Sentences with gene / disease entities

Human erythrocyte carbonic anhydrase B and C in chronic obstructive lung disease . - pubmed

The levels of carbonic anhydrase B and C isozymes in human red cells were determined using a quantitative immunological technique in patients with chronic obstructive lung disease . - pubmed

The produced quantity of lecithinase does not affect the toxicity of strains upon oral infection of the animals experimented . - pubmed

Abnormal bleeding is the key to early diagnosis , and the frequent use of sensitive HCG assays is the key to proper followup . - pubmed

Spontaneous elimination of HCG from the circulation following moler pregnancy , as indicated by sensitive assay , would predict a benign postmolar course ; no patient in the current series who once achieved undetectable levels of HCG developed malignant trophoblastic disease . - pubmed

The ability of the human interleukin-1 receptor antagonist , IL-1ra , to inhibit aerosolized antigen - induced airway hyperreactivity to i.v . - pubmed

In conclusion , IL-1ra inhibited antigen - induced airway hyperreactivity to i.v . - pubmed

substance P and bronchoalveolar lavage fluid inflammatory leukocyte influx in the guinea pig , in a time - dependent manner , suggesting that cytokines , such as IL-1 , may contribute to the pathophysiology surrounding this pulmonary anaphylaxis model . - pubmed

Interferon therapy for chronic NANB hepatitis . - pubmed

Characterization of keratinocyte plasminogen activator inhibitors and demonstration of the prevention of pemphigus IgG - induced acantholysis by a purified plasminogen activator inhibitor . - pubmed

Following only 15 min of ischemia , apical membrane enrichment of NaK - ATPase , normally a basolateral membrane ( BLM ) enzyme , had increased ( 1.6 + /- 0.6 vs. 2.9 + /- 1.2 , P less than 0.01 ) . - pubmed

Following ischemic injury ( 50 min ) , LAP staining could be seen within the cell and along the BLM . - pubmed

With cellular recovery from ischemic injury ( 5 days ) , LAP was again only visualized in the apical membrane . - pubmed

[ Plasma cholecystokinin level in chronic pancreatitis ] . - pubmed

Thus , in chronic pancreatitis ( cP ) , which leads to a decrease of digestive enzyme secretion , increases in plasma CCK may be postulated . - pubmed

H1 receptor antagonist treatment of chronic rhinitis . - pubmed

In patients with chronic rhinitis , H1 receptor antagonists play an important role in relieving the symptoms of sneezing , itching , and rhinorrhea . - pubmed

The proteolysis caused by purified calpain II was similar to proteolysis occurring during the formation of several experimental cataracts in rodents ; this suggested that the enzyme may play a role in cataract formation . - pubmed

Elevated serum follicle - stimulating hormone ( FSH ) levels and azoospermia were seen in all male patients after completion of induction and consolidation therapy as a result of germ cell and stem cell loss . - pubmed

Significance of elevated urinary N - acetyl - beta - D - glucosaminidase activity in chronic cadmium poisoning . - pubmed

N - Acetyl - beta - D - glucosaminidase ( NAG ) activity and beta 2 - microglobulin ( beta 2 - m ) concentration were measured in the urine of inhabitants of a cadmium - polluted area ( Cd ) , including patients with , or suspected , " itai - itai " disease and control subjects . - pubmed

Urinary NAG activity thus represents another useful indicator of renal tubular damage caused by Cd poisoning since the mechanisms for the excretion of NAG and beta 2 - m into urine are thought to be different . - pubmed

Expression of abl and other oncogenes is independent of metastatic potential in Abelson virus - transformed malignant murine large cell lymphoma . - pubmed

Analysis of the susceptibility of the transforming activities of lymphocyte - neoplasm DNAs to digestion with restriction endonucleases indicated that the same or closely related transforming genes were activated in independent neoplasms representative of the same stage of normal cell differentiation . - pubmed

The unfractionated extract and the fraction bound by Concanavalin A - Sepharose had similar ability to detect specific IgG in sera from patients with aspergillosis . - pubmed

An enzyme - linked immunosorbent assay for urinary albumin in patients with insulin - dependent diabetes mellitus . - pubmed

In this report , we developed an enzyme - linked immunosorbent assay ( ELISA ) for the measurement of urinary albumin ( UA ) and examined UA in 38 patients with insulin - dependent diabetes mellitus ( IDDM ) . - pubmed

the urinary protein of the cases with microalbuminuria consisted mainly of albumin , and in the case of nephropathy , an IgG band was also detected . - pubmed

Acute renal failure with ACE inhibition in aortic coarctation . - pubmed

The neurochemistry of vomiting involves serotonin and serotonin S3 receptors . - pubmed

Muscle fiber atrophy in leg muscles after botulinum toxin type A treatment of cervical dystonia . - pubmed

To further study possible distant effects of repeated BTX - A injections , we obtained percutaneous muscle biopsies of the vastus lateralis muscle from 11 patients with cervical dystonia . - pubmed

We postulate that the observed atrophy is due to distant effects of botulinum toxin causing progressive denervation - like changes in non - treated muscle . - pubmed

Adenoviral E1A - associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13 ) . - pubmed

We identify here that the p300 gene is fused to the MLL gene and that in - frame MLL - p300 fusion protein is generated in acute myeloid leukemia ( AML ) with t(11 ; 22)(q23 ; q13 ) . - pubmed

These findings suggest that the basis for the leukemogenesis of t(11 ; 22)-AML is the inability of p300 to regulate cell - cycle and cell differentiation after fusion with MLL . - pubmed

Prospective study of calcium channel blocker use , cardiovascular disease , and total mortality among hypertensive women : the Nurses ' Health Study . - pubmed

BACKGROUND : In several observational studies , patients prescribed calcium channel blockers had higher risks of cardiovascular diseases and mortality than those prescribed other antihypertensive medications . - pubmed

Women prescribed calcium channel blockers had a higher prevalence of ischemic heart disease . - pubmed

An association between calcium channel blocker use and myocardial infarction was apparent among women who had ever smoked cigarettes ( covariate - adjusted RR , 1.81 ; 95 % CI , 1.20 to 2.72 ) but not among never - smokers ( RR , 0.94 ; 95 % CI , 0.48 to 1.84 ) . - pubmed

CONCLUSIONS : In analyses adjusted only for age , we found a significant elevation in RR of total myocardial infarction among women who used calcium channel blockers compared with those who did not . - pubmed

The p52 / p65 heterodimer formed in the nucleus , bound specifically to the promoter of the tumor suppressor protein p53 , effecting a 25 to 30 - fold increase in the level of this protein . - pubmed

Analysis of gene - environment interaction in coronary artery disease : lipoprotein lipase and smoking as examples . - pubmed

Results from a prospective study on CAD risk in healthy middle - aged men show that the risk associated with the LPL - D9N variant , which has a modest effect on plasma triglyceride levels , is enhanced up to 10 fold , but only in men who smoke . - pubmed

The proposed mechanism for this LPL : smoking interaction on CAD risk is the subject of this review . - pubmed

Telomerase activity and hTERT mRNA in development and progression of adenoma to colorectal cancer . - pubmed

Telomerase activity and hTERT mRNA expression are upregulated in colorectal cancer . - pubmed

We examined telomerase activity by the fluorescence - based telomeric repeat amplification protocol method and analyzed the level of hTERT mRNA by real - time polymerase chain reaction in 74 surgically obtained neoplasms from 29 patients . - pubmed

These results suggest that telomerase activation occurs during the progression from low - grade to high - grade dysplasia in adenomas and increases steadily with the progression of the degree of dysplasia and invasion during colorectal carcinogenesis , and that hTERT mRNA expression is a feature of the late stage development of colorectal cancer . - pubmed

Through a genome - wide cDNA microarray , we identified that the paternally expressed gene 10 ( PEG10 ) was highly expressed in a great majority of hepatocellular carcinomas , although its expression was absent in normal liver cells . - pubmed

Exogenous expression of PEG10 conferred oncogenic activity and transfection of hepatoma cells with antisense S - oligonucleotides suppressing PEG10 resulted in their growth inhibition . - pubmed

These findings suggested that development of drug(s ) inhibiting PEG10 activity could be a novel approach for the treatment of hepatocellular carcinomas . - pubmed

Stress - induced release of HSC70 from human tumors . - pubmed

These findings indicate that HSC70 can be actively released from tumor cells and is indicative of a previously unknown mechanism by which immune modulators stimulate the release of intracellular HSC70 . - pubmed

This mechanism may account for the potent chaperokine activity of heat shock proteins recently observed during heat shock protein - based immunotherapy against a variety of cancers . - pubmed

Corticotropin and cortisone ; dosage and ratio of intramuscular and intravenous corticotropin ( ACTH ) and oral cortisone in treatment of certain dermatoses . - pubmed

Haemoglobin E in Burmese ; two cases of haemoglobin E disease . - pubmed

2 CASES OF THE NEONATAL FORM OF GENERALIZED CONGENITAL CYTOMEGALIC DISEASE ] . - pubmed

LPAM ( alpha 4 beta 7 integrin ) is an important homing integrin on alloreactive T cells in the development of intestinal graft - versus - host disease . - pubmed

We conclude that the alpha ( 4 ) beta ( 7 ) integrin is important for the invasion of alloreactive donor T cells into the gut and the subsequent development of intestinal GVHD and overall GVHD morbidity and mortality . - pubmed

UNLABELLED : Levels of some markers of coagulation and platelet activation such as prothrombin fragment 1 + 2 ( F1 + 2 ) thrombin - antithrombin complex ( TAT ) and von Willebrand factor ( vWF ) , are related to outcome in non ST - segment elevation acute coronary syndrome ( NSTEACS ) . - pubmed

AIM : To study changes of markers of coagulation and platelet activation during short term use of ticlopidine and clopidogrel in NSTEACS patients treated with aspirin and antithrombin . - pubmed

CONCLUSION : Short term use of ticlopidine in patients with NSTEACS treated with aspirin and unfractionated heparin was associated with lower levels of TAT and fibrinogen ( relative to control group ) on day 14 . - pubmed

Both ticlopidine and clopidogrel used in regimes with loading doses in NSTEACS patients treated with aspirin and antithrombin prevented acute phase elevation of vWF . - pubmed

Kinase Suppressor of Ras1 ( KSR1 ) functions as a positive modulator of Ras - dependent signaling either upstream of or parallel to Raf-1 , and pharmacologic inactivation of KSR1 may serve as a treatment for Rasdriven malignancies such as pancreatic cancer ( Xing , H. R. , Cordon - Cardo , C. , Deng , X. , Tong , W. , Campodonico , L. , Fuks , Z. , and Kolesnick , R. ( 2003 ) Nat . - pubmed

Preeclampsia and the C282Y mutation in the hemochromatosis ( HFE ) gene . - pubmed

PURPOSE : Muscle insulin resistance is characterized by the inability of a normal insulin concentration to produce a favorable rate of glucose uptake . - pubmed

METHODS : A review of the relative research from my laboratory and the scientific literature was performed to obtain information on the muscle insulin resistance of the obese Zucker rat and its response to exercise training . - pubmed

RESULTS : The insulin resistance of the obese Zucker rat results from defects in the insulin signaling cascade , which limits translocation of the glucose transporter GLUT4 to the plasma membrane upon insulin binding to its receptor . - pubmed

Exercise training improves the muscle insulin resistance of obese Zucker rat but does not correct the defects in insulin signaling or GLUT4 translocation . - pubmed

All patients had cerebrospinal fluid pleocytosis and WNV - specific IgM in the cerebrospinal fluid and/or serum . - pubmed

Urinary zinc excretion and serum insulin were significantly higher in the same group , although the insulinemia and the parameters of zinc nutritional status were not significantly correlated . - pubmed

PpGalec , a tandem repeat galectin expressed in the midgut of the sandfly Phlebotomus papatasi , is used by Leishmania major as a receptor for mediating specific binding to the insect midgut , an event crucial for parasite survival , and accounts for species - specific vector competence for the most widely distributed form of cutaneous leishmaniasis in the Old World . - pubmed

Tissue transglutaminase and celiac disease . - pubmed

Effects of histone deacetylase inhibitor FR901228 on the expression level of telomerase reverse transcriptase in oral cancer . - pubmed

We speculated whether or not the expression level of telomerase reverse transcriptase ( hTERT ) would be modulated by agents targeting epigenetics in oral cancer cell lines . - pubmed

In the present study , the epigenetic effects of the histone deacetylase ( HDAC ) inhibitor FR901228 on hTERT transcription in oral cancer cell lines were analyzed by RT - PCR . - pubmed

We performed indirect genetic association studies of SRD5A1 and SRD5A2 and the dihydrotestosterone / testosterone ratio that reflects the activity of 5alpha - reductase in 57 males with type 2 diabetes . - pubmed

Virus - specific CD8 + T cell responses play an important role in the natural course of infection ; however , the impact of certain CD8 + T cell responses in determining clinical outcome has not been fully defined . - pubmed

However , the finding is especially significant because HLA - B27 has also been shown to have a protective role in HIV infection . - pubmed

In conclusion , our results suggest a dominant role of HLA - B27 in mediating spontaneous viral clearance as well as viral evolution in HCV infection and mechanistically link both associations to a dominant novel CD8 + T cell epitope . - pubmed

Manganese superoxide dismutase ( Mn - SOD ) gene polymorphisms in urolithiasis . - pubmed

Polymorphism in manganese superoxide dismutase gene ( Mn - SOD ) is a new approach to identify its probable association with urolithiasis . - pubmed

A valine ( Val ) to alanine ( Ala ) substitution at amino acid 16 , occurring in the mitochondrial targeting sequence of the MnSOD gene , has been associated with an increase in urolithiasis risk . - pubmed

This study was conducted to investigate the association of MnSOD gene polymorphism with the risk of urolithiasis . - pubmed

MnSOD genotype determination may provide a tool to identify individuals who are at risk of urolithiasis . - pubmed

The assessment of diabetes compensation is based on glycated haemoglobin , and glycated albumin is also recommended in certain cases . - pubmed

Deciding on the therapy ( oral antidiabetic drugs vs. insulin therapy or a combination of both ) is based on diabetic care standards ; cooperation between the diabetologist and the dialysis doctor is desirable . - pubmed

The purpose of this study was to determine whether oral EM could improve the periprosthetic tissue profiles and reduce serum cytokine production in AL patients who are candidates for surgical revision . - pubmed

Our results demonstrate that oral EM reduces the inflammation of periprosthetic tissues , as manifested by the reduction of the numbers of infiltrating cells , CD68 + macrophages , RANKL+ cells , and TRAP+ cells . - pubmed

Dual oral antiplatelet therapy with aspirin and oral ADP - receptor antagonists , such as clopidogrel , has been the standard choice for prevention of ischemic events in patients with acute coronary syndrome and in those undergoing percutaneous coronary intervention . - pubmed

Cangrelor is a reversible , potent , competitive inhibitor of the ADP P2Y ( 12 ) receptor that is administered intravenously and rapidly achieves near complete inhibition of ADP - induced platelet aggregation . - pubmed

Despite an abundance of data describing expression of genes in the Candida albicans ALS ( agglutinin - like sequence ) gene family , little is known about the production of Als proteins on individual cells , their spatial localization or stability . - pubmed

Development of an ErbB - overexpressing A-431 optical reporting tumor xenograft model to assess targeted photodynamic therapy regimens . - pubmed

To better assess the efficacy of erbB - targeted therapies , it would help to have optical reporting human tumor xenograft models that abundantly express erbB receptors . - pubmed

A GFP / luciferase clone , A-431 / D4 , and an RFP / luciferase clone , A-431 / G4 , were obtained that exhibit erbB1 expression levels and tumor growth kinetics similar to the parental cells . - pubmed

To demonstrate the utility of the optical reporting clones , A-431 / G4 tumors were grown subcutaneously in nude mice and treated with vascular - targeted photodynamic therapy ( PDT ) , which targets the angiogenic consequences of erbB signaling . - pubmed

A-431 / D4 and A-431 / G4 optical reporting tumor models should also prove useful for assessing therapies that directly target the erbB1 receptor . - pubmed

Genetic revelations charge APOL1 variants with kidney disease susceptibility . - pubmed

Our data suggest that these tumors share a common genomic program that includes inactivation of a master regulator of the p53 and Rb pathways , CDKN2A / B , and activation of FGFR4 , Ras , and Hedgehog ( Hh ) signaling . - pubmed

The CDKN2A / B tumor suppressor is deleted in most patient samples . - pubmed

FGFR4 , which encodes a receptor tyrosine kinase , is activated in 20 % of tumors , predominantly by amplification of mutant , activating FGFR4 alleles . - pubmed

We also identified intragenic deletions affecting NF1 , a tumor suppressor and inhibitor of Ras , in 15 % of tumor samples . - pubmed

Deletion of NF1 and the presence of activating Ras mutations ( in 42 % of patients ) were mutually exclusive , suggesting NF1 loss is an alternative and potentially common mechanism of Ras activation in ERMS . - pubmed

The aim of the present study was to describe the effects of beta - blocker metoprolol monotherapy and combined with calcium channel inhibitor felodipin on digital microcirculation in primary Raynaud ' s syndrome . - pubmed

RESULTS AND CONCLUSIONS : Our investigation concludes that the concurrent administration of beta - blockers with calcium channel inhibitors positively reduces symptoms in patients suffering from Raynaud ' s syndrome . - pubmed

Upregulation of recepteur d'origine nantais tyrosine kinase and cell invasiveness via early growth response-1 in gastric cancer cells . - pubmed

Abnormal accumulation and activation of the recepteur d'origine nantais ( RON ) has been implicated in carcinogenesis of epithelial tumors . - pubmed

RON expression was induced by the tumor promoter , phorbol 12 - myristate 13 - acetate ( PMA ) , in gastric adenocarcinoma AGS cells . - pubmed

These results suggest that tumor promoter induces RON expression via Egr-1 , which , in turn , stimulates cell invasiveness in AGS cells . - pubmed

We previously reported that mice lacking surfactant protein A ( SP - A ) have increased airway hyperresponsiveness ( AHR ) during M pneumoniae infection versus wild - type mice mediated by TNF - alpha . - pubmed

Mast cells ( MCs ) have been implicated in AHR in asthma models and produce and respond to TNF - alpha . - pubmed

OBJECTIVE : Determine the contribution of MC / TNF interactions to AHR in airways lacking functional SP - A during Mp infection . - pubmed

METHODS : Bronchoalveolar lavage fluid was collected from healthy and asthmatic subjects to examine TNF - alpha levels and M pneumoniae positivity . - pubmed

RESULTS : Our findings indicate that high TNF - alpha levels correlate with M pneumoniae positivity in human asthmatic patients and that human SP - A inhibits M pneumoniae - stimulated transcription and release of TNF - alpha by MCs , implicating a protective role for SP - A. - pubmed

Using SP - A(-/-)Kit(W - sh / W - sh ) mice engrafted with TNF - alpha(-/- ) or TNF receptor ( TNF - R)(-/- ) MCs , we found that TNF - alpha activation of MCs through the TNF - R , but not MC - derived TNF - alpha , leads to augmented AHR during M pneumoniae infection when SP - A is absent . - pubmed

CONCLUSION : Our data highlight a previously unappreciated but vital role for MCs as secondary responders to TNF - alpha during the host response to pathogen infection . - pubmed

Effect of transcatheter renal arterial embolization combined with cryoablation on regulatory CD4+CD25 + T lymphocytes in the peripheral blood of patients with advanced renal carcinoma . - pubmed

OBJECTIVE : To analyze the effect of Argon - Helium cryosurgery ( AHCS ) combined with transcatheter renal arterial embolization ( TRAE ) on the differentiation of regulatory CD4 + CD25 + T cell ( Treg ) and its implication in patients with renal carcinoma . - pubmed

COX1 is largely constitutively expressed , whereas COX2 is induced at sites of inflammation and vascular injury . - pubmed

These observations have raised interest in the use of COX inhibitors and PGI ( 2 ) analogs in the management of pregnancy - associated and neonatal vascular disorders . - pubmed

Alabama birds also displayed lower inflammatory cytokine signaling and lower fever early in infection . - pubmed

Oxidized low - density lipoprotein ( ox - LDL ) is directly associated with chronic vascular inflammation . - pubmed

To understand whether thioredoxin1 ( Trx1 ) participates in an antiinflammatory defense mechanism in atherosclerosis , we investigated the effect of Trx1 on the expression of two adhesion molecules , vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) , in human umbilical vein endothelial cells ( HUVECs ) . - pubmed

These results suggest that Trx1 inherently suppresses VCAM-1 and ICAM-1 expression in vascular endothelia and may prevent the initiation of atherosclerosis by attenuating adhesion molecule expression . - pubmed

FokI polymorphism in the vitamin D receptor gene ( VDR ) and its association with lumbar spine pathologies in the Italian population : a case - control study . - pubmed

The association between VDR polymorphisms and spine disorders has been analyzed in different ethnic groups , focusing on the functional FokI polymorphism . - pubmed

The aims of this study were to evaluate , in the Italian white population , the VDR FokI polymorphism frequencies distribution in subjects with clearly defined lumbar spinal pathologies compared to asymptomatic controls and to analyze the interplay of genetic and conventional risk factors . - pubmed

In conclusion , the link we observed between VDR FokI variants and specific lumbar spine pathologies suggests that spinal tissue degeneration is influenced by the genetic background . - pubmed

Future studies should evaluate the signaling pathways involving alterations in VDR and influencing the development and/or progression of spine disorders . - pubmed

We find that gene expression patterns within early neoplasias are distinct from both normal and breast cancer patterns and identify a pattern of pro - oncogenic changes , including elevated transcription of ERBB2 , FOXA1 , and GATA3 at this early stage . - pubmed

Measurements of protein expression by immunohistochemistry on an independent set of early neoplasias confirms that ER pathway regulators FOXA1 and GATA3 , as well as ER itself , are consistently upregulated at this early stage . - pubmed

Therefore , the differential - binding profile for the six lineages could have implications in the immunopathology of Chagas ' disease , affecting the complex network of immune responses on which galectins mediate , thus providing linkage clues to the notion that different lineages may be related to different clinical forms of the disease . - pubmed

This study reported a case of an 11 - month - old male infant with mitochondrial disease characteristics and subclinical hypothyroidism ( a high thyrotropin level ) . - pubmed

This case adds to the growing literature of mitochondrial disorders caused by mitochondrial ATPase 6 mutations . - pubmed

Lymphocytotoxicity inhibition : a reliable method for HL - A typing of cultured cell lines . - pubmed

Despite normal or high total P-450 , in vivo drug metabolism was impaired in subjects with altered parenchyma , suggesting that other factors were limiting antipyrine elimination in liver disease . - pubmed

In a case of osteogenesis imperfecta with multiple fractures already from childhood , myelomatosis was diagnosed at the age of 52 years because of a serum M - component ( IgG , lambda ) , Bence Jones proteinuria , myeloma cells in the bone marrow , and osteolytic skeletal lesions . - pubmed

Scleroderma ( progressive systemic sclerosis ; PSS ) is a connective tissue disorder in which excessive collagen is deposited in the skin and internal organs . - pubmed

Results indicate that ( 1 ) the proliferative influence of serum of patients with PSS is not different from that of normal donors , ( 2 ) increased proliferation and procollagen gene expression are not linked in affected or unaffected dermal fibroblasts , and ( 3 ) affected PSS fibroblasts produce a stimulatory factor(s ) for procollagen gene expression to which they are differentially sensitive . - pubmed

Expression of the neuronal form of pp60c - src in neuroblastoma in relation to clinical stage and prognosis . - pubmed

The expression of the protooncogene c - src has been studied in specimens of childhood tumors with special reference to neuroblastoma and other tumors of neuronal origin . - pubmed

For comparison c - src gene expression was studied in seven neuroblastoma and neuroepithelioma cell lines . - pubmed

While pp60c - src was found in most tumors studied , the neuronal form was restricted to neuroblastomas ( 23 of 27 ) and retinoblastomas ( 3 of 3 ) and could not be detected in the other childhood tumors . - pubmed

A dominance of the neuronal form , pp60c - srcN , was exclusively found in the infant cases of neuroblastoma ( 9 of 12 ) , estimated to have good prognosis . - pubmed

These results indicate that pp60c - srcN might be a diagnostic marker in primitive childhood tumors . - pubmed

When expressed in higher amounts than pp60c - src , pp60c - srcN may be a positive prognostic marker in neuroblastoma , especially useful in the evaluation of infants . - pubmed

In addition , lack of pp60c - srcN seems to be incompatible with low stage neuroblastoma . - pubmed

To determine if increases in the target cell free intracellular Ca2 + concentration ( [ Ca2+]i ) are also important for cytotoxicity , we examined the effects of Ca2 + substitutes , promotors of Ca2 + influx ; and inhibitors of Ca2 + efflux on the cytolysis mediated by purified cytolysin . - pubmed

Ethacrynic acid , a potent inhibitor of glutathione S - transferases ( GST ) , has been shown to enhance the cytotoxicity of chlorambucil in drug resistant cell lines , but a definite mechanism has not been established . - pubmed

[ Experience with using automated insulin infusion systems in diabetes mellitus type 1 ] . - pubmed

Neurotoxicity of parathyroid hormone in uremia . - pubmed

The steady - state level of truncated myc RNAs in J558 was comparable to that in another plasma cell tumor line ( MPC-11 ) which harbors a translocated c - myc locus without an IAP element . - pubmed

Adenylate cyclase activity in kidney of partially nephrectomized uremic rats : decreased sensitivity to arginine - vasopressin in kidney medulla . - pubmed

Immunoglobulin E and A levels in atopic and anaphylactic children . - pubmed

IgE levels were high in both atopic and anaphylactic patients but higher in the atopic than in the anaphylactic group . - pubmed

A multiple - dose phase I trial of recombinant leukocyte A interferon in cancer patients . - pubmed

Eighty - one patients with a variety of refractory disseminated malignant neoplasms have been treated in the first multiple fixed - dose phase I trial of recombinant leukocyte A interferon ( IFL - rA ) . - pubmed

The toxic reactions seen with IFL - rA resembled those of nonrecombinant leukocyte interferon and included fever , chills , fatigue , anorexia , myalgia , headache , occasional nausea and vomiting , and dose - dependent reversible leukopenia and hepatic transaminase elevations . - pubmed

Serum haptoglobin as tumor marker . - pubmed

Interferon response in chronic myeloid leukaemia correlates with ABL / BCR expression : a preliminary study . - pubmed

alpha - Interferon ( IFN ) has been used to induce cytogenetic remission in chronic myeloid leukaemia ( CML ) , but there are few indicators to predict IFN response . - pubmed

The function and clinical significance of the newly discovered ABL / BCR mRNA has not been investigated for a correlation with CML prognosis or response to therapy . - pubmed

We have used a two - step reverse transcriptase polymerase chain reaction ( RT - PCR ) to detect the transcripts of the chimaeric genes BCR / ABL , ABL / BCR , as well as the normal ABL and BCR genes in 24 CML patients treated with IFN . - pubmed

However , 7/10 ABL / BCR mRNA positive patients achieved a major cytogenetic response to IFN ; but of the 13 ABL / BCR mRNA negative patients , only two achieved a major cytogenetic response ( P = 0.013 ) . - pubmed

A single parameter , oxygenated hemoglobin , can be used to quantify experimental irritant - induced inflammation . - pubmed

Rapid detection of transferrin receptor expression on glioma cell lines by using magnetic microspheres . - pubmed

A rapid method for detecting the presence of transferrin receptors ( TR ) on human glioblastoma - derived cell lines is presented . - pubmed

Seven established human glioblastoma - derived cell lines were assayed for the presence of TR with antibody - coated magnetic microspheres ( immunobeads ) . - pubmed

The immunobeads bound to glioblastoma cells in the presence of human anti - TR monoclonal antibodies to a significantly greater degree than to control cell lines ( P & lt ; 0.0001 ) . - pubmed

A 9L rat gliosarcoma cell line was used as a nonhuman control and did not demonstrate TR expression by either the immunobead assay or immunocytochemistry . - pubmed

First COMT inhibitor approved for Parkinson ' s disease . - pubmed

This relative resistance to HIV-1 infection did not extend to T cell line - adapted or syncytium - inducing ( SI ) primary viral isolates , was restricted by the envelope glycoprotein , and was associated with an increased production of the C - C chemokines RANTES , MIP-1alpha , and MIP-1beta . - pubmed

Resistance to infection and the high production of beta chemokines were characteristic of every CD4 + lymphocyte clone from the exposed - uninfected subjects . - pubmed

We have now identified the mechanism underlying this in vitro and in vivo resistance to infection : These individuals have inherited a homozygous 32 - bp nucleotide deletion ( delta32 ) within the gene encoding the coreceptor for primary NSI isolates of HIV-1 ( CCR5 ) . - pubmed

Twelve patients infected with the human immunodeficiency virus ( HIV ) and with CD4 cell counts below 100 cells / microliter received fluconazole daily ( 200 mg ; five patients ) or weekly ( 400 mg ; seven patients ) for fungal prophylaxis during a 6 - month period . - pubmed

METHODS : A DNA sequence encoding the ribozyme gene was incorporated into a eukaryotic expression vector ( pH beta Apr-1 neu ) and transfected into the human breast carcinoma cell line MCF-7 / Adr , which is resistant to adriamycin and expresses the MDR phenotype . - pubmed

CONCLUSIONS : We conclude that caspase-3 - mediated apoptosis causes extensive lymphocyte apoptosis in sepsis and may contribute to the impaired immune response that characterizes the disorder . - pubmed

Analgesic profile of the nicotinic acetylcholine receptor agonists , ( + ) - epibatidine and ABT-594 in models of persistent inflammatory and neuropathic pain . - pubmed

Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia . - pubmed

To elucidate the specific role of the TT genotype of MTHFR in the development of cerebral infarction with and without cognitive impairment , we determined the prevalence of hyperhomocyst ( e ) inemia and the C677 T genotypes of MTHFR in 143 patients with vascular dementia , 122 patients with cerebral infarction , and 217 healthy subjects matched for age and sex . - pubmed

Taken together , these findings indicate a possible role of MTHFR TT genotype combined with hyperhomocyst ( e ) inemia in the pathogenesis of vascular dementia . - pubmed

Similar to the relationship between homocystinuria due to severe MTHFR deficiency and severe cystathionine beta - synthase deficiency , the TT genotype of MTHFR in hyperhomocyst(e)inemic subjects is differentiated from the cases of the TT genotype without hyperhomocyst ( e ) inemia or hyperhomocyst(e)inemia without the TT genotype in the development of cerebrovascular disease . - pubmed

Platelet aggregation in response to ADP , collagen , and PGE1 was assessed , using optical aggregometry . - pubmed

Addition of PGE1 prior to addition of an agonist inhibited platelet aggregation in a concentration - dependent manner , whereas addition of PGE1 4 minutes after addition of ADP resulted in partial reversal of aggregation and fibrinogen binding . - pubmed

CONCLUSIONS AND CLINICAL RELEVANCE : A high concentration of sodium citrate in blood samples decreases plasma concentration of ionized calcium , resulting in reduced platelet aggregation and fibrinogen binding . - pubmed

Despite some expression of folate receptor alpha in human mesothelioma cells , internalization of methotrexate is predominantly carrier mediated . - pubmed

OBJECTIVE : As a response to a published report documenting some expression of folate receptor alpha in human mesothelioma , studies were carried out examining the role of this receptor versus that of the reduced folate carrier in the internalization of folate analogs in this neoplasm . - pubmed

Gene - expression analysis revealed prominent expression of the folate receptor in some but not all mesothelioma cell lines , and in only one case was expression of this receptor gene greater than expression of the reduced folate carrier gene . - pubmed

CONCLUSION : In view of the ongoing reduced folate carrier - mediated internalization that occurs in mesothelioma cells , these results would seem to argue against a role for the folate receptor in the internalization and cellular pharmacokinetics of methotrexate and other classic folate analogs in this neoplasm . - pubmed

Cytokines , especially TNF alpha , produced from macrophages / Kupffer cells , play a role in the induction of liver cell necrosis and apoptosis . - pubmed

It suggested that liver - associated T lymphocytes are involved in the inflammatory process associated with alcohol related liver injury through increased cytokine secretion ( TNF alpha ) . - pubmed

OBJECTIVES : To review the state of the art relating to protein S deficiency as a risk factor for thrombosis and to make recommendations regarding the use of protein S measurements in the assessment of thrombotic risk in individual patients and families . - pubmed

CONCLUSIONS : Consensus was reached on 16 recommendations for the use of protein S assays in the assessment of thrombotic risk in individuals and families . - pubmed

[ Anti - IgE ( Omalizumab ): a hope in the treatment of allergic diseases ] . - pubmed

Involvement of the anterior pretectal nucleus in the control of persistent pain : a behavioral and c - Fos expression study in the rat . - pubmed

In this study we used behavioral tests ( incisional pain and carrageenan - induced inflammatory pain ) and c - Fos expression changes to examine the involvement of the APtN in the control of persistent pain in rats . - pubmed

Low adiponectin levels predict type 2 diabetes in Mexican children . - pubmed

[ The expression of GABA - A receptor subunit alpha1 beta1 gamma2 mRNA in hepatic encephalopathic rats ] . - pubmed

The relationship between insulin resistance assessed by HOMA - IR and serum osteoprotegerin levels in obesity . - pubmed

AIM : We investigated the relationship between insulin resistance and serum osteoprotegerin ( OPG ) levels in healthy obese subjects and healthy lean controls . - pubmed

We used the homeostasis model assessment for insulin resistance ( HOMA - IR ) index as the index of insulin resistance . - pubmed

RESULTS : Obese subjects with increased insulin resistance ( Group III ) had lower OPG values than other groups ( 11.88+/-7.43 pg / ml , 16.39+/-6.39 pg / ml , 17.37+/-9.61 pg / ml , and 18.1+/-6.65 pg / ml , respectively ; Group I versus Group III p = 0.036 ; Group III versus Group IV p = 0.012 ) . - pubmed

In conclusion , insulin resistance in obesity is associated with decreased serum OPG levels and increased fibrinogen levels . - pubmed

The relationship between serum OPG levels and HOMA - IR may provide an insight into vascular endothelial dysfunction in obesity . - pubmed

Increased expression of plasma and cell surface co - stimulatory molecules CTLA-4 , CD28 and CD86 in adult patients with allergic asthma . - pubmed

To investigate whether there is altered expression and the clinical significance of soluble co - stimulatory molecules in asthmatic patients , plasma concentrations of sCTLA-4 , sCD28 , sCD80 and sCD86 in 51 adult allergic asthmatic adults with or without steroid treatment , and 35 sex- and age - matched control subjects were measured by enzyme - linked immunosorbent assay ( ELISA ) . - pubmed

Results showed that the plasma sCTLA-4 concentration was significantly higher in all asthmatic patients while sCD28 and sCD86 concentrations were significantly higher in steroid and non - steroid treated asthmatic patients , respectively , compared with control subjects ( all P & lt ; 0.01 ) . - pubmed

Significantly increased cell surface expression of CD28 but not CTLA-4 on PBMC was found in asthmatic patients compared with controls ( P & lt ; 0.05 ) . - pubmed

Serum total IgE concentration correlated positively and significantly with sCTLA-4 and sCD28 concentrations in allergic asthmatic patients ( both P & lt ; 0.05 ) . - pubmed

Osteoclasts from patients with autosomal dominant osteopetrosis type I caused by a T253I mutation in low - density lipoprotein receptor - related protein 5 are normal in vitro , but have decreased resorption capacity in vivo . - pubmed

Autosomal dominant osteopetrosis type I ( ADOI ) is presumably caused by gain - of - function mutations in the LRP5 gene . - pubmed

To investigate the effect of the T253I mutation in LRP5 on osteoclasts , we isolated CD14 + monocytes from ADOI patients and assessed their ability to generate osteoclasts when treated with RANKL and M - CSF compared to that of age- and sex - matched control osteoclasts . - pubmed

Cerebrotendinous xanthomatosis ( CTX ) is an autosomal recessive lipid storage disease caused by a deficiency of the mitochondrial enzyme 27 - sterol hydroxylase ( CYP27 ) . - pubmed

Volunteers were questioned about their bleeding history and the following tests were performed : complete blood count , prothrombin time / international normalized ratio , activated partial thromboplastin time , platelet function analysis , and platelet aggregation using standard turbidimetric methodology . - pubmed

The red - haired volunteers reported significantly more bruising , but there were no significant differences between the red - haired and dark - haired groups in hemoglobin concentration , platelet numbers , prothrombin time / international normalized ratio , or activated partial thromboplastin time . - pubmed

Previously , we reported that TTSS1 is involved in the cytotoxicity of the RIMD2210633 strain against HeLa cells . - pubmed

The cytotoxicity to HeLa cells was related to one of the newly identified secreted proteins encoded by VP1680 . - pubmed

Aberrant methylation of RASGRF2 and RASSF1A in human non - small cell lung cancer . - pubmed

RASSF1A , regarded as a TSG , has been extensively studied in lung cancer and other malignant tumors , whereas RASGRF2 has only been reported to possibly play a role in the pathogenesis of pancreatic cancer cell lines . - pubmed

The aims of our study were to i ) determine the methylation profile of RASGRF2 and ii ) compare the methylation profiles of RASGRF2 with RASSF1A in lung cancer . - pubmed

We examined RASGRF2 expression by reverse transcription PCR and aberrant methylation of RASGRF2 by methylation - specific PCR in lung cancer cell lines . - pubmed

Loss of RASGRF2 expression was presented in 36 % lung cancer cell lines while aberrant methylation of RASGRF2 was present in 30 % ( 3/10 ) non - small cell lung cancer ( NSCLC ) cell lines and in 25 % ( 1/4 ) small cell lung cancer ( SCLC ) cell lines . - pubmed

Among primary NSCLC , RASGRF2 and RASSF1A methylation was observed in 34 % ( 39/114 ) and 39 % ( 44/114 ) of cases respectively , while it was observed in only 7 % ( 4/57 ) and none of the corresponding non - malignant lung tissue . - pubmed

Frequent methylation and silencing of RASGRF2 in tumor cells may play an important role , different from that of RASSF1A , in the carcinogenesis of NSCLC . - pubmed

Of 632 women , aged 70 - 79 yr , 14.1 % of women were anemic ( hemoglobin & lt;120 g / L ) . - pubmed

An increase in loge selenium was associated with a reduced risk of anemia ( odds ratio per 1 SD increase = 0.63 , 95 % confidence interval = 0.47 - 0.84 ) , adjusting for age , education , chronic diseases , iron status , and serum interleukin-6 . - pubmed

IL-23 plays crucial roles in both immunity against pathogens and autoimmunity against self . - pubmed

In univariate analysis , leukocytes and CRP levels were associated with MVO , whereas pre - infarction angina and prior medication by aspirin or calcium channel antagonist appeared protective . - pubmed

Microvascular obstruction intensity positively correlated with baseline inflammation status assessed by C - reactive protein and leukocytes ( rho=0.43 and rho=0.44 ; p=0.003 ) , the peak of CK ( rho=0.56 ; p=0.01 ) or Troponin I ( rho=0.59 ; p=0.01 ) and negatively correlated with LVEF ( rho=-0.44 ; p=0.002 ) . - pubmed

tPA levels increased in FMF patients ( tPA levels of group 1 , 2 and 3 were 12.6 , 13.2 and 9.7 ng / ml , respectively ; p = 0.01 ) . - pubmed

Prolongation of PT and differences in tPA and P - selectin levels suggest that hypercoagulability may have a role in the etiopathogenesis of FMF . - pubmed

It may be possible to use PAI-1 as a marker for the attacks of FMF . - pubmed

CXCR5- and CCR7 - dependent lymphoid neogenesis in a murine model of chronic antigen - induced arthritis . - pubmed

The aim of this study was to establish a murine model of chronic arthritis in which the development of tertiary lymphoid tissue , a hallmark of human RA , is locally induced , and to characterize the roles of the homeostatic chemokine receptors CXCR5 and CCR7 in this process . - pubmed

Disease pathology was assessed up to 9 months in wild - type , CXCR5 - deficient , and CCR7 - deficient mice by determination of knee joint swelling and cellular and humoral immune responses , as well as by histologic analysis of arthritic knee joints . - pubmed

Analysis of the initiation and progression of AIA in wild - type , CXCR5-/- , and CCR7-/- mice revealed a reduction of acute inflammatory parameters in both knockout strains as well as significantly reduced joint destruction in CXCR5-/- mice . - pubmed

Cardiac troponin I as prognostic marker in heart failure patients discharged from emergency department . - pubmed

Despite evidence that cardiac troponin I ( cTnI ) identifies patients with advanced heart failure ( HF ) at risk of death , data on heterogeneous HF populations are scarce . - pubmed

Our purpose was to verify and analyze the prognostic role of cTnI in acute HF patients admitted to the emergency department . - pubmed

cTnI was detected in 45.5 % of HF patients . - pubmed

Viral and host correlates of serum resistin in simian AIDS . - pubmed

Resistin is an adipocytokine with a proposed dual role in metabolism and inflammation . - pubmed

This study utilizes the simian immunodeficiency virus ( SIV ) model of HIV / AIDS to investigate changes in serum resistin levels following dietary intervention and SIV infection and determine associations with measures of body composition and disease severity . - pubmed

Resistin levels , body composition ( n = 34 ) , and insulin resistance ( n = 16 ) were determined in healthy rhesus macaques . - pubmed

In healthy macaques consuming a standard diet , resistin levels correlated positively with total fat mass ( r = 0.49 ; p & lt ; 0.01 ) and tissue fat percent ( r = 0.53 ; p & lt ; 0.01 ) but failed to associate with measures of insulin resistance . - pubmed

Serum levels of MCP-1 and sTNF RII demonstrated no correlation with resistin in normal animals on a standard diet , while a significant positive correlation was observed following SIV infection ( r = 0.52 ; p & lt ; 0.0001 and r = 0.59 ; p & lt ; 0.0001 , respectively ) . - pubmed

Findings indicate a fundamental difference in the relationship between resistin and body composition following SIV infection and suggest that elevations in resistin parallel measures of disease severity including loss of body fat and viral replication . - pubmed

Recessive hereditary methemoglobinemia : two novel mutations in the NADH - cytochrome b5 reductase gene . - pubmed

Relation between degree of weight loss after bariatric surgery and reduction in albuminuria and C - reactive protein . - pubmed

Improvement in albuminuria and high - sensitivity C - reactive protein ( hs - CRP ) has also been reported . - pubmed

We investigated , at a weight control center in a community hospital setting , the relation between degree of surgical weight loss and reduction in the cardiovascular risk markers , albuminuria and hs - CRP . - pubmed

CONCLUSION : The results of our study have shown that obese adults experience a reduction in albuminuria and hs - CRP after bariatric surgery , with a greater reduction in hs - CRP observed with more surgical weight loss . - pubmed

STUDY DESIGN : To investigate if milk enzyme activities and the inflammatory interleukin 8 ( IL-8 ) level are increased in women with SCM , we measured sodium , potassium , NAGase , LDH , AcP , AP , and IL-8 in breastmilk samples collected at 2 months postpartum from 797 women in Guinea - Bissau , West Africa . - pubmed

BACKGROUND : Studies have suggested that vitamin D may be important for both insulin sensitivity and insulin secretion , and that supplementation with vitamin D may subsequently prevent development of type 2 diabetes . - pubmed

METHODS : Thirty - six subjects with type 2 diabetes , treated with metformin and bed - time insulin , were randomised to supplementation with cholecalciferol ( 40,000 IU per week ) versus placebo for 6 months . - pubmed

Estrogen receptor alpha ( ER alpha ) is a ligand - regulated transcription factor with a broad range of physiological functions and one of the most important classifiers in breast cancer . - pubmed

miR-22 overexpression leads to a reduction of ER alpha levels , at least in part by inducing mRNA degradation , and compromises estrogen signaling , as exemplified by its inhibitory impact on the ER alpha - dependent proliferation of breast cancer cells . - pubmed

Update on phase II studies of erythropoietin in acute myocardial infarction . - pubmed

Rationale and design of Exogenous erythroPoietin in Acute Myocardial Infarction : New Outlook aNd Dose Association Study ( EPAMINONDAS ) . - pubmed

Erythropoietin ( Epo ) is a hematopoietic hormone produced mainly by the kidneys in response to hypoxia . - pubmed

Exogenous erythroPoietin in Acute Myocardial Infarction : New Outlook aNd Dose Association Study ( EPAMINONDAS , EudraCTno . - pubmed

200500485386 ) is one of four ongoing randomized controlled trials , each testing the effects of Epo in & gt;or=100 patients with STEMI . - pubmed

EPAMINONDAS is a multicenter , prospective , double - blind , placebo - controlled , dose - finding study assessing intravenous moderate doses of human recombinant Epo ( epoietin - alpha , 100 or 200 IU / kg / die ) versus placebo , given on the first 3 days , in 102 patients with first ST - segment elevation myocardial infarction . - pubmed

The results of current phase II studies will help define the safety / efficacy profile of Epo for patients with STEMI . - pubmed

Functional autoantibodies against serpin E2 in rheumatoid arthritis . - pubmed

Levels of anti - serpin E2 autoantibodies in serum and synovial fluid from patients with RA , osteoarthritis ( OA ) , psoriatic arthritis , and ankylosing spondylitis , and/or from healthy individuals were assessed by enzyme - linked immunosorbent assay . - pubmed

Serpin E2 was overexpressed in RA synovial tissues as compared with OA synovial tissues . - pubmed

Significantly higher levels of anti - serpin E2 autoantibodies were present in samples of synovial fluid ( 28 % ) and serum ( 22 % ) from RA patients as compared with OA patients ( 0 and 6 % , respectively ) or with healthy individuals ( 6 % of sera ) . - pubmed

Most importantly , anti - serpin E2 autoantibodies isolated from RA sera reversed the inhibitory activity of serpin E2 by 70 % . - pubmed

Since anti - serpin E2 autoantibodies interfere with the inhibitory activity of serpin E2 toward serine proteases , they might facilitate the joint destruction in RA . - pubmed

Reduction of the activity of the purified lectin after oxidation by H2O2 , with remarkable fluorescence quenching , may suggest potential role for galectin-1 in free radical - induced , oxidative stress - mediated cardiovascular disorders . - pubmed

Expression and methylation status of the Syk gene in cervical carcinoma . - pubmed

Decrease or loss of Syk expression has been associated with a malignant phenotype and poor prognosis in a variety of cancers . - pubmed

This study aimed to determine the precise role of Syk in cervical cancer . - pubmed

METHODS : Methylation - specific PCR ( MSP ) and RT - PCR were utilized to analyze the methylation status and Syk mRNA expression in tissue samples from 20 normal controls , 50 CIN patients and 60 cervical cancer patients . - pubmed

RESULTS : Syk expression was detected in all 20 normal cervical tissues , as well as in all 18 CIN1 samples . - pubmed

Syk expression was found in 18 of 32 ( 56 % ) of CIN2/3 samples . - pubmed

CONCLUSION : The results indicate a potential link between the loss of Syk expression and cervical carcinogenesis . - pubmed

Metabolic syndrome criteria had the highest sensitivity for predicting fasting insulin ( 40 - 70 % ) , followed by uric acid ( 31 - 54 % ) , hsCRP ( 13 - 31 % ) , and HbA1c ( 7 - 21 % ) . - pubmed

Rho - kinase / nuclear factor - kappabeta / angiotensinogen axis in angiotensin II - induced renal injury . - pubmed

Glycosaminoglycan storage in neuroanatomical regions of mucopolysaccharidosis I dogs following intrathecal recombinant human iduronidase . - pubmed

Intrathecal ( IT ) recombinant human alpha - l - iduronidase ( rhIDU ) has been shown to reduce mean brain glycosaminoglycans ( GAGs ) to normal levels in mucopolysaccharidosis I ( MPS I ) dogs . - pubmed

[ Association of ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with cerebral infarction ] . - pubmed

OBJECTIVE : To study the association of ITGA9 gene rs189897 and rs2212020 polymorphisms and its haplotype with the occurrence of cerebral infarction ( CI ) . - pubmed

METHODS : In the venous blood samples from 250 patients with cerebral infarction and 250 control samples , the genotypes of rs189897 and rs2212020 of ITGA9 gene were identified by PCR - sequencing . - pubmed

CONCLUSION : rs189897 and rs2212020 in ITGA9 gene are closely related to CI , and its A - C haplotype is the protective factor against CI . - pubmed

Serum levels of vascular epithelial growth factor ( VEGF ) , which is considered to be a causative factor of endothelial lesions in POEMS syndrome , were not elevated throughout the course of this case . - pubmed

Immunoglobulin M nephropathy in a patient with systemic lupus . - pubmed

Immunoglobulin M ( IgM ) nephropathy is an uncommon glomerular disease characterized by IgM deposits in the mesangium . - pubmed

Renal biopsy revealed IgM nephropathy , with no clear evidence of lupus nephritis . - pubmed

Presently , recombinant tissue plasminogen activator is the only approved drug for the management of acute ischemic stroke . - pubmed

Twenty four hours after MCAo , motor performance was assessed and the animals were euthanized for estimation of brain malondialdehyde , glutathione , myeloperoxidase and nitric oxide levels . - pubmed

T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice . - pubmed

Carcinoembryonic antigen ( CEA ) is highly expressed on the surface of pancreatic adenocarcinoma cells ; we investigated the effects of cytolytic T cells that recognize CEA in a mouse model of pancreatic carcinoma . - pubmed

METHODS : Immune - competent mice that expressed the CEA transgene ( CEAtg ) in the intestinal and pulmonary tracts were given intrapancreatic injections of Panc02 CEA(+ ) cells ( express CEA and click beetle luciferase ) and tumors were grown for 10 days . - pubmed

RESULTS : Injection of the anti - CEA CAR T cells reduced the size of pancreatic tumors to below the limit of detection in all mice and produced long - term tumor eradication in 67 % of mice . - pubmed

T cells also eradicated CEA(+ ) fibrosarcoma cells injected 45 days later . - pubmed

CONCLUSIONS : Injection of T cells that target CEA can eradicate tumors grown from CEA(+ ) pancreatic carcinoma cells in the pancreas of CEAtg mice without autoimmune effects . - pubmed

Collectively , our data strongly suggest a critical role for CD4(+ ) T help in multiple phases of AdV - stimulated CTL responses , and could partially explain certain failures in AdV - based immunization trials targeting malignant tumors and chronic diseases that are often associated with compromised CD4(+ ) T cell population and function . - pubmed

Monocytosis at diagnosis was associated with lymphocyte count , deletions of chromosomes 17p and 11q , the extent of IgVH somatic hypermutation and Binet stage . - pubmed

RESULTS : Four - month oral resveratrol administration to diabetic rats ( 5 mg / kg / day ) alleviated the reduction of cardiac antioxidant enzymes activities ( 3.88 + - 0.48 vs. 1.49 + - 0.43 U , p & lt ; 0.05 for superoxide dismutase , and 2.72 + - 0.26 vs. 1.18 + - 0.19 nmol / min / mL , p & lt ; 0.05 for catalase ) and the enhancement of cardiac oxidative markers ( 5.01 + - 0.37 vs. 7.23 + - 0.51 ng , p & lt ; 0.05 for 8 - isoprostane , 6.03 + - 0.87 vs. 8.49 + - 0.52 mumol , p & lt ; 0.05 for nitrite / nitrate , and 0.44 + - 0.03 vs. 0.59 + - 0.04 , p & lt ; 0.05 for oxidized / reduced glutathione ratio ) , nuclear factor kappa B activity ( 0.37 + - 0.09 vs. 0.60 + - 0.11 , p & lt ; 0.05 ) and apoptosis rate ( 0.98 + - 0.28 vs.1.63 + - 0.16 , p & lt ; 0.05 ) . - pubmed

The use of incretin - based therapies , such as the dipeptidyl peptidase-4 ( DPP-4 ) inhibitors and glucagon - like peptide-1 ( GLP-1 ) analogs , is growing in patients with T2DM , due to their efficacy and tolerability profiles . - pubmed

As renal safety is a key factor when choosing treatment options to manage patients with T2DM , drugs that are suitable for use in patients with varying degrees of renal impairment without a requirement for dose adjustment , such as the DPP-4 inhibitor linagliptin , are of particular use . - pubmed

HLA - DPB1 * 04:01 allele is associated with non - obstructive azoospermia in Japanese patients . - pubmed

Previous studies reported that specific alleles and single nucleotide polymorphisms ( SNPs ) in the human leukocyte antigen ( HLA ) region were associated with NOA in East Asians . - pubmed

We attempt to expand upon previous findings by genotyping more HLA genes and to replicate SNP associations by focusing on Japanese NOA patients . - pubmed

HLA typing of six genes ( HLA - A , -B , -C , -DRB1 , -DQB1 , and -DPB1 ) was done on 355 NOA patients using SSO - Luminex assay while genotyping of two previously reported SNPs ( rs498422 and rs3129878 ) was done on 443 patients and 544 fertile males using TaqMan assay . - pubmed

We found that HLA - DPB1 * 04:01 [ corrected p value , P(c ) 7.13 x 10(-6 ) ; odds ratio ( OR ) 2.52 ] , DRB1 * 13:02 ( P(c ) 4.93 x 10(-4 ) , OR 1.97 ) , DQB1 * 06:04 ( P(c ) 8.94 x 10(-4 ) , OR 1.91 ) and rs3129878 ( p value 3.98 x 10(-4 ) ; OR 1.32 ) showed significant association with NOA , however , these loci are in linkage disequilibrium with each other . - pubmed

The conditional logistic regression tests showed that DPB1 * 04:01 is independently associated with NOA , confirming the involvement of the HLA region in the etiology of NOA in Japanese patients . - pubmed

Comment on " changes and regulation of the C5a receptor on neutrophils during septic shock in humans " . - pubmed

In mid-2011 , the addition of direct - acting antiviral agents ( DAAs)-the protease inhibitors boceprevir ( Victrelis , Merck ) and telaprevir ( Incivek , Vertex)-to pegylated interferon alpha-2a / b and ribavirin revolutionized the treatment of HCV infection by increasing cure rates across all fibrosis scores in patients with genotype 1 HCV infection . - pubmed

Findings from patients with dry eye have implicated defects in innate immunity ( Toll - like receptors , S100A and resident antigen - presenting cells ) , cytokines , chemokines and T helper ( TH)-cell subsets ( including TH1 and TH17 ) in disease pathogenesis . - pubmed

Tissue damage is treated by inhibiting matrix metalloproteinases . - pubmed

Breast cancer genes : looking for BRACA 's lost brother . - pubmed

AMP - activated protein kinase ( AMPK ) is a critical regulator of cellular metabolism and plays an important role in diabetes , cancer , and vascular disease . - pubmed

In the heart , AMPK activation is an essential component of the adaptive response to cardiomyocyte stress that occurs during myocardial ischemia . - pubmed

During ischemia - reperfusion , AMPK activation modulates glucose and fatty acid metabolism , mitochondrial function , endoplasmic reticulum ( ER ) stress , autophagy , and apoptosis . - pubmed

Pharmacological activation of AMPK prevents myocardial necrosis and contractile dysfunction during ischemia - reperfusion and potentially represents a cardioprotective strategy for the treatment of myocardial infarction . - pubmed

This review discusses novel mechanisms of AMPK activation in the ischemic heart , the role of endogenous AMPK activation during ischemia , and the potential therapeutic applications for AMPK - directed therapy . - pubmed

Trametinib radiosensitises RAS- and BRAF - mutated melanoma by perturbing cell cycle and inducing senescence . - pubmed

By immunohistochemistry the expression of Fas receptor and Fas - L was higher in the skin of lupus patients compared with controls . - pubmed

We also noted differences in Fas - L , -Fas , and -Bax proteins expression intensity in discoid lupus erythematosus patients in the epidermis , and hair follicles . - pubmed

CONCLUSIONS : Fas and Fas - L are expressed similarly in LP and DLE . - pubmed

Lumbar Disc Degeneration is Facilitated by MiR-100 - Mediated FGFR3 Suppression . - pubmed

BACKGROUND / AIMS : The pathogenesis of lumbar disc degeneration ( LDD ) involved activation of matrix metalloproteinase 13 ( MMP13 ) by differential expression of fibroblast growth factor receptor 1 ( FGFR1 ) and FGFR3 . - pubmed

METHODS : We examined the FGFR1 and FGFR3 levels and microRNAs ( miRNAs ) levels in the resected LDD discs , compared to the traumatized , non - LDD discs . - pubmed

RESULTS : The levels of FGFR1 and miR-100 were significantly higher , while the levels of FGFR3 were significantly lower , in LDD discs , compared to the control non - LDD discs . - pubmed

CONCLUSION : miR-100 may activate MMP13 through 3'UTR - suppressoin of FGFR3 mRNA to facilitate development of LDD . - pubmed

Possible Role of HER-2 in the Progression of Prostate Cancer from Primary Tumor to Androgen Independence . - pubmed

BACKGROUND : The expression of HER-2 in prostate cancer has been linked to disease progression . - pubmed

We analysed the presence of HER-2 expression in primary tumors in men undergoing radical prostatectomy , its association with clinical and pathological findings , and its expression in secondary circulating prostate cells ( CPCs ) during follow up , as well as links with biochemical failure and the effects of androgen blockade . - pubmed

HER-2 expression in the primary tumor was assessed using the HercepTest , CPCs were identified from blood samples using standard immunocytochemistry with anti - PSA and positive samples with the HercepTest to determine HER-2 expression . - pubmed

HER-2 was expressed in 20.8 % of primary tumors ; it was associated with vascular infiltration and older age , but not with other clinical pathological findings . - pubmed

Some 40.3 % of men had secondary CPCs detected , of which 38 % expressed HER-2 . - pubmed

After androgen blockade , men with HER-2 ( + ) positive secondary CPCs had a higher frequency of disease progression to castrate resistant disease . - pubmed

CONCLUSIONS : HER-2 plays a dual role in the progression of prostate cancer ; firstly it may increase the potential of tumor cells to disseminate from the primary tumor via the blood by increasing vascular infiltration . - pubmed

NOD2 Loss - of - Function Mutations and Risks of Necrotizing Enterocolitis or Focal Intestinal Perforation in Very Low - birth - weight Infants . - pubmed

BACKGROUND : NOD2 loss - of - function mutations , that is , R702W [ rs2066844 ] , G908R [ rs2066845 ] , and Leu1007fsinsC [ rs5743293 ] , have been linked to inflammatory bowel diseases . - pubmed

We assessed the effect of the NOD2 gene variants on the risk for major morbidities of the gastrointestinal tract , that is , NEC / FIP requiring surgery in multivariable logistic regression analyses . - pubmed

RESULTS : In the whole cohort of VLBW infants , carriers of & gt;= 2 NOD2 variant alleles had an increased risk for NEC requiring surgery ( odds ratio [ OR ] , 3.57 ; 95 % confidence interval [ CI ] , 1.27 - 10.04 ; P = 0.03 ) and NEC or FIP requiring surgery ( OR , 3.81 ; 95 % CI , 1.70 - 8.51 ; P = 0.004 ) as compared with wild - type genotypes . - pubmed

In a multivariable logistic regression analysis including gestational age , birth weight , gender , multiple birth , and inborn delivery , the association between & gt;= 2 NOD2 variant alleles and NEC surgery ( OR , 4.14 ; 95 % CI , 1.41 - 12.12 ; P = 0.009 ) , FIP surgery ( OR , 3.50 ; 95 % CI , 1.02 - 12.04 ; P = 0.047 ) , and NEC or FIP surgery ( OR , 4.10 ; 95 % CI , 1.74 - 9.73 ; P = 0.001 ) proved to be independent . - pubmed

