Sentences with gene / disease entities
Legend:
GENE/PROTEIN
CHEMICAL
DISEASE
SPECIES
CELLINE
Human erythrocyte carbonic anhydrase B and C in
chronic obstructive lung disease . -
pubmed
The levels of
carbonic anhydrase B and C isozymes in
human red cells were determined using a quantitative immunological technique in
patients with
chronic obstructive lung disease . -
pubmed
The produced quantity of
lecithinase does not affect the toxicity of strains upon
oral infection of the animals experimented . -
pubmed
Abnormal bleeding is the key to early diagnosis , and the frequent use of sensitive
HCG assays is the key to proper followup . -
pubmed
Spontaneous elimination of
HCG from the circulation following moler pregnancy , as indicated by sensitive assay , would predict a benign postmolar course ; no patient in the current series who once achieved undetectable levels of
HCG developed
malignant trophoblastic disease . -
pubmed
The ability of the
human interleukin-1 receptor antagonist ,
IL-1ra , to inhibit aerosolized antigen - induced
airway hyperreactivity to i.v . -
pubmed
In conclusion ,
IL-1ra inhibited antigen - induced
airway hyperreactivity to i.v . -
pubmed
substance P and bronchoalveolar lavage fluid inflammatory leukocyte influx in the
guinea pig , in a time - dependent manner , suggesting that
cytokines , such as
IL-1 , may contribute to the pathophysiology surrounding this
pulmonary anaphylaxis model . -
pubmed
Interferon therapy for chronic
NANB hepatitis . -
pubmed
Characterization of
keratinocyte plasminogen activator inhibitors and demonstration of the prevention of pemphigus
IgG - induced
acantholysis by a purified
plasminogen activator inhibitor . -
pubmed
Following only 15 min of
ischemia , apical membrane enrichment of
NaK - ATPase , normally a basolateral membrane ( BLM ) enzyme , had increased ( 1.6 + /- 0.6 vs. 2.9 + /- 1.2 , P less than 0.01 ) . -
pubmed
Following
ischemic injury ( 50 min ) ,
LAP staining could be seen within the cell and along the BLM . -
pubmed
With cellular recovery from
ischemic injury ( 5 days ) ,
LAP was again only visualized in the apical membrane . -
pubmed
[
Plasma cholecystokinin level in
chronic pancreatitis ] . -
pubmed
Thus , in
chronic pancreatitis ( cP ) , which leads to a decrease of digestive enzyme secretion , increases in plasma
CCK may be postulated . -
pubmed
H1 receptor antagonist treatment of
chronic rhinitis . -
pubmed
In
patients with
chronic rhinitis ,
H1 receptor antagonists play an important role in relieving the symptoms of
sneezing ,
itching , and
rhinorrhea . -
pubmed
The proteolysis caused by purified
calpain II was similar to proteolysis occurring during the formation of several experimental
cataracts in
rodents ; this suggested that the enzyme may play a role in
cataract formation . -
pubmed
Elevated
serum follicle - stimulating hormone (
FSH ) levels and
azoospermia were seen in all male
patients after completion of induction and consolidation therapy as a result of germ cell and stem cell loss . -
pubmed
Significance of elevated urinary
N - acetyl - beta - D - glucosaminidase activity in chronic
cadmium poisoning . -
pubmed
N - Acetyl - beta - D - glucosaminidase (
NAG ) activity and
beta 2 - microglobulin (
beta 2 - m ) concentration were measured in the urine of
inhabitants of a
cadmium - polluted area (
Cd ) , including
patients with , or suspected , "
itai - itai " disease and control subjects . -
pubmed
Urinary
NAG activity thus represents another useful indicator of
renal tubular damage caused by
Cd poisoning since the mechanisms for the excretion of
NAG and beta 2 - m into urine are thought to be different . -
pubmed
Expression of
abl and other oncogenes is independent of metastatic potential in
Abelson virus - transformed malignant
murine large cell lymphoma . -
pubmed
Analysis of the susceptibility of the transforming activities of lymphocyte - neoplasm DNAs to digestion with
restriction endonucleases indicated that the same or closely related transforming genes were activated in independent
neoplasms representative of the same stage of
normal cell differentiation . -
pubmed
The unfractionated extract and the fraction bound by Concanavalin A - Sepharose had similar ability to detect specific
IgG in sera from
patients with
aspergillosis . -
pubmed
An enzyme - linked immunosorbent assay for
urinary albumin in
patients with
insulin - dependent diabetes mellitus . -
pubmed
In this report , we developed an enzyme - linked immunosorbent assay ( ELISA ) for the measurement of urinary
albumin (
UA ) and examined UA in 38
patients with
insulin - dependent diabetes mellitus (
IDDM ) . -
pubmed
the urinary protein of the cases with
microalbuminuria consisted mainly of
albumin , and in the case of
nephropathy , an
IgG band was also detected . -
pubmed
Acute renal failure with
ACE inhibition in
aortic coarctation . -
pubmed
The neurochemistry of
vomiting involves
serotonin and
serotonin S3 receptors . -
pubmed
Muscle fiber atrophy in leg muscles after
botulinum toxin type A treatment of
cervical dystonia . -
pubmed
To further study possible distant effects of repeated
BTX - A injections , we obtained percutaneous muscle biopsies of the vastus lateralis muscle from 11
patients with
cervical dystonia . -
pubmed
We postulate that the observed
atrophy is due to distant effects of
botulinum toxin causing progressive denervation - like changes in non - treated muscle . -
pubmed
Adenoviral E1A - associated protein p300 is involved in
acute myeloid leukemia with t(11;22)(q23;q13 ) . -
pubmed
We identify here that the
p300 gene is fused to the MLL gene and that in - frame
MLL -
p300 fusion protein is generated in
acute myeloid leukemia (
AML ) with t(11 ; 22)(q23 ; q13 ) . -
pubmed
These findings suggest that the basis for the leukemogenesis of t(11 ; 22)-
AML is the inability of
p300 to regulate cell - cycle and cell differentiation after fusion with
MLL . -
pubmed
Prospective study of
calcium channel blocker use ,
cardiovascular disease , and total mortality among
hypertensive women : the Nurses ' Health Study . -
pubmed
BACKGROUND : In several observational studies , patients prescribed
calcium channel blockers had higher risks of
cardiovascular diseases and mortality than those prescribed other antihypertensive medications . -
pubmed
Women prescribed
calcium channel blockers had a higher prevalence of
ischemic heart disease . -
pubmed
An association between
calcium channel blocker use and
myocardial infarction was apparent among women who had ever smoked cigarettes ( covariate - adjusted RR , 1.81 ; 95 % CI , 1.20 to 2.72 ) but not among never - smokers ( RR , 0.94 ; 95 % CI , 0.48 to 1.84 ) . -
pubmed
CONCLUSIONS : In analyses adjusted only for age , we found a significant elevation in RR of total
myocardial infarction among women who used
calcium channel blockers compared with those who did not . -
pubmed
The
p52 / p65 heterodimer formed in the nucleus , bound specifically to the promoter of the
tumor suppressor protein
p53 , effecting a 25 to 30 - fold increase in the level of this protein . -
pubmed
Analysis of gene - environment interaction in
coronary artery disease :
lipoprotein lipase and smoking as examples . -
pubmed
Results from a prospective study on
CAD risk in healthy middle - aged men show that the risk associated with the
LPL - D9N variant , which has a modest effect on plasma
triglyceride levels , is enhanced up to 10 fold , but only in men who smoke . -
pubmed
The proposed mechanism for this
LPL : smoking interaction on
CAD risk is the subject of this review . -
pubmed
Telomerase activity and
hTERT mRNA in development and progression of
adenoma to
colorectal cancer . -
pubmed
Telomerase activity and
hTERT mRNA expression are upregulated in
colorectal cancer . -
pubmed
We examined
telomerase activity by the fluorescence - based telomeric repeat amplification protocol method and analyzed the level of
hTERT mRNA by real - time polymerase chain reaction in 74 surgically obtained
neoplasms from 29
patients . -
pubmed
These results suggest that
telomerase activation occurs during the progression from low - grade to
high - grade dysplasia in
adenomas and increases steadily with the progression of the degree of
dysplasia and invasion during colorectal
carcinogenesis , and that
hTERT mRNA expression is a feature of the late stage development of
colorectal cancer . -
pubmed
Through a genome - wide cDNA microarray , we identified that the paternally expressed gene 10 (
PEG10 ) was highly expressed in a great majority of
hepatocellular carcinomas , although its expression was absent in normal liver cells . -
pubmed
Exogenous expression of
PEG10 conferred oncogenic activity and transfection of
hepatoma cells with antisense
S - oligonucleotides suppressing
PEG10 resulted in their growth inhibition . -
pubmed
These findings suggested that development of drug(s ) inhibiting
PEG10 activity could be a novel approach for the treatment of
hepatocellular carcinomas . -
pubmed
Stress - induced release of
HSC70 from
human tumors . -
pubmed
These findings indicate that
HSC70 can be actively released from
tumor cells and is indicative of a previously unknown mechanism by which immune modulators stimulate the release of intracellular
HSC70 . -
pubmed
This mechanism may account for the potent chaperokine activity of
heat shock proteins recently observed during
heat shock protein - based immunotherapy against a variety of
cancers . -
pubmed
Corticotropin and
cortisone ; dosage and ratio of intramuscular and intravenous
corticotropin (
ACTH ) and oral
cortisone in treatment of certain
dermatoses . -
pubmed
Haemoglobin E in Burmese ; two cases of
haemoglobin E disease . -
pubmed
2 CASES OF THE
NEONATAL FORM OF GENERALIZED CONGENITAL CYTOMEGALIC DISEASE ] . -
pubmed
LPAM (
alpha 4 beta 7 integrin ) is an important
homing integrin on alloreactive T cells in the development of
intestinal graft - versus - host disease . -
pubmed
We conclude that the
alpha ( 4 ) beta ( 7 ) integrin is important for the invasion of alloreactive donor T cells into the gut and the subsequent development of intestinal
GVHD and overall
GVHD morbidity and mortality . -
pubmed
UNLABELLED : Levels of some markers of coagulation and platelet activation such as
prothrombin fragment 1 + 2 ( F1 + 2 )
thrombin -
antithrombin complex (
TAT ) and
von Willebrand factor (
vWF ) , are related to outcome in non ST - segment elevation
acute coronary syndrome (
NSTEACS ) . -
pubmed
AIM : To study changes of markers of coagulation and platelet activation during short term use of
ticlopidine and
clopidogrel in
NSTEACS patients treated with
aspirin and
antithrombin . -
pubmed
CONCLUSION : Short term use of
ticlopidine in
patients with
NSTEACS treated with
aspirin and unfractionated
heparin was associated with lower levels of
TAT and
fibrinogen ( relative to control group ) on day 14 . -
pubmed
Both
ticlopidine and
clopidogrel used in regimes with loading doses in
NSTEACS patients treated with
aspirin and
antithrombin prevented acute phase elevation of
vWF . -
pubmed
Kinase Suppressor of Ras1 (
KSR1 ) functions as a positive modulator of
Ras - dependent signaling either upstream of or parallel to
Raf-1 , and pharmacologic inactivation of
KSR1 may serve as a treatment for
Rasdriven malignancies such as
pancreatic cancer ( Xing , H. R. , Cordon - Cardo , C. , Deng , X. , Tong , W. , Campodonico , L. , Fuks , Z. , and Kolesnick , R. ( 2003 ) Nat . -
pubmed
Preeclampsia and the C282Y mutation in the
hemochromatosis (
HFE ) gene . -
pubmed
PURPOSE : Muscle
insulin resistance is characterized by the inability of a normal
insulin concentration to produce a favorable rate of
glucose uptake . -
pubmed
METHODS : A review of the relative research from my laboratory and the scientific literature was performed to obtain information on the muscle
insulin resistance of the
obese Zucker
rat and its response to exercise training . -
pubmed
RESULTS : The
insulin resistance of the
obese Zucker
rat results from defects in the
insulin signaling cascade , which limits translocation of the
glucose transporter
GLUT4 to the plasma membrane upon
insulin binding to its receptor . -
pubmed
Exercise training improves the muscle
insulin resistance of
obese Zucker
rat but does not correct the defects in
insulin signaling or
GLUT4 translocation . -
pubmed
All
patients had cerebrospinal fluid
pleocytosis and
WNV - specific
IgM in the cerebrospinal fluid and/or serum . -
pubmed
Urinary
zinc excretion and serum
insulin were significantly higher in the same group , although the
insulinemia and the parameters of
zinc nutritional status were not significantly correlated . -
pubmed
PpGalec , a tandem repeat galectin expressed in the midgut of the sandfly
Phlebotomus papatasi , is used by Leishmania major as a receptor for mediating specific binding to the insect midgut , an event crucial for parasite survival , and accounts for species - specific vector competence for the most widely distributed form of
cutaneous leishmaniasis in the Old World . -
pubmed
Tissue transglutaminase and
celiac disease . -
pubmed
Effects of
histone deacetylase inhibitor
FR901228 on the expression level of
telomerase reverse transcriptase in
oral cancer . -
pubmed
We speculated whether or not the expression level of
telomerase reverse transcriptase (
hTERT ) would be modulated by agents targeting epigenetics in
oral cancer cell lines . -
pubmed
In the present study , the epigenetic effects of the
histone deacetylase (
HDAC ) inhibitor
FR901228 on
hTERT transcription in
oral cancer cell lines were analyzed by RT - PCR . -
pubmed
We performed indirect genetic association studies of
SRD5A1 and
SRD5A2 and the
dihydrotestosterone /
testosterone ratio that reflects the activity of
5alpha - reductase in 57 males with
type 2 diabetes . -
pubmed
Virus - specific
CD8 + T cell responses play an important role in the natural course of
infection ; however , the impact of certain
CD8 + T cell responses in determining clinical outcome has not been fully defined . -
pubmed
However , the finding is especially significant because
HLA - B27 has also been shown to have a protective role in
HIV infection . -
pubmed
In conclusion , our results suggest a dominant role of
HLA - B27 in mediating spontaneous viral clearance as well as viral evolution in
HCV infection and mechanistically link both associations to a dominant novel
CD8 + T cell epitope . -
pubmed
Manganese superoxide dismutase (
Mn - SOD ) gene polymorphisms in
urolithiasis . -
pubmed
Polymorphism in
manganese superoxide dismutase gene (
Mn - SOD ) is a new approach to identify its probable association with
urolithiasis . -
pubmed
A
valine (
Val ) to
alanine (
Ala ) substitution at amino acid 16 , occurring in the mitochondrial targeting sequence of the
MnSOD gene , has been associated with an increase in
urolithiasis risk . -
pubmed
This study was conducted to investigate the association of
MnSOD gene polymorphism with the risk of
urolithiasis . -
pubmed
MnSOD genotype determination may provide a tool to identify
individuals who are at risk of
urolithiasis . -
pubmed
The assessment of
diabetes compensation is based on
glycated haemoglobin , and
glycated albumin is also recommended in certain cases . -
pubmed
Deciding on the therapy ( oral antidiabetic drugs vs.
insulin therapy or a combination of both ) is based on
diabetic care standards ; cooperation between the diabetologist and the dialysis doctor is desirable . -
pubmed
The purpose of this study was to determine whether oral EM could improve the periprosthetic tissue profiles and reduce serum
cytokine production in
AL patients who are candidates for surgical revision . -
pubmed
Our results demonstrate that oral EM reduces the
inflammation of periprosthetic tissues , as manifested by the reduction of the numbers of infiltrating cells ,
CD68 + macrophages ,
RANKL+ cells , and
TRAP+ cells . -
pubmed
Dual oral antiplatelet therapy with
aspirin and oral
ADP - receptor antagonists , such as
clopidogrel , has been the standard choice for prevention of
ischemic events in
patients with
acute coronary syndrome and in those undergoing percutaneous coronary intervention . -
pubmed
Cangrelor is a reversible , potent , competitive inhibitor of the
ADP P2Y ( 12 ) receptor that is administered intravenously and rapidly achieves near complete inhibition of
ADP - induced
platelet aggregation . -
pubmed
Despite an abundance of data describing expression of genes in the
Candida albicans ALS (
agglutinin - like sequence ) gene family , little is known about the production of
Als proteins on individual cells , their spatial localization or stability . -
pubmed
Development of an
ErbB - overexpressing
A-431 optical reporting
tumor xenograft model to assess targeted photodynamic therapy regimens . -
pubmed
To better assess the efficacy of
erbB - targeted therapies , it would help to have optical reporting
human tumor xenograft models that abundantly express
erbB receptors . -
pubmed
A GFP /
luciferase clone ,
A-431 / D4 , and an RFP / luciferase clone ,
A-431 / G4 , were obtained that exhibit
erbB1 expression levels and
tumor growth kinetics similar to the parental cells . -
pubmed
To demonstrate the utility of the optical reporting clones ,
A-431 / G4 tumors were grown subcutaneously in
nude mice and treated with vascular - targeted photodynamic therapy ( PDT ) , which targets the angiogenic consequences of
erbB signaling . -
pubmed
A-431 / D4 and
A-431 / G4 optical reporting
tumor models should also prove useful for assessing therapies that directly target the
erbB1 receptor . -
pubmed
Genetic revelations charge
APOL1 variants with
kidney disease susceptibility . -
pubmed
Our data suggest that these
tumors share a common genomic program that includes inactivation of a master regulator of the
p53 and
Rb pathways ,
CDKN2A / B , and activation of
FGFR4 ,
Ras , and
Hedgehog (
Hh ) signaling . -
pubmed
The
CDKN2A / B
tumor suppressor is deleted in most patient samples . -
pubmed
FGFR4 , which encodes a
receptor tyrosine kinase , is activated in 20 % of
tumors , predominantly by amplification of mutant , activating
FGFR4 alleles . -
pubmed
We also identified intragenic deletions affecting
NF1 , a
tumor suppressor and inhibitor of
Ras , in 15 % of
tumor samples . -
pubmed
Deletion of
NF1 and the presence of activating
Ras mutations ( in 42 % of patients ) were mutually exclusive , suggesting
NF1 loss is an alternative and potentially common mechanism of
Ras activation in
ERMS . -
pubmed
The aim of the present study was to describe the effects of beta - blocker
metoprolol monotherapy and combined with
calcium channel inhibitor
felodipin on digital microcirculation in primary
Raynaud ' s syndrome . -
pubmed
RESULTS AND CONCLUSIONS : Our investigation concludes that the concurrent administration of beta - blockers with
calcium channel inhibitors positively reduces symptoms in
patients suffering from
Raynaud ' s syndrome . -
pubmed
Upregulation of
recepteur d'origine nantais tyrosine kinase and cell invasiveness via
early growth response-1 in
gastric cancer cells . -
pubmed
Abnormal accumulation and activation of the
recepteur d'origine nantais (
RON ) has been implicated in carcinogenesis of
epithelial tumors . -
pubmed
RON expression was induced by the
tumor promoter ,
phorbol 12 - myristate 13 - acetate (
PMA ) , in
gastric adenocarcinoma AGS cells . -
pubmed
These results suggest that tumor promoter induces
RON expression via
Egr-1 , which , in turn , stimulates cell invasiveness in
AGS cells . -
pubmed
We previously reported that
mice lacking
surfactant protein A (
SP - A ) have increased airway hyperresponsiveness ( AHR ) during M
pneumoniae infection versus wild - type
mice mediated by
TNF - alpha . -
pubmed
Mast cells ( MCs ) have been implicated in AHR in
asthma models and produce and respond to
TNF - alpha . -
pubmed
OBJECTIVE : Determine the contribution of MC /
TNF interactions to AHR in airways lacking functional
SP - A during
Mp infection . -
pubmed
METHODS : Bronchoalveolar lavage fluid was collected from healthy and
asthmatic subjects to examine
TNF - alpha levels and M pneumoniae positivity . -
pubmed
RESULTS : Our findings indicate that high
TNF - alpha levels correlate with M pneumoniae positivity in
human asthmatic patients and that
human SP - A inhibits M pneumoniae - stimulated transcription and release of
TNF - alpha by MCs , implicating a protective role for
SP - A. -
pubmed
Using
SP - A(-/-)Kit(W - sh / W - sh )
mice engrafted with
TNF - alpha(-/- ) or
TNF receptor (
TNF - R)(-/- ) MCs , we found that
TNF - alpha activation of MCs through the
TNF - R , but not
MC - derived TNF - alpha , leads to augmented
AHR during M
pneumoniae infection when
SP - A is absent . -
pubmed
CONCLUSION : Our data highlight a previously unappreciated but vital role for MCs as secondary responders to
TNF - alpha during the host response to
pathogen infection . -
pubmed
Effect of transcatheter renal arterial embolization combined with cryoablation on regulatory
CD4+
CD25 + T lymphocytes in the peripheral blood of
patients with advanced
renal carcinoma . -
pubmed
OBJECTIVE : To analyze the effect of
Argon - Helium cryosurgery ( AHCS ) combined with transcatheter renal arterial embolization ( TRAE ) on the differentiation of regulatory
CD4 +
CD25 + T cell ( Treg ) and its implication in
patients with
renal carcinoma . -
pubmed
COX1 is largely constitutively expressed , whereas
COX2 is induced at sites of
inflammation and
vascular injury . -
pubmed
These observations have raised interest in the use of
COX inhibitors and
PGI ( 2 ) analogs in the management of pregnancy - associated and neonatal
vascular disorders . -
pubmed
Alabama birds also displayed lower inflammatory
cytokine signaling and lower
fever early in
infection . -
pubmed
Oxidized low - density lipoprotein (
ox - LDL ) is directly associated with chronic
vascular inflammation . -
pubmed
To understand whether
thioredoxin1 (
Trx1 ) participates in an antiinflammatory defense mechanism in
atherosclerosis , we investigated the effect of
Trx1 on the expression of two
adhesion molecules ,
vascular cell adhesion molecule-1 (
VCAM-1 ) and
intercellular adhesion molecule-1 (
ICAM-1 ) , in
human umbilical vein endothelial cells (
HUVECs ) . -
pubmed
These results suggest that
Trx1 inherently suppresses
VCAM-1 and
ICAM-1 expression in vascular endothelia and may prevent the initiation of
atherosclerosis by attenuating
adhesion molecule expression . -
pubmed
FokI polymorphism in the
vitamin D receptor gene (
VDR ) and its association with
lumbar spine pathologies in the Italian population : a case - control study . -
pubmed
The association between
VDR polymorphisms and
spine disorders has been analyzed in different ethnic groups , focusing on the functional
FokI polymorphism . -
pubmed
The aims of this study were to evaluate , in the Italian white population , the
VDR FokI polymorphism frequencies distribution in subjects with clearly defined
lumbar spinal pathologies compared to asymptomatic controls and to analyze the interplay of genetic and conventional risk factors . -
pubmed
In conclusion , the link we observed between
VDR FokI variants and specific
lumbar spine pathologies suggests that
spinal tissue degeneration is influenced by the genetic background . -
pubmed
Future studies should evaluate the signaling pathways involving alterations in
VDR and influencing the development and/or progression of
spine disorders . -
pubmed
We find that gene expression patterns within early
neoplasias are distinct from both
normal and
breast cancer patterns and identify a pattern of pro - oncogenic changes , including elevated transcription of
ERBB2 ,
FOXA1 , and
GATA3 at this early stage . -
pubmed
Measurements of protein expression by immunohistochemistry on an independent set of early
neoplasias confirms that
ER pathway regulators
FOXA1 and
GATA3 , as well as
ER itself , are consistently upregulated at this early stage . -
pubmed
Therefore , the differential - binding profile for the six lineages could have implications in the immunopathology of
Chagas ' disease , affecting the complex network of immune responses on which
galectins mediate , thus providing linkage clues to the notion that different lineages may be related to different clinical forms of the disease . -
pubmed
This study reported a case of an 11 - month - old male infant with
mitochondrial disease characteristics and
subclinical hypothyroidism ( a high
thyrotropin level ) . -
pubmed
This case adds to the growing literature of
mitochondrial disorders caused by
mitochondrial ATPase 6 mutations . -
pubmed
Lymphocytotoxicity inhibition : a reliable method for
HL - A typing of
cultured cell lines . -
pubmed
Despite normal or high total
P-450 , in vivo drug metabolism was impaired in
subjects with altered parenchyma , suggesting that other factors were limiting
antipyrine elimination in
liver disease . -
pubmed
In a case of
osteogenesis imperfecta with multiple
fractures already from childhood ,
myelomatosis was diagnosed at the age of 52 years because of a serum M - component (
IgG , lambda ) , Bence Jones
proteinuria ,
myeloma cells in the bone marrow , and
osteolytic skeletal lesions . -
pubmed
Scleroderma (
progressive systemic sclerosis ;
PSS ) is a
connective tissue disorder in which excessive
collagen is deposited in the skin and internal organs . -
pubmed
Results indicate that ( 1 ) the proliferative influence of serum of
patients with
PSS is not different from that of normal donors , ( 2 ) increased proliferation and
procollagen gene expression are not linked in affected or unaffected dermal fibroblasts , and ( 3 ) affected
PSS fibroblasts produce a stimulatory factor(s ) for
procollagen gene expression to which they are differentially sensitive . -
pubmed
Expression of the neuronal form of
pp60c - src in
neuroblastoma in relation to clinical stage and prognosis . -
pubmed
The expression of the protooncogene
c - src has been studied in specimens of childhood
tumors with special reference to
neuroblastoma and other
tumors of neuronal origin . -
pubmed
For comparison
c - src gene expression was studied in seven
neuroblastoma and
neuroepithelioma cell lines . -
pubmed
While
pp60c - src was found in most
tumors studied , the neuronal form was restricted to
neuroblastomas ( 23 of 27 ) and
retinoblastomas ( 3 of 3 ) and could not be detected in the other childhood
tumors . -
pubmed
A dominance of the neuronal form ,
pp60c - srcN , was exclusively found in the infant cases of
neuroblastoma ( 9 of 12 ) , estimated to have good prognosis . -
pubmed
These results indicate that
pp60c - srcN might be a diagnostic marker in primitive
childhood tumors . -
pubmed
When expressed in higher amounts than
pp60c - src ,
pp60c - srcN may be a positive prognostic marker in
neuroblastoma , especially useful in the evaluation of infants . -
pubmed
In addition , lack of
pp60c - srcN seems to be incompatible with low stage
neuroblastoma . -
pubmed
To determine if increases in the target cell free intracellular
Ca2 + concentration ( [
Ca2+]i ) are also important for
cytotoxicity , we examined the effects of
Ca2 + substitutes , promotors of
Ca2 + influx ; and inhibitors of
Ca2 + efflux on the cytolysis mediated by purified
cytolysin . -
pubmed
Ethacrynic acid , a potent inhibitor of
glutathione S - transferases (
GST ) , has been shown to enhance the
cytotoxicity of
chlorambucil in
drug resistant cell lines , but a definite mechanism has not been established . -
pubmed
[ Experience with using automated
insulin infusion systems in
diabetes mellitus type 1 ] . -
pubmed
Neurotoxicity of
parathyroid hormone in
uremia . -
pubmed
The steady - state level of truncated myc RNAs in
J558 was comparable to that in another
plasma cell tumor line (
MPC-11 ) which harbors a translocated
c - myc locus without an IAP element . -
pubmed
Adenylate cyclase activity in kidney of partially nephrectomized
uremic rats : decreased sensitivity to
arginine - vasopressin in kidney medulla . -
pubmed
Immunoglobulin E and A levels in atopic and
anaphylactic children . -
pubmed
IgE levels were high in both atopic and
anaphylactic patients but higher in the atopic than in the
anaphylactic group . -
pubmed
A multiple - dose phase I trial of
recombinant leukocyte A interferon in
cancer patients . -
pubmed
Eighty - one
patients with a variety of refractory disseminated
malignant neoplasms have been treated in the first multiple fixed - dose phase I trial of
recombinant leukocyte A interferon (
IFL - rA ) . -
pubmed
The toxic reactions seen with IFL - rA resembled those of
nonrecombinant leukocyte interferon and included
fever ,
chills ,
fatigue ,
anorexia ,
myalgia ,
headache , occasional
nausea and
vomiting , and dose - dependent reversible
leukopenia and hepatic transaminase elevations . -
pubmed
Serum
haptoglobin as
tumor marker . -
pubmed
Interferon response in
chronic myeloid leukaemia correlates with
ABL /
BCR expression : a preliminary study . -
pubmed
alpha - Interferon (
IFN ) has been used to induce cytogenetic remission in
chronic myeloid leukaemia (
CML ) , but there are few indicators to predict
IFN response . -
pubmed
The function and clinical significance of the newly discovered
ABL /
BCR mRNA has not been investigated for a correlation with
CML prognosis or response to therapy . -
pubmed
We have used a two - step
reverse transcriptase polymerase chain reaction ( RT - PCR ) to detect the transcripts of the chimaeric genes
BCR /
ABL ,
ABL /
BCR , as well as the normal
ABL and
BCR genes in 24
CML patients treated with
IFN . -
pubmed
However , 7/10
ABL /
BCR mRNA positive patients achieved a major cytogenetic response to
IFN ; but of the 13
ABL / BCR mRNA negative patients , only two achieved a major cytogenetic response ( P = 0.013 ) . -
pubmed
A single parameter , oxygenated
hemoglobin , can be used to quantify experimental irritant - induced
inflammation . -
pubmed
Rapid detection of
transferrin receptor expression on
glioma cell lines by using magnetic microspheres . -
pubmed
A rapid method for detecting the presence of
transferrin receptors (
TR ) on
human glioblastoma - derived cell lines is presented . -
pubmed
Seven established
human glioblastoma - derived cell lines were assayed for the presence of
TR with antibody - coated magnetic microspheres ( immunobeads ) . -
pubmed
The immunobeads bound to
glioblastoma cells in the presence of
human anti - TR monoclonal antibodies to a significantly greater degree than to control cell lines ( P & lt ; 0.0001 ) . -
pubmed
A
9L rat gliosarcoma cell line was used as a nonhuman control and did not demonstrate
TR expression by either the immunobead assay or immunocytochemistry . -
pubmed
First
COMT inhibitor approved for
Parkinson ' s disease . -
pubmed
This relative resistance to
HIV-1 infection did not extend to
T cell line - adapted or syncytium - inducing ( SI ) primary viral isolates , was restricted by the
envelope glycoprotein , and was associated with an increased production of the
C - C chemokines RANTES ,
MIP-1alpha , and
MIP-1beta . -
pubmed
Resistance to
infection and the high production of
beta chemokines were characteristic of every
CD4 + lymphocyte clone from the exposed - uninfected subjects . -
pubmed
We have now identified the mechanism underlying this in vitro and in vivo resistance to
infection : These individuals have inherited a homozygous 32 - bp nucleotide deletion ( delta32 ) within the gene encoding the coreceptor for primary NSI isolates of
HIV-1 (
CCR5 ) . -
pubmed
Twelve patients infected with the
human immunodeficiency virus (
HIV ) and with
CD4 cell counts below 100 cells / microliter received
fluconazole daily ( 200 mg ; five
patients ) or weekly ( 400 mg ; seven patients ) for fungal prophylaxis during a 6 - month period . -
pubmed
METHODS : A DNA sequence encoding the ribozyme gene was incorporated into a eukaryotic expression vector (
pH beta Apr-1 neu ) and transfected into the
human breast carcinoma cell line
MCF-7 / Adr , which is resistant to
adriamycin and expresses the MDR phenotype . -
pubmed
CONCLUSIONS : We conclude that
caspase-3 - mediated apoptosis causes extensive lymphocyte apoptosis in
sepsis and may contribute to the impaired immune response that characterizes the disorder . -
pubmed
Analgesic profile of the
nicotinic acetylcholine receptor agonists ,
( + ) - epibatidine and
ABT-594 in models of persistent inflammatory and
neuropathic pain . -
pubmed
Pathogenicity of thermolabile
methylenetetrahydrofolate reductase for
vascular dementia . -
pubmed
To elucidate the specific role of the TT genotype of
MTHFR in the development of
cerebral infarction with and without
cognitive impairment , we determined the prevalence of
hyperhomocyst ( e ) inemia and the C677 T genotypes of
MTHFR in 143
patients with
vascular dementia , 122
patients with
cerebral infarction , and 217 healthy subjects matched for age and sex . -
pubmed
Taken together , these findings indicate a possible role of
MTHFR TT genotype combined with
hyperhomocyst ( e ) inemia in the pathogenesis of
vascular dementia . -
pubmed
Similar to the relationship between
homocystinuria due to severe
MTHFR deficiency and severe
cystathionine beta - synthase deficiency , the TT genotype of
MTHFR in hyperhomocyst(e)inemic subjects is differentiated from the cases of the TT genotype without
hyperhomocyst ( e ) inemia or hyperhomocyst(e)
inemia without the TT genotype in the development of
cerebrovascular disease . -
pubmed
Platelet aggregation in response to
ADP ,
collagen , and
PGE1 was assessed , using optical aggregometry . -
pubmed
Addition of
PGE1 prior to addition of an agonist inhibited
platelet aggregation in a concentration - dependent manner , whereas addition of
PGE1 4 minutes after addition of
ADP resulted in partial reversal of aggregation and
fibrinogen binding . -
pubmed
CONCLUSIONS AND CLINICAL RELEVANCE : A high concentration of
sodium citrate in blood samples decreases plasma concentration of ionized
calcium , resulting in reduced
platelet aggregation and
fibrinogen binding . -
pubmed
Despite some expression of
folate receptor alpha in
human mesothelioma cells , internalization of
methotrexate is predominantly carrier mediated . -
pubmed
OBJECTIVE : As a response to a published report documenting some expression of
folate receptor alpha in
human mesothelioma , studies were carried out examining the role of this receptor versus that of the reduced
folate carrier in the internalization of
folate analogs in this
neoplasm . -
pubmed
Gene - expression analysis revealed prominent expression of the
folate receptor in some but not all
mesothelioma cell lines , and in only one case was expression of this receptor gene greater than expression of the reduced
folate carrier gene . -
pubmed
CONCLUSION : In view of the ongoing reduced
folate carrier - mediated internalization that occurs in
mesothelioma cells , these results would seem to argue against a role for the
folate receptor in the internalization and cellular pharmacokinetics of
methotrexate and other classic
folate analogs in this
neoplasm . -
pubmed
Cytokines , especially
TNF alpha , produced from macrophages / Kupffer cells , play a role in the induction of liver cell
necrosis and apoptosis . -
pubmed
It suggested that liver - associated T lymphocytes are involved in the inflammatory process associated with
alcohol related
liver injury through increased
cytokine secretion (
TNF alpha ) . -
pubmed
OBJECTIVES : To review the state of the art relating to
protein S deficiency as a risk factor for
thrombosis and to make recommendations regarding the use of
protein S measurements in the assessment of
thrombotic risk in individual patients and families . -
pubmed
CONCLUSIONS : Consensus was reached on 16 recommendations for the use of
protein S assays in the assessment of
thrombotic risk in individuals and families . -
pubmed
[ Anti -
IgE ( Omalizumab ): a hope in the treatment of
allergic diseases ] . -
pubmed
Involvement of the anterior pretectal nucleus in the control of persistent
pain : a behavioral and
c - Fos expression study in the
rat . -
pubmed
In this study we used behavioral tests ( incisional
pain and carrageenan - induced inflammatory
pain ) and
c - Fos expression changes to examine the involvement of the APtN in the control of persistent
pain in
rats . -
pubmed
Low
adiponectin levels predict
type 2 diabetes in Mexican children . -
pubmed
[ The expression of
GABA - A receptor subunit alpha1 beta1 gamma2 mRNA in hepatic
encephalopathic rats ] . -
pubmed
The relationship between
insulin resistance assessed by HOMA - IR and serum
osteoprotegerin levels in
obesity . -
pubmed
AIM : We investigated the relationship between
insulin resistance and serum
osteoprotegerin (
OPG ) levels in healthy obese
subjects and healthy lean controls . -
pubmed
We used the homeostasis model assessment for
insulin resistance ( HOMA - IR ) index as the index of
insulin resistance . -
pubmed
RESULTS : Obese
subjects with increased
insulin resistance ( Group III ) had lower
OPG values than other groups ( 11.88+/-7.43 pg / ml , 16.39+/-6.39 pg / ml , 17.37+/-9.61 pg / ml , and 18.1+/-6.65 pg / ml , respectively ; Group I versus Group III p = 0.036 ; Group III versus Group IV p = 0.012 ) . -
pubmed
In conclusion ,
insulin resistance in
obesity is associated with decreased serum
OPG levels and increased
fibrinogen levels . -
pubmed
The relationship between serum
OPG levels and HOMA - IR may provide an insight into
vascular endothelial dysfunction in
obesity . -
pubmed
Increased expression of
plasma and cell surface co - stimulatory molecules CTLA-4 ,
CD28 and
CD86 in adult
patients with
allergic asthma . -
pubmed
To investigate whether there is altered expression and the clinical significance of soluble co - stimulatory molecules in
asthmatic patients , plasma concentrations of
sCTLA-4 ,
sCD28 ,
sCD80 and
sCD86 in 51 adult allergic
asthmatic adults with or without
steroid treatment , and 35 sex- and age - matched control subjects were measured by enzyme - linked immunosorbent assay ( ELISA ) . -
pubmed
Results showed that the plasma
sCTLA-4 concentration was significantly higher in all
asthmatic patients while
sCD28 and
sCD86 concentrations were significantly higher in
steroid and non -
steroid treated
asthmatic patients , respectively , compared with control subjects ( all P & lt ; 0.01 ) . -
pubmed
Significantly increased cell surface expression of
CD28 but not
CTLA-4 on PBMC was found in
asthmatic patients compared with controls ( P & lt ; 0.05 ) . -
pubmed
Serum total
IgE concentration correlated positively and significantly with
sCTLA-4 and
sCD28 concentrations in
allergic asthmatic patients ( both P & lt ; 0.05 ) . -
pubmed
Osteoclasts from
patients with
autosomal dominant osteopetrosis type I caused by a T253I mutation in
low - density lipoprotein receptor - related protein 5 are normal in vitro , but have decreased resorption capacity in vivo . -
pubmed
Autosomal dominant osteopetrosis type I (
ADOI ) is presumably caused by gain - of - function mutations in the
LRP5 gene . -
pubmed
To investigate the effect of the T253I mutation in
LRP5 on osteoclasts , we isolated CD14 + monocytes from
ADOI patients and assessed their ability to generate osteoclasts when treated with
RANKL and
M - CSF compared to that of age- and sex - matched control osteoclasts . -
pubmed
Cerebrotendinous xanthomatosis (
CTX ) is an
autosomal recessive lipid storage disease caused by a
deficiency of the mitochondrial enzyme 27 - sterol hydroxylase (
CYP27 ) . -
pubmed
Volunteers were questioned about their
bleeding history and the following tests were performed : complete blood count ,
prothrombin time / international normalized ratio , activated partial
thromboplastin time , platelet function analysis , and
platelet aggregation using standard turbidimetric methodology . -
pubmed
The red - haired volunteers reported significantly more
bruising , but there were no significant differences between the red - haired and dark - haired groups in
hemoglobin concentration , platelet numbers ,
prothrombin time / international normalized ratio , or activated partial
thromboplastin time . -
pubmed
Previously , we reported that
TTSS1 is involved in the
cytotoxicity of the RIMD2210633 strain against
HeLa cells . -
pubmed
The
cytotoxicity to
HeLa cells was related to one of the newly identified secreted proteins encoded by
VP1680 . -
pubmed
Aberrant methylation of
RASGRF2 and
RASSF1A in
human non - small cell lung cancer . -
pubmed
RASSF1A , regarded as a TSG , has been extensively studied in
lung cancer and other
malignant tumors , whereas
RASGRF2 has only been reported to possibly play a role in the pathogenesis of
pancreatic cancer cell lines . -
pubmed
The aims of our study were to i ) determine the methylation profile of
RASGRF2 and ii ) compare the methylation profiles of
RASGRF2 with
RASSF1A in
lung cancer . -
pubmed
We examined
RASGRF2 expression by reverse transcription PCR and aberrant methylation of
RASGRF2 by methylation - specific PCR in
lung cancer cell lines . -
pubmed
Loss of
RASGRF2 expression was presented in 36 %
lung cancer cell lines while aberrant methylation of
RASGRF2 was present in 30 % ( 3/10 )
non - small cell lung cancer (
NSCLC ) cell lines and in 25 % ( 1/4 )
small cell lung cancer (
SCLC ) cell lines . -
pubmed
Among primary
NSCLC ,
RASGRF2 and
RASSF1A methylation was observed in 34 % ( 39/114 ) and 39 % ( 44/114 ) of cases respectively , while it was observed in only 7 % ( 4/57 ) and none of the corresponding
non - malignant lung tissue . -
pubmed
Frequent methylation and silencing of
RASGRF2 in
tumor cells may play an important role , different from that of
RASSF1A , in the carcinogenesis of
NSCLC . -
pubmed
Of 632 women , aged 70 - 79 yr , 14.1 % of women were
anemic (
hemoglobin & lt;120 g / L ) . -
pubmed
An increase in loge
selenium was associated with a reduced risk of
anemia ( odds ratio per 1 SD increase = 0.63 , 95 % confidence interval = 0.47 - 0.84 ) , adjusting for age , education ,
chronic diseases ,
iron status , and serum
interleukin-6 . -
pubmed
IL-23 plays crucial roles in both immunity against pathogens and
autoimmunity against self . -
pubmed
In univariate analysis , leukocytes and
CRP levels were associated with
MVO , whereas pre -
infarction angina and prior medication by
aspirin or
calcium channel antagonist appeared protective . -
pubmed
Microvascular obstruction intensity positively correlated with baseline
inflammation status assessed by
C - reactive protein and leukocytes ( rho=0.43 and rho=0.44 ; p=0.003 ) , the peak of
CK ( rho=0.56 ; p=0.01 ) or
Troponin I ( rho=0.59 ; p=0.01 ) and negatively correlated with LVEF ( rho=-0.44 ; p=0.002 ) . -
pubmed
tPA levels increased in
FMF patients (
tPA levels of group 1 , 2 and 3 were 12.6 , 13.2 and 9.7 ng / ml , respectively ; p = 0.01 ) . -
pubmed
Prolongation of PT and differences in
tPA and
P - selectin levels suggest that
hypercoagulability may have a role in the etiopathogenesis of
FMF . -
pubmed
It may be possible to use
PAI-1 as a marker for the attacks of
FMF . -
pubmed
CXCR5- and
CCR7 - dependent lymphoid neogenesis in a
murine model of chronic antigen - induced
arthritis . -
pubmed
The aim of this study was to establish a
murine model of
chronic arthritis in which the development of tertiary lymphoid tissue , a hallmark of
human RA , is locally induced , and to characterize the roles of the homeostatic
chemokine receptors CXCR5 and
CCR7 in this process . -
pubmed
Disease pathology was assessed up to 9 months in wild - type ,
CXCR5 - deficient , and
CCR7 - deficient
mice by determination of knee joint swelling and cellular and humoral immune responses , as well as by histologic analysis of
arthritic knee joints . -
pubmed
Analysis of the initiation and progression of
AIA in wild - type ,
CXCR5-/- , and
CCR7-/-
mice revealed a reduction of acute inflammatory parameters in both knockout strains as well as significantly reduced joint destruction in
CXCR5-/-
mice . -
pubmed
Cardiac troponin I as prognostic marker in
heart failure patients discharged from emergency department . -
pubmed
Despite evidence that
cardiac troponin I (
cTnI ) identifies patients with advanced
heart failure (
HF ) at risk of death , data on heterogeneous
HF populations are scarce . -
pubmed
Our purpose was to verify and analyze the prognostic role of
cTnI in acute
HF patients admitted to the emergency department . -
pubmed
cTnI was detected in 45.5 % of
HF patients . -
pubmed
Viral and host correlates of serum
resistin in simian
AIDS . -
pubmed
Resistin is an adipocytokine with a proposed dual role in metabolism and
inflammation . -
pubmed
This study utilizes the
simian immunodeficiency virus ( SIV ) model of
HIV /
AIDS to investigate changes in serum
resistin levels following dietary intervention and
SIV infection and determine associations with measures of body composition and disease severity . -
pubmed
Resistin levels , body composition ( n = 34 ) , and
insulin resistance ( n = 16 ) were determined in healthy
rhesus macaques . -
pubmed
In healthy macaques consuming a standard diet ,
resistin levels correlated positively with total fat mass ( r = 0.49 ; p & lt ; 0.01 ) and tissue fat percent ( r = 0.53 ; p & lt ; 0.01 ) but failed to associate with measures of
insulin resistance . -
pubmed
Serum levels of
MCP-1 and
sTNF RII demonstrated no correlation with
resistin in normal
animals on a standard diet , while a significant positive correlation was observed following
SIV infection ( r = 0.52 ; p & lt ; 0.0001 and r = 0.59 ; p & lt ; 0.0001 , respectively ) . -
pubmed
Findings indicate a fundamental difference in the relationship between
resistin and body composition following
SIV infection and suggest that elevations in
resistin parallel measures of disease severity including loss of body fat and viral replication . -
pubmed
Recessive
hereditary methemoglobinemia : two novel mutations in the
NADH - cytochrome b5 reductase gene . -
pubmed
Relation between degree of
weight loss after bariatric surgery and reduction in
albuminuria and
C - reactive protein . -
pubmed
Improvement in
albuminuria and high - sensitivity
C - reactive protein (
hs - CRP ) has also been reported . -
pubmed
We investigated , at a weight control center in a community hospital setting , the relation between degree of surgical weight loss and reduction in the cardiovascular risk markers ,
albuminuria and hs -
CRP . -
pubmed
CONCLUSION : The results of our study have shown that
obese adults experience a reduction in
albuminuria and hs -
