly positive for S-100 , GFAP , oligo-2 and vimentin , focally positive for synaptophysin and CD34 , and negative for cytokeratin , EMA , NeuN and IDH1 . - pubmed
A BRAF V600E mutation was then identified in the tumor . - pubmed
Based on morphologic features , the immunohistochemical staining and BRAF V600E mutation , the tumor was diagnosed as a PXA . - pubmed
Inhibin B as a screening tool for early detection and treatment monitoring of central precocious puberty . - pubmed
Anti - Mullerian hormone ( AMH ) and inhibin B are considered possible biomarkers of central precocious puberty ( CPP ) . - pubmed
The aim of this study was to evaluate serum levels of AMH and inhibin B , to investigate their regulatory patterns , and to study their clinical significance in girls with CPP . - pubmed
Inhibin B was useful for determining CPP and the therapeutic effects of GnRHa treatment in girls with CPP . - pubmed
AMH interacted , in part , with the hypothalamo - pituitary gonadal axis , but its clinical implications in CPP should be further investigated . - pubmed
lncRNA ZEB1 - AS1 inhibits high glucose - induced EMT and fibrogenesis by regulating the miR-216a-5p / BMP7 axis in diabetic nephropathy . - pubmed
Long non - coding RNA zinc finger E - box binding homeobox 1 antisense 1 ( ZEB1 - AS1 ) plays a crucial role in the development of various diseases , including DN . - pubmed
However , the molecular mechanism of ZEB1 - AS1 in DN pathogenesis remains elusive . - pubmed
Western blot assay was used to evaluate the protein levels of BMP7 , epithelial - to - mesenchymal transition ( EMT)-related proteins , and fibrosis markers . - pubmed
ZEB1 - AS1 and BMP7 were down - regulated , while miR-216a-5p was highly expressed in kidney tissues of DN patients . - pubmed
lncRNA ZEB1 - AS1 inhibited high glucose - induced EMT and fibrogenesis via regulating miR-216a-5p / BMP7 axis in diabetic nephropathy , providing a potential target for DN therapy . - pubmed
BACKGROUND : Denosumab is an inhibitor of monoclonal receptor activator of nuclear factor - kB ligand , approved to treat giant cell tumors of bone ( GCTB ) . - pubmed
HLA Class I Allele Expression and Clinical Outcome in De Novo Metastatic Prostate Cancer . - pubmed
The prognostic value of human leukocyte antigen ( HLA ) class I molecules in prostate cancer ( PCa ) remains unclear . - pubmed
Herein , we investigated the prognostic relevance of the most frequently expressed HLA - A alleles in Greece ( A*02:01 and HLA - A*24:02 ) in de novo metastatic hormone - sensitive PCa ( mPCa ) , which is a rare and aggressive disease characterized by a rapid progression to castration - resistance ( CR ) and poor overall survival ( OS ) , contributing to almost 50 % of PCa - related deaths . - pubmed
Multivariate analyses ascribed to both HLA alleles significant prognostic values for the time to progression ( TTP ) to CR and OS . - pubmed
The presence of HLA - A*02:01 and HLA - A*24:02 alleles in de novo mPCa patients are significantly and independently associated with unfavorable or favorable clinical outcomes , respectively , suggesting their possible prognostic relevance for treatment decision - making in the context of precision medicine . - pubmed
Considering the defensive role of vitamin D , mediated through modulation of the innate and adaptive immune system as well as inhibition of the Renin Angiotensin System ( RAS ) , vitamin D supplementation might boost the immune system of COVID-19 patients and reduce severity of the disease in vitamin D deficient individuals . - pubmed
Greater effect of polygenic risk score for Alzheimer ' s disease among younger cases who are apolipoprotein E - epsilon4 carriers . - pubmed
To evaluate how age and apolipoprotein E - epsilon4 ( APOE4 ) status interact with APOE - independent polygenic risk score ( PRSnon - APOE ) , we estimated PRSnon - APOE in superagers ( age > = 90 years , N = 346 ) , 89- controls ( age 60 - 89 , N = 2930 ) , and Alzheimer ' s disease ( AD ) cases ( N = 1760 ) . - pubmed
Using superagers , we see a nearly 5 times greater odds ratio ( OR ) for AD comparing the top PRSnon - APOE decile to the lowest decile ( OR = 4.82 , p = 2.5 x 10 - 6 ) , which is twice the OR as using 89- controls ( OR = 2.38 , p = 4.6 x 10 - 9 ) . - pubmed
Thus , the known AD risk variants are particularly detrimental in young APOE4 carriers . - pubmed
The application of the histochemical demonstration of AChE activity to the diagnosis of congenital megacolon ( Hirschsprung ' s disease ) is discussed , both from the point of view of the technical aspects as well as the interpretation of the results obtained , using the method of Karnovsky and Roots , as modified by El Badawi - Schenk , applied to rectal suction biopsy . - pubmed
, that the diagnosis of Hirschsprung ' s disease can be done solely with the evaluation of the AChE positive parasympathetic network of the lamina propria , with the additional consideration of the submucosal plexus to include cases of hypoganglionar megacolon , where that plexus is clearly diminished . - pubmed
These patterns were compared with those of acute ocular responses to various types of injuries caused by fromalin , bacterial endotoxins and immunological sensitization with bovine albumin . - pubmed
Genomic variability and alternative splicing generate multiple PML / RAR alpha transcripts that encode aberrant PML proteins and PML / RAR alpha isoforms in acute promyelocytic leukaemia . - pubmed
The PML / RAR alpha proteins varied among bcr1 , 2 and 3 APL cases and within single cases . - pubmed
[ Levels of blood pepsinogen I in the offspring of patients with duodenal ulcer ] . - pubmed
By establishing an upper normal value of PG I , we identified a subpopulation of normopepsinogenemic ulcerous patients and another with high values ( 9 normo PG I : 64.3 + /- 6.2 ng / ml vs 16 ulcerous patients with PG I levels : 142.1 + /- 19 ng / ml ) ( p & lt ; 0.001 ) . - pubmed
Immunoreactive transforming growth factor alpha is commonly present in colorectal neoplasia . - pubmed
Surgical specimens from 19 patients with invasive colorectal cancers and 12 specimens of normal mucosa from the same patients were examined immunohistochemically for the production of the immunoreactive ( IR- ) transforming growth factor ( TGF )- alpha and IR - epidermal growth factor ( EGF ) with an anti - TGF - alpha monoclonal antibody ( MAb ) OAL - MTG01 and anti - EGF MAb KEM-10 . - pubmed
Immunoreactive TGF - alpha was detected in 16 ( 84.2 % ) of 19 colorectal cancers . - pubmed
In contrast , there was no IR - TGF - alpha in the gland cells of normal mucosa . - pubmed
Immunoreactive EGF was detected in 7 ( 36.8 % ) of 19 colorectal cancers and 1 ( 8.3 % ) of 12 cases of normal mucosa . - pubmed
The production of both IR - TGF - alpha and IR - EGF in colorectal cancer did not differ by histologic type and Dukes ' stage . - pubmed
Immunoreactive TGF - alpha was detected at significantly higher incidence than IR - EGF in colorectal cancer . - pubmed
These results indicate that IR - TGF - alpha should prove valuable as a possible tumor marker in colorectal cancers , and it may be very useful in understanding the biology of colorectal cancer . - pubmed
This study investigated the influence of age on the pharmacokinetics , pharmacodynamics , general tolerability and concentration - effect relationships in 18 patients with essential hypertension ( age range 23 - 73 years ) during treatment with dilevalol , a non selective beta - adrenoceptor antagonist with vasodilator properties . - pubmed
Interferon therapy of chronic delta hepatitis in patients cured of pediatric malignancies : possible harmful effect . - pubmed
The severity of liver disease in many of these patients prompted us to start a pilot study on the effect of recombinant alpha 2b interferon , given at a dose of 5 MU / square meter thrice weekly . - pubmed
The results of this study , which has been interrupted at the 4th month , suggest that interferon therapy for chronic delta hepatitis has to be considered cautiously in young patients cured of pediatric malignancies . - pubmed
These were ( i ) that the eosinophil expressed Fc gamma RII ( CDw32 ) only ( unlike monocytes which bear Fc gamma RI and Fc gamma RII and neutrophils which bear Fc gamma RII and Fc gamma RIII ) ; ( ii ) that the absence of Fc gamma RIII ( CD16 ) on eosinophils served as a basis for distinguishing eosinophil and neutrophil populations by immunofluorescence ; ( iii ) that the leucocyte adhesion glycoproteins , LFA-1 alpha ( CD11a ) , CR3 - alpha ( CD11b ) , p150 , 95 - alpha ( CD11c ) and the common beta - chain ( CD18 ) , were expressed on the eosinophil as well as the neutrophil ; ( iv ) that CD18 expression was significantly reduced on low - density eosinophils from the hypereosinophilic syndrome . - pubmed
Cancer was found more commonly in patients with idiopathic deep vein thrombosis ( DVT ) ( 7 of 31 versus 5 of 82 patients with secondary DVT ; P = 0.012 ) , and in those patients with abnormal lactic dehydrogenase ( LDH ) levels ( 6 of 23 versus 6 of 90 ; P = 0.007 ) . - pubmed
Abnormal CEA levels allowed diagnosis of two cases of colonic cancer ( on colonoscopy ) . - pubmed
It was concluded that blood cell counts , LDH , CEA , chest radiograph , and abdominal ultrasonography ( or CT scan ) should be routinely performed on all patients with deep venous thrombosis ( particularly those with idiopathic DVT ) . - pubmed
Continuous subcutaneous insulin infusion versus injection therapy : a randomized cross - over trial under usual diabetic clinic conditions . - pubmed
Twelve C - peptide negative insulin - dependent diabetic patients participated in a randomized cross - over study of 6 months treatment with twice or thrice daily insulin injection therapy and continuous subcutaneous insulin infusion ( CSII ) . - pubmed
A novel putative mediator of insulin action which acts to inhibit adenylate cyclase and cAMP - dependent protein kinase has been purified from livers of insulin - treated streptozotocin - diabetic rats . - pubmed
[ Pyruvate kinase activity of erythrocytes in hereditary non - spherocytic hemolytic anemias ] . - pubmed
[ Adrergic beta - receptor blocking with propranolol in some disorders of cardiac rhythm ] . - pubmed
Chemotaxis of polymorphonuclear leucocytes in vivo was studied in patients with previous yersinia arthritis and in healthy subjects with or without HLA B27 by means of a skin chamber technique . - pubmed
Irrespective of previous arthritis the number of neutrophils in the chamber media was significantly higher in HLA B27 positive subjects than in those without HLA B27 . - pubmed
The present results give credence to the view that the hyperreactive neutrophils and the vasodilatory prostaglandins produced by them can together trigger a vicious circle which results in increased inflammatory symptoms in patients with yersinia arthritis who have HLA B27 as compared with those who lack this antigen . - pubmed
In this study , we investigated the presence of NTFs in cerebrospinal fluid ( CSF ) of patients with central nervous system ( CNS ) injury . - pubmed
In the 11 patients from whom consecutive CSF samples were available , NTF activity assayed in rat hippocampal cultures tended to decrease during the first several days after CNS injury . - pubmed
The hypoproliferative anemia in chronic renal failure has been assumed to be the result of decreased erythropoietin ( Ep ) production by the damaged kidney and of the shortening of erythrocyte survival . - pubmed
Hepatic catalase in rats bearing Walker tumor in the brain . - pubmed
Rats were injected with 10(5 ) cells of Walker carcinosarcoma 256 in ascites form into discrete areas of the brain ( RAS , midbrain - hypothalamus , and anterior and posterior cortex ) , and at necropsy on the sixth day postoperation the animals were sacrificed , the brains were examined for tumors , and liver homogenates were analyzed for catalase content . - pubmed
Liver catalase was little altered in rats with solid tumors in the various brain areas originating from fragments measuring 1 mm3 and harvested from donors with intramuscular Walker tumor , as was also the case with tumor - free rats submitted to hypothalamic lesioning . - pubmed
Immunohistochemical examination of the dermal collagen bundles showed a collagen pattern similar to systemic sclerosis and normal control skin . - pubmed
CONCLUSION : The sclerotic skin changes in GEMSS syndrome are the result of an abnormally increased production of normal collagen that might be attributable to the enhanced in situ production of transforming growth factor beta 1 . - pubmed
ALL-1 partial duplication in acute leukemia . - pubmed
BACKGROUND : Heavy smoking ; dyslipoproteinemias involving very low density lipoprotein ( VLDL ) , low density lipoprotein ( LDL ) and high density lipoprotein ( HDL ) ; a family history of premature coronary artery disease ; hyperinsulinemic responses to oral and intravenous glucose challenges ; and defective fibrinolytic function characterize the young postinfarction patient , but the influence of these features on the long - term prognosis is virtually unknown . - pubmed
In multivariate analysis , VLDL and global coronary atherosclerosis score predicted reinfarction ; plasma plasminogen activator inhibitor-1 ( PAI-1 ) activity and global coronary stenosis score predicted cardiac death ; and VLDL triglyceride levels , global coronary atherosclerosis score and age predicted any major coronary event . - pubmed
CONCLUSIONS : This prospective cohort study shows that hypertriglyceridemia , impaired fibrinolytic capacity secondary to plasma PAI-1 activity elevation and extensive coronary artery disease increase the risk of recurrences in men with a first myocardial infarction before age 45 and contribute to the relatively poor long - term prognosis in this patient group . - pubmed
Increased levels of the Kunitz protease inhibitor - containing beta APP mRNAs in rat brain following neurotoxic damage . - pubmed
Deposits of beta - amyloid are one of the main pathological characteristics of Alzheimer ' s disease . - pubmed
Increased levels of the KPI - containing beta APP and GFAP mRNAs were observed in tissues surrounding areas of neuronal damage . - pubmed
These results suggest that the normal ratio of beta APP isoforms may be profoundly altered as a result of neuronal damage and that non - neuronal cells may respond to neuronal injury by increased expression of the KPI - containing beta APP isoforms . - pubmed
Total lysophosphatidylcholine concentration ( sum of lysophosphatidylcholine remaining in tissue and lysophosphatidylcholine released into the buffer ) increased from 0.73 + /- 0.08 nmol / mg protein at baseline to 1.83 + /- 0.45 nmol / mg protein after 5 minutes of ischemia ( p & lt ; 0.001 ) , and was associated with evidence of cell injury ( 26 % depletion of tissue lactate dehydrogenase ) . - pubmed
Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosis . - pubmed
Cathepsin D serum mass concentrations were determined by enzyme immunoassay in patients with hepatocellular carcinoma ( n = 51 ) and/or liver cirrhosis ( n = 92 ) or benign steatosis ( n = 16 ) and correlated with some biochemical and clinical properties of these diseases . - pubmed
Interestingly , significantly higher cathepsin D serum mass concentrations ( mean + 62 % ) ( P & lt ; 0.006 ) were determined in the cirrhosis group as compared to cancer patients . - pubmed
No correlation between cathepsin D and a number of clinical and biochemical properties examined , namely , alpha - foetoprotein , number of neoplastic lesions and tumour size in cancer patients or , Child - Pugh grade of severity of cirrhosis and other enzymes of liver function tests in the cirrhotic group was found . - pubmed
The present data and those from other studies which indicate that cathepsin D may be involved in carcinogenesis suggest that this enzyme may be potentially useful as an additional biochemical marker to identify cirrhotic patients who may develop precancerous hepatic nodules . - pubmed
OBJECTIVE : The present animal study investigates the influence of an acute and almost complete isovolaemic haemodilution with a new ultrapurified polymerized bovine haemoglobin ( UPBH ) on hepatic and renal function and histology in comparison to hydroxyethylstarch ( HES ) . - pubmed
[ Characterization of the BRCA1 gene and its significance in hereditary breast cancer ] . - pubmed
Fibrates may be useful in patients with hypertriglyceridemia , and/or low HDL - cholesterol level or in the case of intolerance to statins . - pubmed
BACKGROUND : Monoclonal gammopathies - including so - called monoclonal gammopathies of undetermined significance - MGUS - may cause polyneuropathies , even if immunoglobulin concentrations are within a normal range . - pubmed
CASE REPORT : We report on a patient with a rapidly progressive polyneuropathy with severe motor disturbances in whom a small amount of a monoclonal IgM kappa cryoglobulin was found . - pubmed
CONCLUSION : This case shows that in patients with a polyneuropathy of uncertain etiology monoclonal immunoglobulins should be looked for and that a MGUS can precede a lymphoma . - pubmed
We investigated the mechanisms underlying stimulation of rapidly adapting receptors ( RARs ) during pulmonary air embolism ( PAE ) . - pubmed
Thus adenosine could not be responsible for the increase in coronary blood flow after adenosine receptor blockade and therefore is not required for norepinephrine - induced hyperemia . - pubmed
Cytokines in autoimmune disease . - pubmed
Tumor cell immunoreactivity for HMB-45 and nonreactivity for cytokeratin supported the diagnosis . - pubmed
Meta - analysis of streptokinase and heparin in deep vein thrombosis . - pubmed
The efficacy and safety of streptokinase and heparin in deep vein thrombosis ( DVT ) were compared in a meta - analysis . - pubmed
Randomized trials in which streptokinase ( followed by heparin ) and heparin alone were compared in treating phlebographically documented acute DVT were identified from MEDLINE and other sources for a meta - analysis . - pubmed
Significantly more streptokinase recipients achieved thrombolysis than recipients of heparin alone ( summary OR , 6.24 ; 95 % CI , 3.62 to 10.78 ) . - pubmed
The frequency of major bleeding was significantly higher among streptokinase recipients than recipients of heparin alone ( summary OR , 3.78 ; 95 % CI , 1.26 to 11.32 ) . - pubmed
A meta - analysis showed that , compared with heparin alone , streptokinase therapy for DVT was associated with significantly more frequent thrombolysis and major bleeding ; after exclusion of one outlying study , analysis showed that streptokinase therapy was associated less frequently than heparin alone with postthrombotic changes ( assessed by phlebographic evaluation ) and postphlebitic syndrome . - pubmed
Our data showed the CD markers expression for common ALL ( c - ALL ) were CD19+/10 + ( 100 % ) , CD20 + ( 24 % ) , CD22 + ( 100 % ) , HLA - DR+ ( 70.1 % ) , and CD34 + ( 58.8 % ) . - pubmed
CD markers expression for B - ALL were CD19 + ( 100 % ) , CD20 + ( 33.3 % ) , CD22 + ( 80 % ) , and HLA - DR+ ( 80 % ) . - pubmed
CD markers expression for T - ALL were CD3 + ( 42.9 % ) , CD5 + ( 100 % ) , CD7 + ( 85.7 % ) . - pubmed
Although the mechanisms by which LVH develops are incompletely understood , the renin - angiotensin system may play an important role . - pubmed
All major classes of antihypertensive agents ( calcium channel blockers , diuretics , beta - blockers , angiotensin - converting enzyme inhibitors ) can cause LVH regression but not all to the same degree . - pubmed
In addition , animal studies and human trials show promise for the regression of LVH with the use of angiotensin receptor blockers ( ARBs ) . - pubmed
Neuroprotective gene therapy for Huntington ' s disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF . - pubmed
Analysis of the DMBT1 gene in carcinomas of the respiratory tract . - pubmed
Therefore , we investigated DMBT1 in 25 cancer cell lines and 39 primary tumors of the respiratory tract . - pubmed
In summary , our data do not confirm previous findings reporting frequent loss of DMBT1 expression in lung cancer . - pubmed
Overexpression of lymphocytic GD3 ganglioside and presence of anti - GD3 antibodies in patients with HIV infection . - pubmed
We report here the results obtained by both ex vivo and in vitro experiments on ( 1 ) surface and cytoplasmic expression and distribution of GD3 in HIV - infected cells , ( 2 ) the presence of anti - GD3 antibodies in sera of patients with HIV infection in various stages of the disease , and ( 3 ) the association of GD3 expression with HIV - related apoptotic events . - pubmed
Interestingly , ex vivo studies of lymphocytes from patients with HIV infection also indicated that GD3 expression is strictly associated with annexin V binding , an early marker of apoptosis . - pubmed
A region - specific , modest increase in DA levels and TH - positive fiber density in the ventral - medial putamen was detected , accompanied by modest but significant decreases in parkinsonian behaviors at 5 - 6 months after grafting . - pubmed
Most cases of T - PLL express membrane T - cell receptors ( TCRs ) of the alphabeta phenotype . - pubmed
In addition experimental infection of turkey poults with APV / MN-12 resulted in detection of viral RNA in nasal turbinates and APV - specific IgG in serum . - pubmed
Cervical cat scratch disease lymphadenitis in a patient with immunoglobulin M antibodies to Toxoplasma gondii . - pubmed
Serological follow - up studies , including testing for avidity of Toxoplasma - specific immunoglobulin G antibodies , assisted in the determination of the cause of the acute lymphadenitis . - pubmed
To elucidate the relationship between changes in Ca2 + dynamics and gap junctions , we analyzed by real - time in situ Ca2 + imaging of fluo-3 loaded whole hearts the spatiotemporal occurrence of Ca2 + waves and the localization of connexin43 ( Cx43 ) at the border zone of myocardial infarcts induced in the rat by coronary ligation . - pubmed
Confocal imaging of Cx43 and actin filaments in the rat heart fixed 2 hours after coronary ligation revealed that Cx43 was markedly decreased in the area of myocyte necrosis with contraction bands and in the neighboring myocardium . - pubmed
Opportunities for studying cancer by metabolomics : preliminary observations on tumors deficient in hypoxia - inducible factor 1 . - pubmed
Neurogenic atherosclerosis mediated by neuropeptide y : hardening of the evidence . - pubmed
GENETIC CONTROL OF CELLULAR SUSCEPTIBILITY TO PSEUDOTYPES OF ROUS SARCOMA VIRUS . - pubmed
Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory . - pubmed
Neurofibrillary tangles ( NFTs ) consisting of the hyperphosphorylated microtubule - associated protein tau are a defining pathological characteristic of Alzheimer ' s disease ( AD ) . - pubmed
However , molecular mechanisms underlying overactivation of GSK-3 and its potential linkage to AD - like pathologies in vivo remain unclear . - pubmed
Here , we demonstrate that injection of wortmannin ( a specific inhibitor of phosphoinositol-3 kinase ) or GF-109203X ( a specific inhibitor of protein kinase C ) into the left ventricle of rat brains leads to overactivation of GSK-3 , hyperphosphorylation of tau at Ser 396/404/199/202 and , most significantly , impaired spatial memory . - pubmed
Significantly , specific inhibition of GSK-3 activity by LiCl prevents hyperphosphorylation of tau , and spatial memory impairment resulting from PI3 K and PKC inhibition . - pubmed
These results indicate that in vivo inhibition of phosphoinositol-3 kinase and protein kinase C results in overactivation of GSK-3 and tau hyperphosphorylation and support a direct role of GSK-3 in the formation of AD - like cognitive deficits . - pubmed
Hypoxia , the reduction of oxygen supply , results in adaptationally appropriate alterations in gene expression through the activation of hypoxia - inducible factor 1 ( HIF-1 ) to overcome any shortage of oxygen . - pubmed
Increased synthesis of HIF-1alpha may contribute to the adaptive response of increased oxygen demand under hyperthyroid conditions . - pubmed
Chromosome band 16q22 - linked familial AML : exclusion of candidate genes , and possible disease risk modification by NQO1 polymorphisms . - pubmed
Analyses of chromosomal translocation and inversion breakpoints in sporadic acute myeloid leukemias have identified many transcription factors as playing a role in leukemogenesis . - pubmed
Studies of families with a Mendelian predisposition to hematological malignancies have identified the gene coding for the transcription factor RUNX1 as a leukemia - predisposing gene involved in the first steps of leukemogenesis . - pubmed
Although CBFB forms a core - binding factor transcriptional complex with RUNX1 , previous analyses have excluded the CBFB gene as the leukemia - predisposing gene in these families . - pubmed
We demonstrated that the transcription factors E2F4 , CTCF , NFATC3 , and NFAT5 , and the genes coding for NAD ( P ) H : quinone oxido - reductase 1 ( NQO1 ) and for E - cadherin are not responsible for the leukemia susceptibility in these families . - pubmed
p38 alpha mitogen - activated protein kinase inhibition improves cardiac function and reduces myocardial damage in isoproterenol - induced acute myocardial injury in rats . - pubmed
p38 mitogen - activated protein ( MAP ) kinase is activated during ischemic / hypoxic myocardial injury . - pubmed
However , the role of activated p38 MAP kinase on cardiac function after myocardial injury is not well understood . - pubmed
In the present study , we investigated the cardioprotective effects of p38 MAP kinase inhibition in a rat model of acute myocardial injury , induced by subcutaneous injection of isoproterenol ( ISO , 20 mg / kg / d for 3 days ) . - pubmed
Cardiac function , systolic blood pressure , gene expression including collagen I and III , fibronectin and COX-2 , and the myocardial injury were analyzed . - pubmed
Data suggest that p38 alpha MAP kinase may be involved in the pathogenesis of cardiac dysfunction in ischemic myocardial injury . - pubmed
Type 1 diabetes is the result of an autoimmune attack against the insulin - producing beta cells of the endocrine pancreas . - pubmed
Current treatment for patients with type 1 diabetes typically involves a rigorous and invasive regimen of testing blood glucose levels many times a day along with subcutaneous injections of recombinant DNA - derived insulin . - pubmed
Tumor ploidy , percent 4/5 Gleason grade and pathological stage were strong predictors of outcome , while margin status and preoperative prostate specific antigen had minimal predictive strength . - pubmed
OBJECTIVE : To investigate the effects of Benefiting - bone capsule ( BBC ) on the expression of transforming growth factor - beta1 mRNA in bone tissue of the ovariectomized rats to further explain the mechanism of BBC on preventing and treating osteopoprosis . - pubmed
Ovariectomy was used to establish the osteoporotic animal model and the expression of TGF - beta1 mRNA on gene level in bone tissue was detected by real time fluorescence quantitative PCR ( FQ - PCR ) method . - pubmed
RESULTS : The expression of TGF - beta1 mRNA on gene level in bone tissue of the groups of osteoporotic animal model with BBC were all higher than that of the groups of osteoporotic animal model , which were close to the groups of sham operation . - pubmed
The increased risk of premature cardiovascular disease ( CVD ) in rheumatoid arthritis ( RA ) patients may depend on traditional risk factors but may also be attributable to RA - specific risk factors such as disease - related dyslipidemia , or cytokines such as tumor necrosis factor - alpha ( TNF - alpha ) . - pubmed
TNF - alpha may play a role in the triggering and perpetuation of atherosclerosis . - pubmed
Treatment with biologic agents directed against TNF - alpha has significant clinical benefits in inflammatory diseases such as RA and may be able to reduce cardiovascular risk . - pubmed
The disappointing results of the recent studies to antagonize TNF - alpha in CVD may have various explanations . - pubmed
However , the effects of TNF - alpha blockers on incident cases of congestive heart failure ( CHF ) in RA remains controversial . - pubmed
Due to the lack of evidence of a beneficial effect of anti - TNF - alpha agents in treatment of CHF , they should not be used to treat patients with New York Heart Association ( NYHA ) class III or IV heart failure . - pubmed
In a mouse pneumonia model the slrA knock - out D39DeltaslrA did not cause significant differences in the survival times of mice compared with the isogenic wild - type strain . - pubmed
These results suggested that SlrA is involved in colonization but does not contribute significantly to invasive pneumococcal disease . - pubmed
In cell culture infection experiments , the absence of SlrA impaired adherence to pneumococcal disease - specific epithelial and endothelial non - professional cell lines . - pubmed
In conclusion , SlrA is a functional , cyclophilin - type PPIase and contributes to pneumococcal virulence in the first stage of infection , namely , colonization of the upper airways , most likely by modulating the biological function of important virulence proteins . - pubmed
Vitamin D in chronic kidney disease : a systemic role for selective vitamin D receptor activation . - pubmed
Hyperparathyroidism occurs in most patients during the progression of chronic kidney disease ( CKD ) and one of its initiating events , reduced serum levels of 1,25 - dihydroxyvitamin D , results from a decrease in renal 1alpha hydroxylase activity , which converts 25 - hydroxyvitamin D to its activated form . - pubmed
The combination of persistently high parathyroid hormone ( PTH ) and low 1,25 - dihydroxyvitamin D is associated with bone loss , cardiovascular disease , immune suppression and increased mortality in patients with end - stage kidney failure . - pubmed
One hypothesis derived from such studies suggests that systemic activation of VDRs may have direct effects on the cardiovascular system to decrease mortality in CKD . - pubmed
Although current guidelines for regulating serum calcium , phosphate and PTH recommend specific interventions at the various stages of CKD to prevent or postpone irreversible parathyroid disease and decrease cardiovascular morbidity and mortality , emerging data suggest that vitamin D therapy may prolong survival in this patient population by mechanisms that are independent of calcium , phosphate and PTH . - pubmed
It is suggested that a re - evaluation of current treatment recommendations is needed and that future research should focus on mechanisms that distinguish potential tissue specific benefits of selective VDR activators in patients with CKD . - pubmed
On the road to discovering protective endogenous peroxisome proliferator - activator receptor - gamma ligands for endotoxemia : are we there yet ? - pubmed
Effect of liver regeneration after partial hepatectomy and ischemia - reperfusion on expression of growth factor receptors . - pubmed
AIM : To investigate the effects of experimental partial hepatectomy and normothermic ischemia - reperfusion damage on the time course of the expression of four different growth factor receptors in liver regeneration . - pubmed
The epidermal growth factor receptor , hepatic growth factor receptor , fibroblast growth factor receptor and tumour necrosis factor receptor-1 were analysed by immunohistochemistry up to 72 h after injury . - pubmed
RESULTS : In immunohistochemistry , EGFR , HGFR , FGFR and TNFR1 showed biphasic kinetics after partial hepatectomy with a peak up to 12 h , a nadir after 24 h and another weak increase up to 72 h. During liver regeneration , after ischemia and reperfusion , the receptor expression was lower ; the nadir at 24 h after reperfusion was the same . - pubmed
All patients should be screened for peritoneal fluid amylase levels in order to differentiate bacterial peritonitis from intra - abdominal pathology . - pubmed
Propofol reduces pulmonary edema by prevention of cytokine - mediated impairment of alveolar ion and fluid transport . - pubmed
Molecular characterisation of pyruvate kinase deficiency -- concerns about the description of mutant PKLR alleles . - pubmed
Here , we studied in a nude mouse model whether the expression of VEGF - A in a tumor could be imaged with a radiolabeled anti - VEGF antibody . - pubmed
The accumulation of the radiolabeled antibodies in VEGF - A expressing tumors ( LS174 T ) in nude mice was examined in biodistribution studies and by gamma camera imaging . - pubmed
Coinjection of an excess unlabeled antibody resulted in a significant decrease in radioactivity concentration in the tumor ( & lt;2.9 + /- 1.9 % ID / g , p & lt ; 0.005 ) , indicating VEGF - mediated antibody uptake . - pubmed
VEGF - A - expressing tumors could be clearly visualized on planar scintigraphic images from 24 - hr post injection onwards . - pubmed
In conclusion , VEGF - A expression in tumors can be visualized specifically with radiolabeled anti - VEGF - A - mAb . - pubmed
AXIN2 and CDH1 polymorphisms , tooth agenesis , and oral clefts . - pubmed
We investigated if AXIN2 and CDH1 polymorphisms were associated with clefts or with any associated dental subphenotypes . - pubmed
RESULTS : Comparison between cleft and control groups showed a trend for association for AXIN2 with incomplete cleft palate ( p = .006 ) and CDH1 with unilateral CL / P ( p = .03 for left CL / P and p = .04 for right CL / P ) . - pubmed
Comparison of cleft subphenotypes with tooth agenesis and controls revealed borderline associations for CDH1 ( p = .008 ) and AXIN2 ( p = .01 ) with unilateral right CL / P with tooth agenesis . - pubmed
CONCLUSIONS : We observed only borderline results for the association of AXIN2 and CDH1 with CL / P with and without tooth agenesis . - pubmed
A major focus of our research is to understand the molecular and cellular basis of X - linked lymphoproliferative disease ( XLP ) , a rare and often fatal immunodeficiency caused by mutations in the SH2D1A gene , which encodes the adaptor molecule SAP . - pubmed
Recently , we observed that SAP is essential for the development of natural killer T ( NKT ) cells , a lymphocyte population that participates in protection against certain tumors , infections , and autoimmune states . - pubmed
By using SAP as the focal point of our studies , we hope to identify novel signaling pathways that could be targeted to improve the treatment for patients with XLP as well as more common disorders , such as autoimmunity and cancer . - pubmed
Major topics focus on selected bladder cancer markers from nearly all categories of the wide field of bladder cancer markers : Hematuria , FISH , FGFR3 , SURVIVIN , u - PAR , TP53 mutation , HER-2 / neu , TPA , NMP22 , CK-19 , CK-20 , CYFRA 21 - 1 . - pubmed
Maternal CMV DNAemia remained a significant risk factor for mortality in HIV-1 - infected infants after adjusting for maternal CD4 cells / microl [ adjusted hazard ratio ( HR ) = 4.3 , confidence interval ( CI ) = 1.4 - 13 ] , CD4 % ( HR = 3.2 , CI = 1.0 - 10 ) , HIV-1 viral load ( HR = 4.1 , CI = 1.4 - 12 ) or maternal death ( HR = 3.7 , CI = 1.0 - 13 ) . - pubmed
Acromegaly : correlation between expression of somatostatin receptor subtypes and response to octreotide - lar treatment . - pubmed
This study analyzes SSTR ' s expression in somatotrophinomas , comparing to SA response , hormonal levels , and tumor volume . - pubmed
SSTR3 was more expressed in patients with tumor reduction . - pubmed
There was a positive correlation between the percentage of tumor reduction and SSTR1 , SSTR2 and SSTR3 expression . - pubmed
Our study confirmed the association between the SA response to GH and IGF - I and the SSTR2 . - pubmed
Huntington ' s disease ( HD ) is an autosomal dominantly inherited disorder , caused by an expanded polyglutamine region of a protein called huntingtin . - pubmed
Cardiac troponin I degradation in serum of patients with hypertrophic obstructive cardiomyopathy undergoing percutaneous septal ablation . - pubmed
INTRODUCTION : Troponin has become the most important marker for diagnosing acute myocardial infarction , yet knowledge is scarce regarding appearance of specific degradation fragments in the blood . - pubmed
We have recently described the appearance of intact cardiac troponin I ( cTnI ) and 7 degradation products in patients suffering from ST - elevation myocardial infarction ( STEMI ) using Western blot analysis . - pubmed
Here the iatrogenic induction of myocardial necrosis occurs in vivo , allowing us to investigate degradation of cTnI by the second . - pubmed
Western blot analysis was performed with subsequent analysis of relative intensities of the bands as compared to the degradation of cTnI in STEMI patients from the ASSENT-2 troponin substudy . - pubmed
Their early rise in intensity , occurring within few minutes after the alcohol injection , emphasizes how susceptible troponin bands are to chemical / ischemic insults . - pubmed
CONCLUSION : This work describes the degradation products of troponin I in HOCM patients undergoing PTSMA . - pubmed
Hodgkin ' s lymphoma : the role of cell surface receptors in regulation of tumor cell fate . - pubmed
Despite the loss of BCR - the master - regulator of B cell fate , HRS cells express a number of receptors that regulate tumor cell survival . - pubmed
Due to the mutations in genes encoding proteins of CD95 - mediated apoptotic signaling pathway , it is not functional in HRS cells . - pubmed
Ligands of TNF family receptors on cells in HL microenvironment contribute to the activation of canonical and non - canonical NF - kappaB signaling pathways and survival program of HRS cells . - pubmed
Moreover , in HRS cells a number of multiple mutations in negative NF - kappaB regulators , and also gains and amplifications of positive regulators , cooperate in deregulating these pathways . - pubmed
CONCLUSION : The review presents the current views on the role of cell surface receptors in maintenance of HL microenvironment favorable for HRS cells survival . - pubmed
Immunization of knock - out alpha / beta interferon receptor mice against lethal bluetongue infection with a BoHV-4 - based vector expressing BTV-8 VP2 antigen . - pubmed
IFNAR(-/- ) mice intraperitoneally inoculated twice with BoHV-4 - A - IgK - VP2gDtm at different time points developed serum neutralizing antibodies against BTV and showed a strongly reduced viremia and a longer survival time when challenged with a lethal dose of BTV-8 . - pubmed
Specific GATA inhibitors have recently been developed as novel drugs for the management of anemia . - pubmed
The results showed that the expression of fetuin - B in mice plasma was increased by K-11706 , but not by recombinant human erythropoietin or hypoxia . - pubmed
Tight glucose control ( TGC ) using a sliding scale based on intermittent blood glucose measurements occasionally can have a fatal outcome as a result of insulin - induced hypoglycemia . - pubmed
The serum levels of S100A12 and HMGB-1 tended to decrease , and those of sRAGE tended to increase , in the TGC group . - pubmed
This study was performed to assess the efficacy of intradermal avotermin ( TGF - beta3 ) for the improvement of scar appearance following scar revision surgery . - pubmed
Laser - capture microdissection for Factor VIII - expressing endothelial cells in cancer tissues . - pubmed
Reportedly , CD300f negatively regulates interactions between dendritic and T cells and acts as an anti - inflammatory molecule in a multiple sclerosis mouse model . - pubmed
The percentage of apoptotic cells in distal tubules found was : 3.02 % ( 1.03 - 5.00 % ) in IGF , 1.66 % ( 0.92 - 2.39 % ) in SGF , and 1.76 % ( 0.84 - 2.68 % ) in DGF ; these differences were not significant . - pubmed
Tissue - type plasminogen activator ( t - PA ) can modulate permeability of the neurovascular unit and exacerbate injury in ischemic stroke . - pubmed
SNP induced nephrotoxicity by increasing serum creatinine and blood urea nitrogen , SNP significantly decreased malate dehydrogenase , glucose-6 - phosphatase , fructose-1,6 - bisphosphatase and malic enzyme but increased lactate dehydrogenase and glucose-6 - phosphate dehydrogenase . - pubmed
The activity of catalase and glutathione peroxidase decreased concomitantly with increased lipid peroxidation , indicating that the significant kidney damage has been inflicted by SNP . - pubmed
Over the past two decades , heat shock proteins ( HSPs ) have been implicated in inflammatory responses and autoimmunity . - pubmed
The immunoglobulin heavy - chain binding protein ( Bip)/glucose - regulated protein 78 ( GRP78 ) , calnexin , calreticulin , glucose - regulated protein 94 ( GRP94)/gp96 , oxygen regulated protein 150 ( ORP150)/glucose - regulated protein 170 ( GRP170 ) , homocysteine - induced ER protein ( Herp ) and heat shock protein 47 ( hsp47)/Serpin H1 , which are expressed not only in the ER but also occasionally at the cell surface play pathophysiological roles in autoimmune and inflammatory diseases as pro- or anti - inflammatory factors . - pubmed
There was a significant increase in 3 - CT levels in both brain regions ( P<0.01 ) , whereas aconitase activity was significantly decreased in autism cerebellum ( P<0.01 ) , and was negatively correlated with GSH / GSSG ( P=0.01 ) . - pubmed
Correlation between IL-7 and MCP-1 in diabetic chronic non healing ulcer patients at higher risk of coronary artery disease . - pubmed
Cytokines play an extremely important role in the pathogenesis of coronary artery disease ( CAD ) in which interleukin ( IL )- 7 is a major regulator of T - cell homeostasis which is conced in the stimulation of leukocyte - endothelial cell adhesion during inflammatory events . - pubmed
Circulating IL-7 is associated with activation of monocyte and natural killer cells , leading to enhanced production of inflammatory cytokines and chemokines observed in atherosclerosis and acute coronary syndromes . - pubmed
In conclusion the positive correlation between plasma concentration of IL-7 , MCP-1 and hs - CRP in diabetic foot patients observed herein , suggests a plausible role for IL-7 in the promotion of clinical instability in coronary artery disease . - pubmed
Together they define a segmental progeroid phenotype of the Ercc1(-/Delta7 ) mouse model . - pubmed
Although mastermind - like domain containing 1 ( MAMLD1 ) ( CXORF6 ) on human chromosome Xq28 has been shown to be a causative gene for 46,XY disorders of sex development with hypospadias , the biological function of MAMLD1 / Mamld1 remains to be elucidated . - pubmed
Disappearance of Serum Methylated p16 Indicates Longer Survival in Patients with Gastric Cancer . - pubmed
PURPOSE : The aim of this study was to assess clinical correlations with postoperative alteration of p16 DNA methylation , and to clarify whether postoperative changes in the serum DNA methylation status of p16 could be used as a reliable prognostic factor for gastric cancer . - pubmed
Whereas methylation of preoperative serum DNA was not correlated with survival , patients with postoperative disappearance of p16 methylation showed longer survival than those without postoperative disappearance of p16 methylation in the patients who had gastric cancer with lymph node metastasis ( P=0.042 ) . - pubmed
CONCLUSIONS : Postoperative disappearance of p16 methylation could be an available prognostic factor for node - positive gastric cancer . - pubmed
Units were assessed for hemolysis , adenosine triphosphate ( ATP ) concentration , lipid composition , and RMP generation , as well as PS and CD47 expression throughout 49 days of HS . - pubmed
Accumulation of FGF9 in prostate cancer correlates with epithelial - to - mesenchymal transition and induction of VEGF - A expression . - pubmed
AIM : The aim of the present study was to investigate the molecular mechanism of fibroblast growth factor ( FGF )- 9 in prostate cancer cells . - pubmed
CONCLUSION : FGF9 can be associated with epithelial - to - mesenchymal transition and invasion by inducing VEGF - A expression in prostate cancer cells . - pubmed
Comment on ' Strong reduction of AGO2 expression in melanoma and cellular consequences ' . - pubmed
Of the 29 tumors that were diagnosed as glioblastoma multiforme ( GBM ) , 11 had an OD component of which four showed codeletions of 1p and 19q ( 36.4 % ) and two tumors showed epidermal growth factor receptor ( EGFR ) amplification ( 20 % ) without 1p19q codeletions . - pubmed
Amongst the remaining 18 GBMs without an OD component , three cases showed EGFR amplification ( 16.7 % ) , one case showed isolated deletion of 1p and none showed 1p19q codeletions . - pubmed
METHODS : This case study examined the effect of a 12 - week exercise and manual therapy intervention on morphology , pain , cardiopulmonary fitness , strength , neurological balance , immune markers ( CD4 cell count ) , and quality of life in a 43 - year - old woman living with HIV . - pubmed
The treatments analysed were : antihypertensive treatments , statins , antiplatelet drugs , xanthine oxidase inhibitors , correction of metabolic acidosis , treatment with ( calcium or non - calcium ) phosphate binders , vitamin D ( calcitriol or paricalcitol ) , erythropoietin and the availability of an internal arteriovenous fistula ( IAVF ) . - pubmed
In the multivariate models , we observed that , in addition to age , the comorbidity index , serum albumin , pre - dialysis treatment with angiotensin - converting - enzyme inhibitors and/or angiotensin receptor blockers , correction of acidosis with sodium bicarbonate and IAVF at the start of haemodialysis were significantly associated with better survival in dialysis . - pubmed
Recently , naturally occurring genetic variants in both beta2 integrins and ICAMs are reported to be associated with autoimmune disease . - pubmed
Finally , toxin - driven IL-1beta release supports the hypothesis that this cytokine axis is a likely target for therapeutic intervention for C. - pubmed
BACKGROUND AND OBJECTIVES : Pegylated interferon ( peg - IFN )- alpha2a and - alpha2b show different pharmacokinetic properties but are used interchangeably for hepatitis C treatment in traditional dual combinations and with newer agents . - pubmed
METHODS : Chronic hepatitis C patients treated with ribavirin combined with peg - IFN - alpha2a ( N = 109 ) or -alpha2b ( N = 114 ) were studied . - pubmed
RESULTS : Viraemia decline after 48/72 h and 7 days was significantly greater with peg - IFN - alpha2b ( 1.96 and 2.12 vs 1.49 and 1.20 log10 IU / mL with peg - IFN - alpha2a ; p & lt ; 0.001 ) . - pubmed
Differences were of larger extent in patients with advanced fibrosis ( p = 0.002 ) , genotype 1 infection ( p = 0.002 ) and CT / TT genotypes of IL28B ( p = 0.001 ) . - pubmed
CONCLUSION : There are significant pharmacodynamic differences between peg - IFN - alpha2a and - alpha2b in the early phase of chronic hepatitis C treatment . - pubmed
The proportion of patients who died from cancer was the highest in the calcium channel blocker ( CCB ) group ( 6.5 % ) , followed by thiazide diuretics ( 4.4 % ) , angiotensin converting enzyme inhibitors ( 4.2 % ) and beta - blockers ( 2.6 % ) . - pubmed
BACKGROUND : Hypersensitivity reactions to anaesthetic agents are rare but often severe , with a mortality ranging from 4 to 9 % in IgE - mediated events . - pubmed
Severe reactions were associated with older age ( p = 0.025 ) , asthma ( p = 0.042 ) , history of hypertension ( p = 0.001 ) , intake of serum angiotensin converting enzyme inhibitor medication ( p = 0.012 ) or serum angiotensin II antagonist ( p = 0.033 ) , higher levels of basal tryptase ( p = 0.0211 ) . - pubmed
Cardiovascular symptoms ( p = 0.006 ) and history of hypersensitivity to antibiotics ( p = 0.029 ) were more frequently reported in IgE - mediated reactions . - pubmed
Our study therefore aimed to analyze the clinical manifestations and patterns of cerebral atrophy , amyloid beta deposition and regional glucose metabolism in Chinese PCA patients , comparing them directly with those of typical Alzheimer ' s disease ( TAD ) . - pubmed
Population - weighted , logistic models estimated how strongly each anthropometric indicator was associated with 5 cardiometabolic disorders : Dysglycemia ( glycated hemoglobin & gt;=5.7 % ) , HyperNonHDLc ( non - high - density - lipoprotein [ HDL ] cholesterol & gt;=4.14 mmol / L , or taking anticholesteremic medications ) , Hypertension ( systolic blood pressure & gt;=140 mm Hg or diastolic blood pressure & gt;=90 mm Hg , or taking antihypertensive medications ) , HyperALT ( alanine transaminase & gt;=p75 [ 75th percentile , sex - specific ] ) , and HyperGGT ( gamma - glutamyltransferase & gt;=p75 [ sex - specific ] ) . - pubmed
Included are a review of the potential applications of IgY in the control of enteric infections of either bacterial or viral origin such as enterotoxigenic Escherichia coli , Salmonella spp . - pubmed
Sex - specific troponin measures for diagnosis of acute coronary syndrome . - pubmed
Gut Microbial Membership Modulates CD4 T Cell Reconstitution and Function after Sepsis . - pubmed
Toxascaris leonina galectin ( Tl - gal ) is a galectin-9 homologue protein isolated from an adult worm of the canine gastrointestinal nematode parasite , and Tl - gal - vaccinated challenge can inhibit inflammation in inflammatory bowel disease - induced mice . - pubmed
RESULTS : Our analysis revealed the lack of clinically relevant interactions between preparations of levodopa and benserazide ( used for the treatment of PD ) and angiotensin - converting enzyme inhibitors , antagonists of AT1 receptor for angiotensin II or antagonists of beta - adrenoreceptors ( beta - adrenolytics ) . - pubmed
The anti - convulsive effects of the natural product quinine may - at least in part - be explained by interaction with SV2A. - pubmed
The role of antithrombin in patients with toxic epidermal necrolysis . - pubmed
BACKGROUND : Prostate - specific membrane antigen positron emission tomography / computed tomography ( PSMAPET / CT ) is a new and evolving diagnostic method in prostate cancer with special impact on treatment planning in image - guided radiotherapy ( IGRT ) . - pubmed
CONCLUSIONS : Preliminary results of this study show high metabolic response rates of PSMA PET - positive metastatic lesions after hypofractionated radiotherapy in follow - up PSMA PET with promising local control rates . - pubmed
PURPOSE : The aims of this study were to develop a population pharmacokinetic ( PPK ) model of lamotrigine ( LTG ) in Chinese epileptic children by using nonlinear mixed effects modeling ( NONMEM ) and to investigate the effects of valproic acid ( VPA ) and genetic polymorphisms of the major metabolizing enzymes ( UGT1A4 , UGT2B7 ) on the pharmacokinetics of LTG . - pubmed
The expressions of the leaf - abundant isoforms , HbMT2 and - 3L were up - regulated following pathogenic fungus infection and high - temperature stress , but down - regulated by low - temperature stress . - pubmed
The BRCA1 - PALB2 - BRCA2 axis plays an essential role in DNA homologous recombination repair , defect in which drives genome instability and cancer development . - pubmed
Following ionizing radiation , the mutant mice displayed higher levels of DNA breaks and stronger induction of p53 and p21 , but continued DNA synthesis , reduced apoptosis , and accelerated tumor development . - pubmed
The differences in p21 induction , DNA synthesis , and apoptosis between wild - type and mutant mice were substantially more pronounced in the mammary gland than in the intestine , suggesting a potential contributing factor to the increased risk and the tissue specificity of BRCA / PALB2 - associated tumor development . - pubmed
Treatment of the mutant mice with an inhibitor of NF - kappaB reactivated apoptosis and delayed tumor development following radiation . - pubmed
YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity . - pubmed
The Hippo pathway effector , Yes - associated protein ( YAP ) , is a transcriptional coactivator implicated in cholangiocarcinoma ( CCA ) pathogenesis . - pubmed
The importance of LCK in CCA biology was demonstrated by clinical observations suggesting LCK expression levels were associated with early tumor recurrence following resection of CCA . - pubmed
The hsa_circ_0044235 in peripheral blood from RA patients did not correlate with C - reactive protein ( CRP ) , erythrocyte sedimentation rate ( ESR ) , rheumatoid factor ( RF ) , anti - citrullinated protein antibodies ( ACPA ) or disease activity score 28 ( DAS28 ) . - pubmed
, c.416T>C ( p. Phe139Ser ) in SORD , c.1048_1049delGCinsCG ( p. Ala350Arg ) in KRT6A , c.1159G>T ( p. Gly387Cys ) in SVEP1 , and c.430G>C ( p. Gly144Arg ) in MRPL38 as a critical genetic factor for liver cancer . - pubmed
Advanced Yeast Models of Familial Alzheimer Disease Expressing FAD - Linked Presenilin to Screen Mutations and gamma - Secretase Modulators . - pubmed
APP is cleaved by gamma - secretase to produce amyloid beta peptide ( Abeta ) , which is deposited in the brains of Alzheimer disease patients . - pubmed
By studying the loss - of - function properties of PS1 mutants , it is possible to successfully screen FAD suppressor mutations and identify gamma - secretase modulators ( GSMs ) , which are promising Alzheimer disease therapeutic agents . - pubmed
Morphine , which acts through opioid receptors , is one of the most efficient analgesics for the alleviation of severe pain . - pubmed
Regulatory T cell is critical for interleukin-33 - mediated neuroprotection against stroke . - pubmed
Interleukin-33 ( IL-33 ) is known to activate the regulatory T lymphocytes ( Tregs ) , which are negatively correlated with brain damage after ischemic stroke . - pubmed
In vivo , male C57BL / 6 N mice were subjected to 60 min of transient middle cerebral artery occlusion ( tMCAO ) , followed by daily administration of vehicle or IL-33 immediately after injury . - pubmed
Behavioral changes , brain edema , neuronal injury , Treg percentages , and cytokine expression levels were investigated in each group . - pubmed
The results indicate that intraperitoneal administration of anti - CD25Ab reduced CD4 + CD25 + Foxp3 + Tregs , increased infarct volume , enhanced stroke - induced cell death , and decreased sensorimotor functions . - pubmed
Overall , these findings showed that IL-33 afforded neuroprotection against ischemic brain injury by enhancing ST2 - dependent regulatory T - cell expansion and activation via a mechanism involving anti - apoptosis proteins and cytokines , representing a promising immune modulatory target for the treatment of stroke . - pubmed
The evaluation of Ptk7 transcripts in the thymus , for its part , showed a decrease in expression , especially following an infection at day 10 of gestation , which supports the hypothesis of T cell accumulation in a mature stage in the thymus . - pubmed
PAX 8 - positive sarcomatoid carcinoma arising from the liver with aggressive phenotype : An autopsy case . - pubmed
Accordingly , the ongoing medical examinations and the autopsy reports of the deceased individuals indicate that organs / tissues with high expression levels of ACE2 , TMPRSS2 and other putative viral entry - associated genes are most vulnerable to the infection . - pubmed
Furthermore , expression , structural and docking analyses of ACE2 revealed the potential risk of olfactory dysfunction in four additional mammalian species , revealing an evolutionarily conserved infection susceptibility . - pubmed
Epidermal Growth Factor Receptor and its Oncogenic EGFRvIII Variant in Benign and Malignant Brain Tumors . - pubmed
BACKGROUND / AIM : Tumorigenesis and cancer progression might be driven by abnormal activation of growth factor receptors . - pubmed
Importantly , molecular changes in EGFR - dependent signaling is one of the most common characteristics of brain tumors . - pubmed
PATIENTS AND METHODS : HER1 and EGFRvIII variants in meningiomas and glioblastomas were evaluated at the RNA level . - pubmed
RESULTS : EGFRvIII was found in 18.6 % of glioblastomas ( GBM ) , whereas 25 % of EGFRvIII positive tumors express wild - type EGFR as well . - pubmed
HER1 was over - expressed in benign meningiomas compared to glioblastomas , whereas HER1 expression in meningiomas differed significantly between sub - types of meningiomas . - pubmed
EGFRvIII and HER1 where positively correlated in glioblastomas . - pubmed
Yet , the patient overall survival did not differ between high- and low - HER1 expressing glioblastomas or between EGFRvIII positive and negative GBMs . - pubmed
CONCLUSION : HER1 may be considered as an independent factor for classification of benign meningiomas . - pubmed
The mRNA levels of HER1 or EGFRvIII should not be used as independent prognostic factors for patients with gliomas . - pubmed
Hormone receptors in breast cancer and response to chemotherapy . - pubmed
Serum immunoglobulins in patients with schistosomiasis mansoni . - pubmed
The authors evaluated immunglobulins IgA , IgC and IgM in two groups of schistosomiasis patients , 20 presenting the hepato - intestinal form ( HI ) and 20 the hepatosplenic form ( HS ) . - pubmed
Hyperparathyroidism developed in 13 of 15 patients with serum parathormone levels greater than 500 but in only six of 56 patients with values less than 500 . - pubmed
Progressive bone disease and elevated serum parathormone levels are the most important indicators . - pubmed
Our data suggest that indoleamine-2,3 - dioxygenase ( IDO ) , the rate limiting enzyme of the kynurenine pathway of L - tryptophan metabolism , was activated in both syndromes by cytokines including IFN - gamma , and that perhaps products of tryptophan metabolism played a role in the pathogenesis of EMS and TOS . - pubmed
[ Clinical significance of serum ferritin and acute phase reactant proteins levels in patients with cervical cancer ] . - pubmed
Serum ferritin ( SF ) levels from 162 patients with cervical cancer and their serum alpha 1 - acid glycoprotein ( alpha 1 - AGP ) . - pubmed
The result showed that concentration of SF , alpha 1 - AGP , alpha 1 - AT were significantly higher , while TF significantly lower in cervical carcinoma patients during active period than from patients with benign tumors and normal persons . - pubmed
The positive rate of SF , alpha 1 - AGP and Tf in cervical cancer patients during active period was significantly higher than that of alpha 1 - AT . - pubmed
All had chronic hepatitis , on biopsy , and were positive for HBcAg on hepatocytes . - pubmed
A second liver biopsy was available in 15 patients , and HBcAg was negative in all ; histology was normal in eight , unchanged in one , and compatible with cirrhosis in six . - pubmed
The same IgE- and IgG - rich fractions induced eosinophil - mediated cytotoxicity of live schistosomula in vitro . - pubmed
The proportions of alpha 1AT to ALP vary in patients with alpha 1AT deficiency ( 1:9 ) , established emphysema ( 1:1 ) and subjects with healthy lungs ( 10:1 ) . - pubmed
The hyperthermia elicited by a subcutaneous ( sc ) injection of 8 mg / kg morphine to freely moving rats was not diminished by CCK pretreatment . - pubmed
CCK ( 5 micrograms / kp ip ) completely prevented the restraint stress - induced hyperthermia . - pubmed
The role of complement and protease systems in development of tissue injury are also discussed . - pubmed
FVIII RAg and FVIII Rcof were both significantly elevated in diabetes mellitus . - pubmed
The FVIII RAg release ( delta FVIII RAg ) was significantly less in the diabetics . - pubmed
Fibrinolytic activity , FVIII RAg and FVIII Rcof are independent of the degree of metabolic control in patients with diabetes . - pubmed
[ Cyclic elevation of HbF in a case of Blackfan - Diamond disease . - pubmed
Preoiperative carcinoembryonic antigen level and prognosis in colorectal cancer . - pubmed
Carcinoembryonic antigen ( CEA ) levels were estimated in 117 patients before resection of colorectal cancer . - pubmed
CEA values rose progressively with tumour stages , and were higher in patients with liver metastases compared with patients with only lymph - node spread . - pubmed
A single preoperative CEA estimation does not add to the prognostic information available from careful assessment of the stage of tumour spread . - pubmed
Measurement of chromosomal aberrations , sister chromatid exchange , hprt mutations , and DNA adducts in peripheral lymphocytes of human populations at increased risk for cancer . - pubmed
Sister chromatid exchanges ( SCE ) and polycyclic aromatic hydrocarbon ( PAH)-DNA adducts were evaluated in a group of firefighters ; chromosomal aberrations and hprt mutations were evaluated in a group of cancer patients undergoing radioimmunoglobulin therapy ( RIT ) ; SCE and acrolein - modified DNA were measured in cancer chemotherapy patients and in pharmacists preparing chemotherapy prescriptions ; and SCE and PAH - DNA adducts are being measured in U.S. army troops stationed in Kuwait . - pubmed
Familial hypobetalipoproteinemia represents a heterogeneous group of genetic defects in which the concentrations of plasma apolipoprotein B and apo - B - containing lipoproteins VLDL and LDL are abnormally low . - pubmed
In one family , heterozygotes had very low apo B levels and their major HDL subfraction was HDL2 as in abetalipoproteinemia , whereas in the second family heterozygotes had apo B levels approximately half on normal and the major HDL subfraction was HDL3 with an HDL elution pattern intermediate between that observed in abetalipoproteinemia and normal subjects . - pubmed
Cytoplasmic markers of potential malignancy have been examined and , of these , keratins , filaggrin , and some carcinoma antigens show most promise . - pubmed
Low expression of the Lsp1 gene in early mouse T - lymphomas induced by N - methyl - N - nitrosourea . - pubmed
To determine whether the down - regulation of LSP1 expression is an early event which occurs in vivo in the tumor , rather than as a consequence of in vitro propagation of T - lymphoma cells , we analyzed LSP1 expression in primary T - lymphomas induced in AKR / J or AKR / J x BALB / cJ mice by a single intraperitoneal ( i.p . ) - pubmed
Two- color Fluorescence Activated Cell Sorter ( FACS ) analysis showed that all tumors had an immature CD4+/CD8 + double positive ( DP ) phenotype . - pubmed
Since these cells may be infiltrating lymphocytes which can be expected to express the Lsp1 gene at a high level these tumors were not included in our analysis . - pubmed
Nineteen tumors were analyzed for Lsp1 gene expression and 13 contained reduced levels of LSP1 RNA , ranging from 4 % to 44 % of those found in age - matched normal thymus . - pubmed
Six tumors showed either no or only a small reduction in LSP1 RNA . - pubmed
These tumors had developed later than those expressing low levels of LSP1 . - pubmed
The level of LSP1 RNA in tumors developing & lt;110 days after injection of MNU was 19.1 % + /- 5.2 ( mean + /- SEM ) , while the level of LSP1 in later tumors was 78.4 % + /- 13.0 ( P = 0.004 ) . - pubmed
Second , they show that down - regulation of the Lsp1 gene in transformed T - cells is not the result of prolonged in vitro culture , but occurs in the majority of primary tumors . - pubmed
Third , they show that there are two classes of T - lymphoma , which differ in their expression of LSP1 RNA and that the down - regulation of LSP1 is specifically associated with the early appearance of T - lymphoma after injection with MNU . - pubmed
In man , iNOS immunoreactivity was also primarily localized in macrophages on the seventh day following death from myocardial infarction . - pubmed
Inhibitory H3 receptors on sympathetic nerves of the pithed rat : activation by endogenous histamine and operation in spontaneously hypertensive rats . - pubmed
Two H3 receptor agonists , R -(-)- alpha - methylhistamine and imetit , inhibited the electrically induced increase in diastolic blood pressure in a dose - dependent manner . - pubmed
Moreover , it demonstrates that these H3 receptors are probably activated by endogenous histamine and appear to be operative in hypertension . - pubmed
Results also suggested that AIDS patients base treatment decisions primarily on the likelihood of raising CD4 + cell counts and restrictiveness of dosing regimens , but are not influenced by FDA approval status , volume of empirical support for the medications , or even possible harmful side effects . - pubmed
Such metabolic anomaly would be responsible for the alterations in both the skin barrier function and in the Th2 inflammatory reactions in part mediated through IgE. - pubmed
Genetic heterogeneity of the 5 ' uncoding region of the catalase gene in Hungarian acatalasemic and hypocatalasemic subjects . - pubmed
None of these mutations may be the causal mutation(s ) of acatalasemia as each of these nucleotide substitutions were detected in healthy subjects with normal blood catalase activity . - pubmed
BACKGROUND : This study evaluates whether a new analytic principle , processing - independent analysis ( PIA ) , offers better specificity and sensitivity than the conventional gastrin radioimmunoassay in the diagnosis of gastrinomas . - pubmed
METHODS : Plasma concentrations of alpha - amidated gastrins and the total progastrin product were measured with radioimmunoassay and with PIA , respectively , in 512 samples taken for gastrin measurement and in a selected group of gastrinoma patients ( n=10 ) . - pubmed
CONCLUSIONS : In screening for gastrinomas PIA offered no diagnostic advantages in comparison with conventional gastrin radioimmunoassay . - pubmed
However , in selected patients who in spite of normal or slightly increased concentrations of amidated gastrins were still suspected of having gastrinoma , additional measurement of the total progastrin product showed incomplete processing of progastrin and thus proved helpful in establishing the diagnosis . - pubmed
In this study , the effect of the angiotensin - converting - enzyme inhibitor ( ACE inhibitor ) Ramipril ( 5 mg / day ) and calcium antagonist Isradipin ( 5 mg / day ) treatment of two groups of hypertensive patients ( n = 22 in each of group ) was evaluated . - pubmed
In conclusion , ACE inhibition with Ramipril and calcium channel blocking with Isradipin lead to a moderate improvement of blood rheology in patients with hypertension . - pubmed
These data suggest that immunological differences , depending on cytokine gene polymorphisms , regulate the resistance to EBV infection . - pubmed
, cyclin B1 , cyclin D1 , cdk4 , and PCNA , in rat brain after transient MCA occlusion , and compared the temporal profile of the results with that of TUNEL study , which detects double strand breaks in DNA . - pubmed
There were no immunoreactivities for cyclin B1 , cyclin D1 , and PCNA in the brain with and without ischemia . - pubmed
As for cdk4 , however , it became present at 1 and 3 days of reperfusion after 2 h of ischemia . - pubmed
These results indicate that aberrant expression of cdk4 , but not cyclin B1 , cyclin D1 or PCNA , actually takes place in the brain after MCA occlusion , but this is not the causative mechanism of apoptotic cell death in the brain with ischemia . - pubmed
Combined highly active anti - retroviral therapy ( HAART ) with protease and reverse transcriptase inhibitors has modified the natural history of opportunistic infections and neoplasms in human immunodeficiency virus ( HIV )- infected patients . - pubmed
The ELISAs based on the rNP50s of HTNV , SEOV , and DOBV successfully differentiated three groups of patient sera , previously defined by neutralization tests : 17 with HTNV infection , 12 with SEOV infection , and 20 with DOBV infection . - pubmed
The entire rNP of Puumala virus ( PUUV ) distinguished PUUV infection from the other types of hantavirus infection . - pubmed
HIV-1 infection induces alteration of cellular lipids : ( 1 ) shift in phospholipid synthesis to neutral lipids associated with the viral load , polyunsaturated fatty acid ( PUFA ) peroxidation , and n-3 deficiency with deregulation of cytokines and PPAR - gamma ( peroxisome proliferator - activated receptor - gamma ) , and ( 2 ) alloimmune phospholipid antibody production in which antibodies to cardiolipin and to phosphatidylserine are most prevalent , due to the destruction of mitochondrial membranes and progression of lymphocyte apoptosis . - pubmed
LD syndrome appears to be induced by PIs that inhibit GLUT4 , glucose transporter isoform , and by NRTIs which provoke mitochondrial failure . - pubmed
RESULTS : The median level of urinary iodide of the sample subjects was 614.61 micrograms / L. The prevalence of clinical and subclinical hyperthyroidism was 1.21 % and 1.12 % respectively ; 92.3 % of the clinical hyperthyroidism were of Graves ' disease and 75 % of the subjects with subclinical hypothyroidism were TRAb positive . - pubmed
The ErbB receptor family : a therapeutic target for cancer . - pubmed
This article reviews the current state of efforts targeting the ErbB family of tyrosine kinase receptors in cancer therapy . - pubmed
Influence of the endothelial nitric oxide synthase polymorphism on the progression of autosomal dominant polycystic kidney disease and IgA nephropathy . - pubmed
Our study tried to verify the hypothesis that endothelial nitric oxide synthase ( ecNOS ) gene polymorphisms in intron 4 could have some relevance to the progression of ADPKD and/or IgA nephropathy . - pubmed
The frequencies of ecNOSa / b + a / a and ecNOSb / b genotypes in ADPKD patients were : 26.6 % ( 8/30 ) and 73.4 % ( 22/30 ) in ADPKD patients with normal renal function , 30 % ( 9/30 ) and 70 % ( 21/30 ) in ADPKD with ESRF , 35.2 % ( 18/51 ) and 64.8 % ( 33/51 ) in young ADPKD patients , 60 % ( 12/20 ) and 40 % ( 8/20 ) in ADPKD patients with ESRF later than in 62 years . - pubmed
In IGAN , the frequencies of ecNOSa / b + a / a and ecNOSb / b genotypes were 24 % ( 12/50 ) and 76 % ( 38/50 ) in IgA with normal renal function and 20.9 % ( 9/43 ) and 79.1 % ( 38/43 ) in IgA with ESRF . - pubmed
CONCLUSION : Both in ADPKD and IGAN groups , there was no significant difference in the frequencies of ecNOS genotypes between patients with normal renal function and age matched patients with ESRF and between patients with normal renal function and control group . - pubmed
The frequency of ecNOSa allele was significantly higher in a number limited group ADPKD patients with ESRF later than in 62 years ( Chi - square test p & lt ; 0.05 ) . - pubmed
However after 12 weeks treatment in participants with moderate to severe lung disease compared to DNase , HS 5mls twice a day showed less benefit to FEV1 , WMD -13.00 ( 95%CI -22.46 to -3.54 ) . - pubmed
Apolipoprotein E epsilon4 allele , AD pathology , and the clinical expression of Alzheimer ' s disease . - pubmed
OBJECTIVE : To test the hypothesis that the APOE epsilon4 allele is associated with the clinical manifestations of AD through an association with the pathologic hallmarks of disease . - pubmed
CONCLUSIONS : The APOE epsilon4 allele appears to be associated with the clinical manifestations of AD through an association with the pathologic hallmarks of AD rather than another mechanism . - pubmed
Support for this hypothesis comes from studies in adenosine - deaminase - deficient mice where lung adenosine levels accumulate in association with increased lung inflammation and damage . - pubmed
Furthermore , lowering adenosine levels or antagonizing adenosine receptors can reverse pulmonary phenotypes in this model , suggesting that chronic adenosine elevations can affect signaling pathways that mediate aspects of chronic lung disease . - pubmed
These data provide further evidence that environmental pollutants can influence allergic inflammation through enhanced Fc epsilon RI - coupled mediator release from human basophils . - pubmed
The immunopathogenesis of demyelination in multiple sclerosis involves an autoantibody response to myelin oligodendrocyte glycoprotein ( MOG ) , a type I transmembrane protein located at the surface of CNS myelin . - pubmed
Most VPM - projecting neurons examined did not show Fos - like immunoreactivity after masseter inflammation . - pubmed
Serum amyloid A , C - reactive protein and remnant - like lipoprotein particle cholesterol in type 2 diabetic patients with coronary heart disease . - pubmed
BACKGROUND : Serum amyloid A ( SAA ) and C - reactive protein ( CRP ) have been suggested to be involved in the process of coronary heart disease ( CHD ) and to be potential markers and/or predictors of CHD . - pubmed
Remnant - like lipoprotein particles ( RLPs ) , which are regarded as atherogenic remnant lipoprotein , are reported to be increased in type 2 diabetic patients . - pubmed
We assessed the association of CHD with SAA , CRP and RLP - cholesterol in type 2 diabetic patients . - pubmed
RESULTS : The mean standard deviation values of RLP - cholesterol in patients with and without CHD were 0.22 ( 0.26 ) mmol / L and 0.15 ( 0.10 ) mmol / L , respectively ( P & lt;0.05 ) . - pubmed
Median ( interquartile ranges ) for SAA in patients with and without CHD were 7.4 ( 4.2 - 11.2 ) mg / L and 3.9 ( 2.2 - 5.9 ) mg / L , respectively ( P & lt;0.001 ) . - pubmed
Median ( interquartile ranges ) for CRP in patients with and without CHD was 1.14 ( 0.45 - 2.08 ) mg / L and 0.43 ( 0.19 - 1.25 ) mg / L , respectively ( P & lt;0.001 ) . - pubmed
CONCLUSION : These data suggest that SAA , CRP and RLP - cholesterol are increased in type 2 diabetic patients with CHD , and that the inflammatory proteins correlate with remnant lipoprotein . - pubmed
We observed these patients for 28.5 + /- 12.8 ( mean + /- SD ; range 12 - 53 ) months after transient thyrotoxicosis , and measured TSH , FT4 , and TSH binding inhibitor immunoglobulin in sera . - pubmed
Life - threatening adverse reaction followed by thrombocytopenia after passive transfusion of fresh frozen plasma containing anti - CD36 ( Nak ) isoantibody . - pubmed
BACKGROUND : Anti - CD36 isoantibody in blood recipients is reported to cause refractoriness to platelet ( PLT ) transfusions and posttransfusion purpura - like syndrome . - pubmed
CONCLUSION : This is the first reported case of life - threatening adverse effects and thrombocytopenia caused by passively transfused anti - CD36 isoantibody . - pubmed
A novel small molecule CFTR inhibitor attenuates HCO3 - secretion and duodenal ulcer formation in rats . - pubmed
To further test this hypothesis , we examined the effect of a novel , potent , and highly selective CFTR inhibitor , CFTR ( inh )- 172 , on DBS and duodenal ulceration in rats . - pubmed
Duodenal ulcers were observed 24 h after cysteamine treatment but were reduced in CFTR(inh)-172 - pretreated rats . - pubmed
CFTR(inh)-172 acutely produces CFTR dysfunction in rodents for up to 24 h. CFTR inhibition reduces acid - induced DBS but also prevents duodenal ulcer formation , supporting our hypothesis that intracellular HCO ( 3 )(- ) may be an important protective mechanism for duodenal epithelial cells . - pubmed
In this review , we report the most up - dated findings about nuclear PI - PLC - beta1 , such as the localization in nuclear speckles , the activity changes during the cell cycle phases , and the possible involvement in the progression of myelodisplastic syndrome to acute myeloid leukemia . - pubmed
Sex - specific association of PTPN22 1858 T with type 1 diabetes but not with Hashimoto ' s thyroiditis or Addison ' s disease in the German population . - pubmed
BACKGROUND : Endocrine autoimmune disorders share genetic susceptibility loci , causing a disordered T - cell activation and homeostasis ( HLA class II genes , CTLA-4 ) . - pubmed
MATERIALS AND METHODS : Patients with type 1 diabetes ( n = 220 ) , Hashimoto ' s thyroiditis ( n = 94 ) , Addison ' s disease ( n = 121 ) and healthy controls ( n = 239 ) were genotyped for the gene polymorphism PTPN22 1858 C / T. RESULTS : Our study confirms a significant association between allelic variation of the PTPN22 1858 C / T polymorphism and type 1 diabetes mellitus ( T1D ) . - pubmed
No significant difference was observed between the distribution of PTPN22 C / T in patients with Hashimoto ' s thyroiditis or Addison ' s disease and healthy controls . - pubmed
CONCLUSION : The PTPN22 polymorphism 1858 C / T may be involved in the pathogenesis of type 1 diabetes mellitus by a sex - specific mechanism that contributes to susceptibility in females . - pubmed
Rates of hypertension , high low density lipoprotein ( LDL ) cholesterol , and diabetes mellitus awareness , treatment , and control for persons with a history of myocardial infarction and stroke were compared by using two nationally representative samples of the US population : the Third National Health and Nutrition Examination Survey in 1988 - 1994 ( n = 1,004 ) and the National Health and Nutrition Examination Survey in 1999 - 2002 ( n = 512 ) . - pubmed
Among such survivors , awareness of a previous diagnosis of hypertension and prevalence of self - reported diabetes mellitus remained stable while awareness of high LDL cholesterol increased from 43.3 % to 60.2 % ( p & lt ; 0.01 ) . - pubmed
Among those aware of their diagnosis , pharmacologic treatment for high LDL cholesterol increased from 33.1 % to 78.4 % and pharmacologic treatment for diabetes mellitus increased from 80.0 % to 93.6 % during this time ( each p & lt ; 0.01 ) , while pharmacologic treatment for hypertension increased nonsignificantly . - pubmed
Among those receiving pharmacologic treatment , hypertension and high LDL cholesterol control increased from 48.9 % to 59.3 % ( p = 0.05 ) and from 5.1 % to 33.1 % ( p & lt ; 0.01 ) , respectively . - pubmed
The number of US myocardial infarction and stroke survivors increased between 1988 - 1994 and 1999 - 2002 , and substantial improvements occurred in the awareness , treatment , and control of high LDL cholesterol in this population . - pubmed
Crystal - storing histiocytosis ( CSH ) is a rare disorder characterized by accumulation of immunoglobulin light chain within histiocytes in one or more organ systems , typically in association with multiple myeloma or , less frequently , with other conditions such as lymphoplasmacytic lymphoma , the use of certain medications , or even polyclonal gammopathies . - pubmed
Of serum samples collected from the first 19 patients , Rift Valley fever ( RVF ) virus RNA or immunoglobulin M ( IgM ) antibodies against RVF virus were found in samples from 10 patients ; all serum specimens were negative for yellow fever , Ebola , Crimean - Congo hemorrhagic fever , and dengue viruses . - pubmed
Effect of targeted magnetic nanoparticles containing 5 - FU on expression of bcl-2 , bax and caspase 3 in nude mice with transplanted human liver cancer . - pubmed
Tumor tissues were isolated for examination of the expression of bcl-2 , bax and caspase 3 by immunohistochemical method , reverse transcription polymerase chain reaction and Western blotting . - pubmed
CONCLUSION : The targeted magnetic nanoparticles containing 5 - FU can improve the chemotherapeutic effect of 5 - FU against hepatocellular carcinoma by decreasing the expression of bcl-2 gene , and increasing the expression of bax and caspase 3 genes . - pubmed
METHODS : Ninety - nine youth aged 7 - 17 yr with T2DM had a fasting blood sample for lipid and lipoprotein levels [ total cholesterol , low - density lipoprotein cholesterol ( LDL - c ) , high - density lipoprotein cholesterol , triglycerides ( TG ) ] , apolipoprotein B ( apoB ) , blood glucose , and hemoglobin A1c ( HbA1(C ) ) . - pubmed
ApoB levels exceeded the 75th % ile of the control population in 72 % of those with T2DM . - pubmed
Thirty - seven percent of those with T2DM had elevated TG and apoB levels . - pubmed
Elevated apoB levels with normal LDL - c levels highlight the importance of a full lipid panel including apoB in defining potential modifiable cardiovascular risk in this population with high rates of obesity , smoking , and poor glycemic control . - pubmed
A combined chemotherapy regimen comprising fludarabine , cytosine arabinoside , and granulocyte colony - stimulating factor ( FLAG ) has been used in the treatment of relapsed or refractory leukemias . - pubmed
Human trehalase ( TREH ) is expressed in the intestine and kidney and probably hydrolyzes ingested trehalose in the intestine and acts as marker of renal tubular damage in kidney . - pubmed
Neuronal death produced by cerebral ischemia activates innate immunity by Toll - like receptors and triggers inflammatory response . - pubmed
Molecular characterization and prognostic significance of FLT3 in CML progression . - pubmed
The induction of FLT3 in CML cells attenuated imatinib - induced apoptosis . - pubmed
OBJECTIVE : The primary objective was to study the epidemiology of Human Immunodeficiency Virus ( HIV ) positive tribal patients , and the secondary objective was to study the associated comorbidities in a tertiary care hospital in the tribal ( Bastar ) region of Chhattisgarh , India , between December 2006 and November 2008 , and their relation to CD4 counts . - pubmed
As a consequence , levels of CS - induced tumor necrosis factor - alpha and nitric oxide synthase , markers of inflammation , and 8 - hydroxy-2 - deoxyguanosine , a marker of DNA oxidation , were elevated in the aged mice compared with the young mice . - pubmed
CONCLUSION : The protective effect of BHR on renal function in rats with GS is possibly by way of influencing expressions of TGF - beta1 , TIMP-1 and MMP1 to regulate the state of extracellular matrix and lessen the matrix aggregation . - pubmed
The expression of TLRs in the CNS is variable and can be modulated by multiple factors , including pro - inflammatory molecules , which are elevated in neurodegenerative diseases and can increase the expression of TLRs in CNS cells . - pubmed
Therefore , TLRs have been shown to play a role in several aspects of neurodegenerative diseases . - pubmed
Here we will discuss results reported in the recent literature concerning the participation of TLRs in neurodegenerative diseases . - pubmed
In the media layer , Sv([Fbn-1 ] ) was 12,5 % greater in veins from women without edema and apoptosis was more detected in the veins from patients with edema . - pubmed
The current interest in developing Glycine transporter Type 1 ( GlyT-1 ) inhibitors , for diseases such as schizophrenia , has led to the demand for a GlyT-1 PET molecular imaging tool to aid drug development and dose selection . - pubmed
The orphan nuclear receptor LRH-1 and ERalpha activate GREB1 expression to induce breast cancer cell proliferation . - pubmed
BACKGROUND : Liver Receptor Homolog 1 ( LRH-1 , NR5A2 ) is an orphan nuclear receptor that is over - expressed in cancers in tissues such as the breast , colon and pancreas . - pubmed
In tumor cells , LRH-1 induces proliferation and cell cycle progression . - pubmed
High LRH-1 expression is demonstrated in breast cancers , positively correlating with ERalpha status and aromatase activity . - pubmed
LRH-1 dependent cellular mechanisms in breast cancer epithelial cells are poorly defined . - pubmed
Hence in the present study we investigated the actions of LRH-1 in estrogen receptor alpha ( ERalpha ) positive breast cancer cells . - pubmed
RESULTS : The study aimed to investigate LRH-1 dependent mechanisms that promote breast cancer proliferation . - pubmed
LRH-1 and ERalpha co - operatively activated transcription of ERE luciferase reporter constructs suggesting an overlap in regulation of target genes in breast cancer cells . - pubmed
CONCLUSIONS : We conclude that in ER - positive breast cancer cells , LRH-1 promotes cell proliferation by enhancing ERalpha mediated transcription of target genes such as GREB-1 . - pubmed
Collectively these findings indicate the importance of LRH-1 in the progression of hormone - dependent breast cancer and implicate LRH-1 as a potential avenue for drug development . - pubmed
The elevated level of alkaline phosphatase , hypophosphatemia and inappropriate phosphaturia suggested the diagnosis of hypophosphatemic osteomalacia secondary to proximal renal tubulopathy . - pubmed
This report highlights the importance of considering the diagnosis of osteomalacia in patients treated with tenofovir and emphasizes the need for monitoring alkaline phosphatase , blood and urinary phosphate and creatinine , especially in patients with risk factors for bone disease . - pubmed
Small GTPase R - Ras regulates integrity and functionality of tumor blood vessels . - pubmed
We show that R - Ras , a small GTPase of the Ras family , is essential for the establishment of mature , functional blood vessels in tumors . - pubmed
The genetic disruption of R - Ras severely impaired the maturation processes of tumor vessels in mice . - pubmed
Thus , R - Ras promotes normalization of the tumor vasculature . - pubmed
These findings identify R - Ras as a critical regulator of vessel integrity and function during tumor vascularization . - pubmed
Increased VWF antigen levels and decreased ADAMTS13 activity in preeclampsia . - pubmed
This study aimed to assess the von Willebrand factor ( VWF ) antigen levels and its proteolytic enzyme ADAMTS13 activity in preeclampsia . - pubmed
The plasma ADAMTS13 activity was significantly reduced in PE as compared with normal pregnancy and non - pregnant women ( P & lt ; 0.01 for both ) . - pubmed
In contrast , plasma VWF antigen and VWF RCO were significantly elevated in PE , as compared with normal pregnancy group as well as non - pregnant women ( P & lt ; 0.01 for both ) . - pubmed
In conclusion , reduction of plasma ADAMTS13 and elevation in VWF might have a role in the pathogenesis of PE . - pubmed
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation . - pubmed
We reported that Pla2g5 - null mice lacking group V secretory phospholipase A2 ( gV - sPLA2 ) showed reduced eosinophilic pulmonary inflammation and Th2 cytokine generation when challenged with an extract from house dust mite Dermatophagoides farinae , compared with wild - type ( WT ) controls . - pubmed
Adoptive transfer studies suggested that gV - sPLA2 in dendritic cells was necessary for sensitization of Pla2g5 - null mice , but was not sufficient to induce the effector phase of pulmonary inflammation . - pubmed
In this study , we demonstrate that gV - sPLA2 is inducibly expressed in mouse and human macrophages ( M ) activated by IL-4 and is required for the acquisition of M effector functions that facilitate the effector phase of pulmonary inflammation . - pubmed
We demonstrate that gV - sPLA2 expression in M is sufficient for the development of pulmonary inflammation , even when inflammation is induced by intrapulmonary administration of IL-4 . - pubmed
farinae - challenged WT donor mice induce eosinophilia , chemokine production , and recruitment of T cells into the lungs of Pla2g5 - null recipients previously sensitized by WT D. - pubmed
Our studies identified a unique function of gV - sPLA2 in activation of M and in their capacity to recruit T cells to amplify the effector phase of pulmonary inflammation . - pubmed
This study was designed to investigate the potential role of induction of HSP70 using geranylgeranylacetone ( GGA ) on testicular damage caused by CCl4 . - pubmed
These findings suggest that GGA - induced activation of HSP 70 significantly alleviate CCl4 inflicting testicular damage by HSP 70 mediated cytoprotection and antioxidant effects . - pubmed
In a recent issue of Cell , Leprivier and colleagues demonstrate that eEF2 K , which can inhibit translation elongation acutely during protein synthesis , is a critical switch in the survival versus death fate of starved cancer cells . - pubmed
Human T cell leukemia virus type 1 ( HTLV-1 ) is associated with a neurological syndrome named tropical spastic paraparesis / HTLV - associated myelopathy ( TSP / HAM ) and the disease progression involves viral factors . - pubmed
This study aimed to assess the molecular diversity of gp21 and HBZ proteins in TSP / HAM and healthy carriers . - pubmed
[ Interleukin-2 ( Ronkoleykin ) in the first - line chemotherapy for B - cell non - Hodgkin lymphoma ] . - pubmed
In this paper we present the results of a randomized prospective study , in which we examined the influence of rIL-2 ( " Ronkoleykin " ) on the effectiveness of the R - CHOP combination in the first - line treatment of patients with B - cell non - Hodgkin lymphomas . - pubmed
It was found that the inclusion of rIL-2 in the R - CHOP regimen increased the effectiveness of the treatment of B - cell NHL with a high - risk of poor disease 's course . - pubmed
Pertussis vaccine antigen - specific IgG levels , antibody avidities , and IgG subclasses , as well as T - cell cytokine levels , were measured by fluorescent bead - based multiplex immunoassays . - pubmed
The association between the HLA system and retinopathy development in patients with type 1 diabetes mellitus . - pubmed
The aim of this study was to determine the role of the HLA system in the development of DR in patients with type 1 diabetes mellitus . - pubmed
The study confirms the influence of HLA genes in the development of DR in Croatian type 1 diabetic patients . - pubmed
In our patients , susceptibility to PDR appears to be primarily associated to DQB1 * 0201 with the relative risk , RR = 5.29 and DQB1 * 0302 ( RR = 2.84 ) . - pubmed
Anti - NMDAR encephalitis misdiagnosed as Hashimoto ' s encephalopathy . - pubmed
Anti - N - methyl - D - aspartate receptor ( NMDAR ) encephalitis is a well - defined autoimmune disorder . - pubmed
We described a 14 - year - old - girl presenting with a clinical picture consistent with the diagnosis of anti - NMDAR encephalitis , confirmed by NMDAR antibody testing . - pubmed
Anti - NMDAR encephalitis and HE share similar clinical features so that the differential diagnosis can be difficult if specific antibodies are not tested . - pubmed
The correct diagnosis of anti - NMDAR encephalitis is crucial to plan the appropriate management and follow - up , namely in term of oncological screening , since it can be paraneoplastic in origin . - pubmed
We suggest to re - evaluate the clinical history of all subjects with previous HE diagnosis in order to evaluate the possible diagnosis of anti - NMDAR encephalitis and plan the appropriate management of these patients . - pubmed
To address this potential limitation , we examined the regional LD pattern of leucine - rich repeat kinase 2 ( LRRK2 ) gene , which is responsible for both autosomal dominant and sporadic Parkinson ' s disease ( PD ) , in Caucasians ( CEU ) , Japanese ( JPT ) and Chinese ( CHB ) from HapMap and Chinese ( CHS ) , Malays ( MAS ) and Indians ( INS ) from the Singapore Genome Variation Project ( SGVP ) utilizing the traditional heatmaps and targeted analysis of LRRK2 gene via Monte Carlo simulation through varLD scores of these ethnic groups . - pubmed
Our study suggests that there is a higher chance to detect associations between PD and those trait - associated SNPs of LRRK2 gene found in Caucasian studies in INS , while those found in Japanese studies are likely to be better replicated among CHB . - pubmed
OBJECTIVE : To study the association between Epstein Barr ( EB ) virus A73 gene polymorphism and nasopharyngeal carcinoma ( NPC ) in a Chinese Han population . - pubmed
On the other hand , only 3 inhibited inflammatory parameters such as hyperalgesia , edema , and local production of TNF - alpha following induction with complete Freund 's adjuvant . - pubmed
Brain - derived neurotrophic factor ( BDNF ) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes . - pubmed
Here we examined the influence of a variant in the brain - derived neurotropic factor ( BDNF ) gene ( Val66Met ) , which underlies synaptic plasticity throughout the central nervous system , on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation . - pubmed
Infant , but not maternal , BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure . - pubmed
Thus , antenatal Maternal Anxiety x BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus . - pubmed
Arabidopsis RNA - dependent RNA polymerases and dicer - like proteins in antiviral defense and small interfering RNA biogenesis during Turnip mosaic virus infection . - pubmed
We report a case of multiple lung metastases of an epithelioid sarcoma originating in the inguinal area that we treated with the multikinase inhibitor pazopanib . - pubmed
Forkhead box M1 ( FoxM1 ) , a transcription factor of the Forkhead family , is demonstrated to be critical for proliferation , apoptosis , migration and invasion of lung cancer . - pubmed
Successful treatment of FKBP51 - expressed multicentric reticulohistiocytosis using combination therapy with low - dose denosumab and tacrolimus . - pubmed
Bone Marrow Mononuclear Cell Transplantation Restores Inflammatory Balance of Cytokines after ST Segment Elevation Myocardial Infarction . - pubmed
Here , we studied in detail the acute effect of bone marrow mononuclear cell ( BMMNC ) transplantation on proinflammatory and anti - inflammatory cytokines in patients with ST segment elevation myocardial infarction ( STEMI ) . - pubmed
CONCLUSIONS : BMMNC transplantation is associated with preserved balance between pro- and anti - inflammatory cytokines after STEMI in PCI - treated patients . - pubmed
A Novel Nonsense Mutation in DNAJC6 Expands the Phenotype of Autosomal - Recessive Juvenile - Onset Parkinson ' s Disease . - pubmed
Bronchial lavage P 16INK4A gene promoter methylation and lung cancer diagnosis : A meta - analysis . - pubmed
OBJECTIVE : To evaluate the diagnostic value of bronchial lavage P16INK4A promoter methylation and lung cancer . - pubmed
MATERIALS AND METHODS : The databases of PubMed , Medline , China National Knowledge Infrastructure , and Wanfang were electronically searched by two reviewers to find the suitable studies related to the association between P16INK4A promoter methylation and lung cancer . - pubmed
The diagnostic sensitivity , specificity , and area under the receiver operating characteristic ROC curve of bronchial lavage P16INK4Aas a biomarker for diagnosis of lung cancer were pooled by stata 11.0 software ( Stata Corporation , College Station , TX , USA ) . - pubmed
The pooled sensitivity and specificity of bronchial lavage P16INK4A promoter methylation for lung cancer diagnosis were 0.61 ( 95 % confidence interval [ CI ] : 0.57 - 0.65 ) and 0.81 ( 95 % CI : 0.78 - 0.85 ) , respectively , with random effect model . - pubmed
The systematic area under the ROC was 0.72 ( 95 % CI : 0.68 - 0.76 ) , which indicated that the diagnostic value of bronchial lavage P16INK4A promoter methylation for lung cancer was relatively high . - pubmed
CONCLUSION : Bronchial lavage P16INK4A promoter methylation can be a potential biomarker for diagnosis of lung cancer . - pubmed
This study evaluates the nuclear and mitochondrial DNA integrity of prostate carcinoma cells , CAS , matched benign epithelium and benign epithelium - associated stroma by whole - genome copy - number analyses , targeted sequencing of TP53 , and FISH . - pubmed
No somatic TP53 mutations were observed in CAS . - pubmed
Despite the relatively modest ColR - dependent changes of wild - type , colR deficiency resulted in drastic proteome alterations , with 122 proteins up- and 62 down - regulated by zinc . - pubmed
HSV-2 infection resulted in the activation of PI3 K and Akt in the host cells , and BX-795 treatment inhibited HSV-2 - induced Akt phosphorylation and activation . - pubmed
HSV-2 infection increased the phosphorylation of JNK and p38 , and reduced ERK phosphorylation at 8 h postinfection in the host cells ; BX-795 treatment inhibited HSV-2 - induced activation of JNK and p38 MAP kinase as well as the phosphorylation of c - Jun and ATF-2 , the downstream targets of JNK and p38 MAP kinase . - pubmed
RESULTS : 21.4 % of patients received no treatment , 20.8 % received ipilimumab and 57.5 % of patients with BRAF - positive tumors received vemurafenib / dabrafenib . - pubmed
Primary rat TM epithelial cell cultures positive for pancytokeratin had colony forming activity and could be enriched for CK 19 - positive cells that were capable of culture expansion by proliferation and cell migration when subject to a wound assay . - pubmed
Methods : Biomarkers of endothelial activation and injury , immune functions , platelet activation and insulin resistance were measured in 8 - week old male C57BL/6 mice exposed to commercial snuff , CRP-2 reference snuff , commercial snus , CRP-1 reference snus , and nicotine in drinking water ( 100 microg / mL ) for 4 , 12 , and 24 weeks . - pubmed
Increased formation of proinflammatory cytokines such as TNFalpha by nicotine or Copenhagen snuff may lead to vascular inflammation and thereby exacerbate atherogenesis . - pubmed
In the late 1980s , when GLUT4 , the major insulin - regulated glucose transporter , was identified , my lab observed that it was downregulated in adipocytes but not in skeletal muscle in insulin - resistant states , such as obesity and type 2 diabetes , in humans and rodents . - pubmed
AMPK activation protects against diet induced obesity through Ucp1 - independent thermogenesis in subcutaneous white adipose tissue . - pubmed
Conclusion : Fecal transplantation can alleviate lipopolysaccharide - induced acute lung injury in rats , and its regulatory effect may be related to inhibiting the activation of PI3K / AKT / NF - kappaB signaling pathway and reducing the expression of inflammatory factor ICAM-1 . - pubmed
Azoramide improves mitochondrial dysfunction in palmitate - induced insulin resistant H9c2 cells . - pubmed
Although the effect of azoramide in glucose - homeostasis in mammalians is not known very well , a limited number of experimental studies showed that it could improve the insulin sensitivity in genetically obese mice . - pubmed
Durable Response of Low - Dose Afatinib plus Cetuximab in an Adenocarcinoma Patient with a Novel EGFR Exon 20 Insertion Mutation . - pubmed
Orientin suppresses oxidized low - density lipoproteins induced inflammation and oxidative stress of macrophages in atherosclerosis . - pubmed
RAW 264.7 were treated with 80 mug / mL oxidized low - density lipoproteins ( ox - LDL ) to mimic atherosclerosis in vitro . - pubmed
Orientin inhibited ox - LDL - induced inflammation and oxidative stress , and CD36 may be the key regulator during Orientin action . - pubmed
Despite its physiologic importance in maintaining angiogenic balance , excess sFlt-1 levels are associated with the pathogenesis of many diseases , especially those with angiogenic imbalance , endothelial dysfunction , and hypertension . - pubmed
Sarcopenia and COVID-19 : A Manifold Insight on Hypertension and the Renin Angiotensin System . - pubmed
Safety and Clinical Activity of MEDI0562 , a Humanized OX40 Agonist Monoclonal Antibody , in Adult Patients With Advanced Solid Tumors . - pubmed
A meta - analysis of the prognostic significance of Golgi protein 73 in hepatocellular carcinoma in Chinese patients . - pubmed
Introduction : In recent years , an increasing number of studies have revealed the possible prognostic significance of Golgi protein 73 ( GP73 ) in hepatocellular carcinoma ( HCC ) , but the results are still controversial . - pubmed
Therefore , we performed a meta - analysis to explore the possible correlation between GP73 and prognostic value in HCC . - pubmed
The results indicated that GP73 overexpression was significantly associated with later tumour stage , higher tumour grade and poor overall survival ( OS ) . - pubmed
Combined analysis of three studies showed no statistical correlation between high GP73 expression and disease - free survival ( DFS ) . - pubmed
Conclusions : The meta - analysis suggested that overexpression of GP73 may be associated with poor prognosis in HCC and may also have a predictive role for HCC invasion and metastasis . - pubmed
Recent Discoveries in the Androgen Receptor Pathway in Castration - Resistant Prostate Cancer . - pubmed
The androgen receptor ( AR ) is the main therapeutic target in advanced prostate cancer , because it regulates the growth and progression of prostate cancer cells . - pubmed
The circulating miR-146a level was significantly lower in patients with CML than in healthy subjects and showed a significant rise after 14 days of imatinib treatment and an inverse correlation with BCR - ABL expression levels at 90 days . - pubmed
Stapled Peptides Based on Human Angiotensin - Converting Enzyme 2 ( ACE2 ) Potently Inhibit SARS - CoV-2 Infection In Vitro . - pubmed
SARS - CoV-2 uses human angiotensin - converting enzyme 2 ( ACE2 ) as the primary receptor to enter host cells and initiate the infection . - pubmed
Here , we report the design of four stapled peptides based on the ACE2 helix , which is expected to bind to SARS - CoV-2 and prevent the binding of the virus to the ACE2 receptor and disrupt the infection . - pubmed
The aims of this study were ( i ) to determine whether different metabolic profiles of B - vitamins and vitamin A in Brazilian children and adolescents were positively or negatively related to homocysteine and omega-3 fatty acids using k - means clustering analysis , ( ii ) compare nutrient intakes and metabolites between the different metabolic profiles , ( iii ) evaluate if the statistically significant metabolites found between the metabolic groups , can predict the variation of leukotriene A4 hydrolase ( LTA4H ) levels , a biomarker of low - grade inflammation , in the total studied population . - pubmed
Integrin beta1 plays an essential role in the crosstalk between tumor cells and their microenvironment . - pubmed
Women with 21OHD have reduced fertility because of excessive production of adrenal androgen and progesterone , which can inhibit folliculogenesis , disturb the normal gonadotropin secretion pattern and development of the endometrium , and affect endometrial receptivity . - pubmed
They do not stimulate the production of antibodies at all or only very slightly , reduce insulin resistance and allergic reactions , cause lipodystrophies to disappear and lower the insulin requirement . - pubmed
Whether these insulins can also reduce vascular complications can not yet be finally decided . - pubmed
S-100 staining for the diagnosis of melanoma of the anal canal . - pubmed
Structural and expression analyses of normal and mutant mRNA encoding glycine decarboxylase : three - base deletion in mRNA causes nonketotic hyperglycinemia . - pubmed
We studied the structure of the mutant P - protein mRNA expressed in the liver of a patient with nonketotic hyperglycinemia ( NKH ) deficient of P - protein . - pubmed
Functional and phenotypic characteristics of effusion - associated lymphoid cells cultured in the presence of either recombinant interleukin 2 or T - cell growth factor from malignant pleural and peritoneal effusions in patients with advanced carcinoma . - pubmed
Malignant pleural or peritoneal effusion - associated lymphoid ( EAL ) cells from 17 patients with advanced carcinoma were cultured with autologous carcinoma cells in the presence of either recombinant interleukin 2 ( rIL 2 ) or T - cell growth factor ( TCGF ) . - pubmed
In facts , viable carcinoma cells co - cultured with EAL cells and TCGF mostly disappeared during 14 days . - pubmed
The majority of killer - effector cells against allogeneic cells in rIL 2 - activated EAL cells from cancer patients showed CD4+Leu8- phenotype at population level . - pubmed
In order to establish the possible existence of a cardiac converting enzyme and its role in the pathophysiology of the myocardial ischemia , the direct cardiac effects of IEC and AI or AII were studied on the isolated rat heart perfused through the left atria . - pubmed
Double esterase ( DE ) positivity in AML cells . - pubmed
Differential reactivity of rheumatoid synovial cells and serum rheumatoid factors to human immunoglobulin G subclasses 1 and 3 and their CH3 domains in rheumatoid arthritis . - pubmed
19S IgM rheumatoid factors ( RF ) are polyclonal autoantibodies that may play an important pathogenic role in sustaining inflammatory synovitis in rheumatoid arthritis ( RA ) . - pubmed
RF in RA have reactivity for as - yet - uncharacterized antigenic determinants in IgG Fc . - pubmed
In 10 patients with cat asthma and hay fever , we quantified the doses of cat allergen ( expressed as cat allergen 1 [ Cat-1 ] in log Food and Drug Administration [ FDA ] units ) inspired from the ambient air of a room containing living cats required to induce a 20 % drop in FEV1 . - pubmed
Defects of thrombin - induced protein phosphorylation in platelets from stroke - prone spontaneously hypertensive rats . - pubmed
[ Cholinesterase activity in the humor of the anterior chamber and in the blood in patients with glaucoma and cataract ] . - pubmed
[ Value of serum ornithine carbamoyltransferase activity in the diagnosis liver diseases ] . - pubmed
Increased thyrotrophin and prolactin secretion induced by domperidone in hypothyroid subjects . - pubmed
The thyrotrophin ( TSH ) and prolactin ( Prl ) releasing effects of domperidone , a recently developed antidopaminergic drug which does not cross the blood - brain barrier , were investigated in 8 women affected by primary hypothyroidism , and were compared to those elicited by another antidopaminergic drug , sulpiride . - pubmed
In streptozotocin induced diabetic rats , the amylase content and amylase release from isolated pancreatic acini stimulated by CCK-8 were significantly decreased . - pubmed
Both decrease could be reversed when vanadate , a chemical which is capable of lowering blood glucose without effect on serum insulin level in diabetic rats , was given intragastrically . - pubmed
Clomipramine - induced agranulocytosis and its treatment with G - CSF . - pubmed
Moreover , binding of gC to two heparan sulfate - deficient L - cell lines , gro2C and sog9 , both of which are mostly resistant to HSV infection , was markedly reduced . - pubmed
Hematopoietic growth factors for the treatment of severe chronic neutropenia . - pubmed
, congenital neutropenia ( Kostmann ' s syndrome and related syndromes ) , idiopathic neutropenia ( both childhood and adult ) , and cyclic neutropenia , it is now established that long - term treatment with the hematopoietic growth factor , recombinant human granulocyte colony stimulating factor ( rHuG - CSF or Filgrastim ) , can elevate blood neutrophil counts to the normal range in most patients , with a concomitant reduction in infection - related events including fever , oral ulcerations , antibiotic use and symptoms of inflammation . - pubmed
Before the discovery of the BRCA1 and BRCA2 genes , if a first - degree relative in direct genetic lineage had hereditary breast cancer or hereditary breast - ovarian cancer syndrome , the best estimate of family members ' genetic risk for breast cancer was 50 % . - pubmed
Now the lifetime cancer destiny of a patient who carries a BRCA1 or BRCA2 germ line mutation can be determined with an extraordinary degree of precision . - pubmed
In this study we have used ARL 66096 , a potent antagonist of ADP - induced platelet aggregation , and a P2X ionotropic receptor agonist , alpha , beta - methylene adenosine 5 '- triphosphate , to distinguish the ADP - induced intracellular events . - pubmed
Furthermore , the decline of MnSOD mRNA and MnSOD activity levels coincides with increasing cytotoxicity . - pubmed
Role of transforming growth factor - beta pathway in the mechanism of wound healing by saponin from Ginseng Radix rubra . - pubmed
The effects of saponin from Ginseng Radix rubra on extracellular matrix metabolism , the activation and synthesis of TGF - beta1 , and the modification of TGF - beta receptor in fibroblasts were examined to elucidate the contribution of the TGF - beta pathway to the mechanism of wound healing by saponin . - pubmed
Recently , we have shown that hyperinsulinemia increases the activity of farnesyltransferase ( FTase ) in vitro ( 1 ) and in hyperinsulinemic animals ( 2 ) , stimulates the phosphorylation of the FTase alpha - subunit ( 3 ) , increases the amounts of cellular farnesylated p21Ras ( 4 ) , and potentiates the nuclear effects of other peptide growth factors , such as EGF , IGF-1 and PDGF ( 5 ) . - pubmed
Analysis of Chlamydomonas reinhardtii sta11 - 1 mutants revealed a correlation between a D - enzyme deficiency and specific alterations in amylopectin structure and starch biosynthesis , thereby suggesting previously unknown biosynthetic functions . - pubmed
A mutation in the 5 ' non - high mobility group box region of the SRY gene in patients with Turner syndrome and Y mosaicism . - pubmed
Mutations of SRY ( testis - determining gene ) constitute the cause of XY sex reversal in approximately 10 - 15 % of females with pure gonadal dysgenesis . - pubmed
We carried out molecular studies of the SRY gene in three patients with a UTS phenotype and bilateral streaks ; two presented a 45,X/46,XY mosaic , and the third a Y marker chromosome . - pubmed
A previous report of a 46,XY patient with partial gonadal dysgenesis who presented the same mutation as our patients indicates the probable existence of a hot spot in this region of the SRY gene and strengthens the possibility that all gonadal dysgeneses constitute part of a spectrum of the same disorder . - pubmed
In the RVM of decerebrate piglets 2 - 15 days of age , we studied the effects of electrolytic lesions ( n=7 ) or microdialysis of muscimol ( n=15 ) , a GABAA receptor agonist , on ventilatory output and the response to hypercapnia . - pubmed
Substance P induced histamine release from nasal mucosa of subjects with and without allergic rhinitis . - pubmed
CONCLUSION : These findings suggest a role of SP in inducing release of histamine from human nasal mucosa , thereby influencing physiologic and pathophysiologic nasal conditions , especially in allergic inflammatory processes . - pubmed
The deregulated tyrosine kinase activity of the BCR - ABL fusion protein is the cause of malignant transformation in almost all cases of chronic myelogenous leukaemia ( CML ) , making BCR - ABL an ideal target for pharmacological inhibition . - pubmed
Studies by immunoblotting using membrane fractions from peripheral blood or spleen from normal mice where reticulocytosis was induced by erythropoietin ( EPO ) or phenylhydrazine ( PHZ ) treatment suggest that DMT1 is coexpressed with transferrin receptor ( TfR ) in erythroid cells . - pubmed
The metastasis gene osteopontin : a candidate target for cancer therapy . - pubmed
The cytokine osteopontin is essential for the dissemination of various cancers . - pubmed
Past research has implied several modes in which osteopontin and its main receptors on tumor cells can be suppressed . - pubmed
The receptor integrin alpha ( V ) beta ( 3 ) contributes not only to tumor cell dissemination , but also to angiogenesis and osteolysis in bone metastases . - pubmed
Myocardial ischemic injury after heart transplantation is associated with upregulation of vitronectin receptor ( alpha ( v ) beta3 ) , activation of the matrix metalloproteinase induction system , and subsequent development of coronary vasculopathy . - pubmed
Matrix metalloproteinases ( MMPs ) are activated in ischemic injury models . - pubmed
At 1 year , MMPs were evaluated , and interstitial myocardial fibrosis was quantified . - pubmed
Compared with control , the ischemia group demonstrated evidence of significant increased expression of alpha ( v ) beta3 ( 3.2 - fold , P<0.001 ) , tissue factor ( 2.5 - fold , P<0.001 ) , and EMMPRIN ( 1.9 - fold , P=0.01 ) . - pubmed
At 1 year , the ischemia group had a significant increase in myocardial fibrosis ( 24+/-1.8 % versus 14+/-1.1 % , P<0.001 ) and zymographic activity of MMP-2 ( 1.4 - fold , P<0.001 ) , MMP-3 ( 1.2 - fold , P<0.001 ) , and MMP-9 ( 1.3 - fold , P=0.01 ) . - pubmed
CONCLUSIONS : Myocardial ischemic injury after cardiac transplantation is associated with upregulation of alpha ( v ) beta3 , tissue factor , and activation of the MMP induction system , which may contribute to the subsequent development of allograft remodeling and vasculopathy . - pubmed
RESULTS : By using 2 - dimensional proteomics , a protein fraction at 40 kd was recognized by serum IgE from 86 % ( 12/14 ) of the patients with hazelnut allergy with systemic reactions . - pubmed
BAX and BAK are essential regulators of proapoptotic signaling , and the disruption of apoptosis is linked to the development of cancer . - pubmed
In contrast , E1A- and p53DD - transformed BAX- and BAK - deficient BMKs formed highly invasive carcinomas . - pubmed
Transformed BMKs deficient for either BAX or BAK were also tumorigenic , but only when heterozygous for the remaining bax or bak allele , the expression of which was lost in most resulting tumors . - pubmed
Several members of the FGF family , in particular FGF2 , are intimately involved in neuronal protection and repair after ischemic , metabolic or traumatic brain injury . - pubmed
Expression of Fgf2 mRNA and protein is strongly upregulated after neuronal damage , with glial cells as the predominant source . - pubmed
Given its survival - promoting effects on cultured neurons , exogenous FGF2 was tested in several animal models of stroke and excitotoxic damage , in which it consistently proved protective against neuronal loss . - pubmed
Despite the well - documented benefits of FGF2 in animal models of stroke , there is currently no clinical development in stroke , after a phase II / III trial with FGF2 in acute stroke patients was discontinued because of an unfavorable risk - to - benefit ratio . - pubmed
Cytochrome P450 ( CYP ) 1A1 has long been known to be one of the metabolic enzymes involved in activating many procarcinogens , the first step toward tumor formation during chemical carcinogenesis . - pubmed
Apart from recent findings of constitutive activation of some transcription factors and autocrine stimulation by cytokine receptors , the mechanisms of malignant transformation in cHL still remain poorly understood . - pubmed
Several of the differentially expressed genes may play a role in the pathogenesis of cHL because they represent potential oncogenes , such as rhoC , L - myc , and PTP4A , or transcription factors , such as ATF-5 , ATBF1 , and p21SNFT . - pubmed
[ Serum lipoproteins in hypertonic disease ] . - pubmed
Depression by relaxin of neurally induced contractile responses in the mouse gastric fundus . - pubmed
In vivo magnetic resonance imaging of coronary thrombosis using a fibrin - binding molecular magnetic resonance contrast agent . - pubmed
BACKGROUND : The advent of fibrin - binding molecular magnetic resonance ( MR ) contrast agents and advances in coronary MRI techniques offers the potential for direct imaging of coronary thrombosis . - pubmed
We tested the feasibility of this approach using a gadolinium ( Gd)-based fibrin - binding contrast agent , EP-2104R ( EPIX Medical Inc ) , in a swine model of coronary thrombus and in - stent thrombosis . - pubmed
METHODS AND RESULTS : Ex vivo and in vivo sensitivity of coronary MR thrombus imaging was tested by use of intracoronarily delivered Gd - DTPA - labeled fibrinogen thrombi ( n=6 ) . - pubmed
Fibrinogen thrombi : 5 of 6 intracoronarily delivered Gd - labeled fibrinogen clots ( approximately 250 micromol / L Gd ) were visible on MRI and subsequently confirmed by x - ray angiography . - pubmed
CONCLUSIONS : We demonstrate the feasibility of MRI of coronary thrombus and in - stent thrombosis using a novel fibrin - binding molecular MR contrast agent . - pubmed
There was high agreement between Hb in capillary blood by the HemoCue and in venous blood by the counter ( r icc=0.86 ; p<0.01 ) , and also between the diagnosis of anemia by both equipments ( k=0.81 ; p<0.01 ) . - pubmed
The presence of CD5 , CD10 , and Bcl-1 co - expression by immunohistochemistry and detectable t(11;14 ) and cMYC gene rearrangement by FISH analyses in the Burkitt region support a transformation of mantle cell lymphoma over a concomitant malignancy . - pubmed
A limited number of mantle cell lymphomas demonstrating dual t(11;14 ) and chromosome 8q24 cMYC gene rearrangements have been previously reported in the literature . - pubmed
CASE REPORT : Child with left middle cerebral artery territory infarction in which several thromboembolic risk factors were documented both in the child ( neonatal sepsis and factor V Leiden ) and his mother ( lupus anticoagulant , pre - eclampsy and factor V Leiden ) . - pubmed
The endothelin system and its role in pulmonary arterial hypertension ( PAH ) . - pubmed
The diagnosis was confirmed by liver biopsy proven decreased AGT activity in 68 % of cases , hyperoxaluria in 74 % , hyperglycolicaciduria in 37 % and hyperoxalaemia in 50 % . - pubmed
In the present study , we show that subtoxic concentrations of curcumin sensitize human renal cancer cells to the tumor necrosis factor - related apoptosis inducing ligand ( TRAIL)-mediated apoptosis . - pubmed
A common dermatological finding in many SLE - prone mouse strains is the deposition of immunoglobulins at the dermoepidermal junction . - pubmed
Over the past decade , the most exciting and important finding has been the discovery of the Fas - defect in the pathogenesis of the autoimmune MRL / lpr mouse , which is a good model for the spontaneous development of skin lesions similar to those seen in human LE . - pubmed
The analysis of MRL / lpr mice showed a close association between immunoglobulin deposits and the appearance of skin lesions . - pubmed
Cutaneous LE lesions can also be induced in TCRalpha-/- mice treated with fluorouracil and ultraviolet B light irradiation . - pubmed
Plasma cytokine concentrations were significantly larger in the endotoxemia group than in the other groups . - pubmed
IMPLICATIONS : Sevoflurane pretreatment decreased mortality rate , severity of hypotension , and acidosis , and inhibited cytokine responses in rats injected with endotoxin , suggesting that sevoflurane may be an anesthetic of choice in endotoxemic states . - pubmed
Some patients show normal ALT levels , whereas others develop severe hepatitis exacerbations ( SHEs ) due to YMDD mutants . - pubmed
Patients with SHE had more substitutions in the reverse transcriptase ( rt ) region within the polymerase gene at the time of exacerbation than those without SHE , although no specific substitutions were noted . - pubmed
The mechanism of latex allergy and the immune responses following reexposure of latex allergens by the intranasal route was studied in a murine model of latex allergy developed by intragastric sensitization with NRL . - pubmed
Biliary excretion was investigated in mdr1a / b - knockout mice , Bcrp - knockout mice and Mrp2 - defective Eisai hyperbilirubinemic rats ( EHBRs ) . - pubmed
Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells . - pubmed
Besides damage to several tissues in vivo , AZA-1 has been shown to cause cytotoxicity in a number of cell lines and alterations in actin cytoskeleton and cell morphology . - pubmed
The JNK inhibitor SP600125 seemed to slightly diminish AZA-1 effects , however due to the effects of the drug by itself the involvement of JNK in AZA-1 toxicity needs further investigation . - pubmed
Cytotoxicity of AZA-1 has been previously described without reference to the type of cell death , we report that AZA-1 induces the activation of caspases , commonly used as an early marker of apoptosis , and that these proteases are not responsible for AZA-1 - induced cytoskeleton disarragement in human neuroblastoma cells . - pubmed
Five important forms of nonallergic angioedema can be distinguished : hereditary ( HAE ) , acquired ( AAE ) , renin - angiotensin - aldosterone system ( RAAS)-blocker - induced ( RAE ) , pseudoallergic angioedema ( PAE ) and idiopathic angioedema ( IAE ) . - pubmed
Today , a plasma pool C1 - esterase inhibitor ( C1 - INH ) concentrate is the therapy of choice in HAE . - pubmed
According to currently available reports , these drugs may improve the treatment of kinin - induced angioedema . - pubmed
SIRT1 activation confers neuroprotection in experimental optic neuritis . - pubmed
The authors examined potential neuroprotective effects in optic neuritis by SRT647 and SRT501 , two structurally and mechanistically distinct activators of SIRT1 , an enzyme involved in cellular stress resistance and survival . - pubmed
Treatment with either SIRT1 activator did not prevent EAE or optic nerve inflammation . - pubmed
CONCLUSIONS : SIRT1 activators provide an important potential therapy to prevent the neuronal damage that leads to permanent neurologic disability in optic neuritis and MS patients . - pubmed
Intravitreal administration of SIRT1 activators does not suppress inflammation in this model , suggesting that their neuroprotective effects will be additive or synergistic with current immunomodulatory therapies . - pubmed
Intravenous immunoglobulin therapy of lupus pneumonitis . - pubmed
The role of intravenous immunoglobulin during acute life threatening pulmonary emergencies in a case of SLE prompted this clinical brief . - pubmed
Huntington ' s disease is caused by an abnormal CAG expansion within the gene encoding Huntingtin which induces a major cortico - striatal degeneration as well as motor and cognitive impairments . - pubmed
Polymorphisms in the promoter region of the basic fibroblast growth factor gene and proliferative diabetic retinopathy in Caucasians with type 2 diabetes . - pubmed
BACKGROUND : Basic fibroblast growth factor ( bFGF ) expression is implicated in proliferative diabetic retinopathy ( PDR ) . - pubmed
The aim of this study was to investigate the association of genetic polymorphisms ( -553T / A , -834T / A and -921C / G ) in the promoter region of the bFGF gene with PDR in patients with type 2 diabetes . - pubmed
We analysed serum bFGF levels in 78 subjects with type 2 diabetes and 25 subjects without diabetes . - pubmed
Significantly higher bFGF serum levels were demonstrated in diabetics with the AT genotype of the -553 polymorphism compared with diabetics with the TT genotype , whereas the -834 and -921 polymorphisms failed to affect serum bFGF levels . - pubmed
Response to prednisone in relation to NR3C1 intron B polymorphisms in childhood nephrotic syndrome . - pubmed
We genotyped 118 children diagnosed with NS who initially responded to oral GC treatment [ steroid - responsive nephrotic syndrome ( SRNS ) group ] and 136 healthy children for three intron B single nucleotide polymorphisms of NR3C1 , namely Bcl I ( C / G ) , rs33389 ( C / T ) and rs33388 ( A / T ) . - pubmed
In the SRNS group , we performed a three - marker haplotype analysis of NR3C1 in relation to the response to prednisone , represented as time to proteinuria resolution ( TPR ) as categorical and ordinal variable . - pubmed
High nuclear Livin expression is a favourable prognostic indicator in renal cell carcinoma . - pubmed
OBJECTIVES : To assess the protein expression of Livin , an apoptosis inhibitor , in renal cell carcinoma ( RCC ) and to determine its prognostic relevance . - pubmed
PATIENTS AND METHODS : Immunohistochemical staining for Livin was performed in tissue microarrays ( TMAs ) , including tumour tissue cores , from patients with RCC who had undergone renal surgery . - pubmed
In 682 TMAs cytoplasmatic staining intensity and nuclear staining quantity were evaluated , and the association of Livin expression with progression - free survival ( PFS ) and cancer - specific survival ( CSS ) was analysed with a multivariate Cox regression model . - pubmed
In multivariate analysis , high ( & gt;25 % ) nuclear Livin expression was a favourable independent predictor of PFS and CSS even after adjusting for tumour stage , Fuhrman grade , age , sex and Karnofsky severity rating . - pubmed
CONCLUSION : High nuclear Livin expression is a favourable independent predictor of PFS and CSS in patients with RCC . - pubmed
CONCLUSIONS : BRCA mutation carriers were more likely to believe PM to be the best way to reduce both risk and worry of breast cancer . - pubmed
METHODS : Two hundred twenty - six men from families with a known BRCA1 or BRCA2 mutation were recruited through an epidemiological database of high - risk breast cancer families and completed a self - administered questionnaire . - pubmed
Hence , some of the assumptions about what makes information on BRCA1 or BRCA2 status salient to men and may therefore influence their attendance at a cancer genetic clinic are not borne out in this study . - pubmed
ebr3 has an elevated expression of PBZ1 and PR1 only in tissue displaying the LM phenotype . - pubmed
ncr1 strongly expresses PBZ1 in tissue displaying the LM phenotype , whereas PR1 expression in this tissue is similar to wild - type CO39 . - pubmed
Day 3 thymectomy ( D3Tx ) results in a loss of peripheral tolerance mediated by natural regulatory T cells ( nTregs ) and development of autoimmune ovarian dysgenesis ( AOD ) and autoimmune dacryoadenitis ( ADA ) in A / J and ( C57BL/6J x A / J ) F(1 ) hybrids ( B6A ) , but not in C57BL/6J ( B6 ) mice . - pubmed
Visualizing the role of Cbl - b in control of islet - reactive CD4 T cells and susceptibility to type 1 diabetes . - pubmed
The E3 ubiquitin ligase Cbl - b regulates T cell activation thresholds and has been associated with protecting against type 1 diabetes , but its in vivo role in the process of self - tolerance has not been examined at the level of potentially autoaggressive CD4(+ ) T cells . - pubmed
Cblb deficiency subsequently precipitated diabetes in most TCR : insHEL animals by 15 wk of age . - pubmed
Reduction of plasma gelsolin levels correlates with development of multiple organ dysfunction syndrome and fatal outcome in burn patients . - pubmed
We hypothesized that the extent of pGSN reduction might correlate with different outcome of burn patients . - pubmed
The study was performed to evaluate the prognostic implications of pGSN levels on the development of multiple organ dysfunction syndrome ( MODS ) and fatal outcome in a group of severely burn patients . - pubmed
The results showed that pGSN concentrations , as well as the levels of IL-2 and IFN - gamma , decreased markedly on PBD 1 - 21 , whereas , the levels of IL-4 increased markedly in all burn groups as compared with normal controls ( P<0.05 or P<0.01 ) , and there were obviously differences between group I and group III ( P<0.05 or P<0.01 ) . - pubmed
Moreover , as the pGSN levels decreased , the incidence of septic complication as well as MODS remarkably increased . - pubmed
CONCLUSIONS : pGSN levels appear to be an early prognostic marker in patients suffering from major burns . - pubmed
[ Diagnostic significance of Th1 / Th2 cytokine pattern in childhood hemophagocytic lymphohistiocytosis ] . - pubmed
OBJECTIVE : To illustrate the diagnostic value of Th1 / Th2 cytokine pattern in childhood hemophagocytic lymphohistiocytosis ( HLH ) and its diagnostic accuracy . - pubmed
METHOD : The BD(TM ) CBA Human Th1 / Th2 Cytokine Kit II was used to measure the serum Th1 and Th2 cytokines , including Interferon - gamma ( IFN - gamma ) , tumor necrosis factor ( TNF ) , interleukin ( IL )- 10 , IL-6 , IL-4 and IL-2 in 50 patients with de novo HLH admitted to our hospital from Oct. 2005 to Aug. 2009 . - pubmed
The above cytokine levels were also determined in 250 healthy volunteers and 235 patients with sepsis as controls . - pubmed
The IFN - gamma , TNF , IL-10 , IL-6 , IL-4 and IL-2 levels for healthy children were ( 4.6 + - 1.8 ) ng / L , ( 4.0 + - 1.2 ) ng / L , ( 6.5 + - 1.3 ) ng / L , ( 6.0 + - 1.5 ) ng / L , ( 2.9 + - 0.8 ) ng / L and ( 2.6 + - 0.7 ) ng / L , while the median levels of them in acute phase of HLH children were 1138.5 ( 49.2 - 5000.0 ) ng / L , 3.4 ( 1.0 - 25.1 ) ng / L , 740.5 ( 26.5 - 5000.0 ) ng / L , 66.1 ( 3.9 - 4472.6 ) ng / L , 3.9 ( 1.0 - 32.8 ) ng / L and 4.0 ( 1.0 - 51.1 ) ng / L , respectively . - pubmed
IL-4 , IL-2 and TNF slightly elevated or at normal range in acute phase of HLH . - pubmed
The patients with sepsis showed a different cytokine pattern , with an extremely high level of IL-6 ( median : 251.3 ng / L , range : 8.4- & gt ; 5000.0 ng / L ) and moderately elevated level of IL-10 ( median : 46.5 ng / L , range : 3.1 - 5000.0 ng / L ) , whereas IFN - gamma was only slightly elevated ( median : 9.2 ng / L , range : 1.3 - 498.8 ng / L ) . - pubmed
When the criteria for HLH set as the following : IFN - gamma & gt ; 100 ng / L , IL-10 & gt ; 60 ng / L and the concentration of IFN - gamma higher than that of IL-6 , the specificity reached as high as 98.7 % and the sensitivity was 88.0 % for the diagnosis of HLH among patients with HLH and sepsis . - pubmed
CONCLUSION : The significant increase of IFN - gamma and IL-10 with slightly increased level of IL-6 is a sensitive and specific cytokine pattern for childhood HLH , which is helpful for its diagnosis and differential diagnosis . - pubmed
Common variants in the CD36 gene are associated with oral fat perception , fat preferences , and obesity in African Americans . - pubmed
The objective of this study was to determine whether human genetic variation in 5 common CD36 polymorphisms is associated with oral fat perception of Italian salad dressings , self - reported acceptance of high - fat foods and obesity in African - American adults ( n = 317 ) . - pubmed
RNA interference - mediated knockdown of SeP in the liver improved insulin resistance and hyperglycemia in type 2 diabetic mice , suggesting that SeP is a novel therapeutic target for type 2 diabetes . - pubmed
Mutational analysis of cutaneous squamous cell carcinomas and verrucal keratosis in patients taking BRAF inhibitors . - pubmed
B - RAF inhibitors ( BRAFi ) have been shown to improve rates of overall and progression - free survival in patients with stage IV metastatic melanoma positive for the BRAF V600E mutation . - pubmed
We have found upstream mutations in RAS as well as PIK3CA in both verrucal keratosis and cuSCC . - pubmed
Physical activity and risk of breast cancer overall and by hormone receptor status : the European prospective investigation into cancer and nutrition . - pubmed
However , whether this holds true for breast cancer subtypes defined by the estrogen receptor ( ER ) and the progesterone receptor ( PR ) status is controversial . - pubmed
Analyses by hormone receptor status suggested differential associations for total physical activity ( p - heterogeneity = 0.04 ) , with a somewhat stronger inverse relationship for ER+/PR+ breast tumors , primarily driven by PR+ tumors ( p - heterogeneity & lt ; 0.01 ) . - pubmed
Household physical activity was inversely associated with ER-/PR- tumors . - pubmed
Novel Autosomal Recessive c10orf2 Mutations Causing Infantile - Onset Spinocerebellar Ataxia . - pubmed
This genetically and phenotypically heterogeneous group includes infantile onset spinocerebellar ataxia ( OMIM # 271245 ) a neurodegenerative disease caused by mutations in the mtDNA helicase gene , c10orf2 , with an increased frequency in the Finnish population due to a founder mutation . - pubmed
We describe a child of English descent who presented with a severe phenotype of IOSCA as a result of two - novel mutations in the c10orf2 gene . - pubmed
Alternative alpha - synuclein transcript usage as a convergent mechanism in Parkinson ' s disease pathology . - pubmed
alpha - Synuclein is implicated both in physiological functions at neuronal synaptic terminals as well as in pathological processes in the context of Parkinson ' s disease . - pubmed
Common variants in the aSynL 3 ' untranslated region associated with Parkinson ' s disease risk promote the accumulation and translation of aSynL transcripts . - pubmed
We demonstrate that the presence of the extended aSynL transcript 3 ' untranslated region impacts accumulation of alpha - synuclein protein , which appears redirected away from synaptic terminals and towards mitochondria , reminiscent of Parkinson ' s disease pathology . - pubmed
Taken together , these findings identify a novel mechanism for aSyn regulation in the context of Parkinson ' s disease - associated genetic and environmental variations . - pubmed
About 10 % of all ALS cases are familial ; approximately 20 % of familial ALS cases are caused by mutations in the superoxide dismutase 1 ( SOD1 ) gene . - pubmed
We developed rats that express a human SOD1 transgene with ALS - associated mutations , developing striking motor neuron degeneration and paralysis . - pubmed
We administered human recombinant HGF ( hrHGF ) by continuous intrathecal delivery to the transgenic rats at the onset of paralysis for 4 weeks . - pubmed
To translate this strategy to human treatment , we induced a contusive cervical spinal cord injury in the common marmoset , a primate , and then administered hrHGF intrathecally . - pubmed
These results prompted further clinical trials in ALS using continuous intrathecal administration of hrHGF . - pubmed
While the down - regulated four genes , MAPK4 , FASN , INSIG1 and SCD , were mainly linked to the endoplasmic reticulum and fatty acid biosynthesis , these two cell processes that are associated with drug sensitivity by increasing evidences . - pubmed
Transforming growth factor - beta and epithelial - mesenchymal transition are associated with pulmonary metastasis in adenoid cystic carcinoma . - pubmed
MATERIALS AND METHODS : TGF - beta1 , phospho - Smad2 and beta - catenin expression in ACC tissues derived from patients was evaluated by immunohistochemistry . - pubmed
RESULTS : Overexpression of TGF - beta1 and phospho - Smad2 , and reduced expression of membrane beta - catenin , were closely associated with lung metastasis in ACC . - pubmed
Blockade of TGF - beta signaling by TbetaRIIDN or siRNA may offer potential gene therapies against pulmonary metastasis in patients with ACC . - pubmed
Glucose tolerance , insulin resistance , insulin secretory capacity , anthropometric measurements , lipid profiles , nutrient intakes and pregnancy outcomes were evaluated at 24 - 28 weeks of gestation . - pubmed
Participants with the greater adherence to the DASH diet were 54 , 73 , 78 , and 80 % less likely to have enlarged waist circumference , hyperglyceridemia , low HDL - C levels , and high blood pressure , respectively , compared with those in the lowest tertile . - pubmed
The sigma-2 receptors are promising therapeutic targets because of their significant upregulation in tumor cells compared with normal tissue . - pubmed
Adjustments of acute oral rat toxicity values by simulating fractional absorption and CYP - based metabolism as well as removing compounds with hydrolyzable linkages or flagged as substrates for glucuronidation delineated an upper boundary for rat oral toxicity versus MMP . - pubmed
CONCLUSION : CA - MRSA was the leading cause of BJI and was associated with higher CRP on admission , later normalization and longer treatment duration . - pubmed
Anti - Phospholipase A2 Receptor Antibody as Prognostic Indicator in Idiopathic Membranous Nephropathy . - pubmed
BACKGROUND : Anti - phospholipase A2 receptor antibody ( PLA2R - Ab ) is useful in diagnosing idiopathic membranous nephropathy ( IMN ) . - pubmed
We investigated the clinical relevance of PLA2R - Ab enzyme - linked immunosorbent assay ( ELISA ) in patients with IMN . - pubmed
METHODS : We measured PLA2R - Ab with an ELISA kit from the serum of 160 patients with IMN ( n = 93 ) , secondary MN ( n = 14 ) and other glomerulonephritis ( n = 41 ) as well as healthy controls ( n = 12 ) at the time of renal biopsy and investigated the correlation of titers of PLA2R - Ab with clinical parameters . - pubmed
RESULTS : PLA2R - Ab was positive in 41 of 93 patients ( 44.1 % ) with IMN . - pubmed
The PLA2R - Ab titer positively correlated with proteinuria and was negatively associated with renal function and serum albumin . - pubmed
CONCLUSION : The presence , as well as a high titer , of PLA2R - Ab on ELISA was associated with poor prognosis of IMN . - pubmed
Although endocrinologists and diabetes specialists will continue to maintain expertise in this field , it behooves the primary care physician to have a working knowledge of insulin pumps and sensors to ensure optimal clinical care and decision - making for their patients . - pubmed
Additionally , systemic therapy ( including steroids and calcineurin inhibitors ) may contribute to decreases in TFH cells in patients with cGVHD . - pubmed
Inhibition of CaMKII Attenuates Progressing Disruption of Ca ( 2 + ) Homeostasis Upon Left Ventricular Assist Device Implantation in Human Heart Failure . - pubmed
The fact that CaMKII inhibition reduces the SR - Ca ( 2 + ) leak in HF - Tx suggests that CaMKII inhibition may be a promising option to beneficially influence clinical course after LVAD implantation . - pubmed
This study sought to determine frequency , specificity and level of Ab to VAR2CSA produced in children and whether children with hyperparasitaemia and severe malaria are more likely to produce Ab to VAR2CSA compared to healthy children . - pubmed
METHODS : Antibody responses to a panel of recombinant proteins consisting of multiple VAR2CSA Duffy - binding - like domains ( DBL ) and full - length VAR2CSA ( FV2 ) were characterized in 193 1 - 15 year old children from rural Cameroonian villages and 160 children with severe malaria from the city . - pubmed
Children with severe forms of malaria had significantly higher IgG to merozoite antigens ( all p & lt ; 0.05 ) , but not to VAR2CSA ( all p & gt ; 0.05 ) when compared to the healthy children . - pubmed
CONCLUSION : The study suggests that children , including teenage girls acquire Ab to VAR2CSA domains and FV2 , but Ab levels are much lower than those needed to protect women from placental infections and repertoire of Ab responses to DBL domains is different from those in pregnant women . - pubmed
Interestingly , children with severe malaria did not have higher Ab levels to VAR2CSA compared to healthy children . - pubmed
Huntington ' s disease is a fatal autosomal genetic disorder characterized by an expanded glutamine - coding CAG repeat sequence in the huntingtin ( Htt ) exon 1 gene . - pubmed
PTEN , KRAS and PIK3R1 were the most frequently mutated canonical cancer - related genes . - pubmed
In a rat skin wound model , miR-149 improved the quality of the arrangement of collagen bundles and reduced inflammatory cell infiltration during skin wound healing . - pubmed
Pingyangmycin Pretreatment Influences the Biological Behavior of Ocular Venous Malformation and Relates with Galectin-3 Expression . - pubmed
BACKGROUND : Galectin-3 ( Gal-3 ) plays a role in the mechanisms underlying ocular venous malformation . - pubmed
We conducted this study to investigate the effect of pingyangmycin pretreatment on the Gal-3 expressions and biological behavior of ocular venous malformation . - pubmed
CONCLUSIONS : Gal-3 expression may be involved in the development and invasiveness of ocular venous malformation , and pingyangmycin can inhibit Gal-3 expression , indicating a role of pingyangmycin treatment before the removal of ocular venous malformation . - pubmed
Aspartate transaminase ( AST ) and alanine transaminase ( ALT ) increased continuously until the diagnosis of complication in both stricture and rejection groups with more rapid increase in enzymes in the rejection versus stricture group ( P & lt ; .05 ) . - pubmed
The increasing slope and final levels of AST and ALT are potentially helpful parameters to differentiate rejection and stricture , the 2 most common posttransplantation complications . - pubmed
Multivariate analysis showed T stage , N stage , insulinoma and Ki-67 index were independent predictors of recurrence ( P & lt ; 0.05 ) . - pubmed
Intracellular galectin-7 expression in cancer cells results from an autocrine transcriptional mechanism and endocytosis of extracellular galectin-7 . - pubmed
The beta - galactoside binding protein galectin-7 ( gal-7 ) is constitutively expressed at abnormally high levels in the outside milieu and intracellular compartments of many types of epithelial cancer cells , most notably in aggressive forms of ovarian and breast cancer . - pubmed
Taken together , these findings reveal the existence of a positive self - amplification pathway that regulates intracellular gal-7 expression in breast and ovarian cancer cells . - pubmed
TSSC6 KO mice treated with clopidogrel exhibited synergy in delayed kinetics of clot retraction , reduced collagen - mediated platelet aggregation , and platelet spreading on fibrinogen . - pubmed
Platelets derived from TSSC6 mice with P2Y12 blockade form smaller thrombi when perfused over a collagen matrix under arterial flow . - pubmed
Clopidogrel treated TSSC6 KO arterioles showed smaller and less stable thrombi with increased tendency to embolise in vivo . - pubmed
These studies demonstrate a complementary role between TSSC6 and P2Y12 receptor in platelets in regulating ' outside in ' integrin alphaIIbbeta3 signalling thrombus growth and stability . - pubmed
METHODS : The infants of insulin - dependent , pregestational diabetic mothers were identified in the daily review of the medical records of each newborn infant with a malformation and her / his mother 's medical record . - pubmed
In this review article , we made comprehensive literature survey emphasising on donepezil template which was structurally converted into plethora of MTLDs preserving anti - cholinesterase effect and , at the same time , escalating the anti - oxidant potential , which was reported as a crucial role in the pathogenesis of the Alzheimer ' s disease . - pubmed
Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2 / HO-1 Pathway . - pubmed
Taken together , our data for the first time confirmed the protective effects of ISL on AP in mice via inhibition of oxidative stress and modulation of the Nrf2 / HO-1 pathway . - pubmed
A Ketogenic Diet Reduces Central Obesity and Serum Insulin in Women with Ovarian or Endometrial Cancer . - pubmed
Objective : We hypothesized that a KD would improve body composition and lower serum insulin and insulin - like growth factor - I ( IGF - I ) in women with ovarian or endometrial cancer . - pubmed
Visceral fat mass and fasting serum insulin also are reduced by the KD , perhaps owing to enhanced insulin sensitivity . - pubmed
The angiotensin II / AT1 receptor pathway mediates malaria - induced acute kidney injury . - pubmed
Here , we investigated the potential role of the angiotensin II ( Ang II )/ AT1 receptor pathway in the development of MAKI . - pubmed
PbA - infected mice also presented proteinuria and a high level of urinary gamma - glutamyltransferase activity associated with an increase in collagen deposition and interstitial space , showing tubule - interstitial injury . - pubmed
Our data allow us to postulate that the Ang II / AT1 receptor pathway mediates an increase in renal pro - inflammatory cytokines , which in turn leads to the glomerular and tubular injuries observed in MAKI . - pubmed
It was shown that the mechanism of cell death caused by BRET - induced phototoxicity of mimiSOG in the presence of furimazine depends on the intracellular localization of the NanoLuc - miniSOG fusion protein : BRET - mediated activation of miniSOG in mitochondrial localization causes apoptosis , while the membrane localization of PS causes necrosis of cancer cells . - pubmed
Mevalonate - derived products are also essential for the Hedgehog pathway , steroid hormone signaling , and the nuclear localization of Yes - associated protein and transcriptional co - activator with PDZ - binding motif , all of which playing roles in tumorigenesis and cancer stem cell function . - pubmed
Clinical application of statins is marred by dose - limiting toxicities and mixed outcomes on cancer risk , survival and mortality , partially resulting from the statin - mediated compensatory upregulation of HMGCR and indiscriminate inhibition of HMGCR in normal and tumor cells . - pubmed