Although probiotics had a protective effect on NEC and NEC or FIP requiring surgery , the NOD2 variants had no significant impact in this subgroup . - pubmed

CONCLUSIONS : VLBW infants carrying & gt;= 2 NOD2 genetic risk factors of inflammatory bowel disease in adults have an increased risk for severe gastrointestinal complications , such as NEC requiring surgery . - pubmed

BACKGROUND : The phosphodiesterase-5 inhibitor sildenafil has been shown to attenuate delayed cerebral ischemia ( DCI ) and improve neurologic function in experimental subarachnoid hemorrhage ( SAH ) . - pubmed

RESULTS : Depending on the modelling approach applied , albumin , body surface area , neutrophil , baseline tumour size and tumour shrinkage measures were identified as potential prognostic factors . - pubmed

PNMA2 , a member of the Paraneoplastic Ma Family ( PNMA ) , was identified through expression cloning by using anti - sera from patients with paraneoplastic disorder . - pubmed

Tissue expression studies showed that PNMA2 was predominantly expressed in normal human brain ; however , the protein was shown to exhibit abnormal expression profile as it was found to be expressed in a number of tumour tissues obtained from paraneopalstic patients . - pubmed

Cost - Effectiveness Analysis of Ugt1a1 Genotyping Before Colorectal Cancer Treatment with Irinotecan . - pubmed

Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease . - pubmed

In SEA , clinical studies are urgently needed to monitor ACT efficacy where K13 mutations are prevalent , test whether new combinations of currently available drugs cure ACT failures , and advance new antimalarial compounds through preclinical pipelines and into clinical trials . - pubmed

TNF - like weak inducer of apoptosis ( TWEAK ) receptor Fn14 is expressed by podocytes and Fn14 deficiency protects from experimental proteinuric kidney disease . - pubmed

Increased kidney Fn14 and CCL21 expression was also observed in rat proteinuric kidney disease induced by puromycin , and was localized to podocytes . - pubmed

The non - canonical NFkappaB pathway should be explored as a potential therapeutic target in proteinuric kidney disease . - pubmed

Nuclear and extranuclear - initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer . - pubmed

There are various ERalpha targeting agents that have been used for treatment of ER ( + ) breast tumors . - pubmed

The impact of direct nuclear activity of ER is very well characterized in ER ( + ) breast cancers and development and progression of endocrine resistance . - pubmed

In this mini - review , we will discuss the role of nuclear and extra - nuclear ER signaling and how they relate to therapy resistance in breast cancer . - pubmed

Safety Studies in Tumor and Non - Tumor - Bearing Mice in Support of Clinical Trials Using Oncolytic VSV - IFNbeta - NIS . - pubmed

Oncolytic VSV - IFNbeta - NIS is selectively destructive to tumors . - pubmed

Clinical translation of VSV - IFNbeta - NIS is underway in companion dogs with cancer and in human patients with relapsed hematological malignancies and endometrial cancer . - pubmed

Asymptomatic CMV Replication During Early Human Immunodeficiency Virus ( HIV ) Infection Is Associated With Lower CD4 / CD8 Ratio During HIV Treatment . - pubmed

BACKGROUND : A low CD4 / CD8 ratio in human immunodeficiency virus ( HIV )- infected individuals is associated with inflammation and higher risk of non - AIDS morbidity and mortality . - pubmed

In this study , we investigated the effect of subclinical cytomegalovirus ( CMV ) and Epstein - Barr virus ( EBV ) replication on CD4 + and CD8 + T - cell dynamics when antiretroviral therapy ( ART ) is started during early infection . - pubmed

CONCLUSIONS : Subclinical CMV replication in blood cells during early HIV infection and younger age were associated with lower CD4 / CD8 ratios during suppressive ART . - pubmed

NSP4 antibody levels in rotavirus gastroenteritis patients with seizures . - pubmed

BACKGROUND : Rotavirus nonstructural protein 4 ( NSP4 ) has been suggested as a pathogen of rotavirus - associated seizures . - pubmed

We investigated pre - existing serum antibodies against NSP4 and VP6 ( the most highly immunogenic rotavirus protein ) in patients with rotavirus gastroenteritis and its correlation with the occurrence of seizures . - pubmed

METHODS : With an enzyme - linked immunosorbent assay , IgG and IgA titers against NSP4 ( genotype [ A ] and [ B ] ) and VP6 were measured in acute - phase sera of 202 children aged 0.5 - 6.0 years with rotavirus gastroenteritis . - pubmed

Age , sex , hospital stay , presence of fever , white blood cell counts , C - reactive protein , vaccine status , IgG / IgA titers for VP6 , and IgA titers for both NSP4s did not differ between the groups . - pubmed

The seizure group showed a lower level of IgG against NSP4 [ A ] ( 184.5 vs. 163.0 U / mL ; P = 0.03 ) and NSP4 [ B ] ( 269.0 vs. 196.0 U / mL ; P = 0.02 ) . - pubmed

Even after adjusting these factors , anti - NSP4 [ A ] IgG ( OR 2.56 per 100 U / mL increment ; 95 % CI , 1.20 - 5.26 , P = 0.01 ) and anti - NSP4 [ B ] IgG ( OR 1.51 per 100 U / mL - increment ; 95 % CI , 1.04 - 2.22 , P = 0.03 ) were independently associated with protection against seizures . - pubmed

CONCLUSIONS : Serum anti - NSP4 IgG might protect rotavirus - associated seizures . - pubmed

Using tuberous sclerosis complex to understand the impact of MTORC1 signaling on mitochondrial dynamics and mitophagy in neurons . - pubmed

Constitutive activation of the MTOR pathway is a key feature of defects in the tuberous sclerosis complex and other genetic neurodevelopmental diseases , collectively referred to as MTORopathies . - pubmed

Erratum to : Usefulness of combining admission brain natriuretic peptide ( BNP ) plus hospital discharge bioelectrical impedance vector analysis ( BIVA ) in predicting 90 days cardiovascular mortality in patients with acute heart failure . - pubmed

The ENTPD1 promoter polymorphism -860 A & gt ; G ( rs3814159 ) is associated with increased gene transcription , protein expression , CD39 / NTPDase1 enzymatic activity , and thromboembolism risk . - pubmed

Ectonucleoside triphosphate diphosphohydrolase 1 ( NTPDase1 ) degrades the purines ATP and ADP that are key regulators of inflammation and clotting . - pubmed

We sequenced the ENTPD1 gene ( encoding NTPDase1 ) in 216 subjects then assessed genotypes in 2 cohorts comprising 2213 humans to identify ENTPD1 polymorphisms associated with venous thromboembolism ( VTE ) . - pubmed

Thus , the G allele of rs3176891 marks a haplotype associated with increased clotting and platelet aggregation attributable to a promoter variant associated with increased transcription , expression , and activity of NTPDase1 . - pubmed

The ENTPD1 promoter polymorphism -860 A & gt ; G ( rs3814159 ) is associated with increased gene transcription , protein expression , CD39 / NTPDase1 enzymatic activity , and thromboembolism risk . - pubmed

Bioinformatic analysis suggested that statin - induced miRNAs functions were primarily enriched in angiogenesis , integrin and platelet derived growth factor signaling pathways in UA patients . - pubmed

Replication of rs300774 , a genetic biomarker near ACP1 , associated with suicide attempts in patients with schizophrenia : Relation to brain cholesterol biosynthesis . - pubmed

CONCLUSIONS : Our results indicate that small - scale multiregional sampling and subsequent screening of low VAF somatic mutations might be a cost - effective strategy for identifying the majority of trunk mutations in gastric carcinoma . - pubmed

Glycosaminoglycan ( GAG ) enrichment is a dominant hallmark of early CAVD , but culture of valvular interstitial cells ( VICs ) in biomaterial environments containing pathological amounts of hyaluronic acid ( HA ) or chondroitin sulfate ( CS ) did not directly increase indicators of disease progression such as VIC activation or inflammatory cytokine production . - pubmed

However , HA - enriched matrices increased production of vascular endothelial growth factor ( VEGF ) , while matrices displaying pathological levels of CS were effective at retaining lipoproteins , whose deposition is also found in early CAVD . - pubmed

Nucleostemin regulates proliferation and migration of gastric cancer and correlates with its malignancy [ Retraction ] . - pubmed

Response to stretching was remarkably reduced in a rat model of LV hypertrophy , which also failed to increase titin phosphorylation . - pubmed

Comparison of HbA1c and glycated albumin as a control marker for newborn complications in diabetic women in a multicentre study in Japan ( Japan glycated albumin study group : study 2 ) . - pubmed

Background To clarify the relationship between glycated haemoglobin and glycated albumin concentrations during pregnancy with neonatal outcomes , a multicentre study was conducted by the Japanese Society of Diabetes and Pregnancy . - pubmed

On the other hand , the frequency of neonatal complications showed higher tendency of neonatal complications in the incidence of polycythaemia ( P = 0.094 ) and heavy - for - date ( P = 0.071 ) in the glycated albumin & gt;=15.8 % group compared with the glycated albumin & lt;15.8 group . - pubmed

Conclusions For the treatment of pregnant women with diabetes , glycated albumin would be a better marker than glycated haemoglobin . - pubmed

However , glycated albumin is also affected by obesity and albumin , and it is desirable to make a comprehensive judgment with glycated haemoglobin , random plasma glucose and other glycaemic index . - pubmed

Icariside II ameliorates ibotenic acid - induced cognitive impairment and apoptotic response via modulation of MAPK pathway in rats . - pubmed

ICS II administrated at doses of 8 and 16 mg / kg not only rescued behavioral performance , but also protected hippocampal neurons against neurotoxicity via suppressing the elevation of Bax / Bcl-2 ratio and the activation of caspase-3 . - pubmed

CONCLUSION : These results suggest that ICS II attenuates IBO - induced cognitive deficits , possibly via the regulation of calbindin expression and the inhibition of apoptotic response . - pubmed

In addition , the MAPK signaling pathway is implicated in the potential mechanisms of ICS II against IBO - induced excitotoxicity , indicating that ICS II is a promising compound for treatment of excitotoxicity - related diseases , including AD . - pubmed

Exome data analysis revealed significantly mutated genes previously linked to SBA ( TP53 , KRAS , APC , SMAD4 , and BRAF ) , recently reported potential driver genes ( SOX9 , ATM , and ARID2 ) , as well as novel candidate driver genes , such as ACVR2A , ACVR1B , BRCA2 , and SMARCA4 . - pubmed

Prior to infection five animals showed positive IFN - gamma responses to avian PPD ( PPD - A ) and four were positive in Map PCR ( IS900 ) on faeces . - pubmed

bovis infected animals reacted as early as day 14 with sustained higher PPD - B than PPD - A specific IFN - gamma responses , whereas the fourth animal ( with the strongest PPD - A response prior to infection ) showed sustained higher PPD - B specific IFN - gamma levels only a day 56 after infection . - pubmed

Later during infection , positive responses were found to ESAT-6 peptides in three infected bulls and to CFP-10 peptides in all four infected bulls . - pubmed

These data reveal a novel contribution of autoreactive CD8 T cells to autoimmune disease , in part , through CD4 follicular - like differentiation and functionality . - pubmed

Earlier studies have shown that treatment of keratinocytes and mouse skin with the green tea polyphenol ( -)- epigallocatechin-3 - gallate ( EGCG ) mitigated inflammation and increased the expression of caspase-14 while promoting epidermal differentiation and cornification . - pubmed

Topically applied nanoEGCG elicited a significant ( p<0.01 ) amelioration of psoriasiform pathological markers in IMQ - induced mouse skin lesions , including reductions in ear and skin thickness , erythema and scales , proliferation ( Ki-67 ) , infiltratory immune cells ( mast cells , neutrophils , macrophages , and CD4 + T cells ) , and angiogenesis ( CD31 ) . - pubmed

Importantly , a significant modulation of several psoriasis - related inflammatory cytokines and chemokines was observed compared to the high dose of free EGCG ( p<0.05 ) . - pubmed

Chaihu - Shugan - San Decoction Modulates Intestinal Microbe Dysbiosis and Alleviates Chronic Metabolic Inflammation in NAFLD Rats via the NLRP3 Inflammasome Pathway . - pubmed

We evaluate the effects of the Chaihu - Shugan - San decoction on intestinal microbe dysbiosis and chronic metabolic inflammation via the NLRP3 pathway in NAFLD rats that were fed a high - fat diet . - pubmed

In summary , the Chaihu - Shugan - San decoction modulated intestinal microbe dysbiosis , reduced fat accumulation , and alleviated inflammatory factor expression , which are all processes related to the NLRP3 inflammasome pathway in NAFLD rats . - pubmed

Nuclear factor - erythroid 2 - related factor-2 ( Nrf2 ) is a key transcription factor limits the tumor progression . - pubmed

Meanwhile , hyper activation of NF - kappaB transcription factors was witnessed in the tumor cells . - pubmed

Antagonistic activity of BITC , PEITC and SFN against cancer was related with the direct / indirect interaction with Nrf2 and NF - kappaB protein . - pubmed

We have also discussed the molecular interaction(s ) of the antagonistic effect of BITC , PEITC and SFN with Nrf2 and NF - kappaB to prevent cancer . - pubmed

Characteristics and outcomes of therapy - related myeloid neoplasms after peptide receptor radionuclide / chemoradionuclide therapy ( PRRT / PRCRT ) for metastatic neuroendocrine neoplasia : a single - institution series . - pubmed

PURPOSE : Peptide receptor radionuclide / chemoradionuclide therapy ( PRRT / PRCRT ) is an effective therapy for metastatic neuroendocrine neoplasia ( NEN ) , but therapy - related myeloid neoplasms ( t - MN ) remain of concern . - pubmed

AQP8 and AQP9 expression in patients with polycystic ovary syndrome and its association with in vitro fertilization - embryo transfer outcomes . - pubmed

The aim of the present study was to investigate aquaporin ( AQP ) 8 and AQP9 expression in patients with polycystic ovary syndrome ( PCOS ) and its association with in vitro fertilization - embryo transfer ( IVF - ET ) outcomes . - pubmed

A total of 45 patients with PCOS undergoing IVF - ET ( test group ) and 50 patients with oviduct obstruction or ovarian cyst ( control group ) were assessed for the mRNA expression of AQP8 and AQP9 in ovarian tissues by reverse transcription - quantitative ( RT - q)PCR . - pubmed

In conclusion , AQP8 and AQP9 are differentially expressed in ovarian tissues of patients with PCOS vs. normal control subjects . - pubmed

The expression of AQP8 is closely associated with the occurrence and development of oocytes , whereas the expression of AQP9 is associated with the success rate of pregnancy in patients with PCOS . - pubmed

Sinomenine retards LPS - elicited inflammation via down - regulating CCAT1 in HaCaT cells . - pubmed

Sinomenine pre - administration maintained cell viability , blocked apoptosis and relieved inflammation with the decrease in cleaved caspase-3 /- 9 and inflammatory factors . - pubmed

LINC00342 regulates cell proliferation , apoptosis , migration and invasion in colon adenocarcinoma via miR-545 - 5p / MDM2 axis . - pubmed

METHODS : The LINC00342 expressions in COAD tissues were detected via qRT - PCR and in situ hybridization analysis . - pubmed

RESULTS : LINC00342 was over - expressed in COAD tissues and LINC00342 overexpression was related to the poor prognosis of COAD patients . - pubmed

In COAD tissues and cell lines , LINC00342 expression was positively correlated to MDM2 expression , while it was negatively correlated to miR-545 - 5p expression . - pubmed

LINC00342 knockdown suppressed COAD tumor growth in vivo . - pubmed

Microbiota - Derived Metabolites Suppress Arthritis by Amplifying Aryl - Hydrocarbon Receptor Activation in Regulatory B Cells . - pubmed

Butyrate supplementation suppresses arthritis in a Breg - dependent manner by increasing the level of the serotonin - derived metabolite 5 - Hydroxyindole-3 - acetic acid ( 5 - HIAA ) , which activates the aryl - hydrocarbon receptor ( AhR ) , a newly discovered transcriptional marker for Breg function . - pubmed

It has been reported that angiotensin II ( Ang - II ) damages the function of EPCs in atherosclerotic plaque through induction of oxidative stress . - pubmed

Our study results indicated that Sesn2 facilitated the viability of EPCs After treatment with Ang - II , as well as provided a potential therapeutic target to alleviate the progression of atherosclerosis . - pubmed

Marein ameliorates Ang II / hypoxia - induced abnormal glucolipid metabolism by modulating the HIF-1alpha / PPARalpha / gamma pathway in H9c2 cells . - pubmed

Treating angiotensin II / hypoxia - stimulated H9c2 cells with marein led to decreasing cell surface area , intracellular total protein , atrial natriuretic peptide , and free fatty acids levels , but increasing glucose level . - pubmed

The effect of nutmeg essential oil constituents on Novikoff hepatoma cell viability and communication through Cx43 gap junctions . - pubmed

Disappearance of a highly unusual clone , 46,XY , del(7)(p12),t(9;22)(q34;q11 ) in chronic myeloid leukemia after treatment with recombinant interferon and cytosine arabinoside . - pubmed

Toxicity was limited to asymptomatic SGOT elevations in 3 patients and nausea and vomiting in 4 patients that required cessation of therapy in 2 . - pubmed

The purpose of the present studies was to compare the pharmacodynamic profile of the new ACE inhibitor cilazapril with the beta - adrenoceptor antagonist propranolol in healthy subjects and in hypertensive patients . - pubmed

Phospholipase A2 , leukotriene C4 and prostaglandin E2 levels in aqueous humour of guinea pigs with experimental S - antigen induced autoimmune uveitis . - pubmed

Purified S - antigen was used to induce experimental autoimmune uveitis in 42 guinea pigs . - pubmed

In aqueous humour the increase in phospholipase - A2 and proteins as well as myeloperoxidase measured from iris - ciliary blocks correlated well with the severity of uveitis evaluated by clinical grading . - pubmed

Of these biochemical parameters , only gamma glutamyl transpeptidase was significantly elevated in test animals with experimental autoimmune uveitis . - pubmed

Effects of insulin perfusion and altered glucose concentrations on heart function in 3 - day and 6 - week diabetic rats . - pubmed

Diabetes is known to result in depression of myocardial function , whereas hearts from insulin - treated diabetic rats exhibit functional characteristics similar to controls . - pubmed

In the present study , we have studied the effect of insulin perfusion on cardiac performance of 3 - day and 6 - week streptozotocin ( STZ ) diabetic rats . - pubmed

These results suggest that diabetes results in a loss of myocardial sensitivity to insulin which seems to occur as early as 3 days after induction of diabetes with STZ . - pubmed

The study also demonstrates that the beneficial effects of in vivo insulin treatment on myocardial alterations induced by diabetes are not due to its direct myocardial effects . - pubmed

The application of radioimmunoassay of insulin , C - peptide , gastrin , glucagon , vasoactive intestinal polypeptides ( VIP ) , somatostatin , human pancreatic polypeptides ( hPP ) , substance P and neurotensin to detect endocrine tumors of the pancreas and other organ systems is undoubtedly important in the clinical management of patients suspected of having tumors that secrete these hormones . - pubmed

Response to fibrinolytic activity and factor VIII - related antigen to stimulation with desmopressin in hyperlipoproteinemia . - pubmed

Factor VIII was higher than normal in most patients with hyperlipoproteinemia ; the level increased after stimulation with DDAVP in every patient . - pubmed

In addition , the immune dysfunctions that characterize some human diseases , such as cancer , depend not only on the immune system per se , but also at least in part , on altered secretion of immunomodulating neurohormones , including MLT and opioid peptides . - pubmed

The study was performed in 90 patients with advanced solid neoplasms , who received IL-2 at a dose of 3 million IU / day subcutaneously for 6 days a week for 4 weeks plus MLT at a daily dose of 40 mg . - pubmed

The results were compared to those in 40 cancer patients treated with IL-2 alone . - pubmed

GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose - stimulated insulin release . - pubmed

The rat insulinoma cell line RIN 1046 - 38 loses glucose - stimulated insulin secretion as a function of time in culture . - pubmed

None of the patients experienced severe leukopenia at the time of diagnosis , but the mean lymphocyte count decreased to 495 / mm3 ( range 100 to 830 / mm3 ) and 2 patients had inverted CD4 / CD8 T - cell ratios . - pubmed

Endometrial expression of mRNA encoding epidermal growth factor receptor in normal and leiomyomatous uteri throughout the menstrual cycle . - pubmed

CONCLUSION : This data suggest that endometrial EGFR mRNA expression varies in association with the histologic changes of the normal menstrual cycle , and may be associated with the presence of leiomyomata uteri . - pubmed

Hypertriglyceridemic effect of fructose is mainly due to an increase in hepatic production of VLDL . - pubmed

Interferon and thymic hormones in the therapy of human myocarditis and idiopathic dilated cardiomyopathy . - pubmed

The aim of this study was to evaluate the efficacy of interferon - alpha ( IFN ) and thymomodulin in the treatment of idiopathic myocarditis and IDC . - pubmed

Our results suggest that treatment of myocarditis and/or IDC with IFN or thymomodulin induces an earlier and significantly superior clinical improvement than conventional therapy alone . - pubmed

Immunolocalisation of the kinin moiety and bradykinin ( B2 ) receptors on synovial fluid neutrophils in rheumatoid arthritis . - pubmed

Generation of Alzheimer beta - amyloid protein in the trans - Golgi network in the apparent absence of vesicle formation . - pubmed

beta - amyloid protein ( A beta ) formation was reconstituted in permeabilized neuroblastoma cells expressing human Alzheimer beta - amyloid precursor protein ( beta APP ) harboring the Swedish double mutation associated with familial early - onset Alzheimer disease . - pubmed

Does insulin resistance unite the separate components of the insulin resistance syndrome ? - pubmed

The observation that M loaded on both factors suggests that a resistance to insulin action may provide the mechanism uniting the features of the insulin resistance syndrome . - pubmed

Transforming growth factor - beta ( TGF - beta ) has been shown to stimulate extracellular matrix formation and inhibit proteolytic matrix degradation in periodontal wound healing . - pubmed

Short - chain fatty acids inhibit intestinal trefoil factor gene expression in colon cancer cells . - pubmed

Intestinal trefoil factor ( ITF ) gene expression was detected in five colon cancer cell lines . - pubmed

We conclude that butyrate inhibits ITF expression in colon cancer cells and that this effect may be mediated transcriptionally and independently of its effects on differentiation . - pubmed

Bispecific antibodies capable of simultaneously binding a tumor surface antigen and the T - cell receptor / CD3 complex are capable of inducing polyclonal immune effector cells to destroy targeted tumor cells . - pubmed

The bispecific ligand - antibody conjugate described in this study is a chemical conjugate between an anti - CD3 monoclonal antibody ( MAb ) and folic acid , the ligand for a high - affinity surface receptor expressed on the surface of choroid plexus tumors . - pubmed

SV11 mice transgenic for SV40 large T antigen and its promoter develop solid choroid plexus tumors in the brain . - pubmed

Sustained high - level expression of full - length human factor VIII and restoration of clotting activity in hemophilic mice using a minimal adenovirus vector . - pubmed

The successful prophylactic treatment of hemophilia A by frequent infusions of plasma concentrates or recombinant factor VIII ( hFVIII ) indicates that gene therapy may be a potential alternative for the treatment of the disease . - pubmed

The functionality of the protein was confirmed by the restoration of blood coagulation capacity in MiniAdFVIII - treated hemophilic mice , as determined by tail clipping observations . - pubmed

METHODS : Maternal and fetal circulating angiogenin concentrations were compared at birth between 16 pregnancies with SGA ( 7 delivered vaginally and 9 delivered by elective cesarean section ) and 46 pregnancies with AGA ( 27 delivered vaginally and 19 delivered by cesarean section ) . - pubmed

However , maternal serum angiogenin levels were significantly higher than those in fetal serum within both SGA and AGA infant pregnancies . - pubmed

CONCLUSION : These results suggest that there is no difference in angiogenin synthesis between SGA and AGA pregnancies . - pubmed

Scar , a member of the WASp protein family , was discovered in Dictyostelium discoideum during a genetic screen for second - site mutations that suppressed a developmental defect . - pubmed

Possible involvement of endothelin-1 and nitric oxide in the pathogenesis of proliferative diabetic retinopathy . - pubmed

BACKGROUND : Overproduction of endothelin-1 ( ET-1 ) and nitric oxide ( NO ) in the retina is demonstrated in experimental diabetic animals . - pubmed

To clarify the possible involvement of ET-1 and NO in the pathogenesis of diabetic retinopathy , the authors examined the vitreous levels of these principal endothelium - derived vasoactive substances in patients with proliferative diabetic retinopathy ( PDR ) . - pubmed

RESULTS : Endothelin-1 levels ( mean + /- SE ) were 21.5 + /- 1.7 pg / mL in the vitreous of patients with PDR and 16.7 + /- 0.7 pg / mL in the vitreous of patients with macular hole . - pubmed

CONCLUSION : These results indicate that ET-1 and NO may be related in the pathogenesis of PDR . - pubmed

Proinsulin C - peptide has been reported to have some biological activities and to be possibly involved in the development of diabetic microangiopathy . - pubmed

Attenuation of hemolysate - induced cerebrovascular endothelial cell injury and of production of endothelin-1 and big endothelin-1 by an endothelin - converting enzyme inhibitor . - pubmed

BACKGROUND : Endothelin-1 ( ET-1 ) is a potent and long - acting vasoconstrictive peptide that has been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage ( SAH ) . - pubmed

ET-1 has been shown to be present in the cerebrospinal fluid of patients after SAH , and substances produced during hemolysis of subarachnoid blood clots are believed to be responsible for stimulating the production of ET-1 . - pubmed

Activation of the c - Jun N terminal kinase pathway in an animal model of Parkinson ' s disease . - pubmed

We studied the pattern of activation of the c - Jun N terminal kinase ( JNK ) signal transduction pathway during the course of a subacute MPTP mouse model of Parkinson ' s disease . - pubmed

[ Study of reactions for detection of the rheumatoid factor in the course of syphilis ] . - pubmed

Identification and clinical relevance of receptor activator of nuclear factor kappaB ligand expression of myeloma cells . - pubmed

Microgranular and t(11;17)/PLZF - RARalpha variants of acute promyelocytic leukemia also present the flow cytometric pattern of CD13 , CD34 , and CD15 expression characteristic of PML - RARalpha gene rearrangement . - pubmed

Homogeneous expression of CD33 was observed in 76 % of the classical APL cases and in 100 % of the microgranular cases . - pubmed

Additionally , we have studied two cases of PLZF - RARalpha APL that also displayed the same immunophenotype described for classical APL . - pubmed

Thus , the immunophenotypic profile highly characteristic of the PML - RARalpha gene rearrangement was also observed in microgranular and PLZF - RARalpha variants of APL . - pubmed

Polyploid formation via chromosome duplication induced by CTP : phosphocholine cytidylyltransferase deficiency and Bcl-2 overexpression : identification of two novel endogenous factors . - pubmed

Alterations in the alpha2 isoform of Na , K - ATPase associated with familial hemiplegic migraine type 2 . - pubmed

A number of missense mutations in the Na , K - ATPase alpha2 catalytic subunit have been identified in familial hemiplegic migraine with aura . - pubmed

Here , we investigate the proatherogenic role of NKT cells in an adoptive transfer model of atherosclerosis , using as recipients immune - deficient , atherosclerosis - susceptible RAG1(-/-)LDLR(-/- ) mice . - pubmed

The total serum from hypercholesterolemic mice leads to a small but significant activation of Valpha14Jalpha18 T - cell receptor - expressing hybridoma line by dendritic cells that is CD1d - dependent . - pubmed

The patient carrying the last duplication presents sex reversal , Peters ' anomaly and renal cysts and the duplication is located 4Mb away from the HSD17B1 gene , coding a key enzyme of testosterone biosynthesis . - pubmed

Apixaban is an oral , direct Factor Xa inhibitor that is being developed by Bristol - Myers Squibb Co and Pfizer Inc. Apixaban is currently undergoing phase III clinical trials for cerebrovascular ischemia , deep vein thrombosis and lung embolism , and phase II clinical trials for coronary artery disease . - pubmed

Mutation in the HPGD gene encoding NAD + dependent 15 - hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing ( ICNC ) . - pubmed

CONCLUSIONS : The involvement of 15 - PGDH in the pathogenesis of ICNC may open up interesting perspectives into the function of this enzyme in nail morphogenesis / development . - pubmed

Some soluble markers , including soluble mesothelin and osteopontin , have been previously proposed for MPM diagnosis but none has been validated yet . - pubmed

Soluble mesothelin , assessed in blood and in pleural effusion , seems to be the most promising candidate . - pubmed

Despite sometimes a good sensitivity , other potential markers as osteopontin are of little interest for MPM diagnosis because of a low specificity . - pubmed

In conclusion , the present data do not justify the use of biology for MPM diagnosis in routine yet but rather suggest a need for a continuing evaluation of soluble mesothelin in clinical studies and the search for other potential tumor markers . - pubmed

[ Cerebral proteolysis of amiloid - b peptide : relevance of insulin - degrading enzyme in Alzheimer ' s disease ] . - pubmed

One of the distinctive features of AD is the excessive accumulation of amyloid - b ( Ab ) peptide in the brain . - pubmed

IDE expression and activity are significantly decreased in AD brains compared to age - matched controls . - pubmed

An autosomal recessive form of hereditary spastic paraplegia ( AR - HSP ) is primarily caused by mutations in the SPG7 gene , which codes for paraplegin , a subunit of the hetero - oligomeric m - AAA protease in mitochondria . - pubmed