CRP after bariatric surgery , with a greater reduction in hs -
CRP observed with more surgical
weight loss . -
pubmed
STUDY DESIGN : To investigate if milk enzyme activities and the inflammatory
interleukin 8 (
IL-8 ) level are increased in
women with
SCM , we measured
sodium ,
potassium ,
NAGase ,
LDH , AcP ,
AP , and
IL-8 in breastmilk samples collected at 2 months postpartum from 797
women in Guinea - Bissau , West Africa . -
pubmed
BACKGROUND : Studies have suggested that
vitamin D may be important for both
insulin sensitivity and
insulin secretion , and that supplementation with
vitamin D may subsequently prevent development of
type 2 diabetes . -
pubmed
METHODS : Thirty - six
subjects with
type 2 diabetes , treated with
metformin and bed - time
insulin , were randomised to supplementation with
cholecalciferol ( 40,000 IU per week ) versus placebo for 6 months . -
pubmed
Estrogen receptor alpha (
ER alpha ) is a ligand - regulated transcription factor with a broad range of physiological functions and one of the most important classifiers in
breast cancer . -
pubmed
miR-22 overexpression leads to a reduction of
ER alpha levels , at least in part by inducing mRNA degradation , and compromises
estrogen signaling , as exemplified by its inhibitory impact on the
ER alpha - dependent proliferation of
breast cancer cells . -
pubmed
Update on phase II studies of
erythropoietin in
acute myocardial infarction . -
pubmed
Rationale and design of Exogenous
erythroPoietin in
Acute Myocardial Infarction : New Outlook aNd Dose Association Study ( EPAMINONDAS ) . -
pubmed
Erythropoietin (
Epo ) is a hematopoietic hormone produced mainly by the kidneys in response to
hypoxia . -
pubmed
Exogenous
erythroPoietin in
Acute Myocardial Infarction : New Outlook aNd Dose Association Study ( EPAMINONDAS , EudraCTno . -
pubmed
200500485386 ) is one of four ongoing randomized controlled trials , each testing the effects of
Epo in & gt;or=100
patients with
STEMI . -
pubmed
EPAMINONDAS is a multicenter , prospective , double - blind , placebo - controlled , dose - finding study assessing intravenous moderate doses of
human recombinant
Epo (
epoietin - alpha , 100 or 200 IU / kg / die ) versus placebo , given on the first 3 days , in 102
patients with first
ST - segment elevation myocardial infarction . -
pubmed
The results of current phase II studies will help define the safety / efficacy profile of
Epo for
patients with
STEMI . -
pubmed
Functional autoantibodies against
serpin E2 in
rheumatoid arthritis . -
pubmed
Levels of anti - serpin
E2 autoantibodies in serum and synovial fluid from
patients with
RA ,
osteoarthritis (
OA ) ,
psoriatic arthritis , and
ankylosing spondylitis , and/or from healthy
individuals were assessed by enzyme - linked immunosorbent assay . -
pubmed
Serpin E2 was overexpressed in
RA synovial tissues as compared with
OA synovial tissues . -
pubmed
Significantly higher levels of
anti - serpin E2 autoantibodies were present in samples of synovial fluid ( 28 % ) and serum ( 22 % ) from
RA patients as compared with
OA patients ( 0 and 6 % , respectively ) or with healthy
individuals ( 6 % of sera ) . -
pubmed
Most importantly ,
anti - serpin E2 autoantibodies isolated from
RA sera reversed the inhibitory activity of
serpin E2 by 70 % . -
pubmed
Since
anti - serpin E2 autoantibodies interfere with the inhibitory activity of
serpin E2 toward
serine proteases , they might facilitate the joint destruction in
RA . -
pubmed
Reduction of the activity of the purified
lectin after oxidation by
H2O2 , with remarkable fluorescence quenching , may suggest potential role for
galectin-1 in free radical - induced , oxidative stress - mediated
cardiovascular disorders . -
pubmed
Expression and methylation status of the
Syk gene in
cervical carcinoma . -
pubmed
Decrease or loss of
Syk expression has been associated with a malignant phenotype and poor prognosis in a variety of
cancers . -
pubmed
This study aimed to determine the precise role of
Syk in
cervical cancer . -
pubmed
METHODS : Methylation - specific PCR ( MSP ) and RT - PCR were utilized to analyze the methylation status and
Syk mRNA expression in tissue samples from 20
normal controls , 50
CIN patients and 60
cervical cancer patients . -
pubmed
RESULTS :
Syk expression was detected in all 20
normal cervical tissues , as well as in all 18 CIN1 samples . -
pubmed
Syk expression was found in 18 of 32 ( 56 % ) of
CIN2/3 samples . -
pubmed
CONCLUSION : The results indicate a potential link between the loss of
Syk expression and cervical
carcinogenesis . -
pubmed
Metabolic syndrome criteria had the highest sensitivity for predicting fasting
insulin ( 40 - 70 % ) , followed by
uric acid ( 31 - 54 % ) ,
hsCRP ( 13 - 31 % ) , and HbA1c ( 7 - 21 % ) . -
pubmed
Rho - kinase /
nuclear factor - kappabeta /
angiotensinogen axis in
angiotensin II - induced
renal injury . -
pubmed
Glycosaminoglycan storage in neuroanatomical regions of
mucopolysaccharidosis I dogs following intrathecal recombinant
human iduronidase . -
pubmed
Intrathecal ( IT ) recombinant
human alpha - l - iduronidase (
rhIDU ) has been shown to reduce mean brain glycosaminoglycans ( GAGs ) to normal levels in
mucopolysaccharidosis I (
MPS I )
dogs . -
pubmed
[ Association of
ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with
cerebral infarction ] . -
pubmed
OBJECTIVE : To study the association of
ITGA9 gene rs189897 and rs2212020 polymorphisms and its haplotype with the occurrence of
cerebral infarction (
CI ) . -
pubmed
METHODS : In the venous blood samples from 250
patients with
cerebral infarction and 250 control samples , the genotypes of rs189897 and rs2212020 of
ITGA9 gene were identified by PCR - sequencing . -
pubmed
CONCLUSION : rs189897 and rs2212020 in
ITGA9 gene are closely related to CI , and its A - C haplotype is the protective factor against
CI . -
pubmed
Serum levels of
vascular epithelial growth factor (
VEGF ) , which is considered to be a causative factor of endothelial lesions in
POEMS syndrome , were not elevated throughout the course of this case . -
pubmed
Immunoglobulin M nephropathy in a
patient with systemic lupus . -
pubmed
Immunoglobulin M ( IgM ) nephropathy is an uncommon
glomerular disease characterized by
IgM deposits in the mesangium . -
pubmed
Renal biopsy revealed
IgM nephropathy , with no clear evidence of
lupus nephritis . -
pubmed
Presently , recombinant
tissue plasminogen activator is the only approved drug for the management of
acute ischemic stroke . -
pubmed
Twenty four hours after
MCAo , motor performance was assessed and the
animals were euthanized for estimation of brain
malondialdehyde ,
glutathione ,
myeloperoxidase and
nitric oxide levels . -
pubmed
T cells that target
carcinoembryonic antigen eradicate orthotopic
pancreatic carcinomas without inducing
autoimmune colitis in
mice . -
pubmed
Carcinoembryonic antigen (
CEA ) is highly expressed on the surface of
pancreatic adenocarcinoma cells ; we investigated the effects of cytolytic T cells that recognize
CEA in a
mouse model of
pancreatic carcinoma . -
pubmed
METHODS : Immune - competent
mice that expressed the
CEA transgene ( CEAtg ) in the intestinal and pulmonary tracts were given intrapancreatic injections of
Panc02 CEA(+ ) cells ( express
CEA and click beetle luciferase ) and
tumors were grown for 10 days . -
pubmed
RESULTS : Injection of the anti -
CEA CAR T cells reduced the size of
pancreatic tumors to below the limit of detection in all
mice and produced long - term
tumor eradication in 67 % of
mice . -
pubmed
T cells also eradicated
CEA(+ )
fibrosarcoma cells injected 45 days later . -
pubmed
CONCLUSIONS : Injection of T cells that target
CEA can eradicate
tumors grown from
CEA(+ )
pancreatic carcinoma cells in the pancreas of CEAtg
mice without autoimmune effects . -
pubmed
Collectively , our data strongly suggest a critical role for
CD4(+ ) T help in multiple phases of
AdV - stimulated CTL responses , and could partially explain certain failures in
AdV - based immunization trials targeting malignant
tumors and
chronic diseases that are often associated with compromised
CD4(+ ) T cell population and function . -
pubmed
Monocytosis at diagnosis was associated with lymphocyte count , deletions of chromosomes 17p and 11q , the extent of
IgVH somatic hypermutation and Binet stage . -
pubmed
RESULTS : Four - month oral
resveratrol administration to
diabetic rats ( 5 mg / kg / day ) alleviated the reduction of cardiac antioxidant enzymes activities ( 3.88 + - 0.48 vs. 1.49 + - 0.43 U , p & lt ; 0.05 for
superoxide dismutase , and 2.72 + - 0.26 vs. 1.18 + - 0.19 nmol / min / mL , p & lt ; 0.05 for
catalase ) and the enhancement of cardiac oxidative markers ( 5.01 + - 0.37 vs. 7.23 + - 0.51 ng , p & lt ; 0.05 for
8 - isoprostane , 6.03 + - 0.87 vs. 8.49 + - 0.52 mumol , p & lt ; 0.05 for
nitrite /
nitrate , and 0.44 + - 0.03 vs. 0.59 + - 0.04 , p & lt ; 0.05 for
oxidized / reduced glutathione ratio ) ,
nuclear factor kappa B activity ( 0.37 + - 0.09 vs. 0.60 + - 0.11 , p & lt ; 0.05 ) and apoptosis rate ( 0.98 + - 0.28 vs.1.63 + - 0.16 , p & lt ; 0.05 ) . -
pubmed
The use of incretin - based therapies , such as the
dipeptidyl peptidase-4 (
DPP-4 ) inhibitors and
glucagon - like peptide-1 (
GLP-1 ) analogs , is growing in
patients with
T2DM , due to their efficacy and tolerability profiles . -
pubmed
As renal safety is a key factor when choosing treatment options to manage
patients with
T2DM , drugs that are suitable for use in
patients with varying degrees of
renal impairment without a requirement for dose adjustment , such as the
DPP-4 inhibitor
linagliptin , are of particular use . -
pubmed
HLA - DPB1 * 04:01 allele is associated with
non - obstructive azoospermia in Japanese patients . -
pubmed
Previous studies reported that specific alleles and single
nucleotide polymorphisms ( SNPs ) in the human leukocyte antigen (
HLA ) region were associated with
NOA in East Asians . -
pubmed
We attempt to expand upon previous findings by genotyping more
HLA genes and to replicate SNP associations by focusing on Japanese
NOA patients . -
pubmed
HLA typing of six genes (
HLA - A , -B , -C , -DRB1 , -DQB1 , and -
DPB1 ) was done on 355
NOA patients using SSO - Luminex assay while genotyping of two previously reported SNPs ( rs498422 and rs3129878 ) was done on 443 patients and 544 fertile males using TaqMan assay . -
pubmed
We found that HLA - DPB1 * 04:01 [ corrected p value , P(c ) 7.13 x 10(-6 ) ; odds ratio ( OR ) 2.52 ] ,
DRB1 * 13:02 ( P(c ) 4.93 x 10(-4 ) , OR 1.97 ) , DQB1 * 06:04 ( P(c ) 8.94 x 10(-4 ) , OR 1.91 ) and rs3129878 ( p value 3.98 x 10(-4 ) ; OR 1.32 ) showed significant association with
NOA , however , these loci are in linkage disequilibrium with each other . -
pubmed
The conditional logistic regression tests showed that
DPB1 * 04:01 is independently associated with
NOA , confirming the involvement of the
HLA region in the etiology of
NOA in Japanese patients . -
pubmed
Comment on " changes and regulation of the
C5a receptor on neutrophils during
septic shock in
humans " . -
pubmed
In mid-2011 , the addition of direct - acting antiviral agents ( DAAs)-the
protease inhibitors
boceprevir (
Victrelis , Merck ) and
telaprevir (
Incivek ,
Vertex)-to
pegylated interferon alpha-2a / b and
ribavirin revolutionized the treatment of
HCV infection by increasing cure rates across all
fibrosis scores in patients with genotype 1
HCV infection . -
pubmed
Findings from patients with
dry eye have implicated defects in innate immunity (
Toll - like receptors ,
S100A and resident antigen - presenting cells ) ,
cytokines ,
chemokines and T helper ( TH)-cell subsets ( including TH1 and TH17 ) in disease pathogenesis . -
pubmed
Tissue damage is treated by inhibiting
matrix metalloproteinases . -
pubmed
Breast cancer genes : looking for
BRACA 's lost brother . -
pubmed
AMP - activated protein kinase (
AMPK ) is a critical regulator of cellular metabolism and plays an important role in
diabetes ,
cancer , and
vascular disease . -
pubmed
In the heart ,
AMPK activation is an essential component of the adaptive response to cardiomyocyte stress that occurs during
myocardial ischemia . -
pubmed
During
ischemia - reperfusion ,
AMPK activation modulates
glucose and
fatty acid metabolism , mitochondrial function , endoplasmic reticulum ( ER ) stress , autophagy , and apoptosis . -
pubmed
Pharmacological activation of
AMPK prevents
myocardial necrosis and contractile dysfunction during
ischemia - reperfusion and potentially represents a cardioprotective strategy for the treatment of
myocardial infarction . -
pubmed
This review discusses novel mechanisms of
AMPK activation in the ischemic heart , the role of endogenous
AMPK activation during
ischemia , and the potential therapeutic applications for
AMPK - directed therapy . -
pubmed
Trametinib radiosensitises
RAS- and
BRAF - mutated
melanoma by perturbing cell cycle and inducing senescence . -
pubmed
By immunohistochemistry the expression of
Fas receptor and
Fas - L was higher in the skin of
lupus patients compared with controls . -
pubmed
We also noted differences in
Fas - L , -
Fas , and -
Bax proteins expression intensity in
discoid lupus erythematosus patients in the epidermis , and hair follicles . -
pubmed
CONCLUSIONS :
Fas and
Fas - L are expressed similarly in
LP and
DLE . -
pubmed
Lumbar Disc Degeneration is Facilitated by MiR-100 - Mediated
FGFR3 Suppression . -
pubmed
BACKGROUND / AIMS : The pathogenesis of
lumbar disc degeneration (
LDD ) involved activation of
matrix metalloproteinase 13 (
MMP13 ) by differential expression of
fibroblast growth factor receptor 1 (
FGFR1 ) and
FGFR3 . -
pubmed
METHODS : We examined the
FGFR1 and
FGFR3 levels and microRNAs ( miRNAs ) levels in the resected
LDD discs , compared to the traumatized , non - LDD discs . -
pubmed
RESULTS : The levels of
FGFR1 and miR-100 were significantly higher , while the levels of
FGFR3 were significantly lower , in
LDD discs , compared to the control non - LDD discs . -
pubmed
CONCLUSION : miR-100 may activate
MMP13 through 3'UTR - suppressoin of
FGFR3 mRNA to facilitate development of
LDD . -
pubmed
Possible Role of
HER-2 in the Progression of
Prostate Cancer from Primary
Tumor to
Androgen Independence . -
pubmed
BACKGROUND : The expression of
HER-2 in
prostate cancer has been linked to disease progression . -
pubmed
We analysed the presence of
HER-2 expression in primary
tumors in
men undergoing radical prostatectomy , its association with clinical and pathological findings , and its expression in secondary circulating prostate cells ( CPCs ) during follow up , as well as links with biochemical failure and the effects of
androgen blockade . -
pubmed
HER-2 expression in the primary
tumor was assessed using the HercepTest , CPCs were identified from blood samples using standard immunocytochemistry with anti -
PSA and positive samples with the HercepTest to determine
HER-2 expression . -
pubmed
HER-2 was expressed in 20.8 % of primary
tumors ; it was associated with vascular infiltration and older age , but not with other clinical pathological findings . -
pubmed
Some 40.3 % of men had secondary
CPCs detected , of which 38 % expressed
HER-2 . -
pubmed
After
androgen blockade , men with
HER-2 ( + ) positive secondary
CPCs had a higher frequency of disease progression to castrate resistant disease . -
pubmed
CONCLUSIONS :
HER-2 plays a dual role in the progression of
prostate cancer ; firstly it may increase the potential of
tumor cells to disseminate from the primary
tumor via the blood by increasing vascular infiltration . -
pubmed
NOD2 Loss - of - Function Mutations and Risks of
Necrotizing Enterocolitis or Focal Intestinal Perforation in Very Low - birth - weight Infants . -
pubmed
BACKGROUND :
NOD2 loss - of - function mutations , that is , R702W [ rs2066844 ] , G908R [ rs2066845 ] , and Leu1007fsinsC [ rs5743293 ] , have been linked to
inflammatory bowel diseases . -
pubmed
We assessed the effect of the
NOD2 gene variants on the risk for major morbidities of the gastrointestinal tract , that is ,
NEC /
FIP requiring surgery in multivariable logistic regression analyses . -
pubmed
RESULTS : In the whole cohort of VLBW infants , carriers of & gt;= 2
NOD2 variant alleles had an increased risk for
NEC requiring surgery ( odds ratio [ OR ] , 3.57 ; 95 % confidence interval [ CI ] , 1.27 - 10.04 ; P = 0.03 ) and
NEC or
FIP requiring surgery ( OR , 3.81 ; 95 % CI , 1.70 - 8.51 ; P = 0.004 ) as compared with wild - type genotypes . -
pubmed
In a multivariable logistic regression analysis including gestational age , birth weight , gender , multiple birth , and inborn delivery , the association between & gt;= 2
NOD2 variant alleles and NEC surgery ( OR , 4.14 ; 95 % CI , 1.41 - 12.12 ; P = 0.009 ) , FIP surgery ( OR , 3.50 ; 95 % CI , 1.02 - 12.04 ; P = 0.047 ) , and
NEC or FIP surgery ( OR , 4.10 ; 95 % CI , 1.74 - 9.73 ; P = 0.001 ) proved to be independent . -
pubmed
Although probiotics had a protective effect on
NEC and
NEC or
FIP requiring surgery , the
NOD2 variants had no significant impact in this subgroup . -
pubmed
CONCLUSIONS : VLBW infants carrying & gt;= 2
NOD2 genetic risk factors of
inflammatory bowel disease in adults have an increased risk for severe
gastrointestinal complications , such as
NEC requiring surgery . -
pubmed
BACKGROUND : The
phosphodiesterase-5 inhibitor
sildenafil has been shown to attenuate delayed
cerebral ischemia (
DCI ) and improve neurologic function in experimental
subarachnoid hemorrhage (
SAH ) . -
pubmed
RESULTS : Depending on the modelling approach applied ,
albumin , body surface area , neutrophil , baseline
tumour size and
tumour shrinkage measures were identified as potential prognostic factors . -
pubmed
PNMA2 , a member of the
Paraneoplastic Ma Family (
PNMA ) , was identified through expression cloning by using anti - sera from
patients with
paraneoplastic disorder . -
pubmed
Tissue expression studies showed that
PNMA2 was predominantly expressed in normal
human brain ; however , the protein was shown to exhibit abnormal expression profile as it was found to be expressed in a number of
tumour tissues obtained from paraneopalstic
patients . -
pubmed
Cost - Effectiveness Analysis of
Ugt1a1 Genotyping Before
Colorectal Cancer Treatment with
Irinotecan . -
pubmed
Adverse Effects of
Proton Pump Inhibitors in
Chronic Kidney Disease . -
pubmed
In
SEA , clinical studies are urgently needed to monitor ACT efficacy where
K13 mutations are prevalent , test whether new combinations of currently available drugs cure ACT failures , and advance new antimalarial compounds through preclinical pipelines and into clinical trials . -
pubmed
TNF - like weak inducer of apoptosis ( TWEAK ) receptor Fn14 is expressed by podocytes and
Fn14 deficiency protects from experimental
proteinuric kidney disease . -
pubmed
Increased kidney
Fn14 and
CCL21 expression was also observed in
rat proteinuric kidney disease induced by
puromycin , and was localized to podocytes . -
pubmed
The non - canonical
NFkappaB pathway should be explored as a potential therapeutic target in
proteinuric kidney disease . -
pubmed
Nuclear and extranuclear - initiated
estrogen receptor signaling crosstalk and endocrine resistance in
breast cancer . -
pubmed
There are various
ERalpha targeting agents that have been used for treatment of
ER ( + ) breast tumors . -
pubmed
The impact of direct nuclear activity of
ER is very well characterized in
ER ( + ) breast cancers and development and progression of endocrine resistance . -
pubmed
In this mini - review , we will discuss the role of nuclear and extra - nuclear
ER signaling and how they relate to therapy resistance in
breast cancer . -
pubmed
Safety Studies in
Tumor and Non - Tumor - Bearing
Mice in Support of Clinical Trials Using Oncolytic VSV -
IFNbeta - NIS . -
pubmed
Oncolytic VSV -
IFNbeta - NIS is selectively destructive to
tumors . -
pubmed
Clinical translation of VSV -
IFNbeta - NIS is underway in companion
dogs with
cancer and in
human patients with relapsed
hematological malignancies and
endometrial cancer . -
pubmed
Asymptomatic
CMV Replication During Early
Human Immunodeficiency Virus ( HIV ) Infection Is Associated With Lower
CD4 /
CD8 Ratio During
HIV Treatment . -
pubmed
BACKGROUND : A low
CD4 /
CD8 ratio in
human immunodeficiency virus ( HIV )- infected individuals is associated with
inflammation and higher risk of non - AIDS morbidity and mortality . -
pubmed
In this study , we investigated the effect of subclinical cytomegalovirus (
CMV ) and
Epstein - Barr virus (
EBV ) replication on
CD4 + and
CD8 + T - cell dynamics when antiretroviral therapy ( ART ) is started during early
infection . -
pubmed
CONCLUSIONS : Subclinical
CMV replication in blood cells during early
HIV infection and younger age were associated with lower
CD4 /
CD8 ratios during suppressive ART . -
pubmed
NSP4 antibody levels in
rotavirus gastroenteritis patients with
seizures . -
pubmed
BACKGROUND : Rotavirus
nonstructural protein 4 (
NSP4 ) has been suggested as a pathogen of
rotavirus - associated seizures . -
pubmed
We investigated pre - existing serum antibodies against
NSP4 and
VP6 ( the most highly immunogenic rotavirus protein ) in
patients with
rotavirus gastroenteritis and its correlation with the occurrence of
seizures . -
pubmed
METHODS : With an enzyme - linked immunosorbent assay ,
IgG and
IgA titers against
NSP4 ( genotype [ A ] and [ B ] ) and
VP6 were measured in acute - phase sera of 202
children aged 0.5 - 6.0 years with
rotavirus gastroenteritis . -
pubmed
Age , sex , hospital stay , presence of
fever , white blood cell counts ,
C - reactive protein , vaccine status ,
IgG /
IgA titers for
VP6 , and
IgA titers for both
NSP4s did not differ between the groups . -
pubmed
The
seizure group showed a lower level of
IgG against
NSP4 [ A ] ( 184.5 vs. 163.0 U / mL ; P = 0.03 ) and
NSP4 [ B ] ( 269.0 vs. 196.0 U / mL ; P = 0.02 ) . -
pubmed
Even after adjusting these factors , anti -
NSP4 [ A ]
IgG ( OR 2.56 per 100 U / mL increment ; 95 % CI , 1.20 - 5.26 , P = 0.01 ) and anti -
NSP4 [ B ]
IgG ( OR 1.51 per 100 U / mL - increment ; 95 % CI , 1.04 - 2.22 , P = 0.03 ) were independently associated with protection against
seizures . -
pubmed
CONCLUSIONS : Serum anti -
NSP4 IgG might protect
rotavirus - associated seizures . -
pubmed
Using
tuberous sclerosis complex to understand the impact of
MTORC1 signaling on mitochondrial dynamics and mitophagy in neurons . -
pubmed
Constitutive activation of the
MTOR pathway is a key feature of defects in the
tuberous sclerosis complex and other genetic
neurodevelopmental diseases , collectively referred to as MTORopathies . -
pubmed
Erratum to : Usefulness of combining admission
brain natriuretic peptide (
BNP ) plus hospital discharge bioelectrical impedance vector analysis ( BIVA ) in predicting 90 days cardiovascular mortality in
patients with acute
heart failure . -
pubmed
The
ENTPD1 promoter polymorphism -860 A & gt ; G ( rs3814159 ) is associated with increased gene transcription , protein expression ,
CD39 /
NTPDase1 enzymatic activity , and
thromboembolism risk . -
pubmed
Ectonucleoside triphosphate diphosphohydrolase 1 (
NTPDase1 ) degrades the
purines ATP and
ADP that are key regulators of
inflammation and clotting . -
pubmed
We sequenced the
ENTPD1 gene ( encoding
NTPDase1 ) in 216 subjects then assessed genotypes in 2 cohorts comprising 2213
humans to identify
ENTPD1 polymorphisms associated with
venous thromboembolism (
VTE ) . -
pubmed
Thus , the G allele of rs3176891 marks a haplotype associated with increased clotting and
platelet aggregation attributable to a promoter variant associated with increased transcription , expression , and activity of
NTPDase1 . -
pubmed
The
ENTPD1 promoter polymorphism -860 A & gt ; G ( rs3814159 ) is associated with increased gene transcription , protein expression ,
CD39 /
NTPDase1 enzymatic activity , and
thromboembolism risk . -
pubmed
Bioinformatic analysis suggested that statin - induced miRNAs functions were primarily enriched in angiogenesis ,
integrin and platelet derived growth factor signaling pathways in
UA patients . -
pubmed
Replication of rs300774 , a genetic biomarker near
ACP1 , associated with suicide attempts in patients with
schizophrenia : Relation to brain
cholesterol biosynthesis . -
pubmed
CONCLUSIONS : Our results indicate that small - scale multiregional sampling and subsequent screening of low
VAF somatic mutations might be a cost - effective strategy for identifying the majority of trunk mutations in gastric
carcinoma . -
pubmed
Glycosaminoglycan ( GAG ) enrichment is a dominant hallmark of early
CAVD , but culture of valvular interstitial cells ( VICs ) in biomaterial environments containing pathological amounts of hyaluronic acid ( HA ) or
chondroitin sulfate ( CS ) did not directly increase indicators of disease progression such as VIC activation or inflammatory
cytokine production . -
pubmed
However , HA - enriched matrices increased production of
vascular endothelial growth factor (
VEGF ) , while matrices displaying pathological levels of CS were effective at retaining lipoproteins , whose deposition is also found in early
CAVD . -
pubmed
Nucleostemin regulates proliferation and migration of
gastric cancer and correlates with its malignancy [ Retraction ] . -
pubmed
Response to stretching was remarkably reduced in a
rat model of LV
hypertrophy , which also failed to increase
titin phosphorylation . -
pubmed
Comparison of HbA1c and
glycated albumin as a control marker for newborn complications in
diabetic women in a multicentre study in Japan ( Japan
glycated albumin study group : study 2 ) . -
pubmed
Background To clarify the relationship between glycated
haemoglobin and
glycated albumin concentrations during pregnancy with neonatal outcomes , a multicentre study was conducted by the Japanese Society of
Diabetes and Pregnancy . -
pubmed
On the other hand , the frequency of neonatal complications showed higher tendency of neonatal complications in the incidence of
polycythaemia ( P = 0.094 ) and heavy - for - date ( P = 0.071 ) in the
glycated albumin & gt;=15.8 % group compared with the
glycated albumin & lt;15.8 group . -
pubmed
Conclusions For the treatment of pregnant
women with
diabetes ,
glycated albumin would be a better marker than
glycated haemoglobin . -
pubmed
However ,
glycated albumin is also affected by
obesity and
albumin , and it is desirable to make a comprehensive judgment with glycated
haemoglobin , random plasma
glucose and other glycaemic index . -
pubmed
Icariside II ameliorates
ibotenic acid - induced
cognitive impairment and apoptotic response via modulation of
MAPK pathway in
rats . -
pubmed
ICS II administrated at doses of 8 and 16 mg / kg not only rescued behavioral performance , but also protected hippocampal neurons against
neurotoxicity via suppressing the elevation of
Bax /
Bcl-2 ratio and the activation of
caspase-3 . -
pubmed
CONCLUSION : These results suggest that ICS II attenuates
IBO - induced
cognitive deficits , possibly via the regulation of
calbindin expression and the inhibition of apoptotic response . -
pubmed
In addition , the
MAPK signaling pathway is implicated in the potential mechanisms of ICS II against
IBO - induced
excitotoxicity , indicating that ICS II is a promising compound for treatment of
excitotoxicity - related diseases , including
AD . -
pubmed
Exome data analysis revealed significantly mutated genes previously linked to
SBA (
TP53 ,
KRAS ,
APC ,
SMAD4 , and
BRAF ) , recently reported potential driver genes (
SOX9 ,
ATM , and
ARID2 ) , as well as novel candidate driver genes , such as
ACVR2A ,
ACVR1B ,
BRCA2 , and
SMARCA4 . -
pubmed
Prior to
infection five animals showed positive
IFN - gamma responses to avian PPD (
PPD - A ) and four were positive in Map PCR ( IS900 ) on faeces . -
pubmed
bovis infected animals reacted as early as day 14 with sustained higher
PPD - B than
PPD - A specific
IFN - gamma responses , whereas the fourth animal ( with the strongest
PPD - A response prior to
infection ) showed sustained higher
PPD - B specific
IFN - gamma levels only a day 56 after
infection . -
pubmed
Later during
infection , positive responses were found to
ESAT-6 peptides in three infected bulls and to
CFP-10 peptides in all four infected bulls . -
pubmed
These data reveal a novel contribution of autoreactive CD8 T cells to
autoimmune disease , in part , through
CD4 follicular - like differentiation and functionality . -
pubmed
Earlier studies have shown that treatment of keratinocytes and
mouse skin with the
green tea polyphenol ( -)- epigallocatechin-3 - gallate (
EGCG ) mitigated
inflammation and increased the expression of
caspase-14 while promoting epidermal differentiation and cornification . -
pubmed
Topically applied nanoEGCG elicited a significant ( p<0.01 ) amelioration of psoriasiform pathological markers in IMQ - induced
mouse skin lesions , including reductions in ear and skin thickness ,
erythema and scales , proliferation ( Ki-67 ) , infiltratory immune cells ( mast cells , neutrophils , macrophages , and CD4 + T cells ) , and angiogenesis (
CD31 ) . -
pubmed
Importantly , a significant modulation of several
psoriasis - related inflammatory
cytokines and
chemokines was observed compared to the high dose of free
EGCG ( p<0.05 ) . -
pubmed
Chaihu - Shugan - San Decoction Modulates Intestinal Microbe Dysbiosis and Alleviates Chronic Metabolic Inflammation in
NAFLD Rats via the
NLRP3 Inflammasome Pathway . -
pubmed
We evaluate the effects of the Chaihu - Shugan - San decoction on intestinal microbe dysbiosis and
chronic metabolic inflammation via the
NLRP3 pathway in
NAFLD rats that were fed a high - fat diet . -
pubmed
In summary , the Chaihu - Shugan - San decoction modulated intestinal microbe dysbiosis , reduced fat accumulation , and alleviated inflammatory factor expression , which are all processes related to the
NLRP3 inflammasome pathway in
NAFLD rats . -
pubmed
Nuclear factor - erythroid 2 - related factor-2 (
Nrf2 ) is a key transcription factor limits the
tumor progression . -
pubmed
Meanwhile , hyper activation of
NF - kappaB transcription factors was witnessed in the
tumor cells . -
pubmed
Antagonistic activity of
BITC ,
PEITC and
SFN against
cancer was related with the direct / indirect interaction with
Nrf2 and
NF - kappaB protein . -
pubmed
We have also discussed the molecular interaction(s ) of the antagonistic effect of
BITC ,
PEITC and
SFN with
Nrf2 and
NF - kappaB to prevent
cancer . -
pubmed
Characteristics and outcomes of therapy - related
myeloid neoplasms after
peptide receptor radionuclide / chemoradionuclide therapy ( PRRT / PRCRT ) for metastatic
neuroendocrine neoplasia : a single - institution series . -
pubmed
PURPOSE :
Peptide receptor radionuclide / chemoradionuclide therapy ( PRRT / PRCRT ) is an effective therapy for
metastatic neuroendocrine neoplasia (
NEN ) , but therapy - related
myeloid neoplasms ( t -
MN ) remain of concern . -
pubmed
AQP8 and
AQP9 expression in
patients with
polycystic ovary syndrome and its association with in vitro fertilization - embryo transfer outcomes . -
pubmed
The aim of the present study was to investigate
aquaporin ( AQP ) 8 and
AQP9 expression in
patients with
polycystic ovary syndrome (
PCOS ) and its association with in vitro fertilization - embryo transfer ( IVF - ET ) outcomes . -
pubmed
A total of 45
patients with
PCOS undergoing IVF - ET ( test group ) and 50
patients with
oviduct obstruction or
ovarian cyst ( control group ) were assessed for the mRNA expression of
AQP8 and
AQP9 in ovarian tissues by reverse transcription - quantitative ( RT - q)PCR . -
pubmed
In conclusion ,
AQP8 and
AQP9 are differentially expressed in ovarian tissues of
patients with
PCOS vs. normal control subjects . -
pubmed
The expression of
AQP8 is closely associated with the occurrence and development of oocytes , whereas the expression of
AQP9 is associated with the success rate of pregnancy in
patients with
PCOS . -
pubmed
Sinomenine retards LPS - elicited
inflammation via down - regulating
CCAT1 in HaCaT cells . -
pubmed
Sinomenine pre - administration maintained cell viability , blocked apoptosis and relieved
inflammation with the decrease in
cleaved caspase-3 /- 9 and inflammatory factors . -
pubmed
LINC00342 regulates cell proliferation , apoptosis , migration and invasion in colon
adenocarcinoma via miR-545 - 5p /
MDM2 axis . -
pubmed
METHODS : The
LINC00342 expressions in
COAD tissues were detected via qRT - PCR and in situ hybridization analysis . -
pubmed
RESULTS :
LINC00342 was over - expressed in
COAD tissues and
LINC00342 overexpression was related to the poor prognosis of
COAD patients . -
pubmed
In
COAD tissues and cell lines ,
LINC00342 expression was positively correlated to
MDM2 expression , while it was negatively correlated to miR-545 - 5p expression . -
pubmed
LINC00342 knockdown suppressed COAD
tumor growth in vivo . -
pubmed
Microbiota - Derived Metabolites Suppress
Arthritis by Amplifying
Aryl - Hydrocarbon Receptor Activation in Regulatory B Cells . -
pubmed
Butyrate supplementation suppresses
arthritis in a
Breg - dependent manner by increasing the level of the
serotonin - derived metabolite
5 - Hydroxyindole-3 - acetic acid (
5 - HIAA ) , which activates the
aryl - hydrocarbon receptor (
AhR ) , a newly discovered transcriptional marker for Breg function . -
pubmed
It has been reported that
angiotensin II (
Ang - II ) damages the function of EPCs in
atherosclerotic plaque through induction of oxidative stress . -
pubmed
Our study results indicated that
Sesn2 facilitated the viability of EPCs After treatment with
Ang - II , as well as provided a potential therapeutic target to alleviate the progression of
atherosclerosis . -
pubmed
Marein ameliorates
Ang II /
hypoxia - induced abnormal glucolipid metabolism by modulating the
HIF-1alpha /
PPARalpha / gamma pathway in
H9c2 cells . -
pubmed
Treating
angiotensin II /
hypoxia - stimulated
H9c2 cells with
marein led to decreasing cell surface area , intracellular total protein ,
atrial natriuretic peptide , and free
fatty acids levels , but increasing
glucose level . -
pubmed
The effect of
nutmeg essential oil constituents on Novikoff
hepatoma cell viability and communication through
Cx43 gap junctions . -
pubmed
Disappearance of a highly unusual clone , 46,XY , del(7)(p12),t(9;22)(q34;q11 ) in
chronic myeloid leukemia after treatment with recombinant
interferon and
cytosine arabinoside . -
pubmed
Toxicity was limited to asymptomatic
SGOT elevations in 3
patients and
nausea and
vomiting in 4
patients that required cessation of therapy in 2 . -
pubmed
The purpose of the present studies was to compare the pharmacodynamic profile of the new
ACE inhibitor cilazapril with the
beta - adrenoceptor antagonist
propranolol in healthy
subjects and in
hypertensive patients . -
pubmed
Phospholipase A2 ,
leukotriene C4 and
prostaglandin E2 levels in aqueous humour of
guinea pigs with experimental S - antigen induced
autoimmune uveitis . -
pubmed
Purified
S - antigen was used to induce experimental
autoimmune uveitis in 42
guinea pigs . -
pubmed
In aqueous humour the increase in
phospholipase - A2 and proteins as well as
myeloperoxidase measured from iris - ciliary blocks correlated well with the severity of
uveitis evaluated by clinical grading . -
pubmed
Of these biochemical parameters , only
gamma glutamyl transpeptidase was significantly elevated in test
animals with experimental
autoimmune uveitis . -
pubmed
Effects of
insulin perfusion and altered
glucose concentrations on heart function in 3 - day and 6 - week
diabetic rats . -
pubmed
Diabetes is known to result in
depression of myocardial function , whereas hearts from
insulin - treated
diabetic rats exhibit functional characteristics similar to controls . -
pubmed
In the present study , we have studied the effect of
insulin perfusion on cardiac performance of 3 - day and 6 - week
streptozotocin (
STZ )
diabetic rats . -
pubmed
These results suggest that
diabetes results in a loss of myocardial sensitivity to
insulin which seems to occur as early as 3 days after induction of
diabetes with
STZ . -
pubmed
The study also demonstrates that the beneficial effects of in vivo
insulin treatment on myocardial alterations induced by
diabetes are not due to its direct myocardial effects . -
pubmed
The application of radioimmunoassay of
insulin ,
C - peptide , gastrin , glucagon ,
vasoactive intestinal polypeptides (
VIP ) , somatostatin ,
human pancreatic polypeptides (
hPP ) ,
substance P and
neurotensin to detect
endocrine tumors of the pancreas and other organ systems is undoubtedly important in the clinical management of
patients suspected of having
tumors that secrete these hormones . -
pubmed
Response to fibrinolytic activity and
factor VIII - related antigen to stimulation with
desmopressin in
hyperlipoproteinemia . -
pubmed
Factor VIII was higher than normal in most
patients with
hyperlipoproteinemia ; the level increased after stimulation with
DDAVP in every
patient . -
pubmed
In addition , the immune dysfunctions that characterize some
human diseases , such as
cancer , depend not only on the immune system per se , but also at least in part , on altered secretion of immunomodulating neurohormones , including
MLT and opioid peptides . -
pubmed
The study was performed in 90
patients with advanced
solid neoplasms , who received
IL-2 at a dose of 3 million IU / day subcutaneously for 6 days a week for 4 weeks plus
MLT at a daily dose of 40 mg . -
pubmed
The results were compared to those in 40
cancer patients treated with
IL-2 alone . -
pubmed
GLUT-2 gene transfer into
insulinoma cells confers both low and high affinity
glucose - stimulated
insulin release . -
pubmed
The
rat insulinoma cell line
RIN 1046 - 38 loses
glucose - stimulated
insulin secretion as a function of time in culture . -
pubmed
None of the
patients experienced severe
leukopenia at the time of diagnosis , but the mean lymphocyte count decreased to 495 / mm3 ( range 100 to 830 / mm3 ) and 2
patients had inverted
CD4 /
CD8 T - cell ratios . -
pubmed
Endometrial expression of mRNA encoding
epidermal growth factor receptor in
normal and leiomyomatous uteri throughout the menstrual cycle . -
pubmed
CONCLUSION : This data suggest that endometrial
EGFR mRNA expression varies in association with the histologic changes of the normal menstrual cycle , and may be associated with the presence of
leiomyomata uteri . -
pubmed
Hypertriglyceridemic effect of
fructose is mainly due to an increase in hepatic production of
VLDL . -
pubmed
Interferon and thymic hormones in the therapy of
human myocarditis and
idiopathic dilated cardiomyopathy . -
pubmed
The aim of this study was to evaluate the efficacy of
interferon - alpha (
IFN ) and
thymomodulin in the treatment of
idiopathic myocarditis and
IDC . -
pubmed
Our results suggest that treatment of
myocarditis and/or IDC with
IFN or
thymomodulin induces an earlier and significantly superior clinical improvement than conventional therapy alone . -
pubmed
Immunolocalisation of the
kinin moiety and
bradykinin ( B2 ) receptors on synovial fluid neutrophils in
rheumatoid arthritis . -
pubmed
Generation of
Alzheimer beta - amyloid protein in the trans - Golgi network in the apparent absence of vesicle formation . -
pubmed
beta - amyloid protein (
A beta ) formation was reconstituted in permeabilized neuroblastoma cells expressing
human Alzheimer beta - amyloid precursor protein (
beta APP ) harboring the Swedish double mutation associated with familial early - onset
Alzheimer disease . -
pubmed
Does
insulin resistance unite the separate components of the
insulin resistance syndrome ? -
pubmed
The observation that M loaded on both factors suggests that a resistance to
insulin action may provide the mechanism uniting the features of the
insulin resistance syndrome . -
pubmed
Transforming growth factor - beta (
TGF - beta ) has been shown to stimulate extracellular matrix formation and inhibit proteolytic matrix degradation in periodontal
wound healing . -
pubmed
Short - chain fatty acids inhibit intestinal
trefoil factor gene expression in
colon cancer cells . -
pubmed
Intestinal trefoil factor (
ITF ) gene expression was detected in five
colon cancer cell lines . -
pubmed
We conclude that
butyrate inhibits
ITF expression in
colon cancer cells and that this effect may be mediated transcriptionally and independently of its effects on differentiation . -
pubmed
Bispecific antibodies capable of simultaneously binding a
tumor surface antigen and the
T - cell receptor / CD3 complex are capable of inducing polyclonal immune effector cells to destroy targeted
tumor cells . -
pubmed
The bispecific ligand - antibody conjugate described in this study is a chemical conjugate between an anti -
CD3 monoclonal antibody (
MAb ) and
folic acid , the ligand for a high - affinity surface receptor expressed on the surface of
choroid plexus tumors . -
pubmed
SV11
mice transgenic for
SV40 large T antigen and its promoter develop solid
choroid plexus tumors in the brain . -
pubmed
Sustained high - level expression of
full - length human factor VIII and restoration of clotting activity in
hemophilic mice using a minimal adenovirus vector . -
pubmed
The successful prophylactic treatment of
hemophilia A by frequent infusions of plasma concentrates or
recombinant factor VIII (
hFVIII ) indicates that gene therapy may be a potential alternative for the treatment of the disease . -
pubmed
The functionality of the protein was confirmed by the restoration of
blood coagulation capacity in
MiniAdFVIII - treated
hemophilic mice , as determined by tail clipping observations . -
pubmed
METHODS : Maternal and fetal circulating
angiogenin concentrations were compared at birth between 16 pregnancies with
SGA ( 7 delivered vaginally and 9 delivered by elective cesarean section ) and 46 pregnancies with
AGA ( 27 delivered vaginally and 19 delivered by cesarean section ) . -
pubmed
However , maternal serum
angiogenin levels were significantly higher than those in fetal serum within both SGA and
AGA infant pregnancies . -
pubmed
CONCLUSION : These results suggest that there is no difference in
angiogenin synthesis between
SGA and
AGA pregnancies . -
pubmed
Scar , a member of the
WASp protein family , was discovered in
Dictyostelium discoideum during a genetic screen for second - site mutations that suppressed a
developmental defect . -
pubmed
Possible involvement of
endothelin-1 and
nitric oxide in the pathogenesis of proliferative
diabetic retinopathy . -
pubmed
BACKGROUND : Overproduction of
endothelin-1 (
ET-1 ) and
nitric oxide (
NO ) in the retina is demonstrated in experimental
diabetic animals . -
pubmed
To clarify the possible involvement of
ET-1 and
NO in the pathogenesis of
diabetic retinopathy , the authors examined the vitreous levels of these principal endothelium - derived vasoactive substances in
patients with
proliferative diabetic retinopathy (
PDR ) . -
pubmed
RESULTS :
Endothelin-1 levels ( mean + /- SE ) were 21.5 + /- 1.7 pg / mL in the vitreous of
patients with
PDR and 16.7 + /- 0.7 pg / mL in the vitreous of
patients with macular hole . -
pubmed
CONCLUSION : These results indicate that
ET-1 and
NO may be related in the pathogenesis of
PDR . -
pubmed
Proinsulin C - peptide has been reported to have some biological activities and to be possibly involved in the development of
diabetic microangiopathy . -
pubmed
Attenuation of hemolysate - induced
cerebrovascular endothelial cell injury and of production of
endothelin-1 and big
endothelin-1 by an
endothelin - converting enzyme inhibitor . -
pubmed
BACKGROUND :
Endothelin-1 (
ET-1 ) is a potent and long - acting vasoconstrictive peptide that has been implicated in the pathogenesis of
cerebral vasospasm after
subarachnoid hemorrhage (
SAH ) . -
pubmed
ET-1 has been shown to be present in the cerebrospinal fluid of
patients after
SAH , and substances produced during
hemolysis of subarachnoid blood clots are believed to be responsible for stimulating the production of
ET-1 . -
pubmed
Activation of the
c - Jun N terminal kinase pathway in an
animal model of
Parkinson ' s disease . -
pubmed
We studied the pattern of activation of the
c - Jun N terminal kinase (
JNK ) signal transduction pathway during the course of a subacute
MPTP mouse model of
Parkinson ' s disease . -
pubmed
[ Study of reactions for detection of the
rheumatoid factor in the course of
syphilis ] . -
pubmed
Identification and clinical relevance of
receptor activator of nuclear factor kappaB ligand expression of
myeloma cells . -
pubmed
Microgranular and t(11;17)/
PLZF - RARalpha variants of
acute promyelocytic leukemia also present the flow cytometric pattern of
CD13 ,
CD34 , and
CD15 expression characteristic of PML - RARalpha gene rearrangement . -
pubmed
Homogeneous expression of
CD33 was observed in 76 % of the classical
APL cases and in 100 % of the microgranular cases . -
pubmed
Additionally , we have studied two cases of
PLZF - RARalpha APL that also displayed the same immunophenotype described for classical
APL . -
pubmed
Thus , the immunophenotypic profile highly characteristic of the PML - RARalpha gene rearrangement was also observed in microgranular and
PLZF - RARalpha variants of
APL . -
pubmed
Polyploid formation via chromosome duplication induced by
CTP :
phosphocholine cytidylyltransferase deficiency and
Bcl-2 overexpression : identification of two novel endogenous factors . -
pubmed
Alterations in the alpha2 isoform of
Na , K - ATPase associated with
familial hemiplegic migraine type 2 . -
pubmed
A number of missense mutations in the
Na , K - ATPase alpha2 catalytic subunit have been identified in
familial hemiplegic migraine with aura . -
pubmed
Here , we investigate the proatherogenic role of NKT cells in an adoptive transfer model of
atherosclerosis , using as recipients immune - deficient ,
atherosclerosis - susceptible
RAG1(-/-)
LDLR(-/- )
mice . -
pubmed
The total serum from
hypercholesterolemic mice leads to a small but significant activation of
Valpha14Jalpha18 T - cell receptor - expressing hybridoma line by dendritic cells that is
CD1d - dependent . -
pubmed
The patient carrying the last duplication presents sex reversal ,
Peters ' anomaly and
renal cysts and the duplication is located 4Mb away from the
HSD17B1 gene , coding a key enzyme of
testosterone biosynthesis . -
pubmed
Apixaban is an oral , direct
Factor Xa inhibitor that is being developed by Bristol - Myers Squibb Co and Pfizer Inc.