Tumor HMGCR is resistant to the sterol - mediated transcriptional control ; consequently , HMGCR is upregulated in cancers derived from adrenal gland , blood and lymph , brain , breast , colon , connective tissue , embryo , esophagus , liver , lung , ovary , pancreas , prostate , skin , and stomach . - pubmed
Nevertheless , tumor HMGCR remains sensitive to isoprenoid - mediated degradation . - pubmed
In this study , we report nuclear magnetic resonance ( NMR ) based metabolomic analysis of surgically resected tumors from forty five pituitary tumor patients [ gonadotropic ( LH / FSH - secreting ) = 17 ; prolactinomas ( PRL - secreting ) = 11 , Cushing ' s disease ( ACTH - secreting ) = 4 , non - functional = 5 , and mixed = 8 ] who underwent transsphenoidal selective adenomectomy . - pubmed
Compared to LH / FSH - secreting tumors , PRL - secreting tumors showed statistically significant decrease in the levels of N - acetylaspartate ( NAA ) , myo - inositol ( mI ) , scyllo - inositol ( sI ) , glycine , taurine , phosphoethanolamine ( PE ) and increase in the levels of glutamine . - pubmed
When compared with LH / FSH - secreting tumors , ACTH - secreting tumors showed statistically significant decrease in the levels of sI , glycine , PE and increase in the levels of aspartate . - pubmed
Although lipid extracts of PAs showed the presence of many common lipid molecules , only glycerophosphoethanolamine ( GPE ) showed statistically significant decrease in PRL , ACTH and non - functional subtypes when compared to LH / FSH - secreting tumors . - pubmed
Hydroxymethylene diphosphonate for imaging transthyretin cardiac amyloidosis . - pubmed
Future clinical and biochemical predictions of Fabry disease in females by methylation studies of the GLA gene . - pubmed
Fabry disease is an X - linked lysosomal storage disorder caused by a deficiency of alpha - galactosidase A ( alpha - gal A ) . - pubmed
We previously reported that one heterozygous Fabry female showing classical phenotypes had complete methylation of the non - mutated allele of the GLA gene . - pubmed
The mitochondrial transporter uncoupling protein 2 ( UCP2 ) controls cell proliferation in vitro through the modulation of cellular metabolism , but the underlying mechanism in tumors in vivo remains unexplored . - pubmed
Using murine intestinal cancer models and CRC patient samples , we find higher UCP2 protein levels in tumors compared to their non - tumoral counterparts . - pubmed
Mechanistically , UCP2 loss increases levels of oxidized glutathione and proteins in tumors . - pubmed
We show that UCP2 loss renders colon cells more prone to malignant transformation through metabolic reprogramming and perturbation of redox homeostasis and could favor worse outcomes in CRC . - pubmed
Metformin attenuates PD - L1 expression through activating Hippo signaling pathway in colorectal cancer cells . - pubmed
In colorectal carcinoma ( CRC ) , PD - L1 expression results in immune escape and poor prognosis . - pubmed
After silencing or inhibiting YAP1 expression by Verteporfin ( VP ) , the inhibitor of YAP1 , the expression of PD - L1 were decreased in protein level in CRC cells . - pubmed
Compared with the control group , PD - L1 and YAP1 expressions in tumor tissues , detected by immunohistochemistry , were reduced in the group of metformin treatment . - pubmed
These findings illuminate a new regulatory mechanism , metformin activates Hippo signaling pathway to regulate PD - L1 expression and suggests that metformin has the possibility to increase the efficacy of immunotherapy in human CRC . - pubmed
Erythropoietin Alleviates Burn - induced Muscle Wasting . - pubmed
We hypothesized EPO could attenuate burn - induced muscle fiber atrophy . - pubmed
Methods : Rats were allocated into four groups : a sham burn group , an untreated burn group subjected to third degree hind paw burn , and two burn groups treated with weekly or daily EPO for four weeks . - pubmed
Results : EPO attenuated the reduction of mean myofiber cross - sectional area post - burn and the level of the protective effect was no significant difference between two EPO - treated groups ( p=0.784 ) . - pubmed
Furthermore , EPO decreased the expression of atrophy - related ubiquitin ligase , atrogin-1 , which was up - regulated in response to burn . - pubmed
Compared to untreated burn rats , those receiving weekly or daily EPO groups had less cell apoptosis by TUNEL assay . - pubmed
EPO decreased the expression of cleaved caspase 3 ( key factor in the caspase - dependent pathway ) and apoptosis - inducing factor ( implicated in the caspase - independent pathway ) after burn . - pubmed
Furthermore , EPO alleviated connective tissue overproduction following burn via transforming growth factor beta 1 - Smad2 / 3 pathway . - pubmed
Daily EPO group caused significant erythrocytosis compared with untreated burn group but not weekly EPO group . - pubmed
Conclusion : EPO therapy attenuated skeletal muscle apoptosis and fibrosis at four weeks post - burn . - pubmed
Weekly EPO may be a safe and effective option in muscle wasting post - burn . - pubmed
Within the V - A ECMO group , there was no significant association between extreme hyperoxia and in - hospital mortality ( P = 0.19 ) , duration of mechanical ventilation ( P = 0.63 ) , or troponin levels ( P = 0.16 ) in the first 24 hrs . - pubmed
RESULTS : Advancing age , manufacturing profession , history of cerebrovascular disease , higher cardiovascular disease burden , diabetes , slower walking speed , higher number of medications , and the APOE epsilon4 allele were associated with accelerated odor identification decline ( ps < 0.014 ) . - pubmed
Efficacy and safety of a sodium - glucose co - transporter-2 inhibitor vs placebo as an add - on therapy for people with type 2 diabetes inadequately treated with metformin and a dipeptidyl peptidase-4 inhibitor : a systematic review and meta - analysis of randomized controlled trials . - pubmed
AIMS : To conduct a systematic review and meta - analysis to assess the efficacy , safety and tolerability of sodium - glucose co - transporter-2 inhibitors vs placebo as add - on therapy after metformin and dipeptidyl peptidase-4 inhibitor dual therapy in type 2 diabetes . - pubmed
Genital infections ( odds ratio 7.37 , 95 % CI 3.06 , 17.76 ; P < 0.00001 ) were more common with sodium - glucose co - transporter-2 inhibitors , but there was no significant statistical difference in urinary tract infections ( odds ratio 1.16 , 95 % CI 0.63 , 2.13 ; P=0.64 ) , in hypoglycaemia ( odds ratio 1.36 , 95 % CI 0.61 , 3.04 ; P = 0.45 ) , or in discontinuation rates due to adverse events ( odds ratio 1.52 , 95 % CI 0.78 , 2.97 ; P=0.22 ) between the two groups . - pubmed
CONCLUSIONS : In comparison with placebo , add - on therapy with a sodium - glucose co - transporter-2 inhibitor is significantly more efficacious in lowering HbA1c , fasting plasma glucose and weight in people with type 2 diabetes following inadequate glycaemic control with metformin and a dipeptidyl peptidase-4 inhibitor . - pubmed
Maternal Prenatal Depression in Pregnancies With Female and Male Fetuses and Developmental Associations With C - reactive Protein and Cortisol . - pubmed
Maternal C - reactive protein levels were significantly associated with depression only in pregnancies with male fetuses and with decreased newborn P50 inhibition only in male newborns . - pubmed
Maternal cortisol levels were significantly associated with depression only in pregnancies with female fetuses and with decreased newborn P50 inhibition only in female newborns . - pubmed
CONCLUSIONS : This study finds sex - specific associations of C - reactive protein and cortisol levels with prenatal depression in women and with decreased development of newborn P50 inhibition . - pubmed
Decreased newborn P50 inhibition is associated with later childhood behavioral problems , and decreased P50 inhibition is a pathophysiological feature of several mental illnesses . - pubmed
Novel allosteric PARP1 inhibitors for the treatment of BRCA - deficient leukemia . - pubmed
The successful use of PARP1 inhibitors like olaparib ( Loparza ) in the treatment of BRCA1 / 2 - deficient breast cancer has provided clinical proof of concept for applying personalized medicine based on synthetic lethality to the treatment of cancer . - pubmed
NMDAR antibody encephalitis overlapping with CLIPPERS syndrome in a psoriasis patient on adalimumab . - pubmed
alpha1 - Fetoprotein measurement in blood spotted on paper : discriminating test for hereditary tyrosinemia in neonatal mass screening . - pubmed
The comparative value of serum neutralization , hemadsorption inhibition and immunofluorescence reactions in the diagnosis of PI-3 and IBR viral infections of calves ] . - pubmed
Decreased fidelity of DNA polymerase activity during N-2 - fluorenylacetamide hepatocarcinogenesis . - pubmed
Performance of the mucinous - like carcinoma - associated antigen in serous effusions . - pubmed
The mucinous - like carcinoma - associated antigen ( MCA ) , a new tumour marker , was dosed in 150 serous effusions . - pubmed
Systemic lymphoblastoid interferon therapy in chronic progressive multiple sclerosis . - pubmed
Immunologic functions are studied in conjunction with a placebo - controlled trial of lymphoblastoid interferon ( IFN ) in patients with chronic progressive ( CP ) multiple sclerosis . - pubmed
Prior to treatment , CD4 + cells are significantly increased and CD8 + cells decreased in the blood of MS patients . - pubmed
Although these immune functions may identify a number of CP MS patients who might benefit from IFN , it is unlikely that these mechanisms actually mediate the potentially beneficial effects of this cytokine . - pubmed
Pneumococci and Haemophilus are still the two most prevalent pathogens in acute otitis media and raise problems regarding susceptibility : 25 % of Haemophilus beta - strains produce beta - lactamases and 6 to 12 % of pneumococci are intermediate or resistant to penicillin . - pubmed
The new oral third generation cephalosporins are effective in infections due to beta - lactamase - producing Haemophilus strains . - pubmed
The efficiency of an ELISA method , designed to detect polyvalent IgG and IgM antibodies to Salmonella typhi polysaccharide was evaluated in patients admitted or convalescing from typhoid fever and in control subjects . - pubmed
These results and additional immunoblotting tests suggest that ELISA developed to detect polyvalent anti - LPS antibodies could represent a highly specific diagnostic tool to confirm typhoid fever in endemic areas . - pubmed
Effects of late administration of tissue - type plasminogen activator on left ventricular remodeling and function after myocardial infarction . - pubmed
The beneficial effect of late thrombolysis with rt - PA may be related to a reduction in myocardial expansion and thus to a favorable influence on postinfarction left ventricular remodeling . - pubmed
Expression of transforming growth factor alpha in human gliomas . - pubmed
Expression of transforming growth factor alpha ( TGF alpha ) is frequently associated with the development of human and animal tumors . - pubmed
Using a sensitive immunohistochemical assay , which can be applied on formalin - fixed , paraffin - embedded tissue , we have examined the expression of TGF alpha in 71 human gliomas ( 63 untreated and 8 recurrent tumors ) . - pubmed
A strong positive correlation between tumor grade and extent of TGF alpha expression was found ( P less than 0.0001 ) . - pubmed
Similarly , using TNF - specific antibody reagents , TNF - secreting cells were detected and quantitated in cell populations obtained from normal lymphoid tissues , bone marrow and peripheral blood , following activation with phorbol myristate acetate and ionomycin . - pubmed
Elevated serum lactate dehydrogenase occurred mainly in IG and HG lymphomas and was an important prognostic factor . - pubmed
The action of opiate receptor agonists : ( D - Ala2 )- methionine enkephalinamide ( D - MEA ) , morphine , heroin , etorphine , and antagonists : naloxone and diprenorphine on audiogenic seizures was tested during ethanol abstinence . - pubmed
This mechanism is quantifiable by the plasma renin level or the hypotensive response to an antirenin - system drug ( converting enzyme inhibitor , beta blocker or saralasin ) . - pubmed
The lateral diffusion of lectin - labelled glycoconjugates was studied in the human colon carcinoma cell line HT29 using fluorescence photobleaching techniques . - pubmed
The circadian variation of thyrotrophin in patients with primary thyroidal disease . - pubmed
It was found that some patients with hyperthyroidism and suppressed basal TSH levels exhibited a 24 h secretory pattern similar to that seen in normal subjects with peak TSH levels occurring at night . - pubmed
In addition two subjects with a euthyroid multinodular goitre demonstrated levels of TSH below the normal range despite being clinically and biochemically euthyroid . - pubmed
TSH suppression in these subjects is probably related to some degree of thyroid autonomy and possible development of hyperthyroidism in the future . - pubmed
Uptake of a monoclonal antibody against CEA ( Tumak 431/31 ) in a human colon tumor ( Co-112 ) xenografted in the nude mouse . - pubmed
A monoclonal antibody ( Tumak ) against carcinoembryonic antigen ( CEA ) was injected into nude mice bearing a human colon carcinoma ( Co-112 ) . - pubmed
To this end , the metabolic fates of a small protein , lambda - L chain ( mol wt 44,000 ) , and a protein of intermediate size , IgG ( mol wt 160,000 ) , were studied in controls and patients with renal disease . - pubmed
Patients with renal tubular disease had a 50 - fold increase in the daily urinary excretion of 15 - 40,000 molecular weight proteins such as lysozyme and lambda - L chains . - pubmed
Serum IgG and lambda - L chain survivals were normal ; however , the fraction of the over - all lambda - L chain metabolism accounted for by proteinuria was increased 40 - fold whereas endogenous catabolism was correspondingly decreased . - pubmed
Patients with the nephrotic syndrome had a slight increase in lambda - L chain survival whereas IgG survival was decreased and the fraction of IgG lost in the urine was markedly increased . - pubmed
Patients with uremia had a normal IgG survival but a four to 10 - fold prolongation of lambda - L chain survival due to loss of entire nephrons , the major site of metabolism of these proteins . - pubmed
This results in an increase ( up to 10 - fold ) in the serum concentration of lambda - L chain , lysozyme , and other small biologically active proteins , a phenomenon that may be of importance in causing some of the manifestations of the uremic syndrome . - pubmed
[ Evaluation of circulating immune complexes in leprosy in relation to clinical activity , antileprosy agents , bacterial indices and anti - DNA antibodies ] . - pubmed
[ Limits of insulin therapy in type II diabetes ] . - pubmed
Human dopamine - beta - hydroxylase : comparison of the enzyme from plasma , adrenal medulla , and pheochromocytoma by radioimmunoassay . - pubmed
Low - dose aspirin does not prevent thrombovascular accidents in low - risk haemodialysis patients during treatment with recombinant human erythropoietin . - pubmed
Treatment of the anaemia of renal disease with recombinant human erythropoietin results in an improvement of haemostasis and an increased risk of thrombovascular accidents . - pubmed
In this prospective , placebo - controlled , double - blind , and cross - over study , the effects of low - dose acetylsalicylic acid ( 30 mg daily ) on thrombotic and bleeding events during the initial period of treatment with erythropoietin in anaemic haemodialysis patients without previous thrombovascular accidents or known increased risk for thrombosis were investigated . - pubmed
In conclusion , erythropoietin treatment resulted in a reduction of the bleeding time . - pubmed
Distal accentuation of conduction slowing in polyneuropathy associated with antibodies to myelin - associated glycoprotein and sulphated glucuronyl paragloboside . - pubmed
In four patients with a chronic , demyelinating polyneuropathy associated with monoclonal IgM antibodies to myelin - associated glycoprotein ( MAG ) and sulphated glucuronyl paragloboside ( SGPG ) , we have observed a marked prolongation of distal motor latencies disproportionate to proximal segment - conduction velocities , in nearly all nerves studied . - pubmed
Sixteen of 21 nerves ( 76 % ) studied in the patients with anti - MAG / SGPG polyneuropathy had a terminal latency index of & lt ; or = 0.25 versus 11 of 195 nerves ( 6 % ) of Charcot - Marie - Tooth polyneuropathy type 1A patients , three of 49 nerves ( 6 % ) of patients with chronic inflammatory polyneuropathy and none of the controls ( P = 0.0001 ) . - pubmed
Recognition of this unique pattern of generalized , distally predominant conduction slowing in anti - MAG / SGPG polyneuropathy may be useful in clinically distinguishing this from other chronic demyelinating polyneuropathies , and in possibly providing insights into the pathophysiology of this disorder . - pubmed
In addition , analysis of the restriction maps of T cell receptor ( TRC )- beta , demonstrated that an oligoclonal population of T cells was preselected in vivo , near the tumour site , and might be expanded in vivo , using phytohaemagglutin and interleukin 2 while maintaining the same characteristics of the original population . - pubmed
Remission maintenance therapy with histamine and interleukin-2 in acute myelogenous leukaemia . - pubmed
The IL-2 - induced killing of AML blasts was inhibited by monocytes , recovered from peripheral blood by centrifugal elutriation . - pubmed
Histamine , of concentrations within the micromolar range , abrogated the monocyte - induced inhibition of NK - cells ; thereby , histamine and IL-2 synergistically induced NK - cell - mediated killing of AML blasts . - pubmed
Based on these in vitro findings , seven patients with AML in first ( n=2 ) , second ( n=3 ) or third ( n=2 ) complete remission ( CR ) were given home therapy with interleukin-2 ( IL-2 ; O.9 x 10(6 ) IU x 2 s.c . ) - pubmed
Toxicity was moderate and include local reactions to IL-2 at the site of injection and short - lasting flush , hypotension , and headache to histamine . - pubmed
We conclude that ( i ) histamine and IL-2 synergize to kill human AML blasts in vitro , and ( ii ) histamine / IL-2 is a safe and feasible approach to immunotherapy of AML which merits further investigation . - pubmed
A colorimetric immunoassay for the detection of E - cadherin and carcinoembryonic antigen ( CEA ) expression on human colon carcinoma cell lines in vitro . - pubmed
An immunohistochemical assay , using 96 - well microtiter plates and based on the avidin - biotin peroxidase reaction , was developed for the quantitation of E - cadherin and CEA expression on HT-29 and SW620 colon carcinoma cells . - pubmed
Collagen and glycosaminoglycans of Wharton ' s jelly and their alterations in EPH - gestosis . - pubmed
For these reasons the role of collagen and glycos - aminoglycans ( GAGs ) of UC in pathobiochemistry of this syndrome seems to be important . - pubmed
We studied histology of extracellular matrix components , quantity , solubility and molecular polymorphism of collagen , proportional relationships between various types of collagen , the amounts of GAGs and proportional relationships between them in Wharton 's jelly of control newborns delivered by healthy mothers and those delivered by mothers with EPH - gestosis . - pubmed
Acute effects of bromocriptine , cyproheptadine , and valproic acid on plasma adrenocorticotropin secretion in Nelson ' s syndrome . - pubmed
Previous studies have found that bromocriptine , cyproheptadine , and valproic acid can reduce ACTH secretion in Nelson ' s syndrome , but none of these agents has achieved widespread use due to their failure to normalize ACTH in most patients . - pubmed
We conclude that at the doses studied , bromocriptine had the greatest acute effect in suppressing ACTH secretion in Nelson ' s syndrome , and that combined administration with valproic acid and cyproheptadine did not further increase this acute ACTH - suppressive effect . - pubmed
Prenatal diagnosis of carbamoyl phosphate synthetase I deficiency by identification of a missense mutation in CPS1 . - pubmed
Potential drugs against cervical cancer : zinc - ejecting inhibitors of the human papillomavirus type 16 E6 oncoprotein . - pubmed
Current therapeutic strategies aim at the inhibition of activation of platelets and the coagulation cascade and the suppression of platelet aggregation and fibrin formation . - pubmed
Figure 2 shows the mechanism of action of the GP - IIb / IIIa blockers on platelet aggregation . - pubmed
The aetiological agent of prion disease is proposed to be an aberrant isoform of the cell surface glycoprotein known as the prion protein ( PrP ( c ) ) . - pubmed
Neurodegeneration in these disease has been shown to be associated with accumulation of PrP(Sc ) in affected tissue . - pubmed
To investigate the possible uptake mechanisms that may be required for PrP(Sc)-induced neurodegeneration we studied the cellular trafficking of the neurotoxic fragment , PrP106 - 126 . - pubmed
The data obtained suggest that the fatal changes in brain tissue associated with the prion diseases , are initiated by a conformational rearrangement of constitutively expressed cellular protein PrP. - pubmed
A pharmacokinetic study of cyanamide , an inhibitor of aldehyde dehydrogenase ( EC1.2.1.3 ) used as an adjuvant in the aversive therapy of chronic alcoholism , has been carried out in healthy male volunteers following intravenous and oral administration . - pubmed
The results obtained imply that genetic alterations that both impair p53 function and deregulate E2F-1 expression may render hematopoietic cells refractory to the induction of differentiation and are , thereby , likely to play a major role in the progression of leukemias . - pubmed
The role of beta - amyloid ( Abeta ) in neuron dysfunction in the initiation stage may be mediated through alterations in signal transduction pathways involving cyclic AMP response element binding protein ( CREB ) . - pubmed
METHOD : In a group of 25 type 1 diabetics selected at random ( 12 women and 13 men ) , mean age 40.5 years + /- 11.6 SD ( range 21 to 57 years ) with a duration of diabetes of 17.8 + /- 7.9 years ( minimum 4 , maximum 35 years ) with a mean value of glycosylated haemoglobin of 8.71 % + /- 1.82 ( minimum 7.2 , maximum 12.2 % ) the authors assessed : the time of gastric emptying by scintigraphic follow up of the progress of solid food ( rice labelled with 99mTc ) . - pubmed
The correlation of gastric emptying and time factors ( age , duration of diabetes ) and metabolic factors ( blood sugar level , glycosylated haemoglobin ) . - pubmed
The level of CRP is related to the level of albumin , suggesting that inflammation is related to nutritional status . - pubmed
The level of homocysteine is associated with the level of von Willbrand factor , suggesting that homocysteine is related to endothelial injury . - pubmed
Study of the BtK gene enabled differential diagnosis with common variable immunodeficiency disease in some patients who showed absent or very low lymphocyte B counts as well as forms of autosomal recessive agammaglobulinemia . - pubmed
Using the same techniques , we were able to identify mutations in the CD40 ligand gene in three families in which one of the members had clinical and biological phenotype compatible with X - linked hyper - IgM. - pubmed
Tumour necrosis factor microsatellites and HLA - DRB1 * , HLA - DQA1 * , and HLA - DQB1 * alleles in Peruvian patients with rheumatoid arthritis . - pubmed
OBJECTIVE : To study the association between rheumatoid arthritis ( RA ) and HLA and tumour necrosis factor ( TNF ) polymorphism in Peruvian mestizo patients in comparison with ethnically similar controls . - pubmed
METHODS : Seventy nine patients with RA and 65 ethnically matched healthy controls were genotyped for HLA - DRB1 , HLA - DQA1 , HLA - DQB1 , and TNFalpha and TNFbeta alleles using PCR amplification . - pubmed
CONCLUSIONS : This study shows for the first time that TNF gene polymorphism is associated with susceptibility to RA in a non - white population . - pubmed
We and others reported increased abundance of catalytically impaired PTP-1B in tissue lysates from obese human subjects with and without type 2 diabetes , while genetic knockout of PTP-1B improves insulin sensitivity and prevents nutritionally mediated insulin resistance and obesity . - pubmed
Ad5 treatment did not result in a statistically or clinically significant liver injury , as determined by serum alanine aminotransferase and histological examination . - pubmed
Seven days post injection , no significant difference in rate of weight gain , fasting blood glucose or insulin levels were seen in any group . - pubmed
A glutamate residue at the C terminus regulates activity of inward rectifier K + channels : implication for Andersen ' s syndrome . - pubmed
Expression and distribution of pituitary adenylate cyclase - activating peptide in human prostate and prostate cancer tissues . - pubmed
The presence , expression and distribution of pituitary adenylate cyclase - activating peptide ( PACAP ) in human prostate cancer and healthy tissue were investigated by means of biochemical and morphological procedures . - pubmed
Immunohistochemistry on tissue sections indicated the location of PACAP in the epithelial layer of prostate glands ( and in some scarce leucocytes ) but not in the stroma , either in normal or carcinomatous tissues . - pubmed
These results are the first demonstration of the localization of PACAP or its precursors and its mRNA in the human prostate gland and their presence during the progression of prostate carcinoma . - pubmed
Inhibition of in vivo constriction of fetal ductus arteriosus by endothelin receptor blockade in rats . - pubmed
Dual ET receptor antagonist ( bosentan ) and selective ET - A blocker ( CI-1020 ) prevent constriction of the fetal ductus arteriosus induced by ductus - constricting agents in rats , indicating that ET and ET - A receptors are essential in fetal ductal constriction . - pubmed
[ Activated serine / threonine kinase AKT enhances the radioresistancy in human cholangiocarcinoma ] . - pubmed
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ( CADASIL ) is an angiopathy caused by mutations in the NOTCH3 gene . - pubmed
We analyzed these data to determine whether myocardial ischemia is associated with NOTCH3 mutations . - pubmed
To our knowledge , this is the first study showing that NOTCH3 mutation carriers may be at increased risk of early acute myocardial infarction , expanding CADASIL disease expression beyond the central nervous system to include the heart . - pubmed
Reduced fibrinolytic activity of atherosclerotic sera caused by an increase in low - density lipoproteins in blood . - pubmed
Enhanced expression of interleukin-8 and activation of nuclear factor kappa - B in endoscopy - negative gastroesophageal reflux disease . - pubmed
Recent studies have shown that IL-8 is likely involved in the development and progression of erosive reflux esophagitis ( RE ) , yet little is known about its implication in endoscopy - negative gastroesophageal reflux disease ( GERD ) . - pubmed
The purpose of this study was to determine IL-8 messenger ribonucleic acid ( mRNA ) expression levels in endoscopy - negative GERD , along with assessment of nuclear factor kappaB ( NF - kappaB ) activation , which upregulates IL-8 expression . - pubmed
In nine endoscopy - negative GERD patients , the IL-8 mRNA expression levels were measured before and 8 wk after treatment with lansoprazole . - pubmed
RESULTS : The relative IL-8 mRNA expression levels were significantly higher in esophageal mucosa of patients with endoscopy - negative GERD than those of the controls . - pubmed
The presence of basal zone hyperplasia and intraepithelial neutrophils , histopathological hallmarks of GERD , were associated with higher levels of IL-8 mRNA . - pubmed
The esophageal epithelium of patients with GERD showed intense immunoreactivity for IL-8 , and expressed CXCR-1 antigen . - pubmed
We found NF - kappaB activation in esophageal mucosa in GERD patients and the NF - kappaB subunits were localized predominantly in the nuclei of IL-8 - expressing cells . - pubmed
CONCLUSIONS : Our results demonstrate enhanced mucosal expression of IL-8 in incipient GERD even without mucosal breaks . - pubmed
NF - kappaB activation may be implicated in the pathogenesis in GERD . - pubmed
Intravenous leiomyomatosis of the uterus : a GnRH agonist utilisation before surgery . - pubmed
A synonymous coding polymorphism in the alpha2 - Heremans - schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians . - pubmed
The AHSG gene , consisting of seven exons and spanning 8.2 kb of genomic DNA , is located at chromosome 3q27 , a susceptibility locus for type 2 diabetes and the metabolic syndrome . - pubmed
These observations suggested that the AHSG gene is a strong positional and biological candidate for type 2 diabetes susceptibility . - pubmed
We carried out a detailed genetic association study of the contribution of these common AHSG SNPs to genetic susceptibility of type 2 diabetes in French Caucasians . - pubmed
Crosstalk of beta - adrenergic receptor subtypes through Gi blunts beta - adrenergic stimulation of L - type Ca2 + channels in canine heart failure . - pubmed
The mechanisms underlying the blunted contractile response to beta - adrenergic receptor ( beta - AR ) stimulation in heart failure ( HF ) are incompletely understood , especially with regard to beta - AR subtype - specific regulation of L - type Ca2 + channels . - pubmed
We evaluated the impact of HF induced by pacing tachycardia on beta - AR regulation of L - type Ca2 + channels in a canine model . - pubmed
Experiments testing beta1 - AR- and beta2 - AR - selective stimulation showed that the major component of the blunted response to nonselective beta - AR stimulation in HF was caused by beta2 - AR activation , resulting in a pertussis toxin - sensitive , Gi - mediated inhibition of the beta1 - AR - induced increase in I(Ca , L ) . - pubmed
In conclusion , canine HF results in the following : ( 1 ) a uniform reduction in beta1 - AR density in surface and T - tubule membrane fractions without a change in beta2 - AR density ; and ( 2 ) the emergence of distinct Gi - coupling to beta2 - ARs resulting in accentuated antagonism of beta1 - AR - mediated stimulation of I ( Ca , L ) . - pubmed
These results have implications for optimizing the use of beta - AR drugs in HF . - pubmed
G - CSF stimulated islands of haematopoiesis mimicking disseminated malignancy on PET - CT and MRI scans in a patient with hypoplastic marrow disorder . - pubmed
Our study suggests that the same quantitative trait locus on the chromosome 4 q region , where ADH3 is located , may influence the risk of alcoholism , variations of electroencephalogram , and the 4 ttdts of the event - related potential measures . - pubmed
[ From the Cochrane Library and Diabetes Care : self - monitoring of blood glucose probably an effective way to improve glycaemic control in patients with type 2 diabetes not taking insulin ] . - pubmed
Self - monitoring of blood glucose has been found to be effective for patients with type I diabetes and for patients with type 2 diabetes taking insulin . - pubmed
There is much debate on the effectiveness of self - monitoring of blood glucose in the management of patients with type 2 diabetes who are not taking insulin . - pubmed
A systematic review of 6 randomised controlled trials comparing self - monitoring of blood glucose with standard care , self - monitoring of urine glucose , or both showed that self - monitoring of blood glucose may be effective in improving glycaemic control in patients with type 2 diabetes who are not using insulin . - pubmed
Bacillus anthracis edema toxin ( ET ) , composed of protective antigen and an adenylate cyclase edema factor ( EF ) , elicits edema in host tissues , but the target cells and events leading from EF - mediated cyclic - AMP production to edema are unknown . - pubmed
Although the effects of pyrilamine , cromolyn , or aprepitant on ET - induced vascular leakage suggest a possible role for mast cells ( MC ) and sensory neurons in ET - induced edema , ET did not elicit degranulation of human skin MC or substance P release from NT2N cells in vitro . - pubmed
Endothelin 1 ( ET-1 ) produced abundantly by prostate cancer cells binds to its receptor present on bone marrow stromal cells and favors osteoblastic response during bone metastases of prostate cancer . - pubmed
This suggests that interrupting ET-1 interaction with its endothelin A ( ET ( A ) ) receptor could be useful for inhibiting prostate cancer bone metastasis and , as such , may enhance the therapeutic activity of docetaxel ( Taxotere ) , the most commonly used drug for the treatment of metastatic prostate cancer . - pubmed
Therefore , the goal of our study was to obtain preclinical data supporting our hypothesis that the combined use of ET ( A ) receptor antagonist ( ABT-627 ; Atrasentan ) with Taxotere will be superior in inducing apoptosis in vitro and inhibiting tumor growth in vivo in a SCID - hu model of experimental bone metastasis induced by C4 - 2b prostate cancer cells . - pubmed
In vitro studies were done on a panel of prostate cancer cell lines to understand the molecular basis of combination therapy , and we found that the combination was more effective in the inhibition of cell viability and induction of apoptosis in LNCaP and C4 - 2b cells ( androgen receptor positive ) but not in PC-3 cells . - pubmed
Tumor volume and serum prostate - specific antigen were used as terminal index to evaluate the therapeutic advantage of combination therapy relative to a single regimen and untreated control . - pubmed
[ Intrapleural streptokinase in the treatment of complicated parapneumonic empyema ] . - pubmed
As the benefit of the new antiretroviral drug class of the CCR5 coreceptor antagonists will be probably limited to the HIV - infected patients harbouring R5 strains , determination of viral coreceptor tropism has become an important diagnostic prerequisite for the treatment of HIV infection . - pubmed
In the event of intrauterine infection , lipoxygenase ( LOX ) metabolites are produced in the placenta and contribute to preterm labor and adverse fetal outcomes . - pubmed
Variable phenotype including Leigh syndrome with a 9185T>C mutation in the MTATP6 gene . - pubmed
Following recent reports of this same mutation in a single case and in a family with late - onset LS and NARP - like features , our paper emphasises the role of MTATP6 in LS and expands the associated clinical phenotype further . - pubmed
Syndecan-1 expression in gallbladder cancer and its prognostic significance . - pubmed
AIM : To determine whether the immunohistochemical detection of syndecan-1 could provide useful information as a novel therapeutic or prognostic factor in primary gallbladder ( GB ) cancer . - pubmed
MATERIALS AND METHODS : Forty - three GB cancer tissues were evaluated by immunohistochemistry for syndecan-1 expression . - pubmed
RESULTS : Epithelial syndecan-1 immunoreactivity was observed in 25 ( 58.1 % ) of the 43 GB cancer cases . - pubmed
The tumors with a positive syndecan-1 expression more frequently showed lymph node metastasis ( p = 0.037 ) . - pubmed
Although there was no statistically significant association , the tumors with a positive syndecan-1 expression tended to show a deeper invasion depth ( p = 0.087 ) and more frequent lymphovascular invasion ( p = 0.064 ) . - pubmed
CONCLUSIONS : A subset of GB cancers revealed an epithelial overexpression of syndecan-1 , which was associated with a progressive pathological feature and an aggressive clinical course . - pubmed
Therefore , epithelial syndecan-1 expression may be a predictor for a poor prognosis in patients with GB cancer . - pubmed
Aprepitan , a neurokinin-1 receptor antagonist , is a centrally active agent that might have the ability to decrease hot flashes . - pubmed
This study suggests that neurokinin receptors do not play a major role in mediating hot flashes . - pubmed
The partial dopamine D ( 2 ) receptor agonist aripiprazole has recently been tested as a treatment for stimulant and alcohol dependence in both animal and clinical studies . - pubmed
Interferon - gamma release assays do not identify more children with active tuberculosis than the tuberculin skin test . - pubmed
A negative interferon - gamma release assay should not dissuade paediatricians from diagnosing and treating presumed active tuberculosis . - pubmed
If used for diagnosis of latent tuberculosis infection , interferon - gamma release assays could significantly reduce the numbers of children receiving chemoprophylaxis . - pubmed
aureus ( MRSA ) isolates from device - related infections with both fnbA and fnbB produced significantly more biofilm than isolates with either gene alone . - pubmed
Under mildly acidic growth conditions , FnBP - mediated biofilm and fnbA and fnbB transcript levels were substantially higher during growth at 37 degrees C than at 30 degrees C. Thus , in addition to a lowered pH , carriage of both fnbA and fnbB and growth at 37 degrees C promote MRSA biofilm development , further supporting a role for the FnBPA and FnBPB surface proteins in the pathogenesis of MRSA device - related infections . - pubmed
Similar to the results for HMVEC - d cells , KSHV infection of HUVEC cells also resulted in an initial high level and subsequent decline in the expression of the lytic switch gene , ORF50 , while latent gene expression persisted . - pubmed
Interestingly , MPs from ischemic muscles produced more reactive oxygen species and expressed significantly higher levels of NADPH oxidase p47 ( 6 - fold ; P<0.05 ) and p67 subunits ( 16 - fold ; P<0.001 ) than controls , whereas gp91 subunit expression was unchanged . - pubmed
The present study is the first to evaluate the expression and activity of MnSOD , Cu / ZnSOD and catalase in human gastric samples , since ROS play a significant role in the pathogenesis of different forms of malignancy inducing mutations and various diseases such as gastric cancer . - pubmed
We found that MnSOD activity was increased in adenocarcinoma , CG and HP tissues ( p<0.05 - 0.001 ) , while Cu / ZnSOD was significantly lower in adenocarcinoma and HP tissues ( p<0.001 ) when compared to the healthy control . - pubmed
MnSOD and Cu / ZnSOD were expressed to a significantly higher degree in adenocarcinoma and HP tissues ( p<0.05 and & lt;0.001 respectively ) and to a significantly lower degree in CG tissues with respect to the healthy patients ( p<0.05 and & lt;0.001 ) . - pubmed
A significant decrease in CAT activity in adenocarcinoma and HP tissues was observed ( p<0.01 and & lt;0.05 ) . - pubmed
However , immunohistochemistry ( IHC ) showed the tumor cells to stain positively for cytokeratin 20 , but not for cytokeratin 7 , thus confirming the metastatic nature of the lesion . - pubmed
No clear evidence for an association between GH replacement and relapse of intracranial germ cell tumours : single centre and KIMS experience . - pubmed
Echinococcus multilocularis infection and TNF inhibitor treatment in a patient with rheumatoid arthritis . - pubmed
Adequate carbohydrate replacement before , during , and after exercise and reduction of preprandial rapid - acting insulin doses are the main allies in avoiding severe hypoglycemic events among diabetic children and adolescents . - pubmed
OBJECTIVE : Bone morphogenetic proteins ( BMPs ) play important roles in the stimulation of osteogenesis and osteoinduction during bone fracture healing and their expression levels may be important for bone graft efficacy . - pubmed
Negative pressure wound therapy overlay technique with collagen dressings for nonhealing wounds . - pubmed
BACKGROUND : Our clinical experience suggests that the effectiveness of negative pressure wound therapy is enhanced by adding collagen alginate to the dressing regimen , applying foam over areas that are undermined or tunneled , and approximating and securing wound edges prior to applying foam . - pubmed
CONCLUSION : Our outcomes demonstrate the feasibility of this technique and suggest that patients with significant wound size benefit from adding collagen alginate to negative pressure wound therapy and by applying foam over areas that are undermined or tunneled and/or approximating and securing wound edges prior to applying foam . - pubmed
VEGFR1 expression is related to lymph node metastasis and serum VEGF may be a marker of progression in the follow - up of patients with differentiated thyroid carcinoma . - pubmed
The aim of the study was to examine the expressions and serum levels of VEGF , VEGFR1 , IGF1 , and IGF1 receptor ( IGF1R ) in patients with differentiated thyroid carcinoma ( DTC ) compared with patients with nodular goiter ( NG ) . - pubmed
RESULTS : The immunostainings scores for VEGF , VEGFR1 , IGF1 , and IGF1R were found to be higher in patients with DTC than in those with NG . - pubmed
Serum VEGF was found to be higher in patients with progressive DTC than in patients in clinical remission . - pubmed
Increased serum levels of VEGF may reflect disease recurrence in DTC . - pubmed
It has been suggested that initial collagen contraction and thermal damage modulate wound healing . - pubmed
Microsomal epoxide hydroxylase genotypes / diplotypes , traffic air pollution , and childhood asthma . - pubmed
We investigated the associations of EPHX1 Tyr113His and His139Arg polymorphisms with asthma and wheezing outcomes , and focused on the functional genetic change in different ambient nitrogen dioxide ( NO2 ) levels on glutathione S - transferase p1 ( GSTP1 ) and glutathione S - transferase m1 ( GSTM1 ) genotypes . - pubmed
We examined the associations of EPHX1 Tyr113His and His139Arg genotypes and diplotypes with asthma and wheezing outcomes under different ambient NO2 exposures . - pubmed
RESULTS : Children with the EPHX1 Arg / His or Arg / Arg genotypes at codon 139 were significantly associated with increased risks of lifetime asthma ( adjusted OR [ aOR ] = 1.3 ; 95 % CI , 1.1 - 1.7 ; and aOR = 1.5 ; 95 % CI , 1.1 - 2.1 , respectively ) . - pubmed
The EPHX1 diplotypes showed significant associations with lifetime asthma ( global P value = .01 ) and early - onset asthma ( global P value = .01 ) . - pubmed
CONCLUSIONS : Children with high EPHX1 activity may have increase risk of asthma and wheezing outcomes , and can be mediated through airway oxidative stress generation . - pubmed
Endothelial cell - specific deficiency of Ang II type 1a receptors attenuates Ang II - induced ascending aortic aneurysms in LDL receptor-/- mice . - pubmed
RATIONALE : Human studies and mouse models have provided evidence for angiotensin II ( Ang II)-based mechanisms as an underlying cause of aneurysms localized to the ascending aorta . - pubmed
OBJECTIVE : The aim of this study was to define the role of angiotensin II type 1a ( AT ( 1a ) ) receptors and their cellular location in Ang II - induced ascending aortic aneurysms ( AAs ) . - pubmed
CONCLUSIONS : Ang II infusion promotes aneurysms in the ascending aorta via stimulation of AT ( 1a ) receptors that are expressed on endothelial cells . - pubmed
RANKL expression is related to treatment outcome of patients with localized , high - grade osteosarcoma . - pubmed
BACKGROUND : The receptor activator of nuclear factor kappaB ligand ( RANKL / TNFSF11 ) is expressed in metastatic bone cancer cells and has been suggested to play a key role in cell migration and metastatic behavior . - pubmed
We determined whether RANKL expression is correlated to clinical behavior of localized , high - grade osteosarcoma . - pubmed
RANKL expression and RANKL scores were not related to age , sex , tumor location , tumor volume , or pathologic subtype . - pubmed
CONCLUSIONS : The RANKL - RANK - OPG axis might be a promising target for the treatment of osteosarcoma , but further studies are needed to verify our data in a larger cohort . - pubmed
The effects of DISC1 risk variants on brain activation in controls , patients with bipolar disorder and patients with schizophrenia . - pubmed
Three risk variants ( rs1538979 , rs821577 , and rs821633 ) in the Disrupted - in - Schizophrenia-1 ( DISC1 ) gene have previously been associated with both schizophrenia and bipolar disorder in a recent collaborative analysis of European cohorts . - pubmed
These findings may provide a better understanding of the neural effects of DISC1 variants and on the pathophysiology of schizophrenia and bipolar disorder . - pubmed
In the present study , we showed that MAP1S levels immediately become elevated in response to diethylnitrosamine - induced or genome instability - driven metabolic stress in a murine model of hepatocarcinoma . - pubmed
We , therefore , conclude that an increase in MAP1S levels triggers autophagy to suppress genome instability such that both the incidence of diethylnitrosamine - induced hepatocarcinogenesis and malignant progression are suppressed . - pubmed
IPA - ranked signaling networks identified altered p21 , EF1alpha , Akt , MAPK , and NF - kappaB signaling networks promoting genetic disorder , altered cell cycle , cancer and changes in nucleic acid and energy metabolism . - pubmed
In Drosophila melanogaster , mutations in the gene drop - dead ( drd ) result in early adult lethality , with flies dying within 2 weeks of eclosion . - pubmed
Lipid peroxidation and spectrin of RBC membrane in hydroxyurea treated Ebeta thalassaemia . - pubmed
There was no change in PCV , Hb and spectrin content of RBC membrane after HU therapy for 90 days in Ebeta thalassaemia . - pubmed
T - plastin is expressed in epithelial and mesenchymal cells of solid tissues , whereas L - plastin is expressed in mobile cells such as hemopoietic cell lineages and cancer cells . - pubmed
Expression and clinical significance of osteopontin in calcified breast tissue . - pubmed
In our study , we used semi - quantitative RT - PCR of osteopontin in calcification tissue of breast to detect breast cancer metastasis . - pubmed
The obtained data indicate that the expression of osteopontin is related to calcification tissue of breast , and possibly with the incidence of breast cancer . - pubmed
The expression strength of OPN by RT - PCR detection was related to the degree of malignancy of breast lesions , suggesting a close relationship between OPN and breast calcification tissue . - pubmed
The results revealed that expression of OPN mRNA is related to calcification of breast cancer tissue and to the development of breast cancer . - pubmed
Determination of OPN mRNA expression can be expected to be a guide to clinical therapy and prediction of the prognosis of breast cancer patients . - pubmed
The BCAAs are particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism is profoundly altered in insulin resistant conditions and/or insulin deficiency . - pubmed
A repeated - measures ANOVA ( group factor : treatment group and control group ; time factor : initial visit , 1.5 , 3 , and 6 months ) was used to analyze the probing depth ( PD ) , CAL , bleeding on probing ( BOP ) , high - sensitivity C - reactive protein ( hsCRP ) , glycated hemoglobin ( HbA1c ) , and fasting plasma glucose . - pubmed
PURPOSE : To determine the functional discrepancy between the two liver lobes using technetium 99 m ( ( 99m ) Tc ) diethylenetriamine - pentaacetic acid - galactosyl human serum albumin ( GSA diethylenetriamine - pentaacetic acid - galactosyl human serum albumin ) single photon emission computed tomography ( SPECT)/computed tomography ( CT ) fusion imaging following preoperative biliary drainage and portal vein embolization ( PVE portal vein embolization ) in patients with jaundice who have bile duct cancer ( BDC bile duct cancer ) . - pubmed
Preoperative ( 99m ) Tc - GSA diethylenetriamine - pentaacetic acid - galactosyl human serum albumin SPECT / CT fusion images from 32 patients with extrahepatic BDC bile duct cancer were retrospectively reviewed . - pubmed
While stimulation of formyl peptide receptors ( FPRs ) on the surface of human neutrophils induces several immune responses , under conditions of continuous activation of the receptor by agonists such as formyl - Met - Leu - Phe - OH ( fMLP ) , neutrophil - dependent tissue damage ensues . - pubmed
Using material from cohorts of genetically diagnosed Ewing sarcoma with EWSR1 chromosomal translocations , confocal images of tissue microarrays were segmented with level sets and watershed algorithms . - pubmed
A prognostic classifier for Ewing sarcoma with low cross - validation error rates ( 0.36 ) was comprised of multiple features , including the Ki67 proliferative marker and a sub - population of cells with low cytoplasmic / nuclear ratio of CD99 . - pubmed
We performed additional testing in two genomic regions ( P2RX4 / P2RX7 and P2RY1 ) in a cohort from the Prevalence , Prediction , and Prevention of Diabetes in Botnia ( n = 3504 ) , which includes more refined measures of glucose homeostasis . - pubmed
In the Prevalence , Prediction , and Prevention of Diabetes in Botnia study , the minor allele in the missense functional variant rs1718119 ( A348 T ) in P2RX7 was associated with increased insulin sensitivity and secretion , consistent with its known effect on increased pore function . - pubmed
Both male and female P2x7 - C57 mice demonstrated impaired glucose tolerance compared with matched P2x7 - 129 mice . - pubmed
CONCLUSIONS : We show association of the purinergic signaling pathway in general and hypofunctioning P2X7 variants in particular with impaired glucose homeostasis in both mice and humans . - pubmed
Human leukocyte antigen - DRB1 polymorphism in childhood acute lymphoblastic leukemia . - pubmed
Similar to autoimmune diseases , there are clear associations between resistance or susceptibility to cancer and the classic human leukocyte antigen ( HLA ) profile of an individual . - pubmed
The present study aimed to determine the association between the HLA - DRB1 genotype and susceptibility to ALL in children and to assess the prognostic value of HLA - DRB1 alleles in these patients . - pubmed
In conclusion , the HLA - DRB1 * 04 allele appears to be a female - specific susceptibility factor for the acquisition of childhood ALL and it may affect the age of onset of ALL . - pubmed
In addition , the HLA - DRB1 * 11 allele may be of prognostic significance in childhood ALL . - pubmed
Laboratory data revealed a normal cell blood count and beta hcg levels of 8047 IU / L. Because of continuing abdominal pain and a diagnosis of ectopic pregnancy a diagnostic laparoscopy was performed , which showed hemoperitoneum . - pubmed
An alternative pathway involves the leukocyte heme protein myeloperoxidase , which catalyzes the oxidation of thiocyanate in the presence of hydrogen peroxide , producing isocyanate at inflammation sites . - pubmed
Recently , it has been shown that carbamylated low - density lipoprotein ( LDL ) induces endothelial dysfunction via lectin - like - oxidized LDL receptor-1 activation and increased reactive oxygen species production , leading to endothelial nitric oxide synthase uncoupling . - pubmed
MATERIALS / METHODS : Six Lewis rats received interphotoreceptor retinoid - binding protein ( IRBP ) emulsion to induce EAU . - pubmed
We compared the preventive effects of fosaprepitant , a neurokinin-1 ( NK1 ) receptor antagonist , with those of ondansetron on PONV in patients who underwent lower limb surgery with postoperative epidural opioid administration . - pubmed
IGF-1 Levels are Inversely Associated With Metabolic Syndrome in Obstructive Sleep Apnea . - pubmed
STUDY OBJECTIVES : This study examined insulin - like growth factor-1 ( IGF-1 ) production and its association with the metabolic syndrome ( MS ) in men with obstructive sleep apnea ( OSA ) . - pubmed
RESULTS : IGF-1 level in the moderate - severe OSA group was lower than in the no - OSA group ( 156.8 + - 54.3 mug / L versus 225.5 + - 80.5 mug / L ; p = 0.013 ) . - pubmed
Furthermore , in the lowest tertile of IGF-1 value , 66.7 % of patients were affected by MS ( p = 0.049 ) . - pubmed
CONCLUSION : The occurrence of OSA is associated with a reduction in IGF-1 levels . - pubmed
The best clinical performance to discriminate CC from cervical intraepithelial neoplasia 2 to 3 was the one for the combination of anti - E4 and/or anti - E7 antibodies , which displayed high sensitivity ( 93.3 % ) and moderate specificity ( 64.1 % ) , followed by anti - E4 and anti - E7 antibodies ( 73.3 % and 80 % ; 89.6 % and 66 % , respectively ) . - pubmed
In addition , the sensitivity of anti - E4 and/or anti - E7 antibodies is high at any time of sexual activity ( TSA ) , which suggests they can be biomarkers for the early detection of CC . - pubmed
In Alzheimer ' s disease , soluble Abeta oligomers are believed to play important roles in the disease pathogenesis , and their levels correlate with cognitive impairment . - pubmed
Independent risk factors for survival were administration of chemotherapy with the intention to induce remission , social class 1 and 2 , hepatomegaly , absence of splenomegaly , lower LDH , lower PB blast count , higher haemoglobin , female sex and WHO performance status 0 - 2 . - pubmed
CONCLUSIONS : We replicated and refined earlier findings of impaired glucose metabolism and nigrostriatal degeneration in CBS , highlighting asymmetric cortical and subcortical hypometabolism , symmetrically reduced metabolism in the thalamus , and only a slightly asymmetric reduction in DAT , while D2 / 3 receptors seem to be mainly preserved . - pubmed
BACKGROUND : Aberrant activation of the Hedgehog ( Hh ) pathway is a key driver in the pathogenesis of basal cell carcinomas ( BCCs ) , including patients with BCC nevus syndrome ( BCCNS ) . - pubmed
The microRNA miR-33a suppresses IL-6 - induced tumor progression by binding Twist in gallbladder cancer . - pubmed
Cytokine is a key molecular link between chronic inflammation and gallbladder cancer ( GBC ) progression . - pubmed
The potential mechanism of cytokine - associated modulation of microRNAs ( miRNAs ) expression in GBC progression is not fully understood . - pubmed
In this study , we investigated the biological effects and prognostic significance of interleukin-6 ( IL-6 ) -induced miRNAs in the development of GBC . - pubmed
We identify that inflammatory cytokine , IL-6 promotes proliferation , migration , invasion and epithelial - mesenchymal transition ( EMT ) of GBC both in vitro and in vivo . - pubmed
Among all the changed miRNAs in miRNA profiling , miR-33a expression was significantly decreased in IL-6 treated GBC cell lines , as well as in GBC tissues compared with case - matched normal tissues and cholecystitis tissues . - pubmed
In turn , miR-33a suppresses IL-6 - induced tumor metastasis by directly binding Twist which was identified as an EMT marker . - pubmed
Phosphatase and tensin homolog deleted on chromosome ten ( PTEN ) is a tumor suppressor and a therapeutic target for the metabolic syndrome . - pubmed
Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells . - pubmed
To prospectively identify mechanisms through which HSP90 - dependent cancer cells evade pharmacologic HSP90 blockade , we generated multiple mutant KRAS - driven cancer cell lines with acquired resistance to the purine - scaffold HSP90 inhibitor PU - H71 . - pubmed
The EGR2 targets LAG-3 and 4 - 1BB describe and regulate dysfunctional antigen - specific CD8 + T cells in the tumor microenvironment . - pubmed
Administration of anti - LAG-3 plus anti-4 - 1BB mAbs was therapeutic against tumors in vivo , which correlated with phenotypic normalization . - pubmed
Our results indicate that coexpression of LAG-3 and 4 - 1BB characterize dysfunctional T cells within tumors , and that targeting these receptors has therapeutic utility . - pubmed
Fascin Is Associated With Aggressive Behavior and Poor Outcome in Uterine Carcinosarcoma . - pubmed
It is associated with poor outcomes in human carcinoma , especially in estrogen receptor ( ER )- negative tumors arising in organs normally expressing ER . - pubmed
We sought to evaluate fascin expression in UCS and its relationship to ER status , clinicopathologic indicators of tumor aggressiveness , and survival outcomes . - pubmed
METHOD : Forty - four surgically staged cases of UCS were immunohistochemically evaluated for fascin and estrogen receptor - alpha expression and correlated with clinicopathologic parameters derived from electronic medical records and pathology reports . - pubmed
Increased expression was associated with extrapelvic disease ( P = 0.028 ) , higher stage ( P = 0.021 ) , larger tumor size ( P = 0.032 ) , shorter progression - free interval ( P = 0.035 ) , and reduced estrogen receptor - alpha expression ( P = 0.04 ) . - pubmed
CONCLUSION : Fascin is aberrantly expressed in both elements of UCS and is associated with aggressive behavior and worse outcome . - pubmed
Signaling via the transient receptor potential ( TRP ) ion channel C6 plays a pivotal role in hereditary and sporadic glomerular kidney disease . - pubmed
Several studies have identified gain - of - function mutations of TRPC6 and report induced expression and enhanced channel activity of TRPC6 in association with glomerular diseases . - pubmed
A 37 - year - old Japanese woman suffered from orthostatic hypotension was diagnosed with multiple myeloma ( IgG kappa type ) , and a serological examination revealed the presence of anti - ganglionic nicotinic acetylcholine receptor ( anti - gAChR ) antibodies . - pubmed
She was treated for multiple myeloma , as a result , the autonomic disturbance improved and her anti - gAChR antibody titer decreased to undetectable levels , despite the fact that she only achieved a partial remission of multiple myeloma . - pubmed
SYSTEMIC BETA - BLOCKERS AND RISK OF PROGRESSION TO NEOVASCULAR AGE - RELATED MACULAR DEGENERATION . - pubmed
Patients with nonexudative AMD who initiated ( index date ) BB , a calcium channel blocker ( CCB ) , an angiotensin - converting enzyme / angiotensin receptor blocker , or a diuretic . - pubmed
Patients on BB versus angiotensin - converting enzyme / angiotensin receptor blocker at all time points and BB versus CCB and diuretics at 365 days did not have a significantly lower association with nAMD ( HR : 0.73 - 0.85 ; P & gt ; 0.06 for all comparisons ) . - pubmed
Transforming growth factor beta superfamily regulation of adipose tissue biology in obesity . - pubmed
This review focuses on the recent development in understanding the role of TGFbeta superfamily in the regulation of white , brite and brown adipocyte differentiation , adipose tissue fibrosis , and adipocyte metabolic and endocrine functions . - pubmed
TGFbeta family and their antagonists are produced locally within adipose tissues and their expression levels are altered in obesity . - pubmed
DR4 mediates the progression , invasion , metastasis and survival of colorectal cancer through the Sp1 / NF1 switch axis on genomic locus . - pubmed
The single nucleotide polymorphism ( SNP ) , -397 G & gt ; T ( rs13278062 ) polymorphism , in the promoter of Death Receptor 4 ( DR4 ) had been reported to be associated with a significantly increased risk for bladder cancer . - pubmed
In this study , we performed a case - control study in 1,078 colorectal cancer patients and 1,175 matched healthy controls to evaluate the association of the potential functional genetic variants in DR4 with risk and survival of colorectal cancer . - pubmed
Immunohistochemistry , western blot , and qPCR corroborated that the rs13278062 GT / TT genotypes increased the expression of DR4 protein in colorectal cancer tissues and cells . - pubmed
In conclusion , these findings indicate that DR4 mediated progression , invasion , metastasis and survival of colorectal cancer via the Sp1 / NF1 switch axis on genomics locus . - pubmed
Elucidation of the FKBP25 - 60S Ribosomal Protein L7a Stress Response Signaling During Ischemic Injury . - pubmed
Coimmunoprecipitation and FRET data indicated that FKBP25 translocated into the nucleus , in which it interacted with 60S ribosomal protein L7a , while overexpression FKBP25 protect endothelial cells against OGD injury . - pubmed
CONCLUSION : Our findings reveal that the nuclear import of FKBP25 and binding with 60S ribosomal protein L7a are protective stress responses to ischemia / nitrosaive stress injury . - pubmed
Infection increases insulin resistance and subsequently increases insulin needs . - pubmed
We are reporting a case of a patient with T1DM and severe infection who has reduced insulin needs after starting micafungin therapy . - pubmed
She had uncontrolled diabetes with a glycosylated hemoglobin of 13.4 % ( 18.8 mM ) on admission . - pubmed
Her insulin requirements progressively increased as a result of worsening infection , continuous tube feeds , and multiple debridement surgeries . - pubmed
Results : This is a report of decreased insulin requirements in a patient with T1DM correlating with micafungin administration . - pubmed
Conclusion : We hypothesize that micafungin may inhibit SGLT-1 function and decrease insulin requirements in patient with T1DM . - pubmed
Phase 1b Study of Trebananib Plus Paclitaxel and Trastuzumab in Patients With HER2 - Positive Locally Recurrent or Metastatic Breast Cancer . - pubmed
Trebananib plus trastuzumab and paclitaxel was evaluated in human epidermal growth factor receptor 2 - positive breast cancer in an open - label phase 1b clinical study . - pubmed
PATIENTS AND METHODS : Women with human epidermal growth factor receptor 2 - positive breast cancer received weekly paclitaxel ( 80 mg / m2 ) , trastuzumab ( 8 mg / m2 then 6 mg / kg every 3 weeks ) , and intravenous trebananib ( 10 mg / kg or 30 mg / kg weekly ) beginning week 2 . - pubmed
RESULTS : Forty women were enrolled ; 2 experienced dose - limiting toxicities ( grade 3 ocular transient ischemic attack [ 10 mg / kg cohort ] and grade 3 elevation in gamma - glutamyl transferase [ 30 mg / kg cohort ] ) . - pubmed
Complete pathological response following neoadjuvant FOLFOX chemotherapy in BRCA2 - mutant locally advanced rectal cancer : a case report . - pubmed
The next - generation sequencing analysis revealed the presence of breast cancer gene 2 ( BRCA2 ) somatic mutation and an increased somatic mutational load without microsatellite instability ( MSI ) . - pubmed
Conclusion : Considering the previous improvements of physical and compositional properties of collagen scaffolds and recent manufacturing developments of structural polymer , it is concluded that hybrid strategy is a promising approach to advance further collagen - based scaffolds in CTE . - pubmed
We discovered that only carbon nanoparticle - Pb2 + adducts , not other pollutants or adducts , induced inflammation in human bronchial cells by suppressing the expression of a novel long noncoding RNA lnc - PCK1 - 2:1 , while lnc - PCK1 - 2:1 routinely plays a regulatory role in inhibiting inflammation . - pubmed
There are increasing data showing that cervical neuroendocrine carcinomas may be associated with the human papillomavirus ( HPV ) , especially HPV18 , and most will stain positive for p16 . - pubmed
Although there are no commonly associated mutations , PIK3CA , KRAS , and TP53 are the most frequently found mutations in neuroendocrine tumors . - pubmed
Mid - regional proadrenomedullin ( MR - proADM ) , shows promising results as outcome predictor in patients with sepsis . - pubmed
Plasma total fibroblast growth factor 23 levels are associated with acute kidney injury and mortality in children with acute respiratory distress syndrome . - pubmed
Pre - clinical data suggest that fibroblast growth factor 23 ( FGF23 ) may contribute to pulmonary pathology , and FGF23 is associated with mortality and morbidity , including acute kidney injury ( AKI ) , in non - ARDS cohorts . - pubmed
Here , we assess whether FGF23 is associated with AKI and/or mortality in a cohort of 161 pediatric ARDS patients . - pubmed
Plasma total ( intact + C - terminal ) FGF23 and intact FGF23 concentrations were measured within 24 hours of ARDS diagnosis ( Day 1 ) , and associations with Day 3 AKI and 60 - day mortality were evaluated . - pubmed
In unadjusted models , higher Day 1 total FGF23 was associated with Day 3 AKI ( odds ratio ( OR ) 2.22 [ 95 % confidence interval ( CI ) 1.62 , 3.03 ] , p<0.001 ) , but Day 1 intact FGF23 was not . - pubmed
In a model adjusted for demographics and disease severity , total FGF23 remained associated with AKI ( OR 1.52 [ 95 % CI 1.02 , 2.26 ] , p = 0.039 ) . - pubmed
In a subgroup analysis of patients with Day 1 plasma IL-6 concentrations available , inflammation partially mediated the association between total FGF23 and AKI . - pubmed
Our data suggest both inflammation - dependent and inflammation - independent associations between total FGF23 and clinical outcomes in pediatric ARDS patients . - pubmed
SMA / CORM-2 exerted both in vitro and in vivo anti - proliferation and anti - metastatic effects , which may yield a novel therapeutic strategy for CRC . - pubmed
EXPERIMENTAL DESIGN : Two syngeneic models of oral cavity carcinoma with defined T cell antigens were treated with PD-1 mAb before or after surgical resection of primary tumors , and antigen - specific T cell responses were explored with functional and in vivochallenge assays . - pubmed
Using tumors lacking the immunodominant antigen as a model of antigen escape , neoadjuvant PD-1 immune checkpoint blockade induced effector T cell immunity against tumor cells lacking immunodominant but retaining subdominant antigen . - pubmed
When combined with complete surgical excision , neoadjuvant PD-1 immune checkpoint blockade led to formation of immunologic memory capable of preventing engraftment of tumors lacking the immunodominant but retaining subdominant antigen . - pubmed
CONCLUSIONS : Together , these results implicate PD-1 expression by T cells in the mechanism of functional immunodominance among independent T cell clones within a progressing tumor , and support the use of neoadjuvant PD-1 immune checkpoint blockade in patients with surgically resectable carcinomas . - pubmed
Tau deposition in young adults with drug - resistant focal epilepsy . - pubmed
All formalin - fixed , paraffin - embedded blocks from the surgical specimens from each subject were sectioned and stained with hematoxylin and eosin and antibodies to tau ( Thermo Fisher Scientific Clone AT8 ) , and examined blindly for tau pathology , including lesions characteristic of CTE . - pubmed
Although none of the patients had pathological findings characteristic of CTE , 23 patients ( 38 % ) demonstrated tau - immunoreactive lesions , including neurites , neurofibrillary pretangles , neurofibrillary tangles , subpial tau , and/or glial tau . - pubmed
SIGNIFICANCE : Tau - immunoreactive lesions were found in 38 % of 60 patients who underwent a focal cortical resection for drug - resistant focal epilepsy . - pubmed
Knockdown of NSD2 Suppresses Renal Cell Carcinoma Metastasis by Inhibiting Epithelial - Mesenchymal Transition . - pubmed
Nuclear receptor suppressor of variegation , enhancer of zeste , and trithorax ( SET ) domain - containing 2 ( NSD2 ) , belonging to NSD protein family , functions as an oncogene in the pathogenesis of multiple cancers . - pubmed
Methods : GEO database was used to analyze the expression of NSD2 mRNA in renal cancer . - pubmed
Furthermore , NSD2 protein level in clear cell RCC ( ccRCC ) tissues was detected by immunohistochemistry ( IHC ) . - pubmed
The biological role and molecular mechanism of NSD2 in RCC metastasis were investigated via a series of functional experiments . - pubmed
Results : NSD2 mRNA was massively amplified in several types of renal cancer , especially in metastatic ccRCC . - pubmed
The expression level of NSD2 protein was elevated in ccRCC tissues , but not correlated with pathological grading . - pubmed
The migratory and invasive properties were significantly repressed in NSD2 - silenced RCC cells , concurrent with an increase of E - cadherin expression and a decrease of N - cadherin and Vimentin expression . - pubmed
Conclusion : Down - regulation of NSD2 could potently suppress cell migration and invasion through inhibiting epithelial - mesenchymal transition ( EMT ) , indicating that NSD2 may be a potential therapeutic target for metastatic RCC . - pubmed
miR-21 may Act as a Potential Mediator Between Inflammation and Abnormal Bone Formation in Ankylosing Spondylitis Based on TNF - alpha Concentration - Dependent Manner Through the JAK2 / STAT3 Pathway . - pubmed
Objective : To explore the role of microRNA ( miR-21 ) in new bone formation in ankylosing spondylitis ( AS ) as mediated by different concentration of tumor necrosis factor - alpha ( TNF - alpha ) . - pubmed
Relative expressions of p - STAT3 , Nuclear STAT3 , cytoplasm STAT3 , Runx2 , BMP2 , osteopontin , osteocalcin , and LC3B in AS fibroblasts were measured after exposure to different concentrations of TNF - alpha . - pubmed
We report two rare cases of late - onset brain edema after craniotomy for clipping or coating of unruptured intracranial aneurysms , possibly due to an allergic reaction to topically applied fibrin glue or gelatin sponge used for arachnoid plasty to cover the opened sylvian cistern . - pubmed
Five to six weeks after surgery without complications , MR images showed an extensive T2 prolongated region in the white matter around the operative field , indicative of vasogenic edema , with mass effect and meningeal enhancement around the sylvian fissure that had been covered with gelatin sponge and sprayed fibrin glue . - pubmed
Delayed brain edema may occur around the arachnoid plasty area despite an uneventful chronic postoperative period , which could be due to an allergic reaction to locally administered fibrin glue or gelatin sponge . - pubmed
Thus , the application of arachnoid plasty using fibrin glue and gelatin sponge in patients with a predisposition to allergies needs to be carefully considered . - pubmed
A Novel Role of Growth Differentiation Factor ( GDF )- 15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD . - pubmed
Physical activity ( PA ) , cognitive function ( Japanese version of the Montreal Cognitive Assessment : MOCA - J ) , and the serum GDF-15 levels were assessed in healthy subjects ( n = 14 ) , asthmatics ( n = 22 ) , and COPD patients ( n = 28 ) . - pubmed
Compared to healthy subjects and asthmatics , COPD patients showed the highest serum GDF-15 levels and had a significantly higher proportion of subjects with MCR ( both sedentary lifestyle ( EX < 1.5 ) and cognitive risk ( MoCA - J < = 25 ) ) . - pubmed
Also , we found that serum GDF-15 has a screening potential ( 100 % sensitivity ) greater than aging ( 67 % sensitivity ) for detecting MCR in COPD patients . - pubmed
Sortase - Mediated Site - Specific Modification of Interleukin-2 for the Generation of a Tumor - Targeting Acetazolamide - Cytokine Conjugate . - pubmed
Here , we describe the preparation and in vivo characterization of the first small molecule - cytokine conjugate targeting carbonic anhydrase IX ( CAIX ) , a marker of renal cell carcinoma and hypoxia . - pubmed
The in vivo targeting of structures expressing carbonic anhydrase IX was assessed by biodistribution experiments in tumor - bearing mice . - pubmed
Optimization of manufacturability and tumor - targeting performance of acetazolamide - cytokine products will be required in order to enable industrial applications . - pubmed
OGA Inhibition Alters Energetics and Nutrient Sensing in Alzheimer ' s Disease Cytoplasmic Hybrids . - pubmed
METHODS : We induced increased O - GlcNAc by treating AD and control cybrid cell lines with Thiamet G ( TMG ) , an inhibitor of the O - GlcNAcase enzyme that mediates removal of the nutrient - dependent O - GlcNAc modification . - pubmed
At baseline , AD cybrid cell line mitochondria showed partial activation of several proteins that help maintain bioenergetic homeostasis such as AMP - Regulated Kinase suggesting that AD mitochondria initiate a state of nutrient stress promoting energetic compensation ; however , this compensation reduces the capacity of cells to respond to additional nutrient - related stresses such as TMG treatment . - pubmed
In conditions in which anti - PD-1 , alone or in combination with anti - CTLA-4 , failed to reduce tumor growth in mice receiving a standard diet , KD or oral supplementation of 3HB reestablished therapeutic responses . - pubmed
We also found that tomatidine significantly regulated serum total cholesterol , fasting blood glucose , low - density lipoprotein , and triglyceride levels , but the serum high - density lipoprotein and adiponectin concentrations were higher than in the HFD - fed obese mice . - pubmed
These findings suggest that tomatidine potentially ameliorates obesity and acts against hepatic steatosis by regulating lipogenesis and the sirt1 / AMPK pathway . - pubmed
[ Significance of stimulated serum insulin analysis in diabetes , organic hyperinsulinism ( islet cell adenoma ) and in the so - called " non - hypoglycemic syndrome " ] . - pubmed
Inhibition of liver HMG - CoTA reductase does not appear to account for the hypocholesterolemic effect , and activation of mitochondrial alpha - glycerophosphate dehydrogenase does not explain the hypotriglyceridemic action . - pubmed
Reduction of very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) levels in rats with sucrose - induced hyperlipidemia and normalization of the altered apolipoprotein profiles are in accord with the effects of halofenate on plasma triglyceride and cholesterol levels . - pubmed
The reduced insulin - to - glucagon ratio observed in Zucker obese hyperlipemic rats is also consistent with halofenat 's hypotriglyceridemic activity . - pubmed
Polycythaemia and erythropoietin producing uterine fibromyoma . - pubmed
Deletion of the Hunter gene and both DXS466 and DXS304 in a patient with mucopolysaccharidosis type II . - pubmed
Hunter syndrome is an X - linked mucopolysaccharidosis due to deficiency of the lysosomal enzyme iduronate-2 - sulfatase ( IDS ) . - pubmed
A cDNA clone containing the entire coding region of the human IDS gene , mapped in Xq28 , has been used as molecular probe to study a patient with Hunter syndrome . - pubmed
A submicroscopic deletion has been detected that spans the IDS gene as well as DXS466 and DXS304 , 2 loci mapped probably not more than 900 kb from the IDS locus . - pubmed
Although diabetes appears to be an independent cardiovascular risk factor , increases in total and LDL - cholesterol together with a decrease of HDL - cholesterol are more pronounced in diabetics with cardiovascular disease . - pubmed
When atherogenic indices ( such as the relationship between total cholesterol and HDL - cholesterol or the Apo A1 / apo B quotient ) are used , 20 to 30 % of an IDDM population considered to be in clinically acceptable control have to be considered pathological . - pubmed
Enterotoxin and toxic shock syndrome toxin - one production by staphylococci isolated from mastitis in sheep . - pubmed
The lack of effect of PHV infusion on blood pressure , despite tachycardia and marked cutaneous vasodilatation , implies that PHV has a different effect on the resistance vessels from that of other peptides such as VIP . - pubmed
Receptors , growth factors and steroid insensitivity of tumours . - pubmed
Insulin - mediated glucose metabolism ( euglycemic insulin clamp at plasma insulin concentration of 100 microU / mL ) and glucose - stimulated insulin secretion ( hyperglycemic clamp ) were examined in 42 obese subjects ( ideal body weight [ IBW ] , 158 + /- 4 % ) with normal glucose tolerance and in 36 normal weight ( IBW , 102 % + /- 1 % ) age - matched controls . - pubmed
In 10 obese and eight control subjects , insulin was infused at six rates to increase plasma insulin concentration by approximately 10 , 20 , 40 , 80 , 2,000 , and 20,000 microU / mL. - pubmed
Throughout the physiologic range of plasma insulin concentrations , both the increase in total body glucose uptake and the suppression of hepatic glucose production ( HGP ) were significantly impaired in the obese group ( P less than .001 to .01 ) . - pubmed
At the two highest plasma insulin concentrations , inhibition of HGP and the stimulation of glucose disposal were similar in both the obese and control groups . - pubmed
Insulin secretion during the hyperglycemic ( + /- 125 mg / dL ) clamp was twofold greater in obese subjects than in controls ( P less than .01 ) and was inversely related to the rate of glucose uptake during the insulin clamp ( r = -.438 , P less than .05 ) , but was still unable to normalize glucose disposal ( P less than .05 ) . - pubmed
In conclusion , our results indicate that insulin resistance is a common accompaniment of obesity and can be overcome at supraphysiological insulin concentrations . - pubmed
Especially diabetic patients might be expected to benefit from this therapy , if given preferably as beta 1 - selective blocker that impairs carbohydrate and lipid metabolism in lesser extent . - pubmed
A group of 117 mucinous cystomas were investigated by histochemical methods ( PB / KOH / PAS ; PAT / KOH / Bh / PAS ) , to demonstrate the presence of O - acetylated sialomucin variants in goblet cells of intestinal type component . - pubmed
Moreover , immunohistochemically , by means of anti - chromogranin A monoclonal antibodies , endocrine cells were found in benign , borderline and malignant mucinous cystomas of mixed type . - pubmed
Decreased NA + , K +- ATPase activity in erythrocyte membrane from rheumatoid arthritis patients . - pubmed
The activity of the plasma membrane Na +/ K +- ATPase and cellular sodium ( Nai ) and potassium ( Ki ) content were analysed in RBCs from 15 rheumatoid arthritis ( RA ) and 30 reference subjects ( 11 healthy controls , 12 osteoarthritis and 7 gouty patients ) . - pubmed
The Na / K - ATPase activity was significantly lower in RA patients than in both healthy controls and patients with osteoarthritis or gout . - pubmed
It is hypothesized that the decrease in the Na +/ K +- ATPase activity in RA may be the result of a defective expression of membrane proteins , which is probably related to the altered cell sensitivity observed . - pubmed
Prognostic significance of serum alpha 1 - acid glycoprotein in patients with glioblastoma multiforme : a preliminary communication . - pubmed
The relationship between the levels of serum acute phase reactant proteins ( alpha 1 - acid glycoprotein , alpha 1 - antitrypsin , haptoglobin ) was investigated in patients with glioblastoma multiforme in relation to their prognosis . - pubmed
It is suggested that serum alpha 1 - acid glycoprotein profiles provide prognostic information in patients with glioblastoma multiforme . - pubmed
Neurokinin - induced salivation in the anesthetized rat : a three receptor hypothesis . - pubmed
blocked both acetylcholine- and neurokinin B- , but not substance P- or neurokinin A - induced salivation . - pubmed
, a putative substance P antagonist , reduced responses to mammalian neurokinins but caused a 2 - fold potentiation of acetylcholine - induced salivation . - pubmed
, a novel putative neurokinin B antagonist , significantly reduced substance P- and neurokinin B- but not acetylcholine- or neurokinin A - induced salivation . - pubmed
Based on the differential effects of the three antagonists on neurokinin- and acetylcholine - induced salivation , we hypothesize the existence of three distinct neurokinin receptors in rat salivary gland , and suggest that neurokinin B receptors reside presynaptically . - pubmed
Microsomes prepared from Ehrlich tumor cells were ineffective as inactivators of MAIQ . - pubmed
Low serum bioactive luteinizing hormone in nonorganic male impotence : possible relationship with altered gonadotropin - releasing hormone pulsatility . - pubmed
We determined the biological activity of serum LH in 23 men , aged 25 - 50 yr , complaining of nonorganic impotence of at least 1 - yr duration and 20 normal men . - pubmed
Stimulating and differentiation factors for human B lymphocytes in systemic lupus erythematosus . - pubmed
T cells from 18 untreated SLE patients produced significantly more B cell growth factor ( BCGF ) than did those from normal subjects . - pubmed
The response to BCGF of SAC - stimulated B lymphocytes from SLE patients was higher than that of B lymphocytes from normal individuals . - pubmed
Similarly preactivated B cells from five of seven SLE patients also proliferated upon the addition of interleukin 1 ( IL-1 ) whereas those of normal subjects did not . - pubmed
Simultaneous addition of IL-1 and BCGF had a synergistic proliferative effect on B cells from two of seven SLE patients but not on any of the controls . - pubmed
Interleukin 2 ( IL-2 ) had no proliferative effect in either SLE or normal B cells . - pubmed
Supernatant fractions from T cells of seven of 10 patients with active SLE and three of 10 with inactive SLE induced more IgG production by CESS cells than did those of normal subjects indicating a higher production of B cell differentiation factor by SLE T cells than by those of controls . - pubmed
Our findings may explain the reported preactivation and predifferentiation of peripheral blood B cells from SLE patients and give insight into the mechanisms leading to the production of autoantibodies in this disease . - pubmed
Phorbol myristate acetate ( PMA ) suppresses polarization and locomotion and alters F - actin content of Walker carcinosarcoma cells . - pubmed
Changes in shape and chemokinesis of Walker carcinosarcoma cells were associated with alterations in the relative amount and the topographical distribution of F - actin as determined by NBD - phallacidin binding . - pubmed
We show here that hyperkalaemia contributes markedly to the post - nephrectomy increase in adrenal angiotensin II receptors , and that circulating angiotensin II levels persist for an unexpectedly long period after nephrectomy , presumably due to tissue generation of the octapeptide . - pubmed
The initial rate of lecithin : cholesterol acyl transferase and serum concentration of lipids were determined in euthyroid , hypothyroid and hyperthyroid subjects . - pubmed
In rectal tumor patients , particularly at stage IV , the level of PHA - induced BRL and the total number of rosette - forming cells ( RFC ) were lower than in healthy donors . - pubmed
[ RBE determinations of tumours by serum aldolase ? - pubmed
The birefringent optical property of collagen has enabled us to assess the collagen architecture for brain arteries , which are prone to spasm and aneurysm formation . - pubmed
Effects of propranolol and atenolol on immobilization stress - induced hypertension and down - regulation of central beta - adrenoceptors in rats . - pubmed
TCR / CD3 ligation of a TCR - transgenic T lymphoma blocks its proliferation in vitro but does not affect its growth in vivo . - pubmed
A backcrossed mouse line was established homozygous for the autosomal recessive mutation scid ( severe combined immunodeficiency ) and carrying T cells which express transgenic ( tg ) T cell receptor ( TCR ) alpha and beta chains that mediate H-2 class I ( Db)-restricted recognition of a male ( H - Y ) determinant ( TCR - tg SCID mouse ) . - pubmed
A thymoma arose ' spontaneously ' in one of the TCR - tg female SCID mice and the thymoma cells were adopted to factor - independent , in vitro growth in long - term tissue culture . - pubmed
Patients with aplastic anemia ( AA ) respond to immunosuppressive therapy , and several lines of laboratory evidence support a role for cell - mediated immunity in the pathogenesis of marrow failure including expansion of cytotoxic T lymphocytes ( CTL ) in the blood of AA patients , overexpression of inhibitors such as IFN - gamma in the marrow of AA patients , and suppression of hematopoietic cells by CTL in vitro . - pubmed
Our study shows that percentages of HLA - DR+ CD8 + lymphocytes and natural killer ( NK ) cells , CD56 + , were elevated in the marrow of AA patients . - pubmed
Monoclonal antibody against CD11b / CD18 inhibits endotoxin - induced uveitis . - pubmed
PURPOSE : To examine the serial expression of cell adhesion molecules in C3H / HeN mice with endotoxin - induced uveitis , and to study the effect of treatment with a monoclonal antibody against Mac-1 on the development of endotoxin - induced uveitis . - pubmed
METHODS : Immunohistochemical staining was used to document the serial expression of Mac-1 , intercellular adhesion molecule-1 ( ICAM-1 ) , and lymphocyte function - associated antigen-1 ( LFA-1 ) in eyes of C3H / HeN mice with endotoxin - induced uveitis . - pubmed
Treatment with anti - MAC-1 antibody significantly inhibited the development of ocular inflammation when compared with treatment with control IgG ( P & lt ; 0.001 ) . - pubmed
CONCLUSION : Intercellular adhesion molecule-1 is expressed in the eye before clinical or histologic signs of inflammation . - pubmed
Furthermore , treatment with antibody against Mac-1 significantly inhibits the development of endotoxin - induced uveitis in mice and suggests that anti - Mac-1 antibody may be useful for treating acute ocular inflammation . - pubmed
Higher levels of urinary met - haemoglobin were found in dogs with naturally occurring Babesia canis infection ( n = 6 ) than in control subjects ( n = 5 ) . - pubmed
This was a significant finding in that met - haemoglobin has been shown to be nephrotoxic in the dog , especially in the presence of aciduria . - pubmed
The present study was conducted to investigate the effect of zinc deficiency on desaturation of linoleic acid in rats that were initially force - fed fat - free diets to stimulate activity of desaturases . - pubmed
Diffuse drainage , particularly involving the glans penis and corpus spongiosum , is greatly predictive of a poor or no response , reflecting the underlying cavernous smooth muscle myopathy and collagen degenerative alterations in these patients with end - organ failure . - pubmed
Immunological mechanisms , including stimulation of brain microglia and elevation of various inflammatory cytokines , have been implicated in the pathogenesis of Alzheimer ' s disease , where accumulation of beta - amyloid peptide ( A beta ) is one of its main pathological features . - pubmed
Identification of the pathway by which extracellular A beta activates the intracellular PKC - dependent secretion of TNF - alpha may help in developing new therapeutic strategies for Alzheimer ' s disease . - pubmed
Topical delivery of tranilast ( N -( 3,4 - dimethoxycinnamoyl ) anthranic acid ) , an inhibitor of collagen synthesis and a therapeutic drug for keloid and hypertrophic scar , was examined , in rats , with oleic acid alone or a combination of oleic acid and propylene glycol as penetration enhancer . - pubmed
Somatic mutations of the beta - catenin gene are frequent in mouse and human hepatocellular carcinomas . - pubmed
The Wnt - beta - catenin pathway is activated in colon cancers and some melanoma cell lines , but has not yet been investigated in HCC . - pubmed
We have examined the status of the beta - catenin gene in different transgenic mouse lines of HCC obtained with the oncogenes c - myc or H - ras . - pubmed
Fifty percent of the hepatic tumors in these transgenic mice had activating somatic mutations within the beta - catenin gene similar to those found in colon cancers and melanomas . - pubmed
Thus alterations in the beta - catenin gene frequently are selected for during liver tumorigenesis and suggest that disregulation of the Wnt - beta - catenin pathway is a major event in the development of HCC in humans and mice . - pubmed
These results show that adenosine potentiates insulin- and contraction - stimulated glucose transport in skeletal muscle by enhancing the increase in GLUT4 at the cell surface and raise the possibility that decreased adenosine production or action could play a causative role in insulin resistance . - pubmed
Genetic dissection of Alzheimer ' s disease and related dementias : amyloid and its relationship to tau . - pubmed
Recent data also suggests that dysfunction in the cytoskeletal protein tau is on the pathway that leads to neurodegeneration and dementia . - pubmed
Tau is produced either indirectly , by A beta 42 , or directly , in some forms of frontotemporal dementia by mutations in tau itself . - pubmed
OBJECTIVE : To assess the variability of synovial histology , immunohistology , and cytokine mRNA expression at different sites within the knee joints of subjects with rheumatoid arthritis receiving slow acting antirheumatic drugs . - pubmed
HIV-2 antigen was detectable in peripheral blood mononuclear cell ( PBMC ) cocultures in all animals after 10 days of HIV-2 infection ; a rapid decline in CD4(+ ) PBMC ( & lt;350 / microliter ) was seen in five of six animals 21 days and 28 days after infection . - pubmed
Monoclonal antibody specific for tissue factor pathway inhibitor - factor Xa complex : its characterization and application to plasmas from patients with disseminated intravascular coagulation and pre - disseminated intravascular coagulation . - pubmed
The normal range assessed from analyses of plasma from 30 normal healthy volunteers was 17.7 - 66.7 with a mean of 35.5 + /- 11.7 pmol / l. In order to asses the clinical implication of TFPI - Xa complex in the plasma of patients with thrombotic disorders , plasma concentrations were measured in 37 patients with disseminated intravascular coagulation ( DIC ) caused by a variety of underlying diseases . - pubmed
The TFPI - Xa antigen levels were significantly higher in the patients with DIC ( 51.9 + /- 21.6 pmol / l ) and the 36 patients with pre - DIC ( 55.1 + /- 20.2 pmol / l ) than in the 137 non - DIC patients ( 37.9 + /- 13.1 pmol / l ) . - pubmed
In the patients with DIC or pre - DIC , there was no significant correlation between TFPI - Xa complex and the elevated levels of thrombin - antithrombin complex , plasmin - alpha2 plasmin inhibitor complex , D - dimer , soluble fibrin monomer , soluble thrombomodulin or tissue factor . - pubmed
Utility of nuclear matrix protein ( NMP22 ) in the detection of recurrent bladder cancer . - pubmed
This article examines the Nuclear Matrix Protein ( NMP22 ) urine test for recurrent bladder cancer detection . - pubmed
Moreover , HDGF colocalizes with the proliferating cell nuclear antigen ( PCNA ) in SMCs in human atherosclerotic carotid arteries , suggesting that HDGF helps regulate SMC growth during development and in response to vascular injury . - pubmed
Cytokine dysregulation in activated cystic fibrosis ( CF ) peripheral lymphocytes . - pubmed
Recent studies demonstrate in vivo and in vitro cytokine dysregulation in CF epithelial cells . - pubmed
To see if these abnormalities may be generalized to other cells expressing cystic fibrosis transmembrane conductance regulator ( CFTR ) but not directly exposed to local inflammation , we studied mRNA transcription , intracellular protein production and extracellular secretion of IL-2 , IL-4 , IL-5 , IL-10 and interferon - gamma ( IFN - gamma ) from freshly isolated blood mononuclear and CD4 + T cells from CF patients and controls . - pubmed
These findings extend defects described in respiratory epithelial cells to circulating immunoregulatory cells , suggesting a link between CF genotype and cytokine dysregulation . - pubmed
Reduced CD44 standard expression is associated with tumour recurrence and unfavourable outcome in differentiated thyroid carcinoma . - pubmed
CD44 was detected with an antibody recognizing all forms of CD44 ( CD44 standard ) and others specific for its v3 and v6 variant isoforms ; their prognostic value was evaluated in 213 patients with differentiated thyroid carcinoma ( DTC ) . - pubmed
The staining patterns of CD44 standard ( s ) and CD44v6 in tumour tissue were quite similar , 176 cases ( 83 % ) being highly positive for CD44s and 153 cases ( 72 % ) for CD44v6 . - pubmed
Only 18 ( 9 % ) tumours showed high expression of CD44v3 . - pubmed
Papillary carcinomas were significantly more often high expressors of CD44s and CD44v6 than follicular carcinomas ( p<0.001 for both ) . - pubmed
Tumour recurrence and cancer - related mortality were related to the reduced level of CD44s ( p=0.049 and p=0.042 ) . - pubmed
In univariate analysis , CD44s was the only significant prognostic factor for disease - free survival ( p=0.0488 ) . - pubmed
In multivariate analysis , CD44s and thyroglobulin level were significant prognostic factors for disease - free survival ( p=0.040 and p<0.001 , respectively ) . - pubmed
The reduced level of CD44s in DTC patients seems to be an independent prognostic factor for unfavourable disease outcome . - pubmed
A promising approach to the gene therapy of PD is intrastriatal expression of dopamine - synthesizing enzymes [ tyrosine hydroxylase ( TH ) and aromatic L - amino acid decarboxylase ( AADC ) ] . - pubmed
Therefore , TH and AADC genes were introduced into the striatum in the lesioned side using separate AAV vectors in parkinsonian rats , and the coexpression of TH and AADC resulted in better behavioral recovery compared with TH alone . - pubmed
Another strategy for gene therapy of PD is the protection of dopaminergic neurons in the substantia nigra using an AAV vector containing a glial cell line - derived neurotrophic factor ( GDNF ) gene . - pubmed
Combination of dopamine - supplement gene therapy and GDNF gene therapy would be a logical approach to the treatment of PD . - pubmed
Patients presented slight hypothyroidism with high titers of antithyroperoxidase antibodies . - pubmed
FINDINGS : Baseline studies indicated that the prevalence of anaemia ( haemoglobin & lt ; 110 g / l ) was high ( 54 % ) among schoolchildren , particularly those with high intensities of hookworm and schistosomiasis . - pubmed
Fifteen months after deworming with albendazole and praziquantel the prevalence of anaemia was reduced by a quarter and that of moderate - to - severe anaemia ( haemoglobin & lt;90 g / l ) was reduced by nearly a half . - pubmed
The cost per anaemia case prevented by deworming schoolchildren was in the range US$ 6 - 8 , depending on the haemoglobin threshold used . - pubmed
The maintenance of oxygen supply to the tissues during anaemia involves complex cardiovascular adaptations , including an increase in cardiac output , reduced peripheral resistance and increased oxygen extraction from haemoglobin ( Hb ) . - pubmed
Many potential reasons for erythropoietin - induced hypertension in uraemic patients have been postulated , including increased blood viscosity as haematocrit rises , a reversal of hypoxic vasodilatation , increased blood volume that is not compensated by haemodialysis , ultrafiltration and impaired nitric oxide synthesis , preventing vascular relaxation in response to increased blood viscosity . - pubmed
As the interaction between anaemia and uraemia is very complex , it is not possible to derive the optimal Hb concentration for individual patients by using simple physiological or pathophysiological models and there is a need for good randomized controlled clinical trials to address this issue . - pubmed
The clinical data with ranolazine focuses on its use in chronic stable angina , where it has been shown to increase exercise tolerance and decrease angina compared with placebo and in combination with beta - blockers and calcium - channel blockers . - pubmed
The occurrence of opportunistic infections depends on CD4 count and rises with CD4 decline . - pubmed
Differential cytokine and antibody responses to adult and larval stages of Onchocerca volvulus consistent with the development of concomitant immunity . - pubmed
The possibility of concomitant immunity and its potential mechanisms in Onchocerca volvulus infection were examined by analyzing cytokine and antibody responses to infective larval ( third - stage larvae [ L3 ] and molting L3 [ mL3 ] ) , adult female worm ( F - OvAg ) , and skin microfilaria ( Smf ) antigens in infected individuals in a region of hyperendemicity in Cameroon as a function of age . - pubmed
Patients were stratified by : ( 1 ) prognostic factors ( age ( 75 - 79 or & gt ; or = 80 ) , Charlson comorbidity score , tumor size , nodal status , stage , ER , PR , creatinine , albumin , hemoglobin , and liver function tests ) , ( 2 ) local treatment ( lumpectomy , axillary lymph node dissection ( AxLND ) , radiation ( XRT ) , modified radical mastectomy ( MRM ) ) and ( 3 ) systemic treatment ( tamoxifen , chemotherapy ) . - pubmed
BACKGROUND : Most obese individuals have elevated concentrations of interleukin-6 ( IL-6 ) and tumor necrosis factor - alpha ( TNF - alpha ) , markers of inflammation closely associated with diabetes , hypertension , and stroke . - pubmed
Mesenteric / SAF ratio of IL-6 , TNF - alpha , corticosterone , and gene profiling showed decrease of inflammation after RYGB . - pubmed
[ THE EVOLUTION OF THE GENETIC PROBLEM IN THALASSEMIA ] . - pubmed
The combination of indole-3 - acetic acid ( IAA ) and horseradish peroxidase ( HRP ) has recently been proposed as a novel cancer therapy . - pubmed
Intermittent hypoxic exposure during light phase induces changes in cAMP response element binding protein activity in the rat CA1 hippocampal region : water maze performance correlates . - pubmed
We postulate that IH elicits time - dependent changes in CREB phosphorylation and nuclear binding that may account for decreased neuronal survival and spatial learning deficits in the adult rat . - pubmed
We suggest that CREB changes play an important role in the neurocognitive morbidity of SDB patients . - pubmed
BACKGROUND : The disease - associated form of prion protein ( PrP(res ) ) has been noted in lymphoreticular tissues in patients with variant Creutzfeldt - Jakob disease ( vCJD ) . - pubmed
Presynaptic cannabinoid CB ( 1 ) receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats . - pubmed
We conclude that in the initial phase of septic shock , the activation of presynaptic CB ( 1 ) receptors by endogenously formed cannabinoids contributes to the inhibition of the neurogenic vasopressor response . - pubmed
Biotin - rich , optically clear nuclei express estrogen receptor - beta : tumors with morules may develop under the influence of estrogen and aberrant beta - catenin expression . - pubmed
Recent studies have indicated that aberrant beta - catenin expression may be a common denominator for the morular formation of tumors from various anatomic sites . - pubmed
We investigated a possible role of estrogen receptor ( ER )- beta in the occurrence of tumors that form morules with biotin - rich optically clear nuclei ( BROCN)(BROCN - family tumors ) and its possible relationship with aberrant nuclear / cytoplasmic ( N / C ) beta - catenin expression . - pubmed
We immunostained 14 BROCN - family tumors , including 6 low - grade adenocarcinomas of the fetal lung type , 3 papillary thyroid carcinomas of cribriform - morular variant ( CMV ) , 2 ovarian endometrioid tumors , 2 colonic adenocarcinomas , and 1 gallbladder adenoma , as well as 4 cases of endometrial tissue with BROCN during gestation , for ERbeta , ERalpha , progesterone receptor ( PgR ) , beta - catenin , and , on a subset of cases , c - Fos and MIB-1 as well . - pubmed
In the BROCN - family tumors , the morular cells and budding glandular cells expressed ERbeta in the cytoplasm and BROCN , which overlapped with the N / C expression pattern of beta - catenin . - pubmed
In CMV and ovarian endometrioid tumors , nuclear expression of ERalpha and PgR were observed in association with N / C beta - catenin expression only in the glandular component . - pubmed
The present study indicates that N / C co - localization of ERbeta and beta - catenin is a feature common to the morules with BROCN that appear in the BROCN - family tumors from various anatomic sites . - pubmed
Whether the estrogen - signaling pathway and the Wnt - signaling pathway have crosstalk , cooperating in the development of the BROCN - family tumors , awaits further study . - pubmed
We estimated the relative risk ( RR ) for each lipid parameter , adjusted for C - reactive protein , homocysteine , body mass index , family history , hypertension , diabetes , postmenopausal hormone use , physical activity , alcohol intake , and blood draw parameters . - pubmed
HDL - C - related ratios were the strongest contributors to predicting CHD ( P<0.0001 ) . - pubmed
CONCLUSIONS : Lower levels of HDL - C may be a key discriminator of higher CHD events among postmenopausal women . - pubmed
HDL - C - related ratios ( such as TC / HDL - C ) provide a powerful predictive tool independently of other known CHD risk factors . - pubmed
Regulation of AKT1 expression by beta - catenin / Tcf / Lef signaling in colorectal cancer cells . - pubmed
Several reports implicated AKT in the molecular pathogenesis of different human malignancies and overexpression of AKT was recently demonstrated to be an early event in colorectal carcinogenesis . - pubmed
To elucidate the regulation of AKT expression in colon cancer cells , we generated reporter constructs containing the luciferase gene under the control of different regions derived from the AKT1 promoter / enhancer . - pubmed
Luciferase was stimulated 20- to 50 - fold in SW480 , SW948 and HCT116 CRC cells . - pubmed
Coexpression of a constitutively active beta - catenin mutant in colon cancer cells further enhanced reporter gene activation from the AKT1 promoter / enhancer , whereas it was downregulated by introduction of either wild - type APC or dnTcf-4 . - pubmed
In addition , immunohistochemical staining of tumor sections derived from CRC patients showed elevated expression levels of AKT1 , correlating with enhanced cytoplasmic / nuclear expression of beta - catenin . - pubmed
Finally , given the evidence that ST is a form of sensory epilepsy , new antiepileptic drugs should be tested for potential efficacy as they are developed ; such drugs may include novel N - methyl - D - aspartate receptor antagonists , as well as cannabinoids . - pubmed
The particular endocrine picture of the graft may be explained by a modified GH - hepatocyte interaction due to cold ischemia during preservation resulting in a higher IGF production . - pubmed
The diabetic patients had ferritin levels of 346 mg / l and non - diabetic patients had 218 mg / l ( p = 0.038 ) . - pubmed
Protection against Pseudomonas aeruginosa pneumonia and sepsis - induced lung injury by overexpression of beta - defensin-2 in rats . - pubmed
The purpose of this study was to evaluate the effect of overexpression of BD-2 on lung injury to crudely investigate whether the function of BD-2 in the lung attributed to both antimicrobial action and modulation of the immune response . - pubmed
Recombinant adenovirus carrying an expression cassette of rat BD-2 or control adenovirus carrying empty vector was administered intratracheally to Sprague - Dawley rats 48 h before performing acute lung injury , which was induced either by Pseudomonas aeruginosa infection or by cecal ligation and double puncture ( 2CLP ) . - pubmed
Overexpression of BD-2 reduced alveolar damage , interstitial edema , and infiltration of neutrophils in both models . - pubmed
Modulating the expression level of BD-2 may serve as an approach to attenuate lung injury . - pubmed
Nerve growth factor in treatment and pathogenesis of Alzheimer ' s disease . - pubmed
One molecule that has received much attention in its potential therapeutic role in AD is nerve growth factor ( NGF ) . - pubmed
This review will demonstrate data from humans and animals which promote NGF as a potential therapeutic target by ( 1 ) outlining the hypothesis behind using NGF for the treatment of AD , ( 2 ) reviewing both the normal and AD altered signaling pathways and effects of NGF in the central nervous system ( CNS ) , and ( 3 ) examining the results of NGF treatment obtained from animal models of AD and AD patients . - pubmed
The independent prognostic value of the biopsy results for forecasting eventual biochemical outcome and overall survival was tested with other factors ( the Gleason score , 1992 American Joint Committee on Cancer tumor stage , pretreatment prostate - specific antigen level , risk group , and RT dose ) in a multivariate analysis . - pubmed
Of the tumors , 4 ( 7 % ; 1 plasmacytoma and 3 MMs ) were EBV - encoded RNA ( EBER)-positive with plasmablastic cytomorphologic features in 3 . - pubmed
Inflammatory processes , such as phagocytosis , coagulation , and vascular dilation , promote the release of serine proteases by neutrophils , macrophages , mast cells , lymphocytes , and the epithelial or endothelial cells . - pubmed
In conditions such as infection , cancer , tissue injury during surgery , kidney disease , vascular disease , coagulation , and diabetes , the concentrations of Bik in plasma and urine are increased . - pubmed
SUP markedly attenuated seizure - induced hippocampal neurodegeneration , dentate cell proliferation , and hippocampal GFAP mRNA expression levels , prevented the loss of hippocampal GAD65 protein and mRNA expression , and altered growth factor expression patterns . - pubmed
SUP also enhanced pre - seizure hippocampal levels of BDNF , NGF , and IGF-1 , which may confer a neuroprotective hippocampal microenvironment that dampens the neuropathological response to and/or helps facilitate recovery from SE to protect cognitive function . - pubmed
Expression profile and prognostic importance in prostate lesions of the reverse transcriptase component of human telomerase ( hTERT ) and of cyclin - dependent kinase inhibitor p57 ( p57kip2a ) . - pubmed
OBJECTIVES : To investigate expression of the reverse transcriptase component of human telomerase ( hTERT ) and of cyclin - dependent kinase inhibitor p57 ( p57 ( kip2a ) ) in prostate neoplasms and evaluate the relationship between these proteins and the Gleason score . - pubmed
METHODS : hTERT and p57(kip2a ) antibodies were studied by immunohistochemical methods in 70 prostate adenocarcinomas ( 33 high - grade and 37 low - grade carcinomas ) , 29 benign prostate hyperplasias , and 19 prostatic intraepithelial neoplasias ( PIN ) . - pubmed
RESULTS : Immunohistochemical histologic scores ( HSCOREs ) of hTERT were significantly higher in the PIN group than in the hyperplasia group ( P = 0.03 ) . - pubmed
hTERT HSCOREs were not significantly different between hyperplasias and carcinomas or between low and high - grade carcinomas . - pubmed
p57 ( kip2a ) HSCOREs were significantly higher in hyperplasias than other groups , and in PINS than carcinomas , but did not differ significantly between low and high - grade carcinomas . - pubmed
A significant negative correlation was observed between hTERT and p57 ( kip2a ) ( P = 0.007 ) in the hyperplasia group . - pubmed
Loss of p57 ( kip2a ) control on hTERT might have an important role in the development of prostate cancer . - pubmed
In 2006 the protein TDP-43 was identified as the major ubiquitinated component deposited in the inclusion bodies found in two human neurodegenerative diseases , amyotrophic lateral sclerosis and frontotemporal lobar degeneration . - pubmed
Now , in 2008 , several papers have been published in quick succession describing mutations in the TDP-43 gene , showing they can be a primary cause of amyotrophic lateral sclerosis . - pubmed
There are many precedents in neurodegenerative disease in which rare single - gene mutations have given great insight into understanding disease processes , which is why the TDP-43 mutations are potentially very important . - pubmed
A VEGF trap inhibits the beneficial effect of bFGF on vasoreactivity in corporal tissues of hypercholesterolemic rabbits . - pubmed
Previous studies have shown that intracorporal injection ( ICI ) of basic fibroblast growth factor ( bFGF ) reverses some of the detrimental vasoreactivity effects of hypercholesterolemia and increases vascular endothelial growth factor ( VEGF ) expression . - pubmed
Five new consanguineous families with horizontal gaze palsy and progressive scoliosis and novel ROBO3 mutations . - pubmed
Horizontal gaze palsy and progressive scoliosis ( HGPPS ) is an autosomal recessive neurologic disorder caused by homozygous or compound heterozygous mutations in the ROBO3 gene on chromosome 11 . - pubmed
The ROBO3 gene does not appear to have an obvious hot spot area for mutations ; therefore , we recommend sequencing all exons and exon - intron boundaries in patients with clinical and/or radiologic features of HGPPS . - pubmed
Before treatment , the median level of WBC was 4.3 x 10(9)/L and the detection rate of abnormal promyelocyte on blood film was 85.8 % ; with immunophenotypic detection , the expression levels of CD117 , CD34 , HLA - DR , CD7 , CD14 and CD19 in APL were found to be lower and the expression levels of CD2 , CD33 and MPO higher than those in other subtypes of acute myelocytic leukemia ( AML ) ( both P & lt ; 0.01 ) . - pubmed
The 4th patient was a case of LCH with primary pulmonary involvement diagnosed on the basis of HRCT and lavage with an immunohistochemical proof ( expression of CD1 and of protein S-100 ) of a high number of Langerhans cells . - pubmed
Transcriptional interaction of an estrogen receptor splice variant and ErbB4 suggests convergence in gene susceptibility pathways in schizophrenia . - pubmed
Previously , we found that DNA sequence variation in the estrogen receptor ( ER ) alpha gene , lower ERalpha mRNA levels , and/or blunted ERalpha signaling is associated with schizophrenia . - pubmed
In addition , we determined the extent to which ERalpha interacts with NRG1 - ErbB4 , a leading schizophrenia susceptibility pathway . - pubmed
Reductions in the transcriptionally active form of ErbB4 comprising the intracytoplasmic domain ( ErbB4 - ICD ) have been found in schizophrenia , and we hypothesized that ERalpha and ErbB4 may converge to control gene expression . - pubmed
Our findings demonstrate convergence between ERalpha and ErbB4 - ICD in the transcriptional control of ERalpha - target gene expression and suggest that this may represent a convergent pathway that may be disrupted in schizophrenia . - pubmed
AIMS : Clinically , Chlamydia pneumoniae infection and its heat shock protein 60 ( cHSP60 ) may contribute to atherogenesis ; however , its underlying mechanisms are largely unknown . - pubmed
The objective of this study was to determine whether cHSP60 could cause endothelial dysfunction in human coronary artery endothelial cells ( HCAECs ) and porcine coronary arteries . - pubmed
CONCLUSION : cHSP60 directly induces eNOS downregulation through oxidative stress and MAPK activation in both HCAECs and porcine coronary arteries , thereby causing endothelial dysfunction . - pubmed
[ Detection rate of MAGE - A1 - A6 mRNA in the peripheral blood of cancer patients ] . - pubmed
The mRNA expression of 6 MAGE - A ( MAGE - A1 - A6 ) antigens by the tumor focal cells and cancer cells circulating in blood was studied in solid malignant and benign neoplasms . - pubmed
MAGE - A1 - A6 mRNA expression was detected in the tumor focal cells in more than 90 % of cases of cancer of the breast , lung , and stomach and melanoma cell lines . - pubmed
The detection rate of peripheral blood MAGE - A1 - A6 - positive tumor cells was 95 % in lung cancer , 53 % in corpus uteri cancer , 67 % in gastric cancer , 63 % in breast cancer , 33 % in melanoma , and 42 % in uterine myoma . - pubmed
Efficacy of SSRIs on cognition of Alzheimer ' s disease patients treated with cholinesterase inhibitors . - pubmed
BACKGROUND : This study examines the joint effect on cognition of selective serotonin re - uptake inhibitors ( SSRIs ) and cholinesterase inhibitors ( AChEIs ) in depressed patients affected by Alzheimer ' s disease ( AD ) living at home . - pubmed
In the United Kingdom , the National Institute for Health and Clinical Excellence recommends etanercept , a human recombinant tumour necrosis factor ( TNF ) receptor fusion protein , for moderate to severe psoriasis patients who have failed conventional therapies . - pubmed
Adalimumab , a fully human , anti - TNF monoclonal antibody , is approved for treatment of moderate to severe psoriasis . - pubmed
Gastric acid secretion , pepsinogen , and gastrin were measured preoperatively in 14 patients who have developed Barrett ' s esophagus ( Group I ) , and the results were compared to 24 patients who did not develop Barrett ' s esophagus ( Group II ) . - pubmed
CONCLUSIONS : Barrett ' s esophagus in the esophageal stump was associated to high preoperative levels of gastric acid secretion , serum pepsinogen , and also gastritis in the transposed stomach . - pubmed
Phenotypic spectrum of hereditary neuralgic amyotrophy caused by the SEPT9 R88W mutation . - pubmed
Mutations in the septin 9 ( SEPT9 ) gene were recently identified in some HNA patients . - pubmed
The phenotypic spectrum of HNA caused by SEPT9 mutations is not well known . - pubmed
OBJECTIVE : To characterise the phenotype of a large family of HNA patients with the SEPT9 R88W mutation . - pubmed
Wider and more universal recognition of clinical hallmarks and genetic counselling are of diagnostic importance for HNA caused by the SEPT9 mutation . - pubmed
A20 ( also known as TNFAIP3 ) is a cytoplasmic protein that plays a key role in the negative regulation of inflammation and immunity . - pubmed
Polymorphisms in the A20 gene locus have been identified as risk alleles for multiple human autoimmune diseases , and A20 has also been proposed to function as a tumor suppressor in several human B - cell lymphomas . - pubmed
Next , we will delineate the signalling pathways importantly governed by transforming growth factor beta ( TGFbeta ) in the control of cardiac fibrosis . - pubmed
We investigated the knockdown of individual CerS in the MCF-7 human breast adenocarcinoma cell line by using small - interfering RNA ( siRNA ) . - pubmed
SGK3 is an estrogen - inducible kinase promoting estrogen - mediated survival of breast cancer cells . - pubmed
Recent study revealed that SGK3 plays a pivotal role in Akt / protein kinase B independent signaling downstream of oncogenic PI3KCA mutations in breast cancer . - pubmed
Here we report that SGK3 is an estrogen receptor ( ER ) transcriptional target and promotes estrogen - mediated cell survival of ER - positive breast cancer cells . - pubmed
Through a meta - analysis on 22 microarray studies of breast cancer in the Oncomine database , we found that the expression of SGK3 is significantly higher ( 5.7 - fold , P & lt ; 0.001 ) in ER - positive tumors than in ER - negative tumors . - pubmed
In ER - positive breast cancer cells , SGK3 expression was found to be induced by 17beta - estradiol ( E(2 ) ) in a dose- and time - dependent manner , and the induction of SGK3 mRNA by E(2 ) is independent of newly synthesized proteins . - pubmed
Loss - of - function analysis indicated that SGK3 is required for E(2)-mediated cell survival of MCF-7 breast carcinoma cells . - pubmed
Together , our study defines the molecular mechanism of regulation of SGK3 by estrogen / ER and provides a new link between the PI3 K pathway and ER signaling as well as a new estrogen - mediated cell survival mechanism mediated by SGK3 in breast cancer cells . - pubmed
Aromatase inhibitors ( AIs ) were more effective than tamoxifen as a neoadjuvant endocrine therapy ( NAE ) for postmenopausal women with estrogen receptor ( ER )- positive breast cancer . - pubmed
Predictive markers of neoadjuvant AIs may be ER - rich , progesterone receptor ( PgR)-rich and human epidermal growth factor receptor 2 ( HER2 )- negative tumors . - pubmed
Pathological tumor size , nodal status , Ki67 level , and ER score are predictive for the survival of postmenopausal women with breast cancer who have been treated with NAE . - pubmed
RESULTS : Here we analyze the 3D telomere dynamics by Q - FISH in the novel Hodgkin cell line U - HO1 and its non - receptor protein - tyrosine phosphatase N1 ( PTPN1 ) stable transfectant U - HO1 - PTPN1 , derived from a primary refractory Hodgkin ' s lymphoma . - pubmed
Novel role of mitochondrial matrix metalloproteinase-2 in the development of diabetic retinopathy . - pubmed
Matrix metalloproteinase-2 ( MMP2 ) becomes activated and proapoptotic , and the therapies that inhibit the development of diabetic retinopathy alleviate MMP2 activation . - pubmed
The authors sought to elucidate the possible mechanism by which activated MMP2 contributes to mitochondrial dysfunction . - pubmed
METHODS : The effect of the regulation of MMP2 on mitochondrial dysfunction and the subcellular localization of the molecular chaperone important for mitochondrial integrity ( Hsp60 ) and gap junction protein connexin 43 were investigated in retinal endothelial cells . - pubmed
The results were confirmed in retinal mitochondria isolated from diabetic mouse overexpressing MnSOD and in the retinas of normal rats that received intravitreal administration of MMP2 . - pubmed
In mice , the overexpression of MnSOD protected retinal mitochondria from diabetes - induced increases in MMP2 and decreases in Hsp60 and connexin 43 . - pubmed
Better understanding of MMP2 - mediated mitochondrial damage could help identify new strategies for the treatment of this blinding disease . - pubmed
Blood pressure - dependent and independent effects of amlodipine and angiotensin receptor blockers on the risk of stroke . - pubmed
In the male patients ( n=169 , mean age : 61 years ) who had no apparent carotid arterial stenosis and cerebrovascular disease , a history of CAD , current smoking , body mass index , blood pressure , hemoglobin A1c , serum low - density - lipoprotein cholesterol , estimated glomerular filtration rate and ultrasonic measures of CCA diameter were analyzed . - pubmed
We aimed to compare the effects of aspirin and prodrugs of aspirin ( 1 - 5 ) on human platelet aggregation stimulated by ADP and collagen and associated receptor expression ( GPIIb / IIIa and P - selectin ) in platelet - rich plasma ( PRP ) and washed platelets ( WP ) . - pubmed
The mechanism of prodrug - induced platelet aggregation inhibition was explored by studying the effects of plasma and purified human BuChE on aggregation . - pubmed
KEY FINDINGS : ST0702 , 2 , a nicotinic acid - aspirin codrug was equipotent with aspirin with respect to inhibition of collagen - induced platelet aggregation . - pubmed
While previous studies have addressed the role of tumor necrosis factor ( TNF )- alpha and matrix metalloproteinases ( MMPs ) in HSK , the mechanistic link between TNF - alpha and MMPs in the pathogenesis of HSK remains elusive . - pubmed
CONCLUSIONS : Our findings shed new light on the pathogenesis of HSK and open up new possibility of modulating the TNF - alpha - FAK - ERK signaling cascade to pursue therapeutic measures for HSK . - pubmed
Understanding how the tumor suppressor p53 induces cell cycle arrest or apoptosis is critical for developing chemotherapeutic strategies . - pubmed
Synergistic enhancement of cancer therapy using a combination of heat shock protein targeted HPMA copolymer - drug conjugates and gold nanorod induced hyperthermia . - pubmed
In this study , tumor hyperthermia was utilized as a means to increase the active delivery of heat shock protein ( HSP ) targeted N -( 2 - hydroxypropyl ) methacrylamide ( HPMA ) copolymer - drug conjugates . - pubmed
Following hyperthermia , induced expression of cell surface heat shock protein ( HSP ) glucose regulated protein 78 kDa ( GRP78 ) was utilized for targeted drug therapy . - pubmed
Co - treatment with CCKsv also partially antagonizes Ewing tumor cell growth stimulated by CCK-8 . - pubmed
Sry expression was deregulated in two out of the four tested male rodent hepatocellular carcinoma ( rHCC ) cell lines . - pubmed
Knockdown of Sry robustly lowered anchorage - independent growth , invasiveness and tumorigenicity of rHCC cells , whereas ectopic expression of Sry conferred more malignant properties . - pubmed
Low CD4 count ( & lt ; 50 / mul ) had statistically significant association with HIV / TB co - infection as compared to HIV infection only ( P & lt ; 0.0001 ) . - pubmed
Proteasome inhibition reduced platelet aggregation by low thrombin concentrations and ristocetin - stimulated agglutination through the glycoprotein Ib - IX - V complex . - pubmed
BACKGROUND : Elite controllers maintain high CD4(+ ) T - cell counts and suppress plasma human immunodeficiency virus ( HIV ) viremia in the absence of antiretroviral therapy ( ART ) . - pubmed
RESULTS : CD4(+ ) T - cell counts were similar between elite controllers and HIV - negative controls but significantly lower in ART recipients with suppressed viremia . - pubmed
Patients with metastatic pancreatic cancer presenting with increased values of C - reactive protein do not respond to gemcitabine . - pubmed
Furthermore , human Paca44 pancreatic ductal adenocarcinoma cells were seeded and cultured in 0.5 % FBS containing growth medium plus / minus 1 muM gemcitabine plus / minus recombinant human interleukin ( IL )- 6 . - pubmed
In vitro , the induction of STAT3 phosphorylation by recombinant human IL-6 promoted pancreatic ductal adenocarcinoma cell survival during gemcitabine treatment . - pubmed
In particular , the inflammation biomarkers C - reactive protein , IL-6 , and IL-1alpha could indicate the prognostic benefit of gemcitabine chemotherapy and should now be tested in prospective patient - controlled trials . - pubmed
The mitochondrial transmembrane potential of the tumor cells was detected by laser scanning confocal microscopy , and the activity of caspase-3 , - 8 , - 9 and - 12 was determined . - pubmed
The results of the present study indicate that psPEF may induce apoptosis in a cervical cancer xenograft through the endoplasmic reticulum stress and caspase - dependent signaling pathways . - pubmed
Induction of H2AX phosphorylation in tumor cells by gossypol acetic acid is mediated by phosphatidylinositol 3 - kinase ( PI3 K ) family . - pubmed
Thus , we further examined the possible mechanisms of GAA to induce gammaH2AX in tumor cells . - pubmed
DNA dependent protein kinase ( DNA - PK ) - proficient and -deficient cells , human glioma cell lines M059 K and M059J , were also used to evaluate the kinases responsible for GAA induced H2AX phosphorylation . - pubmed
Lentivirus - mediated RNAi knockdown of the gap junction protein , Cx43 , attenuates the development of vascular restenosis following balloon injury . - pubmed
In the present study , we investigated the role of the gap junction ( GJ ) protein , connexin 43 ( Cx43 ) , in the development of vascular restenosis . - pubmed
In addition , the mRNA and protein expression of Cx43 was temporarily decreased at 7 days , and subsequently increased at 14 and 28 days following balloon injury , as shown by RT - PCR and western blot analysis . - pubmed
To determine the involvement of Cx43 in vascular restenosis , the lentivirus vector expressing shRNA targeting Cx43 , Cx43 - RNAi - LV , was used to silence Cx43 in the rat carotid arteries . - pubmed
The knockdown of Cx43 effectively attenuated the development of intimal hyperplasia and vascular restenosis following balloon injury . - pubmed
Thus , our data indicate the vital role of the GJ protein , Cx43 , in the development of vascular restenosis , and provide new insight into the pathogenesis of vascular restenosis . - pubmed
Cx43 may prove to be a novel potential pharmacological target for the prevention of vascular restenosis following PCI . - pubmed
A higher percentage of patients with hemolysis had anticardiolipin IgM ( p - value=0.002 ) . - pubmed
Associations of low platelet count and hemolysis were found with antiphospholipid syndrome and anticardiolipin IgM positivity , respectively . - pubmed
R4 Regulator of G Protein Signaling ( RGS ) Proteins in Inflammation and Immunity . - pubmed
Additional G protein independent functions of RGS13 have been uncovered in gene expression in B lymphocytes and mast cell - mediated allergic reactions . - pubmed
We also discuss approaches to target RGS proteins therapeutically , which represents a virtually untapped strategy to combat exaggerated immune responses leading to inflammation . - pubmed
Lack of anti - tumor activity by anti - VEGF treatments in hepatic hemangiomas . - pubmed
Recently , anti - vascular endothelial growth factor ( anti - VEGF ) agents have been described in the literature as a valid treatment option for symptomatic liver hemangiomas , but only limited evidence supports this notion . - pubmed
The purpose of this study was to elucidate whether or not the administration of anti - VEGF agents can reliably achieve a size reduction in liver hemangiomas . - pubmed
Our data do not support the application of anti - VEGF agents for the treatment of hepatic hemangiomas . - pubmed
The receiver operating characteristic ( ROC ) analysis were also performed for evaluating nesfatin-1 and orexin - A in distinguishing children with malnutrition from healthy controls . - pubmed
ROC analysis demonstrated that nesfatin-1 and orexin - A can not be used to distinguish children with malnutrition from healthy controls ( AUC : 0.620 , p=0.061 for nesfatin-1 and AUC : 0.584 , p=0.190 for orexin - A ) . - pubmed
Phenotypic observations in " hypotrichosis with juvenile macular dystrophy " ( recessive CDH3 mutations ) . - pubmed
PURPOSE : Recessive mutations in CDH3 cause " hypotrichosis with juvenile macular dystrophy , " typically recognized by the presence of prominent dermatological features . - pubmed
CONCLUSIONS : Ophthalmologists should consider the diagnosis of CDH3 - related retinopathy in individuals with such clinical features whether or not there is frank hypotrichosis . - pubmed
These observations prompted the US FDA to revise statin labels to include a warning of an increased risk of incident diabetes mellitus as a result of increases in glycosylated hemoglobin ( HbA1c ) and fasting plasma glucose . - pubmed
LY294002 induces differentiation and inhibits invasion of glioblastoma cells by targeting GSK-3beta and MMP . - pubmed
Here we show that the traditional phosphatidylinositol 3 kinase ( PI3 K ) inhibitor LY294002 is capable of inducing differentiation of C6 glioblastoma cells characterized by morphological changes to astrocytic phenotype , increase in differentiation marker protein glial fibrillary acidic protein and inhibition of proliferation . - pubmed
Taken together , these findings suggest differentiation - inducing and invasion - inhibitory effectiveness of LY294002 in glioblastomas , most likely involving inhibition of GSK-3beta and MMP respectively . - pubmed
Low - Density Lipoprotein Cholesterol , Non - High - Density Lipoprotein Cholesterol , Triglycerides , and Apolipoprotein B and Cardiovascular Risk in Patients With Manifest Arterial Disease . - pubmed
Low - density lipoprotein cholesterol ( LDL - C ) only partly represents the atherogenic lipid burden , and a growing body of evidence suggests that non - high - density lipoprotein cholesterol ( non - HDL - C ) , triglycerides , and apolipoprotein B ( apoB ) are more accurate in estimating lipid - related cardiovascular disease risk . - pubmed
Our objective was to compare the relation among LDL - C , non - HDL - C , triglycerides , and apoB and the occurrence of future vascular events and mortality in patients with manifest arterial disease . - pubmed
The relation among LDL - C , non - HDL - C , and cardiovascular events was comparable in patients with cerebrovascular disease , coronary artery disease , or polyvascular disease and absent in those with aneurysm of abdominal aorta or peripheral artery disease . - pubmed
In conclusion , in patients with a history of cerebrovascular , coronary artery , or polyvascular disease , but not aneurysm of abdominal aorta or peripheral artery disease , higher levels of LDL - C and non - HDL - C are related to increased risk of future MACE and of comparable magnitude . - pubmed
BACKGROUND : TRPV4 , a non - selective cation channel , is involved in lipometabolism and atherosclerosis . - pubmed
This study may serve as an important first step for further investigation into the roles of TRPV4 in macrophage - derived foam cell formation in atherosclerosis . - pubmed
ATM mutation and radiosensitivity : An opportunity in the therapy of mantle cell lymphoma . - pubmed
ATM is the most frequently mutated gene in MCL and recent experimental evidence demonstrated that this mutational status can be taken advantage of using radiotherapy . - pubmed
Mechanosensory Stimulation Evokes Acute Concussion - Like Behavior by Activating GIRKs Coupled to Muscarinic Receptors in a Simple Vertebrate . - pubmed
Head skin stimulation activates a cholinergic pathway which then opens G protein - coupled inward - rectifying potassium channels ( GIRKs ) via postsynaptic M2 muscarinic receptors to inhibit brainstem neurons critical for the initiation and maintenance of swimming for up to minutes and can explain many features commonly observed immediately after concussion . - pubmed
We propose that some acute symptoms of concussion in vertebrates can be explained by the opening of GIRKs following mechanosensory stimulation to the head . - pubmed
Neuropsychiatric Manifestations of Pediatric NMDA Receptor Autoimmune Encephalitis : A Case Series From a Tertiary Care Center in India . - pubmed
Objective : Although psychiatric manifestations are one of the most common presentations of pediatric N - methyl - D - aspartate receptor ( NMDAR ) encephalitis , there is a lack of studies that characterize psychiatric aspects of this disorder . - pubmed
POU2F1 promotes growth and metastasis of hepatocellular carcinoma through the FAT1 signaling pathway . - pubmed
Increasing evidence suggests that POU domain class 2 transcription factor 1 ( POU2F1 ) participates in carcinogenesis and cancer progression via promotion of cell proliferation and metastasis ; however , the functional role of POU2F1 in hepatocellular carcinoma ( HCC ) is largely unknown . - pubmed
In this study , we determined that POU2F1 was significantly up - regulated in HCC tumor tissue and cell lines . - pubmed
We demonstrated that POU2F1 over - expression promoted HCC cell proliferation , colony formation , migration , and invasion , while silencing of POU2F1 inhibited these malignant phenotypes . - pubmed
In vivo experiments indicated that knockdown of POU2F1 inhibited HCC cell metastasis and xenograft growth , whereas ectopic expression of POU2F1 promoted these cellular functions . - pubmed
Functionally , we demonstrated that POU2F1 knockdown induced growth suppression and metastasis inhibition of HCC cells and inactivated the FAT1 pathway , indicating that POU2F1 is a potential novel therapeutic target in HCC . - pubmed
PURPOSE : Though advanced and metastatic epidermal growth factor receptor 2 ( HER2 )- positive disease is not curable , a small proportion of patients with HER2 - positive metastatic breast cancer remain in prolonged complete remission with anti - HER2 treatment . - pubmed
We hypothesized that some cases of HER2 - positive metastatic breast cancer may be curable . - pubmed
METHODS : We retrospectively evaluated the data of patients diagnosed with HER2 - positive metastatic breast cancer who received trastuzumab for more than 2 years as the first - line treatment . - pubmed
Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients . - pubmed
Using a combination of single molecule - based imaging approaches , we here ascertain the presence of circulating autoantibodies against glutamate NMDA receptor ( NMDAR - Ab ) in about 20 % of psychotic patients diagnosed with schizophrenia and very few healthy subjects . - pubmed
We unveil that NMDAR - Ab from psychotic patients alter NMDAR synaptic transmission , supporting a pathogenically relevant role . - pubmed
Thyroperoxidase ( TPO ) activity , was reduced in DM , and MSC treatment did not normalize TPO . - pubmed
TP53 Mutation in Correlation to Immunohistochemical Expression of P53 Protein in Patients with Hepatocellular Carcinoma . - pubmed
BACKGROUND : Mutations causing p53 inactivation are among the most common genetic alterations in human malignant tumours including hepatocellular carcinoma . - pubmed
Detection of p53 gene mutations in patients with hepatocellular carcinoma ( HCC ) should provide relevant data for the patients from the Republic of Macedonia and should allow the survivals additional therapeutic option as is gene therapy . - pubmed
AIM : We aimed to detect p53 gene mutations in HCC tissue , and to correlate them with the immunoexpression of p53 protein and multiple clinicopathologic characteristics of a tumour . - pubmed
Tumour tissue samples were immunostained for p53 and detection of p53 gene mutations was performed by polymerase chain reaction followed by Sanger sequencing . - pubmed
All patients with p53 mutations had cirrhosis . - pubmed
The expression and clinical significance of GADD45A in breast cancer patients . - pubmed
Background : Growth arrest and DNA - damage - inducible protein 45 alpha ( GADD45A ) was previously found to be associated with risk of several kinds of human tumors . - pubmed
Here , we studied the expression and clinical significance of GADD45A in breast cancer . - pubmed
Methods : We performed an immunohistochemical study of GADD45A protein from 419 breast cancer tissues and 116 adjacent non - neoplastic tissues . - pubmed
Results : Significantly high GADD45A expression were observed in breast cancer tissues compared with adjacent non - neoplastic tissues ( P & lt ; 0.001 ) and were independently correlative with estrogen receptor negative ( P = 0.028 ) and high Ki-67 index ( P & lt ; 0.001 ) . - pubmed
Kaplan - Meier survival analysis revealed that patients with high GADD45A expression levels had a worse long - term prognosis in triple negative breast cancer ( P = 0.041 ) , but it was not an independent prognostic factor in multivariate analysis ( P = 0.058 ) . - pubmed
Conclusions : GADD45A expression levels are significantly correlative with estrogen receptor status and Ki-67 index in human breast cancer . - pubmed
Patients with triple negative breast cancer might be stratified into high risk and low risk groups based on the GADD45A expression levels . - pubmed
Synergistic inhibition of aggressive breast cancer cell migration and invasion by cytoplasmic delivery of anti - RhoC silencing RNA and presentation of EPPT1 peptide on " smart " particles . - pubmed
Overexpression of RhoC protein in breast cancer patients has been linked to increased cancer cell invasion , migration , and metastases . - pubmed
Suppressing RhoC expression in aggressive breast cancer cells using silencing RNA ( siRNA ) molecules is a viable strategy to inhibit the metastatic spread of breast cancer . - pubmed
We evaluated the efficacy of EPPT1 peptides presented on the free tips of the PEG brush to function as a targeting ligand against underglycosylated MUC1 ( uMUC1 ) receptors overexpressed on the surface of metastatic breast cancer cells . - pubmed
Results show that " smart " nanoparticles successfully delivered anti - RhoC siRNA into the cytoplasm of aggressive SUM149 and MDA - MB-231 breast cancer cells , which resulted in a dose - dependent inhibition of cell migration and invasion . - pubmed
Moreover , aneuploidy causes up - regulation of the JNK pathway throughout the posterior midgut , and specific inhibition of JNK signaling in ISCs is sufficient to prevent dysplasia . - pubmed
Erdheim - Chester disease ( ECD ) , a rare form of non - Langerhans cell histiocytosis , is characterized by the infiltration of foamy CD68 + and CD1a- histiocytes into multiple organ systems . - pubmed
Central nervous system ( CNS ) involvement has recently been reported to be a poor prognostic factor when treating ECD with interferon alpha . - pubmed
We report the case of a 66 - year - old Japanese patient with ECD involving the CNS who harbored the BRAF V600E mutation and also concomitantly developed polycythemia vera with the JAK2 V617F mutation . - pubmed
Fanconi Anemia and Ataxia Telangiectasia in Siblings who Inherited Unique Combinations of Novel FANCA and ATM Null Mutations . - pubmed
A unique consanguineous family with 2 genomic instability disorders , Fanconi anemia and ataxia telangiectasia , revealed exceptional combinations of null mutations in the FANCA and ATM genes . - pubmed
Two siblings with Fanconi anemia had novel homozygous consecutive microdeletions ( c.1361 - 1370delCCTCCTTTGG , c.1374delC ) adjoined to upstream 65 nucleotide direct tandem repeats and deletion hotspot motifs in the FANCA gene . - pubmed
The sibling with ataxia telangiectasia revealed a homozygous p. Arg2993Stop ( c.8977C>T ) null mutation in the ATM gene . - pubmed
Early Functional Outcomes for Pediatric Patients Diagnosed with Anti - N - Methyl - D - Aspartate Receptor Encephalitis during Inpatient Rehabilitation . - pubmed
OBJECTIVE : The aims of the current study were to characterize the demographic and clinical presentation of pediatric patients diagnosed with anti - N - methyl - D - aspartate receptor encephalitis who require inpatient rehabilitation , to examine early functional outcomes , and to investigate predictors of early recovery . - pubmed
DESIGN : A retrospective chart review was conducted for 27 pediatric patients diagnosed with anti - N - methyl - D - aspartate receptor encephalitis who received intensive inpatient neurorehabilitation . - pubmed
CONCLUSION : Pediatric patients diagnosed with anti - N - methyl - D - aspartate receptor encephalitis displayed significant functional gains during inpatient rehabilitation , despite persistent functional deficits at discharge , suggesting the need for ongoing monitoring and intervention . - pubmed
TO CLAIM CME CREDITS : Complete the self - assessment activity and evaluation online at http://www.physiatry.org/JournalCME CME OBJECTIVES : Upon completion of this article , the reader should be able to ( 1 ) Recognize the clinical presentation of anti - N - methyl - D - aspartate receptor encephalitis in pediatric patients , ( 2 ) Appreciate the role of rehabilitation in the care of the pediatric patient with anti - N - methyl - D - aspartate receptor encephalitis , and ( 3 ) Identify demographic and clinical variables that predict poor functional outcomes after rehabilitation in pediatric patients with anti - N - methyl - D - aspartate receptor encephalitis . - pubmed
In the presence of the EpCAM expressing hepatocellular carcinomas cell line of HepG2 , the specific immune recognition ( Anti - EpCAM / EpCAM ) led to an obvious change of the electron transfer ability . - pubmed
Notably , endothelial vasodilatation of mesenteric arteries was impaired in SHR adolescent offspring exposed to prenatal hypoxia , vascular responses to acetylcholine ( ACh ) and sodium nitroprusside ( SNP ) were reduced , as well as plasma nitric oxide levels and expression of endothelial nitric oxide synthase ( eNOS ) in vessels were decreased . - pubmed
Moreover , mesenteric arteries in SHR offspring following prenatal hypoxia showed enhanced constriction responses to phenylephrine ( PE ) , associated with up - regulated activities of L - type calcium channel ( Ca2 + -dependent ) , RhoA / Rock pathway signaling ( Ca2 + -sensitization ) , and intracellular Ca2 + flow . - pubmed
The Impact of Vitamin D Receptor Gene Polymorphisms on the Susceptibility of Diabetic Vascular Complications : A Meta - Analysis . - pubmed
Background : To determine whether vitamin D receptor ( VDR ) gene polymorphisms are correlated with susceptibility to diabetic vascular complications . - pubmed
Our results showed that there was no correlation between VDR gene TaqI variants and diabetic nephropathy ( DN ) or diabetic retinopathy ( DR ) susceptibility . - pubmed
In comparison with diabetic patients without DN , there was a link between the VDR gene ApaI variant and DN susceptibility under allelic model ( p = 0.029 ) in all populations . - pubmed
The VDR gene FokI variant was also correlated with DN susceptibility under the recessive model ( p = 0.027 ) in the Asian subgroup . - pubmed
In comparison with diabetic patients without DR , we identified a link between the VDR gene ApaI variant and DR susceptibility under the dominant model ( p = 0.034 ) in all populations . - pubmed
Conclusions : The VDR gene BsmI , ApaI , and FokI gene variants are associated with DN and DR susceptibility . - pubmed
No association was found between the VDR gene TaqI gene variants and diabetic vascular complications . - pubmed
The body growth of DEK affected rats was similar to that of normal rats before the development of DM but was attenuated with the deterioration of DM . - pubmed
There was a marked difference in the etiology of DEK by gender : DM phenotypes including polyuria , polydipsia , and hyperglycemia ( nonfasting blood glucose over 300 mg / dl ) were found in male rats aged over 10 weeks but not in female rats . - pubmed
The cumulative incidence of DM in DEK males at the age of 30 weeks was 44.8 % . - pubmed
Oral glucose tolerance tests showed glucose intolerance and decreased insulin secretion in response to glucose loading in affected males , features which were exacerbated with age . - pubmed
Affected males exhibited disorganized architecture of pancreatic islets , decreased numbers of beta cells , and markedly decreased expression of insulin , despite no pathological findings of hemorrhage or infiltration of inflammatory cells in the pancreatic islet . - pubmed
Serum alanine / aspartate aminotransferases ( ALT / AST ) , liver glutathione ( GSH ) depletion , as well as the inflammatory cytokines , such as tumor necrosis factor - alpha ( TNF - alpha ) , interleukin-1beta ( IL-1beta ) , inducible nitric oxide synthase ( iNOS ) , and cyclooxygenase-2 ( COX-2 ) , were analyzed to indicate the underlying protective effects of Rb1 against APAP - induced hepatotoxicity with significant inflammatory responses . - pubmed
In conclusion , experimental data clearly demonstrated that Rb1 exhibited a remarkable liver protective effect against APAP - induced ALI , partly through regulating MAPK and PI3K / Akt signaling pathways - mediated inflammatory responses . - pubmed
Pineoblastoma is uniquely tolerant of mutually exclusive loss of DICER1 , DROSHA or DGCR8 . - pubmed
Potential role of full - length and nonfull - length progranulin in affecting aortic valve calcification . - pubmed
The progranulin ( PGRN ) is an important immunomodulatory factor in a variety of inflammatory diseases , including rheumatoid arthritis , osteoarthritis , inflammatory bowel disease and pneumonia . - pubmed
In primary porcine VICs ( pVICs ) , PGRN downregulated TNF - alpha and alpha - SMA which was accompanied by downregulation of RUNX2 , OPN , OCN , alkaline phosphatase activity and calcium deposition , effects pointing to reduced inflammation , myofibroblastic and osteoblastic transition under calcifying conditions . - pubmed
However , 45 - GRN overexpression promoted OM - induced calcification through activating the Smad1 / 5 / 8 , NF - kappaB and AKT signaling pathways . - pubmed
Collectively , this study provides new insight into the pathogenesis of CAVD , indicating that PGRN is a stratagem in mitigating valve fibrosis / osteoblastic differentiation , and also presenting 45 - GRN as a potential target for the treatment of CAVD . - pubmed
Melatonin inhibits the endoplasmic reticulum stress - induced , C / EBP homologous protein - mediated pathway in acute pancreatitis . - pubmed
The RNA interference method was used to determine the potential role of CHOP in AR42J cells during AP . - pubmed
Increased cerebrospinal fluid YKL-40 levels are associated with disease severity of neuromyelitis optica spectrum disorders . - pubmed