In the current study , sequencing of the SPG7 gene in the genomic DNA of 25 unrelated HSP individuals / families led to the identification of two HSP patients with compound heterozygous mutations ( p. G349S / p. W583C and p. A510V / p. N739KfsX741 ) in the coding sequence of the SPG7 gene . - pubmed

We used a yeast complementation assay to evaluate the functional consequence of novel SPG7 sequence variants detected in the HSP patients . - pubmed

By acting as a scaffolding protein , Cav-1 plays crucial roles in the regulation of various physiologic and patho - physiologic processes including oncogenic transformation and tumorigenesis , and tumor invasion and metastasis . - pubmed

Genetic background affects susceptibility to ileocolitis in mice deficient in two intracellular glutathione peroxidases , GPx1 and GPx2 . - pubmed

The C57BL/6 ( B6 ) GPx1/2 double - knockout ( DKO ) mice have mild ileocolitis , and 129S1 / Sv ( 129 ) DKO mice have severe inflammation . - pubmed

We used diet to modulate ileocolitis ; a casein - based defined diet with AIN76A micronutrients ( AIN ) attenuates inflammation compared to conventional LabDiets . - pubmed

Replacement therapy with factor VIII ( FVIII ) concentrates has become the mainstay of treatment for hemophilia , but about 30 % of patients with a severe disease develop neutralizing antibodies against FVIII , which can lead to treatment resistance and an increased risk of bleeding . - pubmed

High - dose FVIII ITI appears to induce immune tolerance more rapidly than low - dose protocols and with a reduced risk of bleeding episodes . - pubmed

A large set of estrogen receptor beta - interacting proteins identified by tandem affinity purification in hormone - responsive human breast cancer cell nuclei . - pubmed

Estrogen receptors alpha ( ER - alpha ) and beta ( ER - beta ) play distinct biological roles in onset and progression of hormone - responsive breast cancer , with ER - beta exerting a modulatory activity on ER - alpha - mediated estrogen signaling and stimulation of cell proliferation by mechanisms still not fully understood . - pubmed

Functional annotation by bioinformatics analyses of the 303 proteins that co - purify with ER - beta from nuclear extracts identify several new molecular partners of this receptor subtype that represents nodal points of a large protein network controlling multiple processes and functions in breast cancer cells . - pubmed

This probably occurs by correcting diabetes - linked increased clearance of thiamine , maintaining activity and expression of thiamine pyrophosphate - dependent enzymes that help counter the adverse effects of high glucose concentrations - particularly transketolase . - pubmed

Thiamine supplementation prevented the development of early - stage nephropathy in diabetic rats and reversed increased urinary albumin excretion in patients with type 2 diabetes and microalbuminuria in two recent clinical trials . - pubmed

Visfatin is known to play a role in obesity - related metabolic diseases and inflammatory conditions . - pubmed

Here , the role of visfatin in FFA - induced inflammation was investigated in hepatocytes . - pubmed

The expression of visfatin is closely associated with the expression of proinflammatory cytokines in FFA - induced inflammation and is significantly decreased by NF - kappaB inhibition in HepG2 cells . - pubmed

Visfatin may play a role in FFA - induced inflammation in hepatocytes through the NF - kappaB pathway . - pubmed

IL-22 , but not IL-17 , dominant environment in cutaneous T - cell lymphoma . - pubmed

Recently , interleukin ( IL )- 22 - producing T cells were reported in skin of patients with AD . - pubmed

In this study , we investigated expression levels of T ( H ) 22 - and T ( H ) 17 - related molecules in lesional skin and sera isolated from patients with CTCL . - pubmed

Phosphorylation of STAT3 was also assessed in lesional skin of CTCL and psoriasis by immunohistochemistry . - pubmed

RESULTS : IL-22 , IL-10 , IL-4 , CCL20 , and CCR6 mRNA and protein levels , but not IL-17A , IL-17F , IL-23p19 , IL-8 , or IL-20 , were significantly elevated in lesional skin of CTCL . - pubmed

Phosphorylation of STAT3 was detected in epidermis of CTCL skin . - pubmed

Moreover , serum IL-22 , IL-10 , and CCL20 levels were increased in CTCL and correlated with disease severity . - pubmed

CONCLUSIONS : Our results suggest that IL-22 is important in establishing the tumor microenvironment for CTCL . - pubmed

Enhanced expression of CCL20 may explain epidermal hyperplasia and migration of CCR6(+ ) cells , such as Langerhans cells , into lesional skin . - pubmed

Relatively low expression of IL-17 may explain the lack of neutrophils in lesions of CTCL , which correlates with bacterial infections that commonly occur in skin affected by CTCL . - pubmed

[ Effect of acupuncture on contents of beta - endorphin in the plasma and hypothalamus in rats with stress - induced gastric mucosal injury ] . - pubmed

Compared with the corresponding model groups , the gastrointestinal propulsion rate was increased remarkably in the prevention group ( P & lt ; 0.05 ) , and the gastric mucosal ulcer indexes and the contents of plasma beta - EP level were decreased obviously in both treatment and prevention groups ( P & lt ; 0.05 , P & lt ; 0.01 ) . - pubmed

CONCLUSION : Acupuncture of ST 36 , CV 12 and PC 6 can promote the repair of gastric mucosal injury and improve gastrointestinal function , which may be related to its effects in reducing plasma beta - EP and upregulating hypothalamic beta - EP level . - pubmed

Monoamine oxidase - B ( MAO - B ) inhibitor has been used as neuroprotectants to treat the motor deficits of Parkinson ' s disease ( PD ) . - pubmed

IgG4 - Related Perineural Disease . - pubmed

Retrospective review of 106 patients with IgG4 - related disease identified 21 peripheral nerve lesions in 7 patients . - pubmed

IgG4 - related disease of the peripheral nervous system is characterized by orbital or paravertebral localization , perineural mass formation , and rare neurologic symptoms . - pubmed

The term " IgG4 - related perineural disease " seems appropriate to describe this entity . - pubmed

Treatment of CD4 + T cells with Virus - Like Particles ( VLP ) containing Vpx results in the loss of SAMHD1 expression that correlates with an increased permissiveness to HIV-1 infection and accumulation of reverse transcribed viral DNA without promoting transcription from the viral LTR . - pubmed

Importantly , CD4 + T - cells from patients with Aicardi - Goutieres Syndrome harboring mutation in the SAMHD1 gene display an increased susceptibility to HIV-1 infection that is not further enhanced by VLP - Vpx - treatment . - pubmed

These results highlight the crucial role of SAMHD1 in mediating restriction of HIV-1 infection in quiescent CD4 + T - cells and could impact our understanding of HIV-1 mediated CD4 + T - cell depletion and establishment of the viral reservoir , two of the HIV / AIDS hallmarks . - pubmed

METHODS : To evaluate the estrogenic effect of SG , we first examined estrogen receptor ( ER ) activation by SG treatment in breast adenocarcinoma cells and confirmed the estrogenic effect of SG in vivo ovariectomized rats . - pubmed

RESULTS : SG significantly increased ERalpha phosphorylation , and its downstream effectors , extracellular signal - regulated kinase ( ERK ) and protein kinase B ( Akt ) phosphorylation in breast adenocarcinoma cells . - pubmed

CONCLUSION : Taken together , these data indicate that SG has phytoestrogen - like properties through ERK and Akt activation , implying that it could be protective and beneficial for the management of menopausal symptoms . - pubmed

Significance of osteopontin in the sensitivity of malignant pleural mesothelioma to pemetrexed . - pubmed

High immunohistochemical expression of SPP1 / OPN was observed in two of three MPM patients who had a partial response to PEM - based chemotherapy . - pubmed

PEM has antitumor effects in MPM cells dependent on SPP1 / OPN overexpression resulting in AKT activation . - pubmed

Our results suggest that SPP1 may be used as a single predictive biomarker of the effectiveness of PEM treatment in MPM . - pubmed

Preventive effects of siRNA targeting PPARgamma gene on steroid - induced osteonecrosis in rabbits . - pubmed

UNLABELLED : PURPOSES / AIM : Glucocorticoid steroids can induce expression of PPARgamma gene and enhance adipogenesis by bone marrow mesenchymal stem cells ( BMSCs ) , which may result in osteonecrosis of the femoral head . - pubmed

We hypothesized that siRNA targeting PPARgamma gene may prevent steroid - induced adipogenesis and osteonecrosis in rabbit . - pubmed

The purpose of this study was to evaluate the preventive effects of siRNA targeting PPARgamma gene on steroid - induced adipogenesis and osteonecrosis . - pubmed

CONCLUSION : siRNA targeting PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent steroid - induced osteonecrosis in rabbit . - pubmed

The sptC gene encodes a precursor composed of a signal peptide , an N - terminal propeptide consisting of a core domain ( N * ) and a linker peptide , a subtilisin - like catalytic domain , a polycystic kidney disease domain ( PkdD ) , and a chitin - binding domain ( ChBD ) . - pubmed

Platelets , cyclooxygenases , and colon cancer . - pubmed

Activated platelets , in response to tissue damage , induce a proinflammatory program involving the aberrant expression of cyclooxygenase ( COX )- 2 , which leads to increased tissue concentrations of the proinflammatory and protumorigenic prostaglandin E2 . - pubmed

In the current study we evaluated the added value of a combined protocol of blood oxygen level dependent ( BOLD ) imaging during hyperoxic challenge ( termed hemodynamic response imaging ( HRI ) ) in an orthotopic mouse model for glioblastoma under anti - angiogenic treatment with B20 - 4.1.1 , an anti - VEGF antibody . - pubmed

In glioblastoma tumors , the elevated HRI indicated progressive angiogenesis as further confirmed by histology . - pubmed

Genetics : BCL11A - targeting triple - negative breast cancer ? - pubmed

Furthermore , PFO+ subjects had an increased incidence of acute mountain sickness ( AMS ) at ALT1 concomitant with significantly lower peripheral O2 saturation ( SpO2 ) . - pubmed

Dab2IP ( DOC-2 / DAB2 interacting protein ) is a GTPase - activating protein which is involved in various aspects of brain development in addition to its roles in tumor formation and apoptosis in other systems . - pubmed

Biochemical and Functional Comparisons of mdx and Sgcg(-/- ) Muscular Dystrophy Mouse Models . - pubmed

The mdx mouse , which is dystrophin - deficient , has long been used to model this disease . - pubmed

Histologically the Sgcg(-/- ) mice displayed increased fibrosis and variable fiber size . - pubmed

By quantitative Evan 's blue dye uptake and hydroxyproline content two key disease determinants , membrane permeability and fibrosis respectively , were also proven worse in the Sgcg(-/- ) mice . - pubmed

Abeta ( 1 - 40 ) peptide supramolecular assembly and fibril formation processes are widely recognized to have direct implications in the progression of Alzheimer ' s disease . - pubmed

Desflurane preconditioning protects human umbilical vein endothelial cells against anoxia / reoxygenation by upregulating NLRP12 and inhibiting non - canonical nuclear factor - kappaB signaling . - pubmed

Desflurane preconditioning enhanced HUVEC survival and protected the cells against A / R injury , and our results suggested that this process involved the upregulation of NLRP12 and the inhibition of non - canonical NF - kappaB signaling . - pubmed

BACKGROUND : Tissue factor ( TF ) is involved in tumor growth and metastasis and contributes to venous thromboembolism ( VTE ) in cancer , including gynecological malignancies . - pubmed

RESULTS : D - Dimer , MV TF PCA , and sCD62P , but not the tumor marker , CA-125 , significantly differentiated patients with malignant ( n=40 ) from those with benign tumors ( n=15 ) and healthy controls ( n=34 ) . - pubmed

In cancer patients , only D - Dimer and CA-125 correlated with the FIGO stage . - pubmed

CONCLUSIONS : MV TF PCA , but not plasma TF antigen , may provide valuable additional information for the diagnostic work - up of women with suspected ovarian cancer . - pubmed

TAMOF is a devastating microangiopathy that can occur in association with the new onset of T1DM , and should be considered with the onset of thrombocytopenia , renal failure , and raised LDH . - pubmed

Studies of CD40L - deficient patients reveal the critical role of CD40L - CD40 interaction for the function of T , B , and dendritic cells . - pubmed

METHODS : After observing the improvement of refractory disseminated mycobacterial infection in a CD40L - deficient patient by recombinant human IFN - gamma ( rhIFN - gamma ) adjuvant therapy , we investigated macrophage functions from CD40L - deficient patients . - pubmed

RESULTS : Macrophages from CD40L - deficient patients exhibited defective fungicidal activity and reduced oxidative burst , both of which improved in the presence of rhIFN - gamma but not sCD40L. - pubmed

In addition , the improvement of macrophage immune responses by IFN - gamma suggests this cytokine as a potential therapeutic option for patients with CD40L deficiency . - pubmed

The risk for PD in these groups does not linearly increase with glucosylceramide ( GC ) accumulation or with acid beta - glucocerebrosidase ( GCase ) activity . - pubmed

Incidence of human cytomegalovirus infection and T - cell response in patients with psoriasis before and during antitumour necrosis factor - alpha therapy . - pubmed

Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease . - pubmed

CD1 - pcy / pcy mice , a juvenile model of PKD , daily treated with 13 [ Formula : see text]g of mambaquaretin-1 for 99 d , developed less abundant ( by 33 % ) and smaller ( by 47 % ) cysts than control mice . - pubmed

Significant reductions in the phosphorylation of signaling molecules focal adhesion kinase , extracellular signal - regulated kinases 1 and 2 , and v - Akt murine thymoma viral oncogene were observed in male MIPbeta1KO islets when compared to controls . - pubmed

Female MIPbeta1KO mice did not develop glucose intolerance or reduced beta - cell mass until 16 weeks post - tamoxifen . - pubmed

Glucose intolerance remained in both genders of aged MIPbeta1KO mice . - pubmed

Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection . - pubmed

Examination of NLRP3 inflammasome expression illustrated decreased NLRP3 mRNA expression and decreased IL1beta production in aged lung in response to secondary S. pneumoniae infection . - pubmed

Long noncoding RNA LINC01510 promotes the growth of colorectal cancer cells by modulating MET expression . - pubmed

Long intergenic non - protein coding RNA 1510 , an enhancer lncRNA ( LINC01510 ) , a lncRNA enhancer is upregulated in colorectal cancer ( CRC ) , and its expression might relate to MET as revealed by lncRNA microarray data . - pubmed

Results : In the present study , we found that LINC01510 was significantly upregulated in CRC tissues and cell lines . - pubmed

Meanwhile , gain- and loss - of - function assays demonstrated that LINC01510 overexpression increased CRC cell proliferation , and promoted cell cycle progression from the G1 phase to the S phase . - pubmed

Conclusions : Taken together , our findings suggested that upregulation of LINC01510 contributes to the proliferation of CRC cells , at least in part , through the regulation of MET protein . - pubmed

Increased follicular atresia was evident in NeurARKO ovaries with a 4 - fold increase in unhealthy large preantral follicles ( p & lt ; 0.01 ) . - pubmed

[ Effects of peroxisome proliferator - activated receptor gamma - toll - like receptor 4 - tumor necrosis factor - alpha targeted pathway on hyperglycemia induced myocardium inflammation and oxidative stress ] . - pubmed

OBJECTIVE : To investigate the potential effects and mechanism on peroxisome proliferator - activated receptor gamma - toll - like receptor 4 - tumor necrosis factor - alpha ( PPARgamma - TLR4 - TNF - alpha ) targeted pathway on hyperglycemia induced myocardium inflammation and oxidative stress . - pubmed

CONCLUSIONS : 4 mgxkg-1xd-1 pioglitazone could activate PPARgamma - TLR4 - TNF - alpha targeted pathway , thus inhibit inflammatory and oxidative stress factors expression , and down - regulate hyperglycemia induced myocardium inflammatory and oxidative stress level , but the effect did not show a dose dependent manner . - pubmed

Oxidative stress and NF - kappaB signaling are involved in LPS induced pulmonary dysplasia in chick embryos . - pubmed

LPS treatment also resulted in reduced CAV-1 expression and up - regulation of Collagen I , suggesting increased lung fibrosis , which was verified by Masson staining . - pubmed

Background : Bevacizumab is a recombinant humanised monoclonal antibody to vascular endothelial growth factor shown to improve survival in advanced solid cancers . - pubmed

Forty four percent of 682 melanomas assessed had a BRAFV600 mutation . - pubmed

[ PD - L1 - Mediated Immune Escape Mechanism of Cancer Stem - Like Cells ] . - pubmed

In this review article , we summarize the expression of PD - L1 , a molecular target of ICIs , in CSCs , and discuss the possibility of CSC - targeting immunotherapy using ICIs . - pubmed

Here , we investigated kidney function of a novel gene associated with nephronophthisis , CEP164 , coding a centriolar distal appendage protein , using a Cep164 knockout mouse model . - pubmed

Immunotherapy with T cells expressing chimeric antigen receptors ( CAR ) is an emerging and promising treatment against refractory cancers . - pubmed

Factors Associated with the Need for Insulin as a Complementary Treatment to Metformin in Gestational Diabetes Mellitus . - pubmed

OBJECTIVE : To evaluate the factors associated with the need for insulin as a complementary treatment to metformin in pregnant women with gestational diabetes mellitus ( GDM ) . - pubmed

CONCLUSION : Obesity resulted in an increased chance of the mother needing insulin as a complementary treatment to metformin , while FG & lt ; 90 mg / dL and primiparity were protective factors . - pubmed

Early outcomes with utilization of tissue plasminogen activator in COVID-19 - associated respiratory distress : A series of five cases . - pubmed

The anti - proliferative activity of ursolic acid in MDA - MB-231 human breast cancer cells through Nrf2 pathway regulation . - pubmed

The potential mechanisms of action of ursolic acid ( UA ) in regulating cell proliferation in MDA - MB-231 human breast cancer cells through Nrf2 pathway were investigated . - pubmed

There were 15 subjects with MAPT H1 / H1 and 11 subjects with MAPT H1 / H2 within PD - MCI , and 33 subjects with MAPT H1 / H1 and 19 subjects with MAPT H1 / H2 within all PD . - pubmed

Further , the subgroup of PD patients carrying the risky MAPT H1 / H1 haplotype was compared with noncarriers ( MAPT H1 / H2 haplotype ) in terms of CBF by a two - sample t test . - pubmed

Additionally , the PD patients with MAPT H1 / H1 haplotype had decreased perfusion than the ones with H1 / H2 haplotype at the posterior areas of the visual network ( VN ) , default mode network ( DMN ) , and dorsal attention network ( DAN ) . - pubmed

Targeting IL-1beta in the Treatment of Atherosclerosis . - pubmed

Compared with other cytokines , interleukin-1beta ( IL-1beta ) is associated with acute and chronic inflammation . - pubmed

The results of CANTOS suggested an important role of IL-1beta in atherosclerosis . - pubmed

We herein discussed the important immunomodulatory effect IL-1beta exerts on atherosclerosis and the potential mechanisms underlying it . - pubmed

We also reviewed bench - to - bedside clinical translation of IL-1beta neutralizing strategies associated with the use of IL-1beta blockade in patients with atherosclerosis . - pubmed

This significantly contributed to the pathogenesis in AAA , whereas overactive Transforming growth factor - beta played a major role in the pathogenesis of TAA . - pubmed

The allelic frequencies at 6 isozyme loci ( Es-1 , Es-2 , Es-3 , Es-4 , Es - Si and Amy-1 ) were examined in 4 outbred Wistar strains and additionally 2 SD strains as controls . - pubmed

The possible roles for phospholipases in lamellar body development and in the respiratory distress syndrome of the newborn are discussed . - pubmed

Plasma elastase levels were estimated in 190 patients of both sexes above the age of 65 with the exception of one male subject with prostatic carcinoma who was 51 years of age . - pubmed

Human rotavirus strain Ro1845 , which was isolated in 1985 from an Israeli child with diarrhea , has a hemagglutinin that is capable of agglutinating erythrocytes from guinea pigs , sheep , chickens , and humans ( group O ) . - pubmed

Patients with a diagnostic biopsy , as compared to patients with a nondiagnostic biopsy , had a statistically significant increase in the frequency of having AIDS diagnosed before the biopsy , longer duration of AIDS ( in patients with AIDS diagnosed before the biopsy ) , greater number of different prior opportunistic infections , and a more elevated serum alkaline phosphatase level . - pubmed

In particular , the 15 patients with hepatic mycobacterial infection , as compared to the other patients , had a statistically significant increase in the frequency of having AIDS diagnosed prior to the biopsy , longer duration of AIDS , more frequent prior opportunistic infections , more severe leukopenia , and a more elevated serum alkaline phosphatase level . - pubmed

[ A study on serum creatine phosphokinase and type A behavior in schizophrenia ] . - pubmed

The CPK levels of 79 patients with schizophrenia ( 36 males and 43 females and 88 normal control subjects ( 53 males and 35 females ) were assessed . - pubmed

The result shows that the CPK level of the patients with acute schizophrenia ( 307.33 Iu / L ) was significantly higher than that of the normal control subjects ( 160.51 Iu / L ) ( t = 3.534 , N21 , 88 , P less than 0.01 ) and the CPK level of male schizophrerines rose more significantly . - pubmed

Association between DR antigens and the occurrence of cytotoxic alloantibodies was studied in 251 patients on dialysis . - pubmed

Leucocyte superoxide dismutase levels in acute and chronic leukemias . - pubmed

Superoxide dismutase " SOD " enzyme levels in leucocytes of patients with acute and chronic leukemia , were measured by using Misra and Fridovich 's epinephrine method . - pubmed

In all types of leukemia , the SOD levels were found to be significantly higher than normals . - pubmed

No relationship was found between the SOD level and types of leukemia . - pubmed

Nine of ten SLE patients exhibited significant impairment of IgG suppression but no correlation was found between the outcome of the IgG suppressor cell assay and disease activity or the treatment protocol applied . - pubmed

By means of ultrasonography , arterial wall stiffness , arterial wall thickness , and the elastic modulus of the common femoral artery were estimated in a group of 19 young insulin - dependent diabetics . - pubmed

We suggest that urokinase , presumably released by the activated proliferating histiocytes , may play a major role in the extracellular matrix degradation leading to erosion of cartilage and adjacent bone in multicentric reticulohistiocytosis . - pubmed

Nippostrongylus brasiliensis - induced depression of heterologous immune responses : effects of the histamine H2 receptor antagonist , cimetidine . - pubmed

Intravascular coagulation and plasma fibrinogen in pregnancy . - pubmed

Rehydration as a diagnostic and therapeutic measure in hypercalcemia including an assessment of the calcium - lowering effect of porcine calcitonin . - pubmed

[ Cryoglobulinemia with gamma 1A , gamma 1 M multiple paraproteinemia ] . - pubmed

We conclude that bromocriptine , given to patients with polycystic ovarian disease , inhibits LH hypersecretion , leading to restoration of cyclic ovarian function and reduced androgen synthesis . - pubmed

In vitro stimulated peripheral blood lymphocytes from multiple sclerosis patients produce idiotypes of oligoclonal CSF IgG. - pubmed

Anti - idiotypic ( anti - Id ) antisera prepared against IgG from the cerebrospinal fluid of patients with multiple sclerosis were used to analyze culture supernatants of in vitro stimulated peripheral blood lymphocytes ( PBL ) from the patients . - pubmed

This finding provides additional evidence that the production of oligoclonal IgG in multiple sclerosis is not exclusively a feature of the central nervous system , but is also a systemic immunologic phenomenon . - pubmed

It is concluded that female rats are less susceptible to CCl4 - -alcohol - induced liver damage , especially hydroxyproline accumulation , which is explained by the known fact that females are more resistant against CCL4 - hepatotoxicity as a consequence of a minor role of bioactivation in the metabolic degradation of CCL4 by females . - pubmed

After injection of the antibodies in rats , diffuse granular deposits of rabbit IgG , typical of passive Heymann nephritis , were detected along the glomerular capillary walls . - pubmed

These antigens are major glycoproteins of the BB membranes and appear to be associated with the nephritogenic antigens of passive Heymann nephritis . - pubmed

Integrated regulation of very low density lipoprotein triglyceride and apolipoprotein - B kinetics in non - insulin - dependent diabetes mellitus . - pubmed

Turnover rates of plasma very low density lipoprotein ( VLDL ) triglyceride ( TG ) and apolipoprotein - B ( apo - B ) were significantly increased in age- and weight - matched groups of normolipemic and hyperlipemic mild diabetics , and hyperlipemic moderately severe diabetics when compared with normolipemic controls . - pubmed

As in the normolipemic subjects , a significant correlation between VLDL TG and apo - B turnover rates was found in all diabetic groups , suggesting that integration of TG and apo - B production at synthetic and/or secretory sites is retained in diabetes , thus resulting in increased secretion of VLDL particles of normal composition . - pubmed

In normolipemic mild diabetic subjects , the fractional turnover rates of VLDL TG and apo - B were also significantly increased so that increased removal accompanied increased VLDL production . - pubmed

In the hyperlipemic diabetics , however , the fractional turnover rates were significantly reduced , hence the increased in VLDL removal was not sufficient to compensate for enhanced production . - pubmed

In normolipemic mild diabetic patients , low density lipoprotein ( LDL ) formation was increased , only a small fraction of VLDL apo - B being removed via a non - LDL pathway , presumably as remnant VLDL . - pubmed

In hyperlipemic mild diabetics , removal of VLDL apo - B via both the LDL and non - LDL pathways was increased . - pubmed

In hyperlipemic moderately severe diabetes , LDL formation was not increased ; catabolism of VLDL apo - B through the non - LDL route was however , fivefold greater than normal . - pubmed

We conclude that increased VLDL secretion is a fundamental defect in non - insulin - dependent diabetes . - pubmed

The increase in LDL and/or VLDL remnant formation , regardless of prevailing plasma lipid levels or the severity of diabetes , provides a source of cholesterol which may account for the atherogeneity of this disorder . - pubmed

STUDY OBJECTIVES : To measure interleukin-1 beta ( IL-1 beta ) levels in pleural effusions of different etiologies and their relationship with several pleural inflammatory parameters , and to verify whether IL-1 beta can be used as diagnostic marker in the differential diagnosis of pleural diseases . - pubmed

RESULTS : IL-1 beta was above 200 pg / mL in all the patients with empyema but only in three patients with other etiologies . - pubmed

As a diagnostic criterion for empyema , pleural IL-1 beta concentration greater than 200 pg / mL had a sensitivity of 100 % , a specificity of 96 % , and a positive and negative predictive value of 0.82 and 1 , respectively . - pubmed

CONCLUSIONS : Our data suggest that IL-1 beta has a significant role in pyogenic infections of the pleural space but not in effusions of other etiologies . - pubmed

Increased hypoxia has been found after beta 2 adrenoceptor agonists ( but not adrenaline ) in asthmatics . - pubmed

An RNA polymerase I core promoter binding factor ( CPBF ) was purified to apparent homogeneity from rat adenocarcinoma ascites cells by chromatographic fractionation on a series of columns including an oligodeoxynucleotide affinity column . - pubmed

Interferons ( IFNs ) are families of cytokines which have been discovered and extensively characterized in the context of host defense against viral infections . - pubmed

We describe a PCR - based assay for determining c - erbB-2 oncogene amplification in breast cancer in which we use the TaqMan system . - pubmed

This homogeneous assay is time - saving , avoids usually cumbersome postamplification procedures ( that can be additional sources of inaccuracy and contamination ) , and seems suitable for determination of c - erbB-2 oncogene amplification in tumor specimens . - pubmed

Treatment of chronic hepatitis C with interferon - alpha . - pubmed

OBJECTIVE : to identify pretreatment predictive factors of long - term biochemical and virological response to interferon - alpha in chronic hepatitis C and to determine the effects of a second course of interferon - alpha in patients who responded but relapsed after interferon withdrawal . - pubmed

PATIENTS : 112 patients with chronic hepatitis C were treated with recombinant interferon - alpha ( 3 MU three times a week for 6 months ) . - pubmed

We found : ( a ) a point mutation and loss of the specific activity of the tumor suppressor gene p53 without alteration of the apoptotic response to transforming growth factor beta1 ; ( b ) a gradual decrease of retinoblastoma protein , which was constantly present , mainly in a hyperphosphorylated form ; and ( c ) an increase of cyclin - dependent kinase inhibitor p27 expression in confluent differentiating cells , as expected , whereas , surprisingly , a disappearance of the p21 protein was observed in parallel . - pubmed

Detection of circulating cancer cells by nested reverse transcription - polymerase chain reaction of cytokeratin-19 ( K19)--possible clinical significance in advanced gastric cancer . - pubmed

Intermediate filament cytokeratin-19 ( K19 ) protein is expressed in normal and malignant gastrointestinal epithelial cells , but not in peripheral blood ( PB ) . - pubmed

Small amount of circulating gastric cancer cells can be detected by a sensitive nested reverse transcription - polymerase chain reaction ( RTPCR ) with primers specific for K19 mRNA . - pubmed

None of the other pertinent clinicopathological features , including the disease extent and the histopathologic types of the tumors , were related to the expression of K19 in PB . - pubmed

However , the survival impact of K19 was less significant in the other 17 patients whose tumors had responded to systemic chemotherapy . - pubmed

We concluded that detecting circulating cancer cells by K19 nested RT - PCR is associated with poor prognosis of gastric cancer , particularly in those patients who are not responsive to systemic chemotherapy . - pubmed

Evidence that an HLA - DQA1 - DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection - related aetiology . - pubmed

Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia ( c - ALL ) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1 * 0101/*0104 and DQB1 * 0501 than appropriate control subjects . - pubmed

Levodopa induces a cytoplasmic localization of D1 dopamine receptors in striatal neurons in Parkinson ' s disease . - pubmed

Mutations in the CNGB3 gene encoding the beta - subunit of the cone photoreceptor cGMP - gated channel are responsible for achromatopsia ( ACHM3 ) linked to chromosome 8q21 . - pubmed