Apixaban is currently undergoing phase III clinical trials for
cerebrovascular ischemia ,
deep vein thrombosis and
lung embolism , and phase II clinical trials for
coronary artery disease . -
pubmed
Mutation in the
HPGD gene encoding
NAD + dependent 15 - hydroxyprostaglandin dehydrogenase underlies isolated
congenital nail clubbing (
ICNC ) . -
pubmed
CONCLUSIONS : The involvement of
15 - PGDH in the pathogenesis of
ICNC may open up interesting perspectives into the function of this enzyme in nail morphogenesis / development . -
pubmed
Some soluble markers , including soluble
mesothelin and
osteopontin , have been previously proposed for
MPM diagnosis but none has been validated yet . -
pubmed
Soluble
mesothelin , assessed in blood and in
pleural effusion , seems to be the most promising candidate . -
pubmed
Despite sometimes a good sensitivity , other potential markers as
osteopontin are of little interest for
MPM diagnosis because of a low specificity . -
pubmed
In conclusion , the present data do not justify the use of biology for
MPM diagnosis in routine yet but rather suggest a need for a continuing evaluation of soluble
mesothelin in clinical studies and the search for other potential
tumor markers . -
pubmed
[ Cerebral proteolysis of amiloid - b peptide : relevance of
insulin - degrading enzyme in
Alzheimer ' s disease ] . -
pubmed
One of the distinctive features of
AD is the excessive accumulation of
amyloid - b ( Ab ) peptide in the brain . -
pubmed
IDE expression and activity are significantly decreased in
AD brains compared to age - matched controls . -
pubmed
An autosomal recessive form of
hereditary spastic paraplegia (
AR - HSP ) is primarily caused by mutations in the
SPG7 gene , which codes for
paraplegin , a subunit of the hetero - oligomeric m - AAA protease in mitochondria . -
pubmed
In the current study , sequencing of the
SPG7 gene in the genomic DNA of 25 unrelated
HSP individuals / families led to the identification of two
HSP patients with compound heterozygous mutations ( p. G349S / p. W583C and p. A510V / p. N739KfsX741 ) in the coding sequence of the
SPG7 gene . -
pubmed
We used a
yeast complementation assay to evaluate the functional consequence of novel
SPG7 sequence variants detected in the
HSP patients . -
pubmed
By acting as a scaffolding protein ,
Cav-1 plays crucial roles in the regulation of various physiologic and patho - physiologic processes including oncogenic transformation and tumorigenesis , and
tumor invasion and metastasis . -
pubmed
Genetic background affects susceptibility to
ileocolitis in
mice deficient in two intracellular
glutathione peroxidases ,
GPx1 and
GPx2 . -
pubmed
The C57BL/6 ( B6 )
GPx1/2 double - knockout ( DKO )
mice have mild
ileocolitis , and 129S1 / Sv ( 129 ) DKO
mice have severe
inflammation . -
pubmed
We used diet to modulate
ileocolitis ; a
casein - based defined diet with AIN76A micronutrients ( AIN ) attenuates
inflammation compared to conventional LabDiets . -
pubmed
Replacement therapy with
factor VIII (
FVIII ) concentrates has become the mainstay of treatment for
hemophilia , but about 30 % of patients with a severe disease develop neutralizing antibodies against
FVIII , which can lead to treatment resistance and an increased risk of
bleeding . -
pubmed
High - dose
FVIII ITI appears to induce immune tolerance more rapidly than low - dose protocols and with a reduced risk of
bleeding episodes . -
pubmed
A large set of
estrogen receptor beta - interacting proteins identified by tandem affinity purification in hormone - responsive
human breast cancer cell nuclei . -
pubmed
Estrogen receptors alpha (
ER - alpha ) and beta (
ER - beta ) play distinct biological roles in onset and progression of hormone - responsive
breast cancer , with
ER - beta exerting a modulatory activity on
ER - alpha - mediated
estrogen signaling and stimulation of cell proliferation by mechanisms still not fully understood . -
pubmed
Functional annotation by bioinformatics analyses of the 303 proteins that co - purify with
ER - beta from nuclear extracts identify several new molecular partners of this receptor subtype that represents nodal points of a large protein network controlling multiple processes and functions in
breast cancer cells . -
pubmed
This probably occurs by correcting
diabetes - linked increased clearance of
thiamine , maintaining activity and expression of
thiamine pyrophosphate - dependent enzymes that help counter the adverse effects of high
glucose concentrations - particularly
transketolase . -
pubmed
Thiamine supplementation prevented the development of early - stage
nephropathy in
diabetic rats and reversed increased urinary
albumin excretion in
patients with
type 2 diabetes and
microalbuminuria in two recent clinical trials . -
pubmed
Visfatin is known to play a role in
obesity - related
metabolic diseases and inflammatory conditions . -
pubmed
Here , the role of
visfatin in FFA - induced
inflammation was investigated in hepatocytes . -
pubmed
The expression of
visfatin is closely associated with the expression of
proinflammatory cytokines in FFA - induced
inflammation and is significantly decreased by
NF - kappaB inhibition in
HepG2 cells . -
pubmed
Visfatin may play a role in FFA - induced
inflammation in hepatocytes through the
NF - kappaB pathway . -
pubmed
IL-22 , but not
IL-17 , dominant environment in
cutaneous T - cell lymphoma . -
pubmed
Recently ,
interleukin ( IL )- 22 - producing T cells were reported in skin of
patients with
AD . -
pubmed
In this study , we investigated expression levels of
T ( H ) 22 - and T ( H ) 17 - related molecules in lesional skin and sera isolated from
patients with
CTCL . -
pubmed
Phosphorylation of
STAT3 was also assessed in lesional skin of
CTCL and
psoriasis by immunohistochemistry . -
pubmed
RESULTS :
IL-22 ,
IL-10 ,
IL-4 ,
CCL20 , and
CCR6 mRNA and protein levels , but not
IL-17A ,
IL-17F ,
IL-23p19 ,
IL-8 , or
IL-20 , were significantly elevated in lesional skin of
CTCL . -
pubmed
Phosphorylation of
STAT3 was detected in epidermis of
CTCL skin . -
pubmed
Moreover , serum
IL-22 ,
IL-10 , and
CCL20 levels were increased in
CTCL and correlated with disease severity . -
pubmed
CONCLUSIONS : Our results suggest that
IL-22 is important in establishing the
tumor microenvironment for
CTCL . -
pubmed
Enhanced expression of
CCL20 may explain
epidermal hyperplasia and migration of
CCR6(+ ) cells , such as Langerhans cells , into lesional skin . -
pubmed
Relatively low expression of
IL-17 may explain the lack of neutrophils in lesions of
CTCL , which correlates with
bacterial infections that commonly occur in skin affected by
CTCL . -
pubmed
[ Effect of acupuncture on contents of
beta - endorphin in the plasma and hypothalamus in
rats with stress - induced
gastric mucosal injury ] . -
pubmed
Compared with the corresponding model groups , the gastrointestinal propulsion rate was increased remarkably in the prevention group ( P & lt ; 0.05 ) , and the
gastric mucosal ulcer indexes and the contents of plasma
beta - EP level were decreased obviously in both treatment and prevention groups ( P & lt ; 0.05 , P & lt ; 0.01 ) . -
pubmed
CONCLUSION : Acupuncture of ST 36 , CV 12 and PC 6 can promote the repair of
gastric mucosal injury and improve gastrointestinal function , which may be related to its effects in reducing plasma
beta - EP and upregulating hypothalamic
beta - EP level . -
pubmed
Monoamine oxidase - B (
MAO - B ) inhibitor has been used as neuroprotectants to treat the motor deficits of
Parkinson ' s disease (
PD ) . -
pubmed
IgG4 - Related
Perineural Disease . -
pubmed
Retrospective review of 106
patients with
IgG4 - related disease identified 21
peripheral nerve lesions in 7
patients . -
pubmed
IgG4 - related disease of the peripheral nervous system is characterized by orbital or paravertebral localization , perineural mass formation , and rare
neurologic symptoms . -
pubmed
The term "
IgG4 - related
perineural disease " seems appropriate to describe this entity . -
pubmed
Treatment of CD4 + T cells with Virus - Like Particles ( VLP ) containing
Vpx results in the loss of
SAMHD1 expression that correlates with an increased permissiveness to
HIV-1 infection and accumulation of reverse transcribed viral DNA without promoting transcription from the viral LTR . -
pubmed
Importantly ,
CD4 + T - cells from patients with
Aicardi - Goutieres Syndrome harboring mutation in the
SAMHD1 gene display an increased susceptibility to
HIV-1 infection that is not further enhanced by VLP - Vpx - treatment . -
pubmed
These results highlight the crucial role of
SAMHD1 in mediating restriction of
HIV-1 infection in quiescent CD4 + T - cells and could impact our understanding of
HIV-1 mediated
CD4 + T - cell depletion and establishment of the viral reservoir , two of the
HIV /
AIDS hallmarks . -
pubmed
METHODS : To evaluate the estrogenic effect of SG , we first examined
estrogen receptor (
ER ) activation by SG treatment in
breast adenocarcinoma cells and confirmed the estrogenic effect of SG in vivo ovariectomized
rats . -
pubmed
RESULTS : SG significantly increased
ERalpha phosphorylation , and its downstream effectors ,
extracellular signal - regulated kinase (
ERK ) and
protein kinase B (
Akt ) phosphorylation in
breast adenocarcinoma cells . -
pubmed
CONCLUSION : Taken together , these data indicate that SG has phytoestrogen - like properties through
ERK and
Akt activation , implying that it could be protective and beneficial for the management of
menopausal symptoms . -
pubmed
Significance of
osteopontin in the sensitivity of
malignant pleural mesothelioma to
pemetrexed . -
pubmed
High immunohistochemical expression of
SPP1 /
OPN was observed in two of three
MPM patients who had a partial response to
PEM - based chemotherapy . -
pubmed
PEM has antitumor effects in
MPM cells dependent on
SPP1 /
OPN overexpression resulting in
AKT activation . -
pubmed
Our results suggest that
SPP1 may be used as a single predictive biomarker of the effectiveness of
PEM treatment in
MPM . -
pubmed
Preventive effects of siRNA targeting
PPARgamma gene on
steroid - induced
osteonecrosis in
rabbits . -
pubmed
UNLABELLED : PURPOSES / AIM : Glucocorticoid
steroids can induce expression of
PPARgamma gene and enhance adipogenesis by bone marrow mesenchymal stem cells ( BMSCs ) , which may result in
osteonecrosis of the femoral head . -
pubmed
We hypothesized that siRNA targeting
PPARgamma gene may prevent
steroid - induced adipogenesis and
osteonecrosis in
rabbit . -
pubmed
The purpose of this study was to evaluate the preventive effects of siRNA targeting
PPARgamma gene on
steroid - induced adipogenesis and
osteonecrosis . -
pubmed
CONCLUSION : siRNA targeting
PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent
steroid - induced
osteonecrosis in
rabbit . -
pubmed
The
sptC gene encodes a precursor composed of a signal peptide , an N - terminal propeptide consisting of a core domain ( N * ) and a linker peptide , a subtilisin - like catalytic domain , a
polycystic kidney disease domain (
PkdD ) , and a chitin - binding domain ( ChBD ) . -
pubmed
Platelets ,
cyclooxygenases , and
colon cancer . -
pubmed
Activated platelets , in response to
tissue damage , induce a proinflammatory program involving the aberrant expression of
cyclooxygenase ( COX )- 2 , which leads to increased tissue concentrations of the proinflammatory and protumorigenic
prostaglandin E2 . -
pubmed
In the current study we evaluated the added value of a combined protocol of blood
oxygen level dependent ( BOLD ) imaging during
hyperoxic challenge ( termed hemodynamic response imaging ( HRI ) ) in an orthotopic
mouse model for
glioblastoma under anti - angiogenic treatment with B20 - 4.1.1 , an anti -
VEGF antibody . -
pubmed
In
glioblastoma tumors , the elevated
HRI indicated progressive angiogenesis as further confirmed by histology . -
pubmed
Genetics :
BCL11A - targeting triple - negative
breast cancer ? -
pubmed
Furthermore , PFO+ subjects had an increased incidence of
acute mountain sickness (
AMS ) at
ALT1 concomitant with significantly lower peripheral
O2 saturation ( SpO2 ) . -
pubmed
Dab2IP (
DOC-2 /
DAB2 interacting protein ) is a GTPase - activating protein which is involved in various aspects of brain development in addition to its roles in
tumor formation and apoptosis in other systems . -
pubmed
Biochemical and Functional Comparisons of
mdx and
Sgcg(-/- )
Muscular Dystrophy Mouse Models . -
pubmed
The
mdx mouse , which is
dystrophin - deficient , has long been used to model this disease . -
pubmed
Histologically the
Sgcg(-/- )
mice displayed increased
fibrosis and variable fiber size . -
pubmed
By quantitative Evan 's blue
dye uptake and
hydroxyproline content two key disease determinants , membrane permeability and
fibrosis respectively , were also proven worse in the
Sgcg(-/- )
mice . -
pubmed
Abeta ( 1 - 40 ) peptide supramolecular assembly and fibril formation processes are widely recognized to have direct implications in the progression of
Alzheimer ' s disease . -
pubmed
Desflurane preconditioning protects human umbilical vein endothelial cells against
anoxia / reoxygenation by upregulating
NLRP12 and inhibiting non - canonical
nuclear factor - kappaB signaling . -
pubmed
Desflurane preconditioning enhanced HUVEC survival and protected the cells against
A / R injury , and our results suggested that this process involved the upregulation of
NLRP12 and the inhibition of non - canonical
NF - kappaB signaling . -
pubmed
BACKGROUND :
Tissue factor (
TF ) is involved in
tumor growth and metastasis and contributes to
venous thromboembolism (
VTE ) in
cancer , including
gynecological malignancies . -
pubmed
RESULTS : D - Dimer , MV TF PCA , and
sCD62P , but not the
tumor marker ,
CA-125 , significantly differentiated
patients with malignant ( n=40 ) from those with benign
tumors ( n=15 ) and healthy controls ( n=34 ) . -
pubmed
In
cancer patients , only D - Dimer and
CA-125 correlated with the FIGO stage . -
pubmed
CONCLUSIONS :
MV TF PCA , but not
plasma TF antigen , may provide valuable additional information for the diagnostic work - up of
women with suspected
ovarian cancer . -
pubmed
TAMOF is a devastating
microangiopathy that can occur in association with the new onset of
T1DM , and should be considered with the onset of
thrombocytopenia ,
renal failure , and raised
LDH . -
pubmed
Studies of
CD40L - deficient patients reveal the critical role of
CD40L -
CD40 interaction for the function of T , B , and dendritic cells . -
pubmed
METHODS : After observing the improvement of refractory disseminated
mycobacterial infection in a
CD40L - deficient patient by recombinant
human IFN - gamma (
rhIFN - gamma ) adjuvant therapy , we investigated macrophage functions from
CD40L - deficient patients . -
pubmed
RESULTS : Macrophages from
CD40L - deficient patients exhibited defective fungicidal activity and reduced oxidative burst , both of which improved in the presence of
rhIFN - gamma but not
sCD40L. -
pubmed
In addition , the improvement of macrophage immune responses by
IFN - gamma suggests this
cytokine as a potential therapeutic option for
patients with
CD40L deficiency . -
pubmed
The risk for
PD in these groups does not linearly increase with
glucosylceramide ( GC ) accumulation or with acid
beta - glucocerebrosidase (
GCase ) activity . -
pubmed
Incidence of human
cytomegalovirus infection and T - cell response in
patients with
psoriasis before and during
antitumour necrosis factor - alpha therapy . -
pubmed
Green mamba peptide targets
type-2 vasopressin receptor against
polycystic kidney disease . -
pubmed
CD1 - pcy / pcy
mice , a juvenile model of
PKD , daily treated with 13 [ Formula : see text]g of
mambaquaretin-1 for 99 d , developed less abundant ( by 33 % ) and smaller ( by 47 % )
cysts than control
mice . -
pubmed
Significant reductions in the phosphorylation of signaling molecules
focal adhesion kinase ,
extracellular signal - regulated kinases 1 and 2 , and v -
Akt murine thymoma viral oncogene were observed in male
MIPbeta1KO islets when compared to controls . -
pubmed
Female
MIPbeta1KO mice did not develop
glucose intolerance or reduced beta - cell mass until 16 weeks post -
tamoxifen . -
pubmed
Glucose intolerance remained in both genders of aged
MIPbeta1KO mice . -
pubmed
Decreased
NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary
Streptococcus pneumoniae infection . -
pubmed
Examination of
NLRP3 inflammasome expression illustrated decreased
NLRP3 mRNA expression and decreased
IL1beta production in aged lung in response to
secondary S. pneumoniae infection . -
pubmed
Long noncoding RNA LINC01510 promotes the growth of
colorectal cancer cells by modulating
MET expression . -
pubmed
Long intergenic non - protein coding RNA 1510 , an enhancer lncRNA ( LINC01510 ) , a lncRNA enhancer is upregulated in
colorectal cancer (
CRC ) , and its expression might relate to
MET as revealed by lncRNA microarray data . -
pubmed
Results : In the present study , we found that
LINC01510 was significantly upregulated in
CRC tissues and cell lines . -
pubmed
Meanwhile , gain- and loss - of - function assays demonstrated that
LINC01510 overexpression increased
CRC cell proliferation , and promoted cell cycle progression from the G1 phase to the S phase . -
pubmed
Conclusions : Taken together , our findings suggested that upregulation of
LINC01510 contributes to the proliferation of
CRC cells , at least in part , through the regulation of
MET protein . -
pubmed
Increased
follicular atresia was evident in
NeurARKO ovaries with a 4 - fold increase in unhealthy large preantral follicles ( p & lt ; 0.01 ) . -
pubmed
[ Effects of
peroxisome proliferator - activated receptor gamma -
toll - like receptor 4 -
tumor necrosis factor - alpha targeted pathway on
hyperglycemia induced
myocardium inflammation and oxidative stress ] . -
pubmed
OBJECTIVE : To investigate the potential effects and mechanism on
peroxisome proliferator - activated receptor gamma -
toll - like receptor 4 -
tumor necrosis factor - alpha (
PPARgamma -
TLR4 -
TNF - alpha ) targeted pathway on
hyperglycemia induced
myocardium inflammation and oxidative stress . -
pubmed
CONCLUSIONS : 4 mgxkg-1xd-1
pioglitazone could activate
PPARgamma -
TLR4 -
TNF - alpha targeted pathway , thus inhibit inflammatory and oxidative stress factors expression , and down - regulate
hyperglycemia induced myocardium inflammatory and oxidative stress level , but the effect did not show a dose dependent manner . -
pubmed
Oxidative stress and
NF - kappaB signaling are involved in LPS induced
pulmonary dysplasia in chick embryos . -
pubmed
LPS treatment also resulted in reduced
CAV-1 expression and up - regulation of
Collagen I , suggesting increased
lung fibrosis , which was verified by Masson staining . -
pubmed
Background :
Bevacizumab is a recombinant humanised monoclonal antibody to
vascular endothelial growth factor shown to improve survival in advanced
solid cancers . -
pubmed
Forty four percent of 682
melanomas assessed had a
BRAFV600 mutation . -
pubmed
[
PD - L1 - Mediated Immune Escape Mechanism of
Cancer Stem - Like Cells ] . -
pubmed
In this review article , we summarize the expression of
PD - L1 , a molecular target of ICIs , in
CSCs , and discuss the possibility of CSC - targeting immunotherapy using ICIs . -
pubmed
Here , we investigated kidney function of a novel gene associated with
nephronophthisis ,
CEP164 , coding a centriolar distal appendage protein , using a
Cep164 knockout
mouse model . -
pubmed
Immunotherapy with T cells expressing
chimeric antigen receptors (
CAR ) is an emerging and promising treatment against
refractory cancers . -
pubmed
Factors Associated with the Need for
Insulin as a Complementary Treatment to
Metformin in
Gestational Diabetes Mellitus . -
pubmed
OBJECTIVE : To evaluate the factors associated with the need for
insulin as a complementary treatment to
metformin in pregnant
women with
gestational diabetes mellitus (
GDM ) . -
pubmed
CONCLUSION :
Obesity resulted in an increased chance of the mother needing
insulin as a complementary treatment to
metformin , while FG & lt ; 90 mg / dL and primiparity were protective factors . -
pubmed
Early outcomes with utilization of
tissue plasminogen activator in COVID-19 - associated
respiratory distress : A series of five cases . -
pubmed
The anti - proliferative activity of
ursolic acid in
MDA - MB-231 human breast cancer cells through
Nrf2 pathway regulation . -
pubmed
The potential mechanisms of action of
ursolic acid ( UA ) in regulating cell proliferation in
MDA - MB-231 human breast cancer cells through
Nrf2 pathway were investigated . -
pubmed
There were 15 subjects with
MAPT H1 / H1 and 11 subjects with
MAPT H1 / H2 within
PD - MCI , and 33 subjects with
MAPT H1 / H1 and 19 subjects with
MAPT H1 / H2 within all
PD . -
pubmed
Further , the subgroup of
PD patients carrying the risky
MAPT H1 / H1 haplotype was compared with noncarriers (
MAPT H1 / H2 haplotype ) in terms of CBF by a two - sample t test . -
pubmed
Additionally , the
PD patients with
MAPT H1 / H1 haplotype had decreased perfusion than the ones with H1 / H2 haplotype at the posterior areas of the visual network ( VN ) , default mode network ( DMN ) , and dorsal attention network ( DAN ) . -
pubmed
Targeting
IL-1beta in the Treatment of
Atherosclerosis . -
pubmed
Compared with other
cytokines ,
interleukin-1beta (
IL-1beta ) is associated with acute and chronic
inflammation . -
pubmed
The results of CANTOS suggested an important role of
IL-1beta in
atherosclerosis . -
pubmed
We herein discussed the important immunomodulatory effect
IL-1beta exerts on
atherosclerosis and the potential mechanisms underlying it . -
pubmed
We also reviewed bench - to - bedside clinical translation of
IL-1beta neutralizing strategies associated with the use of
IL-1beta blockade in
patients with
atherosclerosis . -
pubmed
This significantly contributed to the pathogenesis in
AAA , whereas overactive
Transforming growth factor - beta played a major role in the pathogenesis of
TAA . -
pubmed
The allelic frequencies at 6 isozyme loci ( Es-1 , Es-2 , Es-3 , Es-4 , Es - Si and
Amy-1 ) were examined in 4 outbred Wistar strains and additionally 2
SD strains as controls . -
pubmed
The possible roles for
phospholipases in lamellar body development and in the
respiratory distress syndrome of the newborn are discussed . -
pubmed
Plasma
elastase levels were estimated in 190
patients of both sexes above the age of 65 with the exception of one male subject with
prostatic carcinoma who was 51 years of age . -
pubmed
Human rotavirus strain Ro1845 , which was isolated in 1985 from an Israeli child with
diarrhea , has a
hemagglutinin that is capable of agglutinating erythrocytes from
guinea pigs ,
sheep ,
chickens , and
humans ( group O ) . -
pubmed
Patients with a diagnostic biopsy , as compared to patients with a nondiagnostic biopsy , had a statistically significant increase in the frequency of having
AIDS diagnosed before the biopsy , longer duration of
AIDS ( in patients with
AIDS diagnosed before the biopsy ) , greater number of different prior
opportunistic infections , and a more elevated
serum alkaline phosphatase level . -
pubmed
In particular , the 15 patients with
hepatic mycobacterial infection , as compared to the other patients , had a statistically significant increase in the frequency of having
AIDS diagnosed prior to the biopsy , longer duration of
AIDS , more frequent prior
opportunistic infections , more severe
leukopenia , and a more elevated
serum alkaline phosphatase level . -
pubmed
[ A study on
serum creatine phosphokinase and type A behavior in
schizophrenia ] . -
pubmed
The
CPK levels of 79
patients with
schizophrenia ( 36
males and 43 females and 88 normal control subjects ( 53
males and 35 females ) were assessed . -
pubmed
The result shows that the
CPK level of the
patients with
acute schizophrenia ( 307.33 Iu / L ) was significantly higher than that of the normal control subjects ( 160.51 Iu / L ) ( t = 3.534 , N21 , 88 , P less than 0.01 ) and the
CPK level of male schizophrerines rose more significantly . -
pubmed
Association between
DR antigens and the occurrence of
cytotoxic alloantibodies was studied in 251
patients on dialysis . -
pubmed
Leucocyte superoxide dismutase levels in acute and
chronic leukemias . -
pubmed
Superoxide dismutase "
SOD " enzyme levels in leucocytes of
patients with acute and
chronic leukemia , were measured by using Misra and Fridovich 's
epinephrine method . -
pubmed
In all types of
leukemia , the
SOD levels were found to be significantly higher than normals . -
pubmed
No relationship was found between the
SOD level and types of
leukemia . -
pubmed
Nine of ten
SLE patients exhibited significant impairment of
IgG suppression but no correlation was found between the outcome of the
IgG suppressor cell assay and disease activity or the treatment protocol applied . -
pubmed
By means of ultrasonography , arterial wall stiffness , arterial wall thickness , and the elastic modulus of the common femoral artery were estimated in a group of 19 young
insulin - dependent
diabetics . -
pubmed
We suggest that
urokinase , presumably released by the activated proliferating histiocytes , may play a major role in the extracellular matrix degradation leading to erosion of cartilage and adjacent bone in
multicentric reticulohistiocytosis . -
pubmed
Nippostrongylus brasiliensis - induced
depression of heterologous immune responses : effects of the
histamine H2 receptor antagonist ,
cimetidine . -
pubmed
Intravascular coagulation and plasma
fibrinogen in pregnancy . -
pubmed
Rehydration as a diagnostic and therapeutic measure in
hypercalcemia including an assessment of the
calcium - lowering effect of
porcine calcitonin . -
pubmed
[
Cryoglobulinemia with
gamma 1A ,
gamma 1 M multiple
paraproteinemia ] . -
pubmed
We conclude that
bromocriptine , given to
patients with
polycystic ovarian disease , inhibits
LH hypersecretion , leading to restoration of cyclic ovarian function and reduced
androgen synthesis . -
pubmed
In vitro stimulated peripheral blood lymphocytes from
multiple sclerosis patients produce idiotypes of
oligoclonal CSF IgG. -
pubmed
Anti - idiotypic ( anti - Id ) antisera prepared against
IgG from the cerebrospinal fluid of
patients with
multiple sclerosis were used to analyze culture supernatants of in vitro stimulated peripheral blood lymphocytes ( PBL ) from the
patients . -
pubmed
This finding provides additional evidence that the production of oligoclonal
IgG in
multiple sclerosis is not exclusively a feature of the central nervous system , but is also a systemic immunologic phenomenon . -
pubmed
It is concluded that female
rats are less susceptible to
CCl4 - -
alcohol - induced
liver damage , especially
hydroxyproline accumulation , which is explained by the known fact that females are more resistant against
CCL4 -
hepatotoxicity as a consequence of a minor role of bioactivation in the metabolic degradation of
CCL4 by females . -
pubmed
After injection of the antibodies in
rats , diffuse granular deposits of
rabbit IgG , typical of passive Heymann
nephritis , were detected along the glomerular capillary walls . -
pubmed
These antigens are major
glycoproteins of the BB membranes and appear to be associated with the nephritogenic antigens of passive
Heymann nephritis . -
pubmed
Integrated regulation of
very low density lipoprotein triglyceride and
apolipoprotein - B kinetics in
non - insulin - dependent diabetes mellitus . -
pubmed
Turnover rates of plasma
very low density lipoprotein (
VLDL )
triglyceride ( TG ) and
apolipoprotein - B (
apo - B ) were significantly increased in age- and weight - matched groups of normolipemic and hyperlipemic mild
diabetics , and hyperlipemic moderately severe diabetics when compared with normolipemic controls . -
pubmed
As in the normolipemic subjects , a significant correlation between
VLDL TG and
apo - B turnover rates was found in all
diabetic groups , suggesting that integration of TG and
apo - B production at synthetic and/or secretory sites is retained in
diabetes , thus resulting in increased secretion of
VLDL particles of normal composition . -
pubmed
In normolipemic mild
diabetic subjects , the fractional turnover rates of
VLDL TG and
apo - B were also significantly increased so that increased removal accompanied increased
VLDL production . -
pubmed
In the
hyperlipemic diabetics , however , the fractional turnover rates were significantly reduced , hence the increased in
VLDL removal was not sufficient to compensate for enhanced production . -
pubmed
In normolipemic mild
diabetic patients ,
low density lipoprotein (
LDL ) formation was increased , only a small fraction of
VLDL apo - B being removed via a non - LDL pathway , presumably as remnant
VLDL . -
pubmed
In hyperlipemic mild
diabetics , removal of
VLDL apo - B via both the
LDL and non - LDL pathways was increased . -
pubmed
In hyperlipemic moderately severe
diabetes ,
LDL formation was not increased ; catabolism of
VLDL apo - B through the non - LDL route was however , fivefold greater than normal . -
pubmed
We conclude that increased
VLDL secretion is a fundamental defect in
non - insulin - dependent diabetes . -
pubmed
The increase in
LDL and/or
VLDL remnant formation , regardless of prevailing plasma lipid levels or the severity of
diabetes , provides a source of
cholesterol which may account for the atherogeneity of this disorder . -
pubmed
STUDY OBJECTIVES : To measure
interleukin-1 beta (
IL-1 beta ) levels in
pleural effusions of different etiologies and their relationship with several pleural inflammatory parameters , and to verify whether
IL-1 beta can be used as diagnostic marker in the differential diagnosis of
pleural diseases . -
pubmed
RESULTS :
IL-1 beta was above 200 pg / mL in all the
patients with
empyema but only in three
patients with other etiologies . -
pubmed
As a diagnostic criterion for
empyema , pleural
IL-1 beta concentration greater than 200 pg / mL had a sensitivity of 100 % , a specificity of 96 % , and a positive and negative predictive value of 0.82 and 1 , respectively . -
pubmed
CONCLUSIONS : Our data suggest that
IL-1 beta has a significant role in
pyogenic infections of the pleural space but not in effusions of other etiologies . -
pubmed
Increased
hypoxia has been found after
beta 2 adrenoceptor agonists ( but not
adrenaline ) in
asthmatics . -
pubmed
An
RNA polymerase I core promoter binding factor (
CPBF ) was purified to apparent homogeneity from
rat adenocarcinoma ascites cells by chromatographic fractionation on a series of columns including an oligodeoxynucleotide affinity column . -
pubmed
Interferons (
IFNs ) are families of
cytokines which have been discovered and extensively characterized in the context of host defense against
viral infections . -
pubmed
We describe a PCR - based assay for determining
c - erbB-2 oncogene amplification in
breast cancer in which we use the TaqMan system . -
pubmed
This homogeneous assay is time - saving , avoids usually cumbersome postamplification procedures ( that can be additional sources of inaccuracy and contamination ) , and seems suitable for determination of
c - erbB-2 oncogene amplification in
tumor specimens . -
pubmed
Treatment of
chronic hepatitis C with
interferon - alpha . -
pubmed
OBJECTIVE : to identify pretreatment predictive factors of long - term biochemical and virological response to
interferon - alpha in
chronic hepatitis C and to determine the effects of a second course of
interferon - alpha in
patients who responded but relapsed after
interferon withdrawal . -
pubmed
PATIENTS : 112
patients with
chronic hepatitis C were treated with recombinant
interferon - alpha ( 3 MU three times a week for 6 months ) . -
pubmed
We found : ( a ) a point mutation and loss of the specific activity of the
tumor suppressor gene
p53 without alteration of the apoptotic response to
transforming growth factor beta1 ; ( b ) a gradual decrease of
retinoblastoma protein , which was constantly present , mainly in a hyperphosphorylated form ; and ( c ) an increase of cyclin - dependent kinase inhibitor
p27 expression in confluent differentiating cells , as expected , whereas , surprisingly , a disappearance of the
p21 protein was observed in parallel . -
pubmed
Detection of circulating
cancer cells by nested reverse transcription - polymerase chain reaction of
cytokeratin-19 (
K19)--possible clinical significance in advanced
gastric cancer . -
pubmed
Intermediate filament cytokeratin-19 (
K19 ) protein is expressed in
normal and malignant gastrointestinal epithelial cells , but not in peripheral blood ( PB ) . -
pubmed
Small amount of circulating
gastric cancer cells can be detected by a sensitive nested reverse transcription - polymerase chain reaction ( RTPCR ) with primers specific for
K19 mRNA . -
pubmed
None of the other pertinent clinicopathological features , including the disease extent and the histopathologic types of the
tumors , were related to the expression of
K19 in
PB . -
pubmed
However , the survival impact of
K19 was less significant in the other 17
patients whose
tumors had responded to systemic chemotherapy . -
pubmed
We concluded that detecting circulating
cancer cells by
K19 nested RT - PCR is associated with poor prognosis of
gastric cancer , particularly in those
patients who are not responsive to systemic chemotherapy . -
pubmed
Evidence that an
HLA - DQA1 - DQB1 haplotype influences susceptibility to childhood common
acute lymphoblastic leukaemia in boys provides further support for an
infection - related aetiology . -
pubmed
Comparison of
DQA1 and
DQB1 alleles in 60 children with common
acute lymphoblastic leukaemia (
c - ALL ) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of
DQA1 * 0101/*0104 and
DQB1 * 0501 than appropriate control subjects . -
pubmed
Levodopa induces a cytoplasmic localization of
D1 dopamine receptors in striatal neurons in
Parkinson ' s disease . -
pubmed
Mutations in the
CNGB3 gene encoding the beta - subunit of the cone photoreceptor
cGMP - gated channel are responsible for
achromatopsia (
ACHM3 ) linked to chromosome 8q21 . -
pubmed
While mutations in the
CNGA3 gene on chromosome 2q11 are responsible for
achromatopsia in a subset of patients , previous linkage studies have localized another
achromatopsia locus ,
ACHM3 , on chromosome 8q21 . -
pubmed
Using
achromatopsia families in which
CNGA3 mutations have been excluded , we refined the
ACHM3 locus to a 3.7 cM region enclosed by markers D8S1838 and D8S273 . -
pubmed
In this study , we performed immunostaining for
CK ,
EMA ,
HBME ,
CD57 and
CD15 in
PTC , and benign
thyroid nodular lesions to compare the sensitivity and the specificity of these antisera for
PTC . -
pubmed
Fifty - five
PTC ( composed of 30 papillary variants and 25 follicular variants ) , 5
follicular carcinomas , 30 follicular
adenomas , and 20
thyroid nodular lesions ( 5 papillary variants and 15 follicular variants ) were submitted for immunostaining with
CK ,
EMA ,
HBME ,
CD57 , and
CD15 . -
pubmed
CK and HBME showed the highest sensitivity and specificity for
PTC when an arbitrary cutoff of more than 10 % positive cells was considered as positive diagnostic immunostaining for these sera . -
pubmed
One case of
PTC showed negative HBME but positive
CD15 , whereas three papillary variants and two follicular variants of benign thyroid nodules revealed a positive diagnostic
HBME immunostaining for
PTC and negative
CK immunostaining . -
pubmed
Any combination of positive diagnostic immunostaining with
CK+ HBME ,
CK+
CD57 or
CK+
CD15 has a sensitivity of 95 % and specificity of 90 % for
PTC . -
pubmed
Three of five follicular
carcinomas showed negative reactivity for
HBME ,
CD57 , and
CD15 . -
pubmed
A combination of immunostaining with
CK ,
HBME and
CD57 ( or
CD15 ) is a sensitive and specific test for
PTC . -
pubmed
Effects of
growth hormone treatment on red cell plasma membrane
fatty acid constituents in
hypopituitary adults . -
pubmed
The effects of replacement with
recombinant human GH (
hGH ) on red cell plasma membrane
fatty acid and
cholesterol constituents were assessed in nine adult
patients with
growth hormone deficiency . -
pubmed
NF - kappa B does not modulate sensitivity of
renal carcinoma cells to
TNF alpha - related apoptosis - inducing ligand (
TRAIL ) . -
pubmed
BACKGROUND : Immune cells express
TNF - related apoptosis - inducing ligand (
TRAIL ) and may play an important role in controlling the growth of
renal cancer . -
pubmed
RESULTS : Two
RCC lines were highly sensitive to
TRAIL - induced cell death , two were of intermediate sensitivity , and two were insensitive . -
pubmed
CONCLUSIONS :
NF - kappa B , although stimulated in these cell lines , does not play a role in the sensitivity of
RCC to
TRAIL and could play other functions in
TRAIL signaling . -
pubmed
Genomic characterization of
human SEC14L1 splice variants within a 17q25 candidate
tumor suppressor gene region and identification of an unrelated embedded expressed sequence tag . -
pubmed
We more precisely mapped
SEC14L1 within a discrete region of 17q25 that likely harbors at least one putative
breast and ovarian tumor suppressor gene . -
pubmed
As
retinoids have been shown to inhibit the growth of
breast cancer cells , loss of the proposed
SEC14L1 retinal - binding function may contribute to breast tumorigenesis . -
pubmed
As
TTPA and
CRALBP have been implicated in
retinitis pigmentosa (
RP ) , altered
SEC14L1 expression may contribute to
RP in previously unlinked families . -
pubmed
Recessively inherited mutations in the
HFE gene are responsible for
iron accumulation in most cases of
hereditary haemochromatosis and may have a role in
HCV infection . -
pubmed
AIMS : To assess the prevalence of
HFE mutations in Scottish
HCV infected patients and to explore the effect of the carrier state on serum and liver
iron stores , and the severity of
liver disease . -
pubmed
Carriage of
HFE mutations , although frequently observed in these
HCV infected patients , does not have a role in the accumulation of
iron or the progression of
liver disease in
HCV infection . -
pubmed
Expression of
BLM ( the causative gene for
Bloom syndrome ) and screening of
Bloom syndrome . -
pubmed
The causative gene for
BS is the
BLM gene which encodes the
BLM RecQ helicase protein . -
pubmed
The detection of
BLM gene mutations for laboratory diagnosis of
BS is laborious and impractical , unless there are common mutations in a population . -
pubmed
The
BLM protein was not detected in
EBV - transformed lymphoblasts from three
BS patients . -
pubmed
However , in lymphoblasts from
BS patients no nuclear dots of the
BLM protein were detected . -
pubmed
The expression of
beta2 - adrenergic receptors (
beta2 - R ) on B lymphocytes and agonist - induced
cAMP production is reduced in
patients with
rheumatoid arthritis (
RA ) . -
pubmed
To further study functional consequences of the diminished
beta2 - R density on B lymphocytes in
RA patients , agonist - induced cell death was evaluated and compared to healthy controls . -
pubmed
B lymphocytes from
patients with
RA and healthy controls were activated with
anti - IgM - antibody . -
pubmed
Apoptotic and
necrotic cells were determined using
Annexin - V and
propidium - iodide staining . -
pubmed
However , in
RA patients the increase in cell death following
beta2 - R stimulation ( 21.8 + /- 8.9 % ) was significantly impaired ( p = 0.02 ) . -
pubmed
Our data demonstrate that
catecholamine - induced cell death after stimulation of
beta2 - R on B lymphocytes is decreased in
RA patients , possibly contributing to the pathogenesis of the disease . -
pubmed
To identify inhibitors of the intrinsic N - acetylated
alpha - linked acidic dipeptidase (
NAALADase ) activity of
prostate specific membrane antigen (
PSMA ) that may be useful for targeting imaging agents or chemotherapeutic drugs to disseminated
prostate cancer , analogs of the tetrahedral transition state for hydrolysis of the natural substrate ,
N - acetylaspartylglutamate (
NAAG ) , were synthesized . -
pubmed
Mutations in the
Recql4 gene are very likely responsible for a subset of
Rothmund - Thomson syndrome (
RTS ) cases , but until now there has been no
animal model to confirm this . -
pubmed
Knockout
mice in which the
Recql4 gene is disrupted at exons 5 - 8 exhibit
embryonic lethality at embryonic day 3.5 - 6.5 . -
pubmed
The exon 13 - deleted
Recql4 - deficient
mice are viable , but exhibit severe
growth retardation and abnormalities in several tissues , and embryonic fibroblasts show a defect in cell proliferation . -
pubmed
Abnormalities in the
Recql4 - deficient
mice are similar to those in
RTS patients , suggesting that defects in the
Recql4 gene may indeed be responsible for
RTS . -
pubmed
CD14 - positive cells cultured in the presence of PSK significantly increased the expression of
HLA class II antigen and
CD40 ; significantly increased the number and expression of
CD80- ,
CD86- and
CD83 - positive cells ; decreased
Fluorescein isothiocyanate (
FITC)-dextran uptake , augmented
IL-12 production ; augmented the allogeneic mixed lymphocyte reaction ; and induced antigen - specific
cytotoxicity . -
pubmed
To date there have been limited studies of
HSA21 gene expression in
trisomy 21 conceptuses . -
pubmed
Since non - HSA21 antioxidant genes are reported to be concomitantly upregulated in certain
DS tissues , we examined the expression of
glutathione peroxidase-1 (
GPX1 ) in control and
DS fetal organs . -
pubmed
Interestingly ,
GPX1 expression was unchanged in the majority of
DS organs and decreased in DS livers . -
pubmed
The diagnosis and treatment of
prostate cancer have been dramatically improved due to the development of
PSA screening , transrectal ultrasonography and new anti - androgen drugs , such as
LH - RH analog , with fewer side effects . -
pubmed
In the present study , we provide evidence that the
hypertrophic agonist ,
phenylephrine ( PE ) , promotes phosphorylation of
CREB in adult
rat cardiac myocytes through
alpha ( 1 )- and beta - adrenergic receptors . -
pubmed
The same pathways seem to regulate
atrial natriuretic peptide (
ANF ) mRNA expression , a highly conserved marker gene of
cardiac hypertrophy , suggesting that the PE - stimulated activation of
CREB is likely to play an important role in the
hypertrophic response . -
pubmed
with the
breast cancer cells and syngeneic / allogeneic - transfected fibroblasts modified to secrete
IL-2 survived significantly longer ( P & lt ; .005 ) than
mice in various control groups , including
mice injected i.c . -
pubmed
Botulinum toxin A for treatment of
neurogenic detrusor overactivity and
incontinence in
patients with
spinal cord lesions . -
pubmed
OBJECTIVE : To evaluate the efficacy of intravesical
botulinum toxin A (
BTA ) in the treatment of severe
neurogenic detrusor overactivity (
NDO ) with
incontinence in
patients with
spinal cord lesions (
SCLs ) . -
pubmed
Curcumin blocks
HIV protease inhibitor
ritonavir - induced
vascular dysfunction in
porcine coronary arteries . -
pubmed
BACKGROUND :