YKL-40 , as a new inflammatory marker , has been studied in many autoimmunity and CNS diseases . - pubmed
Our aim of this study was to investigate cerebrospinal fluid ( CSF ) and serum YKL-40 levels in patients with NMOSD and their association with disease severity . - pubmed
METHODS : We measured CSF and serum YKL-40 levels in 29 patients with NMOSD and 21 age- and sex - matched controls . - pubmed
We analyzed the associations between CSF YKL-40 levels and the clinical variables of NMOSD . - pubmed
RESULTS : Compared to controls , patients with NMOSD had significantly higher CSF YKL-40 levels . - pubmed
CONCLUSIONS : YKL-40 could be a NMOSD severity biomarker and a potential target for NMOSD treatment . - pubmed
Accumulating evidence suggests that severe acute respiratory syndrome coronavirus 2 ( SARS - CoV2 ) is associated with hyper inflammation characterized by excessive release of pro - inflammatory cytokines known as a cytokine storm . - pubmed
In the midst of cytokine storm and coagulopathy , anti - viral agents alone will not provide the much needed therapeutic effect . - pubmed
Hence , the need to combine anti - inflammatory agents such as interferons , angiotensinogen converting enzyme ( ACE ) 2 inhibitors , interleukin - 6 ( IL-6 ) , and Janus kinase ( JAK ) family inhibitors , anticoagulants and other agents involved in inflammation resolution . - pubmed
Keywords : COVID-19 ; SARS - CoV2 ; cytokine storm ; coagulopathy and anti - inflammatory . - pubmed
Our results indicate that trelagliptin reduced plasma lipid levels in NAFLD mice by reducing triglycerides , total cholesterol , low - density lipoprotein cholesterol , and high - density lipoprotein cholesterol . - pubmed
In addition , trelagliptin ameliorated oxidative stress in the liver of NAFLD mice by reducing malondialdehyde and increasing the levels of reduced glutathione and superoxide dismutase activity . - pubmed
This article addresses how guidance for ophthalmologists on managing patients with retinal disease receiving intravitreal injections of anti - vascular endothelial growth factor ( VEGF ) during the pandemic should be adapted to the local epidemic pressure , with more or less stringent measures implemented according to the ebb and flow of the pandemic . - pubmed
METHODS : The Vision Academy 's membership of international retinal disease experts analyzed guidance for anti - VEGF intravitreal injections during the COVID-19 pandemic and graded the recommendations according to three levels of increasing epidemic pressure . - pubmed
METHODS : A multi - centric cross - sectional study in the southeast of France explored the relation between pharmaco - resistance to psychotropic drugs and the prevalence of duplications or polymorphisms of CYP2D6 associated with an ultra - rapid phenotype in children and adolescents with severe mental health disease . - pubmed
We also demonstrate that MRSA infection leads to increased activation of MMP-9 and MMP-2 in RPE cells , while microglia expressed only MMP-9 in MRSA - infected cells . - pubmed
Immunoglobulins in allergic broncho - pulmonary aspergillosis ( ABPA ) . - pubmed
Previously , we have found that the level of glucocorticoid receptor and its mRNA in hepatocellular carcinoma was significantly higher than that of the adjacent liver tissue . - pubmed
This correlated well with the elevated serum alpha - fetoprotein levels in patients with hepatocellular carcinoma . - pubmed
Recently , a female hormone , progesterone , has been found to inhibit the expression of alpha - fetoprotein in hepatoma cells . - pubmed
These results together with our hypothesis that the expression of alpha - fetoprotein is regulated by glucocorticoid receptor complex in proliferating hepatocellular carcinoma cells lead to the conclusion that steroid hormones and/or their antagonists may interfere with the function of glucocorticoid receptors in tumors , consequently regulate tumor growth . - pubmed
We reevaluated the published data on the natural history of FOP and discovered an array of developmental gradients ( characteristic patterns of disease expression ) similar to developmental anomalies induced by pleiotropic mutations of the decapentaplegic ( dpp ) locus in Drosophila melanogaster . - pubmed
The developmental similarities between decapentaplegic in the fly and FOP in man suggest a useful model for the study of FOP . - pubmed
In the treatment of human cancer , the efficacy of the adoptive transfer of lymphokine - activated killer ( LAK ) cells combined with interleukin 2 ( IL2 ) has been emphasized . - pubmed
However , administration of large doses of IL2 may cause significant adverse effects , such as " capillary leak syndrome " . - pubmed
By an immunochemical method ( treatment of sera with staphylococca reagent ) specific rubella IgM were found in 7 ( 100 % ) pregnant women who had experienced clinically manifest rubella , and in 6 ( 14.3 % ) pregnant women with asymptomatic rubella . - pubmed
Myoglobin ( Mb ) levels in pooled urine samples were investigated and compared in patients with different types of hereditary progressive muscular dystrophies ( MD ) . - pubmed
Procoagulant and plasminogen activator activities of bronchoalveolar fluid in patients with pulmonary sarcoidosis . - pubmed
Current evidence suggests that intraalveolar procoagulant ( PC ) and plasminogen activator ( PA ) activities may be important determinants of local fibrin turnover in lung injury . - pubmed
In this study , we measured the PC and PA activities in cell - free bronchoalveolar lavage fluid ( BALF ) obtained from 17 patients with pulmonary sarcoidosis and 12 normal volunteers . - pubmed
Mean PC activity in the sarcoidosis group was significantly elevated ( 102 + /- 25 versus 31.5 + /- 8.1 tissue thromboplastin units / ml ; p less than 0.002 ) , with 6 of 17 patient values beyond the 95 % confidence limits of normals . - pubmed
In contrast , PA activity tended to be lower in the sarcoidosis group ( 0.54 + /- 0.094 versus 0.643 + /- 0.106 Plough units / ml , p less than 0.3 ) , and this difference became significant when PA was normalized to total protein ( p less than 0.001 ) . - pubmed
The ratio of procoagulant activity compared to plasminogen activator ( PC / PA ) was greater in the patients with sarcoidosis than normals ( 258 + /- 54 versus 40.3 + /- 6.4 ; p less than 0.001 ) . - pubmed
In the sarcoidosis group , the PC / PA ratio correlated weakly with the number and percentage of lymphocytes retrieved by BAL . - pubmed
We conclude that in pulmonary sarcoidosis , abnormal expression of procoagulant and plasminogen activator activities in alveolar fluid may favor accumulation of fibrin matrix at inflammatory foci . - pubmed
All coagulation factor activities fell with shock and decreased further with resuscitation in both groups . - pubmed
Inhibition by interferon preparations of a solid malignant tumour and pulmonary metastasis in mice . - pubmed
Production of migration inhibition factor - active lymphokine by liver granulomas and spleens of schistosome - infected nu / nu mice is suggestive of the immune role of B cells in the granulomatous inflammation . - pubmed
Biorich medium alone had an apparent protective effect resulting in amelioration of the cytotoxic effect of Ara - C. Cell cycle analysis of eight subjects showed significant recruitment into S - phase following pre - treatment with cytokines . - pubmed
The A1 - AR agonist binding inhibition evoked by unsaturated FA in many respects is similar to that observed previously following ischaemia and may be contributory to the increased excitability of post - ischaemic brain . - pubmed
One patient with pouchitis pretransplant became negative for antineutrophil cytoplasmic antibody posttransplant but continued to have pouchitis . - pubmed
Alpha - fetoprotein - concanavalin A binding as a marker to discriminate between germ cell tumours and liver diseases . - pubmed
In order to differentiate whether slight alpha - fetoprotein ( AFP ) increases observed in any patient are due to germ cell tumours ( GCT ) or to liver diseases ( including hepatotoxicity of chemotherapy ) , we measured the binding ratio of the AFP to concanavalin A ( ConA ) . - pubmed
Considering a cut - off value to be a ConA binding ratio of 15 % , we distinguished AFP produced by GCT ( & gt ; 15 % ) from AFP produced by tumoral and non - tumoral liver diseases ( & lt ; or = 15 % ) with a sensitivity of 98 % and specificity of 100 % . - pubmed
We did not distinguish AFP produced by tumoral and non - tumoral liver diseases . - pubmed
ConA binding ratio may be a sensitive index to distinguish whether an increase of AFP concentration as low as 15 U / ml in a GCT patient during the follow - up is produced by the tumour or by liver dysfunction ( including hepatotoxicity of chemotherapy ) . - pubmed
The discovery of the plant alkaloid 20 ( S ) camptothecin ( CPT ) , which displayed potent antitumor activity in preclinical trials , has led to the identification of a novel target of cancer chemotherapy : the nuclear enzyme topoisomerase I. - pubmed
The mechanism by which CPT induces cytotoxicity is the topic of continued research , but appears to be mediated by the stabilisation of transient " cleavable " topoisomerase I - DNA complexes . - pubmed
beta - Glucuronidase in common duct bile , methodological aspects , variation of pH optima and relation to gallstones . - pubmed
beta - Glucuronidase of human or bacterial origin may deconjugate bilirubin diglucuronide , causing pigment gallstones . - pubmed
Our results indicate that several pH optima have to be taken into consideration in order to clarify the role of human biliary beta - glucuronidase in the pathogenesis of pigment gallstones . - pubmed
Bacterial beta - glucuronidase activity was associated with duodenal diverticula ( p & lt ; 0.05 ) and common duct stones ( p & lt ; 0.05 ) . - pubmed
Active site - directed antibodies identify calpain II as an early - appearing and pervasive component of neurofibrillary pathology in Alzheimer ' s disease . - pubmed
In Alzheimer ' s disease ( AD ) , the activated form of calpain I is significantly increased while the fate of calpain II has been more difficult to address . - pubmed
Here , calpain II antibodies raised to different sequences within a cryptic region around the active site , which becomes exposed during protease activation , were shown immunohistochemically to bind extensively to neurofibrillary tangles ( NFT ) , neuritic plaques , and neuropil threads in brains from individuals with AD . - pubmed
Total levels of calpain II remained constant in the prefrontal cortex of AD patients but were increased 8 - fold in purified NFT relative to levels of calpain I. - pubmed
These results implicate activated calpain II in neurofibrillary degeneration , provide further evidence for the involvement of the calpain system in AD pathogenesis , and imply that neuronal calcium homeostasis is altered in AD . - pubmed
Mutations in the Ret receptor tyrosine kinase are responsible for a variety of human syndromes , including multiple endocrine neoplasia 2 and Hirschsprung ' s disease . - pubmed
Assessment of inflammation included accumulation of inflammatory cells in the lungs , lung weight , and protein and LDH content of bronchial alveolar lavage fluid ( BALF ) . - pubmed
Radiotherapy continues to have an important role in the treatment of acromegaly and is particularly effective at halting tumour growth , causing tumour shrinkage and reducing growth hormone ( GH ) concentrations in the long term . - pubmed
The 24 hour GH profile in active acromegaly compared with normals , characteristically shows an increased frequency of GH pulses , increased disorderliness ( approximate entropy ) of GH release , increased mean GH valley nadir , increased non - pulsatile fraction of GH and either similar or increased GH pulse amplitude . - pubmed
Complete surgical excision of a GH secreting adenoma may reverse these abnormalities and reduce circulating insulin - like growth factor-1 ( IGF-1 ) concentrations to normal . - pubmed
However , very few data are available regarding the effects of radiotherapy on GH pulsatility in patients with acromegaly . - pubmed
The continuing effects of radiotherapy may potentially transform an individual from a state of GH excess , to a state of GH deficiency , with as yet undetermined effects . - pubmed
This may potentially alter somatostatin ( SMS ) receptor expression on somatotroph adenomas and alter their responsiveness to subsequent SMS analogue therapy . - pubmed
Among the antagonists for putative melatonin receptors studied , neither luzindole ( melatonin MT1 and MT2 receptor antagonist ) nor prazosin ( melatonin MT3 receptor antagonist ) antagonized the melatonin reversal of morphine tolerance and dependence . - pubmed
Further , the melatonin - induced reversal of morphine tolerance and dependence is not mediated through its actions via putative melatonin receptors . - pubmed
CONCLUSIONS : In conclusion , both collagen and ePTFE barriers proved suitable for achieving GBR of osseous defects surrounding dental implants . - pubmed
Effect of intensive lipid - lowering strategy on low - density lipoprotein particle size in patients with type 2 diabetes mellitus . - pubmed
A preponderance of small dense LDL particles is strongly associated with the occurrence of atherosclerotic disease . - pubmed
Although several studies have documented an increased prevalence of small dense LDL particles in diabetes mellitus no data are available to show the effect of lipid - lowering treatment upon the improvement of LDL particle size . - pubmed
In the present study we examined the effect of lipid - lowering treatment , following an intensive lipid - lowering strategy for 30 weeks pursuing ADA recommended target lipid levels , on LDL particle size in 50 type 2 diabetic patients with moderate hyperlipidemia . - pubmed
Although there are numerous mechanisms involved in the process of renal disease progression , the renin - angiotensin system plays a major role as determined by the beneficial response to angiotensin I - converting enzyme inhibitors ( ACEIs ) and angiotensin II receptor blockers ( AT II blockers ) of reduced rate of progression in a variety of clinical and experimental renal diseases . - pubmed
Reversal of this abnormality and reduced stress on capillary walls may be the major mechanisms of beneficial action of ACEIs and AT II blockers in halting renal disease progression . - pubmed
Increasing evidence has indicated that proinflammatory cytokines such as TNF - alpha and IL-1beta , produced by activated microglia and astrocytes , play a key role in progressive degeneration of the nigrostriatal dopaminergic neurons in Parkinson ' s disease ( PD ) . - pubmed
Since alpha - synuclein is a major component of Lewy bodies in PD brains , we studied the constitutive and cytokine / neurotrophic factor - regulated expression of alpha - synuclein in cultured human neurons by Northern blot and Western blot analyses . - pubmed
The levels of alpha - synuclein expression were elevated markedly in NTera2 teratocarcinoma cells following retinoic acid - induced neuronal differentiation , accompanied with an increased expression of synphilin-1 , while they were unaltered in NTera2 - derived differentiated neurons by exposure to TNF - alpha , IL-1beta , BDNF or GDNF . - pubmed
Effect of a matrix metalloproteinase inhibitor on a lymph node metastatic model of gastric cancer cells passaged by orthotopic implantation . - pubmed
In this study , we investigated the effect of R-94138 , a matrix metalloproteinase ( MMP ) inhibitor , on the lymphnodal metastatic ability of gastric cancer cells using an in vivo orthotopic implantation model in nude mice . - pubmed
These findings suggested that the MMP inhibitor , R-94138 , could be used in adjunctive therapy for lymph node metastasis in gastric carcinoma . - pubmed
The glutamate receptor system is implicated in the development and maintenance of epileptic seizures , and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and / or kainate ( KA ) receptor activity . - pubmed
In spite of promising anticonvulsant activity in various animal model studies , no AMPA / KA receptor inhibitors are in clinical use against epilepsy today . - pubmed
Future studies and development of such compounds will indicate whether AMPA / KA receptor inhibition is a feasible therapeutic strategy for the treatment of epilepsy . - pubmed
Association of interleukin-4 and interleukin-1B gene variants with Larsen score progression in rheumatoid arthritis . - pubmed
OBJECTIVE : To perform a genetic association study using markers in the interleukin-1 ( IL-1 ) gene cluster and the IL-4 / IL-4 receptor system genes , seeking evidence for involvement in the onset or the erosive outcome of rheumatoid arthritis ( RA ) . - pubmed
METHODS : We tested the allelic distribution of IL-1A ( +4845 ) , IL-1B ( -511 ) , IL-1B ( +3954 ) , IL-1RN ( +2018 ) , IL-4 variable number of tandem repeat ( VNTR ) , and IL-4R ( +1902 ) in 233 patients with RA , 99 with polymyalgia rheumatica , and 148 ethnically matched controls . - pubmed
Among RA patients , the rarer ( # 2 ) alleles of IL-4 VNTR and IL-1B ( -511 ) were both associated with a milder Larsen score progression : The slope of Larsen progression in the rare allele groups diverged significantly from those of the frequent allele groups after approximately 20 years of disease duration ( P & lt ; 0.001 ) . - pubmed
The rarer alleles of IL-4 VNTR and IL-1B ( -511 ) appear to be associated with a less severe course in RA of long duration . - pubmed
Several lines of reasoning support the use of angiotensin converting enzyme inhibitors or angiotensin receptor blockers as the appropriate first - line therapy in obese patients with uncomplicated hypertension . - pubmed
Clearly , further studies are needed to define target blood pressure levels in obese patients and to clarify the value of established and newer drugs , like angiotensin receptor blockers , for the treatment of obese hypertensive patients . - pubmed
Plasma homocysteine and lipoprotein ( a ) levels as risk factors for atherosclerotic vascular disease in epileptic children taking anticonvulsants . - pubmed
AIM : To assess the effect of anticonvulsant treatment on plasma homocysteine level and lipoprotein ( a ) in epileptic children . - pubmed
METHODS : Plasma total homocysteine , folate , vitamin B12 and lipoprotein ( a ) concentrations were measured in 111 epilectic children taking anticonvulsant drugs for longer than 12 mo . - pubmed
A significant inverse relationship was found between vitamin B12 folate levels and plasma homocysteine levels in the patient group ; 28.8 % of the patient group had lipoprotein ( a ) concentrations above the cut - off value ( 30 mg / dl ) for increased risk of early atherosclerosis , whereas none of the control patients had concentrations above this value . - pubmed
CONCLUSION : These data indicate that prolonged anticonvulsant treatment could increase plasma homocysteine and lipoprotein ( a ) concentrations and that it may be useful to measure the levels routinely in order to prevent atherosclerosis in epileptic children taking anticonvulsant drugs . - pubmed
Cerebrospinal fluid examination during early stage revealed mild leukocytic pleocytosis , elevation of protein and a high level of IL-6 . - pubmed
Mutant med mice are ataxic and lack expression of the Scn8a gene , which encodes the NaV1.6 protein . - pubmed
Comparing the pathogenesis of experimental autoimmune encephalomyelitis in CD4-/- and CD8-/- DBA/1 mice defines qualitative roles of different T cell subsets . - pubmed
Experimental autoimmune encephalomyelitis ( EAE ) was induced with myelin oligodendrocyte glycoprotein ( MOG ( 1 - 125 ) ) in CD4(-/- ) and CD8(-/- ) DBA/1 mice . - pubmed
Both gene - deleted mice developed clinical signs of EAE , albeit milder than in wild - type mice , suggesting that both CD4(+ ) and CD8(+ ) cells participate in disease development . - pubmed
Demyelination and inflammation in the central nervous system was reduced in the absence of CD8(+ ) T cells . - pubmed
Antibody depletion of CD4(+ ) cells completely protected CD8(-/- ) mice from MOG - induced EAE while depletion of CD8(+ ) cells in CD4 (-/- ) mice resulted in fewer EAE incidence compared to that in control antibody - treated mice . - pubmed
Antibody depletion of CD4(+ ) cells in wild - type mice protected from EAE , but not depletion of CD8(+ ) cells , although demyelination was reduced on removal of CD8(+ ) T cells . - pubmed
Immunization with immunodominant MOG(79 - 96 ) peptide led to EAE only in the presence of pertussis toxin ( PT ) in the inoculum . - pubmed
PT also triggered an earlier onset and more severe EAE in CD8(-/- ) mice . - pubmed
We interpret our findings such that in an ontogenic lack of CD4(+ ) T cells , EAE is mediated by CD8(+ ) and elevated levels of alphabetaCD4(-)CD8(- ) cells , and that CNS damage is partly enacted by the activity of CD8(+ ) T cells . - pubmed
The dosage requirements for mammalian TERT in telomere length homeostasis are not known , but are of importance in cellular senescence , stem cell renewal , and cancer . - pubmed
These studies reveal a unique dosage requirement for telomere length maintenance by TERT ; despite haploinsufficiency for the maintenance of long telomeres , mTert+/- mice retain minimal telomere DNA at all chromosome ends and do not exhibit the infertility typical of telomerase - deficient strains . - pubmed
Unexpectedly , mTert+/- mice are ersatz carriers for genetic instability , because their mating led to accelerated genetic instability and infertility in null progeny . - pubmed
Thus , limiting TERT levels play a key role in the maintenance of genome integrity , with important ramifications for the maintenance of short telomeres in human cancer and aging . - pubmed
ECHs are speculated to originate from dermal dendritic subunits and are composed of 2 primary cell populations , ie , CD34 + primitive fibroblastic dendrocytes and factor XIIIa+ histiocytes . - pubmed
ECHs ' putative pathogenesis entails activation of CD34 + " sentinel " reserve dendrocytes , followed by an influx of histiocytes and mast cells . - pubmed
Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody - induced inflammation in Fcgamma receptor IIa - transgenic mice . - pubmed
Our aim was to determine the role of FcgammaRIIa in a transgenic mouse model of immune complex - mediated autoimmunity and to characterize the development of spontaneous autoimmune disease . - pubmed
METHODS : Arthritis was induced in normal and FcgammaRIIa - transgenic mice by immunization with type II collagen ( CII ) or by transfer of arthritogenic anti - CII antibodies . - pubmed
Also , mice that spontaneously developed autoimmune disease were assessed by clinical scoring of affected limbs , histology and serology , and measurement of autoantibody titers and cytokine production . - pubmed
RESULTS : FcgammaRIIa - transgenic mice developed collagen - induced arthritis ( CIA ) more rapidly than did archetypal CIA - sensitive DBA/1 ( H-2q ) mice , while nontransgenic C57BL/6 ( H-2b ) mice did not develop CIA when similarly immunized . - pubmed
Passive transfer of a single dose of anti - CII antibody induced a more rapid , severe arthritis in FcgammaRIIa - transgenic mice than in nontransgenic animals . - pubmed
Elevated IgG2a levels were seen in mice with CIA and in those with spontaneous disease . - pubmed
CONCLUSION : The presence of enhanced passive and induced autoimmunity , as well as the emergence of spontaneous autoimmune disease at 20 - 45 weeks of age , suggest that FcgammaRIIa is a very important factor in the pathogenesis of autoimmune inflammation and a possible target for therapeutic intervention . - pubmed
Regular insulin secretory oscillations despite impaired ATP synthesis in Friedreich Ataxia patients . - pubmed
Friedreich Ataxia is an inherited disorder caused by decreased expression of a mitochondrial protein called frataxin . - pubmed
In the present study Friedreich Ataxia patients with a presumptive impairment of ATP synthesis in pancreatic beta - cells were evaluated for regularity of basal secretory oscillations of insulin . - pubmed
P - gp expression has been reported in chondrosarcoma and hypertrophic chondrocyte in the human growth plate . - pubmed
Histopathological examination revealed a xanthogranulomatous lesion expressing CD68 , but negative for S100 protein , CD1a , CD3 , or CD20 . - pubmed
A morphological study of 200 atherosclerotic carotid sinus ( CS ) plaques obtained at carotid endarterectomy revealed the structural components and processes characteristic for severe atherosclerosis ( foci of atheromatosis and edema , necrosis of collagen and elastic fiber , newly formed vessels and hemorrhages of various duration , lipophages and lymphocytes , portions of fibrosis and calcification , covering thinning and ulceration , thrombi , and the contents of plagues ( atheromatous masses , cholesterol crystals , lipophages , calcificates ) on their surface ) . - pubmed
We discuss a model that large body mass presents an increased cancer risk , which drives the evolution of telomerase suppression and replicative senescence . - pubmed
The function of folliculin ( Flcn ) , encoded by BHD , is totally unknown , although its interaction with Fnip1 has been reported . - pubmed
These results suggest that Flcn - FnipL / Fnip2 and Flcn - Fnip1 complexes positively regulate S6K1 phosphorylation and that FnipL / Fnip2 provides an important clue to elucidating the function of Flcn and the pathogenesis of BHD . - pubmed
Therapeutic effect of low - dose IL-18 combined with IL-10 on collagen - induced arthritis by down - regulation of inflammatory and Th1 responses and induction of Th2 responses . - pubmed
To investigate the anti - inflammatory or pleiotropic immunomodulatory role of interleukin-18 ( IL-18 ) , collagen - induced arthritis ( CIA ) mice were administrated with IL-18 along or in combination with IL-10 , IL-4 or IL-12 . - pubmed
Our results indicated that combined treatment of low - dose IL-18 with IL-10 can prevent the development of CIA , which may be mediated not only by inhibiting Th1 responses through IL-18 / IL-18Ralpha signaling , but also by inducing anti - inflammatory mediators through a GATA-3 - dependent mechanism . - pubmed
In tumor - bearing mice , T cells conditioned with B7 - H3 - blocked on CD40 - activated apoptotic tumor cell - pulsed DCs had a decreased ability to inhibit tumor growth . - pubmed
Therefore , it is hypothesized that high levels of B7 - H3 expression contributes to the ability of CD40 - activated tumor associated DCs in eliciting efficient antitumor immune response , given this fact the potentially significant clinical implications , CD40 - activated DCs merit further considerations when preparing DCs for clinical application . - pubmed
It is known that resistance to chemotherapy in pancreatic cancer is associated with constitutively activated nuclear factor - kappaB ( NF - kappaB ) , which becomes further activated by chemotherapeutic drugs . - pubmed
Our data provide mechanistic evidence for the first time showing that DIM potentiates the killing of pancreatic cancer cells by down - regulation of constitutive as well as drug - induced activation of NF - kappaB and its downstream genes ( Bcl - xL , XIAP , cIAP , and survivin ) . - pubmed
This was accompanied by loss of phospho - p65 and down - regulation of NF - kappaB activity and its downstream genes ( Bcl - xL , survivin , and XIAP ) , which correlated with reduced cell proliferation ( as assessed by Ki-67 immunostaining of tumor specimens ) and evidence of apoptosis [ as assessed by poly ( ADP - ribose ) polymerase cleavage and terminal deoxynucleotidyl transferase - mediated dUTP nick end labeling staining ] . - pubmed
These results provide strong in vivo evidence in support of our hypothesis that DIM could abrogate chemotherapeutic drug ( cisplatin , gemcitabine , and/or oxaliplatin)-induced activation of NF - kappaB , resulting in the chemosensitization of pancreatic tumors to conventional therapeutics . - pubmed
CDKs as therapeutic targets for the human genetic disease tuberous sclerosis ? - pubmed
Taken together , these findings strengthen the argument that besides mTOR - inhibitors , such as rapamycin analogues , p27 and CDKs could also be considered targets for hamartoma therapeutics in tuberous sclerosis . - pubmed
Increased matrix metalloproteinase 9 activity in mild cognitive impairment . - pubmed
Nerve growth factor ( NGF)-dependent cholinergic basal forebrain neurons degenerate during the progression of Alzheimer disease ( AD ) . - pubmed
Elevated proNGF and reduced levels of the TrkA high - affinity NGF receptor occur in prodromal and advanced stages of AD . - pubmed
The analysis demonstrated greater MMP-9 activity in both AD and mild cognitive impairment compared with no cognitive impairment brain samples ( p < 0.01 ) , which supports the notion that a metabolic failure in the NGF - maturation / degradation pathway may be associated with an exacerbated degradation of mNGF in the cerebral cortex in early AD . - pubmed
These findings suggest that a reduction in mNGF as a consequence of MMP-9 - mediated degradation may in part underlie the pathogenesis of cognitive deficits in mild cognitive impairment and AD . - pubmed
Memory B cells and plasma cells specific for the C - terminal region of Merozoite Surface Protein 1 were detectable for more than eight months following primary infection . - pubmed
Polymorphisms in the sialic acid - binding immunoglobulin - like lectin-8 ( Siglec-8 ) gene are associated with susceptibility to asthma . - pubmed
We investigated the genetic association between sequence variants in Siglec-8 and diagnosis of asthma , total levels of serum IgE ( tIgE ) , and diagnosis of eosinophilic esophagitis ( EE ) in diverse populations . - pubmed
However , our association results suggest that the Siglec8 gene may be a susceptibility locus for asthma . - pubmed
Tumor necrosis factor alpha as a marker of systemic and local inflammation in " healthy " smokers . - pubmed
We have not shown any significant relation between pulmonary function and the studied parameters , with only a modest association between forced expiratory volume at one second and forced vital capacity and TNF - alpha levels in EBC . - pubmed
CONCLUSION : Smokers show higher TNF - alpha levels in EBC . - pubmed
We have shown a modest relation between pulmonary function and TNF - alpha levels in EBC . - pubmed
Multivariate analyses pointed to TL as an independent predictor in addition to serum pre - operative PSA for reduced biochemical progression - free survival ( p=0.035 ) . - pubmed
Chronic alcohol - induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock - in mice . - pubmed
There is a need to develop oral models of significant liver injury and to evaluate the possible role of CYP2E1 in ethanol actions in such models . - pubmed
We evaluated chronic ethanol - induced liver injury , steatosis , and oxidant stress in wild - type ( WT ) mice , CYP2E1 knock out ( KO ) mice , and humanized CYP2E1 knock - in ( KI ) mice , in which the human 2E1 was added back to mice deficient in the mouse 2E1 . - pubmed
Significant liver injury was produced in the ethanol - fed KI mice , with elevated transaminases , necrosis , and increased levels of collagen type 1 and smooth muscle actin . - pubmed
This liver injury in the KI mice was associated with elevated oxidant stress and elevated levels of the human CYP2E1 compared to levels of the mouse 2E1 in WT mice . - pubmed
Fatty liver in the WT and the KI mice was associated with lower levels of PPARalpha and acyl - CoA oxidase . - pubmed
These results show that CYP2E1 plays a major role in ethanol - induced fatty liver and oxidant stress . - pubmed
It is the absence of CYP2E1 in the KO mice that is responsible for the blunting of steatosis and oxidant stress because restoring the CYP2E1 restores the fatty liver and oxidant stress . - pubmed
Moreover , it is the human CYP2E1 that restores these effects of ethanol , which suggests that results for fatty liver and oxidant stress from rodent models of ethanol intake and mouse CYP2E1 can be extrapolated to human models of ethanol intake and to human CYP2E1 . - pubmed
Gene silencing of myofibrillogenesis regulator-1 by adenovirus - delivered small interfering RNA suppresses cardiac hypertrophy induced by angiotensin II in mice . - pubmed
Our previous studies proved that myofibrillogenesis regulator ( MR )- 1 has a close relationship with cardiac hypertrophy induced by ANG II . - pubmed
In the present study , we developed a recombinant adenoviral vector ( AdSiR - MR-1 ) driving small interfering ( si)RNA against MR-1 to evaluate its effect on cardiac hypertrophy in vivo . - pubmed
Cardiac hypertrophy was induced by chronic ANG II infusion in mice ; AdSiR - MR-1 was administered via the jugular vein through one bolus injection . - pubmed
ANG II - induced cardiac hypertrophy was suppressed in mice treated with AdSiR - MR-1 , as determined by echocardiography . - pubmed
Morphological and immnohistochemical examinations revealed that interstitial cardiac fibrosis as well as infiltrating inflammatory cells were increased after ANG II infusion ; AdSiR - MR-1 greatly ameliorated these disorders . - pubmed
In ANG II - infused mice , MR-1 silencing also blocked the upregulation of other genes related to cardiac hypertrophy or metabolism of the extracellular matrix . - pubmed
In summary , our results demonstrate the feasibility of MR-1 silencing in vivo and suggest that MR-1 could be a potential new target to treat cardiac hypertrophy induced by ANG II . - pubmed
Then clinical symptoms , and levels of body mass index ( BMI ) , obesity degree , alanine aminotransferase ( ALT ) , aspartate aminotransferase ( AST ) , gamma - glutamyl transpeptidase ( gamma - GT ) , total cholesterol ( TC ) , triglyceride ( TG ) and CT ratio of liver and spleen before and after treatment were compared between two groups . - pubmed
RESULTS : BMI , obesity degree and the levels of ALT , AST , gamma - GT , TC , TG in the serum decreased more significantly in two groups after treatment ( all P<0.05 ) , and there were significant differences between two groups ( all P<0.05 ) , the catgut embedding group decreased more significantly . - pubmed
Exon trapping analysis of c.301 - 19 G & gt ; A in intron 1 of the SHH gene in a patient with a microform of holoprosencephaly . - pubmed
We identified a de novo nucleotide change , c.301 - 19 G & gt ; A , in intron 1 of SHH in a four year old boy with a microform of holoprosencephaly . - pubmed
Chronological study of cytokine transcription in the spleen and lung of chickens after vaccination with serotype 1 Marek ' s disease vaccines . - pubmed
Disruption of blastomeric F - actin : a potential early biomarker of developmental toxicity in zebrafish . - pubmed
In this review , we discuss the potential use of F - actin disruption as a predictive biomarker of developmental toxicity in zebrafish . - pubmed
HGAL protein expression uniformly correlated with GC B - cells in all except a subset of hyaline - vascular CD that showed severe regression of GCs . - pubmed
HGAL staining highlighted dismantled GCs in PTGC , in contrast to weak or absent CD10 and BCL6 staining . - pubmed
Highly sensitive cardiac troponin - I in congenital heart disease . - pubmed
RESULT : Compared with the control group , the cognitive abilities , CAT activities , T - AOC and Ach levels were decreased and NO , MDA and GLu contents were increased in mice after sleep deprivation for 72h . - pubmed
Prognostic impact of insulin receptor expression on survival of patients with nonsmall cell lung cancer . - pubmed
BACKGROUND : The purpose of this study was to characterize insulin receptor ( IR ) and insulin - like growth factor-1 receptor ( IGF-1R ) expression in patients with nonsmall cell lung cancer ( NSCLC ) . - pubmed
Expression of the IR and IGF-1R protein in tumor specimens was assessed immunohistochemically using tissue microarrays . - pubmed
RESULTS : The cytoplasmic IR score was higher in patients with adenocarcinoma ( ADC ) than in those with squamous cell carcinoma ( SCC ) , whereas cytoplasmic IGF-1R score was higher in patients with SCC than those with ADC . - pubmed
Finally , a multivariate analysis revealed the impact of IR , but not of IGF-1R , as an independent predictive marker of NSCLC survival : hazard ratio ( HR ) for OS , 1.005 ( 95 % confidence interval [ CI ] , 1.001 - 1.010 ] , HR for RFS , 1.005 ( 95 % CI , 1.001 - 1.009 ) , when IR score was tested as a continuous variable . - pubmed
CONCLUSIONS : Overexpression of IR predicts a poor survival among patients with NSCLC , especially those with SCC . - pubmed
GIV ( Galpha - interacting vesicle - associated protein ; also known as Girdin ) enhances Akt activation downstream of multiple growth factor- and G protein ( heterotrimeric guanosine 5 '- triphosphate - binding protein )- coupled receptors to trigger cell migration and cancer invasion . - pubmed
Tyrosine phosphorylation of GIV and its association with p85alpha increased during metastatic progression of a breast carcinoma . - pubmed
BACKGROUND : The aim of the study was to investigate variations in anti - infliximab ( IFX ) antibody ( Ab ) levels and clinical implications thereof in patients with inflammatory bowel disease ( IBD ) . - pubmed
METHODS : A retrospective , explorative , single - center study of patients with IBD who developed anti - IFX Ab and in whom anti - IFX Ab were reassessed . - pubmed
Immunoexpression of claudin-1 and Nm23 - H1 in metastatic and nonmetastatic lower lip squamous - cell carcinoma . - pubmed
The aim of this study was to evaluate the immunoexpression of claudin-1 and Nm23 - H1 in metastatic and nonmetastatic lower lip squamous - cell carcinoma ( LLSCC ) . - pubmed
The percentage of claudin-1 staining and the staining intensity and percentage of Nm23 - H1 staining in each tumor core were assessed . - pubmed
Metastatic tumors exhibited higher expression of claudin-1 than nonmetastatic tumors ( P = 0.030 ) . - pubmed
Similarly , stage III and IV LLSCCs showed higher expression of claudin-1 than stages I and II ( P = 0.026 ) . - pubmed
The percentage of claudin-1 staining was scored as 2 in most well - differentiated and moderately differentiated tumors , whereas poorly differentiated tumors showed a relatively similar distribution of scores 2 , 1 , and 0 ( P = 0.648 ) . - pubmed
Regarding Nm23 - H1 , there was a predominance of negative cases for both metastatic and nonmetastatic tumors ( P = 0.235 ) . - pubmed
The results of this study suggest an important role of claudin-1 in the development of metastasis in LLSCCs . - pubmed
In contrast , the present findings do not support a significant role of Nm23 - H1 in metastasis suppression of LLSCC . - pubmed
Multiple endocrine neoplasia 2a ( MEN2a ) syndrome is one of the rare genetic disorder where prophylactic thyroidectomy is recommended for RET mutation carriers due to increased risk for developing MTC during lifetime . - pubmed
Association of NAT2 phenotype with risk of head and neck carcinoma : A meta - analysis . - pubmed
Numerous studies have demonstrated that the polymorphisms of NAT2 were correlated with individual susceptibility to several malignant neoplasms , including head and neck carcinomas ( HNC ) . - pubmed
No significant associations between the rapid acetylator phenotype in NAT2 and HNC risk were found either in the overall analysis ( OR=0.98 ; 95 % CI 0.83 , 1.15 ; I(2)=57 % ; P(heterogeneity)=0.003 ) or in the subgroup analysis by ethnicity ( for the Caucasian population , OR=1.03 , 95 % CI 0.85 , 1.24 , I(2)=63 % , P(heterogeneity)=0.002 ; for other mixed populations , OR=0.78 , 95 % CI=0.61 , 1.00 , I(2)=0 % , P(heterogeneity)=0.47 ) . - pubmed
In conclusion , this meta - analysis suggested that there is no association between the NAT2 phenotype and the risk of HNC . - pubmed
In model systems , progressive glomerular disease is associated with decreased nephrin mRNA steady - state levels compared with podocin mRNA . - pubmed
Src kinase is a direct target of apigenin against UVB - induced skin inflammation . - pubmed
Apigenin inhibited UVB - induced cyclooxygenase-2 ( COX-2 ) expression , which is a well - known key mediator of inflammation and cancer , and restored the upstream stimulatory factor level in JB6 P+ cells . - pubmed
Results using in vivo skin model indicate apigenin significantly inhibits UVB - induced ear edema development , COX-2 expression and Src kinase activity in SKH-1 hairless mice . - pubmed
Collectively , these findings suggest that apigenin exerts potent chemopreventive activity against UVB - induced skin inflammation primarily by targeting Src . - pubmed
Nrf2 is not required for epithelial prohibitin - dependent attenuation of experimental colitis . - pubmed
Expression of the mitochondrial protein prohibitin ( PHB ) is also decreased during intestinal inflammation . - pubmed
Our previous study showed that genetic restoration of colonic epithelial PHB expression [ villin - PHB transgenic ( PHB Tg ) mice ] attenuated dextran sodium sulfate ( DSS)-induced colitis / oxidative stress and sustained expression of colonic nuclear factor erythroid 2 - related factor 2 ( Nrf2 ) , a cytoprotective transcription factor . - pubmed
This study investigated the role of Nrf2 in mediating PHB - induced protection against colitis and expression of the antioxidant response element ( ARE)-regulated antioxidant genes heme oxygenase-1 ( HO-1 ) and NAD ( P ) H quinone oxidoreductase-1 ( NQO-1 ) . - pubmed
PHB Tg , Nrf2(-/- ) , and PHB Tg / Nrf2 (-/- ) mice were treated with DSS or 2,4,6 - trinitrobenzene sulfonic acid ( TNBS ) , and inflammation and expression of HO-1 and NQO-1 were assessed . - pubmed
PHB Tg / Nrf2 (-/- ) mice mimicked PHB Tg mice , with attenuated DSS- or TNBS - induced colitis and induction of colonic HO-1 and NQO-1 expression , despite deletion of Nrf2 . - pubmed
PHB Tg / Nrf2 (-/- ) mice exhibited increased activation of ERK during colitis . - pubmed
Our results suggest that maintaining expression of intestinal epithelial cell PHB , which is decreased during colitis , reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 and NQO-1 via a mechanism independent of Nrf2 . - pubmed
We previously found , in a canine transferable tumor model , that high concentration of IL-6 produced by tumor - infiltrating lymphocytes effectively restores the MHC expression of the tumor cells and T - cell activation inhibited by tumor - derived TGF - beta . - pubmed
Epigenetic regulation of spinal CXCR2 signaling in incisional hypersensitivity in mice . - pubmed
Chemokine CC motif receptor 2 ( CXCR2 ) is a proinflammatory receptor implicated in neuropathic and inflammatory pain and is known to be regulated by histone acetylation in some settings . - pubmed
Blocking CXCR2 reversed mechanical hypersensitivity after hind paw incision . - pubmed
In vitro activation of hTERT - specific T cell responses in lung cancer patients following chemotherapy . - pubmed
OBJECTIVE : The aim of this study was to examine chemotherapy concomitant in vitro activation of human telomerase reverse transcriptase ( hTERT)-specific T cell responses in peripheral blood mononuclear cell ( PBMC ) samples of patients with advanced non - small cell lung cancer ( NSCLC ) . - pubmed
CONCLUSIONS : These results indicate , that concomitant to chemotherapy hTERT - specific T cell responses can be activated in PBMC of NSCLC patients in vitro . - pubmed
Recent evidence supports the hypothesis that tinnitus is related to neuronal hyperactivity in auditory brain regions , and consequently drugs that increase GABAergic neurotransmission in the CNS , such as the GABA ( B ) receptor agonist L - baclofen , may be effective as a treatment . - pubmed
Expression of cellular retinoic acid - binding protein - I ( CRABP - I ) in the cerebrospinal fluid of adult onset moyamoya disease and its association with clinical presentation and postoperative haemodynamic change . - pubmed
OBJECTIVE : The elevation of cellular retinoic acid - binding protein - I ( CRABP - I ) has been suggested as a candidate in the pathogenesis of paediatric moyamoya disease ( MMD ) . - pubmed
However , few studies have addressed CRABP - I in adult onset MMD . - pubmed
The aim of this study was to examine the expression of CRABP - I in the cerebrospinal fluid ( CSF ) of adult onset MMD , and to evaluate its association with clinical presentation and postoperative haemodynamic change . - pubmed
The differences in CRABP - I expression according to disease entity ( unilateral MMD vs bilateral MMD vs ACVD ) , initial presenting symptoms ( haemorrhage vs ischaemia ) and postoperative haemodynamic change ( vascular reserve in single photon emission CT and basal collateral vessels in digital subtraction angiography ) were analysed . - pubmed
RESULTS : CRABP - I intensities in bilateral MMD ( 1.45(0.86 - 2.52 ) ) were significantly higher than in unilateral MMD ( 0.91(0.78 - 1.20 ) ) ( p=0.044 ) or ACVD ( 0.85(0.66 - 1.11 ) ) ( p=0.004 ) . - pubmed
CONCLUSIONS : Higher CRABP - I in the CSF can be associated with typical bilateral MMD pathogenesis in adults . - pubmed
Soluble guanylyl cyclase ( sGC ) degradation and impairment of nitric oxide - mediated responses in urethra from obese mice : reversal by the sGC activator BAY 60 - 2770 . - pubmed
This study investigated the USM relaxant machinery in obese mice and whether soluble guanylyl cyclase ( sGC ) activation with BAY 60 - 2770 [ acid 4 -({( 4 - carboxybutyl ) [ 2 -( 5 - fluoro-2 -{[ 4 -( trifluoromethyl ) biphenyl-4 - yl ] methoxy } phenyl ) ethyl ] amino } methyl ) benzoic ] rescues the urethral reactivity through improvement of sGC - cGMP ( cyclic guanosine monophosphate ) signaling . - pubmed
Reactive - oxygen species ( ROS ) production was enhanced , but protein expression of beta1 second guanylate cyclase subunit was reduced in USM from obese mice , both of which were restored by BAY 60 - 2770 treatment . - pubmed
Long - acting integrase inhibitor protects macaques from intrarectal simian / human immunodeficiency virus . - pubmed
Increased expression of cytokines , soluble cytokine receptors , soluble apoptosis ligand and apoptosis in dengue . - pubmed
In this study , the levels of TNF - alpha , IL-6 , IL-1 , IL-17 , soluble interleukin-1 receptor like 1 protein ( sST2 ) , soluble TNF - related apoptosis - inducing ligand ( sTRAIL ) , IL-12 and soluble receptors for TNF ( sTNF - RI and sTNF - RII ) were determined by ELISA in dengue patients and monocyte / macrophage cultures . - pubmed
CAV-1 contributes to bladder cancer progression by inducing epithelial - to - mesenchymal transition . - pubmed
CAV-1 has been shown to be an oncogene in bladder cancer . - pubmed
However , little is known about the relationship between CAV-1 and EMT in bladder cancer metastasis . - pubmed
CAV-1 and E - cadherin expression levels were measured and correlated with clinical features of tumor grade and metastasis . - pubmed
EMT was assessed in bladder cancer cell lines ( T24 , UMUC3 , HT1376 , and 5637 ) using wound healing and in vitro transwell invasion assays , and small interfering RNA was used to knock down CAV-1 and Slug expression . - pubmed
RESULTS : In this study , we show that increased CAV-1 expression induces bladder cancer cell migration and promotes the EMT , which was determined by the reduction of E - cadherin expression and the induction of N - cadherin and vimentin expression . - pubmed
Slug knockdown abolished the CAV-1 - induced EMT in bladder cancer cells . - pubmed
In addition , positive CAV-1 expression was significantly correlated with negative E - cadherin expression , as determined by immunohistochemistry analysis in bladder cancer tissues . - pubmed
CONCLUSIONS : Our results suggest that CAV-1 promotes invasive phenotypes in bladder cancer cells by inducing EMT through up - regulation of Slug expression , which occurs through activation of the PI3K / AKT signaling pathway . - pubmed
This new role for CAV-1 in promoting bladder cancer metastasis presents CAV-1 and related pathways as potential therapeutic targets in invasive bladder cancer . - pubmed
C3 activation status as expressed by the C3c / native C3 ratio was 2.6 - fold higher ( p<0.01 ) in subjects with NASH despite reduced native C3 concentrations ( 0.94 + -0.12 vs. 0.57 + -0.09 ; p<0.01 ) . - pubmed
C3c , C3 activation status ( C3c / C3 ratio ) and properdin levels increased with higher lobular inflammation scores as determined according to the Kleiner classification ( C3c : p<0.01 , C3c / C3 ratio : p<0.05 , properdin : p<0.05 ) . - pubmed
Hepatic mRNA expression of factor B and factor D did not differ between subjects with healthy livers and subjects with NASH ( factor B : 1.00 + -0.19 vs. 0.71 + -0.07 , p = 0.26 ; factor D : 1.00 + -0.21 vs. 0.66 + -0.14 , p = 0.29 ;) . - pubmed
Hepatic mRNA and protein levels of Decay Accelerating Factor tended to be increased in subjects with NASH ( mRNA : 1.00 + -0.14 vs. 2.37 + -0.72 ; p = 0.22 ; protein : 0.51 + -0.11 vs. 1.97 + -0.67 ; p = 0.28 ) . - pubmed
In contrast , factor H mRNA was downregulated in patients with NASH ( 1.00 + -0.09 vs. 0.71 + -0.06 ; p<0.05 ) and a similar trend was observed with hepatic protein levels ( 1.12 + -0.16 vs. 0.78 + -0.07 ; p = 0.08 ) . - pubmed
RT - qPCR measurement on the expressions of key transcriptional regulators in cardiogenesis showed that BMP4 , NKX2 - 5 , and TBX5 were significantly inhibited at the exposure points of 12 hpf and 24 hpf which may be the internal factors related to the heart developmental toxicity . - pubmed
The principal objective of the current study is to determine the outcomes and clinical management of hyperglycemia in pregnancies complicated by glucokinase gene ( GCK ) and hepatocyte nuclear factor ( HNF )- 1alpha MODY mutations . - pubmed
Seven - point home blood glucose monitoring over a 7 - day period in each trimester demonstrated higher fasting and postprandial glycemic excursions in the first trimester of GCK pregnancies when compared to HNF-1alpha pregnancies ( fasting 104 [ 90 - 115 ] mg / dL vs 84 [ 77 - 88 ] mg / dL ; P = .01 and postprandial 154 [ 135 - 196 ] mg / dL vs 111 [ 100 - 131 ] mg / dL ; P = .04 ) despite insulin treatment . - pubmed
There was a higher percentage of miscarriages in the GCK group when compared to the HNF-1alpha MODY group ( 33.3 % vs 14 % ; P = .07 ) , which was similar to the background population . - pubmed
Insulin initiated at an early gestation appeared to lower the incidence of macrosomia in GCK unaffected offspring . - pubmed
CONCLUSION : Hyperglycemia in HNF-1alpha pregnancies is easily managed with current insulin protocols ; in contrast , glycemic excursions are difficult to manage in GCK pregnancies . - pubmed
Retinol binding protein 4 plasma level in myelodysplastic syndrome subgroups . - pubmed
Loss - of - function mutation in ABCA1 and risk of Alzheimer ' s disease and cerebrovascular disease . - pubmed
METHODS : We tested whether a loss - of - function mutation in ABCA1 , N1800H , is associated with plasma levels of apoE and with risk of Alzheimer ' s disease ( AD ) in 92,726 individuals and with risk of cerebrovascular disease in 64,181 individuals . - pubmed
DISCUSSION : A loss - of - function mutation in ABCA1 , present in 1:500 individuals , was associated with low plasma levels of apoE and with high risk of AD and cerebrovascular disease in the general population . - pubmed
BACKGROUND : Spinocerebellar Ataxia Type 3 / Machado - Joseph Disease ( SCA3 / MJD ) is a hereditary neurodegenerative disorder resulting from the expansion of CAG repeats in the ATXN3 gene . - pubmed
We undertook a national study in order to characterize the ATXN3 gene and to determine the prevalence of SCA3 / MJD in Cuba . - pubmed
OBJECTIVE : The aim of this study was to compare hair thyroid hormone ( TH ) levels among first - episode patients with major depressive disorder ( F - MDD ) , recurrent patients with major depressive disorder ( R - MDD ) and healthy controls ( HC ) . - pubmed
CONCLUSIONS : Our findings suggested that disease duration of recurring episodes of depression may influence hair TH levels . - pubmed
Effectiveness and Feasibility Associated with Switching to a Second or Third TNF Inhibitor in Patients with Psoriatic Arthritis : A Cohort Study from Southern Sweden . - pubmed
OBJECTIVE : Because new modes of action for the treatment of psoriatic arthritis ( PsA ) are emerging , it is important to understand the use of switching to a second or third antitumor necrosis factor ( anti - TNF ) agent . - pubmed
This study investigated drug survival and treatment response rates of patients with PsA undergoing second- and third - line anti - TNF therapy . - pubmed
The mechanisms of reduced ERGF in obese kidney donors are still poorly understood . - pubmed
CAR treatment lowered high serum transaminase activities together with hepatic histopathologic improvements in rats with ASH . - pubmed
Our results indicate that CAR may be effective in suppressing proinflammatory , prooxidant , and profibrotic factors in the liver of rats with ASH . - pubmed
Inhibitory effect of traditional oriental medicine - derived monoamine oxidase B inhibitor on radioresistance of non - small cell lung cancer . - pubmed
In the present study , danshensu which is a selected component of traditional oriental medicine ( TOM ) compound was found to reduce the radioresistance of NSCLC by inhibiting the nuclear factor - kappaB ( NF - kappaB ) pathway . - pubmed
Danshensu decreased the activation of NF - kappaB by inhibiting MAOB activity in A549 and NCI - H1299 NSCLC cells . - pubmed
Taken together , this study shows that danshensu significantly reduces MAOB activity and attenuates NF - kappaB signaling to elicit the radiosensitization of NSCLC . - pubmed
Serum Hepcidin Levels in Childhood - Onset Ischemic Stroke : A Case - Control Study . - pubmed
Despite the growing evidence of iron imbalance in childhood - onset ischemic stroke , serum hepcidin level in those patients has not yet been researched . - pubmed
In this study , we aimed to estimate serum ( hepcidin ) level in acute ischemic stroke ( AIS ) patients and to investigate whether subcutaneous enoxaparin sodium , which is a low - molecular - weight heparin ( LMWH ) derivative , could modulate serum hepcidin level in those patients . - pubmed
The patients were subdivided according to treatment with an LMWH derivative into 2 groups and serum hepcidin levels were assessed initially and 1 week after stroke onset for all cases . - pubmed
We found that AIS cases had higher serum iron , ferritin , and IL6 levels compared to the control group ( all P & lt ; 0.01 ) . - pubmed
Serum hepcidin was significantly higher in AIS cases ( median , 36[15 - 73]ng / mL ) compared to the control group ( median , 24[10 - 41]ng / mL ; P & lt ; 0.01 ) . - pubmed
On the 1st day of AIS diagnosis , serum hepcidin levels were similar in both stroke subgroups ( P & gt ; 0.05 ) . - pubmed
However , on the 7th day of diagnosis serum hepcidin level decreased significantly in AIS cases treated with LMWH ( group 1 ) ( median , 36 vs 21 ng / mL ; P & lt ; 0.01 , respectively ) . - pubmed
Meanwhile , no significant change was observed in serum hepcidin level in AIS cases not treated with LMWH ( group 2 ) ( P & gt ; 0.05 ) . - pubmed
Our data brought a novel observation of elevated serum hepcidin level in pediatric AIS patients and pointed out that treatment with LMWH could modulate hepcidin level in those patients . - pubmed
Bone health assessment by quantitative ultrasound and dual - energy x - ray absorptiometry in postmenopausal women with breast cancer receiving aromatase inhibitors . - pubmed
The aim of the present study was to assess bone status by phalangeal QUS and by dual - energy x - ray absorptiometry ( DXA ) , and to evaluate bone turnover in breast cancer ( BC ) women receiving aromatase inhibitors ( AIs ) . - pubmed
AD - SoS was associated with change of BMD at lumbar spine ( beta , 0.16 ; SE , 0.08 ; P = 0.04 ) and change of BSAP ( beta , -0.04 ; SE , 0.02 ; P = 0.04 ) . - pubmed
Increased epidermal innervation and production of neurotrophins , neuropeptides , cytokines and proteases , in addition to their relations with the sensory receptors in an epidermis with poor lipid mantle , are the aspects currently covered for understanding atopic dermatitis . - pubmed
Exploiting histone deacetylases for cancer therapy : from hematological malignancies to solid tumors . - pubmed
Hypertrophy and osteogenic differentiation events were also activated by production of TGF - beta via rAAV , suggesting that translation of the current approach in vivo will probably require close regulation of expression of this candidate gene . - pubmed
High - mobility group box protein 1 expression in inflammatory diseases of the middle ear . - pubmed
High - mobility group box 1 ( HMGB1 ) is a nuclear non - histone protein , playing a critical role as a mediator between innate and acquired immunity ; when released extracellularly , it coordinates the cellular stress response ( under necrosis , bacterial lipopolysaccharide stimulation ) and acts as an inflammatory marker and cytokine . - pubmed
The aim of the study was to demonstrate whether HMGB1 is over - expressed in chronic middle - ear pathologies and whether the entity of expression and the localization are correlated with the degree of the inflammatory reaction , thus suggesting that HMGB1 may play a crucial role in chronic inflammatory disorders of the middle ear , as already demonstrated in other airway diseases . - pubmed
A statistically significant difference in inflammation score between otosclerosis and chronic otitis samples ( P & lt ; 0.01 ; Anova test ) and between otosclerosis and cholesteatoma samples ( P & lt ; 0.05 ; Anova test ) was observed ; the HMGB1 positivity was in accordance with the density of the inflammatory infiltrate . - pubmed
HMGB1 is over - expressed in chronic middle - ear pathologies and may play a role in the progression of the inflammatory process from recurrent acute otitis media to chronic suppurative otitis media . - pubmed
CCL11 concentration increases dramatically in schizophrenia , Alzheimer ' s disease , neuro - inflammatory disorders , cerebral malaria , drug addiction , as well as in atherosclerosis , periodontal disease , macular degeneration , cancer and other pathologies . - pubmed
In contrast to CCL11 , differentiation growth factor 11 ( GDF11 ) , being administered to old mice , eliminates age - associated hypertrophy of the heart , improves muscle tone and prevents degenerative changes in the CNS , improves cognitive functions and enhances tissue regeneration . - pubmed
At the same time , the higher the GDF11 level in the blood , the milder myocardial infarction , stroke and other age - related diseases of the cardiovascular system . - pubmed
Prevalence and significance of HBeAg and isolated anti - HBc in several institutions for the mentally retarded in the autonomous community of madrid . - pubmed
Hepatitis B virus ( HBV ) surface antigen ( HBsAg ) and antibody to HBsAg ( antiHBs ) are excellent markers for HBV infection and its immunity . - pubmed
Proportionately more Down syndrome chronic carriers of HBsAg acquired the persistent Hepatitis Be antigen ( HBeAg ) than non - Down syndrome patients 15 ( 65.2 % ) vs. 1 ( 20 % ) . - pubmed
The presence of HBeAg was correlated with abnormal liver function and high titres of HBsAg . - pubmed
Testing for the IgM antibody to the hepatitis B core antigen ( IgM AntiHBc ) facilitated the identification of acute and chronic hepatitis infection in both RI and NRC individuals . - pubmed
It is not certain whether the isolated antiHBc seropositivity represents chronic " low levels " of HBV , past infection , or false - positive tests , and whether this test should be employed as a vaccine screening test . - pubmed
Treatment of BCR - ABL+ human leukemia has been significantly improved by ABL tyrosine kinase inhibitors ( TKIs ) , but they are not curative for most patients and relapses are frequently associated with BCR - ABL mutations , warranting new targets for improved treatments . - pubmed
We have now demonstrated that protein expression of human estrogen receptor alpha 36 ( ERalpha36 ) , an alternative splicing variant of human estrogen receptor alpha 66 ( ERalpha66 ) , is highly increased in TKI - insensitive CD34 + chronic myeloid leukemia ( CML ) cells and BCR - ABL - T315I mutant cells , and is abnormally localized in plasma membrane and cytoplasm . - pubmed
Adhesion G protein - coupled receptors ( aGPCRs ) play critical roles in diverse biological processes , including neurodevelopment and cancer progression . - pubmed
Association of CDKAL1 nucleotide variants with the risk of non - syndromic cleft lip with or without cleft palate . - pubmed
This study provides the first evidence that chromosomal region 6p22.3 is a novel susceptibility locus for nsCL / P. The location of the risk variants within the CDKAL1 intronic sequence containing enhancer elements predicted to regulate the SOX4 transcription may suggest that SOX4 , rather than CDKAL1 , is a potential candidate gene for this craniofacial anomaly . - pubmed
These initial local haemodynamic disturbances may trigger fibrin deposition and thrombosis . - pubmed
Both modes of infection require the viral glycoprotein Envelope ( Env ) . - pubmed
Vitamin B12 modulates Parkinson ' s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection . - pubmed
Missense mutations in Leucine - Rich Repeat Kinase 2 ( LRRK2 ) cause the majority of familial and some sporadic forms of Parkinson ' s disease ( PD ) . - pubmed
The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity , promoting the development of LRRK2 kinase inhibitors as therapeutics . - pubmed
Treatment with AdoCbl inhibits LRRK2 kinase activity in cultured cells and brain tissue , and prevents neurotoxicity in cultured primary rodent neurons as well as in transgenic C. - pubmed
Ewing ' s sarcomas are characterized by a CD99 positivity in immunohistochemistry stain and a t(11:22)(q24 : q12 ) translocation in cytogenetic study . - pubmed
The Dephosphorylation of p70S6 ( Thr389 ) Kinase as a Marker of L - Glutamate - Induced Excitotoxicity Related to Diabetes Disturbances - an Unconventional In Vitro Model . - pubmed
It is connected with diabetic disturbance , and it is still being analyzed in the context of the participation of the PI3K / mTOR pathway . - pubmed
A very important protein belonging to this pathway is p70S6 K , whose activation promotes the pathogenesis of type 2 diabetes by the induction of insulin resistance . - pubmed
The three reagents were used in different concentrations to create the model of excitotoxicity related to diabetes disturbances : L - glutamate ( 2.5 mM ; 10 mM ) , glucose ( 150 mM ; 200 mM ) , and insulin ( 0.093 mM ; 0.371 mM ) . - pubmed
The aim of our study was to examine and evaluate the levels of phosphorylation of proteins involved in signal transduction controlled by MAPK , PI3K / Akt , and mTOR signaling pathways in L - glutamate - induced excitotoxicity with comorbid hyperglycemia and hyperinsulinemia imitating diabetic disturbances in in vitro conditions on PC12 cells . - pubmed
This confirms the inhibition of mTOR kinase and suggests that p70S6 K ( Thr389 ) plays a functional role in the regulation of the signaling pathway in excitotoxicity related to diabetic disturbances . - pubmed
Aging ; increased blood glucose , serum uric acid and white blood cells ; decreased serum pH and albumin ; coma ; and preexisting chronic kidney disease ( CKD ) were risk factors of AKI in patients with DKA . - pubmed
Shh Overexpression Is Correlated with GRP78 and AR Expression in Primary Prostate Cancer : Clinicopathological Features and Outcomes in a Chinese Cohort . - pubmed
Introduction : Shh plays an important role in prostate cancer progression , but its correlation with GRP78 and AR is elusive . - pubmed
We performed immunohistochemistry to evaluate the expression of the Shh protein in benign prostatic hyperplasia ( n=96 ) and prostate cancer ( Gleason scores < = 6 [ n=399 ] or > = 7 [ n=44 ] ) . - pubmed
Results : Shh expression was significantly higher in prostate cancer with Gleason scores > = 7 than in cancer with lower Gleason scores or benign hyperplasia and was much higher in AR - positive cancer than in AR - negative cancer . - pubmed
Shh is overexpressed in high - grade prostate cancer and is positively correlated with the expression of both GRP78 and AR . - pubmed
Conclusion : Therefore , Shh may be a useful prognostic marker and therapeutic target for prostate cancer . - pubmed
Results : Compared with the CUMS group , CSS and coadministration of CSS and FLU could alleviate the depressive symptoms and improve cognitive function in CUMS rats ( p < 0.05 ) ; CSS and coadministration of CSS and FLU could increase the expression of BDNF , p - CREB / CREB , p - ERK / ERK , and BDNF mRNA , CREB mRNA , and ERK mRNA in the hippocampus and frontal cortex ( p < 0.05 ) ; CSS and coadministration of CSS and FLU could increase the expression of BDNF , p - CREB / CREB , p - ERK / ERK , and BDNF mRNA , CREB mRNA , and ERK mRNA in the hippocampus and frontal cortex ( p < 0.05 ) ; CSS and coadministration of CSS and FLU could increase the expression of BDNF , p - CREB / CREB , p - ERK / ERK , and BDNF mRNA , CREB mRNA , and ERK mRNA in the hippocampus and frontal cortex ( Discussion and Conclusion . - pubmed
Inflammatory responses mediated by the transcription factor nuclear factor kappa - light - chain enhancer of activated B cells ( NF - kappaB ) play key roles in immunity , autoimmune diseases , and cancer . - pubmed
RESULTS : Ten of 14 ( 71.4 % ) MCs exhibited clinically significant variants , including KRAS , GNAS , and TP53 . - pubmed
Ten of 15 ( 66.7 % ) PDACs had KRAS alterations , and 9 of 15 ( 60 % ) showed variants in TP53 . - pubmed
CONCLUSION : These data indicate that the CeA GABAa receptors play a key role in the regulation of the compulsive cocaine - seeking behavior and suggest that an increase in the function of the GABAa receptors possibly induced by cocaine or genetic factors may be an important mechanism involved in the development of or vulnerability to the compulsive cocaine use and addiction . - pubmed
Choice of Differentiation Media Significantly Impacts Cell Lineage and Response to CFTR Modulators in Fully Differentiated Primary Cultures of Cystic Fibrosis Human Airway Epithelial Cells . - pubmed
Physiological assays ( intracellular / extracellular pH , Ussing chamber ) specifically showed that ATP12A and CFTR function were altered , impacting pH and transepithelial ion transport in CF hAECs . - pubmed
Butyrylcholinesterase ( BChE ) deficiency is characterized by prolonged apnea after the use of muscle relaxants ( suxamethonium or mivacurium ) in patients who have mutations in the BCHE gene . - pubmed
Expression of recombinant BCHE mutants , kinetic analysis and molecular dynamics were undertaken to understand how these mutations induce BChE deficiency . - pubmed
A Progressive Loss of phosphoSer138 - Profilin Aligns with Symptomatic Course in the R6/2 Mouse Model of Huntington ' s Disease : Possible Sex - Dependent Signaling . - pubmed
The R6/2 transgenic mouse model of Huntington ' s disease ( HD ) carries several copies of exon1 of the huntingtin gene that contains a highly pathogenic 120 CAG - repeat expansion . - pubmed
The translational potential of these observations was inferred from preliminary observations of changes in LIMK - cofilin signaling and loss of neurite integrity in neural stem cells derived from an HD patient ( versus a healthy control ) . - pubmed
Our observations suggest that a pre - symptomatic , neurodevelopmental onset of change in the phosphorylation of Ser138 - profilin , potentially downstream of distinct signaling changes in male and female mice , could be contributing to cytoskeletal phenotypes in the R6/2 mouse model of HD pathology . - pubmed
The mechanisms of action for MSC - based cancer treatment include the expression of " suicide genes , " induction of tumor cell apoptosis , and delivery of cytokines to induce an immune response against cancer cells . - pubmed
[ Effect of thyrocalcitonin on the course of postradiation lesions of the jaw bones ] . - pubmed
Effects of zinc sulfate on Pseudomonas aeruginosa infections and protease in rabbit corneas . - pubmed
Taken together these results suggest that although the okadaic acid class of tumor promoters and phorbol ester - related agents bind to two different cellular receptors having counteracting enzymic activities , they share a common mechanism of action , namely the induction of cytosol to membrane translocation of PKC . - pubmed
[ Recombinant erythropoietin -- a fundamental change in the treatment of anemia ? ] - pubmed
The authors summarize in the submitted review recent findings on erythropoietin ( EPO ) and recombinant EPO ( rHuEPO ) , a new therapeutic preparation which changed fundamentally the clinical picture of many diseases associated with anaemia . - pubmed
The authors discuss the physiology of EPO , regulation of its secretion , mechanism of action on bone marrow and its importance in the pathogenesis of polycythaemia and in particular anaemia . - pubmed
They emphasize in particular the use of rHuEPO in the treatment of different forms of anaemia . - pubmed
They analyze the pathogenesis of renal anaemia and the importance of treatment with rHuEPO for improvement of the haemogram as well as the general condition of the patients , their adaptability , improved psychic condition and reduced need of transfusions . - pubmed
The authors draw attention to the great importance of treatment with rHuEPO in the treatment of anaemias associated with inflammatory diseases ( rheumatoid arthritis , AIDS , Crohn ' s disease and others ) , anaemia associated with malignancies , in the treatment of surgical diseases and in autotransfusions , in anaemias of premature infants and in some congenital heart diseases . - pubmed
The introduction of rHuEPO into the treatment of anaemia is a great advance of modern pharmacotherapy , which moreover opened new vistas on the role of anaemia in the clinical picture of many diseases . - pubmed
A model of prostatic carcinoma tumor kinetics based on prostate specific antigen levels after radiation therapy . - pubmed
Serial prostatic specific antigen values ( PSA ) were determined on 42 patients receiving definitive radiation therapy for localized adenocarcinoma of the prostate . - pubmed
The PSA values after radiation therapy were employed to formulate a model of tumor kinetics . - pubmed
Focal cerebral infarction in cats in the presence of hyperglycemia and increased insulin . - pubmed
We hypothesized that other factors associated with hyperglycemia , such as plasma insulin , may alter the brain 's response to hyperglycemia . - pubmed
The objective of this study was to determine if hyperglycemia changes infarction size following 8 hr of middle cerebral artery occlusion in the anesthetized cat and to examine if changes in plasma insulin levels alter hyperglycemia 's effects . - pubmed
Infarct size in hyperglycemic cats with increased plasma insulin ( 38.3 + /- 8.4 , mean + /- SE ) or in hyperglycemic cats without increased plasma insulin ( 30.5 + /- 7.6 % ) was not significantly different from that of ischemic controls ( 33.8 + /- 2.8 % ) . - pubmed
Glial fibrillary acidic protein in Muller cells has previously been shown to increase after retinal detachment ; here we show that vimentin , another intermediate filament protein present in Muller cells , also increases after detachment . - pubmed
crassiceps induced higher IgG2a than IgG1 levels and 10 - fold lower IgE levels than the natural ip infection ; however , despite the greater IgG2a polyclonal response , anti - parasite antibodies were predominantly of the IgG1 subclass . - pubmed
Evolution of plasma specific fibrin degradation products during thrombolytic therapy in patients with thrombo - embolism . - pubmed
The author is of the opinion that the renin - angiotensin - aldosterone system might be related to these changes during respiratory acidosis . - pubmed
Recently , Fujii and Morita have reported that an increase in plasma renin activity appeared during acute respiratory acidosis . - pubmed
These reports prompted me to question whether the renin - angiotensin - aldosterone system was related to the pathophysiological evidence concerning the respiratory acidosis . - pubmed
Therefore , the purpose of this experiment was to investigate the roles of the renin - angiotensin system and electrolyte metabolism on plasma aldosterone concentration during acute respiratory acidosis . - pubmed
I initiated acute respiratory acidosis with 10 % CO2 inhalation in healthy mongrel dogs , and then plasma aldosterone concentration , plasma renin activity , electrolytes and cardiorenal hemodynamics were measured . - pubmed
The increase of plasma aldosterone concentration was delayed and blurred , in contrast with a significant increase of plasma renin activity , during the acute respiratory acidosis , due to delayed time course of angiotensin II stimulation and also the expected changes in the concentration of angiotensin II receptors on the zona glomerulosa in the adrenal cortex . - pubmed
There was a possibility that the increase in the reabsorption of sodium and water in the proximal tubules , and the increase of ADH secretion during the acute respiratory acidosis , could be related to a decrease in excreted sodium and potassium as well as urine volume . - pubmed
These results suggest that the changes of plasma aldosterone concentration may be affected partially by renin - angiotensin system but not by serum potassium , and plasma aldosterone should be a minimal determinant on the electrolyte metabolism during respiratory acidosis with 10 % CO2 inhalation . - pubmed
( iii ) Infected nu / nu mice produced IgM antibody only transiently in the early stage of infection but they did not subsequently show regular IgG antibody production which normally occurred in nu/+ mice . - pubmed
The overall structure of p40 is homologous to that of the mouse Mov-34 gene product , whose gene disruption by proviral integration results in a recessive embryonic lethality . - pubmed
With both types of lymphocytes , the cytotoxicity was partially inhibited by a preincubation of the effector cells with anti - gamma delta antibodies . - pubmed
These results demonstrate that gamma delta lymphocytes can mediate anti - tumour cytotoxicity and NS8 lymphoma line may be representative of the TCR gamma delta CD8 + T cell subpopulation expressing non MHC - restricted cytotoxicity and displaying antitumoral activity . - pubmed
The viral oncogene , v - rel , is a truncated and mutated form of the turkey c - rel gene expressed by reticuloendotheliosis virus , strain T. In this study , we demonstrated that three avian immunoregulatory receptors , major histocompatibility ( MHC ) antigens class I and class II as well as the interleukin-2 receptor ( IL-2R ) , were induced on the surface of splenic tumor cells isolated from chickens infected with reticuloendotheliosis virus , strain T. All cell lines derived from splenic tumors expressed these three proteins . - pubmed
We show that v - rel induced the expression of MHC class II in the avian B - cell lines DT40 and DT95 more rapidly than c - rel and that , several weeks after infection , v - rel induced MHC class II as much as 50 - fold more efficiently than c - rel . - pubmed
These data suggest that during tumor development , v - rel functions to induce ( or suppress ) the expression of genes similarly induced ( or suppressed ) by c - rel . - pubmed
The observations reported in this study are not in agreement with a model in which v - rel promotes tumor development by functioning as a dominant negative mutant of c - rel . - pubmed
In contrast , these findings support the hypothesis that lymphocyte immortalization and tumor development are the result , at least in part , of the capacity of v - rel to function as a dominant positive mutant that induces expression of genes normally regulated by c - rel . - pubmed
In the 20 yr since it was established that impairment of dihydrotestosterone formation is the cause of a rare form of human intersex , a wealth of information has accumulated about the genetics , endocrinology , and variable phenotypic manifestations , culminating in the cloning of cDNAs encoding two 5 alpha - reductase genes and documentation that mutations in the steroid 5 alpha - reductase 2 gene are the cause of 5 alpha - reductase deficiency . - pubmed
It is also imperative to establish whether defects in steroid 5 alpha - reductase 2 , perhaps in the heterozygous state , are responsible for a portion of cases of sporadic hypospadias , to determine whether 5 alpha - reductase plays a role in progesterone action in women , and to elucidate the relation between androgen action and gender role behavior . - pubmed
Differential expression of basic fibroblast growth factor ( bFGF ) in melanocytic lesions demonstrated by in situ hybridization . - pubmed
Basic fibroblast growth factor ( bFGF ) is an angiogenic and mitogenic polypeptide produced by diverse cell types including cell lines derived from malignant melanomas but not from normal melanocytes . - pubmed
However , there is no consensus concerning in vivo expression of bFGF in melanocytic lesions due in part to the small numbers of cases studied to date . - pubmed
To evaluate further the possible differential expression of bFGF in melanocytic lesions , we examined 110 formalin - fixed , paraffin - embedded metastatic and primary invasive melanomas , melanomas in situ , nevi with architectural disorder and cytological atypia , and ordinary benign melanocyte nevi by nucleic acid in situ hybridization . - pubmed
All metastatic and primary invasive melanomas studied expressed bFGF mRNA , whereas melanomas in situ and benign melanocyte nevi were negative . - pubmed
Melanomas in situ with features of tumor regression and a majority of nevi with architectural disorder and cytological atypia also contained bFGF mrNA . - pubmed
Additional mice expressing point mutations in the cytoplasmic enzyme superoxide dismutase ( SOD1 ) , the only known cause of ALS , have proved that disease arises from a toxic property of the mutant enzyme rather than loss of enzymatic activity . - pubmed
TS1 , the CBD , and an IAP agonist peptide ( 4N1 K ) from the CBD of TS1 activate the platelet integrin alphaIIbbeta3 , resulting in platelet spreading on immobilized fibrinogen , stimulation of platelet aggregation , and enhanced tyrosine phosphorylation of focal adhesion kinase . - pubmed
Test bleeds were taken at 21 , 48 , 62 , and 84 days post immunization and the rat sera were analyzed for anti - OVA antibodies by enzyme linked immunosorbent assay ( ELISA ) . - pubmed
Intravenous immune globulin and pseudohyponatremia . - pubmed
Transforming growth factor - beta1 ( TGF - beta1 ) , a key cytokine for control of cell growth , extracellular matrix formation , and inflammation control , is secreted by many cells present in the arteriosclerotic plaque . - pubmed
In conclusion , depression of scavenger receptor function in monocytes by TGF - beta1 in low concentrations reduces foam cell formation . - pubmed
Use of rifabutin with protease inhibitors for human immunodeficiency virus - infected patients with tuberculosis . - pubmed
CONTEXT : Although niacin increases low levels of high - density lipoprotein cholesterol ( HDL - C ) , which frequently accompany diabetes , current guidelines do not recommend use of niacin in patients with diabetes because of concerns about adverse effects on glycemic control ; however , this is based on limited clinical data . - pubmed
MAIN OUTCOME MEASURES : Plasma lipoprotein , glucose , hemoglobin A(1c ) ( HbA ( 1c ) ) , alanine aminotransferase , and uric acid levels ; hypoglycemic drug use ; compliance ; and adverse events , in patients with diabetes vs without who were receiving niacin vs placebo . - pubmed
RESULTS : Niacin use significantly increased HDL - C by 29 % and 29 % and decreased triglycerides by 23 % and 28 % and low - density lipoprotein cholesterol ( LDL - C ) by 8 % and 9 % , respectively , in participants with and without diabetes ( P<.001 for niacin vs placebo for all ) . - pubmed
Corresponding changes in participants receiving placebo were increases of 0 % and 2 % in HDL - C and increases of 7 % and 0 % in triglycerides , and increases of 1 % and 1 % in LDL - C. Glucose levels were modestly increased by niacin ( 8.7 and 6.3 mg / dL [ 0.4 and 0.3 mmol / L ] ; P = .04 and P<.001 ) in participants with and without diabetes , respectively . - pubmed
Levels of HbA(1c ) were unchanged from baseline to follow - up in participants with diabetes treated with niacin . - pubmed
In participants with diabetes treated with placebo , HbA(1c ) decreased by 0.3 % ( P = .04 for difference ) . - pubmed
CONCLUSIONS : Our study suggests that lipid - modifying dosages of niacin can be safely used in patients with diabetes and that niacin therapy may be considered as an alternative to statin drugs or fibrates for patients with diabetes in whom these agents are not tolerated or fail to sufficiently correct hypertriglyceridemia or low HDL - C levels . - pubmed
Bypassing IgE and targeting T cells for specific immunotherapy of allergy . - pubmed
This has led to a growing consensus that plasma total and low - density lipoprotein cholesterol ( LDL - C ) should be reduced to target levels that have been shown in population studies to be associated with low rates of coronary heart disease ( CHD ) . - pubmed
The aim of this study is to clarify whether the activation of a Na (+)/ H (+ ) exchanger ( NHE ) is tightly concerned with neuronal and glial cell injury induced by ischemia using a selective NHE inhibitor , SM-20220 ( N -( aminoiminomethyl )- 1 - methyl-1H - indole-2 - carboxamide methanesulfonate ) . - pubmed
Two hours of hypoxia followed by 24 h of reoxygenation induced lactate dehydrogenase ( LDH ) release , a marker of cell membrane damage , in cultured neurons and glia derived from rats . - pubmed
A standard NHE inhibitor , 5 -( N - ethyl - N - isopropyl )- amiloride , also reduced LDH release in neurons at concentrations of more than 10(-7 ) mol / l. In a rat transient middle cerebral artery occlusion model , intravenous infusion of SM-20220 reduced cerebral infarction when the serum concentration of SM - 20220 was maintained at about 10(-7 ) mol / l. These results suggest that the activation of the NHE plays an important role in ischemic neuronal and glial cell injury , and NHE inhibitor may have good therapeutic value for the treatment of ischemic stroke . - pubmed
Erythropoietin response to anemia among human immunodeficiency virus - infected infants in Malawi . - pubmed
Enhancement of cytarabine sensitivity in squamous cell carcinoma cell line transfected with deoxycytidine kinase . - pubmed
The reason for this is thought to be that in cell lines of solid tumors the expression of cytidine deaminase , an enzyme that degrades cytarabine , is high , whereas the expression of deoxycytidine kinase ( dCK ) , which phosphorylates cytarabine ( a prodrug ) , is weak . - pubmed
METHODS : Human SCC-25 squamous carcinoma cells were transfected by either retroviral vector or adenoviral vector containing DCK gene and were identified for dCK expression by Northern blot analysis . - pubmed
CONCLUSION : The dCK - cytarabine system may be a useful approach for gene therapy of squamous cell carcinomas of the head and neck . - pubmed
Markers of endothelial cell injury and thrombin activatable fibrinolysis inhibitor in nephrotic syndrome . - pubmed
Markers of endothelial cell injury [ thrombomodulin , intracellular adhesion molecule , vascular cell adhesion molecule , thrombin activatable fibrinolysis inhibitor ( TAFI ) , protein Z , vascular endothelial growth factor , markers of thrombin and plasmin generation ] were studied in 22 patients with nephrotic syndrome . - pubmed
All these parameters studied , except protein Z and D - dimers , were significantly higher in patients with nephrotic syndrome , whereas protein Z was significantly lower when compared with the healthy volunteers . - pubmed
None of the endothelial cell markers ( thrombomodulin , P - selectin , E - selectin , intracellular adhesion molecule , vascular cell adhesion molecule ) , thrombin and plasmin generation markers ( thrombin - antithrombin complexes , prothrombin fragments 1 + 2 , plasmin - antiplasmin complexes , D - dimers ) , protein C , protein Z , vascular endothelial growth factor , and TAFI concentration and activity were directly correlated with the level of proteinuria , albumin , cholesterol , triglycerides or creatinine , except significant positive correlations between TAFI activity and serum creatinine , E - selectin and albumin as well as negative correlations between plasmin - antiplasmin complexes and proteinuria . - pubmed
Elevated circulating TAFI antigen and activity might be a new link in the pathogenesis of impaired fibrinolysis and the progression of atherosclerosis in nephrotic syndrome . - pubmed
For LMWH tests of anti - Xa activities may only be necessary during weight adjusted treatment of pregnant women , children , or cases with reduced kidney function ( glomerular filtration rate & lt ; 30 ml / min . ) - pubmed
High glucose levels abolish antiatherosclerotic benefits of ACE inhibition in alloxan - induced diabetes in rabbits . - pubmed
Renin - angiotensin system activation is recognized to play an important role in atherosclerosis . - pubmed
This study aimed to verify the antiatherosclerotic effects of ACE inhibition on an experimental model of diabetes and hypercholesterolemia . - pubmed
Anticardiolipin and anti - beta2 glycoprotein I antibodies in infants born to mothers with antiphospholipid antibody - positive autoimmune disease : a follow - up study . - pubmed
Infants born from mothers with antiphospholipid antibody ( aPL ) -positive autoimmune disease were prospectively evaluated for anticardiolipin and anti - beta2 glycoprotein I antibodies ( group 1 ) and for growth and neurological development . - pubmed
The negativity of anticardiolipin in all infants at 12 months suggests that anticardiolipin detection is the best assay to evaluate the disappearance of maternal aPL and to estimate the potential risk of thrombosis associated with these antibodies . - pubmed
Here we describe a new approach for visualizing tumors whose fluorescence can be detected using telomerase - specific replication - competent adenovirus expressing green fluorescent protein ( GFP ) ( OBP-401 ) . - pubmed
The human epidermal growth factor receptor 2 ( HER2 ) is a member of the epidermal growth factor receptor ( EGFR ) family , and it plays an important role in the development of many human adenocarcinomas . - pubmed
Comparison of apolipoprotein B and non - high - density lipoprotein cholesterol for identifying coronary artery disease risk based on receiver operating curve analysis . - pubmed
Histone deacetylase inhibitors exhibit anti - inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke : multiple mechanisms of action . - pubmed
The present study employed a rat permanent middle cerebral artery occlusion ( pMCAO ) model to study effects of histone deacetylase ( HDAC ) inhibition on ischemia - induced brain infarction , neuroinflammation , gene expression , and neurological deficits . - pubmed
Moreover , injections with HDAC inhibitors superinduced heat - shock protein 70 and blocked pMCAO - induced down - regulation of phospho - Akt , as well as ischemia - elicited up - regulation of p53 , inducible nitric oxide synthase , and cyclooxygenase-2 . - pubmed
Together , our results demonstrate robust neuroprotective effects of HDAC inhibitors against cerebral ischemia - induced brain injury . - pubmed
Given that there is no effective treatment for stroke , HDAC inhibitors , such as VPA , SB , and TSA , should be evaluated for their potential use for clinical trials in stroke patients . - pubmed
In this study , we determined the in vitro effect of peroxisome proliferator - activated receptor - gamma ( PPAR - gamma ) activation on the aortic relaxation , lipolysis and insulin - induced [ ( 3 ) H ]- glucose uptake of the abdominal ( omental ) adipocytes of the non - diabetic ( + db/+m ) and obese / diabetic ( + db/+db ) mice . - pubmed
Beckwith Wiedemann syndrome ( BWS ) and Russell Silver syndrome ( RS ) are growth disorders with opposing epimutations affecting the H19 / IGF2 imprinting center at 11p15.5 . - pubmed
Overgrowth and tumor risk in BWS is caused by aberrant expression of the paternally expressed , imprinted IGF2 gene , occurring as a consequence of mosaic hypermethylation within the imprinting center , or to mosaic paternal uniparental disomy ( UPD ) . - pubmed
A subset of RS cases were recently shown to have mosaic hypomethylation within the H19 / IGF2 imprinting center , predicted to silence paternally expressed IGF2 in early development . - pubmed
Molecular diagnosis for BWS and RS involves methylation analysis of the H19 locus , enabling discrimination of allelic methylation patterns . - pubmed
We conclude that MS - HRM is a rapid , cost - effective , and sensitive method for screening mosaic methylation changes at the H19 locus in BWS and RS . - pubmed
CONCLUSIONS : Adolescent HAP1 mice appear to be more vulnerable to the effects of footshock stress than adult mice , as manifested by increased alcohol drinking and anxiety - related behavior in adulthood . - pubmed
A CACNB4 mutation shows that altered Ca ( v ) 2.1 function may be a genetic modifier of severe myoclonic epilepsy in infancy . - pubmed
Mutations of SCN1A , encoding the voltage - gated sodium channel alpha1 subunit , represent the most frequent genetic cause of severe myoclonic epilepsy in infancy ( SMEI ) . - pubmed
All coding exons of SCN1B , GABRG2 , and CACNB4 genes were screened for mutations in 38 SCN1A - mutation - positive SMEI probands . - pubmed
Moreover , colonic ulceration , leukocytic infiltration , and cytokine levels ( TNF - alpha and IL-6 ) were also decreased in the colons of herbal - treated mice , reflected by H & amp ; E staining , MPO assay , and cytokine ELISA . - pubmed
Myeloperoxidase ( MPO)-specific antineutrophil cytoplasmic antibodies have been proposed as pathogenic for microscopic polyangiitis . - pubmed
Supporting this hypothesis , a case report of transplacental anti - MPO antibody transfer presumably causing a vasculitis - like syndrome in the newborn is cited frequently . - pubmed
5 - hydroxytryptamine ( 5 - HT )( 1A ) receptors are known to play a pivotal role in the 5 - HTergic mechanisms associated with the etiology of stress - related disorders . - pubmed
A recent report in the New England Journal of Medicine on the early clinical evaluation of Olaparib in cancers lacking the BRCA1 or BRCA2 genes exemplifies this promising new trend . - pubmed
Melanoma hyperpigmentation is strongly associated with KIT alterations . - pubmed
KIT alterations have been identified in melanoma and treatment with imatinib has met with some success . - pubmed
However , the relationship between KIT and melanoma histology remains uncharacterized , and its role in melanoma pathogenesis unknown . - pubmed
Cases were analyzed for KIT protein expression relative to histologic variables : subtype , sun damage , tumor infiltrating lymphocytes , melanoma in situ , vertical growth phase ( VGP ) , location , and hyperpigmentation . - pubmed
Although KIT mutations were uncommon overall , pigmentation in conjunction with immunohistochemistry and nodular growth phase raised their frequency to 2 ( 40 % ) of 5 cases . - pubmed
We expand the context of KIT aberrations to involve areas other than acral and mucosal sites and demonstrate an inverse relationship between KIT abnormalities and sun damage . - pubmed
There is a strong correlation to hyperpigmentation that overrides factors including sun damage , tumor location , and histologic subtype , which may be used to identify cases with KIT aberrations . - pubmed
In conclusion , cell apoptosis and G(2 ) phase arrest mediated by Cdc25C , Cdc2 and cyclinB1 may be the initiating event in the gastric toxicity of OTA . - pubmed
A total of 50 consecutive patients ( median age , 57.5 years ) with AML ( n=30 ) or myelodysplasia ( MDS , n=20 ) underwent HLA matched related donor ( MRD , n=27 ) or unrelated donor ( MUD , n=23 ) peripheral blood hematopoietic cell transplantation after nonmyeloablative CY / fludarabine ( Flu ) conditioning . - pubmed
Of 14 survivors with cGVHD , 5 ( 35.7 % ) experienced resolution off immunosuppression , suggesting that tolerance with HLA matched grafts is possible at an advanced age by this method . - pubmed
The neurological impairment was regressive within 6 months after intravenous immunoglobulin treatment followed by intravenous then oral corticosteroid administration . - pubmed
Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors : a study of 305 cases . - pubmed
Brachyury is recognized as a specific marker for notochord - derived tissues and neoplasms , and has become a defining immunohistochemical feature of chordoma . - pubmed
The main differential diagnostic consideration for chordoma is chondrosarcoma , which is known to lack brachyury expression . - pubmed
Although immunoreactivity for brachyury has been reported in a few germ cell tumors , a thorough characterization of staining by specific subtype has not been performed in a large series . - pubmed
Additionally , brachyury expression in clear cell renal cell carcinoma has not been well studied . - pubmed
In this study , immunohistochemical expression with the brachyury antibody was evaluated in 111 germ cell tumors , 30 non - neoplastic and neoplastic ( non - germ cell ) testicular tissues , and 184 metastatic clear cell renal cell carcinomas using tissue microarray technology . - pubmed
In addition , immunoreactivity for PAX-8 and SALL-4 was evaluated in 12 chordomas on whole section . - pubmed
No nuclear brachyury expression was identified in any of the 101 germ cell tumors within the tissue microarray ( including choriocarcinoma ( 1 ) , embryonal carcinoma ( 20 ) , intratubular germ cell neoplasia unclassified ( 2 ) , seminoma ( 64 ) , spermatocytic seminoma ( 1 ) , teratoma ( 5 ) and yolk sac tumor ( 8) ) , in any of the 30 non - neoplastic and neoplastic ( non - germ cell ) testicular tissues , or in any of the 10 whole - section seminomas . - pubmed
All 184 metastatic clear cell renal cell carcinomas were also non - reactive for brachyury . - pubmed
All 12 chordomas showed strong nuclear immunoreactivity for brachyury , but no expression of SALL-4 . - pubmed
In all , 1 of 12 chordoma cases showed patchy , 1 + nuclear immunoreactivity for PAX-8 . - pubmed
This study confirms the specificity of brachyury for chordoma in the differential diagnostic distinction from the potential genitourinary mimics , germ cell tumors and metastatic clear cell renal cell carcinoma . - pubmed
Observed and predicted total pubertal growth during treatment with growth hormone in adolescents with idiopathic growth hormone deficiency , Turner syndrome , short stature , born small for gestational age and idiopathic short stature : KIGS analysis and review . - pubmed
Mutations in the p53 Tumor Suppressor Gene : Important Milestones at the Various Steps of Tumorigenesis . - pubmed
Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis . - pubmed
In most cases , the p53 gene is mutated , giving rise to a stable mutant protein whose accumulation is regarded as a hallmark of cancer cells . - pubmed
Mutant p53 proteins not only lose their tumor suppressive activities but often gain additional oncogenic functions that endow cells with growth and survival advantages . - pubmed
Interestingly , mutations in the p53 gene were shown to occur at different phases of the multistep process of malignant transformation , thus contributing differentially to tumor initiation , promotion , aggressiveness , and metastasis . - pubmed
Here , the authors review the different studies on the involvement of p53 inactivation at various stages of tumorigenesis and highlight the specific contribution of p53 mutations at each phase of cancer progression . - pubmed
Caspase inhibitors also altered cellular ultrastructure , resulting in features suggestive of necrosis rather than apoptosis . - pubmed
The Gln1233ter mutation of the myosin binding protein C gene : causative mutation or innocent polymorphism in patients with hypertrophic cardiomyopathy ? - pubmed
To investigate the individual and combined roles of NDST1 and NDST2 during MC development , in vitro differentiated MCs derived from mouse embryos and embryonic stem cells , respectively , have been studied . - pubmed
Depression is characterized by aberrations in six intertwined pathways : ( 1 ) inflammatory pathways as indicated by increased levels of proinflammatory cytokines , e.g. - pubmed
GSK-3 inhibitors have antidepressant effects in animal models of depression . - pubmed
MARK pathway , TGFbeta pathway and cell cycle ) Through the investigation on methylation , we found that most of the CRC related genes and miRNAs were prone to be regulated by methylation . - pubmed
We conducted a cross - sectional study and assessed the association of the methylenetetrahydrofolate reductase ( MTHFR ) C677 T variant with features of MetS in SGA - treated ( n=105 ) and SGA - naive ( n=112 ) children . - pubmed
We targeted the MTHFR C677 T variant , because it is associated with risk for cardiovascular disease , and features of MetS in adults without psychiatric illness . - pubmed
MetS in children is based on the presence of any three of the following : waist circumference & gt;= 90th percentile for age and sex ; plasma triglyceride & gt;= 1.24 mmol l(-1 ) ; plasma high - density lipoprotein - cholesterol & lt;= 1.03 mmol l(-1 ) ; systolic or diastolic blood pressure & gt;= 90th percentile for age , sex , and height ; and fasting glucose & gt;= 5.6 mmol l(-1 ) . - pubmed
The MTHFR 677 T allele was associated ( P<0.05 ) with MetS ( OR 5.75 , 95 % CI= 1.18 - 28.12 ) in SGA - treated children . - pubmed
These findings illustrate the high prevalence of MetS in SGA - treated children and suggest metabolic alterations associated with the MTHFR C677 T variant may have a role in the development of MetS features in SGA - treated children . - pubmed
RESULTS : IP applied alone caused a mild pancreatic damage associated with a limited increase in plasma amylase activity , concentration of pro - inflammatory interleukin-1beta and plasma level of D - dimer . - pubmed
Both these procedures caused a similar reduction in plasma lipase , amylase and interleukin-1beta , as well as in histological signs of pancreatic damage . - pubmed
It was manifested by an increase in pancreatic damage and plasma level of lipase , amylase and interleukin-1beta , as well as by reduction in pancreatic DNA synthesis and plasma concentration of D - dimer and interleukin-10 . - pubmed
We suggest that the combination of abhorrent UPR signaling , promotion of cell death , and increased innate immune responses contributes to the replication defects in ATF6 - deficient cells , thus demonstrating the dual importance of ATF6 in maintaining cell viability and modulating immune responses during WNV ( KUN ) infection . - pubmed
The transcription factor Fosl1 plays a key role in the vasculogenic and angiogenic processes as Fosl1 knockout embryos die with vascular defects in extraembryonic tissues . - pubmed
In a T47D cell - based reporter assay , 1 and 2 potently inhibited hypoxia - induced HIF-1 activation ( IC50 values 0.18 and 1.10 mugmL(-1 ) , respectively ) . - pubmed
One surprising observation was that , while less potent , the purported cancer chemopreventive agent auraptene ( 8) was found to act as a mitochondrial poison that disrupts HIF-1 signaling in tumors . - pubmed
To evaluate their anti - allergic inflammatory activities , the inhibitory effects of isolates ( 1 - 7 ) on histamine release and on the gene expressions of tumor necrosis factor ( TNF )- a and interleukin ( IL )- 6 were examined using human mast cells ; previous studies have reported that TNF - alpha and IL-6 release from mast cells is positively related to the severity of allergic symptoms . - pubmed
obtusiloba inhibit mast - cell - derived allergic inflammation , histamine , and proinflammatory cytokines . - pubmed
A Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with BRAF K601E Mutation and Three Conventional Types with BRAF V600E Mutation . - pubmed
This case genetically demonstrates unique features including the simultaneous presence of the BRAF V600E ( T1799A ) mutation and the BRAF K601E ( A1801 G ) mutation in conventional PTC and FVPTC , respectively . - pubmed
Regulation of the V - ATPase by AMPK may couple V - ATPase activity to cellular metabolic status with potential relevance to ischemic injury in the kidney and other tissues . - pubmed
TOX3 mutations in breast cancer . - pubmed
TOX3 maps to 16q12 , a region commonly lost in breast cancers and recently implicated in the risk of developing breast cancer . - pubmed
However , not much is known of the role of TOX3 itself in breast cancer biology . - pubmed
This is the first study to determine the importance of TOX3 mutations in breast cancers . - pubmed
We screened TOX3 for mutations in 133 breast tumours and identified four mutations ( three missense , one in - frame deletion of 30 base pairs ) in six primary tumours , corresponding to an overall mutation frequency of 4.5 % . - pubmed
Whilst copy number changes of 16q12 are common in breast cancer , our data show that mutations of TOX3 are present at low frequency in tumours . - pubmed
Our results support that TOX3 should be further investigated to elucidate its role in breast cancer biology . - pubmed
[ Associations of ulcerative colitis with vitamin D receptor gene polymorphisms and serum levels of 25 - hydroxyl vitamin D ] . - pubmed
OBJECTIVE : To explore the associations of ulcerative colitis ( UC ) with vitamin D receptor ( VDR ) gene polymorphisms and serum levels of 25 - hydroxyl vitamin D[25 ( OH ) D ] . - pubmed
The frequencies of minor allele and genotype of VDR were compared between UC patients and the controls by chi(2 ) test and Bonferroni correction . - pubmed
RESULTS : After Bonferroni correction , mutant allele and genotype frequencies of VDR ( Fok I , Bsm I , Apa I , Taq I ) did not statistically differ between UC patients and the controls ( all P & gt ; 0.012 5 ) . - pubmed
Stratification by the Truelove & amp ; Witts severity index , mutant allele ( C ) and genotype ( TC+CC ) of VDR(Fok I ) were significantly higher in patients with mild and moderate UC than in those with severe UC ( 54.37 % ( 373/686 ) vs 37.70 % ( 46/122 ) , 81.92 % ( 281/343 ) vs 55.74 % ( 34/61 ) , both P & lt ; 0.01 ) . - pubmed
By linear regression analysis , the serum levels of 25 ( OH ) D in UC patients were independently and positively correlated with hemoglobin ( beta = 0.499 , P & lt ; 0.01 ) and yet independently and negatively correlated with C - reaction protein ( beta = -0.346 , P & lt ; 0.01 ) and white blood cells ( beta = -0.291 , P = 0.002 ) . - pubmed
Using Logistic regression analysis , it was found that mutant genotype ( GA / AA ) of VDR ( Bsm I ) played an independently protective role in UC ( OR = 0.328 , P = 0.028 ) while mutant genotype ( TC / CC ) of VDR ( Fok I ) and vitamin D deficiency ( & lt;50.0 nmol / L ) had an interaction in UC ( OR = 2.070 , P = 0.006 ) . - pubmed
CONCLUSIONS : Genetic polymorphism of VDR ( Fok I , Bsm I , Apa I , Taq I ) and serum levels of 25 ( OH ) D are significantly correlated with UC . - pubmed
Mutation of VDR ( Bsm I ) is a protective factor for UC . - pubmed
Moreover , mutant genotype ( TC / CC ) of VDR ( Fok I ) and vitamin D deficiency may exert synergistic effects on the susceptibility to UC . - pubmed
PATIENTS AND METHODS : Immunohistochemical profiles of HPV - related cell cycle markers , including p16 , pRb , cyclin D1 , p53 , and the HPV DNA status of 42 consecutive TSCC patients who underwent TLO - based treatments were analyzed . - pubmed
RESULTS : Univariate analysis indicated that high p16 , low pRb , and low p53 expression levels are significantly associated with a good disease - free and overall survival outcome . - pubmed
High expression of erythropoietin - producing hepatoma cell line - B2 ( EphB2 ) predicts the efficiency of the Qingyihuaji formula treatment in pancreatic cancer CFPAC-1 cells through the EphrinB1 - EphB2 pathway . - pubmed
Our previous study demonstrated that inhibition of erythropoietin - producing hepatoma cell line - B2 ( EphB2 ) expression resulted in the promotion of cancer growth , with EphB2 acting as a tumor suppressor in pancreatic cancer . - pubmed
In the current study , the different effects on tumor growth inhibition following QYHJ treatment in cells with different levels of EphB2 expression were investigated to reveal the mechanism . - pubmed
A subcutaneously transplanted tumor model using cancer cells with different levels of EphB2 expression were established in vivo and received a four - week QYHJ intervention . - pubmed
The results showed that the tumor weight inhibitory rate was 31.40 , 31.33 and 18.36 % in CFPAC-1 , CFPAC-1 control RNAi and CFPAC-1 EphB2 RNAi cells following QYHJ treatment , respectively . - pubmed
Therefore , EphB2 acts as a predictive factor for QYHJ treatment in pancreatic cancer CFPAC-1 cells . - pubmed
We apply SigFuge to RNA - seq cohorts of 177 lung and 279 head and neck squamous cell carcinoma samples from the Cancer Genome Atlas , and identify several cases of differential isoform usage including CDKN2A , a tumor suppressor gene known to be inactivated in a majority of lung squamous cell tumors . - pubmed
For the first time , we here report exonic deletions of CTNND2 causing low normal IQ with learning difficulties with or without autism spectrum disorder . - pubmed
PATIENTS : Men who presented for endocrine evaluation from 2011 to 2014 with testosterone levels & lt;10.4 nmol / L ( 300 ng / mL ) , normal LH and FSH levels and no known pituitary disease . - pubmed
Sex differences in glutamate receptor gene expression in major depression and suicide . - pubmed
CD19+CD24hiCD38hiBregs involved in downregulate helper T cells and upregulate regulatory T cells in gastric cancer . - pubmed
We characterized the role of Bregs in the progression of gastric cancer . - pubmed
We detected an increase in Bregs producing IL-10 both in peripheral blood mononuclear cells ( PBMCs ) and in gastric tumors . - pubmed
Collectively , these findings demonstrate that increased Bregs play a immunosuppressive role in gastric cancer by inhibiting T cells cytokines as well as conversion to Tregs . - pubmed
The disease is characterized by type 1 hypersensitivity to fungal allergens , dramatically elevated total serum IgE , accumulation of thick eosinophil - laden mucin with non - invasive fungal hyphae within the paranasal sinuses , nasal polyposis , and sinus bony remodeling . - pubmed
This study was designed to compare effectiveness and safety of warfarin , direct thrombin inhibitor dabigatran , Xa factor inhibitors rivaroxaban and apixaban used to prevent stroke in 280 elderly patients in patients with age - specific non - valvular atrial fibrillation . - pubmed
Hemoglobin A1c is the measurement of glycated hemoglobin and can aid in both the diagnosis and continued management of diabetes mellitus . - pubmed
Accurate glycosylated hemoglobin A1c ( A1c ) measurements are an essential part of decision making in the diagnosis and treatment of type 2 diabetes mellitus . - pubmed
Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome : comment . - pubmed
Recombinase polymerase amplification ( RPA ) has emerged as a novel isothermal amplification technology for the molecular diagnosis of infectious diseases . - pubmed
In this in vitro experiment , we obtained RAW264.7 macrophages and human peripheral blood mononuclear cells ( PBMCs ) incubated by LPS or plasma from septic patients to explore the NF - kappaB pathway in the effect of the inhalation of sevoflurane combined with oxygen in sepsis . - pubmed
We also founded that 0.5 MAC of sevoflurane in 60 % oxygen inhibited the nuclear translocation of NF - kappaB in human PBMCs induced by LPS or plasma from septic patients . - pubmed
The subanesthesia dose sevoflurane in 60 % oxygen may reduce sepsis - induced inflammatory responses in animals and in PBMCs , and the inhibition to the activation of the NF - kappaB pathway may contribute to this protection . - pubmed
EGFR Mutation Status in Lung Adenocarcinoma - Associated Malignant Pleural Effusion and Efficacy of EGFR Tyrosine Kinase Inhibitors . - pubmed
The aim of this study was to investigate epidermal growth factor receptor ( EGFR ) mutation status in lung adenocarcinoma - associated MPEs ( LA - MPEs ) and its correlation with efficacy of EGFR tyrosine kinase inhibitor ( TKI ) therapy . - pubmed
Materials and Methods : Samples comprised 40 cell blocks of pathologically - confirmed LA - MPEs collected before the start of EGFR TKI therapy . - pubmed
The objective response rate ( ORR ) of 26 patients with EGFR mutations in LA - MPEs among the 36 patients with measurable lesions was 80.8 % , while the ORR of the 10 patients with wild - type EGFR in LA - MPEs was 10 % ( p & amp;lt ; 0.001 ) . - pubmed
Among the 26 patients with EGFR mutations in LA - MPEs , the ORR of target lesions and LA - MPEs were 88.5 % and 61.5 % , respectively ( p=0.026 ) . - pubmed
Conclusion : EGFR mutation status in cell blocks of LA - MPEs confirmed by pathologic diagnosis is highly predictive of EGFR TKI efficacy . - pubmed
For patients with EGFR mutations in LA - MPEs , the response to EGFR TKIs seems to be worse for pleural effusions than for solid tumors . - pubmed
Characterization of the LECT2 gene and its protective effects against microbial infection via large lymphocytes in Lampetra japonica . - pubmed
Leukocyte cell - derived chemotaxin 2 ( LECT2 ) is a multifunctional protein of the innate immune system that defends against bacterial infections and chemotactic activity . - pubmed
A study of serum vascular endothelial growth factor in infantile hemangiomas . - pubmed
Aims : To study the clinicoepidemiological profile of infantile hemangiomas , to estimate and compare the serum levels of VEGF in infantile hemangiomas and controls , and to determine correlations between serum levels of VEGF and growth characteristics of infantile hemangiomas . - pubmed
There were no statistically significant correlations between serum VEGF levels and sex or size , phase of growth , morphological variants or ulceration of lesions . - pubmed
Conclusions : The mean value of serum VEGF in the study group was significantly higher than that in the control group , suggesting that serum VEGF can serve as a diagnostic marker of infantile hemangiomas . - pubmed
Mean serum VEGF was higher in proliferative lesions than in involuting lesions , indicating that it may also be useful as a prognostic serological marker in cases of infantile hemangioma . - pubmed
Electron microscopy analysis of human tissue samples with necrotizing fasciitis confirmed increased C4BP binding to S. - pubmed
In vivo studies reveal that IrM2 can significantly inhibit tumor growth in a mouse model . - pubmed
Abstract : Cyclin D1 is linked with the development and progression of oral squamous cell carcinoma ( OSCC ) . - pubmed
This case - control study was directed to characterise the immunoreactivity of the protein cyclin D1 and its correlation with the clinicopathological parameters of patients with OSCC and potentially malignant disorders ( PMD ) . - pubmed
A group of patients with OSCC were followed up after treatment , and the cyclin D1 expression was reviewed for correlation of cyclin D1 expression with prognosis of the patients . - pubmed
Results : Age , gender and site showed no statistically significant correlation with cyclin D1 expression in OSCC and PMD . - pubmed
The cyclin D1 score did not show a significant difference with histopathological diagnosis of OSCC . - pubmed
Cyclin D1 was not expressed in 60 % of the Control and 30 % PMD cases while the expression of cyclin D1 was seen in 100 % of OSCC cases although cyclin D1 score did not show a statistically significant association in the prognosis of the disease among the OSCC patients . - pubmed
Echocardiographic analyses showed that , compared with wild - type infarcted control mice , AID-/-muS-/- mice exhibited improved cardiac function and reduced remodeling on day 56 post - MI . - pubmed
An unbiased screening of the heart reactivity potential in the plasma of wild - type MI animals revealed the presence of antibodies that target the myocardial scar and collagenase - sensitive epitopes . - pubmed
Phosphatidylinositol 3 - kinase delta pathway : a novel therapeutic target for Sjogren ' s syndrome . - pubmed
BACKGROUND : The phosphatidylinositol 3 - kinase delta isoform ( PI3Kdelta ) belongs to an intracellular lipid kinase family that regulate lymphocyte metabolism , survival , proliferation , apoptosis and migration and has been successfully targeted in B - cell malignancies . - pubmed
Given the central role of B cells in pSS pathogenesis , we investigated PI3Kdelta pathway activation in pSS and the functional consequences of blocking PI3Kdelta in a murine model of focal sialoadenitis that mimics some features of pSS . - pubmed
METHODS AND RESULTS : Target validation assays showed significant expression of phosphorylated ribosomal protein S6 ( pS6 ) , a downstream mediator of the phosphatidylinositol 3 - kinase delta ( PI3Kdelta ) pathway , within pSS salivary glands . - pubmed
In vivo blockade of PI3Kdelta activity with seletalisib , a PI3Kdelta - selective inhibitor , in a murine model of focal sialoadenitis decreased accumulation of lymphocytes and plasma cells within the glands of treated mice in the prophylactic and therapeutic regimes . - pubmed
CONCLUSION : These data demonstrate activation of PI3Kdelta pathway within the glands of patients with pSS and its contribution to disease pathogenesis in a model of disease , supporting the exploration of the therapeutic potential of PI3Kdelta pathway inhibition in this condition . - pubmed
The Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk ( FOURIER ) and Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab ( ODYSSEY OUTCOMES ) studies , with the two available PCSK9 antagonists , i.e. - pubmed
Interest has been expanded to areas not only limited to low - density lipoprotein cholesterol reduction but also investigating other non - lipid pathways raising cardiovascular risk , in particular inflammation associated to raised high - sensitivity C - reactive protein levels , not significantly affected by the present PCSK9 antagonists . - pubmed
We identified adult patients with muscle injury from ICD-10AM codes , serum creatine kinase level greater than 1000 U / ml , and a clinical history consistent with rhabdomyolysis . - pubmed
Compared to the rest of the cohort , patients who used illicit drugs were younger and had higher peak serum creatinine kinase , and developed a higher severity of acute kidney injury . - pubmed
In multivariable analysis , the factors associated with acute kidney injury were illicit drug use , peak creatine kinase , cardiovascular disease , concurrent sepsis and a clinically - evident pressure injury . - pubmed
CONCLUSIONS : Illicit drug use was associated with acute kidney injury and renal replacement therapy independent of creatine kinase levels . - pubmed
Mean Urine albumin - to - creatinine ratio ( UACR ) was 0.02 , and 166 subjects showed significant albuminuria ( UACR & gt;= 0.03 ) . - pubmed
Expanding the phenotypic spectrum of Allan - Herndon - Dudley syndrome in patients with SLC16A2 mutations . - pubmed
The aim of the study was to redefine the phenotype of Allan - Herndon - Dudley syndrome ( AHDS ) , which is caused by mutations in the SLC16A2 gene that encodes the brain transporter of thyroid hormones . - pubmed
WHAT THIS PAPER ADDS : Mild intellectual disability is associated with SLC16A2 mutations . - pubmed
Patients with SLC16A2 mutations present a broad spectrum of neurological phenotypes that are also observed in other hypomyelinating disorders . - pubmed
The macrosomia rate was higher in the glibenclamide - exposed group than the insulin - alone group ( 12.2 % vs 0 % , P=0.025 ) . - pubmed
In a low-/middle - income country setting with a high prevalence of HIV and high usage of OHAs as an alternative to insulin therapy , HIV might be associated with higher PNM and glibenclamide with increased rates of macrosomia , which warrants further exploration . - pubmed
Here , we show that intravenously injected carbon quantum dots , functionalized with multiple paired alpha - carboxyl and amino groups that bind to the large neutral amino acid transporter 1 ( which is expressed in most tumours ) , selectively accumulate in human tumour xenografts in mice and in an orthotopic mouse model of human glioma . - pubmed
High shear stress in the mechanical device results in acquired von Willebrand syndrome ( AVWS ) , characterized by a loss of high - molecular - weight multimers of von Willebrand factor ( VWF ) leading to an increased bleeding risk . - pubmed
Etiological models for AVWS are increased cleavage by the metalloproteinase ADAMSTS13 , mechanical destruction of VWF , and shear - induced VWF binding to platelets . - pubmed
AVWS can be diagnosed by detection of VWF multimers using gel - electrophoresis and functional assays of varying sensitivity ( VWF ristocetin cofactor activity , VWF activity , VWF collagen binding ) . - pubmed
Glucagon like peptide-2 for Intestinal stem cell and Paneth cell repair during graft - versus - host disease in mice and humans . - pubmed
We observed that acute GVHD reduced intestinal GLP-2 levels in mice and patients developing GVHD . - pubmed
Treatment with the GLP-2 agonist , teduglutide , reduced de novo acute GVHD and steroid - refractory GVHD , without compromising graft - versus - leukemia ( GVL ) effects in multiple mouse models . - pubmed
Our findings indicate that L - cells are a target of GVHD and that GLP-2 - based treatment of acute GVHD restores intestinal homeostasis via an increase of ISCs and PCs without impairing GVL effects . - pubmed
Angiotensin - converting enzyme 2 ( ACE2 ) has been identified as the functional receptor of severe acute respiratory syndrome coronavirus 2 ( SARS - CoV-2 ) and a target for disease prevention . - pubmed
However , the relationship between ACE2 expression and its clinical implications in SARS - CoV-2 pathogenesis remain unknown . - pubmed
Glucose oxidase ( GOx)-mediated starvation therapy has demonstrated good application prospect in cancer treatment . - pubmed
The modification of HA on Pd@Pt - GOx could block the GOx activity , catalase ( CAT)-like and peroxidase ( POD)-like activities of Pd@Pt , reduce the cytotoxicity to normal cells and organs , and effectively target CD44 - overexpressed tumors by active targeting and passive enhanced permeability and retention ( EPR ) effect . - pubmed
Meanwhile , the upregulated acidity and H2O2 content in the tumor region generated by GOx catalytic oxidation of glucose dramatically facilitated the pH - responsive POD - like activity of the Pd@Pt nanozyme , which then catalyzed degradation of the H2O2 to generate abundant highly toxic OH , thereby realizing nanozyme - mediated starving - enhanced chemodynamic cancer therapy . - pubmed
Molecular subtype - specific responses of colon cancer cells to the SMAC mimetic Birinapant . - pubmed
Due to the multiple molecular mechanisms - of - action of these targets , responses to IAP antagonist may differ between molecularly distinct colon cancer cells . - pubmed
In this study , responses to the IAP antagonist Birinapant and oxaliplatin/5 - fluorouracil ( 5 - FU ) were investigated in 14 colon cancer cell lines , representing the consensus molecular subtypes ( CMS ) . - pubmed
Collectively , our study demonstrates that IAP inhibition is a promising modulator of response to oxaliplatin/5 - FU in colorectal cancers of the CMS1 subtype , and may show promise as in the CMS2 subtype , suggesting that molecular subtyping may aid as a patient stratification tool for IAP antagonists in this disease . - pubmed
Endoplasmic reticulum aminopeptidase 2 , ERAP2 , is an emerging pharmacological target in cancer immunotherapy and control of autoinflammatory diseases , as it is involved in antigen processing . - pubmed
CONCLUSIONS : The comorbidity of malaria and intestinal helminths causes lower hemoglobin level leading to maternal anemia , preterm delivery , and still birth in pregnant women and lactating mother . - pubmed
Complexes of breast - cancer - associated antigen ( s ) and corresponding antibodies in pleural effusions from a patients with breast cancer . - pubmed
[ Liver and serum alkaline phosphatase in cancer of the gastrointestinal tract ] . - pubmed
CD5 - negative cell mediated experimental hypersensitivity pneumonitis . - pubmed
This work confirms the loss of HRAS alleles in 1 out of 2 cases of invasive ovarian cancer as determined in 32 samples or cell lines derived from 19 patients . - pubmed
Infection specific prion protein ( PrP ) accumulates on neuronal plasmalemma in scrapie infected mice . - pubmed
Prion protein ( PrP ) is an abundant membrane - associated host protein which accumulates in abnormal , relatively protease - resistant forms in the brains of animals with scrapie and related diseases . - pubmed
Using correlative light and electron microscopy we determined the sites of subcellular localisation of PrP in mice infected with the 87V strain of scrapie . - pubmed
Moreover , the absence of a specific IgE response or of particulate masses of Ig or complement , made it unlikely an anaphylactoid or Arthus - type reaction could have been responsible . - pubmed
It is concluded that those with frequent occupational exposure to M tuberculosis have larger numbers of circulating T cells reactive with mycobacterial antigens , so that the development of the skin test response to tuberculin is less dependent on " by - stander " cell infiltration to mediate the delayed hypersensitivity reaction than the reactions in those with less intense and less frequent natural exposure . - pubmed
One year later , it was revealed that she suffered from ATL , confirmed by the presence of ATL cells in peripheral blood and anti - ATLA antibody . - pubmed
In both cases the nature of the hepatic lesion was already clear before biopsy , from characteristic ultrasound , CT - scan , and a progressive rise in CEA levels . - pubmed
The role of histamine in cardiac anaphylaxis ; characterization of histaminergic H1 - and H2 - receptor effects . - pubmed
In addition , serum from those with larger burns caused a marked reduction in the interleukin-2 receptor - labeling index , suggesting that it possesses factor(s ) that directly or indirectly block T lymphocyte interleukin-2 receptor expression . - pubmed
Modified responsiveness of v - Ha - ras - transfected rat fibroblasts to growth factors and a tumor promoter . - pubmed
The correlation of the phenotypic changes of v - Ha - ras transfected cells with the expression of p21ras and the modified responses to growth factors and a tumor promoter were examined . - pubmed
A tumor promoter , 12 - O - tetradecanoylphorbol-13 - acetate ( TPA ) also augmented anchorage - independent growth of ras - transformed cells and induced morphological changes in monolayer cultures without altering the expression of the ras gene or phosphorylation of the p21ras protein . - pubmed
Transplantation of a large inoculum of incubated islets of MHC - compatible donors led to an extended survival of the grafts to an average of greater than 86 days in 71 % of male diabetic BB / W recipients . - pubmed
Long - lasting prolactin - lowering effect of cabergoline , a new dopamine agonist , in hyperprolactinemic patients . - pubmed
After cabergoline treatment , serum GH levels did not change significantly in either nonacromegalic or acromegalic patients , whereas the two dopamine - responsive acromegalic patients had a marked GH fall after bromocriptine . - pubmed
Thirty - three out of 133 children ( 24.8 % ) tested for serum HBsAg were found positive : 26 ( 78.7 % ) of them developed chronic hepatitis . - pubmed
Anthropometric parameters -- weight loss , arm muscle circumference , skin - fold thickness -- and biochemical parameters -- serum albumin and delayed cutaneous hypersensitivity reactions to purified protein derivative ( PPD ) and phytohemagglutinin ( PHA)--were used for nutritional assessment . - pubmed
Ca2 + -dependence of thrombin - induced aggregation and MDA formation , and Ionophore A23187 - induced aggregation of the platelets from SHRSP at a hypertensive age(16 - weeks ) was similar to that of the aggregation of platelets from age - matched WKY . - pubmed
These results suggest that abnormalities of SHRSP platelets at hypertensive ages are due to an impaired function of thromboxane A2 and/or calcium concerned in aggregation and secretion but not due to a defect in cyclo - oxygenase and thromboxane synthetase pathway . - pubmed
Tumor foci were detected in frozen serial sections stained histochemically for estrase activity . - pubmed
The ability of these stilbene and steroidal estrogens to compete for renal tumor estrogen receptor generally correlated well with their ability to cause renal tumorigenesis in the hamster with one notable exception . - pubmed
Our results demonstrate that the cytochrome P450 isoenzymes responsible for the different pathways of antipyrine metabolism are affected to different extents by cirrhosis . - pubmed
The relative excess of alpha- over beta - globin chains in the erythroid precursors is the chief pathophysiological factor of homozygous beta - thalassemia . - pubmed
Differential expression of glial fibrillary acidic protein ( GFAP ) in the retinae and visual cortices of rats with experimental renal hypertension . - pubmed
To examine the expression of the GFAP protein in the retina and visual cortex under normal and pathological conditions , hypertension was induced in adult male Sprague - Dawley rats by applying silver clips onto renal arteries and the change in GFAP expression was followed by Western blotting and immunocytochemical staining . - pubmed
One week after operation when the induced hypertension was at the initial stage , GFAP expression in the retina was reduced to half of the sham control . - pubmed
By 4 weeks , when consistent hypertension was developed , a further decrease in the level of GFAP expression in the retina to one third of the sham control was observed . - pubmed
Immunocytochemical staining showed that the number of GFAP - positive cells in the nerve fiber layer of the retina of the hypertensive rat was reduced to less than one third of the sham control . - pubmed
However , similar changes in GFAP expression in the visual cortex of hypertensive rats were not observed . - pubmed
From June 1993 to July 1994 we treated 136 male patients affected by dysuria with hematic dosage of TPS and PSA , with DRE , transrectal echography and prostatic biopsy using an echograph . - pubmed
Pim-2 transgene induces lymphoid tumors , exhibiting potent synergy with c - myc . - pubmed
coli O157 isolates from cattle were verocytotoxigenic as determined by Vero cell assay and DNA hybridization , eaeA gene positive , contained a 92 kb plasmid and were thus typical of strains causing infections in man . - pubmed
In contrast isolates from pigs were non - toxigenic , eaeA gene negative and did not contain a 92 kb plasmid and would , therefore , be unlikely to be a source of infection for man . - pubmed
This review will provide the reader with a brief overview on some recent studies aimed at understanding the functional role of homeobox genes in normal mammalian development as well as their involvement in congenital malformations and oncogenesis . - pubmed
This assay also shows that depudecin induces an intricate network of actin stress fibers in these cells and in MG63 osteosarcoma cells and reveals the essential role of the epoxide and hydroxyl moieties in depudecin . - pubmed
Alterations in the expression of the breast and ovarian cancer susceptibility gene BRCA1 may contribute to the development of mammary and ovarian neoplasia . - pubmed
The sex - steroid estrogen modulates cell proliferation of normal and neoplastic breast and ovarian epithelial cells , but the role of estrogen regulation on the expression of BRCA1 remains to be defined . - pubmed
In this study , estrogen - regulated BRCA1 expression was examined in breast and ovarian cancer cells . - pubmed
Conversely , estrogen did not influence expression of BRCA1 in HBL-100 cells that lacked the estrogen receptor , although the constitutive levels of BRCA1 mRNA ( but not protein ) in these cells were 5- to 30 - fold higher than in other breast and ovarian cancer cells . - pubmed
We therefore propose that stimulation of cell proliferation may be a prerequisite for upregulation of BRCA1 in breast and ovarian cancer cells . - pubmed
SMARCC1 , SMARCC2 , and SMARCD1 are assigned to chromosomal regions that are frequently involved in somatic rearrangements in human cancers . - pubmed
SMARCD1 was mapped to the critical region of Allgrove syndrome ; however , no mutation was identified in one Allgrove syndrome family studied . - pubmed
QUALITY OF EVIDENCE : Randomized trials establish the efficacy of blood pressure control and angiotensin - converting enzyme ( ACE ) inhibition in slowing the progression of chronic renal disease . - pubmed
Partial correction of anemia with iron , erythropoietin , or androgens can improve quality of life and potentially prevent cardiac disease . - pubmed
Effects of long - term angiotensin II AT1 receptor blockade on survival , hemodynamics and cardiac remodeling in chronic heart failure in rats . - pubmed
OBJECTIVE : The beneficial effect of chronic angiotensin I converting enzyme ( ACE ) inhibition on survival has for long been established in the rat post - infarction model of chronic heart failure ( CHF ) and has subsequently been confirmed in humans . - pubmed
CONCLUSIONS : Long - term angiotensin II AT1 receptor blockade with irbesartan strongly and dose - dependently increases survival in the rat model of coronary ligation - induced CHF . - pubmed
Long - term AT1 receptor blockade might thus prove useful and prolong survival in human CHF . - pubmed
In patients with chronic liver injury , the elevation of serum ALT levels was mild for about 2 years , but persistent HGV infection existed . - pubmed
OBJECTIVE : To investigate the gene mutation of lipoprotein lipase(LPL ) of familial LPL deficiency in China . - pubmed
This is the first report about the gene mutation of LPL at this site in familial LPL deficiency . - pubmed
Human leucocyte antigen and insulin gene regions and nephropathy in type I diabetes . - pubmed
This study aimed to examine the role of human leucocyte antigen and insulin genes in susceptibility to nephropathy in patients with Type I diabetes . - pubmed
METHODS : We carried out a genetic association study examining insulin gene polymorphisms using three large cohorts of patients with Type I diabetes : nephropathy ( n = 258 ) , long duration non - nephropathy ( n = 153 ) and a recently diagnosed ( sporadic ) diabetic cohort ( n = 264 ) . - pubmed
RESULTS : No significant difference was seen in the distribution of human leucocyte antigen A , B , C , DR , DQA1 and DQB1 haplotypes and alleles between the three diabetic cohorts . - pubmed
No significant difference was seen in insulin ' + ' and ' - ' genotypes and alleles between the three diabetic cohorts . - pubmed
CONCLUSIONS / INTERPRETATION : Human leucocyte antigen and insulin gene loci are unlikely to have a major role in the susceptibility to nephropathy in Caucasian patients with Type I diabetes in the United Kingdom . - pubmed
Interleukin-10 inhibits hepatic injury and tumor necrosis factor - alpha and interferon - gamma mRNA expression induced by staphylococcal enterotoxin B or lipopolysaccharide in galactosamine - sensitized mice . - pubmed
BACKGROUND / AIMS : Proinflammatory cytokines including tumor necrosis factor alpha ( TNF - alpha ) and interferon gamma ( IFN - gamma ) play a critical role in the pathogenesis of liver injury induced by lipopolysaccharide ( LPS ) or staphylococcal enterotoxin B ( SEB ) in D - galactosamine ( GalN)-sensitized mice . - pubmed
The aim of this study was to examine the ability of interleukin-10 ( IL-10 ) , a recently characterized , highly potent anti - inflammatory mediator , to protect sensitized mice against hepatotoxicity induced by SEB or LPS . - pubmed
RESULTS : Treatment with IL-10 markedly reduced serum transaminase activities in a dose - dependent manner and reduced hemorrhagic liver damage in sensitized mice exposed to either toxin . - pubmed
CONCLUSIONS : These findings suggest that IL-10 is capable of regulating both T cell- and macrophage - mediated hepatic injury in vivo and that this cytokine might be useful in the treatment of acute liver failure . - pubmed
Sixty - one consecutive adult patients with leukaemia , primary myelofibrosis or myelodysplastic syndrome with an HLA - identical or one antigen mismatched family donor were randomised to allogeneic transplantation with PBPC or BM . - pubmed
Familial Alzheimer ' s disease presenilin-1 mutants potentiate cell cycle arrest . - pubmed
The NF2 tumor suppressor ( merlin / schwannomin ) has been cloned and extensively analyzed for mutations in patients with different clinical variants of the disease . - pubmed
Protective effect of Nocardia opaca lysozyme digest in experimental murine Candida albicans infections . - pubmed
BACKGROUND AND OBJECTIVES : We compared the outcome of bone marrow transplantation ( BMT ) from HLA - identical siblings ( MSD ) and one HLA - locus mismatched siblings ( PMSD ) in Chinese patients with hematologic malignancies in terms of transplant - related mortality ( TRM ) and disease relapse to see whether PMSD can feasibly increase the availability of donors in our population . - pubmed
Fourteen patients received BMT from HLA - A or -B PMSD : 11 of these patients died after a median of 5.6 months ( range 0.6 - 13.7 months ) due to severe GVHD ( n=5 ) , graft failure ( n=2 ) , bleeding ( n=1 ) , leukemic relapse ( n=2 ) and thrombotic thrombocytopenic purpura ( n=1 ) . - pubmed
INTERPRETATION AND CONCLUSIONS : BMT from PMSD ( especially those with mismatches at HLA class I loci ) carried a higher risk of TRM and morbidity than BMT from MSD in our population . - pubmed
Multiple endocrine neoplasia type 1 ( MEN1 ) gene was identified to be a tumor suppressor that encodes menin , playing an important role in the development of MEN1 - associated tumors . - pubmed
Somatic MEN1 gene mutations also were detected in sporadic non - MEN1 endocrine tumors . - pubmed
Ten of 18 tumors with 11q allelic loss successfully completed the sequence of the MEN1 gene coding region and splice junctions , and 3 of 10 ( 30 % ) tumors had no somatic mutation , indicating that other putative tumor - suppressor genes on 11q may contribute to their tumorigenesis . - pubmed
OBJECTIVE : To investigate clinical manifestations of relapsing polychondritis and to clarify the significance of type II collagen antibody in the disease . - pubmed
CONCLUSION : Though the measurement of type II collagen antibody titer is not a decisive factor for detection of relapsing polychondritis , it is useful as one of the complementary factors for the diagnosis , since there is no specific test for this disease . - pubmed
This paralysis of DC function could not be triggered in mice that were deficient in a key lipoxygenase involved in LXA ( 4 ) biosynthesis . - pubmed
Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production , expression of Bcl - XS and activation of caspase-3 . - pubmed
Serum osteoprotegerin levels in patients after liver transplantation and correlation to bone turnover , bone mineral density and fracture status . - pubmed
The aim of this cross sectional study was to evaluate the prevalence of osteoporosis , vertebral fracture status and possible risk factors of bone loss including serum osteoprotegerin , a novel key regulator of osteoclast proliferation and activity in the posttransplantation period . - pubmed
Two - thirds of the patients had elevated serum cross - laps , osteocalcin and bone specific alkaline phosphatase levels reflecting increased bone turnover . - pubmed
Serum osteoprotegerin ( OPG ) in liver transplant recipients was not significantly different when compared to healthy , matched controls ( 84.7 + /- 6.6 vs. 97.3 + /- 9.4 pg / ml , p = 0.50 ) and similar when fractured / non - fractured or osteoporotic / non - osteoporotic patients were compared . - pubmed
Serum OPG was not correlated to bone mass or fracture status in this cross sectional setting but was elevated together with other bone resorption and -formation markers . - pubmed
Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy - associated lipodystrophy . - pubmed
Adiponectin is a adipocytokine that is decreased in insulin resistant conditions . - pubmed
We determined serum adiponenctin and adiponectin mRNA concentrations in subcutaneous adipose tissue in HIV - positive HAART - treated patients with ( HAART+LD+ , n = 30 ) and without lipodystrophy ( HAART+LD- , n = 13 ) . - pubmed
Both serum adiponectin and mRNA concentrations correlated closely with features of insulin resistance , including liver fat content . - pubmed
[ Chloramphenicol - trypsin association in local treatment of chronic phlogosis of the sinal cavity and of the ear ] . - pubmed
Signaling danger : toll - like receptors and their potential roles in kidney disease . - pubmed
Tubular epithelial cells are among the non - immune cells that express TLR1 , - 2 , - 3 , - 4 , and - 6 , suggesting that these TLR might contribute to the activation of immune responses in tubulointerstitial injury ( e.g. - pubmed
In addition , TLR9 has been shown to be involved in antigen - induced immune complex glomerulonephritis and lupus nephritis by regulating humoral and cellular immune responses . - pubmed
It is likely that TLR are involved in many if not all types of renal inflammation . - pubmed
Here the authors provide an overview on the biology of TLR , summarize the present data on their expression in the kidney , and provide an outlook for the potential roles of TLR in kidney disease . - pubmed
Endogenous IL-13 limits humoral responses and injury in experimental glomerulonephritis but does not regulate Th1 cell - mediated crescentic glomerulonephritis . - pubmed
To test the hypothesis that , like the counterregulatory Th2 cytokines IL-4 and IL-10 , endogenous IL-13 limits effector Th1 responses in glomerulonephritis , crescentic glomerulonephritis was induced in IL-13+/+ and IL-13-/- mice . - pubmed
Although IL-13-/- mice developed increased serum antigen - specific antibody levels , increased glomerular antibody deposition and enhanced switching to the Th1 - associated IgG2a subclass , they developed a similar degree of crescentic glomerulonephritis , with similar glomerular T cell / macrophage numbers , renal impairment , and proteinuria . - pubmed
In immune complex ( apoferritin - induced ) glomerulonephritis , where renal injury is humorally mediated , IL-13-/- mice developed enhanced humoral immune responses and increased proteinuria , with increased IgG2a responses , a more peripheral distribution of immune complexes , but no alterations in leukocyte recruitment . - pubmed
These results demonstrate dissociation of IL-13 's effects in antigen induced renal disease with little effect on cellular responses but suppressive effects on humoral effectors and switching to IgG2a . - pubmed
They indicate a role for IL-13 in limiting antibody - mediated renal injury , but not in regulating DTH - like cell - mediated responses in the kidney . - pubmed
Improved understanding of the signalling pathways involved in insulin action and the impact of IGF-1 on these processes could lead to a better understanding of the pathophysiology of insulin resistance associated with obesity and type 2 diabetes and the identification of key molecules that could lead to newer and more effective therapeutic agents for treating these common disorders that are already an uprising epidemic of the 21st century . - pubmed
Pre- and posttreatment with elaterium and cucurbitacin B reduced CCl4 - hepatotoxicity , as shown reduction in the anormally increased sGPT levels . - pubmed
The tumor suppressor protein p53 mediates stress - induced growth arrest or apoptosis and plays a major role in safeguarding genome integrity . - pubmed
Mitral valve reconstruction in a compound heterozygote for sickle cell anemia and hemoglobin Lepore . - pubmed
B lymphocyte stimulator ( BLyS ) isoforms in systemic lupus erythematosus : disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels . - pubmed
Considerable evidence points to a role for B lymphocyte stimulator ( BLyS ) overproduction in murine and human systemic lupus erythematosus ( SLE ) . - pubmed
Nevertheless , the correlation between circulating levels of BLyS protein and disease activity in human SLE is modest at best . - pubmed
Accordingly , we assessed peripheral blood leukocyte levels of BLyS mRNA isoforms ( full - length BLyS and DeltaBLyS ) and plasma BLyS protein levels in patients with SLE , and correlated these levels with laboratory and clinical features . - pubmed
BLyS protein , full - length BLyS mRNA , and DeltaBLyS mRNA levels were greater in SLE patients ( n = 60 ) than in rheumatoid arthritis patients ( n = 60 ) or normal control individuals ( n = 30 ) . - pubmed
Although full - length BLyS and DeltaBLyS mRNA levels correlated significantly with BLyS protein levels in the SLE cohort , BLyS mRNA levels were more closely associated with serum immunoglobulin levels and SLE Disease Activity Index scores than were BLyS protein levels . - pubmed
Moreover , changes in SLE Disease Activity Index scores were more closely associated with changes in BLyS mRNA levels than with changes in BLyS protein levels among the 37 SLE patients from whom repeat blood samples were obtained . - pubmed
Thus , full - length BLyS and DeltaBLyS mRNA levels are elevated in SLE and are more closely associated with disease activity than are BLyS protein levels . - pubmed
BLyS mRNA levels may be a helpful biomarker in the clinical monitoring of SLE patients . - pubmed
CONCLUSION : TNF - alpha can induce the ceramide increase in GMC , which is significant to effect on the kidney injury of the rats with obstructive jaundice , by the means of inducing GMC apoptosis and decreasing the activity of PC - PLD . - pubmed
Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll - like receptor 4 , CD44 , and MD-2 . - pubmed
Cultured cells exposed to hyaluronan showed a pattern of gene induction that mimics the response seen in mouse skin after sterile injury with an increase in molecules such as transforming growth factor - beta2 and matrix metalloproteinase-13 . - pubmed
Explanation for the unique response to hyaluronan was provided by observations that a lack of TLR4 or CD44 in mice diminished the response to sterile injury , and together with MD-2 , was required for responsiveness to hyaluronan in vitro . - pubmed
CD34(+ ) cell recovery was higher with Sepax ( 86+/-11.6 % ) than with HES ( 81.5+/-12.5 % ) and TB ( 82.0+/-17.7 % ) ( P<0.008 and & lt;0.0001 , respectively ) and results with HES and TB were not significantly different ( P=0.7 ) . - pubmed