While mutations in the CNGA3 gene on chromosome 2q11 are responsible for achromatopsia in a subset of patients , previous linkage studies have localized another achromatopsia locus , ACHM3 , on chromosome 8q21 . - pubmed

Using achromatopsia families in which CNGA3 mutations have been excluded , we refined the ACHM3 locus to a 3.7 cM region enclosed by markers D8S1838 and D8S273 . - pubmed

In this study , we performed immunostaining for CK , EMA , HBME , CD57 and CD15 in PTC , and benign thyroid nodular lesions to compare the sensitivity and the specificity of these antisera for PTC . - pubmed

Fifty - five PTC ( composed of 30 papillary variants and 25 follicular variants ) , 5 follicular carcinomas , 30 follicular adenomas , and 20 thyroid nodular lesions ( 5 papillary variants and 15 follicular variants ) were submitted for immunostaining with CK , EMA , HBME , CD57 , and CD15 . - pubmed

CK and HBME showed the highest sensitivity and specificity for PTC when an arbitrary cutoff of more than 10 % positive cells was considered as positive diagnostic immunostaining for these sera . - pubmed

One case of PTC showed negative HBME but positive CD15 , whereas three papillary variants and two follicular variants of benign thyroid nodules revealed a positive diagnostic HBME immunostaining for PTC and negative CK immunostaining . - pubmed

Any combination of positive diagnostic immunostaining with CK+ HBME , CK+ CD57 or CK+ CD15 has a sensitivity of 95 % and specificity of 90 % for PTC . - pubmed

Three of five follicular carcinomas showed negative reactivity for HBME , CD57 , and CD15 . - pubmed

A combination of immunostaining with CK , HBME and CD57 ( or CD15 ) is a sensitive and specific test for PTC . - pubmed

Effects of growth hormone treatment on red cell plasma membrane fatty acid constituents in hypopituitary adults . - pubmed

The effects of replacement with recombinant human GH ( hGH ) on red cell plasma membrane fatty acid and cholesterol constituents were assessed in nine adult patients with growth hormone deficiency . - pubmed

NF - kappa B does not modulate sensitivity of renal carcinoma cells to TNF alpha - related apoptosis - inducing ligand ( TRAIL ) . - pubmed

BACKGROUND : Immune cells express TNF - related apoptosis - inducing ligand ( TRAIL ) and may play an important role in controlling the growth of renal cancer . - pubmed

RESULTS : Two RCC lines were highly sensitive to TRAIL - induced cell death , two were of intermediate sensitivity , and two were insensitive . - pubmed

CONCLUSIONS : NF - kappa B , although stimulated in these cell lines , does not play a role in the sensitivity of RCC to TRAIL and could play other functions in TRAIL signaling . - pubmed

Genomic characterization of human SEC14L1 splice variants within a 17q25 candidate tumor suppressor gene region and identification of an unrelated embedded expressed sequence tag . - pubmed

We more precisely mapped SEC14L1 within a discrete region of 17q25 that likely harbors at least one putative breast and ovarian tumor suppressor gene . - pubmed

As retinoids have been shown to inhibit the growth of breast cancer cells , loss of the proposed SEC14L1 retinal - binding function may contribute to breast tumorigenesis . - pubmed

As TTPA and CRALBP have been implicated in retinitis pigmentosa ( RP ) , altered SEC14L1 expression may contribute to RP in previously unlinked families . - pubmed

Recessively inherited mutations in the HFE gene are responsible for iron accumulation in most cases of hereditary haemochromatosis and may have a role in HCV infection . - pubmed

AIMS : To assess the prevalence of HFE mutations in Scottish HCV infected patients and to explore the effect of the carrier state on serum and liver iron stores , and the severity of liver disease . - pubmed

Carriage of HFE mutations , although frequently observed in these HCV infected patients , does not have a role in the accumulation of iron or the progression of liver disease in HCV infection . - pubmed

Expression of BLM ( the causative gene for Bloom syndrome ) and screening of Bloom syndrome . - pubmed

The causative gene for BS is the BLM gene which encodes the BLM RecQ helicase protein . - pubmed

The detection of BLM gene mutations for laboratory diagnosis of BS is laborious and impractical , unless there are common mutations in a population . - pubmed

The BLM protein was not detected in EBV - transformed lymphoblasts from three BS patients . - pubmed

However , in lymphoblasts from BS patients no nuclear dots of the BLM protein were detected . - pubmed

The expression of beta2 - adrenergic receptors ( beta2 - R ) on B lymphocytes and agonist - induced cAMP production is reduced in patients with rheumatoid arthritis ( RA ) . - pubmed

To further study functional consequences of the diminished beta2 - R density on B lymphocytes in RA patients , agonist - induced cell death was evaluated and compared to healthy controls . - pubmed

B lymphocytes from patients with RA and healthy controls were activated with anti - IgM - antibody . - pubmed

Apoptotic and necrotic cells were determined using Annexin - V and propidium - iodide staining . - pubmed

However , in RA patients the increase in cell death following beta2 - R stimulation ( 21.8 + /- 8.9 % ) was significantly impaired ( p = 0.02 ) . - pubmed

Our data demonstrate that catecholamine - induced cell death after stimulation of beta2 - R on B lymphocytes is decreased in RA patients , possibly contributing to the pathogenesis of the disease . - pubmed

To identify inhibitors of the intrinsic N - acetylated alpha - linked acidic dipeptidase ( NAALADase ) activity of prostate specific membrane antigen ( PSMA ) that may be useful for targeting imaging agents or chemotherapeutic drugs to disseminated prostate cancer , analogs of the tetrahedral transition state for hydrolysis of the natural substrate , N - acetylaspartylglutamate ( NAAG ) , were synthesized . - pubmed

Mutations in the Recql4 gene are very likely responsible for a subset of Rothmund - Thomson syndrome ( RTS ) cases , but until now there has been no animal model to confirm this . - pubmed

Knockout mice in which the Recql4 gene is disrupted at exons 5 - 8 exhibit embryonic lethality at embryonic day 3.5 - 6.5 . - pubmed

The exon 13 - deleted Recql4 - deficient mice are viable , but exhibit severe growth retardation and abnormalities in several tissues , and embryonic fibroblasts show a defect in cell proliferation . - pubmed

Abnormalities in the Recql4 - deficient mice are similar to those in RTS patients , suggesting that defects in the Recql4 gene may indeed be responsible for RTS . - pubmed

CD14 - positive cells cultured in the presence of PSK significantly increased the expression of HLA class II antigen and CD40 ; significantly increased the number and expression of CD80- , CD86- and CD83 - positive cells ; decreased Fluorescein isothiocyanate ( FITC)-dextran uptake , augmented IL-12 production ; augmented the allogeneic mixed lymphocyte reaction ; and induced antigen - specific cytotoxicity . - pubmed

To date there have been limited studies of HSA21 gene expression in trisomy 21 conceptuses . - pubmed

Since non - HSA21 antioxidant genes are reported to be concomitantly upregulated in certain DS tissues , we examined the expression of glutathione peroxidase-1 ( GPX1 ) in control and DS fetal organs . - pubmed

Interestingly , GPX1 expression was unchanged in the majority of DS organs and decreased in DS livers . - pubmed

The diagnosis and treatment of prostate cancer have been dramatically improved due to the development of PSA screening , transrectal ultrasonography and new anti - androgen drugs , such as LH - RH analog , with fewer side effects . - pubmed

In the present study , we provide evidence that the hypertrophic agonist , phenylephrine ( PE ) , promotes phosphorylation of CREB in adult rat cardiac myocytes through alpha ( 1 )- and beta - adrenergic receptors . - pubmed

The same pathways seem to regulate atrial natriuretic peptide ( ANF ) mRNA expression , a highly conserved marker gene of cardiac hypertrophy , suggesting that the PE - stimulated activation of CREB is likely to play an important role in the hypertrophic response . - pubmed

with the breast cancer cells and syngeneic / allogeneic - transfected fibroblasts modified to secrete IL-2 survived significantly longer ( P & lt ; .005 ) than mice in various control groups , including mice injected i.c . - pubmed

Botulinum toxin A for treatment of neurogenic detrusor overactivity and incontinence in patients with spinal cord lesions . - pubmed

OBJECTIVE : To evaluate the efficacy of intravesical botulinum toxin A ( BTA ) in the treatment of severe neurogenic detrusor overactivity ( NDO ) with incontinence in patients with spinal cord lesions ( SCLs ) . - pubmed

Curcumin blocks HIV protease inhibitor ritonavir - induced vascular dysfunction in porcine coronary arteries . - pubmed

BACKGROUND : HIV protease inhibitor ritonavir ( RTV ) is associated with many cardiovascular complications and causes vascular dysfunction through oxidative stress . - pubmed

[ PPARgamma and colon cancer ] . - pubmed

Leptin as a common link to obesity and hypertension . - pubmed

While the relevance of endogenous leptin needs further clarification , it appears to be a potential pressure- and volume - regulating factor , and may function pathophysiologically as a common link to obesity and hypertension . - pubmed

The association with HLA - B27 is less strong in IBD - associated AS than in idiopathic AS , and there is evidence for an association between gut inflammation in AS with the Crohn 's - disease - related CARD15 mutations . - pubmed

Major advances have been made in recent years with the establishment of anti - tumour necrosis factor ( TNF ) therapy in AS , the other spondyloarthritides and IBD . - pubmed

Anti - TNF agents are of particular relevance to AS patients with concomitant IBD who are at risk of exacerbation of the underlying bowel disease when treated with NSAIDs . - pubmed

Plasma retinol - binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes . - pubmed

Retinol - binding protein-4 ( RBP4 ) , a new adipokine , was recently reported to provide a link between obesity and insulin resistance . - pubmed

RESEARCH DESIGN AND METHODS : An enzyme - linked immunosorbent assay was developed to measure human RBP4 plasma concentrations , which were then compared with various parameters related to insulin resistance in subjects with normal glucose tolerance ( NGT ; n = 57 ) , impaired glucose tolerance ( IGT ; n = 48 ) , and type 2 diabetes ( n = 49 ) . - pubmed

RESULTS : Plasma RBP4 concentrations were higher in the IGT and type 2 diabetic groups than in the NGT group ( median 18.9 [ range 11.2 - 45.8 ] , 20.9 [ 9.9 - 48.5 ] , and 18.1 microg / ml [ 9.3 - 30.5 ] , respectively ) . - pubmed

However , no difference was found between plasma RBP4 concentrations in the IGT and type 2 diabetic groups . - pubmed

Plasma RBP4 concentrations were found to be associated with sex , waist circumference , fasting plasma glucose , and insulin resistance . - pubmed

CONCLUSIONS : Plasma RBP4 concentrations were found to be elevated in subjects with IGT or type 2 diabetes and to be related to various clinical parameters known to be associated with insulin resistance . - pubmed

However , both MAPK and NF - kappaB are also stimulated by exercise , which promotes improvements in fuel homeostasis and can prevent skeletal muscle atrophy . - pubmed

RESULTS : Lipoatrophy was associated with higher triglycerides ( 330 vs 133 mg / dl , p = 0.0003 ) , lower HDL ( 33 vs 48 mg / dl , p = 0.02 ) , and a greater frequency of hypercholesterolemia ( total cholesterol & gt ; 200 mg / dl ; 64 % vs 23 % , p & lt ; 0.03 ) . - pubmed

Adiponectin was 53 % lower in patients with lipodystrophy ( 6.9 microg / ml vs 14.8 microg / ml , p = 0.005 ) , however there was no difference in the inflammatory markers soluble TNFa receptor 2 or interleukin 6 . - pubmed

[ Development of a novel ADAMTS13 activity assay for diagnosis of TMA and criteria for judgment of platelet transfusion ] . - pubmed

ADAMTS13 specifically cleaves unusually large von Willebrand factor ( VWF ) multimers , which induce platelet thrombi formation under high shear stress . - pubmed

The determination of plasma levels of ADAMTS13 activity is prerequisite for a differential diagnosis of thrombotic microangiopathies ( TMAs ) . - pubmed

The plasma antigen level of ADAMTS13 has generally good correlate to the plasma activity , but the several samples from acquired TTP patients with below 3 % activity showed apparently high antigen level from 5 to 30 % . - pubmed

[ Expression of focal adhesion kinase in cardiac myocytes of hypertrophic ventricle ] . - pubmed

OBJECTIVES : To investigate the role of focal adhesion kinase ( FAK ) in the pathogenesis of cardiac hypertrophy induced by hypertension . - pubmed

METHODS : Using immunofluorescent labeling , confocal microscopy and Western blotting , the expression and subcellular localization of FAK in the cardiac myocytes of left ventricle were determined in 2 , 6 , 12 , and 18 month - old rats with spontaneously hypertensive heart failure ( SHHF ) along with age - matched control Wistar - Kyoto ( WKY ) rats . - pubmed

CONCLUSIONS : FAK may play a role in the cell signaling transduction leading to cardiac hypertrophy , presumably through regulations of hypertrophic gene transcription and RNA processing . - pubmed

Pharmacological subversion of the S1P rheostat is proving to be clinically efficacious in multiple sclerosis , and both the scope and limitations of therapeutic modulation of the S1P axis in immunotherapy are becoming clearer as understanding of the integrated chemical physiology of the S1P system emerges . - pubmed

To avoid ovarian dysfunction , synthetic peptides corresponding to ZP glycoproteins have been proposed as candidate immunogens . - pubmed

CONCLUSION : The observed degree of coding sequence homology in LRP5 led us to expect that the baboon may serve as a useful model for future research into the role(s ) of this gene in primate metabolic diseases . - pubmed

While baseline learning and memory were unaffected by reduction of gamma2 containing GABA ( A ) receptors , ethanol dose - dependently impaired spatial memory equally in gamma2 heterozygous knockouts and wild type littermate controls . - pubmed

The conversion of the prion protein ( PrP ) from its cellular form , PrPC , to its pathogenic scrapie form , PrPSc , is a key event in neurodegenerative transmissible spongiform encephalopathies such as Creutzfeldt - Jakob disease ( CJD ) . - pubmed

One working hypothesis for TSE causation is that oligomeric forms of PrP are the proximate neurotoxic agents . - pubmed

To gain insights into these intermediates , we have studied PrP125 - 228 and its CJD - causing T183A variant in their monomer and dimer forms by means of coarse - grained protein molecular dynamics simulations . - pubmed

Neutrophil gelatinase - associated lipocalin ( NGAL ) in human neoplasias : a new protein enters the scene . - pubmed

The small 25 kDa peptide , neutrophil gelatinase - associated lipocalin ( NGAL ) , first known as an antibacterial factor of natural immunity , and an acute phase protein , is currently one of the most interesting and enigmatic proteins involved in the process of tumor development . - pubmed

The aim of the present review is to point out the main contradictory , sometimes even paradoxical , effects attributed to NGAL in human neoplasias . - pubmed

For instance , acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation , NGAL has a clear pro - tumoral effect , as has already been observed in different tumors ( e.g. - pubmed

Moreover , in thyroid carcinomas , NGAL is strongly induced by NF - kB , an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development . - pubmed

However , on the contrary , some studies have demonstrated that NGAL can inhibit the pro - neoplastic factor HIF-1alpha , FA - Kinase phosphorylation and also VEGF synthesis , thus suggesting that , in alternative conditions , NGAL also , paradoxically , has an anti - tumoral and anti - metastatic effect in neoplasias of , for example , the colon , ovary and pancreas . - pubmed

Because inheritance of the apoE4 allele is the strongest known genetic risk factor for Alzheimer disease , the reduced neuroprotection afforded by apoE4 - containing LpE might contribute to the neurodegeneration characteristic of this disease . - pubmed

However , a completely different mechanism may be operating in major depression , where the increased levels of glucocorticoid hormones are conceptualized as driven by an impairment in GR function ( glucocorticoid resistance ) , and therefore as a " compensatory " mechanism . - pubmed

{ alpha } 7 - nAChR - mediated suppression of hyperexcitability of colonic dorsal root ganglia neurons in experimental colitis . - pubmed

Overall , our findings suggest that nicotine at low 1 microM concentration suppresses in vitro hyperexcitability of inflamed colonic DRG neurons in a mouse model of acute colonic inflammation via activation of alpha ( 7 )- nAChRs . - pubmed

Changes in hormones , including testosterone , estrogen , cortisol , vasopressin , and prolactin , during the postpartum period in fathers may be biological risk factors in paternal PPD . - pubmed

We and others have previously shown that hyperactivation of the c - Kit pathway in an Nf1 haploinsufficient microenvironment is required for both tumor formation and progression . - pubmed

These studies identify the p21 ( Ras )- PI3 K pathway as a major regulator of the gain in Nf1(+/- ) mast cell degranulation in neurofibromas . - pubmed

Collectively , these studies identify both c - Kit and PI3 K as molecular targets that modulate mast cell functions in cases of NF1 . - pubmed

Previous studies of the association of the C17 T polymorphism of the mu opiate receptor gene with substance dependence compared cases with substance dependence to controls and usually found no significant association . - pubmed

Angiotensin - converting enzyme 2 is a key modulator of the renin - angiotensin system in cardiovascular and renal disease . - pubmed

RECENT FINDINGS : ACE2 deficiency is associated with elevated tissue and circulating levels of angiotensin II and reduced levels of angiotensin 1 - 7 . - pubmed

In atherosclerosis - prone apolipoprotein E knockout mice , ACE2 deficiency results in augmented vascular inflammation and an inflammatory response that contributes to increased atherosclerotic plaque formation . - pubmed

In the kidney , ACE2 deficiency is associated with progressive glomerulosclerosis . - pubmed

Interventions such as ACE2 replenishment or augmentation of its actions have proven successful in reducing hypertension , plaque accumulation , and renal and cardiac damage in a range of different models . - pubmed

SUMMARY : Repletion of ACE2 's activities offers a new strategy to complement current clinical interventions in treating hypertension , renal and cardiovascular disease . - pubmed

Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma . - pubmed

CONCLUSION : Matrix metalloproteinase ( MMP )- 20 is overexpressed in laryngeal squamous cell carcinoma ( LSCC ) compared with the adjacent normal laryngeal epithelium and MMP-20 plays a role in lymph node metastasis . - pubmed

All the findings indicate that MMP-20 may play a role in the initiation and progression of LSCC . - pubmed

OBJECTIVE : The MMPs are a gene family of zinc - dependent endopeptidases that have been implicated in tumor invasion and metastasis , and MMP-20 is a new member of the MMP family . - pubmed

The purpose of this study was to investigate whether MMP-20 is overexpressed in human LSCC and , if so , the significance of its overexpression in relation to clinical parameters . - pubmed

RESULTS : We found that MMP-20 is overexpresssed in LSCC compared with the adjacent normal laryngeal epithelium . - pubmed

Invariant NKT cells producing IL-4 or IL-10 , but not IFN - gamma , inhibit the Th1 response in experimental autoimmune encephalomyelitis , whereas none of these cells inhibits the Th17 response . - pubmed

Invariant NKT ( iNKT ) cells prevent EAE in an IL-4- , IL-10- , and IFN - gamma - dependent manner . - pubmed

However , which of the iNKT cell - produced cytokines regulates the Th1 or Th17 response in EAE remains unclear . - pubmed

Clinical scores for EAE , IL-17 , and IFN - gamma transcript levels , and IL-17- or IFN - gamma - expressing CD4(+ ) T cell percentages in the CNS and draining lymph nodes were higher in Jalpha18(-/- ) than in B6 mice , but all of these parameters in the CNS were reduced by the adoptive transfer of wild - type or IFN - gamma - deficient iNKT cells into the Jalpha18(-/- ) mice before immunization . - pubmed

Taken together , IL-4- and IL-10 - producing iNKT cells inhibit the Th1 cell response , but not the Th17 cell response , although wild - type iNKT cells suppress both the Th1 and Th17 responses in the CNS during EAE . - pubmed

Moreover , IFN - gamma - producing iNKT cells have a minimal role in the regulation of the Th1 and Th17 responses in EAE . - pubmed

Association of CYP19 gene polymorphism with vertebral fractures in Japanese postmenopausal women . - pubmed

We explored the relationship between CYP19 polymorphisms and vertebral fractures in postmenopausal Japanese women . - pubmed

The C allele rs2470152 was significantly associated with increased risk of vertebral fractures ( P = 0.04 ) , whereas none of the CYP19 polymorphisms showed differences in sex steroid levels between subjects with and without fractures . - pubmed

Allelic variants of aromatase genes appear to interact to influence the risk of vertebral fractures in postmenopausal Japanese women . - pubmed

Platelet adenosine diphosphate ( ADP ) receptor antagonists ( ticlopidine , clopidogrel , prasugrel , and ticagrelor ) are a major advance in the treatment of atherothrombotic diseases , especially acute coronary syndromes ( ACS ) . - pubmed

Endothelin B receptor agonist , IRL-1620 , provides long - term neuroprotection in cerebral ischemia in rats . - pubmed

We have earlier shown that stimulation of endothelin B receptors by IRL-1620 provides significant neuroprotection at 24h following cerebral ischemia . - pubmed

This study was designed to determine the effect of IRL-1620 on neurological functions , infarct volume , oxidative stress , and endothelin receptors following permanent middle cerebral artery occlusion for 7 days . - pubmed

No change in expression of endothelin A receptor was observed 7 days after induction of cerebral ischemia in vehicle or IRL-1620 treated rats . - pubmed

Selective endothelin B receptor activation may prove to be a novel therapeutic target in the treatment of cerebral ischemia . - pubmed

Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer . - pubmed

Activation of the fibroblast growth factor receptor pathway is a common event in many cancer types . - pubmed

Here we review the role of fibroblast growth factor receptor signalling in breast cancer , from SNPs in FGFR2 that influence breast cancer risk and SNPs in FGFR4 that associate with breast cancer prognosis , and potential therapeutic targets such as receptor amplification and aberrant autocrine and paracrine ligand expression . - pubmed

Apolipoprotein E regulation of myeloid cell plasticity in atherosclerosis . - pubmed

PURPOSE OF REVIEW : Apolipoprotein ( apo ) E is a multifunctional protein that has long been recognized for its ability to safeguard against atherosclerosis . - pubmed

Among its pleiotropic roles known to suppress atherosclerosis , mechanisms by which apoE regulates cells of the immune system have remained elusive . - pubmed

Because atherosclerosis is a chronic inflammatory disease that remains on the rise , understanding in more detail how apoE controls immune cell activation and function is of much interest . - pubmed

By promoting cellular cholesterol efflux in a cell autonomous manner and through its ability to enhance HDL function in hyperlipidemic plasma , apoE is now known to suppress atherosclerosis by controlling myeloid cell proliferation , monocyte activation and their capacity to infiltrate the vascular wall . - pubmed

Lastly , the structural basis for apoE isoform - specific effects in macrophage dysfunction and atherosclerosis susceptibility is beginning to emerge . - pubmed

SUMMARY : Collectively , these findings introduce a new dimension to our understanding of how apoE links lipoprotein biology to monocyte and macrophage function in atherosclerosis susceptibility . - pubmed

STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease , Sjogren ' s syndrome . - pubmed

Here we report that mice with T - cell - targeted deletion of Stromal Interaction Molecule ( STIM ) 1 and STIM2 [ double - knockout ( DKO ) ] mice develop spontaneous and severe pSS - like autoimmune disease , displaying major hallmarks of the disease . - pubmed

Sjogren ' s syndrome - specific autoantibodies ( SSA / Ro and SSB / La ) were detected in the serum , and progressive salivary gland destruction and loss of fluid secretion were also seen . - pubmed

Importantly , we report that peripheral blood mononuclear cells as well as lymphocytic infiltrates in submandibular glands from patients with pSS demonstrated significant reductions in STIM1 and STIM2 proteins . - pubmed

Thus , deficiency of STIM1 and STIM2 proteins in T cells , and consequent defects in Ca ( 2 + ) signaling , are associated with salivary gland autoimmunopathy in DKO mice and pSS patients . - pubmed

These data reveal a previously unreported link between STIM1 and STIM2 proteins and pSS . - pubmed

Curcumin reduces cisplatin - induced neurotoxicity in NGF - differentiated PC12 cells . - pubmed

We also investigated whether curcumin affects cisplatin effectiveness by analyzing the modulation of p53 gene expression and its effect on cisplatin cytotoxicity in HepG2 tumor cells . - pubmed

Curcumin neither suppressed p53 mRNA transcription nor protected tumor cells against cisplatin cytotoxicity . - pubmed

The cardiotoxicity of DOX formulations was evaluated by serum creatine kinase MB ( CKMB ) activity in both animal groups before and after drug administration . - pubmed

Mutations in STT3A and STT3B cause two congenital disorders of glycosylation . - pubmed

We describe two unreported types of congenital disorders of glycosylation ( CDG ) which are caused by mutations in different isoforms of the catalytic subunit of the oligosaccharyltransferase ( OST ) . - pubmed

Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1 . - pubmed

Previous reports have associated GRHL2 with tumor progression . - pubmed

However , the biological role of GRHL2 in human colorectal cancer ( CRC ) has not been explored . - pubmed

We examined the expression of GRHL2 in 75 CRC samples , as well as the paired non - tumor tissues , by immunohistochemistry , qRT - PCR , and western blot analysis . - pubmed

We performed lentivirus - mediated shRNA transfection to knock down GRHL2 gene expression in HT29 and HCT116 CRC cells . - pubmed

Moreover , we transiently silenced ZEB1 expression in GRHL2 - knockdown CRC cells using specific shRNA , and then examined the effects on GRHL2 and E - cadherin expression , as well as cell proliferation . - pubmed

Herein , we demonstrated that enhanced GRHL2 expression was detected in CRC , and correlated with higher levels of Ki-67 staining , larger tumor size , and advanced clinical stage . - pubmed

Knocking down GRHL2 in HT29 and HCT116 CRC cells significantly inhibited cell proliferation by decreasing the number of cells in S phase and increasing that in the G 0 / G 1 phaseof the cell cycle . - pubmed

Collectively , our study has identified ZEB1 as a target of GRHL2 and suggested a reciprocal GRHL2 - ZEB1 repressive relationship , providing a novel mechanism through which proliferation may be modulated in CRC cells . - pubmed

KRT9 gene mutation as a reliable indicator in the prenatal molecular diagnosis of epidermolytic palmoplantar keratoderma . - pubmed

EPPK is generally caused by mutations of the KRT9 gene . - pubmed

More than 26 KRT9 gene mutations responsible for EPPK have been described ( Human Intermediate Filament Database , www.interfil.org ) , and many of these variants are located within the highly - conserved coil 1A region of the alpha - helical rod domain of keratin 9 . - pubmed

In the present study , we performed amniotic fluid - DNA - based prenatal testing for three at - risk pregnant EPPK women from three unrelated southern Chinese families who carried the KRT9 missense mutations p. Arg163Trp and p. Arg163Gln , and successfully helped two families to bear normal daughters . - pubmed

Toll - like receptors and cancer , particularly oral squamous cell carcinoma . - pubmed

Once activated , they initiate signaling pathways leading to the release of cytokines and chemokines , which recruit immune cells inducing further cytokine production , the production of angiogenic mediators and growth factors , all of which may influence tumor progression . - pubmed

This paper examines the actions of TLRs in carcinogenesis with particular emphasis on their role in oral squamous cell carcinoma . - pubmed

A great amount of factors are implicated in the pathogenesis of VVs , including changes in hydrostatic pressure , valvular incompetence , deep venous obstruction , ineffective function of calf muscle pump , biochemical and structural alterations of the vessel wall , extracellular matrix abnormalities , impaired balance between growth factors or cytokines , genetic alterations , and several other mechanisms . - pubmed

Amyloid - beta and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus . - pubmed

BACKGROUND : Amyloid - beta ( Abeta1 - 42 ) , total tau ( T - tau ) , and phosphorylated tau ( P - tau181 ) in the cerebrospinal fluid ( CSF ) are the most promising biomarkers of Alzheimer ' s disease ( AD ) . - pubmed

CONCLUSIONS : This is the first study to report ISF Abeta and tau levels in the human brain without significant brain injury . - pubmed

Peroxisome proliferator - activated receptor - gamma agonist inhibits the mammalian target of rapamycin signaling pathway and has a protective effect in a rat model of status epilepticus . - pubmed

Peroxisome proliferator - activated receptor gamma ( PPAR - gamma ) has a protective role in several neurological diseases . - pubmed

The present study investigated the effect of the PPAR - gamma agonist , pioglitazone , on the mammalian target of rapamycin ( mTOR ) signaling pathway in a rat model of pentylenetetrazol ( PTZ)-induced status epilepticus ( SE ) . - pubmed

First , the course of activation of the mTOR signaling pathway in PTZ - induced SE was examined to determine the time - point of peak activity , as reflected by phopshorylated ( p)-mTOR / mTOR and p - S6 / S6 ratios . - pubmed

The levels of the interleukin ( IL )- 1beta and IL-6 inflammatory cytokines were detected using ELISA , and neuronal loss was observed via Nissl staining . - pubmed

Compared with the vehicle treated - SE group , pretreatment with pioglitazone was associated with the loss of fewer neurons , lower levels of IL-1beta and IL-6 , and inhibition of the activation of the mTOR signaling pathway . - pubmed

Therefore , the mTOR signaling pathway was activated in the PTZ - induced SE rat model , and the PPAR - gamma agonist , pioglitazone , had a neuroprotective effect , by inhibiting activation of the mTOR pathway and preventing the increase in the levels of IL-1beta and IL-6 . - pubmed

Serum immunoglobulin G concentrations against hepatitis E were determined using the enzyme linked immunosorbent assay method . - pubmed

BACKGROUND : Adiponectin levels have been shown to be associated with colorectal cancer ( CRC ) . - pubmed

Therefore , we investigated the potential for a genetic association between T - cadherin and CRC risk . - pubmed