HIV protease inhibitor
ritonavir (
RTV ) is associated with many
cardiovascular complications and causes
vascular dysfunction through oxidative stress . -
pubmed
[
PPARgamma and
colon cancer ] . -
pubmed
Leptin as a common link to
obesity and
hypertension . -
pubmed
While the relevance of endogenous
leptin needs further clarification , it appears to be a potential pressure- and volume - regulating factor , and may function pathophysiologically as a common link to
obesity and
hypertension . -
pubmed
The association with
HLA - B27 is less strong in
IBD - associated
AS than in idiopathic
AS , and there is evidence for an association between
gut inflammation in
AS with the
Crohn 's - disease - related
CARD15 mutations . -
pubmed
Major advances have been made in recent years with the establishment of
anti - tumour necrosis factor (
TNF ) therapy in
AS , the other
spondyloarthritides and
IBD . -
pubmed
Anti -
TNF agents are of particular relevance to
AS patients with concomitant
IBD who are at risk of exacerbation of the underlying
bowel disease when treated with NSAIDs . -
pubmed
Plasma
retinol - binding protein-4 concentrations are elevated in
human subjects with
impaired glucose tolerance and
type 2 diabetes . -
pubmed
Retinol - binding protein-4 (
RBP4 ) , a new adipokine , was recently reported to provide a link between
obesity and
insulin resistance . -
pubmed
RESEARCH DESIGN AND METHODS : An enzyme - linked immunosorbent assay was developed to measure
human RBP4 plasma concentrations , which were then compared with various parameters related to
insulin resistance in
subjects with normal
glucose tolerance ( NGT ; n = 57 ) ,
impaired glucose tolerance (
IGT ; n = 48 ) , and
type 2 diabetes ( n = 49 ) . -
pubmed
RESULTS : Plasma
RBP4 concentrations were higher in the IGT and
type 2 diabetic groups than in the NGT group ( median 18.9 [ range 11.2 - 45.8 ] , 20.9 [ 9.9 - 48.5 ] , and 18.1 microg / ml [ 9.3 - 30.5 ] , respectively ) . -
pubmed
However , no difference was found between plasma
RBP4 concentrations in the IGT and
type 2 diabetic groups . -
pubmed
Plasma
RBP4 concentrations were found to be associated with sex , waist circumference , fasting plasma
glucose , and
insulin resistance . -
pubmed
CONCLUSIONS : Plasma
RBP4 concentrations were found to be elevated in
subjects with
IGT or
type 2 diabetes and to be related to various clinical parameters known to be associated with
insulin resistance . -
pubmed
However , both
MAPK and
NF - kappaB are also stimulated by exercise , which promotes improvements in fuel homeostasis and can prevent skeletal
muscle atrophy . -
pubmed
RESULTS :
Lipoatrophy was associated with higher
triglycerides ( 330 vs 133 mg / dl , p = 0.0003 ) , lower
HDL ( 33 vs 48 mg / dl , p = 0.02 ) , and a greater frequency of
hypercholesterolemia ( total
cholesterol & gt ; 200 mg / dl ; 64 % vs 23 % , p & lt ; 0.03 ) . -
pubmed
Adiponectin was 53 % lower in
patients with
lipodystrophy ( 6.9 microg / ml vs 14.8 microg / ml , p = 0.005 ) , however there was no difference in the inflammatory markers soluble
TNFa receptor 2 or
interleukin 6 . -
pubmed
[ Development of a novel
ADAMTS13 activity assay for diagnosis of
TMA and criteria for judgment of platelet transfusion ] . -
pubmed
ADAMTS13 specifically cleaves unusually large
von Willebrand factor (
VWF ) multimers , which induce platelet
thrombi formation under high shear stress . -
pubmed
The determination of plasma levels of
ADAMTS13 activity is prerequisite for a differential diagnosis of
thrombotic microangiopathies (
TMAs ) . -
pubmed
The plasma antigen level of
ADAMTS13 has generally good correlate to the plasma activity , but the several samples from acquired
TTP patients with below 3 % activity showed apparently high antigen level from 5 to 30 % . -
pubmed
[ Expression of
focal adhesion kinase in cardiac myocytes of
hypertrophic ventricle ] . -
pubmed
OBJECTIVES : To investigate the role of
focal adhesion kinase (
FAK ) in the pathogenesis of
cardiac hypertrophy induced by
hypertension . -
pubmed
METHODS : Using immunofluorescent labeling , confocal microscopy and Western blotting , the expression and subcellular localization of
FAK in the cardiac myocytes of left ventricle were determined in 2 , 6 , 12 , and 18 month - old
rats with spontaneously
hypertensive heart failure (
SHHF ) along with age - matched control Wistar - Kyoto ( WKY )
rats . -
pubmed
CONCLUSIONS :
FAK may play a role in the cell signaling transduction leading to
cardiac hypertrophy , presumably through regulations of hypertrophic gene transcription and RNA processing . -
pubmed
Pharmacological subversion of the
S1P rheostat is proving to be clinically efficacious in
multiple sclerosis , and both the scope and limitations of therapeutic modulation of the
S1P axis in immunotherapy are becoming clearer as understanding of the integrated chemical physiology of the
S1P system emerges . -
pubmed
To avoid
ovarian dysfunction , synthetic peptides corresponding to
ZP glycoproteins have been proposed as candidate immunogens . -
pubmed
CONCLUSION : The observed degree of coding sequence homology in
LRP5 led us to expect that the
baboon may serve as a useful model for future research into the role(s ) of this gene in
primate metabolic diseases . -
pubmed
While baseline learning and memory were unaffected by reduction of gamma2 containing
GABA ( A ) receptors ,
ethanol dose - dependently
impaired spatial memory equally in gamma2 heterozygous knockouts and wild type littermate controls . -
pubmed
The conversion of the
prion protein (
PrP ) from its cellular form ,
PrPC , to its pathogenic scrapie form ,
PrPSc , is a key event in
neurodegenerative transmissible spongiform encephalopathies such as
Creutzfeldt - Jakob disease (
CJD ) . -
pubmed
One working hypothesis for
TSE causation is that oligomeric forms of
PrP are the proximate
neurotoxic agents . -
pubmed
To gain insights into these intermediates , we have studied
PrP125 - 228 and its
CJD - causing T183A variant in their monomer and dimer forms by means of coarse - grained protein molecular dynamics simulations . -
pubmed
Neutrophil gelatinase - associated lipocalin (
NGAL ) in
human neoplasias : a new protein enters the scene . -
pubmed
The small 25 kDa peptide ,
neutrophil gelatinase - associated lipocalin (
NGAL ) , first known as an antibacterial factor of natural immunity , and an acute phase protein , is currently one of the most interesting and enigmatic proteins involved in the process of
tumor development . -
pubmed
The aim of the present review is to point out the main contradictory , sometimes even paradoxical , effects attributed to
NGAL in
human neoplasias . -
pubmed
For instance , acting as an intracellular
iron carrier and protecting
MMP9 from proteolytic degradation ,
NGAL has a clear pro - tumoral effect , as has already been observed in different
tumors ( e.g. -
pubmed
Moreover , in
thyroid carcinomas ,
NGAL is strongly induced by
NF - kB , an important factor involved both in
tumor growth and in the link between chronic
inflammation and neoplastic development . -
pubmed
However , on the contrary , some studies have demonstrated that
NGAL can inhibit the pro - neoplastic factor
HIF-1alpha ,
FA - Kinase phosphorylation and also
VEGF synthesis , thus suggesting that , in alternative conditions ,
NGAL also , paradoxically , has an anti - tumoral and anti - metastatic effect in
neoplasias of , for example , the colon , ovary and pancreas . -
pubmed
Because inheritance of the
apoE4 allele is the strongest known genetic risk factor for
Alzheimer disease , the reduced neuroprotection afforded by
apoE4 - containing
LpE might contribute to the neurodegeneration characteristic of this disease . -
pubmed
However , a completely different mechanism may be operating in major
depression , where the increased levels of glucocorticoid hormones are conceptualized as driven by an impairment in
GR function ( glucocorticoid resistance ) , and therefore as a " compensatory " mechanism . -
pubmed
{ alpha } 7 - nAChR - mediated suppression of hyperexcitability of colonic dorsal root ganglia neurons in experimental
colitis . -
pubmed
Overall , our findings suggest that
nicotine at low 1 microM concentration suppresses in vitro hyperexcitability of inflamed colonic DRG neurons in a
mouse model of acute colonic
inflammation via activation of
alpha ( 7 )- nAChRs . -
pubmed
Changes in hormones , including
testosterone ,
estrogen ,
cortisol ,
vasopressin , and
prolactin , during the postpartum period in fathers may be biological risk factors in paternal
PPD . -
pubmed
We and others have previously shown that hyperactivation of the
c - Kit pathway in an
Nf1 haploinsufficient microenvironment is required for both
tumor formation and progression . -
pubmed
These studies identify the
p21 ( Ras )- PI3 K pathway as a major regulator of the gain in
Nf1(+/- ) mast cell degranulation in
neurofibromas . -
pubmed
Collectively , these studies identify both
c - Kit and
PI3 K as molecular targets that modulate mast cell functions in cases of
NF1 . -
pubmed
Previous studies of the association of the C17 T polymorphism of the
mu opiate receptor gene with
substance dependence compared cases with
substance dependence to controls and usually found no significant association . -
pubmed
Angiotensin - converting enzyme 2 is a key modulator of the
renin -
angiotensin system in
cardiovascular and renal disease . -
pubmed
RECENT FINDINGS :
ACE2 deficiency is associated with elevated tissue and circulating levels of
angiotensin II and reduced levels of
angiotensin 1 - 7 . -
pubmed
In
atherosclerosis - prone
apolipoprotein E knockout
mice ,
ACE2 deficiency results in augmented
vascular inflammation and an inflammatory response that contributes to increased
atherosclerotic plaque formation . -
pubmed
In the kidney ,
ACE2 deficiency is associated with progressive
glomerulosclerosis . -
pubmed
Interventions such as
ACE2 replenishment or augmentation of its actions have proven successful in reducing
hypertension ,
plaque accumulation , and renal and
cardiac damage in a range of different models . -
pubmed
SUMMARY : Repletion of
ACE2 's activities offers a new strategy to complement current clinical interventions in treating
hypertension ,
renal and cardiovascular disease . -
pubmed
Prognostic significance of
matrix metalloproteinase-20 overexpression in
laryngeal squamous cell carcinoma . -
pubmed
CONCLUSION :
Matrix metalloproteinase ( MMP )- 20 is overexpressed in
laryngeal squamous cell carcinoma (
LSCC ) compared with the adjacent
normal laryngeal epithelium and
MMP-20 plays a role in lymph node metastasis . -
pubmed
All the findings indicate that
MMP-20 may play a role in the initiation and progression of
LSCC . -
pubmed
OBJECTIVE : The
MMPs are a gene family of zinc - dependent endopeptidases that have been implicated in
tumor invasion and metastasis , and
MMP-20 is a new member of the
MMP family . -
pubmed
The purpose of this study was to investigate whether
MMP-20 is overexpressed in
human LSCC and , if so , the significance of its overexpression in relation to clinical parameters . -
pubmed
RESULTS : We found that
MMP-20 is overexpresssed in
LSCC compared with the adjacent
normal laryngeal epithelium . -
pubmed
Invariant NKT cells producing
IL-4 or
IL-10 , but not
IFN - gamma , inhibit the Th1 response in experimental
autoimmune encephalomyelitis , whereas none of these cells inhibits the Th17 response . -
pubmed
Invariant NKT ( iNKT ) cells prevent
EAE in an
IL-4- , IL-10- , and
IFN - gamma - dependent manner . -
pubmed
However , which of the iNKT cell - produced
cytokines regulates the Th1 or Th17 response in
EAE remains unclear . -
pubmed
Clinical scores for
EAE ,
IL-17 , and
IFN - gamma transcript levels , and
IL-17- or
IFN - gamma - expressing
CD4(+ ) T cell percentages in the CNS and draining lymph nodes were higher in Jalpha18(-/- ) than in B6
mice , but all of these parameters in the CNS were reduced by the adoptive transfer of
wild - type or IFN - gamma - deficient iNKT cells into the Jalpha18(-/- )
mice before immunization . -
pubmed
Taken together ,
IL-4- and
IL-10 - producing iNKT cells inhibit the Th1 cell response , but not the Th17 cell response , although wild - type iNKT cells suppress both the Th1 and Th17 responses in the CNS during
EAE . -
pubmed
Moreover ,
IFN - gamma - producing iNKT cells have a minimal role in the regulation of the Th1 and Th17 responses in
EAE . -
pubmed
Association of
CYP19 gene polymorphism with
vertebral fractures in Japanese postmenopausal women . -
pubmed
We explored the relationship between
CYP19 polymorphisms and
vertebral fractures in postmenopausal Japanese women . -
pubmed
The C allele rs2470152 was significantly associated with increased risk of
vertebral fractures ( P = 0.04 ) , whereas none of the
CYP19 polymorphisms showed differences in sex
steroid levels between subjects with and without
fractures . -
pubmed
Allelic variants of
aromatase genes appear to interact to influence the risk of
vertebral fractures in postmenopausal Japanese women . -
pubmed
Platelet adenosine diphosphate ( ADP ) receptor antagonists (
ticlopidine ,
clopidogrel ,
prasugrel , and
ticagrelor ) are a major advance in the treatment of
atherothrombotic diseases , especially
acute coronary syndromes (
ACS ) . -
pubmed
Endothelin B receptor agonist ,
IRL-1620 , provides long - term neuroprotection in
cerebral ischemia in
rats . -
pubmed
We have earlier shown that stimulation of
endothelin B receptors by
IRL-1620 provides significant neuroprotection at 24h following
cerebral ischemia . -
pubmed
This study was designed to determine the effect of
IRL-1620 on neurological functions , infarct volume , oxidative stress , and
endothelin receptors following permanent
middle cerebral artery occlusion for 7 days . -
pubmed
No change in expression of
endothelin A receptor was observed 7 days after induction of
cerebral ischemia in vehicle or
IRL-1620 treated
rats . -
pubmed
Selective
endothelin B receptor activation may prove to be a novel therapeutic target in the treatment of
cerebral ischemia . -
pubmed
Challenges and opportunities in the targeting of
fibroblast growth factor receptors in
breast cancer . -
pubmed
Activation of the
fibroblast growth factor receptor pathway is a common event in many
cancer types . -
pubmed
Here we review the role of
fibroblast growth factor receptor signalling in
breast cancer , from SNPs in
FGFR2 that influence
breast cancer risk and SNPs in
FGFR4 that associate with
breast cancer prognosis , and potential therapeutic targets such as receptor amplification and aberrant autocrine and paracrine ligand expression . -
pubmed
Apolipoprotein E regulation of myeloid cell plasticity in
atherosclerosis . -
pubmed
PURPOSE OF REVIEW :
Apolipoprotein ( apo ) E is a multifunctional protein that has long been recognized for its ability to safeguard against
atherosclerosis . -
pubmed
Among its pleiotropic roles known to suppress
atherosclerosis , mechanisms by which
apoE regulates cells of the immune system have remained elusive . -
pubmed
Because
atherosclerosis is a
chronic inflammatory disease that remains on the rise , understanding in more detail how
apoE controls immune cell activation and function is of much interest . -
pubmed
By promoting cellular
cholesterol efflux in a cell autonomous manner and through its ability to enhance HDL function in
hyperlipidemic plasma ,
apoE is now known to suppress
atherosclerosis by controlling myeloid cell proliferation , monocyte activation and their capacity to infiltrate the vascular wall . -
pubmed
Lastly , the structural basis for
apoE isoform - specific effects in macrophage dysfunction and
atherosclerosis susceptibility is beginning to emerge . -
pubmed
SUMMARY : Collectively , these findings introduce a new dimension to our understanding of how
apoE links lipoprotein biology to monocyte and macrophage function in
atherosclerosis susceptibility . -
pubmed
STIM1 and
STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland
autoimmune disease ,
Sjogren ' s syndrome . -
pubmed
Here we report that
mice with T - cell - targeted deletion of
Stromal Interaction Molecule ( STIM ) 1 and
STIM2 [ double - knockout ( DKO ) ]
mice develop spontaneous and severe
pSS - like autoimmune disease , displaying major hallmarks of the disease . -
pubmed
Sjogren ' s syndrome - specific autoantibodies (
SSA / Ro and
SSB /
La ) were detected in the serum , and progressive salivary gland destruction and loss of fluid secretion were also seen . -
pubmed
Importantly , we report that peripheral blood mononuclear cells as well as lymphocytic infiltrates in submandibular glands from
patients with
pSS demonstrated significant reductions in
STIM1 and
STIM2 proteins . -
pubmed
Thus , deficiency of
STIM1 and
STIM2 proteins in T cells , and consequent defects in
Ca ( 2 + ) signaling , are associated with
salivary gland autoimmunopathy in DKO
mice and
pSS patients . -
pubmed
These data reveal a previously unreported link between
STIM1 and
STIM2 proteins and
pSS . -
pubmed
Curcumin reduces
cisplatin - induced
neurotoxicity in
NGF - differentiated
PC12 cells . -
pubmed
We also investigated whether
curcumin affects
cisplatin effectiveness by analyzing the modulation of
p53 gene expression and its effect on
cisplatin cytotoxicity in
HepG2 tumor cells . -
pubmed
Curcumin neither suppressed
p53 mRNA transcription nor protected tumor cells against
cisplatin cytotoxicity . -
pubmed
The
cardiotoxicity of
DOX formulations was evaluated by
serum creatine kinase MB (
CKMB ) activity in both
animal groups before and after drug administration . -
pubmed
Mutations in
STT3A and
STT3B cause two
congenital disorders of glycosylation . -
pubmed
We describe two unreported types of
congenital disorders of glycosylation (
CDG ) which are caused by mutations in different isoforms of the catalytic subunit of the
oligosaccharyltransferase (
OST ) . -
pubmed
Downregulation of
GRHL2 inhibits the proliferation of
colorectal cancer cells by targeting
ZEB1 . -
pubmed
Previous reports have associated
GRHL2 with
tumor progression . -
pubmed
However , the biological role of
GRHL2 in human
colorectal cancer (
CRC ) has not been explored . -
pubmed
We examined the expression of
GRHL2 in 75
CRC samples , as well as the paired
non - tumor tissues , by immunohistochemistry , qRT - PCR , and western blot analysis . -
pubmed
We performed lentivirus - mediated shRNA transfection to knock down
GRHL2 gene expression in
HT29 and
HCT116 CRC cells . -
pubmed
Moreover , we transiently silenced
ZEB1 expression in
GRHL2 - knockdown
CRC cells using specific shRNA , and then examined the effects on
GRHL2 and
E - cadherin expression , as well as cell proliferation . -
pubmed
Herein , we demonstrated that enhanced
GRHL2 expression was detected in
CRC , and correlated with higher levels of
Ki-67 staining , larger
tumor size , and advanced clinical stage . -
pubmed
Knocking down
GRHL2 in
HT29 and
HCT116 CRC cells significantly inhibited cell proliferation by decreasing the number of cells in S phase and increasing that in the G 0 / G 1 phaseof the cell cycle . -
pubmed
Collectively , our study has identified
ZEB1 as a target of
GRHL2 and suggested a reciprocal
GRHL2 -
ZEB1 repressive relationship , providing a novel mechanism through which proliferation may be modulated in
CRC cells . -
pubmed
KRT9 gene mutation as a reliable indicator in the prenatal molecular diagnosis of
epidermolytic palmoplantar keratoderma . -
pubmed
EPPK is generally caused by mutations of the
KRT9 gene . -
pubmed
More than 26
KRT9 gene mutations responsible for
EPPK have been described (
Human Intermediate Filament Database , www.interfil.org ) , and many of these variants are located within the highly - conserved coil 1A region of the alpha - helical rod domain of
keratin 9 . -
pubmed
In the present study , we performed amniotic fluid - DNA - based prenatal testing for three at - risk pregnant
EPPK women from three unrelated southern Chinese families who carried the
KRT9 missense mutations p. Arg163Trp and p. Arg163Gln , and successfully helped two families to bear normal daughters . -
pubmed
Toll - like receptors and
cancer , particularly
oral squamous cell carcinoma . -
pubmed
Once activated , they initiate signaling pathways leading to the release of
cytokines and
chemokines , which recruit immune cells inducing further
cytokine production , the production of angiogenic mediators and growth factors , all of which may influence
tumor progression . -
pubmed
This paper examines the actions of
TLRs in carcinogenesis with particular emphasis on their role in
oral squamous cell carcinoma . -
pubmed
A great amount of factors are implicated in the pathogenesis of
VVs , including changes in hydrostatic pressure ,
valvular incompetence ,
deep venous obstruction , ineffective function of calf muscle pump , biochemical and structural alterations of the vessel wall ,
extracellular matrix abnormalities , impaired balance between growth factors or
cytokines , genetic alterations , and several other mechanisms . -
pubmed
Amyloid - beta and
Tau Dynamics in
Human Brain Interstitial Fluid in
Patients with Suspected Normal Pressure
Hydrocephalus . -
pubmed
BACKGROUND :
Amyloid - beta (
Abeta1 - 42 ) , total
tau (
T - tau ) , and phosphorylated
tau ( P - tau181 ) in the cerebrospinal fluid ( CSF ) are the most promising biomarkers of
Alzheimer ' s disease (
AD ) . -
pubmed
CONCLUSIONS : This is the first study to report ISF
Abeta and
tau levels in the
human brain without significant
brain injury . -
pubmed
Peroxisome proliferator - activated receptor - gamma agonist inhibits the
mammalian target of rapamycin signaling pathway and has a protective effect in a
rat model of
status epilepticus . -
pubmed
Peroxisome proliferator - activated receptor gamma (
PPAR - gamma ) has a protective role in several
neurological diseases . -
pubmed
The present study investigated the effect of the
PPAR - gamma agonist ,
pioglitazone , on the
mammalian target of rapamycin (
mTOR ) signaling pathway in a
rat model of
pentylenetetrazol (
PTZ)-induced
status epilepticus (
SE ) . -
pubmed
First , the course of activation of the
mTOR signaling pathway in
PTZ - induced
SE was examined to determine the time - point of peak activity , as reflected by phopshorylated ( p)-
mTOR /
mTOR and
p - S6 / S6 ratios . -
pubmed
The levels of the
interleukin ( IL )- 1beta and
IL-6 inflammatory
cytokines were detected using ELISA , and
neuronal loss was observed via Nissl staining . -
pubmed
Compared with the vehicle treated -
SE group , pretreatment with
pioglitazone was associated with the loss of fewer neurons , lower levels of
IL-1beta and
IL-6 , and inhibition of the activation of the
mTOR signaling pathway . -
pubmed
Therefore , the
mTOR signaling pathway was activated in the
PTZ - induced
SE rat model , and the
PPAR - gamma agonist ,
pioglitazone , had a neuroprotective effect , by inhibiting activation of the
mTOR pathway and preventing the increase in the levels of
IL-1beta and
IL-6 . -
pubmed
Serum
immunoglobulin G concentrations against
hepatitis E were determined using the enzyme linked immunosorbent assay method . -
pubmed
BACKGROUND :
Adiponectin levels have been shown to be associated with
colorectal cancer (
CRC ) . -
pubmed
Therefore , we investigated the potential for a genetic association between
T - cadherin and
CRC risk . -
pubmed
Study results revealed that rs3865188 in the 5 ' flanking region of the
T - cadherin gene (
CDH13 ) was significantly associated with
CRC ( p = 0.0474 ) . -
pubmed
In addition , the interaction between
CDH13 and the
adiponectin gene (
APN ) for
CRC risk was investigated using a logistic regression analysis . -
pubmed
Furthermore , the plasma
adiponectin level showed a correlation with the gene - gene interaction , and the group with the highest risk for
CRC had the lowest
adiponectin level ( median , 4.8 mug / mL for the TT / GG genotype vs.7.835 mug / mL for the AA / AA genotype , p = 0.0017 ) . -
pubmed
CONCLUSIONS : The present study identified a new genetic factor for
CRC risk and an interaction between
CDH13 and
APN in
CRC risk . -
pubmed
RESULTS : The results indicated that
minocycline inhibited
inflammation , decreased the expression of
interleukin-1beta ,
tumor necrosis factor - alpha , and
metalloproteinase - 9 , and
squamous metaplasia features such as hyperproliferation and abnormal epidermal differentiation of conjunctival epithelium . -
pubmed
Statistical analyses were performed using Plink and R. RESULTS :
VKORC1 and
CYP2C9 were the major genetic determinants of
warfarin MWD and
SMWD , with
CYP4F2 having a smaller effect . -
pubmed
Also , serum
ferritin level was significantly higher in
RAS patients ( p<0.008 ) . -
pubmed
In the prenatal diagnosis of
Gaucher disease (
GD ) ,
glucocerebrosidase (
GBA ) activity is measured with fetal cells , and gene analysis is performed when pathogenic mutations in GBA are identified in advance . -
pubmed
Serum
IgG and risk of exacerbations and hospitalizations in
chronic obstructive pulmonary disease . -
pubmed
Insulin therapy improves health outcomes in patients with
CF . -
pubmed
Family - based analysis of
GGT1 and
HNF1A gene polymorphisms in patients with
polycystic ovary syndrome . -
pubmed
Previous studies indicate that genes
GGT1 and
HNF1A may contribute to the abnormal
glucose metabolism and altered lipid profile that are important clinical features of
PCOS . -
pubmed
In the current study , the correlation between polymorphisms in the
GGT1 and
HNF1A genes and
PCOS was explored . -
pubmed
A total of 310 family trios were studied and the transmission disequilibrium test ( TDT ) was used to assess the linkage between
PCOS and three single - nucleotide polymorphisms ( SNP ) ( rs4820599 of
GGT1 , rs7305618 and rs2393791 of
HNF1A ) . -
pubmed
None of the three SNP markers showed significant transmission disequilibrium in
PCOS family trios ( rs4820599 :
GGT1 gene , chi2 = 1.067 ; rs7305618 :
HNF1A gene , chi2 = 0.013 ; rs2393791 :
HNF1A gene , chi2 = 0.031 ) . -
pubmed
In conclusion , no significant evidence supported a relationship between genes
GGT1 and
HNF1A and
PCOS in the current family trios . -
pubmed
Despite the very low quality of evidence , restoring normoxia in patients with
hypoxia is recommended , and blood pressure lowering drugs and treating
hyperglycaemia with
insulin should be avoided . -
pubmed
Our objective was to determine the rate of
acromegaly comorbidities once hypersecretion of
growth hormone is controlled . -
pubmed
Our main outcome measures were the prevalence of major metabolic complications of
acromegaly (
diabetes ,
hypertension ,
low - density lipoprotein cholesterol ,
triglycerides ) at diagnosis and last follow - up in comparison with French epidemiological data . -
pubmed
We describe the performance of the VENTANA
PD - L1 ( SP142 ) Assay in terms of specificity , sensitivity , and the ability to stain both
tumor cells ( TC ) and tumor - infiltrating immune cells ( IC ) , in
NSCLC and
UC tissues . -
pubmed
The reader precision , repeatability and intermediate precision , interlaboratory reproducibility , and the effectiveness of pathologist training on the assessment of
PD - L1 staining on both
TC and IC were evaluated . -
pubmed
We detail the analytical validation of the VENTANA PD - L1 ( SP142 ) Assay for
PD - L1 expression in
NSCLC and
UC tissues and show that the assay reliably evaluated staining on both TC and IC across multiple expression levels / clinical cut - offs . -
pubmed
In addition , pathologists met the predefined training criteria ( & gt;=85.0 % overall percent agreement ) for the assessment of
PD - L1 expression in
NSCLC and
UC tissues with an average overall percent agreement & gt;=95.0 % . -
pubmed
Occludin protein expression in
human cervical cancer and its association with
patient 's clinical characteristics . -
pubmed
Objective : The objective of the study was to investigate the expression of the tight junction protein
occludin ( encoded by
OCLN gene ) in
human cervical cancer and its association with clinical features of
patients . -
pubmed
Immuno - histochemical assay was applied to examine the expression of
occludin protein in 61
cervical cancer tissues and matched adjacent
cancer normal tissues . -
pubmed
Results :
Occludin protein was mainly expressed in cell membranes and cytoplasm of both the
cervical cancer cell and the normal cells . -
pubmed
In
cervical cancer tissues , the positive rate of
occludin protein was 77.05 % ( 47/61 ) , whereas , in adjacent
normal tissues of the
cancer , the positive rate was 96.72 % ( 59/61 ) . -
pubmed
Therefore , the positive rate of
occludin in
cervical cancer tissues was significantly lower than that of the adjacent
cancer tissues ( P & lt ; 0.05 ) . -
pubmed
Occludin protein expression level was not significantly correlated with the age ( P & gt ; 0.05 ) ,
tumor size ( P & gt ; 0.05 ) , International Federation of Gynecology and Obstetrics staging ( P & gt ; 0.05 ) , pathological grades ( P & gt ; 0.05 ) , and lymph node metastasis ( P & gt ; 0.05 ) of the
patients . -
pubmed
Conclusion :
Occludin protein may contribute to the development of
cervical cancer . -
pubmed
Synthetic immunocortin in concentration ~ 10 - 9 M suppresses phagocytosis in peritoneal macrophages , ConA - dependent blast transformation of
rat lymphocytes , exhibits
ACTH - like neurotropic activity and was suggested as a potential drug for treatment of a
multiple sclerosis (
MS ) . -
pubmed
The attenuation of
HIV-1 Tat - induced
neurotoxicity by
Salvianic acid A and Danshen granule . -
pubmed
The
neurotoxicity of
HIV-1 Tat protein contributes significantly to the pathogenesis of
HAND , and hence the attractive therapeutic strategies focusing on
Tat - induced
neurotoxicity are warranted . -
pubmed
However , the protective effects of
Salvianic acid A and Danshen granule on
Tat - induced
neurotoxicity remain unknown . -
pubmed
In conclusion , this study demonstrated that
Salvianic acid A and Danshen granule provides substantial neuroprotection against
Tat - induced
neurotoxicity , which may be new therapeutic agent in
Tat induced
HAND or
neurodegenerative diseases . -
pubmed
Intravenous
tissue plasminogen activator for
ischemic stroke in early pregnancy dosed by actual body weight . -
pubmed
Methods : Here , we present a
patient who received intravenous
tissue plasminogen activator in the emergency department during her first trimester of pregnancy for the treatment of an
acute ischemic stroke . -
pubmed
Post
tissue plasminogen activator imaging revealed recanalization of the vessel and the
patient 's National Institutes of Health
Stroke Scale was 0 . -
pubmed
Conclusion : We present positive outcomes of a mother and fetus after receipt of intravenous
tissue plasminogen activator using actual body weight during the first trimester of pregnancy for an
acute ischemic stroke . -
pubmed
Recently , damage to ER - mitochondria signaling involving disruption of the
VAPB -
PTPIP51 tethers has been linked to the pathogenic process in
Parkinson ' s disease ,
fronto - temporal dementia (
FTD ) and related
amyotrophic lateral sclerosis (
ALS ) . -
pubmed
Loss of neuronal synaptic function is a key feature of
Parkinson ' s disease and
FTD /
ALS but the roles that ER - mitochondria signaling and the
VAPB -
PTPIP51 tethers play in synaptic function are not known . -
pubmed
Our results reveal a new role for the
VAPB -
PTPIP51 tethers in neurons and suggest that damage to ER - mitochondria signaling contributes to
synaptic dysfunction in
Parkinson ' s disease and
FTD /
ALS . -
pubmed
Here , we demonstrate that a luciferase reporter assay , in combination with ChIP - qPCR , reliably separates pathogenic
ZBTB24 missense variants in the context of
immunodeficiency , centromeric instability ,
facial anomalies (
ICF ) syndrome from natural variants in healthy individuals and patients of other diseases . -
pubmed
Application of our assay to two published
ZBTB24 missense VUSs indicates that they are likely not to cause
ICF2 syndrome . -
pubmed
Furthermore , we show that rare gnomAD
ZBTB24 missense variants in key residues of the C2H2 - ZF domain lead to a loss of function phenotype that resembles
ICF2 , suggesting that these
individuals are carriers of
ICF syndrome . -
pubmed
The loss of
ARNT /
HIF1beta in male pancreatic beta - cells is protective against high fat diet - induced
diabetes . -
pubmed
The transcription factor
aryl hydrocarbon receptor nuclear translocator (
ARNT)/
hypoxia - inducible factor ( HIF )- 1beta (
ARNT /
HIF1beta ) plays a key role in maintaining beta - cell function and has been shown to be one of the most down regulated transcription factors in islets from
type 2 diabetic patients . -
pubmed
In order to gain a better understanding of the role of
ARNT /
HIF1beta in the development of
diabetes , we placed control ( + /+/Cre ) and beta - cell specific
ARNT /
HIF1beta knockout ( fl / fl / Cre )
mice on a high fat ( HF ) diet . -
pubmed
Overall ,
mice lacking
ARNT /
HIF1beta in beta - cells have altered lipid signalling in vivo and are resistant to a
HF diets ability to induce
diabetes . -
pubmed
Long noncoding RNA
GAS6 -
AS2 sponges microRNA-493 , thereby enhancing the malignant characteristics of
breast cancer cells via upregulation of
FUT4 . -
pubmed
Long noncoding RNA ( lncRNA )
GAS6 -
AS2 serves as an oncogenic lncRNA in various types of
human cancer . -
pubmed
In this study , we attempted to examine the functions of
GAS6 -
AS2 in
breast cancer (
BC ) and explore the potential mechanisms involved . -
pubmed
Reverse - transcription quantitative PCR was carried out to determine
GAS6 -
AS2 expression in
BC tissues and cell lines . -
pubmed
Multiple functional experiments , including a Cell Counting Kit-8 assay , Transwell migration and invasion assays , and an in vivo
nude - mouse xenograft experiment , were conducted to evaluate the effects of
GAS6 -
AS2 in
BC cells . -
pubmed
GAS6 -
AS2 expression was high in
BC tumors , manifesting a strong correlation with
tumor size , lymph node metastasis , TNM stage , and shorter overall survival in
patients with
BC . -
pubmed
A knockdown of
GAS6 -
AS2 restricted BC cell proliferation , migration , and invasion in vitro and retarded
tumor growth in vivo . -
pubmed
Either miR-493 inhibition or
FUT4 upregulation abrogated the consequences of
GAS6 -
AS2 knockdown in
BC cells . -
pubmed
These results revealed that
GAS6 -
AS2 sponges miR-493 to enhance the malignant characteristics of
BC in vitro and in vivo by increasing
FUT4 expression . -
pubmed
[
IgA vasculitis with massive
hemorrhage from the jejunum after
steroid administration ] . -
pubmed
Administration of
steroids or
factor XIII is recommended for
patients with severe
abdominal pain refractory to conservative management . -
pubmed
Our objective was to recruit patients with the
OFD1 clinical phenotype without genetic confirmation , aiming to identify genetic variants in the
OFD1 gene . -
pubmed
CONCLUSIONS : These new genetic variants will add to the spectrum of known
OFD1 mutations associated with the
OFD1 disorder . -
pubmed
Effect of
Cinacalcet on the Redox Status of
Albumin in
Secondary Hyperparathyroidism Patients Receiving Hemodialysis . -
pubmed
Cinacalcet is a calcimimetic that permits impaired endothelial functions to be recovered via inhibiting
parathyroid hormone (
PTH ) production in
SHPT patients . -
pubmed
The purpose of this study was to examine the effect of
cinacalcet on the redox state of
human serum albumin (
HSA ) , a reliable marker for assessing endothelial oxidative damage in
SHPT patients who were receiving hemodialysis . -
pubmed
Moreover , the radical scavenging abilities of
HSA that was isolated from
SHPT patients were increased by
cinacalcet , suggesting the recovery of the impaired vascular anti - oxidant ability . -
pubmed
Interestingly , the oxidized
albumin ratio in
SHPT patients was significantly higher than that in hemodialysis
patients . -
pubmed
It therefore appears that
PTH may induce oxidative stress in
SHPT patients . -
pubmed
The radiotherapy - induced
tumors were five
sarcomas , one of which was a well - differentiated angiosarcomatous
vascular lesion with negative
c - Myc ( benign lesion ) , and the remaining
patient had
basal cell carcinoma associated with radiotherapy . -
pubmed
Recently , various studies have shown that
angiotensin - converting enzyme 2 (
ACE2 ) acts as the " doorknob " that can be bound by the spike protein of
severe acute respiratory syndrome coronavirus 2 (
SARS - CoV-2 ) , which conduces to its entrance to the host cells , and plays an important role in
corona virus disease 2019 ( COVID-19 ) . -
pubmed
6 - Hydroxyindole is an endogenous long - lasting
OATP1B1 inhibitor elevated in
renal failure patients . -
pubmed
The hepatic uptake transporter
organic anion transporting polypeptide ( OATP ) 1B1 is inhibited by some uremic toxins ; however , direct inhibition can only partially explain the delayed systemic elimination of substrate drugs in
renal failure patients . -
pubmed
Plasma concentration of
6 - hydroxyindole in
renal failure patients increased as renal function decreased , but might be insufficient to exhibit potent
OATP1B1 inhibition . -
pubmed
In conclusion ,
6 - hydroxyindole is an endogenous long - lasting
OATP1B1 inhibitor with elevated plasma concentrations in
renal failure patients . -
pubmed
In conclusion ,
CTNNB1 mutations and a chr6 copy number loss are likely the causative mutations underlying the tumorigenesis of
DT while the gene expression profiles may help to differentiate patients who would be good candidates for wait - and - see management and those who might benefit from additional systemic or radiation therapies . -
pubmed
LncRNA
PCAT1 Interacts with
DKC1 to Regulate Proliferation , Invasion and Apoptosis in
NSCLC Cells via the
VEGF /
AKT /
Bcl2 /
Caspase9 Pathway . -
pubmed
The lncRNA
prostate cancer associated transcript 1 (
PCAT1 ) has been involved in tumorigenesis of multiple
malignant solid tumors , but it is largely unknown that what is the role of lncRNA -
PCAT1 and how it functions in the progression of
lung cancer . -
pubmed
Herein , we observed that lncRNA
PCAT1 expression was upregulated in both
human NSCLC tissues and cell lines , which was determined by qualitative polymerase chain reaction analysis . -
pubmed
The results showed that
PCAT1 not only promoted
NSCLC cell proliferation and invasion but also inhibited cell apoptosis . -
pubmed
Then , RNA pull - down assays with biotinylated probes and transcripts both confirmed that
PCAT1 directly bounds with
DKC1 that could also promote
NSCLC cell proliferation and invasion and inhibit cell apoptosis . -
pubmed
Furthermore ,
PCAT1 and
DKC1 activated the
vascular endothelial growth factor (
VEGF)/
protein kinase B (
AKT)/
Bcl-2 /
caspase9 pathway in
NSCLC cells , and inhibition of
epidermal growth factor receptor ,
AKT , or
Bcl-2 could eliminate the effect of
PCAT1 /
DKC1 co - overexpression on
NSCLC cell behaviors . -
pubmed
In conclusion , lncRNA
PCAT1 interacts with
DKC1 to regulate proliferation , invasion , and apoptosis in
NSCLC cells via the
VEGF /
AKT /
Bcl-2 /
caspase9 pathway . -
pubmed
Use of
AMH in the Differential Diagnosis of
Anovulatory Disorders Including
PCOS . -
pubmed
Since the historical use of
gonadotrophin and
estradiol levels to define the different
anovulatory disorders has shown some limitations , the use of other markers such as anti - mullerian hormone (
AMH ) has been proposed . -
pubmed
This review addresses the role of
AMH in the differential diagnosis of
anovulatory disorders , especially focusing on its value in the prognostic characterization of their severity . -
pubmed
Renal renin release in
patients with
essential arterial hypertension and with
unilateral renal artery stenosis . -
pubmed
Coexistence between
CGRP and
substance P ( SP ) occurs ,
SP being present in about one quarter of the
CGRP - immunoreactive neurons and
CGRP being localized in a little more than half of the
SP - immunoreactive neurons . -
pubmed
Expression of hepatic mRNAs for
insulin - like growth factors - I and - II during the development of
hypothyroid rats . -
pubmed
In vivo effects of recombinant
human interleukin 6 , alone or in combination with local irradiation , on
tumor growth in
Lewis lung carcinoma - bearing mice . -
pubmed
Lewis lung carcinoma ( LLC )- bearing mice were used as a
mouse model to evaluate effects of recombinant
human ( rh )
interleukin ( IL ) 6 and local X - irradiation ( LR ) on the growth of primary
tumors and lung metastases . -
pubmed
with LLC
tumor cells and then treated with
rhIL-6 ( 100 ng / dose ) s.c . -
pubmed
The size of the primary
tumor and numbers of lung metastases were reduced by
rhIL-6 . -
pubmed
Prolonged survival time was observed only in
tumor - bearing
mice treated with
rhIL-6 in combination with LR . -
pubmed
These studies suggest that
rhIL-6 may have therapeutic value in the treatment of certain
malignancies , especially if used in combination with LR . -
pubmed
Five
tumors were studied with a polymerase chain - reaction assay designed to detect the
E6 region of
human papillomavirus types 16 and 18 . -
pubmed
[ A high level of
alkaline phosphatase in the blood serum is not a contraindication to embolization of the hepatic artery in
malignant neoplasms of the liver ] . -
pubmed
It was inferred that
alkaline phosphatase activity is not indicative of extent of liver involvement by
tumor . -
pubmed
A study was made of the number of pulmonary endocrine cells , immunoreactive for
gastrin - releasing peptide (
bombesin ) or
calcitonin , in the terminal bronchioles of 39 cases of
pulmonary vascular disease . -
pubmed
Serum amylase ,
immunoreactive elastase (
IRE ) ,
carcinoembryonic antigen (
CEA ) , and
carbohydrate antigen (
CA 19 - 9 ) were measured in 40
patients with
pancreatic cancer . -
pubmed
In
pancreatic cancer , elevated values were observed for
amylase in 30 % of the
patients , for
IRE in 70 % , for
CEA in 28 % , and for CA 19 - 9 in 68 % . -
pubmed
Elevated serum
IRE was observed more frequently in
head cancer and resectable
cancer , whereas elevation in CA 19 - 9 occurred more often in body - tail
cancer and unresectable
cancer . -
pubmed
Elevation of serum
IRE tends to occur at earlier stages of
pancreatic cancer . -
pubmed
Renal interaction between sympathetic activity and
ANP in
rats with chronic
ischaemic heart failure . -
pubmed
The diuretic and natriuretic effects of
r - alpha - ANP ( 99 - 126 ) were investigated in
rats with chronic
ischaemic heart failure (
IHF ) produced by left coronary artery ligation . -
pubmed
Immunoglobulin isotypes of anti -
HBc and anti -
HBe and
hepatitis B virus (
HBV ) DNA elimination in
acute hepatitis B. -
pubmed
Antibodies to
hepatitis B core antigen ( anti -
HBc ) and
e antigen (
anti - HBe ) were assayed in 46 sera from ten
patients with
acute hepatitis B utilizing
immunoglobulin class- and subclass - specific enzyme immunoassays ( EIAs ) . -
pubmed
Co - incident N and
K ras gene mutations in a case of