Synergistic antitumor effect of CXCL10 with hyperthermia . - pubmed
In the present study , we try to investigate whether the combination therapy of hyperthermia , a physical antiangiogenic modality , with CXCL10 would completely eradicate the established solid tumors . - pubmed
Mice were treated with either CXCL10 at 25 microg / kg once a day for 20 days , hyperthermia was given twice ( at 42 degrees C for 1 h , on day 6 and 12 after the initiation of CXCL10 ) , or together . - pubmed
RESULTS : The results showed that CXCL10 and hyperthermia inhibited the growth of Meth A fibrosarcoma and interestingly , the combination therapy enhanced the antiangiogenic effects and completely eradicated the established solid tumors . - pubmed
Histological examination revealed that CXCL10 + hyperthermia led to increased induction of apoptosis , tumor necrosis , and elevated lymphocyte infiltration compared with the controls . - pubmed
Effect of lipid - bound apoA - I cysteine mutants on lipopolysaccharide - induced endotoxemia in mice . - pubmed
Here , we reconstituted recombinant HDLs ( named rHDLwt , rHDL52 , rHDL74 , rHDL107 , rHDL129 , rHDL173 , rHDL195 , and rHDL228 ) by mixing wild type or those mutants with dipalmitoyl phosphatidylcholine and examined their in vivo effects on LPS - induced endotoxemia in mice . - pubmed
Administration of rHDL74 to mice injected with LPS also led to a decrease of plasma IL-6 , protection of lung against acute injury , and attenuation of endotoxin - induced clinical symptoms in mice , compared with controls injected with LPS only . - pubmed
However , injection of rHDL228 significantly increased plasma concentration of TNF - alpha and exacerbated LPS - induced lung injury . - pubmed
[ Wenyang Huoxue Recipe up - regulates the expression of angiopoietin-1 mRNA in rats with chronic aristolochic acid nephropathy ] . - pubmed
OBJECTIVE : To investigate the effects of Wenyang Huoxue Recipe ( WRHXR ) , a compound traditional Chinese herbal medicine for warming yang and promoting blood flow , on the expression of angiopoietin mRNA in rats with chronic aristolochic acid nephropathy induced by Caulis Aristolochia Manshuriensis ( CAM ) decoction , and to explore the protection mechanism of WYHXR against kidney damage . - pubmed
Renal pathology showed that renal damage in WYHXR - treated group was significantly reduced as compared with the CAM group . - pubmed
RESULTS : In OA cells , TGF - beta1 significantly reduced the percentage of hypo - diploid chondrocytes , as well as the percentage of internucleosomal DNA breakage . - pubmed
MKP-1 expression did not show significant modulation in OA or normal chondrocytes . - pubmed
However , PP2A activity was differentially modulated in normal and OA chondrocytes . - pubmed
In OA chondrocytes , PP2A activity was not altered by TGF - beta1 stimulation ; however in normal chondrocytes PP2A activity was significantly activated by TGF - beta1 . - pubmed
Caseinolytic protease : a protein vaccine which could elicit serotype - independent protection against invasive pneumococcal infection . - pubmed
In this study , we evaluated the protective efficacy of immunizing mice with caseinolytic protease ( ClpP ) protein antigen whose gene sequences were shown to be highly conserved in different strains of Streptococcus pneumoniae in an invasive - disease model ( intraperitoneal infection model ) , and protection against invasive challenge with 12 different serotypes of S. - pubmed
Our findings demonstrated that active immunization with ClpP and passive immunization with antibodies specific for ClpP could elicit serotype - independent protection effectively against invasive pneumococcal infection . - pubmed
Rac and Rho driving tumor invasion : who 's at the wheel ? - pubmed
Genome - wide analysis of regulators of Rho - family small GTPases has identified critical elements that control the morphology and invasive behavior of melanoma cells . - pubmed
Inhibition of mTOR in kidney cancer . - pubmed
The mammalian target of rapamycin ( mTOR ) has been shown to be an important target mechanism in the treatment of renal cell carcinoma ( RCC ) . - pubmed
There is now compelling clinical evidence for the effectiveness of targeting mTOR in the treatment of RCC . - pubmed
Corneal verticillata after dual anti - epidermal growth factor receptor and anti - vascular endothelial growth factor receptor 2 therapy ( vandetanib ) for anaplastic astrocytoma . - pubmed
RESULTS : A 48 - year - old female patient with a history of anaplastic astrocytoma status post resection , external beam radiation , and chemotherapy presented with glare symptoms , decreased contrast sensitivity , and increased lacrimation after approximately 12 months of therapy with the anti - epidermal growth factor receptor ( EGFR ) and anti - vascular endothelial growth factor receptor 2 protein tyrosine kinase inhibitor , vandetanib . - pubmed
CONCLUSIONS : Vandetanib ( ZD6474 ) , a protein tyrosine kinase inhibitor with dual anti - EGFR and anti - vascular endothelial growth factor receptor 2 action , may have contributed to the formation of corneal verticillata in our patient . - pubmed
Inhibition of EGFR , which is involved with corneal epithelial cell migration and wound healing , may play a role in the pathogenesis underlying corneal vortex keratopathy and ocular surface conditions with significant epithelial turnover . - pubmed
Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes . - pubmed
Tumors with 13q34 amplification were associated with high grade , estrogen receptor negativity , and expression of EGFR , CCNE , CK5 , and P - Cadherin , among other basal cell markers . - pubmed
Moreover , we have confirmed that tumors with 13q34 amplification significantly overexpress CUL4A and TFDP1 proteins . - pubmed
Tumors overexpressing either CUL4A or TFDP1 were associated with tumor proliferation and cell cycle progression markers . - pubmed
CONCLUSIONS : We conclude that 13q34 amplification may be of relevance in tumor progression of basal - like breast cancers by inducing overexpression of CUL4A and TFDP1 , which are both important in cell cycle regulation . - pubmed
A potential regulatory single nucleotide polymorphism in the promoter of the Klotho gene may be associated with essential hypertension in the Chinese Han population . - pubmed
BACKGROUND : Mice with defects in the Klotho gene exhibit multiple aging phenotypes including arteriosclerosis . - pubmed
We hypothesised that the G-395A polymorphism in the promoter region of the human Klotho gene may contribute to the prevalence of Essential Hypertension ( EH ) . - pubmed
METHODS : We investigate whether the G-395A polymorphism of Klotho is associated with EH in a population consisting of 215 patients with EH and 220 non - hypertensive subjects . - pubmed
CONCLUSIONS : The G-395A polymorphism of the human Klotho gene is associated with EH and may be a potential regulatory site . - pubmed
TRPV1 involvement in inflammatory tissue fibrosis in mice . - pubmed
We examined whether absence or blocking of transient receptor potential vanilloid subtype 1 ( TRPV1 ) affects the level of inflammation and fibrosis / scarring during healing of injured tissue using an alkali burn model of cornea in mice . - pubmed
A cornea burn was produced with 1 N NaOH instilled into one eye of TRPV1-/- ( KO ) ( n = 88 ) or TRPV1+/+ ( n = 94 ) mice . - pubmed
Examinations of the corneal surface and eye globe size suggested that the loss of TRPV1 suppressed inflammation and fibrosis / scarring after alkali burn , and this was confirmed by histology , IHC , and gene expression analysis . - pubmed
In conclusion , absence or blocking of TRPV1 suppressed inflammation and fibrosis / scarring during healing of alkali - burned mouse cornea . - pubmed
TRPV1 is a potential drug target for improving the outcome of inflammatory / fibrogenic wound healing . - pubmed
Long - term results of surgery plus fibrin sealant for anal fistula . - pubmed
AIM : The long - term recurrence rate of fibrin glue treatment was analysed in patients with trans - sphincteric cryptoglandular fistula operated by a two - phase procedure : ( i ) fistulectomy with seton placement ; ( ii ) fibrin sealant ( Tissucol Duo , Baxter ) insertion in the track . - pubmed
[ Study of resistance to chemotherapy mediated by ABC transporters in biopsies of glioblastoma multiforme ] . - pubmed
CONCLUSIONS : We propose that Mrp1 activity is responsible for the chemo - resistance of the glioblastoma multiforme and inhibition of this transporter could represent a plausible strategy for the treatment . - pubmed
The absence of OPN in vivo reduces dermal scarring . - pubmed
This suggests that OPN is involved in scar formation ; however , how OPN exerts these pro - scarring effects is unknown . - pubmed
CONCLUSION : OPN is associated with scar and exerts pro - scarring effects by increasing cellular migration , adhesion , proliferation , and contractility of human dermal fibroblasts . - pubmed
OPN may be useful for promoting closure of non - healing wounds and the OPN specific aptamer , R3 , may be useful for preventing fibrosis . - pubmed
Current approaches to the management of Her2 - negative metastatic breast cancer . - pubmed
Knowledge of the estrogen receptor ( ER ) , progesterone receptor ( PR ) , and Her2 receptor status of the metastatic tumor has become critical to determining the optimal treatment strategy in the metastatic setting as targeted therapeutic approaches are developed . - pubmed
So - called ' triple - negative ' breast cancer - lacking ER , PR , and Her2 overexpression - remains a major challenge . - pubmed
The role of foxp3 - expressing regulatory T cells and T helpers in immunopathogenesis of multidrug resistant pulmonary tuberculosis . - pubmed
It has been shown that the leading part in immune suppression at infiltrative , dissemination , and fibrosis - cavity pulmonary tuberculosis is played by natural regulatory CD4(+)CD25(+)Foxp3(+)-T lymphocytes . - pubmed
It has been demonstrated that in patients with fibrocavernous and infiltrative form of the disease and drug - resistant pulmonary tuberculosis the number of CD4(+)CD25(-)Foxp3(+)-regulatory T cells was increasing . - pubmed
tuberculosis , an increased number of CD3(+)CD4(+)CD25(- ) T helpers is determined by the pathogenic features of the development of the tuberculosis infection and is connected with the activation of Th1 - dependent immune response . - pubmed
Relevance of vascular peroxisome proliferator - activated receptor gamma coactivator-1alpha to molecular alterations in atherosclerosis . - pubmed
Expression of PGC-1alpha , SIRT1 , PPARgamma and adiponectin was reduced ( P<0.05 ) in aorta from atherosclerotic rabbits . - pubmed
The observed results suggest that PGC-1alpha could be considered to be a link between the main atherosclerotic processes ( endothelial dysfunction , oxidation and inflammation ) and alterations of other factors involved in vascular wall integrity , such as SIRT1 , PPARgamma and adiponectin . - pubmed
OBJECTIVES : Tacrine was the first acetylcholinesterase inhibitor approved for the treatment of Alzheimer disease . - pubmed
The significant delay in wound closure exhibited in diabetic wounds was mainly attributed to alterations in the granulation tissue formation and resolution , involving defects in wound bed maturation , vascularisation , inflammatory response and collagen deposition . - pubmed
In the new model , a cell - based wound therapy consisting of the application of plasma - derived fibrin dermal scaffolds containing fibroblasts consistently improved the healing response by triggering granulation tissue maturation and further providing a suitable matrix for migrating keratinocytes during wound re - epithelialisation . - pubmed
Serum gamma - glutamyltransferase activity and acute coronary syndromes . - pubmed
NKX2 - 1 / TTF-1 : an enigmatic oncogene that functions as a double - edged sword for cancer cell survival and progression . - pubmed
Emerging evidence indicates that NKX2 - 1 , a homeobox - containing transcription factor also known as TTF-1 , plays a role as a " lineage - survival " oncogene in lung adenocarcinomas . - pubmed
In T cell acute lymphoblastic leukemia , gene rearrangements lead to aberrant expression of NKX2 - 1 / TTF-1 . - pubmed
Despite accumulating evidence supporting its oncogenic role , it has become apparent that NKX2 - 1 / TTF-1 expression also has biological and clinical functions in the opposite direction that act against tumor progression . - pubmed
A road map to comprehensive androgen receptor axis targeting for castration - resistant prostate cancer . - pubmed
The persistent significance of the androgen receptor ( AR ) axis in CRPC was recently validated by the clinical efficacy of androgen synthesis inhibitors ( abiraterone ) and novel , second - generation AR antagonists ( enzalutamide ) . - pubmed
A treatment paradigm of comprehensive AR axis targeting at multiple levels ( androgen synthesis , metabolism , and action ) and at all relevant sites ( gonadal , adrenal , intratumoral ) simultaneously at the time of initiation of endocrine therapy ( instead of the current approach of sequentially adding one agent at a time and only after disease progression ) deserves examination in clinical trials to explore whether maximal first - line AR axis suppression via combination therapy can achieve maximal induction of cancer cell apoptosis ( before they have the chance to adapt and evolve into CRPC ) and thus , improve patient outcomes . - pubmed
Although IFN - gamma is required for resolution of Listeria monocytogenes infection , the identities of the IFN - gamma - responsive cells that initiate the process remain unclear . - pubmed
Itgax - cre(+)Ifngr1(f / f ) mice with selective IFN - gamma unresponsiveness in CD8alpha(+ ) dendritic cells displayed increased susceptibility to infection . - pubmed
We also found that Itgax - cre(+)Ifngr1(f / f ) mice survived infection with low - dose Listeria as the result of a second wave of IL-12 produced by Ly6C(hi ) monocytes . - pubmed
Diagnostic sensitivity was demonstrated by measuring significantly higher Ld from a human colon cancer cell line ( HT29 control vector ) than a less aggressive variant ( epidermal growth factor receptor knockdown ) . - pubmed
Rice fortified with iron given weekly increases hemoglobin levels and reduces anemia in infants : a community intervention trial . - pubmed
The objective of this study was to evaluate the impact of rice fortified with iron ( Ultrarice ) on hemoglobin and anemia prevalence compared with standard household rice . - pubmed
In this intervention , rice fortified with iron given weekly was effective in increasing hemoglobin levels and reducing anemia in infants . - pubmed
Anti - CCR4 monoclonal antibody mogamulizumab for the treatment of EBV - associated T- and NK - cell lymphoproliferative diseases . - pubmed
Furthermore , CCR4 was expressed on EBV - infected cells in 8 of 17 patients with EBV - associated T / NK - LPDs . - pubmed
Interestingly , CCR4 was positive in 5 of 5 patients with hydroa vacciniforme , a photodermatosis caused by the clonal expansion of EBV - infected gammadeltaT cells . - pubmed
could reduce the water content of the spinal cord , and suppress the expression of aquaporin-4 and glial fibrillary acidic protein after spinal cord injury . - pubmed
This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial fibrillary acidic protein . - pubmed
The expansion of the GGGGCC hexanucleotide repeat in the non - coding region of the Chromosome 9 open - reading frame 72 ( C9orf72 ) gene is the most common genetic cause of frontotemporal dementia ( FTD ) and amyotrophic lateral sclerosis ( ALS ) . - pubmed
Immunostaining of brain sections from patients with C9orf72 ALS showed that poly - GR was colocalized with a mRNA - binding protein , hnRNPA1 . - pubmed
Our results demonstrate that impaired protein translation mediated by poly - PR and poly - GR peptides plays a role in neurotoxicity and reveal that the pathways altered by the poly - dipeptides - mRNA complexes are potential therapeutic targets for treatment of C9orf72 FTD / ALS . - pubmed
AMPKalpha1 overexpression alleviates the hepatocyte model of nonalcoholic fatty liver disease via inactivating p38MAPK pathway . - pubmed
The results displayed that the AMPKalpha1 overexpression suppressed lipid accumulation in the cytoplasm , decreased triglyceride levels , maintained the survival of steatotic hepatocyte model with decreased cell apoptosis and increased survival rate . - pubmed
These results indicated that AMPKalpha1 may serve as a novel target for treatment of NAFLD . - pubmed
Prognostic evaluation of VEGFA genotypes and haplotypes in a cohort of Brazilian women with non metastatic breast cancer . - pubmed
Vascular Endothelial Growth Factor ( VEGF ) mediates angiogenesis , which is crucial for tumor development and progression . - pubmed
The present study aimed to evaluate the impact of VEGFA gene polymorphisms rs699947 , rs833061 , rs1570360 , rs2010963 and rs3025039 on breast cancer features and prognosis . - pubmed
VEGFA genotyping may add to prognostic evaluation of breast cancer , with rs699947 being the most likely to contribute . - pubmed
Serum and Plasma Levels of Vascular Endothelial Growth Factors in Relation to Quality of Glucose Control , Biomarkers of Inflammation , and Diabetic Nephropathy . - pubmed
Levels of vascular endothelial growth factors ( VEGF ) are regulated in a complex network of adipokines , glucose control , and low grade inflammation together with activated platelets , leucocytes , and endothelial dysfunction . - pubmed
Increased levels of VEGF are associated with enhanced angiogenesis and impaired repair mechanisms of vascular lesions in endorgans . - pubmed
Little is known about the interaction of systemic VEGF levels with quality of diabetes control , biomarkers of inflammation , and diabetic nephropathy . - pubmed
Moreover , it is unclear , whether serum and plasma VEGF levels are similarly suited to reflect risk associated with VEGF.In this case control study , we analyzed these parameters in serum and plasma of age and sex matched controls without diabetes ( n=99 ) and type 2 diabetes ( n=302 ) . - pubmed
Serum VEGF - A was significantly increased in patients with T2DM while plasma levels were in the same range as for controls . - pubmed
T2DM was associated with significantly higher levels of hsCRP , ALAT , and albumin / creatinine ratio . - pubmed
Correlation analysis revealed a significant relationship between VEGF - A , HbA1c , inflammation , and diabetic nephropathy . - pubmed
Our results indicate that increased VEGF - A levels in T2DM significantly depend on quality of HbA1c control . - pubmed
Collagenases and gelatinases regulate many physiological processes and are involved in the pathogenesis and progression of various disease states , such as osteoarthritis , renal fibrosis , and atherosclerosis . - pubmed
Biological significance of PinX1 telomerase inhibitor in esophageal carcinoma treatment . - pubmed
PinX1 can inhibit human telomerase activity and the expression of hTERT mRNA , reduce tumor cell growth and induce apoptosis . - pubmed
Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1 . - pubmed
RESULTS : We documented that lncRNA H19 ( H19 ) was increased in calcific aortic valve disease . - pubmed
CONCLUSIONS : These findings indicate that a dysregulation of DNA methylation in the promoter of H19 during calcific aortic valve disease is associated with a higher expression of this lncRNA , which promotes an osteogenic program by interfering with the expression of NOTCH1 . - pubmed
INTERVENTIONS : Both patients received brincidofovir for the treatment of cytomegalovirus infection with mutation of UL-97 . - pubmed
They presented an acute kidney injury without any occurrence of other clinical event such as introduction of nephrotoxic drug , graft rejection , urinary tract obstruction or infection , and calcineurin inhibitor overdosage . - pubmed
MATE2 Expression Is Associated with Cancer Cell Response to Metformin . - pubmed
PURPOSE : Here we sought to determine if there is an association between the effects of metformin on inhibiting oxygen consumption , proliferation and expression of OCTs and MATEs in a panel of 19 cancer cell lines . - pubmed
EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor . - pubmed
However , the detailed molecular mechanism(s ) underlying the post - transcriptional regulation of EglN2 and its potential role in Triple Negative Breast Cancer ( TNBC ) remains largely unclear . - pubmed
By using C3Tag transgenic mice and tumor - derived C3Tag cell line , here we report that EglN2 contributes to TNBC tumor progression and genetic knockout of EglN2 improves C3Tag mice survival from tumor progression . - pubmed
Mechanistically , we further show that FBW7 , an E3 ligase complex component that is frequently downregulated in TNBC , negatively regulates EglN2 protein stability . - pubmed
Together , our study reveals that EglN2 might act as an FBW7 ubiquitin ligase substrate contributing to TNBC . - pubmed
Vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus . - pubmed
Among these , the Vitamin D receptor ( VDR ) gene is a good candidate for T2DM susceptibility . - pubmed
The aim of this study was to investigate the association between VDR polymorphisms and T2DM among a representative sample of the Emirati population . - pubmed
In regards to T2DM - related metabolic complications , the AG and GG genotypes of rs731236 were significantly associated with higher total cholesterol ( p=0.011 ) and LDL - cholesterol ( p=0.009 ) levels in the patients with T2DM . - pubmed
The frequency of AAT and GGC haplotypes was also different between groups ( p=0.014 ; p=0.032 , respectively ) , implying that these haplotypes of the VDR gene are associated with the susceptibility to T2DM in the Emirati population . - pubmed
To conclude , an association between SNPs in the VDR gene ( except for rs731236 ) and T2DM per se was demonstrated . - pubmed
The rs731236 variant was shown to be associated with high cholesterol and LDL - cholesterol levels in T2DM patients , while rs1544410 was associated with lower BMI and lower LDL cholesterol levels . - pubmed
Our results imply that alleles and haploypes of the VDR gene are associated with the susceptibility to T2DM in the Emirati population . - pubmed
There were no differences in endothelialization , vascular injury , or inflammation between the new test stents and BMS , although the new stents showed higher fibrin deposition ( P = .0006 ) . - pubmed
Furthermore , this method could detect multiple TFs in human colon cancer DLD-1 cells and reflect the variation in their cellular levels after stimulation . - pubmed
OBJECTIVE : This study aims to detect the role of DNA methylation in norepinephrine transporter ( NET ) gene promoter region on the association between depression and hypertension . - pubmed
RESULTS : For each CpG site and the average value of nine CpG sites , there were no significant differences in DNA methylation of the NET gene promoter between healthy controls and patients with depression or hypertension . - pubmed
CONCLUSION : Our study indicates that DNA methylation levels of nine CpG sites in NET gene promoter region are not associated with depression and hypertension . - pubmed
Deficient Insulin - mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy . - pubmed
Deficient insulin signaling is a key event mediating diabetic glomerulopathy . - pubmed
Therefore , we tested a link between insulin deficiency and dysregulated activity of the equilibrative nucleoside transporters ( ENTs ) responsible for controlling extracellular levels of adenosine . - pubmed
In glomeruli of streptozotocin - induced diabetic rats , insulin deficiency leads to decreased activity of ENT2 and chronically increased extracellular levels of adenosine . - pubmed
Treatment of diabetic rats with adenosine deaminase attenuated both the glomerular loss of nephrin and proteinuria . - pubmed
In conclusion , we evidenced ENT2 as a target of insulin signaling and sensitive to dysregulation in diabetes , leading to chronically increased extracellular adenosine levels and thereby setting conditions conducive to kidney injury . - pubmed
The rs1024611 in the CCL2 gene and risk of gynecological cancer in Asians : a meta - analysis . - pubmed
BACKGROUND : The -2518A / G ( rs1024611 ) polymorphism of the CCL2 ( C - C motif chemokine ligand 2 ) , also known as MCP-1 ( monocyte chemotactic protein-1 ) gene , has been reported to be associated with increased gynecological cancer risk , but the results are conflicting . - pubmed
METHODS : In this analysis , 1089 cases and 1553 controls from six publications were used to investigate the association between CCL2 - 2518A / G ( rs1024611 ) polymorphism and the risk of gynecological cancer with a meta - analytic approach . - pubmed
Six articles focused on the association between CCL2 - 2518A / G ( rs1024611 ) polymorphism , and gynecological cancer risk was selected and data were extracted . - pubmed
RESULTS : The meta - analysis showed that CCL2 - 2518A / G ( rs1024611 ) polymorphism is associated with risk of gynecological cancer ( GG vs AG + AA , OR = 1.55 , 95%CI = 1.07 - 2.24 , P & lt ; 0.05 ; AA vs GG , OR = 0.59 95%CI = 0.38 - 0.92 , P & lt ; 0.05 ) . - pubmed
CONCLUSIONS : Our data demonstrated the CCL2 - 2518A / G ( rs1024611 ) polymorphism is significantly associated with risk of gynecological cancer , and the association differs by ethnicity . - pubmed
The efficacy of erlotinib treatment for advanced non - small cell lung cancer ( NSCLC ) is due to its action as an epidermal growth factor receptor tyrosine kinase inhibitor ( EGFR - TKI ) . - pubmed
Sixty Han Chinese advanced non - small cell lung cancer patients received erlotinib monotherapy and , for each participant , 76 candidate genes ( related to EGFR signaling , drug metabolism and drug transport pathways ) were sequenced and analyzed . - pubmed
Rs1064796 in CYP4F11 and rs10045685 in UGT3A1 were significantly associated with adverse drug reaction . - pubmed
Tumor necrosis factor - alpha -308G / A gene polymorphism and novel biomarker profiles in patients with Takayasu arteritis . - pubmed
Tumor necrosis factor - alpha ( TNF - alpha ) is a cytokine with pleomorphic actions and plays a pivotal role in inflammation ; the serum level of TNF - alpha is genetically determined . - pubmed
However , the literature lacks adequate information on the association of TNF - alpha polymorphisms with TA . - pubmed
Hence , the present study investigates the contribution of TNF - alpha polymorphism toward the complex etiology of TA . - pubmed
The genetic study ( available for 57 TA patients and 36 controls ) revealed that the TNF - alpha -308A allele was overrepresented in the TA patients ( 12 % vs 7 % ) . - pubmed
Two studies by Phallen and colleagues and Anagnostou and colleagues correlated sensitive measures of ctDNA with clinical responses to tyrosine kinase inhibitors ( TKI ) and immune checkpoint inhibitors , respectively , in patients with non - small cell lung cancer ( NSCLC ) . - pubmed
The mRNA expression levels of IL-1beta , IL-6 , IL-8 , IFNs , TNF - alpha , Mx , and OASL were significantly upregulated during the viral infection . - pubmed
Identification of personalized antihypertensive treatments is a key for better BP management Objective : This review aimed to elucidate aspects of rational drug design and other methods to develop better hypertension management Results : Among hypertension - related signaling mechanisms , the renin - angiotensin - aldosterone system is the leading genetic target for hypertension treatment . - pubmed
Autosomal recessive primary microcephaly 5 ( MCPH5 ) is caused by pathogenic variants in ASPM . - pubmed
Ten ( 8.6 % ) had a positive family history , despite a few studies on RB1 gene . - pubmed
Correlations Among Subcutaneous Immunoglobulin Dosage , Immunoglobulin G Serum Pre - infusional Levels and Body Mass Index in Primary Antibody Deficiency Patients : A Pooled Analysis from the SHIFT / IBIS Studies . - pubmed
BACKGROUND AND OBJECTIVE : In recent years , two Italian non - interventional studies evaluated subcutaneous immunoglobulin ( SCIG ) treatment in patients affected by primary antibody deficiency ( PAD ) . - pubmed
CONCLUSIONS : These findings support the concept that the cumulative monthly dose of SCIG and the dose of SCIG per kilogram of body weight affect IgG trough levels in PAD patients , irrespective of BMI . - pubmed
We have previously developed a 4 - 1BB / CD3 - zeta - costimulated CAR - T cells against CD19 ( CART19 ) for adult acute lymphoblastic leukemia ( ALL ) . - pubmed
However , CART19 had no obvious effects on either the mean body mass or the blood cell counts , and no cytokine release syndrome and graft versus host disease were observed . - pubmed
Our study shed light on evaluation and supervision strategies for CAR - T products for the treatment of hematological diseases or leukemia . - pubmed
The radiosynthesis , quality control , and preliminary biological evaluation of [ 64Cu ] NOTA - PA1 have broaden the application of radiolabeled octreotide for SSTRs imaging , which could act as a potential multisubtypes targeted radiotracer for imaging SSTRs - positive tumors . - pubmed
Cerebral Ischemia - Reperfusion Injury : Lysophosphatidic Acid Mediates Inflammation by Decreasing the Expression of Liver X Receptor . - pubmed
In this study , we evaluated the expression of the liver X receptor ( LXR ) and nuclear factor kappa B ( NFkappaB ) by Western blotting , quantified the levels of IL-1beta , IL-6 , TNF - alpha , and LPA by ELISA , and evaluated apoptosis and infarct by TUNEL ( terminal deoxynucleotidyl transferase ( TdT ) dUTP nick - end labeling ) and TTC ( triphenyltetrazolium chloride ) staining respectively in Sprague - Dawley ( SD ) rats after middle cerebral artery occlusion ( MCAO ) . - pubmed
The levels of LPA , an extracellular signaling molecule , increased after ischemia and caused neurological injury effect , decreased the expression level of LXR , and increased the expression level of inflammatory factors ( IL-1beta , IL-6 , and TNF - alpha ) via the NFkappaB signaling pathway . - pubmed
In conclusion , we speculate that the inhibition of LPA generation and administration of LXR agonist may be explored as potential cerebral infarction treatment strategies . - pubmed
Tcf4 has been linked to autism , schizophrenia , and Pitt - Hopkins Syndrome ( PTHS ) in humans , suggesting a role for Tcf4 in brain development and importantly cortical development . - pubmed
Deletion of Tcf4 results in mis - specification of the cortical neurons , malformation of the corpus callosum and anterior commissure , and hypoplasia of the hippocampus . - pubmed
Furthermore , many genes that are differentially expressed after Tcf4 ablation are linked to other neurodevelopmental disorders . - pubmed
Taken together , we show that correct brain development and neuronal differentiation are severely affected in Tcf4 mutants , phenocopying morphological brain defects detected in PTHS patients . - pubmed
In the children with LN , the plasma levels of miR-145 and miR-183 were negatively correlated with SLEDAI score , anti - dsDNA antibody , Scr , and BUN ( P<0.05 ) and were positively correlated with complement C3 , complement C4 , and Alb ( P<0.05 ) . - pubmed
Receptor for Advanced Glycation End Products is Involved in Platelet Hyperactivation and Arterial Thrombosis during Chronic Kidney Disease . - pubmed
In this study , we analyzed the impact of CKD on platelet function and arterial thrombosis , and the potential role of RAGE in this process . - pubmed
METHODS : Twelve weeks after induction of CKD in mice , platelet function and time to complete carotid artery occlusion were analyzed in four groups of animals ( sham - operated , CKD , apolipoprotein E [ Apoe]-/- , and Apoe-/-/Ager-/- mice ) . - pubmed
RESULTS : Analysis of platelet function from whole blood and platelet - rich plasma showed hyperactivation of platelets only in CKD Apoe-/- mice . - pubmed
In vivo , CKD significantly reduced carotid occlusion times of Apoe-/- mice ( 9.2 + - 1.1 vs. 11.1 + - 0.6 minutes for sham , p < 0.01 ) . - pubmed
In contrast , CKD had no effect on occlusion times in Apoe-/-/Ager-/- mice . - pubmed
Moreover , carotid occlusion in Apoe-/- CKD mice occurred significantly faster than in Apoe-/-/Ager-/- CKD mice ( p < 0.0001 ) . - pubmed
CONCLUSION : Our results show that CKD induces platelet hyperactivation , accelerates thrombus formation in a murine model of arterial thrombosis , and that RAGE deletion has a protective role . - pubmed
We propose that RAGE ligands binding to RAGE is involved in CKD - induced arterial thrombosis . - pubmed
ARNTL2 promotes pancreatic ductal adenocarcinoma progression through TGF / BETA pathway and is regulated by miR-26a-5p . - pubmed
Increasing evidence shows that aryl hydrocarbon receptor nuclear translocator like 2 ( ARNTL2 ) plays crucial roles in tumorigenesis of multiple tumors . - pubmed
However , the expression status and functions of ARNTL2 in PDAC remain elusive . - pubmed
Here we showed that ARNTL2 expression was markedly upregulated in PDAC tissues and cell lines . - pubmed
Knockdown of ARNTL2 could suppress motility and invasive ability of PDAC cells in vitro , as well as tumor development in vivo . - pubmed
In addition , microRNA-26a-5p ( miR-26a-5p ) was identified as the crucial specific arbitrator for ARNTL2 expression and the expression of miR-26a-5p was inversely correlated with ARNTL2 expression in PDAC tissues . - pubmed
Functionally , elevated expression of miR-26a-5p was found to inhibit the proliferation , migration , and invasion of PDAC cells in vitro , while ARNTL2 increased expression could partially abolish the suppressive effect of miR-26a-5p . - pubmed
Mechanism study indicated that elevated expression of miR-26a-5p suppressed TGF / BETA signaling pathway by targeting ARNTL2 in PDAC cells . - pubmed
In conclusion , our data suggested that ARNTL2 acted as an oncogene to regulate PDAC growth . - pubmed
MiR-26a-5p / ARNTL2 axis may be a novel therapeutic candidate target in PDAC treatment . - pubmed
Factors Associated with Hepatitis B Surface Antigen Kinetics and Responses in Pegylated Interferon Alpha-2a Monotherapy for Patients with Chronic Hepatitis B. Objective Pegylated - interferon monotherapy is the standard treatment for patients with chronic hepatitis B ; however , the factors associated with its therapeutic effects remain unclear . - pubmed
Conclusion These findings suggest that the baseline HBsAg level , HBsAg kinetics at 12 weeks of treatment , and ALT increase during treatment are important factors contributing to the HBsAg response in pegylated interferon alpha-2a monotherapy for patients with chronic hepatitis B. - pubmed
Ferritins purified from horse spleen and from rat liver , kidney , heart and hepatoma were analyzed by quantitative polyacrylamide gel electrophoresis . - pubmed
However , the estimated charges on rat liver , kidney and hepatoma monomers ( 30 - 38 net protons per molecule ) differed from that of spleen monomer ( 51 net protons per molecule ) while the larger rat heart ferritin also had a greater charge ( 83 net protons ) than the smaller ( 40 net protons ) . - pubmed
Expression of T - antigen on polyagglutinable erythrocytes and carcinoma cells : preparation of T - activated erythrocytes , anti - T lectin , anti - T absorbed human serum and purified anti - T antibody . - pubmed
The combined effect of radiotherapy and neuraminidase - treated tumor cells on 3 - methylcholanthrene - induced fibrosarcoma . - pubmed
Active immunotherapy with tumor cells treated in vitro with Vibrio cholerae neuraminidase ( VCN ) plus mitomycin C augments the antitumor effects of local x irradiation in the treatment of firmly established methylcholanthrene - induced fibrosarcoma , MC-43 , in syngeneic C3H / HeJ female mice . - pubmed
This study demonstrates that fenfluramine - induced hyperthermia and stimulation in the rabbit result from an indirect action upon serotonergic receptors . - pubmed
Splenectomy at this late stage led to rapid relief of symptoms , progressive increase of Hb and platelets to normal levels and to a quiescent phase of CLL for a considerable period . - pubmed
histolytica , which varied in virulence as determined by the development of liver abscesses in hamsters , showed the same antigenic patterns with the mAb and with polyclonal antibodies . - pubmed
The study of hormonal balance in the presence of pregnancy and labor in females with a history of infertility treated with parlodel failed to reveal any negative effect of elevated prolactin levels on the fetoplacental system . - pubmed
In a longitudinal study of a female patient with systemic lupus erythematosus , we determined numbers of T - lymphocytes and subpopulations ( OKT4 + - and OKT8 + -lymphocytes ) , B - lymphocytes , production of anti - double - stranded DNA antibody ( anti - ds - DNA - Ab ) , and we investigated the effects of corticosteroids and cyclophosphamide on these parameters and clinical disease activity . - pubmed
Relationship between oral glucose tolerance and insulin sensitivity in healthy man and type 1 diabetic patients . - pubmed
The relationship between insulin sensitivity and oral glucose tolerance was studied in 8 conventionally treated type 1 diabetic patients ( age 34 + /- 4 years , relative body weight ( RBW ) 113 + /- 5 % ) and in 11 healthy subjects ( age 35 + /- 3 years , RBW 114 + /- 2 % ) . - pubmed
The response to oral glucose in the diabetic patients was measured during maintenance of similar peripheral plasma free insulin levels as in the normal subjects during the oral glucose tolerance test ( OGTT ) . - pubmed
Thus , peripheral insulin sensitivity contributes to oral glucose tolerance both in healthy man , and even to a greater extent , in type 1 diabetic patients . - pubmed
Reduced monoamine oxidase activity in platelets : a possible genetic marker for vulnerability to schizophrenia . - pubmed
Monoamine oxidase activity in blood platelets was measured , with [ ( 14 ) C ] tryptamine as substrate , in 13 monozygotic twin pairs discordant for schizophrenia and in 23 normal volunteers . - pubmed
The monoamine oxidase activity of both schizophrenic and nonschizophrenic co - twins was significantly lower than it was for the normals , and it was highly correlated between twins . - pubmed
In addition , there was a significant inverse correlation between a measure of the degree of the schizophrenic disorder and the monoamine oxidase activity . - pubmed
These data suggest , but do not prove , that reduced platelet monoamine oxidase activity may provide a genetic marker for vulnerability to schizophrenia . - pubmed
There was no significant association of ABO , Ss , Rhesus , Kell and Duffy blood groups in vitiligo . - pubmed
Activation of renin in an anaplastic pulmonary adenocarcinoma . - pubmed
Biochemical characteristics of a renin - like enzyme secreted by a pulmonary adenocarcinoma have been studied . - pubmed
A large fraction of the renin in this tumour is inactive . - pubmed
In comparison with other prohormones produced in tumours the findings support strongly the proposition that renin passes through a proenzyme step in synthesis . - pubmed
The study in 15 patients with myocardial infarction of the content in the arterial blood and the blood of the coronary sinus of lactate , glucose , nonesterified fatty acids has shown the increase of utilization of these substances in 5 cases , appearance of lactate production and enhancement of glucose and insulin extraction in 4 , decrease of extraction of glucose , lactate , insulin in 4 patients . - pubmed
In the complicated cases of myocardial infarction it was established that the extraction of glucose , insulin decrease and in a number of cased production of lactate by the myocardium supervenes . - pubmed
Since the intracellular activity of glutamine synthetase is significantly decreased after the administration of APAP to hepatocytes in culture , it is likely that the arylation of this enzyme may be involved in the ensuing hepatotoxicity . - pubmed
Repression of angiotensin II and potentiation of bradykinin contribute to the synergistic effects of dual metalloprotease inhibition in heart failure . - pubmed
Neutral endopeptidase inhibition ( NEP - I ) and angiotensin converting enzyme inhibition ( ACE - I ) act synergistically to produce acute beneficial hemodynamic effects in models of heart failure . - pubmed
In this study , the potential roles of Ang II repression and bradykinin potentiation were evaluated in conscious cardiomyopathic hamsters with compensated heart failure . - pubmed
Hence , both Ang II repression and bradykinin potentiation are factors contributing to the synergistic hemodynamic effects of combined NEP - I and ACE - I in hamsters with heart failure.(ABSTRACT TRUNCATED AT 250 WORDS ) - pubmed
Discrepancy between biochemical and virological responses to interferon - alpha in chronic hepatitis C. - pubmed
Fluctuations in elastase of cervical mucus and clinical efficacy of cefodizime in obstetric and gynecologic infections . - pubmed
Clinical efficacy of cefodizime ( CDZM ) in obstetric and gynecologic infections and in their prevention , and fluctuations in cervical mucus elastase in gynecologic infections and during pregnancy were studied , and the following results were obtained : 1 . - pubmed
Patients with concomitant chorioamnionitis showed a significantly higher rate of elastase elevation than those without this complication ( 63.2 % vs. 25.9 % , P & lt ; 0.005 ) . - pubmed
Cervical mucus elastase in uterine and pelvic infections showed high values before administration of CDZM but tended to decline with the progress of cure ( 15/19 cases , 78.9 % ) . - pubmed
This defect in insulin response leads to a diabetic - like state . - pubmed
A protease activity which co - purified with affinity - purified fetal bovine serum acetylcholinesterase ( AChE ) has been shown to release the amyloid protein precursor ( APP ) of Alzheimer ' s disease from cell membranes . - pubmed
The collagen bundles did not adopt a whorled pattern , and the overlying epidermis showed mild acanthosis and elongation of the rete ridges . - pubmed
Our study shows that liposomal antisense ODNs targeting bcl-2 of human myeloma cells result in increased stability of ODNs with minimal toxicity . - pubmed
Inhibition of proliferation and CD25 down - regulation by retinoic acid in human adult T cell leukemia cells . - pubmed
Cytokines in acute and chronic inflammation . - pubmed
Inflammation is mediated by a variety of soluble factors , including a group of secreted polypeptides known as cytokines . - pubmed
Inflammatory cytokines can be divided into two groups : those involved in acute inflammation and those responsible for chronic inflammation . - pubmed
This review describes the role played in acute inflammation by IL-1 , TNF - alpha , IL-6 , IL-11 , IL-8 and other chemokines , G - CSF , and GM - CSF . - pubmed
It also describes the involvement of cytokines in chronic inflammation . - pubmed
Some cytokines , such as IL-1 , significantly contribute to both acute and chronic inflammation . - pubmed
Amplicons from peacock enteritis and equine infertility specimens were not typeable according to present omp1 allelic criteria for the chlamydial species . - pubmed
Allele typing of amplicons from swine with intestinal , urogenital , and respiratory infections demonstrated several unique omp1 allelic variants of Chlamydia trachomatis . - pubmed
Reversal of cardiac fibrosis in deoxycorticosterone acetate - salt hypertensive rats by inhibition of the renin - angiotensin system . - pubmed
This project has determined the expression and deposition of collagens and fibronectin and cardiac function in the deoxycorticosterone acetate ( DOCA)-salt hypertensive rat after inhibition of the renin - angiotensin system . - pubmed
Thus , inhibition of the renin - angiotensin system reverses cardiac fibrosis in DOCA - salt rats and returns some indices of myocardial function to normal . - pubmed
RESULTS : Insulin sensitivity of women with chronic hypertension and GDM was approximately twofold lower than those with GDM only ( 1.54+/-0.35 versus 4.15+/-0.31 , P & lt ; .001 ) and approximately fivefold lower than controls ( 1.54+/-0.35 versus 7.65+/-0.66 , P & lt ; .001 ) . - pubmed
Women with chronic hypertension and concomitant GDM had higher insulin levels in response to GTT than controls ( P & lt ; .001 repeated measures analysis of variance ) . - pubmed
Oncostatin M ( OSM ) , a member of the IL-6 superfamily of cytokines , is elevated in patients with rheumatoid arthritis and , in synergy with IL-1 , promotes cartilage degeneration by matrix metalloproteinases ( MMPs ) . - pubmed
Smaller central pools of cholesterol later in life may contribute to reduced low - density lipoprotein - cholesterol ( LDL - C ) concentrations in the plasma and thus reduce the risk of cardiovascular disease . - pubmed
Furthermore , a comparative expression analysis is presented with Unc5h3 , deleted in colorectal cancer and Netrin-1 . - pubmed
EXEGESIS : This case report is a 44 year old black woman who was first seen with a rheumatoid arthritis clinical presentation associated with the presence of rheumatoid factor . - pubmed
Development of gene therapy using prostate - specific membrane antigen promoter / enhancer with Cre Recombinase / LoxP system for prostate cancer cells under androgen ablation condition . - pubmed
To enhance the efficacy of suicide gene therapy for prostate cancer under androgen deprivation , we designed a promoter system that consists of the prostate - specific membrane antigen ( PSMA ) promoter / enhancer ( PEPM ) and Cre - loxP DNA recombination system . - pubmed
Alteration of the expression of Bcl-2 , Bcl - x , Bax , Fas , and Fas ligand in the involved skin of psoriasis vulgaris following topical anthralin therapy . - pubmed
In this study , we examined the immunohistochemical expression of apoptosis - regulated protein in the involved psoriatic skin following topical anthralin therapy . - pubmed
HIV-1 + patients with Kaposi sarcoma ( KS ) were matched for CD4 count and HIV-1 RNA viral load to HIV-1 + patients without Kaposi sarcoma ( and negative for Kaposisarcoma - associated herpesvirus ) . - pubmed
Despite the impaired functional capacity of dendritic cells ( DCs ) derived from patients with KS , DCs retain the ability to prime the adaptive arm of the immune system through the common HSP receptor , leading to phenotypic activation and stimulation of tetramer - positive CD8 + cytotoxic T cells . - pubmed
[ Acquired hemolytic anemia ; follow - up over a long period of a patient treated with ACTH and cortisone ] . - pubmed
Serum leptin concentration and advanced gastrointestinal cancers : a case controlled study . - pubmed
We aimed to evaluate the serum leptin concentration and the other factors which may be associated with weight loss in patients with advanced gastrointestinal cancer . - pubmed
The difference in serum leptin concentration between cancer and control group , the factor associated with its serum level and the relationship between serum leptin concentration and weight loss was evaluated . - pubmed
RESULTS : Serum leptin concentration of cancer group was significantly lower than controls ( p = 0.002 ) . - pubmed
Female subjects had significantly higher serum leptin concentration than male subjects in control group ( p = 0.01 ) , while not in cancer group ( p & gt ; 0.05 ) . - pubmed
Serum leptin concentration was significantly related with gender in controls ( p = 0.023 , beta = 0.479 ) , while no gender difference was observed in cancer group ( p & gt ; 0.05 ) . - pubmed
No relationship was found between serum leptin concentration and weight loss percentage in cancer group in linear regression analysis ( p & gt ; 0.05 ) . - pubmed
No significant difference was observed in serum leptin concentrations between colon and gastric cancer sub - groups ( p & gt ; 0.05 ) . - pubmed
CONCLUSION : Independently from the site of gastrointestinal tract , serum leptin concentration in advanced gastrointestinal cancer is lower than controls and it is not a determinant factor in weight loss . - pubmed
In contrast to healthy subjects , gender does not effect the serum leptin concentration in patients with advanced gastrointestinal cancer . - pubmed
Growth factor therapy for vocal fold scarring in a canine model . - pubmed
Hepatocyte growth factor ( HGF ) has strong antifibrotic activity and has proved to have therapeutic potential in restoration of scar tissues such as liver cirrhosis and lung fibrosis . - pubmed
Canine vocal folds were stripped unilaterally and treated with intracordal injection of saline solution ( sham group ) , HGF ( HGF group ) , or HGF with cultured autologous normal vocal fold fibroblasts ( Fb / HGF group ) 1 month after injury . - pubmed
However , the HGF group presented much better results than both the sham and Fb / HGF groups in terms of mucosal wave amplitude and incidence of vocal fold bowing , glottal incompetence , and phase asymmetry . - pubmed
From these data it is concluded that HGF has considerable potential in the treatment of vocal fold scarring . - pubmed
Capillary tube collapse is accompanied by collagen gel contraction , which is strongly related to the wound contraction that occurs during regression of granulation tissue in vivo . - pubmed
Comparison of erythema and induration as results of tuberculin tests . - pubmed
DESIGN : The distributions of diameters of erythema and induration were compared among three groups : 951 TB patients , 6139 first - grade and 6185 seventh - grade children , and 97 volunteer employees classified as atopic or non - atopic on the basis of skin tests and serum immunoglobulin E ( IgE ) concentrations . - pubmed
CONCLUSION : Both erythema and induration appear to be adequate indices of tuberculin sensitivity . - pubmed
The candidate tumor suppressor gene ZAC is involved in keratinocyte differentiation and its expression is lost in basal cell carcinomas . - pubmed
ZAC expression is lost or down - regulated in some breast , ovary , and pituitary tumors and in an in vitro model of ovary epithelial cell transformation . - pubmed
In the present study , we examined ZAC expression in normal skin and found a high expression level in basal keratinocytes and a lower , more heterogeneous , expression in the first suprabasal differentiating layers of epidermis . - pubmed
Interestingly , we found a dramatic loss of ZAC expression in basal cell carcinoma , a neoplasm characterized by a relatively undifferentiated morphology . - pubmed
In contrast , ZAC expression was maintained in squamous cell carcinomas that retain the squamous differentiated phenotype . - pubmed
In the PNS , we recently showed that Schwann cell - derived EPO acts as an endogenous neuroprotectant and that it is most effective in preventing distal axonal degeneration seen in models of peripheral neuropathy . - pubmed
Similarly , we showed that immunophilin ligands are also neuroprotective in the PNS and prevent axonal degeneration seen in models of peripheral neuropathies . - pubmed
Both EPO and non - immunosuppressive immunophilin ligands are in early clinical development for the treatment of acquired peripheral neuropathies . - pubmed
Is elevated plasma B - natriuretic peptide in amyloidosis simply a function of the presence of heart failure ? - pubmed
This study sought to determine plasma levels of B - natriuretic peptide ( BNP ) in patients with light - chain - associated amyloidosis and correlate them with the presence or absence of heart failure ( HF ) and the presence or absence of echocardiographic abnormalities . - pubmed
Patients with normal echocardiographic results had significantly lower BNP levels than those with echocardiographic features of cardiac amyloidosis , whereas BNP levels in the group with HF did not differ from those in patients with asymptomatic cardiac amyloidosis . - pubmed
This observation supports previous observations , suggesting that the elevation of BNP in cardiac amyloidosis may be due not only to elevated ventricular filling pressure but also to direct myocyte damage due to extracellular deposits of amyloid . - pubmed
HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma . - pubmed
However , strong T - cell response does not always coincide with tumor rejection , for which upregulated expression of immunoinhibitory molecules may be responsible . - pubmed
In this study , the treatment with heat shock protein 70 ( HSP70 ) vaccine induced an infiltration of T cells into the tumor site as well as the expression of IFN - gamma and IL-2 , and delayed lung metastases of tumor , but the tumor progression nonetheless occur finally . - pubmed
We demonstrated that B7 - H1 expressed by residual tumor cells was responsible for the resistance of tumor to the therapy with HSP70 vaccine . - pubmed
To complement these findings , we investigated the gene expression of tumor - infiltrating lymphocytes ( TILs ) by Real - time PCR analysis , which revealed that the expression of TH1 cytokines IFN - gamma and IL-2 by TIL in the mice treated with HSP70 vaccine in combination with sPD-1 was increased and the expression of negative regulatory molecules IL-10 , TGF - beta and foxp3 was decreased , demonstrating that multifunctional properties afforded by the combination therapy can effectively overcome tumor resistance and promote effective antitumor immunity . - pubmed
These findings suggest that the treatment with HSP70 vaccine followed by blockade of tumor - B7 - H1 with sPD-1 may provide a promising approach for tumor immunotherapy . - pubmed
Pseudohypoparathyroidism Type 1 and Pseudo - pseudohypoparathyroidism occur as a consequence of reduced erythrocyte membrane coupled with Gs alpha activity . - pubmed
Altered neuregulin 1 - erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia . - pubmed
Recent molecular genetics studies implicate neuregulin 1 ( NRG1 ) and its receptor erbB in the pathophysiology of schizophrenia . - pubmed
Here , using a new postmortem tissue - stimulation approach , we show a marked increase in NRG1 - induced activation of erbB4 in the prefrontal cortex in schizophrenia . - pubmed
Levels of NRG1 and erbB4 , however , did not differ between schizophrenia and control groups . - pubmed
Schizophrenia subjects showed substantial increases in erbB4 - PSD-95 interactions . - pubmed
NRG1 - induced suppression of NMDA receptor activation was more pronounced in schizophrenia subjects than in controls , consistent with enhanced NRG1 - erbB4 signaling seen in this illness . - pubmed
Therefore , these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia . - pubmed
Plasma leptin levels in patients with floppy eyelid syndrome . - pubmed
PURPOSE : To determine the range of plasma leptin levels in patients with floppy eyelid syndrome ( FES ) . - pubmed
Charts were reviewed for patient age , sex , plasma leptin level , body mass index ( BMI ) , presence or absence of obstructive sleep apnea ( OSA ) and diabetes mellitus , and any treatments for OSA . - pubmed
CONCLUSIONS : Patients with FES demonstrate elevated plasma leptin levels , which correlate with BMI . - pubmed
The latest anti - poxvirus drugs are kinase inhibitors , which were originally developed to treat cancer progression but in addition block egress of poxviruses from infected cells . - pubmed
Erythropoietin promotes survival of retinal ganglion cells in DBA/2J glaucoma mice . - pubmed
METHODS : The neuroprotective effects of EPO were studied in the DBA/2J mouse model of glaucoma . - pubmed
CONCLUSIONS : EPO promoted RGC survival in DBA/2J glaucomatous mice without affecting IOP . - pubmed
These results suggest that EPO may be a potential therapeutic neuroprotectant in glaucoma . - pubmed
In spite of the difference between the compounds in both half - life and engagement of serotonin receptors , they appear to have very similar effectiveness in reducing hot flushes . - pubmed
Increased angiotensinogen production in epicardial adipose tissue during cardiac surgery : possible role in a postoperative insulin resistance . - pubmed
Recently , local renin - angiotensin system of adipose tissue has been suggested as a possible contributor to the development of insulin resistance in patients with obesity . - pubmed
Cardiac surgery significantly increased both insulin and blood glucose levels suggesting the development of insulin resistance , while serum adiponectin levels did not change . - pubmed
Our study suggests that increased angiotensinogen production in epicardial adipose tissue may contribute to the development of postoperative insulin resistance . - pubmed
In cardiology practice , the standard method of evaluating patients with suspected ischemic myocardial injury is an assay that measures the release of troponin into the bloodstream . - pubmed
In hematologic oncology practice , troponin has been investigated extensively as a measure of myocardial injury after therapy with radiation and anthracyclines and after myeloablative therapies with stem cell replacement . - pubmed
The use of troponin to assess the value of cardioprotective agents ( used for prevention of chemotherapy - induced myocardial injury ) also is reviewed . - pubmed
Because a number of nonmalignant hematologic disorders such as hypereosinophilic syndrome , thrombotic thrombocytopenic purpura , and immunoglobulin light - chain amyloidosis can affect the heart , the use of the troponin in assessing these patients ' prognoses is also covered . - pubmed
Knockdown of cytosolic 5 '- nucleotidase II ( cN - II ) reveals that its activity is essential for survival in astrocytoma cells . - pubmed
Fluctuations of cN - II activity have been associated with the pathogenesis of neurological disorders . - pubmed
To address this issue , we used a vector based short hairpin RNA ( shRNA ) strategy to knockdown cN - II activity in human astrocytoma cells . - pubmed
Since cN - II is highly expressed in tumour cells , our finding offers a new possible therapeutical approach especially against primary brain tumours such as glioblastoma , and to ameliorate chemotherapy against leukemia . - pubmed
Effect of metformin on serum visfatin levels in patients with polycystic ovary syndrome . - pubmed
OBJECTIVE : To evaluate serum visfatin levels and to determine the effects of metformin treatment on visfatin levels in patients with polycystic ovary syndrome ( PCOS ) . - pubmed
INTERVENTION(S ): Metformin was given to patients with PCOS , and serum visfatin levels were measured before and after treatment . - pubmed
MAIN OUTCOME MEASURE(S ): Glucose , triglycerides , high - density lipoprotein cholesterol , low - density lipoprotein cholesterol , DHEAS , total T , insulin , homeostatic model assessment for insulin resistance ( HOMA - IR ) , and visfatin levels were measured . - pubmed
RESULT(S ): Serum visfatin levels were significantly higher in women with PCOS than in controls . - pubmed
After therapy , statistically significant decreases in HOMA - IR , fasting insulin , free T , and DHEAS concentrations were observed for the PCOS group . - pubmed
CONCLUSION(S ): Circulating visfatin levels were higher in patients with PCOS than healthy controls , and metformin treatment significantly reduced circulating visfatin concentrations after 3 months of therapy . - pubmed
Numerous studies have shown that the microtubule - associated protein tau ( Mapt ) gene plays an important role in tauopathies . - pubmed
Expression correlation and genetic network analysis demonstrated that Mapt co - varies with many tauopathies - related genes , including Gsk3b , Falz , Apbb2 , Slc1a3 , Ntrk2 , Pik3ca , and Ikbkap . - pubmed
The prevalence in human cancers of mutations in p53 exemplifies its crucial role as a tumor suppressor transcription factor . - pubmed
It has been proposed that the mildly enhanced VWF proteolysis associated with C1584 ( and also with blood group O ) may compromise clot formation , offering a further rationale for the enrichment of the variant in type 1 VWD . - pubmed
It reflects the interaction of C1584 with other variables , one of which is clearly blood group O. Genome - wide association studies aimed at identifying loci involved in the control of the VWF level may provide further insights into C1584 penetrance and , more generally , into mechanisms underlying type 1 VWD and also cardiovascular disease . - pubmed
GENETIC COUNSELING : The hereditary ataxias can be inherited in an autosomal dominant , autosomal recessive , or X - linked manner . - pubmed
Inactivation of presenilins causes pre - synaptic impairment prior to post - synaptic dysfunction . - pubmed
Presenilins 1 and 2 are the major causative genes of early - onset familial AD . - pubmed
We show that ectopic expression of snail in developing olfactory neurons leads to severe defects in neurons of the antennal large basiconics , supporting the model that the dominant olfactory phenotype in Scutoid is caused by misexpression of snail . - pubmed
The animals were analyzed for clinical manifestation of arthritis , hematology and clinical chemistry , immunological responses against CII and histopathological features of the arthritis . - pubmed
BACKGROUND : Immunological and genetic findings implicate Th17 effector cytokines in the pathogenesis of inflammatory bowel disease ( IBD ) . - pubmed
The present study assessed the mRNA expression levels of Th17 effector cytokines ( IL17A , IL17F , IL21 , IL22 and IL26 ) and genes involved in differentiation ( IL6 , IL1B , TGFB1 , IL23A and STAT3 ) and recruitment of Th17 cells ( CCR6 and CCL20 ) by quantitative real - time PCR analysis of colonic and ileal biopsies from 22 healthy control subjects , 26 patients with Crohn ' s disease ( CD ) and 12 patients with ulcerative colitis ( UC ) . - pubmed
Inflammation was quantified by measuring expression of the inflammatory mediators IL8 and TNF . - pubmed
G6PD - MutDB : a mutation and phenotype database of glucose-6 - phosphate ( G6PD ) deficiency . - pubmed
Glucose-6 - phosphate dehydrogenase ( G6PD ) deficiency is the most common hereditary enzymatic disorder of red blood cells in humans due to mutations in the G6PD gene . - pubmed
G6PD - MutDB is a disease - specific resource of G6PD deficiency , collecting and integrating G6PD mutations with biochemical and clinical phenotypes . - pubmed
G6PD - MutDB implements an approach , CNSHA predictor , to help identify a potential chronic non - spherocytic hemolytic anemia ( CNSHA ) phenotype of an unknown mutation . - pubmed
Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species - mediated mitochondrial dysfunction and MAPK activation . - pubmed
BACKGROUND AND AIMS : Allergic rhinitis ( AR ) and asthma share common mediators , cytokines , and chemokines from mast cells and basophils that are central to the complex cascade of events involved in the inflammatory response . - pubmed
MATERIAL AND METHODS : A comprehensive literature search was conducted for the following terms , alone or in combination : allergic rhinitis , asthma , antihistamines , histamine , and histamine receptors , and for the second - generation antihistamines azelastine , cetirizine , desloratadine , ebastine , fexofenadine , levocetirizine , loratadine , mizolastine , and rupatadine . - pubmed
alpha - Synuclein phosphorylation as a therapeutic target in Parkinson ' s disease . - pubmed
A prototypical protein that is hyperphosphorylated in the brain is alpha - synuclein ( alpha - syn ) - found in Lewy bodies and Lewy neurites - the pathological hallmarks of Parkinson ' s disease ( PD ) and other alpha - synucleinopathies . - pubmed
The genetic linkage of alpha - syn to PD as well as its pathological association in both genetic and sporadic cases have made it the primary protein of interest . - pubmed
We postulated that allergen - induced increase in FeNO could be related to heightened mucosal eosinophils and AHR to bradykinin in atopic asthma . - pubmed
In 10 atopic mild asthmatics , we found that the numbers of EG-2 + and CD4 + cells in bronchial submucosa were significantly increased after allergen compared to the respective counts after diluent ( p & amp;#x003C ; 0.01 ) . - pubmed
Gamma - glutamyl transferase : risk and prognosis of cancer . - pubmed
FK506 - binding protein 51 ( FKBP5 ) gene polymorphism is not associated with glucocorticoid therapy outcome in patients with idiopathic thrombocytopenic purpura . - pubmed
The FKBP5 gene single nucleotide polymorphisms ( SNP ) , rs1360780 , has been found to modulate GC sensitivity in stress - related psychiatric disorders . - pubmed
The polymorphism of FKBP5 , rs1360780 , was genotyped in 55 GC - resistant ITP patients , 157 GC - sensitive ITP patients and 110 unrelated healthy individuals using real - time PCR and cycling probe technology with DNA extracted from peripheral blood . - pubmed
No significant differences in FKBP5 rs1360780 genotypes ( P=0.51 ) and alleles ( P=0.89 ) were observed between the GC - resistant ITP patients and the healthy controls . - pubmed
The present study demonstrates that the FKBP5 polymorphism may not affect the response of ITP patients to GC treatment . - pubmed
Deletion of Flt1 from specialized glomerular pericytes , known as podocytes , causes reorganization of their cytoskeleton with massive proteinuria and kidney failure , characteristic features of nephrotic syndrome in humans . - pubmed
Antiplatelet therapy with aspirin and a platelet P2Y12 receptor antagonist reduces thrombotic and ischemic events after percutaneous coronary intervention and acute coronary syndrome . - pubmed
Radiosensitization of prostate cancer cells by the dual PI3K / mTOR inhibitor BEZ235 under normoxic and hypoxic conditions . - pubmed
Radioresistance may be due to tumor - hypoxia but also due to the PTEN mutation / deletion present in 70 % prostate cancers . - pubmed
We investigated whether the novel PI3K / mTOR inhibitor BEZ235 might sensitize prostate cancer cells to radiation and reduce hypoxia - induced radioresistance . - pubmed
MATERIALS AND METHODS : The potential radiosensitizing properties of BEZ235 were investigated in vitro and in vivo using two prostate cancer cell lines , PC3 ( PTEN(-/- ) ) and DU145 ( PTEN(+/+ ) ) , under normoxic ( 21 % O ( 2 ) ) and hypoxic ( 0.5 % O ( 2 ) ) conditions . - pubmed
RESULTS : BEZ235 rapidly inhibited PI3 K and mTOR signaling in a dose dependent manner and limited tumor cell proliferation and clonogenic survival in both cell lines independently of PTEN status . - pubmed
Moreover , BEZ235 inhibited PI3K / mTOR activation and radiosensitized both cell lines under normoxia and hypoxia . - pubmed
Serum carbohydrate antigen 125 is not an independent prognostic factor in patients with chronic lymphocytic leukemia . - pubmed
METHODS : We measured serum CA-125 concentration in 112 patients with chronic lymphocytic leukemia ( CLL ) and evaluated their association with Binet stage , serum lactate dehydrogenase ( LDH ) , beta2 - microglobulin ( beta2 - MG ) , CD38 , 70 - kDa zeta - associated protein ( ZAP-70 ) , immunoglobulin heavy - chain variable region ( IGHV ) mutated status and cytogenetic abnormalities . - pubmed
CD38 - positive ( p=0.020 ) and unmutated IGHV status ( p=0.034 ) were independent risk factors of worse OS . - pubmed
However , CA-125 is not an independent prognostic factor in patients with CLL . - pubmed
The IGF receptor ( IGF - R ) pathway represents a potential actionable target in SCLC patients . - pubmed
Indeed , the IGF - R pathway is involved in cancer development and progression and regulates different vital processes including fetal development , growth and metabolism . - pubmed
AREAS COVERED : This review provides an overview of insulin inhibitors and the strategies undertaken in recent years with SCLC . - pubmed
Furthermore , insulin inhibitors may have some utility in the treatment of SCLC and further studies are required to identify subsets of patients most likely to benefit from their use . - pubmed
The authors also believe that it is important to determine the exact role of the IGF pathway in the pathogenesis and propagation of SCLC . - pubmed
Therefore B2 may be a promising candidate for further clinical studies and the appropriate use of GAD agonist may be a promising approach for sleep disorders . - pubmed
Aim of the study was to investigate the role of peanut- and hazelnut - component - specific IgE in the diagnostics of peanut and hazelnut allergy and to identify cutoff levels to make some challenges superfluous . - pubmed
A 90 % probability for a positive peanut or hazelnut challenge was estimated for Ara h 2 - specific IgE at 14.4 kU / l and for Cor a 14 - specific IgE at 47.8 kU / l. A 95 % probability could only be estimated for Ara h 2 at 42.2 kU / l. CONCLUSIONS : Ara h 2- and Cor a 14 - specific IgE are useful to estimate the probability for a positive challenge outcome in the diagnostic work - up of peanut or hazelnut allergy making some food challenges superfluous . - pubmed
Multicentre randomised phase II trial of gemcitabine+platinum , with or without trastuzumab , in advanced or metastatic urothelial carcinoma overexpressing Her2 . - pubmed
AIM : To investigate the efficacy and safety of gemcitabine and platinum salt , with or without trastuzumab , in patients with locally advanced or metastatic urothelial carcinoma overexpressing Her2 . - pubmed
METHODS : The main eligibility criterion was Her2 overexpression on immunohistochemistry ( IHC 2 + or 3 + ) of primary tumour tissue confirmed by fluorescence in situ hybridisation ( FISH ) . - pubmed
Multiple compound - related adverse properties contribute to liver injury caused by endothelin receptor antagonists . - pubmed
Drug - induced liver injury has been observed in patients treated with the endothelin receptor antagonists sitaxentan and bosentan , but not following treatment with ambrisentan . - pubmed
Mutations in NADH dehydrogenase ( ND ) subunits of complex I lead to mitochondrial encephalomyopathies associated with various phenotypes . - pubmed
Reduction of CD8(+ ) T lymphocytes in multiple sclerosis patients treated with dimethyl fumarate . - pubmed
Patients with nephrotic syndrome typically present with peripheral oedema , massive urinary protein loss and associated low serum albumin levels . - pubmed
Taken together , our study indicates that miR-204 may contribute to the development of preeclampsia by inhibiting trophoblastic invasion , and that MMP9 is involved in miR-204 - mediated trophoblast cell invasion . - pubmed
Predictors of early discontinuation of basal insulin therapy in type 2 diabetes in primary care . - pubmed
AIMS : To identify patient - related characteristics and other impact factors predicting early discontinuation of basal insulin therapy in type 2 diabetes in primary care . - pubmed
In multivariable logistic regression , predictors of early basal insulin discontinuation were & gt;=1 documented hypoglycemia before ID ( adjusted Odds ratio ; 95 % CI : 2.20 ; 1.27 - 3.82 ) , diagnosed depression ( 1.31 ; 1.01 - 1.70 ) and referrals to specialists within 90 days after ID ( 2.06 ; 1.61 - 2.63 ) . - pubmed
CONCLUSIONS : Less than 10 % of type 2 diabetes patients switched back to oral antidiabetic drugs within 90 days after start of basal insulin therapy . - pubmed
In particular , patients with baseline depression and frequent or severe hypoglycemia have a higher likelihood for early discontinuation of basal insulin , whereas use of insulin glargine and diabetologist care are related to an increased chance of continuous insulin treatment . - pubmed
FOXP3 + T - regulatory ( Treg ) cells have important roles in immune homeostasis , and alterations in their number and function can predispose to diseases ranging from autoimmunity to allograft rejection and tumor growth . - pubmed
Cystatin C- and creatinine - based estimation of glomerular filtration rate ( eGFRcys and eGRFcreat , respectively ) and urinary albumin / creatinine ratio ( ACR ) were assessed to investigate their relationship with the risk of atrial fibrillation . - pubmed
Leuprolide acetate , a synthetic nonapeptide analogue of gonadotropin - releasing hormone ( GnRH or LHRH ) , is the active pharmaceutical ingredient used to treat a wide range of sex hormone - related disorders , including advanced prostatic cancer , endometriosis , and precocious puberty . - pubmed
This study aimed to explore the possibility of an association between lipoxin A4 and interleukin-12 in chronic periodontitis . - pubmed
CONCLUSIONS : The mean interleukin-12 concentration was significantly higher in gingival crevicular fluid from patients with periodontitis than in that from with healthy patients , and the mean lipoxin A4 concentration was lower in patients with periodontitis than in healthy patients . - pubmed
Tumors from patients with progressive disease showed a higher variance of the intrapatient mutational spectrum and a higher frequency of APOBEC - related mutations . - pubmed
However , neutrophil - predominant pleural TB was associated with significantly higher inflammatory serum markers , such as white blood cell count ( P = 0.001 ) and C - reactive protein ( P = 0.001 ) . - pubmed
The canonical NF - kappaB pathway has been implicated in the initiation of GC reaction , and defects in this pathway have been linked to immune deficiencies . - pubmed
Lastly , we show that ectopic expression of Bcl-2 can partially rescue the GC phenotype in MALT1 - deficient animals by prolonging the lifespan of BCR - activated B cells , but plasma cell differentiation and Ab production remain defective . - pubmed
Significance of dynamic changes in gastric smooth muscle cell apoptosis , PI3K - AKT - mTOR and AMPK - mTOR signaling in a rat model of diabetic gastroparesis . - pubmed
The aim of the present study was to investigate the significance of cell apoptosis , the phosphoinositide-3 - kinase ( PI3K)-protein kinase B ( AKT)-mammalian target of rapamycin ( mTOR ) pathway , and the 5 ' adenosine monophosphate - activated protein kinase ( AMPK)-mTOR pathways in the process of diabetic gastroparesis . - pubmed
The apoptosis of gastric smooth muscle cells gradually increased in all diabetic groups , and significant changes were observed in key proteins involved in PI3K - AKT - mTOR and AMPK - mTOR signaling . - pubmed
The results indicated that apoptosis was important in the occurrence of diabetic gastroparesis , and the PI3K - AKT - mTOR and AMPK - mTOR pathways were activated during the apoptotic processes , but were incapable of regulating apoptosis . - pubmed
METHODS : 448 RA and 648 healthy controls were genotyped for single - nucleotide polymorphisms ( SNPs ) in genes ZKSCAN5 ( rs11761528 ) , SULT2A1 ( rs2637125 ) , HHEX ( rs2497306 ) , and ARPC1A ( rs740160 ) . - pubmed
The cumulative number of alleles associated with lower DHEAS within genes ZKSCAN5 , SULT2A1 , HHEX , and ARPC1A present in each individual negatively correlated with DHEAS levels in RA patients , but not in controls . - pubmed
Linear regression analysis showed significant effect of polymorphisms in genes ZKSCAN5 and ARPC1A on serum DHEAS levels in female RA patients but not in the control group . - pubmed
Carbonic anhydrase I , betaine - homocysteine S - methyltransferase 1 , fumarate hydratase , isovaleryl - CoA dehydrogenase , short - chain specific acyl - CoA dehydrogenase and arginase-1 were all down - regulated in the tumors with portal vein thrombosis . - pubmed
CONCLUSION : Metabolic enzymes and cytosol carbonic anhydrases were downregulated in hepatocellular carcinoma with portal vein thrombus . - pubmed
The deficiency of metabolic enzymes and cytosol carbonic anhydrases may alter cellular metabolisms and acid - base balance in hepatocellular carcinoma , which may facilitate to invade portal vein . - pubmed
Rindopepimut with temozolomide for patients with newly diagnosed , EGFRvIII - expressing glioblastoma ( ACT IV ): a randomised , double - blind , international phase 3 trial . - pubmed
In the ACT IV study , we aimed to assess whether or not the addition of rindopepimut to standard chemotherapy is able to improve survival in patients with EGFRvIII - positive glioblastoma . - pubmed
Eligible patients had newly diagnosed glioblastoma confirmed to express EGFRvIII by central analysis , and had undergone maximal surgical resection and completion of standard chemoradiation without progression . - pubmed
Patients were stratified by European Organisation for Research and Treatment of Cancer recursive partitioning analysis class , MGMT promoter methylation , and geographical region , and randomly assigned ( 1:1 ) with a prespecified randomisation sequence ( block size of four ) to receive rindopepimut ( 500 mug admixed with 150 mug GM - CSF ) or control ( 100 mug keyhole limpet haemocyanin ) via monthly intradermal injection until progression or intolerance , concurrent with standard oral temozolomide ( 150 - 200 mg / m2 for 5 of 28 days ) for 6 - 12 cycles or longer . - pubmed
METHODS : A total of 157 HIV - infected patients were screened through standard serological tests , including Wright 's test , Coombs ' Wright test , and 2 - mercaptoethanol Brucella agglutination test ( 2ME test ) , blood cultures in Castaneda media , and CD4 counting . - pubmed
Moreover , patients with positive serology and a mean CD4 count of 355.8 + - 203.11 cells / muL had no clinical manifestations of brucellosis , and , and the other patients had a mean CD4 count of 335.55 + - 261.71 cells / muL. - pubmed
Recently , a number of reports have described dominant C3 deposits in renal biopsies of patients with infection - related glomerulonephritis ( GN ) . - pubmed
While acute post - infectious GN and membranoproliferative GN are commonly characterized by immune deposits containing C3 and/or C4 , the absence of immunoglobulin ( Ig ) and/or immune complexes at light or electron microscopy is a rather unusual observation . - pubmed
A more thorough understanding of the pathways that lead to complement assembly and deposition within the kidney is needed to support a new classification of complement - related lesions , including entities such as dense deposit disease , ( atypical ) hemolytic - uremic syndrome , dominant C1q , CFHR5 , C4d , and C3 glomerulopathies . - pubmed
We will briefly review recent work in this area , focusing on GN with selective complement C3 deposits . - pubmed
Studies in recent years have shown that electrical stimulation of the vagal efferent fibers can artificially modulate cytokine levels and reduce systematic inflammation . - pubmed
B - type natriuretic peptide is a useful biomarker for the estimation of volume overload in children with hypertension on peritoneal dialysis . - pubmed
AIM : The aim of the present study was to evaluate the usefulness of serum B - type natriuretic peptide ( BNP ) as a biomarker of fluid retention in hypertensive children on peritoneal dialysis ( PD ) . - pubmed
CONCLUSIONS : Serum B - type natriuretic peptide should be measured in hypertensive patients on PD to evaluate the volume status . - pubmed
KIF16B is a candidate gene for a novel autosomal - recessive intellectual disability syndrome . - pubmed
ALRN-6924 induced a complete remission in a patient with TP53 - wild - type angioimmunoblastic T - cell lymphoma , demonstrating the potential for rapid translation of discoveries from subtype - specific preclinical models . - pubmed
TGFA and miR-130b were also inversely expressed in osteosarcoma tissues . - pubmed
In addition , expression of TGFA was able to alter miR-130 - regulated osteosarcoma cell proliferation , migration and invasion . - pubmed
P - glycoprotein targeted photodynamic therapy of chemoresistant tumors using recombinant Fab fragment conjugates . - pubmed
P - glycoprotein ( Pgp ) has been considered as a major cause of cancer multidrug resistance ; however , clinical solutions to overcome this drug resistance do not exist despite the tremendous endeavors . - pubmed
In a mouse xenograft model of chemoresistant tumors , Fab conjugates showed Pgp specific delivery to chemoresistant tumors . - pubmed
Transforming growth factor - beta1 ( TGF - beta1 ) is one of very few cytokines produced in a latent form , requiring activation to exert any of its vastly diverse effects on development , immunity , and cancer . - pubmed
Copanlisib : An Intravenous Phosphatidylinositol 3 - Kinase ( PI3 K ) Inhibitor for the Treatment of Relapsed Follicular Lymphoma . - pubmed
Data Synthesis : Copanlisib is the first intravenous phosphatidylinositol 3 - kinase ( PI3 K ) inhibitor approved for the treatment of relapsed FL in patients who have received at least 2 prior systemic therapies . - pubmed
CASE PRESENTATION : The first patient was a 48 - year - old - Asian woman who presented with serum growth hormone 6.99 ng / ml and insulin - like growth factor 1 of 476 ng / ml , but no characteristic features of acromegaly . - pubmed
The second patient was a 40 - year - old - Asian woman who presented with serum growth hormone 31.14 ng / ml and insulin - like growth factor 1 of 709.6 ng / ml , but no characteristic features of acromegaly . - pubmed
The third patient was a 64 - year - old - Asian woman who presented with serum growth hormone 6.0 ng / ml and insulin - like growth factor 1 of 341 ng / ml , but no characteristic features of acromegaly . - pubmed
OBJECTIVES : Patients with Kawasaki disease can develop life - altering coronary arterial abnormalities , particularly in those resistant to intravenous immunoglobulin ( IVIg ) therapy . - pubmed
We tested the tumor necrosis factor alpha receptor antagonist etanercept for reducing both IVIg resistance and coronary artery ( CA ) disease progression . - pubmed
Mutations of SATB2 ( OMIM#608148 ) gene at 2q33.1 have been associated with the autosomal dominant SATB2 - associated syndrome ( SAS ) , which is still short of comprehensive diagnosis technologies for small deletions and low - level mosaicism . - pubmed
In this Chinese Han family , single nucleotide polymorphism array identified a 4.9 - kb deletion in the SATB2 gene in two consecutive siblings exhibiting obvious developmental delay and dental abnormalities but failed to find so in their parents . - pubmed
Angiotensin II ( ATII ) is a noncatecholamine vasopressor recently approved for the management of distributive shock , but limited data support its clinical utility . - pubmed
After logistic regression , it was observed that inadequacies of calcium ( OR : 4.11 ; 95 % CI : 2.33 - 6.66 ) , phosphorus ( OR : 3.03 ; 95 % CI : 1.98 - 5.79 ) , vitamin D ( OR : 5.01 ; 95 % CI : 2.92 - 6.71 ) and PTH ( OR : 5.45 ; 95 % CI : 4.49 - 6.74 ) were significantly higher in the MUHO group compared to the MHO Group . - pubmed
Hyperglycemia is a known complication of therapies used in the treatment of childhood cancer , particularly glucocorticoids and asparaginase . - pubmed
Like other types of DEB , EBP results from heterozygous or bi - allelic mutations in the gene COL7A1 encoding collagen VII which is the main component of the anchoring fibrils . - pubmed
CONCLUSION : In conclusion , this review summarizes recent progress in developing protease inhibitors for SARS - CoV-2 . - pubmed
Long - term tracking of tumor cell nestin expression in vivo revealed a stronger TM network integration and higher radioresistance of the nestin - high subpopulation . - pubmed
Glioblastoma cells that were both nestin - high and network - integrated were particularly able to adapt to radiotherapy with increased TM formation . - pubmed
Glucosyltransferase activity in kidney fractions of normal and streptozotocin - diabetic rats . - pubmed
Glucosyltransferase ( UDPglucose : galactosylhydroxylysine - basement membrane glucosyltransferase ) , an enzyme specifically involved in collagen synthesis , was measured in various kidney fractions of normal , diabetic and underfed rats , using as basis the incorporation of radioactivity into protein during incubation with UDP [ U-14C ] glucose and alkali - soluble fetal calf - skin collagen . - pubmed
Seven to 21 d after removing the inhibitor ( & gt ; or = 14 d after infection ) , the cells were trypsinized , passed to monolayers of human embryonic lung fibroblasts , and observed for VZV reactivation as indicated by typical cytopathic effects and the appearance of VZV antigens . - pubmed
Similar frequencies in patients and controls were observed for TaqI and BglII RFLPs of the TcR alpha constant segment ( C alpha ) , the latter earlier reported to be associated with MS . - pubmed
A previously reported MS - associated PssI RFLP of the V alpha 12 and C alpha gene segments could not be confirmed . - pubmed
The anti - HIV-1 activity of AS101 as reflected by inhibition of the different catalytic functions associated with viral RT , in the absence of drug - related toxicity to lymphocytes , together with its immunomodulating activity strongly argues in favor of its evaluation , as a therapeutic agent for patients with HIV infection . - pubmed
These results indicate that : 1 ) Protein deficiency provokes an impairment of IgA - B cell terminal differentiation . - pubmed
3 ) The increased number of OX8 + ( CD8 ) and OX22 + ( CD45R ) IEL might permit induction of intestinal delayed type hypersensitivity , thereby abrogating oral tolerance of systemic delayed type hypersensitivity . - pubmed
Patients with Krabbe disease and their family members were assayed for GALC activity in leukocytes or fibroblasts and were classified as affected , carrier , noncarrier , or unknown . - pubmed
The intensity of the TMAO resonance for CRF subjects was correlated with the plasma concentration of urea ( R = 0.55 ) and creatinine ( R = 0.74 ) , suggesting that the presence of TMAO is closely related to the degree of renal failure . - pubmed
p75c - myb expression in leukemia - lymphoma cells correlated with proliferation and differentiation . - pubmed
[ Serum cholinesterase activity in stomach carcinoma ] . - pubmed
The sensitivity of the assay was increased by using either a purer antibody preparation or the antiserum to the more potent immunogen ; the assay in which pure antibody to ST(C ) was used was 2,857 - fold more sensitive in detecting ST than the assay in which crude antiserum to ST ( S ) was used . - pubmed
The activities of 14 different aminopeptidases , 5 endopeptidases , 4 glycosidases , phosphatase , esterase , and ribonuclease ( RNase ) were measured in the muscle and bone of 12 normal controls and 12 dystrophic mice . - pubmed
Biological significance of aromatase activity in human breast tumors . - pubmed
Human breast carcinomas contain aromatase , the enzyme necessary for the conversion of androgens to estrogens . - pubmed
If present in sufficient amounts , aromatase could catalyze the synthesis of estrogens from plasma steroid precursors and produce high breast cancer tissue concentrations . - pubmed
To determine the biological importance of tumor aromatase , we validated a specific and highly sensitive 3H - labeled water release assay for aromatase and used this to quantitate the amount of estrogen synthesized in vitro in breast tumors . - pubmed
Of 61 human breast tumors studied , 48 contained measurable aromatase activity , ranging from 5 - 70.5 pmol estrone formed / g . - pubmed
Finally , the amount of aromatase activity present in most tumors was insufficient to produce biologically meaningful saturation of estrogen receptors . - pubmed
These observations suggested that aromatase , while present in the majority of breast cancer tissues , may only be biologically important in those few tumors with very high aromatase activity . - pubmed
Kinetic analysis of bovine factor VIII in the hemophilic dog . - pubmed
Bovine factor VIII , which did not contain platelet aggregating factor activity , was infused into hemophilic dogs . - pubmed
Plasma PRL levels fell in all patients who showed a reduction in tumor size ; in 2 other patients , PRL levels were only poorly suppressed , and tumor size remained unchanged . - pubmed
In the remaining patients , PRL levels were lowered without convincing evidence of tumor shrinkage . - pubmed
Localization of Cu / Zn and Mn superoxide dismutase in various thyroid disorders . - pubmed
The intracellular localization of Cu / Zn - and Mn - superoxide dismutase ( SOD ) , which catalyze the dismutation of superoxide radicals ( O2- ) to O2 and H2O2 , was studied in the thyroid tissue of various thyroid disorders by an immunohistochemical technique . - pubmed
Copper / zinc - SOD in thyroid tissues were identified by immunocytochemical staining in most cases of papillary carcinoma and in some cases of other thyroid disorders . - pubmed
Manganese - SOD stained strongly in papillary carcinoma and papillary - growing cells in the thyroid tissue of adenoma and Graves ' disease . - pubmed
The concentrations of Cu / Zn - and Mn - SOD in thyroid tumor tissues and hyperplastic follicular disorders were significantly higher than those in normal thyroid tissue when they were compared as a function of protein or deoxyribonucleic acid contents . - pubmed
The ratio of Mn - SOD to Cu / Zn - SOD was significantly higher only in papillary carcinoma , except for other thyroid disorders as compared with that in the normal thyroid . - pubmed
In conclusion , SOD seems to be related to cell proliferation and differentiation in the thyroid follicular cell because Cu / Zn - SOD changes its localization in tumor and hyperplastic follicular cells and because the Mn - SOD concentration is increased in papillary carcinoma or papillary - growing cells . - pubmed
Therefore CA 19 - 9 and Sialyl Le ( x ) are tumor - associated antigens in the whole colorectum , and Leb and Le ( y ) in the distal colon . - pubmed
Expression of CA 19 - 9 in primary tumor provided more prognostic information and risk of liver metastasis than other Lewis blood group antigens . - pubmed
Other forms of cerebral amyloid angiopathy are exceptional : hereditary cerebral hemorrhages with amyloidosis differ from each another in type of fibrillar protein ( cystatine - C , variant of B protein , transthyretine ) . - pubmed
Immunohistochemically , most of the RER - positive cancers were reactive for cytokeratin ( 22/23 , 96 % ) and CEA ( 17/23 , 74 % ) , and negative for NSE ( 2/23 , 9 % ) , chromogranin ( 3/23 , 13 % ) and synaptophysin ( 0/23 , 0 % ) . - pubmed
In comparison to 46 RER - negative tumors , RER - positive cancer had less frequent CEA expression ( 17/23 , 74 % vs. 44/46 , 96 % , p = 0.01 ) . - pubmed
Beta - adrenergic antagonists in the prevention of gastrointestinal rebleeding in patients with cirrhosis : a meta - analysis . - pubmed
Yet , as we report herein , the diverse gL glycoproteins of Epstein - Barr virus ( EBV ) and varicella - zoster virus ( VZV ) were functionally interchangeable , although membrane expression and maturation of gH were separate functions for these viruses . - pubmed
Low prevalence of factor V : Q506 in 41 patients with isolated pulmonary embolism . - pubmed
It has been demonstrated that the most common coagulation defect predisposing to venous thrombosis , resistance to activated protein C ( APC ) , is not associated with an increased risk for pulmonary embolism , but the evidence was based on a functional assay to diagnose APC resistance and no information about concomitant deep vein thrombosis was provided . - pubmed
The aim of our study was to evaluate the prevalence of factor V : Q506 , the gene mutation responsible for APC resistance , in patients with symptomatic non - fatal pulmonary embolism , whether or not associated with deep vein thrombosis . - pubmed
The overall prevalence of factor V : Q506 in 106 patients with pulmonary embolism was 12.3 % , lower than that found in 106 patients with deep vein thrombosis ( 22.6 % , OR 0.5 , 95 % CI 0.2 - 1.0 ) but significantly higher than that found in 212 healthy subjects taken as controls ( 2.8 % , OR 4.8 , 95 % CI 1.8 - 13.0 ) . - pubmed
In conclusion , the prevalence of factor V : Q506 is high in patients with pulmonary embolism associated with deep vein thrombosis , whereas in patients with isolated pulmonary embolism it is similar to that found in control subjects . - pubmed
Vitamin E succinate inhibits proliferation of BT-20 human breast cancer cells : increased binding of cyclin A negatively regulates E2F transactivation activity . - pubmed
Characterization of human IgG1 monoclonal antibody against gangliosides expressed on tumor cells . - pubmed
A human IgG1.k monoclonal antibody ( MAb ) designated GMA1 was developed by fusing pooled lymph node lymphocytes from cancer patients with the human lymphoblastoid cell line , SHFP-1 . - pubmed
The GMA1 MAb reacted with several melanoma and neuroblastoma cell lines . - pubmed
Arterial hypertrophy in response to hypertension includes increases in the connective tissue proteins elastin and collagen . - pubmed
Adrenal - cortex autoantibodies and autoantibodies to 21 - hydroxylase were found in 81 % of the patients with autoimmune Addison ' s disease . - pubmed
None of the patients with nonautoimmune Addison ' s disease had adrenal - cortex autoantibodies or autoantibodies to 21 - hydroxylase . - pubmed
Steroid - producing cells autoantibodies were found in 26 % of the patients with autoimmune Addison ' s disease , and autoantibodies to 17alpha - hydroxylase and/or P450 side chain cleavage enzyme in 36 % of the patients . - pubmed
Steroid - producing cells autoantibodies were found in 11/13 ( 85 % ) of patients with idiopathic premature ovarian failure associated with autoimmune Addison ' s disease , and autoantibodies to 17alpha - hydroxylase and/or P450 side chain cleavage were found 12/13 ( 92 % ) of patients ; the only case negative for all these three markers suffered from Turner ' s syndrome . - pubmed
Angiotensin II receptor antagonists and hypertension . - pubmed
The injections produced soft tissue lesions characterized by three distinct phases that overlapped or existed simultaneously in one animal : an initial acute inflammatory reaction characterized by an infiltration of lymphocytes , monocytes and macrophages , a second mesenchymal fibromatous phase characterized by the predominance of spindle - shaped , focally atypical fibroblast - like cells and collagen , and a third premalignant neovascularization phase characterized by dominant capillary proliferations . - pubmed
[ In situ localization of mRNA gelatinases in cerebral aneurysms ] . - pubmed
OBJECTIVE : To explore the role of gelatinases A and B and their tissue inhibitors , TIMP-1 and TIMP-2 , in the formation of cerebral aneurysm . - pubmed
RESULTS : The levels of gelatinase B mRNA were found very high in cerebral aneurysms , especially in the site of internal elastic lamella . - pubmed
Gelatinase A TIMP-1 and TIMP-2 mRNA were not found in both cerebral aneurysms and normal cerebral arteries . - pubmed
CONCLUSIONS : Differential patterns of expression can be seen in situ , and tissue gelatinase B mRNA levels are elevated in aneurysms , suggesting that gelatinase B maybe responsible for the destruction of internal elastic lamina or even all laminae of cerebral arteries , leading to cerebral aneurysms . - pubmed
Injury was assessed histologically , as well as with Northern blots , probing for the enterocyte differentiation markers intestinal alkaline phosphatase and lactase , as well as the gut - epithelial marker villin . - pubmed
Intestinal alkaline phosphatase and lactase were lost immediately after ischemia and returned with reperfusion , confirming that the differentiated cells are particularly sensitive to ischemic injury . - pubmed
Interferon - alpha-2b and ribavirin for retreatment of chronic hepatitis C. - pubmed
BACKGROUND / AIMS : Subjects with chronic hepatitis C who fail treatment with interferon - alpha are generally divided into two groups : " relapsers " who normalized serum aminotransferase activity and have undetectable viral RNA during treatment and " non - responders " who do not achieve these results . - pubmed
Our data suggest that an aromatase inhibitor may be an effective treatment for ESS . - pubmed
The deposition of extracellular beta - amyloid peptide ( A beta ) in the brain is a pathologic feature of Alzheimer ' s disease . - pubmed
Serum endostatin predicts tumor vascularity in hepatocellular carcinoma . - pubmed
To analyze the protective effects of the aminotetraline derivative ( + /-)-( R , S )- 5,6 - dihydroxy-2 - methylamino-1,2,3,4 - tetrahydro - naphthalene hydrochloride ( CHF-1024 ) , a compound endowed with DA2 - dopaminergic / alpha2 - adrenergic receptor agonistic activity , in myocardial ischemia / reperfusion damage . - pubmed
Cardiac mechanics changes were evaluated together with biochemical markers of cardiac ischemia in perfusate and tissue tumor necrosis factor - alpha ( TNF - alpha ) . - pubmed
This anti - ischemic effect of CHF-1024 was associated to a decrease in creatine kinase and lactate dehydrogenase , both released during heart reperfusion . - pubmed
These events were concomitant with maintenance of a higher production of 6 - keto - prostaglandin F1alpha The ability of CHF-1024 to improve postischemic ventricular dysfunction was correlated with a dose - dependent inhibition of the release of both norepinephrine ( NE ) , from sympathetic nerve endings , and TNF - alpha from cardiac tissue . - pubmed
Soluble intracellular adhesion molecules ( sICAM-1 , sVCAM-1 ) in peripheral blood of patients with thyroid cancer . - pubmed
The aim of this work was estimation of the concentration of soluble intercellular adhesion molecules ( sICAM-1 ) and vascular cellular adhesion molecules ( sVCAM-1 ) in the serum of peripheral blood of patients with thyroid cancer before operation . - pubmed
We found statistically significant increase of sICAM-1 concentration in serum in all forms of cancer , in comparison with the control group . - pubmed
Mean concentrations of sICAM-1 were as follows : in papillary cancer patients 455.23+/-28.66 vs. 299.62+/-11.54 ng / ml , p<0.05 ; in oxyphilic cancer 455.60+/-95.21 vs. 299.62+/-11.54 ng / ml , p<0.05 ; in anaplastic cancer 570.00+/-170.89 vs. 299.62+/-11.54 ng / ml , p<0.05 ; and in medullary cancer 512.00+/-11.46 vs. 299.62+/-11.54 ng / ml , p<0.05 . - pubmed
The mean concentration of sVCAM-1 in serum was statistically significantly higher than in the control group only in case of anaplastic cancer ( 1033.75+/-86.30 vs. 644.58+/-27.30 ng / ml ; p<0.05 ) . - pubmed
We evaluated the correlation coefficient between the concentration of sICAM-1 and sVCAM-1 in the serum of patients with thyroid cancer . - pubmed
Hemolytic uremic syndrome ( HUS ) is associated with acute renal failure in children and can be caused by Shiga toxin ( Stx)-producing Escherichia coli . - pubmed
The ability of Stx to interact with previously activated platelets may be an important element in understanding the pathogenesis of HUS . - pubmed
Apoptosis in prostate carcinoma before and after neoadjuvant therapy with LH - RH analog . - pubmed
This study investigated apoptosis in prostate cancer before and after neoadjuvant treatment with LH - RH analog , demonstrating that this therapy induced high AI and bax and survivin overexpression , thus acting as a proapoptotic agent in prostate cancer . - pubmed
Highly active antiretroviral therapy ( HAART ) can dramatically decrease human immunodeficiency virus ( HIV ) load in plasma , increase CD4 + cell counts , and prolong life for HIV - seropositive persons . - pubmed
Suppression of Peutz - Jeghers polyposis by inhibition of cyclooxygenase-2 . - pubmed
Polyps in PJS patients and in Lkb1(+/- ) mice that model PJS polyposis are frequently characterized by elevated cyclooxygenase-2 ( COX-2 ) . - pubmed
This study was designed to determine whether COX-2 inhibition would reduce tumor burden in Lkb1 (+/- ) mice or Peutz - Jeghers patients . - pubmed
METHODS : Genetic interactions between Cox-2 and Lkb1 in polyp formation were analyzed in mice with combined deficiencies in these genes . - pubmed
In PJS patients , COX-2 was inhibited with a daily dose of 2 x 200 mg celecoxib for 6 months . - pubmed
RESULTS : Total polyp burden in Lkb1(+/- ) mice was significantly reduced in a Cox-2(+/- ) ( 53 % ) and in a Cox-2(-/- ) ( 54 % ) background . - pubmed
CONCLUSIONS : These data establish a role for COX-2 in promoting Peutz - Jeghers polyposis and suggest that COX-2 chemoprevention may prove beneficial in the treatment of PJS . - pubmed
Screening for mutations in six genes mapping to 7q , CUTL1 , SRPK2 , SYPL , LAMB1 , NRCAM and PTPRZ1 in 48 unrelated individuals with autism led to the identification of several new coding variants in the genes CUTL1 , LAMB1 and PTPRZ1 . - pubmed
Analysis of genetic variants provided evidence for association with autism for one of the new missense changes identified in LAMB1 ; this effect was stronger in a subgroup of affected male sibling pair families , implying a possible specific sex - related effect for this variant . - pubmed
Association was also detected for several polymorphisms in the promoter and untranslated region of NRCAM , suggesting that alterations in expression of this gene may be linked to autism susceptibility . - pubmed
The combination of elevated serum levels of free thyroid hormones with non - suppressed thyroid - stimulating hormone suggests the differential diagnoses of resistance to thyroid hormone or thyroid - stimulating hormone - secreting pituitary tumour . - pubmed
A case report of hidroacanthoma simplex with an immunohistochemical study of cytokeratins . - pubmed
In the group II levels of BALP and DPD were assessed twice : before treatment of hyperthyroidism and after 6 months since euthyroid state had been achieved . - pubmed
Improvement of the therapeutic index of adenoviral gene transfer requires the development of strategies to abrogate adenoviral capsid - induced inflammation and cytokine production . - pubmed
The effect of monomethoxypolyethylene glycol ( MPEG ) conjugation to adenoviral vectors and of methylprednisolone ( MP ) on innate immunity , liver inflammation , and thrombocyte counts was evaluated after transfer of 1011 particles of E1 / E3 / E4- deleted adenoviral vector expressing human apolipoprotein A - I ( apoA - I ) . - pubmed
This upregulation would potentially allow a similar twofold increase in the transport of other MCAs , including lactate , during insulin - induced hypoglycemia . - pubmed
Beta2 - adrenergic receptor genetic variants and risk of sudden cardiac death . - pubmed
BACKGROUND : Sympathetic activation influences the risk of ventricular arrhythmias and sudden cardiac death ( SCD ) , mediated in part by the beta2 - adrenergic receptor ( B2AR ) . - pubmed
We investigated whether variation in the B2AR gene is associated with SCD risk . - pubmed
METHODS AND RESULTS : In this study , 4441 white and 808 black Cardiovascular Health Study ( CHS ) participants were followed up prospectively for SCD and genotyped for B2AR Gly16Arg and Gln27Glu polymorphisms . - pubmed
Our findings suggest that B2AR plays a role in SCD in humans . - pubmed
Study of genetic variation within the B2AR gene may help identify those at increased SCD risk . - pubmed
Deer and elk with CWD have extensive aggregates of PrP(Sc ) not only in the central nervous system , but also in peripheral lymphoid tissues , skeletal muscle , and other organs , perhaps influencing prion shedding . - pubmed
Genetic polymorphisms in the Prnp gene may affect CWD susceptibility , particularly at codon 225 ( S / F ) in deer and codon 132 ( M / L ) in elk . - pubmed
Gene therapy with CX3CL1 / Fractalkine induces antitumor immunity to regress effectively mouse hepatocellular carcinoma . - pubmed
CX3CL1 / Fractalkine(FK ) , a chemokine existing in both secreted and membrane anchored form , was reported to induce suppressive activities in tumor models . - pubmed
Immunohistochemistry examination and fluorescence - activated cell sorting analyses revealed both CD4 + and CD8 + T cells infiltration within the tumor together with a marked increase of these cells in the peripheral blood . - pubmed
We also observed an increased production of IL-2 and IFN - gamma in MM45T.Li - FK tumor tissue . - pubmed
FK should be considered as a chemokine suitable for cancer immunoprevention or gene therapy . - pubmed
Differential regulation of systemic and intrarenal ( urinary ) ANG systems occurs during blockade , and suppression of the intrarenal system may contribute to reduced proteinuria . - pubmed
Thus , insulin resistance , renal injury , and activation of the intrarenal ANG system during early aging in normotensive animals can be averted by renin - ANG system blockade . - pubmed
However , oral cavity erosions appeared in December 2004 , and the titer of anti - Dsg3 autoantibodies in serum elevated , suggesting a transition from PF to pemphigus vulgaris ( PV ) . - pubmed
Perhaps the strongest finding in psychiatric genetics to date is the impressive effect that a single genetic variant , in the aldehyde dehydrogenase 2 gene , has on drinking behaviour and reducing the risk of developing alcohol dependence . - pubmed
Using infectivity assays , we found that the longer isoform of ZAP that contains the PARP - like domain is a stronger suppressor of murine leukemia virus expression and Semliki forest virus infection . - pubmed
LIGHT induces cell proliferation and inflammatory responses of rheumatoid arthritis synovial fibroblasts via lymphotoxin beta receptor . - pubmed
OBJECTIVE : To investigate the effects of LIGHT ( lymphotoxin - like , exhibits inducible expression and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator , a receptor expressed by T lymphocytes ) on the proliferation and gene expression of fibroblast - like synoviocytes ( FLS ) from patients with rheumatoid arthritis ( RA ) . - pubmed
METHODS : We measured LIGHT levels in RA synovial fluids ( SF ) by ELISA , and compared them with those in osteoarthritis ( OA ) SF . - pubmed
RESULTS : LIGHT was upregulated in both SF and synovium of RA patients compared with OA patients . - pubmed
CONCLUSION : Our findings suggest that LIGHT signaling via LTbetaR plays an important role in the pathogenesis of RA by affecting key processes such as the proliferation and activation of RA - FLS . - pubmed
Regulation of LIGHT - LTbetaR signaling may represent a new therapeutic target for RA treatment . - pubmed
OBJECTIVE : To determine plasma interleukin 6 ( pIL-6 ) , plasma vascular endothelial growth factor ( pVEGF ) , and serum ( s ) YKL-40 in patients with early rheumatoid arthritis ( RA ) and unclassified polyarthritis ( PA ) , and investigate their relationship with radiographic outcome . - pubmed
METHODS : pIL-6 and pVEGF were determined by ELISA and sYKL-40 by an in - house radioimmunoassay in 51 patients with early RA and 21 with PA . - pubmed
RESULTS : Baseline pIL-6 , pVEGF , sYKL-40 , C - reactive protein ( CRP ) , and erythrocyte sedimentation rate ( ESR ) were elevated in RA patients compared to healthy persons ( p & lt ; 0.001 ) , but were not in patients with PA . - pubmed
Patients with early RA had higher pIL-6 ( p = 0.007 ) , pVEGF ( p = 0.02 ) , and sYKL-40 ( p = 0.024 ) compared to PA patients . - pubmed
The mean value of pIL-6 during the first and second year were higher in patients with early RA with progression in bone erosions ( n = 14 ) compared to early RA patients without progression ( n = 30 ; first year 8.4 vs 2.8 ng / l , p = 0.04 ; second year 6.1 vs 3.6 ng / l , p = 0.03 ) . - pubmed
CONCLUSION : Plasma IL-6 was the only biomarker related to treatment response and progressive erosive disease in patients with early RA , but it may not give additional information compared to CRP in relation to disease activity and treatment response . - pubmed
BACKGROUND : Homeodomain - interacting protein kinase-2 ( HIPK2 ) plays an essential role in restraining tumor progression as it may regulate , by itself or within multiprotein complexes , many proteins ( mainly transcription factors ) involved in cell growth and apoptosis . - pubmed
RESULTS : HIPK2 overexpression in tumor cells downregulated VEGF mRNA levels and VEGF promoter activity . - pubmed
These findings support the function of HIPK2 as tumor suppressor and hypothesise a role for HIPK2 as antiangiogenic tool in tumor therapy approaches . - pubmed
Evaluation of the titin - cap gene ( TCAP ) as candidate for dilated cardiomyopathy in Irish wolfhounds . - pubmed
We analyzed the titin - cap ( TCAP , telethonin ) gene as candidate for DCM . - pubmed
We conclude that TCAP can most likely be eliminated as cause for DCM in IWs . - pubmed
It has been reported that oral premedication with the H ( 2 ) receptor antagonist famotidine augmented intraoperative hypothermia . - pubmed
Structural polymorphisms in the mannose - binding lectin gene are associated with juvenile idiopathic arthritis . - pubmed
OBJECTIVE : To investigate the possible association between polymorphisms of the mannose - binding lectin gene ( MBL2 ) and susceptibility to juvenile idiopathic arthritis ( JIA ) . - pubmed
RESULTS : Variant allele frequencies of both codon 52 and 57 polymorphisms in the MBL2 gene were significantly overrepresented in JIA ( p=0.001 and p=0.004 , respectively ) . - pubmed
The frequency of low MBL genotypes ( XA / XA , YA / YO , XA / YO , and YO / YO ) in JIA was higher than that in healthy controls ( p=0.001 ) . - pubmed
Serum MBL concentrations were found to be significantly lower in JIA patients versus control subjects ( p=0.001 ) . - pubmed
The 2 promoter polymorphisms and codon 54 SNP of the MBL2 gene were not associated with JIA . - pubmed
CONCLUSION : Our findings suggest that genetically determined low MBL levels may predispose children to JIA in a Hungarian population . - pubmed
In Digestive Disease Week 2008 , interesting advances in the treatment of hepatitis C were presented , especially related to the promising increase in the therapeutic efficacy of the combination of conventional treatment with the protease inhibitor , telaprevir . - pubmed
Corticosteroids reduce glial fibrillary acidic protein expression in response to spinal cord injury in a fetal rat model of dysraphism . - pubmed
Corticosteroids modulate GFAP synthesis , but their effect in MM is unclear . - pubmed
The purpose of this study was to evaluate the GFAP expression in a fetal rat model of dysraphism and the effect of corticosteroid treatment on this marker and on clinical neurological disabilities . - pubmed
RESULTS : All fetuses with MM in group 1 presented neurological deficits and glial reactions with GFAP expression , as opposed to controls and shams . - pubmed
In group 2 , corticosteroid treatment prevented some neurological deficits ( 18 - 25 % ) , reducing glial response and GFAP expression . - pubmed
CONCLUSIONS : Experimentally induced dysraphism in the rat fetus is related to glial response and increased GFAP expression in the spinal cord . - pubmed
Notably , irregularities in the expression of hnRNP A18 , B1 , K , P2 and L have been linked to cancer and radiosensitivity . - pubmed
The cell cycle checkpoint status ( p21 , p27 , p16 , Tp53 ) , cell dynamics ( proliferating cell nuclear antigen , Ki-67 , terminal deoxynucleotidyl transferase - mediated dUTP - biotin nick - end labeling , M30 ) , DNA damage ( gamma - H2AX [ H2A histone family , member X ] ) , telomere lengths , chromosomal instability ( micronuclei index ) , and senescence - associated beta - galactosidase ( SA - beta - Gal ) activity were evaluated using an in situ approach and compared to those in normal liver ( n = 5 ) and liver with chronic cholestasis ( 34 cases of hepatolithiasis and three cases of primary biliary cirrhosis ) . - pubmed
In HBV - related cirrhosis , the p21 , p27 , and p16 cell cycle checkpoint markers were activated in normal - looking cirrhotic hepatocytes ( NLCH ) , but diminished gradually from LLCC , SLCC , to HCC , with an increase in Tp53 expression . - pubmed
Micronuclei , gamma - H2AX foci , and net cellular gain were significantly increased from normal hepatocytes , NLCH , LLCC , SLCC , to HCC . - pubmed
HBV - related LLCC showed significantly higher Tp53 labeling index , gamma - H2AX labeling index , and micronuclei index ; shorter telomere length ; decreased SA - beta - Gal activity ; and increased net cellular gain compared to cholestatic LLCC . - pubmed
Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma . - pubmed
A correlation between MYCN and polycomb protein Bmi1 expression was observed in primary NB tumors . - pubmed
Intriguingly , the above - mentioned Bmi1 - related regulation of the NB cell phenotype seems not to be mediated only by p14ARF / p16INK4a in NB cells . - pubmed
Expression profiling analysis using a tumor - specific cDNA microarray addressed the Bmi1 - dependent repression of KIF1Bbeta and TSLC1 , which have important roles in predicting the prognosis of NB . - pubmed
These findings suggest that MYCN induces Bmi1 expression , resulting in the repression of tumor suppressors through Polycomb group gene - mediated epigenetic chromosome modification . - pubmed
NB cell proliferation and differentiation seem to be partially dependent on the MYCN / Bmi1 / tumor - suppressor pathways . - pubmed
Further studies are needed to define the cause of the age - related increase in serum sclerostin levels in humans as well as the potential role of this increase in mediating the known age - related impairment in bone formation . - pubmed
The cellular immunity was evaluated using neutrophil adhesion test , cyclophosphamide induced neutropenia and carbon clearance assay , whereas , humoral immunity was tested by mice lethality test , serum immunoglobulin estimation and indirect haemagglutination assay in animals . - pubmed
Influence of aging and hemorrhage injury on Sirt1 expression : possible role of myc - Sirt1 regulation in mitochondrial function . - pubmed
Thus , induction of Sirt1 is likely to produce salutary effects following T - H induced injury and hence , Sirt1 may be a potential molecular target for translational research in injury resolution . - pubmed
Therefore , aberrant Wnt7a signaling may contribute to neurological disorders in which excitatory signaling is disrupted . - pubmed
METHODS : On the basis of culturing neonatal rat cardiomyocytes , the model of hypoxia - reoxygennation was built by using method of Liquid Paraffin covering , the impact of S1P on apoptosis and p - Akt and mitochondrial membrane potential were studied by using method of Propidine Iodide staining and Western blot and Bhodanmine123 staining . - pubmed
RESULTS : SiP could reduce apoptosis rate ( P & lt ; 0.01 ) and stabilize the mitochondrial membrane potential ( P & lt ; 0.05 ) and improved the level of p - Akt1 ( P & lt ; 0.01 ) in hypoxia / reoxygenation cardiomyocytes significantly . - pubmed
These capabilities were used to examine the response of cancer cells to the presence of a ligand ( CXCL12 ) secreted from surrounding cocultured cells . - pubmed
Extending the reach of BRAF - targeted cancer therapy . - pubmed
Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus . - pubmed
BACKGROUND : Conflicting results regarding changes in mucosal IgA production or in the proportions of IgA plasma cells in the small and large intestines during HIV - infection have been previously reported . - pubmed
Except in individuals repeatedly exposed to HIV-1 but yet remaining uninfected , HIV - specific IgAs are frequently absent in mucosal secretions from HIV - infected patients . - pubmed
However , little is known about the organization and functionality of mucosal B - cell follicles in acute HIV / SIV infection during which a T - dependent IgA response should have been initiated . - pubmed
RESULTS : Plasma IgA level was reduced by 46 % by 28 days post infection ( dpi ) , and no IgA plasma cells were found within germinal centers of Peyer 's Patches and isolated lymphoid follicles . - pubmed
CONCLUSION : Our data provide evidence that SIV is unable to initiate a T - dependent IgA response during the acute phase of infection and favors the production of IgG ( ileum ) or IgM ( duodenum ) plasma cells at the expense of IgA plasma cells . - pubmed
Therefore , an early and generalized default in IgA production takes place during the acute of phase of HIV / SIV infection , which might impair not only the virus - specific antibody response but also IgA responses to other pathogens and vaccines as well . - pubmed
Understanding the mechanisms that impair IgA production during acute HIV / SIV infection is crucial to improve virus - specific response in mucosa and control microbial translocation . - pubmed
Glucocorticoid ameliorates early cardiac dysfunction after coronary microembolization and suppresses TGF - beta1 / Smad3 and CTGF expression . - pubmed
OBJECTIVES : This study was designed to evidence the protective effect of glucocorticoid therapy on cardiac dysfunction after coronary microembolization ( CME ) , and to clarify its mechanism with the expression of transforming growth factor - beta 1 ( TGF - beta1)/Smad3 and connective tissue growth factor ( CTGF ) . - pubmed
PRR11 is a novel gene implicated in cell cycle progression and lung cancer . - pubmed
In the present study , we isolated and identified a novel gene , proline - rich protein 11 ( PRR11 ) , implicated in both cell cycle progression and lung cancer . - pubmed
Our results showed that PRR11 was periodically expressed in a cell cycle - dependent manner , and RNAi - mediated silencing of PRR11 caused significant S phase arrest as well as growth retardation in HeLa cells . - pubmed
Moreover , PRR11 was overexpressed at both mRNA and protein levels in lung cancer tissues as compared with normal lung tissues . - pubmed
Large scale in silico analysis of clinical microarray datasets also indicated that high expression of PRR11 was significantly associated with poor prognosis in lung cancer patients . - pubmed
RNAi - mediated silencing of PRR11 caused S phase arrest , suppressed cellular proliferation , colony formation ability in lung cancer cells and inhibited tumorigenic potential in nude mice . - pubmed
Knockdown of PRR11 also inhibited cell migration and invasion ability in lung cancer cells . - pubmed
Taken together , our results strongly demonstrated that this newly identified gene , PRR11 , had a critical role in both cell cycle progression and tumorigenesis , and might serve as a novel potential target in the diagnosis and/or treatment of human lung cancer . - pubmed
RNA - Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse . - pubmed
Recent observations that several inherited forms of ALS involve the RNA binding proteins TDP43 and FUS raise the question as to whether RNA metabolism is generally disturbed in ALS . - pubmed
Here we conduct whole transcriptome profiling of motor neurons from a mouse strain , transgenic for a mutant human SOD1 ( G85R SOD1 - YFP ) , that develops symptoms of ALS and paralyzes at 5 - 6 months of age . - pubmed
Strenuous exercise promotes changes in salivary IgA and can be associated with a high incidence of upper respiratory tract Infections . - pubmed
Hepatitis Be antigen ( HBeAg)-positive CHB patients whose serum hepatitis B virus ( HBV ) DNA remained detectable despite at least 6 mo of LAM + ADV therapy were included . - pubmed
Expression and biological role of cytoglobin in human ovarian cancer . - pubmed
Loss of cytoglobin is found to be involved in the progression of several human cancers . - pubmed
In this study , we examined cytoglobin expression in 118 archived ovarian cancer specimens using immunohistochemistry . - pubmed
cytoglobin downregulation positively correlated with advanced FIGO stage and tumor grade . - pubmed
In conclusion , cytoglobin is downregulated in ovarian cancers and associated with advanced stage . - pubmed
Our data provides evidence that cytoglobin regulates the ovarian cancer cell proliferation and invasion . - pubmed
Cross - species analysis of genetically engineered mouse models of MAPK - driven colorectal cancer identifies hallmarks of the human disease . - pubmed
Here , we describe a collection of genetically engineered mouse models ( GEMMs ) of sporadic CRC that combine lesions frequently altered in human patients , including well - characterized tumor suppressors and activators of MAPK signaling . - pubmed
We provide evidence that a Kras signature derived from these GEMMs is capable of distinguishing human tumors harboring KRAS mutation , and tracks with poor prognosis in two independent human patient cohorts . - pubmed
Furthermore , the analysis of a panel of human CRC cell lines suggests that high expression of the GEMM Kras signature correlates with sensitivity to targeted pathway inhibitors . - pubmed
Few studies have compared treatment patterns , healthcare resource utilization ( HRU ) , and costs in patients with metastatic breast cancer ( mBC ) receiving HER2 directed therapy . - pubmed
BACKGROUND AND OBJECTIVE : Two prognostic models to predict overall survival and thrombosis - free survival have been proposed : International Prognostic Score for Essential Thrombocythemia ( IPSET ) and IPSET - Thrombosis , respectively , based on age , leukocytes count , history of previous thrombosis , the presence of cardiovascular risk factors and the JAK2 mutational status . - pubmed
PATIENTS AND METHODS : We have evaluated the clinical data and the mutation status of JAK2 , MPL and calreticulin of 214 ET patients diagnosed in a single center between 1985 and 2012 , classified according to classical risk stratification , IPSET and IPSET - Thrombosis . - pubmed
Both platelet- and endothelial cell - derived ERp5 support thrombus formation in a laser - induced mouse model of thrombosis . - pubmed
Protein disulfide isomerase ( PDI ) and endoplasmic reticulum protein 57 ( ERp57 ) are emerging as important regulators of thrombus formation . - pubmed
We show here the involvement of ERp5 in thrombus formation using the mouse laser - injury model of thrombosis and a specific antibody raised against recombinant ERp5 . - pubmed
ERp5 release at the thrombus site was detected after infusion of Alexa Fluor 488 - labeled anti - ERp5 antibody at 0.05 mug / g body weight , a dose that does not inhibit thrombus formation . - pubmed
Anti - ERp5 at 3 mug / g body weight inhibited laser - induced thrombus formation in vivo by causing a 70 % decrease in the deposition of platelets and a 62 % decrease in fibrin accumulation compared to infusion of control antibody ( P & lt ; .01 ) . - pubmed
These results provide evidence for a novel role of ERp5 in thrombus formation , a function that may be mediated through its association with alphaIIbbeta3 . - pubmed
In fact , clinical studies revealed increased levels of N / OFQ under sepsis , arthritis , and Parkinson ' s disease . - pubmed
Preclinical and clinical studies pointed to the blockade of NOP receptor signaling as successful strategy for the treatment of inflammatory diseases . - pubmed
Activation of peripheral KCNQ channels relieves gout pain . - pubmed
Our data indicate that activation of peripheral KCNQ channels mediates the pain relief effects of BBR , potentially providing a new strategy for the development of more effective therapies for gout . - pubmed
Soluble receptors for advanced glycation end products and receptor activator of NF - kappaB ligand serum levels as markers of premature labor . - pubmed
BACKGROUND : This study aimed to determine the relationships between secretory and endogenous secretory receptors for advanced glycation end products ( sRAGE , esRAGE ) , sRANKL , osteoprotegerin and the interval from diagnosis of threatened premature labor or premature rupture of the fetal membranes to delivery , and to evaluate the prognostic values of the assessed parameters for preterm birth . - pubmed
The sensitivities of sRANKL and sRAGE levels for predicting preterm delivery were 0.895 and 0.929 with a negative predictive value ( NPV ) of 0.857 and 0.929 , respectively . - pubmed
Cerdulatinib , a novel dual SYK / JAK kinase inhibitor , has broad anti - tumor activity in both ABC and GCB types of diffuse large B cell lymphoma . - pubmed
B - cell receptor ( BCR ) and JAK / STAT pathways play critical roles in diffuse large B - cell lymphoma ( DLBCL ) . - pubmed
Herein , we investigated the anti - lymphoma activity of cerdulatinib , a novel compound that dually targets SYK and JAK / STAT pathways . - pubmed
On a tissue microarray of 62 primary DLBCL tumors , 58 % expressed either phosphorylated SYK or STAT3 or both . - pubmed
Importantly , JAK / STAT and BCR signaling can be blocked by cerdulatinib in primary GCB and non - GCB DLBCL tumor cells that were accompanied by cell death . - pubmed
Our work provides mechanistic insights into the actions of cerdulatinib , suggesting that the drug has a broad anti - tumor activity in both ABC and GCB DLBCL , at least in part by inhibiting SYK and JAK pathways . - pubmed
Rapid Capture Next - Generation Sequencing in Clinical Diagnostics of Kinase Pathway Aberrations in B - Cell Precursor ALL . - pubmed
Comprehensive next - generation sequencing ( NGS ) applications have recently identified various recurrent kinase and cytokine receptor rearrangements in Ph - like B - cell precursor ( BCP ) acute lymphoblastic leukemia ( ALL ) amenable to tyrosin kinase inhibitor treatment . - pubmed
Using a standardized bioinformatics algorithm , we identified kinase and cytokine receptor rearrangements in the majority of ALL patients with high burden of postinduction MRD and enrichment of IKZF1 mutation or deletion ( IKZF1(del ) ) . - pubmed
To investigate the possibility that potassium channels also have a role in the cellular response to cisplatin , we examined the effect of cisplatin on the activity of potassium channels on CT26 cell , the colon carcinoma cell line . - pubmed
RESULTS : Stretozotocin ( STZ ) only - treated groups exhibited hyperglycemia , polydipsia , polyuria , weight loss , glucose intolerance , low fasting plasma insulin and reduced hepatic glycogen content compared to the control group . - pubmed
miR-130b , an onco - miRNA in bladder cancer , is directly regulated by NF - kappaB and sustains NF - kappaB activation by decreasing Cylindromatosis expression . - pubmed
Persistent activation of NF - kappaB signaling is closely related to chronic inflammation and tumorigenesis . - pubmed
However , in cancer cells , NF - kappaB may override these feedbacks through special pathways and lead to the sustained activation . - pubmed
Importantly , we verify that , through deceasing the expression of Cylindromatosis ( CYLD ) , a K63 - specific DUB and endogenous blocker of NF - kappaB signaling , miR-130b can in return sustain the persistent activation of NF - kappaB , which may promote the malignant progression of TCC . - pubmed
Thus , the present study uncovers a potential signaling transduction in which NF - kappaB is continuously activated , and may provide a novel therapeutic approach for the clinical management of TCC . - pubmed
Together these findings reveal that RORalpha regulates macrophage M2 polarization via activation of AMPKalpha , which may provide a novel beneficial effect of RORalpha against inflammation . - pubmed
Editorial Comment to Risk stratification using Bmi-1 and Snail expression is a useful prognostic tool for patients with upper tract urothelial carcinoma . - pubmed
Membrane - type 1 matrix metalloproteinase ( MT1 - MMP ) is a membrane - bound MMP that is highly expressed in cells with invading capacity , including fibroblasts and invasive cancer cells . - pubmed
This DDR2 - mediated mechanism is only present in non - transformed mesenchymal cells as collagen - induced MT1 - MMP activation in HT1080 fibrosarcoma cells and MT1 - MMP function in MDA - MB231 breast cancer cells were not affected by DDR kinase inhibition . - pubmed
Amylin receptor ligands reduce the pathological cascade of Alzheimer ' s disease . - pubmed
Since amylin and amyloid - beta peptide ( Abeta ) share similar beta sheet secondary structure despite not having the same primary sequences , we hypothesized that the accumulation of Abeta in the brains of subjects with Alzheimer ' s disease ( AD ) might compete with amylin for binding to the amylin receptor ( AmR ) . - pubmed
If true , adding exogenous amylin type peptides would compete with Abeta and reduce the AD pathological cascade , improving cognition . - pubmed
Here we report that a 10 - week course of peripheral treatment with human amylin significantly reduced multiple different markers associated with AD pathology , including reducing levels of phospho - tau , insoluble tau , two inflammatory markers ( Iba1 and CD68 ) , as well as cerebral Abeta . - pubmed
Amylin treatment also led to improvements in learning and memory in two AD mouse models . - pubmed
This is the first report documenting the ability of amylin treatment to reduce tauopathy and inflammation in animal models of AD . - pubmed
The data suggest that the clinical analog of amylin , pramlintide , might exhibit utility as a therapeutic agent for AD and other neurodegenerative diseases . - pubmed
In the present study , we identified a cellular factor , VDAC1 , which was upregulated during IBDV infection and found to mediate IBDV polymerase activity . - pubmed
We designed the experiments to elucidate the antineuroinflammatory property of MWP in BV2 microglia activated by beta - amyloid ( Abeta ) , which is a characteristic feature of Alzheimer ' s disease ( AD ) . - pubmed
We concluded that MWP could suppress neuroinflammatory responses in Abeta - activated BV2 microglia via the NF - kappaB and ERK / p38 MAPK signaling cascades and could prove an effective therapeutic agent for the prevention and treatment of neuroinflammatory diseases such as AD . - pubmed
In vitro and in vivo effect of PD-1 / PD - L1 blockade on microglia / macrophage activation and T cell subset balance in cryptococcal meningitis . - pubmed
This study aimed to investigate the PD-1/ PD - L1 signaling pathway and its effects the activation of microglia / macrophage and balancing T cell subsets in cryptococcal meningitis ( CM ) . - pubmed
Reducing insulin via conditional partial gene ablation in adults reverses diet - induced weight gain . - pubmed
Excess circulating insulin is associated with obesity in humans and in animal models . - pubmed
Herein , we describe the consequences of inducible , partial insulin gene deletion in a mouse model in which animals have already been made obese by consuming a high - fat diet . - pubmed
A modest reduction in insulin production / secretion was sufficient to cause significant weight loss within 5 wk , with a specific effect on visceral adipose tissue . - pubmed
This result was associated with a reduction in the protein abundance of the lipodystrophy gene polymerase I and transcript release factor ( Ptrf ; Cavin ) in gonadal adipose tissue . - pubmed
This study demonstrates that changes in circulating insulin that are too fine to adversely affect glucose homeostasis nonetheless exert control over adiposity.-Page , M. M. , Skovso , S. , Cen , H. , Chiu , A. P. , Dionne , D. A. , Hutchinson , D. F. , Lim , G. E. , Szabat , M. , Flibotte , S. , Sinha , S. , Nislow , C. , Rodrigues , B. , Johnson , J. D. Reducing insulin via conditional partial gene ablation in adults reverses diet - induced weight gain . - pubmed
Ectopic Expression of Snail and Twist in Ph+ Leukemia Cells Upregulates CD44 Expression and Alters Their Differentiation Potential . - pubmed
TGF - beta1 is released during bone remodeling and plays a role in maintaining leukemic stem cells , as well as being implicated in the epithelial - mesenchymal transition ( EMT ) process in most solid tumors . - pubmed
The surface receptor CD44 is involved in cell adhesion , cell migration , and homing of normal and malignant hematopoietic stem cells . - pubmed
Elevation of CD44 expression is considered a marker for a worse prognosis in most hematological malignancies . - pubmed
We explored the functions of Snail and Twist1 in Ph+ leukemia . - pubmed
Thus EMT modulators affected proliferation , CD44 gene expression and differentiation ability of Ph+ leukemia cells . - pubmed
Through direct sequencing of the genomic DNA of the Wiskott - Aldrich syndrome protein ( WASP ) gene , we identified a novel missense mutation in exon 3 of the patient 's WASP gene ( c. 343 C>T , p. H115 T ) , and the patient was diagnosed with Wiskott - Aldrich syndrome at 3 months after onset . - pubmed
Targeting Bromodomain and Extra - Terminal ( BET ) Family Proteins in Castration - Resistant Prostate Cancer ( CRPC ) . - pubmed
Purpose : Persistent androgen receptor ( AR ) signaling drives castration - resistant prostate cancer ( CRPC ) and confers resistance to AR - targeting therapies . - pubmed
We evaluated how bromodomain and extra - terminal ( BET ) protein inhibitors ( BETi ) abrogate aberrant AR signaling in CRPC.Experimental Design : We determined associations between BET expression , AR - driven transcription , and patient outcome ; and the effect and mechanism by which chemical BETi ( JQ1 and GSK1210151A ; I - BET151 ) and BET family protein knockdown regulates AR - V7 expression and AR signaling in prostate cancer models . - pubmed
Results : Nuclear BRD4 protein expression increases significantly ( P & lt;= 0.01 ) with castration resistance in same patient treatment - naive ( median H - score ; interquartile range : 100 ; 100 - 170 ) and CRPC ( 150 ; 110 - 200 ) biopsies , with higher expression at diagnosis associating with worse outcome ( HR , 3.25 ; 95 % CI , 1.50 - 7.01 ; P & lt;= 0.001 ) . - pubmed
BRD2 , BRD3 , and BRD4 RNA expression in CRPC biopsies correlates with AR - driven transcription ( all P & lt;= 0.001 ) . - pubmed
Furthermore , BETi reduce growth of prostate cancer cells and patient - derived organoids with known AR mutations , AR amplification and AR - V7 expression . - pubmed
Finally , BETi , unlike enzalutamide , decreases persistent AR signaling and growth ( P & lt;= 0.001 ) of a patient - derived xenograft model of CRPC with AR amplification and AR - V7 expression . - pubmed
Angioedema : A Life - threatening Complication of Tissue Plasminogen Activator . - pubmed
It can present with urticaria or anaphylaxis and is usually associated with angiotensin - converting enzyme inhibitors ( ACEis ) , complement deficiencies , or the side effects of tissue plasminogen activator ( tPA ) . - pubmed
Pharmacological manipulation of the growth hormone secretagogue receptor - type 1a ( GHSR-1a ) receptor has therefore received a lot of attention as a strategy to combat disorders of appetite and body weight , including age - related malnutrition and the progressive muscle wasting syndrome known as cachexia . - pubmed
Claudin-7 downregulation induces metastasis and invasion in colorectal cancer via the promotion of epithelial - mesenchymal transition . - pubmed
The dysregulation of the tight junctions ( TJs ) protein claudin-7 is closely related to the development and metastasis of colorectal cancer ( CRC ) . - pubmed
The aim of this study was to investigate the expression of claudin-7 and characterize the relationship between claudin-7 expression and epithelial - mesenchymal transition ( EMT ) in CRC . - pubmed
In this study , the expression of claudin-7 , E - cadherin , vimentin and snail-1 was detected by immunohistochemistry ( IHC ) in a set of 80 CRC specimens comprising 20 specimens each of well - differentiated , moderately differentiated , poorly differentiated and liver metastases tissues . - pubmed
The results revealed that the expression of claudin-7 was downregulated as CRC tissue differentiation grade decreased , and that low claudin-7 expression corresponded to the downregulation of E - cadherin ( r = 0.725 , p & lt ; 0.001 ) and upregulation of vimentin ( r = -0.376 , p = 0.001 ) and snail-1 ( r = -0.599 , p & lt ; 0.001 ) . - pubmed
In conclusion , the expression of claudin-7 in CRC is downregulated as differentiation grade decreases . - pubmed
Claudin-7 downregulation may promote the invasion and metastasis of CRC by regulating EMT . - pubmed
Recurrent self - limited attacks of fever and short - lived inflammation in the serosal membranes , joints , and skin are the leading features of familial Mediterranean fever ( FMF ) , the most common autoinflammatory disorder in the world , transmitted as autosomal recessive trait caused by MEFV gene mutations . - pubmed
Their consequence is an abnormal function of pyrin , a natural repressor of inflammation , apoptosis , and release of cytokines . - pubmed
FMF - related mutant pyrins are hypophosphorylated following RhoA GTPases ' impaired activity and show a propensity to relapsing uncontrolled systemic inflammation with inappropriate response to inflammatory stimuli and leukocyte spread to serosal membranes , joints or skin . - pubmed
Furthermore , FMF phenotype 3 is referred to the presence of two MEFV mutations with neither clinical signs of FMF nor AA amyloidosis . - pubmed
Many recent studies have also shown that anti - interleukin-1 treatment is the best therapeutic option for FMF patients nonresponsive or intolerant to colchicine . - pubmed
In this study , we explored the biological functions of small nucleolar RNA host gene 12 ( SNHG12 ) and investigated the interaction between miR-133b and SNHG12 in the progression of PCa . - pubmed
We detected SNHG12 expression level in PCa cells and tissues , and then analyzed its clinical significance , which revealed that SNHG12 has the potent to predict prognosis of PCa . - pubmed
Bioinformatic analysis revealed that SNHG12 was closely related to the progression of PCa and could target candidate microRNA ( miR-133b ) . - pubmed
After transfecting SNHG12 silencing plasmid and miR-133b mimic / sponge , biological function assays were conducted and results illustrated that SNHG12 associated with miR-133b exerted biological effects on cancer cell growth , migration , and invasion . - pubmed
Direct interactions between miR-133b and SNHG12 have been found and SNHG12 acts as an oncogene to promote tumorigenesis of PCa by sponging tumor suppressor gene miR-133b . - pubmed
HC106A inhibits Mtb survival during hypoxia - induced NRP ; however , HC104A did not inhibit survival during NRP . - pubmed
First maternal uniparental disomy for chromosome 2 with PREPL novel frameshift mutation of congenital myasthenic syndrome 22 in an infant . - pubmed
Eight such cases have already been reported , while maternal uniparental disomy with a PREPL pathogenic mutation has never been involved . - pubmed
CONCLUSION : To date , nine patients with CMS22 have been reported including our patient , and we report the youngest and the first UPD(2)mat with PREPL novel homozygous pathogenic mutation case , which expand the mutation spectrum of PREPL gene . - pubmed
In contrast , Cushing pituitary tumors , both overt and subclinical cases , had higher CD8 + T cells fractions than GH tumors , prolactinomas , hyperthyroid tumors , and silent tumors . - pubmed
The results revealed that body weights , symptom scores , the levels of red blood cell , white blood cell , lymphocyte , spleen and thymus indexes , and three cytokines ( TNF - alpha , IL-6 , IFN - gamma ) in honey - processed Astragalus treated rats were improved in comparison with spleen qi deficiency rats . - pubmed
TP53 Arg72Pro polymorphism and neuroblastoma susceptibility in eastern Chinese children : a three - center case - control study . - pubmed
TP53 is a tumor suppressor gene that regulates cell growth , apoptosis and DNA repair . - pubmed
Previous studies have reported the contribution of TP53 Arg72Pro ( rs1042522 C > G ) polymorphism to pathogenesis of multiple tumors . - pubmed
No significant association was found between the TP53 gene rs1042522 C > G polymorphism and neuroblastoma susceptibility in the overall analysis ( CG vs. CC : adjusted OR=0.92 , 95 % CI=0.70 - 1.22 , P=0.567 ; GG vs. CC : adjusted OR=0.99 , 95 % CI=0.69 - 1.42 , P=0.947 ; CG / GG vs. CC : adjusted OR=0.94 , 95 % CI=0.72 - 1.23 , P=0.639 ; or GG vs. CC / CG : adjusted OR=1.04 , 95 % CI=0.75 - 1.43 , P=0.814 ) and stratified analysis by age , gender , sites of origin , and clinical stages . - pubmed
The TP53 gene rs1042522 C > G polymorphism may not be a risk factor for neuroblastoma in eastern Chinese children . - pubmed
Future studies are needed to confirm this negative result and to reveal additional functional TP53 variants predisposing to neuroblastoma . - pubmed
Day 3 response was achieved in 55 % ( n = 11/20 ) , with significant reductions in stool frequency , rectal bleeding and CRP ( P < 0.01 ) . - pubmed
Vascular endothelial growth factor ( VEGF ) is an angiogenesis - promoting factor that can mediate allergic airway inflammation and can promote airway epithelial cells ( AECs ) proliferation , but it is not clear whether it affects the engulfment of apoptotic cells by AECs . - pubmed
Since engulfment of apoptotic cells by AECs is an important mechanism for airway inflammation regression , VEGF inhibition of the engulfment of apoptotic cells by airway epithelial cells may be important for mediating allergic airway inflammation . - pubmed
PTSD is associated with increased DNA methylation across regions ofHLA - DPB1 and SPATC1L. - pubmed
This study supports an emerging literature linking PTSD risk to genetic and epigenetic variation in the HLA region . - pubmed
FNDC1 Promotes the Invasiveness of Gastric Cancer via Wnt / beta - Catenin Signaling Pathway and Correlates With Peritoneal Metastasis and Prognosis . - pubmed
Our previous study found that FNDC1 has a higher frequency of mutations in patients with PM by high - throughput sequencing assay , suggesting that it may be associated with GC invasion and PM , however the specific mechanism remains unclear . - pubmed
Methods : First , the correlation between FNDC1 and PM and prognosis of GC was clarified by bioinformatics and clinicopathological analysis . - pubmed
Next , the effect of FNDC1 expression on the invasion and metastasis ability of GC was investigated in vivo and in vitro . - pubmed
Results : FNDC1 was highly expressed in GC and was associated with PM and poor prognosis . - pubmed
FNDC1 was also associated with epithelial - mesenchymal transition ( EMT ) in GC cells . - pubmed
Through in vivo and in vitro experiments , it was clarified that knockdown of FNDC1 could inhibit the proliferation , invasion , and migration of GC cells . - pubmed
Conclusion : FNDC1 may be associated with the invasion of GC and PM after surgery . - pubmed
FNDC1 was highly expressed in GC tissues and cell lines , while significantly associated with poor DFS and OS in GC patients . - pubmed
Both univariate and multivariate analyses suggested that the expression of FNDC1 was an independent factor for GC . - pubmed
FNDC1 may promote EMT in GC cells through the regulation of Wnt / beta - catenin signaling pathway . - pubmed
FNDC1 has the potential to be used as a predictor of PM and may also be studied in depth as a therapeutic target for GC , which has potential clinical utility and is worthy of further validation . - pubmed
The histaminergic system , corticotropin - releasing hormone , cyclic GMP - protein kinase G pathway , and intercellular communication in the cerebellar immune system were some of the most relevant enriched pathways in HA rats . - pubmed
[ Immunoglobulins of the bronchial mucosa in acquired bronchiectasis and in bronchopulmonary carcinomas ] . - pubmed
Adrenocorticotrophin responses to hypoxaemia in fetal sheep are sustained in the presence of naloxone . - pubmed
We have examined the effects of fetal hypoxaemia , produced by reducing the percent oxygen in maternal inspired air , on fetal plasma concentrations of corticotrophin releasing hormone ( CRH ) , adrenocorticotrophin ( ACTH ) and cortisol and determined the effects of an opioid receptor antagonist , naloxone on these responses . - pubmed
Hypoxaemia ( fetal PO2 , 15 - 18 mmHg ) for 60 min provoked a significant ( P & lt ; 0.05 ) increase in fetal plasma ACTH and cortisol concentrations at days 125 - 130 of pregnancy , but did not affect circulating CRH . - pubmed