Study results revealed that rs3865188 in the 5 ' flanking region of the T - cadherin gene ( CDH13 ) was significantly associated with CRC ( p = 0.0474 ) . - pubmed

In addition , the interaction between CDH13 and the adiponectin gene ( APN ) for CRC risk was investigated using a logistic regression analysis . - pubmed

Furthermore , the plasma adiponectin level showed a correlation with the gene - gene interaction , and the group with the highest risk for CRC had the lowest adiponectin level ( median , 4.8 mug / mL for the TT / GG genotype vs.7.835 mug / mL for the AA / AA genotype , p = 0.0017 ) . - pubmed

CONCLUSIONS : The present study identified a new genetic factor for CRC risk and an interaction between CDH13 and APN in CRC risk . - pubmed

RESULTS : The results indicated that minocycline inhibited inflammation , decreased the expression of interleukin-1beta , tumor necrosis factor - alpha , and metalloproteinase - 9 , and squamous metaplasia features such as hyperproliferation and abnormal epidermal differentiation of conjunctival epithelium . - pubmed

Statistical analyses were performed using Plink and R. RESULTS : VKORC1 and CYP2C9 were the major genetic determinants of warfarin MWD and SMWD , with CYP4F2 having a smaller effect . - pubmed

Also , serum ferritin level was significantly higher in RAS patients ( p<0.008 ) . - pubmed

In the prenatal diagnosis of Gaucher disease ( GD ) , glucocerebrosidase ( GBA ) activity is measured with fetal cells , and gene analysis is performed when pathogenic mutations in GBA are identified in advance . - pubmed

Serum IgG and risk of exacerbations and hospitalizations in chronic obstructive pulmonary disease . - pubmed

Insulin therapy improves health outcomes in patients with CF . - pubmed

Family - based analysis of GGT1 and HNF1A gene polymorphisms in patients with polycystic ovary syndrome . - pubmed

Previous studies indicate that genes GGT1 and HNF1A may contribute to the abnormal glucose metabolism and altered lipid profile that are important clinical features of PCOS . - pubmed

In the current study , the correlation between polymorphisms in the GGT1 and HNF1A genes and PCOS was explored . - pubmed

A total of 310 family trios were studied and the transmission disequilibrium test ( TDT ) was used to assess the linkage between PCOS and three single - nucleotide polymorphisms ( SNP ) ( rs4820599 of GGT1 , rs7305618 and rs2393791 of HNF1A ) . - pubmed

None of the three SNP markers showed significant transmission disequilibrium in PCOS family trios ( rs4820599 : GGT1 gene , chi2 = 1.067 ; rs7305618 : HNF1A gene , chi2 = 0.013 ; rs2393791 : HNF1A gene , chi2 = 0.031 ) . - pubmed

In conclusion , no significant evidence supported a relationship between genes GGT1 and HNF1A and PCOS in the current family trios . - pubmed

Despite the very low quality of evidence , restoring normoxia in patients with hypoxia is recommended , and blood pressure lowering drugs and treating hyperglycaemia with insulin should be avoided . - pubmed

Our objective was to determine the rate of acromegaly comorbidities once hypersecretion of growth hormone is controlled . - pubmed

Our main outcome measures were the prevalence of major metabolic complications of acromegaly ( diabetes , hypertension , low - density lipoprotein cholesterol , triglycerides ) at diagnosis and last follow - up in comparison with French epidemiological data . - pubmed

We describe the performance of the VENTANA PD - L1 ( SP142 ) Assay in terms of specificity , sensitivity , and the ability to stain both tumor cells ( TC ) and tumor - infiltrating immune cells ( IC ) , in NSCLC and UC tissues . - pubmed

The reader precision , repeatability and intermediate precision , interlaboratory reproducibility , and the effectiveness of pathologist training on the assessment of PD - L1 staining on both TC and IC were evaluated . - pubmed

We detail the analytical validation of the VENTANA PD - L1 ( SP142 ) Assay for PD - L1 expression in NSCLC and UC tissues and show that the assay reliably evaluated staining on both TC and IC across multiple expression levels / clinical cut - offs . - pubmed

In addition , pathologists met the predefined training criteria ( & gt;=85.0 % overall percent agreement ) for the assessment of PD - L1 expression in NSCLC and UC tissues with an average overall percent agreement & gt;=95.0 % . - pubmed

Occludin protein expression in human cervical cancer and its association with patient 's clinical characteristics . - pubmed

Objective : The objective of the study was to investigate the expression of the tight junction protein occludin ( encoded by OCLN gene ) in human cervical cancer and its association with clinical features of patients . - pubmed

Immuno - histochemical assay was applied to examine the expression of occludin protein in 61 cervical cancer tissues and matched adjacent cancer normal tissues . - pubmed

Results : Occludin protein was mainly expressed in cell membranes and cytoplasm of both the cervical cancer cell and the normal cells . - pubmed

In cervical cancer tissues , the positive rate of occludin protein was 77.05 % ( 47/61 ) , whereas , in adjacent normal tissues of the cancer , the positive rate was 96.72 % ( 59/61 ) . - pubmed

Therefore , the positive rate of occludin in cervical cancer tissues was significantly lower than that of the adjacent cancer tissues ( P & lt ; 0.05 ) . - pubmed

Occludin protein expression level was not significantly correlated with the age ( P & gt ; 0.05 ) , tumor size ( P & gt ; 0.05 ) , International Federation of Gynecology and Obstetrics staging ( P & gt ; 0.05 ) , pathological grades ( P & gt ; 0.05 ) , and lymph node metastasis ( P & gt ; 0.05 ) of the patients . - pubmed

Conclusion : Occludin protein may contribute to the development of cervical cancer . - pubmed

Synthetic immunocortin in concentration ~ 10 - 9 M suppresses phagocytosis in peritoneal macrophages , ConA - dependent blast transformation of rat lymphocytes , exhibits ACTH - like neurotropic activity and was suggested as a potential drug for treatment of a multiple sclerosis ( MS ) . - pubmed

The attenuation of HIV-1 Tat - induced neurotoxicity by Salvianic acid A and Danshen granule . - pubmed

The neurotoxicity of HIV-1 Tat protein contributes significantly to the pathogenesis of HAND , and hence the attractive therapeutic strategies focusing on Tat - induced neurotoxicity are warranted . - pubmed

However , the protective effects of Salvianic acid A and Danshen granule on Tat - induced neurotoxicity remain unknown . - pubmed

In conclusion , this study demonstrated that Salvianic acid A and Danshen granule provides substantial neuroprotection against Tat - induced neurotoxicity , which may be new therapeutic agent in Tat induced HAND or neurodegenerative diseases . - pubmed

Intravenous tissue plasminogen activator for ischemic stroke in early pregnancy dosed by actual body weight . - pubmed

Methods : Here , we present a patient who received intravenous tissue plasminogen activator in the emergency department during her first trimester of pregnancy for the treatment of an acute ischemic stroke . - pubmed

Post tissue plasminogen activator imaging revealed recanalization of the vessel and the patient 's National Institutes of Health Stroke Scale was 0 . - pubmed

Conclusion : We present positive outcomes of a mother and fetus after receipt of intravenous tissue plasminogen activator using actual body weight during the first trimester of pregnancy for an acute ischemic stroke . - pubmed

Recently , damage to ER - mitochondria signaling involving disruption of the VAPB - PTPIP51 tethers has been linked to the pathogenic process in Parkinson ' s disease , fronto - temporal dementia ( FTD ) and related amyotrophic lateral sclerosis ( ALS ) . - pubmed

Loss of neuronal synaptic function is a key feature of Parkinson ' s disease and FTD / ALS but the roles that ER - mitochondria signaling and the VAPB - PTPIP51 tethers play in synaptic function are not known . - pubmed

Our results reveal a new role for the VAPB - PTPIP51 tethers in neurons and suggest that damage to ER - mitochondria signaling contributes to synaptic dysfunction in Parkinson ' s disease and FTD / ALS . - pubmed

Here , we demonstrate that a luciferase reporter assay , in combination with ChIP - qPCR , reliably separates pathogenic ZBTB24 missense variants in the context of immunodeficiency , centromeric instability , facial anomalies ( ICF ) syndrome from natural variants in healthy individuals and patients of other diseases . - pubmed

Application of our assay to two published ZBTB24 missense VUSs indicates that they are likely not to cause ICF2 syndrome . - pubmed

Furthermore , we show that rare gnomAD ZBTB24 missense variants in key residues of the C2H2 - ZF domain lead to a loss of function phenotype that resembles ICF2 , suggesting that these individuals are carriers of ICF syndrome . - pubmed

The loss of ARNT / HIF1beta in male pancreatic beta - cells is protective against high fat diet - induced diabetes . - pubmed

The transcription factor aryl hydrocarbon receptor nuclear translocator ( ARNT)/hypoxia - inducible factor ( HIF )- 1beta ( ARNT / HIF1beta ) plays a key role in maintaining beta - cell function and has been shown to be one of the most down regulated transcription factors in islets from type 2 diabetic patients . - pubmed

In order to gain a better understanding of the role of ARNT / HIF1beta in the development of diabetes , we placed control ( + /+/Cre ) and beta - cell specific ARNT / HIF1beta knockout ( fl / fl / Cre ) mice on a high fat ( HF ) diet . - pubmed

Overall , mice lacking ARNT / HIF1beta in beta - cells have altered lipid signalling in vivo and are resistant to a HF diets ability to induce diabetes . - pubmed

Long noncoding RNA GAS6 - AS2 sponges microRNA-493 , thereby enhancing the malignant characteristics of breast cancer cells via upregulation of FUT4 . - pubmed

Long noncoding RNA ( lncRNA ) GAS6 - AS2 serves as an oncogenic lncRNA in various types of human cancer . - pubmed

In this study , we attempted to examine the functions of GAS6 - AS2 in breast cancer ( BC ) and explore the potential mechanisms involved . - pubmed

Reverse - transcription quantitative PCR was carried out to determine GAS6 - AS2 expression in BC tissues and cell lines . - pubmed

Multiple functional experiments , including a Cell Counting Kit-8 assay , Transwell migration and invasion assays , and an in vivo nude - mouse xenograft experiment , were conducted to evaluate the effects of GAS6 - AS2 in BC cells . - pubmed

GAS6 - AS2 expression was high in BC tumors , manifesting a strong correlation with tumor size , lymph node metastasis , TNM stage , and shorter overall survival in patients with BC . - pubmed

A knockdown of GAS6 - AS2 restricted BC cell proliferation , migration , and invasion in vitro and retarded tumor growth in vivo . - pubmed

Either miR-493 inhibition or FUT4 upregulation abrogated the consequences of GAS6 - AS2 knockdown in BC cells . - pubmed

These results revealed that GAS6 - AS2 sponges miR-493 to enhance the malignant characteristics of BC in vitro and in vivo by increasing FUT4 expression . - pubmed

[ IgA vasculitis with massive hemorrhage from the jejunum after steroid administration ] . - pubmed

Administration of steroids or factor XIII is recommended for patients with severe abdominal pain refractory to conservative management . - pubmed

Our objective was to recruit patients with the OFD1 clinical phenotype without genetic confirmation , aiming to identify genetic variants in the OFD1 gene . - pubmed

CONCLUSIONS : These new genetic variants will add to the spectrum of known OFD1 mutations associated with the OFD1 disorder . - pubmed

Effect of Cinacalcet on the Redox Status of Albumin in Secondary Hyperparathyroidism Patients Receiving Hemodialysis . - pubmed

Cinacalcet is a calcimimetic that permits impaired endothelial functions to be recovered via inhibiting parathyroid hormone ( PTH ) production in SHPT patients . - pubmed

The purpose of this study was to examine the effect of cinacalcet on the redox state of human serum albumin ( HSA ) , a reliable marker for assessing endothelial oxidative damage in SHPT patients who were receiving hemodialysis . - pubmed

Moreover , the radical scavenging abilities of HSA that was isolated from SHPT patients were increased by cinacalcet , suggesting the recovery of the impaired vascular anti - oxidant ability . - pubmed

Interestingly , the oxidized albumin ratio in SHPT patients was significantly higher than that in hemodialysis patients . - pubmed

It therefore appears that PTH may induce oxidative stress in SHPT patients . - pubmed

The radiotherapy - induced tumors were five sarcomas , one of which was a well - differentiated angiosarcomatous vascular lesion with negative c - Myc ( benign lesion ) , and the remaining patient had basal cell carcinoma associated with radiotherapy . - pubmed

Recently , various studies have shown that angiotensin - converting enzyme 2 ( ACE2 ) acts as the " doorknob " that can be bound by the spike protein of severe acute respiratory syndrome coronavirus 2 ( SARS - CoV-2 ) , which conduces to its entrance to the host cells , and plays an important role in corona virus disease 2019 ( COVID-19 ) . - pubmed

6 - Hydroxyindole is an endogenous long - lasting OATP1B1 inhibitor elevated in renal failure patients . - pubmed

The hepatic uptake transporter organic anion transporting polypeptide ( OATP ) 1B1 is inhibited by some uremic toxins ; however , direct inhibition can only partially explain the delayed systemic elimination of substrate drugs in renal failure patients . - pubmed

Plasma concentration of 6 - hydroxyindole in renal failure patients increased as renal function decreased , but might be insufficient to exhibit potent OATP1B1 inhibition . - pubmed

In conclusion , 6 - hydroxyindole is an endogenous long - lasting OATP1B1 inhibitor with elevated plasma concentrations in renal failure patients . - pubmed

In conclusion , CTNNB1 mutations and a chr6 copy number loss are likely the causative mutations underlying the tumorigenesis of DT while the gene expression profiles may help to differentiate patients who would be good candidates for wait - and - see management and those who might benefit from additional systemic or radiation therapies . - pubmed

LncRNA PCAT1 Interacts with DKC1 to Regulate Proliferation , Invasion and Apoptosis in NSCLC Cells via the VEGF / AKT / Bcl2 / Caspase9 Pathway . - pubmed

The lncRNA prostate cancer associated transcript 1 ( PCAT1 ) has been involved in tumorigenesis of multiple malignant solid tumors , but it is largely unknown that what is the role of lncRNA - PCAT1 and how it functions in the progression of lung cancer . - pubmed

Herein , we observed that lncRNA PCAT1 expression was upregulated in both human NSCLC tissues and cell lines , which was determined by qualitative polymerase chain reaction analysis . - pubmed

The results showed that PCAT1 not only promoted NSCLC cell proliferation and invasion but also inhibited cell apoptosis . - pubmed

Then , RNA pull - down assays with biotinylated probes and transcripts both confirmed that PCAT1 directly bounds with DKC1 that could also promote NSCLC cell proliferation and invasion and inhibit cell apoptosis . - pubmed

Furthermore , PCAT1 and DKC1 activated the vascular endothelial growth factor ( VEGF)/protein kinase B ( AKT)/Bcl-2 / caspase9 pathway in NSCLC cells , and inhibition of epidermal growth factor receptor , AKT , or Bcl-2 could eliminate the effect of PCAT1 / DKC1 co - overexpression on NSCLC cell behaviors . - pubmed

In conclusion , lncRNA PCAT1 interacts with DKC1 to regulate proliferation , invasion , and apoptosis in NSCLC cells via the VEGF / AKT / Bcl-2 / caspase9 pathway . - pubmed

Use of AMH in the Differential Diagnosis of Anovulatory Disorders Including PCOS . - pubmed

Since the historical use of gonadotrophin and estradiol levels to define the different anovulatory disorders has shown some limitations , the use of other markers such as anti - mullerian hormone ( AMH ) has been proposed . - pubmed

This review addresses the role of AMH in the differential diagnosis of anovulatory disorders , especially focusing on its value in the prognostic characterization of their severity . - pubmed

Renal renin release in patients with essential arterial hypertension and with unilateral renal artery stenosis . - pubmed

Coexistence between CGRP and substance P ( SP ) occurs , SP being present in about one quarter of the CGRP - immunoreactive neurons and CGRP being localized in a little more than half of the SP - immunoreactive neurons . - pubmed

Expression of hepatic mRNAs for insulin - like growth factors - I and - II during the development of hypothyroid rats . - pubmed

In vivo effects of recombinant human interleukin 6 , alone or in combination with local irradiation , on tumor growth in Lewis lung carcinoma - bearing mice . - pubmed

Lewis lung carcinoma ( LLC )- bearing mice were used as a mouse model to evaluate effects of recombinant human ( rh ) interleukin ( IL ) 6 and local X - irradiation ( LR ) on the growth of primary tumors and lung metastases . - pubmed

with LLC tumor cells and then treated with rhIL-6 ( 100 ng / dose ) s.c . - pubmed

The size of the primary tumor and numbers of lung metastases were reduced by rhIL-6 . - pubmed

Prolonged survival time was observed only in tumor - bearing mice treated with rhIL-6 in combination with LR . - pubmed

These studies suggest that rhIL-6 may have therapeutic value in the treatment of certain malignancies , especially if used in combination with LR . - pubmed

Five tumors were studied with a polymerase chain - reaction assay designed to detect the E6 region of human papillomavirus types 16 and 18 . - pubmed

[ A high level of alkaline phosphatase in the blood serum is not a contraindication to embolization of the hepatic artery in malignant neoplasms of the liver ] . - pubmed

It was inferred that alkaline phosphatase activity is not indicative of extent of liver involvement by tumor . - pubmed

A study was made of the number of pulmonary endocrine cells , immunoreactive for gastrin - releasing peptide ( bombesin ) or calcitonin , in the terminal bronchioles of 39 cases of pulmonary vascular disease . - pubmed

Serum amylase , immunoreactive elastase ( IRE ) , carcinoembryonic antigen ( CEA ) , and carbohydrate antigen ( CA 19 - 9 ) were measured in 40 patients with pancreatic cancer . - pubmed

In pancreatic cancer , elevated values were observed for amylase in 30 % of the patients , for IRE in 70 % , for CEA in 28 % , and for CA 19 - 9 in 68 % . - pubmed

Elevated serum IRE was observed more frequently in head cancer and resectable cancer , whereas elevation in CA 19 - 9 occurred more often in body - tail cancer and unresectable cancer . - pubmed

Elevation of serum IRE tends to occur at earlier stages of pancreatic cancer . - pubmed

Renal interaction between sympathetic activity and ANP in rats with chronic ischaemic heart failure . - pubmed

The diuretic and natriuretic effects of r - alpha - ANP ( 99 - 126 ) were investigated in rats with chronic ischaemic heart failure ( IHF ) produced by left coronary artery ligation . - pubmed

Immunoglobulin isotypes of anti - HBc and anti - HBe and hepatitis B virus ( HBV ) DNA elimination in acute hepatitis B. - pubmed

Antibodies to hepatitis B core antigen ( anti - HBc ) and e antigen ( anti - HBe ) were assayed in 46 sera from ten patients with acute hepatitis B utilizing immunoglobulin class- and subclass - specific enzyme immunoassays ( EIAs ) . - pubmed

Co - incident N and K ras gene mutations in a case of AML , restricted to differing cell lineages . - pubmed

Peripheral blood from a patient with acute myeloid leukaemia ( AML ) of M5 FAB classification , was shown to have mutations to both the N and K ras genes . - pubmed

The K - ras mutation , however , was present in all fractions , suggesting it had occurred in a multi - potential stem cell representing an earlier stage in the generation of the leukaemia , or possibly an incidental background phenomenon . - pubmed

Autoantibody from a patient with systemic lupus erythematosus was used to label PCNA in cell suspensions after the cells had been fixed and permeabilized . - pubmed

Peritonitis incidence and in vitro bacterial opsonization has been shown to depend on IgG concentrations in the dialysate and on the ability of macrophages to produce fibronectin . - pubmed

In some CAPD patients a disturbance in lymphokine and monokine release may be responsible for the reduced ability of their macrophages to kill bacteria . - pubmed

With GVHD directed to class I H-2 differences , pretreating LN cells with anti - Lyt-2 MAb prevented mortality , whereas MAb specific for Ly-1 or L3T4 cell surface determinants caused severe mortality . - pubmed

These data imply that lethal GVHD directed to class I H-2 differences is mediated by L3T4- , Lyt-2 + cells ; this subset of T cells was shown previously to control GVHD directed to multiple minor histocompatibility antigens , i.e. - pubmed

With whole H-2 differences , GVHD appeared to be controlled largely but not exclusively by L3T4 + , Lyt-2 - T cells . - pubmed

With class II incompatibilities , depleting donor cells of L3T4 + T cells , either by pretreatment with anti - L3T4 MAb + C or by fluorescence activated cell sorter selection , greatly reduced but did not completely abolish GVHD . - pubmed

The prognostic application of HL - A and ABO typing in placental choriocarcinoma . - pubmed

A common link between the induction of leukemia by ( i ) fractionated doses of x - irradiation and ( ii ) radiation leukemia virus in mice may be established by the observation that the segment of chromosome 2 between the loci for the minor histocompatibility antigen H-30 and color coat agouti ( H-30 - A ) includes distinct loci involved in susceptibility to leukemogenesis induced by factors i and ii . - pubmed

The concept of atypical depression is reviewed and data comparing the clinical effects of monoamine oxidase inhibitors and tricyclic antidepressants are presented . - pubmed

Monoamine oxidase inhibitors are indicated for treatment of syndromes of panic and generalized anxiety with or without supervening atypical depression . - pubmed

We investigated the hemodynamics of the greater and lesser circulation in 35 patients with primary hypertension , as well as the effects of calcium - channel blockade , to test whether a common factor may account for the excessive vascular resistance in the two circuits and whether intracellular calcium concentration ( [ Ca++]i ) may be involved . - pubmed

Oestrogen receptors and metabolism of oestrone sulphate in human mammary carcinoma . - pubmed

Islet amyloid polypeptide and its N - terminal and C - terminal flanking peptides ' immunoreactivity in islet amyloid of diabetic patients . - pubmed

In three non - diabetic subjects , pancreatic islet cells were immunoreactive to anti - IAPP8 - 17 and anti - N - terminal and C - terminal flanking peptide antibodies and the reactivity was enhanced with formic acid pretreatment . - pubmed

In six type 2 diabetic subjects and a subject with type A insulin resistance , islet amyloid deposits were reactive to anti - IAPP8 - 17 antibody , but not to anti - N - terminal and C - terminal flanking peptide antibodies . - pubmed

Osteopontin expression is increased in the heritable cardiomyopathy of Syrian hamsters . - pubmed

BACKGROUND : Osteopontin , a noncollagenous matrix protein , is transiently expressed in the heart after experimental cardiac injury , but its expression in states of continuing cardiac remodeling is unknown . - pubmed

We evaluated osteopontin expression in the heritable cardiomyopathy of the Syrian hamster . - pubmed

Osteopontin mRNA was 12 - fold greater in cardiomyopathic hearts compared with normal controls ( 1.76 + /- 0.31 versus 0.14 + /- 0.04 arbitrary units normalized to GAPDH , mean + /- SEM , P & lt ; .05 ) . - pubmed

Osteopontin mRNA above background levels was not detected in sections from noncardiomyopathic hamster hearts but was readily detected in sections from cardiomyopathic hamsters , in which it originated in cells morphologically consistent with tissue macrophages . - pubmed

CONCLUSIONS : In the hamster , osteopontin is expressed in heritably cardiomyopathic hearts under conditions of chronic injury and repair , and the source of ostopontin message appears to be issue macrophage - like cells in foci of inflammation . - pubmed

This model could be used to evaluate the biological role of osteopontin in myocardial inflammation and remodeling . - pubmed

Growth stimulation of ferritin of human leukemia cells in vitro . - pubmed

Ferritin has been reported to inhibit the growth of some leukemia cells in serum - supplemented culture . - pubmed

Recently we have found that ferritin stimulates the proliferation of human acute myeloblastic leukemia cells HL-60 and erythroleukemia cells K-562 - T1 in serum - free medium . - pubmed

In this study , we examined the effect of ferritin against 14 human leukemia cell lines using human heart ferritin in serum - depleted culture medium . - pubmed

These results suggest that ferritin has dual functions ; it promotes the growth of leukemia cells with low concentrations of FCS , but suppresses their growth with high concentrations of FCS . - pubmed

Antibodies against CD4 + lymphocytes are frequently detectable in HIV - infected patients . - pubmed

The experiments revealed that 60 % of HIV - infected patients harbored anti - CD4 cell antibodies in their plasma . - pubmed

There was a significant reduction in serum insulin levels and glucose clearance rates without overt diabetes for 30 Gy and 35 Gy ( p & lt ; 0.05 ) . - pubmed

Nucleotide sequences of the central portion of gp120 , including the third hypervariable ( V3 ) loop , were obtained from lymphocytes cocultivated with SupT1 cells from 29 AIDS patients in Bangui , Central African Republic . - pubmed

Glutathione S - transferase in human esophageal carcinoma . - pubmed

The expression of human glutathione S - transferase - pi ( GST - pi ) in esophageal squamous cell carcinoma and in corresponding morphologically normal mucosa from 17 patients was examined by Northern blots , in situ hybridization and immunohistochemistry . - pubmed

Relative GST - pi expression ( tumor / mucosa ) ranged from 0.31 to 1.52 ( 0.821 + /- 0.40 : mean + /- SD ) , and only 6 out of 17 cases demonstrated increased GST - pi transcripts in tumor tissue over normal tissue . - pubmed

No significant correlation was observed between the amount or pattern of GST - pi expression by carcinomas and the clinicopathological findings in the cases . - pubmed

The marked expression of GST - pi by non - pathologic mucosa obtained from the patients with esophageal carcinoma suggests that GST - pi may be a marker of increased carcinogen exposure , but not necessarily a marker of developed human esophageal cancer . - pubmed

Increased plasma - soluble fibrin monomer levels in patients with disseminated intravascular coagulation . - pubmed

Plasma - soluble fibrin monomer ( SFM ) level in patients with disseminated intravascular coagulation ( DIC ) was significantly higher than the level in patients with pre - DIC or in non - DIC patients , and the level in patients with pre - DIC was significantly higher than that in non - DIC patients . - pubmed

There was no significant difference in plasma SFM levels among various diseases underlying DIC . - pubmed

Plasma SFM level in patients with good outcome was significantly decreased after treatment for DIC . - pubmed

Receiver operating characteristic analysis suggests that plasma SFM level could be the most useful marker for the diagnosis of both DIC and pre - DIC . - pubmed

Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington ' s disease . - pubmed

The delivery of ciliary neurotrophic factor ( CNTF ) to the central nervous system has recently been proposed as a potential means of halting or slowing the neural degeneration associated with Huntington ' s disease ( HD ) . - pubmed

The following set of experiments examined , in detail , the ability of human CNTF ( hCNTF ) to prevent the onset of behavioral dysfunction in a rodent model of HD . - pubmed

These results support the concepts that implants of polymer - encapsulated hCNTF - releasing cells can be used to protect striatal neurons from excitotoxic damage , produce extensive behavioral protection as a result of that neuronal sparing , and that this strategy may ultimately prove relevant for the treatment of HD . - pubmed

CONCLUSIONS : In non - metastatic osteosarcoma of the extremity , chemotherapy - induced tumor necrosis , the baseline LDH serum value and the use of HDMTX are significant predictive factors for DFS . - pubmed

Hypochromic red cells and reticulocyte haemglobin content as markers of iron - deficient erythropoiesis in patients undergoing chronic haemodialysis . - pubmed

BACKGROUND : In patients on chronic haemodialysis , because of a non - specific increase in serum ferritin , iron deficiency may be overlooked leading to failure of erythropoietin treatment . - pubmed

Transferrin saturation was also measured in a subset of 25 patients ; iron deficiency was defined as a transferrin saturation & lt ; 15 % . - pubmed

RESULTS : The diagnostic sensitivity and specificity of a reticulocyte haemoglobin content & lt ; 26 pg in detecting iron deficiency were 100 % and 73 % respectively , compared with 91 % and 54 % for a percentage of hypochromic red cells & gt ; 2.5 . - pubmed

CONCLUSIONS : The reticulocyte haemglobin content is superior to the percentage of hypochromic red cells in detecting iron deficiency in haemodialysis patients . - pubmed

Unusual features of this case of gliomatosis cerebri include involvement of the entire central neuraxis , correlation with pre - mortem lumbar puncture cytology , and a markedly elevated Ki-67 labeling index . - pubmed

The Brn-3a transcription factor plays a critical role in regulating human papilloma virus gene expression and determining the growth characteristics of cervical cancer cells . - pubmed

Moreover , Brn-3a is overexpressed approximately 300 - fold in cervical biopsies from women with cervical intra - epithelial neoplasia type 3 ( CIN3 ) compared with normal cervical material . - pubmed

To test the role of Brn-3a in cervical neoplasia we have manipulated its expression in cervical carcinoma - derived cell lines with or without endogenous HPV genes . - pubmed

MATERIALS AND METHODS : Human urothelial cells cultured from normal bladder specimens underwent immunohistochemical staining and cellular extracts were prepared for Electrophoretic Mobility Shift Assays ( EMSA ) , Western blot analyses , RNA isolation and Northern Blot analyses before and after stimulation with TNF - alpha , LPS , and dsRNA . - pubmed

Systemic hypothermia following spinal cord compression injury in the rat : axonal changes studied by beta - APP , ubiquitin , and PGP 9.5 immunohistochemistry . - pubmed

OBJECTIVES : The present study addresses the question as to whether systemic hypothermia has similar protective qualities following severe spinal cord compression trauma using beta - APP- , ubiquitin- , and PGP-9.5 - immunohistochemistry combined with the ABC complex method as markers to identify axonal changes . - pubmed

Hemodynamic abnormalities in the left atrial appendage in patients with paroxysmal atrial fibrillation , with special reference to albumin - contrast echocardiographic aspects . - pubmed