AML , restricted to differing cell lineages . -
pubmed
Peripheral blood from a patient with
acute myeloid leukaemia (
AML ) of M5 FAB classification , was shown to have mutations to both the N and
K ras genes . -
pubmed
The
K - ras mutation , however , was present in all fractions , suggesting it had occurred in a
multi - potential stem cell representing an earlier stage in the generation of the
leukaemia , or possibly an incidental background phenomenon . -
pubmed
Autoantibody from a
patient with
systemic lupus erythematosus was used to label
PCNA in cell suspensions after the cells had been fixed and permeabilized . -
pubmed
Peritonitis incidence and in vitro
bacterial opsonization has been shown to depend on
IgG concentrations in the dialysate and on the ability of macrophages to produce
fibronectin . -
pubmed
In some
CAPD patients a disturbance in
lymphokine and
monokine release may be responsible for the reduced ability of their macrophages to kill bacteria . -
pubmed
With
GVHD directed to
class I H-2 differences , pretreating
LN cells with
anti - Lyt-2 MAb prevented mortality , whereas MAb specific for Ly-1 or
L3T4 cell surface determinants caused severe mortality . -
pubmed
These data imply that lethal
GVHD directed to
class I H-2 differences is mediated by L3T4- , Lyt-2 + cells ; this subset of T cells was shown previously to control
GVHD directed to multiple
minor histocompatibility antigens , i.e. -
pubmed
With whole
H-2 differences ,
GVHD appeared to be controlled largely but not exclusively by L3T4 + , Lyt-2 - T cells . -
pubmed
With class II incompatibilities , depleting donor cells of L3T4 + T cells , either by pretreatment with
anti - L3T4 MAb + C or by fluorescence activated cell sorter selection , greatly reduced but did not completely abolish
GVHD . -
pubmed
The prognostic application of
HL - A and ABO typing in
placental choriocarcinoma . -
pubmed
A common link between the induction of
leukemia by ( i ) fractionated doses of x - irradiation and ( ii ) radiation
leukemia virus in
mice may be established by the observation that the segment of chromosome 2 between the loci for the
minor histocompatibility antigen H-30 and
color coat agouti (
H-30 - A ) includes distinct loci involved in susceptibility to leukemogenesis induced by factors i and ii . -
pubmed
The concept of atypical
depression is reviewed and data comparing the clinical effects of
monoamine oxidase inhibitors and tricyclic antidepressants are presented . -
pubmed
Monoamine oxidase inhibitors are indicated for treatment of syndromes of panic and generalized
anxiety with or without supervening
atypical depression . -
pubmed
We investigated the hemodynamics of the greater and lesser circulation in 35
patients with primary
hypertension , as well as the effects of
calcium - channel blockade , to test whether a common factor may account for the excessive vascular resistance in the two circuits and whether intracellular
calcium concentration ( [
Ca++]i ) may be involved . -
pubmed
Oestrogen receptors and metabolism of
oestrone sulphate in
human mammary carcinoma . -
pubmed
Islet amyloid polypeptide and its N - terminal and C - terminal flanking peptides ' immunoreactivity in islet amyloid of
diabetic patients . -
pubmed
In three non -
diabetic subjects , pancreatic islet cells were immunoreactive to
anti - IAPP8 - 17 and anti - N - terminal and C - terminal flanking peptide antibodies and the reactivity was enhanced with
formic acid pretreatment . -
pubmed
In six
type 2 diabetic subjects and a
subject with
type A insulin resistance , islet amyloid deposits were reactive to
anti - IAPP8 - 17 antibody , but not to anti - N - terminal and C - terminal flanking peptide antibodies . -
pubmed
Osteopontin expression is increased in the heritable
cardiomyopathy of
Syrian hamsters . -
pubmed
BACKGROUND :
Osteopontin , a noncollagenous matrix protein , is transiently expressed in the heart after experimental
cardiac injury , but its expression in states of continuing cardiac remodeling is unknown . -
pubmed
We evaluated
osteopontin expression in the heritable
cardiomyopathy of the
Syrian hamster . -
pubmed
Osteopontin mRNA was 12 - fold greater in
cardiomyopathic hearts compared with normal controls ( 1.76 + /- 0.31 versus 0.14 + /- 0.04 arbitrary units normalized to GAPDH , mean + /- SEM , P & lt ; .05 ) . -
pubmed
Osteopontin mRNA above background levels was not detected in sections from noncardiomyopathic
hamster hearts but was readily detected in sections from
cardiomyopathic hamsters , in which it originated in cells morphologically consistent with tissue macrophages . -
pubmed
CONCLUSIONS : In the
hamster ,
osteopontin is expressed in heritably cardiomyopathic hearts under conditions of
chronic injury and repair , and the source of
ostopontin message appears to be issue macrophage - like cells in foci of
inflammation . -
pubmed
This model could be used to evaluate the biological role of
osteopontin in
myocardial inflammation and remodeling . -
pubmed
Growth stimulation of
ferritin of
human leukemia cells in vitro . -
pubmed
Ferritin has been reported to inhibit the growth of some
leukemia cells in serum - supplemented culture . -
pubmed
Recently we have found that
ferritin stimulates the proliferation of
human acute myeloblastic leukemia cells
HL-60 and erythroleukemia cells
K-562 - T1 in serum - free medium . -
pubmed
In this study , we examined the effect of
ferritin against 14
human leukemia cell lines using
human heart ferritin in serum - depleted culture medium . -
pubmed
These results suggest that
ferritin has dual functions ; it promotes the growth of
leukemia cells with low concentrations of FCS , but suppresses their growth with high concentrations of
FCS . -
pubmed
Antibodies against
CD4 + lymphocytes are frequently detectable in
HIV - infected patients . -
pubmed
The experiments revealed that 60 % of
HIV - infected patients harbored
anti - CD4 cell antibodies in their plasma . -
pubmed
There was a significant reduction in serum
insulin levels and
glucose clearance rates without overt
diabetes for 30 Gy and 35 Gy ( p & lt ; 0.05 ) . -
pubmed
Nucleotide sequences of the central portion of
gp120 , including the third hypervariable ( V3 ) loop , were obtained from lymphocytes cocultivated with
SupT1 cells from 29
AIDS patients in Bangui , Central African Republic . -
pubmed
Glutathione S - transferase in
human esophageal carcinoma . -
pubmed
The expression of
human glutathione S - transferase - pi (
GST - pi ) in
esophageal squamous cell carcinoma and in corresponding morphologically
normal mucosa from 17
patients was examined by Northern blots , in situ hybridization and immunohistochemistry . -
pubmed
Relative
GST - pi expression (
tumor / mucosa ) ranged from 0.31 to 1.52 ( 0.821 + /- 0.40 : mean + /- SD ) , and only 6 out of 17 cases demonstrated increased
GST - pi transcripts in
tumor tissue over
normal tissue . -
pubmed
No significant correlation was observed between the amount or pattern of
GST - pi expression by
carcinomas and the clinicopathological findings in the cases . -
pubmed
The marked expression of
GST - pi by non - pathologic mucosa obtained from the
patients with
esophageal carcinoma suggests that
GST - pi may be a marker of increased carcinogen exposure , but not necessarily a marker of developed
human esophageal cancer . -
pubmed
Increased plasma - soluble
fibrin monomer levels in
patients with
disseminated intravascular coagulation . -
pubmed
Plasma - soluble
fibrin monomer (
SFM ) level in
patients with
disseminated intravascular coagulation ( DIC ) was significantly higher than the level in
patients with pre - DIC or in non - DIC
patients , and the level in
patients with pre - DIC was significantly higher than that in non - DIC
patients . -
pubmed
There was no significant difference in plasma
SFM levels among various diseases underlying
DIC . -
pubmed
Plasma
SFM level in
patients with good outcome was significantly decreased after treatment for
DIC . -
pubmed
Receiver operating characteristic analysis suggests that plasma
SFM level could be the most useful marker for the diagnosis of both
DIC and pre - DIC . -
pubmed
Cellular delivery of
human CNTF prevents motor and
cognitive dysfunction in a
rodent model of
Huntington ' s disease . -
pubmed
The delivery of
ciliary neurotrophic factor (
CNTF ) to the central nervous system has recently been proposed as a potential means of halting or slowing the
neural degeneration associated with
Huntington ' s disease (
HD ) . -
pubmed
The following set of experiments examined , in detail , the ability of
human CNTF (
hCNTF ) to prevent the onset of
behavioral dysfunction in a
rodent model of
HD . -
pubmed
These results support the concepts that implants of polymer - encapsulated
hCNTF - releasing cells can be used to protect striatal neurons from
excitotoxic damage , produce extensive behavioral protection as a result of that neuronal sparing , and that this strategy may ultimately prove relevant for the treatment of
HD . -
pubmed
CONCLUSIONS : In non - metastatic
osteosarcoma of the extremity , chemotherapy - induced
tumor necrosis , the baseline
LDH serum value and the use of
HDMTX are significant predictive factors for DFS . -
pubmed
Hypochromic red cells and
reticulocyte haemglobin content as markers of
iron - deficient erythropoiesis in
patients undergoing chronic haemodialysis . -
pubmed
BACKGROUND : In
patients on chronic haemodialysis , because of a non - specific increase in
serum ferritin ,
iron deficiency may be overlooked leading to failure of
erythropoietin treatment . -
pubmed
Transferrin saturation was also measured in a subset of 25
patients ;
iron deficiency was defined as a
transferrin saturation & lt ; 15 % . -
pubmed
RESULTS : The diagnostic sensitivity and specificity of a reticulocyte
haemoglobin content & lt ; 26 pg in detecting
iron deficiency were 100 % and 73 % respectively , compared with 91 % and 54 % for a percentage of hypochromic red cells & gt ; 2.5 . -
pubmed
CONCLUSIONS : The
reticulocyte haemglobin content is superior to the percentage of hypochromic red cells in detecting
iron deficiency in haemodialysis
patients . -
pubmed
Unusual features of this case of
gliomatosis cerebri include involvement of the entire central neuraxis , correlation with pre - mortem lumbar puncture cytology , and a markedly elevated
Ki-67 labeling index . -
pubmed
The
Brn-3a transcription factor plays a critical role in regulating
human papilloma virus gene expression and determining the growth characteristics of
cervical cancer cells . -
pubmed
Moreover ,
Brn-3a is overexpressed approximately 300 - fold in cervical biopsies from
women with
cervical intra - epithelial neoplasia type 3 (
CIN3 ) compared with normal cervical material . -
pubmed
To test the role of
Brn-3a in
cervical neoplasia we have manipulated its expression in
cervical carcinoma - derived cell lines with or without endogenous HPV genes . -
pubmed
MATERIALS AND METHODS :
Human urothelial cells cultured from
normal bladder specimens underwent immunohistochemical staining and cellular extracts were prepared for Electrophoretic Mobility Shift Assays ( EMSA ) , Western blot analyses , RNA isolation and Northern Blot analyses before and after stimulation with
TNF - alpha , LPS , and dsRNA . -
pubmed
Systemic
hypothermia following
spinal cord compression injury in the
rat : axonal changes studied by
beta - APP ,
ubiquitin , and
PGP 9.5 immunohistochemistry . -
pubmed
OBJECTIVES : The present study addresses the question as to whether systemic
hypothermia has similar protective qualities following severe
spinal cord compression trauma using
beta - APP- ,
ubiquitin- , and
PGP-9.5 - immunohistochemistry combined with the ABC complex method as markers to identify axonal changes . -
pubmed
Hemodynamic abnormalities in the left atrial appendage in
patients with paroxysmal
atrial fibrillation , with special reference to
albumin - contrast echocardiographic aspects . -
pubmed
METHODS AND RESULTS : Transesophageal echocardiography with intravenous
albumin - microspheres (
Albunex , 0.2 ml / kg ) was performed in 100 consecutive
patients ( 44
patients in sinus rhythm without previous paroxysmal
atrial fibrillation : 13
patients in sinus rhythm who had had previous episodes of paroxysmal
atrial fibrillation ; and 43
patients with sustained
atrial fibrillation ) . -
pubmed
Using a refinement of a previously reported cell fusion complementation assay , the previously assigned
Ddb+
xeroderma pigmentosum E strains , XP89TO , XP43TO , and XP24KO , with various phenotypes in DNA repair markers , were reassigned to
xeroderma pigmentosum group F ,
xeroderma pigmentosum variant , and
ultraviolet - sensitive syndrome , respectively . -
pubmed
The
Ddb - xeroderma pigmentosum E strains , XP82TO , and GM02415B , which showed almost normal cellular phenotypes in DNA repair markers , however , remained assigned to
xeroderma pigmentosum group E. With the exception of the Ddb+ strain XP89TO , which demonstrated defective nucleotide excision repair , both
Ddb- and
Ddb+
xeroderma pigmentosum E cells exhibited the same levels of variation in unscheduled DNA synthesis that were seen in normal control cells . -
pubmed
By genome DNA sequencing , the two
Ddb - xeroderma pigmentosum E strains were shown to have mutations in the
DDB2 gene , confirming previous reports for
XP82TO and
GM02415B , and validating the classification of both cells . -
pubmed
As only the Ddb- strains investigated remain classified in the
xeroderma pigmentosum E complementation group , it is feasible that only Ddb- cells are
xeroderma pigmentosum E and that mutations in the
DDB2 gene are solely responsible for the
xeroderma pigmentosum E group . -
pubmed
OBJECTIVE : In the present study , the frequency of
ANT and its associations with
collagen vascular and
spinal disease have been investigated . -
pubmed
Although patients produce antibody exuberantly , the immunopathogenesis involves cellular immunity -- notably ,
CD8(+ ) cytotoxic lymphocytes , multinucleate giant cell
granulomas , and ultimately
interstitial fibrosis . -
pubmed
In typical cases , the history of a known exposure and the presence of a characteristic
interstitial lung disease with serologic confirmation of
IgG antibody to the offending antigen suffice for diagnosis . -
pubmed
In vitro study of
IL-8 and goblet cells : possible role of
IL-8 in the aetiology of
otitis media with
effusion . -
pubmed
These results suggest that : ( i ) goblet cells are target cells for the pro - inflammatory
cytokines IL-1beta ,
TNF - alpha and
IL-8 and can contribute to the pathogenesis of
OME by increasing both the concentration of
IL-8 and the secretion of mucin ; and ( ii )
IL-8 stimulates prolonged
mucin secretion from goblet cells and may be involved in the maintenance of the disease in the chronic stage . -
pubmed
alpha - and beta - secretase : profound changes in
Alzheimer ' s disease . -
pubmed
The
amyloid plaque , a neuropathological hallmark of
Alzheimer ' s disease , is produced by the deposition of
beta - amyloid (
Abeta ) peptide , which is cleaved from
Amyloid Precursor Protein (
APP ) by the enzyme
beta - secretase . -
pubmed
Here , we describe a decrease in
alpha - secretase ( 81 % of normal ) and a large increase in
beta - secretase activity ( 185 % ) in sporadic
Alzheimer ' s disease temporal cortex . -
pubmed
Since
alpha - secretase is present principally in neurons known to be vulnerable in
Alzheimer ' s disease , and there is known competition between alpha- and
beta - secretase for the substrate
APP , it is significant that the majority of
Alzheimer samples tested here were low in
alpha - secretase . -
pubmed
Eighty percent of
Alzheimer brains examined had an increase in
beta - secretase , a decrease in
alpha - secretase , or both ; which may account for the means by which the majority of
people develop
Alzheimer ' s disease . -
pubmed
Blood
glucose monitoring is recommended : to evaluate the glycemic response to the effect of
insulin ; to confirm
hypoglycemia ; to prevent
hyperglycemia in case of disease ; in case of physical exercise . -
pubmed
Flavopiridol , a
cyclin - dependent kinase (
cdk ) inhibitor , can cause cell cycle arrest , induce apoptosis in cancer cells , and inhibit
tumor cell growth in vivo . -
pubmed
The objective of this study was to investigate the use of
folate - targeted liposomes for the delivery of encapsulated
oligonucleotides to
folate receptor (
FR)-positive
tumor cells in vitro and in vivo . -
pubmed
We conclude from these results that
folate liposomes can effectively deliver oligonucleotides into
folate receptor - bearing cells in vitro , but additional barriers exist in vivo that prevent or decrease effective
tumor uptake and retention . -
pubmed
Effects of immunoregulatory
cytokines (
interferon - gamma [
IFN - gamma ] and
interleukin-10 [
IL-10 ] ) and
HSV antigens on
B7 - 1 (
CD80 ) and
B7 - 2 (
CD86 ) expression on monocytes during
HSV-2 infection were investigated using flow cytometry . -
pubmed
Our results demonstrate that
HSV-2 infection effects the expression of
B7 isoforms (
B7 - 1 and
B7 - 2 ) on monocytes in two ways , with opposing outcomes . -
pubmed
Tuberculin - histoplasmin conversion rates in Kansas City as an indication of the prevalence of
infection - preliminary report . -
pubmed
We have shown that in several
chronic inflammatory diseases like
chronic inflammatory bowl disease ,
peritonitis and
rheumatoid arthritis , transsignaling via the soluble
IL-6R complexed to
IL-6 is a crucial point in the transition from the acute to the chronic state of the disease . -
pubmed
Expression of
MMP-2 ,
MMP-7 ,
MMP-9 ,
MMP-10 and
MMP-11 in
human astrocytic and
oligodendroglial gliomas . -
pubmed
The members of the
matrix metalloproteinase family (
MMP ) have the ability to degrade macromolecules of the extracellular matrix and are responsible for
tumor invasion and infiltration , limiting the effectiveness of the neurosurgical resection of
brain tumors . -
pubmed
To determine the pattern of
MMP expression in astrocytic and
oligodendroglial tumors , sections of
astrocytic and oligodendroglial differentiated glioblastomas ( WHO grade IV ) , as well as of
anaplastic oligodendrogliomas ( WHO grade III ) and
anaplastic gemistocytic astrocytomas ( WHO grade III ) were immunostained for
MMP-2 ,
MMP-7 ,
MMP-9 ,
MMP-10 and
MMP-11 . -
pubmed
MMP-7 ,
MMP-10 and
MMP-11 were strongly expressed by neoplastic gemistocytic astrocytes while
oligodendrocytic tumor regions showed only a low immunoreaction . -
pubmed
These data indicated that
MMP-7 ,
MMP-10 and
MMP-11 contribute to the worse prognosis of
astrocytic tumors when compared to
oligodendrogliomas , while
MMP-2 and
MMP-9 might play an important role in neo - angiogenesis and
tumor vascularization . -
pubmed
Because
cytomegaly occurs between 24 and 96 hpi , access to this larger
LIP could be expected to facilitate enlargement to approximately 375 % of the initial cell size . -
pubmed
The ability of
Fe chelation by 100 microM
SIH to limit enlargement to approximately 180 % confirms that the
LIP plays a major role in
cytomegaly . -
pubmed
The serum
HBV - DNA ,
HBeAg / anti -
HBe , hepatic chemistry and the
hepatic fibrosis markers were studied . -
pubmed
CONCLUSION : These results suggested that
lamivudine ( 100mg / d ) could suppress
HBV - DNA replication , promote
ALT normalization , accelerate
HBeAg / anti -
HBe seroconversion , improve the liver pathological changes , slow down the development of
liver fibrosis -
pubmed
Gemtuzumab ozogamicin ( GO ) , an anti -
CD33 monoclonal antibody conjugated to
calicheamicin , is effective as single agent in the treatment of poor risk
acute myeloid leukaemia (
AML )
patients . -
pubmed
The purpose of this study was to compare time- and dose - dependent cellular responses to
Tpt in terms of alterations in the amount and stability of
topo 1 in lung adenocarcinoma (
A-549 ) ,
ovarian adenocarcinoma (
CaOv-3 ) ,
colorectal adenocarcinoma (
HT-29 ) and
breast adenocarcinoma (
MCF-7 ) cell lines . -
pubmed
CONCLUSIONS : Our results suggested that disturbance of the balance of the
AT1 and
AT2 receptors could trigger pregnancy induced
hypertension . -
pubmed
Short - term intensive
insulin therapy in newly diagnosed
type 2 diabetes : response to Ryan , Imes , and Wallace . -
pubmed
Noninvasive detection of
prostate cancer by quantitative analysis of
telomerase activity . -
pubmed
The purpose of this study was to clarify whether quantitative analysis of
telomerase activity in exfoliated cells in urine could serve as a reliable molecular marker of
prostate malignancy . -
pubmed
RESULTS : We report now that all
prostate cancer patients revealed high levels of
telomerase activity thereby showing 100 % of the assay sensitivity . -
pubmed
In contrast , the majority of patients with clinically confirmed
benign prostatic hyperplasia (
BPH ) did not express any
telomerase activity ( 70 % of all
BPH patients ) , most likely presenting
cancer - free cases , or expressed low levels of activity ( 18 % ) . -
pubmed
However , about 12 % of
BPH patients revealed high levels of
telomerase activity that potentially can reflect hidden
prostate cancer . -
pubmed
CONCLUSIONS : We suggest that the quantitative analysis of
telomerase activity can be useful for the selection of
prostate cancer and
cancer - free cases . -
pubmed
Indeed , there is growing evidence that the
gonadotropin ,
luteinizing hormone , which regulates serum
estrogen and
testosterone concentrations , could be an important causative factor in the development of
Alzheimer ' s disease . -
pubmed
This review provides information supporting the "
gonadotropin hypothesis , " puts forth a novel mechanism of how changes in serum luteinizing hormone concentrations could contribute to the pathogenesis of
Alzheimer ' s disease , and discusses potential therapeutic anti - gonadotropin compounds . -
pubmed
In situ gene expression and localization of
metalloproteinases MMP1 ,
MMP2 ,
MMP3 ,
MMP9 , and their inhibitors
TIMP1 and
TIMP2 in
human renal cell carcinoma . -
pubmed
Alterations of
MMP and
TIMP expressions have been found in several
malignant tumour entities . -
pubmed
In this study the expression pattern of
MMP1 ,
MMP2 ,
MMP3 ,
MMP9 , and their inhibitors
TIMP1 , and
TIMP2 were investigated at mRNA and protein levels in
human renal cell carcinoma (
RCC ) . -
pubmed
MMP1 - antigen was strongly expressed in
tumour epithelium with moderate stroma expression in one case . -
pubmed
The
gelatinases MMP2 and
MMP9 showed moderate to strong signals in
tumour epithelial cells at the mRNA and protein level , while the expression in
tumour stroma was moderate . -
pubmed
MMP3 - mRNA and -antigen were expressed moderately to strong in
tumour epithelium and focally in stroma cells . -
pubmed
mRNA or
TIMP1- and
TIMP2 - mRNA and -antigen were also predominantly expressed in
tumour epithelium ; only few samples showed positive expression in stroma cells . -
pubmed
We found a pronounced expression for the
gelatinases MMP2 and
MMP9 and for
MMP3 in
RCC at the mRNA and protein level . -
pubmed
The expression of
TIMP1 and
TIMP2 appears also to be relevant in
RCC . -
pubmed
Neonatal lupus is linked to the presence of anti -
Ro / SS - A and
anti - La / SS - B antibodies in the mother , although other factors probably of fetal origin are important . -
pubmed
Haptoglobin is a positive acute - phase protein with a valuable role as a marker of
inflammation in both
human and veterinary medicine . -
pubmed
No significant differences were produced by anticoagulants ,
lipaemia and
bilirubinaemia , although
haemolysis significantly decreased
haptoglobin . -
pubmed
A significant increase of
haptoglobin concentration was detected in inflammatory conditions such as
pyometra and
leishmaniasis , in neoplastic conditions , and after glucocorticoid administration . -
pubmed
In order to exclude a familiar
PAH , the analysis of the
bone morphogenetic protein receptor 2 gene was carried out , but no mutations were found . -
pubmed
Several findings supported the hypothesis that
Aer has a four - helix HAMP structure : ( i ) cross - linking independently identified the same residues at the dimer interface that were predicted by the model , ( ii ) the rate of cross - linking for residue pairs was inversely proportional to the beta -
carbon distances measured on the model , and ( iii ) clockwise
lesions that were not contiguous in the linear Aer sequence were clustered in one region in the folded HAMP model , defining a potential site of PAS -
HAMP interaction during signaling . -
pubmed
Trp63 mutations are involved in the pathogenesis of several
human diseases , phenotypically characterized by
ectodermal dysplasia . -
pubmed
Periodic acid - Schif staining and immunohistochemical staining of
CD34 were conducted to explore if
VM exists in those Rb specimens . -
pubmed
HIF-1alpha and
VEGF expressions in Rb with
VM were significantly greater than those in Rb without
VM ( P = 0.001 ) . -
pubmed
CONCLUSIONS :
VM exists in
Rb . -
pubmed
Highly differentiated
Rb exhibits more
VM than that in less differentiated
Rb . -
pubmed
Expression of
HIF-1alpha and
VEGF is greater in Rb with
VM , indicating that these factors may stimulate the occurrence of
VM . -
pubmed
CONCLUSIONS : Our study confirmed a close association between preoperative
glucose control indicated by
HbA ( 1c ) levels & lt;7 % and a decreased risk of postoperative
infectious complications . -
pubmed
IFN - gamma - receptor signaling ameliorates
transplant vasculopathy through attenuation of
CD8 + T - cell - mediated injury of vascular endothelial cells . -
pubmed
However ,
MCMV - LacZ
infection of recipients of
ifngr(-/- )
Tie2 - LacZ hearts led to massive activation of beta - gal - specific CD8 T cells , and led to development of fulminant
TV . -
pubmed
Further analyses revealed that the strong systemic
IFN - gamma " storm " associated with
MCMV infection induced upregulation of
programmed death-1 ligand 1 (
PD - L1 ) on EC , and subsequent attenuation of
programmed death-1 (
PD-1)-expressing EC - specific
CD8(+ ) T cells . -
pubmed
Thus ,
IFNGR signaling in ECs activates a potent peripheral negative feedback circuit that protects vascularized grafts from occlusive
TV . -
pubmed
These
patients were predominantly male ( 92.9 % vs 80.3 % , P & lt ; 0.001 ) , more likely to smoke ( 75.8 % vs 47.2 % , P & lt ; 0.001 ) ,
obese ( 48.2 % vs 27.9 % , P = 0.002 ) , have higher
triglyceride levels ( 176.9 + /- 153.8 mg / dL vs 140.7 + /- 112.7 mg / dL , P = 0.005 ) , and lower
high - density lipoprotein cholesterol ( 37.1 + /- 7.9 mg / dL vs 42.8 + /- 14.3 mg / dL , P = 0.005 ) than older
patients . -
pubmed
The recombinant outer membrane protein
OprF / I has been demonstrated in previous studies to protect against
Pseudomonas aeruginosa infection through a mechanism of enhanced antibody - mediated opsonophagocytosis . -
pubmed
aeruginosa binding to
IFN - gamma , suggesting an alternative mechanism by which the
OprF / I vaccine confers protection against
P. - pubmed
Multiple regression analysis revealed that the factors contributing to the elevation of ABR threshold were
congenital diaphragmatic hernia , severe
respiratory disease , and a high
C - reactive protein (
CRP ) level . -
pubmed
Factors significantly related to an elevation of ABR threshold were a history of
congenital diaphragmatic hernia , severe
respiratory disease , and elevation of
CRP . -
pubmed
We present a case of metastatic
CDC that responded favorably to a multiple
tyrosine kinase inhibitor ,
sunitinib , achieving a partial response in both lung and skeletal metastases . -
pubmed
Considering these findings , it would be worthwhile prospectively investigating the role of multiple
tyrosine kinase inhibitors , particularly
sunitinib , in the management of metastatic
CDC . -
pubmed
[ The expression of
CEACAM-1 and
CXCL-14 in
infantile hemangioma ] . -
pubmed
OBJECTIVE : To examine the expression of
CEACAM - land CXCL-14 in the different stages of
infantile hemangioma and to explore the role of
CEACAM-1 and
CXCL-14 in the occurrence and development of
infantile hemangioma . -
pubmed
METHODS : The expression of
CEACAM-1 and
CXCL-14 was detected by immunohistochemical technique and Western Blot in cases of proliferating
hemangiomas , involuting
hemangiomas , involuted
hemangiomas . -
pubmed
RESULTS : The expression of
CEACAM-1 in early stage of proliferating
hemangiomas was weak or negative , while it was strong in involuting
hemangiomas and positive in the involuted stage . -
pubmed
The expression of
CXCL-14 was weak or negative in stage of proliferating
hemangiomas , positive in involuting
hemangiomas and strong in the involuted stage . -
pubmed
CONCLUSIONS :
CEACAM-1 and
CXCL-14 are involved in the occurrence and development of
infantile hemangioma . -
pubmed
We planned this case - control study to evaluate the relationship between
hypogonadism , as defined by the sexual hormone profile (
FSH ,
LH ,
testosterone ( T ) and
prolactin ) and ED , as assessed by means of an internationally validated self - administered questionnaire ( IIEF ) . -
pubmed
DM1 patients had significantly increased mean levels of both
gonadotropins (
FSH and
LH ) ( p < 0.0001 ) and a reduced mean level of T ( p < 0.0001 ) when compared to controls . -
pubmed
Twelve
patients were eugonadic ( normal
LH , T , and
FSH ) , while 18 displayed hormonal evidence of
hypogonadism , characterized by
tubular failure ( increased
FSH ) in all the subjects and associated with
interstitial failure in 14
subjects : seven with
primary hypogonadism ( increased
LH and
reduced T ) and seven with compensated
hypogonadism ( increased
LH and normal T ) . -
pubmed
In general ,
patients with recent onset
RA have earlier clinical improvement when treated with initial combination therapy with
prednisone or a
tumor necrosis factor inhibitor than when treated with initial monotherapy . -
pubmed
Rac1 is necessary for their transition from G1 to S phase , at least in part by regulating
cyclin D levels and
retinoblastoma protein phosphorylation . -
pubmed
Purine /
Pyrimidine nucleotides ratio ( OD 260 : OD 280 ) was also measured RESULTS :
P5'N-1 deficient patients showed reduction in
P5'N-1 activity ( Mean + - SD ; 4.06 + - 0.66 using an ELISA reader & amp ; 6.25 + - 1.37 using a spectrophotometer ) as compared to the normal control group ( ELISA reader : 13.24 + - 3.42 & amp ; Spectrophotometer : 18.25 + - 3.20 ) . -
pubmed
[ Generation of antitumor response against
hepatocellular carcinoma by in vitro transduction of dendritic cells with adeno - associated virus expressing
alpha - fetoprotein ] . -
pubmed
OBJECTIVE : To investigate the generation of antitumor response against
hepatocellular carcinoma by in vitro transduction of dendritic cells ( DC ) with recombinant adeno - associated virus expressing
alpha - fetoprotein (
rAAV - AFP ) . -
pubmed
19.84 % of
CD4(+)T cells and 18.65 % of
CD8(+)T cells activated by AAV -
AFP + DC produced
IFN - gamma but not
IL-4 and showed distinct killing activities against AFP positive
hepatocellular carcinoma cell lines
HepG2 ( 56.45 % ) and
BEL7402 ( 78.84 % ) . -
pubmed
CONCLUSION : AAV - AFP + DC can elicit distinct antitumor responses against AFP positive
hepatocellular carcinoma cell lines so as to provide a basis for further researches on the clinical application of AAV -
AFP + DC in the treatment of
hepatocellular carcinoma . -
pubmed
Anaemia during pregnancy : impact on birth outcome and infant
haemoglobin level during the first 18 months of life . -
pubmed
To determine the effect of
maternal anaemia on pregnancy outcome and describe its impact on infant
haemoglobin level in the first 18 months of life , we conducted a prospective study of 617 pregnant women and their children in Benin . -
pubmed
There was no association between an infant 's
haemoglobin level until 18 months and maternal
anaemia . -
pubmed
However ,
malaria attacks during follow - up , male gender and sickle cell trait were all associated with a lower infant
haemoglobin level until 18 months , whereas good infant feeding practices and a polygamous family were positively associated with a higher
haemoglobin level during the first 18 months of life . -
pubmed
Analysis of serum total
IgE , specific
IgE and eosinophils in
children with acute and chronic
urticaria . -
pubmed
BACKGROUND / PURPOSE : Increased
IgE and eosinophil levels are frequently observed in
cutaneous inflammation and are thought to provoke the occurrence of
urticaria . -
pubmed
The aim of this study was to compare serum total
IgE levels , specific
IgE sensitization rates and eosinophil percentages between acute and chronic
urticaria in
children . -
pubmed
Serum levels of total
IgE , prevalence of sensitization to food and aeroallergens and blood eosinophil percentages were compared by the disease duration of
urticaria . -
pubmed
RESULTS : There were no statistical differences in total
IgE production , positive sensitization to specific allergens and eosinophil percentages between the
patients with acute and chronic
urticaria . -
pubmed
CONCLUSION :
Boys potentially have a higher serum
IgE expression than girls
children with
urticaria . -
pubmed
IgE levels and eosinophil percentages are not good indicators for a prolonged course of
urticaria . -
pubmed
Plasma fatty acid - binding protein 4 ,
nonesterified fatty acids , and incident
diabetes in older
adults . -
pubmed
OBJECTIVE : To examine the relation of
fatty acid - binding protein ( FABP ) 4 and
nonesterified fatty acids (
NEFAs ) to
diabetes in older
adults . -
pubmed
For each SD increase in log
FABP4 , hazard ratios ( HRs ) for
diabetes were 1.35 ( 95 % CI 1.10 - 1.65 ) for women and 1.45 ( 1.13 - 1.85 ) for men controlling for age , race , education , physical activity , cystatin C ,
alcohol intake , smoking , self - reported health status , and
estrogen use for women ( P for sex -
FABP4 interaction 0.10 ) . -
pubmed
BMI modified the
FABP4 -
diabetes relation ( P = 0.009 overall ; 0.02 for women and 0.135 for men ) , in that statistically significant higher risk of
diabetes was mainly seen in men with BMI & lt;25 kg / m(2 ) ( HR per SD : 1.78 [ 95 % CI 1.13 - 2.81 ] ) . -
pubmed
CONCLUSIONS : Plasma
FABP4 was positively associated with incident
diabetes in older adults , and such association was statistically significant in lean men only . -
pubmed
All 19
neoplasms were positive for
thyroid transcription factor 1 and
thyroglobulin but negative for
parathyroid hormone and
calcitonin . -
pubmed
Following the consumption of contaminated food or water by a
human host , the
Vibrio cholerae bacterium produces virulence factors , including
cholera toxin (
CT ) , which directly causes
voluminous diarrhea , producing
cholera . -
pubmed
CD8 + T - cell activation in
HIV-1 - infected patients experiencing transient low - level
viremia during antiretroviral therapy . -
pubmed
We found that TLLV does not significantly change
CD8 T - cell activation and that higher
CD8 T - cell activation during viral suppression & lt;50 copies per milliliter is associated with a modest increase in the risk of a subsequent
TLLV . -
pubmed
Intra - acinar cell activation of digestion enzymes triggers the events of acute
pancreatitis and stimulates the production of
inflammatory cytokines . -
pubmed
Finally , inflammatory
cytokines trigger inflammatory cascades that lead to
systemic inflammatory response syndrome ,
multi - organ failure , or death . -
pubmed
However , a possible correlation between RBC
MTX and
MTXGlu2 - 5 concentrations and clinical outcomes of
MTX treatment in
RA is debated . -
pubmed
Main changes of blood biochemical included
hypokalemia ,
lactic acidosis ,
hyperglycemia ,
hypsocreatinkinase . -
pubmed
Median overall survival for
mucin positive and
mucin negative tumors was 4(1.3 - 5.7 ) and 3.3(0.1 - 6.3 ) years respectively . -
pubmed
Expected 5 year
disease free and overall survival for
mucin positive and
mucin negative tumors was 73 % and 89 % ( P = 0.1 ) and 75 % and 87 % ( P = 0.4 ) . -
pubmed
CONCLUSION : Acellular
mucin pools in
rectal cancer following a PCR to neoadjuvant treatment do not impact survival . -
pubmed
RESULTS : Compared with men ( n = 765 ) ,
women ( n = 274 ) were older ( p & lt ; 0.001 ) and more likely to have
hypertension ( p & lt ; 0.001 ) ,
diabetes ( p = 0.002 ) , and higher
low - density lipoprotein cholesterol (
LDL - C ) ( p = 0.01 ) ,
high - density lipoprotein cholesterol ( p & lt ; 0.001 ) , and
C - reactive protein (
CRP ) ( p = 0.004 ) levels . -
pubmed
Greater PAV regression in women versus men occurred with
rosuvastatin ( p = 0.004 ) , those with
diabetes ( p = 0.01 ) , stable
coronary disease ( p = 0.01 ) , higher baseline
LDL - C ( p = 0.02 ) , and higher
CRP ( p = 0.04 ) levels . -
pubmed
Annexin A5 promotes invasion and chemoresistance to
temozolomide in
glioblastoma multiforme cells . -
pubmed
Annexin A5 reportedly promotes progression and chemoresistance in a variety of
cancers . -
pubmed
In the present study , we explored the effects of
annexin A5 on
GBM cell invasion and chemoresistance to
temozolomide . -
pubmed
Stable overexpression and knockdown of
annexin A5 were performed in both
U-87 MG and
U-118 MG human GBM cell lines . -
pubmed
In conclusion , our study provides the first evidence that
annexin A5 promotes
GBM cell invasion ,
MMP-2 expression / activity , and chemoresistance to
temozolomide through a
PI3K - dependent mechanism . -
pubmed
It adds new insights not only into the biological function of
annexin A5 but also into the molecular mechanisms underlying
GBM progression and chemoresistance . -
pubmed
AIM : The treatment strategy for
steroid - resistant
nephrotic syndrome remains uncertain at present , especially in those with
calcineurin inhibitor resistance or intolerance . -
pubmed
To date , few studies have been published using multiple combination therapy of immunosuppressive reagents for
children with
calcineurin inhibitor - resistant or -intolerant
nephrotic syndrome . -
pubmed
Biochemical parameters included the following : ( a ) indices of CLGI ( high - sensitivity
C - reactive protein , erythrocyte sedimentation rate and
fibrinogen ) ; ( b )
insulin resistance ( Homeostasis Model Assessment of
Insulin Resistance index ) ; ( c ) adiposity ( plasma
adiponectin ) . -
pubmed
Additionally , 3.8 % of the
rifampin - resistant isolates showing no mutation in the
rpoB gene were significantly associated with mixed
infections ( chi(2 ) , 56.78 ; P & lt ; 0.01 ) . -
pubmed
This study revealed for the first time that Manu2 was the predominant group in the cases of mixed
infections , and this might be the main reason for heteroresistance and a possible mechanism for isolates without any mutation in the
rpoB gene to become
rifampin resistant . -
pubmed
Relationship of endothelial area with
VEGF - A ,
COX-2 ,
maspin ,
c - KIT , and
DOG-1 immunoreactivity in
liposarcomas versus
non - lipomatous soft tissue tumors . -
pubmed
Although
DOG-1 is considered a specific marker for gastrointestinal
tumors (
GISTs ) , its positivity , correlated with
c - KIT and
VEGF immunoexpression , was also shown by
dermatofibrosarcomas and
tumors with histiocytic and lipomatous differentiation , suggesting its possible pro - angiogenic role . -
pubmed
Maspin expression was observed in adipose tissue
tumors only . -
pubmed
Regarding angiogenesis , 31 of the 55 cases were
VEGF - positive , such positivity being directly correlated with
COX-2 and
CD34 positivity as evaluated in the
tumor cells and also with
MVD . -
pubmed
Based on these aspects , we conclude that
VEGF /
COX-2 - induced angiogenesis is specific for
non - lipomatous tumors , whereas
liposarcomas are dependent on the
VEGF /
maspin angiogenic pathway . -
pubmed
The
DOG-1 /
c - KIT /
VEGF target may be used for further personalized therapy of
soft tissue sarcomas . -
pubmed
No data about
DOG-1 and
maspin positivity in
liposarcomas have been published to date . -
pubmed
The presence of a strong connection between reported
COX-2 inhibitors and
cardiac toxicity encourages medicinal chemists to explore new scaffolds . -
pubmed
Starting from our lead compound 5a , structure - based drug - design was conducted and more potent analogues were obtained with high
COX-2 selectivity and almost full
edema protection , in carrageenan - induced
edema assay , in case of compound 5e . -
pubmed
No other demographic or clinical factors , such as
cardiac disease ,
diabetes mellitus , smoking , lipid status ,
serum fibrinogen , hematocrit , antiphospholipid antibody titer , or ultrasound results of the carotid arteries entered the model . -
pubmed
PURPOSE : The fully
human monoclonal antibody nivolumab binds to the
programmed death-1 ( PD-1 ) receptor , blocking interactions between
PD-1 and its ligands on tumor cells and preventing T cell exhaustion in
patients with
cancer . -
pubmed
In recent years ,
gefitinib , an
epidermal growth factor receptor tyrosine kinase inhibitor , has shown its good antitumor activities in treating
NSCLC in a number of studies . -
pubmed
In this study , we identified a novel lncRNA ,
GClnc1 , which was upregulated and associated with tumorigenesis ,
tumor size , metastasis , and poor prognosis in
gastric cancer . -
pubmed
GClnc1 affected
gastric cancer cell proliferation , invasiveness , and metastasis in multiple
gastric cancer models . -
pubmed
Mechanistically ,
GClnc1 bound
WDR5 ( a key component of
histone methyltransferase complex ) and
KAT2A histone acetyltransferase , acted as a modular scaffold of
WDR5 and
KAT2A complexes , coordinated their localization , specified the
histone modification pattern on the target genes , including
SOD2 , and consequently altered
gastric cancer cell biology . -
pubmed
Thus ,
GClnc1 is mechanistically , functionally , and clinically oncogenic in
gastric cancer . -
pubmed
Targeting
GClnc1 and its pathway may be meaningful for treating
patients with
gastric cancer . -
pubmed
This study reveals that
GClnc1 is an oncogenic lncRNA in
human gastric cancer . -
pubmed
High throughput chemical library screening identifies a novel
p110 - delta inhibitor that potentiates the anti -
myeloma effect of
bortezomib . -
pubmed
The
phosphatidyl - inositol-3 - kinase (
PI3 K ) pathway is constitutively hyperactivated in
MM to promote disease progression and drug resistance . -
pubmed
While inhibiting
PI3 K induces apoptosis in
MM and is predicted to increase
tumor susceptibility to anticancer therapy , early - generation pan -
PI3 K inhibitors display poor clinical efficacy as well as intolerable side effects . -
pubmed
Here , we found that
PI3 K activity is significantly upregulated in
MM cell lines and
patient tumor cells resistant to
bortezomib and that the majority of
PI3 K activity in
MM cells is dependent upon the
p110 - delta isoform . -
pubmed
Genetic or pharmacologic inhibition of
p110 - delta substantially reduced
myeloma viability and enhanced cellular sensitivity to
bortezomib . -
pubmed
Taken together , the results provide the basis for further clinical evaluation of