There was no effect of naloxone administered either intravenously ( 1.25 mg bolus followed by a 2.5 mg / h continuous infusion for one hour ; fetal body weight approximately 2.5 Kg ) or via the lateral cerebral ventricle ( 50 micrograms bolus followed by a 100 micrograms / h infusion for one hour ) on this pattern of ACTH and cortisol change nor on the lack of CRH response to hypoxaemia . - pubmed
We conclude that the increase in fetal ACTH and cortisol in response to acute hypoxaemia is not accompanied by an increase in systemic CRH concentrations , nor is the response dependent on short - term opioid regulation . - pubmed
Relationship between somatomedin - C and growth hormone levels in acromegaly : basal and dynamic evaluation . - pubmed
The relationship between basal and stimulated plasma GH and somatomedin - C ( SmC ) levels in acromegalic patients was evaluated . - pubmed
Our data indicate an overall dependency of plasma SmC levels on plasma GH levels in acromegaly , although similar GH levels may have differing somatomedin - stimulating activities . - pubmed
In evaluating pharmacological or surgical treatments of acromegaly , a single plasma SmC value can reliably replace several plasma GH determinations . - pubmed
Thus , lymphocytapheresis may be an alternative therapy for cases of severe aplastic anemia for those patients who have no compatible donor for bone marrow transplantation and when antithymus globulin is not available . - pubmed
Coagulase - negative staphylococcal sepsis in infants . - pubmed
Estrogen and progesterone receptors are not increased in generalized essential telangiectasia . - pubmed
[ Study of serum pepsinogen fractions in patients with duodenal ulcer ] . - pubmed
[ Behavior of factor XIII in progressive chronic polyarthritis ] . - pubmed
[ Can growth - stimulating immunoglobulins ( TGI ) explain sporadic euthyroid goiters ? ] - pubmed
In patients with primary myxoedema and thyroid atrophy , existence of TGI - blocking IgGs has also been demonstrated . - pubmed
These observations raise several points : --relationship of TGI to other thyroid antibodies , specially to anti - TSH receptor antibodies ; --is " simple " goitre , either diffuse or nodular , an auto - immune thyroid disorder ? - pubmed
Ribonucleotide reductase in cultured mouse lymphoma cells . - pubmed
The pif region of the F factor includes two genes , pifA and pifB , that lead to abortive T7 infection . - pubmed
Bicistronic retroviral vector reveals capacity of v - erbA to induce erythroleukemia and to co - operate with v - myb . - pubmed
In contrast , no leukemia was observed with a myb IRES virus , with spliced vectors containing v - erbA alone or v - erbA in combination with v - myb , nor with erbA IRES and erbA / myb IRES viruses produced in the absence of helper virus . - pubmed
These results show that v - erbA is capable of inducing an erythroleukemia when expressed by a high titer bicistronic retrovirus under conditions of virus spreading and that its in vitro and in vivo transforming potential can be enhanced by v - myb . - pubmed
Alkaloidal glycosidase inhibitors ( AGIs ) as the cause of sporadic scrapie , and the potential treatment of both transmissible spongiform encephalopathies ( TSEs ) and human immunodeficiency virus ( HIV ) infection . - pubmed
As HIV infection progresses , infected clone numbers rise , the antigenic diversity of gp120 may rise as would antibody production , trying to keep pace . - pubmed
Approximately 60 % of patients with SMS have high titers of autoantibodies against the enzyme glutamic acid decarboxylase . - pubmed
Similar to SMS , the majority of patients with IDDM have autoantibodies against glutamic acid decarboxylase at or before diabetes onset , although usually at a lower titer and with a different reaction pattern than patients with SMS . - pubmed
Patients with SMS carried the IDDM - protective DQB1 * 0602 allele and other sequence - related DQB1 * 06 alleles with the same frequency observed in controls . - pubmed
Five of 8 ( 62.5 % ) SMS patients lacking a DQB1 * 06 allele were diabetic in contrast to only 2 of 10 ( 20 % ) with a DQB1 * 06 allele ( P = 0.08 ) , suggesting that the presence of DQB1 * 0602 or other DQB1 * 06 alleles may be associated with a reduced prevalence of diabetes among patients with SMS . - pubmed
Investigation of methylation at Hha I sites using the hypervariable probe M27 beta allows improved clonal analysis in myeloid leukaemia and demonstrates differences in methylation between leukaemic and remission samples . - pubmed
A monoclonal or oligoclonal pattern could be obtained by digestion with Hha I in 18/22 ( 82 % ) patients with acute myeloid leukaemia who had previously shown hypermethylation of both alleles using Hpa II , although in six of these patients differences in methylation could still be demonstrated between leukaemic and remission samples . - pubmed
The studies also provide useful reagents for the molecular genetic analysis of the role of the topoisomerase within the context of vaccinia virus infection . - pubmed
We refer a case of a 57 - year - old woman with an acute myocardial infarction of the anterior wall , treated with rt - PA , aspirin and heparin . - pubmed
The aim of this work was to investigate whether free radical reactions play a role in beta - amyloid neurotoxicity . - pubmed
In these conditions , where only the longest exposure induced neuronal death , superoxide dismutase activity was increased after acute exposure but no change was detected after chronic treatments , whereas a different pattern was observed for glutathione peroxidase . - pubmed
In conclusion , our results show that oxidative stress and free radical production are linked to beta 25 - 35 exposure and may contribute to neurodegenerative events associated with beta - amyloid deposits in Alzheimer ' s disease . - pubmed
Increased transforming growth factor beta ( TGF - beta ) immunoreactivity is independently associated with chronic injury in both consequential and primary radiation enteropathy . - pubmed
PURPOSE : Radiation enteropathy is characterized by sustained increase in transforming growth factor beta ( TGF - beta ) immunoreactivity and connective tissue mast cell ( CTMC ) hyperplasia that may be responsible for progressive fibrosis and lead to clinical complications . - pubmed
Histopathologic changes were assessed with a radiation injury scoring system ( RIS ) , total TGF - beta immunoreactivity was quantified with computerized image analysis , and CTMC hyperplasia was assessed in toluidine blue - stained sections . - pubmed
RESULTS : TGF - beta immunoreactivity and CTMC hyperplasia colocalized in areas of injury and were highly significantly correlated . - pubmed
Increased fraction size and decreased overall treatment time were associated with increased RIS ( p & lt ; 0.01 and p & lt ; 0.00001 ) , increased TGF - beta immunoreactivity ( p = 0.01 andp & lt ; 0.001 ) , and degree of CTMC hyperplasia ( p = 0.01 and p & lt ; 0.001 ) . - pubmed
TGF - beta immunoreactivity was independently associated with chronic intestinal wall fibrosis ( p = 0.003 ) . - pubmed
CONCLUSION : This in vivo study supports in vitro evidence linking increased TGF - beta immunoreactivity and mast cell hyperplasia and strongly suggests their involvement in the molecular pathogenesis of both primary and consequential radiation enteropathy . - pubmed
Tissue factor is the primary cellular initiator of blood coagulation via interaction with coagulation factor VII . - pubmed
Aberrant expression of tissue factor is responsible for thrombosis during septic shock , atherosclerosis and cancer . - pubmed
However , neither IL-1 alpha nor IL-1 beta are neurotoxic per se in vivo , so other IL-1 related ligands may be important in neurodegeneration . - pubmed
The cytokine interleukin-18 ( also called interferon gamma inducing factor , IGIF ) was first isolated from the liver of mice during toxic shock . - pubmed
These data indicate a role for Fas - mediated signaling in the programmed cell death that occurs in response to H. - pubmed
For stage II patients tumor MYCN gene amplication , unfavorable histopathology , an age greater than 2 years , and positive lymph nodes predicted a lower OS ( P & lt;.05 ) . - pubmed
In children with localized neuroblastoma , a subset of patients that are at higher risk for death can be defined as those with stage II disease who have tumor MYCN amplification or who are & gt;/= 2 years of age with either unfavorable histopathology or positive lymph nodes . - pubmed
Mutations in the chloride channel , ClC-5 , have been described in several inherited diseases that result in the formation of kidney stones . - pubmed
Insulin increases renal sodium reabsorption which may contribute to hypertension . - pubmed
We describe a 73 - year - old patient admitted to our hospital because of fatigue , weight loss , and an increased alkaline phosphatase level . - pubmed
BACKGROUND : Observations in patients with functional mutations of the norepinephrine transporter ( NET ) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance . - pubmed
CONCLUSIONS : Selective NET blockade creates a phenotype that resembles idiopathic orthostatic intolerance . - pubmed
Our study also suggests that NET inhibition might be useful in preventing vasovagal reactions . - pubmed
The analyses of IgH rearrangement prove the clonality of lymphoproliferative disorders giving a powerful approach to the B - cell origin identification of cell proliferation . - pubmed
RESULTS : Cryoglobulinemia was detected in 20 % of all chronic hepatitis C virus infected patients and IgH rearrangement was observed in 10.29 % ( 7/68 ) , 4/7 patients ( 57.14 % ) suffered from cryoglobulinemia . - pubmed
Exercise , diet , and childhood obesity : the GH - IGF - I connection . - pubmed
Observed abnormalities in the growth hormone ( GH )- insulin - like growth factor - I ( IGF - I ) axis in obese adults and the impact of exercise on the GH - IGF - I system are of particular relevance to the growing obese child . - pubmed
As cholinergic mechanisms may be at least partially responsible for hallucinations and delusions in Parkinson ' s disease ( PD ) , we conducted an open study in 8 PD patients to assess the efficacy and tolerability of the cholinesterase inhibitor donepezil , 5 mg at bedtime for two months , in the treatment of these complications . - pubmed
The objective of this study was to investigate the prognostic value of T - cell receptor - delta 1 ( TCR delta 1 ) expression in primary cutaneous T - cell lymphomas . - pubmed
TCR delta 1 cellular expression was assessed in skin biopsy specimens of 104 individuals with cutaneous T - cell lymphoma by immunohistochemistry . - pubmed
TCR delta 1 expression in primary cutaneous lymphomas is an independent prognostic factor associated with decreased survival . - pubmed
Average blood pressure readings , laboratory measures of glycosylated hemoglobin , and information on whether the respondent was taking medication for hypertension or diabetes are used to validate respondents ' reports of high blood pressure and diabetes . - pubmed
Univariate and multivariate analyses predicted systolic and diastolic sodium sensitivity based on interactions among demographic factors ( age , gender , race , body mass index ) and hypertensive type [ low - renin ( LR ) , modulator ( M ) , non - modulator ( NM ) ] . - pubmed
DA-8159 , a new PDE5 Iihibitor , induces penile erection in conscious and acute spinal cord injured rabbits . - pubmed
T9.F gliomas showed dramatic losses of CD4 + CD8 + ( DP ) thymocytes . - pubmed
The toxicity of tumor necrosis factor - alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation : implications for Alzheimer ' s disease . - pubmed
The therapies now approved for HIV - infection inhibit one of two viral - specific enzymes , reversetranscriptase or protease . - pubmed
Differential expression of S100 gene family in human esophageal squamous cell carcinoma . - pubmed
PURPOSE : To study the differential expression of the S100 gene family at the RNA level in human esophageal squamous cell carcinoma ( ESCC ) , and to find the relationship of the S100 gene family with ESCC . - pubmed
Then , the differential expression of 16 S100 genes was examined by semiquantitative reverse transcription - polymerase chain reaction ( RT - PCR ) in 62 cases of ESCC versus the corresponding normal esophageal mucosa . - pubmed
RESULTS : Eleven out of 16 S100 genes were significantly downregulated ( p<0.05 ) in ESCC versus the normal counterparts such as S100A1 , S100A2 , S100A4 , S100A8 , S100A9 , S100A10 , S100A11 , S100A12 , S100A14 , S100B , and S100P genes . - pubmed
Moreover , the S100B gene was significantly correlated with histological differentiation of ESCC ( p=0.0247 ) , and the deregulation of some S100 genes was closely correlated ( p<0.05 ) , such as S100A10 / S100A11 , S100A2 / S100A8 , S100A2 / S100A14 , S100A8 / S100A14 , and S100A2 / S100P etc . - pubmed
CONCLUSIONS : The S100 gene family is closely associated with ESCC . - pubmed
Gene therapy using replication - defective herpes simplex virus vectors expressing nerve growth factor in a rat model of diabetic cystopathy . - pubmed
In the present study , the effects of gene therapy , using replication - defective herpes simplex virus type 1 ( HSV-1 ) vectors to deliver and express the nerve growth factor ( NGF ) gene ( HSV - NGF ) on tissue NGF levels and bladder function , were evaluated in streptozotocin ( STZ)-induced diabetic rats . - pubmed
Diabetic rats exhibited a significant decrease in NGF levels in the bladder and lumbosacral dorsal root ganglia ( DRG ) detected by enzyme - linked immunosorbent assay and displayed marked bladder dysfunction 12 weeks after STZ injection . - pubmed
Along with the restoration of tissue NGF expression , in metabolic cage studies and cystometry , HSV - NGF - injected rats also showed significantly reduced bladder capacity and postvoid residual volume than diabetic rats injected with the control vector ( HSV - lacZ ) , indicating that voiding function was improved after HSV vector - mediated NGF gene delivery . - pubmed
Thus , HSV vector - mediated NGF gene therapy may prove useful to restore decreased NGF expression in the bladder and bladder afferent pathways , thereby improving hypoactive bladder function in diabetes . - pubmed
Single nucleotide polymorphisms of the IL18 gene are associated with atopic eczema . - pubmed
BACKGROUND : Human IL-18 is an inflammatory cytokine that plays a role in atopic diseases , such as atopic eczema ( AE ) , by enhancing IL-4 and IL-13 production and stimulating the synthesis of IgE. - pubmed
OBJECTIVE : To evaluate associations of polymorphisms in the IL18 gene on chromosome 11q22 with AE , we performed genotyping for single nucleotide polymorphisms ( SNPs ) in the IL18 gene in 225 patients with AE and 175 healthy control volunteers . - pubmed
On the functional level , the amount of IL-18 in the supernatants of PBMCs of patients with AE stimulated with Staphylococcus aureus enterotoxin B was significantly higher than that in healthy control subjects . - pubmed
In parallel , the amount of active IL-18 in the sera of patients with AE was enhanced at the exacerbation of their disease . - pubmed
CONCLUSION : In conclusion , our data suggest that SNPs in the IL18 gene might be involved in the development of AE by contributing to a functional dysregulation of the IL-18 production in vivo . - pubmed
Production of indoleamine 2,3 - dioxygenase ( IDO ) by tumor cells , leading to tryptophan depletion and production of immunosuppressive metabolites , may facilitate immune tolerance of cancer . - pubmed
Patients who enrolled in the analyzed trials were aged & gt ; or = 15 years with chronic plaque psoriasis for & gt ; or = 12 months that involved & gt ; or = 10 % of body surface area , and CD4 + T lymphocyte counts above the lower limit of normal ( & gt;404 cells / microL ) . - pubmed
The incidence of infections was stratified according to CD4 + T lymphocyte counts ( & lt;250 cells / microL vs & gt ; or = 250 cells / microL ) . - pubmed
The incidence of infections appeared to be unrelated to CD4 + T lymphocyte counts . - pubmed
Production of monoclonal antibodies specific for native equine IgE and their application to monitor total serum IgE responses in Icelandic and non - Icelandic horses with insect bite dermal hypersensitivity . - pubmed
IgE and mast cells have a central role in immunity to parasites and the pathogenesis of allergic diseases in horses and other mammals . - pubmed
Total serum IgE of healthy horses was compared with that of horses with insect bite dermal hypersensitivity ( IBDH ) an allergic reaction to the bites of blood feeding insects of Culicoides or Simulium spp . - pubmed
In the present study Icelandic horses with IBDH had significantly higher total IgE than healthy Icelandic horse controls ( P<0.05 ) . - pubmed
By contrast in horses of other breeds the difference in total serum IgE between those affected with IBDH and healthy controls was not statistically significant . - pubmed
Thereafter the total serum IgE remained low in Icelandic horses that remained healthy but rose significantly ( P<0.05 ) in those that developed IBDH . - pubmed
The survival neurons in the hippocampal CA1 region were less ( 100 + /- 27 / mm vs 183 + /- 8 / mm ; P & lt ; 0.05 ) , as well as the AchE - positive unit and NOS - positive neurons ( 18.50 + /- 2.24 % vs 27.50 + /- 2.18 % and 19.25 + /- 4.33 vs 33.75 + /- 5.57 respectively ; P & lt ; 0.05 ) after HIBD . - pubmed
Thiorphan , a neutral endopeptidase inhibitor used for diarrhoea , is neuroprotective in newborn mice . - pubmed
Racecadotril , which is rapidly metabolized to its active metabolite thiorphan , is a neutral endopeptidase ( NEP ) inhibitor used in clinical practice for diarrhoea with a remarkable safety profile . - pubmed
Intraperitoneal administration of thiorphan reduced ibotenate - induced cortical lesions by up to 57 % and cortical caspase-3 cleavage by up to 59 % . - pubmed
Further supporting the neuroprotective effect of pharmacological blockade of NEP , mouse pups with a genetic deletion of NEP displayed a significantly reduced size of the ibotenate - induced cortical grey matter lesion when compared with wild - type animals . - pubmed
Recent genetic evidence has linked mutations in hTHTR1 with the manifestation of TRMA ( thiamine - responsive megaloblastic anaemia ) , a condition also associated with diabetes mellitus , sensorineural deafness and retinal disorders . - pubmed
To examine how mutations in hTHTR1 impair thiamine accumulation , we have investigated the targeting and functional properties of several different hTHTR1 mutants in human cell lines derived from epithelia relevant to thiamine absorption or tissues implicated in TRMA pathology . - pubmed
These constructs encompassed two newly identified point mutations ( P51L and T158R ) and two truncations of hTHTR1 identical with those found in TRMA kindreds ( W358X and Delta383fs ) . - pubmed
[ Detection of multidrug resistance - associated proteins MRP2 , MRP3 , and MRP5 mRNA expressions in hepatocarcinoma cells using SYBR real - time PCR ] . - pubmed
CONCLUSION : MRP2 might play a role in the intrinsic drug resistance , and MRP3 and MRP5 are related to the acquired drug resistance of hepatocellular carcinoma . - pubmed
Treatment with apo B peptide vaccines inhibits atherosclerosis in human apo B-100 transgenic mice without inducing an increase in peptide - specific antibodies . - pubmed
DESIGN : LDL receptor(-/-)/human apo B-100 transgenic mice were immunized with native human apo B-100 peptides p45 or p210 at 6 , 9 and 11 weeks and the extent of atherosclerosis determined by en face Oil Red O staining of the aorta at 25 weeks . - pubmed
Immunization with native p45 and p210 reduced atherosclerosis by 66 % ( P & lt ; 0.02 ) and 59 % ( P = 0.06 ) , respectively . - pubmed
CONCLUSIONS : Immunization with apo B peptide - based vaccines inhibits atherosclerosis in mice expressing human apo B-100 suggesting that they can interact with their target as expressed in humans . - pubmed
[ The relationship between apolipoprotein E genotype and hypertriglyceridemia - associated recurrent acute pancreatitis ] . - pubmed
OBJECTIVE : To explore the relationship of apolipoprotein E ( ApoE ) genotype with hypertriglyceridemia - associated recurrent acute pancreatitis . - pubmed
METHODS : Taking the fasting serum triglyceride ( TG ) level & gt ; or = 2.3 mmol / L as hypertriglyceridemia , ApoE genotypes in 115 patients with hypertriglyceridemia - associated recurrent acute pancreatitis were assessed by polymerase chain reaction . - pubmed
CONCLUSIONS : Apo epsilon 2 and epsilon 4 alleles are closely related to moderate - severe hypertriglyceridemia - associated recurrent acute pancreatitis . - pubmed
Silencing of lToll did not impair the ability of non - specific dsRNA to trigger protection from white spot syndrome virus and did not increase the shrimp susceptibility to viral infection , when compared to controls . - pubmed
It has been shown that diabetes - induced fetal abnormalities are accompanied by some metabolic disturbances including elevated superoxide dismutase ( SOD ) activity , reduced levels of myoinositol and arachidonic acid and inhibition of the pentose phosphate shunt pathway . - pubmed
METHODS : Rabbit cells from NP and AF were isolated and their phenotype was compared with that of AC by real - time PCR analysis of type I ( COL1A1 ) , II ( COL2A1 ) and V ( COL5A1 ) collagens , aggrecan transcript ( AGC1 ) , matrix Gla protein ( MGP ) and Htra serine peptidase 1 ( Htra1 ) . - pubmed
RESULTS : Transcript analysis indicated that despite certain similarities , IVD cells exhibit distinct COL2A1 / COL1A1 and COL2A1 / AGC1 ratios as compared with AC . - pubmed
The expression pattern of COL5A1 , MGP and Htra1 makes it possible to define a phenotypic signature for NP and AF cells . - pubmed
Type V collagen , MGP and HtrA1 could greatly help to discriminate among NP , AF and AC cells . - pubmed
Cellular FLICE - inhibitory protein ( c - FLIP ) signalling : a key regulator of receptor - mediated apoptosis in physiologic context and in cancer . - pubmed
The present review summarizes recent findings concerning c - FLIP proteins ' function and regulation , with a main focus on the c - FLIP ( L ) deregulated expression in cancer . - pubmed
The role of c - FLIP ( L ) as anti - apoptotic pro - survival factor in tumors and the potential utility of this molecule as a possible alternative therapeutic target are discussed . - pubmed
Dysregulation of the receptor activator of NF - kappaB ligand and osteoprotegerin production influence the apoptosis of multiple myeloma patients ' bone marrow stromal cells co - cultured with myeloma cells . - pubmed
Differences in receptor activator of NF - kappaB ligand ( RANKL ) and osteoprotegerin ( OPG ) production in BMSCs derived from MM patients and control subjects and the apoptosis of BMSCs and MM cells in co - cultures of both cell types were examined . - pubmed
Production of soluble RANKL was enhanced and the increase was more significant in the BMSCs of the MM patients than in those of the controls . - pubmed
Disturbances in the RANKL / OPG system are more profound in the BMSCs of MM patients than in those of control subjects after direct contact with RPMI8226 cells . - pubmed
Breaking T cell tolerance against self type II collagen in HLA - DR4 - transgenic mice and development of autoimmune arthritis . - pubmed
OBJECTIVE : To establish a new animal model in DRB1 * 0401 ( DR4)-transgenic mice in which T cell tolerance to self type II collagen ( CII ) can be broken and allow for the development of autoimmune arthritis , to investigate the role of posttranslational modifications of the CII(259 - 273 ) epitope in the induction and breaking of tolerance of DR4 - restricted T cells , and to characterize DR4 - restricted T cell recognition of the immunodominant CII(259 - 273 ) epitope . - pubmed
METHODS : DR4 - transgenic mice expressing either the entire human CII protein ( HuCII ) or only the immunodominant T cell epitope of heterologous CII ( MMC ) in joint cartilage were established on different genetic backgrounds , and susceptibility to collagen - induced arthritis ( CIA ) was tested . - pubmed
CONCLUSION : It is possible to break tolerance to self CII and induce arthritis in DR4 mice . - pubmed
However , arthritis susceptibility is tightly controlled by the genetic background and by the source of the transgenic element for expressing the heterologous CII peptide as a self CII protein in the joint . - pubmed
In contrast to CIA in A(q)-expressing mice , the nonglycosylated CII(259 - 273 ) epitope is clearly immunodominant in both tolerized and nontolerized DR4 mice . - pubmed
This feature led to the clinical development of BoNT - A for a number of neuromuscular disorders . - pubmed
This review explores the mechanistic basis of this analgesic effect , summarizing current knowledge of the structure - function relationship of BoNT and discussing effects on both motor and pain neurons . - pubmed
For a complete picture of the analgesic properties of BoNT - A , clinical evidence of efficacy in myofascial pain and neuropathic pain is considered in tandem with a mechanistic rationale for activity . - pubmed
Patients experiencing chronic pain are clear candidates for treatment with a modified clostridial endopeptidase that would provide enduring inhibition of neurotransmitter release . - pubmed
Regulation of Skp2 expression and activity and its role in cancer progression . - pubmed
Overexpression of Skp2 is associated with a variety of human cancers , indicating that Skp2 may contribute to the development of human cancers . - pubmed
The notion is supported by various genetic mouse models that demonstrate an oncogenic activity of Skp2 and its requirement in cancer progression , suggesting that Skp2 may be a novel and attractive therapeutic target for cancers . - pubmed
Tumor suppressor Pdcd4 is a major transcript that is upregulated during in vivo pancreatic islet neogenesis and is expressed in both beta - cell and ductal cell lines . - pubmed
The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival : a reductase - based peptide counters beta - adrenergic receptor ligand - mediated cardiac dysfunction . - pubmed
This is the first reporting of regulation of HO-2 by BVR and that their coordinated increase in isolated myocytes and intact heart protects against cardiotoxicity of beta - adrenergic receptor activation by isoproterenol ( ISO ) . - pubmed
Finding that BVR and HO-2 levels , myocyte apoptosis , and contractile function of the heart can be modulated by small human BVR - based peptides offers a promising therapeutic approach for treatment of cardiac dysfunctions . - pubmed
Here , we show that epidermal growth factor ( EGF ) induces Toca-1 localization to lamellipodia , where it co - localizes with F - actin and Arp2 / 3 complex in A431 epidermoid carcinoma cells . - pubmed
Lactate dehydrogenase ( LDH ) release assay was used to evaluate NK cell cytotoxicity . - pubmed
The inhibitory effect of ACh on NK cell cytotoxicity was mimicked by pilocarpine , an agonist of muscarinic receptor , and by nicotine , an agonist of nicotinic receptor , at all applied concentrations ( 10(-10 ) - 10(-6 ) mol / L ) . - pubmed
Muscarinic receptor antagonist atropine blocked the inhibitory effect of ACh on the cytotoxicity of NK cells . - pubmed
Nevertheless , tubocurarine , an antagonist of nicotinic receptor , had no blocking effect on the suppression of NK cell cytotoxicity by ACh . - pubmed
CONCLUSION : ACh results in an inhibition of the cytotoxicity of NK cells , and this inhibition is realized mainly through M and N1 cholinergic receptor . - pubmed
Control of NF - kappaB and inflammation by the unfolded protein response . - pubmed
This review summarizes current knowledge on potential mechanisms underlying the biphasic , bidirectional regulation of NF - kappaB by the UPR and possible roles for ER stress in the regulation of inflammation . - pubmed
The protective effect may be mediated through its regulation of apoptosis and activities of T - AOC and ChAT in the hippocampus and cortex of the rats in the chronic cerebral hypoperfusion model , a mechanism that is different from rivastigmine . - pubmed
The metastasis suppressor , N - myc downstream regulated gene-1 ( NDRG1 ) , has been shown to markedly reduce metastasis of numerous tumors . - pubmed
This effect was observed in three different cancer cell types , including PC3MM and DU145 prostate cancer cells and H1299 lung carcinoma cells , and occurred independently of p53 . - pubmed
Examining the mechanisms behind the effect of NDRG1 on p21 expression , we found that NDRG1 upregulated p21 via transcriptional and posttranscriptional mechanisms in prostate cancer cells , although its effect on H1299 cells was posttranscriptional only . - pubmed
Additional functional studies identified that NDRG1 inhibits cancer cell migration , suggesting that p21 is a molecular player in its antimetastatic activity . - pubmed
Poly ( ADP - ribose ) polymerase-1 : a novel therapeutic target in necrotizing enterocolitis . - pubmed
Here , we tested the hypothesis that NO dysregulation in intestinal epithelial cells during NEC leads to marked PARP-1 expression and that administration of a PARP-1 inhibitor ( nicotinamide ) attenuates intestinal injury in a newborn rat model of NEC . - pubmed
We speculate that PARP-1 overactivation in NEC may drive mucosal cell death in this disease and that PARP-1 may be a novel therapeutic target in NEC . - pubmed
Biology of Cox-2 : an application in cancer therapeutics . - pubmed
Molecular pathology studies have revealed that Cox-2 is over - expressed in cancer and stroma cells during tumor progression , and anti - cancer chemo - radiotherapies induce expression of Cox-2 in cancer cells . - pubmed
Elevated tumor Cox-2 is associated with increased angiogenesis , tumor invasion and promotion of tumor cell resistance to apoptosis . - pubmed
Much attention is being focused on Cox-2 inhibitors as beneficial target for cancer chemotherapy . - pubmed
Further clinical application needs to be investigated for comprehending Cox-2 biological functions and establishing it as an effective target in cancer therapy . - pubmed
A proteomics platform combining depletion , multi - lectin affinity chromatography ( M - LAC ) , and isoelectric focusing to study the breast cancer proteome . - pubmed
In addition , potential glycan changes were indicated by comparing proteins in control and cancer samples in terms of their affinity to the multi - lectin column ( M - LAC ) and the pI profiles in IEF separation . - pubmed
In conclusion , a proteomics platform including high abundance protein depletion , lectin affinity fractionation , IEF separation , and LC - MS analysis has been applied to discover breast cancer - associated proteins . - pubmed
Asymmetric cell shapes in the DM epithelium are hypothesized to contribute to the tilt , however , it is unclear what lies downstream of Pitx2 to alter epithelial cell shape . - pubmed
The cells of the left DM epithelium in either Pitx2 or Shroom3 deficient embryos are shorter and wider than those in control embryos and resemble the shape of those on the right , demonstrating that like Pitx2 , Shroom3 is required for cell shape asymmetry and the leftward DM tilt . - pubmed
Because N - cadherin expression is specific to the left side and is Pitx2 dependent , we determined whether Shroom3 and N - cadherin function together to regulate cell shape in the left DM epithelium . - pubmed
Analysis of mouse embryos lacking one allele of both Shroom3 and N - cadherin revealed that they possess shorter and wider left epithelial DM cells when compared with Shroom3 or N - cadherin heterozygous embryos . - pubmed
EBV - LMP1 staining was demonstrated in 41/57 ( 71 % ) of the mixed cellularity and the 19/35 ( 54.2 % ) of nodular sclerosis subtypes . - pubmed
Radiofrequency - assisted liver resection was associated with diminished blood loss ( P & lt ; 0.0001 ) , a lower blood transfusion rate ( P & lt ; 0.005 ) , reduced operative time ( P & lt ; 0.0001 ) , and better postoperative serum albumin levels ( P & lt ; 0.03 ) . - pubmed
Overexpression of the human epidermal growth factor receptor 2 ( HER2 ) predicts a poor prognosis in metastatic breast cancer . - pubmed
While the introduction of HER2 - targeted therapies , such as the monoclonal antibody trastuzumab and the small - molecule tyrosine kinase inhibitor lapatinib , has significantly improved outcomes in HER2 + breast cancer compared with previously available therapies , use of these targeted therapies is often limited by the development of drug resistance and tolerability issues . - pubmed
Recently , several agents have demonstrated promising activity in HER2 + metastatic breast cancer , either as monotherapy or in combination therapy , including the tyrosine - kinase inhibitors neratinib ( HKI-272 ) and afatinib ( BIBW-2992 ) and the anti - HER2 monoclonal antibodies pertuzumab and trastuzumab - DM1 ( T - DM1 ) . - pubmed
Agents that target other molecular pathways , such as the vascular endothelial growth factor receptor , mammalian target of rapamycin , PI3 - kinases , insulin - like growth factor ( IGFR ) , HSP-90 , and other kinases also have potential , in combination with anti - HER2 and/or other systemic therapies , to be active in this subtype of breast cancer . - pubmed
Association between hippocampal volume and serum adiponectin in patients with type 2 diabetes mellitus . - pubmed
The aim of the present study was to test the hypothesis that the level of the adipocytokine adiponectin correlates with hippocampus volume and insulin resistance in patients with type 2 DM . - pubmed
A total of 45 patients with type 2 DM were divided into two groups : a low adiponectin group and a normal adiponectin group . - pubmed
These results suggest that circulating levels of adiponectin are related to hippocampus volume in patients with type 2 DM . - pubmed
Disruption of delta - opioid receptor phosphorylation at threonine 161 attenuates morphine tolerance in rats with CFA - induced inflammatory hypersensitivity . - pubmed
The aim of this study was to assess the function of DOR phosphorylation by Cdk5 in complete Freund 's adjuvant ( CFA)-induced inflammatory pain and morphine tolerance . - pubmed
METHODS : Dorsal root ganglion ( DRG ) neurons of rats with CFA - induced inflammatory pain were acutely dissociated and the biotinylation method was used to explore the membrane localization of phosphorylated DOR at Thr-161 ( pThr-161 - DOR ) , and paw withdrawal latency was measured after intrathecal delivery of drugs or Tat - peptide , using a radiant heat stimulator in rats with CFA - induced inflammatory pain . - pubmed
Intrathecal delivery of the engineered Tat fusion - interefering peptide corresponding to the second intracellular loop of DOR ( Tat - DOR-2L ) increased inflammatory hypersensitivity , and inhibited DOR- but not micro - opioid receptor - mediated spinal analgesia in CFA - treated rats . - pubmed
However , intrathecal delivery of Tat - DOR-2L postponed morphine antinociceptive tolerance in rats with CFA - induced inflammatory pain . - pubmed
CONCLUSION : Phosphorylation of DOR at Thr-161 by Cdk5 attenuates hypersensitivity and potentiates morphine tolerance in rats with CFA - induced inflammatory pain , while disruption of the phosphorylation of DOR at Thr-161 attenuates morphine tolerance . - pubmed
Viral diversity and diversification of major non - structural genes vif , vpr , vpu , tat exon 1 and rev exon 1 during primary HIV-1 subtype C infection . - pubmed
The mean intra - patient diversity was 0.11 % ( 95 % CI ; 0.02 to 0.20 ) for vif , 0.23 % ( 95 % CI ; 0.08 to 0.38 ) for vpr , 0.35 % ( 95 % CI ; -0.05 to 0.75 ) for vpu , 0.18 % ( 95 % CI ; 0.01 to 0.35 ) for tat exon 1 and 0.30 % ( 95 % CI ; 0.02 to 0.58 ) for rev exon 1 during the time period 0 to 90 days p / s. The intra - patient diversity increased gradually in all non - structural genes over the first year of HIV-1 infection , which was evident from the vif mean intra - patient diversity of 0.46 % ( 95 % CI ; 0.28 to 0.64 ) , vpr 0.44 % ( 95 % CI ; 0.24 to 0.64 ) , vpu 0.84 % ( 95 % CI ; 0.55 to 1.13 ) , tat exon 1 0.35 % ( 95 % CI ; 0.14 to 0.56 ) and rev exon 1 0.42 % ( 95 % CI ; 0.18 to 0.66 ) during the time period of 181 to 500 days p / s. There was a statistically significant increase in viral diversity for vif ( p = 0.013 ) and vpu ( p = 0.002 ) . - pubmed
The experimental ICH was induced by intrastriatal administration of bacterial collagenase IV in adult rats . - pubmed
We used three mouse models of pathological ocular neovascularization : oxygen - induced retinopathy ( a mouse model of ischemic retinopathies ) , laser - induced choroidal neovascularization , and a human VEGF transgenic mouse that overexpresses human VEGF specifically in photoreceptor cells and generates pathological neovascularization in the retina . - pubmed
Over - expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model . - pubmed
Compared to those without hearing impairment , patients with hearing impairment had lower serum ferritin levels ( P = 0.01 ) . - pubmed
Lower serum ferritin levels may be associated with hearing impairment . - pubmed
Effectiveness and safety of rabbit anti - thymocyte globulin in Japanese patients with aplastic anemia . - pubmed
RESULTS : In the psoriatic patients without arthritis , serum 25 -( OH ) D levels were inversely correlated with fasting glucose ( r = -0.285 ; P = .026 ) , total cholesterol ( r = -0.440 ; P = .000 ) , low - density lipoprotein ( r = -0.415 ; P = .001 ) , total cholesterol / high - density lipoprotein ( r = -0.303 ; P = .01 ) , and triglyceride ( r = -0.280 ; P = .029 ) values . - pubmed
Clinicopathological and molecular significance of Sumolyation marker ( ubiquitin conjugating enzyme 9 ( UBC9 ) ) expression in breast cancer of black women . - pubmed
In contrast to the well - defined predictive factors for the hormonal therapy , there is a paucity of information on the BRCA1 deficiency breast tumor biology , particularly among African women . - pubmed
BRCA1 Sumoylation ( UBC9 ) has been speculated to be involved in the ER transcription activity , BRCA1 deficiency and triple negative BC . - pubmed
We therefore hypothesized that UBC9 , a SUMOylation marker , may have contributed to the aggressive nature of BRCA1 tumor phenotype observed in Nigerian women . - pubmed
The protein expression of UBC9 , as compared with other biomarkers , showed an inverse correlation with steroid hormones ( ER , progesterone ( PgR ) ) , BRCA1 , p27 , p21 and MDM4 , and a positive correlation with triple negative , basal cytokeratins ( CK14 and CK5 / 6 ) , epidermal growth factor receptor ( EGFR ) , basal - like breast cancer phenotype , p53 , phosphoinositide-3 - kinases ( PI3KCA ) , placental cadherin , ( P - cadherin ) and BRCA1 regulators ( metastasis tumor antigen-1 ( MTA1 ) . - pubmed
Survival analysis showed that those tumors positive for UBC9 expression had a significantly poorer breast cancer - specific survival ( BCSS ) as compared with those showing negative expression . - pubmed
This study demonstrates that UBC9 appears to play an important role in the tumor biology of Nigerian women . - pubmed
Therefore , a novel UBC9 targeted therapy in black women with BC could enhance a better patient outcome . - pubmed
Imaging studies on dopamine transporter and depression : a review of literature and suggestions for future research . - pubmed
We review the conflicting results from imaging studies of dopamine transporter availability in depressed patients and also discuss the heterogeneity of the variables involved . - pubmed
The ESRD patients who underwent hemodialysis had a different flora and showed slightly higher levels of hs - CRP , IL-6 , and plasma endotoxin , compared with those in ESRD patients who did not undergo hemodialysis . - pubmed
Evaluation of nonsurgical periodontal therapy in chronic periodontitis patients with anemia by estimating hematological parameters and high - sensitivity C - reactive protein levels . - pubmed
Certain inflammatory cytokines produced during periodontal inflammation increase the production of acute phase proteins like high - sensitivity C - reactive protein ( hs - CRP ) and can depress erythropoietin production leading to the development of anemia . - pubmed
AIM : The aim of this study is to investigate the efficacy of nonsurgical periodontal therapy on red blood cell ( RBC ) parameters and hs - CRP in chronic periodontitis patients with anemia . - pubmed
A total of 30 subjects with anemia and chronic periodontitis with age group of 33 - 55 years were selected by screening hemoglobin ( Hb ) levels and examining periodontal findings . - pubmed
There is significant decrease in levels of ESR and hs - CRP levels after nonsurgical periodontal therapy indicating resolution of periodontal inflammation . - pubmed
Minimal changes in mean corpuscular volume , mean corpuscular hemoglobin ( MCH ) and MCH concentration indicated that the lower values of red cell parameters are not due to any vitamin and mineral deficiencies , but secondary to the chronic inflammatory changes associated with chronic periodontal disease . - pubmed
CONCLUSION : The present study strengthens the hypothesis that chronic periodontitis may lead to anemia and provides evidence that nonsurgical periodontal therapy can improve the anemic status and reduce levels of hs - CRP in patients with chronic periodontitis . - pubmed
Metallothionein ( MT ) gene therapy leads to resolution of liver fibrosis in mouse model , in which the activation of collagenases is involved in the regression of liver fibrosis . - pubmed
Male Kunming mice subjected to bile duct ligation ( BDL ) resulted in liver fibrosis as assessed by increased alpha - smooth muscle actin ( alpha - SMA ) and collagen I production / deposition in the liver . - pubmed
Therefore , the results demonstrate that zinc supplementation suppresses BDL - induced liver fibrosis through both inhibiting collagen production and enhancing collagen degradation . - pubmed
Compared with ACSF - exposed animals , SCI - elevated [ H2O2 ] significantly increased intracellular protein and DNA oxidation by threefold and MLP by eightfold in neurons , respectively . - pubmed
Therefore , we conclude that ( 1 ) the role of H2O2 in secondary SCI is pro - oxidation and pro - cell death , ( 2 ) apoptosis is a pathway for SCI - elevated [ H2O2 ] to induce cell death , ( 3 ) caspase activation is a mechanism of H2O2 - induced apoptosis after SCI , and ( 4 ) MnTBAP treatment significantly decreased H2O2 - induced oxidation , cell loss , and apoptosis to the levels of ACSF controls , further supporting MnTBAP 's ability to scavenge H2O2 by in vivo evidence . - pubmed
Indeed , such treatment causes a behavioural supersensitivity to dopamine D2 receptor agonists associated with an increase sexual activity and aggressivity ( mania ) . - pubmed
The dopamine receptor sensitization is followed , after imipramine discontinuation , by an opposite phenomenon ( dopamine receptor desensitization ) and an increased immobility time ( depression ) in the forced swimming test of depression . - pubmed
LECs secrete pro - inflammatory cytokines and chemokines to create local inflammatory conditions for recruitment of naive antigen presenting cells ( APCs ) such as dendritic cells ( DCs ) to sites of infection and/or vaccine administration . - pubmed
The confirmed prevalence of hypersensitivity to Hymenoptera stings according to skin tests and in vitro sIgE levels was 0.2 % ( 95 % CI : 0.14 - 0.30 % ) . - pubmed
Tailored anti - TNF therapy during pregnancy in patients with IBD : maternal and fetal safety . - pubmed
OBJECTIVE : Antitumour necrosis factor ( TNF ) during pregnancy in patients with IBD is related to high fetal anti - TNF levels . - pubmed
DESIGN : Two groups of women with IBD were prospectively followed - up during pregnancy : women in sustained remission stopped anti - TNF before week 25 ( stop group ) and the remaining group continued anti - TNF beyond week 30 ( continue group ) . - pubmed
Growth , infection rate , allergies , eczema and adverse reactions to vaccines were comparable across the stop and the continue groups as well as the children of anti - TNF - exposed and non - IBD women at 1 year . - pubmed
CONCLUSIONS : To limit anti - TNF exposure in utero , anti - TNF can be stopped safely in the second trimester in women with IBD in sustained remission . - pubmed
, 95%CI : 1.08 - 2.84 ) , high BP / low HDL - C ( OR:1.68 , 95%CI : 1.05 - 2.60 ) and high WC / low HDL - C ( OR : 2.41 , 95 % CI : 1.37 - 4.23 ) phenotypes were associated with adult MetS. - pubmed
Prognosis , stage and oestrogen receptor status of contralateral breast cancer in relation to characteristics of the first tumour , prior endocrine treatment and radiotherapy . - pubmed
An ER - negative BC2 was associated with an inferior prognosis compared to an ER - positive BC2 regardless of ER - status of BC1 or prior endocrine therapy . - pubmed
Role of HMGB1 in regulation of STAT3 expression in CD4(+ ) T cells from patients with aGVHD after allogeneic hematopoietic stem cell transplantation . - pubmed
HMGB1 is a cytokine mediator of inflammation and an important chromatin protein regulating gene transcription . - pubmed
In this study , we found that the expressions of HMGB1 and STAT3 were higher in CD4(+ ) T cells of patients with aGVHD compared with those without aGVHD , and the HMGB1 expression was positively correlated with the STAT3 expression . - pubmed
We also demonstrated that HMGB1 could regulate the expression of STAT3 by modulation of its DNA methylation in CD4(+ ) T cells , moreover downregulated HMGB1 in aGVHD CD4(+ ) T cells could change the ratio of Treg / Th17 . - pubmed
These data strongly suggest that HMGB1 plays a crucial role in the regulation of Treg / Th17 and progression of aGVHD . - pubmed
BACKGROUND : Early treatment for Crohn ' s disease ( CD ) with immunomodulators and/or anti - TNF agents improves outcomes in comparison to a slower ' step up ' algorithm . - pubmed
Significant variables in the multivariate Cox model included small bowel disease ( HR 2.12 , CI 1.05 - 4.29 ) , left colonic disease ( HR 0.73 , CI 0.49 - 1.09 ) , perianal disease ( HR 4.12 , CI 1.01 - 16.88 ) , ASCA ( HR 1.35 , CI 1.16 - 1.58 ) , Cbir ( HR 1.29 , CI 1.07 - 1.55 ) , ANCA ( HR 0.77 , CI 0.62 - 0.95 ) , and the NOD2 frameshift mutation / SNP13 ( HR 2.13 , CI 1.33 - 3.40 ) . - pubmed
Host control of influenza A virus ( IAV ) is associated with exuberant pulmonary inflammation characterized by the influx of myeloid cells and production of proinflammatory cytokines including interferons ( IFNs ) . - pubmed
Here , we demonstrate that in addition to its known anti - viral activity , STAT1 signaling coordinates host inflammation during IAV infection in mice . - pubmed
Polydatin Protecting Kidneys against Hemorrhagic Shock - Induced Mitochondrial Dysfunction via SIRT1 Activation and p53 Deacetylation . - pubmed
CONCLUSIONS : MD is present in severe HS , and PD can attenuate MD of RTECs via the SIRT1 - p53 pathway . - pubmed
Maternal Embryonic Leucine Zipper Kinase ( MELK ) as a Novel Mediator and Biomarker of Radioresistance in Human Breast Cancer . - pubmed
PURPOSE : While effective targeted therapies exist for estrogen receptor - positive and HER2 - positive breast cancer , no such effective therapies exist for triple - negative breast cancer ( TNBC ) ; thus , it is clear that additional targets for radiosensitization and treatment are critically needed . - pubmed
RESULTS : MELK expression is significantly elevated in breast cancer tissues compared with normal tissue as well as in TNBC compared with non - TNBC . - pubmed
MELK RNA and protein expression is significantly correlated with radioresistance in breast cancer cell lines . - pubmed
Inhibition of MELK ( genetically and pharmacologically ) induces radiation sensitivity in vitro and significantly delayed tumor growth in vivo in multiple models . - pubmed
CONCLUSIONS : Here , we identify MELK as a potential biomarker of radioresistance and target for radiosensitization in TNBC . - pubmed
Our results support the rationale for developing clinical strategies to inhibit MELK as a novel target in TNBC . - pubmed
Isoliquiritigenin suppresses tumor necrosis factor - alpha - induced inflammation via peroxisome proliferator - activated receptor - gamma in intestinal epithelial cells . - pubmed
Intestinal epithelial cells play an important role in the mucosal immune reaction in inflammatory bowel diseases via the expression of inflammatory mediators , such as cyclooxygenase-2 ( COX-2 ) and intercellular adhesion molecule-1 ( ICAM-1 ) . - pubmed
Collectively , ISL - induced PPARgamma mediated , at least partially , the suppression of intestinal inflammation . - pubmed
EPHA7 and EPHA10 Physically Interact and Differentially Co - localize in Normal Breast and Breast Carcinoma Cell Lines , and the Co - localization Pattern Is Altered in EPHB6 - expressing MDA - MB-231 Cells . - pubmed
SYP-5 , a novel HIF-1 inhibitor , suppresses tumor cells invasion and angiogenesis . - pubmed
The overexpression of HIF-1 induced by hypoxia is closely associated with metastasis , poor prognosis and high mortality . - pubmed
Western blots results showed SYP-5 inhibited hypoxia - induced upregulation of HIF-1 . - pubmed
Furthermore , in the tube formation assay , SYP-5 suppressed angiogenesis induced by hypoxia and VEGF in vitro . - pubmed
Additionally , using Transwell and RTCA assays , we found that SYP-5 also retarded the Hep3B and Bcap37 cells migration and invasion induced by hypoxia and FBS . - pubmed
These results indicates that SYP-5 inhibits tumor cell migration and invasion , as well as tumor angiogenesis , which are mediated by suppressing PI3K / AKT- and MAPK / ERK - dependent HIF-1 pathway . - pubmed
The role of common protective alleles HLA - DRB1 * 13 among systemic autoimmune diseases . - pubmed
Associations between human leukocyte antigen ( HLA ) and susceptibility to systemic autoimmune diseases have been reported . - pubmed
On the other hand , some HLA alleles are associated with resistance to systemic autoimmune diseases , including systemic sclerosis , systemic lupus erythematosus and rheumatoid arthritis . - pubmed
Interestingly , DRB1 * 13 alleles are the protective alleles shared by multiple autoimmune diseases . - pubmed
Thus far , association studies suggested that DRB1 * 13:02 represents at least one of the causally associated protective factors against multiple systemic autoimmune diseases in the Japanese population . - pubmed
DRB1 * 13:02 also confers protection against organ - specific autoimmune diseases and some infectious diseases . - pubmed
Understanding of the protective mechanisms of DRB1 * 13 may lead to the identification of targets for the curative treatment of systemic autoimmune diseases . - pubmed
Analyzing the Effect of V66 M Mutation in BDNF in Causing Mood Disorders : A Computational Approach . - pubmed
A number of preclinical studies emphasize the essential role of brain - derived neurotrophic factor ( BDNF ) in the pathophysiology of mood disorders . - pubmed
IL-33 is associated with a variety of autoimmune diseases , such as sclerosis , inflammatory bowel disease , and rheumatoid arthritis . - pubmed
In this study , we investigated the effects of IL-33 on DC - mediated CD4 + T cell activation and Th17 cell differentiation because DCs are essential cells for presenting self - antigens to CD4 + T cells in autoimmune disease conditions . - pubmed
WWC3 : the bridge linking Hippo and Wnt pathways in lung cancer . - pubmed
When additionally adjusting for total- , LDL- and HDL - cholesterol , triglycerides and C - reactive protein , acyl - alkyl - phosphatidylcholine C36:3 and diacyl - phosphatidylcholines C38:3 and C40:4 remained associated with risk of MI . - pubmed
Therefore , we investigated the roles of AT2R in FGR - induced cardiovascular disease using AT2R knockout ( AT2KO ) mice . - pubmed
AT2R signaling may be involved in cardiovascular disorders of adult offspring with FGR . - pubmed
Regulation of AT2R could contribute to preventing future cardiovascular disease in FGR offspring . - pubmed
SERUM LEVELS OF ENDOTHELIAL MONOCYTE ACTIVATING PEPTIDE II IN TYPE 1 DIABETES . - pubmed
Was investigated serum level of endothelial monocyte activating peptide II ( EMAP - II ) and endothelium - dependent dilatation in type 1 diabetes and possible relation between those . - pubmed
We found an increase serum level of EMAP - II and decrease of endothelium - dependent dilatation in type 1 diabetes . - pubmed
The revealed change of EMAP - II serum level reflects an endothelial dysfunction in type 1 diabetes , alteration of carbohydrate and lipid metabolism could influence of this pathway . - pubmed
Tim-3 exacerbates kidney ischaemia / reperfusion injury through the TLR-4 / NF - kappaB signalling pathway and an NLR - C4 inflammasome activation . - pubmed
In an established murine model of kidney IRI , we found that Tim-3 expression is enhanced on monocytes / macrophages . - pubmed
Anti - Tim-3 antibody RMT3 - 23 ameliorates biochemical and histological kidney injury , reduces apoptosis and decreases macrophage infiltration and cytokine production in ischaemic kidneys . - pubmed
Taken together , our data confirm that Tim-3 signalling enhances injury after kidney IRI and demonstrated that Tim-3 is involved in regulating TLR-4 / NF - kappaB signalling and NLR - C4 inflammasome activation , which provide evidence that Tim-3 signalling is critical for kidney IRI and may provide a new means to ameliorate kidney tissue immune responses in the clinics . - pubmed
Nrf2 as a therapeutic target for rheumatic diseases . - pubmed
Therefore , the appropriate expression and balance of Nrf2 is necessary for regulation of oxidative stress , inflammation , immune responses , and cartilage and bone metabolism . - pubmed
In recent years , novel strategies have been sought to modulate the Nrf2 pathway which has emerged as a therapeutic target in rheumatic conditions . - pubmed
Methods : Circulating EPCs were identified as CD34+CD133+CD31 + cells by flow cytometer in ALC patients ( n = 7 ) and healthy controls ( HC , n = 7 ) . - pubmed
Ex vivo cultures of circulating EPCs from ALC patients ( n = 20 ) and controls ( n = 18 ) were also tested for their functions , including colony formation , LDL uptake , lectin binding and cytokine secretion ( ELISA ) . - pubmed
Increase in CD45hi EPC subtype in ALC patients with enhanced functions , inflammatory cytokines and angiogenic mediators in patients suggests an inflammatory role for these cells in ALC . - pubmed
MicroRNA-28 - 5p inhibits the migration and invasion of gastric cancer cells by suppressing AKT phosphorylation . - pubmed
In conclusion , miR-28 - 5p is a tumor suppressor that inhibits gastric cancer cell migration and invasion through repressing AKT phosphorylation . - pubmed
Activation of trace amine - associated receptor 1 attenuates schedule - induced polydipsia in rats . - pubmed
The present study appears to be the first that estimated the action of TAAR1 agonists on schedule - induced polydipsia , a type of adjunctive behavior , which is considered to be useful for evaluating certain aspects of obsessive - compulsive and related disorders ( OCD ) and schizophrenia . - pubmed
Our results have demonstrated that the wide range of RO5263397 , the highly selective partial TAAR1 agonist , doses ( 1 - 10 mg / kg ) attenuated the polydipsia induced by two different schedules of food delivery in rats . - pubmed
Alterations in KMT2D , CREBBP , or ARID1A or in DNA damage response and repair genes were present at a significantly higher frequency in LS - UTUC . - pubmed
CIC , NOTCH1 , NOTCH3 , RB1 , and CDKN1B alterations were almost exclusive to LS - UTUC . - pubmed
Although FGFR3 mutations were identified in both cohorts , the R248C hotspot mutation was highly enriched in LS - UTUC . - pubmed
LS - UTUC is associated with hypermutation and a significantly higher prevalence of FGFR3 R248C mutation . - pubmed
SP1 induced lncRNA CASC11 accelerates the glioma tumorigenesis through targeting FOXK1 via sponging miR-498 . - pubmed
In vivo and vitro , the knockdown of CASC11 impaired the proliferation , migration and tumor growth of glioma cells . - pubmed
Taken together , the data suggest the regulation of SP1 / CASC11 / miR-498 / FOXK1 in the gliomagenesis , which might provide a potential therapeutic strategy for glioma . - pubmed
Alagille Syndrome : A Novel Mutation in JAG1 Gene . - pubmed
Alagille syndrome is an autosomal dominant multisystem disorder with variable phenotypic penetrance , caused by heterozygous mutations in JAG1 or NOTCH2 , encoding for the components of the Notch signaling pathway . - pubmed
Identification of Aloperine as an anti - apoptotic Bcl2 protein inhibitor in glioma cells . - pubmed
Moreover , western blot and qPCR analysis showed that ALO downregulated Bcl2 expression in human glioma cell lines , SK - N - AS and U118 . - pubmed
In addition , Bcl-2 overexpression could rescue ALO - induced Bcl-2 inhibition and suppress pro - apoptotic effects in glioma cells . - pubmed
Conclusion : Taken together , these findings suggest that the natural agent ALO effectively enhances apoptosis by acting as a potential Bcl2 inhibitor in human glioma cells . - pubmed
The therapeutic potential of PPARs antagonists extends beyond diabetes . - pubmed
PPARs antagonists represent a new drug class that holds promise as a broadly applicable therapeutic approach for cancer treatment . - pubmed
Di ( 2 - ethylhexyl ) phthalate inhibits glutathione regeneration and dehydrogenases of the pentose phosphate pathway on human colon carcinoma cells . - pubmed
OBJECTIVE : Combined methylmalonic acidemia and homocysteinemia is a genetically heterogeneous disorder of cobalamin ( cbl ; vitamin B12 ) metabolism , which consists of five subtypes including cblC , cblD , cblF , cblJ , and cblX deficiencies . - pubmed
Moreover , all patients carried compound heterozygous mutations ( c.80A > G , c.609G > A ) in MMACHC and improved significantly after being treated for cblC deficiency and PAH . - pubmed
In angiogenesis , the expression of CD31 showed a higher percentage of blood vessels in OSCC ( p < 0.001 ) , however , CD34 showed no difference between groups ( p=0.092 ) . - pubmed
OBJECTIVE : Acromegaly is characterized by high neoplastic morbidity as a side effect of growth hormone ( GH ) hypersecretion . - pubmed
Circ - RPL15 / miR-146b-3p / VEGFA feedback loop is responsible for triggering proliferation and migration in glioma . - pubmed
OBJECTIVE : This study aims to elucidate the role of circ - RPL15 in the progression of glioma . - pubmed
PATIENTS AND METHODS : Circ - RPL15 levels in glioma tissues and normal brain tissues were detected . - pubmed
RESULTS : Circ - RPL15 and VEGFA were upregulated in glioma tissues than normal ones , whereas miR-146b-3p was downregulated . - pubmed
The interaction in the circ - RPL15 / miR-146b-3p / VEGFA feedback loop was indicated by Luciferase assay , and it markedly promoted proliferative and migratory abilities in glioma . - pubmed
CONCLUSIONS : Circ - RPL15 triggers proliferative and migratory potentials in glioma by competitively binding miR-146b-3p and thus upregulates VEGFA . - pubmed
Although , these results may be explained partly by the plasma hyperosmolarity and hypernatremia observed in MnPO - lesioned rats ; they also shed light on the role of the MnPO in central neuronal control of renal sodium handling during chronic high dietary salt intake . - pubmed
Estrogen Receptor Beta Inhibits the Proliferation , Migration , and Angiogenesis of Gastric Cancer Cells Through Inhibiting Nuclear Factor - Kappa B Signaling [ Retraction ] . - pubmed
Identification of a novel homozygous variant in the alkaline phosphate ( ALPL ) gene associated with hypophosphatasia . - pubmed
The lack of awareness of patient risk factors , failure to obtain adequate family history , was discussed by clinical experience in prenatal testing of hypophosphatasia with a novel variant in the ALPL gene identified in the index case of the family . - pubmed
Merozoite Surface Protein 2 Adsorbed onto Acetalated Dextran Microparticles for Malaria Vaccination . - pubmed
Merozoite surface protein 2 ( MSP2 ) is a promising vaccine antigen as MSP2 - specific antibodies have been shown previously to be protective against malaria infection . - pubmed
As such , MSP2 adsorbed to Ace - DEX MPs demonstrates promise as a malaria vaccine . - pubmed
Loss of 20q13.13 is characteristic of BIA - ALCL compared with other classes of ALCL , such as primary cutaneous ALCL and systemic type ALK+ and ALK - ALCL . - pubmed
Although this is commonly observed across various types of T - cell lymphomas , the extent of deregulation is significantly higher in BIA - ALCL , as indicated by phosphorylated STAT3 immunohistochemistry . - pubmed
Additionally , co - supplementation significantly decreased fasting glucose ( beta - 7.40 mg / dL ; 95 % CI , - 10.15 , - 4.64 ; P < 0.001 ) , insulin levels ( beta - 1.46 muIU / mL ; 95 % CI , - 2.35 , - 0.57 ; P = 0.002 ) , and homeostasis model of assessment - insulin resistance ( beta - 0.51 ; 95 % CI , - 0.72 , - 0.29 ; P < 0.001 ) and a significant increase in quantitative insulin sensitivity check index ( beta 0.01 ; 95 % CI , 0.006 , 0.01 ; P < 0.001 ) compared with the placebo . - pubmed
sIg+ lymphocytes detected by immunofluorescence and by 51Cr release cytotoxicity showed similar frequency and adherence properties . - pubmed
Lymphocytes bearing major histocompatibility complex ( MHC ) Ia - like antigens shown by eosin exclusion or 51Cr release cytotoxicity were enriched in the adherent fraction , but also occurred in significant numbers in the non - adherent fraction . - pubmed
[ Results of repeated IgE titre determinations for the early diagnosis of tumour recurrence in the otolaryngological area ( author 's transl ) ] . - pubmed
Repeated serum IgE determinations in 292 tumour patients , in parallel with clinical check - ups , show the great diagnostic significance of the serum IgE level . - pubmed
The IgE titre variations give an insight into the tumour - host relationship and , in particular , into the current state of activity of the tumour patients who were found to be tumour - free after specific therapy have constant serum IgE values on repeated examination . - pubmed
Tumour recurrence or metastases cause a sharp increase in the serum IgE level already before clinical manifestations can be ascertained . - pubmed
Intradermal sensitivity test prior to use of streptokinase in acute myocardial infarction . - pubmed
In two of the five intraperitoneal - treated ducks , a reduction in the levels of duck hepatitis B surface antigenaemia ( DHBsAg ) was observed . - pubmed
on the therapeutic level : the attacks resist barbiturate and benzodiazepin treatment in 80 % of the cases , but the attacks diminish as the diabetes is brought under control through insulin treatment . - pubmed
Decreased salivary epidermal growth factor in rheumatoid disease : a possible mechanism for increased susceptibility to gastric ulceration . - pubmed
We have used sequence information from complementary DNA clones , derived from the gene that is deleted in DMD patients , to generate an antiserum that stains the surface membrane of intact human and mouse skeletal muscle , but not that of DMD patients and mdx mice . - pubmed
Using computed tomography , lateral ventricular size was studied in a sample of 112 institutionalized chronic schizophrenic patients ( selected from 510 cases to investigate the correlates of the defect state and intellectual decline and the effects of insulin , electroconvulsive and neuroleptic treatment ) , and compared with matched groups of non - institutionalized schizophrenics , patients with first schizophrenic episodes , institutionalized and non - institutionalized patients with primary affective disorder , and neurotic out - patients . - pubmed
Ventricular enlargement was unrelated to past physical treatment ( neuroleptics , insulin coma and electroconvulsive therapy ) . - pubmed
[ Dosage and duration of the streptokinase treatment in myocardial infarct . - pubmed
Incubation of peritoneal lymphocytes with Corynebacterium parvum and interferon in vitro did not result in augmented cytotoxicity against susceptible targets . - pubmed
Cytokines are known to play a major role in mediating many of the immunological and pathological features of allergic disease . - pubmed
Fifteen patients were hyperthyroid , and 16 were euthyroid but had inhibited secretion of thyrotropin . - pubmed
For hyperthyroid patients , levels of thyroid hormones returned to normal in 69 % after one cycle and in 77 % after two cycles , and levels of thyrotropin returned to normal in 38 % after one cycle and in 69 % after two cycles ; normal levels of thyrotropin were achieved in 93 % of the euthyroid patients after one cycle of treatment and in 100 % of these patients after two cycles . - pubmed
Induction of proliferating cell nuclear antigen in cervical human papilloma virus lesions . - pubmed
The use of a proton pump inhibitor - containing regimen offers the advantage of rapid symptom relief and the highest rates of duodenal ulcer healing . - pubmed
The aim of this study was to characterize the changes in the quantitative expression of beta 2 - integrins and L - selectin detected by means of fluorochrome - conjugated monoclonal antibodies and flow cytometry on leukocytes in the systemic circulation after a major musculoskeletal trauma , i.e. - pubmed
Whole and parotid saliva IgA , IgA1 and IgA2 concentrations have been found to be lower in both HIV infection and AIDS subjects , whereas serum IgA and IgA subclasses are markedly raised , suggesting a dichotomy between systemic and secretory immunity . - pubmed
Antibody responses to oral microbes have also been studied and it has been shown that IgA , IgA1 and IgA2 subclass antibody titres to Candida albicans and to Streptococcus mutans are increased in whole or parotid saliva from HIV patients , but reduced in AIDS patients , suggesting a compensatory response which is overcome with progressive immunodeficiency . - pubmed
The avidity of salivary IgA antibodies to Candida in HIV seems unimpaired , whereas relative avidities of serum antibodies in HIV patients with candidiasis are lowered . - pubmed
The candidacidal , myelomonocytic protein calprotectin is present in saliva at levels which are biologically active , although levels are lowered in HIV infection . - pubmed
Overall , HIV infection appears to be associated with disregulation of a number of immune factors at the mucosal surface , but the ability of patients with HIV infection to mount specific antibody secretory responses seems to be relatively intact until late in infection . - pubmed
Our studies revealed immunoreactivity of IHBs with the monoclonal antibodies SMI 31 and MPM-2 , which recognize hyperphosphorylated epitopes present on paired helical filaments in Alzheimer ' s disease brains ( SMI 31 ) or on diverse proteins hyperphosphorylated by mitotic kinases in the M - phase of the cell cycle ( MPM-2 ) . - pubmed
One- and two - dimensional gel electrophoresis of tumor extracts followed by immunoblotting with SMI 31 and MPM-2 antibodies revealed a major immunoreactive protein with an apparent molecular weight between 62 and 65 kd , which was resolved into several highly acidic ( pH 4.5 ) protein components in two - dimensional gels . - pubmed
IHBs observed in the hepatocellular carcinoma cells presented are the first indications of a role of p62 in disease . - pubmed
The extent of human sodium iodide symporter ( hNIS ) expression in different kinds of human thyroid cancer tissues and cell lines remains controversial . - pubmed
Results showed that 2 of 3 normal tissue , 3 of 6 nodular hyperplasia , one follicular adenoma , 3 of 11 papillary thyroid carcinoma , 1 of 5 follicular carcinoma and none of 3 metastatic thyroid epithelial tissue specimens stained positively for hNIS . - pubmed
In conclusion , although the number of tissue samples examined in this study was small , hNIS staining found a higher ratio of symporter protein expression in normal and benign thyroid tissues compared with malignant tissues . - pubmed
Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation , increased cellularity , and poor prognosis . - pubmed
We have investigated the expression of interleukin-3 receptor alpha ( IL-3Ralpha ) chain in primary blasts from 79 patients with acute myeloid leukemia ( AML ) , 25 patients with B - acute lymphoid leukemia ( B - ALL ) , and 7 patients with T - acute lymphoid leukemia ( T - ALL ) to evaluate a linkage between the expression of this receptor chain , blast proliferative status , and disease prognosis . - pubmed
Although IL-3Ralpha chain was scarcely expressed in most patients with T - ALL , it was overexpressed in 40 % and 45 % of patients with B - ALL and AML , respectively , compared with the levels observed in normal CD34(+ ) progenitors . - pubmed
Second , spontaneous signal transducer and activator of transcription 5 ( Stat5 ) phosphorylation was observed in 13 % of AML patients , all pertaining to the group of patients exhibiting high IL-3Ralpha expression . - pubmed
These findings suggest that in AML , deregulated expression of IL-3Ralpha may contribute to the proliferative advantage of the leukemic blasts and , hence , to a poor prognosis . - pubmed
Fetoplacental leptin levels and their relation to birth weight and insulin in gestational diabetic pregnant women . - pubmed
To investigate the fetoplacental leptin circulation in gestational diabetes , we compared cord leptin and insulin levels in 17 healthy pregnant women and 17 women with gestational - onset diabetes . - pubmed
Similarly , leptin levels in umbilical veins ( mean+/-4.59+/-1.60 ng / ml ) were significantly ( P<0.001 ) higher than those in umbilical arteries ( mean+/-SD 2.08+/-0.90 ng / ml ) in gestational diabetes . - pubmed
However , leptin levels in umbilical veins were significantly higher ( P<0.002 ) in gestational diabetes than those in controls . - pubmed
Additionally , in women with diabetes but not in controls , the birth weight and the cord leptin concentrations were positively related to cord insulin levels . - pubmed
We conclude that there is a hyperleptinaemia in the fetoplacental circulation in pregnant women with carbohydrate intolerance and in these cases insulin and leptin may have antagonist roles regarding fetal development . - pubmed
Human herpesvirus 8 ( HHV-8 ) or Kaposi ' s sarcoma - associated herpesvirus , implicated in the pathogenesis of Kaposi ' s sarcoma , utilizes heparan sulfate - like molecules to bind the target cells via its envelope - associated glycoproteins gB and gpK8.1A. - pubmed
These findings suggest that HHV-8 - gB could mediate cell adhesion via its RGD motif interaction with the cell surface integrin molecules and indicate the induction of cellular signaling pathways , which may play roles in the infection of target cells and in Kaposi ' s sarcoma pathogenesis . - pubmed
RESULTS : Only 3.4 % of CKD patients had their PTH assessed prior to RRT , and 0.3 % had vitamin D status measured . - pubmed
HBcAg concentrations correlated very closely with HBV DNA ( r = 0.946 , n = 145 ) in 216 samples from 72 hepatitis B patients . - pubmed
Expression profiling identified processes likely responsible for 18 - fluoro-2 - deoxy - glucose uptake and tumor localization by positron emission tomography , and a role for hypoxia - inducible factor-1 was suggested . - pubmed
Potentially important up - regulated genes included gp96 , lung resistance - related protein , galectin-3 binding protein , the M(r ) 67,000 laminin receptor ( on tumor vessels ) , and voltage - dependent anion channels . - pubmed
Obesity raises blood pressure by increasing renal tubular reabsorption , impairing pressure natriuresis , causing volume expansion due to activation of the sympathetic nervous system and renin - angiotensin system , and by physical compression of the kidneys , especially when visceral obesity is present . - pubmed
[ HAPTOGLOBINS AND BLOOD GROUPS IN FAMILIAL MULTIPLE SCLEROSIS ] . - pubmed
A STUDY OF BLEACHING OF THE FUNDUS OCULI IN PIGMENTARY DEGENERATIONS OF THE RETINA . - pubmed
[ ON THE EFFECT OF THE ENZYME INHIBITOR TRASYLOL IN THE THERAPY AND PROPHYLAXIS OF ACUTE PANCREATITIS : REPORT BASED ON 893 CASES ] . - pubmed
METHODS : The inhibition of tyrosine kinase may represent a novel approach in the treatment of spinal cord ischemia reperfusion injury . - pubmed
Recently , a family of tyrosine kinase inhibitors , the tyrphostins , has been successfully used in models of endotoxemia , peritonitis , and hypovolemic shock . - pubmed
CONCLUSIONS : Tyrphostin Ag 556 alters spinal cord ischemia reperfusion injury by inhibiting protein kinases . - pubmed
Adenoviral ( Ad ) vectors were produced to overexpress EGFRvIII in vitro or in xenograft tumors in vivo . - pubmed
RESULTS : The presence of EGFRvIII was verified in all xenograft tumors tested with no detectable expression in the corresponding cells under in vitro culture conditions . - pubmed
MDA - MB-231 xenograft tumors demonstrated EGFRvIII expression levels , which were 1.9 - fold higher relative to EGFRwt compared to a 14.5 - fold higher Tyr - P. Ionizing radiation of these tumors at 4 Gy induced an average 3.2 - fold increase in EGFRvIII Tyr - P. EGFRvIII expression in U-373 MG cells significantly enhanced survival after 4Gy , which was completely abolished by dominant - negative EGFR - CD533 . - pubmed
Finally , the ability of EGFRvIII to accelerate tumor growth during irradiation was confirmed in vivo . - pubmed
CONCLUSION : EGFRvIII is frequently expressed in a variety of different tumor types and can confer significant radioresistance , thus further providing evidence for EGFRvIII as an additional important target in our approaches to radiosensitize malignant solid tumors . - pubmed
Burkholderia cenocepacia H111 , which was isolated from a cystic fibrosis patient , employs a quorum - sensing ( QS ) system , encoded by cep , to control the expression of virulence factors as well as the formation of biofilms . - pubmed
Thus , AidA appears to be required for establishing an infection - like process rather than acting as a toxin . - pubmed
BACKGROUND : To assess the role of alkaline phosphatase ( AP ) , gamil - glutamyltransferase ( gammaGT ) and abdominal ultrasound ( US ) as predictors of choledocholithiasis in patients sustaining acute biliary pancreatitis . - pubmed
Naive CD4(+ ) T cells in RA are contracted in diversity and restricted in clonal burst . - pubmed
We conducted a multicenter phase II study to evaluate the efficacy and tolerability of the docetaxel plus epirubicin combination chemotherapy as first - line treatment in MBC and performed a prospective assessment of the predictive values of circulating HER2 extracellular domain ( ECD ) and vascular endothelial growth factor ( VEGF ) . - pubmed
We concluded that the docetaxel and epirubicin combination is an effective first - line treatment in MBC patients and that elevated serum HER2 ECD levels , but not circulating VEGF levels , predict a poor outcome . - pubmed
OBJECTIVE : A recent single - center multivariate analysis of hepatitis C ( HCV ) patients showed that having any two criteria : 1 ) ferritin & gt ; or = 200 microg / l and 2 ) spider nevi and/or albumin & lt ; or = 35 g / l predicted grade 2 or greater histological inflammation ; the presence of any two of the following criteria : spider nevi , platelets & lt ; or = 150 x 109 / l , palpable splenomegaly and/or albumin & lt ; or = 35 g / l predicted stage 2 or greater histological fibrosis . - pubmed
Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice : central role of epithelial - derived MMP . - pubmed
BACKGROUND & amp ; AIMS : There is mounting evidence that matrix metalloproteinases are the predominant proteinases expressed in the gut mucosa during active inflammatory bowel disease . - pubmed
We investigated the role of metalloproteinase 9 ( MMP-9 ) , a secreted gelatinase that is consistently up - regulated in both animal models and human inflammatory bowel disease and is associated with disease severity , in the pathogenesis of colitis by using mice containing a targeted deletion of the MMP-9 gene . - pubmed
RESULTS : MMP-9 activity and protein expression were absent from normal colonic mucosa but were up - regulated during experimental colitis . - pubmed
MMP-9-/- mice exposed to dextran sodium sulfate or salmonella had a significantly reduced extent and severity of colitis . - pubmed
Immunohistochemical studies showed that MMP-9 was localized to epithelial cells and granulocytes during active colitis . - pubmed
Neutrophil transmigration studies and bone marrow chimeras showed that neutrophil MMP-9 is neither required for its migration nor sufficient to induce tissue damage during colitis and that epithelial MMP-9 is important for tissue damage . - pubmed
MMP-9 inhibited cell attachment and wound healing in the model intestinal epithelial cell line , Caco2 - BBE . - pubmed
CONCLUSIONS : Taken together , our data suggest that MMP-9 expressed by epithelial cells may play an important role in the development of colitis by modulating cell - matrix interaction and wound healing . - pubmed
Purification and characterization of human kallikrein 11 , a candidate prostate and ovarian cancer biomarker , from seminal plasma . - pubmed
PURPOSE : Preliminary data suggest that hK11 is a novel serum biomarker for prostate and ovarian cancer . - pubmed
Empiric treatments include the use of calcium channel blockers , steroids , induced hypertension or blood pressure lowering , and rarely endovascular therapy . - pubmed
Activity of PXD101 , a histone deacetylase inhibitor , in preclinical ovarian cancer studies . - pubmed
In the current investigation , we examined the activity of PXD101 , a potent histone deacetylase inhibitor , used alone or in combination with clinically relevant chemotherapeutics ( docetaxel , paclitaxel , and carboplatin ) , in preclinical in vitro and in vivo models of ovarian cancer . - pubmed
Shrimp ( Penaeus monodon ) anti - lipopolysaccharide factor reduces the lethality of Pseudomonas aeruginosa sepsis in mice . - pubmed
Due to its multifunctional properties , the SALF(55 - 76 ) cyclic peptide may become an important prophylaxis against and therapy for bacterial infectious diseases , as well as for septic shock . - pubmed
Despite this heterogeneity , up to 50 % of prelingual recessive non - syndromic deafness can be attributed to mutations in the GJB2 gene ( Connexin-26 , gap - junction protein ) . - pubmed
Activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats with dopamine deficiency - dependent MPTP - induced depressive syndrome . - pubmed
The development of MPTP - induced depressive syndrome in rats was accompanied by activation of prolyl endopeptidase and dipeptidyl peptidase IV in the brain frontal cortex . - pubmed
OBJECTIVE : Limited data on patients undergoing Roux - en - Y gastric bypass surgery ( RY - GBP ) suggest that an improvement in insulin secretion after surgery occurs rapidly and thus may not be wholly accounted for by weight loss . - pubmed
RESEARCH DESIGN AND METHODS : Incretin ( gastric inhibitory peptide [ GIP ] and glucagon - like peptide-1 [ GLP-1 ] ) levels and their effect on insulin secretion were measured before and 1 month after RY - GBP in eight obese women with type 2 diabetes and in seven obese nondiabetic control subjects . - pubmed
RESULTS : Fasting and stimulated levels of GLP-1 and GIP were not different between control subjects and patients with type 2 diabetes before the surgery . - pubmed
Wnt signaling in polycystic kidney disease . - pubmed
Some polycystic kidney disease proteins , such as Inversin and Bardet - Biedl syndrome family members , were found to use components of the Wnt signaling cascade to orient cells along a secondary polarity axis within the plane of the epithelium . - pubmed
Expression of oncofetal fibronectin mRNA in thyroid anaplastic carcinoma . - pubmed
BACKGROUND : Oncofetal fibronectin ( onfFN ) is a fetal protein , the expression of which is observed in papillary thyroid carcinomas but not in follicular tumors or in normal thyroid . - pubmed
METHODS : We examined the expression levels of onfFN mRNA in ATC tissues and cell lines derived from ATC by real - time quantitative reverse transcription - polymerase chain reaction ( PCR ) and in situ hybridization . - pubmed
RESULTS : Increased expression of onfFN mRNA was observed in all cases of ATC regardless of the type of accompanying differentiated carcinoma and five of six ATC cell lines . - pubmed
Furthermore , expression of onfFN mRNA was observed in the majority of ATC cells in all six tissues examined by in situ hybridization . - pubmed
CONCLUSION : These results confirm that expression of onfFN mRNA characterizes not only papillary thyroid carcinoma but also ATC . - pubmed
onfFN mRNA or protein may be a useful marker to identify anaplastic carcinoma cells and may be considered as an optimistic target in molecular - based therapy of ATC . - pubmed
Treatment of biochemical recurrence of prostate cancer with granulocyte - macrophage colony - stimulating factor secreting , allogeneic , cellular immunotherapy . - pubmed
MATERIALS AND METHODS : Patients with noncastrate prostate cancer ( 19 ) with biochemical ( prostate specific antigen ) recurrence following prostatectomy or radiation therapy and no radiological evidence of metastasis were enrolled in the study . - pubmed
CONCLUSIONS : Granulocyte - macrophage colony - stimulating factor secreting cellular immunotherapy has a favorable toxicity profile with signals of clinical and immunological activity against hormone naive prostate cancer . - pubmed
( 2008 ) Two single nucleotide polymorphisms identify the highest - risk diabetes HLA genotype : Diabetes 57:3152 - 3155 , 2008 . - pubmed
Interaction between renin - angiotensin and sympathetic nervous systems in a rat model of pressure overload cardiac hypertrophy . - pubmed
A large fraction of this resides in the DCT , namely , ( i ) the transient receptor potential channel melastatin subtype 6 ( TRPM6 ) , a divalent cation - permeable channel located at the luminal membrane of the DCT , facilitates Mg ( 2 + ) entry from the pro - urine into the cell ; ( ii ) the epidermal growth factor is a novel hormone regulating active Mg ( 2 + ) transport through TRPM6 ; ( iii ) the voltage - gated K (+ ) channel , Kv1.1 , establishes a favorable luminal membrane potential for TRPM6 - mediated Mg ( 2 + ) transport ; ( iv ) the Na (+)/ K (+)- ATPase gamma - subunit ( gamma - Na (+)/ K (+)- ATPase ) was identified as mutated protein in a family with isolated dominant hypomagnesemia . - pubmed
The molecular mechanism by which gamma - Na (+)/ K (+)- ATPase is involved in DCT Mg ( 2 + ) handling remains unknown ; ( v ) a high percentage of patients with mutations in the renal transcription factor HNF1B ( hepatocyte nuclear factor 1 homeobox B ) gene develop hypomagnesemia ; and ( vi ) Gitelman and EAST / SeSAME syndrome patients suffer from a similar tubulopathy due to mutations in NCC ( NaCl cotransporter ) and Kir4.1 , respectively . - pubmed
In these patients , decreased expression of TRPM6 is proposed to cause hypomagnesemia . - pubmed
Concentrations of von Willebrand factor ( vWF ) and factor VIII are lower in individuals with blood group 0 compared to subjects with blood group A , B or AB , which might in turn result in a reduced inhibition of platelet aggregation in individuals with blood group 0 . - pubmed
Association between FokI polymorphism in vitamin D receptor gene and susceptibility to spinal tuberculosis in Chinese Han population . - pubmed
BACKGROUND AND AIMS : Studies have shown that the vitamin D receptor ( VDR ) gene polymorphisms may be associated with pulmonary tuberculosis ( TB ) and play important roles in the regulation of calcium in a variety of tissues including bone . - pubmed
To our knowledge , however , whether FokI polymorphism in VDR gene is associated with susceptibility to spinal TB is still unknown . - pubmed
We undertook this study to investigate the association between FokI polymorphism in VDR gene and susceptibility to spinal TB in Chinese Han population . - pubmed
FokI polymorphism in VDR gene was analyzed by polymerase chain reaction - restriction fragment length polymorphism ( PCR - RFLP ) in the spinal TB group and the control group . - pubmed
CONCLUSIONS : FokI polymorphism in VDR gene may be associated with the susceptibility to spinal TB in Chinese Han population . - pubmed
The significance of strong histone deacetylase 1 expression in the progression of prostate cancer . - pubmed
AIMS : Histone deacetylases ( HDACs ) play important roles in many types of cancer . - pubmed
Recently , it has been reported that HDAC1 expression in prostate cancer is significantly higher than in benign prostate cell lines and tissues . - pubmed
The expression of HDAC1 in association with the clinicopathological data was investigated to define its functional and pathological roles in prostate cancer . - pubmed
METHODS AND RESULTS : HDAC1 expression was examined immunohistochemically in 148 patients with prostate cancer . - pubmed
Strong expression of HDAC1 in benign prostate glands , high - grade prostatic intraepithelial neoplasia ( PIN ) and prostate cancer was observed in 17/148 ( 11 % ) , 19/71 ( 27 % ) and 69/148 ( 47 % ) patients . - pubmed
CONCLUSIONS : These results indicate that overexpression of HDAC1 contributes to progression and poor prognosis in prostate cancer . - pubmed
Cd treatments led to a decline in mycorrhizal infection ( MI ) , nodule number and dry weights which was accompanied by reductions in leghemoglobin content , nitrogenase activity , organic acid contents . - pubmed
Although there is little evidence that PMT might have a role in human cancer , it serves as an important and novel paradigm for a bacterial link to cancer . - pubmed
Polyneuropathy , organomegaly , endocrinopathy , M - protein , and skin changes ( POEMS ) syndrome is a multisystem disorder associated with plasma cell dyscrasia . - pubmed
Elevated serum levels of vascular endothelial growth factor ( VEGF ) , which strongly promotes neovascularization and vasopermeability , are considered to be responsible for the characteristic symptoms such as angiomata , pleural effusion / ascites , edema , and organomegaly in the disorder . - pubmed
To study whether other angiogenetic factors are upregulated in POEMS syndrome , we measured serum levels of basic fibroblast growth factor and hepatocyte growth factor ( HGF ) , as well as VEGF , in 17 patients with POEMS syndrome . - pubmed
These results suggest that different angiogenetic factors might contribute to the pathogenesis of POEMS syndrome , and this fact might contribute to the insufficient clinical effects obtained by suppression of VEGF alone . - pubmed
HSR also resulted in prominent histopathological damage , including congestion , edema , cellular infiltration and hemorrhage . - pubmed
The protective effects of CO against lung injury were notably associated with an increase in the protein expression level of peroxisome proliferator - activated receptor ( PPAR )- gamma , an anti - inflammatory transcriptional regulator in the lung . - pubmed
These findings suggest that inhalation of CO at a low concentration exerts a potent therapeutic effect against HSR - induced ALI and attenuates the inflammatory cascade by increasing PPAR - gamma protein expression . - pubmed
The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations . - pubmed
Activation of the transcription factor STAT5 is essential for the pathogenesis of acute myelogenous leukemia ( AML ) containing the FLT3 internal tandem duplication ( ITD ) mutation . - pubmed
FLT3 ITD is a constitutively active tyrosine kinase that drives the activation of STAT5 , leading to the growth and survival of AML cells . - pubmed
Pimozide inhibits the tyrosine phosphorylation of STAT5 , leading to the death of AML cells through the induction of apoptosis . - pubmed
Significantly , pimozide reduces the tumor burden in a mouse model of FLT3 - driven AML . - pubmed
Therefore , identifying STAT5 inhibitors may provide a new avenue for the treatment of AML , and these may be effective alone or in combination with tyrosine kinase inhibitors . - pubmed
The HSP90 inhibitor NVP - AUY922 - AG inhibits the PI3 K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells . - pubmed
HSP90 inhibition potentially facilitates the simultaneous targeting of multiple molecules within tumour cells and represents an attractive therapeutic proposition . - pubmed
Here , we investigated HSP90 as a molecular target for acute myeloid leukaemia ( AML ) using the novel HSP90 inhibitor NVP - AUY922 - AG . - pubmed
This study shows that the novel HSP90 inhibitor NVP - AUY922 - AG has significant single agent activity in AML cells and is synergistic with Ara - C. - pubmed
Scleredema is a form of cutaneous mucinosis caused by an increased accumulation of collagen and mucin in the dermis . - pubmed
[ Block effects of BDNF antibody on MEK expression in lung of rats with brain ischemia ] . - pubmed
UNLABELLED : OBJECITVE : To explore the block effect of brain - derived neurotrophic factor ( BDNF ) antibody on the mitogen extracellular kinase ( MEK ) expression in lung tissues of rats with brain ischemia . - pubmed
METHODS : Adult SD rats were divided into sham group , brain ischemia lung injury ( BILI ) group , and BDNF antibody treated group . - pubmed
RT - PCR showed that BDNF antibody block significantly decreased the expressional level of MEK mRNA in the lung tissues with brain ischemia ( P<0.05 ) . - pubmed
CONCLUSION : BDNF antibody block leads to a significant reduction of MEK expression in endothelia cells of lung tissue in the rats with brain ischemia . - pubmed
Every quarter , mean levels and prevalence of conformity were collected for the following indicators : anemia , dialysis dose , serum calcium and phosphorus , PTH , 25OH - vitamin D , albumin , serum bicarbonate , LDL - cholesterol , serum beta2 - microglobulin , systolic and diastolic blood pressure , intradialytic hypotension and vascular access . - pubmed
Finally , we suggest that the definition and targets of some indicators , especially hypertension and LDL - cholesterol , be reviewed , since evidence of their association with mortality is not demonstrated . - pubmed
Initial investigations revealed atrial fibrillation ( AF ) and pericardial effusion , further investigations unraveled primary hypothyroidism ( thyroid stimulating hormone ) of 34.7 muIU / ml and total thyroxine ( T4 ) of 5.57 mug / dl ) . - pubmed
Eight months after the start of chemotherapy , 9 courses had been administered , the carcinoembryonic antigen ( CEA)/carbohydrate antigen ( CA ) 19 - 9 level had decreased to the reference value , and the decrease in size of the liver metastases indicated a partial response ( PR ) , as assessed by CT . - pubmed
Microbial heat shock proteins ( HSP ) play an important role of in the pathogenesis of autoimmune diseases because of the high level of sequence homology with human HSP . - pubmed
RATIONALE : Post - intravenous recombinant tissue plasminogen activator ( r - tPA ) orolingual angioedema ( PIROLA ) , including the life - threatening form , is an underappreciated complication of ischaemic stroke treatment . - pubmed
RESULTS : Of the 129 acute ischaemic stroke patients treated at Bourg - en - Bresse between 2010 and 2012 , four patients , all receiving angiotensin converting enzyme inhibitor ( ACEI ) , developed a PIROLA ( cumulative incidence rate : 32 % ) . - pubmed
Association between single nucleotide polymorphisms of asporin ( ASPN ) and BMP5 with the risk of knee osteoarthritis in a Chinese Han population . - pubmed
The aim of this study was to investigate associations between single nucleotide polymorphisms rs13301537 in asporin ( ASPN ) and rs373444 in the bone morphogenetic protein 5 ( BMP5 ) gene with knee osteoarthritis ( OA ) susceptibility in a Chinese Han population . - pubmed
ASPN rs13301537 and BMP5 rs373444 polymorphisms were genotyped in patients with knee OA and age- and sex - matched OA - free controls from a Chinese Han population . - pubmed
In contrast , the CT and CC genotypes of rs373444 in BMP5 were not significantly associated with the risk of knee OA , even after further stratification analysis according to age or sex . - pubmed
Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population . - pubmed
However , there is no available information on whether alpha - PA affects gene expression in leukemia cells . - pubmed
Effect of caffeine and adenosine receptor ligands on the expression of spike - and - wave discharges in Genetic Absence Epilepsy Rats from Strasbourg ( GAERS ) . - pubmed
Autocrine human growth hormone stimulates the tumor initiating capacity and metastasis of estrogen receptor - negative mammary carcinoma cells . - pubmed
We demonstrated herein that autocrine hGH promoted cancer stem cell ( CSC)-like properties of estrogen receptor - negative mammary carcinoma ( ER - MC ) cells in vitro . - pubmed
In xenograft studies , autocrine hGH increased the tumor initiating capacity of ER - MC cells . - pubmed
Thus , inhibition of hGH is a potential therapeutic strategy to prevent tumor initiation and metastasis of ER - MC . - pubmed
The antitumor immune response generated by fractionated radiation therapy may be limited by tumor cell adaptive resistance and can be circumvented by PD - L1 blockade . - pubmed
We demonstrated that fractionated RT led to increased tumor cell expression of programmed cell death ligand 1 ( PD - L1 ) in response to CD8 + T cell production of interferon gamma . - pubmed
Increased circulating interleukin-17 levels in preeclampsia . - pubmed
We determined circulating levels of interleukin-17 ( IL-17 ) along with those of angiogenic factors in healthy nonpregnant and pregnant women and preeclamptic patients , and examined whether serum IL-17 levels of preeclamptic patients were related to their clinical features and angiogenic factor concentrations . - pubmed
We did not find any relationship between serum IL-17 concentrations of preeclamptic patients and their clinical features and serum sFlt-1 and PlGF levels or sFlt-1 / PlGF ratios . - pubmed
However , elevated serum IL-17 level and sFlt-1 / PlGF ratio were found to have an additive effect on the risk of preeclampsia , as shown by the substantially higher odds ratios of a combination of the two than of either alone . - pubmed
In conclusion , serum IL-17 levels are increased in preeclampsia , which may contribute to the development of the excessive systemic inflammatory response characteristic of the maternal syndrome of the disease . - pubmed
In addition , elevated serum IL-17 level and sFlt-1 / PlGF ratio had an additive ( joint ) effect on the risk of preeclampsia . - pubmed
The transcription factor Nrf2 - mediated antioxidant response represents a critical cellular defense mechanism ; however , emerging data suggest that constitutive activation of Nrf2 is associated with cancer development and chemotherapy resistance . - pubmed
The reasons Nrf2 continuously accumulates in cancer cells remain to be fully understood . - pubmed
Mediobasal hypothalamic overexpression of DEPTOR protects against high - fat diet - induced obesity . - pubmed
RESULTS : We first report that systemic ( brain and periphery ) overexpression of DEPTOR prevents high - fat diet - induced obesity , improves glucose metabolism and protects against hepatic steatosis . - pubmed
AIM : A high level of matrix metalloproteinase 9 ( MMP-9 ) is a predictor of poor wound healing in diabetic foot ulcers . - pubmed
Here , we aimed to explore the changes of alpha - KG and its relationship with MMP-9 and TET2 during diabetic wound healing . - pubmed
RESULTS : The levels of alpha - KG , TET2 and MMP-9 were significantly increased in diabetic wound compared with nondiabetic wound ( P = 0 010 , 0 016 and 0 025 ) . - pubmed
CONCLUSIONS : The levels of alpha - KG , TET2 and MMP-9 were significantly increased in diabetic wound compared with nondiabetic wound . - pubmed
Immunohistochemistry of AVN preparations revealed increased fibrosis and gap junction protein ( connexin43 and 40 ) remodelling in the AVN of LVD animals compared to sham . - pubmed
High Risk HPV E6 / E7 Oncoprotein Expression in Women with High Grade Squamous Intraepithelial Lesion . - pubmed
PURPOSE : To correlate the expression of high - risk HPV E6 mRNA with pap smear , colposcopy , and biopsy results in women with high grade squamous intraepithelial lesion ( HSIL ) . - pubmed
Pap smear tests revealed that the E6 / E7 test was positive in 107 ( 83.8 % ) women with atypical squamous cells - high grade ( ASC - H ) , HSIL , or higher . - pubmed
When analyzing the association with colposcopy results , the frequency of positive E6 / E7 results increased with the severity of the injury , ranging from 57.1 % in women without colposcopy - detected injury to 86.5 % in those with higher levels of colposcopy findings . - pubmed
Of the 111 women who underwent biopsy and E6 / E7 testing , the E6 / E7 test was positive in 84.7 % of the women who presented with lesions of cervical intraepithelial neoplasia ( CIN ) grade 2 or higher . - pubmed
CONCLUSIONS : E6 / E7 mRNA expression was higher in women with HSIL and CIN grade 2 or higher . - pubmed
JNK Activation Contributes to Oxidative Stress - Induced Parthanatos in Glioma Cells via Increase of Intracellular ROS Production . - pubmed
In this study , we used glioma cell lines and H2O2 to investigate the role of JNK in glioma cell parthanatos induced by oxidative stress . - pubmed
We found that exposure to H2O2 not only induced intracellular accumulation of ROS but also resulted in glioma cell death in a concentration- and incubation time - dependent manner , which was accompanied with cytoplasmic formation of PAR polymer , expressional upregulation of PARP-1 , mitochondrial depolarization , and AIF translocation to nucleus . - pubmed
Pharmacological inhibition of PARP-1 with 3AB or genetic knockdown of its level with siRNA rescued glioma cell death , as well as suppressed cytoplasmic accumulation of PAR polymer and nuclear translocation of AIF , which were consistent with the definition of parthanatos . - pubmed
Either attenuation of intracellular ROS with antioxidant NAC or inhibition of JNK phosphorylation with SP600125 or JNK siRNA could significantly prevent H2O2 - induced parthanatos in glioma cells . - pubmed
Thus , we demonstrated that JNK activation contributes to glioma cell parthanatos caused by oxidative stress via increase of intracellular ROS generation . - pubmed
Immunotherapy of non - Hodgkin ' s lymphoma with a defined ratio of CD8 + and CD4 + CD19 - specific chimeric antigen receptor - modified T cells . - pubmed
CD19 - specific chimeric antigen receptor ( CAR)-modified T cells have antitumor activity in B cell malignancies , but factors that affect toxicity and efficacy have been difficult to define because of differences in lymphodepletion and heterogeneity of CAR - T cells administered to individual patients . - pubmed
We conducted a clinical trial in which CD19 CAR - T cells were manufactured from defined T cell subsets and administered in a 1:1 CD4(+)/CD8(+ ) ratio of CAR - T cells to 32 adults with relapsed and/or refractory B cell non - Hodgkin ' s lymphoma after cyclophosphamide ( Cy)-based lymphodepletion chemotherapy with or without fludarabine ( Flu ) . - pubmed
Astragaloside IV protects against podocyte injury via SERCA2 - dependent ER stress reduction and AMPKalpha - regulated autophagy induction in streptozotocin - induced diabetic nephropathy . - pubmed
Moreover , diabetes or HG - induced podocyte apoptosis was markedly attenuated by AS - IV , paralleled by a marked remission in ER stress and a remarkable restoration in impaired autophagy , which were associated with a significant improvement in the expression of sarcoendoplasmic reticulum Ca2 + ATPase 2b ( SERCA2b ) and AMP - activated protein kinase alpha ( AMPKalpha ) phosphorylation , respectively . - pubmed
Collectively , these results suggest that AS - IV prevented the progression of DN , which is mediated at least in part by SERCA2 - dependent ER stress attenuation and AMPKalpha - promoted autophagy induction . - pubmed
Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity : a pilot study . - pubmed
NP cells robustly expressed isoforms CA9 / 12 , which were hypoxia - inducible . - pubmed
In addition to increased mRNA stability under hypoxia , we observed binding of HIF-1alpha to select hypoxia - responsive elements on CA9/12 promoters using genomic chromatin immunoprecipitation . - pubmed
Taken together , our studies show for the first time that bicarbonate buffering through the HIF-1alpha - CA axis is critical for NP cell survival in the hypoxic niche of the intervertebral disc . - pubmed
Particularly , anticardiolipin antibodies , anti - beta2 - glycoprotein I antibodies and lupus anticoagulant are essential tools for APS diagnosis . - pubmed
Germline pathogenic variants in ALK and PHOX2B , as well as other cancer predisposition genes , are increasingly implicated in the pathogenesis of neuroblastic tumors . - pubmed
The algorithm correctly identified all six children ( Beckwith - Wiedemann ( n = 2 ) , Fanconi anemia , RB1 , PHOX2B , chromosome duplication involving ALK ) as requiring a genetic evaluation by using clinical features present at diagnosis . - pubmed
RESULTS : Mean Hb concentration was similar ( 11.0 vs 11.0 g / dL ) in patients treated in both countries and the proportion of patients within KDIGO anemia target was 69.5 % in Poland vs 65.8 % in Portugal ( NS ) . - pubmed
Correction to : Unexpected Benefit from Alpelisib and Fulvestrant in a Woman with Highly Pre - treated ER - Positive , HER2 - Negative PIK3CA Mutant Metastatic Breast Cancer . - pubmed
[ Effect of Scalp Penetration Acupuncture on the Expression of NGF in Brain Tissue around Hematoma of Intracerebral Hemorrhage Rats ] . - pubmed
Objective To observe the effects of scalp penetration acupuncture on the expression of nerve growth factor ( NGF ) in brain tissue around hematoma of intracerebral hemorrhage rats . - pubmed
The expression of NGF positive cells in brain tissue around hematoma was detected using immunohistochemical method . - pubmed
Immunohistochemistry with a pan - TRK antibody distinguishes secretory carcinoma of the salivary gland from acinic cell carcinoma . - pubmed
AIMS : Secretory carcinoma ( previously known as mammary analogue secretory carcinoma ) is characterised by ETV6 rearrangements , most often ETV6 - NTRK3 fusion . - pubmed
A recently developed pan - TRK antibody shows promise for identifying tumours with NTRK fusions . - pubmed
The aim of this study was to evaluate the utility of pan - TRK immunohistochemistry in distinguishing secretory carcinoma from mimics . - pubmed
METHODS AND RESULTS : We examined whole - tissue sections from 86 tumours , including 14 secretory carcinomas ( 12 parotid primaries and one buccal primary , and one metastasis ; five with ETV6 rearrangement confirmed by fluorescence in - situ hybridisation , and one with ETV6 - NTRK3 fusion and one with ETV6 - RET fusion detected by targeted sequencing ) , 14 acinic cell carcinomas , 18 polymorphous adenocarcinomas , 20 low - grade mucoepidermoid carcinomas , and 20 pleomorphic adenomas . - pubmed
Pan - TRK staining was detected in nine ( 64 % ) secretory carcinomas , all with a nuclear pattern and four with diffuse staining ( & gt;50 % of cells ) . - pubmed
Among other tumour types , pan - TRK immunoreactivity was observed in all ( 100 % ) pleomorphic adenomas ( particularly myoepithelial cell - rich , myxoid areas ) , 15 ( 83 % ) polymorphous adenocarcinomas , and four ( 20 % ) low - grade mucoepidermoid carcinomas , all with predominantly membranous / cytoplasmic immunoreactivity ; only six cases showed focal ( & lt;10 % ) nuclear staining . - pubmed
CONCLUSIONS : Although pan - TRK expression is not entirely sensitive or specific for secretory carcinoma , nuclear staining distinguishes secretory carcinoma from mimics . - pubmed
Acinic cell carcinomas are negative for pan - TRK , though membranous expression of TRK is common in other salivary gland neoplasms . - pubmed
The lack of pan - TRK immunoreactivity in a subset of secretory carcinomas may suggest non - NTRK fusion partners . - pubmed
Supplementation with whole garlic attenuated HFD - enhanced ratio of serum GPT / GOT ( glutamic - pyruvic transaminase / glutamic - oxaloacetic transaminase ) , levels of T - Cho ( total cholesterol ) and LDLs ( low - density lipoproteins ) , and index of homeostatic model assessment for insulin resistance ( HOMA - IR ) , but had no significant effect in the levels of serum HDL - c ( high density lipoprotein cholesterol ) , TG ( total triacylglycerol ) , and glucose . - pubmed
Biomarker discovery applied to myalgic encephalomyelitis / chronic fatigue syndrome ( ME / CFS ) , a disabling disease of inconclusive aetiology , has identified several cytokines to potentially fulfil a role as a quantitative blood / serum marker for laboratory diagnosis , with activin B a recent addition . - pubmed
Previous pilot study results showed that activin B was significantly elevated for the ME / CFS participants compared to healthy ( control ) participants . - pubmed
A significant difference for serum activin B was also detected for ME / CFS and control cohorts recruited for this study , but median levels were significantly lower for the ME / CFS cohort . - pubmed
A closer analysis revealed that the inclusion of activin B to the panel of pathology markers improved the prediction of mild to moderate ME / CFS cases . - pubmed
OBJECTIVE : The elevated expression of phospholamban ( PLB ) has been observed in heart failure and cardiac remodeling , inhibiting the affinity of Ca2 + pump to Ca2 + thereby impairing heart relaxation . - pubmed
METHODS AND RESULTS : A mouse model specifically deleted HuR in cardiomyocytes were used for testing the role of HuR in regulating PLB during isoproterenol ( ISO)-induced cardiac remodeling . - pubmed
However , deletion of HuR in cardiomyocytes mitigated the effect of ISO in inducing PLB expression and reducing beta1 - AR expression , in turn aggravating ISO - induced myocardial hypertrophy and cardiac fibrosis . - pubmed
Role of JNK Signaling Pathway in Dexmedetomidine Post - Conditioning - Induced Reduction of the Inflammatory Response and Autophagy Effect of Focal Cerebral Ischemia Reperfusion Injury in Rats . - pubmed
The escape latency ( EL ) ; cerebral infarction area ratio ; positive apoptosis ; neuron pathological changes ; auto - phagosome numbers ; inflammatory factor contents ; mRNA and protein expressions of Beclin-1 , Caspase-3 and LC3II / I ; and the phosphorylation level of JNK were decreased , while the times across platform and the times stayed in the quadrant of the original platform were increased after dexmedetomidine treatment . - pubmed
However , the protective effect of dexmedetomidine on brain injury in MCAO rats was reversed by JNK pathway activator . - pubmed
Decreased H3K9 acetylation level of LXRalpha mediated dexamethasone - induced placental cholesterol transport dysfunction . - pubmed
Atopic inflammation is complex largely due to the various cytokines which affect eosinophil activation , proliferation , differentiation , and survival . - pubmed
Pathogenic variants in NUBPL result in failure to assemble the matrix arm of complex I and cause a complex leukoencephalopathy with thalamic involvement . - pubmed
Recently , genetic changes in the complex I assembly factor NUBPL have been characterized by a consistent recognizable pattern of leukoencephalopathy affecting deep white matter including the corpus callosum and cerebellum . - pubmed
Compromised NUBPL activity impairs assembly of the matrix arm of complex I and produces a severe , rapidly - progressive leukoencephalopathy with thalamic involvement on MRI , further expanding the neuroimaging phenotype . - pubmed
Here , we discovered that PDDOL , a natural variation allele of PLEIOTROPIC DEVELOPMENTAL DEFECTS ( PDD ) , leads to pleiotropic developmental defects in a near - isogenic line generated by introgressing the wild rice Oryza longistaminata into the rice ( Oryza sativa ) cultivar 187R. - pubmed
beta - Thalassemia is an inherited single gene disorder related to reduced synthesis of the beta - globin chain of hemoglobin . - pubmed
Effects of Reduced Connexin43 Function on Mandibular Morphology and Osteogenesis in Mutant Mouse Models of Oculodentodigital Dysplasia . - pubmed
Mutations in the gene encoding the gap - junctional protein connexin43 ( Cx43 ) are the cause of the human disease oculodentodigital dysplasia ( ODDD ) . - pubmed
Using two mutant mouse models that mimic the ODDD phenotype ( I130T/+ and G60S/+ ) , we sought to uncover how altered Cx43 function may affect mandibular development . - pubmed
Overall , our results suggest that the morphological differences seen in G60S/+ and I130T/+ mouse mandibles are due to delayed ossification and suggest that mechanical forces may exacerbate the effects of ODDD on the skeleton . - pubmed
CONCLUSION : AD - related immune hub genes include B2 M , FYN , PIK3R1 , and PIK3CA , and lncRNAs LINC00836 and DCTN1 - AS1 potentially contribute to AD immune - related phenomena by regulating AD - related hub genes . - pubmed
Epidermal growth factor receptor ( EGFR ) is over - expressed in many cancer cells and is a good target for cancer therapy . - pubmed
CONCLUSIONS : This study clearly demonstrated that the anti - EGFR sdAbs could inhibit cancer cell growth in vitro and tumor growth in vivo . - pubmed
AIMS : Whether or not renal structural changes , especially arteriolar hyalinosis , are related to the rate of renal functional decline and increase in urinary albumin excretion ( UAE ) at the early stage of diabetic nephropathy in patients with type 2 diabetes is still unknown . - pubmed
IgG1 subclass restriction of oligoclonal IgG from cerebrospinal fluids and brain extracts in patients with multiple sclerosis and subacute encephalitides . - pubmed
Oligoclonal - IgG - containing cerebrospinal fluids ( CSF ) from patients with multiple sclerosis and subacute encephalitides were studied for IgG subclass distribution by immunoelectrophoretic and hemagglutination inhibition methods . - pubmed
A case of plasma cell leukemia , secreting light kappa chains , is reported . - pubmed
Glycoprotein concentration at cell extremities was accompanied by preferential maturation of virus particles from the same sites ; both vesicular stomatitis and influenza viruses budded predominantly from the vicinity of clustered blebs . - pubmed
This permissive action of growth hormone has been initially suggested by observation in growth hormone - deficient rats , mice ( dwarf mutants , and humans ( sporadic , hereditary or acquired growth hormone deficiency.(ABSTRACT TRUNCATED AT 400 WORDS ) - pubmed
Anti - insulin autoantibodies were detected by an ELISA assay in all the NOD mice studied throughout the entire period of observation . - pubmed
Autoantibodies reacting with the cytoplasm of islet cells in Bouin 's fixed pancreas sections , likely to be anti - insulin antibodies , were found in 47 to 58 % of the samples from NOD mice aged 75 to 150 days . - pubmed
A panel of 10 FITC - labelled lectins ( MPA , PNA , ConA , DBA , SBA , RCA-120 , WGA , UEA , GS - I , GS - II+ ) was applied to cryosections of seven specimens of normal urothelium . - pubmed
Blood angiotensinase activity in relation to the breakdown of angiotensin II amide and nonisotopic phenylthiocarbamyl - angiotensin II amide in hypertensive and normotensive patients . - pubmed
Patients with T cruzi infection have antibody to GP90 , whereas patients with leishmaniasis do not and the two infections can be distinguished in an ELISA system using this antigen . - pubmed
Circulating immune complexes and complement breakdown product C3d in glomerulonephritis and kidney transplantation . - pubmed
Circulating immune complexes ( CIC ) and the complement breakdown product C3d were measured in 81 patients with glomerulonephritis ( GN ) , 28 patients with early and 25 patients with long - term renal transplants . - pubmed
In patients with GN , CIC were detected in 19 and elevated C3d levels found in 45 patients . - pubmed
The highest levels of C3d were found in patients with membranoproliferative GN type I and II , diffuse sclerosing GN and GN secondary to SLE and Wegener ' s granulomatosis . - pubmed
No relationship was found between CIC and C3d , and the combination of CIC with C3d measurements did not help to characterize ' nephritogenic ' CIC . - pubmed
C3d was frequently elevated in patients with impaired renal function which may reflect an inflammatory ' nephritic ' process , but may also be due to a reduced renal elimination . - pubmed
Furthermore C3d was frequently elevated in patients with improving or decreasing renal function , and in patients with heavy proteinuria . - pubmed
CIC and elevated C3d were not related to onset of acute rejection episodes in early transplant patients nor to late renal graft failure . - pubmed
HBV DNA detected in the above assay was predominantly cytoplasmic ; it was associated with the presence of hepatitis B core antigen ( HBcAg ) in hepatocytes and HBeAg in serum , and to a lesser extent with cirrhosis and immunosuppression , but not with the presence of HBsAg in hepatocytes , nor with histological evidence of disease activity judged by the presence of piece - meal necrosis and lobular and portal tract inflammation . - pubmed
These findings support the view that liver HBcAg and serum HBeAg are markers of virus replication , and demonstrate that active liver disease in HBsAg - positive patients may occur with or without such markers of replication . - pubmed
[ C - reactive protein and orosomucoid as parameters of developmental monitoring and therapeutic effectiveness in neonatal sepsis ] . - pubmed
They propose serial determination of C - reactive - protein and an efficient control of treatment in neonatal sepsis . - pubmed
Among the serum samples analysed , increasing proportions of proteolysed IGFBP-3 were found in the following order : acromegalic patients , normal subjects , GH - deficient patients , pregnant women . - pubmed
The aim of this study was to assess the behavior of fasting serum glucose , C - peptide levels and OGTT in pancreatic cancer follow - up . - pubmed
[ Evaluation of serum adenosine deaminase as a prognostic marker in the treatment of human immunodeficiency virus infection with zidovudine ] . - pubmed
Wnt-1 null mutants exhibit cranial defects but no spinal cord abnormalities , despite expression of the gene in these regions . - pubmed
The absence of spinal cord abnormalities is thought to be due to a functional compensation of the Wnt-1 deficiency by related genes , a problem that has complicated the analysis of null mutants of other developmental genes as well . - pubmed
We induce similar mid- and hindbrain abnormalities as those seen in the Wnt-1 null mutant mice . - pubmed
Attenuation of Wnt-1 expression was also associated with cardiomegaly resulting in hemostasis . - pubmed
These findings are consistent with the possibility that a subset of Wnt-1 expressing cells include neural crest cells known to contribute to septation of the truncus arteriosus and to formation of the visceral arches . - pubmed
Tumor necrosis factor - alpha in malignant disease . - pubmed
PURPOSE : Due to its important role in immunoregulation , we have investigated serum levels of tumor necrosis factor - alpha ( TNF alpha ) , in children with newly diagnosed , untreated , malignant disease . - pubmed
PATIENTS AND METHODS : These levels have been related to the presence of infection and to the serum content of three other cytokines , namely interleukin-1 beta , interleukin-2 , and interferon - gamma . - pubmed
RESULTS : Children with leukemia had higher mean levels of TNF alpha ( 63.6 + /- 12.3 pg / ml ) than did children with solid tumors ( 21.5 + /- 4.2 pg / ml ) and control patients ( 10.5 + /- 2.6 pg / ml ) . - pubmed
TNF alpha levels in patients did not correlate with the levels of the other cytokines or with the presence of infection . - pubmed
CONCLUSIONS : Children with malignant disease often have elevated TNF alpha levels . - pubmed
This elevation is dependent on the malignant disease process itself , and could either reflect the host immunological response or tumor cell production of TNF alpha . - pubmed
Analysis of dystrophin gene deletions in patients from the Mexican population with Duchenne / Becker muscular dystrophy . - pubmed
On the basis of increased plasma renin activity and serum 17 alpha - hydroxyprogesterone concentration and decreased 21 - hydroxylase activity of the adenoma tissue , the patient was diagnosed as having systemic 21 - hydroxylase deficiency . - pubmed
In cases of adrenal incidentalomas with 21 - hydroxylase deficiency , the indications for surgical removal should be carefully considered . - pubmed
Treatment of woodchuck hepatitis virus infection in vivo with 2 ' , - 3 '- dideoxycytidine ( ddC ) and 2 ',- 3 '- dideoxycytidine monophosphate coupled to lactosaminated human serum albumin ( L - HSA ddCMP ) . - pubmed
Comparison of immunological changes between subcutaneous and intravenous route of administration of IL-2 in cancer patients . - pubmed
The effects of the route of administration of interleukin 2 ( IL-2 ) on the immunological parameters of patients with various malignancies were investigated . - pubmed
These results demonstrate that there is no significant difference in the immunological parameters in cancer patients receiving IL-2 via subcutaneous or intravenous routes and provide further support for the current trend for clinical trials to concentrate on outpatients subcutaneous administration . - pubmed
hCG research remains necessary for pregnancy diagnosis , but hCG dosage is essential only in case of programmed medical assistance or pathological pregnancy ( extrauterine pregnancy , hydatiform mole , choriocarcinoma ) . - pubmed
Over the last 4 - 5 years , there have been numerous reports on the discovery of small molecule inhibitors for potential therapeutic applications to a number of proliferative diseases , principally cancer and restenosis , where the over - expression of certain tyrosine kinases has been demonstrated . - pubmed
Further , NSAIDs may delay the healing of gastric mucosal ulcer , in part through suppression of HGF expression via inhibition of endogenous PG production . - pubmed
[ Circadian and seasonal variations of the activity of blood lymphocyte dehydrogenases during secondary immunodeficiency in women with acute inflammatory gynecologic diseases of nonspecific etiology ] . - pubmed
When GluR2 promoter activity was investigated by plasmid transfection into cultured cortical neurons , cortical glia , and C6 glioma cells , the promoter construct with the strongest activity , per transfected cell , was 29.4 - fold ( + /- 3.7 ) more active in neurons than in non - neural cells . - pubmed
Anticardiolipin antibodies ( aCL ) found in sera from patients with antiphospholipid syndrome recognize a cryptic epitope that appears on the beta2 - glycoprotein I ( beta2 - GPI ) molecule when beta2 - GPI interacts with a lipid membrane composed of negatively charged phospholipid or when beta2 - GPI is adsorbed on a polyoxygenated polystyrene plate . - pubmed
Nerve fibers and class II major histocompatibility complex ( MHC ) antigen - expressing dendritic cells have been known to gather in the dental pulp beneath carious lesions . - pubmed
In pulps affected by early caries , HLA - DR - positive dendritic cells aggregated mainly in the cell - free zone associated with bundles of PGP 9.5 - immuno - reactive nerve fibers . - pubmed
In pulps affected by advanced caries , the accumulated HLA - DR - positive cells and PGP 9.5 - immunoreactive nerve fibers showed close association with each other especially beneath the odontoblast layer : the cells even embraced the nerve fibers . - pubmed
The immunoreactivity for HLA - DR in Schwann cells depended upon the severity of the carious lesion . - pubmed
Differential glycosylation of the Cas - Br - E env protein is associated with retrovirus - induced spongiform neurodegeneration . - pubmed
Specifically , the expression of gp70 correlated with regions showing microglial infection and spongiform neurodegeneration . - pubmed
In contrast , regions high in neuronal infection and without neurodegenerative changes ( the cerebellum and olfactory bulb ) were characterized by a gp65 Env protein isoform . - pubmed
Taken together , these results indicate that differential posttranslational modification of the Cas - Br - E Env is associated with a failure to incorporate certain Env isoforms into virions in vivo , suggesting that defective viral assembly may be associated with the induction of spongiform neurodegeneration . - pubmed
However , hypothyroidism may present in a manner suggestive of an acute myocardial infarction with an elevated creatine kinase and electrocardiographic abnormalities . - pubmed
Human white matter from non - neurologic cases , multiple sclerosis ( MS ) and other neurologic diseases ( OND , inflammatory and non - inflammatory ) , was subjected to immunocytochemistry and Western blotting for expression of the neuregulin , glial growth factor-2 ( GGF2 ) , and its receptors , erbB2 , erbB3 and erbB4 . - pubmed
GGF2 has previously been shown to have mitogenic effects upon oligodendrocytes in vitro and an enhancing effect upon remyelination in animals with autoimmune demyelination . - pubmed
In all types of human white matter examined , expression of the ligand GGF2 and its three receptors was consistently found on oligodendrocytes , with higher levels being seen in cases of MS . - pubmed
GGF2 and erbB receptor expression did not correlate with areas of remyelination and reactivity occurred throughout the tissue , with some increase in intensity at the edge of MS lesions . - pubmed
Ciliary activity in allergics who developed a stress response postantigen challenge , as determined by an induction of the 27 kDa stress ( heat shock ) protein , displayed no ciliary dysfunction when exposed to a pH 5 stress . - pubmed
In this case , a stress sufficient to provoke a heat shock ( stress ) protein ( HSP ) response ( but not one that produced more severe lung injury and did not provoke an HSP response ) protected cells from a subsequent acid stress . - pubmed
RESEARCH DESIGN AND METHODS : A total of 18 patients after heart transplantation for end - stage heart disease ( age 47 + /- 3 years ; transplant age 5.5 + /- 1.5 years ; BMI 25.8 + /- 0.8 kg / m(2 ) ; cyclosporin A 4.2 + /- 0.6 mg/[kg.day ] ; azathioprine 0.87 + /- 0.31 mg/[kg.day ] ) , 12 patients with type 2 diabetes ( D - Tx ) , and 6 patients without type 2 diabetes ( Tx ) were studied by means of 1 ) an oral glucose tolerance test ( OGTT ) to assess the beta - cell secretory response , 2 ) a euglycemic - hyperinsulinemic ( 1 mU/[kg.min ] ) clamp combined with indirect calorimetry and a primed continuous infusion of [ 6,6 - 2H2 ] glucose and [ 1 - 13C ] leucine to measure postabsorptive and insulin - stimulated carbohydrate and protein metabolism , and 3 ) 1H - NMR spectroscopy of the calf muscles to measure intramyocellular triglyceride ( IMCL ) content . - pubmed
OBJECTIVE : To examine , in a retrospective analysis of outcome based on prostate - specific antigen ( PSA ) levels , whether the 1992 and revised 1997 staging criteria for prostate cancer can be used to predict progression - free survival for patients after radical prostatectomy for pT2 and pT3 prostate cancer . - pubmed
The subgroups of pT2 and pT3 disease were compared for the time to PSA progression , using Kaplan - Meier data analysis and the log - rank test . - pubmed
Molecular studies have confirmed that it is a heterogeneous disorder and there may be evidence for an autosomal recessive mode of inheritance.1 The gene responsible for Noonan ' syndrome has been mapped to the long arm of chromosome 12.2,3 The human deltex gene ( DLT x 1 ) , mapping to chromosomal region 12q24 in the vicinity of the Noonan ' s syndrome critical region is being evaluated as a candidate gene for this disorder.4 Various types of musculoskeletal abnormalities have been reported , including short stature , craniofacial dysmorphism , short or webbed neck and fetal pads in fingers and toes.5 We report five cases with the unusual physical features of overriding toes and simian creases . - pubmed
Electrophysiologic data indicated a diagnosis of MG and chronic inflammatory demyelinating polyneuropathy ; acetylcholine receptor antibody was elevated at 4.1 nmol / L ( normal < 2 nmol / L ) . - pubmed
Quinoline resistance in malaria is frequently compared with P - glycoprotein - mediated multidrug resistance ( mdr ) in mammalian cells . - pubmed
Monitoring of IgE - mediated food allergy in childhood . - pubmed
UNLABELLED : Testing for IgE - mediated allergy is performed to reach or refute a suspected allergy . - pubmed
Influence of orthostatic hypotension in Parkinson ' s disease on plasma atrial natriuretic peptide . - pubmed
The effect of orthostatic hypotension in Parkinson ' s disease ( PD ) on plasma atrial natriuretic peptide ( ANP ) was examined in fifteen individuals with PD without autonomic dysfunction ( 63 - 85 years ) , nine PD patients with autonomic dysfunction ( orthostatic hypotension ; systolic BP change & gt ; 20 mmHg after 5 min standing : 69 - 82 years ) and 14 fit elderly volunteers ( 62 - 93 years ) . - pubmed
The mean ANP level was 42.2 pg / ml ( range 16.8 - 89.2 pg / ml ) in the PD group without autonomic dysfunction ; 44.4 pg / ml ( range 27.2 - 91.2 pg / ml ) in the PD group with autonomic dysfunction ; and 48.5 pg / ml ( range 22.2 - 111.6 pg / ml ) in the elderly group . - pubmed
Targeted deletion of the SSTK gene in mice resulted in male sterility due to profound impairment in motility and morphology of spermatozoa . - pubmed
Insulin decrease following OE treatment was greater in lean CR than in H rats , but this trend was reversed in the obese rats , lacking effective responses to leptin . - pubmed
Being in a position that is likely to control well - characterized oncogene products suggested that the expression levels of the Sprouty genes may be relevant in human carcinogenesis . - pubmed
Early data on the deregulation of Sprouty expression in breast , prostate and liver cancers is discussed along with the notion that some of them might have potential as tumour markers or that the derived proteins may act as tumour suppressors . - pubmed
The relationship between serum concentration of cardiac troponin I in chronic renal failure patients and cardiovascular events . - pubmed
OBJECTIVE : The purpose of this study was to evaluate the relationship between serum cardiac troponin I in asymptomatic chronic renal failure patients and cardiovascular events . - pubmed
CONCLUSION : Elevated cTnI concentrations are commonly found in chronic renal failure patients . - pubmed
The AMI cutoff level of cTnI ( 0.4 ng / ml ) seem to have a benefit for predicting the cardiovascular events in asymptomatic chronic renal failure patients while the 0.08 ng / ml cutoff does n't have usefulness for this purpose . - pubmed
Mice heterozygous for a targeted disruption of the cystathionine beta - synthase gene ( Cbs+/- ) and wild - type littermates ( Cbs+/+ ) were fed either a control diet or a high methionine / low folate ( HM / LF ) diet for 6 to 8 months to produce graded hyperhomocysteinemia . - pubmed
Carotid artery thrombosis was not accelerated in mice deficient in endothelial nitric oxide synthase ( Nos3 ) , which suggests that decreased endothelium - derived nitric oxide is not a sufficient mechanism for enhancement of thrombosis . - pubmed
We conclude that hyperhomocysteinemia enhances susceptibility to arterial thrombosis through a mechanism that is not caused by loss of endothelium - derived nitric oxide but may involve oxidative stress and impairment of the protein C anticoagulant pathway . - pubmed
Alphastatin downregulates vascular endothelial cells sphingosine kinase activity and suppresses tumor growth in nude mice bearing human gastric cancer xenografts . - pubmed
AIM : To investigate whether alphastatin could inhibit human gastric cancer growth and furthermore whether sphingosine kinase ( SPK ) activity is involved in this process . - pubmed
Micro vessel density was analyzed in Factor VIII - stained tumor sections by the immunohistochemical SP method . - pubmed
CONCLUSION : Downregulating ECs SPK activity may be one of the mechanisms that alphastatin inhibits gastric cancer angiogenesis . - pubmed
Identifying helicase specific - inhibitors may lead to the development of drugs in the treatment of human cancers . - pubmed
Pain - related anxiety - like behavior requires CRF1 receptors in the amygdala . - pubmed
Corticotropin - releasing factor receptor CRF1 has been implicated in the neurobiological mechanisms of anxiety and depression . - pubmed
This study tested the hypothesis that CRF1 receptors in the amygdala are critically involved in pain - related anxiety . - pubmed
This study shows for the first time that CRF1 receptors in the amygdala contribute critically to pain - related anxiety - like behavior and nocifensive responses in a model of arthritic pain . - pubmed
We demonstrate that mitogen - activated protein kinase - activated kinase-2 ( MK2 ) is essential for localized Th2 - type inflammation and development of experimental asthma . - pubmed
Thus , the MK2 - HSP27 pathway is an excellent target for therapeutic control of localized inflammatory diseases . - pubmed
In this work , we demonstrated that the growth of the murine fibrosarcoma MC - C , was accompanied by manifestations of systemic inflammation , as demonstrated by an increase in both the number of circulating polymorphonuclear neutrophils ( PMN ) and the serum concentration of the proinflammatory cytokines interleukin-1beta ( IL-1beta ) , interleukin-6 ( IL-6 ) and tumor necrosis factor - alpha ( TNF - alpha ) and the acute phase proteins C reactive ( CRP ) and serum A amyloid ( SAA ) . - pubmed
Multivariate analysis demonstrated that independent predictors of MRSA bacteraemia ( vs. no bacteraemia ) were injection drug use ( IDU ) , end - stage renal disease ( ESRD ) and CD4 count & lt;200 cells / microL. - pubmed
CONCLUSIONS : MRSA bacteraemia was an increasingly common diagnosis in our HIV - infected cohort , especially in patients with history of IDU , low CD4 cell count and ESRD . - pubmed
Phase 2 study of gemcitabine and irinotecan in metastatic breast cancer with correlatives to determine topoisomerase I localization as a predictor of response . - pubmed
BACKGROUND : Gemcitabine incorporation into DNA enhances cleavage complexes in vitro when combined with topoisomerase I inhibitors and demonstrates synergy in cancer cells when given with irinotecan . - pubmed
Topoisomerase I localization can be measured in metastatic breast cancer . - pubmed
Zap-70 positive chronic lymphocytic leukemia co - existing with Jak 2 V671F positive essential thrombocythemia : a common defective stem cell ? - pubmed
We report two cases of ET with Jak 2 V617F in Zap-70 + CLL . - pubmed
Zap-70 expression in CLL correlates with non - mutated immunoglobulin genes . - pubmed
In DTg mice , Ang II - induced left ventricle hypertrophy and diastolic dysfunction without affecting systolic function , as assessed by echography . - pubmed
These effects were associated with an increase in the expression of collagens and fibronectin , matrix metalloproteinase 2 and matrix metalloproteinase 9 activities , and histological fibrosis . - pubmed
Ang II treatment of DTg mice did not affect inflammation markers , but oxidative stress was substantially increased , as indicated by gp91 expression , apocynin - inhibitable NADPH oxidase activity , and protein carbonylation . - pubmed
This observation may be relevant to the clinical use of MR or of combined Ang II type 1 receptor - MR antagonists for hypertrophic cardiomyopathies or for heart failure , particularly when diastolic dysfunction is associated with preserved systolic function . - pubmed
Intratumoral MVD was determined after mouse antihuman CD31 antibody immunostaining . - pubmed
In conclusion , we propose that HMC05 may be a safe and potent herbal formula against vascular inflammation , and its action may be attributable to the inhibition of ROS- and NF - kappaB - dependent expression of adhesion molecules and chemokines . - pubmed
Role of the AMPKgamma3 isoform in hypoxia - stimulated glucose transport in glycolytic skeletal muscle . - pubmed
We determined the role of the AMPKgamma3 isoform in hypoxia - mediated energy status signaling and glucose transport in fast - twitch glycolytic extensor digitorum longus ( EDL ) muscle from AMPKgamma3 - knockout ( KO ) mice and wild - type mice . - pubmed
Although hypoxia increased glucose transport ( P & lt ; 0.001 ) in wild - type mice , this effect was attenuated in AMPKgamma3 - KO mice ( 45 % reduction , P & lt ; 0.01 ) . - pubmed
KN-93 exposure reduced hypoxia - mediated glucose transport in AMPKgamma3 - KO and wild - type mice ( P & lt ; 0.05 ) . - pubmed
Basal and hypoxia - mediated phosphorylation of CaMKII , AMPK , and ACC as well as alpha1- and alpha2 - associated AMPK activity was comparable between AMPKgamma3 - KO and wild - type mice . - pubmed
KN-93 reduced hypoxia - mediated CaMKII phosphorylation in AMPKgamma3 - KO and wild - type mice ( P & lt ; 0.05 ) , whereas phosphorylation of AMPK and ACC as well as alpha1- and alpha2 - associated AMPK activity was unaltered . - pubmed
Taken together , we provide direct evidence for a role of the AMPKgamma3 isoform in hypoxia - mediated glucose transport in glycolytic muscle . - pubmed
Moreover , hypoxia - mediated TBC1D1 / D4 phosphorylation was uncoupled from glucose transport in AMPKgamma3 - KO mice , indicating that TBC1D1 / D4 - independent mechanisms contribute to glucose transport in skeletal muscle . - pubmed
Here , we discuss the different hypotheses to explain the induction of CD8(+ ) T cell responses in mycobacterial infections . - pubmed
Cap myopathy caused by a mutation of the skeletal alpha - actin gene ACTA1 . - pubmed
Mutations in TPM2 and TPM3 genes have been reported in cap myopathy so far . - pubmed
In addition to a new ACTA1 gene mutation , our case emphasizes the genetic heterogeneity of cap myopathy and its association with ACTA1 gene as well as the importance of repeat muscle biopsy in patients with undiagnosed muscle weakness . - pubmed
METHODS : To explore the renoprotective role of C - peptide in diabetic nephropathy ( DN ) , we reviewed the literature using PubMed for English language articles that contained key words related to C - peptide , kidney and DN . - pubmed
RESULTS : Numerous studies have demonstrated that C - peptide ameliorates a number of the structural and functional renal disturbances associated with uncontrolled hyperglycaemia in human and animal models of type 1 diabetes mellitus that lead to the development and progression of nephropathy , including abrogation of glomerular hyperfiltration , reduced microalbuminuria , decreased mesangial expansion and increased endothelial nitric oxide synthase levels . - pubmed
CONCLUSION : Burgeoning studies suggest that C - peptide is more than merely a link between the A and B chains of the proinsulin molecule and represents a future therapeutic tool in reducing complications of DN . - pubmed
Hashimoto ' s thyroiditis : TGAb , TPOAb , TRAb and recovery from hypothyroidism . - pubmed
Thyroglobulin antibody ( TGAb ) and thyroid peroxidase antibody ( TPOAb ) have been used to diagnose Hashimoto ' s thyroiditis . - pubmed
Patients with positive TGAb and/or TPOAb have been assumed to have Hashimoto ' s thyroiditis . - pubmed
Approximately 10 % of those with positive TGAb and/or TPOAb have hypothyroidism . - pubmed
TSBAb causes thyroid atrophy and hypothyroidism . - pubmed
TGAb and/or TPOAb do not necessarily cause hypothyroidism . - pubmed
Ischemia reperfusion induces IFN regulatory factor 4 in renal dendritic cells , which suppresses postischemic inflammation and prevents acute renal failure . - pubmed
Ischemia reperfusion ( IR ) activates TLRs causing subsequent sterile inflammation , for example in postischemic acute renal failure . - pubmed
We hypothesized that certain factors suppress APC activation and thereby limit sterile renal inflammation , for example , IFN regulatory factor 4 ( IRF-4 ) , an inducible inhibitor of LPS signaling . - pubmed
Lack of IRF4 aggravated acute renal failure 24 h after renal artery clamping together with increased intrarenal expression of TNF - alpha , IL-6 , CXCL2 , and CCL2 as well as excessive tubular necrosis and peritubular neutrophil influx as compared with wild - type IR kidneys . - pubmed
This effect almost entirely depended on the role of IRF4 to suppress TNF - alpha release by intrarenal APCs because either clodronate liposome depletion of these cells or TNF - alpha blockade with etanercept entirely abrogated the aggravation of cytokine expression and acute renal failure in Irf4 - deficient mice . - pubmed
Thus , loss - of - function mutations in the IRF4 gene predispose to IR injury because the postischemic induction of IRF4 in resident APCs like CD11c(+ ) dendritic cells , suppresses them to secrete TNF - alpha , and thereby limits inappropriate immunopathology . - pubmed
The BH3 - only protein Bad confers breast cancer taxane sensitivity through a nonapoptotic mechanism . - pubmed
In this paper we report that the proapoptotic BH3 - only protein Bad has a major role in taxane - induced cell death in vitro , and clinically is a prognostic indicator for overall survival of breast cancer patients after adjuvant taxane chemotherapy . - pubmed
They also suggest that cells expressing Bad are more sensitive to taxanes because of their altered cell cycle dynamics and reveal a clinically relevant proliferative role of Bad in breast cancer . - pubmed
Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma . - pubmed
The ubiquitination modulator COP1 regulates p53 activity by ubiquitination and it is frequently overexpressed in human HCC . - pubmed
In this study , we tested the hypothesis that COP1 blockade by short interfering RNA ( siRNA)-mediated inhibition could affect the course of HCC progression . - pubmed
The COP1 isoform COP1 - 1 was selected as the most effective target for siRNAs in terms of growth inhibition and apoptotic induction in several HCC cell lines . - pubmed
Growth inhibition occurred in HCC cells that retained wild - type p53 or expressed mutant p53 ( Y220C or R249S ) , whereas p53 - null Hep3B cells were resistant . - pubmed
In an orthotopic mouse xenograft model of HCC , systemic delivery of a modified COP1 siRNA by stable nucleic acid - lipid particles suppressed neoplastic growth in liver without unwanted immune responses . - pubmed
Our findings offer a first proof of principle that COP1 can be a promising target for systemic therapy of HCC . - pubmed
PURPOSE : To characterize the population pharmacokinetics of subcutaneous ustekinumab , a human IgG1Kappa ; monoclonal antibody against interleukin-12 / 23p40 , using data from a randomized , double - blind , placebo - controlled Phase II study in patients with active psoriatic arthritis ( PsA ) . - pubmed
Moreover , formation of intercellular gaps in endothelial monolayers was observed , exposing subendothelial extracellular matrix ( ECM ) on which colon carcinoma cells adhered via integrin molecules . - pubmed
Fluoro - Jade labeling revealed that marked loss of CGRP - imunoreactive DRG sensory neurons is not due to neuronal degeneration . - pubmed
Therapeutic strategies to target multiple kinases in glioblastoma . - pubmed
Despite the initial enthusiasm in exploring kinase inhibitors for GBM , first - generation kinase inhibitors that selectively disrupt single kinases have failed to demonstrate clinical benefit in most patients with GBM . - pubmed
One strategy to circumvent this challenge is to target multiple kinases by multitargeted kinase inhibitors or combinations of single targeted kinase inhibitors , both of which have been evaluated in clinical trials for GBM . - pubmed
Fascioloides magna infected deer with fibrous capsules and migratory lesions had significantly higher values for lactate dehydrogenase ( LDH ) , glutamate dehydrogenase ( GLDH ) and globulin , and lower values for albumin / globulin ratio and glucose compared to uninfected deer . - pubmed
Transient receptor potential channels ( TRPs ) regulate tumor growth via calcium - dependent mechanisms . - pubmed
The ( thermosensitive ) capsaicin receptor TRPV1 is overexpressed in numerous highly aggressive cancers . - pubmed
TRPV1 has potent antiproliferative activity and is therefore potentially applicable in targeted therapy of malignancies . - pubmed
Recently , we characterized TRPM8 functions in pancreatic neuroendocrine tumors ( NETs ) , however , the role of TRPV1 is unknown . - pubmed
To confirm the role of IL-16 in CAV development , C - H-2(bm12)KhEg ( H-2(bm12 ) ) donor hearts were transplanted into C57BL/6J WT recipients treated with ( 1 ) anti - IL-16 - neutralization monoclonal antibody or ( b ) control immunoglobulin G. - pubmed
Donor hearts transplanted into IL-16(-/- ) recipients had a significant reduction in coronary artery luminal occlusion , intima - to - media ratio , and percentage of diseased vessels . - pubmed
CAV was associated with decreased donor organ inflammation , as well as donor organ cytokine ( IL-1beta and IL-6 ) and chemokine ( MCP-1 and KC ) protein expression . - pubmed
, Feline Immunodeficiency Virus ( FIV ) , and Toxoplasma gondii IgG were detected in all three species with mean respective prevalence as follows : puma 16 % , 41 % and 75 % ; bobcat 31 % , 22 % and 43 % ; domestic cat 45 % , 10 % and 1 % . - pubmed
Using this Lactococcus lactis expressing the PAMI , we prepared yogurt and fed it to diabetic mice models . - pubmed
OBJECTIVE : To determine the effect of increasing oral doses of vitamin D ( 3 ) on serum 25 -( OH ) D and serum parathyroid hormone ( PTH ) levels in postmenopausal white women with vitamin D insufficiency ( defined as a 25 -[ OH ] D level & lt;=50 nmol / L ) in the presence of adequate calcium intake . - pubmed
Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis . - pubmed
Because activation of the contact proteases factor XII ( FXII ) , prekallikrein , and factor XI ( FXI ) can trigger coagulation and inflammatory responses , the contact factors have been considered potential targets for the treatment of sepsis . - pubmed
We therefore investigated whether an anticoagulant antibody ( 14E11 ) that selectively inhibits prothrombotic FXI activation by activated FXII ( FXIIa ) modifies the course of bowel perforation - induced peritoneal sepsis in mice . - pubmed
These data suggest that severe polymicrobial abdominal infection induces prothrombotic FXI activation , to the detriment of the host . - pubmed
Systemic anticoagulation by inhibiting FXI activation or FXIIa procoagulant activity during sepsis may therefore limit the development of disseminated intravascular coagulation without increasing bleeding risks . - pubmed
The WAKE - UP trial is an investigator initiated , European , randomized , double - blind , placebo - controlled trial designed to test efficacy and safety of MRI - based thrombolysis with alteplase ( tPA ) in stroke patients with unknown time of symptom onset , e.g. - pubmed