METHODS AND RESULTS : Transesophageal echocardiography with intravenous albumin - microspheres ( Albunex , 0.2 ml / kg ) was performed in 100 consecutive patients ( 44 patients in sinus rhythm without previous paroxysmal atrial fibrillation : 13 patients in sinus rhythm who had had previous episodes of paroxysmal atrial fibrillation ; and 43 patients with sustained atrial fibrillation ) . - pubmed

Using a refinement of a previously reported cell fusion complementation assay , the previously assigned Ddb+ xeroderma pigmentosum E strains , XP89TO , XP43TO , and XP24KO , with various phenotypes in DNA repair markers , were reassigned to xeroderma pigmentosum group F , xeroderma pigmentosum variant , and ultraviolet - sensitive syndrome , respectively . - pubmed

The Ddb - xeroderma pigmentosum E strains , XP82TO , and GM02415B , which showed almost normal cellular phenotypes in DNA repair markers , however , remained assigned to xeroderma pigmentosum group E. With the exception of the Ddb+ strain XP89TO , which demonstrated defective nucleotide excision repair , both Ddb- and Ddb+ xeroderma pigmentosum E cells exhibited the same levels of variation in unscheduled DNA synthesis that were seen in normal control cells . - pubmed

By genome DNA sequencing , the two Ddb - xeroderma pigmentosum E strains were shown to have mutations in the DDB2 gene , confirming previous reports for XP82TO and GM02415B , and validating the classification of both cells . - pubmed

As only the Ddb- strains investigated remain classified in the xeroderma pigmentosum E complementation group , it is feasible that only Ddb- cells are xeroderma pigmentosum E and that mutations in the DDB2 gene are solely responsible for the xeroderma pigmentosum E group . - pubmed

OBJECTIVE : In the present study , the frequency of ANT and its associations with collagen vascular and spinal disease have been investigated . - pubmed

Although patients produce antibody exuberantly , the immunopathogenesis involves cellular immunity -- notably , CD8(+ ) cytotoxic lymphocytes , multinucleate giant cell granulomas , and ultimately interstitial fibrosis . - pubmed

In typical cases , the history of a known exposure and the presence of a characteristic interstitial lung disease with serologic confirmation of IgG antibody to the offending antigen suffice for diagnosis . - pubmed

In vitro study of IL-8 and goblet cells : possible role of IL-8 in the aetiology of otitis media with effusion . - pubmed

These results suggest that : ( i ) goblet cells are target cells for the pro - inflammatory cytokines IL-1beta , TNF - alpha and IL-8 and can contribute to the pathogenesis of OME by increasing both the concentration of IL-8 and the secretion of mucin ; and ( ii ) IL-8 stimulates prolonged mucin secretion from goblet cells and may be involved in the maintenance of the disease in the chronic stage . - pubmed

alpha - and beta - secretase : profound changes in Alzheimer ' s disease . - pubmed

The amyloid plaque , a neuropathological hallmark of Alzheimer ' s disease , is produced by the deposition of beta - amyloid ( Abeta ) peptide , which is cleaved from Amyloid Precursor Protein ( APP ) by the enzyme beta - secretase . - pubmed

Here , we describe a decrease in alpha - secretase ( 81 % of normal ) and a large increase in beta - secretase activity ( 185 % ) in sporadic Alzheimer ' s disease temporal cortex . - pubmed

Since alpha - secretase is present principally in neurons known to be vulnerable in Alzheimer ' s disease , and there is known competition between alpha- and beta - secretase for the substrate APP , it is significant that the majority of Alzheimer samples tested here were low in alpha - secretase . - pubmed

Eighty percent of Alzheimer brains examined had an increase in beta - secretase , a decrease in alpha - secretase , or both ; which may account for the means by which the majority of people develop Alzheimer ' s disease . - pubmed

Blood glucose monitoring is recommended : to evaluate the glycemic response to the effect of insulin ; to confirm hypoglycemia ; to prevent hyperglycemia in case of disease ; in case of physical exercise . - pubmed

Flavopiridol , a cyclin - dependent kinase ( cdk ) inhibitor , can cause cell cycle arrest , induce apoptosis in cancer cells , and inhibit tumor cell growth in vivo . - pubmed

The objective of this study was to investigate the use of folate - targeted liposomes for the delivery of encapsulated oligonucleotides to folate receptor ( FR)-positive tumor cells in vitro and in vivo . - pubmed

We conclude from these results that folate liposomes can effectively deliver oligonucleotides into folate receptor - bearing cells in vitro , but additional barriers exist in vivo that prevent or decrease effective tumor uptake and retention . - pubmed

Effects of immunoregulatory cytokines ( interferon - gamma [ IFN - gamma ] and interleukin-10 [ IL-10 ] ) and HSV antigens on B7 - 1 ( CD80 ) and B7 - 2 ( CD86 ) expression on monocytes during HSV-2 infection were investigated using flow cytometry . - pubmed

Our results demonstrate that HSV-2 infection effects the expression of B7 isoforms ( B7 - 1 and B7 - 2 ) on monocytes in two ways , with opposing outcomes . - pubmed

Tuberculin - histoplasmin conversion rates in Kansas City as an indication of the prevalence of infection - preliminary report . - pubmed

We have shown that in several chronic inflammatory diseases like chronic inflammatory bowl disease , peritonitis and rheumatoid arthritis , transsignaling via the soluble IL-6R complexed to IL-6 is a crucial point in the transition from the acute to the chronic state of the disease . - pubmed

Expression of MMP-2 , MMP-7 , MMP-9 , MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas . - pubmed

The members of the matrix metalloproteinase family ( MMP ) have the ability to degrade macromolecules of the extracellular matrix and are responsible for tumor invasion and infiltration , limiting the effectiveness of the neurosurgical resection of brain tumors . - pubmed

To determine the pattern of MMP expression in astrocytic and oligodendroglial tumors , sections of astrocytic and oligodendroglial differentiated glioblastomas ( WHO grade IV ) , as well as of anaplastic oligodendrogliomas ( WHO grade III ) and anaplastic gemistocytic astrocytomas ( WHO grade III ) were immunostained for MMP-2 , MMP-7 , MMP-9 , MMP-10 and MMP-11 . - pubmed

MMP-7 , MMP-10 and MMP-11 were strongly expressed by neoplastic gemistocytic astrocytes while oligodendrocytic tumor regions showed only a low immunoreaction . - pubmed

These data indicated that MMP-7 , MMP-10 and MMP-11 contribute to the worse prognosis of astrocytic tumors when compared to oligodendrogliomas , while MMP-2 and MMP-9 might play an important role in neo - angiogenesis and tumor vascularization . - pubmed

Because cytomegaly occurs between 24 and 96 hpi , access to this larger LIP could be expected to facilitate enlargement to approximately 375 % of the initial cell size . - pubmed

The ability of Fe chelation by 100 microM SIH to limit enlargement to approximately 180 % confirms that the LIP plays a major role in cytomegaly . - pubmed

The serum HBV - DNA , HBeAg / anti - HBe , hepatic chemistry and the hepatic fibrosis markers were studied . - pubmed

CONCLUSION : These results suggested that lamivudine ( 100mg / d ) could suppress HBV - DNA replication , promote ALT normalization , accelerate HBeAg / anti - HBe seroconversion , improve the liver pathological changes , slow down the development of liver fibrosis - pubmed

Gemtuzumab ozogamicin ( GO ) , an anti - CD33 monoclonal antibody conjugated to calicheamicin , is effective as single agent in the treatment of poor risk acute myeloid leukaemia ( AML ) patients . - pubmed

The purpose of this study was to compare time- and dose - dependent cellular responses to Tpt in terms of alterations in the amount and stability of topo 1 in lung adenocarcinoma ( A-549 ) , ovarian adenocarcinoma ( CaOv-3 ) , colorectal adenocarcinoma ( HT-29 ) and breast adenocarcinoma ( MCF-7 ) cell lines . - pubmed

CONCLUSIONS : Our results suggested that disturbance of the balance of the AT1 and AT2 receptors could trigger pregnancy induced hypertension . - pubmed

Short - term intensive insulin therapy in newly diagnosed type 2 diabetes : response to Ryan , Imes , and Wallace . - pubmed

Noninvasive detection of prostate cancer by quantitative analysis of telomerase activity . - pubmed

The purpose of this study was to clarify whether quantitative analysis of telomerase activity in exfoliated cells in urine could serve as a reliable molecular marker of prostate malignancy . - pubmed

RESULTS : We report now that all prostate cancer patients revealed high levels of telomerase activity thereby showing 100 % of the assay sensitivity . - pubmed

In contrast , the majority of patients with clinically confirmed benign prostatic hyperplasia ( BPH ) did not express any telomerase activity ( 70 % of all BPH patients ) , most likely presenting cancer - free cases , or expressed low levels of activity ( 18 % ) . - pubmed

However , about 12 % of BPH patients revealed high levels of telomerase activity that potentially can reflect hidden prostate cancer . - pubmed

CONCLUSIONS : We suggest that the quantitative analysis of telomerase activity can be useful for the selection of prostate cancer and cancer - free cases . - pubmed

Indeed , there is growing evidence that the gonadotropin , luteinizing hormone , which regulates serum estrogen and testosterone concentrations , could be an important causative factor in the development of Alzheimer ' s disease . - pubmed

This review provides information supporting the " gonadotropin hypothesis , " puts forth a novel mechanism of how changes in serum luteinizing hormone concentrations could contribute to the pathogenesis of Alzheimer ' s disease , and discusses potential therapeutic anti - gonadotropin compounds . - pubmed

In situ gene expression and localization of metalloproteinases MMP1 , MMP2 , MMP3 , MMP9 , and their inhibitors TIMP1 and TIMP2 in human renal cell carcinoma . - pubmed

Alterations of MMP and TIMP expressions have been found in several malignant tumour entities . - pubmed

In this study the expression pattern of MMP1 , MMP2 , MMP3 , MMP9 , and their inhibitors TIMP1 , and TIMP2 were investigated at mRNA and protein levels in human renal cell carcinoma ( RCC ) . - pubmed

MMP1 - antigen was strongly expressed in tumour epithelium with moderate stroma expression in one case . - pubmed

The gelatinases MMP2 and MMP9 showed moderate to strong signals in tumour epithelial cells at the mRNA and protein level , while the expression in tumour stroma was moderate . - pubmed

MMP3 - mRNA and -antigen were expressed moderately to strong in tumour epithelium and focally in stroma cells . - pubmed

mRNA or TIMP1- and TIMP2 - mRNA and -antigen were also predominantly expressed in tumour epithelium ; only few samples showed positive expression in stroma cells . - pubmed

We found a pronounced expression for the gelatinases MMP2 and MMP9 and for MMP3 in RCC at the mRNA and protein level . - pubmed

The expression of TIMP1 and TIMP2 appears also to be relevant in RCC . - pubmed

Neonatal lupus is linked to the presence of anti - Ro / SS - A and anti - La / SS - B antibodies in the mother , although other factors probably of fetal origin are important . - pubmed

Haptoglobin is a positive acute - phase protein with a valuable role as a marker of inflammation in both human and veterinary medicine . - pubmed

No significant differences were produced by anticoagulants , lipaemia and bilirubinaemia , although haemolysis significantly decreased haptoglobin . - pubmed

A significant increase of haptoglobin concentration was detected in inflammatory conditions such as pyometra and leishmaniasis , in neoplastic conditions , and after glucocorticoid administration . - pubmed

In order to exclude a familiar PAH , the analysis of the bone morphogenetic protein receptor 2 gene was carried out , but no mutations were found . - pubmed

Several findings supported the hypothesis that Aer has a four - helix HAMP structure : ( i ) cross - linking independently identified the same residues at the dimer interface that were predicted by the model , ( ii ) the rate of cross - linking for residue pairs was inversely proportional to the beta - carbon distances measured on the model , and ( iii ) clockwise lesions that were not contiguous in the linear Aer sequence were clustered in one region in the folded HAMP model , defining a potential site of PAS - HAMP interaction during signaling . - pubmed

Trp63 mutations are involved in the pathogenesis of several human diseases , phenotypically characterized by ectodermal dysplasia . - pubmed

Periodic acid - Schif staining and immunohistochemical staining of CD34 were conducted to explore if VM exists in those Rb specimens . - pubmed

HIF-1alpha and VEGF expressions in Rb with VM were significantly greater than those in Rb without VM ( P = 0.001 ) . - pubmed

CONCLUSIONS : VM exists in Rb . - pubmed

Highly differentiated Rb exhibits more VM than that in less differentiated Rb . - pubmed

Expression of HIF-1alpha and VEGF is greater in Rb with VM , indicating that these factors may stimulate the occurrence of VM . - pubmed

CONCLUSIONS : Our study confirmed a close association between preoperative glucose control indicated by HbA ( 1c ) levels & lt;7 % and a decreased risk of postoperative infectious complications . - pubmed

IFN - gamma - receptor signaling ameliorates transplant vasculopathy through attenuation of CD8 + T - cell - mediated injury of vascular endothelial cells . - pubmed

However , MCMV - LacZ infection of recipients of ifngr(-/- ) Tie2 - LacZ hearts led to massive activation of beta - gal - specific CD8 T cells , and led to development of fulminant TV . - pubmed

Further analyses revealed that the strong systemic IFN - gamma " storm " associated with MCMV infection induced upregulation of programmed death-1 ligand 1 ( PD - L1 ) on EC , and subsequent attenuation of programmed death-1 ( PD-1)-expressing EC - specific CD8(+ ) T cells . - pubmed

Thus , IFNGR signaling in ECs activates a potent peripheral negative feedback circuit that protects vascularized grafts from occlusive TV . - pubmed

These patients were predominantly male ( 92.9 % vs 80.3 % , P & lt ; 0.001 ) , more likely to smoke ( 75.8 % vs 47.2 % , P & lt ; 0.001 ) , obese ( 48.2 % vs 27.9 % , P = 0.002 ) , have higher triglyceride levels ( 176.9 + /- 153.8 mg / dL vs 140.7 + /- 112.7 mg / dL , P = 0.005 ) , and lower high - density lipoprotein cholesterol ( 37.1 + /- 7.9 mg / dL vs 42.8 + /- 14.3 mg / dL , P = 0.005 ) than older patients . - pubmed

The recombinant outer membrane protein OprF / I has been demonstrated in previous studies to protect against Pseudomonas aeruginosa infection through a mechanism of enhanced antibody - mediated opsonophagocytosis . - pubmed

aeruginosa binding to IFN - gamma , suggesting an alternative mechanism by which the OprF / I vaccine confers protection against P. - pubmed

Multiple regression analysis revealed that the factors contributing to the elevation of ABR threshold were congenital diaphragmatic hernia , severe respiratory disease , and a high C - reactive protein ( CRP ) level . - pubmed

Factors significantly related to an elevation of ABR threshold were a history of congenital diaphragmatic hernia , severe respiratory disease , and elevation of CRP . - pubmed

We present a case of metastatic CDC that responded favorably to a multiple tyrosine kinase inhibitor , sunitinib , achieving a partial response in both lung and skeletal metastases . - pubmed

Considering these findings , it would be worthwhile prospectively investigating the role of multiple tyrosine kinase inhibitors , particularly sunitinib , in the management of metastatic CDC . - pubmed

[ The expression of CEACAM-1 and CXCL-14 in infantile hemangioma ] . - pubmed

OBJECTIVE : To examine the expression of CEACAM - land CXCL-14 in the different stages of infantile hemangioma and to explore the role of CEACAM-1 and CXCL-14 in the occurrence and development of infantile hemangioma . - pubmed

METHODS : The expression of CEACAM-1 and CXCL-14 was detected by immunohistochemical technique and Western Blot in cases of proliferating hemangiomas , involuting hemangiomas , involuted hemangiomas . - pubmed

RESULTS : The expression of CEACAM-1 in early stage of proliferating hemangiomas was weak or negative , while it was strong in involuting hemangiomas and positive in the involuted stage . - pubmed

The expression of CXCL-14 was weak or negative in stage of proliferating hemangiomas , positive in involuting hemangiomas and strong in the involuted stage . - pubmed

CONCLUSIONS : CEACAM-1 and CXCL-14 are involved in the occurrence and development of infantile hemangioma . - pubmed

We planned this case - control study to evaluate the relationship between hypogonadism , as defined by the sexual hormone profile ( FSH , LH , testosterone ( T ) and prolactin ) and ED , as assessed by means of an internationally validated self - administered questionnaire ( IIEF ) . - pubmed

DM1 patients had significantly increased mean levels of both gonadotropins ( FSH and LH ) ( p < 0.0001 ) and a reduced mean level of T ( p < 0.0001 ) when compared to controls . - pubmed

Twelve patients were eugonadic ( normal LH , T , and FSH ) , while 18 displayed hormonal evidence of hypogonadism , characterized by tubular failure ( increased FSH ) in all the subjects and associated with interstitial failure in 14 subjects : seven with primary hypogonadism ( increased LH and reduced T ) and seven with compensated hypogonadism ( increased LH and normal T ) . - pubmed

In general , patients with recent onset RA have earlier clinical improvement when treated with initial combination therapy with prednisone or a tumor necrosis factor inhibitor than when treated with initial monotherapy . - pubmed

Rac1 is necessary for their transition from G1 to S phase , at least in part by regulating cyclin D levels and retinoblastoma protein phosphorylation . - pubmed

Purine / Pyrimidine nucleotides ratio ( OD 260 : OD 280 ) was also measured RESULTS : P5'N-1 deficient patients showed reduction in P5'N-1 activity ( Mean + - SD ; 4.06 + - 0.66 using an ELISA reader & amp ; 6.25 + - 1.37 using a spectrophotometer ) as compared to the normal control group ( ELISA reader : 13.24 + - 3.42 & amp ; Spectrophotometer : 18.25 + - 3.20 ) . - pubmed

[ Generation of antitumor response against hepatocellular carcinoma by in vitro transduction of dendritic cells with adeno - associated virus expressing alpha - fetoprotein ] . - pubmed

OBJECTIVE : To investigate the generation of antitumor response against hepatocellular carcinoma by in vitro transduction of dendritic cells ( DC ) with recombinant adeno - associated virus expressing alpha - fetoprotein ( rAAV - AFP ) . - pubmed

19.84 % of CD4(+)T cells and 18.65 % of CD8(+)T cells activated by AAV - AFP + DC produced IFN - gamma but not IL-4 and showed distinct killing activities against AFP positive hepatocellular carcinoma cell lines HepG2 ( 56.45 % ) and BEL7402 ( 78.84 % ) . - pubmed

CONCLUSION : AAV - AFP + DC can elicit distinct antitumor responses against AFP positive hepatocellular carcinoma cell lines so as to provide a basis for further researches on the clinical application of AAV - AFP + DC in the treatment of hepatocellular carcinoma . - pubmed

Anaemia during pregnancy : impact on birth outcome and infant haemoglobin level during the first 18 months of life . - pubmed

To determine the effect of maternal anaemia on pregnancy outcome and describe its impact on infant haemoglobin level in the first 18 months of life , we conducted a prospective study of 617 pregnant women and their children in Benin . - pubmed

There was no association between an infant 's haemoglobin level until 18 months and maternal anaemia . - pubmed

However , malaria attacks during follow - up , male gender and sickle cell trait were all associated with a lower infant haemoglobin level until 18 months , whereas good infant feeding practices and a polygamous family were positively associated with a higher haemoglobin level during the first 18 months of life . - pubmed

Analysis of serum total IgE , specific IgE and eosinophils in children with acute and chronic urticaria . - pubmed

BACKGROUND / PURPOSE : Increased IgE and eosinophil levels are frequently observed in cutaneous inflammation and are thought to provoke the occurrence of urticaria . - pubmed

The aim of this study was to compare serum total IgE levels , specific IgE sensitization rates and eosinophil percentages between acute and chronic urticaria in children . - pubmed

Serum levels of total IgE , prevalence of sensitization to food and aeroallergens and blood eosinophil percentages were compared by the disease duration of urticaria . - pubmed

RESULTS : There were no statistical differences in total IgE production , positive sensitization to specific allergens and eosinophil percentages between the patients with acute and chronic urticaria . - pubmed

CONCLUSION : Boys potentially have a higher serum IgE expression than girls children with urticaria . - pubmed

IgE levels and eosinophil percentages are not good indicators for a prolonged course of urticaria . - pubmed

Plasma fatty acid - binding protein 4 , nonesterified fatty acids , and incident diabetes in older adults . - pubmed

OBJECTIVE : To examine the relation of fatty acid - binding protein ( FABP ) 4 and nonesterified fatty acids ( NEFAs ) to diabetes in older adults . - pubmed

For each SD increase in log FABP4 , hazard ratios ( HRs ) for diabetes were 1.35 ( 95 % CI 1.10 - 1.65 ) for women and 1.45 ( 1.13 - 1.85 ) for men controlling for age , race , education , physical activity , cystatin C , alcohol intake , smoking , self - reported health status , and estrogen use for women ( P for sex - FABP4 interaction 0.10 ) . - pubmed

BMI modified the FABP4 - diabetes relation ( P = 0.009 overall ; 0.02 for women and 0.135 for men ) , in that statistically significant higher risk of diabetes was mainly seen in men with BMI & lt;25 kg / m(2 ) ( HR per SD : 1.78 [ 95 % CI 1.13 - 2.81 ] ) . - pubmed

CONCLUSIONS : Plasma FABP4 was positively associated with incident diabetes in older adults , and such association was statistically significant in lean men only . - pubmed

All 19 neoplasms were positive for thyroid transcription factor 1 and thyroglobulin but negative for parathyroid hormone and calcitonin . - pubmed

Following the consumption of contaminated food or water by a human host , the Vibrio cholerae bacterium produces virulence factors , including cholera toxin ( CT ) , which directly causes voluminous diarrhea , producing cholera . - pubmed

CD8 + T - cell activation in HIV-1 - infected patients experiencing transient low - level viremia during antiretroviral therapy . - pubmed

We found that TLLV does not significantly change CD8 T - cell activation and that higher CD8 T - cell activation during viral suppression & lt;50 copies per milliliter is associated with a modest increase in the risk of a subsequent TLLV . - pubmed

Intra - acinar cell activation of digestion enzymes triggers the events of acute pancreatitis and stimulates the production of inflammatory cytokines . - pubmed

Finally , inflammatory cytokines trigger inflammatory cascades that lead to systemic inflammatory response syndrome , multi - organ failure , or death . - pubmed

However , a possible correlation between RBC MTX and MTXGlu2 - 5 concentrations and clinical outcomes of MTX treatment in RA is debated . - pubmed

Main changes of blood biochemical included hypokalemia , lactic acidosis , hyperglycemia , hypsocreatinkinase . - pubmed

Median overall survival for mucin positive and mucin negative tumors was 4(1.3 - 5.7 ) and 3.3(0.1 - 6.3 ) years respectively . - pubmed

Expected 5 year disease free and overall survival for mucin positive and mucin negative tumors was 73 % and 89 % ( P = 0.1 ) and 75 % and 87 % ( P = 0.4 ) . - pubmed

CONCLUSION : Acellular mucin pools in rectal cancer following a PCR to neoadjuvant treatment do not impact survival . - pubmed

RESULTS : Compared with men ( n = 765 ) , women ( n = 274 ) were older ( p & lt ; 0.001 ) and more likely to have hypertension ( p & lt ; 0.001 ) , diabetes ( p = 0.002 ) , and higher low - density lipoprotein cholesterol ( LDL - C ) ( p = 0.01 ) , high - density lipoprotein cholesterol ( p & lt ; 0.001 ) , and C - reactive protein ( CRP ) ( p = 0.004 ) levels . - pubmed

Greater PAV regression in women versus men occurred with rosuvastatin ( p = 0.004 ) , those with diabetes ( p = 0.01 ) , stable coronary disease ( p = 0.01 ) , higher baseline LDL - C ( p = 0.02 ) , and higher CRP ( p = 0.04 ) levels . - pubmed

Annexin A5 promotes invasion and chemoresistance to temozolomide in glioblastoma multiforme cells . - pubmed

Annexin A5 reportedly promotes progression and chemoresistance in a variety of cancers . - pubmed

In the present study , we explored the effects of annexin A5 on GBM cell invasion and chemoresistance to temozolomide . - pubmed

Stable overexpression and knockdown of annexin A5 were performed in both U-87 MG and U-118 MG human GBM cell lines . - pubmed

In conclusion , our study provides the first evidence that annexin A5 promotes GBM cell invasion , MMP-2 expression / activity , and chemoresistance to temozolomide through a PI3K - dependent mechanism . - pubmed

It adds new insights not only into the biological function of annexin A5 but also into the molecular mechanisms underlying GBM progression and chemoresistance . - pubmed

AIM : The treatment strategy for steroid - resistant nephrotic syndrome remains uncertain at present , especially in those with calcineurin inhibitor resistance or intolerance . - pubmed

To date , few studies have been published using multiple combination therapy of immunosuppressive reagents for children with calcineurin inhibitor - resistant or -intolerant nephrotic syndrome . - pubmed

Biochemical parameters included the following : ( a ) indices of CLGI ( high - sensitivity C - reactive protein , erythrocyte sedimentation rate and fibrinogen ) ; ( b ) insulin resistance ( Homeostasis Model Assessment of Insulin Resistance index ) ; ( c ) adiposity ( plasma adiponectin ) . - pubmed

Additionally , 3.8 % of the rifampin - resistant isolates showing no mutation in the rpoB gene were significantly associated with mixed infections ( chi(2 ) , 56.78 ; P & lt ; 0.01 ) . - pubmed

This study revealed for the first time that Manu2 was the predominant group in the cases of mixed infections , and this might be the main reason for heteroresistance and a possible mechanism for isolates without any mutation in the rpoB gene to become rifampin resistant . - pubmed

Relationship of endothelial area with VEGF - A , COX-2 , maspin , c - KIT , and DOG-1 immunoreactivity in liposarcomas versus non - lipomatous soft tissue tumors . - pubmed

Although DOG-1 is considered a specific marker for gastrointestinal tumors ( GISTs ) , its positivity , correlated with c - KIT and VEGF immunoexpression , was also shown by dermatofibrosarcomas and tumors with histiocytic and lipomatous differentiation , suggesting its possible pro - angiogenic role . - pubmed

Maspin expression was observed in adipose tissue tumors only . - pubmed

Regarding angiogenesis , 31 of the 55 cases were VEGF - positive , such positivity being directly correlated with COX-2 and CD34 positivity as evaluated in the tumor cells and also with MVD . - pubmed

Based on these aspects , we conclude that VEGF / COX-2 - induced angiogenesis is specific for non - lipomatous tumors , whereas liposarcomas are dependent on the VEGF / maspin angiogenic pathway . - pubmed

The DOG-1 / c - KIT / VEGF target may be used for further personalized therapy of soft tissue sarcomas . - pubmed

No data about DOG-1 and maspin positivity in liposarcomas have been published to date . - pubmed

The presence of a strong connection between reported COX-2 inhibitors and cardiac toxicity encourages medicinal chemists to explore new scaffolds . - pubmed

Starting from our lead compound 5a , structure - based drug - design was conducted and more potent analogues were obtained with high COX-2 selectivity and almost full edema protection , in carrageenan - induced edema assay , in case of compound 5e . - pubmed

No other demographic or clinical factors , such as cardiac disease , diabetes mellitus , smoking , lipid status , serum fibrinogen , hematocrit , antiphospholipid antibody titer , or ultrasound results of the carotid arteries entered the model . - pubmed

PURPOSE : The fully human monoclonal antibody nivolumab binds to the programmed death-1 ( PD-1 ) receptor , blocking interactions between PD-1 and its ligands on tumor cells and preventing T cell exhaustion in patients with cancer . - pubmed

In recent years , gefitinib , an epidermal growth factor receptor tyrosine kinase inhibitor , has shown its good antitumor activities in treating NSCLC in a number of studies . - pubmed

In this study , we identified a novel lncRNA , GClnc1 , which was upregulated and associated with tumorigenesis , tumor size , metastasis , and poor prognosis in gastric cancer . - pubmed

GClnc1 affected gastric cancer cell proliferation , invasiveness , and metastasis in multiple gastric cancer models . - pubmed

Mechanistically , GClnc1 bound WDR5 ( a key component of histone methyltransferase complex ) and KAT2A histone acetyltransferase , acted as a modular scaffold of WDR5 and KAT2A complexes , coordinated their localization , specified the histone modification pattern on the target genes , including SOD2 , and consequently altered gastric cancer cell biology . - pubmed

Thus , GClnc1 is mechanistically , functionally , and clinically oncogenic in gastric cancer . - pubmed

Targeting GClnc1 and its pathway may be meaningful for treating patients with gastric cancer . - pubmed

This study reveals that GClnc1 is an oncogenic lncRNA in human gastric cancer . - pubmed

High throughput chemical library screening identifies a novel p110 - delta inhibitor that potentiates the anti - myeloma effect of bortezomib . - pubmed

The phosphatidyl - inositol-3 - kinase ( PI3 K ) pathway is constitutively hyperactivated in MM to promote disease progression and drug resistance . - pubmed

While inhibiting PI3 K induces apoptosis in MM and is predicted to increase tumor susceptibility to anticancer therapy , early - generation pan - PI3 K inhibitors display poor clinical efficacy as well as intolerable side effects . - pubmed

Here , we found that PI3 K activity is significantly upregulated in MM cell lines and patient tumor cells resistant to bortezomib and that the majority of PI3 K activity in MM cells is dependent upon the p110 - delta isoform . - pubmed

Genetic or pharmacologic inhibition of p110 - delta substantially reduced myeloma viability and enhanced cellular sensitivity to bortezomib . - pubmed

Taken together , the results provide the basis for further clinical evaluation of p110 - delta inhibitors , as monotherapy or in synergistic combinations , for the benefit of MM patients . - pubmed

The Arabidopsis thaliana T - DNA insertion mutant glucose hypersensitive ( ghs ) 40 - 1 exhibited hypersensitivity to glucose ( Glc ) and abscisic acid ( ABA ) . - pubmed