p110 - delta inhibitors , as monotherapy or in synergistic combinations , for the benefit of
MM patients . -
pubmed
The
Arabidopsis thaliana T - DNA insertion mutant glucose hypersensitive ( ghs ) 40 - 1 exhibited
hypersensitivity to
glucose (
Glc ) and
abscisic acid (
ABA ) . -
pubmed
Lung injury was accompanied by the upregulation of
PLTP and
IL-8 in the CSE - exposed
rat model , and the number of white blood cells in the BALF was significantly increased compared with those of the controls . -
pubmed
Topoisomerase 1 (
TOP1 ) poisons like
camptothecin (
CPT ) are currently used in
cancer chemotherapy but these compounds can have damaging , off - target effects on neurons leading to
cognitive , sensory and motor deficits . -
pubmed
Genomic pathways modulated by
Twist in
breast cancer . -
pubmed
There is evidence to indicate that
Twist expression plays a role in breast
tumor formation and metastasis , but the role of
Twist in dysregulating pathways that drive the metastatic cascade is unclear . -
pubmed
Moreover , many of the genes and pathways dysregulated by
Twist in cell lines and
mouse models have not been validated against data obtained from larger , independant datasets of
breast cancer patients . -
pubmed
METHODS : We over - expressed the
human Twist gene in non - metastatic
MCF-7 breast cancer cells to generate the
estrogen - independent metastatic
breast cancer cell line
MCF-7 /
Twist . -
pubmed
Microarray data was collected from both in vitro (
MCF-7 and
MCF-7 / Twist cell lines ) and in vivo ( primary
tumors and lung metastases ) models of
Twist expression . -
pubmed
RESULTS : Our data establishes a
Twist over - expressing
mouse model of
breast cancer , which
metastasizes to the lung and replicates some of the ontogeny of
human breast cancer progression . -
pubmed
CONCLUSIONS : Analogous gene expression patterns were observed in both in vitro and in vivo
Twist preclinical models of
breast cancer metastasis and
breast cancer patient datasets supporting the functional role of
Twist in promoting
breast cancer metastasis . -
pubmed
The data suggests that genetic dysregulation of
Twist at the cellular level drives alterations in gene pathways in the
Twist metastatic
mouse model which are comparable to changes seen in
human breast cancers . -
pubmed
In ~50 % of
prostate cancers , chromosomal rearrangements cause the fusion of the promoter and 5'-UTR of the
androgen - regulated
TMPRSS2 ( transmembrane protease ,
serine 2 ) gene to the open reading frame of
ERG , encoding an ETS family transcription factor . -
pubmed
ERG is not expressed in
normal prostate epithelia , but when expressed , it promotes tumorigenesis via altered gene expression , stimulating epithelial - mesenchymal transition , cellular migration / invasion , and transformation . -
pubmed
In conclusion , our findings have identified critical molecular mechanisms involving
ERK - mediated
ERG activation that could be exploited for therapeutic intervention in
ERG - positive
prostate cancers . -
pubmed
Glycobiology of
syndecan-1 in
bacterial infections . -
pubmed
Loss of
Sdc1 in
mice is a gain - of - function mutation that significantly decreases the susceptibility to several
bacterial infections , suggesting that subversion of
Sdc1 is an important virulence strategy . -
pubmed
Here , we discuss several examples of
Sdc1 subversion in
bacterial infections . -
pubmed
Synergistic antiproliferative effects of an
mTOR inhibitor (
rad001 ) plus
gemcitabine on
cholangiocarcinoma by decreasing
choline kinase activity . -
pubmed
This study aims to investigate a novel therapeutic regimen [
gemcitabine plus
everolimus (
rad001 ) , an
mTOR inhibitor ] for
cholangiocarcinoma . -
pubmed
In the in vitro study ,
gemcitabine plus
rad001 exerted a synergistic therapeutic effect on the
cholangiocarcinoma cells , irrespective of the
KRAS mutation status . -
pubmed
In the xenograft study ,
gemcitabine plus
rad001 showed the best therapeutic effect on
tumor volume change , and was associated with increased
caspase-3 expression , decreased
eIF4E expression , as well as overexpression of both
death receptor- and mitochondrial apoptotic pathway - related genes . -
pubmed
We concluded that
gemcitabine plus
rad001 has a synergistic antiproliferative effect on
cholangiocarcinoma , irrespective of the
KRAS mutation status . -
pubmed
PURPOSE OF REVIEW : Defining predisposition to
allergic drug reactions has largely focussed on
HLA associations , but other genetic and nongenetic factors are also likely to be involved . -
pubmed
RECENT FINDINGS : Polymorphic genetic variants in cytokine genes , including
IL-10 , and co - signalling pathways , including
CTLA4 , have been associated with
allergic drug reactions , but the effect size is lower than with
HLA alleles and most associations have not been replicated . -
pubmed
Although
TCR specificity seems to be important for
CBZ - induced
SJS /
TEN in South East Asian patients , a distinct repertoire may not play a role in reactions to other drugs . -
pubmed
Histamine dysregulation has been identified as a rare genetic cause of
tic disorders ;
mice with a knockout of the
histidine decarboxylase (
Hdc ) gene represent a promising model of this pathophysiology . -
pubmed
The
H3R histamine receptor is elevated in the striatum of
Hdc KO
mice , and
H3R agonists , acting in the dorsal striatum , trigger
tic - like movements in the model . -
pubmed
Mutations in the
collagen genes
COL4A1 and
COL4A2 cause
Mendelian eye , kidney and cerebrovascular disease including
intracerebral haemorrhage (
ICH ) , and common
collagen IV variants are a risk factor for
sporadic ICH . -
pubmed
COL4A1 and
COL4A2 mutations cause endoplasmic reticulum ( ER ) stress and basement membrane ( BM ) defects , and recent data suggest an association of
ER stress with
ICH due to a
COL4A2 mutation . -
pubmed
We performed a preventative oral treatment of
Col4a1 mutant
mice with the chemical chaperone
phenyl butyric acid (
PBA ) , which reduced adult
ICH . -
pubmed
However ,
PBA treatment did not alter
eye and kidney defects , establishing tissue - specific outcomes of targeting
Col4a1 - derived ER stress , and therefore this treatment may not be applicable for
patients with
eye and renal disease . -
pubmed
Alleviating ER stress is a valid therapeutic target for preventing and treating established adult
ICH , but
collagen IV patients will require stratification based on their clinical presentation and mechanism of their mutations . -
pubmed
Furthermore , to evaluate the molecular mechanism involved in
cancer cell death , we studied the genes that are involved in
fatty acid and
cholesterol biosynthesis pathway including
3 - hydroxy-3 - methylglutaryl - coenzyme A reductase (
HMGCR ) ,
Acetyl CoA synthase (
ACC ) ,
sterol regulatory element - binding protein (
SPREPB1 ) and
fatty acid synthase (
FASN ) respectively . -
pubmed
HMGB1 gene polymorphism is associated with
coronary artery lesions and intravenous
immunoglobulin resistance in
Kawasaki disease . -
pubmed
Recent reports of elevated serum
high mobility group box 1 (
HMGB1 ) level during the acute phase of
KD and its relationship to poor response to IVIG treatment suggest a possible association of
HMGB1 polymorphisms with
KD . -
pubmed
We investigated the association between the polymorphisms of the
HMGB1 gene ,
KD susceptibility ,
coronary artery lesions , and
KD response to IVIG treatment . -
pubmed
RESULTS : The
HMGB1 single nucleotide polymorphisms were not associated with
KD susceptibility . -
pubmed
CONCLUSION : The rs1412125 in
HMGB1 might be a risk factor for the development of
coronary artery lesions and IVIG resistance in
KD patients . -
pubmed
Additionally , we provided evidence that DNMTs control the global hypomethylation of oncogenes , including
ALOX5AP and
CSF3R that otherwise have high methylation in
normal colons . -
pubmed
Such genes were also more sensitive to
DNMT changes , such as in
CRC . -
pubmed
Two comparative assessments of intravenous
immunoglobulin therapy switching patterns in the treatment of
chronic inflammatory demyelinating polyneuropathy in the US . -
pubmed
Tapentadol is a novel analgesic molecule that synergistically combines two mechanisms of action ,
micro - opioid receptor agonism and
norepinephrine reuptake inhibition , and for which multiple literature data are available that confirm its efficacy and safety in controlling
pain . -
pubmed
Computational screening of phytochemicals against
survivin protein : A potent target for
cancer . -
pubmed
RESULTS :
EOCs were heterogeneous , frequently harboring
KRAS ,
PIK3CA ,
PTEN ,
CTNNB1 ,
ARID1A and
TP53 mutations . -
pubmed
EOCs were distinct from
HGSOCs at the mutational level , less frequently harboring
TP53 but more frequently displaying
KRAS ,
PIK3CA ,
PIK3R1 ,
PTEN and
CTNNB1 mutations . -
pubmed
Compared to synchronous
EOCs and pure
EECs , pure
EOCs less frequently harbored
PTEN ,
PIK3R1 and
ARID1A mutations . -
pubmed
Akin to
EECs ,
EOCs could be stratified into the four molecular subtypes : 3 %
POLE ( ultramutated ) , 19 %
MSI ( hypermutated ) , 17 %
copy - number high ( serous - like ) and 61 %
copy - number low (
endometrioid ) . -
pubmed
In addition to microsatellite instability , a subset of
EOCs harbored potentially targetable mutations , including
AKT1 and
ERBB2 hotspot mutations . -
pubmed
AIMS : To examine whether the presence of two common missense variants in the
CYP2C9 gene ( rs1799853 , encoding Arg144Cys and denoted as * 2 , and rs1057910 , encoding Ile359Leu and denoted as * 3 ) influences the acute physiological response to a single
glipizide dose in
individuals naive to
diabetes medications . -
pubmed
CONCLUSIONS : Carriers of two reduced function alleles in
CYP2C9 may experience an increased
insulin response to
glipizide and be predisposed to a higher risk of
hypoglycaemia , although no effect of genotype was seen in
glucose - based measurements . -
pubmed
Material and methods : In the Maria Sklodowska - Curie Institute - Oncology Centre , between 2011 and 2017 , 318 non - resectable or metastatic
melanoma patients were treated with immune checkpoint inhibitors : anti -
CTLA-4 or / and anti -
PD-1 . -
pubmed
Among this group 10 % of
patients had
brain metastases , 24 % of
patients had
BRAF mutant
melanoma , and co - morbidities were present in 86 % of
patients ( mainly
hypertension ,
cardiovascular diseases and/or
diabetes ) . -
pubmed
This integrative analysis revealed that
tumors with high stromal clustering and barrier had reduced expression of pathways involved in naive
CD4 signalling ,
MAPK and
PI3 K signalling . -
pubmed
Endothelin-1 (
ET-1 ) , an endogenous vasoactive peptide , has been found to play an important role in peripheral
pain signaling . -
pubmed
Acid - sensing ion channels (
ASICs ) are key sensors for extracellular protons and contribute to
pain caused by
tissue acidosis . -
pubmed
Finally , we showed that pharmacological blockade of
ASICs by
amiloride or
APETx2 significantly alleviated
ET-1 - induced flinching and mechanical
hyperalgesia in
rats . -
pubmed
Tooth extractions in
patients under antiresorptive therapy for
osteoporosis : Primary closure of the extraction socket with a mucoperiosteal flap versus application of platelet - rich
fibrin for the prevention of antiresorptive agent - related
osteonecrosis of the jaw . -
pubmed
PURPOSE : The aim of this study was to compare primary closure of the extraction socket to application of
platelet - rich fibrin ( PRF ) without subsequent primary closure for the prevention of
osteonecrosis of the jaw (
ONJ ) in
patients administered antiresorptive therapy for
osteoporosis . -
pubmed
RECOMMENDATIONS : In the adjuvant setting , nivolumab or pembrolizumab should be offered to
patients with resected stage IIIA / B / C / D
BRAF wild - type
cutaneous melanoma , while either of those two agents or the combination of
dabrafenib and
trametinib should be offered in
BRAF - mutant disease . -
pubmed
In the unresectable / metastatic setting , ipilimumab plus nivolumab , nivolumab alone , or pembrolizumab alone should be offered to
patients with
BRAF wild - type
cutaneous melanoma , while those three regimens or combination
BRAF /
MEK inhibitor therapy with
dabrafenib /
trametinib ,
encorafenib /
binimetinib , or
vemurafenib /
cobimetinib should be offered in
BRAF - mutant disease . -
pubmed
lncRNA -
PRLB Confers
Paclitaxel Resistance of
Ovarian Cancer Cells by Regulating
RSF1 /
NF - kappaB Signaling Pathway . -
pubmed
Background : The long noncoding RNA ( lncRNA)-
PRLB ( progression - associated lncRNA in
breast cancer ) has been identified to enhance the drug resistance of
breast cancer cells . -
pubmed
In this study , the authors explored
PRLB effect in the
paclitaxel (
Tax ) resistance of
ovarian cancer cells and revealed the role of
RSF1 (
remodeling and spacing factor 1)/
nuclear factor kappaB (
NF - kappaB ) signaling in this process . -
pubmed
The expressions of
PRLB in
Tax resistant tissues and cells of
ovarian cancer were detected using the real time polymerase chain reaction assay . -
pubmed
Results :
PRLB expression was obviously enhanced in the
Tax resistant
ovarian cancer tissues and cells . -
pubmed
Conclusion : This study reveals that knockdown of
PRLB improves the sensitivity of
ovarian cancer cells to
Tax , at least in part , through inhibiting the activation of
RSF1 /
NF - kappaB signaling through targeting miR-150 - 5p . -
pubmed
While IMCL content scales negatively with
insulin resistance , athletes are highly
insulin sensitive in contrast to
T2D patients , the so - called athlete 's paradox . -
pubmed
Thus , we developed a novel fluorescent super - resolution microscopy approach and found that
PLIN2 protein abundance at the LD surface was higher in
T2D patients than in athletes . -
pubmed
While
PLIN5 abundance at the LD surface was similar in athletes and
T2D patients , we have observed previously that the number of
PLIN5 decorated LDs was higher in athletes , indicating more LDs in close association with mitochondria . -
pubmed
Anti -
cN1A antibodies do not correlate with specific clinical , EMG or pathological findings in
sporadic inclusion body myositis . -
pubmed
INTRODUCTION : Anti - cytosolic
5 '- nucleotidase 1A (
cN1A ) antibodies are commonly detected in
patients with
sIBM . -
pubmed
RESULTS : Anti -
cN1A antibodies were present in 47/92 ( 51 % )
patients with
sIBM . -
pubmed
The antibody titer did not correlate with the clinical phenotype ,
CK value or presence of
myotonic discharges on EMG . -
pubmed
Anti -
cN1A antibody positive
patients appeared to have more frequent auto - aggressive
inflammation on muscle biopsy but not as an isolated myopathological feature . -
pubmed
DISCUSSION : Our study showed that anti -
cN1A antibody positive and negative
sIBM patients have similar clinical features and disease severity . -
pubmed
Anti -
cN1A antibodies in our
sIBM cohort did not correlate with any studied clinical or laboratory parameter and , therefore , were of limited value in the
patient 's assessment . -
pubmed
5 - Hydroxy-4 - methoxycanthin-6 - one alleviates dextran sodium sulfate - induced
colitis in
rats via regulation of metabolic profiling and suppression of
NF - kappaB /
p65 signaling pathway . -
pubmed
A UPLC - Q - TOF - MS / MS approach - based metabolomics analysis was conducted to explore the underlying mechanisms of
PQ - A in
colitis treatment . -
pubmed
CONCLUSIONS : We provide an overview of
PQ - A 's possible mechanism of action in
colitis treatment based on serum non - targeted metabolomics . -
pubmed
PQ - A treatment can protect
rats against DSS - induced
colitis by suppressing the
NF - kappaB /
p65 signaling pathway . -
pubmed
Patients with critical disease had significantly lower levels of
anti - HCoV OC43 - NP ( p = 0.016 ) and
HCoV HKU1 - NP ( p = 0.023 ) antibodies at the first encounter compared to other
COVID-19 patients . -
pubmed
Endothelin-1 caused a significant decrease in UF , UNaV and UKV only at a later period , despite a relatively early
depression of renal haemodynamics . -
pubmed
In this study we compared 2 putative biochemical markers for rejection of pancreas allografts , serum immunoreactive anodal
trypsinogen and urinary
amylase , with serum
creatinine in 15 simultaneously transplanted
type I diabetics . -
pubmed
ISDN and its two main hepatic metabolites ,
isosorbide-2 - mononitrate (
IS-2 - MN ) and
isosorbide-5 - mononitrate (
IS-5 - MN ) were compared for their ability to inhibit
platelet aggregation and
thromboxane B2 generation in vitro in response to threshold concentrations of
ADP ,
adrenaline ,
collagen ,
thrombin and
arachidonic acid . -
pubmed
Characterization of
mammalian type IX collagen fragments from limited
pepsin digests of a transplantable swarm
rat chondrosarcoma . -
pubmed
Collagenous fragments from type IX molecules have been solubilized by limited
pepsin proteolysis of a transplantable
rat chondrosarcoma and isolated by selective salt precipitation . -
pubmed
streptokinase ( SK ) in the treatment of
acute myocardial infarction (
AMI ) in two cardiac care units . -
pubmed
The time interval from the beginning of acute symptoms to the arrival at the hospital was 2.8 + /- 1.2 hours ( 1 to 15 ) and from that moment to administration of SK was 1.6 + /- 1.4 h. The whole interval to the administration of SK was 4.4 + /- 2.5 h. RESULTS : The 3 criteria of reperfusion (
pain relief , ST changes resolution and less than 18 h maximum
CK rise ) were present in 36 % of the pts , 2 of the criteria in 21 % , and 41 % of the pts had only one or no criteria . -
pubmed
Role of
insulin and counter - regulatory hormones in the control of hepatic
glycerolipid synthesis and low - density - lipoprotein catabolism in
diabetes . -
pubmed
[ High - dose
immunoglobulins in
immune thrombocytopenic purpura ] . -
pubmed
Twenty - four
patients with
immune thrombocytopenic purpura (
ITP ) were treated with high doses of intravenous
immunoglobulin (
Ig ) . -
pubmed
Alpha 1 - fetoprotein and
carbonic anhydrase B and C concentration in cord blood from newborn infants of
diabetic mothers . -
pubmed
[
Prolactin adenoma in a irl whose mother had had a
pituitary adenoma with
amenorrhea -
galactorrhea ] . -
pubmed
Serial renal biopsies for glomerular culture , histochemical staining for
beta - glucuronidase , electron microscopy ( EM ) and light microscopy , were used to study macrophage involvement in experimental chronic immune complex ( IC )
glomerulonephritis (
GN ) induced in
rabbits by daily intravenous injections of
bovine serum albumin (
BSA ) . -
pubmed
We conclude that
opiate receptor stimulation by
morphine causes inhibition of the vagally mediated component of water - induced
bronchoconstriction . -
pubmed
The effect of oral
Kallikrein treatment on sperm motility in
asthenozoospermia . -
pubmed
Nineteen
men with
asthenozoospermia were treated with oral
Kallikrein ( 600 U daily for 12 weeks ) and sperm motility evaluated in 16 of these
patients . -
pubmed
[ Phase-1 study of the tolerance for increasing doses of recombinant
human alpha 2 interferon in
patients with advanced
cancer ] . -
pubmed
Thirteen
patients with
malignant tumors were entered into a phase I trial with recombinant DNA
human alpha 2 interferon (
IFN alpha 2 ) . -
pubmed
Defective
Fc receptor - mediated function of the mononuclear phagocyte system in
lupus nephritis . -
pubmed
To determine whether patients with
systemic lupus erythematosus and
nephritis have more profound defects in mononuclear phagocyte system clearance than their counterparts without
renal disease , we studed
Fc receptor - mediated splenic clearance function in 32
patients . -
pubmed
Neither
B8 nor
DR3 histocompatibility antigen markers differentiated the
renal and nonrenal disease subgroups . -
pubmed
The greater
Fc receptor - mediated
clearance dysfunction , which occurs in
patients with
lupus erythematosus and
nephritis , could lead to enhanced glomerular deposition of immune complexes as a primary event , or as a secondary event amplifying previously established lesions . -
pubmed
A group of
patients with stage T1B2
disease and pathologically negative lymph nodes showed excellent 10 - year survival rates and freedom from clinical evidence of
disease , while
prostate specific antigen (
PSA ) correlations in 10 - year survivors indicate that 88 % were clinically free of
cancer and had a
PSA level of less than 4.0 mg./nl . -
pubmed
In serial samples from nine
posttransfusion hepatitis C patients ,
NS5 and
E2 antibodies did not appear earlier than
classical HCV antibodies . -
pubmed
Re : "
Alcohol , smoking , coffee , and
cirrhosis " and "
coffee and
serum gamma - glutamyltransferase : a study of self - defense officials in Japan " . -
pubmed
[ Antigenemia and
CD4 + cell count in
HIV-1 infected patients ] . -
pubmed
In a peptide competition
cytotoxicity ( PCC ) assay , based on inhibition of CTL lysis by competition for binding to
MHC class - I molecules between a known CTL epitope - containing peptide and peptide of interest ,
E7 49 - 57 bound 45 - fold more efficiently to
Db than the second
Db - binding peptide in line . -
pubmed
The abnormal proliferation of cardiac fibroblasts and deposition of the ECM protein ,
collagen , associated with
hypertension and
myocardial infarction , may adversely affect the performance of the heart . -
pubmed
Angiotensin II ,
aldosterone and
endothelins play a central role in the remodeling of the ECM in
hypertension , and decrease
collagenase activity and/or increase
collagen synthesis in cultured cells . -
pubmed
Angiotensin II is a principal determinant in vivo of
cardiac fibroplasia and synthesis of the ECM proteins ,
collagen and
fibronectin . -
pubmed
Cardiac fibroblasts respond to
angiotensin II with hyperplastic /
hypertrophic growth , and increased expression of
collagen ,
fibronectin , and
integrins . -
pubmed
Association of
protease activity against
IGFBP-3 with peritoneal fluid mitogens : possible implications for the ectopic growth of endometrial cells in
women with
endometriosis . -
pubmed
BACKGROUND : Recent data indicate the implication of an
IGF /
IGFBP /
protease system in the development of ectopic implants of endometrium (
endometriosis ) in the pelvic cavity . -
pubmed
MATERIAL AND METHODS : We characterized mitogens and
protease(s ) against
IGFBP-3 in the peritoneal fluid of
women with or without
endometriosis using preparative isoelectric focusing ( IEC ) Proteineous fractions were tested for a ) mitogenic activity on
NIH / 3T3 cells and
KLE endometrial - like cells , b ) proteinolytic activity against radiolabeled
IGFBP-3 , and c ) protein analysis using
SDS - PAGE . -
pubmed
CONCLUSION : The preparative isoelectric focusing system would be an advantageous approach to investigate the possible implication of the
PF proteases with
IGFBP-3 limited proteolysis generating
PF mitogen(s ) which possibly participate in the pathophysiology of
endometriosis . -
pubmed
Fas - mediated
cytotoxicity was quantified by counting the number of cells present in discrete patches of OSE 0 and 8 h after
Fas mAb treatment . -
pubmed
Further studies should establish whether the
beta3AR is coupled to other signaling pathways in
human brown adipocytes and whether these may contribute to BAT
hypertrophy and/or thermogenesis . -
pubmed
Molecular analysis of the
cholera toxin gene & amp ; antibiotic sensitivity profile of
Vibrio cholerae O1 & amp ;
O139 associated with
mixed infection . -
pubmed
To determine whether glucocorticoid resistance due to mutations in the
glucocorticoid receptor (
GRL ) gene is associated with
premature pubarche ,
hirsutism , or oligo /
amenorrhea , we performed single - strand conformational polymorphism analysis of genomic DNA obtained from 25
children and 16 adolescent
girls referred for the evaluation of
premature pubarche ,
hirsutism , or oligo /
amenorrhea . -
pubmed
We conclude that glucocorticoid resistance due to
GRL mutations is an infrequent cause of mild
hyperandrogenism . -
pubmed
Hb saale OR alpha 2beta 2 84(EF8)Thr --> ; Ala. A new abnormal
hemoglobin was detected in a young German
anemic patient by cation - exchange high performance liquid chromatography ( HPLC ) . -
pubmed
Minor manifestations include
fever ,
arthralgia and laboratory findings of elevated erythrocyte sedimentation rate ,
C - reactive protein and prolonged PR interval on ECG . -
pubmed
[
Telomerase activity in
liver cancer and the adjacent tissue ] . -
pubmed
OBJECTIVE : To investigate the possibility of using
telomerase as a tumor marker for
human primary
hepatocellular carcinomas (
HCC ) . -
pubmed
METHODS :
Human liver specimens , comprising 33
HCC and adjacent peritumoral tissues , 4
hepatic metastases and the adjacent peritumoral tissues , 6
benign liver lesions and 6
normal liver tissues , were examined for
telomerase activity by
TRAP assay based on PCR . -
pubmed
Telomerase activity was negative in 6 nomal liver tissues and 5 of 6 benign
liver lesions . -
pubmed
There was no correlation between the clinical stage of
HCC and their
telomerase activity . -
pubmed
CONCLUSION : Positive
telomerase activity occurs in the majority of
HCC examined . -
pubmed
Subsequent studies suggested that
protein kinase C - dependent and
tyrosine kinase - dependent pathways are important in LB induction during
hypoxia . -
pubmed
Immune system in adults with childhood - onset
growth hormone deficiency : effect of
growth hormone therapy . -
pubmed
OBJECTIVE : To investigate the impact of
growth hormone (
GH ) therapy in
adults with childhood - onset
GH deficiency on immune system . -
pubmed
METHODS : Ten young
GH deficient adults ( 7
males , age 19 - 28 years ) were treated with
recombinant human growth hormone for 6 months . -
pubmed
These observations suggest a temporary immune complex formation after the onset of
GH treatment which might play a partial role in developing
oedema as a side effect of
GH treatment , besides the known effect of
GH on water retention . -
pubmed
CONCLUSIONS :
GH therapy in
GH deficient young
adults has a measurable effect on the increase of
CD4 /
CD8 ratio and on the formation of immune complexes . -
pubmed
Aptamer significantly reduced the
thrombin - induced platelet degranulation ( 46+/-20 % inhibition at 0.15 U / ml
thrombin , P<.001 ) , as well as
thrombin - mediated
platelet aggregation in
PRP ( 7+/-10 % inhibition at 1 U / ml
thrombin , P<.05 ) . -
pubmed
BRCA1 carries
tumor suppressor activity distinct from that of
p53 and
p21 . -
pubmed
The loss of
BRCA1 function appears as an essential step in breast and ovarian epithelial cells oncogenesis and is consistent with the concept that
BRCA1 acts as a
tumor suppressor gene . -
pubmed
In 1996 , a retroviral vector was used for
BRCA1 delivery to demonstrate that the transfer of
BRCA1 inhibits
breast and ovarian cancer cell growth . -
pubmed
Since this early observation , the
tumor growth inhibitory activity of
BRCA1 in vivo has not been further documented . -
pubmed
Delivery of wild - type
BRCA1 by an adenovirus vector in breast and ovarian
tumor cells , decreases in vitro proliferation and tumorigenicity . -
pubmed
Similarly , in vivo administration of
BRCA1 provokes
tumor growth retardation or regression comparable to that obtained with
p53 or
p21 . -
pubmed
[
ACE - dependent and sympathetic components of blood pressure regulation in
patients with essential
hypertension ] . -
pubmed
UNLABELLED : The development of
arterial hypertension is accompanied by impairment of the normal ratio of the "
ACE - depending " and of the sympathetic nervous system , correlates with the action on the main pharmacological " targets " :
I - I - imidazoline receptors (
moxonidine ) or the
ACE activity (
enalapril ) . -
pubmed
The aim of the present investigation was to determine the
hypotensive and metabolic effects of
moxonidine and
enalapril depending on the basal
ACE activity in
patients with
arterial hypertension , complicated with the
metabolic syndrome . -
pubmed
Effectiveness of
moxonidine and
enalapril administration ( during 24 weeks ) depended on the basal
ACE activity in the
hypertensive patients : ( a ) in the group of
patients with low basal
ACE activity
moxonidine very effectively
decreased systolic and diastolic blood pressure , compared with the group of
patients with high basal
ACE activity ; ( b ) influence of
enalapril on the level of arterial blood pressure was more pronounced with high basal
ACE activity . -
pubmed
IN CONCLUSION : choosing a
hypotensive treatment for
patients with the
metabolic syndrome , it is advisable to take into account the basal
ACE activity levels . -
pubmed
Spinal
PGE ( 2 ) application facilitated dorsal horn neuronal firing elicited by ionophoretic delivery of
NMDA , suggesting that an interaction of
PGs and
NMDA receptors may contribute to
inflammation - induced central sensitization . -
pubmed
Maple syrup urine disease (
MSUD ) is an
inborn error of metabolism stemming from a deficiency in
2 - ketoacid dehydrogenase and resulting in the systemic accumulation of branched chain
amino acids (
BCAAs ) . -
pubmed
Misexpression of
dHAND in the anterior compartment of the limb bud induces ectopic expression of
sonic hedgehog , with resulting
preaxial polydactyly and mirror image duplications of posterior digits . -
pubmed
The solute carrier gene family
SLC26 consists of tissue - specific anion exchanger genes , three of them associated with distinct
human recessive disorders . -
pubmed
Interleukin-6 release in the hepatic blood outflow during normothermic
liver ischaemia in
humans . -
pubmed
In
liver ischaemia -
reperfusion injury ,
cytokines play a key proinflammatory role . -
pubmed
AIMS : The aim of our study was to analyse the
cytokine pattern in the hepatic blood outflow in
patients undergoing surgical intervention of partial liver resection with clamping of the hepatic pedicle and
liver ischaemia , and to correlate the
cytokine behaviour with clinical parameters . -
pubmed
RESULTS : We found a significant increase of the
IL-6 levels in the supra - hepatic samples during
liver ischaemia , while the trend with
IL-1alpha was less clear ;
IFN - gamma and
TNF - alpha were undetectable with the methods used . -
pubmed
IL-6 levels appeared to correlate positively with
bilirubin and
gamma - GT levels and negatively with the degree of
acidosis . -
pubmed
Cytokines could contribute to modulate the inflammatory response to
liver ischaemia . -
pubmed
Blockade of
airway inflammation and hyperresponsiveness by
HIV - TAT - dominant negative Ras . -
pubmed
In this study , we evaluated the role of
Ras in
Ag - induced
airway inflammation and
hyperresponsiveness by i.p . -
pubmed
OVA challenge also caused
airway hyperresponsiveness to
methacholine , which was dose dependently blocked by treatment with
TAT - dnRas . -
pubmed
By contrast , TAT -
green fluorescent protein or
dnRas lacking the TAT protein transduction domain did not block
airway inflammation ,
cytokine production , or
airway hyperresponsiveness . -
pubmed
We conclude that
Ras mediates Th2
cytokine production ,
airway inflammation , and
airway hyperresponsiveness in immune - sensitized
mice . -
pubmed
Previous molecular biological analysis documented that
MUTZ-11 cells carry both an
FLT3 internal tandem duplication ( ITD ) and an MLL partial tandem duplication (
PTD ) . -
pubmed
molecular biological alterations (
FLT3 ITD +
MLL PTD ) . -
pubmed
Ligands of
peroxisome proliferator - activated receptor gamma (
PPARgamma ) have been shown to inhibit growth in different
tumor cell lines . -
pubmed
Activation of
PPARgamma by its synthetic ligands might have a therapeutic role in advanced
NB . -
pubmed
A frameshift variant of
CYP2C8 was identified in a
patient who suffered from
rhabdomyolysis after administration of
cerivastatin . -
pubmed
RESULTS :
MMP-2 ,
MMP-9 ,
uPA ,
PAI-1 ,
IGF-2 ,
BFGF ,
VEGF ,
ANG-1 ,
IRS-1 , and
TSP-1 were significantly ( p & lt ; or = 0.05 ) upregulated in
CIS and INV , whereas
TIMP-1 ,
ANG-2 ,
MASPIN ,
IGF1 - R and
HBEGF were unchanged . -
pubmed
IGF-1 was uniquely elevated in
IDP . -
pubmed
SPARC was downregulated in
CIS . -
pubmed
Induction of epithelial cell apoptosis in the uterus by a
mouse uterine ischemia - reperfusion model : possible involvement of
tumor necrosis factor - alpha . -
pubmed
Ischemia - reperfusion - induced endometrial apoptosis was markedly decreased in
TNF - R p55 - deficient
mice , confirming the essential role of
TNFalpha in the induction of apoptosis by
ischemia - reperfusion ( n = 4 ) . -
pubmed
Our results suggest that
ischemia - reperfusion and subsequent
TNFalpha expression may be critical factors in inducing endometrial cell apoptosis . -
pubmed
This finding is of interest because reduction of brain membrane fluidity impairs memory formation and both decreased
PLA2 activity and reduced membrane fluidity have been reported in the brain from
patients with
Alzheimer ' s disease . -
pubmed
However , chronic expression of the
DSCR1 (
Adapt78 ) gene has now been implicated in several pathological conditions including
Alzheimer ' s disease ,
Down syndrome and
cardiac hypertrophy . -
pubmed
Association of
amino acid variants in the
activating transcription factor 6 gene (
ATF6 ) on 1q21 - q23 with
type 2 diabetes in Pima Indians . -
pubmed
Functionally important segments of
ATF6 were sequenced in 15
diabetic and 15 nondiabetic Pimas and representative single nucleotide polymorphisms ( SNPs ) tested for association with
type 2 diabetes in 900 - 1,000 subjects . -
pubmed
Pro(145)
Ala and
Ser(157)
Pro were in a complete linkage disequilibrium and showed a nominal association with
type 2 diabetes ( P = 0.05 ; odds ratio 2.3 [ 95 % CI 1.0 - 5.2 ] ) and with 30 - min plasma
insulin during oral
glucose tolerance test in 287 nondiabetic
individuals ( P = 0.045 ) . -
pubmed
Although the associations with
type 2 diabetes and plasma
insulin levels are marginal and their functional consequences are yet unknown , all three amino acid substitutions are located in a functionally important part of
ATF6 . -
pubmed
Signaling was disrupted by heterologous expression of
TRbeta receptors with mutations in the ligand - binding domain that are associated with
neurological disorders in
humans , but not by mutations that disrupt DNA binding . -
pubmed
Mechanisms regulating
tumor angiogenesis by
12 - lipoxygenase in
prostate cancer cells . -
pubmed
Increased expression of
12 - lipoxygenase has been documented in a number of
carcinomas . -
pubmed
When overexpressed in
human prostate or
breast cancer ,
12 - lipoxygenase promotes
tumor angiogenesis and growth in vivo . -
pubmed
Neutralization of
VEGF by a function - blocking antibody significantly decreased the ability of
12 - lipoxygenase - transfected PC-3 cells to stimulate endothelial cell migration , suggesting
VEGF as an important effector for
12 - lipoxygenase - mediated stimulation of
tumor angiogenesis . -
pubmed
Induction of
Gas6 protein in
CCl4 - induced
rat liver injury and anti - apoptotic effect on hepatic stellate cells . -
pubmed
In liver , after an
acute or chronic injury , repair involves macrophages and hepatic stellate cells ( HSC ) activated into myofibroblastic cells ( HSC / MFB ) , which produce
cytokines and matrix proteins . -
pubmed
Three days after
CCl4 - induced
liver injury in the
rat , we detected the expression of
Gas6 in ED1 - positive macrophages as well as in
desmin - positive HSC , which accumulated in injured areas . -
pubmed
In conclusion ,
Gas6 is a survival factor for these cells and we suggest that
Gas6 , secreted by macrophages and HSC / MFB in vivo after
liver injury , promotes HSC and HSC / MFB survival and might support transient HSC / MFB accumulation during liver healing . -
pubmed
Beta - escin inhibits colonic aberrant crypt foci formation in
rats and regulates the cell cycle growth by inducing
p21(
waf1 /
cip1 ) in
colon cancer cells . -
pubmed
Results also indicate that
beta - escin inhibited growth of
colon cancer cells with either wild - type or mutant
p53 . -
pubmed
Two
autosomal recessive muscle diseases ,
limb girdle muscular dystrophy type 2B (
LGMD2B ) and
Miyoshi myopathy (
MM ) , are caused by mutations in the
dysferlin gene . -
pubmed
However , many patients who share clinical features with
MM - type muscular dystrophy do not carry mutations in
dysferlin gene . -
pubmed
To understand the basis of
MM that is not due to mutations in
dysferlin gene , we analyzed cells from patients in one such family . -
pubmed
These results add to the existing evidence that cell membrane repair defect may be responsible for
MM - type muscular dystrophy and indicate that a previously unsuspected
genetic lesion that affects cell membrane repair pathway is responsible for the disease in the non -
dysferlin MM patients . -
pubmed
Gut
hyperpermiability after
ischemia and reperfusion : attenuation with
adrenomedullin and its binding protein treatment . -
pubmed
Our previous studies have shown that administration of
adrenomedullin (
AM ) , a novel vasoactive peptide , and its binding protein (
AMBP-1 ) , reduces the systemic inflammatory response and
organ injury after
systemic ischemia induced by
hemorrhagic shock . -
pubmed
However , it remains unknown whether administration of AM /
AMBP-1 preserves gut barrier function after gut
ischemia reperfusion ( I / R ) . -
pubmed
We therefore hypothesized that AM /
AMBP-1 prevents structural and functional damages to the intestinal mucosa after gut I / R. To test this ,
gut ischemia was induced by placing a microvascular clip across the superior mesenteric artery ( SMA ) for 90 min in male adult
rats . -
pubmed
Predictive value of
coronary artery stenoses and
C - reactive protein levels in
patients with stable
coronary artery disease . -
pubmed
We sought to assess the prognostic value of non - obstructive coronary stenoses and
C - reactive protein (
CRP ) levels in
patients with
chronic stable angina (
CSA ) . -
pubmed
Age , previous history of
AMI , vessel score , extension score and
CRP levels were significantly associated with the study end - point . -
pubmed
CONCLUSIONS : In
patients with
CSA , independently of revascularization , extension score and
CRP levels predict cardiac adverse events , regardless of the presence or absence of flow limiting
coronary lesions . -
pubmed
Subsequent operation and pathologic examination of the mass revealed a
multicystic neoplasm consisting of malignant mesenchymal cells immunohistochemically positive for
vimentin and
actin . -
pubmed
AIMS : There is no cure for
pulmonary arterial hypertension , but current approved treatment options include
prostanoids ,
endothelin - receptor antagonists , and
phosphodiesterase type-5 inhibitors . -
pubmed
Assessment of
insulin sensitivity / resistance and their relations with
leptin concentrations and anthropometric measures in a pregnant population with and without
gestational diabetes mellitus . -
pubmed
Insulin resistance assessed by homeostasis model assessment for
insulin resistance ( HOMA - IR ) method was significantly higher in
GDM patients compared to their NGT weight - matched control group . -
pubmed
In contrast , the
insulin sensitivity calculated from quantitative
insulin sensitivity check index ( QUICKI - IS ) equation was significantly lower in
GDM group . -
pubmed
Women with
GDM had significantly higher levels of serum
insulin and
leptin concentrations when compared with the NGT group . -
pubmed
We did not find any correlation between
leptin levels and
insulin resistance ; we found negative correlation between
leptin levels and
insulin sensitivity . -
pubmed
Thus , we observed that
leptin may contribute development of
GDM by decreasing
insulin sensitivity but not increasing
insulin resistance . -
pubmed
Telomere maintenance mechanisms , such as
telomerase activity and alternative telomere lengthening , provide the basis of malignant cell expansion independent of telomere shortening - induced apoptosis or senescence , ensuring
tumor survival . -
pubmed
Such a retinal - protein heterogeneity disappears in reduced
bR which is known to have a planar ( nondistorted ) retinal conjugated system , resulting in a monophasic
CD with reduced rotational strength , as observed . -
pubmed
Positive conversion of tuberculin skin test and performance of
interferon release assay to detect hidden
tuberculosis infection during
anti - tumor necrosis factor agent trial . -
pubmed
OBJECTIVES : To evaluate tuberculin skin tests ( TST ) and
interferon - gamma (
IFN - gamma ) assay in the detection of
latent tuberculosis ( TB ) infection during
tumor necrosis factor (
TNF ) antagonist treatment in Korean
patients with initial negative TST result . -
pubmed
METHODS : Eighty - six
patients with
rheumatic diseases who had received anti -
TNF agents for over one year were investigated . -
pubmed
Among 28 TST positive conversion cases , 4
patients with
AS and 1 with
psoriatic arthritis had positive
IFN - gamma assay results , and one of them developed
miliary TB . -
pubmed
However , none of the 4
RA patients with positive
IFN - gamma assay showed TST conversion . -
pubmed
CONCLUSION : Serial TST with
IFN - gamma assay may be useful to identify false - negative response to cases of latent
Mycobacterium tuberculosis infection and new
TB infections in patients with immune mediated
inflammatory diseases during longterm anti -
TNF therapy , especially in areas with intermediate
TB burden . -
pubmed
Three subjects were found to have deletions in the
globin gene cluster , including a
beta - thalassaemia due to deletion of
HBB ( beta -
globin gene ) , an HPFH due to deletions of
HBD ( delta -
globin gene ) and
HBB , and an HPFH due to a novel
HBG2 -
HBG1 fusion gene consisting of exons 1 and 2 of
HBG2 ( ( G)gamma - globin gene ) and exon 3 of
HBG1 ( ( A)gamma -
globin gene ) . -
pubmed
OBJECTIVES : To assess the utility of kinetics for ultrasensitive
prostate - specific antigen (
uPSA ) assays to identify
men who are at risk of developing high - risk recurrent
prostate cancer [
prostate - specific antigen doubling time ( PSADT ) & lt ; 9 months ] after radical prostatectomy . -
pubmed
Role of the
Fcgamma receptor IIIA - V / F158 polymorphism in susceptibility to
systemic lupus erythematosus and
lupus nephritis : a meta - analysis . -
pubmed
OBJECTIVE : To perform a meta - analysis to assess the risk of the
Fc - gamma receptor type IIIA (
FcgammaRIIIA)-V / F158 polymorphism for
lupus nephritis and
systemic lupus erythematosus (
SLE ) . -
pubmed
CONCLUSIONS : The
FcgammaRIIIA - V / F158 polymorphism might be a common susceptibility factor for
SLE and
lupus nephritis and play an important role in the overall development of
SLE , showing different risks within ethnic populations , which should provide novel insights into the pathogenesis of the disease . -
pubmed
This effect has been elucidated to be mediated through modulation of
Achaete - Scute Complex Like 1 (
ASCL1 ) , a transcription factor associated with poor prognosis in
neuroendocrine cancer . -
pubmed
The Notch pathway has been shown to be inactive in
MTC which may lead to altered expression of
ASCL1 . -
pubmed
Artificial induction of Notch signaling in