Chromatin remodelling enzymes such as the histone deacetylases ( HDACs ) and histone demethylases such as lysine - specific demethylase 1 ( LSD1 ) have been validated as targets for cancer drug discovery . - pubmed
We have developed multiple series of HDAC inhibitors and LSD1 inhibitors that promote the re - expression of aberrantly silenced genes that are important in human cancer . - pubmed
The arginine methyltransferase PRMT5 - MEP50 is required for embryogenesis and is misregulated in many cancers . - pubmed
Presenilin comprises the catalytic subunit of gamma - secretase , a protease responsible for the generation of amyloid - beta peptides causative of Alzheimer disease . - pubmed
Adaptive responses to tissue injury : role of heme oxygenase-1 . - pubmed
Bone - seeking tracers like 99mTc - DPD and pyrophosphate are beginning to have a role in imaging transthyretin cardiac amyloidosis . - pubmed
Circulating interleukin-8 and plasminogen activator inhibitor-1 are increased in women with ovarian carcinoma . - pubmed
Elevated serum levels of several cytokines have been reported in ovarian cancer . - pubmed
The aims of this study were to evaluate the diagnostic and prognostic value of multiple serum cytokines in women with ovarian tumors , and to examine possible associations between serum levels of cytokines and the previously analyzed HGF . - pubmed
Preoperative levels of multiple cytokines were quantified by serum - based immunoassays in 113 women with a pelvic mass : 57 carcinomas , 23 borderline tumors , and 33 benign ovarian tumors . - pubmed
The women with ovarian carcinoma had significantly higher preoperative serum levels of cancer antigen 125 ( CA 125 ) , interleukin 8 ( IL-8 ) , and plasminogen activator inhibitor-1 ( PAI-1 ) than women with benign ovarian tumors . - pubmed
Serum levels of IL-8 and PAI-1 were elevated in women with ovarian carcinoma compared to women with benign ovarian tumors , and positively correlated to serum HGF levels in women with ovarian tumors . - pubmed
Urinary protease inhibitor Serpin B3 is higher in women and is further increased in female patients affected by aldosterone producing adenoma . - pubmed
The proteomic analysis showed a different expression of Serpin B3 Inhibitor - SCCA1 ( SB3 ) in APA and BAH patients . - pubmed
Neither messenger RNA nor SB3 protein were identified in tissue obtained from adrenal tumors and from the surrounding normal gland . - pubmed
Altogether , this work details the striatal subsynaptic distribution of some of the main nAChRs subunits , underlining the possible relevance of striatal nAChRs in controlling neurotransmission , with potential relevance for Parkinson ' s disease , nicotine addiction and other dopaminergic disorders . - pubmed
TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese . - pubmed
Single nucleotide polymorphisms ( SNPs ) in the regulatory regions of TPH2 gene may affect gene expression and biosynthesis of 5 - HT triggering to various neuropsychiatric disorders related to 5 - HT dysfunction . - pubmed
The present study explored the association of SNPs within the TPH2 gene with paranoid schizophrenia in Han Chinese . - pubmed
A total of 164 patients with schizophrenia and 244 healthy controls were genotyped for six TPH2 SNPs ( rs4570625 , rs11178997 , rs11178998 , rs41317118 , rs17110747 , and rs41317114 ) . - pubmed
Our findings suggest that common genetic variations of TPH2 are likely to contribute to genetic susceptibility to paranoid schizophrenia in Han Chinese . - pubmed
IL-22 gets to the stem of colorectal cancer . - pubmed
Cytokines can provide survival and proliferation signals to cancer cells , thus promoting tumor progression . - pubmed
( 2014 ) reveal that interleukin-22 can also promote " stemness " in human colorectal cancer via transcription factor STAT3 - mediated epigenetic regulation of stem cell genes . - pubmed
The variant rs8048002 T>C in intron 3 of the MHC2TA gene is associated with risk of developing acute coronary syndrome . - pubmed
Recently , an intronic single nucleotide polymorphism ( rs8048002 ) in the MHC class II transactivator gene ( MHC2TA ) was shown to be associated with increased susceptibility to several inflammatory diseases . - pubmed
The aim of the present study was to test for an association between this MHC2TA gene polymorphism and susceptibility to the risk of developing acute coronary syndromes ( ACS ) in a group of Mexicans patients . - pubmed
The single nucleotide polymorphism ( rs8048002 ) of the MHC2TA gene was analyzed by 5 ' exonuclease TaqMan genotyping assays in a group of 452 patients with ACS and 456 healthy controls . - pubmed
In summary , our data suggest that the MHC2TA rs8048002 C>T gene polymorphism plays an important role in the risk of developing ACS . - pubmed
Association between serum osteocalcin levels and non - alcoholic fatty liver disease in women . - pubmed
BACKGROUND AND AIMS : Osteocalcin was found to have a significant role in insulin resistance . - pubmed
However , the relationship between serum osteocalcin level and NAFLD is not well known . - pubmed
RESULTS : Serum osteocalcin level was independently associated with menopausal status , bone mineral density , calcium , phosphate , alkaline phosphatase , fasting blood glucose , triglyceride , low - density lipoprotein cholesterol , alanine aminotransferase , gamma - glutamyltransferase , and NAFLD . - pubmed
When women were grouped according to their menopausal status and bone mineral density , the serum osteocalcin level showed an independent inverse association with NAFLD in premenopausal women without osteopenia or osteoporosis ( n = 2,941 ) [ odd ratio ( OR ): 0.94 , 95 % confidence interval ( CI ): 0.91 - 0.96 , p & lt ; 0.001 ] and postmenopausal women without osteopenia or osteoporosis ( n = 2,155 ) ( OR : 0.96 , 95 % CI : 0.95 - 0.98 , p & lt ; 0.001 ) , however , not in premenopausal ( n = 308 ) or postmenopausal women ( n = 1,663 ) with osteopenia or osteoporosis . - pubmed
CONCLUSIONS : The serum osteocalcin level was an independent factor associated with NAFLD , especially for women with normal bone mineral density . - pubmed
Qiliqiangxin Protects Against Cardiac Ischemia - Reperfusion Injury via Activation of the mTOR Pathway . - pubmed
The determination of serum and urinary endocan concentrations in patients with bladder cancer . - pubmed
Background Endocan ( endothelial cell - specific molecule-1 ) is a proteoglycan and plays an important role in angiogenesis and inflammation . - pubmed
The aim of this study was to evaluate of serum and urinary concentrations of endothelial cell - specific molecule-1 in bladder cancer . - pubmed
Results In bladder cancer group , serum and urinary endothelial cell - specific molecule-1 concentrations were significantly higher than in the healthy subjects ( P = 0.003 and P & lt ; 0.0001 ) . - pubmed
Urinary endothelial cell - specific molecule-1 concentrations in cases with urinary tract infection were higher than in healthy volunteers ( P = 0.002 ) . - pubmed
There were no significant differences between bladder cancer and urinary tract infection groups in terms of serum and urinary endothelial cell - specific molecule-1 concentrations . - pubmed
Urinary endothelial cell - specific molecule-1 concentrations were higher than those of corresponding serum endothelial cell - specific molecule-1 concentrations ( P & lt ; 0.0001 for bladder cancer and urinary tract infection groups , P = 0.002 for healthy subjects ) . - pubmed
In bladder cancer group , there was a positive correlation between serum endothelial cell - specific molecule-1 and urinary endothelial cell - specific molecule-1 concentrations ( r = 0.32 , P = 0.002 ) . - pubmed
Conclusion Serum and urinary endothelial cell - specific molecule-1 concentrations increase in bladder cancer . - pubmed
Fetal Anemia and Hydrops Fetalis Associated with Homozygous Hb Constant Spring ( HBA2 : c.427 T & gt ; C ) . - pubmed
Hb Constant Spring ( Hb CS , HBA2 : c.427 T & gt ; C ) is a common nondeletional alpha - thalassemia ( alpha - thal ) that results from a nucleotide substitution at the termination codon of the alpha2 - globin gene . - pubmed
Homozygosity for Hb CS ( alpha ( CS ) alpha / alpha ( CS ) alpha ) is relatively rare , and generally characterized with mild hemolytic anemia , jaundice , and splenomegaly . - pubmed
Fetal blood sampling revealed the severe anemia [ hemoglobin ( Hb ) level being 4.8 g / dL ] and Hb H ( beta4 ) disease - like hematological findings with Hb Bart ' s ( gamma4 ) level of 17.9 % . - pubmed
DNA sequencing of the alpha - globin genes found that both partners were Hb CS carriers and the fetus was an Hb CS homozygote . - pubmed
Functional and genetic screening of acute myeloid leukemia associated with mediastinal germ cell tumor identifies MEK inhibitor as an active clinical agent . - pubmed
A shared clonal origin was demonstrated through identification of identical NRAS and TP53 somatic mutations in both malignancies . - pubmed
Glucagon - like peptide-1 receptor agonists in the treatment of type 2 diabetes : Past , present , and future . - pubmed
Glucagon - like peptide-1 ( GLP-1)-based therapy improves glycaemic control through multiple mechanisms , with a low risk of hypoglycaemia and the additional benefit of clinically relevant weight loss . - pubmed
Transforming properties of Felis catus papillomavirus type 2 E6 and E7 putative oncogenes in vitro and their transcriptional activity in feline squamous cell carcinoma in vivo . - pubmed
In addition , E6 and E7 inhibited ultraviolet B ( UVB)-triggered accumulation of p53 , p21 and pro - apoptotic markers such as Cleaved Caspase3 , Bax and Bak , suggesting a synergistic action of the virus with UV exposure in tumour pathogenesis . - pubmed
Importantly , we demonstrated mRNA expression of FcaPV2 E2 , E6 and E7 in feline SCC samples , strengthening the hypothesis of a causative role in the development of feline SCC . - pubmed
Sphingosine 1 - phosphate receptor 1 is required for retinal ganglion cell survival after optic nerve trauma . - pubmed
In this study , we used a classical optic nerve injury model to address the function of the sphingosine 1 - phosphate ( S1P )- S1P receptor ( S1PR ) axis in retinal ganglion cell ( RGC ) death and axonal growth . - pubmed
Moreover , retinal infection with AAV2.shRNA - S1PR1 down - regulated mammalian target of rapamycin pathway activation in alphaRGCs . - pubmed
The role of sphingosine 1 - phosphate receptor 1 ( S1PR1 ) was studied in retinal ganglion cell survival and axonal growth after optic nerve injury . - pubmed
After axonal damage , S1PR1 expression was decreased in retinal neurons . - pubmed
Synthesis , cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines . - pubmed
We show that lysine acetyltransferase 6A ( KAT6A ) is responsible for maintaining permissive Cd8 gene transcription and enabling robust effector responses during infection . - pubmed
More precisely , recent studies have shown that FXR is important for glucose homeostasis in particular in metabolic disorders such as T2D and obesity . - pubmed
Anti - cancer activity of Annexin V in murine melanoma model by suppressing tumor angiogenesis . - pubmed
Annexin V in inhibiting engulfment of apoptotic cells by macrophages had been reported to increase the immunogenicity of tumor cells undergoing apoptosis . - pubmed
Treatment with Annexin V showed significant reduction in tumor size and remarkable tumor necrosis areas . - pubmed
The serum level of VEGF was downregualted by Annexin V both in normal mice and mice bearing tumor , suggesting that its new role on impeding tumor angiogenesis . - pubmed
In Silico analysis using Oncomine database , we also found the negative correlation of AnnexinV and VEGF both in skin and melanoma . - pubmed
These data provided a possibility that Annexin V can be used as a novel angiogenesis inhibitor in tumor therapy . - pubmed
Organotypic models of type III interferon - mediated protection from Zika virus infections at the maternal - fetal interface . - pubmed
Here , we developed 3D cell - line - based models of human syncytiotrophoblasts , cells that lie in direct contact with maternal blood , and show that these cells recapitulate the antiviral properties of primary trophoblasts through the constitutive release of type III IFNs ( IFNlambda1 and IFNlambda2 ) and become resistant to ZIKV infection . - pubmed
In addition , using organotypic human midgestation chorionic villous explants , we show that syncytiotrophoblasts isolated from the second trimester of pregnancy also constitutively release type III IFNs and use these IFNs in autocrine and paracrine manners to restrict ZIKV infection . - pubmed
Collectively , these data provide important insights into the defense mechanisms used by syncytiotrophoblasts at various stages of human gestation to resist ZIKV infection and new human models to study the role of type III IFNs in the vertical transmission of ZIKV and other viruses associated with congenital disease . - pubmed
Subjects with any form of uveitis , a positive TB interferon - gamma release assay or tuberculin skin test , and negative evaluation for other causes of uveitis were included . - pubmed
Involvement of mGluR I in EphB / ephrinB reverse signaling activation induced retinal ganglion cell apoptosis in a rat chronic hypertension model . - pubmed
EphB / ephrinB reverse signaling is involved in retinal ganglion cell ( RGC ) apoptosis in experimental glaucoma . - pubmed
Here , we further investigated the mechanisms underlying EphB / ephrinB reverse signaling activation induced RGC apoptosis in a rat chronic ocular hypertension ( COH ) model , using patch - clamp techniques in retinal slices . - pubmed
Appropriate reduction of EphB / ephrinB reverse signaling could alleviate the loss of RGCs in glaucoma . - pubmed
Neratinib is a tyrosine kinase inhibitor that has been approved by the US Food and Drug Administration for the treatment of breast cancer . - pubmed
Struggle with Pharmacotherapy for Underactive Bladder : Could Patients with Detrusor Underactivity Benefit from Transient Receptor Potential Vanilloid 4 Agonists ? - pubmed
Thus , we concluded that AT1 pathway plays a role in pulmonary vascular dysfunction by increasing oxidative stress and reducing NO bioavailability , thereby contributing to vascular remodeling and pulmonary hypertension of iron - overload . - pubmed
Negative correlations were observed pre - PD ( regional CBF in left hippocampus vs. perseverative responses , r = -0.662 , p = 0.014 ) , post - PD ( mean CBF vs. haemoglobin level , r = -0.766 , p = 0.002 ) , and before and after PD ( change in CBF in the left putamen vs. change in haematocrit percentage , r = -0.808 , p = 0.001 ) . - pubmed
, haemoglobin level or haematocrit percentage , might predict cognitive impairment in PD patients . - pubmed
Value proposition of PSMA - targeted alpha - particle radioligand therapy in metastatic prostate cancer . - pubmed
A PSA decrease and some reduction of the radiotracer uptake ( SUV ) in tumor lesions occurred in 60 % and 70 % of the patients , respectively . - pubmed
Glucagon - Like Peptide-1 Secretion in Pre - Diabetes Revisited . - pubmed
COL1A1 / 2 Pathogenic Variants and Phenotype Characteristics in Ukrainian Osteogenesis Imperfecta Patients . - pubmed
Although up to 90 % of patients harbor pathogenic variants in the COL1A1 / 2 gene , which codes for collagen alpha1 / 2 chains , the spectrum of OI genotypes may differ between populations , and there is academic controversy around OI genotype - phenotype correlations . - pubmed
OI phenotype severity was highly correlated with type of collagen I defect . - pubmed
The current article presents an analysis of the clinical manifestations and COL1A1 / 2 mutational spectrum of 94 Ukrainian OI families with 27 novel COL1A1 / 2 pathogenic variants . - pubmed
The overall results indicated that MPS could induce cytogenotoxicity through the exacerbation of ROS production and inhibition of cdc2 . - pubmed
Information on sex , age at first biologic treatment , results of interferon - gamma release assay ( IGRA ) for Mycobacterium tuberculosis , treatment history with isoniazid , and onset of active and/or latent tuberculosis was collected . - pubmed
Active tuberculosis developed in two patients after the administration of tumor necrosis factor inhibitors ( both involved miliary tuberculosis ) . - pubmed
Latent tuberculosis was observed in two patients treated with anti - interleukin-12/23p40 antibody . - pubmed
Higher CCL22 + Cell Infiltration is Associated with Poor Prognosis in Cervical Cancer Patients . - pubmed
The chemokine CCL22 recruits regulatory T ( T - reg ) cells into tumor tissues and is expressed in many human tumors . - pubmed
However , the prognostic role of CCL22 in cervical cancer ( CC ) has not been determined . - pubmed
This study retrospectively analyzed the clinical significance of the expression of CCL22 and FOXP3 in 230 cervical cancer patients . - pubmed
CCL22 was primarily expressed in M2 - like macrophages in CC and induced by cervical cancer cells . - pubmed
The findings of our study indicate that cervical cancer patients with elevated CCL22 + infiltrating cells require more aggressive treatment . - pubmed
A 24 - week study demonstrated that sodium benzoate , a D - amino acid oxidase ( DAAO ) inhibitor , surpassed placebo in improving cognitive function in early - phase Alzheimer ' s disease ; however , benzoate did not excel placebo in another 6 - week study on BPSD . - pubmed
Finally , enzyme - linked immunosorbent assays revealed that the levels of annexin A5 , neutrophil gelatinase - associated lipocalin ( NGAL ) , and protein S100 - P were significantly higher in the samples of the first urine from patients with AKI than in those from patients without AKI . - pubmed
In conclusion , urinary annexin A5 , NGAL and protein S100 - P levels are promising biomarkers for early , accurate prediction of AKI in preterm infants . - pubmed
Circular RNA has_circ_0000527 participates in proliferation , invasion and migration of retinoblastoma cells via miR-646 / BCL-2 axis . - pubmed
In conclusion , circ_0000527 could promote the development of RB by indirectly modulating BCL-2 via absorbing miR-646 . - pubmed
HIF-1alpha - dependent miR-424 induction confers cisplatin resistance on bladder cancer cells through down - regulation of pro - apoptotic UNC5B and SIRT4 . - pubmed
RESULTS : In this study , we have found for the first time that cisplatin ( CDDP ) induces the expression of miR-424 in a HIF-1alpha - dependent manner under normoxia , and miR-424 plays a vital role in the regulation of CDDP resistance of bladder cancer cells in vitro . - pubmed
CDDP - mediated suppression of xenograft bladder tumor growth was prohibited by the addition of miR-424 , whereas ectopic expression of UNC5B or SIRT4 partially restored miR-424 - dependent decrease in CDDP sensitivity of bladder cancer 5637 and T24 cells . - pubmed
There existed a clear inverse relationship between the expression levels of miR-424 and pro - apoptotic UNC5B or SIRT4 in bladder cancer tissues . - pubmed
CONCLUSIONS : Collectively , our current results strongly suggest that miR-424 tightly participates in the acquisition / maintenance of CDDP - resistant phenotype of bladder cancer cells through down - regulation of its targets UNC5B and SIRT4 , and thus combination chemotherapy of CDDP plus HIF-1alpha / miR-424 inhibition might have a significant impact on hypoxic as well as normoxic bladder cancer cells . - pubmed
Role of proteinase - activated receptors 1 and 2 in nonsteroidal anti - inflammatory drug enteropathy . - pubmed
Proteinase - activated receptors 1 ( PAR1 ) and PAR2 are involved in the pathophysiology of several digestive disorders . - pubmed
This study examines the contribution of PAR1 and PAR2 in NSAID - induced small intestinal injury , and to investigate the underlying mechanisms . - pubmed
RESULTS : Indomethacin elicited a significant intestinal damage , associated with a decrease in blood hemoglobin and an increase in tissue MPO , MDA and fecal calprotectin . - pubmed
CONCLUSIONS : PAR2 is involved in the pathogenesis of indomethacin enteropathy , through pro - inflammatory mechanisms and an impairment of the intestinal epithelial barrier . - pubmed
PAR1 activation and PAR2 inhibition could represent suitable strategies for the prevention of NSAID enteropathy . - pubmed
Preclinical PET imaging with the novel human antibody 89Zr - DFO - REGN3504 sensitively detects PD - L1 expression in tumors and normal tissues . - pubmed
BACKGROUND : Programmed cell death protein 1 / programmed death - ligand 1 ( PD-1 / PD - L1 ) blocking antibodies including cemiplimab have generated profound clinical activity across diverse cancer types . - pubmed
Tumorous PD - L1 expression , as assessed by immunohistochemistry ( IHC ) , is an accepted predictive marker of response to therapy in some cancers . - pubmed
Epstein - Barr virus - immune complexes in postmortem kidneys from African patients with Burkitt ' s lymphoma and American patients with and without lymphoma . - pubmed
Increased ornithine decarboxylase activity in kidneys undergoing hypertrophy in experimental diabetes . - pubmed
This was done by measuring the activity of the rate - limiting enzyme in the polyamine pathway ( ornithine decarboxylase ; ODC ) in kidneys from control , diabetic and insulin - treated diabetic animals . - pubmed
The ODC activity in the kidney was increased in the diabetic animals with a maximal rise 24 h after diabetes induction ( 6 - fold , P less than 0.01 ) ; the activity thereafter declined . - pubmed
In insulin - treated diabetic animals the kidney ODC activity was only increased 3 - fold ( P less than 0.05 ) after 24 h , and for the rest of the study period the activity was about 1.8 - fold higher than in control rats . - pubmed
After 14 days the kidneys from diabetic rats were significantly larger than kidneys from both control and insulin - treated diabetic rats , 1066 + /- 43 mg vs. 904 + /- 16 mg and 959 + /- 36 mg , respectively ( P less than 0.01 ) . - pubmed
However , in muscle from diabetic animals the ODC activity declined steadily during the 14 days to 34 % of control values ( P less than 0.01 ) , and insulin treatment completely normalized the ODC activity in muscle. - pubmed
However , in the rat optic nerve PDGF levels increased after axonal injury , whereas in the fish optic nerve injury was accompanied by an apparent decrease in PDGF - like levels . - pubmed
These findings indicate that the CD4 + Th defect seen in the majority of asymptomatic , HIV+ individuals is not limited to recall antigens , but also extends to the component of the response to HLA alloantigens that involves the self - restricted , CD4 + Th pathway . - pubmed
Thus , the Th defect observed in asymptomatic , HIV+ patients does not involve a CD4 + Th defect per se , but is limited to the HLA self - restricted component of Th function . - pubmed
Such a reduction in the TH / S ratio and in the number of circulating suppressor cells was not found in esophagitis due to either HSV or Candida and was unrelated to the serum cyclosporine level or prednisone dosage prescribed. - pubmed
The cytochrome P450 - dependent enzyme aminopyrine N - demethylase , consistently depressed in hepatocarcinogenesis models in mouse and rat , does not show a significant change among normal , preneoplastic and neoplastic mammary tissues . - pubmed
glutathione - S - transferases and gamma - glutamyl transferase ) , active in the detoxification of xenobiotics , show no significant differences in carcinogen - induced tumors or in their homologous preneoplasias compared to control tissue . - pubmed
There is no increase in the anionic glutathione - S - transferase , a principal marker in rat hepatocarcinogenesis . - pubmed
All patients presented with typical hyperpigmentation of the skin and had abnormally raised plasma ACTH levels . - pubmed
Trans - sphenoidal microsurgical removal of Nelson 's ACTH adenomas were successful in seven of ten patients . - pubmed
Susceptibility of astrocytes to class I MHC antigen - specific cytotoxicity . - pubmed
We demonstrate that mouse astrocytes in vitro can be susceptible targets of class I major histocompatibility complex ( MHC)-specific cytotoxicity mediated by L3 cytotoxic T lymphocytes ( CTL ) . - pubmed
Ornithine decarboxylase and diamine oxidase activities showed maximal increases at 24 h in the striatum of the lesioned side , whereas in the substantia nigra ornithine decarboxylase attained a very high value as early as 4 h after the operation and diamine oxidase activity peaked at 48 h. The enzyme activities returned toward the basal values at 168 h. On the intact side , ornithine decarboxylase showed a small increase starting at 4 h and diamine oxidase was enhanced at 48 h. These results indicate that the stimulation of biosynthetic and degradative enzymes of polyamine metabolism accompanied by marked and prolonged increases in putrescine may be essential events in the early phases of neuronal response to mechanical injury in the CNS . - pubmed
HMG - CoA reductase inhibitors for treatment of hypercholesterolemia . - pubmed
[ Asparaginase for acute leukemia resistant to various chemotherapies ] . - pubmed
Production of interferon and other lymphokines during murine tumour growth . - pubmed
Lymphokines in cell -- free fluid of rat Zajdela ascites hepatoma . - pubmed
Cell - free ascites of rat Zajdela hepatoma was assayed for the presence of lymphokine - like factors . - pubmed
Macrophage migration inhibitory and microbial growth inhibitory cytokines were detected with peak activities at day 4 - 8 and 10 - 11 after tumour inoculation , respectively . - pubmed
In CHE cells , which possess telomeric repeats at both the terminal and interstitial regions , 39 % of the aberrations induced by AluI and PvuII showed telomeric repeat signals . - pubmed
Six patients with chronic refractory autoimmune thrombocytopenic purpura ( ATP ) were treated with five doses of autologous red blood cells ( RBCs ) opsonized ex vivo with anti - RhO -( D ) IgG. - pubmed
Three hundred and thirteen cases of human thyroid tissues , comprising 39 nodular goiters from 34 females and 5 males , 130 adenomas from 93 females and 37 males , and 144 carcinomas from 99 females and 45 males were used for the present immunohistochemical assessment of estrogen receptor ( ER ) expression . - pubmed
It was thus suggested that ER expression may be related to prognosis and tumor growth at early stage . - pubmed
Since the incidence of ER does not significantly differ between females and males , the observed sex differences regarding thyroid tumor incidence may reflect the higher estrogen serum content in females . - pubmed
Corticotropin - releasing factor up - regulates its own receptor gene expression in corticotropic adenoma cells in vitro . - pubmed
Patients with NIDDM had leptin concentrations similar to controls of similar weight . - pubmed
Importantly , serum levels of sTNF alpha - R55 were also positively and independently associated with leptin in this group of diabetic subjects and matched controls . - pubmed
Further elucidation of a possible role of the TNF alpha system in leptin expression and circulating levels may have important implications for our understanding of obesity and cachexia in humans . - pubmed
Crucial role of interleukin-10 / interleukin-12 balance in the regulation of the type 2 T helper cytokine response in reactive arthritis . - pubmed
OBJECTIVE : To investigate whether a predominant type 1 T helper ( Th1 ) or Th2 cytokine pattern is present in the joints of patients with reactive arthritis ( ReA ) , and whether the cytokine pattern can be modulated by cytokines or anticytokines . - pubmed
METHODS : Eleven patients with ReA following infection with either Chlamydia trachomatis , Yersinia enterocolitica , or Salmonella enteritidis were investigated for the presence of Th1 / Th2 cytokines in the joints . - pubmed
CONCLUSION : These data indicate that a Th2 cytokine pattern predominates in the joints of patients with ReA. - pubmed
Therefore , the IL-10 / IL-12 balance appears to be crucial for regulation of the cytokine pattern in the joints of patients with ReA. - pubmed
The present data support the clinical use of mature , rather than immature , tumor Ag - pulsed dendritic cells as cancer vaccines and identifies CD40L as a potent stimulus to enhance their in vivo Ag - presenting capacity . - pubmed
This investigation was based on the hypothesis that weakly immunogenic , breast cancer - associated Ags , the products of mutant or dysregulated genes in the malignant cells , will be expressed in a highly immunogenic form by semiallogeneic IL-2 - secreting fibroblasts transfected with DNA from breast cancer cells . - pubmed
To investigate this question , we transfected LM mouse fibroblasts ( H-2k ) modified to secrete IL-2 with genomic DNA from a breast adenocarcinoma that arose spontaneously in a C3H / He mouse ( H-2k ) . - pubmed
Vascular endothelial growth factor ( VEGF ) in children , adolescents and young adults with Type 1 diabetes mellitus : relation to glycaemic control and microvascular complications . - pubmed
AIMS : To evaluate serum levels of vascular endothelial growth factor ( VEGF ) in a large group of children , adolescents and young adults with Type 1 diabetes mellitus to investigate whether increased VEGF concentrations are associated with long - term glycaemic control and microvascular complications . - pubmed
RESULTS : VEGF serum levels were significantly increased in pre - school and pre - pubertal children with diabetes as well as in pubertal patients compared to controls . - pubmed
VEGF concentrations were markedly increased in adolescents and young adults with microvascular complications compared with both healthy controls and diabetic patients without retinopathy or nephropathy . - pubmed
In poorly controlled diabetic children ( HbA1c & gt ; 10 % ) , long - term ( 2 years ) improvement of glycaemic control ( aiming at HbA1c & lt ; 7 % ) resulted in a significant reduction of VEGF levels . - pubmed
CONCLUSIONS : VEGF serum concentrations are increased in prepubertal and pubertal children with diabetes . - pubmed
Severity of microvascular complications is associated with marked increase of VEGF concentrations in the serum of these patients . - pubmed
We postulate that the early drop - outs in the olanzapine - treated parkinsonian group may be attributable to a non - specific effect of the drug as a result of starting at too high a dose , and that the worsening of parkinsonism following prolonged treatment may have been caused by the drug 's blocking effect on striatal D2 receptors . - pubmed
The present expanded battery of immunohistochemical stains is presented on this rare tumor , including cytokeratin AE1 / AE3 , CK7 , CK20 , S100 protein , epithelial membrane antigen , alpha - smooth muscle actin , desmin , CD34 , CD99 , Bcl-2 , vimentin , estrogen and progesterone receptors , and Ki-67 . - pubmed
There was minimal expression of alpha - smooth muscle actin and negative staining with S100 protein , with coexpression of cytokeratins and vimentin and expression of estrogen and progesterone receptors , as previously reported in SCEVs . - pubmed
The rather high proportion of patients with elevated baseline serum tryptase levels necessitates further investigation of a possible association between mastocytosis and treatment failure of conventionally dosed VIT . - pubmed
We evaluated not only the levels of platelet cyclic AMP , but also cyclic GMP and nitric oxide synthase ( NOS ) activity in patients with PD at baseline and after treatment with clomipramine and in healthy volunteers . - pubmed
Platelet cyclic AMP was determined by enzymeimmunoassay , cyclic GMP by radioimmunoassay and NOS activity by the conversion of ( 3 ) H - arginine to ( 3 ) H - citruline in 17 PD patients before treatment with clomipramine , after remission of panic attacks and in 22 healthy volunteers . - pubmed
Northern blot analysis showed that RCC18 cDNA was highly expressed in RCC , but no signal could be detected in normal kidney . - pubmed
We have identified inactive , alternatively spliced dCK forms in leukemic blasts from patients with resistant AML . - pubmed
Because these dCK - spliced variants were only detectable in resistant AML , it was hypothesized that they might play a role in AraC resistance in vivo . - pubmed
[ Wilms tumor gene ( WT1 ) as a marker for minimal residual disease in leukemia ] . - pubmed
Von Hippel - Lindau disease ( VHL ) was diagnosed exclusively by VHL - gene analysis . - pubmed
Chemical inhibitors of cyclin - dependent kinases ( CDKs ) have a great therapeutic potential against various proliferative and neurodegenerative disorders . - pubmed
The pertussis component of this DTPa vaccine , developed by Glaxo SmithKline , consists of pertussis toxoid , filamentous haemagglutinin and pertactin . - pubmed
ADAM 33 : just another asthma gene or a breakthrough in understanding the origins of bronchial hyperresponsiveness ? - pubmed
[ Blood prothrombin during radiophosphorus and x - ray therapy of polycythemia and leukoses ] . - pubmed
Expression of mast cell tryptase in pediatric otitis media with effusion . - pubmed
OBJECTIVE : To evaluate the possible relationship between allergy and otitis media with effusion ( OME ) , we investigated the presence and level of tryptase , which reflect mast cell activity . - pubmed
Evidence for mast cell tryptase presence and degree of activation in the middle ear effusion ( MEE ) were measured by using Western blotting and radioimmunoassay ( RIA ) . - pubmed
RIA demonstrated that mean tryptase level was significantly higher in the MEE with allergy positive than negative . - pubmed
Bilirubin levels in G6PD - deficient neonates were somewhat higher compared to G6PD - normal babies ( 18.8 + /- 2.4 mg / dl [ 321.5 + /- 41 micromol / l ] vs. 15.7 + /- 3.2 mg / dl [ 268.5 + /- 54.7 micromol / l ] ; P & lt ; 0.05 ) . - pubmed
G6PD activity was significantly lower in G6PD - deficient group than in the normal group ( 2.1 + /- 0.7 vs. 12.5 + /- 5.0 U / g Hb ; P & lt ; 0.001 ) . - pubmed
CONCLUSION : This study shows that the incidence of G6PD deficiency in newborns of Tehran is 2.1 % , which is relatively high , and also hyperbilirubinemia and jaundice are approximately 3 - fold higher in G6PD - deficient group than in the G6PD - normal group ( 51 % vs. 16 % ) . - pubmed
Dual biological functions of an interleukin-1 receptor antagonist - interleukin-10 fusion protein and its suppressive effects on joint inflammation . - pubmed
Thyroid function tests revealed elevated serum thyroxine and triiodothyronine as well as low thyroid stimulating hormone concentrations , confirming the diagnosis of thyrotoxicosis . - pubmed
Ventilator - induced lung injury is reduced in transgenic mice that overexpress endothelial nitric oxide synthase . - pubmed
Because nitric oxide ( NO ) has been reported to play roles in the pathogenesis of acute lung injury , the present study explores the effects on VILI of NO derived from chronically overexpressed endothelial nitric oxide synthase ( eNOS ) . - pubmed
Anesthetized eNOS - transgenic ( Tg ) and wild - type ( WT ) C57BL/6 mice were ventilated at high or low tidal volume ( Vt ; 20 or 7 ml / kg , respectively ) for 4 h. After MV , lung damage , including neutrophil infiltration , water leakage , and cytokine concentration in bronchoalveolar lavage fluid ( BALF ) and plasma , was evaluated . - pubmed
In conclusion , chronic eNOS overexpression may protect the lung from VILI by inhibiting the production of inflammatory chemokines and cytokines that are associated with neutrophil infiltration into the air space . - pubmed
Use of aromatase inhibitors in children with short stature . - pubmed
The use of aromatase inhibitors may provide a means to delay skeletal maturation and increase final height in children with short stature . - pubmed
Diminished TLR function in IECs under the influence of Th2 cytokines may protect the host from excessive TLR signaling , but likely also impairs the host intestinal innate immune defense and increases IEC susceptibility to chronic inflammation in response to the intestinal microenvironment . - pubmed
In response to EGF , the sialidase redistributed rapidly to ruffling cell membranes of squamous carcinoma A431 cells and co - localized with Rac-1 . - pubmed
Twelve - week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes . - pubmed
UNLABELLED : Inhibition of dipeptidyl peptidase-4 enhances the activity of incretin hormones , improving glycemic control in subjects with type 2 diabetes . - pubmed
To date , 37 different uromodulin mutations have been described in patients with MCKD / FJHN . - pubmed
We assessed protein processing in the secretory pathway and could demonstrate that although to different extent , all uromodulin mutations lead to defective ER to Golgi protein transport , suggesting a common pathogenetic mechanism in MCKD / FJHN . - pubmed
Computed tomography severity index and C - reactive protein values predicting mortality in emergency and intensive care units for patients with severe acute pancreatitis . - pubmed
Linear backward regression analysis showed that high CRP values and respiratory failure on ICU admission correlate with longer ICU stay . - pubmed
High CRP , renal and respiratory failure , and male gender are associated with longer ICU stay . - pubmed
By enhancing sperm mitochondrial function , uPA may provide sufficient energy for capacitated - spermatozoa to increase their motility and change their motor pattern , which might be one of the therapeutic mechanisms of uPA on male infertility . - pubmed
[ Sequential acupuncture method for treatment of apoplexy hemiplegia and its effects on plasma ET-1 and NO levels ] . - pubmed
CONCLUSION : The sequential acupuncture method has an obvious therapeutic effect on apoplexy hemiplegia , and it can decrease plasma ET-1 level and increase NO level . - pubmed
Efferent vagal nerve stimulation induces tissue inhibitor of metalloproteinase-1 in myocardial ischemia - reperfusion injury in rabbit . - pubmed
We therefore investigated the effects of electrical stimulation of efferent vagal nerve on myocardial expression and activation of MMPs and TIMPs in a rabbit model of myocardial ischemia - reperfusion ( I / R ) injury . - pubmed
Total MMP-9 protein increased significantly after left coronary artery occlusion in I / R - VS and I / R to a similar degree compared with VS and sham values . - pubmed
In conclusion , in a rabbit model of myocardial I / R injury , vagal nerve stimulation induced TIMP-1 expression in cardiomyocytes and reduced active MMP-9 . - pubmed
Identification and in vitro expansion of functional antigen - specific CD25 + FoxP3 + regulatory T cells in hepatitis C virus infection . - pubmed
We report that HCV - infected patients display increased circulating FoxP3(+ ) Tregs that are phenotypically and functionally indistinguishable from FoxP3(+ ) Tregs in uninfected subjects . - pubmed
In conclusion , functionally active and virus - specific FoxP3(+ ) Tregs are induced in HCV infection , thus providing targeted immune regulation in vivo . - pubmed
DNA - repair genes , including X - ray repair cross - complementing group 1 ( XRCC1 ) and xeroderma pigmentosum group D ( XPD ) , may also be implicated in the process of pesticide - related carcinogenesis . - pubmed
Endothelial barrier protection by FTY720 under hyperglycemic condition : involvement of focal adhesion kinase , small GTPases , and adherens junction proteins . - pubmed
Furthermore , FTY720 conditioned the phosphorylation profile of FAK [ Y397 / Y576 / Y925 ] in hyperglycemic medium to the same pattern observed in normoglycemic medium . - pubmed
FTY720 challenge resulted in small GTPase Rac activation under hyperglycemic conditions , whereas increased Rho activity in hyperglycemic medium was restored to the basal level . - pubmed
These findings strongly suggest the barrier protective effect of FTY720 on HMVEC monolayers in hyperglycemic medium via S1P signaling , further implying the possibility of FTY720 as a therapeutic agent of diabetic vascular disorder . - pubmed
NFAT proteins : emerging roles in cancer progression . - pubmed
However , ubiquitous expression of NFAT isoforms in mammalian tissues has recently been observed , and a role for these transcription factors in human cancer is emerging . - pubmed
Various NFAT isoforms are functional in tumour cells and multiple compartments in the tumour microenvironment , including fibroblasts , endothelial cells and infiltrating immune cells . - pubmed
How do NFAT isoforms regulate the complex interplay between these compartments during carcinoma progression ? - pubmed
In addition to elucidating the complex role of NFATs in cancer , we face the challenge of targeting this pathway therapeutically . - pubmed
Kinins are vasoactive peptides that play important roles in cardiovascular homeostasis , pain and inflammation . - pubmed
The B2R is considered to mediate many of the acute effects of kinins while the B1R is more responsible for chronic responses in inflammation . - pubmed
Patients with dysglycemia related to known or unrecognized diabetes , stress hyperglycemia , or hypoglycemia in the presence or absence of exogenous insulin routinely require care during the perioperative period or critical illness . - pubmed
Amrubicin at a lower - dose with routine prophylactic use of granulocyte - colony stimulating factor for relapsed small - cell lung cancer . - pubmed
To overcome this clinical problem , we investigated whether 35 mg / m(2 ) of AMR administration with routine prophylactic use of granulocyte - colony stimulating factor ( G - CSF ) can reduce myelosuppression , while maintaining efficacy . - pubmed
CONCLUSIONS : Considering both safety and efficacy , AMR at a dose of 35 mg / m(2 ) with routine prophylactic use of G - CSF may be more desirable for the treatment of relapsed SCLC in clinical practice . - pubmed
CO reduced acute tubular necrosis , apoptosis , tissue factor expression and P - selectin expression and enhanced proliferative repair as measured by phosphorylation of retinol binding protein and histone H3 . - pubmed
[ Peeling skin disease : the responsibility of corneodesmosin ] . - pubmed
Other systemic viruses may cause hepatic injury that can range from mild and transient elevation of aminotransferases to acute hepatitis and occasionally acute liver failure and fulminant hepatitis . - pubmed
Class II - associated invariant chain peptide expression represents a novel parameter for flow cytometric detection of acute promyelocytic leukemia . - pubmed
Previously , we showed the clinical and functional impact of class II - associated invariant chain peptide ( CLIP ) in acute myeloid leukemia ( AML ) . - pubmed
This study focuses on the analysis of CLIP expression on leukemic cells to characterize HLA - DR - negative AML , including APL . - pubmed
We demonstrate exclusive and significant CLIP expression in all cases of typical and variant APL , as compared to other HLA - DR - negative non - APL - type AML . - pubmed
Hypoxia promotes rabbit pulmonary artery smooth muscle cells proliferation through a 15 - LOX-2 product 15 ( S )- hydroxyeicosatetraenoic acid . - pubmed
We found that hypoxia enhances 15 - lipoxygenase-2 ( 15 - LOX-2 ) expression and stimulates cultured rabbit PASMCs proliferation . - pubmed
Hypoxia ( 3 % O ( 2 ))-stimulated PASMC proliferation was blocked by U0126 , a MEK inhibitor , as well as by NDGA and CDC , inhibitors of 15 - LOX , but not by the p38 MAPK inhibitor SB-202190 . - pubmed
We conclude that 15 - LOX-2 and its product , 15 ( S )- HETE , are important intermediates in hypoxia - induced rabbit PASMC proliferation and may participate in hypoxia - induced pulmonary hypertension . - pubmed
Paraneoplastic syndrome in mice bearing high - angiogenic variant of Lewis lung carcinoma : relations with tumor derived VEGF . - pubmed
CONCLUSION : Manifestation of the paraneoplastic hematological syndrome most likely is conditioned on the ability of cancer cell to secrete VEGF in a high rate . - pubmed
Helminth antigens enable CpG - activated dendritic cells to inhibit the symptoms of collagen - induced arthritis through Foxp3 + regulatory T cells . - pubmed
Vaccination of mice with CII pulsed T / C - DC diminished the severity and incidence of CIA symptoms and the production of the inflammatory cytokine , while induced the production of anti - inflammatory cytokines . - pubmed
Vaccination with CII pulsed T / C - DC seems to be a very efficient approach to diminish exacerbated immune response in CIA , by inducing the development of Treg cells , and it is therefore an interesting candidate for a cell - based therapy for rheumatoid arthritis ( RA ) . - pubmed
Conversely , there is emerging evidence that other T cell subsets ( gammadelta , gammadelta ) , CD8(+ ) T cells and natural killer ( NK ) cells may play a vital role in immune protection against Mtb infection and BCG - induced immune protection . - pubmed
In this paper , the controversy over the role of IFN - gamma as a marker for protective immunity against TB , and emerging data on the role of gammadelta T cells , CD8(+ ) and NK cells in TB immunology , will be presented . - pubmed
In a multivariate COX analysis age , WHO performance score , subcortical localization , extent of surgery , radiation treatment , chemotherapy , and the presence of large necrosis had individual effect on overall survival ( p & lt ; 0.05 ) . - pubmed
BACKGROUND : Although many Asian type 2 diabetic patients have been considered to be not obese and have low capacity of insulin secretion , the proportion of obese patients with visceral fat accumulation has increased in recent years . - pubmed
Podoplanin expression in cancer - associated fibroblasts correlates with VEGF - C expression in cancer cells of invasive ductal breast carcinoma . - pubmed
Podoplanin ( D2 - 40 ) was shown to be expressed in cancer - associated fibroblasts ( CAFs ) of various malignancies . - pubmed
Podoplanin expression in CAFs correlated positively with cancer cell VEGF - C expression ( r=0.19 , p=0.0495 ) and intratumoral microvessel count ( MVC ) of CD31 positive vessels ( r=0.30 , p=0.0018 ) , whereas negative correlations were observed with peritumoral MVC of D2 - 40 and Lyve-1 positive lymphatic vessels ( r=-0.26 , p=0.008 and r=-0.27 , p=0.0058 , respectively ) . - pubmed
Podoplanin expression in CAFs did not correlate with VEGF - A and VEGF - D expression in cancer cells , nor exerted any prognostic significance . - pubmed
Podoplanin expression in CAFs may have impact on angio- and lymphangiogenesis processes in IDC . - pubmed
Activating mutations in c - Kit lead to alteration of these cellular processes and have been implicated in many human cancers such as gastrointestinal stromal tumors , acute myeloid leukemia , testicular seminomas and mastocytosis . - pubmed
[ Changes in CD4(+)CD25(+ ) regulatory T cells in patients with spontaneous subarachnoid hemorrhage ] . - pubmed
OBJECTIVE : To explore the role of CD4(+)CD25(+ ) regulatory T cells ( Treg ) in the occurrence of spontaneous subarachnoid hemorrhage ( SAH ) . - pubmed
METHODS : Fifteen patients with spontaneous SAH , 15 with traumatic SAH , and 15 with headache without organic pathologies as confirmed by lumbar puncture ( control group ) were examined with flow cytometry for Treg in the peripheral blood and cerebrospinal fluid and intracellular cytokine interleukin-10 ( IL-10 ) and transforming growth factor beta1 ( TGF - beta1 ) levels . - pubmed
RESULTS : Spontaneous SAH patients showed significantly lowered peripheral blood Treg , IL-10 , and TGF - beta1 in the cerebrospinal fluid compared with the patients with traumatic SAH and the control group ( P<0.05 ) , and the 3 measurements were comparable between the latter two groups ( P>0.05 ) . - pubmed
Correlation analysis showed that Treg , IL-10 and TGF - beta1 were all inversely correlated with NIHSS , VAS , and duration of hospitalization but positively correlated with GCS ( the absolute r values were all greater than 0.6 , P<0.05 ) . - pubmed
OBJECTIVE : This study was undertaken in the belief that the atypical antipsychotic drug quetiapine could prevent apoptosis in the penumbra region following ischemia , taking into account findings that show 5 - hydroxytryptamine-2 receptor blockers can prevent apoptosis . - pubmed
DNA MET % was measured as incorporation of [ ( 3 ) H ] dCTP following HpaII cut in 96 ALS patients and 87 controls , comprising : early - onset ( < 55 years of age ) and late - onset ( > 74 years of age ) . - pubmed
In conclusion , increased DNA MET % is a possible marker of epigenetic dysfunction in ALS independently of age of onset . - pubmed
Osteopontin is a promoter for hepatocellular carcinoma metastasis : a summary of 10 years of studies . - pubmed
In our previous gene expression profiling study , OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma ( HCC ) . - pubmed
We focused on OPN to evaluate its prognostic values and important roles in HCC metastasis . - pubmed
A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of the leading independent prognostic factors for HCC patients , even in the early stage of HCC , and could serve as a surrogate serologic biomarker for monitoring the treatment response and tumor recurrence after HCC resection . - pubmed
Using both in vitro and in vivo investigations , we found that OPN has an important role in metastasis and tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis . - pubmed
We also found that OPN+ HCC cells have much more amplifications at chromosomal regions , and promoter polymorphisms are important in the regulation of OPN expression and tumor growth and lung metastasis of HCC . - pubmed
Electrocardiogram , ultrasonic cardiogram , arrhythmia , troponin and non - hematologic toxicity were recorded and compared after the second , forth and sixth cycle of chemotherapy . - pubmed
The reduction of QRS voltage , arrhythmia and abnormal troponin were 55.0 % , 45.0 % and 45.0 % , respectively , in the control group , significantly higher than those in the experimental group ( 20.0 % , P & lt ; 0.05 ) , ( 10.0 % , P = 0.010 ) and ( 10.0 % , P & lt ; 0.05 ) , respectively . - pubmed
Treatments addressing both at the same time might have advantages over more specific approaches , such as vascular endothelial growth factor ( VEGF ) inhibitors , which are used to treat vascular leak but are suspected to have a neurotoxic effect . - pubmed
TA not only prevented the development of retinal vascular lesions but also inhibited fluorescein leakage from established vascular lesions . - pubmed
Our results corroborate previous findings reporting the involvement of DRD3 receptor in addictions . - pubmed
Successful engraftment of third allogeneic hematopoietic stem cell transplantation after two graft failures and treatment for anti - HLA antibody in a pediatric acquired aplastic anemia patient . - pubmed
Here , we exploit the availability of genome sequences for Hpa and Arabidopsis to measure gene - expression changes in both Hpa and Arabidopsis simultaneously during infection . - pubmed
Using a high - throughput cDNA tag sequencing method , we reveal expression patterns of Hpa predicted effectors and Arabidopsis genes in compatible and incompatible interactions , and promoter elements associated with Hpa genes expressed during infection . - pubmed
Finally , we found a highly - expressed Hpa effector candidate that suppresses responsiveness to SA . - pubmed
Skin lesions after oral acetylcholinesterase inhibitor therapy : a case report . - pubmed
A series of botulism challenge studies were conducted to determine if botulinum toxin would be produced in mussels ( Mytilus edulis ) inoculated with non - proteolytic Clostridium botulinum spores and held under modified atmosphere ( MA ) packaging conditions at normal ( 4 C ) and abusive ( 12 C ) temperatures . - pubmed
After adjusting for gender , age , systolic blood pressure , serum albumin , calcium - phosphorus product , hemoglobin A1c , and use of an angiotensin - converting enzyme inhibitor or an angiotensin II receptor blocker , patients with nephrotic range proteinuria showed a 3.89 - fold ( 95 % CI 1.08 - 14.5 ) increased risk for rapid renal function decline defined as a decline in eGFR & gt;=0.5 ml / min/1.73 m(2 ) per month . - pubmed
Toll - like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia - reperfusion in the mouse . - pubmed
We therefore evaluated the role of TLR5 , expressed at high level in the heart , in the development of myocardial damage and inflammation acutely triggered by MIR . - pubmed
TLR5(-/- ) and wild - type ( WT ) mice were exposed to MIR ( 30 min ischaemia , 2 h reperfusion ) . - pubmed
Lack of TLR5 fostered p38 phosphorylation , reduced AKT phosphorylation and markedly increased the expression of inflammatory cytokines , whereas it precipitated acute LV ( left ventricle ) dysfunction . - pubmed
Therefore , contrary to the detrimental roles of TLR2 , TLR3 and TLR4 in the infarcted heart , TLR5 is important to limit myocardial damage , inflammation and functional compromise after MIR . - pubmed
As islet architecture was destroyed with age in ZFDM rats , a combination of severe insulin resistance , diminished insulin secretory response to incretin , and intrinsic fragility of the islets may cause the development of T2D in this strain . - pubmed
Re : Ion Channel TRPM8 Promotes Hypoxic Growth of Prostate Cancer Cells via an O2 - Independent and RACK1 - Mediated Mechanism of HIF-1alpha Stabilization . - pubmed
A Potential Role for the Inhibition of PI3 K Signaling in Glioblastoma Therapy . - pubmed
In almost 90 % of all GBM alterations in the PI3K / Akt / mTOR have been found , making this survival cascade a promising therapeutic target , particular for combination therapy that combines an apoptosis sensitizer , such as a pharmacological inhibitor of PI3 K , with an apoptosis inducer , such as radio- or chemotherapy . - pubmed
In this study , we analyze the effects of the dual kinase inhibitor PI-103 , which blocks PI3 K and mTOR activity , on three matched pairs of GBM stem cells / differentiated cells . - pubmed
While blocking PI3K - mediated signaling has a profound effect on cellular proliferation , in contrast to data presented on two GBM cell lines ( A172 and U87 ) PI-103 actually counteracts the effect of chemotherapy . - pubmed
Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability . - pubmed
BACKGROUND : The gene expressions of netrin-1 dependence receptors , DCC and UNC5C , are frequently downregulated in many cancers . - pubmed
RESULTS : In the present study , a series of genetic and epigenetic analyses for DCC and UNC5C were performed in a Japanese cohort of 98 sporadic gastric cancers and corresponding normal gastric mucosa specimens . - pubmed
More than 5 % methylation in the DCC and UNC5C promoters were found in 45 % ( 44/98 ) and 32 % ( 31/98 ) gastric cancers , respectively , and in 9 % ( 9/105 ) and 5 % ( 5/105 ) normal gastric mucosa , respectively . - pubmed
Overall , 70 % ( 58 of 83 informative cases ) and 51 % ( 40 of 79 informative cases ) of gastric cancers harbored either LOH or aberrant methylation in the DCC and UNC5C genes , respectively . - pubmed
Both DCC and UNC5C were inactivated in 97 % of CIN - positive gastric cancers and in 55 % of CIN - negative gastric cancers . - pubmed
CONCLUSIONS : Defect in netrin receptors is a common feature in gastric cancers . - pubmed
DCC alterations are apparent in the early stages , and UNC5C alterations escalate with the progression of the disease , suggesting that the cumulative alterations of netrin-1 receptors was a late event in gastric cancer progression and emphasizing the importance of this growth regulatory pathway in gastric carcinogenesis . - pubmed
We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis ( MTB ) antigens in individuals latently infected with MTB ( LTBI ) , and uninfected individuals with previous BCG vaccination , from nine locations and populations with different HLA distribution , MTB exposure rates , and standards of TB care . - pubmed
Targeting Interleukin-1beta Reduces Leukocyte Production After Acute Myocardial Infarction . - pubmed
METHODS AND RESULTS : With the use of parabiosis surgery , this study shows that soluble danger signals , among them interleukin-1beta , increase bone marrow hematopoietic stem cell proliferation after MI . - pubmed
Anti - interleukin-1beta treatment dampens the post - MI increase in hematopoietic stem cell proliferation . - pubmed
Consequently , decreased leukocyte numbers in the blood and infarct reduce inflammation and diminish post - MI heart failure in ApoE(-/- ) mice with atherosclerosis . - pubmed
Prognostic significance of FAM83D gene expression across human cancer types . - pubmed
The family with sequence similarity 83 , member D ( FAM83D ) gene has been proposed as a new prognostic marker for breast cancer . - pubmed
Here we further evaluate the prognostic significance of FAM83D expression in different breast cancer subtypes using a meta - analysis . - pubmed
Patients with higher FAM83D mRNA levels have significantly decreased overall and metastatic relapse - free survival , particularly in the group of patients with ER - positive , or luminal subtype tumors . - pubmed
We also assessed FAM83D alterations and its prognostic significance across 22 human cancer types using The Cancer Genome Atlas ( TCGA ) . - pubmed
FAM83D is frequently gained in the majority of human cancer types , resulting in the elevated expression of FAM83D. - pubmed
Higher levels of FAM83D mRNA expression are significantly associated with decreased overall survival in several cancer types . - pubmed
Finally , we demonstrate that TP53 mutation in human cancers is coupled to a significant increase in the expression of FAM83D , and that a higher level of FAM83D expression is positively correlated with an increase in genome instability in many cancer types . - pubmed
These results identify FAM83D as a potential novel oncogene across multiple human cancer types . - pubmed
Neuroscience - informed Auditory Training in Schizophrenia : A Final Report of the Effects on Cognition and Serum Brain - Derived Neurotrophic Factor . - pubmed
At baseline , schizophrenia participants had significantly lower - than - normal serum BDNF . - pubmed
FGF23 in chronic kidney disease : are we lost in translation ? - pubmed
Flap endonuclease 1 polymorphisms ( rs174538 and rs4246215 ) contribute to an increased cancer risk : Evidence from a meta - analysis . - pubmed
Since the identification of functional polymorphisms of FEN1 ( rs174538 and rs4246215 ) , numerous studies have evaluated the association between the two single - nucleotide polymorphisms and cancer risk . - pubmed
To derive a more precise estimation , a meta - analysis was performed on the association between the FEN1 polymorphisms ( rs174538 and rs4246215 ) and cancer risk . - pubmed
The present meta - analysis indicated that FEN1 rs174538 and rs4246215 polymorphisms may contribute to an increased risk of cancer . - pubmed
Expression of different cytokines and growth factors after myocardial injury has been associated with fibroplasia and dilatation versus reverse remodeling and myocardial repair . - pubmed
Specifically , the proinflammatory / fibrotic mediators : interleukin ( IL )- 6 , epidermal growth factor , and fibroblast growth factor ( FGF )- 2 cause fibroplasia , whereas reparative cytokines including : IL-1alpha , IL-1beta , IL-4 , and IL-13 can limit fibrosis . - pubmed
Donor CD4(+ ) T and B cells play important roles in cGVHD pathogenesis , but the role of antibodies from donor B cells remains unclear . - pubmed
In contrast , IgH(microgamma1 ) grafts induced only transient cGVHD with little damage in the thymus or peripheral lymph organs or with little cutaneous Th17 infiltration . - pubmed
Injections of IgG - containing sera from cGVHD recipients given WT grafts but not IgG - deficient sera from recipients given IgH(microgamma1 ) grafts led to deposition of IgG in the thymus and skin , with resulting damage in the thymus and peripheral lymph organs , cutaneous Th17 infiltration , and perpetuation of cGVHD in recipients given IgH(microgamma1 ) grafts . - pubmed
These results indicate that donor B - cell antibodies augment cutaneous cGVHD in part by damaging the thymus and increasing tissue infiltration of pathogenic Th17 cells . - pubmed
The regulatory role of interferon - gamma producing gamma delta T cells via the suppression of T helper 17 cell activity in bleomycin - induced pulmonary fibrosis . - pubmed
Histological and biochemical analyses showed that bleomycin - induced IP was more severe in T cell receptor ( TCR - delta - deficient ( TCRdelta (-/- ) ) mice than WT mice . - pubmed
The examination of IL-17A (-/- ) TCRdelta (-/- ) mice indicated that gammadeltaT cells suppressed pulmonary fibrosis through the suppression of IL-17A(+ ) CD4(+ ) T cells . - pubmed
Pulmonary fibrosis was attenuated by IFN - gamma - producing gammadeltaT cells through the suppression of pulmonary IL-17A(+ ) CD4(+ ) T cells . - pubmed
CD4(+)CD25(+)CD127(- ) and CD4(+)CD25(+)Foxp3(+ ) Regulatory T Cell Subsets in Mediating Autoimmune Reactivity in Systemic Lupus Erythematosus Patients . - pubmed
Introduction of the CD4(+)CD25(+)CD127(- ) and CD4(+)CD25(+)Foxp3(+ ) regulatory subpopulations analysis into immunological processes assessment and disease activation prognosis in patients with lupus nephritis ( LN ) may improve monitoring of disease activity and enable an early , and thus more effective , therapeutic treatment . - pubmed
IN CONCLUSION : ( 1 ) reduction in the number of regulatory CD4(+)CD25(+)Foxp3(+ ) cells is a promising indicator of the activity of SLE , particularly of renal involvement ; ( 2 ) determination of the number of regulatory cells using the CD4(+)CD25(+)CD127(- ) phenotype is unreliable in patients with SLE . - pubmed
CD40L expression by CD4 + but not CD8 + T cells regulates antiviral immune responses in acute LCMV infection in mice . - pubmed
However , deficiency of CD40L in CD8 + T cells did influence neither the quantity nor the quality of primary T - cell responses in LCMV infection . - pubmed
Thus , our results unambiguously demonstrate that while CD40L is critical to generate effective primary CD8 + T - cell responses also under inflammatory conditions , CD40L expression by CD8 + T cells themselves is dispensable in acute LCMV infection . - pubmed
Compared with JLPS cells , the increased glucose uptake in JLPR cells ( with upregulated glucose transporters , increased antioxidant enzyme activity , and altered cell cycling ) conferred ascorbate - induced cytotoxicity and resistance . - pubmed
Here we describe the addition of KSHV proteins LANA and K8.1 to a previously evaluated HIV / co - infection multiplexed fluorescence immunoassay system . - pubmed
These results demonstrate good sensitivity and specificity for detection of antibody to KSHV antigens , and demonstrate the potential for multiplexed co - infection testing in resource - limited settings to identify those at increased risk for HIV-1 - related complications . - pubmed
In particular , 60 breast cancers with the following four molecular subtypes were analyzed : luminal A , luminal B , human epidermal growth factor receptor-2 ( HER2)-over - expressing and basal - like . - pubmed
These results indicate that EV Ag delivery via DNA vaccination offers a new strategy for eliciting strong CD8 + T cell responses to the encoded Ag , making it a potentially useful cancer vaccine . - pubmed
Lecithin : cholesterol acyltransferase ( LCAT ) catalyzes plasma cholesteryl ester formation and is defective in familial lecithin : cholesterol acyltransferase deficiency ( FLD ) , an autosomal recessive disorder characterized by low high - density lipoprotein , anemia , and renal disease . - pubmed
Eligibility for alirocumab or evolocumab treatment in 1090 hypercholesterolemic patients referred to a regional cholesterol treatment center with LDL cholesterol & gt;=70 mg / dL despite maximal - tolerated LDL - cholesterol - lowering therapy . - pubmed
BACKGROUND : Proprotein convertase subtilisin / kexin type 9 inhibitors , Praluent ( alirocumab [ ALI ] ) and Repatha ( evolocumab [ EVO ] ) have been approved as adjuncts to the standard - of - care maximal - tolerated dose ( MTD ) of low - density lipoprotein cholesterol ( LDLC)-lowering therapy ( LLT ) , statin therapy , in heterozygous ( HeFH ) ( ALI or EVO ) or homozygous ( EVO ) familial hypercholesterolemia , or clinical atherosclerotic cardiovascular disease ( CVD ) where LDLC lowering is insufficient ( both ) . - pubmed
Recent findings have shown that the autoantibodies anti - TIF1gamma , anti - NXP2 and anti - HMGCR are associated with cancers in the course of myositis . - pubmed
Effect of neprilysin inhibition on renal function in patients with type 2 diabetes and chronic heart failure who are receiving target doses of inhibitors of the renin - angiotensin system : a secondary analysis of the PARADIGM - HF trial . - pubmed
BACKGROUND : Neprilysin inhibition has favourable effects on experimental diabetic nephropathy . - pubmed
We sought to assess the effects of neprilysin inhibition on the course of renal function in patients with type 2 diabetes . - pubmed
The greater effect of neprilysin inhibition in patients with diabetes could not be explained by the effects of treatment on the course of heart failure or on HbA1c . - pubmed
INTERPRETATION : In patients in whom the renin - angiotensin system is already maximally blocked , the addition of neprilysin inhibition attenuates the effect of diabetes to accelerate the deterioration of renal function that occurs in patients with chronic heart failure . - pubmed
YAP plays a central role in organ size control , and its deregulation strongly promotes cancer initiation and progression . - pubmed
Here , we report that YAP induces leukocyte - specific integrin beta2 ( ITGB2 ) expression in cancer cells , thereby promoting cell invasion through the endothelium in a manner mimicking leukocytes . - pubmed
Consistently , ITGB2 and PRDM4 mRNA levels are significantly increased in metastatic prostate cancer . - pubmed
GCS secretes the hemolysis toxin ( streptolysin S , SLS ) that causes hemolysis in the host cells . - pubmed
Berberine Attenuates Macrophages Infiltration in Intracranial Aneurysms Potentially Through FAK / Grp78 / UPR Axis . - pubmed
Methods and Results : Human aneurysm tissues were collected by microsurgical clipping and immunostained for phospho - Focal adhesion kinase ( FAK ) and CD68 + macrophages . - pubmed
Immunostaining data showed that BBR inhibited CD68 + macrophages accumulation in IAs tissues and suppressed FAK phosphorylation . - pubmed
Conclusion : BBR prevents IAs formation potentially through inhibiting FAK phosphorylation and inactivating UPR pathway in macrophages , which causes less macrophage infiltration and reduced proinflammatory cytokine release . - pubmed
The biological indicators of Qi deficiency related were blood lipids , ECG , blood rheology , inflammatory reaction , NO , ET and NF - kappaB signalling pathway . - pubmed
These findings indicated that GBP-1 might play a crucial role in barrier function of normal human salivary gland duct epithelium and perform a preventive role in the duct epithelium of IgG4 - RD disease . - pubmed
Leucocyte esterase strips are available for identifying leucocyte esterase activity in urine and other body fluids which suggest inflammation . - pubmed
Aim : To compare the diagnostic ability of the leucocyte esterase test between pyogenic meningitis and CSF contaminated with circulating neutrophils . - pubmed
Materials and Methods : The CSF samples of pyogenic meningitis patients were analyzed for leucocyte esterase activity . - pubmed
Conclusion : Leucocyte esterase strip is specific for pyogenic meningitis ( activated neutrophils ) , and hence can differentiate from CSF contaminated with blood . - pubmed
MicroRNA-26a reduces synovial inflammation and cartilage injury in osteoarthritis of knee joints through impairing the NF - kappaB signaling pathway . - pubmed
Herein , the present study explored the effect of microRNA-26a ( miR-26a ) on the synovial inflammation and cartilage injury in OA , with the involvement with the NF - kappaB signaling pathway . - pubmed
Methods : Rat models of OA were established by anterior cruciate ligament transection , which were then treated with miR-26a mimics / inhibitors or BMS-345541 ( inhibitor of NF - kappaB pathway ) . - pubmed
Results : Poorly expressed miR-26a and increased protein levels of P - IkappaBalpha and P - P65 were identified in synovial tissues of OA rats . - pubmed
In response to miR-26a mimics , protein levels of P - IkappaBalpha and P - P65 were reduced ; meanwhile , synovial tissue hyperplasia , inflammation and cartilage injury of femoral condyle were ameliorated , with decreased inflammation and cartilage injury scores , and apoptosis of synoviocytes and chondrocytes . - pubmed
Conclusion : MiR-26a suppressed the activation of the NF - kappaB signaling pathway , by which mechanism the synovial inflammation and cartilage injury in OA rats were alleviated . - pubmed
The role of disordered angiogenesis tissue markers ( sflt-1 , Plgf ) in present day diagnosis of preeclampsia . - pubmed
According to present data , sFlt-1 , PlGF and the sFlt-1 / PlGF ratio are very useful tools in assessing placental angiogenesis abnormalities associated with preeclampsia and can be use in clinical practice . - pubmed
lucidum extracts were then evaluated using SAMP8 and APP / PS1 AD model mice by whole genome bisulfite sequencing , and some methylation regulators including Histone H3 , DNMT3A , and DNMT3B in brain tissues were up - regulated after treatment with alcohol extracts from G. - pubmed
lucidum alcohol extracts could improve learning and memory function , ameliorate neuronal apoptosis and brain atrophy , and down - regulate the expression of the AD intracellular marker , Abeta1 - 42 . - pubmed
We found a subset of MDR inhibitors also induced IEC delamination , implicating MDR efflux pumps as cellular targets underlying Glafenine - induced enteropathy . - pubmed
IL-1beta Blockade Attenuates Thrombosis in a Neutrophil Extracellular Trap - Dependent Breast Cancer Model . - pubmed
Interleukin-1beta ( IL-1beta ) modulates the expression of granulocyte colony - stimulating factor ( G - CSF ) , a cytokine that promotes cancer - associated neutrophilia and NET generation . - pubmed
Herein , we combined a murine breast cancer model with a flow - restriction thrombosis model to evaluate whether the IL-1beta blockade could interfere with cancer - associated thrombosis . - pubmed
Mice bearing metastatic 4T1 tumors exhibited high neutrophil counts as well as elevated expression of G - CSF and IL-1beta in their tumors . - pubmed
On the other hand , mice bearing non - metastatic 67NR tumors showed no elevation in neutrophil counts and displayed low expression levels of G - CSF and IL-1beta in their tumors . - pubmed
Pharmacological blockade of IL-1 receptor ( IL-1R ) decreased the primary growth of 4T1 tumors and reduced the systemic levels of myeloperoxidase , cell - free DNA ( cfDNA ) and G - CSF , without interfering with the neutrophil counts . - pubmed
Most remarkably , the blockade of IL-1R abolished the prothrombotic state observed in 4T1 tumor - bearing mice . - pubmed
Overall , our results demonstrate that IL-1beta might be a feasible target to attenuate cancer - associated thrombosis , particularly in cancer types that rely on increased G - CSF production and involvement of NET formation . - pubmed
Accumulated evidence has shown the protective effects of S1P receptor modulators on MS and its animal model , experimental autoimmune encephalomyelitis ( EAE ) . - pubmed
Here we demonstrate that MAT alleviated astrogliosis in the CNS of EAE rats , and downregulated levels of SPH , S1P and S1P1 expression in CNS tissues and astrocytes . - pubmed
These findings indicate that MAT could alleviate astrogliosis in EAE through diminishing the SPH / SPHK / S1P1 pathway . - pubmed
We aimed to evaluate the effects of the angiotensin receptor blocker losartan on gut microbiota in spontaneously hypertensive rats ( SHR ) , and to test if this modification contributes to its blood pressure ( BP ) reducing properties . - pubmed
The branched - chain amino acids ( BCAA ) play an important role in muscle energy metabolism , and Kruppel - like factor 15 ( KLF15 ) is an essential regulator of BCAA metabolism in muscle under nutritional deficiency . - pubmed
The above results indicated that the regulatory role of KLF15 in BCAA catabolism of muscle in Chinese soft - shelled turtles under nutritional deficiency , which might be activated the catabolism of BCAA in muscle to provide energy and maintain the homeostasis by KLF15 - BACC signaling axis . - pubmed
Total follicle diameter , BMI , PCOS and AMH were additional determinants of circulating prorenin . - pubmed
CONCLUSIONS : CL number , IVF protocol , BMI , PCOS and AMH affect maternal RAAS activation in early pregnancy , and may thus contribute to pregnancy complications . - pubmed
IgG4 - related hypophysitis diagnosed by retroperitoneal mass biopsy in a patient presenting with abducens nerve palsy : A case report ( CARE - compliant article ) . - pubmed
CONCLUSION : Based on the diagnosis of IgG4 - related disease in the retroperitoneal organ and response to corticosteroid treatment , this patient was diagnosed with IgG4 - related hypophysitis . - pubmed
When IgG4 - related hypophysitis is suspected , a thorough examination of other organ lesions and biopsy should be considered . - pubmed
A novel homozygous variant in REN in a family presenting with classic features of disorders involving the renin - angiotensin pathway , without renal tubular dysgenesis . - pubmed
Autosomal recessively inherited pathogenic variants in genes associated with the renin - angiotensin - aldosterone system ( RAAS ) result in early onset oligohydramnios and clinical features of the Potter sequence , typically in association with proximal renal tubules dysgenesis . - pubmed
To our knowledge , this is the first identification of an association between biallelic variants in REN and oligohydramnios in the absence of renal tubular dysgenesis . - pubmed
Due to its role in the RAAS , it has previously been proposed that the decreased expression of REN results in hypotension , ischemia , and decreased urine production . - pubmed
We suggest sequencing of genes in the RAAS , including REN , should be considered in cases of severe early onset oligohydramnios , even when renal morphology and histology are normal . - pubmed
Long non - coding RNAs ( lncRNAs ) are considered regulators of autophagy , and the aim of the present study was to investigate the prognostic value of autophagy - related lncRNA ( ARlncRNA ) and develop a new prognostic signature to predict the 1 - year and 3 - year overall survival ( OS ) of HCC patients . - pubmed
B7 - H3 - Induced Signaling in Lung Adenocarcinoma Cell Lines with Divergent Epidermal Growth Factor Receptor Mutation Patterns . - pubmed
B7 - H3 - induced signaling includes at least three cascades : PI3K / AKT , JAK2 / STAT3 , and Raf / MEK / ERK1 / 2 , which are also involved in epidermal growth factor receptor- ( EGFR- ) triggered signaling in lung adenocarcinoma cells . - pubmed
However , the correlation between B7 - H3 - induced signaling and EGFR signaling , and between B7 - H3 - targeted immunotherapy and EGFR - targeted therapy in lung adenocarcinoma , remains to be elucidated . - pubmed
Herein we find that knockout of B7 - H3 gene decreased cell survival and increased EGFR - tyrosine kinase inhibitor gefitinib susceptibility of both H3255 and HCC827 cells , two lung adenocarcinoma cell lines harboring EGFR L858R ( exon 21 ) and Del E746 - A750 ( exon 19 ) mutations , respectively . - pubmed
Collectively , our study reveals B7 - H3 - induced signaling in lung adenocarcinoma cell lines with divergent EGFR mutations , and a translational potential of combined targeted therapy of B7 - H3 and EGFR in lung adenocarcinoma with EGFR Del E746 - A750 mutation . - pubmed
In Friend leukemia and NIH 3T3 cells , the levels of gas5 gene mRNA were high in saturation density - arrested cells and almost undetectable in actively growing cells . - pubmed
Comparison of spinal fluid beta 2 - microglobulin levels with CD4 + T cell count , in vitro T helper cell function , and spinal fluid IgG parameters in 163 neurologically normal adults infected with the human immunodeficiency virus type 1 . - pubmed
Beta 2 - microglobulin levels were measured in the cerebrospinal fluid ( CSF ) and serum of 163 human immunodeficiency virus - positive ( HIV+ ) persons with normal neurologic physical examinations . - pubmed
CSF beta 2 - microglobulin concentration may serve as a marker for subclinical neurologic damage due to HIV . - pubmed
The thrombus can be lysed and blood flow can be restored with intravenous agents that activate plasminogen . - pubmed
Intravenous rt - PA , a relatively fibrin - specific agent , elicits recanalization in 70 to 75 per cent of infarct - related arteries . - pubmed
Compared with those not so affected , hirsutism was associated with a higher mean serum testosterone concentration , infertility was associated with higher mean gonadotrophin concentrations , obesity was associated with a higher mean serum testosterone concentration , hyperprolactinaemia was associated with a lower mean serum testosterone concentration and smaller ovaries , alopecia was associated with lower mean serum LH and testosterone concentrations , and acanthosis nigricans was associated with obesity and a raised mean serum testosterone concentration . - pubmed
coli mutant have provided evidence suggesting an involvement of a topoisomerase activity in DNA double - strand break mis - repair , which may be relevant to the biochemical defect in A - T. - pubmed
A 58 - year - old white man presented with severe progressive proximal motor neuropathy , dermato - endocrine changes , and an IgG kappa paraprotein . - pubmed
Over a 2 1/2 - year period , treatment with melphalan and prednisolone produced improvement in the neuropathy and resolution of dermato - endocrine features with a corresponding decline in the serum paraprotein concentration . - pubmed
These responses and possible reasons for the increased radiosensitivity of xrs mutants are discussed and compared to ataxia telangiectasia ( A - T ) cells and a radiosensitive mutant mouse lymphoma cell line . - pubmed
The effect of Ehrlich ascites tumour growth on lactate dehydrogenase activities in tissues and physiological fluids of tumour bearing mice . - pubmed
In order to investigate the hormone dependency of gastric cancer , the presence of estrogen receptor ( E.R. ) - pubmed
In addition , treatment with this analog abolished the pituitary hypertrophy and LH hypersecretion normally associated with castration . - pubmed
Primary autoimmune hypothyroidism was confirmed by the finding of a low serum thyroxine concentration and a high thyrotropin concentration . - pubmed
The inhibitor found in this patient may have been specific for factor VIII , but the presence of coagulation inhibitors should be considered in patients with hypothyroidism . - pubmed
Serum and blister fluid immune complexes in bullous pemphigoid : detection with C1q and monoclonal rheumatoid factor . - pubmed
Eighty serum samples and 24 blister fluids from 51 patients with active bullous pemphigoid were tested for the presence of immune complexes by both a monoclonal rheumatoid factor ( mRF ) inhibition radioassay and a C1q - binding radioassay . - pubmed
Mechanism of protein C deficiency in a patient with arginine 358 alpha 1 - antitrypsin ( Pittsburgh mutation ): role in the maintenance of hemostatic balance . - pubmed
In comparison with subjects with good LC , patients with poor LC had higher values of duration of DM ( p & lt ; 0.01 ) , waist / hip ratio ( p & lt ; 0.04 ) , fasting glucose ( p & lt ; 0.001 ) and lower values of fasting insulin ( p & lt ; 0.07 ) , LDL cholesterol ( p & lt ; 0.006 ) and VLDL cholesterol ( p & lt ; 0.09). - pubmed
These data indicate that endogenous adenosine inhibits renin release during hemorrhagic hypotension , but does not attenuate noradrenergic neurotransmission even during prolonged hemorrhagic hypotension . - pubmed
Finally , these experiments indicate that hemorrhagic hypotension can enhance noradrenergic neurotransmission by a mechanism that does not involve the renal renin - angiotensin system . - pubmed
These results provide strong evidence for an autocrine IL-8 synthesis and for an IL-8 - dependent proliferation in a subgroup of human melanomas . - pubmed
Furthermore , they suggest that IL-8 may play a role not only in immunomodulation but also in melanoma progression and metastatic spread . - pubmed
A greater production of beta A4 was observed in persons with inherited forms of Alzheimer ' s disease . - pubmed
The infection of epithelia ] swine testicle and intestinal porcine epithelial ( IPEC-1 ) cell lines by adenovirus type 5 ( Ad5 ) has been studied in vitro by using an Ad5 - luciferase recombinant containing the firefly luciferase gene as a reporter . - pubmed
Carboplatin - induced emesis is observed in about 40 % of patients despite anti - emetic prophylaxis with 5 - HT3 antagonists . - pubmed
5 - HT3 receptor antagonists such as ondansetron seem to be efficacious both in the control of acute and prolonged emesis following carboplatin chemotherapy , but randomly controlled data comparing ondansetron with other anti - emetic regimens have not yet been published . - pubmed
The induction of prostaglandin G / H synthase ( PGHS ; prostaglandin endoperoxide synthase , cyclooxygenase ) by proinflammatory cytokines accounts , at least in part , for the altered eicosanoid biosynthesis in inflammatory diseases . - pubmed
In vivo efficacy and toxicity of a single - chain immunotoxin targeted to CD40 . - pubmed
G28 - 5 sFv - PE40 is a single - chain immunotoxin targeted to CD40 , which is highly expressed on human hematologic malignancies , including non - Hodgkin ' s lymphoma , B - lineage leukemias , multiple myeloma , and Hodgkin ' s disease , as well as certain carcinomas . - pubmed
In summary , G28 - 5 sFv - PE40 was effective at inducing complete antitumor responses in lymphoma xenografted mice at doses that were well tolerated in mice , rats , and monkeys . - pubmed
Special stains revealed focal intracytoplasmic mucin accumulation , and immunohistochemistry showed the tumors to be positive for CAM 5.2 , CEA , chromogranin A , and calcitonin . - pubmed
The three tumors exhibited positive staining with D07 ( anti - p53 ) , and flow cytometric analysis revealed DNA aneuploidy and polyploidy . - pubmed
Further study is necessary to determine whether mutation of the p53 gene is important in the evolution of laryngeal neuroendocrine tumors and whether DNA aneuploidy or polyploidy identifies a subset of these tumors with a poor prognosis . - pubmed
Role of tumor necrosis factor alpha in the host response of mice to bacteremia caused by pneumolysin - deficient Streptococcus pneumoniae . - pubmed
These studies show that the host resistance developed during the first 1 to 2 days after infection with a pneumolysin - deficient mutant strain is dependent on tumor necrosis factor alpha but is apparently independent of interleukin 1beta ( IL-1beta ) or IL-6 . - pubmed
The change in protein dynamics detected in these experiments could be the molecular basis for the alteration of keratin IF organization in alcoholic hepatitis . - pubmed
To further corroborate the combination effects of BAY X 1005 and dexamethasone the 5 - HT receptor antagonist methysergide and the H1 receptor antagonist pyrilamine were employed as a pretreatment to eliminate mouse - specific inflammation responses . - pubmed
TNF - mediated cytotoxicity and activation of caspase-3 were both abrogated in gamma - GCS - overexpressing cells . - pubmed
Interaction between insulin resistance and factor XIII Val34Leu in patients with coronary artery disease . - pubmed
Latent antithrombin , an inactive antithrombin form with low heparin affinity , has previously been shown to efficiently inhibit angiogenesis and tumor growth . - pubmed
CK - MB , cTnI and cTnT were equally efficient for the diagnosis of acute myocardial infarction , irrespective of the final diagnostic criteria used . - pubmed
Both cTnI and cTnT were of equal efficiency in the identification of a high - risk subgroup of patients with unstable angina . - pubmed
Respiratory abnormalities have been described in MASH-1 ( mammalian achaete - scute homologous gene ) and c - RET ( " rearranged during transfection " ) mutant newborn mice . - pubmed
Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients : revisited by analyzing two SNP sites ( -123 and -88 ) in vivo and in vitro . - pubmed
We have previously reported a single nucleotide polymorphism ( SNP ) at nucleotide ( nt ) position -88 ( G or T ) within an interferon - stimulated response element - like sequence in the promoter region of the MxA gene , which correlated with responsiveness of hepatitis C patients to interferon . - pubmed
WS type 2 is associated with mutations in the gene encoding microphthalmia - associated transcription factor ( MITF ) that is required for melanocyte differentiation . - pubmed
The MITF - M distal enhancer ( MDE ) , thus identified , contains the binding sites for SOX10 , a transcription factor responsible for another type of WS , known as Waardenburg - Hirschsprung syndrome . - pubmed
Autonomic regulation of experimental autoimmune encephalomyelitis : the role of interferon - gamma . - pubmed
OBJECTIVE : The effect of chemical sympathectomy on experimental autoimmune encephalomyelitis ( EAE ) was studied in interferon - gamma ( IFN - gamma ) knockout C57BL/6 mice . - pubmed
Unexpectedly , sympathectomy resulted in suppression of active EAE in IFN - gamma(-/- ) mice , implying that control of actively induced EAE by the SNS depends on INF - gamma and the integrity of the cytokine network . - pubmed
Protein expression of NF - kappaB in human colorectal adenocarcinoma . - pubmed
To clarify the role of NF - kappaB in colorectal cancer , we investigated the relationship of NF - kappaB expression by immunohistochemistry with clinicopathological variables , and other factors including apoptotic index , bcl-2 expression , p53 and K - ras mutations in 138 colorectal adenocarcinomas . - pubmed
Eighty - seven ( 63 % ) tumours showed cytoplasmic and 51 ( 37 % ) nuclear NF - kappaB expression . - pubmed
Nuclear NF - kappaB was correlated with mucinous carcinomas ( p=0.006 ) and was more apparent in the invasive margin of some tumours . - pubmed
However , NF - kappaB was not correlated with gender , age , tumour location , Dukes ' stage , survival , apoptotic index , bcl-2 expression and p53 mutations . - pubmed
Conclusively , NF - kappaB might be activated in more aggressive colorectal tumour cells , since both tumour cells in the invasive margin and the mucinous tumour cells could represent more aggressive tumour cells . - pubmed
Administration of anti - interleukin 18 antibody fails to inhibit development of dermatitis in atopic dermatitis - model mice NC / Nga . - pubmed
Previously we reported that serum IL-18 levels were elevated in the sera from atopic dermatitis - model mice NC / Nga , prior to the onset and during the development of dermatitis . - pubmed
OBJECTIVES : We studied whether neutralization of IL-18 activity might affect dermatitis in NC / Nga mice , to investigate the role of IL-18 on dermatitis . - pubmed
METHODS : NC / Nga mice were given weekly anti - IL-18 antibody starting at 5 weeks of age to 13 weeks and development of dermatitis , scratching behaviour and serum IgE concentrations were evaluated . - pubmed
RESULTS : Continuous injections of anti - IL-18 antibody failed to inhibit the onset and development of dermatitis and IgE elevation . - pubmed
In addition , the administration of anti - IL-18 antibody did not ameliorate the responsiveness of lymphocytes to IL-4 , which was previously demonstrated as an immunological abnormality in the mouse . - pubmed
CONCLUSION : This study demonstrates that , at least in NC / Nga mice , IL-18 , although excessively expressed before the onset of dermatitis , shows antiallergic actions . - pubmed
Immunohistochemical examination of P - cadherin in bullous and acantholytic skin diseases . - pubmed
We examined the expression of P - cadherin in some autoimmune bullous skin diseases and Darier ' s disease using immunohistochemistry and found P - cadherin to be strongly upregulated . - pubmed
Influence of hepatitis C virus infection on soluble cellular adhesion molecules in hemodialysis patients . - pubmed
BACKGROUND / AIMS : Higher levels of soluble cellular adhesion molecules have been found to be a strong indicator of endothelial dysfunction and atherosclerosis in the general population . - pubmed
We conducted a cross - sectional association study of soluble cellular adhesion molecules and hepatitis C in maintenance hemodialysis patients . - pubmed
HCV infection was determined as an independent determinant of sICAM-1 and sVCAM-1 by multiple linear regression analysis . - pubmed
AIDS status with HIV viral load and CD4 T - cell count were measured at the beginning and at the end of the treatment . - pubmed
Niemann - Pick disease type C ( NPC ) is a genetic disorder in which patient cells exhibit lysosomal accumulation of cholesterol and sphingolipids ( SLs ) caused by defects in either NPC1 or NPC2 proteins . - pubmed
In the current study , we used protein transduction to further investigate Rab9 - mediated reduction of stored lipids in NPC cells . - pubmed
When VP22 - Rab9 was transduced into NPC1 fibroblasts , nearly all cells showed significant reduction in cellular free cholesterol levels , with no cytotoxicity up to 5 microM. - pubmed
These observations provide important new information about the correction of membrane traffic in NPC cells by Rab9 overexpression and may lead to new therapeutic approaches for treatment of this disease . - pubmed
Effect of inducers of DT - diaphorase on the haemolytic activity and nephrotoxicity of 2 - amino-1,4 - naphthoquinone in rats . - pubmed
In the present study , the effect of several substances that are known to increase tissue activities of DT - diaphorase on the toxicity of 2 - amino-1,4 - naphthoquinone has been investigated . - pubmed
Again like 2 - hydroxy-1,4 - naphthoquinone , the severity of the haemolysis induced by the 2 - amino derivative was increased in animals pre - treated with inducers of DT - diaphorase , but the degree of nephrotoxicity was decreased . - pubmed
It is not possible to generalize with regard to the effects of modulation of tissue levels of DT - diaphorase on naphthoquinone toxicity in vivo , since this may change not only the severity of the toxic effects , but also the target organ specificity . - pubmed
In man , renal damage by compounds such as 2 - hydroxy - and 2 - amino-1,4 - naphthoquinone may be a particular problem , because of the low level of DT - diaphorase in human liver . - pubmed
Evidence for a tumour suppressive function of APRG1 in breast cancer . - pubmed
RESULTS : Levels of APRG1 mRNA were lower in malignant tissues . - pubmed
There was a statistically significant reduction in APRG1 in grade 3 tumours cf . - pubmed
APRG1 expression was highly negatively correlated with progressive disease : alive with metastasis ( p = 0.0069 ) , local recurrence ( p = 0.0055 ) , died of breast cancer ( p = 0.11 ) , all progressive disease ( p = 0.035 ) . - pubmed
There was also a statistically significant difference in APRG1 levels between grade 3 and grade 1 tumours . - pubmed
These results are highly suggestive of APRG1 acting as a tumour suppressor gene . - pubmed
Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2 . - pubmed
Mutations in LMAN1 ( ERGIC-53 ) or MCFD2 cause combined deficiency of factor V and factor VIII ( F5F8D ) . - pubmed
Falsely low LDL cholesterol results and cholestasis . - pubmed
Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia . - pubmed
Progenitor cells from patients with beta ( 0 ) thalassemia generated in vitro morphologically normal proerythroblasts that , unlike normal cells , failed to mature in the presence of EPO and expressed low beta - globin levels but 10 times higher - than - normal levels of the alpha hemoglobin - stabilizing protein ( AHSP ) mRNA . - pubmed
The low toxicity exerted by compounds 9 and 24 in all of the assays investigated suggests that these new HDAC inhibitors should be considered for personalized therapy of selected patients with beta(0 ) thalassemia . - pubmed
We and others have previously demonstrated that high D - glucose induced apoptosis through activation of the bax - caspase proteases pathway in human EC and the potential contribution of hepatocyte growth factor , as an anti - apoptotic factor , to the pathogenesis of endothelial dysfunction . - pubmed
Recent work strongly suggests that NADPH oxidase is a major source of superoxide in cardiovascular cells , and oxidative stress can be involved in the process of endothelial dysfunction . - pubmed
NADPH oxidase can be activated in hyperglycemia through the protein kinase C pathway . - pubmed
From the viewpoint of these molecular mechanisms , HMG - CoA reductase inhibitors ( statins ) might inhibit the high glucose - induced NADPH oxidase activation through inhibition of Rac activity and finally prevent the increase in ROS production in diabetes . - pubmed
Filaggrin mutations are associated with ichthyosis vulgaris in the Bangladeshi population . - pubmed
Histopathological analyses of the antitumor activity of anti - glypican-3 antibody ( GC33 ) in human liver cancer xenograft models : The contribution of macrophages . - pubmed
Previously , we demonstrated the antitumor efficacy of the anti - glypican-3 ( GPC3 ) antibody GC33 in several human liver cancer xenograft models and the important role of antibody - dependent cellular cytotoxicity ( ADCC ) in the antitumor mechanism of GC33 . - pubmed
In this study , we investigated histopathologically time - course changes in xenografts in mice following a single administration of GC33 to clarify the morphological changes contributing to the tumor growth inhibition of GC33 , including the changes in GPC3 - related factors / components [ proliferation , extracellular matrices ( ECMs ) and macrophage ] . - pubmed
The results indicate that the 2 - hexyl compound 6f act as the most powerful mechanism - based inactivator of aromatase among Delta ( 1 )- AD analogs and may be submitted to the preclinical study in estrogen - dependent breast cancer . - pubmed
It is classically characterized by tumors in the head and neck region with associated eosinophilia and elevated serum immunoglobulin E levels . - pubmed
T - cell receptor gene rearrangement studies using 2 different techniques did not detect any clonality for T - cell receptor in both KD and MF lesions . - pubmed
CKS1B nuclear expression is inversely correlated with p27Kip1 expression and is predictive of an adverse survival in patients with multiple myeloma . - pubmed
We and others have shown that CKS1B amplification located on chromosome 1q21 is an adverse prognostic factor in multiple myeloma , but its relationship with CKS1B nuclear protein expression , is unclear . - pubmed
The aim of this study was to correlate nuclear CKS1B protein immunoreactivity , 1q21 amplification status , p27 ( Kip1 ) expression and survival in patients with newly - diagnosed multiple myeloma . - pubmed
DESIGN AND METHODS : Nuclear expression of CKS1B and p27 ( Kip1 ) was evaluated by immunohistochemistry in decalcified , paraffin - embedded bone marrow biopsies from 94 patients with newly diagnosed multiple myeloma . - pubmed
CONCLUSIONS : Immunohistochemistry for CKS1B is a simple , rapid method that appears to predict 1q21 amplification and adverse outcome for risk stratification of patients with multiple myeloma . - pubmed
The RET51 / FKBP52 complex and its involvement in Parkinson disease . - pubmed
To clarify if RET51 / FKBP52 complex should exert its function in DA neurons , we used an indirect approach by screening the genes encoding for RET51 and FKBP52 in a group of 30 Parkinson ' s disease patients . - pubmed
We found a compound heterozygous carrying two mutations in RET and FKBP52 that are sufficient to disrupt the RET51 / FKBP52 complex , indicating its potential role in PD . - pubmed
CARD15 mutations and perianal fistulating Crohn ' s disease : correlation and predictive value of antibiotic response . - pubmed
BACKGROUND : CARD15 mutations alter bowel immunity and increase susceptibility to Crohn ' s disease ( CD ) . - pubmed
AIMS : To assess whether CARD15 mutations are associated with risk of developing Crohn ' s perianal fistulas and whether these mutations are predictors of the response of perianal fistulas to antibiotics . - pubmed
METHODS : CARD15 mutations were investigated in 203 consecutive CD patients . - pubmed
Patients with history of perianal fistula were divided into two groups ( with / without CARD15 mutations ) , and response to antibiotics was evaluated in both groups . - pubmed
RESULTS : Of the 203 patients , 60 ( 29.6 % ) showed at least one CARD15 mutation and 55 ( 27.1 % ) had history of perianal fistula . - pubmed
Mean age at diagnosis of first perianal fistula was similar in patients with / without CARD15 mutations ( 28.7 + - 9.8 versus 29.7 + - 10.1 years , P = 0.758 ) . - pubmed
Response of perianal fistulas to antibiotics ( metronidazole alone or combined with ciprofloxacin ) was significantly higher in patients without CARD15 mutations ( 7.7 % versus 40.5 % , P = 0.041 ) . - pubmed
CONCLUSIONS : In CD , CARD15 mutations are not associated with risk of developing perianal fistulas or with time of their outbreak . - pubmed
Nevertheless , patients with perianal fistulas and CARD15 mutations showed worse response to antibiotics . - pubmed
This conference report highlights selected presentations on targeting pathological tau for the prevention or treatment of Alzheimer ' s disease . - pubmed
Factor V Leiden mutation ( G1691A ) ( FVL ) is the most common risk factor in venous thrombosis . - pubmed
Nephropathy was defined as microalbuminuria ( urinary albumin - creatinine ratio [ ACR ] : 30 to 299 mg / g ) , macroalbuminuria ( urinary ACR : & gt;= 300 mg / g ) , or an estimated glomerular filtration rate of & lt;60 mL / min/1.73 m(2 ) . - pubmed
A positive tuberculin skin test ( TST ; RR 3.54 , 95%CI 1.13 - 11.11 , P = 0.03 ) and previously healed TB on chest radiograph ( CXR ; RR 8.71 , 95%CI 1.00 - 75.84 , P = 0.05 ) were significant pre - transplant risk factors for post - transplant TB on multivariate analysis . - pubmed
Combination of autoantibodies against different histone proteins influences complement - dependent phagocytosis of necrotic cell material by polymorphonuclear leukocytes in systemic lupus erythematosus . - pubmed
We evaluated the roles of complement , different antihistone antibodies ( anti - H ab ) , and oxidative burst in the phagocytosis of NC by PMN , as well as association to disease activity and clinical phenotype in SLE . - pubmed
METHODS : ELISA and immunoblot were used to measure antibodies to different histone proteins in sera from patients with SLE and complement - deficient individuals . - pubmed
RESULTS : A clearly increased phagocytosis of NC was seen in patients with active SLE , which was associated with high levels of anti - H ab concentrations and oxidative burst activity . - pubmed
CONCLUSION : The distributions of specificities among anti - H ab are of great importance in the complement - dependent phagocytosis of debris from NC in SLE . - pubmed
Therapeutic options for bleeding prevention in FVII deficient patients undergoing surgery comprise various FVII preparations but the use of recombinant activated factor VII ( rFVIIa ) seems to be the treatment of choice . - pubmed
None of our patients developed excessive bleeding including those in whom FVII : C trough levels returned nearly to the baseline level on the first post - op day . - pubmed
Shh treatment leads to inhibition of retinoblastoma protein ( pRb ) by increasing phosphorylated pRb and reducing retinoblastoma gene transcription . - pubmed
Mitochondrial neurogastrointestinal encephalopathy ( MNGIE ) is caused by deficiency in thymidine phosphorylase ( TP ) , that regulates thymidine ( dThd ) and deoxyuridine ( dUrd ) . - pubmed
Expression of Bcl-2 and the antiapoptotic BAG family proteins in ovarian cancer . - pubmed
In epithelial ovarian cancer ( EOC ) , literature on the prognostic value of B - cell lymphoma 2 ( Bcl-2 ) is limited and inconsistent . - pubmed
The major aim of this study was to further define the expression pattern and the prognostic role of Bcl-2 together with BAG-1 , BAG-3 , and BAG-4 proteins in EOC patients receiving platinum / taxane - based chemotherapy . - pubmed
The expression and the prognostic value of Bcl-2 , BAG-1 , BAG-3 , and BAG-4 in EOC were evaluated by immunohistochemistry and multivariate analysis . - pubmed
A positive cytoplasmic staining for Bcl-2 was observed in 23.8 % of EOC samples and in all histologic subtypes . - pubmed
BAG-1 , BAG-3 , and BAG-4 were detected in tumor cell nuclei and cytoplasm . - pubmed
Expression of Bcl-2 , or the BAG family proteins , independent of nuclear or cytoplasmic localization , had no significant impact on either disease - free or overall survival , both in univariate and multivariate survival analyses with the limitation of a small cohort of cases . - pubmed
In this study , no association between Bcl-2 expression in EOC tumor tissue and prognosis was found . - pubmed
Oral L - glutamine increases active GLP-1 ( 7 - 36 ) amide secretion and improves glycemic control in stretpozotocin - nicotinamide induced diabetic rats . - pubmed
It decreased blood sugar , stimulated insulin secretion in type 2 diabetic patients . - pubmed
The objective of the present investigation was to evaluate L - glutamine increases glucagon like peptide-1 ( GLP-1 ) ( 7 - 36 ) amide secretion in streptozotocin - nicotinamide ( STZ - NTM ) induced diabetic Sprague Dawley rats . - pubmed
L - glutamine decreased plasma glucose , increased plasma and pancreatic insulin , increased plasma and colonic active GLP-1 ( 7 - 36 ) amide secretion as well as decreased oxidative stress in streptozotocin - nicotinamide induced diabetic rats . - pubmed
Synthesis , preclinical validation , dosimetry , and toxicity of 68Ga - NOTA - anti - HER2 Nanobodies for iPET imaging of HER2 receptor expression in cancer . - pubmed
Biodistribution and PET / CT studies were performed on HER2 - positive and -negative tumor xenografts . - pubmed
Biodistribution studies showed fast and specific uptake ( percentage injected activity [ % IA ] ) in HER2 - positive tumors ( 3.13 + - 0.06 and 4.34 + - 0.90 % IA / g for ( 68 ) Ga - NOTA-2Rs15dHis6 and ( 68 ) Ga - NOTA-2Rs15d , respectively , at 1 h after injection ) and high tumor - to - blood and tumor - to - muscle ratios at 1 h after injection , resulting in high - contrast PET / CT images with high specific tumor uptake . - pubmed
The injected mass showed an effect on the general biodistribution : a 100 - fold increase in NOTA-2Rs15d mass decreased liver uptake from 7.43 + - 1.89 to 2.90 + - 0.26 % IA / g whereas tumor uptake increased from 2.49 + - 0.68 to 4.23 + - 0.99 % IA / g. The calculated effective dose , based on extrapolation of mouse data , was 0.0218 mSv / MBq , which would yield a radiation dose of 4 mSv to a patient after injection of 185 MBq of ( 68 ) Ga - NOTA-2Rs15d . - pubmed
Preclinical validation showed high - specific - contrast imaging of HER2 - positive tumors with no observed toxicity . - pubmed
Up - regulation of urinary markers predict outcome in IgA nephropathy but their predictive value is influenced by treatment with steroids and azathioprine . - pubmed
OBJECTIVE : Steroids and immunosuppressants can delay progression of renal function in IgAN , but their possible effect in local cytokines has not been studied . - pubmed
Serum creatinine at time of diagnosis had significant correlation with proteinuria ( p = 0.02 ) , urinary levels of IL-1beta ( p = 0.03 ) , IL-2 ( p = 0.01 ) and MCP-1 ( p = 0.03 ) . - pubmed
Most of the measured cytokines in the urine predicted deterioration of renal function in Group A , but the urinary excretion of IL-6 seemed to predict renal function outcome in both groups of patients . - pubmed
CONCLUSION : Several cytokines are excreted in the urine of patients with IgAN , and their levels predict the outcome of the disease . - pubmed
Our results suggest that Nrf2 probably inhibits RANKL - induced OC differentiation by regulating the cellular redox status by controlling the expression of oxidative response genes , findings that might form the basis of a new strategy for treating inflammatory bone diseases . - pubmed
Increased immunoglobulin ( Ig ) G4 - positive plasma cell density and IgG4 / IgG ratio are not specific for IgG4 - related disease in the skin . - pubmed
OBJECTIVES : Immunoglobulin ( Ig ) G4 - related disease ( IgG4 - RD ) , a fibroinflammatory condition that can affect multiple organs , is suggested by lymphoplasmacytic inflammation , fibrosis , phlebitis , and increased IgG4 + plasma cell ( PC ) tissue density . - pubmed
We aimed to determine whether increased cutaneous IgG4 + PCs or IgG4 / IgG ratio is specific for IgG4 - RD . - pubmed
METHODS : We examined 50 mucocutaneous specimens representing seven PC - rich dermatoses and reactive PC - rich infiltrates with IgG and IgG4 immunohistochemical stains . - pubmed
The M3 and M2 muscarinic acetylcholine receptors ( mAChRs ) and beta-2 - adrenoceptors ( beta2ARs ) are important regulators of airway cell function , and drugs targeting these receptors are among the first line drugs in the treatment of the obstructive lung diseases asthma and chronic obstructive lung disease ( COPD ) . - pubmed
We conclude by discussing how recent advances in GPCR pharmacology offer a unique opportunity to fine tune mAChR and beta2AR signaling and their crosstalk , and thereby produce superior therapeutics for obstructive lung and other diseases . - pubmed
Results showed that the retinoic acid receptor alpha ( RARalpha ) , a target protein in acute promyelocytic leukemia ( APL ) , was in the top rank , with a pharmacophore model matching well the molecular features of Tanshinone IIA . - pubmed
These results indicated that RARalpha may be a potential target of Tanshinone IIA for APL . - pubmed
Oral administration of carvedilol at a dose level of 1 and 10 mg / kg daily for 4 weeks resulted in nephroprotective effect as evident by significant decrease in serum creatinine level , urinary albumin / creatinine ratio , and kidney index as well as renal levels of malondialdehyde , nitric oxide , tumor necrosis factor - alpha , and cyclooxygenase-2 with a concurrent increase in creatinine clearance and renal reduced glutathione level compared to diabetic untreated rats . - pubmed
Anti - aquaporin-4 autoantibodies in systemic lupus erythematosus persist for years and induce astrocytic cytotoxicity but not CNS disease . - pubmed
Anti - aquaporin-4 autoantibodies are specific for the neuromyelitis optica spectrum disorders ( NMOSD ) and they have also been described in patients with systemic lupus erythematosus ( SLE ) with neurological signs consistent with NMOSD . - pubmed
Our objective was to test for the presence and pathogenicity of anti - AQP4 antibodies in SLE patients without neurological disease . - pubmed
Sera from 89 non - CNS - SLE patients were screened for anti - AQP4 autoantibodies . - pubmed
An in vitro cytotoxicity assay showed that either sera or purified IgG from these patients induced a complement - mediated damage in cultured astrocytes comparable to antibodies obtained from typical NMO patients . - pubmed
We conclude that AQP4 - antibodies can be present in SLE patients and persist for many years , without concurrent clinical or radiological NMOSD signs . - pubmed
It is unclear why the anti - AQP4 antibodies did not induce CNS disease . - pubmed
Although the clinical situation and the blood haemoglobin concentration are the key factors considered in this rapid decision - making context , laboratory markers should not be based on a single haematocrit value , as its sensitivity to significant bleeding may be very low . - pubmed
Serum lactate and base deficit are very sensitive markers for detecting and monitoring the extent of bleeding and shock , in conjunction with repeated combined measurements of prothrombin time , activated partial thromboplastin time , fibrinogen and platelets . - pubmed
Since the almost complete absence of dystrophin is the underlying cause for X - linked muscular dystrophy , a more detailed understanding of the composition , structure and plasticity of the dystrophin complexome may have considerable biomedical implications . - pubmed
Two Chitotriose - Specific Lectins Show Anti - Angiogenesis , Induces Caspase-9 - Mediated Apoptosis and Early Arrest of Pancreatic Tumor Cell Cycle . - pubmed
The growth inhibitory effect of these lectins on pancreatic cancer cells were shown to be a consequence of lectin cell surface binding and triggering G0 / G1 arrest , mitochondrial membrane depolarization , sustained increase of the intracellular calcium release and the apoptotic signal is amplified by activation of caspases executing cell death . - pubmed
Therefore , we report for the first time two chito - specific lectins specifically binding to tumor glycans ; they can be considered to be a class of molecules with antitumor activity against pancreatic cancer cells mediated through caspase dependent mitochondrial apoptotic pathway . - pubmed
IgG4 - related disease is the term used to refer to a condition characterized by a lymphoplasmacytic infiltrate , fibrosis and an increased number of IgG4 + cells present in tissue , in most cases , with an elevated serum IgG4 level . - pubmed
OBJECTIVES : Controversy exists about the integration of erlotinib in patients with EGFR wildtype , advanced NSCLC . - pubmed
Cancer stem cell marker CD90 inhibits ovarian cancer formation via beta3 integrin . - pubmed
CD90 , one of the characterized markers in liver and gastric cancer , is shown to promote cancer formation . - pubmed
However , the underexpression level of CD90 in ovarian cancer cells and the evidence supporting the cellular mechanism have not been investigated . - pubmed
In the present study , we found that the DNA copy number of CD90 is correlated with mRNA expression in ovarian cancer tissue and the ovarian cancer patients with higher CD90 have good prognosis compared to the patients with lower CD90 . - pubmed
Although the expression of CD90 in human ovarian cancer SKOV3 cells enhances the cell proliferation by MTT and anchorage - dependent growth assay , CD90 inhibits the anchorage - independent growth ability in vitro and tumor formation in vivo . - pubmed
Our results provide evidence that CD90 mediates the antitumor formation by interacting with beta3 integrin , which provides new insight that can potentially be applied in the development of therapeutic strategies in ovarian cancer . - pubmed
MTI was defined by a positive interferon - gamma release assay . - pubmed
We present a case of a 66 - year - old lady with chest pain , without dynamic 12 - lead electrocardiographic ( ECG ) changes and normal serial troponin . - pubmed
CONCLUSIONS : These results showed that the human heart expresses the TH biosynthesis machinery , being altered its main enzymatic system in patients with ICM . - pubmed
Given the relevance of TH in cardiac pathology , our results provide a foundation for new therapeutic approaches based on TPO for treating ICM . - pubmed
ASK1 ( MAP3K5 ) is transcriptionally upregulated by E2F1 in adipose tissue in obesity , molecularly defining a human dys - metabolic obese phenotype . - pubmed
We hypothesized that a transcriptional AT stress - signaling cascade involving E2F1 and ASK1 ( MAP3K5 ) molecularly defines high - risk obese subtype . - pubmed
METHODS : ASK1 expression in human AT biopsies was determined by real - time PCR analysis , and chromatin immunoprecipitation ( ChIP ) adopted to AT explants was used to evaluate the binding of E2F1 to the ASK1 promoter . - pubmed
RESULTS : Human visceral - AT ASK1 mRNA ( N = 436 ) was associated with parameters of obesity - related cardio - metabolic morbidity . - pubmed
Adjustment for E2F1 expression attenuated the association of ASK1 with fasting glucose , insulin resistance , circulating IL-6 , and lipids ( triglycerides , HDL - cholesterol ) , even after adjusting for BMI . - pubmed
CONCLUSIONS : AT E2F1 -ASK1 molecularly defines a metabolically - detrimental obese sub - phenotype . - pubmed
Interleukin-1 receptor - associated kinase 1 correlates with metastasis and invasion in endometrial carcinoma . - pubmed
Previous studies have investigated the altered expression of interleukin-1 receptor - associated kinase 1 ( IRAK1 ) in various cancers . - pubmed
We aimed at exploring the biological function and the underlying molecular mechanism of IRAK1 in EC . - pubmed
In this study , IRAK1 was found elevated in EC compared with normal tissues . - pubmed
Further , high IRAK1 expression level was correlated with higher tumor stage , lymph node metastasis , myometrial invasion , and lower survival rate . - pubmed
Knockdown of IRAK1 in two EC cell lines , HEC-1 - B and JEC , significantly inhibited cell proliferation in vitro and in vivo . - pubmed
We also found that down - regulation of IRAK1 in EC cells notably induced cell cycle arrest and apoptois , and also inhibited cell migration and invasion . - pubmed
Gene set enrichment analysis on The Cancer Genome Atlas dataset showed that Kyoto Encyclopedia of Genes and Genomes ( KEGG ) mitotic cell cycle and cell division pathways were correlative with the IRAK1 expression , which was further confirmed in EC cells by Western blot . - pubmed
These collective data indicated that IRAK1 overexpression promotes EC tumorigenesis by activating mitotic cell cycle and cell division pathways , and IRAK1 may serve as a promising therapeutic strategy for EC . - pubmed
There is now ample evidence for a role of IL-18 in various infectious , metabolic or inflammatory diseases such as influenza virus infection , atheroma , myocardial infarction , chronic obstructive pulmonary disease , or Crohn ' s disease . - pubmed
However , IL-18 plays a very specific role in the pathogenesis of hemophagocytic syndromes ( HS ) also termed Macrophage Activation Syndrome . - pubmed
HS is treated with the IL-1 Receptor antagonist ( anakinra ) but also specifically with IL-18BP . - pubmed
Systemic juvenile idiopathic arthritis or adult - onset Still 's disease are also characterized by high serum IL-18 concentrations and are treated by IL-18BP . - pubmed
Moreover , the protein expression levels of tumor necrosis factor alpha ( TNF - alpha ) and the Bcl-2 - associated X protein ( Bax)/b cell leukemia / lymphoma 2 protein ( Bcl-2 ) ratio were significantly lower at brain injury sites in mice of group MG than those of group PBS . - pubmed
A number of different genes have been shown to be associated with cases of tooth agenesis including AXIN2 , IRF6 , FGFR1 , MSX1 , PAX9 , and TGFA . - pubmed
Wingless / integration signaling gene , AXIN2 , is linked to tooth agenesis and also to colorectal cancer ( CRC ) . - pubmed
HmTSP expression in polyps was restricted to the hypostomal tip and tentacle bases that harbor Wnt - regulated organizer tissues . - pubmed
The serum samples were tested for the presence of antibodies against outer membrane porin C ( anti - OmpC ) , Pseudomonas fluorescens bacterial sequence I2 ( anti - I2 ) , anti - laminarin ( anti - L ) , anti - chitin ( anti - C ) , anti - chitobioside carbohydrate antibody ( ACCA ) , anti - laminaribioside carbohydrate antibody ( ALCA ) , anti - mannobioside carbohydrate antibody ( AMCA ) , and anti - Saccharomyces cerevisiae antibody ( ASCA ) by indirect enzyme - linked immunosorbent assay ( ELISA).Individually , anti - C , anti - L , ASCA - IgG , and ALCA lacked diagnostic value in the differentiation of CD . - pubmed
ASCA - IgA remained the most accurate marker for the diagnosis of CD , with an area under the curve ( AUC ) of 0.77 ; however , its sensitivity and specificity were both lower than 75 % . - pubmed
Among the combinations of the 5 markers with significant diagnosing ability for CD , combinations with any 2 of the 3 markers , ASCA IgA , AMCA , and ACCA positive , provided the best accuracy in the diagnosis and differential diagnosis of CD ( sensitivity and specificity both above 75 % ) and had the highest Youden index . - pubmed
For testicular development in cyp17a1 - deficient fish , a gradually increasing number of spermatozoa and testis hypertrophy from 3 to 6 mpf were observed , accompanied by constitutively upregulated pituitary gonadotropin FSH subunit beta ( fshbeta ) . - pubmed
The hypertrophic testis and enhanced spermatogenesis in the cyp17a1 - deficient fish at 6 mpf could be effectively rescued by fshbeta depletion . - pubmed
On the other hand , the hydroxyls groups available on MSNs surface allows the conjugation of specific molecules which can binds to the overexpressed Enhanced Growth Factor Receptor ( EGFR ) in many tumors , representing a potential strategy for the cancer treatment . - pubmed
Here , we report a case of IgG4 - related RPF remission that was only coronary arterial involvement after treatment . - pubmed
CXCR5 + T CD8 + T - cells play an important role in the control of viral infections and tumors . - pubmed
HIV infection did not affect the frequencies of CXCR5 + CD8 + T - cells in secondary lymphoid organs . - pubmed
Alterations in DNase activity have been implicated as the cause of various cancers and autoimmune diseases . - pubmed
However , histological evidence of lung injury ( Lung Injury Score mean difference -0.07 , p = 0.04 ) and BAL IL-8 were reduced . - pubmed
Therapeutic effects of IkB kinase inhibitor during systemic inflammation . - pubmed
Animal models of inflammatory diseases support the idea that nuclear factor kappaB ( NF - kappaB ) activation plays a pathophysiological role and is widely implicated in multiple organ dysfunction ( MOD ) . - pubmed
Indeed , the inhibition of the IkappaB kinase ( IKK ) complex , involved in the NF - kappaB pathway , can represent a promising approach to prevent MOD . - pubmed
The present work employed a rat model of systemic inflammation to investigate the preventive effects of Inhibitor of IKK complex ( IKK16 ) . - pubmed
The present study provides convincing evidence that selective inhibition of the IkappaB kinase complex through the action of IKK16 , plays a protective role against LPS - induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure . - pubmed
The aim of our study is to assess the diagnostic performance of the test to detect the placental alpha microglobulin 1 ( PAMG-1 ) for the prediction of delivery within 7 days in women with TPD . - pubmed
This review presents the cardiovascular and metabolic benefits of GLP-1 RAs versus placebo , in patients with type 2 diabetes . - pubmed
However , the international guidelines recommend using GLP-1 RAs as first - line therapy in type 2 diabetes patients with high cardiovascular risk or as first - line agents in patients intolerant to metformin . - pubmed
Results : The percentages of patients with high HA levels in menopause and non - menopause patientswere 55.7 % and 40.5 % , respectively ; in progesterone receptor ( PR ) positive and negative patients were 54.1 % and 43.2 % , respectively ; in estrogen receptor ( ER ) positive and negative patients were 45.7 % and 60.7 % , respectively ; in Ki-67 positive and negative patients were 55.6 % and 43.2 % , respectively ; in the tumor size stage TI , TII , TIII , and TIV patients were 50.0 % , 41.7 % , 72.7 % , and 1/1 , respectively ; in lymph node metastasis and non - metastasispatients were 45.7 % and 53.8 % , respectively . - pubmed
There was no significant correlation between the level of HA and the menopausal status , the expressions of PR , ER and Ki-67 , tumor size , and lymph node metastasis in breast cancer patients ( chi2=2.128 , 1.086 , 1.800 , 1.485 , 4.273 , 0.656 , P>0.05 ) . - pubmed
Patients with high HA levels accounted for 30.9 % of patients aged 52 years or less and 74.4 % of patients older than 52 years ( chi2=18.274 , P=0.000 ) ; 43.4 % of patients with early TNM and 72.7 % of patients with advanced TNM ( chi2=5.861 , P=0.015 ) ; 45.2 % of patients without distant metastasis and 78.6 % of patients with distant metastasis ( chi2=5.333 , P=0.023 ) ; 38.1 % of Her-2 negative patients and 58.9 % of Her-2 positive patients(chi2=4.167 , P=0.041 ) ; and the median survival of patients with high HA levels was 70 months , which was shorter than 83 months for patients with low HA levels ( chi2=6.799 , P=0.007 ) . - pubmed
Therefore , ahigh HA content predicts an older age , a later tumor stage , higher risk of distant metastasis , positive expression of Her-2 and shorter survival . - pubmed
Conclusion : The high level of preoperative serum HA has a certain correlation with the poor prognosis of breast cancer patients . - pubmed
CONCLUSION : Troponin I showed the best diagnostic performance for predicting cardiac injury in patients with CO poisoning . - pubmed
However , further studies on cardiac biomarkers and other diagnostic tools in CO poisoning are needed given the low sensitivity of troponin I. - pubmed
Correlation analysis showed a negative correlation between the level of high - density lipoproteins ( HDL ) and calcium volume ( r= -0.4104 ; r=0.023 ) ; a positive correlation between the blood glucose level as determined by the oral glucose tolerance test and the lipid component ( r=0.48198 ; r=0.033 ) ; and a negative correlation between the apolipoprotein A level and the calcium volume ( r= -0.4297 ; r=0.008).Conclusion The study demonstrated a high prevalence of vulnerable plaques in nontarget coronary arteries in patients with sIHD . - pubmed
In this process , dyslipidemia indexes ( LDL , apolipoproteins A ) correlate with the calcium volume whereas blood glucose , as measured in the oral glucose tolerance test , correlates with the lipid component of coronary plaque . - pubmed
With exception of CRP values ( 25.0 vs. 5.0 mg / L , P = 0.015 ) , irrigation volumes ( 800 vs. 500 mL , P = 0.01 ) and total points of two predictive models ( Nomogram 1 : 88.0 vs. 76.0 , P < 0.001 ; Nomogram 2 : 76.0 vs. 39.0 , P = 0.016 ) , there was no statistical difference detected between the fever and non - fever groups . - pubmed
[ Effect of electroacupuncture on Leptin in energy - regulated signaling of obese rats with insulin resistance ] . - pubmed
OBJECTIVE : To observe the effect of electroacupuncture ( EA ) on Leptin and Leptin receptor ( OB - Rb ) of insulin resistant obese ( OIR ) rats , so as to explore its possible mechanism for obesity . - pubmed
BACKGROUND : Blood groups and anti - A isohemagglutinin may be involved in susceptibility to SARS - CoV-2 infection . - pubmed
Occurrence of immune complexes in malignant pleural effusions has been investigated by the 125I - c1q binding test . - pubmed
55 % of the pleural effusions had C1q binding activity levels higher than those found in transudates used as controls . - pubmed
The levels of C1q binding activity in effusions were significantly higher than those found in the serum of the same cancer patients . - pubmed
High levels of C1q binding activity were found in malignant effusion independently of type or differentiation of the tumors involved . - pubmed
[ Treatment of patients with multiple sclerosis with transfer factor ( author 's transl ) ] . - pubmed
These changes included an increase in muscle weight , a decline in normalised peak twitch and tetanic tensions , and normalised force in response to different stimulation frequencies ( Rosenblatt , 1992 ) , an increase in the relative number of type I fibres and of fibres reacting with the slow myosin heavy chain antibody , an increase in whole muscle cross - sectional area , an increase in type I and type II fibre cross - sectional area and diameter , an increase in myofibril cross - sectional area , density , number , and area fraction , and an increase in the relative proportion of intramuscular connective tissue collagen . - pubmed
Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single - stranded conformational polymorphisms . - pubmed
We analyzed single - stranded conformational polymorphisms to screen for mutations and polymorphisms in the insulin receptor gene in subjects with or without insulin resistance . - pubmed
In addition , a new mutation was found in exon 20 of the insulin receptor gene in a patient with moderate insulin resistance associated with morbid obesity , acanthosis nigricans , and polycystic ovary syndrome . - pubmed
These data demonstrate that analysis of single - stranded conformational polymorphisms is a simple and sensitive screening method for mutations and polymorphisms in the insulin receptor gene in subjects with or without insulin resistance . - pubmed
Identification of a mutation in the insulin receptor gene in a patient with a moderate degree of insulin resistance associated with morbid obesity suggests that insulin receptor mutations may exist in patients with Type 2 ( non - insulin - dependent ) diabetes mellitus associated with a moderate degree of insulin resistance . - pubmed
We have used immunohistochemical methods to demonstrate the intracellular localization of the proteins actin , myosin , tropomyosin and vinculin , which are thought to be responsible for cellular contraction , in 26 surgically obtained epiretinal traction membranes from patients with traumatic ( n = 12 ) and idiopathic ( n = 7 ) proliferative vitreoretinopathy , and proliferative diabetic retinopathy ( n = 7 ) . - pubmed
[ Multidisciplinary therapy using interferon and immunological evaluation for glioma patients : two - color analysis of T cell subsets ] . - pubmed
We have employed IAR therapy [ combination of postirradiation , chemotherapy and interferon ( IFN ) ] for malignant glioma patients . - pubmed
Eight malignant glioma patients received irradiation , chemotherapy ( ACNU ) and immunotherapy ( OK-432 and IFN - beta ) . - pubmed
Thus we conclude that RP 67580 , a SP antagonist , belongs to a class of drugs that may be useful in the management of various clinical pathologies where pain and neurogenic inflammation are involved . - pubmed
Linkage analysis of two murine polycystic kidney disease genes , pcy and cpk . - pubmed
This indicates that the cpk and pcy genes are not alleles and that the genetic mechanism of PKD pathogenesis in the mouse is different from that in the Cy rat . - pubmed
The metastatic invasion of basement membrane by tumor cells involves the binding of tumor cells to laminin . - pubmed
Both tumor and normal cells express a high - affinity receptor for laminin ; however , the expression is more pronounced with tumor cells . - pubmed
The binding of tumor cells to laminin can be inhibited competitively by YIGSR and , in mice , this has been shown to be translated into a reduction in metastasis . - pubmed
Immobilized vitronectin was found to bind both purified plasminogen activator inhibitor type 1 ( PAI-1 ) and the PAI-1 in conditioned culture medium of human sarcoma cells . - pubmed
Enzyme immunoassay of progesterone receptor in breast cancer biopsy samples . - pubmed
Progesterone receptor was measured in 97 breast cancer biopsy samples with two methods , the multiple point dextran coated charcoal method with Scatchard analysis and enzyme immunoassay . - pubmed
[ Immunoenzyme test system with monoclonal antibodies to human IgG4 in the determination of allergen - specific antibodies in pollinosis ] . - pubmed
Specific hyposensitization resulted in significant increase of IgG4 antibody level in patients with tree pollen allergy . - pubmed
Determination of IgG4 antibodies is proved to be useful to reveal tree pollen allergy and to monitor hyposensitization therapy . - pubmed
The transient appearance at S2 of anti - cytomegalovirus antibodies brought by transfusion was observed in 40 % of the cases ; seroconversion occurred in 4 % ( cytomegalovirus 3 , hepatitis B virus 1 ) , and 5 % of the patients developed clinical and biochemical hepatitis without serological markers . - pubmed
K dependence of the Na - K pump is abnormal in erythrocytes from patients with cystic fibrosis and obligate heterozygotes . - pubmed
The affinity of the Na - K pump for K was significantly ( P less than .001 ) lower in erythrocytes from patients with cystic fibrosis ( Km 4.6 + /- 0.35 mM ; n = 26 ) or from heterozygotes ( Km 3.9 + /- 0.57 mM ; n = 12 ) than in controls ( Km 2.2 + /- 0.10 mM ; n = 20 ) . - pubmed
The affinity of the Na - K pump for K was lower in normal erythrocytes than in normal fibroblasts which may explain the variability in the severity of involvement of different organs in cystic fibrosis . - pubmed
We have now shown in human skin fibroblasts and erythrocytes , that the K affinity of the Na - K pump is lower in patients with cystic fibrosis than in controls . - pubmed
These results demonstrate that the inhibition of platelet aggregation by compound 48 / 80 is not due solely to effects on calmodulin as previously reported , but that inhibition of phospholipases and probably arachidonate mobilization may also be involved . - pubmed
Relationship of virulent and attenuated RNA oncogenic virus antigens to surface antigens of the virus - transformed cell : implications for the reverse transcriptase system , the provirus , protovirus and oncogene theories of neoplasia , and the immunoprophylaxis of RNA virus - induced tumors . - pubmed
[ The study of alkaline phosphatase and 5 - nucleotidase activity of peripheral neutrophils in severe pulmonary tuberculosis ] . - pubmed
Indirect hypoxanthine - guanine - phosphoribosyl transferase activity determination demonstrated a normal value , and thus the possibility of Lesch - Nyhan syndrome linked to the X - chromosome may be excluded . - pubmed
The authors study the amount of B cells and serum immunoglobulins in patients with mammary cancer or fibrocystic disease . - pubmed
Agents that block platelet glycoprotein IIb / IIIa integrin , the receptor that mediates the final common pathway of platelet aggregation , represent a promising new approach to preventing cardiovascular ischemic complications and late restenosis after percutaneous coronary revascularization . - pubmed
Ongoing trials are now exploring strategies for refining the practical aspects of glycoprotein IIb / IIIa therapy and minimizing the risk of bleeding . - pubmed
Consistently , the total free amino acid concentration in the gastrocnemius of insulin - treated rats 10 days after tumour transplantation was close to that of controls . - pubmed
Thyroglobulin antibodies in type 1 diabetic patients and their relatives -- measurement with highly sensitive assay . - pubmed
Autoimmunity in Type 1 ( insulin - dependent ) diabetes mellitus was assessed by measuring thyroglobulin antibodies ( TGA ) using a highly sensitive enzyme immunoassay in 65 young patients with Type 1 diabetes mellitus , 83 healthy first - degree relatives of the patients , 37 healthy control subjects and 67 healthy parents of the control subjects . - pubmed
These data suggest that H4 interacts with the insulin , rather than the hypoxia / contraction , pathway for activation of glucose transport in muscle tissue , and that H4 acts either directly or indirectly to increase the number of insulin receptors at the surface of the muscle cell . - pubmed
We found that induced sputum from asthmatic subjects had a higher percentage of eosinophils [ 8.1 + /- 3.43 ( mean + /- SEM ) versus 0.03 + /- 0.02 % , p & lt ; 0.009 ] ( after excluding squamous cells ) and also had higher levels of albumin ( 232.3 + /- 54.8 versus 79.5 + /- 9.7 micrograms / ml , p & lt ; 0.02 ) , fibrinogen ( 44.2 + /- 11.6 versus 11.9 + /- 2.5 micrograms / ml , p & lt ; 0.008 ) and eosinophil cationic protein ( ECP ) ( 142.6 + /- 34.2 versus 26.1 + /- 4.7 ng / ml , p & lt ; 0.006 ) but not of histamine or tryptase . - pubmed
BACKGROUND : Prostatic acid phosphatase ( PAP ) is an important protein which should be studied further as a tumor marker or as a biologically functional molecule . - pubmed
Translocation of glucokinase in pancreatic beta - cells during acute and chronic hyperglycemia . - pubmed
Glucokinase ( GK ) plays a key role in the regulation of glucose - induced insulin secretion , and questions have been raised about its relationship to the glucose transporter GLUT2 and its function in diabetes . - pubmed
GLUT2 staining was reduced overall , but variability between cells was observed , unlike the more uniform reductions seen with hyperglycemia of longer duration . - pubmed
Other rats received islet transplants to prevent hyperglycemia after Px ; their GK and GLUT2 staining patterns were normal . - pubmed
The translocation of this key enzyme for glucose recognition by beta - cells may lead to altered rates of insulin secretion during acute perturbations of fuel provision and in the diabetic state . - pubmed
A standardized hyperthyroid symptom score ( HSS ) and thyroid function tests including thyroid - stimulating hormone ( TSH ) , free thyroxine ( free T4 ) , free triiodothyronine ( free T3 ) , total thyroxine ( T4 ) and total triiodothyronine ( T3 ) were evaluated before and after 10 and 30 days of the study period . - pubmed
The Co ( 3 +)-insulin hexamer provides a novel prodrug approach to a soluble , prolonged - acting insulin preparation of potential use for basal insulin delivery in the treatment of diabetes . - pubmed
Hypertension risk increased with age , heart rate , serum triglycerides , insulin area , and obesity ( in young participants ) . - pubmed
Dysfunction of nitric oxide induces protein kinase C activation resulting in vasospasm after subarachnoid hemorrhage . - pubmed
We hypothesize that the interaction between protein kinase C ( PKC ) and nitric oxide ( NO ) plays a role in the modulation of cerebral vascular tone , and the disturbance of this interaction following subarachnoid hemorrhage ( SAH ) results in vasospasm . - pubmed
To prove this hypothesis with direct evidence , PKC activities of smooth muscle cells of canine basilar arteries in the control and in the SAH groups were measured by an enzyme immunoassay method . - pubmed
PKC activity in the SAH was significantly higher than in the control ; however , no further enhancement was produced with L - NA . - pubmed
In the SAH , PKC activity was not inhibited either by 8 - bromo - cGMP or SIN-1 . - pubmed
We conclude that NO maintains an appropriate vascular tone through inactivation of PKC , and that this effect is disturbed following SAH , resulting in PKC - dependent vascular contraction , such as vasospasm . - pubmed
When this study was repeated in the presence of LY83583 , a guanylate cyclase inhibitor , NP still produced cardiac depression in the presence of ISO . - pubmed
Previously , we have demonstrated the direct cytotoxicity of the bacterial toxins Pseudomonas aeruginosa exotoxin A ( Exo A ) and Salmonella enteritidis lipopolysaccharide ( LPS ) on pulmonary endothelial cells . - pubmed
Pretreatment of RAEC with db - cAMP ( 1 mM ) attenuated Exo A induced cytotoxicity . - pubmed
Defects in Bruton ' s tyrosine kinase ( Btk ) result in B cell immunodeficiencies in humans and mice . - pubmed
In a postmenopausal woman with a sonographically confirmed ovarian tumor , a progressively rising serum Ca-125 is highly suspicious for malignancy . - pubmed
Defective functional activity and accelerated apoptosis in neutrophils from children with cancer are differentially corrected by granulocyte and granulocyte - macrophage colony stimulating factors in vitro . - pubmed
In this study , PMN from children with cancer were evaluated to compare in vitro the corrective effects of the two myeloid colony stimulating factors G - CSF and GM - CSF on these defective pathways . - pubmed
Donepezil is a cholinesterase inhibitor used for the treatment of patients with mild to moderately severe Alzheimer ' s disease ( AD ) . - pubmed
We also studied the effects of IFN alpha on the cytotoxicity of the recombinant toxin TP40 which inhibits elongation factor 2 , another step of protein synthesis , through EGF - R binding and internalisation ; IFN alpha induced an about 27 - fold increase of TP40 cytotoxicity in KB cells . - pubmed
UNLABELLED : Calcium chloride ( CaCl ( 2 ) ) is ineffective in severe calcium channel antagonist overdoses . - pubmed
Serum IgM levels were significantly higher in patients with larger splenomegaly . - pubmed
We conclude that patients with subacute symptoms but without gross splenomegaly may have very high levels of IgM and malarial antibodies , and relapse on re - exposure , suggesting the existence of a variant of the hyperreactive malarial splenomegaly syndrome without gross splenomegaly . - pubmed
The B pocket of the class I major histocompatibility complex - encoded protein HLA - B * 2705 has recently been suggested to be responsible for the misfolding of this HLA haplotype and thus to induce susceptibility to autoimmune inflammatory diseases . - pubmed
HSP70 - peptide complex could activate lymphocytes to produce specific cytotoxicity to tumor cells , suggesting that the recombinant human HSP70 could be used as an antigen - presenting reagent in tumor therapy . - pubmed
We examined maternal concentrations of vascular endothelial growth factor and placental growth factor in normal pregnancies and in pregnancies that were complicated by isolated idiopathic small - for - gestational - age ( SGA ) newborn infants , preeclampsia alone , or preeclampsia with SGA newborn infants at the time of clinical disease and before the onset of clinical signs . - pubmed
RESULTS : In the cross - sectional study , serum placental growth factor was reduced in abnormal pregnancy relative to control subjects ( SGA newborn infants , 18 [ P = .04 ] ; preeclampsia , 20 ; or preeclampsia with small- for - gestational - age newborn infants , 11 [ P = .0001 ] ) as early as 15 to 19 weeks of gestation in preeclampsia with SGA newborn infants . - pubmed
Blocking both cytotoxic T - lymphocyte - associated antigen 4 ( CTLA-4 ) and CD28 interactions with a CTLA-4 / Ig fusion protein inhibits various immune - mediated processes in vivo , such as allograft rejection and autoimmunity . - pubmed
There have been major advances in the treatment of limited - stage SCLC during the past decade because of early application of thoracic radiation therapy ( TRT ) with concurrent chemotherapy , accelerated TRT , the application of prophylactic cranial irradiation for patients who achieved complete response to concurrent chemotherapy and TRT , and the improvement in supportive care such as discontinuation of tobacco smoking after the diagnosis of SCLC , nutritional support , pain control , granulocyte colony - stimulating factor , erythropoietin , and adequate antibiotics . - pubmed
Hence , 2OG is an intracellular indicator of nitrogen deficiency and acts as an inducer of nif transcription via NrpR. - pubmed
Inhibition of cell growth by overexpression of manganese superoxide dismutase ( MnSOD ) in human pancreatic carcinoma . - pubmed
Manganese superoxide dismutase ( MnSOD ) levels have been found to be low in human pancreatic cancer [ Pancreas 26 , ( 2003 ) , 23 ] and human pancreatic cancer cell lines [ Cancer Res . - pubmed
We hypothesized that stable overexpression of pancreatic cancer cells with MnSOD cDNA would alter the malignant phenotype . - pubmed
These results suggest that MnSOD may be a tumor suppressor gene in human pancreatic cancer . - pubmed
Cytokine gene polymorphisms and genetic association with coeliac disease in the Finnish population . - pubmed
We studied single - nucleotide polymorphisms in transforming growth factor ( TGF )- beta1 , interleukin ( IL )- 10 , IL-6 , interferon ( IFN )- gamma and tumour necrosis factor ( TNF)-alpha genes in the Finnish population using family - based association approach . - pubmed
We did not find evidence of association between TGF - beta1 , IL-10 , IL-6 and IFN - gamma polymorphisms and CD susceptibility . - pubmed
No association was found for any of the MICA alleles independently of DQ genes , whereas TNF - alpha-308 A allele was slightly overrepresented on chromosomes carried by CD patients compared with control chromosomes , indicating that either TNF - alpha , or another gene in linkage disequilibrium with it , could confer increased susceptibility to CD . - pubmed
Elevated monocyte chemoattractant protein-1 serum levels in patients at risk for coronary artery disease . - pubmed
BACKGROUND : Monocyte chemoattractant protein-1 ( MCP-1 ) is involved in the recruitment of monocytes into the arterial vessel wall as one of the major events leading to atherosclerotic vascular diseases , such as coronary artery disease ( CAD ) . - pubmed
Patients with CAD proven by angiography had significantly increased MCP-1 levels . - pubmed
In patients without CAD , the increase in MCP-1 depended on the number of CRF . - pubmed
As a marker for endothelial activation the soluble adhesion molecules , soluble intercellular adhesion molecule and soluble E - selectin were measured and both markers were significantly elevated in patients with CAD or multiple CRF when compared with patients without CRF . - pubmed
Although this is not a direct proof , endothelial activation could contribute to elevated MCP-1 levels in atherosclerosis . - pubmed
CONCLUSION : Elevated MCP-1 serum levels could serve as a direct marker of the inflammatory activity in patients at risk for coronary artery and other atherosclerotic vascular diseases . - pubmed
One of the mechanisms involved in the progression of diabetic nephropathy , the most common cause of end - stage renal failure , is angiogenic phenomenon associated with the increase of angiogenic factors such as vascular endothelial growth factor ( VEGF )- A and angiopoietin ( Ang )- 2 , an antagonist of Ang-1 . - pubmed
[ Cytotoxic T lymphocyte antigen-4 promoter gene polymorphism is significantly associated with ulcerative colitis ] . - pubmed
The aim of the present study is to investigate the association between CTLA-4 promoter -1722 ( T / C ) , -1661 ( A / G ) polymorphisms and ulcerative colitis ( UC ) in Han Chinese , in Hubei province of central China . - pubmed
METHODS : Eighty - seven patients with UC and 116 healthy controls were genotyped for CTLA-4 promoter -1722 and -1661 polymorphisms with a method of polymerase chain reaction based restriction fragment length polymorphism . - pubmed
CONCLUSION : The G allele of CTLA-4 promoter -1661 polymorphism showed a highly significant association with UC in Han Chinese of the central China . - pubmed
The clinical and laboratory response to recombinant factor VIIA in trauma and surgical patients with acquired coagulopathy . - pubmed
OBJECTIVE : In bleeding patients who are coagulopathic , the clinical response to administration of recombinant factor VIIa ( rFVIIa ) relates to the changes in prothrombin time ( PT ) . - pubmed
DESIGN : Retrospective review of all surgical and trauma patients who were coagulopathic and received factor VIIa at the authors ' institution over the past 27 months . - pubmed
There were no significant differences in percentage PT decrease between dose & gt ; or = 100 mcg / kg vs & lt;100 mcg / kg , surgical vs trauma patients , survivors vs nonsurvivors , and those with pretreatment platelet count & gt ; or = 100 K vs & lt;100 K. CONCLUSIONS : The administration of rFVIIa caused a decrease in the PT in nearly all patients . - pubmed