Lung injury was accompanied by the upregulation of PLTP and IL-8 in the CSE - exposed rat model , and the number of white blood cells in the BALF was significantly increased compared with those of the controls . - pubmed

Topoisomerase 1 ( TOP1 ) poisons like camptothecin ( CPT ) are currently used in cancer chemotherapy but these compounds can have damaging , off - target effects on neurons leading to cognitive , sensory and motor deficits . - pubmed

Genomic pathways modulated by Twist in breast cancer . - pubmed

There is evidence to indicate that Twist expression plays a role in breast tumor formation and metastasis , but the role of Twist in dysregulating pathways that drive the metastatic cascade is unclear . - pubmed

Moreover , many of the genes and pathways dysregulated by Twist in cell lines and mouse models have not been validated against data obtained from larger , independant datasets of breast cancer patients . - pubmed

METHODS : We over - expressed the human Twist gene in non - metastatic MCF-7 breast cancer cells to generate the estrogen - independent metastatic breast cancer cell line MCF-7 / Twist . - pubmed

Microarray data was collected from both in vitro ( MCF-7 and MCF-7 / Twist cell lines ) and in vivo ( primary tumors and lung metastases ) models of Twist expression . - pubmed

RESULTS : Our data establishes a Twist over - expressing mouse model of breast cancer , which metastasizes to the lung and replicates some of the ontogeny of human breast cancer progression . - pubmed

CONCLUSIONS : Analogous gene expression patterns were observed in both in vitro and in vivo Twist preclinical models of breast cancer metastasis and breast cancer patient datasets supporting the functional role of Twist in promoting breast cancer metastasis . - pubmed

The data suggests that genetic dysregulation of Twist at the cellular level drives alterations in gene pathways in the Twist metastatic mouse model which are comparable to changes seen in human breast cancers . - pubmed

In ~50 % of prostate cancers , chromosomal rearrangements cause the fusion of the promoter and 5'-UTR of the androgen - regulated TMPRSS2 ( transmembrane protease , serine 2 ) gene to the open reading frame of ERG , encoding an ETS family transcription factor . - pubmed

ERG is not expressed in normal prostate epithelia , but when expressed , it promotes tumorigenesis via altered gene expression , stimulating epithelial - mesenchymal transition , cellular migration / invasion , and transformation . - pubmed

In conclusion , our findings have identified critical molecular mechanisms involving ERK - mediated ERG activation that could be exploited for therapeutic intervention in ERG - positive prostate cancers . - pubmed

Glycobiology of syndecan-1 in bacterial infections . - pubmed

Loss of Sdc1 in mice is a gain - of - function mutation that significantly decreases the susceptibility to several bacterial infections , suggesting that subversion of Sdc1 is an important virulence strategy . - pubmed

Here , we discuss several examples of Sdc1 subversion in bacterial infections . - pubmed

Synergistic antiproliferative effects of an mTOR inhibitor ( rad001 ) plus gemcitabine on cholangiocarcinoma by decreasing choline kinase activity . - pubmed

This study aims to investigate a novel therapeutic regimen [ gemcitabine plus everolimus ( rad001 ) , an mTOR inhibitor ] for cholangiocarcinoma . - pubmed

In the in vitro study , gemcitabine plus rad001 exerted a synergistic therapeutic effect on the cholangiocarcinoma cells , irrespective of the KRAS mutation status . - pubmed

In the xenograft study , gemcitabine plus rad001 showed the best therapeutic effect on tumor volume change , and was associated with increased caspase-3 expression , decreased eIF4E expression , as well as overexpression of both death receptor- and mitochondrial apoptotic pathway - related genes . - pubmed

We concluded that gemcitabine plus rad001 has a synergistic antiproliferative effect on cholangiocarcinoma , irrespective of the KRAS mutation status . - pubmed

PURPOSE OF REVIEW : Defining predisposition to allergic drug reactions has largely focussed on HLA associations , but other genetic and nongenetic factors are also likely to be involved . - pubmed

RECENT FINDINGS : Polymorphic genetic variants in cytokine genes , including IL-10 , and co - signalling pathways , including CTLA4 , have been associated with allergic drug reactions , but the effect size is lower than with HLA alleles and most associations have not been replicated . - pubmed

Although TCR specificity seems to be important for CBZ - induced SJS / TEN in South East Asian patients , a distinct repertoire may not play a role in reactions to other drugs . - pubmed

Histamine dysregulation has been identified as a rare genetic cause of tic disorders ; mice with a knockout of the histidine decarboxylase ( Hdc ) gene represent a promising model of this pathophysiology . - pubmed

The H3R histamine receptor is elevated in the striatum of Hdc KO mice , and H3R agonists , acting in the dorsal striatum , trigger tic - like movements in the model . - pubmed

Mutations in the collagen genes COL4A1 and COL4A2 cause Mendelian eye , kidney and cerebrovascular disease including intracerebral haemorrhage ( ICH ) , and common collagen IV variants are a risk factor for sporadic ICH . - pubmed

COL4A1 and COL4A2 mutations cause endoplasmic reticulum ( ER ) stress and basement membrane ( BM ) defects , and recent data suggest an association of ER stress with ICH due to a COL4A2 mutation . - pubmed

We performed a preventative oral treatment of Col4a1 mutant mice with the chemical chaperone phenyl butyric acid ( PBA ) , which reduced adult ICH . - pubmed

However , PBA treatment did not alter eye and kidney defects , establishing tissue - specific outcomes of targeting Col4a1 - derived ER stress , and therefore this treatment may not be applicable for patients with eye and renal disease . - pubmed

Alleviating ER stress is a valid therapeutic target for preventing and treating established adult ICH , but collagen IV patients will require stratification based on their clinical presentation and mechanism of their mutations . - pubmed

Furthermore , to evaluate the molecular mechanism involved in cancer cell death , we studied the genes that are involved in fatty acid and cholesterol biosynthesis pathway including 3 - hydroxy-3 - methylglutaryl - coenzyme A reductase ( HMGCR ) , Acetyl CoA synthase ( ACC ) , sterol regulatory element - binding protein ( SPREPB1 ) and fatty acid synthase ( FASN ) respectively . - pubmed

HMGB1 gene polymorphism is associated with coronary artery lesions and intravenous immunoglobulin resistance in Kawasaki disease . - pubmed

Recent reports of elevated serum high mobility group box 1 ( HMGB1 ) level during the acute phase of KD and its relationship to poor response to IVIG treatment suggest a possible association of HMGB1 polymorphisms with KD . - pubmed

We investigated the association between the polymorphisms of the HMGB1 gene , KD susceptibility , coronary artery lesions , and KD response to IVIG treatment . - pubmed

RESULTS : The HMGB1 single nucleotide polymorphisms were not associated with KD susceptibility . - pubmed

CONCLUSION : The rs1412125 in HMGB1 might be a risk factor for the development of coronary artery lesions and IVIG resistance in KD patients . - pubmed

Additionally , we provided evidence that DNMTs control the global hypomethylation of oncogenes , including ALOX5AP and CSF3R that otherwise have high methylation in normal colons . - pubmed

Such genes were also more sensitive to DNMT changes , such as in CRC . - pubmed

Two comparative assessments of intravenous immunoglobulin therapy switching patterns in the treatment of chronic inflammatory demyelinating polyneuropathy in the US . - pubmed

Tapentadol is a novel analgesic molecule that synergistically combines two mechanisms of action , micro - opioid receptor agonism and norepinephrine reuptake inhibition , and for which multiple literature data are available that confirm its efficacy and safety in controlling pain . - pubmed

Computational screening of phytochemicals against survivin protein : A potent target for cancer . - pubmed

RESULTS : EOCs were heterogeneous , frequently harboring KRAS , PIK3CA , PTEN , CTNNB1 , ARID1A and TP53 mutations . - pubmed

EOCs were distinct from HGSOCs at the mutational level , less frequently harboring TP53 but more frequently displaying KRAS , PIK3CA , PIK3R1 , PTEN and CTNNB1 mutations . - pubmed

Compared to synchronous EOCs and pure EECs , pure EOCs less frequently harbored PTEN , PIK3R1 and ARID1A mutations . - pubmed

Akin to EECs , EOCs could be stratified into the four molecular subtypes : 3 % POLE ( ultramutated ) , 19 % MSI ( hypermutated ) , 17 % copy - number high ( serous - like ) and 61 % copy - number low ( endometrioid ) . - pubmed

In addition to microsatellite instability , a subset of EOCs harbored potentially targetable mutations , including AKT1 and ERBB2 hotspot mutations . - pubmed

AIMS : To examine whether the presence of two common missense variants in the CYP2C9 gene ( rs1799853 , encoding Arg144Cys and denoted as * 2 , and rs1057910 , encoding Ile359Leu and denoted as * 3 ) influences the acute physiological response to a single glipizide dose in individuals naive to diabetes medications . - pubmed

CONCLUSIONS : Carriers of two reduced function alleles in CYP2C9 may experience an increased insulin response to glipizide and be predisposed to a higher risk of hypoglycaemia , although no effect of genotype was seen in glucose - based measurements . - pubmed

Material and methods : In the Maria Sklodowska - Curie Institute - Oncology Centre , between 2011 and 2017 , 318 non - resectable or metastatic melanoma patients were treated with immune checkpoint inhibitors : anti - CTLA-4 or / and anti - PD-1 . - pubmed

Among this group 10 % of patients had brain metastases , 24 % of patients had BRAF mutant melanoma , and co - morbidities were present in 86 % of patients ( mainly hypertension , cardiovascular diseases and/or diabetes ) . - pubmed

This integrative analysis revealed that tumors with high stromal clustering and barrier had reduced expression of pathways involved in naive CD4 signalling , MAPK and PI3 K signalling . - pubmed

Endothelin-1 ( ET-1 ) , an endogenous vasoactive peptide , has been found to play an important role in peripheral pain signaling . - pubmed

Acid - sensing ion channels ( ASICs ) are key sensors for extracellular protons and contribute to pain caused by tissue acidosis . - pubmed

Finally , we showed that pharmacological blockade of ASICs by amiloride or APETx2 significantly alleviated ET-1 - induced flinching and mechanical hyperalgesia in rats . - pubmed

Tooth extractions in patients under antiresorptive therapy for osteoporosis : Primary closure of the extraction socket with a mucoperiosteal flap versus application of platelet - rich fibrin for the prevention of antiresorptive agent - related osteonecrosis of the jaw . - pubmed

PURPOSE : The aim of this study was to compare primary closure of the extraction socket to application of platelet - rich fibrin ( PRF ) without subsequent primary closure for the prevention of osteonecrosis of the jaw ( ONJ ) in patients administered antiresorptive therapy for osteoporosis . - pubmed

RECOMMENDATIONS : In the adjuvant setting , nivolumab or pembrolizumab should be offered to patients with resected stage IIIA / B / C / D BRAF wild - type cutaneous melanoma , while either of those two agents or the combination of dabrafenib and trametinib should be offered in BRAF - mutant disease . - pubmed

In the unresectable / metastatic setting , ipilimumab plus nivolumab , nivolumab alone , or pembrolizumab alone should be offered to patients with BRAF wild - type cutaneous melanoma , while those three regimens or combination BRAF / MEK inhibitor therapy with dabrafenib / trametinib , encorafenib / binimetinib , or vemurafenib / cobimetinib should be offered in BRAF - mutant disease . - pubmed

lncRNA - PRLB Confers Paclitaxel Resistance of Ovarian Cancer Cells by Regulating RSF1 / NF - kappaB Signaling Pathway . - pubmed

Background : The long noncoding RNA ( lncRNA)-PRLB ( progression - associated lncRNA in breast cancer ) has been identified to enhance the drug resistance of breast cancer cells . - pubmed

In this study , the authors explored PRLB effect in the paclitaxel ( Tax ) resistance of ovarian cancer cells and revealed the role of RSF1 ( remodeling and spacing factor 1)/nuclear factor kappaB ( NF - kappaB ) signaling in this process . - pubmed

The expressions of PRLB in Tax resistant tissues and cells of ovarian cancer were detected using the real time polymerase chain reaction assay . - pubmed

Results : PRLB expression was obviously enhanced in the Tax resistant ovarian cancer tissues and cells . - pubmed

Conclusion : This study reveals that knockdown of PRLB improves the sensitivity of ovarian cancer cells to Tax , at least in part , through inhibiting the activation of RSF1 / NF - kappaB signaling through targeting miR-150 - 5p . - pubmed

While IMCL content scales negatively with insulin resistance , athletes are highly insulin sensitive in contrast to T2D patients , the so - called athlete 's paradox . - pubmed

Thus , we developed a novel fluorescent super - resolution microscopy approach and found that PLIN2 protein abundance at the LD surface was higher in T2D patients than in athletes . - pubmed

While PLIN5 abundance at the LD surface was similar in athletes and T2D patients , we have observed previously that the number of PLIN5 decorated LDs was higher in athletes , indicating more LDs in close association with mitochondria . - pubmed

Anti - cN1A antibodies do not correlate with specific clinical , EMG or pathological findings in sporadic inclusion body myositis . - pubmed

INTRODUCTION : Anti - cytosolic 5 '- nucleotidase 1A ( cN1A ) antibodies are commonly detected in patients with sIBM . - pubmed

RESULTS : Anti - cN1A antibodies were present in 47/92 ( 51 % ) patients with sIBM . - pubmed

The antibody titer did not correlate with the clinical phenotype , CK value or presence of myotonic discharges on EMG . - pubmed

Anti - cN1A antibody positive patients appeared to have more frequent auto - aggressive inflammation on muscle biopsy but not as an isolated myopathological feature . - pubmed

DISCUSSION : Our study showed that anti - cN1A antibody positive and negative sIBM patients have similar clinical features and disease severity . - pubmed

Anti - cN1A antibodies in our sIBM cohort did not correlate with any studied clinical or laboratory parameter and , therefore , were of limited value in the patient 's assessment . - pubmed

5 - Hydroxy-4 - methoxycanthin-6 - one alleviates dextran sodium sulfate - induced colitis in rats via regulation of metabolic profiling and suppression of NF - kappaB / p65 signaling pathway . - pubmed

A UPLC - Q - TOF - MS / MS approach - based metabolomics analysis was conducted to explore the underlying mechanisms of PQ - A in colitis treatment . - pubmed

CONCLUSIONS : We provide an overview of PQ - A 's possible mechanism of action in colitis treatment based on serum non - targeted metabolomics . - pubmed

PQ - A treatment can protect rats against DSS - induced colitis by suppressing the NF - kappaB / p65 signaling pathway . - pubmed

Patients with critical disease had significantly lower levels of anti - HCoV OC43 - NP ( p = 0.016 ) and HCoV HKU1 - NP ( p = 0.023 ) antibodies at the first encounter compared to other COVID-19 patients . - pubmed

Endothelin-1 caused a significant decrease in UF , UNaV and UKV only at a later period , despite a relatively early depression of renal haemodynamics . - pubmed

In this study we compared 2 putative biochemical markers for rejection of pancreas allografts , serum immunoreactive anodal trypsinogen and urinary amylase , with serum creatinine in 15 simultaneously transplanted type I diabetics . - pubmed

ISDN and its two main hepatic metabolites , isosorbide-2 - mononitrate ( IS-2 - MN ) and isosorbide-5 - mononitrate ( IS-5 - MN ) were compared for their ability to inhibit platelet aggregation and thromboxane B2 generation in vitro in response to threshold concentrations of ADP , adrenaline , collagen , thrombin and arachidonic acid . - pubmed

Characterization of mammalian type IX collagen fragments from limited pepsin digests of a transplantable swarm rat chondrosarcoma . - pubmed

Collagenous fragments from type IX molecules have been solubilized by limited pepsin proteolysis of a transplantable rat chondrosarcoma and isolated by selective salt precipitation . - pubmed

streptokinase ( SK ) in the treatment of acute myocardial infarction ( AMI ) in two cardiac care units . - pubmed

The time interval from the beginning of acute symptoms to the arrival at the hospital was 2.8 + /- 1.2 hours ( 1 to 15 ) and from that moment to administration of SK was 1.6 + /- 1.4 h. The whole interval to the administration of SK was 4.4 + /- 2.5 h. RESULTS : The 3 criteria of reperfusion ( pain relief , ST changes resolution and less than 18 h maximum CK rise ) were present in 36 % of the pts , 2 of the criteria in 21 % , and 41 % of the pts had only one or no criteria . - pubmed

Role of insulin and counter - regulatory hormones in the control of hepatic glycerolipid synthesis and low - density - lipoprotein catabolism in diabetes . - pubmed

[ High - dose immunoglobulins in immune thrombocytopenic purpura ] . - pubmed

Twenty - four patients with immune thrombocytopenic purpura ( ITP ) were treated with high doses of intravenous immunoglobulin ( Ig ) . - pubmed

Alpha 1 - fetoprotein and carbonic anhydrase B and C concentration in cord blood from newborn infants of diabetic mothers . - pubmed

[ Prolactin adenoma in a irl whose mother had had a pituitary adenoma with amenorrhea - galactorrhea ] . - pubmed

Serial renal biopsies for glomerular culture , histochemical staining for beta - glucuronidase , electron microscopy ( EM ) and light microscopy , were used to study macrophage involvement in experimental chronic immune complex ( IC ) glomerulonephritis ( GN ) induced in rabbits by daily intravenous injections of bovine serum albumin ( BSA ) . - pubmed

We conclude that opiate receptor stimulation by morphine causes inhibition of the vagally mediated component of water - induced bronchoconstriction . - pubmed

The effect of oral Kallikrein treatment on sperm motility in asthenozoospermia . - pubmed

Nineteen men with asthenozoospermia were treated with oral Kallikrein ( 600 U daily for 12 weeks ) and sperm motility evaluated in 16 of these patients . - pubmed

[ Phase-1 study of the tolerance for increasing doses of recombinant human alpha 2 interferon in patients with advanced cancer ] . - pubmed

Thirteen patients with malignant tumors were entered into a phase I trial with recombinant DNA human alpha 2 interferon ( IFN alpha 2 ) . - pubmed

Defective Fc receptor - mediated function of the mononuclear phagocyte system in lupus nephritis . - pubmed

To determine whether patients with systemic lupus erythematosus and nephritis have more profound defects in mononuclear phagocyte system clearance than their counterparts without renal disease , we studed Fc receptor - mediated splenic clearance function in 32 patients . - pubmed

Neither B8 nor DR3 histocompatibility antigen markers differentiated the renal and nonrenal disease subgroups . - pubmed

The greater Fc receptor - mediated clearance dysfunction , which occurs in patients with lupus erythematosus and nephritis , could lead to enhanced glomerular deposition of immune complexes as a primary event , or as a secondary event amplifying previously established lesions . - pubmed

A group of patients with stage T1B2 disease and pathologically negative lymph nodes showed excellent 10 - year survival rates and freedom from clinical evidence of disease , while prostate specific antigen ( PSA ) correlations in 10 - year survivors indicate that 88 % were clinically free of cancer and had a PSA level of less than 4.0 mg./nl . - pubmed

In serial samples from nine posttransfusion hepatitis C patients , NS5 and E2 antibodies did not appear earlier than classical HCV antibodies . - pubmed

Re : " Alcohol , smoking , coffee , and cirrhosis " and " coffee and serum gamma - glutamyltransferase : a study of self - defense officials in Japan " . - pubmed

[ Antigenemia and CD4 + cell count in HIV-1 infected patients ] . - pubmed

In a peptide competition cytotoxicity ( PCC ) assay , based on inhibition of CTL lysis by competition for binding to MHC class - I molecules between a known CTL epitope - containing peptide and peptide of interest , E7 49 - 57 bound 45 - fold more efficiently to Db than the second Db - binding peptide in line . - pubmed

The abnormal proliferation of cardiac fibroblasts and deposition of the ECM protein , collagen , associated with hypertension and myocardial infarction , may adversely affect the performance of the heart . - pubmed

Angiotensin II , aldosterone and endothelins play a central role in the remodeling of the ECM in hypertension , and decrease collagenase activity and/or increase collagen synthesis in cultured cells . - pubmed

Angiotensin II is a principal determinant in vivo of cardiac fibroplasia and synthesis of the ECM proteins , collagen and fibronectin . - pubmed

Cardiac fibroblasts respond to angiotensin II with hyperplastic / hypertrophic growth , and increased expression of collagen , fibronectin , and integrins . - pubmed

Association of protease activity against IGFBP-3 with peritoneal fluid mitogens : possible implications for the ectopic growth of endometrial cells in women with endometriosis . - pubmed

BACKGROUND : Recent data indicate the implication of an IGF / IGFBP / protease system in the development of ectopic implants of endometrium ( endometriosis ) in the pelvic cavity . - pubmed

MATERIAL AND METHODS : We characterized mitogens and protease(s ) against IGFBP-3 in the peritoneal fluid of women with or without endometriosis using preparative isoelectric focusing ( IEC ) Proteineous fractions were tested for a ) mitogenic activity on NIH / 3T3 cells and KLE endometrial - like cells , b ) proteinolytic activity against radiolabeled IGFBP-3 , and c ) protein analysis using SDS - PAGE . - pubmed

CONCLUSION : The preparative isoelectric focusing system would be an advantageous approach to investigate the possible implication of the PF proteases with IGFBP-3 limited proteolysis generating PF mitogen(s ) which possibly participate in the pathophysiology of endometriosis . - pubmed

Fas - mediated cytotoxicity was quantified by counting the number of cells present in discrete patches of OSE 0 and 8 h after Fas mAb treatment . - pubmed

Further studies should establish whether the beta3AR is coupled to other signaling pathways in human brown adipocytes and whether these may contribute to BAT hypertrophy and/or thermogenesis . - pubmed

Molecular analysis of the cholera toxin gene & amp ; antibiotic sensitivity profile of Vibrio cholerae O1 & amp ; O139 associated with mixed infection . - pubmed

To determine whether glucocorticoid resistance due to mutations in the glucocorticoid receptor ( GRL ) gene is associated with premature pubarche , hirsutism , or oligo / amenorrhea , we performed single - strand conformational polymorphism analysis of genomic DNA obtained from 25 children and 16 adolescent girls referred for the evaluation of premature pubarche , hirsutism , or oligo / amenorrhea . - pubmed

We conclude that glucocorticoid resistance due to GRL mutations is an infrequent cause of mild hyperandrogenism . - pubmed

Hb saale OR alpha 2beta 2 84(EF8)Thr --> ; Ala. A new abnormal hemoglobin was detected in a young German anemic patient by cation - exchange high performance liquid chromatography ( HPLC ) . - pubmed

Minor manifestations include fever , arthralgia and laboratory findings of elevated erythrocyte sedimentation rate , C - reactive protein and prolonged PR interval on ECG . - pubmed

[ Telomerase activity in liver cancer and the adjacent tissue ] . - pubmed

OBJECTIVE : To investigate the possibility of using telomerase as a tumor marker for human primary hepatocellular carcinomas ( HCC ) . - pubmed

METHODS : Human liver specimens , comprising 33 HCC and adjacent peritumoral tissues , 4 hepatic metastases and the adjacent peritumoral tissues , 6 benign liver lesions and 6 normal liver tissues , were examined for telomerase activity by TRAP assay based on PCR . - pubmed

Telomerase activity was negative in 6 nomal liver tissues and 5 of 6 benign liver lesions . - pubmed

There was no correlation between the clinical stage of HCC and their telomerase activity . - pubmed

CONCLUSION : Positive telomerase activity occurs in the majority of HCC examined . - pubmed

Subsequent studies suggested that protein kinase C - dependent and tyrosine kinase - dependent pathways are important in LB induction during hypoxia . - pubmed

Immune system in adults with childhood - onset growth hormone deficiency : effect of growth hormone therapy . - pubmed

OBJECTIVE : To investigate the impact of growth hormone ( GH ) therapy in adults with childhood - onset GH deficiency on immune system . - pubmed

METHODS : Ten young GH deficient adults ( 7 males , age 19 - 28 years ) were treated with recombinant human growth hormone for 6 months . - pubmed

These observations suggest a temporary immune complex formation after the onset of GH treatment which might play a partial role in developing oedema as a side effect of GH treatment , besides the known effect of GH on water retention . - pubmed

CONCLUSIONS : GH therapy in GH deficient young adults has a measurable effect on the increase of CD4 / CD8 ratio and on the formation of immune complexes . - pubmed

Aptamer significantly reduced the thrombin - induced platelet degranulation ( 46+/-20 % inhibition at 0.15 U / ml thrombin , P<.001 ) , as well as thrombin - mediated platelet aggregation in PRP ( 7+/-10 % inhibition at 1 U / ml thrombin , P<.05 ) . - pubmed

BRCA1 carries tumor suppressor activity distinct from that of p53 and p21 . - pubmed

The loss of BRCA1 function appears as an essential step in breast and ovarian epithelial cells oncogenesis and is consistent with the concept that BRCA1 acts as a tumor suppressor gene . - pubmed

In 1996 , a retroviral vector was used for BRCA1 delivery to demonstrate that the transfer of BRCA1 inhibits breast and ovarian cancer cell growth . - pubmed

Since this early observation , the tumor growth inhibitory activity of BRCA1 in vivo has not been further documented . - pubmed

Delivery of wild - type BRCA1 by an adenovirus vector in breast and ovarian tumor cells , decreases in vitro proliferation and tumorigenicity . - pubmed

Similarly , in vivo administration of BRCA1 provokes tumor growth retardation or regression comparable to that obtained with p53 or p21 . - pubmed

[ ACE - dependent and sympathetic components of blood pressure regulation in patients with essential hypertension ] . - pubmed

UNLABELLED : The development of arterial hypertension is accompanied by impairment of the normal ratio of the " ACE - depending " and of the sympathetic nervous system , correlates with the action on the main pharmacological " targets " : I - I - imidazoline receptors ( moxonidine ) or the ACE activity ( enalapril ) . - pubmed

The aim of the present investigation was to determine the hypotensive and metabolic effects of moxonidine and enalapril depending on the basal ACE activity in patients with arterial hypertension , complicated with the metabolic syndrome . - pubmed

Effectiveness of moxonidine and enalapril administration ( during 24 weeks ) depended on the basal ACE activity in the hypertensive patients : ( a ) in the group of patients with low basal ACE activity moxonidine very effectively decreased systolic and diastolic blood pressure , compared with the group of patients with high basal ACE activity ; ( b ) influence of enalapril on the level of arterial blood pressure was more pronounced with high basal ACE activity . - pubmed

IN CONCLUSION : choosing a hypotensive treatment for patients with the metabolic syndrome , it is advisable to take into account the basal ACE activity levels . - pubmed

Spinal PGE ( 2 ) application facilitated dorsal horn neuronal firing elicited by ionophoretic delivery of NMDA , suggesting that an interaction of PGs and NMDA receptors may contribute to inflammation - induced central sensitization . - pubmed

Maple syrup urine disease ( MSUD ) is an inborn error of metabolism stemming from a deficiency in 2 - ketoacid dehydrogenase and resulting in the systemic accumulation of branched chain amino acids ( BCAAs ) . - pubmed

Misexpression of dHAND in the anterior compartment of the limb bud induces ectopic expression of sonic hedgehog , with resulting preaxial polydactyly and mirror image duplications of posterior digits . - pubmed

The solute carrier gene family SLC26 consists of tissue - specific anion exchanger genes , three of them associated with distinct human recessive disorders . - pubmed

Interleukin-6 release in the hepatic blood outflow during normothermic liver ischaemia in humans . - pubmed

In liver ischaemia - reperfusion injury , cytokines play a key proinflammatory role . - pubmed

AIMS : The aim of our study was to analyse the cytokine pattern in the hepatic blood outflow in patients undergoing surgical intervention of partial liver resection with clamping of the hepatic pedicle and liver ischaemia , and to correlate the cytokine behaviour with clinical parameters . - pubmed

RESULTS : We found a significant increase of the IL-6 levels in the supra - hepatic samples during liver ischaemia , while the trend with IL-1alpha was less clear ; IFN - gamma and TNF - alpha were undetectable with the methods used . - pubmed

IL-6 levels appeared to correlate positively with bilirubin and gamma - GT levels and negatively with the degree of acidosis . - pubmed

Cytokines could contribute to modulate the inflammatory response to liver ischaemia . - pubmed

Blockade of airway inflammation and hyperresponsiveness by HIV - TAT - dominant negative Ras . - pubmed

In this study , we evaluated the role of Ras in Ag - induced airway inflammation and hyperresponsiveness by i.p . - pubmed

OVA challenge also caused airway hyperresponsiveness to methacholine , which was dose dependently blocked by treatment with TAT - dnRas . - pubmed

By contrast , TAT - green fluorescent protein or dnRas lacking the TAT protein transduction domain did not block airway inflammation , cytokine production , or airway hyperresponsiveness . - pubmed

We conclude that Ras mediates Th2 cytokine production , airway inflammation , and airway hyperresponsiveness in immune - sensitized mice . - pubmed

Previous molecular biological analysis documented that MUTZ-11 cells carry both an FLT3 internal tandem duplication ( ITD ) and an MLL partial tandem duplication ( PTD ) . - pubmed

molecular biological alterations ( FLT3 ITD + MLL PTD ) . - pubmed

Ligands of peroxisome proliferator - activated receptor gamma ( PPARgamma ) have been shown to inhibit growth in different tumor cell lines . - pubmed

Activation of PPARgamma by its synthetic ligands might have a therapeutic role in advanced NB . - pubmed

A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin . - pubmed

RESULTS : MMP-2 , MMP-9 , uPA , PAI-1 , IGF-2 , BFGF , VEGF , ANG-1 , IRS-1 , and TSP-1 were significantly ( p & lt ; or = 0.05 ) upregulated in CIS and INV , whereas TIMP-1 , ANG-2 , MASPIN , IGF1 - R and HBEGF were unchanged . - pubmed

IGF-1 was uniquely elevated in IDP . - pubmed

SPARC was downregulated in CIS . - pubmed