MTC cells can suppress
ASCL1 expression , the cell growth as well as hormone secreting potential . -
pubmed
Pharmacological activation of the Notch pathway also successfully suppresses the
tumor growth in an animal model , which sheds light on the targeted therapy of
Notch as a potential treatment for intractable
MTC . -
pubmed
Hypoxia - inducible factor-1alpha (
HIF-1alpha ) is a critical regulatory protein of cellular response to
hypoxia , and regulates the transcription of many genes involved in key aspects of
cancer biology , including immortalization , maintenance of stem cell pools , cellular dedifferentiation , vascularization , and invasion / metastasis . -
pubmed
HIF-1alpha has been implicated in the regulation of genes involved in angiogenesis , for example ,
VEGF and is associated with
tumor progression . -
pubmed
In the last decade , over expression of
HIF-1alpha has been demonstrated in many common
human cancers and emerging as a validated target for anticancer drug discovery . -
pubmed
Dissection of the genetics of
Parkinson ' s disease identifies an additional association 5 ' of
SNCA and multiple associated haplotypes at 17q21 . -
pubmed
Although
dyslipidemia is the most influential and least treated factor , the greatest benefit for
CVD prevention is obtained with integrated intervention on all risk factors , reducing blood pressure to below 140/80 mmHg ,
low - density lipoprotein cholesterol (
LDL - c ) to below 100 mg / dl , encouraging smoking cessation , regular physical activity and maintaining a healthy weight ( BMI & lt ; 25 kg / m2 ) . -
pubmed
In secondary prevention or persons with
microvascular disease , the targets may be stricter ( blood pressure 130/80 mmHg and
LDL - c 80 mg / dl ) . -
pubmed
IL-18R protein expression was higher on alveolar macrophages in lung tissue of
COPD patients ( mean 23.2 % ) compared to controls ( mean ex - smokers 2 % and non - smokers 2.5 % ) . -
pubmed
The replication by PCR and protein in different studies confirms these findings , and highlights a potential role for
IL-18R upregulation in severe
COPD . -
pubmed
CONCLUSIONS AND IMPLICATIONS : The present findings suggest that antenatal
nicotine exposure results in the programming of heightened oxidative stress and vascular
hypertensive reactivity via a
Nox2 - dependent mechanism , leading to an increased risk of
hypertension in adult offspring . -
pubmed
Increased
neuronal nitric oxide synthase dimerisation is involved in
rat and
human pancreatic beta cell hyperactivity in
obesity . -
pubmed
AIMS / HYPOTHESIS :
Pancreatic beta cell hyperactivity is known to occur in
obesity , particularly in
insulin - resistant states . -
pubmed
Our aim was to investigate whether changes in
neuronal nitric oxide synthase (
nNOS ) function affect beta cell compensation in two relevant models : the Zucker fa / fa
rats and pancreatic islets from
obese humans . -
pubmed
METHODS :
Glucose - induced
insulin response was evaluated in the isolated perfused
rat pancreas and in
human pancreatic islets from
obese individuals . -
pubmed
Pharmacological blockade of
nNOS was unable to modify beta cell response to
glucose in fa / fa
rats and in islets from
obese individuals , suggesting an abnormal control of
insulin secretion by the enzyme . -
pubmed
CONCLUSIONS / INTERPRETATION : Increased
nNOS production and dimerisation , together with a relative decrease in catalytic activity and relocalisation , are involved in beta cell hyperactivity in
insulin - resistant
rats but also in
human islets isolated from
obese individuals . -
pubmed
A hallmark of immunity to
acute infection is the production of
gamma interferon (
IFN - gamma ) and
interleukin-12 (
IL-12 ) , followed by a protective T cell response that is critical for parasite control . -
pubmed
Contribution of
matrix metalloproteinase-9 to
cerebral edema and functional outcome following experimental
subarachnoid hemorrhage . -
pubmed
Matrix metalloproteinase ( MMP )- 9 is held responsible for the degradation of microvascular basal lamina proteins leading to
blood - brain barrier dysfunction and , thus , formation of vasogenic
cerebral edema . -
pubmed
The current study was conducted to clarify the role of
MMP-9 for the development of
cerebral edema and for functional outcome after
SAH . -
pubmed
METHODS :
SAH was induced in FVB / N wild - type ( WT ) or
MMP-9 knockout (
MMP-9(-/- ) )
mice by endovascular puncture . -
pubmed
MMP-9(-/- )
mice also exhibited better neurological recovery , less
brain edema formation , and lower chronic ICP . -
pubmed
CONCLUSIONS : The results of the current study suggest that
MMP-9 contributes to the development of early
brain damage after
SAH by promoting
cerebral edema formation . -
pubmed
Hence ,
MMP - 9 may represent a novel molecular target for the treatment of
SAH . -
pubmed
CONCLUSION : It seems that neither improvement in imaging results nor
CA-125 level response can predict the survival of ovarian
carcinoma patients prior to interval debulking after neoadjuvant chemotherapy . -
pubmed
The use of immunosuppressant medications and biologics such as
tumor necrosis factor alpha antagonists has revolutionized the treatment of
inflammatory bowel disease . -
pubmed
Novel nonsense mutation in
MSX1 causes
tooth agenesis with
cleft lip in a Chinese family . -
pubmed
Previous studies have attributed
non - syndromic tooth agenesis to mutations in several genes , including
MSX1 ,
PAX9 ,
EDA , and
AXIN2 . -
pubmed
Our findings suggest that the nonsense mutation in
MSX1 might have resulted in rapid degradation of the mutated transcript and caused the phenotype of
tooth agenesis with
cleft lip in the Chinese family . -
pubmed
Heat shock protein 90 inhibitor attenuates renal
fibrosis through degradation of
transforming growth factor - beta type II receptor . -
pubmed
Accumulating evidence suggests that
transforming growth factor ( TGF )- beta1 promotes the development of
renal fibrosis . -
pubmed
Heat shock protein ( Hsp ) 90 inhibitors have been shown to repress
TGF - beta1 signaling , but whether they inhibit renal
fibrosis is unknown . -
pubmed
The purpose of this study is to determine the therapeutic efficacy of
Hsp90 inhibitor on
renal fibrosis . -
pubmed
In
TGF - beta1 - treated
HK2 cells and
unilateral ureteral obstruction ( UUO ) kidneys , we found that
17 - allylamino-17 - demethoxygeldanamycin (
17AAG ) , an
Hsp90 inhibitor , decreased the expression of
alpha - smooth muscle actin ,
fibronectin , and
collagen I and largely restored the expression of
E - cadherin . -
pubmed
The effect of
17AAG on
TbetaRII expression and
renal fibrosis was confirmed in UUO kidneys . -
pubmed
These findings suggest that
Hsp90 inhibitor prevents the development of
renal fibrosis via a mechanism dependent on
Smurf2 - mediated degradation of
TbetaRII . -
pubmed
Aromatase inhibitor ( AI ) therapy for
breast cancer provides an ideal paradigm for studying this issue , because AIs have been the focus of substantial DTCA , and because they should only be used in postmenopausal women , age can serve as a simple surrogate marker of appropriateness . -
pubmed
KRAS mutation analysis on low percentage of
colon cancer cells : the importance of quality assurance . -
pubmed
KRAS mutation testing is mandatory for patients with metastatic
colorectal cancer who are eligible for treatment with an
epidermal growth factor receptor targeting agent , since
tumors with a mutation are not sensitive to the drug . -
pubmed
Toll - like receptor 4 mutation protects
obese mice against
endothelial dysfunction by decreasing
NADPH oxidase isoforms 1 and 4 . -
pubmed
APPROACH AND RESULTS :
Type 2 diabetic mice with mutated
toll - like receptor 4 (
DWM ) were protected from
hyperglycemia and
hypertension , despite an increased body weight . -
pubmed
The in vivo and in vitro administration of lipopolysaccharide caused
endothelial dysfunction in the arteries of wild - type , but not
toll - like receptor 4 - mutated
mice . -
pubmed
CONCLUSIONS :
Toll - like receptor 4 plays a key role in
obesity and
diabetes - associated endothelial dysfunction by increasing oxidative stress . -
pubmed
Granulocyte - colony stimulating factors (
G - CSFs ) enhance bone marrow ( BM ) recovery after autologous stem cell transplant ( ASCT ) in
patients with
lymphoma and
myeloma . -
pubmed
Autocrine
human growth hormone increases sensitivity of
mammary carcinoma cell to
arsenic trioxide - induced apoptosis . -
pubmed
Human growth hormone (
hGH ) has been increasingly implicated in a variety of
cancers ; its up - regulation is observed in
breast cancer and correlates with a poor outcome . -
pubmed
Autocrine
hGH promotes
mammary carcinoma cell survival , proliferation , immortalization ; it confers an invasive phenotype as a result of an epithelial - mesenchymal transition and contributes to chemoresistance and radioresistance . -
pubmed
In the present study , we investigated the effect of
hGH on sensitivity of a
mammary adenocarcinoma cell to
ATO , using a stable
hGH - transfectant
MCF-7 cell line ,
MCF7 - hGH . -
pubmed
Our results demonstrated for the first time that the overexpression of
hGH increased sensitivity of the
breast cancer cell line
MCF-7 to
ATO through apoptotic and anti - proliferative mechanisms . -
pubmed
Our study may highlight the potential application of
ATO for the treatment of
patients with
breast cancer , especially in those who have metastatic and chemoresistant
tumor phenotype possibly due to the over expression of
hGH . -
pubmed
In the present study , we investigated the possible role of the dorsal hippocampal ( CA1 )
dopamine D1 receptors on
scopolamine - induced
amnesia as well as
scopolamine state - dependent memory in adult male
Wistar rats . -
pubmed
Similarly , the pre - test administration of
dopamine D1 receptor agonist ,
1 - phenyl-7,8 - dihydroxy-2,3,4,5 - tetrahydro-1H-3 - benzazepine hydrochloride (
SKF38393 ; 1 , 2 and 4 mug /
rat , intra - CA1 ) , could significantly reverse the
scopolamine - induced
amnesia . -
pubmed
Moreover , while the pre - test intra - CA1 injection of the
dopamine D1 receptor antagonist ,
R (+)- 7 - chloro-8 - hydroxy-3 - methyl-1 - phenyl-2,3,4,5 - tetrahydro-1H-3 - benzazepine hydrochloride (
SCH23390 ; 0.1 and 0.5 mug /
rat , intra - CA1 ) , resulted in apparent
memory impairment , microinjection of the same doses of this agent inhibited the
scopolamine - induced state - dependent memory . -
pubmed
These results indicate that the
CA1 dopamine D1 receptors may potentially play an important role in
scopolamine - induced
amnesia as well as the
scopolamine state - dependent memory . -
pubmed
Furthermore , our results propose that
dopamine D1 receptor agonist ,
SKF38393 reverses the
scopolamine - induced
amnesia via
acetylcholine release and possibly through the activation of
muscarinic receptors . -
pubmed
Alpha-1 - adrenergic receptors in
heart failure : the adaptive arm of the cardiac response to chronic
catecholamine stimulation . -
pubmed
There are far fewer
alpha-1 - ARs than
beta - ARs in the nonfailing heart , but their abundance is maintained or increased in the setting of
heart failure , which is characterized by pronounced chronic elevation of
catecholamines and
beta - AR dysfunction . -
pubmed
Decades of evidence from gain and loss - of - function studies in isolated cardiac myocytes and numerous
animal models demonstrate important adaptive functions for cardiac
alpha-1 - ARs to include physiological
hypertrophy , positive inotropy , ischemic preconditioning , and protection from cell death . -
pubmed
Clinical trial data indicate that blocking
alpha-1 - ARs is associated with incident
heart failure in
patients with
hypertension . -
pubmed
Collectively , these findings suggest that
alpha-1 - AR activation might mitigate the well - recognized toxic effects of
beta - ARs in the hyperadrenergic setting of chronic
heart failure . -
pubmed
Thus , exogenous cardioselective activation of
alpha-1 - ARs might represent a novel and viable approach to the treatment of
heart failure . -
pubmed
We proceed by discussing recently described functions of
Mia40 in the
hypoxia response and of
ALR in influencing mitochondrial morphology and its importance for tissue development and embryogenesis . -
pubmed
The
human TDE2 /
Serinc1 gene was cloned by our laboratory during the screening for differentially expressed genes in
hepatocarcinoma . -
pubmed
In the present study , we knocked down the expression of
TDE2 with specific siRNA fragments in two
human hepatocarcinoma cell lines , and this caused cell cycle arrest at G2 . -
pubmed
In conclusion , our preliminary results indicated that
TDE2 may have an effect on
tumor cell growth by influencing the expression of
SREBP and
p21 . -
pubmed
OBJECTIVE : To evaluate whether administration of
goserelin , a
gonadotropin - releasing hormone (
GnRH ) agonist , could prevent
acute or chronic ovarian insufficiency from
cyclophosphamide (
CTX ) administration to prepubertal
mice . -
pubmed
Changes in plasma levels of
B - type natriuretic peptide with acute exacerbations of
chronic obstructive pulmonary disease . -
pubmed
BACKGROUND : Elevated plasma
B - type natriuretic peptide (
BNP ) levels and their association with
heart failure have been reported in subjects with acute exacerbations of
chronic obstructive pulmonary disease (
AECOPD ) . -
pubmed
PURPOSE : To examine and compare plasma
BNP levels and diastolic and systolic dysfunction in
subjects with
AECOPD and stable
chronic obstructive pulmonary disease (
COPD ) . -
pubmed
RESULTS : In the hospitalized
subjects , the median plasma
BNP level ( interquartile range ) was 55.4 ( 26.9 - 129.3 ) pg / mL and was higher than that of
patients with stable
COPD : 18.3 ( 10.0 - 45.3 ) for Global Initiative for
Chronic Obstructive Lung Disease grade I ; 25.8 ( 11.0 - 53.7 ) for grade II ; 22.1 ( 9.1 - 52.6 ) for grade III ; and 17.2 ( 9.6 - 22.9 ) pg / mL for grade I V , all P<0.001 . -
pubmed
In 15
subjects studied prospectively , the median plasma
BNP level was 19.4 ( 9.8 - 32.2 ) pg / mL before
AECOPD , 72.7 ( 27.7 - 146.3 ) pg / mL during
AECOPD , and 14.6 ( 12.9 - 39.0 ) pg / mL after
AECOPD ( P<0.0033 and P<0.0013 , respectively ) . -
pubmed
Median plasma
BNP levels during
AECOPD were significantly higher in ten unsuccessfully discharged
subjects 260.5 ( 59.4 - 555.0 ) than in 48 successfully discharged subjects 48.5 ( 24.2 - 104.0 ) pg / mL ( P=0.0066 ) . -
pubmed
CONCLUSION : A modest elevation of plasma
BNP is observed during
AECOPD . -
pubmed
It appears that
AECOPD may have an impact on plasma
BNP levels that is not attributable to
heart failure . -
pubmed
CD44v8 - 10 is a
cancer - specific marker for
gastric cancer stem cells . -
pubmed
The surface marker
CD44 has been identified as one of several markers associated with
cancer stem cells ( CSC ) in solid
tumors , but its ubiquitous expression in many cell types , including hematopoietic cells , has hindered its use in targeting CSCs . -
pubmed
Cells that expressed pan -
CD44 were found to occur at significantly higher frequency in gastric
tumor tissues . -
pubmed
We identified
CD44v8 - 10 as the predominant
CD44 variant expressed in
gastric cancer cells and verified its role as a gastric CSC marker by limiting dilution and serial transplantation assays . -
pubmed
Analyses of another 26 primary samples showed significant
CD44v8 - 10 upregulation in gastric
tumor sites . -
pubmed
Exogenous expression of
CD44v8 - 10 but not
CD44 standard (
CD44s ) increased the frequency of
tumor initiation in immunocompromised
mice . -
pubmed
Reciprocal silencing of total
CD44 resulted in reduced
tumor - initiating potential of
gastric cancer cells that could be rescued by
CD44v8 - 10 but not
CD44s expression . -
pubmed
Our findings provide important functional evidence that
CD44v8 - 10 marks
human gastric CSCs and contributes to
tumor initiation , possibly through enhancing oxidative stress defense . -
pubmed
In addition , we showed that
CD44v8 - 10 expression is low in
normal tissues . -
pubmed
Because
CD44 also marks CSCs of numerous
human cancers , many of which may also overexpress
CD44v8 - 10 ,
CD44v8 - 10 may provide an avenue to target CSCs in other
human cancers . -
pubmed
Platelet - derived exosomes suppressed ex vivo
platelet aggregation and reduced adhesion to
collagen - coated microfluidic channels at high shear . -
pubmed
CONCLUSIONS : Platelet - derived exosomes inhibit athero - thrombotic processes by reducing
CD36 - dependent lipid loading of macrophages and by suppressing platelet
thrombosis . -
pubmed
The genetic cause of
CdLS is a mutation in one of five associated genes (
NIPBL ,
SMC1A ,
SMC3 ,
RAD21 , and
HDAC8 ) accounting for about 70 % of cases . -
pubmed
Because recent data indicate a high frequency of mosaic
NIPBL mutations that were not detected by conventional sequencing approaches of blood DNA , we started to collect buccal mucosa ( BM ) samples of our patients that were negative for mutations in the known
CdLS genes . -
pubmed
BDNF blood levels after non - invasive brain stimulation interventions in major
depressive disorder : a systematic review and meta - analysis . -
pubmed
We included trials published in PubMed / Medline from the first date available to June 2014 measuring
BDNF blood levels before and after repetitive transcranial magnetic stimulation or transcranial direct current stimulation in
depression . -
pubmed
CONCLUSIONS : Peripheral
BDNF levels do not increase after NIBS in
depression . -
pubmed
Increased serum concentrations of
adiponectin in
canine hypothyroidism . -
pubmed
Serum concentrations of
adiponectin were compared between sex - matched
hypothyroid ( n = 18 ) and euthyroid ( n = 18 ) client - owned
dogs with comparable ages and body condition scores ( BCS ) . -
pubmed
Concentrations of
adiponectin ( mean ; 95 % confidence interval ) were significantly ( P & lt ; 0.01 ) higher in
hypothyroid ( 17.2 microg / mL ; 12.1 - 20.5 microg / mL ) than healthy ( 8.0 microg / mL ; 5.6 - 11.4 microg / mL )
dogs following adjustment for potential confounders ( BCS , age and sex ) . -
pubmed
Serum concentrations of
adiponectin were significantly negatively associated with concentrations of total
thyroxine ( P & lt;0.05 ) and positively correlated with concentrations of
cholesterol ( r = 0.6 , P & lt;0.01 ) in
hypothyroid dogs . -
pubmed
In conclusion , this study demonstrated increased serum concentrations of
adiponectin in
dogs with
hypothyroidism . -
pubmed
Suggestive of the presence of resistance to
adiponectin that could have contributed to development of
hyperlipidemia and
insulin resistance in these
dogs or alternatively , could be a consequence of these metabolic alterations . -
pubmed
A quadriceps muscle biopsy revealed a chronic inflammatory
myopathy with ubiquitinated inclusion bodies , rimmed vacuoles , expression of
major histocompatibility complex class I , numerous COX - negative fibers and
TDP-43 cytoplasmic aggregates ( features of
IBM ) and
multiple non - necrotizing granulomata ( feature of
sarcoidosis ) . -
pubmed
Because
Erk1 / 2 and
Akt activation has been linked to
tamoxifen - related anti -
estrogen resistance in
breast cancer patients , these results indicate that
omega-3FFA may interfere with the effects of
tamoxifen in the prevention of
breast cancer risk . -
pubmed
The PLR was found to be significantly positively correlated with
CA125 serum level , tumor - node - metastasis ( TNM ) stage , and
tumor differentiation . -
pubmed
Univariate analysis identified
carcinoembryonic antigen (
CEA ) ,
CA125 and
CA199 levels , PLR , TNM stage , and the degree of differentiation as significant prognostic factors for
GBC when they were expressed as binary data . -
pubmed
Multivariate analysis showed that
CA125 & gt ; 35 U / mL , CA199 & gt ; 39 U / mL , PLR & gt;= 117.7 , and TNM stage IV were independently associated with poor survival in
GBC . -
pubmed
Significance of
EGFR signaling pathway genetic alterations in radically resected
non - small cell lung cancers from a Polish cohort . -
pubmed
PURPOSE : We evaluated the distribution and clinical impact of
EGFR ,
KRAS and
HER2 copy number gains and
EGFR ,
KRAS and
BRAF activating mutations in resected
non - small cell lung cancers (
NSCLCs ) from 151 Polish patients . -
pubmed
RESULTS : An increased
EGFR CN was found in 21.2 % of the
tumors , more commonly of the non - squamous histology ( P=0.029 ) , larger in size ( P=0.004 ) and those obtained from women ( P=0.040 ) . -
pubmed
HER2 copy gain was observed in 21.8 % of the patients , more frequently with lymph node metastases ( P=0.048 ) and stage IIIA
disease ( P=0.061 ) . -
pubmed
KRAS gain was found in 29.3 % of the
tumors , and was not associated with patients ' clinicopathological features . -
pubmed
EGFR and
KRAS mutation frequency and associations with clinicopathological characteristics did not differ significantly from those previously described for the
NSCLC patients of Caucasian ethnicity . -
pubmed
In the multivariate model ,
EGFR mutations constituted an independent prognostic factor of the
disease recurrence in
adenocarcinoma patients ( HR 7.20 ; 95%CI 1.31 - 39.48 ; P=0.023 ) , while an increased
EGFR copy number tended to indicate a shorter overall survival ( HR 4.85 ; 95%CI 0.92 - 25.58 ; P=0.062 ) . -
pubmed
CONCLUSIONS :
EGFR pathway genes alterations are frequent in
NSCLCs from Polish patients and have a prognostic potential for
patients ' clinical outcome after a curative
tumor resection . -
pubmed
Herein , we focused on the
ganglioside GM2 tumor - associated carbohydrate antigen (
TACA ) , which is overexpressed in a wide range of
tumor cells . -
pubmed
In contrast ,
GM2 immobilized on Qbeta through a
thiourea linker elicited high titers of
IgG antibodies that recognized
GM2 - positive tumor cells and effectively induced cell lysis through complement - mediated
cytotoxicity . -
pubmed
TBMS1 exerts its
cytotoxicity in
NCI - H460 lung cancer cells through nucleolar stress - induced
p53 /
MDM2 - dependent mechanism , a quantitative proteomics study . -
pubmed
Tubeimoside-1 (
TBMS1 ) exerts its anticancer effects by inducing G2 / M arrest and apoptosis of
cancer cells . -
pubmed
Functional validation demonstrated that
TBMS1 - induced
NCI - H460 cell
cytotoxicity involved nucleolar stress - induced
p53 /
murine double minute clone 2 (
MDM2 ) ,
mTOR , and
NF - kappaB signaling pathways . -
pubmed
Mutations in the
CBS gene cause clinical
CBS deficiency , a disease characterized by elevated plasma total
homocysteine ( tHcy ) and
methionine and decreased plasma
cysteine . -
pubmed
RESULTS : The messenger RNA ( mRNA ) expression of the inflammatory
cytokines interleukin-1 beta (
IL-1beta ) and
IL-8 and of
matrix metalloproteinase ( MMP )- 3 ( a catabolic gene ) in both the synovium and the labrum , and the expression of
collagen type I alpha 1 ( an anabolic gene ) in the labrum , was higher in the samples from hips with
OA than in those from hips with
FAI ( p & lt ; 0.05 ) . -
pubmed
In cartilage , however , the mRNA expression of the inflammatory
cytokines and the catabolic genes
MMP-13 and
ADAMTS-4 ( a disintegrin and metalloproteinase with
thrombospondin motifs-4 ) was higher in the FAI samples compared with the
OA samples ( p & lt ; 0.01 ) . -
pubmed
When the expression of inflammatory
cytokines was evaluated among the three types of tissues within each disease group , the expression levels were the highest in cartilage within the
FAI samples ( p & lt ; 0.01 ) . -
pubmed
In
FAI cartilage , we found higher gene expression of
aggrecan (
ACAN ) and
ADAMTS-4 in the samples from patients with larger alpha angles ( & gt;=60 ) ( p & lt ; 0.01 ) . -
pubmed
Heterogeneous Contribution of
Insulin Sensitivity and Secretion Defects to
Gestational Diabetes Mellitus . -
pubmed
In
women with
GDM ( 8.3 % ) , defects in
insulin sensitivity or secretion were defined below the 25th percentile in women with
normal glucose tolerance ( NGT ) . -
pubmed
While the general mechanism underlying this observation is deficient
CD4+T - cell function , it is unknown whether increased severity of
herpes virus infections is due primarily to poor immune control in latent or lytic sites of infection , or whether
CD4 + immunodeficiency leads to more critical downstream deficits in humoral or cell - mediated immunologic responses . -
pubmed
TL was used to determine the effects of
iron deficiency on
photosystem II (
PSII ) activity . -
pubmed
The effect of
iron deficiency on the
photosystem I (
PSI ) activity was also examined by measuring the changes in P700 redox state during illumination . -
pubmed
The results of this work suggest that
iron deficiency induces partial blocking of the electron transfer between
PSII and
PSI , due to a lower concentration of the electron donor
cytochrome c 6 . -
pubmed
Preoperative
Hemoglobin A1c and the Occurrence of
Atrial Fibrillation Following On - pump Coronary Artery Bypass Surgery in Type-2 Diabetic
Patients . -
pubmed
BACKGROUND : We investigated the association of the preoperative
hemoglobin A1c (
HbA1c ) with occurrence of postoperative
atrial fibrillation (
POAF ) in type-2 diabetic
patients who underwent isolated coronary artery bypass grafting . -
pubmed
CONCLUSIONS : Serum level of
HbA1c could not be used as a predictor for the development of
POAF . -
pubmed
The
Janus tyrosine kinase 2 mutation can be used as a key diagnostic tool for diagnosing
MPDs , specifically ,
ET ,
PV , and
PMF . -
pubmed
Our observation may explain why some viruses responsible for
virological failure in patients treated with
dolutegravir did not show mutations in the
integrase gene . -
pubmed
HLA - B*52:01 - C*12:02 , which is found in approximately 20 % of all Japanese persons , is well known to be associated with
ulcerative colitis and
Takayasu arteritis . -
pubmed
Association of
Lipoprotein ( a ) With Risk of Recurrent Ischemic Events Following
Acute Coronary Syndrome : Analysis of the dal - Outcomes Randomized Clinical Trial . -
pubmed
Importance : It is uncertain whether
lipoprotein ( a ) [
Lp ( a ) ] , which is associated with incident
cardiovascular disease , is an independent risk factor for recurrent cardiovascular events after
acute coronary syndrome (
ACS ) . -
pubmed
Objective : To determine the association of
Lp ( a ) concentration measured after ACS with the subsequent risk of
ischemic cardiovascular events . -
pubmed
Conclusions and Relevance : For patients with recent
ACS who are treated with
statins ,
Lp ( a ) concentration was not associated with adverse cardiovascular outcomes . -
pubmed
These findings call into question whether treatment specifically targeted to reduce
Lp ( a ) levels would thereby lower the risk for
ischemic cardiovascular events after ACS . -
pubmed
The
Abeta1 - 42 dimer is the smallest oligomer of the 42 - residue
Abeta peptide (
Abeta1 - 42 ) , which is involved in
Alzheimer ' s disease . -
pubmed
Unilateral
IGF-1 injection for
mandibular asymmetry . -
pubmed
Elevation of
antimullerian hormone in
women with
polycystic ovary syndrome undergoing assisted reproduction : effect of
insulin . -
pubmed
OBJECTIVE : To measure blood and follicular antimullerian hormone (
AMH ) levels in
women with
polycystic ovary syndrome (
PCOS ) undergoing assisted reproductive technologies ( ART ) and to examine the direct action of
insulin on
AMH expression in
human granulosa cells . -
pubmed
RESULT(S ): Serum levels of
AMH were elevated and inversely correlated with embryo cleavage rate in
PCOS women in ART . -
pubmed
Significant higher levels of
AMH were also found in small and large follicles collected from
PCOS women compared with non -
PCOS women . -
pubmed
Luteinized granulosa cells from
PCOS women showed higher expression of
AMH and its receptor
AMHR2 . -
pubmed
Direct effect of
insulin in increasing the expression of
AMH in the isolated luteinized granulosa cells was observed , with the
PCOS granulosa cells responding to a high dose of
insulin . -
pubmed
CONCLUSION(S ): These results suggest that
insulin may contribute to
AMH elevation in
PCOS and that
AMH counteracts
insulin - promoted
aromatase expression in granulosa cells . -
pubmed
The discovery that women in endemic regions develop a certain immunity against
VAR2CSA - expressing parasites with increasing number of pregnancies has redefined the understanding of
malaria in pregnancy and offers strategies for the development of vaccines . -
pubmed
RESULTS : A decrease in the frequency of
ARVI in
patients with
CHF treated with
Amixin was found , which was accompanied by a decrease in the severity of subclinical
inflammation by reducing the production of proinflammatory (
IL-1beta ) and increasing the production of anti - inflammatory (
IL-10 )
cytokines , reducing neurohumoral activation ( reducing levels of
aldosterone and
Nt - proBNP ) , increasing the level of
alpha - and gamma - interferon . -
pubmed
NLRP3 inflammasome expression in peripheral blood monocytes of
coronary heart disease patients and its modulation by
rosuvastatin . -
pubmed
The present study aimed to determine the expression of
NLRP3 inflammasome in peripheral blood monocytes ( PBMCs ) of
stable angina pectoris (
SAP ) and
acute myocardial infarction (
AMI )
patients . -
pubmed
NLRP3 inflammasome was expressed in the PBMCs , and revealed an increased expression along the downstream
interleukin ( IL )- 1beta and
IL-18 in both SAP and
AMI groups , compared to the control group . -
pubmed
Interference with
rosuvastatin in vitro revealed that the expression of
NLRP3 inflammasome and its downstream
cytokines were significantly downregulated in both
SAP and
AMI groups in a time - dependent manner . -
pubmed
The activation of
NLRP3 inflammasome may be involved in the development of
CHD , and
rosuvastatin could attenuate the inflammatory process of
atherosclerosis by downregulating
NLRP3 expression and its downstream mediators . -
pubmed
These findings indicated a potential role of
NLRP3 in the pathogenesis and management of
CHD , and also provided new insights into the mechanistic framework of
rosuvastatin activity . -
pubmed
Heme Oxygenase Upregulation in
Obesity and the
Metabolic Syndrome . -
pubmed
CRITICAL ISSUES :
Heme Oxygenase plays an ever increasing role in the understanding of
human biology in the fields of
obesity and the
metabolic syndrome . -
pubmed
miR-30b-3p Inhibits Proliferation and Invasion of
Hepatocellular Carcinoma Cells via Suppressing
PI3K /
Akt Pathway . -
pubmed
TRIM27 was demonstrated to have an oncogenic role in
HCC cells by enhancing cell viability , proliferation , migration , and invasion . -
pubmed
Finally , the miR-30 - 3p -
TRIM27 -
PI3K /
Akt axis was shown to play a crucial role in
HCC cells in vitro . -
pubmed
Objective : In this study , we investigated the antitumor activity of
interleukin ( IL )- 18 on
A549 human lung cancer cell line and evaluated the potential of
IL-18 therapy in
lung cancer . -
pubmed
Conclusion : Using a lentiviral expression vector ,
IL-18 was expressed stably and efficiently in
A549 cells , which showed attenuated proliferation and
tumor cell growth , and enhanced
tumor cell apoptosis . -
pubmed
These findings further demonstrated the antitumor activity of
IL-18 and might open new therapeutic avenues for the prevention and treatment of
lung cancer . -
pubmed
A triplet repeat expansion leading to transcriptional silencing of the
FMR1 gene results in
fragile X syndrome (
FXS ) , which is a common cause of
inherited intellectual disability and
autism . -
pubmed
Regulation of miR-125a has been associated with
type I metabotropic glutamate receptor signaling (
mGluR ) , which has been explored as a treatment target for
FXS , reinforcing the possibility that urine miR-125a may provide a novel biomarker for
FXS . -
pubmed
KEGG enrichment analysis found that
cortisol regulated LPS - stimulated immune responses mainly focus on
cytokines , complement and coagulation cascades pathways , antigen presentation pathways , haematopoiesis , and
inflammation . -
pubmed
[ Pharmaco - resistance and side effects of antipsychotics associated with poor metabolizer phenotype for
cytochrome P450 2D6 in a context of early - onset
schizophrenia : A case report ] . -
pubmed
We measured
microvascular dysfunction at baseline by use of flicker light - induced
retinal vessel dilation response ( Dynamic Vessel Analyzer ) , heat - induced skin
hyperemic response ( laser- Doppler flowmetry ) , and plasma markers of
endothelial dysfunction (
endothelial dysfunction ;
sICAM-1 [ soluble
intercellular adhesion molecule-1 ] ,
sVCAM-1 [ soluble
vascular adhesion molecule-1 ] ,
sE - selectin [ soluble
E - selectin ] , and
vWF [
Von Willebrand Factor ] ) . -
pubmed
LncRNA
HOTAIR - mediated
MTHFR methylation inhibits
5 - fluorouracil sensitivity in
esophageal cancer cells . -
pubmed
RESULTS : We found reciprocal expression patterns of lncRNA
HOTAIR and
MTHFR in
EC tissues and
human EC cells . -
pubmed
Interference with lncRNA HOTAIR enhanced
5 - FU - induced apoptosis , exhibited anti - proliferative activity , and reduced promoter methylation of the
MTHFR in
EC cells . -
pubmed
Besides , overexpression of
MTHFR attenuated the acquired chemoresistance induced by overexpression of lncRNA
HOTAIR in
EC cells . -
pubmed
CONCLUSION : Together , our study proposes that pharmacologic targeting of lncRNA HOTAIR sensitizes
EC cells to
5 - FU - based chemotherapy by attenuating the promoter hypermethylation of the
MTHFR in
EC . -
pubmed
Roles of
follicle stimulating hormone and its receptor in
human metabolic diseases and
cancer . -
pubmed
Follicle stimulating hormone (
FSH ) and its receptor (
FSHR ) play an important role in
human metabolic diseases and
cancer . -
pubmed
Evidence showed that
FSHR is not only distributed in ovary and testis but also in other cells or organs such as osteoclast , adipocytes , liver ,
pituitary cancer and so forth . -
pubmed
Moreover ,
FSH is associated with lipogenesis ,
inflammation ,
insulin sensitivity , thermogenesis , skeletal metabolism , osteogenesis and
ovarian cancer , all of which have been confirmed closely related to
metabolic diseases or
metabolic - related cancer . -
pubmed
Therefore ,
FSH and
FSHR may be potential therapeutic targets for
metabolic diseases and
metabolic - related cancer . -
pubmed
Epidemiological researches revealed close relationship between
FSH /
FSHR and
metabolic diseases or
cancer . -
pubmed
We reviewed the recent researches and present an integrated framework of
FSH /
FSHR and
metabolic diseases and
cancer , which provides potential targets for the treatments of
metabolic diseases and
cancer . -
pubmed
Common causes of death in
COVID-19 due to
SARS - CoV-2 include
thromboembolic disease ,
cytokine storm and
adult respiratory distress syndrome (
ARDS ) . -
pubmed
An attempt was made to identify predictive elements for
thromboembolism ,
cytokine storm and
ARDS based on physiological measurements and blood tests , and to communicate to clinicians managing the patient , initially via single consultants . -
pubmed
Thromboembolism and
cytokine storm flags were met in the ED for 342 ( 37.1 % ) patients . -
pubmed
YAP increases response to Trastuzumab in
HER2 - positive
Breast Cancer by enhancing
P73 - induced apoptosis . -
pubmed
The role of the
Yes - associated protein (
YAP ) in oncogenesis and progression of
breast cancer remains controversial . -
pubmed
Meanwhile , development of therapeutic resistance to trastuzumab , a common
breast cancer treatment administered after chemotherapy , is a significant challenge in the treatment of
HER2 - positive
breast cancer . -
pubmed
We , therefore , analyzed the role of
YAP in trastuzumab resistance in
HER2 - positive -
breast carcinoma cells in vitro and evaluated the status of
YAP and related proteins in patient - derived
breast carcinoma tissues by immunohistochemistry . -
pubmed
Our results show that
YAP is involved in trastuzumab resistance in
HER2 - positive
breast carcinoma cells and that
YAP and
AKT may be developed as prognostic markers of neoadjuvant trastuzumab therapy in
patients with
HER2 - positive
breast cancer . -
pubmed
CD34 + ,
CD45 + , white blood cell , and
lymphocyte counts decreased , with the lowest levels also observed at EOT ( P < .001 ) . -
pubmed
Fatigue and
insomnia were associated with changes in both
interferon gamma - induced protein 10 (
IP-10 ) - ( P = .03 and P = .01 , respectively ) and
tumor necrosis factor receptor II (
TNF - RII ) ( P = .02 and P = .006 , respectively ) , while
mental fatigue was associated with increased
matrix metalloproteinases-2 (
MMP-2 ) levels ( P = .03 ) . -
pubmed
Conclusions : This is the first longitudinal study to examine linkages between symptoms , HSCs , and
cytokines , demonstrating that
fatigue and
insomnia shared associations with increasing serum levels of
IP-10 and
TNF - RII , and
mental fatigue was associated with increasing serum levels of
MMP-2 . -
pubmed
Mice experiment also showed that
curcumol could alleviate
chronic liver injury by reducing
KLF5 expression . -
pubmed
SIGNIFICANCE : We suggested that transcription factor
KLF5 could be considered as a new target molecule of
curcumol in improving
liver fibrosis , and pointed out that
curcumol targeted ROS /
ERK - mediated
KLF5 expression could inhibit LSEC angiogenesis . -
pubmed
ANRIL has a convincing potential to be used as an additive therapeutic tool in
TAA and
AAA . -
pubmed
[ Effects of
propranolol on plasma lipids and
renin activity in young
men with labile borderline
hypertension ( author 's transl ) ] . -
pubmed
In our two cases ( and in one of the previous cases ) , the syndrome was preceded by a sudden increase in the amount of
serum immunoglobulin M antibody to
cytomegalovirus . -
pubmed
Platelet 5 - HT2 serotonin receptor binding sites in
autistic children and their first - degree relatives . -
pubmed
We examined platelet
serotonin2 [
5 - hydroxytryptamine2 ( 5 - HT2 ) ] receptor binding sites , whole blood
serotonin ( 5 - HT ) , and plasma
norepinephrine ( NE ) in male
autistic children and their first - degree relatives . -
pubmed
[ Changes in the dietary regimen during treatment of
type I diabetes mellitus with continuous
insulin infusion . -
pubmed
UNLABELLED : The authors investigated in 11 type diabetics the effect of omission of a meal on the compensation of
diabetes during treatment with an
insulin pump IP 1003 . -
pubmed
Several lines of evidence indicate that
neutrophil elastase and oxidants secreted by phagocytic inflammatory cells play key roles in the development of centrilobular
emphysema . -
pubmed
In follow - up studies of 10
patients admitted for acute
alcoholism ,
elastase activity and
superoxide production remained low for 2 to 4 days . -
pubmed
Production of monoclonal antibody to
thyroglobulin from
malignant thyroid carcinoma . -
pubmed
In this study , the production of anti -
human thyroglobulin (
Tg ) monoclonal antibodies was attempted to detect
Tg levels in serum and to study the localization of
thyroid metastases in
patients with thyroid - gland ablation . -
pubmed
Our monoclonal antibody ,
2G4 , will be a hopeful reagent for the diagnosis in
thyroid carcinoma . -
pubmed
Beta 2 - adrenoceptor responsiveness of the airways after inhaled
adenosine and
histamine was further studied in 12
asthmatic subjects by observing the antibronchoconstrictor effect of inhaled
isoproterenol . -
pubmed
Arylsulfatase A and B activities have been determined in urine samples from four
patients who received a Kidney allograft from living donors as a treatment for terminal
uraemia . -
pubmed
Dose - response studies of mitogen stimulation with
phytohemagglutinin and concanavalin A revealed generally higher proliferative responses in the
psoriatic patients only at supraoptimal concentrations . -
pubmed
Patients with
PSR had significantly higher mean cell
haemoglobin and lower
Hb F levels on average than the matched controls , but the viscosity and erythrocyte filtration indices did not differ between the 2 groups . -
pubmed
Since
aspartic acid is a putative excitatory neurotransmitter , a possible causal relationship is suggested between its increased
CSF concentration and the occurrence of
neonatal convulsions in this family . -
pubmed
Selective
alpha-1 blockers seem to be useful in
patients with uncomplicated
benign prostatic hyperplasia and mild to moderate symptoms . -
pubmed
Superoxide dismutase activities and mRNA levels were not affected by
hyperoxia , whereas
catalase activity was slightly decreased after 24 h in 80 %
oxygen at Day 17 . -
pubmed
Glutathione peroxidase activity was markedly decreased already after 12 h of
hyperoxia , and decreased activities of
glutathione reductase and
glucose-6 - phosphate dehydrogenase were also noted . -
pubmed
To determine if
Muerto Canyon Virus (
MCV ) RNA is present in the peripheral blood of patients with
hantavirus pulmonary syndrome , a
reverse transcriptase - polymerase chain reaction ( RT - PCR ) assay for
MCV RNA was used on blood samples from 20 seropositive case - patients . -
pubmed
The presence of
mGluR1 alpha in cells of the hippocampus that are associated with the release of
somatostatin , suggest that this receptor could play a role in regulating hippocampal excitability in both normal and
epileptic tissues . -
pubmed
Collagen synthesis in intact skin is suppressed during
wound healing . -
pubmed
OBJECTIVE : Simultaneous monitoring of total
collagen synthesis as well as synthesis in intact skin and in the wound to verify the higher priority of
wound healing after surgery . -
pubmed
The authors hypothesized a lower priority in synthesis of structural and peripheral
collagen for the benefit of
wound healing . -
pubmed
CONCLUSIONS :
Collagen synthesis is regulated for the benefit of the
wound during the acute phase response . -
pubmed
High molecular weight
phospholipase A2 and
fatty acids in
human colon
tumours and associated
normal tissue . -
pubmed
Compared with
normal mucosa / submucosa , there was more total
arachidonate in
tumours ( P & lt ; 0.01 ) , and increased levels of
cPLA2 occurred in 6 of 17
tumours . -
pubmed
In conclusion , the higher amounts of
tumour total
arachidonate and the sometimes higher levels of
cPLA2 , might help to explain why some
human colon
tumours form increased amounts of
PGs . -
pubmed
Most cases are associated with
X - linked Alport syndrome and have partial deletions in the genes encoding both the
alpha5 and alpha6 chains of collagen type IV . -
pubmed
In
DL , a primary abnormality of basement membrane may be associated with disorganization of the contractile apparatus and alterations of certain
integrins . -
pubmed
We assessed the anticoagulant effects of
acenocoumarol with INR ,
factors VII and X and
protein C in 12 randomly selected hospitalised
patients with
deep - vein thrombosis , six of them receiving a daily dose of
acenocoumarol , the other six receiving twice daily doses . -
pubmed
The
CCl4 administration alone caused
hepatocellular necrosis , severe
anemia ,
leucopaenia ,
lymphocytopaenia ,
neutrophilia ,
eosinophilia and
haemoglobinaemia along with the alterations of