Barth syndrome ( BTHS ) is a mitochondrial disorder that is caused by mutations in the tafazzin gene , which affects phospholipid composition . - pubmed
SUPPORTING EVIDENCE FOR THE HYPOTHESIS : This hypothesis results from previous studies showing that IgG1 and IgG3 responses against antigens like ring - infected erythrocyte surface antigens , merozoite surface proteins and variant surface antigens on schizonts were associated with clinical immunity against malaria . - pubmed
The resulting pattern of responses for each immunoglobulin isotype could be compared between clinically immune participants remaining asymptomatic with subsequent P. - pubmed
These mutants were characterized in an optimized T - cell factor ( TCF)-luciferase based assay in U2OS human osteosarcoma cells . - pubmed
Pharmacological agents such as statins and angiotensin - converting enzyme inhibitors may promote tissue stabilization in AAA by diminishing pro - inflammatory signaling and normalizing metabolism of the ECM . - pubmed
Our recent experiments in animal models demonstrate that inhibition of c - Jun N terminal kinase ( JNK ) inhibits multiple pathological processes and causes regression of established AAA . - pubmed
CONCLUSION : Most women have antibodies to HSV-1 , which is partially protective against HSV-2 infection . - pubmed
Small molecules inhibiting the proliferative cascade of the cancer cells and monoclonal specific antibodies against growth factor or vascular endothelial growth factor have been claimed as the promise in cancer therapy . - pubmed
Donor CTLA-4 +49 A / G*GG genotype is associated with chronic GVHD after HLA - identical haematopoietic stem - cell transplantations . - pubmed
Apolipoproteins B and AI and the risk of ischemic cerebrovascular events in patients with pre - existing atherothrombotic disease . - pubmed
We examined the association between serum concentrations of Apo B , Apo A - I , and the Apo A - I / Apo B ratio and the risk of incident ischemic cerebrovascular events in patients with pre - existing atherothrombotic disease . - pubmed
METHODS : Patients with documented chronic coronary heart disease and measured Apo B and Apo A - I concentration , screened for but not included in a clinical trial of lipid modification were followed over 4.8 to 8.1 years for hospitalized incident cerebrovascular events . - pubmed
Adjusting for potential confounders , the hazard ratios ( HR ) for incident ischemic cerebrovascular events associated with the top versus bottom quartile of Apo B was 1.68 ( 95%CI , 1.18 - 2.40 ) , of Apo A - I 0.71 ( 95%CI , 0.50 - 1.00 ) , and of Apo A - I / Apo B ratio 0.51 ( 95%CI , 0.35 - 0.74 ) . - pubmed
CONCLUSIONS : These findings support the hypothesis that Apo B , Apo A - I and the Apo A - I / Apo B ratio predict incident ischemic stroke among patients with preexisting atherothrombotic disease . - pubmed
The potential clinical role of measuring these apolipoproteins for ischemic stroke prediction warrants further study . - pubmed
Humans exposed prenatally to ethanol can exhibit brain abnormalities and cognitive impairment similar to those seen in patients expressing mutant forms of the L1 cell adhesion molecule ( L1CAM ) . - pubmed
BACKGROUND : Serum copper not bound to ceruloplasmin ( " free " ) appears slightly elevated in patients with Alzheimer disease ( AD ) . - pubmed
METHODS : We assessed levels of copper , iron , zinc , transferrin , ceruloplasmin , peroxides , total antioxidant capacity , free copper , and apolipoprotein E genotype in 81 patients with mild or moderate AD , mean age 74.4 , SD = 7.4 years , clinically followed up after 1 year . - pubmed
Effect of antisense oligomer in controlling c - raf.1 overexpression during diethylnitrosamine - induced hepatocarcinogenesis in rat . - pubmed
PURPOSE : In ras - mediated signal transduction pathway , c - raf.1 is believed to have predominant oncogenic potential and has been found to be highly expressed in certain human and animal malignancies including hepatocellular carcinoma . - pubmed
RESULTS : c - raf.1 antisense oligomers exhibited an inhibitory effect ( approximately 68 % ) on cancer cell proliferation in vitro . - pubmed
CONCLUSION : The study demonstrates that the antisense oligomer targeted against c - raf.1 mRNA inhibits the overexpression of c - raf.1 gene during hepatocellular carcinoma in rats . - pubmed
However , we find that this homeostatic mechanism can lead to massive over - proliferation of intestinal cells when infection occurs in animals with a latent oncogenic form of the Ras1 oncogene . - pubmed
Treatment consists of an angiotensin - converting enzyme inhibitor and/or beta blocker if needed for left ventricular dysfunction and possibly an anxiolytic agent . - pubmed
AIM OF THE STUDY : Rheumatoid arthritis synovial fibroblasts ( RASFs ) are known to produce matrix metalloproteinases ( MMPs ) and cause joint destruction . - pubmed
The anti - CD20 monoclonal antibody rituximab is an effective treatment for small lymphocytic lymphoma ; however , it has been associated with infusion reactions , including cardiac arrhythmias . - pubmed
METHODS : The expression levels of h - TERT , CK20 , CEA , and C - MET were detected in a model of circulating micrometastasis in pancreatic cancer that were enriched using immune - magnetic separation of the circulating cancer cells . - pubmed
The positive expression rates of C - MET , h - TERT , CK20 , and CEA in the pancreatic cancer group were 80 % ( 20/25 ) , 100 % ( 25/25 ) , 84 % ( 21/25 ) , and 80 % ( 20/25 ) , respectively , while in the benign disease control group the rates were 0 % ( 0/15 ) , 0 % ( 0/15 ) , 6.77 % ( 1/15 ) , and 0 % ( 0/15 ) , respectively . - pubmed
The positive expression rate of the four genes was not related to gender , age , tumor size , CA 19 - 9 , or CEA serum levels ( P>0.05 ) . - pubmed
However , the positive expression of C - MET , CK20 , and CEA closely correlated with tumor stage ( P<0.05 ) . - pubmed
CONCLUSIONS : The positive expression of C - MET , h - TERT , CK20 , and CEA in the circulation of pancreatic patients could be used as an indicator for circulating cancer cells . - pubmed
CONCLUSION : Retracted musculotendinous units have deteriorated tendons , characterized by increased collagen fiber crimp , and ultrastructural collagen fibril atrophy and disorganization . - pubmed
For secondary prevention , high triglycerides or low HDL - C , but not LDL - C , significantly increased the relative risk of cardiac events in the patients with complication of cardiac disease . - pubmed
CONCLUSIONS : The LEM study , a large - scale prospective study of long - term fluvastatin treatment for hypercholesterolemia in Japanese patients , demonstrated high impact of complications such as DM and hypertension as well as high triglycerides or low HDL - C on cardiac and cerebral events . - pubmed
The aim of this study was to identify the alterations in N - glycans in human OA cartilage , to characterize the messenger RNA ( mRNA ) expression of N - glycan biosynthesis enzyme genes ( N - glycogenes ) in mouse articular chondrocytes during cartilage degradation , and to analyze the relationship between altered N - glycan patterns and mechanisms of cartilage degradation . - pubmed
dexamethasone , preoperative administration of analgesia including the use of non - steroidal anti - inflammatory or COX II inhibitors , intraoperative use of an anti - emetic , pre - incisional use of bupivacaine , administration of intraperitoneal bupivacaine on establishment of pneumoperitoneum , and avoidance of drains . - pubmed
OPA1 mutations in Japanese patients suspected to have autosomal dominant optic atrophy . - pubmed
PURPOSE : To report three types of heterozygous mutations in the OPA1 gene in five patients from three families with autosomal dominant optic atrophy ( ADOA , MIM#165500 ) . - pubmed
CONCLUSION : OPA1 mutations existed in three Japanese families with ADOA . - pubmed
After a detailed clinical assessment of the proband , the screening of the OPA1 gene may be helpful for precise diagnosis of ADOA , provided the relevant information of the family members is limited . - pubmed
Concurrent CIC mutations , IDH mutations , and 1p/19q loss distinguish oligodendrogliomas from other cancers . - pubmed
In addition , we discovered somatic mutations and insertions / deletions in the CIC gene on chromosome 19q13.2 in 13/16 tumours . - pubmed
CIC mutations were highly associated with oligodendroglioma histology , 1p/19q co - deletion , and IDH1/2 mutation ( p & lt ; 0.001 ) . - pubmed
We hypothesize that the mutant CIC on the single retained 19q allele is linked to the pathogenesis of oligodendrogliomas with IDH mutation . - pubmed
Our detailed study of genetic aberrations in oligodendroglioma suggests a functional interaction between CIC mutation , IDH1 / 2 mutation , and 1p/19q co - deletion . - pubmed
Since the rough strain Brucella melitensis B115 was able to protect mice against wild Brucella strains brucellosis despite the lack of anti - OPS antibodies , in this study we evaluated the biological significance of antibodies induced by this strain , directed to antigens other than O - PS , passively tranferred to untreated mice prior to infection with Brucella abortus 2308 and B. - pubmed
Airway inflammation induced by CS was demonstrated by pathologic changes of lung tissue and increased level of CXCL-8 . - pubmed
Moreover , a negative correlation was found between HDAC-2 activity and a lung destruction index . - pubmed
These results indicate that low - dose theophylline might provide protection from smoke damage and improve the anti - inflammatory effects of steroids by increasing HDAC-2 activity . - pubmed
FOXA1 promotes tumor progression in prostate cancer via the insulin - like growth factor binding protein 3 pathway . - pubmed
However , the precise role of FOXA1 in prostate cancer ( PC ) remains unknown . - pubmed
In this study , we report that FOXA1 plays a critical role in PC cell proliferation . - pubmed
The expression of FOXA1 was higher in PC than in normal prostate tissues ( P = 0.0002 ) , and , using immunohistochemical analysis , we found that FOXA1 was localized in the nucleus . - pubmed
Depletion of FOXA1 in a prostate cancer cell line ( LNCaP ) using small interfering RNA ( siRNA ) significantly inhibited AR activity , led to cell - growth suppression , and induced G0 / G1 arrest . - pubmed
These findings provide direct physiological and molecular evidence for a role of FOXA1 in controlling cell proliferation through the regulation of IGFBP-3 expression in PC . - pubmed
The disruption of sucrose movement in the phloem in tdy2 mutants provides evidence that the Tdy2 callose synthase functions in vascular maturation and that the vascular defects result in impaired symplastic trafficking into the phloem translocation stream . - pubmed
The use of CD138 positively selected marrow samples increases the applicability of minimal residual disease assessment by PCR in patients with multiple myeloma . - pubmed
We have evaluated the use of CD138 + positively selected bone marrow samples to identify a molecular target for minimal residual disease assessment by polymerase chain reaction ( PCR ) in 25 untreated patients with multiple myeloma . - pubmed
We conclude that the use of CD138 + positively selected bone marrow samples increases the applicability of minimal residual disease studies by PCR in patients with multiple myeloma . - pubmed
Combination of recombinant factor VIIa and fibrinogen corrects clot formation in primary immune thrombocytopenia at very low platelet counts . - pubmed
This study challenged the hypothesis that recombinant activated factor VII ( rFVIIa ) combined with fibrinogen concentrate may correct whole blood ( WB ) clot formation in ITP . - pubmed
Blood from ITP patients ( n = 12 ) was drawn into tubes containing 3 2 % citrate and corn trypsin inhibitor 18 3 mug / ml . - pubmed
These data suggest that rFVIIa combined with fibrinogen corrects the coagulopathy of ITP even at very low platelet counts , and may represent an alternative to platelet transfusion . - pubmed
Role of the TNFA -308 G & gt ; A polymorphism in the genetic susceptibility to acne vulgaris in a Sicilian population . - pubmed
The aim of the present study was to investigate whether TNFA -308 G & gt ; A polymorphism might be involved in the pathogenesis of acne in a population from Sicily . - pubmed
A significant protective association between the TNFA -308 GA genotype and acne in males ( p = 0.027 ; OR95 % CI : 0.288 ; 0.094 - 0.889 ) was shown . - pubmed
CONCLUSIONS : The present results suggest that TNFA -308 polymorphism may contribute to acne susceptibility , as suggested by the protective effect of the G / A phenotype in the males of the Sicilian cohort . - pubmed
Further studies in larger groups , investigating the TNFA -308G / A or other polymorphisms of this gene in acne patients may be helpful to clarify the pathogenesis of the disease . - pubmed
The proprotein convertases ( PCs ) are serine proteases responsible for the proteolytic maturation of many precursor proteins involved in upper airway remodelling during nasal polyposis . - pubmed
However , whether PC1 / 3 is related to nasal polyp formation has not been investigated . - pubmed
To gain insight into the functional role of PC1 / 3 in nasal polyps , we determined PC1 / 3 expression in nasal polyps by immunostaining , Western blotting and enzyme assays and generated stable cells expressing PC1 / 3 using airway epithelial cell line NCI - H292 . - pubmed
Nasal polyps exhibit increased PC1 / 3 expression compared to normal nasal mucosa . - pubmed
PC1 / 3 was expressed in neuroendocrine cells in normal nasal mucosa and it was also expressed in goblet and ciliated cells in nasal polyps . - pubmed
Importantly , PC1 / 3 expression was positively correlated with epithelial - mesenchymal transition in cultured human nasal epithelial cells and in nasal polyps . - pubmed
Taken together , our data suggest that PC1 / 3 overexpression induces morphological and phenotypic epithelial - mesenchymal transition changes of airway epithelial cells and these changes may contribute to the pathogenesis of nasal polyps . - pubmed
Although transplantation of c - kit+ cardiac stem cells ( CSCs ) alleviates post - myocardial infarction left ventricular dysfunction , there are no reliable methods that enable measurement of the absolute number of CSCs that persist in the recipient heart . - pubmed
CNTNAP2 is a gene on chromosome 7 that has shown associations with autism and schizophrenia , and there is evidence that it plays an important role for neuronal synchronization and brain connectivity . - pubmed
81 healthy controls and 44 patients with schizophrenia ( all Caucasian ) underwent DTI and genotyping of 31 SNPs within CNTNAP2 . - pubmed
We present new evidence about the effects of CNTNAP2 on brain connectivity , whose disruption has been hypothesized to be central to schizophrenia pathophysiology . - pubmed
Preclinical studies of a specific PPARgamma modulator in the control of skin inflammation . - pubmed
Consistently , PPARgamma agonists have been proposed in various inflammatory skin disorders , but their wide use has been limited by severe side effects . - pubmed
In psoriasis - like skin lesions elicited in mice by IL-21 , topical application of GED-0507 - 34L reduced cellular infiltrate and epidermal hyperplasia , normalizing the differentiation process . - pubmed
[ A comparative study of the effects of needle free ( INJEX30 ) versus insulin pen injection on insulin absorption in diabetic patients ] . - pubmed
OBJECTIVE : To evaluate the effect of the needle free injection system ( INJEX30 ) and insulin pen on insulin absorption and glycemic control in diabetic patients . - pubmed
METHODS : A total of 30 diabetic patients on insulin therapy without obvious complications were enrolled in the study with average BMI of 25.24 kg / m(2 ) . - pubmed
Iron - deficiency anemia and diabetes mellitus were associated with a very high TPMT activity ( p = 0.0004 and p = 0.0015 , respectively ) . - pubmed
Protein kinase inhibitors to treat non - small - cell lung cancer . - pubmed
INTRODUCTION : Activating mutations of the EGFR and rearrangement of anaplastic lymphoma kinase ( ALK ) best illustrate the therapeutic relevance of molecular characterization in NSCLC patients . - pubmed
AREAS COVERED : For this review article , all published data on the most relevant Phase III trials with tyrosine kinase inhibitors ( TKIs ) for the treatment of NSCLC were collected and analyzed . - pubmed
In pretreated NSCLC , EGFR TKIs are considered more effective than standard monotherapy with cytotoxics in presence of classical EGFR mutations , whereas in the EGFR wild - type population , a similar efficacy to docetaxel or pemetrexed in term of survival has been demonstrated . - pubmed
In ALK - translocated NSCLC , a Phase III trial demonstrated the superiority of a multi - target TKI , including ALK , in terms of progression - free survival , response rate and toxicity profile when compared to standard second - line chemotherapy . - pubmed
Screening of diabetes of youth for hepatocyte nuclear factor 1 mutations : clinical phenotype of HNF1beta - related maturity - onset diabetes of the young and HNF1alpha - related maturity - onset diabetes of the young in Japanese . - pubmed
AIM : To compare the prevalence and clinical features of HNF1beta - related MODY and HNF1alpha - related MODY in Japanese . - pubmed
METHODS : We enrolled 230 Japanese patients with suspected MODY and examined them for HNF1alpha and HNF1beta mutations . - pubmed
We characterized the clinical features of HNF1beta - related MODY ( HNF1beta - MODY ) and HNF1alpha - related MODY ( HNF1alpha - MODY ) . - pubmed
Five of the patients with HNF1beta - MODY had insulin secretion defects and were treated with insulin , and four of these did not have a parent with overt diabetes . - pubmed
CONCLUSION : HNF1beta - MODY may present as beta - cell dysfunction in Japanese rather than as hyperinsulinaemia , which it does among European / American . - pubmed
Urinary neutrophil gelatinase - associated lipocalin as an early predictor of disease severity and mortality in acute pancreatitis . - pubmed
The aim of the study was to assess whether urinary level of neutrophil gelatinase - associated lipocalin ( NGAL ) could represent a useful marker of AP severity . - pubmed
CONCLUSIONS : The urinary level of NGAL is a promising new diagnostic and prognostic factor for severe AP in an early stage of the disease . - pubmed
Recent research supposes endocan as a biomarker for evaluating cardiovascular events , inflammatory diseases , and cancers . - pubmed
propose serum endocan levels as a novel prediction marker of all - cause mortality and cardiovascular events in CKD patients . - pubmed
TRPML1 has been associated with mucolipidosis type IV ( MLIV ) , while no disease phenotype has been linked with TRPML2 or - 3 protein . - pubmed
In summary , these data indicate cell - communication associated with three - dimensional islet architecture is important both for effective insulin secretion and for protection of human beta cells against cytotoxicity . - pubmed
Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30 knockout mice . - pubmed
AIM : Secondary necrotic cells generated in vivo induce inflammatory responses ; for example , the production of macrophage inflammatory protein-2 ( MIP-2 ) and subsequent infiltration of neutrophils . - pubmed
METHODS : The phagocytosis of secondary necrotic neutrophils with resident macrophage from either WT young mice , WT aged mice or SMP30(-/- ) mice was examined by coculturing macrophages with secondary necrotic neutrophils in vitro . - pubmed
To investigate the inflammatory response induced by secondary necrotic cells , time - dependent infiltration of neutrophils and production of MIP-2 were determined in the peritoneal cavity on the injection of secondary necrotic cells . - pubmed
On peritoneal injection of secondary necrotic cells , the peak time of neutrophil infiltration was earlier in SMP30(-/- ) mice than in WT young mice . - pubmed
CONCLUSIONS : Our findings showed that the phagocytosis of secondary necrotic cells was attenuated in aged mice and SMP30 (-/- ) mice , and that the MIP-2 production was enhanced and subsequently neutrophil infiltration was exaggerated on peritoneal injection of secondary necrotic cells into those mice . - pubmed
We describe recent findings that associate Activin / Nodal signalling to pathological conditions , focusing on cancer stem cells in tumorigenesis and its potential as a target for therapies . - pubmed
Previous studies in vanadium toxicity showed involvement of oxidative stress in isolated liver hepatocytes and mitochondria via increasing of ROS formation , release of cytochrome c and ATP depletion after incubation with different concentrations ( 25 - 200 microM ) . - pubmed
Adding MRI to annual mammography screening improves early breast cancer detection in women with familial risk or BRCA1 / 2 mutation , but breast cancer specific metastasis free survival ( MFS ) remains unknown . - pubmed
Of 2,308 MRISC participants , breast cancer was detected in 93 ( 97 breast cancers ) , who received MRI & lt;2 years before breast cancer diagnosis ; 33 BRCA1 mutation carriers , 18 BRCA2 mutation carriers , and 42 with familial risk . - pubmed
MFS was better in MRISC patients overall ( log - rank p = 0.008 , HR 0.36 , 95 % CI 0.16 - 0.80 ) , with familial risk ( log - rank p = 0.024 , HR : 0.21 , 95 % CI 0.04 - 0.95 ) , and in BRCA1 mutation carriers ( log - rank p = 0.055 , HR 0.30 , 95 % CI 0.08 - 1.13 ) . - pubmed
Anti - E1E2 antibodies do predict response to triple therapy in treatment - experienced Hepatitis C Virus - cirrhosis cases . - pubmed
BACKGROUND AND AIMS : We previously showed that pre - treatment serum anti - E1E2 predicted hepatitis C virus ( HCV ) RNA viral kinetics ( VKs ) and treatment outcome in patients with chronic hepatitis C receiving pegylated interferon / ribavirin ( Peg - IFN / RBV ) double therapy . - pubmed
Here , we determined whether baseline anti - E1E2 was correlated with the on - treatment VK and could predict virological outcome in treatment - experienced HCV - infected cirrhotic patients receiving protease inhibitor - based triple therapy . - pubmed
Rapamycin , an mTOR inhibitor , induced apoptosis via independent mitochondrial and death receptor pathway in retinoblastoma Y79 cell . - pubmed
Rapamycin is helpful in the treatment of certain cancers by inhibiting mTOR ( mammalian target of rapamycin ) pathway . - pubmed
Hepatoma - derived Growth Factor Predicts Disease Severity and Survival in Pulmonary Arterial Hypertension . - pubmed
OBJECTIVES : We sought to assess the relationship of serum hepatoma - derived growth factor ( HDGF ) with PAH disease severity and survival . - pubmed
Importantly , serum HDGF levels were not elevated in a noncardiac chronic disease cohort . - pubmed
CONCLUSIONS : Elevated HDGF was associated with worse functional class , exertional intolerance , and increased mortality in PAH , suggesting HDGF as a potential biomarker for predicting mortality and as having possible diagnostic value for distinguishing PAH from non - PAH . - pubmed
HDGF may add additional value in PAH risk stratification in clinical trials and may represent a potential target for future PAH drug development . - pubmed
There is very little direct research to conclusively prove the relevance of diet in primary tendinopathies , however it seems prudent to ask whether our current knowledge about the impact of nutrition on collagen metabolism could be useful in assessing , preventing , or treating tendinopathy . - pubmed
These can be detected immunohistochemically using anti - CD138 antibodies , which should be carried out particularly in cases of infertility with only slight inflammatory symptoms and few plasma cells . - pubmed
In contrast to pancreatic and gastric cancer patients , CRC subjects presented neither an increase in the number of circulating SCs nor the activation of pro - mobilizing factors such as complement , coagulation and fibrinolytic cascade , circulating stromal derived factor 1 ( SDF-1 ) , vascular endothelial growth factor ( VEGF ) and intestinal permeability marker ( zonulin ) . - pubmed
METHODS : Preoperative lipid levels ( total cholesterol , LDL cholesterol , HDL cholesterol and triglycerides ) and statin use from consecutive patients with clinically localized PCa undergoing RP in a tertiary referral center between 2008 and 2015 were recorded and patients were followed prospectively . - pubmed
Preoperative LDL cholesterol remained an independent predictor for PCa recurrence in a multivariable model adjusted for age , preoperative PSA , statin use , tumor stage , Gleason score , nodal status and surgical margin status ( continuous : HR : 0.66 , 95%-CI : 0.44 - 0.99 , P = 0.04 ; 3 mM cut - point : HR : 0.41 , 95%-CI : 0.21 - 0.78 , P = 0.007 ) . - pubmed
CONCLUSIONS : This is the first prospective study showing the potential adverse and independent prognostic role of low preoperative LDL cholesterol levels in patients with localized PCa undergoing RP . - pubmed
After adjusting for maturation and ethnicity , indirect measures of adiposity accounted for 29 - 34 % in HOMA - IR , 10 - 13 % in TG , 14 - 17 % in HDL - C , and 5 - 8 % in LDL - C while direct measures accounted for 29 - 34 % in HOMA - IR , 10 - 12 % in TG , 13 - 16 % in HDL - C , and 5 - 6 % in LDL - C. The addition of direct measures of adiposity to indirect measures added significantly to the variance explained for HOMA - IR ( p = 0.04 ) . - pubmed
Knockdown of mediator subunit Med19 suppresses bladder cancer cell proliferation and migration by downregulating Wnt / beta - catenin signalling pathway . - pubmed
Mediator complex subunit 19 ( Med19 ) , a RNA polymerase II - embedded coactivator , is reported to be involved in bladder cancer ( BCa ) progression , but its functional contribution to this process is poorly understood . - pubmed
Med19 expression in 15 BCa tissues was significantly higher than adjacent paired normal tissues using real - time PCR and Western blot analysis . - pubmed
Immunohistochemical staining of 167 paraffin - embedded BCa tissues was performed , and the results showed that high Med19 protein level was positively correlated with clinical stages and histopathological grade . - pubmed
Functional assays showed that knocking - down of Med19 can suppress cell proliferation and migration in T24 , UM - UC3 cells and 5637 in vitro , and inhibited BCa tumour growth in vivo . - pubmed
Our data suggest that Med19 expression correlates with aggressive characteristics of BCa and Med19 knockdown suppresses the proliferation and migration of BCa cells through down - regulating the Wnt / beta - catenin pathway , thereby highlighting Med19 as a potential therapeutic target for BCa treatment . - pubmed
In this study , we found that hypoxia could promote umbilical cord mesenchymal stem cells ( UCMSCs ) differentiation into ATII cells rather than into fibroblast - like cells , and this effect was mainly mediated by microRNA-145 ( miR-145 ) , which could induce the inhibition of TGF - beta signaling by targeting TGF - beta receptor II ( TGFbetaRII ) . - pubmed
Quadruple immunotherapy of Bacillus Calmette - Guerin , interferon , interleukin-2 , and granulocyte - macrophage colony - stimulating factor as salvage therapy for non - muscle - invasive bladder cancer . - pubmed
ERCC1 expression status predicts the response and survival of patients with metastatic or recurrent cervical cancer treated via platinum - based chemotherapy . - pubmed
Our aim was to explore whether ERCC1 expression predicted tumor response and survival in patients with recurrent or metastatic cervical cancer treated via platinum - based chemotherapy . - pubmed
The median progression - free survival differed significantly by ERCC1 status , being 135 days in ERCC1 - high and 242 days in ERCC1 - low patients ( hazard ratio , 2.428 ; 95 % confidence interval , 1.145 - 5.148 , P = .032 ) . - pubmed
Thus , pretreatment ERCC1 expression status can be used to predict tumor response and survival of patients with recurrent or metastatic uterine cervical cancer receiving platinum - based chemotherapy . - pubmed
Our results showed marked increase in all measured parameters except SOD , TAC , eNOS immunoexpression and Bcl2 mRNA gene expression which decreased in Cd induced hepatotoxicity group . - pubmed
The natural course of classical diabetic nephropathy is initially microalbuminuria or moderately increased urine albumin excretion ( 30 - 300mg / g creatinine ) . - pubmed
The frequency and magnitude of anti - LT toxin , CFA / I and LPS O78 immune responses were antigen , dose , severity of diarrhea and shedding levels dependent . - pubmed
Carboplatin in BRCA1 / 2 - mutated and triple - negative breast cancer BRCAness subgroups : the TNT Trial . - pubmed
Germline mutations in BRCA1 / 2 predispose individuals to breast cancer ( termed germline - mutated BRCA1 / 2 breast cancer , gBRCA - BC ) by impairing homologous recombination ( HR ) and causing genomic instability . - pubmed
HR also repairs DNA lesions caused by platinum agents and PARP inhibitors . - pubmed
Triple - negative breast cancers ( TNBCs ) harbor subpopulations with BRCA1 / 2 mutations , hypothesized to be especially platinum - sensitive . - pubmed
Cancers in putative ' BRCAness ' subgroups - tumors with BRCA1 methylation ; low levels of BRCA1 mRNA ( BRCA1 mRNA - low ) ; or mutational signatures for HR deficiency and those with basal phenotypes - may also be sensitive to platinum . - pubmed
Such benefit was not observed for subjects with BRCA1 methylation , BRCA1 mRNA - low tumors or a high score in a Myriad HRD assay . - pubmed
We conclude that patients with advanced TNBC benefit from characterization of BRCA1 / 2 mutations , but not BRCA1 methylation or Myriad HRD analyses , to inform choices on platinum - based chemotherapy . - pubmed
Hypotension , but not the increase in colorectal pressure , was inhibited by a 10 - min pretreatment with the NK1 receptor antagonist CP-99,994 . - pubmed
miR-665 promotes hepatocellular carcinoma cell migration , invasion , and proliferation by decreasing Hippo signaling through targeting PTPRB . - pubmed
Tyrosine phosphatase receptor type B ( PTPRB ) was downregulated in HCC tissues , and was negatively correlated with miR-665 expression . - pubmed
Restoration of PTPRB reverses the effects of miR-665 on HCC migration , invasion , and cell proliferation . - pubmed
In conclusion , our results suggested that miR-665 was a negative regulator of the PTPRB and could promote tumor proliferation and metastasis in HCC through decreasing Hippo signaling pathway activity , which can be a potential target for HCC treatment . - pubmed
While glimepiride stimulates beta - cell secretion and leads to a reduction of blood glucose levels , pioglitazone activates peroxisome proliferator - activated receptor - gamma and improves insulin resistance . - pubmed
The Combined Use of Phenothiazines and Statins Strongly Affects Doxorubicin - Resistance , Apoptosis , and Cox-2 Activity in Colon Cancer Cells . - pubmed
The effect of three phenothiazine derivatives that were used as single agents and in combination with simvastatin on cell growth , apoptosis induction , activity , and expression of cyclooxygenase-2 ( COX-2 ) in doxorubicin - resistant colon cancer cells ( LoVo / Dx ) was investigated . - pubmed
UTX ( also known as KDM6A ) , a histone 3 lysine 27 demethylase , is among the most frequently mutated epigenetic regulators in myelodysplastic syndrome ( MDS ) and acute myeloid leukemia ( AML ) . - pubmed
Recent studies have suggested that UTX mutations promote MDS and AML by blocking the differentiation of hematopoietic stem and progenitor cells ( HSPCs ) . - pubmed
Further , SP2509 promoted the differentiation of Utx - null AML cells in vitro and in vivo and , therefore , extended the survival of these leukemic mice . - pubmed
Thus , our study identified a novel strategy to specifically target both premalignant and malignant cells with Utx deficiency for differentiation therapy and provided insights into the molecular mechanisms underlying the role of Utx in regulating HSPCs and related diseases . - pubmed
The laboratory results revealed WBC count of 20.6 x 103 / mm3 ( 76.9 % neutrophils ) , CRP ( c - reactive protein ) of 33 mg / L and erythrocyte sedimentation of 110 / h. The patient was referred to a dermatologist with prediagnosis of SS due to the presence of typical painful skin lesions , high fever and neutrophilic leukocytosis . - pubmed
The aim of our study was to evaluate the effect of ancestral TCDD exposure on ovarian toxicity in offspring rats ( F3 ) , focusing on the Igf2 / H19 pathway which was important for follicular development . - pubmed
The successful in vitro and in vivo delivery of siRNA , as well as targeted gene knockdown potential , was demonstrated by HDAC4 inhibition in vitro diabetic nephropathy ( DN ) podocyte model as well as in vivo DN C57BL / 6 mice model . - pubmed
japonicum extract exhibits antidepressant - like activity in CORT - induced depressive mice , which might be as a result of increased BDNF expression . - pubmed
The purpose of this article is to review and investigate further the molecular mechanism by which the SARS - CoV2 virus infection proceeds via the formation of a hetero - trimer between its protein S , the ACE2 receptor and the B0AT1 protein , which is the " entry receptor " for the infection process involving membrane fusion ( Li et al . - pubmed
Although the mechanisms of action underlying the glucose - lowering properties of HCQ are still not entirely clear , evidence suggests that this drug may exert multifaceted effects on glucose regulation , including improvement of insulin sensitivity , increase of insulin secretion , reduction of hepatic insulin clearance , and reduction of systemic inflammation . - pubmed
Letter to the editor : " Comment on : Application of the optimized carbon monoxide rebreathing method for the measurement of total haemoglobin mass in chronic liver disease " . - pubmed
Synovial sarcoma , malignant peripheral nerve sheath tumor ( MPNST ) , and pleuropulmonary blastoma also express CD56 . - pubmed
Pharmacokinetic samples , peripheral blood CD56 - positive cell counts , and tumor CD56 expression were assessed . - pubmed
Five patients experienced 9 dose - limiting toxicities : hyperglycemia ( n = 1 ) , colonic fistula ( n = 1 ) with perforation ( n = 1 ) , nausea ( n = 1 ) with vomiting ( n = 1 ) , increased alanine aminotransferase in cycle 1 ( n = 2 ) , and increased alanine aminotransferase in cycle 2 ( n = 1 ) with increased aspartate aminotransferase ( n = 1 ) . - pubmed
Increasing evidences indicate that in Myotonic Dystrophy type 1 ( DM1 or Steinert disease ) , an autosomal dominant multisystem disorder caused by a ( CTG)n expansion in DMPK gene on chromosome 19q13 . - pubmed
Apolipoprotein A2 Isoforms : New Insight into the Risk of Myocardial Infarction . - pubmed
Further , the molecular interactions between erythrin and the diabetes related target proteins was established by analysing the interactions with associated amino acids . - pubmed
Analysis of steatosis biomarkers and inflammatory profile after adding on PCSK9 inhibitor treatment in familial hypercholesterolemia subjects with nonalcoholic fatty liver disease : A single lipid center real - world experience . - pubmed
We aimed to evaluate the effect of the inhibitors of proprotein convertase subtilisin / kexin type 9 ( PCSK9 - i ) on steatosis biomarkers such as triglyceride - glucose index ( TyG ) and hepatic steatosis index ( HSI ) and analyse the role of TG / HDL in this population before and after adding - on PCSK9 - i. - pubmed
METHODS AND RESULTS : In this observational study , we evaluated 26 genetically confirmed FH patients with NAFLD and an LDL - C off - target despite high - intensity statins plus ezetimibe . - pubmed
No difference of steatosis biomarkers was found after adding - on PCSK9 - i therapy . - pubmed
CONCLUSION : In conclusion , PCSK9 - i therapy significantly ameliorate steatosis biomarkers in FH patients with low TG / HDL ; our results appear to be consistent with a beneficial role of PCSK9 - i on steatosis biomarkers in FH subjects with NAFLD . - pubmed
Basolateral Amygdala Serotonin 2C Receptor Regulates Emotional Disorder - Related Symptoms Induced by Chronic Methamphetamine Administration . - pubmed
Neuropharmacology and virus - mediated silencing strategies confirmed that targeting 5 - HT2CR reversed the depressive and anxious behaviors induced by chronic MA administration . - pubmed
Thus , herein , for the first time , we report that the abnormal regulation of 5 - HT2CR is involved in the manifestation of emotional disorder - like symptoms induced by chronic MA use . - pubmed
Our study suggests that 5 - HT2CR in the BLA is a promising clinical target for the treatment of MA - induced emotional disorders . - pubmed
Sulfenylation of Smad3 at cysteine-64 inhibits its DNA binding activity , while mutation of this site attenuates the protective effects of SO2 on angiotensin II - induced vascular remodeling and hypertension . - pubmed
Administration of 10(-9)-10(-7 ) mol / L ET caused dose - dependently severe contracture of myocytes , increase in cytosolic lactate dehydrogenase leakage and increase of cellular total calcium . - pubmed
Amplification of the N - myc gene in human neuroblastomas : tandemly repeated amplicons within homogeneously staining regions on different chromosomes with the retention of single copy gene at the resident site . - pubmed
[ The effect of elastase on aminonucleoside nephrosis -- on renal vascular system ] . - pubmed
In addition , elastase possibly inhibits this process and thereby protect glomeruli from sclerosis . - pubmed
The patients were grouped according to time course of abnormal serum alanine aminotransferase ( ALT ) levels into three categories ( chronic biochemical disease , biochemically resolved chronic disease , and acute disease ) . - pubmed
Viremia in two patients with normal ALT level suggests that hepatitis is not only caused by viral cytopathic effects , but also by immunologic reactions against virus - infected cells . - pubmed
Clinically , leukopenia with neutropenia and low plasma levels of copper and ceruloplasmin were seen in all cases . - pubmed
ACTH and cortisol production decreases , metabolism slows down and due to an adrenal insufficiency for which the pituitary is responsible there are characteristic changes in the cortisol - dependent metabolic processes . - pubmed
[ Clinical use of bromelain ( Ananase ) in chronic rhino - sinusitis ] . - pubmed
[ Thyroid acetylcholinesterase in thyrotoxicosis and goiter ] . - pubmed
The positive margin rate was not increased after reevaluation with cytokeratin , PSA and prostatic acid phosphatase immuno - staining but of 4 cases initially staged as P0 on hematoxylin and eosin evaluation 2 had microscopic foci of cancer with prostatic acid phosphatase staining . - pubmed
The initial rapid decrease in PSA results from cessation of androgen regulated PSA synthesis and apoptosis , while the ongoing slower decrease reflects decreasing tumor volume . - pubmed
IGFBP-3 is a poor parameter for assessment of clinical activity in acromegaly . - pubmed
OBJECTIVE : Elevated serum IGF - I and IGF binding protein-3 ( IGFBP-3 ) levels have been found in patients with active acromegaly . - pubmed
MEASUREMENTS : Twenty - four - hour sampling for serum GH in patients with acromegaly , serum IGF - I and IGFBP-3 . - pubmed
RESULTS : Mean IGF - I levels were 22.0 nmol / l ( range 6.5 - 38.4 ) in the healthy adults and 118.7 nmol / l ( range 67.7 - 206.0 ) in patients with acromegaly . - pubmed
Mean IGFBP-3 levels were 3.5 mg / l ( range 2.1 - 4.8 ) in controls and 5.4 mg / l ( range 4.2 - 6.6 ) in patients with acromegaly . - pubmed
Mean IGF - I / IGFBP-3 ratios were 6.5 nmol / mg ( range 1.9 - 14.5 ) in the healthy adults and 22.0 nmol / mg ( range 14.3 - 32.7 ) in patients with acromegaly . - pubmed
There was a considerable overlap for IGFBP-3 levels but not for IGF - I levels , between normals and acromegalics . - pubmed
The IGF - I / IGFBP-3 ratio also showed overlap between normals and acromegalics . - pubmed
There was a significant correlation between the mean 24 - hour GH and IGFBP-3 levels ( P = 0.036 ) and between the IGF - I and IGFBP-3 levels ( P & lt ; 0.002 ) in acromegaly . - pubmed
In patients with acromegaly , the IGFBP-3 levels showed a decrement , but the IGF - I / IGFBP-3 ratio did not change significantly with age . - pubmed
CONCLUSIONS : IGFBP-2 has no additional discriminatory value over IGF-1 measurements for the assessment of clinical activity in acromegaly . - pubmed
In acromegaly , IGFBP-3 decreases with increasing age . - pubmed
In acromegaly , IGFBP-3 levels significantly correlate with mean 24 - hour GH levels and IGF - I levels . - pubmed
The contribution of each methodology in clarifying the extent of involvement of DGR in esophageal mucosal injury is reviewed . - pubmed
An inherited dysfunctional fibrinogen variant , denoted as fibrinogen Milano III , was found in a 13 - year - old girl suffering from recurrent venous thrombosis . - pubmed
Radicicol , a protein tyrosine kinase inhibitor , suppresses the expression of mitogen - inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis . - pubmed
Radicicol also inhibited COX-2 expression in vivo in glomeruli of rats with experimental glomerulonephritis induced by the anti - glomerular basement membrane antibodies , in which COX-2 expression is known to be enhanced . - pubmed
Pulmonary expression of ICAM-1 and LFA-1 in experimental Goodpasture ' s syndrome . - pubmed
The functional importance of ICAM-1 and its ligands , the beta 2 - integrins , in leukocytic accumulation in pulmonary injury has been recently demonstrated in experimental models of lung disease . - pubmed
In the current study we have used immunogold ultrastructural techniques to define the precise location of ICAM-1 in the lung and its interaction with beta 2 - integrin expressing leukocytes in the early stages of experimental Goodpasture ' s ( GP ) syndrome in the rat . - pubmed
In GP syndrome there is an increase in ICAM-1 expression , which is still confined to the alveolar type I epithelial cells and capillary endothelium . - pubmed
Cytologic examination and carcinoembryonic antigen assay of fine needle aspirates of bone tumors . - pubmed
A prospective study of 28 consecutive fine needle aspirates of bone was conducted comparing the sensitivities of cytologic diagnosis with carcinoembryonic antigen ( CEA ) content to determine if the CEA assay could enhance the sensitivity of cytologic diagnosis of carcinoma metastatic to bone . - pubmed
Mean CEA and sensitivity were highest for adenocarcinoma of lung ( 361.5 ng / mL , 77 % ) , lowest for carcinoma of breast and negative for lymphoma , myeloma and benign aspirates . - pubmed
High CEA was useful in ( 1 ) suggesting adenocarcinoma of lung in patients with an unknown primary , ( 2 ) suggesting a new primary lung adenocarcinoma in a patient with previous transitional cell carcinoma of bladder , and ( 3 ) discriminating lung adenocarcinoma from adenocarcinomas of kidney , thyroid , prostate or endometrium . - pubmed
An immunohistochemical study of opsin in photoreceptor cells following light - induced retinal degeneration in the rat . - pubmed
Light - induced retinal degeneration has been hypothesized to be rhodopsin - mediated . - pubmed
We used light and electron immunohistochemistry to study the alterations in retinal opsin immunoreactivity in a rat model of retinal photic injury . - pubmed
It appears that , despite severe light - mediated retinal degeneration , anti - opsin immunoreactivity persisted in the photoreceptor cells but with an altered pattern in damaged rod outer segments and photoreceptor perikarya . - pubmed
Anemia and neutropenia are generally caused by inadequate production because of suppression of the bone marrow by the HIV infection through abnormal cytokine expression and alteration of the bone marrow microenvironment . - pubmed
Supportive care for anemia includes the use of erythropoietin in addition to the judicious use of red blood cell transfusions . - pubmed
Therapy for neutropenia includes the use of the myeloid growth factors G - CSF and GM - CSF . - pubmed
Products from mast cells influence T lymphocyte proliferation and cytokine production -- relevant to allergic asthma ? - pubmed
It is hypothesized that this might be a negative feed back mechanism operating in allergic subjects , by which the Th2 - driven IgE production and eosinophilia are counteracted . - pubmed
Insulin sensitivity was evaluated using an insulin suppression test in 40 newly diagnosed patients with coronary artery disease and no previous history of metabolic disorders , who were not taking any medication which might affect insulin sensitivity . - pubmed
The insulin suppression test consisted of a constant infusion of glucose , insulin and somatostatin for 150 min ; insulin resistance was estimated by determining the steady - state plasma glucose concentrations during the last 60 minutes of the test . - pubmed
We conclude that captopril and , to a lesser extent , diltiazem improve insulin sensitivity in patients with stable coronary artery disease . - pubmed
The role of protein kinase C activation in the pathogenesis of diabetic vascular complications . - pubmed
Many vascular diseases in diabetes are known to be associated with the activation of the diacylglycerol ( DAG )- protein kinase C ( PKC ) pathway . - pubmed
Among the various PKC isoforms , the beta - isoform has been shown to be persistently activated in diabetic animals . - pubmed
Multiple lines of evidence have shown that many vascular alterations in diabetes -- such as a decrease in the activity of Na +- K +- adenosine triphosphatase ( Na +- K +- ATPase ) , and increases in extracellular matrix , cytokines , permeability , contractility , and cell proliferation -- are caused by activation of PKC . - pubmed
Inhibition of PKC by two different kinds of PKC inhibitors , LY333531 , a selective PKC - beta - isoform inhibitor , and d - alpha - tocopherol , were able to prevent or reverse the various vascular dysfunctions in diabetic rats . - pubmed
These results have also provided in vivo evidence that DAG - PKC activation could be responsible for the hyperglycemia - induced vascular dysfunctions in diabetes . - pubmed
Clinical studies are now being performed to clarify the pathogenic roles of the DAG - PKC pathway in developing vascular complications in diabetic patients . - pubmed
The impact of the vascular pathology on the evolution of tissue fibrosis is not known ; still , cytokines ( TGFbeta , IL4 ) , vascular factors ( endothelin ) , and growth factors ( PDGF ) are possibly crucial signals that link the vascular disease to tissue fibrosis . - pubmed
Directional transneuronal infection by pseudorabies virus is dependent on an acidic internalization motif in the Us9 cytoplasmic tail . - pubmed
A syndrome of acquired glucocorticoid resistance has been described in patients with HIV with hypercortisolism and a lower affinity of the glucocorticoid receptors . - pubmed
CD55 is over - expressed in the tumour environment . - pubmed
791Tgp72 is an antigen which has been used successfully as a target for both tumour imaging and cancer vaccines . - pubmed
Quantitative expression of CD55 in the tumour environment was therefore studied . - pubmed
Tumour cells showed a 4 - 100 - fold increase in CD55 cell surface expression when compared to normal cells . - pubmed
Immunohistochemical staining of colorectal tumours also revealed high expression of CD55 in the stroma . - pubmed
Tumour cell lines deposit CD55 into their extracellular matrix ( ECM ) in direct proportion to their cell surface expression . - pubmed
Although it remains unclear why CD55 is upregulated in the tumour environment its high level of expression on tumour cells and associated endothelium may explain why it is a good target for both imaging and immunotherapy . - pubmed
Expression and clinical significance of the G1 - S modulators in intrahepatic cholangiocellular carcinoma . - pubmed
OBJECTIVE : To elucidate the clinical roles of G1 - S modulators in cholangiocellular carcinoma ( CCC ) . - pubmed
METHODS : We performed immunohistochemistry using antibodies against the retinoblastoma gene product ( pRb ) , p16 , p21 , p27 , p53 and cyclin D1 for 41 cases of CCC as well as normal bile ducts . - pubmed
RESULTS : The p27 labeling index ( LI ) was significantly higher in cases without lymph node metastasis than in normal bile ducts , but it decreased greatly in cases with lymph node metastasis . - pubmed
CONCLUSIONS : These results suggest that in CCC : ( 1 ) p27 expression reflects the biological character of the carcinoma and may regulate its progression ; ( 2 ) cyclin D1 plays a crucial role in cell cycle progression , and ( 3 ) aberrant p53 expression has some effect on CCC cell proliferating activity . - pubmed
Concomitant use of clarithromycin or other potent inhibitors of CYP3A4 with repaglinide may enhance its blood glucose - lowering effect and increase the risk of hypoglycemia . - pubmed
We , therefore , compared the infarct : risk volume ratio ( I : R% ) after 30 - min global ischemia in Langendorff - perfused hearts from outbred C57BL/6 mice with that in wild - type mice derived from heterozygote x heterozygote crosses of two different in - house C57BL/6 mouse lines with targeted disruption of an MKK3 or MAPKAPK2 allele . - pubmed
Gastric intramucosal pH ( pHi ) , plasma endotoxin in portal vein , and plasma D - lactic acid were measured and blood samples were cultured at different time intervals after trauma . - pubmed
[ Insulin - requiring hypernephroma in a diabetic ] . - pubmed
Cloning of the TSH receptor has led to marked progress in the understanding of the pathogenesis of hyperthyroidism . - pubmed
Genetic studies in familial cases of Graves disease have allowed to dismiss the TSH receptor as a candidate gene . - pubmed
In cases of non immune hyperthyroidism the implication of activating mutations of the TSH receptor and of the a subunit of Gs has been described . - pubmed
Lessons from models of SOD1 - linked familial ALS . - pubmed
Ten years ago , the linkage between mutations in the gene coding for the antioxidant enzyme Cu , Zn superoxide dismutase ( SOD1 ) and the neurodegenerative disease known as familial amyotrophic lateral sclerosis ( FALS ) was established . - pubmed
The cellular functions that are impaired in motoneurons as a consequence of molecular alterations induced by the expression of FALS SOD1 converge on pathways that might be activated in sporadic ALS by other toxic factors . - pubmed
Increased glutathione ( gamma - glutamylcysteinylglycine ; GSH ) conjugation ( inactivation ) of alkylating anticancer drugs due to overexpression of cytosolic glutathione S - transferase ( GST ) is believed to be an important mechanism in tumor cell resistance to alkylating agents . - pubmed
However , the potential involvement of microsomal GST in the establishment of acquired drug resistance ( ADR ) to CHB remains uncertain . - pubmed
Loss of the tight junction protein claudin 4 correlates with histological growth - pattern and differentiation in advanced gastric adenocarcinoma . - pubmed
It has been suggested that the loss of tight junction function is related to tumor differentiation , but little is known about the roles of major proteins , such as claudin 4 and ZO-1 , in gastric cancer . - pubmed
The aims of this study were to examine the differences in expression of E - cadherin , claudin 4 , and ZO-1 proteins according to the pathological and clinical features of advanced gastric cancer . - pubmed
The expression of E - cadherin , claudin 4 , and ZO-1 was analyzed immuno - histochemically using formalin - fixed , paraffin - embedded tissues obtained from 49 patients who underwent radical resection for advanced gastric cancer . - pubmed
Immunostaining for E - cadherin , claudin 4 , and ZO-1 was reduced in 69 , 69 , and 37 % of cancers , respectively . - pubmed
According to the Lauren classification , the reduced expression of E - cadherin and claudin 4 was more frequent in diffuse than intestinal type tumors ( p<0.001 ) . - pubmed
Western blot analysis and RT - PCR also showed decreased claudin 4 expression in diffuse type tumors and poorly - differentiated adenocarcinoma . - pubmed
The reduced expression of claudin 4 and E - cadherin correlates with disruption of glandular structure and loss of differentiation , which suggests that the dysfunction of claudin 4 may play a role in the disruption of cell - to - cell adhesion in diffuse type gastric cancer and in a loss of differentiation . - pubmed
Administration of leptin during pregnancy and lactation to these protein - restricted dams produces offspring that have increased metabolic rate and do not become obese or insulin resistant when fed on a high - fat diet . - pubmed
Leptin administration to protein - restricted dams inhibits the suppression of 11beta - HSD-2 and may be one mechanism by which the metabolic syndrome is prevented . - pubmed
We now show that expression of constitutively active beta - catenin in normal lymphoid or myeloid progenitors generated uncommitted cells with multilineage differentiation potential . - pubmed
Evidence of an association between desmoglein 3 haplotypes and pemphigus vulgaris . - pubmed
BACKGROUND : Pemphigus vulgaris ( PV , OMIM 169610 ) is a severe blistering disorder of the skin and mucous membranes , caused by the production of autoantibodies directed against the epithelial adhesive protein desmoglein 3 . - pubmed
Although an association between PV and HLA class II alleles has been established , the genetic factors predisposing to the disease remain poorly understood , the rarity of PV hampering the recruitment of substantial patient cohorts . - pubmed
OBJECTIVES : To investigate DSG3 as a candidate PV susceptibility gene . - pubmed
A related haplotype ( DSG3*TCCCC ) was associated with PV in the Indian dataset ( P = 0.002 ) . - pubmed
CONCLUSIONS : These results suggest that genetic variation of DSG3 may be an additive risk factor predisposing to PV and warrant further investigations of this gene . - pubmed
Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas . - pubmed
Certain claudins have been shown to have relevance in tumor development , with some of them , especially claudin-4 , even suggested as future therapeutic target . - pubmed
The aim of the present study was to analyze the expression of claudin-4 in the biliary tree , biliary tract cancers and hepatocellular carcinomas . - pubmed
Intense membranous immunolabeling was found for claudin-4 in all biliary tract cancers unrelated to the primary site of origin , namely intrahepatic , extrahepatic or gallbladder cancers . - pubmed
Normal biliary epithelium showed weak positivity for claudin-4 . - pubmed
In contrast , normal hepatocytes and tumor cells of hepatocellular carcinomas did not express claudin-4 . - pubmed
Cytokeratins , as CK7 ( 92 % ) and CK19 ( 83 % ) were mostly positive in biliary tract cancers , however , one - third of hepatocellular carcinomas also expressed CK7 ( 34 % ) . - pubmed
HSA antibody ( HepPar1 ) reacted with the majority of hepatocellular carcinomas ( 86 % ) , while being positive in a low percentage of the biliary tract cancers ( 8 % ) . - pubmed
In conclusion , this is the first report of a significantly increased claudin-4 expression in biliary tract cancers , which represents a novel feature of tumors of biliary tract origin . - pubmed
Claudin-4 expression seems to be a useful marker in differentiating biliary tract cancers from hepatocellular carcinomas and could well become a potential diagnostic tool . - pubmed
CONCLUSION : The effects of Tongjiang granule on treating GERD can be achieved by decreasing the hydrochloric acid in gastric juice , increasing the motilin in blood and promoting the gastric impetus in the animal experiment . - pubmed
PSA relapse ( median PSA relapse - free survival , 10.3 years for radiotherapy vs 3.1 years for observation ; HR , 0.43 ; 95 % CI , 0.31 - 0.58 ; P<.001 ) and disease recurrence ( median recurrence - free survival , 13.8 years for radiotherapy vs 9.9 years for observation ; HR , 0.62 ; 95 % CI , 0.46 - 0.82 ; P = .001 ) were both significantly reduced with radiotherapy . - pubmed
CONCLUSIONS : In men who had undergone radical prostatectomy for pathologically advanced prostate cancer , adjuvant radiotherapy resulted in significantly reduced risk of PSA relapse and disease recurrence , although the improvements in metastasis - free survival and overall survival were not statistically significant . - pubmed
Polymorphisms in methionine synthase reductase and betaine - homocysteine S - methyltransferase genes : risk of placental abruption . - pubmed
We assessed whether polymorphisms in MTRR ( 66A-->G ; I22 M ) and BHMT ( 742G-->A ; R239Q ) were associated with abruption . - pubmed
CONCLUSIONS : In this population , there was an association between the homozygous mutant form of BHMT ( 742G-->A ) polymorphism and increased risk for placental abruption . - pubmed
BACKGROUND : Intravenous immunoglobulin ( IVIG ) is increasingly being used to treat inflammatory and autoimmune disease . - pubmed
Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy . - pubmed
The mice developed albuminuria , renal insufficiency , and parenchymal inflammation / fibrosis accompanied by overexpression of intrarenal converting enzyme and angiotensin II . - pubmed
Angiotensin - converting enzyme inhibition confers renoprotection in adriamycin nephropathy by reducing intrarenal angiotensin II and augmenting Ac - SDKP expression that together attenuate MAPK signaling and its downstream proinflammatory and fibrogenic properties . - pubmed
PURPOSE : Romidepsin ( FK228 , depsipeptide , FR901228 ) , a unique cyclic depsipeptide with a histone deacetylase inhibitor ( HDACI ) activity , is a potential cancer therapeutic agent and currently under clinical trials for several types of cancer . - pubmed
Our data indicate that DMCA can potentiate the HDACI activity of romidepsin and other biological activities , such as cell cycle arrest and apoptosis ; these effects were accompanied with the expression of various key cell cycle regulators in different bladder cancer cells . - pubmed
CONCLUSIONS : a ) in the Italian population sexual dimorphism affects pre - natal thyroid migration but neither biochemical severity of ectopia , nor pre - natal bone maturation and psychomotor development ; b ) girls with CH do not require higher doses of initial therapy in order to achieve TSH normalization ; c ) future developmental and molecular studies on ectopia etiology in CH need to take into account the effect of sexual dimorphism . - pubmed
Changes in subcellular localisation of MI - ER1 alpha , a novel oestrogen receptor - alpha interacting protein , is associated with breast cancer progression . - pubmed
The oestrogen receptor - alpha ( ER alpha ) plays a key role in breast development and tumorigenesis and inhibiting its activity remains a prime strategy in the treatment of ER alpha - positive breast cancers . - pubmed
Thus , elucidation of the molecular mechanisms responsible for regulating ER alpha activity may facilitate the design of new , more effective breast cancer therapies . - pubmed
We investigated the ability of MI - ER1 alpha to bind to ER alpha in HEK293 and MCF-7 breast carcinoma cells , using co - immunoprecipitation assays . - pubmed
Functional analysis revealed that overexpression of MI - ER1 alpha in T47D breast carcinoma cells results in inhibition of oestrogen - stimulated anchorage - independent growth , suggesting that MI - ER1 alpha may play a role in regulating breast carcinoma cell proliferation in vivo . - pubmed
No consistent difference in the MI - ER1 alpha expression level between normal breast tissue and breast carcinoma was discernible . - pubmed
However , there was a dramatic shift in the subcellular localisation : nuclear MI - ER1 alpha was detectable in 75 % of normal breast samples and in 77 % of hyperplasia , but in breast carcinoma , only 51 % of DCIS , 25 % of ILC and 4 % of IDC contained nuclear staining . - pubmed
This shift from nuclear to cytoplasmic localisation of MI - ER1 alpha during breast cancer progression suggests that loss of nuclear MI - ER1 alpha might contribute to the development of invasive breast carcinoma . - pubmed
CONCLUSIONS : Transient atrophy and regeneration were observed only in the GL , and the changes in the MyHCIIb plus MyHCeom appeared to be related to these changes . - pubmed
17 - AAG sensitized malignant glioma cells to death - receptor mediated apoptosis . - pubmed
17 - AAG is a selective HSP90 - inhibitor that exhibited therapeutic activity in cancer . - pubmed
In this study three glioblastoma cell lines ( U87 , LN229 and U251 ) were treated with 17 - AAG , tumor necrosis factor - related apoptosis - inducing ligand ( TRAIL ) or the combination of both . - pubmed
Treatment with subtoxic doses of 17 - AAG in combination with tumor necrosis factor - related apoptosis - inducing ligand ( TRAIL ) induces rapid apoptosis in TRAIL - resistant glioma cells , suggesting that this combined treatment may offer an attractive strategy for treating gliomas . - pubmed
In addition , over - expression of survivin attenuated cytotoxicity induced by the combination of 17 - AAG and TRAIL . - pubmed
In summary , survivin is a key regulator of TRAIL-17 - AAG mediated cell death in malignant glioma . - pubmed
BACKGROUND / AIM : Viral eradication in chronic hepatitis C patients with sustained virological response ( SVR ) after interferon ( IFN ) therapy remains controversial . - pubmed
CONCLUSION : This long - term study evaluating 157 patients demonstrated that SVR assessed by TMA is durable , and HCV antibodies were markedly decreased ( mainly those directed against the non - structural proteins ) , emphasizing an absence of ongoing infection . - pubmed
These results support the concept that there is a race between the ability of a cell to detect and respond to virus infection and the ability of a virus to block the IFN response . - pubmed
The diagnosis of MNGIE disease can be established in a proband by detection of one of the following : ( 1 ) biallelic pathogenic variants in TYMP ( formerly known as ECGF1 ) ; ( 2 ) markedly reduced levels of thymidine phosphorylase enzyme activity ; or ( 3 ) elevated plasma concentrations of thymidine and deoxyuridine . - pubmed
GENETIC COUNSELING : MNGIE disease is inherited in an autosomal recessive manner . - pubmed
Unless an individual with MNGIE disease has offspring with either an affected individual or a carrier , his / her offspring will be obligate heterozygotes for a pathogenic variant in TYMP . - pubmed
After surgery , glycemic control is restored by a combination of enforced caloric restriction , enhanced insulin sensitivity , and increased insulin secretion . - pubmed
Finally , as the long - lived Fas protein remained stable during the early period of infection , experiments with the HSV-1 UL39 deletion mutant ICP6 showed that HSV-1 R1 could be essential for the protection of HSV-1 - infected cells against FasL. - pubmed
In a study of sixty institutionalist Schizophrenic patients , sixty chronic schizophrenic outpatients and an equal number of age and sex matched normal controls from the same regional background , the prevalence of HBsAG was six , one and zero respectively . - pubmed
Two patients ( 29 % ) harbored a known mutation in the RASA1 gene , associated with a hereditary vascular syndrome : capillary malformation - arteriovenous malformation . - pubmed
A 30 - kDa surface collagen binding protein peroxiredoxin of Entamoeba histolytica ( EhCBP30 ) was evaluated either alone or fused to the chaperone ( CHP ) or ATPase ( ATP ) domains of heat shock protein 70 of Trypanosoma cruzi ( TcHSP70 ) as a vaccine candidate in a hamster model of experimental amoebic liver abscess ( ALA ) development . - pubmed
Partial agonist of benzodiazepine receptors Ro 19 - 8022 elicits withdrawal symptoms after short - term administration in immature rats . - pubmed
CONCLUSIONS : Findings lend support to a modulatory effect of common OXTR variants on Harm Avoidance in healthy caucasian women and invite resequencing of the gene in anxiety phenotypes to identify more explanatory functional variation . - pubmed
Long - term efficacy of insulin pump therapy in children with type 1 diabetes mellitus . - pubmed
We evaluated the long - term efficacy of continuous insulin infusion pump therapy ( CSII ) in pediatric patients with type 1 diabetes mellitus ( T1DM ) . - pubmed
METHODS : This was a retrospective observational study which included 131 patients with T1DM who transitioned to an insulin pump from multiple daily insulin ( MDI ) injections between 1999 and 2009 and were followed by one endocrinologist . - pubmed
Previously , we found that afimbrial adhesin gene ( afa)-positive motile DAEC strains isolated from patients with diarrhoea induce high levels of IL-8 secretion in Caco-2 cells via toll - like receptor 5 ( TLR-5 ) , while non - motile strains did not . - pubmed
The aim of this study was to compare virulence properties , including the phylogenetic groups , afa subtypes , IL-8 secretion levels , and the effects on tight junctions , of DAEC strains isolated from healthy persons with those isolated from patients with diarrhoea . - pubmed
These data indicate that in conditions relevant to epidermal wound healing , LPA induces SOCE and NFAT activation through Orai1 channels and promotes cell migration through a calcineurin / NFAT2 - dependent pathway . - pubmed
METHODS : The CIA model was induced by intradermal injection of bovine collagen type II emulsion from the tail of 40 healthy male Wistar rats . - pubmed
RESULTS : Compared with the model group , after the intervention of WJR , 222 differentially expressed genes were identified in CIA rats , including 76 genes up - regulated ( such as RatNP-3b and so on ) and 146 downregulated ( such as Angptl 2 , Muc1 , bcl-2 , and so on ) . - pubmed
The study of such cases emphasizes the complexity of genetic interactions that underlie the phenotype of beta - thal and highlight the importance of the regulation of Hb F production in beta - thal syndromes . - pubmed
BACKGROUND : The Interleukin 28B ( IL28B ) rs12979860 polymorphisms was recently reported to be associated with the human T - cell leukemia virus type 1 ( HTLV-1 ) proviral load ( PvL ) and the development of the HTLV-1 - associated myelopathy / tropical spastic paraparesis ( HAM / TSP ) . - pubmed
CONCLUSIONS : Our study failed to support the previously reported positive association between the IL28B rs12979860 polymorphisms and an increased risk of developing HAM / TSP in the Brazilian population . - pubmed
We conclude that hormone ( tamoxifen ) therapy is a useful treatment for elderly postmenopausal woman with estrogen receptor - positive advanced breast cancer . - pubmed
We evaluate the effects of long - term telmisartan therapy on renal dysfunction , podocyte injury , inflammation , and transforming growth factor - beta1 ( TGF - beta1)/Smad , epithelial - mesenchymal transition ( EMT ) , mitogen - activated protein kinase ( MAPK ) , Rho - kinase , and cell - cycle progression pathway in the renal cortex of SHRSP fatty rats . - pubmed
CONCLUSION : Long - term telmisartan therapy may improve renal dysfunction , glomerulosclerosis , podocyte injury , and inflammation associated with EMT , TGF - beta / Smad , MAPK , Rho - kinase pathway in SHRSP fatty rats . - pubmed
Gene amplification and overexpression of Aurora - C in breast and prostate cancer cell lines . - pubmed
Human aurora kinases are three highly conserved serine / threonine kinases with regulatory function in chromosome alignment , chromosome segregation , and cytokinesis during cell cycle progression and their overexpression associates with malignant transformation and proliferation of cancer cells . - pubmed
We evaluated the expression of three Aurora kinases by real - time RT - PCR in well - known breast and prostate cancer cell lines . - pubmed
At DNA level , only Aurora - C showed gene amplification in breast cancer cell lines ( p & lt ; 0.005 ) . - pubmed
However , simultaneous supplementation with quercetin ( 75 mg / kg ) attenuated the toxicity induced by PNP through renewal of the antioxidant enzyme 's status , alleviating apoptosis by regulating the expressions of Bax and Bcl - xl , XBP-1 and HO-1mRNAs , and the regulation of caspase-3 activity . - pubmed
Towards achieving this goal , several researchers have carried out studies in various cell lines and in vivo and have deciphered that fucoxanthin exerts its anti - proliferative and cancer preventing influence via different molecules and pathways including the Bcl-2 proteins , MAPK , NFkappaB , Caspases , GADD45 , and several other molecules that are involved in either cell cycle arrest , apoptosis , or metastasis . - pubmed
Hemorheological parameters , such as WBV and fibrinogen , and AChE - RBC were ultimately proven to be useful biomarkers of the severity and progression of AD patients . - pubmed
Early - onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice . - pubmed
Alzheimer ' s disease ( AD ) and frontotemporal lobar degeneration ( FTLD ) are neurodegenerative " tauopathies " characterized by hyperphosphorylated tau accumulation and neurofibrillary tangles . - pubmed
The P301S mutation of tau , a causal mutation of a familial type of FTLD , is believed to be involved in neurodegenerative progression . - pubmed
TPR50 mice demonstrated cognitive dysfunction at 5 months . - pubmed
Therefore , cognitive dysfunction in TPR50 mice may result from early MT dysfunction and impaired axonal transport rather than accumulation of insoluble tau and neurodegeneration . - pubmed
TPR50 mice are a valuable new model to study progression of tauopathies at both the behavioral and neurocellular levels and may also prove useful for testing new therapies for neurodegenerative diseases . - pubmed
Differential expression of ETS family transcription factors in NCCIT human embryonic carcinoma cells upon retinoic acid - induced differentiation . - pubmed
To identify critical ETS factor(s ) in germ cell - derived cancer cells , we examined the expression patterns of the 27 ETS transcription factors in naive and differentiated NCCIT human embryonic carcinoma cells , which exhibit both pluripotent and tumorigenic characteristics . - pubmed
These data suggest that PEA3 and ESE-1 may play important roles in pluripotent and tumorigenic embryonic carcinoma cells . - pubmed
A novel homozygous mutation in ALS2 gene in four siblings with infantile - onset ascending hereditary spastic paralysis . - pubmed
Autosomal recessive early onset forms of motor neuron disorders including infantile - onset ascending hereditary spastic paraplegia ( OMIM # 607225 ) are due to homozygous mutations in the ALS2 gene . - pubmed
Here , we report on a novel splice - site mutation of the ALS2 ( c.2351 + 2C > A ) in four children of a consanguineous union with infantile - onset ascending hereditary spastic paraplegia . - pubmed
When challenged with food deprivation , vehicle and RAP - treated rats responded with rebound hyperphagia , suggesting that RAP was not inhibiting compensatory responses to weight loss . - pubmed
The TRPV1 functional channel is the most investigated TRP channel in these tissues , owing to its contribution to maintaining tissue homeostasis as well as eliciting wound healing responses to injury . - pubmed
Integrative investigation on breast cancer in ER , PR and HER2 - defined subgroups using mRNA and miRNA expression profiling . - pubmed
Here we have explored the intrinsic differences among breast cancer subgroups defined by immunohistochemical expression ( IHC ) of hormone receptors ER and PR as well as human epidermal growth factor receptor 2 ( HER2 ) using the mRNA and miRNA expression profiles of 115 tumors . - pubmed
This study contributes to elucidating the intrinsic relations among breast cancer subgroups defined by ER , PR and HER2 expression via integrating mRNA and miRNA expression . - pubmed
Characterization of JNJ-42847922 , a Selective Orexin-2 Receptor Antagonist , as a Clinical Candidate for the Treatment of Insomnia . - pubmed
Analysis of variance ( ANOVA ) and Tukey 's test were used to verify any differences in creatinine levels and estimated clearance at 0 , 6 , 12 , 24 and 36 months , adjusting for the co - variables sex , skin color , age & gt;50 years , arterial hypertension , diabetes and the use of the ritonavir - boosted protease inhibitors ( PI / r ) lopinavir / r or atazanavir / r. The software package STATISTICA 10 ( ) was used for statistical analysis . - pubmed
Nurse - led titration of angiotensin converting enzyme inhibitors , beta - adrenergic blocking agents , and angiotensin receptor blockers for people with heart failure with reduced ejection fraction . - pubmed
Beta - adrenergic blocking agents , angiotensin converting enzyme inhibitors ( ACEIs ) , and angiotensin receptor blockers ( ARBs ) can improve survival and reduce hospital readmissions and are recommended as first - line therapy in the treatment of heart failure . - pubmed
Expression of scavenger receptor A in rat 's liver tissue during acute obstructive cholangitis and its significance . - pubmed
Our aim was to investigate the expression of scavenger receptor A ( SRA ) in rat 's liver tissue during AOC and its relation with the inflammatory mediators and hepatic injury caused by endotoxins . - pubmed
CONCLUSION : In AOC , the expression of SRA in liver gradually decreased with progressive increase in level of plasma endotoxins and hepatic injury suggesting its importance in the defense mechanism . - pubmed
Interleukin-6 , MCP-1 , IP-10 , and MIG are sequentially expressed in cerebrospinal fluid after subarachnoid hemorrhage . - pubmed
BACKGROUND : Interleukin-6 ( IL-6 ) , an inflammatory cytokine , plays important roles in cerebrospinal fluid ( CSF ) after subarachnoid hemorrhage ( SAH ) . - pubmed
Chemokines are chemoattractant cytokines that regulate trafficking of monocytes / macrophages and lymphocytes to sites of inflammation . - pubmed
However , no studies have been reported regarding the temporal expression of these cytokines in CSF after SAH . - pubmed
FINDINGS : The concentrations of IL-6 , monocyte chemoattractant protein-1 ( MCP-1 ) , interferon - gamma - inducible protein-10 ( IP-10 ) , and monokine induced by interferon - gamma ( MIG ) in the CSF of ten patients with SAH were measured using ELISA kits over a period of 14 days . - pubmed
CONCLUSIONS : The present investigation demonstrated that increases in IL-6 levels may induce the expression of MCP-1 in CSF after SAH , followed by increases in the expression of IP-10 and MIG . - pubmed
Dynamic changes in the levels of these cytokines may induce inflammation and may be closely associated with the development of delayed ischemic neurological deficits after SAH . - pubmed
ERAP1 also plays a role in angiogenesis , cell cycle progression and migration , events that are shared between tumour cells and placenta formation . - pubmed
Here we discuss the similarities between tumour and extravillous trophoblast cells in their immune modulatory , invasion , migration and proliferation properties in the context of ERAP1 and its role in establishment of solid tumours and placenta formation . - pubmed
GTSP1 expression in non - smoker and non - drinker patients with squamous cell carcinoma of the head and neck . - pubmed
We studied the expression of GTSP1 in tumor and non - tumor tissue samples from patients with and without these risks to identify whether GTSP1 expression differs according to exposure to carcinogens . - pubmed
RESULTS : GTSP1 expression was detected in the tumors of both groups . - pubmed
GTSP1 expression was higher in the non - tumor margins of SD patients ( p = 0.004 ) . - pubmed
No differences in survival were observed according to GTSP1 staining in tumors and non - tumor margins . - pubmed
CONCLUSION : This study showed that GTSP1 was expressed in tumors of HNSCC patients regardless of smoking , drinking or HPV infection status . - pubmed
The difference in GTSP1 expression in non - tumor margins between the two groups may have been due to two possible reasons . - pubmed
First , elevated GTSP1 expression in SD patients might be the result of activation of GTSP1 in response to exposure to carcinogens . - pubmed
TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup . - pubmed
Experimental Design : We have interrogated a total of seven primary prostate cancer cohorts ( n = 1,900 ) , two metastatic castration - resistant prostate cancer datasets ( n = 293 ) , and one prospective cohort ( n = 1,385 ) to assess the impact of TOP2A and EZH2 expression on prostate cancer cellular program and patient outcomes . - pubmed
We also performed IHC staining for TOP2A and EZH2 in a cohort of primary prostate cancer patients ( n = 89 ) with known outcome . - pubmed
Finally , we explored the therapeutic potential of a combination therapy targeting both TOP2A and EZH2 using novel prostate cancer - derived murine cell lines . - pubmed
Results : We demonstrate by genome - wide analysis of independent primary and metastatic prostate cancer datasets that concurrent TOP2A and EZH2 mRNA and protein upregulation selected for a subgroup of primary and metastatic patients with more aggressive disease and notable overlap of genes involved in mitotic regulation . - pubmed
Importantly , TOP2A and EZH2 in prostate cancer cells act as key driving oncogenes , a fact highlighted by sensitivity to combination - targeted therapy . - pubmed
Mutations in the TFIIH subunits XPB , XPD , and p8 lead to severe premature ageing and cancer propensity in the genetic diseases xeroderma pigmentosum , Cockayne syndrome , and trichothiodystrophy , highlighting the importance of TFIIH for cellular physiology . - pubmed
This review discusses the main vascular structural and functional abnormalities during physiological and premature aging , as well as the mechanisms involved in the exacerbated CVD and accelerated aging induced by the accumulation of progerin and prelamin A. - pubmed
Prostate Specific Antigen Density as a Predictor of Clinically Significant Prostate Cancer When the Prostate Specific Antigen is in the Diagnostic Gray Zone : Defining the Optimum Cutoff Point Stratified by Race and Body Mass Index . - pubmed
PURPOSE : We assessed the predictive value of prostate specific antigen density to detect clinically significant prostate cancer , defined as prostate cancer grade group 2 or greater , in a series of men undergoing prostate biopsy with prostate specific antigen 4 to 10 ng / ml . - pubmed
We compared the AUC between prostate specific antigen and prostate specific antigen density to predict clinically significant and any prostate cancer vs no cancer . - pubmed
Prostate specific antigen density improved the performance of prostate specific antigen to detect significant cancer ( AUC 0.58 to 0.68 ) and any cancer ( AUC 0.55 to 0.69 , each p & lt;0.001 ) . - pubmed
This study was performed to investigate the efficacy of HCQ therapy by serial assessment of disease activity and serum levels of proinflammatory cytokines in SLE patients . - pubmed
RESULTS : Median levels of IL-1beta ( p & lt ; 0.001 ) , IL-6 ( p = 0.001 ) , and TNF - alpha ( p & lt ; 0.001 ) were significantly higher , whereas , median CH50 level was significantly lower ( p & lt ; 0.001 ) in SLE patients compared with controls . - pubmed
CONCLUSION : HCQ therapy is effective on clinical improvement of SLE patients through interfering with inflammatory signaling pathways , reducing anti - DNA autoantibodies and normalizing the complement activity . - pubmed
Correlation between RB1germline mutations and second primary malignancies in hereditary retinoblastoma patients treated with external beam radiotherapy . - pubmed
Retinoblastoma ( Rb ) results from biallelic inactivation of the RB1 gene . - pubmed
Hereditary Rb patients i. e germline carriers of a RB1 mutation also have a risk of developing subsequent malignant neoplasms ( SMN ) such as osteosarcomas . - pubmed
To decipher the relationship between RB1 genotype and SMN development in EBRT treated patients , we conducted a retrospective study in a cohort of 160 irradiated hereditary Rbs with fully resolved RB1 mutational status . - pubmed
We did n't find any difference in RB1 mutation type between patients with or without SMN , neither could we detect any linkage between mutation type and SMN location , SMN type and age at diagnosis . - pubmed
Interestingly , among 13 carriers of a RB1 low penetrance mutation , 3 of them developed sarcomas , a rare tumor that can not be attributed to the general population . - pubmed
Our study can not explain why a RB1 mutation leads or not to a SMN but demonstrated that EBRT patients with a low penetrance mutation remain at risk of SMN and should be cautiously monitored . - pubmed
half - marathon race ) to cause a defined quantity of lower body muscle injury and a systemic inflammatory response lasting up to 24 h. Using a high - sensitivity , multiplex assay ( Milliplex ; Millipore - Sigma ) we were able to identify 9 of 21 cytokines that were significantly elevated at either 4 or 24 h post half - marathon performance . - pubmed
Age , gender , the duration of admission , seasonal and monthly distribution of cases , diabetes and smoking status , white blood cell count , and C - reactive protein ( CRP ) levels were recorded . - pubmed
Diabetes status was not found to be associated with length of hospitalization and CRP levels . - pubmed
IPEC - J2 cells were pretreated with puerarin ( 200 mug / mL ) , baicalin ( 1 mug / mL ) , and berberine hydrochloride ( 100 mug / mL ) at 37 C for 3 h and then coincubated with the F4ac ETEC bacterial strain 200 at 37 C for 3 h. ETEC infection damaged the structure of IPEC - J2 cells , upregulated mucin 4 ( P & lt ; 0.01 ) and mucin 13 mRNA ( P & lt ; 0.05 ) expression , increased the apoptosis rate ( P & lt ; 0.05 ) , and promoted inflammatory responses ( IL-6 and CXCL-2 mRNA expression ) in IPEC - J2 cells by activating the nuclear factor - kappaB ( NF - kappaB ) signaling pathway . - pubmed
Cadherins are homophilic cell - cell adhesion molecules whose aberrant expression has often been shown to correlate with different stages of tumor progression . - pubmed
Both ligands have been previously developed as mimics of the tetrapeptide sequence Asp1 - Trp2 - Val3 - Ile4 of the cadherin adhesion arm , and have been shown to inhibit E - cadherin - mediated adhesion in epithelial ovarian cancer cells with millimolar potency . - pubmed
miR-454 - 3p exerts tumor - suppressive functions by down - regulation of NFATc2 in glioblastoma . - pubmed
We found that NFATc2 expression was significantly increased in both GBM tissues and cultured cell lines . - pubmed
Besides , expression levels of miR-454 - 3p were negatively associated with NFATc2 expression in GBM tissues . - pubmed
NFATc2 knockdown in GBM cells obviously inhibited cell proliferation and elevated apoptosis . - pubmed
Suppression of NFATc2 blocked the effects of miR-454 - 3p inhibitor on cell proliferation and apoptosis in GBM cells . - pubmed
The results indicated that miR-454 - 3p executed the tumor suppressive activity via downregulating NFATc2 in GBM . - pubmed
Bromodomain and extraterminal domain inhibition synergizes with WEE1 - inhibitor AZD1775 effect by impairing nonhomologous end joining and enhancing DNA damage in nonsmall cell lung cancer . - pubmed
Bromodomain and extraterminal domain ( BET ) inhibitors are broadly active against distinct types of cancer , including nonsmall cell lung cancer ( NSCLC ) . - pubmed
Thus , we hypothesized that BET inhibition would increase AZD1775 - induced cytotoxicity by impairing DNA damage repair . - pubmed
Here , we demonstrate that combined inhibition of BET and WEE1 synergistically suppresses NSCLC growth both in vitro and in vivo . - pubmed
Our findings reveal that BET proteins , predominantly BRD4 , play an essential role in DSB repair through the NHEJ pathway , and further suggest that combined inhibition of BET and WEE1 could serve as a novel therapeutic strategy for NSCLC . - pubmed
As such , decreased expression of either GATA4 , 5 , or 6 results in impaired cardiovascular homeostasis and increased risk of premature and serious cardiovascular events such as hypertension , arrhythmia , aortopathy , and heart failure . - pubmed
At the molecular level , hypoxia manifests its effects via activation of HIF - dependent transcription . - pubmed
p53 and HIF-1alpha are known to share a mysterious relationship and play an ambiguous role in the regulation of hypoxia - induced cellular changes . - pubmed
This p53 - induced chaperoning of HIF-1alpha increases synthesis of HIF - regulated genes and thus the efficiency of hypoxia - induced molecular changes . - pubmed
DIAGNOSIS : Blood routine examination , erythrocyte sedimentation rate , C - reactive protein , and magnetic resonance imaging ( MRI ) of the lumbar spine indicated lumbar pyogenic spondylodiscitis . - pubmed
Effect of pemafibrate , a novel selective peroxisome proliferator - activated receptor - alpha modulator ( SPPARMalpha ) , on urinary protein excretion in IgA nephropathy with hypertriglyceridemia . - pubmed
This paper is the first to show that 12 months of pemafibrate ( 0.1 mg daily ) administration in three drug - naive and mild IgAN patients with variable renal dysfunction and histopathology proven IgAN decreased serum triglyceride level and excretion of urinary protein and liver - type fatty acid - binding protein with no change in estimated glomerular filtration rate ( eGFR ) . - pubmed
Although sCr is a commonly accepted clinical standard , cystatin C ( CysC ) has shown superiority in assessment of renal function in disease states characterized by muscle wasting . - pubmed
CONCLUSIONS : The majority of patients initiated monotherapy treatment for PAH , most often a phosphodiesterase 5 inhibitor ( PDE5i ) . - pubmed
Halving Time of BCR - ABL1 in Chronic Myeloid Leukemia : Is It Better Than Day-90 Value - A Multicenter Study From South India . - pubmed
BACKGROUND : The 90 - day BCR - ABL1 ( breakpoint cluster region - Abelson 1 ) level has been one of the accepted milestones for predicting the molecular response in patients with chronic myeloid leukemia ( CML ) . - pubmed
Therefore , we tested the accuracy of the rate of decline of BCR - ABL1 in predicting the molecular response compared with the single 90 - day values in a retrospective cohort study of selected cancer centers in south India . - pubmed
METHODS AND MATERIALS : Patients with chronic - phase CML diagnosed from January 2013 to December 2018 , the serial BCR - ABL1 levels were estimated at 0 , 45 , and 90 days , 6 months , and 1 year . - pubmed
CONCLUSIONS : The halving time of BCR - ABL1 appears promising as a predictor of the outcomes for patients with CML . - pubmed
Inherited DNA mismatch repair ( MMR ) defects cause predisposition to colorectal , endometrial , ovarian , and other cancers occurring in Lynch syndrome ( LS ) . - pubmed
Microsatellite and MMR protein analysis stratified LS - BCs into MMR - deficient ( dMMR , n = 11 ) and MMR - proficient ( pMMR , n = 9 ) subgroups . - pubmed
All but one dMMR LS - BCs were hypermutated ( > 10 non - synonymous mutations / Mb ; average 174 / Mb per tumor ) and the frequency of MMR - deficiency - associated signatures 6 , 20 , and 26 was comparable to that in LS - OC and LS - CRC . - pubmed
In conclusion , somatic mutational signatures suggest that conventional MMR status of tumor tissues is likely to underestimate the significance of the predisposing MMR defects as contributors to breast tumorigenesis in LS . - pubmed
BACKGROUND : Tay - Sachs disease ( TSD ) , a type of GM2 - gangliosidosis , is a progressive neurodegenerative lysosomal storage disorder caused by mutations in the alpha subunit of the lysosomal beta - hexosaminidase enzyme . - pubmed
Recently , an early onset Tay - Sachs disease mouse model , with genotype Hexa-/-Neu3-/- , was generated . - pubmed
Behavioral tests demonstrated a high level of anxiety , and age - dependent loss in both spatial learning and fear memory in Hexa-/-Neu3-/- mice compared with that in the controls . - pubmed
CONCLUSION : Altogether , our data suggest that Hexa-/-Neu3-/- mice display a phenotype similar to Tay - Sachs patients suffering from chronic neuroinflammation triggered by GM2 accumulation . - pubmed
Tree shrews developed bleomycin - induced pulmonary fibrosis with architectural distortion in parenchyma and widespread collagen deposition . - pubmed
Thus , TTP must be suspected in patients with microangiopathic hemolytic anemia and thrombocytopenia , and plasma therapy must be initiated as soon as possible after ordering the ADAMTS13 test . - pubmed
Quercetin administration diminished the exudate and degree of inflammation in lamina propria of nasal and sinusal areas , parallel with the decreased secretion of TNF - alpha ( 40.2 % reduction after the low dose of LPS , and 35.4 % reduction after the high dose of LPS ) and IL-6 ( 21.4 % reduction after the low dose of LPS and 35.8 % reduction after the high dose of LPS ) . - pubmed
Flow cytometrically , abdominal fluid lymphocytes were highly positive for CD4 , CD5 , CD18 , CD45 , and MHC II , consistent with T cell lymphoma . - pubmed
Previous studies have presented evidence of shared idiotypic antigenic determinants located within the variable ( VH ) region of the heavy chains of monotypic IgMlambda and IgGkappa isolated from the serum of an individual patient , Bro , with Waldenstrom macroglobulinemia . - pubmed
Moreover , these findings extend the results of a previous study that has demonstrated the dual presence of IgGkappa and IgGlambda paraproteins within individual myeloma plasma cells . - pubmed
These findings may have a broad implication for the understanding of surface and cytoplasmic Ig markers of neoplastic lymphoid cells in certain other lymphoproliferative disorders . - pubmed
The plasma fibrinogen concentration is usually increased in inflammatory disorders and is thought to contribute to the ESR elevation , 6 - sulfanilamidoindazole induced arthritis in rats produces very high plasma fibrinogen concentrations and increased blood viscosity but no change in ESR . - pubmed
Pharmacological blockade of the action of glutamate at the N - methyl - D - aspartate ( NMDA ) receptor , ( the glutamate receptor subtype principally involved in the neurotoxic effects of the amino acid ) provides a novel therapeutic approach to cerebral ischaemia . - pubmed
The effects of NMDA receptor antagonists in animal models of focal cerebral ischaemia are uniquely consistent , viz , a marked reduction in the amount of irreversible ischaemic damage irrespective of the species , the model of cerebral ischaemia , when the animals are sacrificed after the ischaemic episode , whether ischaemia is permanent or temporary and followed by reperfusion and which particular NMDA antagonist was employed . - pubmed
The data which are reviewed provide the basis for the current clinical evaluation of NMDA receptor antagonists in stroke and head trauma . - pubmed
[ Analysis of deletions in the dystrophin gene by the multiplex amplification method in patients suffering from Duchenne ' s muscular dystrophy ] . - pubmed
Amyotrophic lateral sclerosis : thyroid and prolactin hormone changes in thyrotropin - releasing hormone therapy . - pubmed
13 patients with amyotrophic lateral sclerosis ( ALS ) were treated with intravenous infusion of thyrotropin - releasing hormone ( TRH ) . - pubmed
[ Simultaneous determination of prostatic acid phosphatase and prostate - specific antigen in carcinoma of the prostate . - pubmed
Interferon in human infections with St. - pubmed
Interferons and viral infections . - pubmed
Mice receiving a single subcutaneous injection of 5 micrograms type IV or type I murine collagens , or murine laminin in complete Freund 's adjuvant mount a delayed - type hypersensitivity response characterized by a mononuclear cell infiltrate when challenged in the footpad with the sensitizing antigen . - pubmed
A cell line derived from a human fibrosarcoma produced SP1 at rates exceeding that of the normal fibroblasts , but PP5 production was not detected in the fibrosarcoma . - pubmed
Correlation of mean nuclear area with estrogen receptor content in aspiration cytology of breast carcinoma . - pubmed
The serological diagnosis of virus hepatitis A and B depends on the demonstration of the various virus antigens ( HA - antigen , HBs - antigen , HBe - antigen ) and on their corresponding antibodies ( HA- , IgG- and IgM - antibody , HBc - antibody , Hbe - antibody and HBs - antibody ) . - pubmed
Prealbumin rather than albumin is a more sensitive indicator of acute liver disease . - pubmed
The changes in serum prealbumin ( transthyretin ) and serum albumin in acute and chronic liver diseases were investigated . - pubmed
Albumin has long been used as a useful indicator of liver function but serum prealbumin has recently been noted for its clinical significance in acute liver diseases . - pubmed
Serum prealbumin concentrations and liver function tests ( albumin , bilirubin , alanine aminotransferase ) were determined on blood obtained from normal donors ( n = 148 ) and from patients suffering from liver diseases ( n = 78 ) such as acute viral hepatitis , chronic active hepatitis , cirrhosis and hepatoma . - pubmed
The mean serum prealbumin concentration in normal subjects was 29.6 + /- 4.82 mg / dl while the mean serum prealbumin concentration in patients with liver disease was greatly reduced ( acute viral hepatitis = 15.3 + /- 7.4mg / dl ; chronic active hepatitis = 10.2 + /- 6.6mg / dl ; cirrhosis = 9.9 + /- 6.4mg / dl and hepatoma = 10.7 + /- 4.2 ) . - pubmed
Albumin concentrations dropped slightly ( 13 % compared to control ) in acute viral hepatitis but dropped markedly ( 28 % compared to control ) in chronic liver diseases . - pubmed
The study suggests that serum prealbumin concentration might be a more sensitive indicator than albumin in assessing liver dysfunction in acute liver diseases . - pubmed
Coexpression of IL-2 and gamma - IFN enhances tumor immunity . - pubmed
Relation between blood pressure and hematocrit in anephric patients treated by means of recombinant DNA human erythropoietin . - pubmed
When different categories of obesity are compared , blood pressure and one or more of the lipids show an increasing trend but glucose or insulin level shows no significant change . - pubmed
Immunoblot analysis , using epidermal extract of normal human skin , revealed that these patients ' sera reacted only with bullous pemphigoid antigen with a molecular weight of 180 kDa ( BP180 ) . - pubmed
The relationship of BP180 to malignant tumours is discussed . - pubmed
BACKGROUND / AIMS : Knockout mice lacking mdr2 , the murine analogue of human MDR3 P - glycoprotein , develop chronic non - suppurative cholangitis . - pubmed
Recently , a deficiency in MDR3 messenger RNA ( mRNA ) has been reported in a subtype of progressive familial intrahepatic cholestasis . - pubmed
Thus , reduced MDR3 gene expression could be involved in human cholestatic liver diseases . - pubmed
Using this method we determined the MDR3 mRNA levels in 52 liver specimens from primary biliary cirrhosis ( n=11 ) , chronic hepatitis B ( n=5 ) , chronic hepatitis C ( n=14 ) , non - cholestatic cirrhosis ( n=9 ) and controls ( n=13 ) . - pubmed
CONCLUSIONS : We found no evidence for deficient or severely reduced intrahepatic MDR3 mRNA in primary biliary cirrhosis , nor were mRNA levels altered significantly by virus - induced inflammation or by cirrhosis . - pubmed
Why do so many cancer patients fail to respond to interferon therapy ? - pubmed
Since their first use in the clinic some 25 years ago , interferons ( IFNs ) have become accepted therapy in a range of cancer forms . - pubmed
[ The structure of the connective - tissue framework of the skin regenerate in rats during the trypsin and ronidase stimulation of wound healing ] . - pubmed
Formation of granulation tissue and scar was accelerated after daily 20 minutes treatment with 0.2 % trypsin and 0.1 % ronidase solutions as compared to that in control . - pubmed
Prior to the discovery in 1993 and 1994 of genes ( hMSH2 , hMLH1 , hPMS1 , hPMS2 ) known as mis - match repair genes or mutator genes , the diagnosis of HNPCC rested exclusively upon evaluation of clinical findings in concert with a well - documented and extended pedigree . - pubmed
This study was designed to determine whether the force - frequency effect on myocardial contractility , known to be importantly regulated by the adrenergic nervous system in experimental animals , can be enhanced by beta - adrenergic receptor stimulation in patients with heart failure . - pubmed
To investigate the role of Esp proteins in disease , mutations in espA and espB were constructed in rabbit EPEC serotype O103 and infection characteristics were compared to that of the wild - type strain using histology , scanning and transmission electron microscopy , and confocal laser scanning microscopy in a weaned rabbit infection model . - pubmed
Collectively , this study shows for the first time that the type III secreted proteins EspA and EspB are needed to form A / E lesions in vivo and are indeed virulence factors . - pubmed
Using the AOS cDNA from tomato ( Lycopersicon esculentum ) , in which the role of jasmonic acid in wound - induced defense gene activation has been best described , we examined the kinetics of AOS induction in response to wounding and elicitors , in parallel with that of the wound - inducible PIN II ( proteinase inhibitor II ) gene . - pubmed
The addition of silver thiosulfate , an ethylene action inhibitor , prevented the wound - induced expression of both AOS and PIN II . - pubmed
C - reactive protein was revealed as appropriate for diagnosis and follow - up of spondylitis . - pubmed
Gonadotropin - releasing hormone ( GnRH)-antagonists can suppress the pituitary hormone secretion completely within a few hours , allowing the avoidance of premature luteinization within controlled ovarian hyperstimulation ( COH ) for assisted reproductive technologies ( ART ) by midcycle administration . - pubmed
Without any doubt GnRH - antagonists have the potential to become the new standard for controlled ovarian hyperstimulation . - pubmed
Unfavorable HL was defined as the presence of at least two of the following poor prognostic factors : high lactate dehydrogenase level , large mediastinal mass ( greater than at least 33 % of the thoracic diameter ) , more than one extranodal site , low hematocrit level , and inguinal involvement . - pubmed
We report on such apyrase - mediated allele - specific primer extension ( AMASE ) assay as a method suitable for high - throughout resequencing and mutation detection in tumor suppressor genes and oncogenes . - pubmed
CONCLUSION : Clinicians should consider NSAID use in the differential diagnosis of lithium toxicity , monitor patients ' serum lithium concentrations during the initiation or discontinuation of NSAID therapy , and be aware that the selective COX-2 inhibitors can increase serum lithium concentrations leading to toxicity . - pubmed
Because SP - D specifically interacts with neutrophils that infiltrate the lung in response to acute inflammation and infection , we examined the hypothesis that the neutrophil - derived serine proteinases ( NSPs ): neutrophil elastase , proteinase-3 , and cathepsin G degrade SP - D. - pubmed
Using a mouse model of acute bacterial pneumonia , we observed the accumulation of SP - D at sites of neutrophil infiltration coinciding with the appearance of approximately 35 - kDa SP - D fragments in bronchoalveolar lavage fluids . - pubmed
Together , our data suggest that neutrophil - derived serine proteinases cleave SP - D at sites of inflammation with potential deleterious effects on its biological functions . - pubmed
Decreased expression of killer cell inhibitory receptors on natural killer cells in eutopic endometrium in women with adenomyosis . - pubmed
BACKGROUND : Increased expression of killer cell inhibitory receptors ( KIRs ) has been found on natural killer ( NK ) cells in peritoneal fluid in women with endometriosis . - pubmed
In this study , we tried to measure the expression of KIRs on NK and T cells in women with adenomyosis , in an attempt to find the possible role of KIRs in the development of adenomyosis . - pubmed
RESULTS : There was a decreased expression of NKB1 and GL183 on NK cells in the endometrium , but not in the myometrium , in women with adenomyosis . - pubmed
However , the expression of KIRs on T cells , either CD4 + or CD8 + , was not different in either myometrium or endometrium between women with and without adenomyosis . - pubmed
CONCLUSIONS : The expression of KIRs on NK cells was decreased in eutopic endometrium in women with adenomyosis . - pubmed
[ Hepatocyte apoptosis and the expression of Bcl-2 and Bax in Yin - jaundice rats ] . - pubmed
OBJECTIVE : To investigate the effects of Yinchen Shufu Decoction on hepatocyte apoptosis and the expression of its apoptosis - regulating gene Bcl-2 and Bax in Yin - jaundice rats . - pubmed
RESULTS : The rate of apoptosis cells in Yin - jaundice model group was higher significantly than that in Yang - jaundice model group and normal control group ( P<0.01 ) , the expression of Bcl-2 in Yinchen Shufu Decoction treatment group was higher significantly than that in Yin - jaundice model group ( P<0.01 or P<0.05 ) , and the expression of Bax in it was lower significantly than that in Ying - jaundice model group ( P<0.01 or P<0.05 ) . - pubmed
Erythrocyte glutathione and serum total glutathione - S - transferase in epilepsy . - pubmed
The metabolic syndrome was defined according to the National Cholesterol Education Program definition , and insulin sensitivity was calculated by use of the quantitative insulin sensitivity check index . - pubmed
RESULTS : Multiple logistic regression analyses showed an inverse relationship according to 1 sd increase for circulating TT [ odds ratio ( OR ) = 0.43 ; 95 % confidence interval ( CI ) , 0.32 - 0.59 ] , BT ( OR = 0.62 ; 95 % CI , 0.46 - 0.83 ) , SHBG ( OR = 0.46 ; 95 % CI , 0.33 - 0.64 ) , and DHEA - S ( OR = 0.76 ; 95 % CI , 0.56 - 1.02 ) with the metabolic syndrome . - pubmed
Linear regression analyses showed that higher TT , BT , and SHBG levels were related to higher insulin sensitivity ; beta - coefficients ( 95 % CI ) were 0.011 ( 0.008 - 0.015 ) , 0.005 ( 0.001 - 0.009 ) , and 0.013 ( 0.010 - 0.017 ) , respectively , whereas no effects were found for DHEA - S and E2 . - pubmed
Further adjustment for insulin levels and body composition measurements attenuated the estimates , and the associations were similar in the group free of cardiovascular disease and diabetes . - pubmed
CONCLUSIONS : Higher testosterone and SHBG levels in aging males are independently associated with a higher insulin sensitivity and a reduced risk of the metabolic syndrome , independent of insulin levels and body composition measurements , suggesting that these hormones may protect against the development of metabolic syndrome . - pubmed
MSH6 mutations and risk of uterine cancer . - pubmed
The anticonvulsant potency of the competitive antagonist of the N - methyl - D - aspartate ( NMDA ) receptor , 2 - amino-7 - phosphonoheptanoic acid ( APH ) was investigated in the model of epilepsy induced by systemic administration of metaphit ( 1 -( 1 -( 3 - isothiocyanatophenyl )- cyclohexyl )- piperidine ) . - pubmed
PURPOSE OF REVIEW : We have selectively reviewed some of the latest papers on the mechanistic role of C - reactive protein in atherosclerotic cardiovascular disease . - pubmed
The atherosclerotic lesion itself is another place where C - reactive protein could be produced . - pubmed
The biological effect of C - reactive protein on atherosclerosis development seems to encompass a complex network of interactions with other players in immunity and inflammation , such as the complement system , as well as a direct effect of C - reactive protein on the cells involved in lesion growth and development . - pubmed
The diagnosis of ZES is certain when the plasma gastrin is & gt;1000 pg / mL and the basal acid output is & gt;15 mEq / h in patients with an intact stomach , & gt;5 mEq / h in gastrectomised patients , or when the hypergastrinemia is associated with a pH & lt;2 . - pubmed
In conclusion , disruptions of the tight junctions observed in this study implicate host cell signaling pathways , including the phosphorylation of myosin light chain and the regulation of tight - junctional proteins claudin-4 and claudin-5 , in the pathogenesis of H. - pubmed
Chemokines direct endothelial progenitors into tumor neovessels . - pubmed
We unequivocally demonstrate integration of bone marrow cells into the tumor vasculature as a late event in carcinogenesis that temporally correlates with VEGF release by the tumor and mobilization of circulating EPC in the periphery . - pubmed
Moreover , we demonstrate a chemokine - dependent mechanism of EPC homing into tumor , whereby neovessels of late - stage tumors release a battery of CC chemokines , which direct CCR2(+ ) and CCR5(+ ) progenitors into the vasculature . - pubmed
In this study , the relationship between PV replication in the spinal cord , damage in the motor neurons and poliomyelitis - like paralysis was analysed in transgenic mice expressing the human PV receptor ( TgPVR21 ) . - pubmed
However , severe paralysis could also be observed with an apparently low lesion score , where as few as 5.3 x 10(2 ) motor neurons ( 1.4 % of the susceptible cells in the lumbar cord ) were infected by TE - PV - Fluc mc . - pubmed
DNA methylation markers of surfactant proteins in lung cancer . - pubmed
Normal lung tissues with a higher level of unmethylated SP - A1_1468 and SP - D_1170 CpG exhibited a higher level of SP - A1 and SP - D gene transcripts indicating that CpG methylation may play a role in gene expression . - pubmed
We speculate that SP - A1 and SP - D are subject to methylation / demethylation regulatory mechanisms and are involved in lung cancer pathogenesis by virtue of their function in innate host defense and/or regulation of inflammation . - pubmed
Studies conducted with cytokines and diamide ( a thiol - depleting agent ) confirmed that cytokines are active agents in LCM which may be responsible for inhibition of OL development via peroxisomal dysfunction and induction of oxidative stress . - pubmed
Collectively , these data provide evidence that the modulation of PPAR - alpha activity , thus peroxisomal function by NAC attenuates LPS - induced glial factors - mediated inhibition of OL development suggesting new therapeutic interventions to prevent the devastating effects of maternal infections . - pubmed
Transforming growth factor beta1 T29C gene polymorphism and hypertension : relationship with cardiovascular and renal damage . - pubmed
Distribution of T29C TGFbeta1 gene polymorphism was analysed in 260 hypertensive and 134 normotensive subjects . - pubmed
Circulating TGFbeta1 and procollagen type III levels , microalbuminuria , left ventricular geometry and function were evaluated in all the hypertensives subgrouped according to T29C TGFbeta1 gene polymorphism . - pubmed
Circulating TGFbeta1 by ELISA technique , procollagen type III by a specific radioimmunoassay , microalbuminuria by radioimmunoassay , left ventricular geometry and function by echocardiography were determined . - pubmed
Regarding T29C TGFbeta1 gene polymorphism , prevalence of TC or CC genotypes was significantly ( p<0.05 ) higher in hypertensives than normotensives . - pubmed
TC and CC hypertensives were characterized by a higher prevalence of subjects with microalbuminuria ( p<0.001 TC vs TT ; p<0.05 CC vs TT ) , left ventricular hypertrophy ( p<0.01 TC and CC vs TT ) , and by increased levels of procollagen type III ( p<0.05 TC and CC vs TT ) . - pubmed
TC hypertensives were also characterized by a significant increase ( p<0.05 ) of LVM and LVM / h(2.7 ) and of urinary albumin excretion ( p<0.05 ) values than those detectable in TT hypertensives . - pubmed
Our data suggest that T29C TGFbeta1 gene polymorphism was associated to clinical characteristics suitable to recognize hypertensives with a higher severity of hypertension . - pubmed
This is important because virus and tumor Ag - specific CD4 T cell responses are selectively impaired in several chronic viral infections and malignancies . - pubmed
Functional heterospecific memory CD4 T cells could also rescue secondary CD8 T cell responses in an experimental tumor model in which homospecific CD4 help was impaired . - pubmed
Co - culture with PZ stromal cells and transforming growth factor - beta1 ( TGF - beta1 ) increased the tumor growth of PC-3 cells in vitro and in vivo , as well as Bcl-2 expression . - pubmed
Activation of calpain-1 in human carotid artery atherosclerotic lesions . - pubmed
Our observation of autoproteolytic cleavage of the 80 kDa subunit of calpain-1 provided further evidence for enzyme activity in the plaque samples . - pubmed
CONCLUSION : These novel results suggest that calpain-1 is commonly active in carotid artery atherosclerotic plaques , and that calpain activity is colocalized with cell death and inversely associated with symptoms . - pubmed
To develop potential biomarkers for diagnosis , we have identified five novel genes ( CYP39A1 , GTF2A1 , FOXD4L4 , EBP , and HAAO ) that are hypermethylated in ovarian tumors , compared with the non - malignant normal ovarian surface epithelia , using the quantitative methylation - specific polymerase chain reactions . - pubmed
Tetrahydroxy stilbene glucoside reduces the cognitive impairment and overexpression of amyloid precursor protein induced by aluminum exposure . - pubmed
The present study aims to evaluate the effects of tetrahydroxy stilbene glucoside ( TSG ) , the extract from herbal medicine Polygoni Multiflori , on cognitive impairment and the over - expression of hippocampal amyloid precursor protein ( APP ) induced by chronic exposure to Al in rats . - pubmed
c - Jun activation is required for 4 - hydroxytamoxifen - induced cell death in breast cancer cells . - pubmed
The c - Jun N - terminal kinase ( JNK ) has been shown to mediate tamoxifen - induced apoptosis in breast cancer cells . - pubmed
In this study , we analysed whether c - Jun , the major nuclear target of JNK , has a role in tamoxifen - induced apoptosis of SkBr3 breast cancer cells . - pubmed
Furthermore , both c - Fos expression and c - Jun N - terminal phosphorylation preceded OHT - dependent activation of caspase 3 - 7 in different types of tamoxifen - sensitive cancer cells , but not in OHT - resistant LNCaP prostate cancer cells . - pubmed
Taken together , our results indicate that the c - Jun / c - Fos AP-1 complex has a pro - apoptotic role in OHT - treated cancer cells and suggest that pharmacological boosts of c - Jun activation may be useful in a combination therapy setting to sensitize cancer cells to tamoxifen - mediated cell death . - pubmed
Vaccination with TCL plus MHSP65 induces anti - lung cancer immunity in mice . - pubmed
Our results showed that MHSP65 - TCL immunization significantly inhibited the growth of lung cancer in mice and prolonged the survival of lung cancer bearing mice . - pubmed
In vivo and in vitro data suggest that MHSP65 - TCL could induce specific CTL responses and non - specific immunity , both of which could contribute to the tumor inhibition . - pubmed
2 - Amino-3,8 - dimethylimidazo [ 4,5 - f ] quinoxaline ( MeIQx)-induced hepatocarcinogenesis is not enhanced by CYP1A inducers , alpha - and beta - naphthoflavone : relationship to intralobular distribution of CYP1A expression . - pubmed
Therefore , we here investigated the effects of alpha - and beta - naphthoflavone as CYP1A2 inducers on MeIQx - induced rat hepatocarcinogenesis in a medium - term rat liver bioassay . - pubmed
Unexpectedly , no modifying influence of naphthoflavones on MeIQx - induced hepatocarcinogenesis was demonstrated with reference to glutathione S - transferase placental form ( GST - P ) positive foci in the liver , although up - regulation of CYP1A2 was detected on Western blot analysis . - pubmed
TBI animals had an increase in intestinal tumor necrosis factor - alpha 6 hours after injury compared with vagal stimulation + TBI ( 45.6 + /- 8.6 pg / mL vs. 24.1 + /- 1.4 pg / mL ; p & lt ; 0.001 ) . - pubmed
TBI increased intestinal GFAP 6.2 - fold higher than sham at 2 hours and 11.5 - fold higher at 4 hours after injury ( p & lt ; 0.05 ) . - pubmed
Intestinal GFAP in vagal stimulation + TBI animals was also 6.7 - fold higher than sham at 2 hours , however , intestinal GFAP was 18.0 - fold higher at 4 hours compared with sham and 1.6 - fold higher than TBI alone ( p & lt ; 0.05 ) . - pubmed
Crizotinib for EML4 - ALK positive lung adenocarcinoma : a hope for the advanced disease ? - pubmed
Anaplastic lymphoma kinase inhibition in non - small - cell lung cancer . - pubmed
INTRODUCTION : In lung adenocarcinoma , certain mutations such as echinoderm microtubule - associated protein - like 4 - anaplastic lymphoma kinase ( ALK ) are associated with lower sensitivity to chemotherapy , when used conventionally as the first - line therapy in the advanced stage of the disease . - pubmed
AREAS COVERED : This paper discusses the clinical and therapeutic importance of ALK mutations in NSCLC and the early clinical results of a Phase I study assessing crizotinib in patients with ALK mutations . - pubmed
EXPERT OPINION : Abnormal ALK is evolving as an important therapeutic target in patients with more aggressive lung adenocarcinoma . - pubmed
The activity of thrombin is central to the processes of fibrin generation and platelet aggregation , which are inherent in thrombus formation . - pubmed
OBJECTIVE : To investigate the influence of Drynaria total flavonoids on proliferation and apoptosis of osteoblasts in tumor necrosis factor - alpha ( TNF - alpha)- mediated medium , so as to explore the mechanism of Drynaria total flavonoids in preventing and treating osteoporosis of rheumatoid arthritis . - pubmed
CONCLUSION : In TNF - alpha - mediated inflammatory environment , Drynaria total flavonoids can promote the proliferation and decrease the apoptosis of osteoblasts by improving the ratio of Bcl-2 mRNA to Bax mRNA , which may be one of the mechanisms of Drynaria total flavonoids in preventing and treating osteoporosis of rheumatoid arthritis . - pubmed
Finally , our results show that mutations in ATL1 causing hereditary spastic paraplegia compromise homotypic ER fusion . - pubmed
CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(- ) and thereby promotes tumor growth . - pubmed
CD44 is an adhesion molecule expressed in cancer stem - like cells . - pubmed
Human gastrointestinal cancer cells with a high level of CD44 expression showed an enhanced capacity for GSH synthesis and defense against reactive oxygen species ( ROS ) . - pubmed
Ablation of CD44 induced loss of xCT from the cell surface and suppressed tumor growth in a transgenic mouse model of gastric cancer . - pubmed
These findings establish a function for CD44v in regulation of ROS defense and tumor growth . - pubmed
It plays an essential role during branching morphogenesis of the metanephric kidneys , as mice with a targeted deletion of the Fgfrl1 gene show severe kidney dysplasia . - pubmed
A blood cell type termed crystal cell in Drosophila functions in clotting and wound healing and requires Notch for specification and maintenance . - pubmed
This interaction initiates in early endosomes , is independent of Hif - beta ( Tauangomicron in Drosophila ) , and does not activate hypoxia response targets . - pubmed
It was recently reported that mutation of CRY in p53 - null mice delayed the onset of cancer . - pubmed
It was therefore suggested that CRY mutation may activate p53 - independent apoptosis pathways , which eliminate premalignant and malignant cells and thus delay overt tumor formation . - pubmed
These findings provide a mechanistic foundation for the delayed onset of tumorigenesis in clock - disrupted p53 mutant mice and suggest unique therapeutic strategies for treating cancers associated with p53 mutation . - pubmed
for positron emission tomography ( PET ) of HER2 - expressing tumors ( 1 ) . - pubmed
The radiolabeled MUT - DS derivatives exhibited favorable pharmacokinetics for both imaging and therapy of HER2 - expressing tumors . - pubmed
TLR2 / MyD88 / NF - kappaB pathway , reactive oxygen species , potassium efflux activates NLRP3 / ASC inflammasome during respiratory syncytial virus infection . - pubmed
Interleukin-1beta ( IL-1beta ) plays an important role in inflammation by orchestrating the pro - inflammatory response . - pubmed
Although RSV infection results in IL-1beta release , the mechanism is unknown . - pubmed
Here in , we have characterized the mechanism of IL-1beta secretion following RSV infection . - pubmed
Our study revealed that NLRP3 / ASC inflammasome activation is crucial for IL-1beta production during RSV infection . - pubmed
TLR2 / MyD88 / NF - kappaB signaling is required for pro - IL-1beta and NLRP3 gene expression during RSV infection . - pubmed
PolyIC GE11 polyplex inhibits EGFR - overexpressing tumors . - pubmed
PolyIC / PPGE11 has a similar strong antitumor effect against EGFR overexpressing tumors in vitro and in vivo , as polyIC / polyethyleneimine - polyetheleneglycol - EGF ( polyIC / PP - EGF ) . - pubmed
Absence of EGFR activation , as previously shown by us and easier production of GE11 and GE11 conjugates , confer polyIC / PPGE11 a significant advantage over similar EGF - based polyplexes as a potential therapy of EGFR overexpressing tumors . - pubmed
Penetrance of PD in Glucocerebrosidase Gene Mutation Carriers . - pubmed
Phosphorylation of connexin43 on S279/282 may contribute to laminopathy - associated conduction defects . - pubmed
We conclude that increased pS279/282 Cx43 in the Lmna(-/- ) background results in decreased cell communication and may contribute to the arrhythmic pathology in vivo . - pubmed
TGF - beta1 enhances tumor - induced angiogenesis via JNK pathway and macrophage infiltration in an improved zebrafish embryo / xenograft glioma model . - pubmed
TGF - beta1 enhanced glioma - induced angiogenesis , which was inhibited by JNK inhibitor SP600125 but not p38 MAPK inhibitor SB202190 , ERK inhibitor PD98059 , or PI3 K inhibitor LY294002 , indicating the important role of TGF - beta1 and JNK pathways in this process . - pubmed
Moreover , the glioma - induced angiogenesis was associated with macrophage infiltration that was further enhanced by TGF - beta1 . - pubmed
The syndrome of heparin - induced thrombocytopenia ( HIT ) , with an incidence of 0.2 - 0.5 % in patients exposed to heparin for more than 4 days , is produced by an immune alteration with the formation of antibodies against the heparin platelet factor 4 complex . - pubmed
Dabigatran , a new anticoagulant medicine that is a direct and reversible thrombin inhibitor , could theoretically be a medicine employed in treating HIT . - pubmed
A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients . - pubmed
DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy . - pubmed
RESULTS : IL4 - 590*T associated with an increased prevalence of HIV - SN including following correction for age , height and CD4 T - cell count . - pubmed
DISCUSSION : We identified a novel association between IL4 - 590*T and HIV - SN in African HIV - positive patients which warrants further investigation . - pubmed
Furthermore , overexpression of IKBKE correlates with elevated levels of pFOXO3a - S644 in primary lung and breast tumors . - pubmed
In one trial of 115 women , levothyroxine therapy to treat pregnant euthyroid ( normal thyroid function ) women with thyroid peroxidase antibodies was not shown to reduce pre - eclampsia significantly ( risk ratio ( RR ) 0.61 ; 95 % confidence interval ( CI ) 0.11 to 3.48 ) but did significantly reduce preterm birth by 72 % ( RR 0.28 ; 95 % CI 0.10 to 0.80 ) . - pubmed
AUTHORS ' CONCLUSIONS : This review found no difference between levothyroxine therapy and a control for treating pregnant euthyroid women with thyroid peroxidase antibodies for the outcome of pre - eclampsia , however a reduction in preterm birth and a trend towards reduced miscarriage with levothyroxine was shown . - pubmed
Effect of focal mild hypothermia on expression of MMP-9 , TIMP-1 , Tau-1 and beta - APP in rats with cerebral ischaemia / reperfusion injury . - pubmed
This study aimed to examine the effects of focal mild hypothermia on proteins associated with both extracellular ( matrix metalloproteinase-9 ( MMP-9 ) and tissue inhibitor of MMP-9 ( TIMP-1 ) ) and cellular damage ( Tau-1 and beta - amyloid precursor protein ( beta - APP ) ) to characterize the protective effects of hypothermia . - pubmed
The brains were collected at 6 , 12 , 24 , 48 and 72 hours after hypothermia to measure infarct volume ratio and to detect cells immunopositive for MMP-9 , TIMP-1 , Tau-1 and beta - APP , while neurological deficits were examined separately after 2 weeks . - pubmed
MAIN OUTCOMES AND RESULTS : Focal mild hypothermia had no effect on infarct volume ratio but expression of MMP-9 , TIMP-1 Tau-1 and beta - APP was decreased . - pubmed
CONCLUSIONS : Focal mild hypothermia has protective effects on cerebral ischaemia - reperfusion injury characterized by decreased expression of MMP-9 , TIMP-1 , Tau-1 and beta - APP , along with improvement of neurological function despite no changes in infarct volume . - pubmed
TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells . - pubmed
Metastatic rhabdomyosarcoma in children has a 5 - year event - free survival rate of & lt;30 % , and a recent clinical trial with irinotecan , a topoisomerase I inhibitor , failed to improve outcome . - pubmed
Using human tissue microarrays and gene expression arrays , a marked overexpression of TDP1 protein and mRNA in RMS tumors was observed . - pubmed
Critically , knockdown of TDP1 or inhibition of poly ( ADP - ribose ) polymerase-1 ( PARP-1 ) , an enzyme in the same complex as TDP1 , sensitized rhabdomyosarcoma cell lines to analogues of irinotecan . - pubmed
Interestingly , BRCA1 / 2 mutations or altered expression was not detectable in rhabdomyosarcoma cells ; however , TDP1 knockdown and PARP-1 inhibition alone were cytotoxic to a subset of rhabdomyosarcoma cells , suggesting that they harbor genetic lesions in DNA repair components that have synthetic lethal interactions with loss of TDP1 or PARP1 function . - pubmed
Furthermore , culturing embryonal rhabdomyosarcoma cells in serum / nutrient - restricted medium increased cellular cytotoxicity upon PARP-1 inhibition and was intrinsically cytotoxic to alveolar , though not embryonal rhabdomyosarcoma cells . - pubmed
The results of these studies suggest a compensatory role for TDP1 in rhabdomyosarcoma after topoisomerase - I based therapy and further demonstrate that TDP1 knockdown , PARP-1 inhibition , and dietary restriction have therapeutic validity . - pubmed
IMPLICATIONS : Selective targeting of TDP1 and/or PARP-1 in rhabdomyosarcoma induces cytotoxicity and sensitizes to DNA damaging agents . - pubmed
Elevation of amyloid beta - peptide ( Abeta ) is critically associated with Alzheimer disease ( AD ) pathogenesis . - pubmed
Abeta - induced synaptic abnormalities , including altered receptor trafficking and synapse loss , have been linked to cognitive deficits in AD . - pubmed
Recent work implicates a lipid critical for neuronal function , phosphatidylinositol-4,5 - bisphosphate [ PI ( 4,5 ) P2 ] , in Abeta - induced synaptic and behavioral impairments . - pubmed
Heterozygous deletion of Synj1 protected neurons from Abeta - induced synaptic loss and restored learning and memory in a mouse model of AD . - pubmed
The assay will enable identification of novel Synj1 inhibitors that have potential utility as chemical probes to dissect the cellular role of Synj1 as well as potential to prevent or reverse AD - associated synaptic abnormalities . - pubmed
Dp71 - null mouse is thus an excellent model to approach the study of retinal pathologies showing blood - retinal barrier permeability . - pubmed
Sunitinib is a multiple tyrosine kinase receptor inhibitor that is approved for the treatment of metastatic renal cell carcinoma ( RCC ) . - pubmed
CONCLUSIONS : Our results suggest that the PLS fraction has a protective effect against intestinal damage through mechanisms that involve the inhibition of inflammatory cell infiltration , cytokine releasing and lipid peroxidation . - pubmed
Inhibition of COX activity in young mice by ip injections of NSAIDs causes dwarfism . - pubmed
Many potential substrates of NEDD4 have been identified and NEDD4 has been shown to play a critical role in the regulation of a number of membrane receptors , endocytic machinery components and the tumour suppressor PTEN . - pubmed
Soluble VCAM-1 and E - selectin in PD patients : the additive value of the free diffusion coefficient in the assessment of local peritoneal production . - pubmed
Regulation of pulmonary graft - versus - host disease by IL-26+CD26+CD4 T lymphocytes . - pubmed
In the current study , we identified a novel effect of IL-26 on transplant - related obliterative bronchiolitis . - pubmed
Histologically , lung of HuCB mice exhibited obliterative bronchiolitis with increased collagen deposition and predominant infiltration with human IL-26(+)CD26(+)CD4 T cells . - pubmed
Moreover , although IL-26 is absent from rodents , we showed that IL-26 increased collagen synthesis in fibroblasts and promoted lung fibrosis in a murine GVHD model using IL-26 transgenic mice . - pubmed
Administration of Cav - Ig before or after onset of GVHD impeded the development of clinical and histologic features of GVHD without interrupting engraftment of donor - derived human cells , with preservation of the graft - versus - leukemia effect . - pubmed
These results therefore provide proof of principle that cGVHD of the lungs is caused in part by IL-26(+)CD26(+)CD4 T cells , and that treatment with Cav - Ig could be beneficial for cGVHD prevention and therapy . - pubmed
To analyze the mechanism of action of triterpenoids , we investigated intramitochondrial reactive oxygen species ( ROS ) , mitochondrial membrane potential , mitochondrial mass , mitochondrial dynamics and morphology , and Lon proteolytic activity in RKO human colon cancer cells , in HepG2 hepatocarcinoma cells and in MCF7 breast carcinoma cells . - pubmed
In joint analysis of 90,003 IBC and Cardiometabochip SNPs , rs1543654 in the region of KCNE1 predicted change in BDI scores at Year 1 in diabetes support and education ( beta = -1.05 , standard error [ SE ] = 0.21 , p = 6.9 x 10(-7 ) ) at the level of chip - wide significance , while also showing a nominal association with baseline BDI ( beta = 0.35 , SE = 0.16 , p = .026 ) . - pubmed
We identified KCNE1 as a potential novel locus associated with depressive symptoms . - pubmed
Frameshift Sequence Variants in the Human Lipase - H Gene Causing Hypotrichosis . - pubmed
Sequence analysis of the lipase H ( LIPH ) gene , mapped on chromosome 3q27.3 , led to the identification of a novel frameshift deletion variant ( c.932delC , p. Pro311Leufs*3 ) in one family and previously reported 2 - bp deletion ( c.659_660delTA ) in five other families , inherited hypotrichosis , and woolly hair in an autosomal recessive pattern . - pubmed
The study further extends the body of evidence that sequence variants in the LIPH gene result in hypotrichosis and woolly hair phenotype . - pubmed
It has been reported that lysosomal - associated membrane protein 2 ( LAMP2 ) and heat shock protein ( HSP ) 70 are two calpain substrates that promote LMP in cancer cells ; however , it was found that calpains were activated by glutamate , but only LAMP2 was subsequently degraded . - pubmed
Isoform 1 of TPD52 ( PC-1 ) promotes neuroendocrine transdifferentiation in prostate cancer cells . - pubmed
Previous studies confirmed that PC-1 contributes to malignant progression in prostate cancer with an important role in castration - resistant stage . - pubmed
We established for long - term PC-1 overexpression an inducible expression system derived from the prostate carcinoma cell line LNCaP. - pubmed
In summary , our data provide evidence for an involvement of PC-1 in NE transdifferentiation , frequently associated with castration resistance , which is a major therapeutic challenge in the treatment of advanced prostate cancer . - pubmed
Methylation status of DJ-1 in leukocyte DNA of Parkinson ' s disease patients . - pubmed
BACKGROUND : DJ-1 has been thought as a candidate biomarker for Parkinson ' s disease ( PD ) . - pubmed
Thus , in this study , we try to explore whether blood - based DNA methylation of DJ-1 could be used as a biomarker to differentiate PD patients from normal control ( NC ) , and whether DNA methylation could regulate DJ-1 expression in a SH - SY5Y cell model . - pubmed
RESULTS : CpG sites in these two CpG islands ( CpG1 and CpG2 ) of DJ-1 were unmethylated in both PD and NC group . - pubmed
CONCLUSIONS : Our results indicated that DNA methylation inhibitor did n't alter DJ-1 gene expression in SH - SY5Y cell model , and DNA methylation of DJ-1 promoter region in PBLs level might not be an efficient biomarker for PD patients . - pubmed
Molecular chromosome analysis was performed on fluorescence in situ hybridization in tissue sections from the tissue blocks in all cases for the purpose of this study ; a ratio greater than 2 was considered to represent murine double - minute 2 ( MDM2 ) amplification consistent with a diagnosis of ALT / WDL . - pubmed
RESULTS : Compared with model group , the contents of Scr and BUN in rats serum of drug groups were significantly decreased ( P & lt ; 0.05 ) , the sclerosis of glomerulus was ameliorated , the degree of saccular dilatation and the damage of tubules were alleviated , collagen distribution and interstitial fibrosis was obviously improved , while the expressions of TGF - beta1 , alpha - SMA and Collagen - I were decreased . - pubmed
Compared with Rehmanniae Radix Praeparata decoction group , the contents of Scr and BUN in rats serum of Rehmanniae Radix decoction group were lower , the decrease of collagen distribution and interstitial fibrosis were more obviously , while the expression of alpha - SMA was significantly decreased ( P & lt ; 0.05 ) . - pubmed
CONCLUSION : The effect of Rehmanniae Radix is more powerful than that of Rehmanniae Radix Praeparata on attenuating interstitial fibrosis , which may relative to downregulating the expressions of TGF - beta1 , alpha - SMA and Collagen - I. - pubmed
Renal cells under hyperglycemic or proteinuric conditions exhibit inactivation of cell defense mechanisms such as AMPK and autophagy , and activation of pathologic pathways such as mammalian target of rapamycin ( mTOR ) , endoplasmic reticulum ( ER ) stress , epithelial - to - mesenchymal transition ( EMT ) , oxidative stress , and hypoxia . - pubmed
As these pathologic pathways are intertwined with AMPK signaling , the potential benefits of metformin therapy in patients with type 2 diabetes would extend beyond its anti - hyperglycemic effects . - pubmed
Moreover , administration of SN50 ( specific inhibitor of NF - kappaB ) inhibited the PQ - induced inflammation - related effects in SH - SY5Y cells . - pubmed
The RUN domain Beclin-1 - interacting cysteine - rich - containing ( Rubicon ) protein is involved in the maturation step of autophagy and the endocytic pathway as a Beclin-1 - binding partner , but little is known regarding the role of Rubicon during viral infection . - pubmed
The Rubicon protein levels were elevated in peripheral blood mononuclear cells , sera and liver tissues from patients with hepatitis B virus ( HBV ) infection relative to those in healthy individuals . - pubmed
Both Tdp1 and Tdp2 inhibition could hypothetically potentiate the cytotoxicities of topoisomerase inhibitors . - pubmed
Enzyme inhibitory data and cytotoxicity data from human cancer cell cultures establish that modification of the lactam side chain of the 7 - azaindenoisoquinolines can modulate their inhibitory potencies and selectivities vs Top1 , Tdp1 , and Tdp2 . - pubmed
The monitoring of DNA damage by gamma - H2AX foci formation in human PBMCs ( lymphocytes ) and acute lymphoblastic leukemia CCRF - CEM cells documented significantly more DNA damage in the cancer cells vs normal cells . - pubmed
NASH- and NASH - related HCC - specific DNA methylation alterations , which were not evident in viral - N samples and 37 samples of HCC associated with HBV or HCV infection , were observed in tumor - related genes , such as WHSC1 , and were frequently associated with mRNA expression abnormalities . - pubmed
We have also established models for the functional screening of profibrotic and antifibrotic drugs based on cFB proliferation , myofibroblast activation , and pericellular collagen matrix formation , and models of hypoxia / reoxygenation with appropriate time course and media conditions to achieve consistent cell injury . - pubmed
Sigma-1 receptors control immune - driven peripheral opioid analgesia during inflammation in mice . - pubmed
Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs , so sigma-1 receptors constitute a biological brake to opioid drug - induced analgesia . - pubmed
Peroxiredoxin-1 of macrophage is critical for mycobacterial infection and is controlled by early secretory antigenic target protein through the activation of p38 MAPK . - pubmed
Early secretory antigenic target protein ( ESAT-6 ) is an important virulent factor which plays a crucial role in Mycobacterium tuberculosis ( MTB ) pathogenesis . - pubmed
Long noncoding RNA Lnc - EGFR promotes cell proliferation and inhibits cell apoptosis via regulating the expression of EGFR in human tongue cancer . - pubmed
Herein , the present study aimed to investigate the role of a newly - discovered Lnc , Lnc - EGFR in tongue cancer . - pubmed
The results showed that the transcript level of Lnc - EGFR was upregulated in patients with tongue cancer and in cultured tongue cancer cell lines . - pubmed
All of these results suggested the oncogenic potential of Lnc - EGFR , which was achieved by positive regulation of EGFR in human tongue cancer . - pubmed
The hAbetaPPswe - bearing offspring from Tg2576 mothers showed an aggravated AD - like phenotype . - pubmed
Such progeny , lacking any mutant amyloid precursor protein , constitutes a novel model to study maternal transmission of AD and , even more important , to discover early risk markers that predispose to the development of AD . - pubmed
In conclusion , these results suggest that Nano - C3 G can reduce UVB - induced epidermal damage through the p53 - mediated apoptosis signaling pathway . - pubmed
The method is specific for CKMB , and biomarkers for AMI ( such as cardiac troponin I and myoglobin ) and serum do not interfere . - pubmed
He was found on admission to be in cardiogenic shock with an elevated troponin and intermittent bifascicular block . - pubmed
It reduced the fibrosis - positive areas and the protein levels of collagen types I and III in the left atrium . - pubmed
SP promotes cell proliferation in esophageal squamous cell carcinoma through the NK1R / Hes1 axis . - pubmed
BACKGROUND : Substance P ( SP ) plays an important role in several types of cancer promotion and progression by binding to its preferential neurokinin 1 receptor ( NK1R ) . - pubmed
However , the clinical significance and downstream mechanism of NK1R in esophageal squamous cell carcinoma ( ESCC ) have not been elucidated . - pubmed
The aim of this study was to investigate the role of SP / NK1R in the proliferation of ESCC and to screen related downstream molecules . - pubmed
METHODS : In the current investigation , the expression of NK1R was detected via immunohistochemistry ( IHC ) , western blot ( WB ) analysis and real - time reverse transcription - polymerase chain reaction ( RT - qPCR ) in ESCC tissues and cell lines . - pubmed
The proliferation ability of SP / NK1R was assessed by cell counting kit-8 ( CCK-8 ) and colony formation assays and subcutaneous tumour formation in nude mice with EC109 cells . - pubmed
RESULTS : NK1R was upregulated in ESCC , and its overexpression correlated with larger tumour size , deeper tumour invasion , more perineural invasion and eventually caused poorer overall survival ( OS ) . - pubmed
Both intrinsic and SP - activated NK1R upregulation could promote the proliferation and clonogenic capacity of ESCC cells . - pubmed
In nude mice , tumour growth was suppressed by EC109 cells of NK1R downregulation . - pubmed
CONCLUSIONS : The significant role of NK1R in mediating ESCC cell proliferation depended on the activation of SP and might be related to the downstream regulation of Hes1 . - pubmed
Physiological effects of cellular hypoxia are sensed by prolyl hydroxylase ( PHD ) enzymes which regulate HIFs . - pubmed
We have shown that stabilization of HIF levels in adult mice through PHD2 enzyme silencing by RNA interference , or inducible recombination of floxed alleles , results in multi - lineage leukocytosis and features of autoimmunity . - pubmed
We have studied the inhibitory effects of linezolid and tedizolid and their potential recovery on ( i ) CYTox I expression ( subunit I of cytochrome c - oxidase ; encoded by the mitochondrial genome ) , ( ii ) cytochrome c - oxidase activity , and ( iii ) mitochondrial respiration ( Seahorse bioanalysis ) in two megakaryocytic cell lines ( UT-7 WT [ human acute megakaryoblastic leukemia cells ] and UT-7 MPL [ transduced to stably express the thrombopoietin ( TPO ) receptor ] ) . - pubmed
CONCLUSIONS : Tirofiban during CAS might provide peri - procedural myocardial protection and reduce myocardial injury as determined by serial troponin measurements . - pubmed
Fortunately , letermovir which targets the HCMV terminase complex rather than DNA polymerase with fewer adverse reactions has been approved to treat CMV infections in humans . - pubmed
The gene or RNA targeting approaches including the external guide sequences ( EGSs)-RNase , the clustered regularly interspaced short palindromic repeats ( CRISPR )/ CRISPR - associated protein 9 ( Cas9 ) system and transcription activator - like effector nucleases ( TALENs ) are being investigated to remove acute and/or latent CMV infections . - pubmed
Here we used a lambda - MYC transgenic model of endogenously growing B - cell lymphoma to analyze the requirements for effective therapy with immune checkpoint inhibitors . - pubmed
METHODS : Growth of spontaneous lymphoma was monitored in mice that received antibodies targeting programmed cell death protein 1 and cytotoxic T lymphocyte - associated protein-4 , and the role of different immune cell compartments and cytokines was studied by in vivo depletion experiments . - pubmed
Antibody treatment enhanced numbers , proliferation and IFN - gamma expression of NK cells in developing tumors . - pubmed
In the lymphoma model studied , successful therapy required both , tumor - directed T - cell responses and NK cells , which control , at least partly , tumor development through cytokine - induced tumor senescence . - pubmed
Immunohistochemically , paraffin - embedded sections from all eight CCTL were negative for cytokeratin ( CK ) , epithelial membrane antigen ( EMA ) , chromogranin , and vimentin . - pubmed
Of more practical importance , the combined absence of CK , EMA , and vimentin in formalin - fixed , paraffin - embedded CCTL virtually precludes confusion with renal cell carcinoma . - pubmed
Serum levels of transaminases in arrested animals were significantly elevated ( 258 - 322 % ) while blood urea nitrogen , creatinine , and creatine kinase were minimally affected , suggesting that the reduced clearance of MK-801 might be secondary to hepatic ischemic damage . - pubmed
use of radiohalogenated steroid estrogen - receptor ( ER ) ligands as a potential option for diagnosing and treating intra - abdominal , retroperitoneal , and distant sites of advanced ER - rich malignancies . - pubmed
Demonstration and characterization of a transient arthritis in rats following sensitization of synovial mast cells with antigen - specific IgE and parenteral challenge with specific antigen . - pubmed
We have developed a model of IgE - dependent , mast cell - mediated arthritis in rats . - pubmed
Within 5 minutes of intravenous injection of antigen , an acute , transient arthritis occurred in the test joints only , with swelling and extravasation of intravascular blue dye and 125I - labeled albumin , decreased numbers of stainable mast cells , and decreased histamine content of the joint synovium . - pubmed
These data show that IgE - dependent synovial mast cell degranulation causes a transient , nondestructive arthritis , reminiscent of lupus arthritis and intermittent hydrarthrosis . - pubmed
Clinical evaluation of steroid receptors in ovarian neoplasms . - pubmed
Estrogen and progesterone receptors were estimated in a total of 25 ovarian neoplasms . - pubmed
None of the benign tumors showed steroid receptors . - pubmed
In the preliminary experiments , we applied this method for determination of CCK content in the brain regions of adult rats treated with 6 - hydroxy - dopamine or in newborn rats subjected to anoxia , and showed that this system is applicable to detection of changes of endogenous CCK content . - pubmed
Neuroblastoma cells contain a trophic factor sharing biological and molecular properties with ciliary neurotrophic factor . - pubmed
High - speed supernatants of extracts from two neuroblastoma ( NB ) cell lines -- the mouse C 1300 N2a and the human IMR 32 - -mimic the effects of CNTF on identical target neurons . - pubmed
These data suggest that the inhibitory action and potency of nucleoside dialdehydes on neuroblastoma growth are independent of their capacity to undergo a kinase - mediated phosphorylation at the 5 ' position . - pubmed
On account of many literature reports about the definite correlation between high animal protein intake and cardiovascular diseases , we have studied the effect of a hyperproteic purified diet ( casein 40 % , lactalbumin 20 % ) on fetal and post - natal ( not further than 40th day ) stage of the rat , when cell subdivision process is faster and therefore damage by nutritional imbalance is certainly more serious . - pubmed
The irregular nephrographic phase was associated with a transient accumulation of platelets and fibrinogen in the kidney and with microscopically demonstrable transient thrombi in afferent arterioles and glomerular capillary tufts . - pubmed
[ Detection of anti - M antibodies by passive hemagglutination test in streptococcal infections in children ] . - pubmed
[ Fetal hemoglobin in blood diseases ] . - pubmed
[ Quantitative histophotometric study of liver dehydrogenase activity during temporary ischemia of the extremities ] . - pubmed
The increase in the activities of dehydrogenases under study in the course of a 3 - hour ischemia , and the decrease of these parameters in 6- and 12 - hour ischemia was discovered , that was determined as a compensatory response followed by the period of compensation exhaustion and the development of the period of complete exhaustion . - pubmed
[ An ACTH - secreting carcinoid tumor of the thymus . - pubmed
Aflatoxin M1 ( AFM1 ) , a metabolic hydroxylation product of aflatoxin B1 ( AFB1 ) , and the parent compound were comparatively assayed for DNA - damaging potency and genotoxicity in vivo in Drosophila melanogaster using , respectively , the mei-9a mei-41D5 DNA repair test and the mwh / flr3 wing spot test . - pubmed
Expression of mdr1 gene in human breast primary tumors and metastases . - pubmed
Expression of mdr1 gene has been evaluated in 34 tumor samples obtained from breast cancer patients who were classified according to their treatment , and clinical follow - up . - pubmed
mdr1 - RNA was never detected in 29 primary breast tumors including 5 samples from patients previously treated by 6 courses of 5 - fluorouracil , epirubicin , cyclophosphamide ( FEC ) . - pubmed
In conclusion , evaluation of mdr1 - RNA seemed to be of little interest in primary breast tumors . - pubmed
However , the concomitant presence of an mdr1 - RNA and a metastatic phenotype could give a new insight into the relationship between invasive and resistance properties of cancer cells . - pubmed
Taken together , these data suggest that the endoproteolytic cleavage of gp160 occurs in the ER or cis - Golgi network , and ER retention strategies can potentially be used in preventing the spread of HIV-1 infection in permissive cells . - pubmed
With the discovery of the obesity gene and its product , leptin , we reexamined this hypothesis from a new perspective . - pubmed
As delayed menarche and leanness are considered risk factors for osteoporosis , we also evaluated the relation between leptin and bone mass . - pubmed
Leptin may also mediate the effect of obesity on bone mass by influencing the periosteal envelope . - pubmed
Salt restriction : effects on lipids and insulin production in hypertensive patients . - pubmed
The object of the study was to evaluate blood pressure , insulin and glucose metabolism , and serum lipids in hypertensive patients , during 8 weeks on a moderately salt - restricted diet . - pubmed
The concept of a safe , immunocontraceptive vaccine using the zona pellucida glycoprotein 3 ( ZP3 ) as an immunogen has been marred by the appearance of ovarian dysfunction in several species . - pubmed
However , careful selection of epitopes on mouse ZP3 have demonstrated that it is possible to segregate contraceptive bone marrow - derived ( B)-cell epitopes from the cytotoxic thymus - derived ( T)-cell epitopes thought to be responsible for inducing ovarian disease . - pubmed
Loss of cyclin D1 in necrotic and apoptotic models of cortical neuronal degeneration . - pubmed
Role of S-100beta as potential autoantigen in an autoimmune disease of the inner ear . - pubmed
In Lewis rats , adoptive transfer of T cells specific for the calcium - binding protein S-100beta mediates experimental autoimmune encephalomyelitis , but surprisingly also induced a marked labyrinthitis associated with impairment of hearing . - pubmed
This suggests that transfer of S-100beta - specific T cells into susceptible animals could be a novel model to study autoimmunity of inner ear diseases . - pubmed
Bovine beta - casein antibodies in breast- and bottle - fed infants : their relevance in Type 1 diabetes . - pubmed
BACKGROUND : Bovine beta - casein is a cow 's milk protein that targets both humoral and cellular immune responses in patients with Type 1 diabetes and , to a lesser degree , also in normal subjects . - pubmed
In addition , beta - casein antibodies were measured in 37 prepubertal children with Type 1 diabetes and in 31 healthy children who were exposed to cow 's milk or dairy products to see whether differences in antibody titers exist in this young age group . - pubmed
Antibody levels to bovine beta - casein were also significantly higher in children with Type 1 diabetes compared to age - matched controls ( p=0.03 ) . - pubmed
By western blot analysis we confirmed specific binding to bovine beta - casein in bottle - fed infants , in children with Type 1 diabetes and in controls exposed to cow 's milk , but not in infants who were exclusively breast - fed . - pubmed
The class of drugs known as the 5 - HT3 receptor antagonists have become widely used for chemotherapy - induced nausea and vomiting , and are considered a standard part of care for moderately- and highly - emetogenic chemotherapy in combination with corticosteroids . - pubmed
More recently , oral 5 - HT3 receptor antagonists have demonstrated efficacy in the prevention of nausea and vomiting due to highly - emetogenic chemotherapy as well . - pubmed
Despite hyperinsulinemia , the activity level of this enzyme was significantly higher in db / db mice , and the mRNA level of hepatic 11beta - HSD1 was also significantly higher in db / db mice . - pubmed
The increased hepatic corticosterone concentration due to the elevation of 11beta - HSD1 and high plasma corticosterone concentration may antagonize the action of insulin and cause insulin resistance . - pubmed
AIMS : The primary objective of this study was to determine the efficacy and safety of lamivudine ( LAM ) therapy in patients with chronic HBV infection and contraindications to IFN therapy , nonresponders to IFN and patients with advanced liver fibrosis . - pubmed
CONCLUSIONS : The results indicate that monotherapy with lamivudine ( 150 mg daily ) for 48 weeks induces sustained inhibition of viral replication and normalisation of transminases in majority of patients with chronic HBV infection who did not respond to IFN , had contraindications to IFN therapy , and in those who had advanced liver fibrosis . - pubmed
Epsilon - amino caproic acid additive decreases fibrin bandage performance in a swine arterial bleeding model . - pubmed
epsilon - Amino caproic acid ( EACA ) , a lysine analog that inhibits the activity of plasmin , was added to Nycomed ( TC - S ) fibrin bandages , and the bandages were tested for hemostatic efficacy in a swine femoral artery bleeding model . - pubmed
Distribution of codon 129 genotype in human growth hormone - treated CJD patients in France and the UK . - pubmed
Since homozygosity MM at codon 129 of the prion protein gene is a recognised risk factor in all forms of Creutzfeldt - Jakob disease ( CJD ) , we studied the distribution of codon 129 polymorphism in patients in France and in the UK with CJD transmitted iatrogenically by human growth hormone . - pubmed
There is no evident explanation for this different distribution , which might be due to infection with different strains of prion in human growth hormone . - pubmed
[ Effect of long - acting ACTH on behavior of blood eosinophilia ] . - pubmed
TARTRATE - INHIBITED ACID PHOSPHATASE IN BENIGN PROSTATIC HYPERTROPHY AND IN PROSTATIC CANCER . - pubmed
Partial A ( 1 ) adenosine receptor agonists from a molecular perspective and their potential use as chronic ventricular rate control agents during atrial fibrillation ( AF ) . - pubmed
The challenges associated with designing a partial A ( 1 )- adenosine receptor agonist for providing chronic ventricular rate control during atrial fibrillation are many . - pubmed
CD4 - T - lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection . - pubmed
Tumour - expressed CD43 ( sialophorin ) mediates tumourmesothelial cell adhesion . - pubmed
Mesothelial cell intercellular adhesion molecule-1 ( ICAM-1 ) has recently been shown to play a role in tumour cell adherence to the peritoneum . - pubmed
However , solid tumours poorly express its most ubiquitous ligand , beta2 integrin . - pubmed
beta2 Integrin subunit and CD43 expression was assessed on a number of tumour cell lines . - pubmed
beta2 Integrin expression was not inducible on these tumour cell lines , but Western blotting demonstrated CD43 expression in all the cancer cell lines examined and cell surface expression was confirmed by flow cytometry . - pubmed
The anti - CD43 antibody significantly reduced adhesion of PSN-1 and SW1222 cells to HPMC , however beta2 integrin inhibition did not reduce tumour cell adhesion . - pubmed
CD43 is expressed by a variety of carcinoma cell lines , and plays a role in tumour cell - peritoneal adhesion probably via interactions with its putative ligand ICAM-1 . - pubmed
Regulation of multidrug resistance by ribosomal protein l6 in gastric cancer cells . - pubmed
The aim of this study was to explore the roles of RPL6 in multidrug resistance ( MDR ) in gastric cancer cells . - pubmed
Together , this work demonstrates that RPL6 could regulate MDR in gastric cancer cells by suppressing drug - induced apoptosis . - pubmed
A series of combretastatins substituted with epoxides , amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin . - pubmed
Paraoxonases and cardiovascular diseases : pharmacological and nutritional influences . - pubmed
PURPOSE OF REVIEW : To summarize the new articles published in the last year on paraoxonases , including their expression in cardiovascular diseases , and regulation by pharmacological and nutritional means . - pubmed
PON1 activity and mass are both reduced in cardiovascular diseases and the hypocholesterolemic drugs , statins , increase serum PON1 activity ( by reducing oxidative stress , or by upregulating hepatic PON1 expression ) . - pubmed
Some drugs and nutrients including dietary antioxidants and polyphenols considerably increase the activities of paraoxonases which , in turn , can reduce oxidative stress and atherosclerosis development . - pubmed
Treating OSA patients with continuous positive airway pressure can prevent or improve hypertension , reduce abnormal elevations of inflammatory cytokines and adhesion molecules , reduce excessive sympathetic tone , avoid increased vascular oxidative stress , reverse coagulation abnormalities , and reduce leptin levels . - pubmed
CD10 expression was evaluated in 45 patients with diagnosis of Diffuse large B - cell lymphomas . - pubmed
CD10 antigen expression may have importance as one of the prognostic factors in patients with diagnosis of diffuse large B - cell lymphomas . - pubmed
Sotos syndrome is a well - known anomaly syndrome characterized by overgrowth , characteristic facial gestalt , and developmental delay , and haploinsufficiency of the NSD1 gene has been revealed as one of the major genetic causes . - pubmed
We examined three cases with typical Sotos syndrome , which also were confirmed by genetic analysis with a specific probe for the NSD1 gene . - pubmed
Cytokeratin profiles of male breast cancers . - pubmed
The identification of distinct cytokeratin ( CK ) profiles ( basal as opposed to luminal cells ) helps to identify subsets of tumours with different clinical behaviour . - pubmed
The aim of this study was to investigate CK expression in male breast cancer . - pubmed
All cases expressing either CK5 / 6 or CK14 were invasive carcinomas of high nuclear and histological grade and were also larger compared with the tumours not expressing CK5 / 6 and CK14 . - pubmed
All tumours except three ( also negative for CK5 / 6 ) expressed CK18 and CK19 . - pubmed
The four basal - like tumours were negative for Her-2 expression . - pubmed
The expression of CK5 / 6 and CK14 identifies a subset of pathologically aggressive male breast cancers . - pubmed
MDM2 and HMGA2 amplification were found in a subset of stromal cells in the hamartomatous component and in most cells of the well - differentiated liposarcoma . - pubmed
No rearrangement HMGA2 was found in the pulmonary hamartoma component . - pubmed
PATIENTS AND METHODS : Using stem loop - primed reverse transcription and TaqMan quantitative real - time polymerase chain reaction , the expression of 156 mature miRNAs was evaluated using pooled granulocytes from PMF patients , either wild - type or JAK2(617V>F ) mutant with & gt;51 % allele burden , and control subjects . - pubmed
The gene for ARPKD ( PKHD1 ) is located on chromosome 6p12 and encodes a protein called fibrocystin / polyductin ( FPC ) , 1 of many proteins that are normally present at the primary cilia of the renal tubules and intrahepatic bile ducts . - pubmed
FPC probably works in conjunction with cellular proteins involved in autosomal dominant polycystic kidney disease that is , polycystin-1 and polycystin-2 , which are also located in the primary cilia . - pubmed
Genetic abnormalities in PKHD1 may result in structural and functional abnormalities of FPC , leading to cystic phenotype . - pubmed
Adult T cell leukemia is a mature CD4 + T cell malignancy which predominantly expresses CCR4 and is etiologically associated with human T cell leukemia virus type 1 ( HTLV-1 ) . - pubmed
The genes of penile development ( HOX , FGF , Shh ) and testicular determination ( WT1 , SRY ) and those regulating the synthesis [ luteinizing hormone ( LH ) receptor ] and action of androgen ( 5alpha reductase , androgen receptor ) can cause hypospadias if altered . - pubmed
Impairment of clathrin - mediated endocytosis via cytoskeletal change by epithelial to fibroblastoid conversion in HepG2 cells : a possible mechanism of des - gamma - carboxy prothrombin production in hepatocellular carcinoma . - pubmed
Des - gamma - carboxy prothrombin ( DCP ) has been well established as a hepatocellular carcinoma ( HCC ) tumor marker . - pubmed
Because , as previously reported , the down - regulation of E - cadherin or high serum DCP in HCC patients is associated with a high risk of vascular invasion , intra - hepatic metastasis and tumor recurrence , we examined if HCC cells might produce DCP by epithelial to fibroblastoid conversion ( EFC ) in vitro . - pubmed
A proteomic approach identified growth hormone - dependent nutrition markers in children with idiopathic short stature . - pubmed
This study used a pharmaco - proteomic approach in order to identify novel biomarkers that discriminate between short non - GH - deficient ( GHD ) children who show a good or poor growth response to GH treatment . - pubmed
CONCLUSION : Our results suggest that transthyretin and apolipoprotein A - II may have a role in GH sensitivity and could be used as markers to predict which short prepubertal children with ISS will show a good or poor response to GH treatment . - pubmed
METHODS : Key studies supporting the importance of surrogate markers as diagnostic and prognostic predictors of cardiovascular and renal clinical outcomes in hypertension , as well as what is known about the effects of renin - angiotensin - aldosterone system - blocking agents on these biomarkers were reviewed . - pubmed
RESULTS : Clinical data supporting the use of surrogate markers for heart failure , such as brain natriuretic peptide ( BNP ) and N - terminal prohormone BNP ; markers for renal function , such as urinary albumin to creatinine ratio ( UACR ) , urinary albumin excretion rates ( UAER ) , and creatinine , reflecting glomerular filtration ; and markers of cardiac remodeling , such as left ventricular hypertrophy and calculations of left ventricular mass index ( LVMI ) , were reviewed for their utility in improving prognosis and treatment efficacy . - pubmed
Finally , hypertension treatment with angiotensin - converting enzyme inhibitors , angiotensin receptor blockers , and potentially direct renin inhibitors can significantly improve outcomes predicted by surrogate markers . - pubmed
CONCLUSIONS : BNP , UACR , UAER , and LVMI , among others , have been increasingly established as valid surrogate markers with significant value for hypertension prognosis and therapy . - pubmed
Ki-67 protein expression in smokeless tobacco ( maras powder)-induced oral mucosal lesions . - pubmed
CONCLUSIONS : Our study has shown that MP may induce epithelial cell proliferation , and that there was a significant positive association of Ki-67 expression and grade of dysplasia in MP users . - pubmed
Resistance to transforming growth factor beta - mediated tumor suppression in melanoma : are multiple mechanisms in place ? - pubmed
Resistance to transforming growth factor ( TGF ) beta - mediated tumor suppression in melanoma appears to be a crucial step in tumor aggressiveness since it is usually coupled with the ability of TGFbeta to drive the oncogenic process via autocrine and paracrine effects . - pubmed
In melanoma , some models of resistance to TGFbeta have been suggested and will be described . - pubmed
PURPOSE : 68Ga - DOTA - DPhe1,Tyr3 - octreotate ( 68Ga - DOTATATE ) is a somatostatin analogue that shows high affinity for somatostatin receptor subtype 2 ( sst2 ) and has been used for imaging neuroendocrine tumours . - pubmed
Phospholipase C beta 1 expression in the dorsolateral prefrontal cortex from patients with schizophrenia at different stages of illness . - pubmed
OBJECTIVE : Our recent microarray study detected decreases in the expression of phospholipase C beta 1 mRNA in the dorsolateral prefrontal cortex from subjects with schizophrenia at different stages of illness . - pubmed
METHOD : We measured levels of mRNA and protein for phospholipase C beta 1 variant a and b using real - time PCR and western blot analysis , respectively , in the dorsolateral prefrontal cortex from subjects with schizophrenia , who had a short ( & lt ; 7 years ) or long ( & gt ; 22 years ) duration of illness . - pubmed
RESULTS : Compared to age / sex matched controls , levels of phospholipase C beta 1 variant a and b mRNAs were decreased ( -33 % and -50 % , respectively ) in short duration schizophrenia . - pubmed
There was no significant difference in the protein levels of either phospholipase C beta 1 variant in schizophrenia , irrespective of duration of illness ( variant a ; P = 0.84 , variant b ; P = 0.73 ) . - pubmed
CONCLUSION : Our data confirm that phospholipase C beta 1 transcript levels are decreased in the dorsolateral prefrontal cortex from subjects with schizophrenia . - pubmed
Intracerebral administration of brain - derived neurotrophic factor ( BDNF ) reduces severity of cataleptic freezing in mice with genetic predisposition to catalepsy . - pubmed
Single administration of brain - derived neurotrophic factor ( BDNF ) into the lateral ventricle of ASC mice ( Antidepressant Sensitive Catalepsy ) , a model of depression - like state , significantly decreased predisposition to cataleptic freezing in these animals . - pubmed
Medulloblastoma : clinicopathological correlates of SHH , WNT , and non - SHH / WNT molecular subgroups . - pubmed
This manuscript reports the validation of a novel diagnostic immunohistochemical method to distinguish SHH , WNT , and non - SHH / WNT tumors and details their associations with clinical , pathological and cytogenetic variables . - pubmed
A cohort ( n = 235 ) of medulloblastomas from patients aged 0.4 - 52 years was studied for expression of four immunohistochemical markers : GAB1 , beta - catenin , filamin A , and YAP1 . - pubmed
Immunoreactivity ( IR ) for GAB1 characterizes only SHH tumors and nuclear IR for beta - catenin only WNT tumors . - pubmed
IRs for filamin A and YAP1 identify SHH and WNT tumors . - pubmed
SHH , WNT , and non - SHH / WNT tumors contributed 31 , 14 , and 55 % to the series . - pubmed
All desmoplastic / nodular ( D / N ) medulloblastomas were SHH tumors , while most WNT tumors ( 94 % ) had a classic phenotype . - pubmed
Monosomy 6 was strongly associated with WNT tumors , while PTCH1 loss occurred almost exclusively among SHH tumors . - pubmed
MYC or MYCN amplification and chromosome 17 imbalance occurred predominantly among non - SHH / WNT tumors . - pubmed
Among patients aged 3 - 16 years and entered onto the SIOP PNET3 trial , outcome was significantly better for children with WNT tumors , when compared to SHH or non - SHH / WNT tumors , which showed similar survival curves . - pubmed
However , high - risk factors ( M+ disease , LC / A pathology , MYC amplification ) significantly influenced survival in both SHH and non - SHH / WNT groups . - pubmed
We describe a robust method for detecting SHH , WNT , and non - SHH / WNT molecular subgroups in formalin - fixed medulloblastoma samples . - pubmed
Common variation in GPC5 is associated with acquired nephrotic syndrome . - pubmed
Here we identify an association between variants in GPC5 , encoding glypican-5 , and acquired nephrotic syndrome through a genome - wide association study and replication analysis ( P value under a recessive model ( P(rec ) ) = 6.0 x 10(-11 ) , odds ratio = 2.54 ) . - pubmed
This study identifies GPC5 as a new susceptibility gene for nephrotic syndrome and implicates GPC5 as a promising therapeutic target for reducing podocyte vulnerability in glomerular disease . - pubmed
Urine IL-8 concentrations are known to be elevated in urinary tract infection ( UTI ) , as well as in vesicoureteral reflux ( VUR ) even in the absence of infection . - pubmed
In this study we further investigated urine IL-8 in infants with congenital anomalies of the kidneys and urinary tract and with antenatally diagnosed isolated pelvic dilatation . - pubmed
Urine IL-8 was measured in 159 infants aged 1 month to 1 year with acute UTI ( group A , n = 26 ) , resolved UTI ( group B , n = 16 ) , VUR without recent UTI ( group C , n = 44 ) , non - VUR congenital urinary anomalies without recent UTI ( group D , n = 30 ) , isolated antenatal pelvic dilatation ( group E , n = 14 ) and in infants without known urinary tract condition ( control group F , n = 29 ) . - pubmed
Compared with the control group , urine IL-8 was elevated in infants with acute UTI , VUR without acute UTI and congenital anomalies without acute UTI ( p & lt ; 0.0001 ; p & lt ; 0.005 ; and p = 0.027 respectively ) , but not in infants with resolved UTI or with antenatal pelvic dilatation . - pubmed
Urine IL-8 levels are elevated in a variety of infectious and non - infectious urinary tract conditions , and hence may serve as a sensitive but not specific screening biomarker of urinary tract diseases . - pubmed
Beta - cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus . - pubmed
In contrast to their normoglycaemic control littermates ( RIP - Cre(+/- ) Dicer1(Delta / wt ) ) , RIP - Cre(+/-)Dicer1(flox / flox ) mice ( RIP - Cre Dicer1(Delta / Delta ) ) developed progressive hyperglycaemia and full - blown diabetes mellitus in adulthood that recapitulated the natural history of the spontaneous disease in mice . - pubmed
Reduced insulin gene expression and concomitant reduced insulin secretion preceded the hyperglycaemic state and diabetes development . - pubmed
In conclusion , we have demonstrated that a beta - cell specific disruption of the miRNAs network , although allowing for apparently normal beta - cell development , leads to progressive impairment of insulin secretion , glucose homeostasis and diabetes development . - pubmed
The prescription drug memantine , identified as an NMDA receptor antagonist , prevented the post - anesthesia upper airways dysfunction and alleviated tauopathy in the nucleus ambiguus and Kolliker - Fuse . - pubmed
Thus , our experimental findings in a validated mouse model for tauopathy demonstrate the link between isoflurane anesthesia , earlier onset of tauopathy and earlier onset of functional deficits , highlight the implication of NMDA - receptors in the mechanisms mediating the adverse effects of isoflurane , and potentially identify safer protocols for anesthesia in patients with tauopathy . - pubmed
EGFR and KRAS mutational analysis and their correlation to survival in pancreatic and periampullary cancer . - pubmed
OBJECTIVES : Pancreatic and periampullary cancers have a high incidence of activating KRAS mutations . - pubmed
The aim of this study was to determine the incidence of KRAS and EGFR mutations in pancreatic and periampullary cancers and their relationship with survival . - pubmed
CONCLUSIONS : EGFR somatic mutations are rare in pancreatobiliary malignancies . - pubmed
Pharmacological mechanisms of 5 - HT3 and tachykinin NK1 receptor antagonism to prevent chemotherapy - induced nausea and vomiting . - pubmed
The introduction of 5 - HT ( 3 ) receptor antagonists in the 90s was a major advance in the prevention of acute emesis . - pubmed
In contrast , delayed emesis has been largely associated with the activation of neurokinin 1 ( NK ( 1 ) ) receptors by substance P. - pubmed
However , in 2003 , a new 5 - HT ( 3 ) receptor antagonist was introduced into the market ; unlike first generation 5 - HT ( 3 ) receptor antagonists , palonosetron was found to be effective in preventing both acute and delayed chemotherapy induced nausea and vomiting . - pubmed
The role of ADAM-8 in cancer and inflammatory diseases such as allergy , arthritis and asthma makes it an attractive target for drug development . - pubmed
PURPOSE : To investigate whether suppression of plasma estradiol and estrone sulfate levels by the aromatase inhibitors ( AIs ) anastrozole and letrozole is related to body mass index ( BMI ) in postmenopausal women with early estrogen receptor ( ER ) -positive breast cancer . - pubmed
Neurotransmitter CART as a New Therapeutic Candidate for Parkinson ' s Disease . - pubmed
In this article , we summarize recent progress in studies investigating the relationship between CART , dopamine , and the pathophysiology of PD , with a focus on mitochondria - related topics . - pubmed
METHODS : This study analyzed thrombi retrieved by mechanical thrombectomy from cerebral arteries in 48 consecutive patients with acute ischemic stroke for the presence of endothelial cells using CD34 antibodies . - pubmed
RESULTS : Of 48 thrombi analyzed , CD34 - positive cells were absent in 20 , present as isolated cells in 21 , and found in clusters in 7 thrombi . - pubmed
Altered ketones suggest that systemic metabolism may play a critical role in preventing neurological injury , while altered succinate provides a possible explanation for hypoxia - inducible factor 1 - alpha ( HIF-1alpha ) stabilization in HI injury . - pubmed
Unilateral intrastriatal administration of QA ( 300 nmol/4 microl ) significantly reduced body weight , impaired behavior ( locomotor activity , beam balance and memory performance ) , caused oxidative damage ( increased lipid peroxidation , nitrite concentration , depleted super oxide dismutase and reduced glutathione ) , demonstrated mitochondrial dysfunction ( decreased Complex - I , II , III , and IV activities ) , increased striatal lesion volume and altered the levels of TNF - alpha , caspase-3 as well as BDNF expression , as compared to sham group . - pubmed
IP deficiency inhibited starvation - induced hepatic gluconeogenesis , thus inhibiting the progression of diabetes , whereas hepatic overexpression of IP increased gluconeogenesis . - pubmed
We therefore conclude that suppression of IP modulation of hepatic gluconeogenesis through the PKA / CREB and PI3K - gamma / PKC - zeta / TRB3 / AKT pathways contributes to the effects of NSAIDs in diabetes . - pubmed
Decreased concentration of IL-35 in plasma of patients with asthma and COPD . - pubmed
BACKGROUND : IL-35 has been found to be involved in many inflammatory diseases in humans but its role in asthma and chronic obstructive pulmonary disease ( COPD ) is not clear . - pubmed
The plasma level of IL-35 in patients with asthma and COPD needs to be measured . - pubmed
OBJECTIVE : The aim of this study was to examine the plasma concentrations of IL-35 in newly diagnosed asthmatic and COPD patients and control subjects and investigate correlations of lung function , age , sex , smoking history with the levels of IL-35 in plasma in these diseases . - pubmed
RESULT : The median and the range of values for IL-35 were 118.55 pg / ml ( range 74.43~1767.22 pg / ml ) in patients with asthma , 136.09 pg / ml ( range 62.54~697.49 pg / ml ) in patients with COPD and 275.86 pg / ml ( range 26.11~1766.20 pg / ml ) in control subjects . - pubmed
The levels of IL-35 in plasma showed a positive correlation with FEV1 % and FVC% in asthmatic patients whose plasma IL-35 values were over 150 pg / ml . - pubmed
A positive correlation was also found between plasma IL-35 and FVC% in COPD patients whose plasma IL-35 values were over 150 pg / ml . - pubmed
CONCLUSIONS : These findings suggest that IL-35 may very probably be involved in the Th2 and Th17 mediated inflammation process of asthma and COPD . - pubmed
Cutaneous ulceration in dermatomyositis : association with anti - melanoma differentiation - associated gene 5 antibodies and interstitial lung disease . - pubmed
In multivariate analysis ulcers were significantly associated with anti - melanoma differentiation gene 5 ( anti - MDA5 ) antibodies ( odds ratio 10.14 , 95 % confidence interval 1.95 - 52.78 ; P = 0.0059 ) and this was greatest for ulcers located at the digital pulp . - pubmed
In patients with cutaneous ulcers , ILD risk was specifically increased only in patients with anti - MDA5 - positive antibodies . - pubmed
CONCLUSION : We confirmed the strong association between anti - MDA5 antibodies and cutaneous ulcers , with the novel finding that the association of cutaneous ulcers with ILD depends upon the presence of anti - MDA5 antibodies . - pubmed
Preferential accumulation of targeted PEGylated liposome - ICG was studied after intravenous administration in comparison to non - targeted PEGylated liposome - ICG using both fast growing ( 4T1 ) and slow growing ( HT-29 ) MUC-1 positive tumour models . - pubmed
Rapid accumulation was observed for targeted liposomes at early time points mainly in the periphery of the tumour volume suggesting binding to available MUC-1 receptors . - pubmed
Reduced size and macrophage content of advanced atherosclerotic lesions in mice with bone marrow specific deficiency of alpha 7 nicotinic acetylcholine receptor . - pubmed
All these observations are suggestive of a potential role of macrophage alpha7nAChR in atherosclerosis . - pubmed
However , recent studies that focused on the impact of hematopoietic deficiency of alpha7nAChR on early atherosclerotic lesions of low density lipoprotein receptor knockout ( LDLRKO ) mice , yielded controversial results . - pubmed
Here we used LDLR knockout mice transplanted with bone marrow from wild - type or alpha7nAChR knockout animals to revisit the effect of hematopoietic deficiency of alpha7nAChR on early lesions and to examine , for the first time , its impact on advanced plaques . - pubmed
These studies are the first in examining the impact of hematopoietic deficiency of alpha7nAChR on the characteristics of advanced atherosclerotic lesions in a mouse model of the disease and provide novel evidence underscoring a potential pro - atherogenic role of macrophage alpha7nAChR. - pubmed
The Prevalence of Anemia of Chronic Disease in Patients With Spinal Cord Injuries and Pressure Ulcers and the Impact of Erythropoietin Supplementation on Wound Healing : A Descriptive Pilot Study . - pubmed
Anemia of chronic disease ( ACD ) is thought to impair the responsiveness of erythroid progenitor cells , but research has shown treatment with recombinant human erythropoietin ( rhuEPO ) can improve patient hemoglobin levels and , subsequently , overall patient health status and quality of life . - pubmed
A prospective pilot study was designed to estimate the prevalence of ACD in outpatients with spinal cord injury ( SCI ) and chronic pressure ulcers ( PUs ) and examine the impact of rhuEPO on PU healing in this population . - pubmed
The charts of 49 SCI patients with PUs were reviewed ; of those , 17 had anemia ( hemoglobin & lt;110 g / L ) . - pubmed
This research indicates rhuEPO treatment may improve some outcomes for ACD - SCI PU patients , but larger randomized controlled trials are required . - pubmed
We previously reported that IL-6R , STAT3 and miR-34a form a positive feedback - loop , which promotes epithelial to mesenchymal transition ( EMT ) , invasion , and metastasis of colorectal cancer ( CRC ) [ 1 ] . - pubmed
Accordingly , the concentration of s - IL6R protein was decreased in conditioned media of CRC cell lines ectopically expressing miR-34a . - pubmed
Rho - GTPase and Atherosclerosis : Pleiotropic Effects of Statins . - pubmed
Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection . - pubmed
During infection , inhibition of the kinase resulted in elevated levels of p21 ( Cip1 ) in wild - type virus but not a pUL27 - deficient virus . - pubmed
In addition , these studies further support the notion that CDK inhibitors or p21 ( Cip1 ) activators might be useful in combination with MBV to effectively inhibit HCMV infections . - pubmed
Significance of FGF9 gene in resistance to anti - EGFR therapies targeting colorectal cancer : A subset of colorectal cancer patients with FGF9 upregulation may be resistant to anti - EGFR therapies . - pubmed
Although fibroblast growth factor ( FGF ) signals are strongly associated with malignancy , limited information is available regarding the role of the FGF9 signal in colorectal cancer ( CRC ) . - pubmed
In this study , we investigated the frequency of FGF9 amplification in CRC clinical specimens and the association between the FGF9 gene and resistance to anti - EGFR therapies . - pubmed
In both the in vitro and in vivo experiments using FGF9 - overexpressing CRC cell lines , FGF9 overexpression induced strong resistance to anti - EGFR therapies via the enforced FGFR signal , and this resistance was cancelled by the application of an FGFR inhibitor . - pubmed
Considering these results , the FGF9 gene may play an important role in resistance to anti - EGFR therapies in patients with CRC , and such resistance might be overcome by combined treatment with an anti - FGFR inhibitor . - pubmed
These findings strongly encourage the development of FGFR - targeted therapy for CRC patients with FGF9 gene upregulation . - pubmed
The total bilirubin , direct bilirubin and tumor markers ( CA-199 , CA-242 , CEA ) before and after surgery , the biliary stent patency status was assessed , and the survival time was evaluated . - pubmed
KEY WORDS : Angiogenesis ; Atherosclerosis ; nicotinic acetylcholine receptors ( nAChRs ) ; Nicotine . - pubmed
METHODS : Premenopausal women with estrogen receptor - positive breast cancer treated with definitive surgery were enrolled after completion of neoadjuvant or adjuvant chemotherapy . - pubmed
Ovarian function was assessed at the time of enrollment and every 6 months for 2 years by follicular - stimulating hormone levels and bleeding history . - pubmed
DISCUSSION : This study will provide evidence of the benefit of OFS plus tamoxifen compared with tamoxifen only in premenopausal patients with estrogen receptor - positive breast cancer treated with chemotherapy . - pubmed
Importantly , these data provide insight into a homeostatic mechanism in which C1q and HMGB1 can cooperate to terminate inflammation , and which may be impaired in C1q - deficient patients with autoimmune disease . - pubmed
Daratumumab ( DARA ) , a monoclonal antibody ( MoAb ) , was developed to treat relapsed / refractory multiple myeloma ( RRMM ) . - pubmed
Changes in interleukin-6 levels during electroconvulsive therapy may reflect the therapeutic response in major depression . - pubmed
OBJECTIVE : Interleukin-6 ( IL-6 ) has been reported to be elevated in major depressive disorder ( MDD ) but decreased by antidepressive medication . - pubmed
IL-6 levels are markedly elevated both after epileptic seizures and single electroconvulsive therapy ( ECT ) session , but long - term changes in IL-6 levels after ECT have not been studied . - pubmed
Interestingly , the long - term effect of ECT on IL-6 seems to correlate with outcome , providing further evidence of the mechanism of action of ECT and supporting the inflammation theory in MDD . - pubmed
Cystic Fibrosis ( CF ) is a disease caused by mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene . - pubmed
Lentiviral Transfer of gamma - Globin with Fusion Gene NUP98 - HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine beta - Thalassemia . - pubmed
Expression of PHLDA2 was higher in IVF than AI samples ( P<0.05 ) . - pubmed
The cytotoxic effect of PNC-27 was dependent on its binding to MDM-2 . - pubmed
A total of 120 overweight ( body mass index & gt;23 kg / m2 ) inpatients ( aged 20 - 70 years ) with a history of troponin - positive acute coronary syndrome ( ACS ) within the 1 month preceding the study will be recruited . - pubmed
Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension . - pubmed
Heterozygous mutations in the gene encoding the bone morphogenetic protein receptor type 2 ( BMPR2 ) are the commonest genetic cause of PAH , whereas biallelic mutations in the eukaryotic translation initiation factor 2 alpha kinase 4 gene ( EIF2AK4 ) are described in pulmonary veno - occlusive disease / pulmonary capillary hemangiomatosis . - pubmed
Biallelic mutations in EIF2AK4 were identified in 5 patients with a clinical diagnosis of pulmonary veno - occlusive disease / pulmonary capillary hemangiomatosis . - pubmed
Furthermore , 9 patients with a clinical diagnosis of PAH carried biallelic EIF2AK4 mutations . - pubmed
These patients had a reduced transfer coefficient for carbon monoxide ( Kco ; 33 % [ interquartile range , 30%-35 % ] predicted ) and younger age at diagnosis ( 29 years ; interquartile range , 23 - 38 years ) and more interlobular septal thickening and mediastinal lymphadenopathy on computed tomography of the chest compared with patients with PAH without EIF2AK4 mutations . - pubmed
Patients with PAH with biallelic EIF2AK4 mutations had a shorter survival . - pubmed
CONCLUSIONS : Biallelic EIF2AK4 mutations are found in patients classified clinically as having idiopathic and heritable PAH . - pubmed
The results revealed 39 mutations in the three esophageal cancer cell lines ; the genes with the highest mutation frequencies included mitochondrially encoded cytochrome B ( MT - CYTB ) , NADH dehydrogenase 5 ( MT - ND5 ) and MT - ND4 gene . - pubmed
A total of 216 mutations were identified in the 30 esophageal cancer tissues , including 182 protein - coding mutations , of which MT - CYTB and MT - ND5 genes exhibited higher mutation frequencies . - pubmed
The Achilles tendons of 16 weeks old female Sprague Dawley rats ( n = 40 ) were unloaded for 5 weeks by inducing muscle paralysis with botulinum toxin injections in the right gastrocnemius and soleus muscles . - pubmed
Thus , Rac GTPase and PAK proteins may serve as targets for treatment of fear and anxiety disorders . - pubmed
Myoglobulin released from dead muscle is shown to induce acute kidney injury through a mechanism dependent on platelets and macrophage extracellular traps . - pubmed
METHODS : In 58 hemodialysed patients with sHPT ( parathyroid hormone [ PTH ] & gt ; 300 pg / mL ) plasma Advanced Oxidation Protein Products ( AOPP ) , serum total antioxidant capacity - ImAnOx ( TAS / TAC ) , serum PTH , calcium and phosphate concentrations were assessed before the first dose of cinacalcet and after 6 months of treatment . - pubmed
MANF improves the MPP+/MPTP - induced Parkinson ' s disease via improvement of mitochondrial function and inhibition of oxidative stress . - pubmed
OBJECTIVE : This study aimed to investigate the therapeutic effect of mesencephalic astrocyte - derived neurotrophic factor ( MANF ) on the MPTP / MPP+-induced model of Parkinson ' s disease ( PD ) and the potential mechanism . - pubmed
A cell model of PD was established by incubating SH - SY5Y cells with MPP + , cells were pretreated for 2 h with different concentrations of MANF before 24 h incubation with MPP + . - pubmed
CONCLUSION : MANF can attenuate the neuronal lesion in MPTP / MPP+-induced PD mice , which may be related to the improvement of mitochondrial function and inhibition of oxidative stress . - pubmed
We immunize mice with myelin oligodendrocyte glycoprotein ( MOG ) , DNA - histone and DNA - methylated bovine serum albumin ( met - BSA ) complexes to reveal different characteristics of EAE development including bone marrow lymphocyte proliferation and differentiation profiles of hematopoietic stem cells . - pubmed
Immunization of C57BL / 6 mice with MOG35 - 55 results in the acceleration of EAE development . - pubmed
During the acute EAE phase ( 7 - 20 days after immunization ) , catalytic antibodies efficiently hydrolysing myelin basic protein ( MBP ) , MOG and DNA are produced with parallel suppression of antibodies hydrolysing histones . - pubmed
We could show that in contrast to MOG , immunization with histone - DNA results in a reduction of proteinuria , a significant increase in anti - DNA , anti - MBP and anti - MOG antibody titres , as well as an increase in their catalytic activities for antigen hydrolysis , but slightly changes the concentration of cytokines . - pubmed
DNA - histone stimulates the appearance of histone - hydrolysing abzymes in the acute EAE phase , while abzymes with DNase activity appear at significantly later time - points . - pubmed
We conclude that MOG , DNA - histone and DNA - met - BSA have different effects on numerous bone marrow , cellular , immunological and biochemical parameters of immunized mice , but all antigens finally significantly stimulate the development of the EAE . - pubmed
Combining DNA Vaccine and AIM2 in H1 Nanoparticles Exert Anti - Renal Carcinoma Effects via Enhancing Tumor - Specific Multi - functional CD8 + T - cell Responses . - pubmed
In this study , we designed a folate - grafted PEI600 - CyD ( H1 ) nanoparticle - mediated DNA vaccine containing an adjuvant of absent in melanoma 2 ( AIM2 ) and a tumor - specific antigen of carbonic anhydrase IX ( CAIX ) for renal carcinoma therapy . - pubmed
Mice bearing subcutaneous human CAIX ( hCAIX)-Renca tumor were intramuscularly immunized with H1 - pAIM2 / pCAIX , H1 - pCAIX , H1 - pAIM2 , or Mock vaccine , respectively . - pubmed
Lung metastasis of renal carcinoma was also suppressed by H1 - pAIM2 / pCAIX vaccine treatment accompanied with the increased percentages of CAIX - specific multi - functional CD8 + T cells in the spleen , tumor , and bronchoalveolar lavage as compared with H1 - pCAIX vaccine . - pubmed
Therefore , these results indicated that H1 - pAIM2 / pCAIX vaccine exhibits the therapeutic efficacy of anti - renal carcinoma by enhancing tumor - specific multi - functional CD8 + T - cell responses . - pubmed
PLCB1 Biallelic Point Mutations Cause West Syndrome . - pubmed
CONCLUSIONS : While the phenotype and true clinical effect of AMR remain to be better defined , the high prevalence of DSA and the correlation with acute rejection highlight the need for optimizing immunosuppression , close monitoring and the relevance of an HLA class II match in UET recipients . - pubmed
OBJECTIVE : To assess the safety and efficacy of crisaborole 2 % ointment - a nonsteroidal , phosphodiesterase-4 inhibitor - in the treatment of intertriginous , anogenital , and facial psoriasis . - pubmed
A study in nonhuman primates reported that infusions of an antibody against alpha4beta7 integrin , in combination with antiretroviral therapy , showed consistent , durable control of simian immunodeficiency virus ( SIV ) in rhesus macaques . - pubmed
Taken together , these findings suggest that low doses of active P1G10 promotes lesion resolution , at least in part by its anti - inflammatory activity , in TNBS - colitis model . - pubmed
The sialidase activity of NA is required for the release of nascent virus particles from infected cell membranes and inhibition of NA enzymatic activity can significantly reduce virus titers and duration of infection . - pubmed
RESULTS : Postoperatively , the concentrations of blood glucose declined , and the insulin sensitivity increased significantly in rats with diabetes . - pubmed
METHODS AND RESULTS : This study aimed to evaluate the capabilities of three methods for genotyping MTB isolates collected from Iran through comparing our previously published results for IS6110 - RFLP and PGRS - RFLP methods and current results obtained from IS6110 - Mtb1 / Mtb2 PCR technique . - pubmed
METHODS : SARS - CoV-2 antibodies were measured with the Elecsys assay and the EDITM ELISAs ( IgM and IgG ) in 64 SARS - CoV-2 RT - PCR confirmed COVID-19 patients with serial blood samples ( n = 104 ) collected at different time points from symptom onset . - pubmed
Prenatal androgen ( PNA ) exposure mimics reproductive dysfunction of the common fertility disorder polycystic ovary syndrome ( PCOS ) and reduces prepubertal GnRH neuron activity . - pubmed
This provides a clearer understanding of the role prepubertal GnRH neuron activity plays in establishing adult reproductive function and suggests additional androgen - dependent programming actions are required for complete reproductive disruption in this model and perhaps PCOS . - pubmed
Here we set out to characterize the expression status of LINC00426 in osteosarcoma and understand its mechanistic involvement in incidence of doxorubicin ( Dox ) resistance . - pubmed
RESULTS : LINC00426 was significantly up - regulated in Dox - resistant osteosarcoma ( OS ) both in vitro and in vivo , which intimately associated with unfavorable prognosis . - pubmed
We uncovered the important contribution of LINC00426 / miR-4319 to Dox resistance in osteosarcoma . - pubmed
Focal adhesion kinase ( FAK ) is one kind of tyrosine kinases that modulates integrin and growth factor signaling pathways , which is a promising therapeutic target because of involving in the migration , proliferation and survival of cancer cell . - pubmed
Overexpression and amplification of cyclin - dependent kinase 4 / 6 ( CDK4 / 6 ) occur in many cancers and may be the cause of resistance to CDK4 / 6 inhibitors in preclinical models . - pubmed
N - acetylgalactosaminyltransferase : a potential target for colorectal adenocarcinoma . - pubmed
We employed cystathionine beta synthase ; CBS deficient mouse ; CBS+/- fed with / without HMD and with / without a probiotic in drinking water for 16 weeks . - pubmed
Identification of a novel KMT2A / GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia . - pubmed
While commonly observed in several acute leukemias , KMT2A rearrangements in AUL have been rarely reported in the literature . - pubmed
We report the third case to our knowledge of AUL harboring a KMT2A rearrangement . - pubmed
Wnt Signaling Shapes the Histological Variation in Diffuse Gastric Cancer . - pubmed
For genetic modeling of diffuse gastric cancer , we knocked out CDH1 and/or TP53 in human normal gastric organoids . - pubmed
The transition from PCC - NOS to SRCC histology reflected the abundance of surrounding R - spondin - expressing fibroblasts . - pubmed
CONCLUSIONS : SRCC and PCC - NOS were clonally identical , and their morphology was regulated by extracellular Wnt and R - spondin expression . - pubmed
BACKGROUND : We performed exploratory analyses of retinal thickness data from a clinical trial of the AbetaPP cleaving enzyme ( BACE ) inhibitor verubecestat in patients with Alzheimer ' s disease ( AD ) . - pubmed
OBJECTIVE : To evaluate : 1 ) possible retinal thickness changes following BACE inhibition ; and 2 ) possible association between retinal thickness and brain atrophy . - pubmed
CONCLUSION : BACE inhibition by verubecestat was not associated with adverse effects on retinal thickness in patients with mild - to - moderate AD . - pubmed
ACTH - secreting lung tumours . - pubmed
delta - aminolaevulinic acid dehydratase activity and focal brain haemorrhages in lead - treated rats . - pubmed
It is concluded that damage to the rat brain vascular system is a better index of lead toxicity than measurement of the lead sensitive enzyme ALA dehydratase . - pubmed
Effects of endothelin in portal hypertensive rats . - pubmed
Effects of endothelin-1 on systemic arterial blood pressure , heart rate and portal venous pressure were compared in normal Sprague - Dawley rats and rats with portal hypertension induced by CCl4 and partial portal vein ligation . - pubmed
The ability of endothelin-1 to increase the portal venous pressure was also significantly diminished in portal hypertensive rats . - pubmed
It was concluded that a lower plasma level of endothelin and a reduced vascular responsiveness may contribute , at least in part , to the hyperdynamics of portal hypertension . - pubmed
An important role of gamma interferon may be to protect lymphohaemopoietic cells from virus infection and destruction by cytopathic effects of either the virus or of anti - viral immunity . - pubmed
Differential factor binding at the promoter of early baculovirus gene PE38 during viral infection : GATA motif is recognized by an insect protein . - pubmed
Several factors would not seem to play an important prognostic role : age , liver function , alpha fetoprotein level or histological staging of the tumor . - pubmed
Serum transferrin levels in the longitudinal assessment of protein - energy status in preterm infants . - pubmed
c - H - ras-1 expression in 7,12 - dimethyl benzanthracene - induced Balb / c mouse mammary hyperplasias and their tumors . - pubmed
Dimethylbenzanthracene ( DMBA)-induced mouse mammary tumors characteristically contain an activated c - H - ras-1 gene with an A----T transversion in the 61st codon which is expressed as a rapidly migrating p21 c - H - ras . - pubmed
The role of the activated c - H - ras-1 locus in the initiation of mammary neoplasia was analysed by studying seven transplantable , DMBA - induced Balb / c premalignant mammary hyperplasias . - pubmed
The DNAs from these hyperplasias had no evidence of activation of the c - H - ras-1 gene . - pubmed
All of the tumors with the characteristic mutation expressed the corresponding rapid p21 c - H - ras . - pubmed
These data suggest that although c - H - ras-1 activation may play an important role in neoplastic progression , it had no definable role in the initiation or the maintenance of the mammary hyperplasias studied here . - pubmed
Linkage and segregation analyses of apolipoproteins A1 and B , and lipoprotein cholesterol levels in a large pedigree with excess coronary heart disease : the Bogalusa Heart Study . - pubmed
[ Behavior of CK - MB in uremic patients undergoing periodic hemodialytic treatment . - pubmed
[ Use of cocarboxylase in steroid diabetes mellitus ] . - pubmed
To study the mechanisms of the antiaggregation action of thyroxine and insulin , platelets obtained from patients with diffuse toxic goiter and from rabbits with experimental hyperinsulinemia were incubated with acetylsalicylic acid and indomethacin . - pubmed
Based on the data obtained a hypothesis is advanced according to which thyroxine inhibits the platelet aggregation , interfering with the release of arachidonic acid from phospholipids of platelets ( thrombocytopathy A ) , whereas insulin -- by blocking the cyclooxygenase activity ( thrombocytopathy B ) . - pubmed
Serum lipoproteins of diabetic rats fed a high cholesterol diet . - pubmed
Feeding a diet containing 2 % cholesterol and 1 % cholic acid ( wt / wt ) to rats made diabetic by administration of streptozotocin ( 45 mg / kg ) produced marked hypercholesterolemia characterized by high concentrations of very low density lipoproteins ( VLDL ) and intermediate density lipoproteins ( IDL ) and a reduction in concentration of high density lipoproteins ( HDL ) . - pubmed
[ The renin - aldosterone profile in hypertension ] . - pubmed
Simultaneous study of renin activity and aldosterone concentration in the blood plasma of 180 out - patients with hypertensive disease has shown that persons with normal or increased reninemia predominate in the I stage of disease . - pubmed
In stage II of hypertensive disease renin activity diminishes and the concentration of aldosterone in blood plasma rises , aldosteronerenin index is enhanced at the expense of aldosterone predominance , which is most often seen in the sub - group of patients with low reninemia . - pubmed
Aldosterone - renin index correlates positively with the duration of hypertensive disease . - pubmed
Hypertensive crisis resulting from avocados and a MAO inhibitor . - pubmed
Bcl-2 expression did not inhibit Fas - mediated cytotoxicity triggered by cells expressing FasL or by the transient transfection of human Fas . - pubmed
In contrast , expression of CrmA , a cowpox virus protein that inhibits ICE - like protease activity , blocked activation - induced apoptosis in 2B4 cells but had little effect on Dex - mediated cytotoxicity . - pubmed
Cytotoxic necrotizing factor type 2 ( CNF2 ) produced by Escherichia coli strains isolated from intestinal and extraintestinal infections is a dermonecrotic toxin of 110 kDa . - pubmed
We cloned the CNF2 gene from a large plasmid carried by an Escherichia coli strain isolated from a lamb with septicemia . - pubmed
Gastric inhibitory polypeptide secretion after gastrectomy in patients with diabetes mellitus . - pubmed
Gastric inhibitory polypeptide ( GIP ) secretion after distal gastrectomy was compared between patients with diabetes mellitus ( DM - group ) and patients with normal glucose tolerance ( N - group ) . - pubmed
These findings suggest that GIP secretion in diabetics becomes insufficient after gastrectomy . - pubmed
Cell cycle - dependent expression of TAP1 , TAP2 , and HLA - B27 messenger RNAs in a human breast cancer cell line . - pubmed
TAP-1 and TAP-2 mRNAs were undetectable in quiescent , serum - deprived human breast cancer cells ( 21PT ) . - pubmed
Using conventional riboprobe in situ hybridization , ER transcripts were not detectable in any bone cells within sections taken from normal bone and several actively remodeling bone tissues , namely , Paget ' s disease , renal hyperparathyroidism , and healing fracture callus . - pubmed
Successful engraftment after primary graft failure in aplastic anemia using G - CSF mobilized peripheral stem cell transfusions . - pubmed
A 19 - year - old male underwent allogeneic BMT for severe aplastic anaemia ( SAA ) from his HLA- and blood group - identical sister . - pubmed
Single - cell analysis of intrathyroidal lymphocytes shows differential cytokine expression in Hashimoto ' s and Graves ' disease . - pubmed
However , the larger T lymphocytes , presumably activated and responsible for the autoimmune damage , predominantly produced IL-4 in GD and IFN - gamma in HT . - pubmed
The specificity of the Th2 responses in GD was suggested by the enrichment in IL-4 production after antigen - specific expansion of two oligoclonal T cell lines . - pubmed
It has been proposed that L - selectin and Mac-1 ( CD11b / CD18 ) , two neutrophil adhesion receptors , have sequential roles in neutrophil extravasation during inflammation . - pubmed
Administration of the cytokine interleukin-2 ( IL-2 ) can result in therapeutic benefits for individuals with renal cell carcinoma and melanoma . - pubmed
Here we report an analysis of the transcription factor families AP-1 , Sp1 , NF - kappaB , and signal transducers and activators of transcription ( STAT ) in cancer patients ' lymphocytes before and after IL-2 immunotherapy , as assessed by a gel - shift assay . - pubmed
Increasing plasma neopterin and persistent plasma endothelin during follow - up after acute cerebral ischemia . - pubmed
To evaluate the concentrations of a specific marker for macrophage activation , neopterin , and the potent endothelial derived vasoconstrictive peptide endothelin-1 ( ET-1 ) , during the acute and chronic stages of cerebral ischemia , plasma concentrations of neopterin and ET-1 were measured in 59 patients with acute cerebral infarction or transient ischemic attack ( median age 73 years , range 43 - 93 , 27 men ) and after a 1 - year follow - up in 57/59 ( 97 % ) of patients . - pubmed
Inactivation or mutation in p53 gene is also known to result in loss of control over the cell cycle and increases in tumor proliferation rates . - pubmed
The present study examines the role of HPV infection in relation to p53 and the extent of the tumor proliferative compartment reflected by cyclin D1 and Ki-67 expression during various phases of tumor progression in the oral epithelium . - pubmed
Expression of the tumor suppressor p53 protein also showed significant positive correlation with histology ( r = 0.475 , P = 0.00004 ) . - pubmed
The tumor proliferative fraction also increased with the extent of histological abnormality ( r = 0.387 , P = 0.0003 for cyclin D1 and r = 0.463 , P = 0.0001 for Ki 67 ) . - pubmed
Accumulation of p53 and increase in tumor proliferation also correlated to the presence of HPV infection ( r = 0.511 , P = 0.00003 for p53 ; r = 0.478 , P = 0.00002 for cyclin D1 and r = 0.521 , P = 0.00004 for Ki-67 ) . - pubmed
The partial primary structure of an Mr 24,000 non - haemorrhagic metalloproteinase isolated from the venom of the snake Lachesis stenophrys has been determined . - pubmed
Interestingly , it has almost identical sequence as the metalloproteinase from Lachesis muta muta , LHF - II , which is , however , haemorrhagic . - pubmed
Louse - borne relapsing fever , caused by Borrelia recurrentis , provides one of the best documented examples of the causative role of tumor necrosis factor ( TNF ) in the pathology of severe infection in humans . - pubmed
This review examines the potential pathophysiological involvement of one such developmental gene gremlin in diabetic nephropathy . - pubmed
Immunohistochemically , tumor cells were invariably positive for vimentin and CD99 , and mostly for CD34 but negative for desmin , keratin , CD31 , CD117 ( c - kit ) , and inhibin . - pubmed
About half of the tumors showed reactivity for bcl-2 . - pubmed
Vascular endothelial growth factor ( VEGF ) has a central role in normal as well as in tumor angiogenesis . - pubmed
Like VEGF , the translation of the new isoforms is not sensitive to stress signals such as anoxia . - pubmed
P - selectin is an endothelial cell adhesion glycoprotein expressed on the cell surface early in inflammation where it binds to blood leukocytes . - pubmed
METHODS : Amplification refractory mutation system ( ARMS ) was used to detect beta - thalassaemia , haemoglobin E and sickle cell mutations . - pubmed
Factors associated with progression of IgA nephropathy . - pubmed
Fifty - two ( 30 adults and 22 children ) ( 29.8 % ) complained of mild adverse effects including an increase in aspartate aminotransferase ( & gt;250 IU ) observed in 12 cases and considered related to rifampin and in 11 cases a reversible hyperpigmentation of the tongue attributed to minocycline . - pubmed
HCG tests in the management of gestational trophoblastic diseases . - pubmed
[ HORMONOGENESIS IN ENDEMIC AND SPORADIC GOITERS ] . - pubmed
Thus by using yeast as a model system , we identified the molecular basis of the respiratory defect caused by the disease mutations in cytochrome b. - pubmed
Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients . - pubmed
PATIENTS AND METHODS : We examined the levels of interleukin-6 ( IL-6 ) in the cerebrospinal fluid ( CSF ) of patients with Alzheimer ' s disease ( AD ) ( n = 26 ) , ischemic cerebrovascular disease without dementia ( CVD ) ( n = 11 ) , vascular dementia ( VD ) ( n = 11 ) , and other neurological disorders ( n = 21 ) using sensitive enzyme - linked immunosorbent assay . - pubmed
RESULTS : The CSF concentrations of IL-6 were significantly elevated in patients with VD compared with those of patients with AD or CVD . - pubmed
CONCLUSION : The CSF IL-6 levels are increased in patients with VD , suggesting that inflammatory mechanisms may be involved in the development of cognitive decline in some patients with cerebrovascular disease . - pubmed
CSF IL-6 may be a biological marker for dementia in cerebrovascular disease . - pubmed
Dp71 expression is present in myoblasts but declines during myogenesis to avoid interfering with the function of dystrophin , the predominant Duchenne muscular dystrophy gene product in differentiated muscle fibers . - pubmed
Women with PCOS and the MBS had significantly higher levels of serum free testosterone ( P = 0.002 ) and lower levels of serum SHBG ( P = 0.001 ) than women with PCOS without the MBS . - pubmed
Women with PCOS and the MBS differ from their counterparts lacking the MBS in terms of increased hyperandrogenemia , lower serum SHBG , and higher prevalence of acanthosis nigricans , all features that may reflect more severe insulin resistance . - pubmed
Are polymorphisms of N - acetyltransferase genes susceptible to primary liver cancer in Luoyang , China ? - pubmed
AIM : To identify whether the polymorphisms of the N - acetyltransferase ( NAT ) genes are susceptible to primary liver cancer ( PLC ) in Luoyang , a PLC low - incidence area of China . - pubmed
METHODS : The NAT1 and NAT2 genotypes of 96 PLC cases and 173 controls were determined by PCR - RFLP . - pubmed
[ Expression of glutathione S - transferase isoenzymes in human gliomas ] . - pubmed
The aim of present study was to analyze the expression pattern of GST pi , mu ( mu4 and mu5 ) and alpha at the mRNA and protein levels in human primary gliomas . - pubmed
RESULTS : There were no changes in GST pi mRNA expression , determined by RT - PCR , between gliomas and tumor adjacent tissues . - pubmed
However , using Western blotting method , an increase in GST pi protein in tumors was observed , which might be caused by the lower rate in protein degradation . - pubmed
Decrease in the expression of GST mu at mRNA level ( mu4 ) , as well as at protein level was shown in gliomas compared to control tissues . - pubmed
mRNA for GST mu5 isoform was demonstrated only in two tumor cases , but not in normal tissues , and for GST alpha , in one sample of control tissue . - pubmed
At the protein level , GST pi expression was increased in gliomas , whereas GST mu was decreased . - pubmed
Regulatory role of host CD8 + T lymphocytes in experimental graft - versus - host disease across a single major histocompatibility complex class II incompatibility . - pubmed
We investigated the role of host CD8 + T cells in experimental Th2 - type graft - versus - host disease ( GVHD ) where donor / recipient disparity is restricted to a single major histocompatibility complex ( MHC ) class II antigen . - pubmed
METHODS : Immunoglobulin ( Ig ) E serum levels , eosinophilia and lymphoid tissue hyperplasia were compared after injection of bm12 CD4 + T cells in either wild - type or CD8 + T cell - deficient ( CD8-/- ) C57BL/6 mice . - pubmed
Increased serum levels of IL-5 and IL-13 in CD8-/- hosts confirmed the enhancement of Th2 - type responses in the context of recipient CD8 + T cell deficiency . - pubmed
CONCLUSIONS : Host CD8 + T cells regulate alloreactive Th2 responses during graft - versus - host disease through an IFN - gamma dependent pathway , independently of the recognition of beta2m - associated MHC class I molecules . - pubmed
Pseudohypoparathyroidism ( PHP ) types Ia and Ic result from heterozygous inactivating mutations of Gs alpha , the alpha - subunit of the heterotrimeric stimulatory G - protein , Gs . - pubmed
Collectively , data show alpha - TEA to be a potent apoptotic inducer of both cisplatin - sensitive and -resistant human ovarian cancer cells via activating death receptor Fas signaling and suppressing anti - apoptotic AKT and ERK targets . - pubmed
As a marker for PNEC / NEB we used an antibody against chromogranin A ( CGA ) , and computer - assisted morphometric analysis was employed to determine the relative frequency of PNEC per airway epithelial area ( % immunostained area , % IMS ) , the size of NEB , the number of nuclei / NEB , and the size of the NEB cells . - pubmed
Protection from direct cerebral cryptococcus infection by interferon - gamma - dependent activation of microglial cells . - pubmed
We have recently demonstrated that immunotherapy with anti - CD40 and IL-2 can protect mice against disseminated Cryptococcus infection . - pubmed
These studies indicate that immunotherapy using anti - CD40 and IL-2 can augment host immunity directly in the brain against C. - pubmed
Netrin G1 mutations are an uncommon cause of atypical Rett syndrome with or without epilepsy . - pubmed
Mutations in the methyl - cytosine - phosphate - guanosine dinucleotide ( CpG ) binding protein 2 gene are identified in up to 90 % of patients with classic Rett syndrome . - pubmed
However , the lack of methyl - CpG binding protein 2 mutations in a small group of classic Rett syndrome cases , and the low frequency of these mutations in atypical Rett syndrome patients , suggest that other gene defects may play a role in this disorder . - pubmed
One report described a patient with atypical Rett syndrome who presented with early epilepsy and a de novo translocation which disrupted the Netrin G1 gene . - pubmed
This study tested a sample of 91 female patients with a clinically heterogeneous phenotype ranging from encephalopathy with epilepsy to atypical Rett syndrome without epilepsy for mutations in the Netrin G1 gene , to evaluate its involvement in this condition . - pubmed
Our study suggests that Netrin G1 is not involved in atypical Rett syndrome or in unexplained encephalopathy with epilepsy , but in specific forms to be delineated better in the future . - pubmed
Polymorphisms of the IL1 - receptor antagonist gene ( IL1RN ) are associated with multiple markers of systemic inflammation . - pubmed
CONCLUSIONS : Common functional polymorphisms of the IL1RN gene are associated with several markers of systemic inflammation . - pubmed
Change of cholinergic transmission and memory deficiency induced by injection of beta - amyloid protein into NBM of rats . - pubmed
The impairment of memory after injection of beta - AP(1 - 40 ) into NBM exhibited mainly the deficiency of short - term working memory . - pubmed
The results show that the injection of beta - AP(1 - 40 ) into NBM impairs the cholinergic transmission in frontal cortex , and the impairment of cholinergic transmission may be the main cause of the deficit of working memory . - pubmed
The severity of cholestasis and hepatic injury was determined by changes in the plasma enzyme activities of aspartate aminotransferase , alanine aminotransferase , gama glutamin transferase , and levels of total bilirubin and direct bilirubin . - pubmed
Although one antagonist -- maraviroc , a CCR5 inhibitor to treat AIDS -- has been registered as an approved drug , this is the only success so far . - pubmed
One low molecular weight , weakly active purine template hit was progressed by iterative structure - based design to give submicromolar pyrazolopyridines with good ligand efficiency and appropriate CHK1 - mediated cellular activity in HT29 colon cancer cells . - pubmed
Steroidogenic factor-1 expression in ovarian endometriosis . - pubmed
Steroidogenic factor-1 ( SF-1 ) , a major protein regulating the complex cascade of steroidogenis , has been postulated to play a role in ovarian endometriosis . - pubmed
However , the expression in situ of SF-1 in ovarian endometriosis is unknown . - pubmed
To shed light on its presence , the expression of SF-1 was studied by immunohistochemistry in 30 cases of ovarian endometriosis ( proliferative , n=15 ; secretory phase , n=15 ) and in 10 cases of normal eutopic endometrium coming from the same patients . - pubmed
No SF-1 immunoreactivity was observed in glands or endometrial stroma from ovarian endometriosis or eutopic endometrium . - pubmed
Contrary to the earlier reported hypothesis , our data showed for the first time the absence of SF-1 expression in glands and endometrial stroma from ovarian endometriosis and eutopic endometrium . - pubmed
However , the strong expression of SF-1 observed in cortical and medullary ovarian mesenchymatous cells adjacent to endometriosis , suggests a potential role for these cells in locally induced steroidogenesis . - pubmed
[ Influence of p75 neurotrophin receptor knockout on the regeneration of facial nerves after crush injury in mouse ] . - pubmed
OBJECTIVE : To investigate the role of p75 neurotrophin receptor ( p75NTR ) in the regeneration of facial nerve crush injury . - pubmed
CONCLUSION : p75NTR plays an important role in the regeneration of injured peripheral nerves after injury . - pubmed
The analysis of fungal cells recovered from vaginal fluids of infected animals indicated that c - type was more prone to undergo morphogenesis and to express SAP2 than b - type ; these different traits may account for the differences observed in the outcome of experimental rodent vaginitis induced by the two C. - pubmed
Role of ZNRD1 ( zinc ribbon domain - containing 1 ) in angiogenesis of leukaemia cells . - pubmed
Here , we have first investigated the roles of ZNRD1 in angiogenesis of leukaemia . - pubmed
The leukaemia cell line K562 was transfected with the vector that included the full - length cDNA of ZNRD1 , then the growth and angiogenesis of cells were detected . - pubmed
Up - regulation of ZNRD1 could significantly inhibit the growth of cells , reduce tumour microvessel densities and inhibit the VEGF ( vascular endothelial growth factor ) production . - pubmed
Taken together , ZNRD1 might inhibit tumour angiogenesis and could be considered as a target for leukaemia therapy . - pubmed
Takayasu arteritis : anti - TNF therapy in a Brazilian setting . - pubmed
The aim of this study was to describe clinical features and response to different therapeutic interventions , including anti - tumor necrosis factor ( TNF ) agents , in a case series of Takayasu arteritis ( TA ) from Brazil . - pubmed
Will newer tyrosine kinase inhibitors have an impact in AML ? - pubmed
FLT3 inhibition has been a goal of acute myeloid leukemia ( AML ) therapy since FLT3 mutations were discovered to have a role in AML . - pubmed
Screening by a combination of fetal nuchal translucency and maternal serum free - beta - human chorionic gonadotrophin and pregnancy - associated plasma protein - A can identify about 90 % of fetuses with trisomy 21 and other major aneuploidies for a false - positive rate of 5 % . - pubmed
Induction of ezrin - radixin - moesin molecules after cryogenic traumatic brain injury of the mouse cortex . - pubmed
These results suggest that ERM activation in the injury penumbra is implicated in the inflammatory immune responses after traumatic brain injury . - pubmed
Anti - CD3 and anti - cd16 monoclonal - antibody in - vitro enhancement of NK activity in pbl from gastrointestinal - tract cancer - patients . - pubmed
Enhancement of cellular cytotoxicity by anti - CD3 and anti - CD16 may be of use in cancer immunotherapy protocols . - pubmed
Dried blood spots on filter paper as an alternative specimen for measles diagnostics : detection of measles immunoglobulin M antibody by a commercial enzyme immunoassay . - pubmed
BACKGROUND : We compared the results of a serum - based measles immunoglobulin M ( IgM ) test with results of tests using paired reconstituted dried filter paper blood spot ( DBS ) samples to assess the feasibility of using DBS samples for measles diagnostic procedures . - pubmed
The transcription factor PHR1 ( PHOSPHATE STARVATION RESPONSE 1 ; encoded by gene At4g28610 ) is central for adaptation to phosphate deficiency in Arabidopsis ( Arabidopsis thaliana ) . - pubmed
A rapid turnover of phosphate pools in the leaves is essential for energy transfer and metabolism within photosynthesis , and consequently , we hypothesized that PHR1 is needed for adaptation to high - light stress during P deficiency . - pubmed
We conclude that PHR1 is needed for the metabolic balance , for retaining P(i ) levels and for inducing anthocyanin production , and during P deficiency PHR1 is vital for adaptations to avoid permanent damage to photosystems during high - light conditions . - pubmed
In primary human airway cells with ER stress resulting from cystic fibrosis , D2 activity was absent . - pubmed
This explains the lack of D2 activity in primary human airway cells with ER stress resulting from cystic fibrosis . - pubmed
A temple skin rash , abnormal hepatic function and a remarkable elevated level of serum ferritin occurred later in this patient , which highly supported a potential diagnosis of AOSD . - pubmed
Novel cationic antimicrobial peptide GW - H1 induced caspase - dependent apoptosis of hepatocellular carcinoma cell lines . - pubmed
Two - dimensional gel electrophoresis was applied to further analyze the AMP - responsive protein profiles of HCC , down - regulation of Hsp27 , phophoglycerate kinase 1 and triosephosphate isomerase indicated that GW - H1 may induce apoptosis , and further inhibit progression and metastasis of J5 HCC cells . - pubmed
These findings provided support for future application of GW - H1 as potential therapeutic agent for HCC . - pubmed
Troponin release overestimates infarct size in presence of left ventricular hypertrophy . - pubmed
Systemic inflammation , oxidative stress , elevated serum adipokines and fetuin - A , metabolic acidosis , vitamin D deficiency , depressed serum erythropoietin , endoplasmic reticulum stress , and suppressors of cytokine signaling all cause IR by suppressing insulin receptor - PI3K - Akt pathways in CKD . - pubmed
INTRODUCTION : Ticagrelor , an oral P2Y ( 12 ) receptor antagonist used as part of dual antiplatelet therapy in the treatment of acute coronary syndromes ( ACS ) , has many favorable characteristics when compared with the more frequently used P2Y ( 12 ) receptor antagonist clopidogrel . - pubmed
Kinetic analysis of iron - dependent histone demethylases : alpha - ketoglutarate substrate inhibition and potential relevance to the regulation of histone demethylation in cancer cells . - pubmed
Reported herein is a detailed kinetic analysis of three JmjC - HDMs , including the cancer - relevant JMJD2C , that was achieved by employing three enzyme activity assays . - pubmed
JMJD2C displays an optimal activity in vitro at alphaKG concentrations similar to those found in cancer cells , with implications for the regulation of histone demethylation activity in cancer versus normal cells . - pubmed
BACKGROUND : Dexamethasone is widely used for pulmonary exacerbation in patients with cystic fibrosis , however , not much is known about the effects of glucocorticoids on the wild - type cystic fibrosis channel transmembrane regulator ( CFTR ) . - pubmed
Neuregulin-1 signalling and antipsychotic treatment : potential therapeutic targets in a schizophrenia candidate signalling pathway . - pubmed
Evidence from genetic , transgenic and post - mortem studies have strongly supported neuregulin-1 ( NRG1)-ErbB4 signalling as a schizophrenia susceptibility pathway . - pubmed
NRG1 - ErbB4 signalling plays crucial roles in regulating neurodevelopment and neurotransmission , with implications for the pathophysiology of schizophrenia . - pubmed
Post - mortem studies have demonstrated altered NRG1 - ErbB4 signalling in the brain of schizophrenia patients . - pubmed
Abnormal behaviours relevant to certain features of schizophrenia are displayed in NRG1 / ErbB4 knockout mice or those with NRG1 / ErbB4 over - expression , some of these abnormalities can be improved by antipsychotic treatment . - pubmed
NRG1 - ErbB4 signalling has extensive interactions with the GABAergic , glutamatergic and dopaminergic neurotransmission systems that are involved in the pathophysiology of schizophrenia . - pubmed
Furthermore , the key interaction points between NRG1 - ErbB4 signalling and other schizophrenia susceptibility genes may also potentially provide specific targets for new antipsychotic drugs . - pubmed
Fibulin-1 is down - regulated through promoter hypermethylation and suppresses renal cell carcinoma progression . - pubmed
Fibulin-1 , a multi - functional extracellular matrix protein , is involved in many types of cancer but its function in renal cell carcinoma is unclear . - pubmed
We investigated fibulin-1 expression and function in renal cell carcinoma . - pubmed
MATERIALS AND METHODS : We performed real - time polymerase chain reaction , Western blot analysis and immunohistochemistry to determine fibulin-1 expression in renal cell carcinoma cells and patient tissues . - pubmed
Eukaryotic expression plasmid and a lentiviral vector were used to over express fibulin-1 in ACHN and 786 - O renal cell carcinoma cells to investigate its function in vitro and in vivo . - pubmed
RESULTS : Fibulin-1 was significantly down - regulated in renal cell carcinoma cell lines and patient tissues . - pubmed
Fibulin-1 over expression led dramatically to decreased cell growth , enhanced tumor cell apoptosis , decreased cell motility and angiogenesis in cultured renal cell carcinoma cells and in xenograft tumors in nude mice . - pubmed
CONCLUSIONS : Fibulin-1 is down - regulated in renal cell carcinoma through promoter hypermethylation . - pubmed
Efficacy and safety of NMDA receptor antagonists augmentation therapy for schizophrenia : an updated meta - analysis of randomized placebo - controlled trials . - pubmed
Mutant prolactin receptor and familial hyperprolactinemia . - pubmed
Galactose modified trimethyl chitosan - cysteine ( GTC ) conjugates with various galactose grafting densities were developed for oral delivery of Survivin shRNA - expression pDNA ( iSur - pDNA ) and vascular endothelial growth factor ( VEGF ) siRNA ( siVEGF ) in the synergistic and targeted treatment of hepatoma . - pubmed
In tumor - bearing mice , orally delivered GTC2 NPs could effectively accumulate in the tumor tissues and silence the expression of Survivin and VEGF , evoking increased apoptosis , inhibited angiogenesis , and thus the most efficient tumor regression . - pubmed
Clinicians should consider syncope , lightheadedness , and drop in hemoglobin in absence of rectal bleeding following a colonoscopy as possible warning signs of imminent or emergent splenic injury . - pubmed
SERPINs ( serine protease inhibitors ) are well known as negative regulators of hemostasis , thrombolysis , and innate immune responses . - pubmed
CsSERPIN may take part in regulation of endogenous serine proteinase and CsSERPIN3 may be involved in immune evasion and be a potential candidate for vaccine and drug target for clonorchiasis . - pubmed
CONCLUSIONS : In chronic lymphocytic leukemia , important biomarkers include expression of CD38 and ZAP-70 , IGVH mutational status , somatic mutations in TP53 and NOTCH1 , and abnormalities in chromosomes 11 , 12 , 13q , and 17 . - pubmed
In diffuse large B - cell lymphoma , important biomarkers include chromosomal rearrangement of BCL2 , BCL6 , and MYC and expression of CD5 , BCL2 , and CD43 , as well as somatic mutations in TP53 and BCL6 . - pubmed
Association of functional polymorphisms in interferon regulatory factor 2 ( IRF2 ) with susceptibility to systemic lupus erythematosus : a case - control association study . - pubmed
Previous linkage and association studies in European - American populations suggested genetic role of IRF2 in systemic lupus erythematosus ( SLE ) ; however , this observation has not yet been confirmed . - pubmed
Here we investigated whether IRF2 polymorphisms contribute to susceptibility to SLE in a Japanese population . - pubmed
Association study of 46 IRF2 tag single nucleotide polymorphisms ( SNPs ) detected association of an intronic SNP , rs13146124 , with SLE . - pubmed
In conclusion , our observations supported the association of IRF2 with susceptibility to SLE , and the risk haplotype was suggested to be associated with transcriptional activation of IRF2 . - pubmed
Cleaning up after ICH : the role of Nrf2 in modulating microglia function and hematoma clearance . - pubmed
Using primary microglia to model red blood cell ( main component of hematoma ) clearance , we studied the role of transcription factor nuclear factor - erythroid 2 p45 - related factor 2 ( Nrf2 ) , a master - regulator of antioxidative defense , in the hematoma clearance process . - pubmed
Using autologous blood injection ICH model to measure hematoma resolution , we showed that Nrf2 activator , sulforaphane , injected to animals after the onset of ICH , induced CD36 expression in ICH - affected brain and improved hematoma clearance in rats and wild - type mice , but expectedly not in Nrf2 knockout ( KO ) mice . - pubmed
Normal hematoma clearance was impaired in Nrf2 - KO mice . - pubmed
Our experiments suggest that Nrf2 in microglia play an important role in augmenting the antioxidative capacity , phagocytosis , and hematoma clearance after ICH . - pubmed
Insulin - like Growth Factor-1 ( IGF-1 ): Demographic , Clinical and Laboratory Data in 120 Consecutive Adult Patients with Thalassaemia Major . - pubmed
The aim of this study was to measure IGF-1 values and other clinical data in a large number of adult patients with TM to evaluate the possible relationships between them . - pubmed
PATIENTS AND METHODS : A cohort of 120 adult patients with TM was studied for plasma levels of IGF-1 . - pubmed
In these patients endocrine complications and elevations of aminotransferases ( ALT ) were more common compared to TM patients with IGF1 & gt ; -2SDs . - pubmed
AGHD was diagnosed in 6 ( 4 males ) out of 11 patients ( 54.5 % ) who had glucagon stimulation tests and in 5 out of 8 ( 62.5 % ) with IGF-1 & lt;-2SD . - pubmed
CONCLUSIONS : In 50 % of TM patients the IGF-1 levels were 2SDs below average values for healthy individuals . - pubmed
IGF-1 deficiency was more common in TM patients with associated endocrine complications , and a significant correlation was found in HCV - RNA positive females among IGF-1 , ALT , and serum ferritin . - pubmed
Further data in a larger group of patients are needed to confirm whether IGF-1 level & lt;-2 SDs may be a potential criterion for additional studies in TM patients . - pubmed
A p7 Ion Channel - derived Peptide Inhibits Hepatitis C Virus Infection in Vitro . - pubmed
As compared with SCI group and sham control it was observed that Angelica Sinensis significantly reduced the expression of I - kBalpha and NF - kB p65 , ( P<0.05 ) , while MPO activity was also significantly reduced . - pubmed
Clinical Validation of a Novel Commercial Reverse Transcription - Quantitative Polymerase Chain Reaction Screening Assay for Detection of ALK Translocations and Amplifications in Non - Small Cell Lung Carcinomas . - pubmed
CONTEXT : -EGFR mutations and anaplastic lymphoma kinase ( ALK ) translocations have significant biologic and therapeutic implications in lung cancers , particularly lung adenocarcinomas . - pubmed
The 2013 College of American Pathologists / Association for Molecular Pathology / International Association for the Study of Lung Cancer molecular testing guideline for lung cancers recommend a testing algorithm in which detection of ALK translocations using fluorescence in situ hybridization ( FISH ) is to be performed following testing for EGFR mutations . - pubmed
RESULTS : -We performed a retrospective review of cases previously tested by FISH and found that all FISH ALK translocation - positive specimens were RT - qPCR positive , and all FISH ALK translocation - negative cases were RT - qPCR negative ( the sensitivity and specificity of the ALK RT - qPCR assay were 100 % ) . - pubmed
CONCLUSION : -This assay allows rapid identification of ALK alterations , can be performed in conjunction with EGFR testing , and does not require use of valuable additional tumor tissue . - pubmed
Decreased expression of mucin 18 is associated with unfavorable postoperative prognosis in patients with clear cell renal cell carcinoma . - pubmed
BACKGROUND : MUC18 is correlated with tumor progression and metastasis in types of malignancy . - pubmed
But the role of MUC18 in clear cell renal cell carcinoma remains unclear . - pubmed
In this study , we aimed to investigate the expression of MUC18 and its correlation with clinical outcomes in clear cell renal cell carcinoma . - pubmed
RESULTS : MUC18 expression was significantly decreased in tumor compared to non - tumor tissue ( P<0.001 ) . - pubmed
Lower MUC18 expression in tumor predicted a shorter survival time ( P=0.007 ) . - pubmed
CONCLUSION : MUC18 is an independent prognostic factor for clear cell renal cell carcinoma and could be incorporated with the other parameters to predict 5- and 8 - year overall survival for clear cell renal cell carcinoma patients . - pubmed
In HEK293 cells , miR-153 - 3p and miR-205 - 5p down - regulate alpha - synuclein ( SNCA ) and Leucine - rich repeat kinase 2 ( LRRK2 ) , two key proteins involved in Parkinson ' s disease ( PD ) . - pubmed
Many of the differentially expressed proteins are involved in diverse pathways including metabolism , neurotrophin signaling , actin cytoskeletal regulation , HIF-1 signaling and the proteasome indicating that miR-153 - 3p and miR-205 - 5p are involved in the regulation of a wide variety of biological processes in neuroblastoma cells . - pubmed
Peak height thrombin levels showed a decrease over time in all tumor types . - pubmed
Patients who developed VTE ( n = 14 ) showed increasing levels of FVIII , sP - selectin , and D - dimer . - pubmed
The author has reviewed the updated data of genetic aspects of bAVMs , especially focusing on clinical and experimental knowledge from hereditary hemorrhagic telangiectasia , which is the representative genetic disease presenting with bAVMs caused by loss - of - function in one of the two genes : endoglin and activin receptor - like kinase 1 . - pubmed
Whole exome sequencing identifies a homozygous POLG2 missense variant in an infant with fulminant hepatic failure and mitochondrial DNA depletion . - pubmed
Heterozygous mutations in POLG2 were previously associated with progressive external ophthalmoplegia and mtDNA deletions . - pubmed
This is the first report of a patient with a homozygous mutation in POLG2 and with a clinical presentation of severe hepatic failure and mitochondrial depletion . - pubmed
Because of the small number of patients with partial trisomy 21 , we addressed the question in the Mouse in which three chromosomal regions located on MMU10 , MMU17 and MMU16 carries almost all the HSA21 homologs . - pubmed
Histopathology of tissue in reticulin - stained slide showed the presence of immature muscle fibers whereas Masson 's trichrome stain revealed collagen fibers and smooth muscles confirming the diagnosis of oral midline subcutaneous smooth muscle ( leiomyomatous ) hamartoma of incisive papilla . - pubmed
Hydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogen - activated protein kinase - caspase-3 signaling pathway following cerebral ischemia - reperfusion injury . - pubmed
In the present study , we measured the levels of secreted cytokines by effect or T cells in TCE - treated guinea pigs to better understand the contribution of allergic disorders in renal injuries . - pubmed
Beyond Human Leukocyte Antigen Class I Antigens : Hereditary Hemochromatosis Gene Mutations in Recurrent Aphthous Oral Ulcers and Behcet Disease in the South of Tunisia . - pubmed
OBJECTIVE : The aim of this work was to establish human leukocyte antigen ( HLA ) class I and hereditary hemochromatosis gene ( HFE ) mutation associations with recurrent aphthous oral ulcers ( RAOU ) and Behcet disease ( BD ) in a cohort of Southern Tunisian patients . - pubmed
RESULTS : HLA - B51 was positively associated with BD , particularly in those with severe manifestations . - pubmed
No association was detected with HLA class I polymorphism among the BD group . - pubmed
Based on stratification to clinical manifestations , the isolated RAOU was negatively associated with HLA - A1 with a difference close to significance ( 12 [ 14.81 % ] vs. 32 [ 26.02 % ] in HCs ; p = 0.06 ) . - pubmed
Considering HFE mutations , patients with isolated RAOU had a higher frequency of H63D when compared with other subgroups , especially after limiting the comparison to 27 patients of at least 5 years of follow - up . - pubmed
CONCLUSION : This study showed that , unlike BD , RAOU were not associated with HLA - B51 . - pubmed
RESULTS : Independent predictors of L-2 - ALNM by the multivariate logistic regression analysis included tumor size , Ki-67 status , histological grade , and number of positive level 1 axillary lymph nodes . - pubmed
IgG4 - related disease ( IgG4 - RD ) is an inflammatory condition characterized by a high serum IgG4 concentration and the abundant infiltration of lymphocytes and IgG4 - positive plasma cells in the tissue , as well as spatial ( diverse clinical manifestations ) and temporal ( the possibility of recurrence ) multiplicities . - pubmed
Considering that IgG4 - RD was specified as being an intractable disease in 2015 , further studies are needed to clarify whether IgG4 - RD is indeed a distinct disease entity or a complex of disorders of different etiologies and clinical conditions . - pubmed
The expression levels of genes involved in inflammatory signaling ( TNFAIP2 , ACOT7 , and RORA ) were also associated with birth weight , suggesting a role for inflammatory processes in Cd - associated reproductive toxicity . - pubmed
Kinesin Spindle Protein ( KSP ) or Eg5 is an essential kinesin that is involved in spindle separation process during mitosis and also unregulated in certain cancer cells . - pubmed
RESULTS : CD4+TCM , CD4+TEM , CD8+TCM levels and CD4+/CD8 + TEM of NSCLC patients were significantly lower than those of the control group , while CD4+/CD8 + TCM was significantly higher than that of the control group(all P<0.05 ) . - pubmed
In NSCLC patients , CD4+TCM , CD4+TEM and CD8+TCM were decreased and CD8+TEM levels were increased 4 weeks after radiotherapy(all P<0.05 ) ; CD4+TCM , CD4+TEM and CD8+TCM at 12 - week after radiotherapy were increased significantly compared with those at 4 - week after radiotherapy(all P<0.05 ) . - pubmed
The short ( S ) allele of a functional polymorphism ( 5 - HTTLPR ) within the promoter region of the serotonin transporter gene ( SLC6A4 ) is found to predispose the risk for stress - related affective disorders relative to the long ( L ) allele . - pubmed
P16INK4a gene promoter methylation as a biomarker for the diagnosis of non - small cell lung cancer : An updated meta - analysis . - pubmed
BACKGROUND : This meta - analysis was conducted to investigate the diagnostic performance of P16INK4a gene promoter methylation as a biomarker of non - small cell lung cancer ( NSCLC ) . - pubmed
The pooled sensitivity , specificity , positive and negative likelihood ratios , and diagnostic odds ratio were 0.46 ( 95 % confidence interval [ CI ] 0.43 - 0.48 ) , 0.90 ( 95 % CI 0.88 - 0.91 ) , 6.33 ( 95 % CI 3.89 - 10.30 ) , 0.57 ( 95 % CI 0.50 - 0.65 ) and 10.72 ( 95 % CI 6.94 - 16.56 ) , respectively , for P16INK4a gene promoter methylation as a biomarker for the diagnosis of NSCLC . - pubmed
CONCLUSION : P16INK4a gene promoter methylation detection in serum or bronchoalveolar fluid / sputum may be a potential biomarker for NSCLC diagnosis ; however , the sensitivity was relatively low , which is not suitable for NSCLC screening . - pubmed
We focused on one potential anti - HCMV target , MAPK4 K , and identified lead compounds inhibiting MAP4K4 that have anti - HCMV activity with little cellular cytotoxicity . - pubmed
Chemical immunosuppressive drugs including mammalian target of rapamycin inhibitors ( sirolimus and everolimus ) , calcineurin inhibitors ( tacrolimus and cyclosporine ) , and purine and pyrimidine synthesis inhibitors ( 6 - mercaptopurine , mycophenolic acid , and methotrexate ) are widely prescribed for the treatment of autoimmune and inflammatory diseases and for controlling alloimmunity in interfering with the signals that activate and allow T cells to proliferate . - pubmed
Royal Jelly Alleviates Cognitive Deficits and beta - Amyloid Accumulation in APP / PS1 Mouse Model Via Activation of the cAMP / PKA / CREB / BDNF Pathway and Inhibition of Neuronal Apoptosis . - pubmed
Alzheimer ' s disease ( AD ) is characterized clinically by progressive cognitive decline and pathologically by the accumulation of amyloid - beta ( Abeta ) in the brain . - pubmed
Importantly , hippocampal cyclic adenosine monophosphate ( cAMP ) , p - PKA , p - CREB and BDNF levels were significantly increased in the APP / PS1 mice after RJ treatment , indicating that the cAMP / PKA / CREB / BDNF pathway might be related to the ameliorative effect of RJ on cognitive decline . - pubmed
Repeated measures linear regression models estimated the anemia - type associated change in the CD4 cell - count , QOL , body mass index ( BMI ) and frailty over 18 months . - pubmed
Cox proportional hazard models estimated associations between anemia - type and time to ( a ) gain at least 100 CD4 cells / L and ( b ) hospitalization / death . - pubmed
ACD incidence decreased by 53 % ( 95%CI : 0.27 - 0.79 ) per 100 cells / L increase in baseline CD4 - cell count and decreased by 90 % ( 95%CI : 0.01,0.87 ) among adults treated with nevirapine - containing HAART . - pubmed
Macrocytic anemia did not predict a post - enrollment change in CD4 , BMI or QOL during follow - up . - pubmed
Glucose Oxidase - Based Glucose - Sensitive Drug Delivery for Diabetes Treatment . - pubmed
The glucose - sensitive drug delivery systems based on glucose oxidase ( GOD ) , which exhibit highly promising applications in diabetes therapy , have attracted much more interest in recent years . - pubmed
METHODS : Cytokine evaluation was performed via multiplex cytokine array for 65 immune markers in plasma during the different phases of hepatitis . - pubmed
During the phase of detectable HEV RNA in serum , there was a surge in T - cell - related immune mediators , as well as interferon alpha and interferon gamma - induced protein 10 ( IP-10 ) , characteristic of a viral infection . - pubmed
After clearance of the virus in the blood and development of cholestatic hepatitis , several inflammatory markers subsided , followed by an increase in immune factors related to anti - inflammatory activity , as well as monocyte / macrophage - related markers , likely due to the intrahepatic presence of the virus . - pubmed
Tissue and Plasma EGFR Mutation Analysis in the FLAURA Trial : Osimertinib vs Comparator EGFR - TKI as First - Line Treatment in Patients with EGFR Mutated Advanced NSCLC . - pubmed
PURPOSE : To assess the utility of the cobas EGFR Mutation Test , with tissue and plasma , for first - line osimertinib therapy for patients with EGFR - mutated ( EGFRm ) ( Ex19del and/or L858R ) advanced or metastatic non - small cell lung cancer ( NSCLC ) from the FLAURA study ( NCT02296125 ) . - pubmed
EXPERIMENTAL DESIGN : Tumor tissue EGFRm status was determined at screening using the central cobas tissue test or a local tissue test . - pubmed
Baseline circulating tumor ( ct)DNA EGFRm status was retrospectively determined with the central cobas plasma test . - pubmed
Lack of EGFRm detection in plasma was associated with prolonged PFS vs patients plasma EGFRm positive , potentially due to patients having lower tumor burden . - pubmed
In 25 cases molecular analysis was performed showing alterations in 21 patients : 6 cases with AML / ETO , 3 PML / RAR , 7 Flt3 mutations ( 2 associated with NPM1 mutation ) as well as 1 case of isolated mutation of NPM1 and respectively WT1 . - pubmed
PARP Inhibitors for Ovarian Cancer : Current Indications , Future Combinations , and Novel Assets in Development to Target DNA Damage Repair . - pubmed
PARP inhibitors ( PARPIs ) have revolutionized the treatment of epithelial ovarian cancer , first for BRCA - associated cancer , and , recently , for all epithelial cancers of serous or high - grade endometrioid subtypes in the front line . - pubmed
BACKGROUND & AIMS : The I148 M variant in PNPLA3 is the major genetic risk factor for non - alcoholic fatty liver disease ( NAFLD ) . - pubmed
Gene expression data indicate that PNPLA3 is liver - specific in humans , but whether it functions in adipose tissue ( AT ) is unknown . - pubmed
We investigated whether PNPLA3 - I148 M modifies AT metabolism in human NAFLD . - pubmed
RESULTS : PUFA - TGs were significantly increased in AT in carriers versus non - carriers of PNPLA3 - I148M. - pubmed
PNPLA3 mRNA was 33 - fold higher in the liver than in AT ( p<0.0001 ) . - pubmed
In contrast , PNPLA3 protein levels per tissue protein were 3 - fold higher in AT than the liver ( p<0.0001 ) and 9 - fold higher when related to whole - body AT and liver tissue masses ( p<0.0001 ) . - pubmed
CONCLUSIONS : Contrary to previous assumptions , PNPLA3 is highly abundant in AT . - pubmed
Changes in AT metabolism do not contribute to NAFLD in PNPLA3 - I148 M carriers . - pubmed
Elevated parathyroid hormone ( PTH ) concentrations were reported to be associated with chronic renal allograft failure . - pubmed
In CKD patients , the majority of the circulating PTH is oxidized . - pubmed
Targeting Pharmacokinetic Drug Resistance in Acute Myeloid Leukemia Cells with CDK4 / 6 Inhibitors . - pubmed
The therapy outcomes are often compromised by the existence of a resistant AML phenotype associated with overexpression of ABCB1 and ABCG2 transporters . - pubmed
In this study , we investigated the modulatory potential of the CDK4 / 6 inhibitors abemaciclib , palbociclib , and ribociclib on AML resistance using peripheral blood mononuclear cells ( PBMC ) isolated from patients with de novo diagnosed AML . - pubmed
We first confirmed inhibitory effect of the tested drugs on ABCB1 and ABCG2 in ABC transporter - expressing resistant HL-60 cells while also showing the ability to sensitize the cells to cytotoxic drugs even as no effect on AML - relevant CRE isoforms was observed . - pubmed
Expansion of the GAA / TTC repeats in the first intron of the FXN gene causes Friedreich ' s ataxia . - pubmed
One of the latter ( rs13266634 ) locates in a SLC30A8 exon , encoding a tryptophan - to - arginine substitution that decreases SLC30A8 function , being the canonical explanation for type 2 diabetes risk association . - pubmed
However , other type 2 diabetes associated SNPs that truncate SLC30A8 , confer protection to this disease , contradicting this explanation . - pubmed
Analysis of rostral ventrolateral medulla gene expression confirmed the presence of ERS , inflammation , and activation of renin - angiotensin system pathways in high output HF and showed that TUDCA treatment completely abolished ERS and ERS - related signaling . - pubmed
Exploiting the pro - resolving actions of glucocorticoid - induced proteins Annexin A1 and GILZ in infectious diseases . - pubmed
Although the role of GILZ and AnxA1 in the context of infectious diseases remain to be better explored , herein we provide an overview of the emerging functions of these GC - proteins obtained from pre - clinical models of infectious diseases . - pubmed
PURPOSE : Diagnosis of prostate cancer ( CaP ) is based on digital rectal examination ( DRE ) and/or elevated prostate specific antigen ( PSA ) level . - pubmed
Response to comments on : Short - term outcome of botulinum neurotoxin A injection with or without sodium hyaluronate in the treatment of infantile esotropia - A prospective interventional study . - pubmed
Regulation of valproic acid induced EMT by AKT / GSK3beta / beta - catenin signaling pathway in triple negative breast cancer . - pubmed
Valproic acid ( VPA ) is a selective histone deacetylation ( HDAC ) inhibitor and exerts anti - cancer properties in different types of cancer . - pubmed
Therefore , we aimed to clarified the unravel relationship between AKT / GSK3beta / beta - catenin signalling pathway and VPA - induced EMT in triple negative breast cancer ( TNBC ) . - pubmed
Additionally , Annexin V , cell cycle and wound healing assays were performed . - pubmed
Patients achieving SVR showed a significant decrease in the mean serum alanine transaminase ( ALT ) levels ( 50.90 + -54.60 U / L to 17.00 + -14.50 U / L ) and model for end - stage liver disease ( MELD ) scores ( 7.51 + -4.54 to 7.32 + -3.40 ) ( p<0.05 ) . - pubmed
The most common adverse events were fatigue ( 12.6 % ) , pruritis ( 7.3 % ) , increased serum ALT ( 4.7 % ) and bilirubin ( 3.8 % ) levels , and anemia ( 3.1 % ) . - pubmed
The activation of Hageman factor , followed by complement cleavage leading to liberation of various chemical mediators , can be initiated by exposure of negatively charged tissue components due to trauma and infection . - pubmed
The latter caused almost no change or a slight increase in serum lipid levels with a decrease in pre beta - lipoprotein and an increase in alpha - lipoprotein , though it was not found in MAP . - pubmed
Acute toxicity and pharmacology of beta - human chorionic gonadotrophin conjugated tetanus toxoid ( Pr - beta - HCG - TT ) . - pubmed
A mammary cell - specific enhancer in mouse mammary tumor virus DNA is composed of multiple regulatory elements including binding sites for CTF / NFI and a novel transcription factor , mammary cell - activating factor . - pubmed
The most important 9 parameters were scored according to the prognostic value as follows : age , proportion of blasts in bone marrow , blast count in peripheral blood , morphological subtype , percentage of granulocytes in bone marrow , proportion of blasts with CD-15 antigen , thrombocyte count , spleen / liver enlargement , protein concentration in cerebro - spinal fluid . - pubmed
Reduction of inflammation , tissue damage , and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion - promoting receptors of leukocytes . - pubmed
Intravenous injection of the anti - CD18 mAb IB4 effectively blocked the development of leukocytosis in the CSF of animals challenged intracisternally with living bacteria , bacterial endotoxin , or bacterial cell wall . - pubmed
This effect was associated with protection from blood brain barrier injury as measured by exclusion of serum proteins from CSF in mAb - treated animals . - pubmed
Therapy with mAb IB4 prevented development of brain edema and death in animals challenged with lethal doses of Streptococcus pneumoniae . - pubmed
These studies indicate that the major mechanism of leukocyte migration across the blood brain barrier involves the CD11 / CD18 receptors and that inflammatory leukocytes recruited by this mechanism are a major cause of blood brain barrier injury and cerebral edema during meningitis . - pubmed
Disposable insulin syringes and drug abuse . - pubmed
Low activity of angiotensin converting enzyme ( ACE ) has been reported in patients with smoking related diseases , such as chronic bronchitis , emphysaema and carcinoma of the lung [ 1 ] but this has not been reported in healthy , chronic smokers . - pubmed
The level of fructose 2,6 - bisphosphate , a regulator of phosphofructokinase activity , is decreased by 20 % in the alloxan diabetic rat heart , this may be a significant additional factor in the marked decrease in the flux of glucose through the glycolytic route in the myocardium in diabetes . - pubmed
The measurement of plasma levels of human follicle - stimulating hormone ( FSH ) has proved to be of value for the study of the hypothalamic - hypophyseal - gonadal axis , greatly facilitating the diagnosis and mangement of problems relating to the menopause and infertility . - pubmed
To examine the relationship between the immune responses to hydralazine , a drug known to induce systemic lupus erythematosus , and to deoxyribonucleoprotein ( DNP ) we followed prospectively 21 hypertensive patients treated with hydralazine for the first time . - pubmed
In one patient whose serum had a positive antinuclear antibody test prior to treatment , a mild hydralazine systemic lupus erythematosus syndrome developed preceded by rises in the levels of both anti - hydralazine and anti - DNP . - pubmed
Studies by radioimmunoassay on serums of three additional patients , not followed in this study but known to have hydralazine - induced systemic lupus erythematosus , revealed no evidence for either ( 1 ) cross - reactivity between anti - DNP and anti - hydralazine or ( 2 ) antibodies specific for a hydralazine - DNP complex . - pubmed
Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma ( BCIE ) . - pubmed
Insulin - like growth factor - binding protein-3 production by MCF-7 breast cancer cells : stimulation by retinoic acid and cyclic adenosine monophosphate and differential effects of estradiol . - pubmed
The insulin - like growth factors ( IGFs ) stimulate the proliferation of human breast cancer cells , including the estrogen - dependent cell line MCF-7 . - pubmed
These data demonstrate that modulating the production of IGFBPs can lead to changes in the sensitivity of breast cancer cells to IGFs , and as a result change the cell proliferative effects of these growth factors . - pubmed
Dissecting the roles of the individual IGFBPs is essential to understanding how such differential regulation will ultimately affect IGF - stimulated cell proliferation in breast cancer . - pubmed
Specific IgE were found most often in patients with AD . - pubmed
Immunohistochemical evaluation of tenascin in benign eccrine gland tumors : comparison with laminin and fibronectin . - pubmed
Surgically resected specimens of skin appendage tumors , spiradenoma , poroma of eccrine glands , syringoadenoma , syringoadenoma papilliferum and mixec tumor of skin were evaluated for tenascin , as well as the basement membrane - associated protein laminin , and the extracellular matrix protein fibronectin , using immunohistochemical methods . - pubmed
Tenascin in syringoadenoma was also expressed linearly adjacent to the basement membrane . - pubmed
Mixed tumors of skin showed a characteristic distribution of tenascin in the modified myoepithelial cell area adjacent to the tumor epithelia with a heterogeneous pattern , and particularly strong expression in the hyalinous and chondroid areas . - pubmed
In addition , the localization of laminin in the basement membranes of tumors , intracellular immunoreactivity was observed in syringoadenoma , syringocystadenoma papilliferum , and mixed tumor of skin . - pubmed
Fibronectin reactivity was visualized as a diffuse staining in the tumor stroma of eccrine poroma but its expression was restricted in eccrine spiradenoma . - pubmed
Tn and sialyl - Tn carbohydrate structures , first identified in glycophorins of persons with the rare Tn syndrome , were found to be present on the surface of most cancer cells . - pubmed
In this article , the studies on Tn and sialyl - Tn antigens as diagnostic and prognostic tumor markers and as immunogens in vaccines for cancer immunotherapy are shortly reviewed . - pubmed
Prompt institution of corticosteroid treatment is regarded as indispensable at increase of CRP / S - AA due to infection or surgery . - pubmed
PATIENTS AND METHODS : Twenty - two consecutive patients with severe anemia ( hemoglobin & lt ; 5 g / dl ) of gradual onset requiring transfusion of packed red blood cells ( PRBC ) were studied . - pubmed
A mouse ( BWTG3 ) and a rat ( 7777 ) hepatoma , both of which exhibit characteristics of fetal hepatocytes , were found to contain LPL mRNA , whereas the more differentiated human ( Hep G2 and Hep 3B ) or rat ( Fa32 ) hepatoma cell lines did not . - pubmed
Somatic cell hybrids between LPL - producing hepatoma cells and non - LPL - producing cells , such as adult rat hepatocytes or fibroblasts , exhibited extinction of LPL gene expression . - pubmed
Intrathecal administration of recombinant human superoxide dismutase 1 in amyotrophic lateral sclerosis : a preliminary safety and pharmacokinetic study . - pubmed
Two of the 16 subjects had familial ALS and mutations in the gene for Cu / Zn SOD1 . - pubmed
A few previous studies have described intrinsic MRP expression in both NSCLC and normal lung tissues . - pubmed
Using 15 unselected cell lines , we show that MRP ( mRNA and protein as detected by reverse transcriptase polymerase chain reaction and immunoblot ) is frequently expressed intrinsically , with markedly varying intensity , in NSCLC . - pubmed
MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups . - pubmed
Expression of osteopontin in Meckel ' s cartilage cells during phenotypic transdifferentiation in vitro , as detected by in situ hybridization and immunocytochemical analysis . - pubmed
Therefore , the soluble suppressing activity of CD8 + cells in HIV-2 - infected baboons may be analogous to the CD8 + cell antiviral factor described in human HIV - infected asymptomatic people . - pubmed
Association of plasma lipids and apolipoproteins with the insulin response element in the apoC - III promoter region in familial combined hyperlipidemia . - pubmed
The apoAI - CIII - AIV gene cluster , located on chromosome 11 , contributes to the phenotype of familial combined hyperlipidemia ( FCH ) , but this contribution is genetically complex . - pubmed
Combinations of haplotypes , based on three restriction enzyme polymorphisms : XmnI and MspI sites , 5 ' of the start site of the apoA - I gene and SstI polymorphism in the 3 ' untranslated region of exon 4 of the apoC - III gene , were analyzed to characterize their effect on the expression of severe hyperlipidemia . - pubmed
In the present study two additional polymorphic sites in the insulin response element ( IRE ) of the apoC - III gene promoter , T-455C : FokI restriction site , C-482 T : MspI restriction site , were studied in 34 FCH pedigrees including 34 probands , 220 hyperlipidemic relatives , 300 normolipidemic relatives , and 236 spouses . - pubmed
Analysis of combinations of haplotypes based on the five polymorphisms in the gene cluster provided further evidence for a dominant role of the SstI polymorphism as a major susceptibility locus in FCH . - pubmed
BACKGROUND : Cytokines mediate the metabolic and physiologic responses to injury and infection . - pubmed
CONCLUSION : Stimulation of pituicytes by TNF or IL-1 induces the release of HMG-1 , which may participate in the regulation of neuroendocrine and immune responses to infection or injury . - pubmed
[ Changes in synthesis of nitric oxide , blood levels of ACTH and cortisol in viral hepatitis B ] . - pubmed
A negative correlation between nitrituria / nitraturia and ALAT , ASAT , bilirubin , alkaline phosphatase , gamma - glutamyl - transpeptidase is an indirect evidence for a protective role of NO against viral hepatitis B. - pubmed
The influence of pertussis toxin , a decisive virulence factor in the pathogenesis of pertussis disease , on barrier integrity was investigated in model systems for blood - liquor ( epithelial ) and blood - brain ( endothelial ) barriers . - pubmed
A recent study implicating the common stress mediator NF - kappaB in glaucoma would support this notion . - pubmed
Clinical observations on allergic sensitivity to insulin . - pubmed
GENERAL DEVELOPMENT AND PROGNOSTIC ELEMENTS OF CIRRHOSIS ] . - pubmed
[ TREATMENT OF CORONARY CIRCULATORY DISORDERS WITH ISOPTIN IN GENERAL PRACTICE ] . - pubmed
Lifestyle changes as recommended in diabetes are fundamental for treatment ; addition of insulin - sensitising agents ( eg , metformin ) may be valuable in circumstances such as anovulatory infertility . - pubmed
Infertility can be treated successfully in most women by diet and exercise , clomiphene citrate with or without metformin , ovarian drilling , or ovulation induction with gonadotrophins ; in - vitro fertilisation should be avoided unless there are other indications . - pubmed
Peri - sciatic proinflammatory cytokines , reactive oxygen species , and complement induce mirror - image neuropathic pain in rats . - pubmed
Peri - sciatic injection of selective inhibitors / antagonists revealed that a number of immune products are early mediators of the resultant allodynias , including proinflammatory cytokines ( tumor necrosis factor , interleukin-1 , and interleukin-6 ) , ROS , and complement . - pubmed
[ A new treatment of keratectasia after LASIK by using collagen with riboflavin / UVA light cross - linking ] . - pubmed
RESULTS : Due to the induced collagen cross - linking the biomechanical status of the cornea was stabilized and a progression of the keratectasia was prevented . - pubmed
The genotypes without Px haplotype might exert some favorable effect on BMD , while those with Px haplotype may be harmful to bone - pubmed
A motor neuron disease - associated mutation in p150Glued perturbs dynactin function and induces protein aggregation . - pubmed
B - type natriuretic peptide testing is an attractive and non - invasive tool in non - surgical patients for the diagnosis of heart failure , but its role in the perioperative period for the diagnosis of myocardial contractile dysfunction is less clear . - pubmed
For verification of a diagnosis of cancer , high - molecular - weight cytokeratin was still the most commonly used immunohistochemical marker ( 91 % ) , followed by p63 ( 58 % ) and alpha - methylacyl - CoA - racemase ( 50 % ) . - pubmed
This may have relevance , for instance , to cancer , as HIF-1 overexpression is observed in many human cancers and has been associated with increased patient mortality . - pubmed
Experimental studies have suggested that angiotensin converting enzyme inhibitors and calcium channel blockers may prevent or arrest progression of renal injury . - pubmed
Prostate - specific antigen doubling time is increasingly used as an indicator of disease recurrence after local therapy and prostate cancer - specific survival . - pubmed
BACKGROUND : The positron emission tomography ( PET ) with F18 17beta - estradiol ( FES ) has good imaging for assessment of estrogen receptor in breast cancer . - pubmed
Oxygen sensing and redox signaling : the role of thioredoxin in embryonic development and cardiac diseases . - pubmed
Here we discuss the roles of TRX on oxygen stress and redox regulation from different perspectives , in embryogenesis and in adult diseases focusing on cardiac disorders . - pubmed
Based on the ability of NLAs to bind strongly to DNA through intercalation , we investigated whether their relatively high aerobic cytotoxicity and their relatively low hypoxic selectivity in vitro are associated with topoisomerases I and II ( Topo I and II ) inhibition . - pubmed
These results suggest that topoisomerase inhibition accounts for NLAs aerobic toxicity . - pubmed
Significant association of DRD1 with nicotine dependence . - pubmed
In this study , we examined five single - nucleotide polymorphisms ( SNPs ) within or near the dopamine D ( 1 ) receptor gene ( DRD1 ) for their association with ND , which was assessed by smoking quantity ( SQ ) , the Heaviness of Smoking Index ( HSI ) , and the Fagerstrom Test for ND ( FTND ) . - pubmed
One isoform of alpha1 - antitrypsin showed decreased glycosylation in AD patients while another glycosylated isoform of an unassigned protein was up - regulated . - pubmed
Protein expression levels of alpha1 - antitrypsin were decreased , while the protein levels of apolipoprotein E and clusterin were increased in AD . - pubmed
Pivotal role of angiotensin II receptor subtype 1A in the development of two - kidney , one - clip hypertension : study in angiotensin II receptor subtype 1A knockout mice . - pubmed
OBJECTIVE : The present study was performed to examine in two - kidney , one - clip ( 2K1C ) Goldblatt hypertensive mice : first , the relative contribution of angiotensin II receptor subtypes 1A ( AT ( 1A ) ) and 1B ( AT ( 1B ) ) ; second , the role of angiotensin II type 2 ( AT ( 2 ) ) receptors in the development of hypertension in wild - type ( AT(1A)+/+ ) and AT ( 1A ) receptor knockout ( AT(1A)-/- ) mice ; and third , the role of increased nitric oxide synthase activity in counteracting the hypertensinogenic action of angiotensin II in this model . - pubmed
CONCLUSION : The present data support the critical role of AT ( 1A ) receptors in the development of 2K1C hypertension , whereas AT ( 1B ) receptors play only a minor role in blood pressure regulation in this model of angiotensin II - dependent hypertension . - pubmed
Activation of AT ( 2 ) receptors does not play an antagonistic role in the AT ( 1 ) receptor - mediated hypertensinogenic actions of angiotensin II in this model . - pubmed
Finally , enhanced nitric oxide synthase activity plays a protective role by counteracting the vasoconstrictor influences of angiotensin II in 2K1C hypertensive mice . - pubmed
BACKGROUND AND PURPOSE : Superoxide ( O ( 2 )(*- ) ) , derived from nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase , is associated with acute respiratory distress syndrome ( ARDS ) . - pubmed
ACS6 may be effective in treating ARDS through both elevation of cAMP and inhibition of phosphodiesterase type 5 activity . - pubmed
METHODS : Fos immunoreactivity revealing neuronal activation , and degenerating neurons labeled by Fluoro - Jade B ( FJB ) histochemistry were analyzed on the first day after onset of seizures lasting 3 h. Subpopulations of gamma - aminobutyric acid ( GABA)ergic cells were characterized with double Fos - parvalbumin immunohistochemistry . - pubmed
In Proechimys , almost all reticular nucleus neurons were Fos - positive at 24 h. DISCUSSION : At variance with laboratory rats , pilocarpine - induced protracted seizures elicit in Proechimys limited neuronal death , and marked and long - lasting Fos induction in excitatory and inhibitory cortical and thalamic cell subsets . - pubmed
CONCLUSION : The visceral hyposensitivity induced by REM sleep deprivation may be associated with the increase of expression of CNS endocannabinoid receptor and decrease of its metabolism . - pubmed
In haemophilia A , linkage analysis with coagulation factor VIII ( F8 ) intragenic and/or neighbouring extragenic short tandem repeats ( STRs ) enables indirect tracking F8 pathogenic allelic variant - carriers . - pubmed
Thrombin generation in vitro in the presence of by - passing agents in siblings with severe haemophilia A. - pubmed
Previous data have shown an inter - individual difference in the thrombin generating capacity in vitro as well as phenotypic bleeding pattern among patients with severe haemophilia A ( FVIII : C activity below 1 % ) . - pubmed
Dexamethasone treatment inhibits VEGF production via suppression of STAT3 in a head and neck cancer cell line . - pubmed
MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival . - pubmed
In vivo , miR-34a induction by cisplatin was abrogated in p53 - deficient mice , a result that further confirms a role for p53 in miR-34a induction during cisplatin nephrotoxicity . - pubmed
Collectively , the results suggest that miR-34a is induced via p53 during cisplatin nephrotoxicity and may play a cytoprotective role for cell survival . - pubmed
METHODS : The study population included 504 subjects , 418 males and 86 females , aged 10 - 23 years old who have emigrated from Albania to Pogoniani - Greece and participated voluntarily in vaccination programmes against Hepatitis B. The serum samples were examined with enzyme immune assays for the immunological markers HBsAg , anti - HBc , anti - HBs and anti - HCV . - pubmed
Effects of Panax ginseng on tumor necrosis factor - alpha - mediated inflammation : a mini - review . - pubmed
Proinflammatory cytokines , chemokines , adhesion molecules and mediators of inflammation including inducible nitric oxide synthase , cyclooxygenase-2 and nitric oxide orchestrate the inflammatory response . - pubmed
The therapeutic potential of ginseng on TNF - alpha - mediated inflammatory diseases is also discussed . - pubmed
METHODS AND RESULTS : Using data from the Third National Health and Nutrition Examination Survey , we evaluated the associations between iron deficiency , hemoglobin , C - reactive protein ( CRP ) , and all - cause and cardiovascular mortality in 574 adults with self - reported heart failure . - pubmed
Iron deficiency was defined in both absolute and functional terms as a ferritin level & lt;100 mug / L or between 100 and 299 mug / L if the transferrin saturation was & lt;20 % . - pubmed
Iron deficiency was present in 61.3 % of participants and was associated with reduced mean hemoglobin ( 13.6 versus 14.2 g / dL , P=0.007 ) and increased mean CRP ( 0.95 versus 0.63 mg / dL , P=0.04 ) . - pubmed
In age- and sex - adjusted Cox proportional hazards models , hemoglobin , CRP , and transferrin saturation but not iron deficiency were significantly associated with all - cause and cardiovascular mortality . - pubmed
CONCLUSIONS : Iron deficiency is common in heart failure and is associated with decreased hemoglobin and increased CRP . - pubmed
Regulated ATF5 loss - of - function in adult mice blocks formation and causes regression / eradication of gliomas . - pubmed
Our past findings indicated that glioblastoma cells , but not neurons or glia , require the transcription factor ATF5 ( activating transcription factor 5 ) for survival . - pubmed
However , it was unknown whether interference with ATF5 function can prevent or promote regression / eradication of malignant gliomas in vivo . - pubmed
In this model , d / n - ATF5 expression is controlled by doxycycline and the promoter for GFAP , a marker for stem / progenitor cells as well as gliomas . - pubmed
Endogenous gliomas were produced with high efficiency by retroviral delivery of platelet - derived growth factor ( PDGF )- B and p53 - short hairpin RNA ( shRNA ) in adult bi - transgenic mice in which expression of d / n - ATF5 was spatially and temporally regulated . - pubmed
Induction of d / n - ATF5 before delivery of PDGF - B / p53 - shRNA virus greatly reduced the proportion of mice that formed tumors . - pubmed
Moreover , d / n - ATF5 induction after tumor formation led to regression / eradication of detectable gliomas without evident damage to normal brain cells in all 24 mice assessed . - pubmed
OBJECTIVE : To identify the IgE - binding epitopes in the allergen Der p 1 of main house dust mites , which can be recognized by the specific IgE in the sera from allergic individuals , and obtain a hypoallergen derived from the T - B epitope fused peptide for potential use in specific immunotherapy ( SIT ) . - pubmed
It is shown that bortezomib affects the amount of MRP1 gene mRNA , relocating the multifunctional protein YB-1 , dependent on Akt activity , from cytoplasm to nuclei of MCF-7 breast cancer cells . - pubmed
Anti - neutrophil cytoplasmic antibodies ( ANCA ) specific for one or several antigens : useful markers for subtypes of ulcerative colitis and associated primary sclerosing cholangitis . - pubmed
This study analyzed specificity of anti - neutrophil cytoplasmic antibodies ( ANCA ) in IBD patients and its clinical significance . - pubmed
RESULTS : pANCA were more frequently present in UC than in CD patients ( p<0.001 ) . - pubmed
ANCA titer correlated with the disease activity only in UC patients ( p<0.05 ) . - pubmed
UC patients more frequently had two or more ANCA specificities compared to CD patients ( p<0.01 ) . - pubmed
Multi - specific ANCA with ANA and ASMA had sensitivity of 67 % for PSC . - pubmed
Multi - specific ANCA with ANA and ASMA could be markers for PSC . - pubmed
ANCA specific to several antigens may worsen inflammation by reducing antimicrobial capacity of neutrophil proteases and cationic proteins . - pubmed
The aim of this study was to assess the role of fungal FBE and ME in colon carcinogenesis . - pubmed
Factors associated with OS were bisphosphonates use ( HR = 0.5 , p = 0.008 ) , elevated pre - treatment alkaline phosphatase ( HR = 2.9 , p = 0.003 ) and sunitinib induced HTN ( HR = 0.63 , p<0.0001 ) . - pubmed
HIV disease - related factors associated with greater volume abnormalities included CD4 cell count nadir , clinical staging , history of AIDS - defining events , infection age , and current age . - pubmed
The odds ratio for VF was markedly higher in subjects in the highest S1P quartile category compared with those in the lowest S1P quartile category after adjustment for confounders ( odds ratio 9.33 , 95 % confidence interval 2.68 - 32.49 ) . - pubmed
RESULTS : Only 1 % of erythrocytes were recovered in LRP without the hemolysis of erythrocytes . - pubmed
Patients with TB usually have high titers of specific IgG ; however , the carbohydrate associated with Fc - IgG usually lacks galactose . - pubmed
To assess the effect of this abnormal IgG in murine pulmonary TB , we evaluated the specificity of recognition to Mycobacterium tuberculosis antigens in vitro and protective effects in vivo comparing human intravenous immunoglobulin ( IVIg ) and IVIg treated with an endoglycosidase to remove the glycan residues ( EndoS - treated IVIg ) . - pubmed
Altogether , our results show that repeated MDMA exposure causes strong neural and behavioral adaptations and that inhibitory feedback mediated by alpha ( 2A )- adrenergic and 5 - HT ( 1A ) autoreceptors has an important role in the physiopathology of addictive behaviors . - pubmed
Firstly , we found that miR-452 directly regulates the expression of thyroid hormone receptor TRbeta1 in renal cancer cells . - pubmed
Monocyte chemotactic protein-1 -2518 gene polymorphism and susceptibility to spinal tuberculosis . - pubmed
BACKGROUND AND AIMS : Monocyte chemotactic protein-1 ( MCP-1 ) gene polymorphisms play important roles in regulating immunological reactions and may be associated with pulmonary tuberculosis . - pubmed
However , the relationship between the MCP-1 -2518 gene polymorphism and susceptibility to spinal tuberculosis remains unknown . - pubmed
We undertook this study to investigate the relationships between MCP-1 promoter 2518 genotype frequency and allele polymorphisms and susceptibility to spinal tuberculosis in a Chinese Han population . - pubmed
MCP-1 -2518 GG genotype was significantly associated with the onset of spinal tuberculosis ( OR = 2.306 , 95 % CI = 1.273 - 4.178 ) . - pubmed
The G and A allele frequencies were 61.5 % and 38.5 % , respectively , in the case group , and 52.1 % and 47.9 % in the control group ( p & lt;0.05 ) , the allele " G " of MCP-1 -2518 showed an association with an increased risk for spinal tuberculosis : OR = 1.777 , 95 % CI = 1.053 - 2999 , p = 0.03 in the dominant model ; OR = 1.67 , 95 % CI = 1.097 - 2.544 , p = 0.016 in the recessive model . - pubmed
CONCLUSIONS : The MCP-1 -2518 GG genotype and presence of the G allele may be associated with susceptibility to spinal tuberculosis in the Chinese Han population . - pubmed
STUDY DESIGN AND METHODS : A patient with beta - thalassemia intermedia and hereditary persistence of fetal hemoglobin presented for peripheral blood stem cell collection for autologous transplant for myeloma . - pubmed
[ A multicenter study on the validation of conversion factor for the conversion of BCR - ABL ( P210 ) transcript levels to the international scale in chronic myeloid leukemia ] . - pubmed
OBJECTIVE : To validate the conversion factor ( CF ) for the conversion of BCR - ABL ( P210 ) transcript levels to the international scale in chronic myeloid leukemia ( CML ) . - pubmed
CONCLUSION : Validation of CF examined the stability of the detection of BCR - ABL ( P210 ) transcript levels , which was necessary for the valid conversion of BCR - ABL ( P210 ) transcript levels to the international scale in CML . - pubmed
Here , we describe two genes , Deformed epidermal autoregulatory factor 1 ( Deaf1 ) and Adenosine A1 receptor ( Adora1 ) , that are differentially expressed and alternatively spliced in the pancreatic lymph nodes or islets of NOD mice and T1D patients to form dominant - negative non - functional isoforms . - pubmed
Loss of Deaf1 function leads to reduced peripheral tissue antigen expression in lymph node stromal cells and may contribute to a breakdown in peripheral tolerance , while reduced Adora1 function results in an early intrinsic alpha cell defect that may explain the hyperglucagonemia and resulting beta cell stress observed prior to the onset of diabetes . - pubmed
Since cinnarizine is a well - tolerated calcium channel blocker which has acceptable effect on both vertigo and migraine headache , we carried out this study to evaluate the efficacy and safety of this medication in vestibular migraine and also migraine with brainstem aura associated with vertigo . - pubmed
Tumor necrosis factor - alpha inhibitors alleviation of experimentally induced neuropathic pain is associated with modulation of TNF receptor expression . - pubmed
We recently demonstrated that tumor necrosis factor - alpha receptor ( TNFR ) levels in the spinal cord correlate with pain sensation in herniated disc patients in a rat chronic constriction injury ( CCI ) model . - pubmed
By using the sciatic nerve CCI model , we studied the effect of anti - TNF - alpha treatment on recovery from hypersensitivity and TNFR expression in the dorsal root ganglion ( DRG ) and dorsal horn ( DH ) . - pubmed
Anti - TNF - alpha treatment resulted in a significant alleviation of pain . - pubmed
Treated animals that showed a & gt;=50 % alleviation of pain exhibited a significantly reduced TNF R1 / R2 mRNA ratio compared with treated animals that recovered less well . - pubmed
These results demonstrate that attenuation of TNFR expression is associated with recovery from nerve injury and suggest that this may be one of the working mechanisms of anti - TNF therapies . - pubmed
Alzheimer ' s disease is a progressive neurodegenerative disorder that is characterized by extensive deposition of fibrillar amyloid - beta ( Abeta ) in the brain . - pubmed
Nonetheless , functional p53 has been observed in cervical cancer . - pubmed
HPV encodes an E6 oncoprotein that degrades the tumor suppressor p53 and abrogates cell cycle checkpoints . - pubmed
Nonetheless , functional p53 has been observed in cervical cancer . - pubmed
Histone H2B ubiquitination at lysine 120 ( H2Bub1 ) is regulated by RNF20 , an E3 ubiquitin ligase that is altered in many tumor types . - pubmed
The BCR - FS rate of patients with pT2+category tumors was significantly higher than that with pT3a category tumors with PSM but not significantly different from that with pT3a category tumors without PSM . - pubmed
This study showed that these nanoparticles were stored as non - toxic iron compounds : maghemite oxide or ferritin , which is promising for MRI detection of atherosclerotic plaques in clinics using these USPIOs . - pubmed
The Alliance for Clinical Trials in Oncology cooperative group has designed a phase III neoadjuvant clinical trial ( ALTERNATE trial ) which randomizes women with cT2 - 4 N0 - 3 M0 ER+/Her2- invasive breast cancer to either anastrozole , fulvestrant or its combination to assess a biomarker - driven treatment strategy to identify women with a low risk of disease recurrence . - pubmed
Bevacizumab - resistant FGBR pancreatic cancer cells were treated in vitro with bevacizumab , the recombinant human IL1 receptor antagonist anakinra , the monoclonal antibody against TGFbeta receptor type II TR1 , and a novel recombinant antibody binding CXCR1 / 2 ligands . - pubmed
Consistently , the combination of these agents with bevacizumab reduced the FGBR tumor burden and significantly prolonged mice survival compared with bevacizumab in monotherapy . - pubmed
Tumors from mice receiving the combination treatment showed significantly lower expression of IL6 and phosphorylated SMAD2 , higher expression of E - cadherin and lower levels of vimentin , and a significantly lower infiltration by CD11b cells compared with bevacizumab - treated controls . - pubmed
This study suggests that inhibition of IL1 , CXCR1 / 2 , and TGFbeta signaling pathways is a potential therapeutic approach to modulate the acquired resistance to anti - VEGF treatment by reversing epithelial - mesenchymal transition and inhibiting CD11b proangiogenic myeloid cells ' tumor infiltration . - pubmed
The SAPAP3 knockout ( KO ) transgenic mouse was developed as an animal model of OCD and related disorders ( OCRD ) . - pubmed
METHODS : Striatal and medial frontal cortex 9.4 Tesla proton spectra were acquired from young adult SAPAP3 KO and wild - type control mice to determine whether KO mice have metabolic and neurochemical abnormalities . - pubmed
Importance of adipocyte cyclooxygenase-2 and prostaglandin E2 - prostaglandin E receptor 3 signaling in the development of obesity - induced adipose tissue inflammation and insulin resistance . - pubmed
We examined the involvement of adipocyte cyclooxygenase-2 ( COX-2 ) and prostaglandin E2 ( PGE2 )- prostaglandin E receptor ( EP ) 3 - mediated signaling during hypertrophy and hypoxia in the development of obesity - associated adipose tissue ( AT ) inflammation and insulin resistance . - pubmed
The experiments were conducted with high - fat diet ( HFD)-induced obese rats , db / db mice , human subjects , and 3T3 - L1 and the human Simpson - Golabi - Behmel syndrome ( SGBS ) adipocytes ; the groups were treated with selective inhibitors of COX-2 [ celecoxib 30 mg / kg , half maximal inhibitory concentration ( IC50 ) 0.04 microM ] and EP3 ( L-798106 100 microg / kg , IC50 0.5 microM ) or a short interfering RNA . - pubmed
There were strong , positive correlations between adipocyte COX-2 and EP3 gene expressions and the AT TNF - alpha and monocyte chemotactic protein-1 contents and the homeostatic model assessment for insulin resistance in HFD - induced obese rats , as well as body mass index in human subjects . - pubmed
Treatment with COX-2 and EP3 inhibitors significantly reversed AT inflammatory gene and protein expressions ( -50 % ) and impaired glucose and insulin tolerance in db / db mice . - pubmed
Targeting inhibition of adipocyte COX-2 and EP3 during hypertrophy and hypoxia reversed the release of the augmented proinflammatory adipokines and the diminished adiponectin and also suppressed NF - kappaB and hypoxia - inducible factor-1alpha transcription activation . - pubmed
These findings suggest that adipocyte COX-2 PGE2 - EP3 - mediated signaling is crucially involved in the development of obesity - associated AT inflammation and insulin resistance.-Chan , P.-C. , Hsiao , F.-C. , Chang , H.-M. , Wabitsch , M. , Hsieh , P. S. Importance of adipocyte cyclooxygenase-2 and prostaglandin E2 - prostaglandin E receptor 3 signaling in the development of obesity - induced adipose tissue inflammation and insulin resistance . - pubmed
Prognostic implications of epithelial to mesenchymal transition related proteins ( E - cadherin , Snail ) and hypoxia inducible factor 1alpha in endometrioid endometrial carcinoma . - pubmed
Recently , hypoxia and hypoxia - inducible factor 1alpha ( HIF-1alpha ) signaling pathway were identified to have an essential role in the regulation of EMT phenotype . - pubmed
The aim of the study was to evaluate the prognostic impact of EMT - related proteins ( E - cadherin , Snail ) and HIF-1alpha in endometrioid endometrial carcinoma ( EEC ) among Egyptian women . - pubmed
Immunohistochemical evaluation of E - cadherin , Snail , and HIF-1alpha expression was performed using 50 cases of EEC . - pubmed
The frequency of immunopositivity for E - cadherin , Snail , and HIF-1alpha in our cases of EEC was 82 % , 28 % , and 66 % , respectively . - pubmed
E - cadherin and Snail have a predictive value in EEC . - pubmed
In conclusion , the current study reveals that both Snail and HIF-1alpha expressions are significantly associated with poor prognosis in EEC ; however , E - cadherin expression is considered a marker of good prognosis . - pubmed
E - cadherin and Snail expression has a predictive value in EEC management . - pubmed
ABCA1 and ABCG1 gene expression positively correlated with obesity indicators such as body mass index ( BMI ) ( r=0.522 , p=0.004 ; r=0.594 , p=0.001 , respectively ) and waist circumference ( r=0.403 , p=0.033 ; r=0.474 , p=0.013 , respectively ) . - pubmed
The development of obesity is associated with decreased IAT levels of RORa and LXRb mRNA ( p=0.016 and p=0.002 , respectively ) . - pubmed
These data suggest that the nuclear factor RORa can play a significant role in the regulation of cholesterol metabolism and control IAT expression of ABCA1 and ABCG1 , while the level of IAT LXRb gene expression may be an important factor associated with the development of obesity . - pubmed
De novo ALK kinase domain mutations are uncommon in kinase inhibitor - naive ALK rearranged lung cancers . - pubmed
INTRODUCTION : Anaplastic lymphoma kinase ( ALK ) rearranged lung adenocarcinomas are responsive to the multitargeted ALK inhibitor crizotinib . - pubmed
However , the presence of ALK mutations in crizotinib - naive tumors has not been widely reported and it is unclear if de novo ALK mutations affect the response to crizotinib . - pubmed
METHODS : We analyzed preclinical models of ALK rearranged lung cancers that were sensitive / resistant to ALK inhibitors , probed our institutional and other lung cancer databases for tumors with ALK kinase domain mutations , and evaluated tumor response to crizotinib . - pubmed
Previous ALK rearranged lung cancer cohorts did not report ALK kinase mutations in inhibitor - naive tumors . - pubmed
We identified one TKI - naive ALK rearranged tumor with an ALK kinase domain mutation : ALK - S1206F ( mutations at ALK - S1206 shifted crizotinib inhibitory curves only minimally in preclinical models ) . - pubmed
The never smoker whose tumor harbored de novo EML4 - ALK - E5;A20+ALK - S1206F only achieved a 4 - month radiographic response to crizotinib 250 mg twice daily . - pubmed
CONCLUSIONS : Combining data from our and prior cohorts , ALK kinase domain mutations were uncommon events ( & lt;3 % of cases ) in ALK inhibitor - naive ALK rearranged lung adenocarcinomas but their effect on intrinsic resistance to ALK inhibitors should be better evaluated . - pubmed
RORgammat is a master transcription factor of Th17 cells and considered as a promising drug target for the treatment of autoimmune diseases . - pubmed
Whereas Tiam1 genetic deficiency weakens IL-17A expression partially and inhibits the development of experimental autoimmune encephalomyelitis ( EAE ) , deletion of Rac1 in T cells exhibits more robust effects on Th17 cells and EAE . - pubmed
The clinical relevance of these findings is emphasized by pharmacological targeting of Rac1 that suppresses both murine and human Th17 cells as well as EAE . - pubmed
Thus , our findings highlight a regulatory pathway of Tiam1 / Rac1 in Th17 cells and suggest that it may be a therapeutic target in multiple sclerosis . - pubmed
RESULTS AND CONCLUSIONS : Abundant evidence has demonstrated that Bregs play a regulatory role in inflammatory , autoimmune , and tumor diseases , and regulatory B cells play different roles in different diseases , but future work needs to determine the mechanisms by which Bregs are activated and how these cells affect their target cells . - pubmed
Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro . - pubmed
CONCLUSION : Our study demonstrates that chicory inulin , as a nutritional supplement , may be beneficial for the patients with type 2 diabetes mellitus , and the metabolism - modulatory effect seems to be related with the inhibition of JNK and P38 MAPK pathways . - pubmed
We determined the involvement of afferent sensory neurons , calcitonin - gene - related peptide ( CGRP ) , lipid peroxidation , and nitric oxide ( NO ) biosynthesis in gastroprotection of H2S - releasing NaHS and CO - releasing tricarbonyldichlororuthenium ( II ) dimer ( CORM-2 ) against aspirin - induced injury . - pubmed
Particularly , lupane - type triterpenes have shown great ability to modulate multiple cancer - related signaling pathways and processes , including NF - kappaB , Wnt / beta - catenin , PI3K / Akt , apoptosis , and many other routes related to proliferation or cell death , which are uncontrolled in malignant tumors . - pubmed
Expression of claudin 1 , claudin 4 , and claudin 7 in colorectal cancer and its relation with CLDN DNA methylation patterns . - pubmed
Altered claudin expression has been described in colon , prostatic , ovarian , and breast carcinoma . - pubmed
We aimed our study to investigate whether claudin protein expression and methylation of CLDN can influence the tumorigenesis of colorectal cancer . - pubmed
Immunohistochemical staining was used to study protein expression in both tumor and the adjacent nonneoplastic mucosa of claudin 1 , 4 , and 7 . - pubmed
To detect the DNA methylation pattern of CLDN1 , 4 , and 7 , genomic DNA was extracted from both the tumor and the adjacent nonneoplastic mucosa . - pubmed
Cell membrane staining intensity of all claudins was found significantly lower in colorectal cancer tissues when compared to paired normal mucosa ( p & lt;= 0.001 ) . - pubmed
In normal mucosa , cytoplasm showed no staining for claudins in any patient , whereas in paired colorectal cancer tissues , significant cytoplasmic staining appeared both for claudin 1 ( p = 0.04 ) and claudin 4 ( p = 0.01 ) . - pubmed
Tumor samples were significantly hypomethylated in CLDN1 ( p & lt ; 0.05 ) . - pubmed
In conclusion , our results show that CLDN1 is significantly hypomethylated in tumor samples and that the membrane staining intensity for claudin 1 , 4 , and 7 is significantly lower in colorectal cancer tissues than in adjacent nonneoplastic tissue . - pubmed
Colorectal cancer cells showed dystopic cytoplasmic location of claudins . - pubmed
The CCL2 / CCR2 axis is also involved in pathological processes such as tumor growth and metastasis and hence is currently considered as an important drug target . - pubmed
BACKGROUND : The World Health Organization ( WHO ) defines atypical pituitary adenomas as tumours with a MIB-1 labelling index & gt;=3 % , p53 positivity and increased mitotic activity . - pubmed
Anti - citrullinated Protein Antibodies ( ACPA ) are excellent markers for Rheumatoid arthritis ( RA ) and are postulated to have a pathogenic role in the disease process . - pubmed
A multistep model for the evolution of the ACPA response in RA was proposed in which an initial break of tolerance causes , as " first hit " , " silent " production of ACPA without any clinical symptoms . - pubmed
The model further proposes that the ACPA immune response matures upon a certain ( unknown ) trigger , a " second hit " , which leads to epitope spreading , an increase in ACPA titres and extended isotype usage before clinical RA manifestations . - pubmed
This review , therefore , describes the current knowledge about ACPA Fab glycosylation in the pathogenesis of RA . - pubmed
Modifications of BDNF in plasma and/or in serum are associated with neurodegenerative and psychiatric disorders , cardiovascular diseases , metabolic syndrome and with mortality risk . - pubmed
Porphyromonas Gingivalis Elevated High - Mobility Group Box 1 Levels After Myocardial Infarction in Mice . - pubmed
High mobility group box 1 ( HMGB1 ) is a nuclear protein released from necrotic cells , inducing inflammatory responses . - pubmed
Due to tissue damage and necrosis of cardiac cells following myocardial infarction ( MI ) , HMGB1 is released , activating an inflammatory reaction . - pubmed
The level of HMGB1 protein in the P.g.-inoculated MI group was significantly higher than in the PBS - injected MI group on day 5 , but not on day 14 . - pubmed
Immunohistochemistry analysis revealed that HMGB1 was mainly expressed in cardiomyocytes , immune cells , and vascular endothelial cells in the PBS - injected MI group , while HMGB1 was seen broadly in degenerated cardiomyocytes , extracellular fields , immune cells , and vascular endothelial cells in the P.g.-inoculated MI group . - pubmed
A significant increase in the number of HMGB1 positive cells was observed in the P.g.-inoculated MI group compared to the PBS - injected MI group . - pubmed
after MI enhanced myocardial HMGB1 expression . - pubmed
There is a possible relationship between periodontitis and post - infarction myocardial inflammation through HMGB-1 . - pubmed
A higher P / F ratio and SP - D level , lower LDH and ferritin levels , higher platelet counts , and anti - MDA-5 antibody negativity are important prognostic markers in patients with CADM - associated RPIPs treated with PMX - DHP . - pubmed
Tumor Cell - selective Synergism of TRAIL- and ATRA - induced Cytotoxicity in Breast Cancer Cells . - pubmed
The present work focused on tumor cell - inhibiting effects of a combination of tumor necrosis factor - related apoptosis - inducing ligand ( TRAIL ) and all trans retinoic acid ( ATRA ) in breast cancer cells . - pubmed
MATERIALS AND METHODS : Breast cancer cell lines ( BT-20 , BT-474 , MDA - MB-231 , MDA - MB-436 , MDA - MB-453 , MCF-7 , SKBR3 , T47D , ZR-75 - 1 ) and the mammary epithelial cell line MCF-10A were treated with TRAIL and ATRA alone and in combination . - pubmed