plasma albumin and
globulin . -
pubmed
Thyroid peroxidase (
TPO ) as a
tumor marker in the follow - up of differentiated
thyroid carcinomas with surgical and ablative
radioiodine therapy . -
pubmed
The clinical significance of
serum thyroid peroxidase (
TPO ) for differentiated
thyroid carcinomas(
DTA ) is estimated differently . -
pubmed
Therefore ,
TPO seems to be an indicator for the destruction of normal thyroid cells or
thyroid tumor cells . -
pubmed
Sera of
children with
hepatitis C infection and anti - liver - kidney microsome-1 antibodies recognize different
CYP2D6 epitopes than adults with LKM+/
HCV+ sera . -
pubmed
BACKGROUND :
Liver - kidney microsome type 1 ( LKM1 ) antibodies are specific markers of
autoimmune hepatitis (
AIH ) type 2 . -
pubmed
Antibodies to
LKM1 have been found in 2 % to 3 % of
adults infected with hepatitis C virus (
HCV ) without
AIH . -
pubmed
LKM1 antibodies in
HCV+/LKM1 + sera and in sera of
AIH patients do not recognize the same
CYP2D6 epitopes . -
pubmed
The current study was conducted to determine whether
LKM1 antibodies in
HCV+/LKM1 + children 's sera are the result of the same immune response as the antibodies described in
AIH type 2 and in
HCV+/LKM1 + adult patients . -
pubmed
Screening of
HCV RNA should be performed before starting treatment of presumed
autoimmune hepatitis associated with
LKM1 . -
pubmed
In this report , we investigated methylation status and the expression of the
AR gene in
normal endometrium and
uterine endometrial cancer (
UEC ) tissues using methylation - specific polymerase chain reaction ( MSP ) and immunohistochemical staining . -
pubmed
By MSP , 64 of 89
cancer samples showed only methylated
AR alleles , although all
normal tissues showed both unmethylated and methylated
AR alleles . -
pubmed
To determine whether similar changes occurred in methylation status in the UEC
carcinogenesis , we studied
AR methylation using pairs of
cancerous and
normal samples from 28 patients . -
pubmed
Twenty - three of 28
cancer samples showed only methylated
AR alleles , although all
normal samples showed both unmethylated and methylated alleles . -
pubmed
All of the 23
cancer samples that lost unmethylated alleles were negative for
AR by immunohistochemical analysis . -
pubmed
This study is the first to report that the possible mechanism of
AR inactivation in
endometrial cancer is through hypermethylation of the
AR gene
CpG islands . -
pubmed
There is compelling evidence that topical
corticosteroids down - regulate
cytokine expression , and it is likely that a larger , and longer multi - centre trial may prove their efficacy in
CRS . -
pubmed
Effect of short - term fasting on free and bound
leptin concentrations in lean and
obese women . -
pubmed
The purpose of this study was to evaluate the effect of short - term fasting on bound and free plasma
leptin concentrations and
leptin binding capacity ( a measure of plasma
leptin - binding protein content ) in lean and
obese women . -
pubmed
Although total plasma
leptin concentration was more than 6 - fold greater in
obese ( 45.4 + /- 7.6 microg / liter ) compared with lean ( 7.4 + /- 1.0 microg / liter )
women at 14 h of fasting ( P & lt ; 0.05 ) , the percentage of
leptin in the bound form was greater in lean than
obese subjects ( 29 + /- 2 % vs. 12 + /- 3 % ; P & lt ; 0.05 ) . -
pubmed
Arterial total , free , and bound plasma
leptin concentrations all declined between 14 h and 22 h of fasting in both lean and
obese groups , but the relative decline of these fractions was greater in lean ( 36 + /- 4 % , 60 + /- 9 % , and 51 + /- 13 % , respectively ) than in
obese ( 19 + /- 5 % , 21 + /- 8 % , and 12 + /- 7 % , respectively ) subjects ( all P & lt ; 0.05 ) . -
pubmed
The percentage of total plasma
leptin present in bound form was constant between 14 h and 22 h of fasting in lean
subjects and increased slightly but significantly in
obese subjects . -
pubmed
Cytokine - induced
metabolic dysfunction of
MIN6 beta cells is
nitric oxide independent . -
pubmed
BACKGROUND : An important obstacle to islet transplantation is
graft injury due to local production of
cytokines generated by host nonspecific inflammatory responses . -
pubmed
We tested the in vitro effects of
interleukin ( IL )- 1 beta ,
tumor necrosis factor ( TNF ) alpha , and
interferon ( IFN ) gamma on
glucose - stimulated
insulin release in the
MIN6 beta - cell line and correlated
metabolic dysfunction with
NO production and rates of apoptosis . -
pubmed
Complete remission in
hypoplastic acute myeloid leukemia induced by
G - CSF without chemotherapy : report on three cases . -
pubmed
Hypoxia upregulates
VEGF expression in alveolar epithelial cells in vitro and in vivo . -
pubmed
We investigated regulation of
vascular endothelial growth factor (
VEGF ) expression by
hypoxia in cultured and freshly isolated
rat alveolar epithelial cells ( AEC ) . -
pubmed
In vitro ,
hypoxia increased
VEGF mRNA and protein levels , with maximal stimulation at 0 %
O2 for 18 h. A similar upregulation of
VEGF expression was found in alveolar epithelial type II ( ATII ) cells freshly isolated from
rats exposed to 8 %
O2 for 24 h. In vitro ,
hypoxia - induced upregulation of
VEGF mRNA was due to an increase in transcription , rather than an increase in RNA stability , inasmuch as the half - life of
VEGF mRNA was unchanged . -
pubmed
Upregulation of
VEGF mRNA by
hypoxia was mimicked by
CoCl2 and
desferrioxamine in normoxic AEC and was not prevented by inhibitors of reactive
oxygen species , suggesting that hypoxic
VEGF regulation involved an
O2 - dependent protein that requires
ferrous ions but is independent of reactive
oxygen species generation . -
pubmed
Hypoxia induced a twofold increase in
VEGF protein at the apical side of ATII cells in culture and in bronchoalveolar lavage fluid . -
pubmed
Improved erectile function after
Rho - kinase inhibition in a
rat castrate model of
erectile dysfunction . -
pubmed
Our data support the hypothesis that an active
Rho /
Rho - kinase pathway contributes to the reduced erectile response after castration due to an upregulation of
RhoA /
Rho - kinase protein levels and that inhibition of this pathway may serve as an effective treatment for
erectile dysfunction . -
pubmed
Nitroglycerine administration results in a delayed
migraine - like
headache in
migraine patients but not in control
patients , and a nonspecific
nitric oxide synthase inhibitor aborted
migraine at 2 hours in the majority of tested
migraine patients compared to controls . -
pubmed
Many
patients with
familial hemiplegic migraine have a missense mutation in the
P / Q calcium channel , so that this form of
migraine , at least , is associated with a demonstrable
calcium channelopathy . -
pubmed
These data show region - specific differences of
IL-1beta mRNA expression in the brain of these
rat strains that differ in their susceptibility to
inflammation . -
pubmed
Maspin in
thyroid cancer : its relationship with
p53 and clinical outcome . -
pubmed
The
serine protease inhibitor
maspin has been reported to inhibit invasiveness and motility of
tumor cells . -
pubmed
Additionally , a
p53 - dependent regulatory pathway of
maspin in
human cancer has been indicated . -
pubmed
In a pre - study we were able to detect
maspin protein in
papillary thyroid carcinomas (
PTC ) , whereas
normal (
tumor - free ) thyroid tissue , follicular
adenomas ,
follicular carcinomas , poorly differentiated
carcinomas and
undifferentiated carcinomas of the thyroid were
maspin - negative . -
pubmed
The first aim of our study was to determine the prognostic value of
maspin protein expression for the recurrence - free and overall survival of
PTC patients undergoing radical thyroidectomy and postoperative irradiation . -
pubmed
Mutant - type
p53 expression was detectable in 17 of 68
PTC ( 25 % ) . -
pubmed
This study indicates that
maspin protein possibly functions as a clinically relevant inhibitor of
tumor progression , preventing local invasiveness and further systemic progression of
papillary thyroid carcinomas . -
pubmed
Our data hint of a
p53 - dependent regulatory pathway of the
maspin protein in
human cancer . -
pubmed
In this study we demonstrate that
IL-4Rs are expressed on
human hepatocellular carcinoma (
HCC ) cells . -
pubmed
Acetylcholine and
cholinesterase in the blood of
patients suffering with
bronchial asthma . -
pubmed
High prevalence of
type b beta - lactamase - non - producing
ampicillin - resistant
Haemophilus influenzae in
meningitis : the situation in Japan where Hib vaccine has not been introduced . -
pubmed
OBJECTIVES : To study yearly changes in resistance and to identify
ftsI mutations in
beta - lactamase - non - producing
ampicillin - resistant ( BLNAR ) and
TEM-1 beta - lactamase - producing
amoxicillin /
clavulanic acid - resistant ( BLPACR ) isolates of
Haemophilus influenzae from patients with
meningitis . -
pubmed
To assess the biotransformation pathways of
aplidine and their potential implications for
human pharmacology and toxicology , the in vitro metabolism of
aplidine was characterized using incubations with
human plasma , liver preparations ,
cytochrome P450 (
CYP ) and
uridine diphosphoglucuronosyl transferase (
UGT ) supersomes in combination with HPLC analysis and
cytotoxicity assays with cell lines . -
pubmed
In accordance with the findings in microsomes and
CYP supersomes , a significant effect of specific
CYP2A6 ,
2E1 ,
3A4 and
4A11 inhibitors on the
cytotoxicity of
aplidine in
Hep G2 and
IGROV-1 cells could be observed . -
pubmed
IGF - I therapy in
growth disorders . -
pubmed
Patients with
GH insensitivity , typically resulting from mutations affecting the
GH receptor (
GHR ) ,
GHR signaling cascade , or the
IGF - I gene , are , generally , unresponsive to
GH therapy . -
pubmed
As interest in the potential efficacy of
IGF - I treatment for
children currently labeled as
idiopathic short stature increases , it will be important to have controlled clinical trials of GH , versus
IGF - I versus combination ,
GH +
IGF - I. -
pubmed
The protein amount of
TGF - beta ( 1 ) and
BMP-2 in myocardium of
AMI was significantly higher than that in normal myocardium . -
pubmed
These in vitro and in vivo results suggest that
infarct - related biological and physical factors in
AMI induce commitment of MSCs to cardiomyocyte - like cells through
TGF - beta /
BMP-2 pathways . -
pubmed
Identification of downstream targets of
estrogen and
c - myc in
breast cancer cells . -
pubmed
These data indicate that a significant component of E - induced mitogenesis is mediated by
c - myc and that selected
c - myc target genes may be surrogate markers of c - myc expression in
BC . -
pubmed
FUS is a member of the
Ewing ' s sarcoma family of proteins that appears to play a role in regulating genome stability , since
mice lacking
FUS show chromosomal instability and defects in meiosis . -
pubmed
Expression of
chemokine receptor CCR7 is associated with cervical lymph node metastasis of
oral squamous cell carcinoma . -
pubmed
Tumor cell migration and metastasis share many similarities with leukocyte trafficking , which is critically regulated by
chemokines and their receptors . -
pubmed
The present study was designed to examine the expression of
chemokine receptor CCR7 in
oral squamous cell carcinoma (
OSCC ) , and to investigate the possible role of
CCR7 /
CCL21 interaction in neck lymph node metastasis of
OSCC . -
pubmed
By using immunohistochemistry , RT - PCR and Western Blot , expression of
CCR7 was examined in 85 cases of
oral squamous cell carcinoma , and
Tca8113 and ACC cell lines . -
pubmed
In vitro adhesion assay was shown for banding of
tumor cell lines to submandibular lymph nodes with or without anti -
CCR7 antibody treatment . -
pubmed
Immunohistochemical staining showed 65.9 % ( 56/85 ) of positive
CCR7 expression in
OSCC tissues . -
pubmed
CCR7 expression was significantly higher in
patients with lymph node metastasis compared with those without lymph node metastasis ( P=0.015 ) and was also associated with
tumor size ( P=0.014 ) , and clinical stage ( P=0.009 ) . -
pubmed
RT - PCR and Western Blot also confirmed positive
CCR7 expression in
oral squamous cell carcinoma and
Tca8113 cell line , and negative
CCR7 expression in
normal oral mucosa and ACC cell line . -
pubmed
These results indicated that the chemotactic
CCR7 /
CCL21 interaction may be a possible mechanism for induction of directional lymph node metastasis by
oral squamous cell carcinoma . -
pubmed
The treatment of
pertussis and
pneumonia complicating
pertussis ; the role of
hyperimmune gamma globulin and
sulfadiazine . -
pubmed
Carbonyl Reductase 3 (
CBR3 ) Mediates
9 - cis - Retinoic Acid - Induced
Cytostatis and is a Potential Prognostic Marker for
Oral Malignancy . -
pubmed
Our results suggest that the cytostatic effects of
RA could be mediated by the activation of endogenous
CBR3 gene in
oral squamous cell carcinomas (
OSCCs ) , and the expression is a potential marker for
oral malignancy . -
pubmed
In view of the central role of
connective tissue growth factor (
CCN2 ) in
fibrosis , we investigated the mechanisms by which
CCN2 is regulated in
PSC following their exposure to
ethanol or
acetaldehyde . -
pubmed
The potential therapeutic effects of inhibitors of
ethanol metabolism or anti - oxidants in
alcoholic pancreatitis may arise in part through their ability to attenuate
CCN2 production by PSC . -
pubmed
The incretins and beta - cell health : contrasting
glucose - dependent insulinotropic polypeptide and
glucagon - like peptide-1 as a path to understand islet function in
diabetes . -
pubmed
Loss of
polycystin-2 (
PC2 ) in
mice (
Pkd2(-/- ) ) results in total body
edema , focal
hemorrhage , structural
cardiac defects , abnormal left - right axis ,
hepatorenal and pancreatic cysts , and
embryonic lethality . -
pubmed
Global inactivation of
Pkd2 produced a phenotype identical to
Pkd2(-/- )
mice with undetectable
PC2 protein and
perinatal lethality . -
pubmed
Our results suggest that loss of
PC2 disrupts normal behavior of renal epithelial cells through dysregulation of
beta - catenin - dependent signaling , revealing a potential role for this signaling pathway in
PC2 - associated
ADPKD . -
pubmed
COX-2 Gene increases
tongue cancer cell proliferation and invasion through
VEGF - C pathway . -
pubmed
COX-2 induces the proliferation and invasion of
oral squamous cell carcinoma . -
pubmed
A short hairpin RNA ( shRNA)method was used to knock down
COX-2 gene expression and investigate the relationship between
COX-2 and
VEGF - C , and the role of the
COX-2 gene for proliferation and invasion was also investigated in the
tongue cancer cell
Tca8113 . -
pubmed
COX-2 gene overexpressed in
tongue cancer cell line . -
pubmed
Our results suggested that
COX-2 played essential roles in the proliferation and metastasis of
tongue cancer , and
COX-2 could serve as a potential chemotherapy target for
tongue cancer . -
pubmed
The
envelope glycoprotein gp120 of the
human immunodeficiency virus (
HIV ) , the causative agent of
AIDS , contains approx 24 potential sites for N - glycosylation (
Asn - X - Ser /
Thr , X Pro ) ( 1 ) , all of which are utilized and constitute about 50 % of the molecular mass ( 2 ) . -
pubmed
TNF alpha antagonist - induced
lupus - like syndrome : report and review of the literature with implications for treatment with alternative
TNF alpha antagonists . -
pubmed
OBJECTIVE : To review clinical characteristics of
patients who develop
tumor necrosis factor ( TNF ) alpha antagonist - induced
lupus - like syndrome (
TAILS ) and review implications for further
TNF alpha antagonist therapy . -
pubmed
Published reports of
individuals who have developed
TAILS and those who have continued treatment with alternative
TNF alpha antagonists are reviewed . -
pubmed
To date , 10
patients with
TAILS have continued therapy with an alternative
TNF alpha antagonist without recurrence of
lupus symptoms . -
pubmed
CONCLUSIONS : Development of a
DILS after one
TNF alpha antagonist does not preclude continued treatment with an alternative
TNF alpha antagonist . -
pubmed
Multiple endocrine neoplasia type 1 (
MEN1 ) results from mutations in the
tumor suppressor gene ,
MEN1 , which encodes nuclear protein
menin . -
pubmed
4 )
Menin represses certain pro - proliferative factors involved in endocrine
tumors such as
IGFBP-2 ,
IGF2 and
PTHrP to repress cell proliferation . -
pubmed
In the two
diabetic groups , one group (
diabetes mellitus ,
DM ) was fed a common semi - purified diet while the other group received a diet in which part of the
casein was replaced by GLN ( DM - GLN ) . -
pubmed
The results showed that blood
thioredoxin - interacting protein (
Txnip ) mRNA expression in the
diabetic groups was higher than that in the NC group . -
pubmed
INTRODUCTION : An international cohort study of 73 anti - Ku - positive
patients with different
connective tissue diseases was conducted to differentiate the anti - Ku - positive populations of patients based on their autoantibody profile and clinical signs / symptoms and to establish possible correlations between antibodies against
Ku p70 and
Ku p80 with
autoimmune diseases . -
pubmed
By using the first and the third components of the principal - component analysis ( PCA ) with 29 parameters evaluated , we observed that the anti -
Ku - positive population of
UCTD patients had overlapping parameters , especially with
SLE , as opposed to
SSc , which could be helpful in delineating
UCTD patients . -
pubmed
A major subgroup of MMPs , the
gelatinases (
MMP9 and 2 ) are central to many adult physiological and pathological processes , such as
tumor metastasis and angiogenesis , in which cell - cell and cell - matrix contacts are degraded to allow migration . -
pubmed
As
NCC undergo similar processes during development , we hypothesized that
MMP9 may also promote the migration of
NCC . -
pubmed
Altogether , our study reveals
MMP9 as a novel effector which is required for
NCC delamination and migration . -
pubmed
S100A12 as a marker to predict cardiovascular events in
patients with chronic
coronary artery disease . -
pubmed
BACKGROUND :
S100A12 , a calgranulin family protein released from white blood cells , is involved in
inflammatory cardiovascular disease . -
pubmed
It was hypothesized that the plasma level of
S100A12 can be used to predict outcome in
patients with chronic
coronary artery disease (
CAD ) . -
pubmed
The purpose of this study was to clarify the clinical significance of
S100A12 in
patients with stable
CAD . -
pubmed
CONCLUSIONS :
S100A12 could be a novel biomarker for predicting cardiovascular events for predicting MACE in
patients with stable
CAD . -
pubmed
Influence of the
IL6 gene in susceptibility to
systemic sclerosis . -
pubmed
Interleukin 6 (
IL-6 ) plays a crucial role in immunity and
fibrosis , both key aspects of
SSc . -
pubmed
We investigated the influence of
IL6 gene in the susceptibility and phenotype expression of
SSc . -
pubmed
In the
IL6 allelic combination analyses , the GGC allelic combination rs2069827 - rs1800795 - rs2069840 showed an association with overall
SSc ( Bonferroni p = 0.016 , OR 1.13 , 95 % CI 1.04 - 1.23 ) . -
pubmed
CONCLUSION : Our results suggest that the
IL6 gene may influence the development of
SSc and its progression . -
pubmed
Addiction to cigarette smoking is a prevalent
neuropsychiatric disorder that stems from the biophysical and cellular actions of
nicotine on
nicotinic acetylcholine receptors (
nAChRs ) throughout the central nervous system . -
pubmed
Understanding the various
nAChR subtypes that exist in brain areas relevant to
nicotine addiction is a major priority . -
pubmed
Preoperative elevation of
carcinoembryonic antigen predicts poor
tumor response and frequent distant recurrence for
patients with rectal
cancer who receive preoperative chemoradiotherapy and total mesorectal excision : a multi - institutional analysis in an Asian population . -
pubmed
PURPOSE : This study was conducted to evaluate the significance of
carcinoembryonic antigen (
CEA ) level as a predictor for
tumor response to chemoradiotherapy ( CRT ) and a prognosticator for survival in Asian
patients with advanced
rectal cancer . -
pubmed
Increased
CEA level ( p = 0.025 ) was a significant negative predictor of ypCR after CRT in
patients with
rectal cancer . -
pubmed
CONCLUSIONS : Elevated
CEA ( & gt;5 ng / mL ) is a negative predictor of ypCR and has a negative impact on DFS in Asian
rectal cancer patients who underwent preoperative CRT and surgery due to an increased chance of distant recurrences . -
pubmed
BACKGROUND : Hemorrhagic transformation (
HT ) following acute
ischemic stroke is a major problem , especially for the indication of reperfusion therapy including intravenous administration of recombinant
tissue plasminogen activator (
IV rt - PA ) . -
pubmed
In conclusion , South Indian adult males have
Hb values similar to American male adults , but South Indian females have considerably lower
Hb levels than American females , raising the questions about appropriateness of WHO or US criteria for detection of
anemia in Indian females . -
pubmed
Toll - like receptor 4 : innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major
depressive disorder . -
pubmed
The current review presents evidence that
toll - like receptor 4 (
TLR4 ) , via driving both peripheral and central immune responses , can interact with serotonergic neurotransmission and cause neuroendocrine disturbances , thus integrating with widely observed hallmarks of
MDD . -
pubmed
Additionally , through describing the multi - directional communication between immune , neural and endocrine systems in stress ,
TLR4 - related mechanisms can mediate stress - induced adaptations , which are necessary for the development of
MDD . -
pubmed
Therefore , apart from exogenous pathogenic mechanisms ,
TLR4 is involved in immune changes as a result of endogenous stress signals , playing an integral part in the pathophysiology , and could be a potential target for pharmacological treatments to improve current interventions for
MDD . -
pubmed
Regarding
insulin dynamics , among the
NAFLD subjects with both IFG and an HbA1c level of 5.7 - 6.4 % , 25.2 % ( 31/123 ) had elevated IR alone , 25.2 % ( 31/123 ) had
insulin secretory deficiency alone and 27.6 % ( 34/123 ) had both elevated
insulin resistance and
insulin secretory deficiency . -
pubmed
CONCLUSION :
NAFLD subjects with
IFG and an
HbA1c level of 5.7 - 6.4 % should undergo OGTT in order to determine whether they have
diabetes and/or abnormal
insulin dynamics . -
pubmed
Novel gain of function mutation in the
SLC40A1 gene associated with
hereditary haemochromatosis type 4 . -
pubmed
Here we report the case of a 69 - year - old Chinese Han woman who presented with
liver cirrhosis ,
diabetes mellitus ,
skin hyperpigmentation ,
hyperferritinaemia and high
transferrin saturation . -
pubmed
BACKGROUND :
Monophosphoryl lipid A ( MPLA ) , a nontoxic
TLR4 ligand derived from lipopolysaccharide ( LPS ) , is used clinically as an adjuvant in
cancer ,
hepatitis , and
malaria vaccines and in allergen - specific immunotherapy . -
pubmed
Stromal expression of
ALDH1 in
human breast
carcinomas indicates reduced
tumor progression . -
pubmed
Aldehyde dehydrogenase 1 (
ALDH1 ) is a recognized
cancer stem cell marker but little is known about its role in intratumoral stroma . -
pubmed
Therefore , we focused on
ALDH1 expression in tumor - associated stroma of
breast carcinomas (
BrCa ) . -
pubmed
Stromal and tumoral
ALDH1 expression was evaluated immunohistochemically in
BrCa and their lymph node
metastases (
LNMs ) , and related to clinico - pathological characteristics ,
patients ' outcome , presence of
CD68 ,
HLADR ,
retinoic acid ( RA ) in stroma , and selected proteins in
tumor cells . -
pubmed
ALDH1(+ ) stromal cells were detected in 53 % of 374
BrCa and 61 % of 102
LNMs . -
pubmed
ALDH1(+ ) stroma in primary
tumor correlated to longer
disease - free ( p = 0.030 ) , metastasis - free ( p = 0.024 ) , and overall survival ( p = 0.043 ) having an independent prognostic impact on DFS ( multivariate analysis , p = 0.047 ) . -
pubmed
It was associated with concomitant presence of
HLA - DR(+ ) stromal cells and RA in
tumor cells ( both p & lt ; 0.001 ) , and inversely associated with
vimentin expression in
tumor cells ( p = 0.036 ) . -
pubmed
ALDH1(+ ) stroma in
LNMs correlated inversely to presence of disseminated
tumor cells in
patients ' bone marrow ( p = 0.014 ) and was independent prognosticator of shorter DFS and MFS ( multivariate analysis , p = 0.004 and p = 0.002 , respectively ) . -
pubmed
In conclusion ,
ALDH1 expression in
tumor - associated stromal cells indicates reduced BrCa progression , possibly via RA secretion . -
pubmed
Genetic variants of the
POMC and
PCSK1 genes cause severe
obesity among patients in the early stages of childhood . -
pubmed
This family - based study analyzed the links between single
nucleotide polymorphisms ( SNPs ) in either the
POMC or
PCSK1 genes and
obesity , as well as
obesity - related traits among obese Thai children and their families . -
pubmed
The variants rs1042571 and rs6713532 in the
POMC gene in a sample of 83
obese children and their family members were investigated using polymerase chain reaction ( PCR)-restriction fragment length polymorphism . -
pubmed
However , this analysis did not find any correlation between
obesity and SNPs in
PCSK1 and
POMC . -
pubmed
Therefore , these common variants in
PCSK1 and
POMC were not the major cause of
obesity in the Thai subjects sampled . -
pubmed
In terms of
ZnO - NP - induced
cytotoxicity pIL8 - RFP cells were the most affected , whilst the pIL8 -
Luc were found the least responsive . -
pubmed
Cancer - Specific Synthetic Lethality between
ATR and
CHK1 Kinase Activities . -
pubmed
ATR and
CHK1 maintain
cancer cell survival under replication stress and inhibitors of both
kinases are currently undergoing clinical trials . -
pubmed
Indeed , we observe that replication stress induced by the
CHK1 inhibitor
AZD7762 results in replication catastrophe and apoptosis , when combined with the
ATR inhibitor
VE-821 specifically in
cancer cells . -
pubmed
Combined treatment with
ATR and
CHK1 inhibitors leads to replication fork arrest , ssDNA accumulation , replication collapse , and synergistic cell death in
cancer cells in vitro and in vivo . -
pubmed
In conclusion , this study exemplifies
cancer - specific synthetic lethality between two proteins in the same pathway and raises the prospect of combining
ATR and
CHK1 inhibitors as promising
cancer therapy . -
pubmed
Rapid detection and quantification of
tumor marker
carbohydrate antigen 72 - 4 (
CA72 - 4 ) using a superparamagnetic immunochromatographic strip . -
pubmed
This study highlighted novel roles of
EIF2S3Y in the pluripotency maintenance and proliferation control of ES cells , which would provide an efficient model to study germ cell generation as well as
cancer development using ES cells , thus providing valuable target for clinical applications of ES cells . -
pubmed
Association of Single
Nucleotide Polymorphisms in the Apoptosis - Related Genes
TP63 and
CD40 with Risk for
Lung Cancer in a Chinese Han Population . -
pubmed
Two single nucleotide polymorphisms ( SNPs ) , rs6790167 ( g243059A>G ) in intron 9 of
TP63 and rs1535045 ( g6194C>T ) in intron 1 of
CD40 respectively , may affect the susceptibility of
lung cancer . -
pubmed
Thus , the polymorphisms in the
TP63 and
CD40 genes are associated with
lung cancer in a Chinese Han population . -
pubmed
CD133 , Selectively Targeting the Root of
Cancer . -
pubmed
Tfh-2 cells recently emerged in
humans as a strong
IL-4 producer Tfh cell subset implicated in both autoimmune and
allergic diseases . -
pubmed
INTRODUCTION :
Ospemifene is a selective
estrogen receptor modulator recently approved by the FDA for the treatment postmenopausal
women experiencing moderate - to - severe
dyspareunia and by the EMA for the treatment of moderate - to - severe symptomatic
genitourinary syndrome of menopause ( GSM ) in
women who are not suitable candidates for local vaginal
estrogen therapy . -
pubmed
Arginine deiminase (
ADI ) , an
arginine degrading enzyme isolated from
Mycoplasma , can inhibit the growth of these
tumors . -
pubmed
Tumor cells do not express an enzyme called
arginosuccinate synthetase (
ASS ) and hence , these cells become auxotrophic for
arginine . -
pubmed
The
PARP inhibitor
AZD2461 was developed as a next - generation agent following
olaparib , the first
PARP inhibitor approved for
cancer therapy . -
pubmed
Here we demonstrate the efficacy of this compound against
olaparib - resistant
tumors that overexpress
P - glycoprotein . -
pubmed
CONCLUSION : The
PDE4 inhibitor
roflumilast has a favorable side - effect profile at a cognitively effective dose and could be considered as a treatment in disorders affected by
disrupted sensory gating . -
pubmed
Involvement of
mitogen activated kinase kinase 7 intracellular signalling pathway in
Sunitinib - induced
cardiotoxicity . -
pubmed
The
tyrosine kinase inhibitor
Sunitinib is used to treat
cancer and is linked to severe adverse cardiovascular events . -
pubmed
Mitogen activated kinase kinase 7 (
MKK7 ) is involved in the development of
cardiac injury and is a component of the
c - Jun N - terminal kinase (
JNK ) signal transduction pathway . -
pubmed
This study investigates the role of
ASK1 ,
MKK7 and
JNK during
Sunitinib - induced
cardiotoxicity . -
pubmed
Left ventricular cardiac tissue samples were analysed by qRT - PCR for
MKK7 mRNA expression and
cardiotoxicity associated microRNAs ( miR-1 , miR-27a , miR-133a and miR-133b ) or Western blot analysis to measure
ASK1 /
MKK7 /
JNK phosphorylation . -
pubmed
Co - administration of
NQDI-1 ( 2.5 muM ) attenuated the increased
Sunitinib - induced
infarct size , reversed miR-133a expression and restored phosphorylated levels of
ASK1 /
MKK7 /
JNK . -
pubmed
These findings suggest that the
ASK1 /
MKK7 /
JNK intracellular signalling pathway is important in
Sunitinib - induced
cardiotoxicity . -
pubmed
Investigations into the
ASK1 /
MKK7 /
JNK transduction pathway could lead to development of cardioprotective adjunct therapy , which could prevent
Sunitinib - induced
cardiac injury . -
pubmed
Arabidopsis (
Arabidopsis thaliana ) mutants defective in the expression of the
OVARIAN TUMOR DOMAIN - CONTAINING DEUBIQUITINATING ENZYME5 (
OTU5 ) exhibited a constitutive
Pi deficiency root phenotype , comprising the formation of long and dense root hairs and attenuated primary root growth . -
pubmed
[ Expressions of
CD96 and
CD123 and Their Relationship with Prognosis of Patients with
Myelodysplastic Syndrome ] . -
pubmed
OBJECTIVE : To explore the relationship between expression of
CD96 and
CD123 and prognosis of
patients with
myelodysplastic syndrome(
MDS ) . -
pubmed
RESULTS : The proportion of
CD34 + cells and
CD34+
CD38- cells in mononuclear cells of
patients in
MDS group was higher than in control group ( P<0.05 ) . -
pubmed
CONCLUSION : The differentiation of CD34 + cells in bone marrow of
MDS patients is abnormal , and the high expression of
CD123 and
CD96 cells existes . -
pubmed
The
tumor suppressor and cell polarity protein
lethal-2 - giant larvae (
Lgl ) promotes
Hippo signaling and inhibits Notch signaling to restrict tissue growth in
Drosophila melanogaster Notch signaling is greater in
lgl mutant tissue than in wild - type tissue because of increased acidification of endosomal vesicles , which promotes the proteolytic processing and activation of
Notch by
gamma - secretase . -
pubmed
Our findings implicate the deregulation of
Vap33 and
V - ATPase activity in polarity - impaired
epithelial cancers . -
pubmed
The emergence of cryptic self - antigens such as the
LAIR1 ligand
ColV during
ischemia /
reperfusion injury and early acute rejection , as well as the tendency of macrophages / monocytes to accumulate in the allograft during chronic rejection , favors Th17 over Th1 development , posing a risk to long - term graft survival . -
pubmed
AAV9 - mediated
telomerase activation does not accelerate tumorigenesis in the context of oncogenic
K - Ras - induced
lung cancer . -
pubmed
This opens the possibility of using
telomerase activation as a potential therapeutic strategy to rescue short telomeres both in
telomere syndromes and in age - related diseases , in this manner maintaining tissue homeostasis and ameliorating these diseases . -
pubmed
In the past , we generated adeno - associated viral vectors carrying the
telomerase gene ( AAV9 -
Tert ) and shown their therapeutic efficacy in
mouse models of
cardiac infarct ,
aplastic anemia , and
pulmonary fibrosis . -
pubmed
Although we did not observe increased
cancer incidence as a consequence of
Tert overexpression in any of those models , here we set to test the safety of AAV9 - mediated
Tert overexpression in the context of a
cancer prone
mouse model , owing to expression of oncogenic
K - ras . -
pubmed
We found that overexpression of
Tert does not accelerate the onset or progression of
lung carcinomas , even when in the setting of a
p53 - null background . -
pubmed
These findings indicate that
telomerase activation by using AAV9 - mediated
Tert gene therapy has no detectable cancer - prone effects in the context of oncogene - induced
mouse tumors . -
pubmed
High miR-718 Suppresses
Phosphatase and Tensin Homolog (
PTEN ) Expression and Correlates to Unfavorable Prognosis in
Gastric Cancer . -
pubmed
BACKGROUND
Phosphatase and tensin homolog (
PTEN ) is a kind of phosphatase which has been demonstrated to suppress progression of
gastric cancer . -
pubmed
Many micro - RNAs ( miRNAs ) , such as miR-106b , miR-93 , and miR-200c , could inhibit expression of
PTEN in cell lines ; and many miRNAs including miR-21 , miR-22 , miR-18a , and miR-222 are related to the progression and prognosis of
gastric cancer . -
pubmed
MATERIAL AND METHODS The expression of
PTEN and miR-718 in 141
gastric cancer tissues were detected by immunohistochemistry and quantitative real - time PCR respectively . -
pubmed
RESULTS Low expression of
PTEN and high expression of miR-718 were both significantly associated with unfavorable prognosis , and both were identified as biomarkers predicting poorer prognosis of
patients with
gastric cancer . -
pubmed
CONCLUSIONS Low expression of
PTEN and increased expression of miR-718 in
gastric cancer tissues were both independent unfavorable prognostic factors of
gastric cancer . -
pubmed
Upregulation of miR-718 could increase
PI3K /
Akt signaling by directly downregulating
PTEN , thus promoting the proliferation and invasion of
gastric cancer cells . -
pubmed
Elevated Sera
sST2 Is Associated With
Heart Failure in Men & lt;=50 Years Old With
Myocarditis . -
pubmed
Elevated sera soluble ( s )
ST2 predicts mortality from acute and chronic
heart failure , but has not been studied in
myocarditis patients . -
pubmed
Sera
sST2 levels were higher in healthy men ( P=8x10 - 6 ) and men with
myocarditis ( P=0.004 ) compared with women . -
pubmed
sST2 levels were elevated in patients with
myocarditis and New York Heart Association class III - IV
heart failure ( P=0.002 ) , predominantly in men ( P=0.0003 ) . -
pubmed
Sera
sST2 levels were associated with New York Heart Association class in men with
myocarditis who were & lt;=50 years old ( r=0.231 , P=0.0006 ) , but not in women ( r=0.172 , P=0.57 ) . -
pubmed
Sera
sST2 levels were also significantly higher in male
mice with
myocarditis ( P=0.005 ) where levels were associated with
cardiac inflammation . -
pubmed
Gonadectomy with hormone replacement showed that
testosterone ( P<0.001 ) , but not
estradiol ( P=0.32 ) , increased sera
sST2 levels in male
mice with
myocarditis . -
pubmed
Conclusions We show in a well - characterized subset of
heart failure patients with clinically suspected and biopsy - confirmed
myocarditis that elevated sera
sST2 is associated with an increased risk of
heart failure based on New York Heart Association class in men & lt;=50 years old . -
pubmed
A direct Coombs - negative
hemolytic anemia combined with an increased
LDH =
Lactate dehydrogenase level are signs to test for
PNH . -
pubmed
Expression , purification , and in vitro mitochondrial interaction analysis of full - length and truncated
human tumor suppresser
p53 . -
pubmed
They were found to have low serum
phosphorus , normal
calcium , and
vitamin D studies , with elevated
alkaline phosphatase suggestive of
nutritional hypophosphatemia . -
pubmed
Histopathologically , the superficially located
tumor showed typical features of
PXA with melanin - laden astrocytic component and was negative for V600E - mutant
BRAF . -
pubmed
TTP399 : an investigational liver - selective
glucokinase (
GK ) activator as a potential treatment for
type 2 diabetes . -
pubmed
Introduction :
Type 2 diabetes is a complex
metabolic disorder defined by
hyperglycemia which occurs because of impaired
insulin secretion and sensitivity . -
pubmed
TTP399 is a hepatoselective ,
glucokinase activator with potential for treating
type 2 diabetes . -
pubmed
CONCLUSION : The standard treatment of
hormone receptor positive and
HER-2 negative metastatic
breast cancer is
everolimus together with
exemestane . -
pubmed
Thus , we aimed to elucidate the preventive effect of
inosine on locomotor activity , changes in
purine levels , and
adenosine receptors density in a
ketamine - induced model of
mania in
rats . -
pubmed
Inosine pretreatment ( 25 mg / kg , oral route ) prevented the
hyperlocomotion induced by
ketamine ( 25 mg / kg , intraperitoneal route ) in the open - field test ; however , there was no difference in hippocampal density of
A1 and
A2A receptors , where
ketamine , as well as
inosine , were not able to promote changes in immunocontent of the
adenosine receptors . -
pubmed
In this sense , we suggest further investigation of signaling pathways involving
purinergic receptors , using pharmacological strategies to better elucidate the action mechanisms of
inosine on
bipolar disorder . -
pubmed
Direct Determination of
Coagulation Factor IIa and
Plasmin Activities for Monitoring of
Thrombotic State . -
pubmed
Factor IIa and
plasmin activities could be dynamically monitored in
patients with
thrombotic disease who were taking oral anticoagulants and used for assessing the hypercoagulable state in pregnant
women . -
pubmed
CONCLUSIONS : The high specificity , sensitivity , and stability of this novel assay not only makes it useful for determining clinically important
protease activities in
human blood and diagnosing
thrombotic diseases but also provides a new way to monitor the effectiveness and safety of anticoagulant drugs . -
pubmed
The
paracaspase mucosa - associated lymphoid tissue lymphoma translocation protein-1 (
MALT1 ) regulates
nuclear - factor - kappa - B (
NF - kappaB ) activation downstream of surface receptors with immunoreceptor
tyrosine - based activation motifs ( ITAMs ) , such as the
B - cell or T - cell receptor and has thus emerged as a therapeutic target for
autoimmune diseases . -
pubmed
However , recent reports demonstrate the development of lethal
autoimmune inflammation due to the excessive production of
interferon gamma (
IFN - gamma ) and defective differentiation of regulatory T - cells in genetically modified
mice deficient in
MALT1 paracaspase activity . -
pubmed
Treatment with an allosteric
MALT1 inhibitor alleviated the
cytokine storm , including
IFN - gamma , in a
mouse model of acute T - cell activation , and long - term treatment did not lead to an increase in
IFN - gamma producing CD4 cells or
tissue inflammation . -
pubmed
Together , our data demonstrate that the effects of allosteric inhibition of
MALT1 differ from those seen in
mice with proteolytically inactive
MALT1 , and thus we believe that
MALT1 is a viable target for B and T - cell driven
autoimmune diseases . -
pubmed
CONCLUSION : It can be concluded that
resveratrol modulated
alveolar bone loss during experimental
periodontitis progression in
estrogen - deficient
rats by downregulating
NADPH oxidase levels . -
pubmed
Such 3D constructs generally have a naturally occurring
hypoxic center , which allows for the stabilization of
HIF-1alpha in the interior tissue . -
pubmed
High mobility group box 1 induces
bone pain associated with bone invasion in a
mouse model of advanced
head and neck cancer . -
pubmed
Recurrent
SPECC1L -
NTRK fusions in
paediatric sarcoma and
brain tumours . -
pubmed
The identification of rearrangements driving expression of
Neurotrophic Receptor Tyrosine Kinase ( NTRK ) family kinases in
tumours has become critically important due to the availability of effective , specific inhibitor drugs . -
pubmed
Here we describe three
SPECC1L -
NTRK fusions identified in two paediatric
central nervous system cancers and an
extracranial solid tumour using WGS and RNAseq . -
pubmed
We report here that
SPECC1L -
NTRK fusions can arise in a range of
paediatric cancers . -
pubmed
Galeterone sensitizes
breast cancer to chemotherapy via targeting
MNK /
eIF4E and
beta - catenin . -
pubmed
Aberrant activation of
eIF4E signalling pathway is common in
breast cancer and holds potential therapeutic options . -
pubmed
In our work ,
galeterone as a chemical compound under clinical trials for the treatment of
prostate cancer , was identified to be effective in targeting
breast cancer cells via suppressing
MNK -
eIF4E and
beta - catenin . -
pubmed
Rescue studies demonstrated that both
MNK /
eIF4E and
beta - catenin were responsible for anti -
breast cancer activity of
galeterone . -
pubmed
LncRNA
PDCD4 -
AS1 alleviates triple negative
breast cancer by increasing expression of
IQGAP2 via miR-10b-5p . -
pubmed
This study was designed to detect the influences and regulatory mechanism of lncRNA
PDCD4 -
AS1 in triple - negative
breast cancer (
TNBC ) . -
pubmed
METHODS : qRT - PCR and Western blot were utilized to investigate the expression levels of
PDCD4 - AS1 , miR-10b-5p and
IQGAP2 in
TNBC tissues and cells . -
pubmed
RESULTS : In this work ,
PDCD4 -
AS1 and
IQGAP2 were lowly expressed while miR-10b-5p was strongly expressed in
TNBC tissues and cells . -
pubmed
PDCD4 -
AS1 or
IQGAP2 overexpression effectively attenuated
TNBC cell proliferation , migration and invasion , and increased the apoptosis rate , while this effect was abandoned in response to miR-10b-5p mimics transfection . -
pubmed
CONCLUSION : Our findings identified lncRNA
PDCD4 - AS1 as a tumor suppressor in
TNBC by regulating
IQGAP2 expression via miR-10b-5p , giving a novel insight into the regulatory mechanism of
PDCD4 -
AS1 in the pathogenesis of
TNBC . -
pubmed
The findings suggest that alteration of the cell surface membrane and microfilaments prevents damage by interfering with cell - target interactions , that energy derived from glycolysis is required for
cytotoxicity , that cell - associated
esterases are probably involved , and that
cytotoxicity may be modulated by
cyclic nucleotides . -
pubmed
Favism in a Portuguese family due to a deficient
glucose - phosphate dehydrogenase variant ( Canton ) or ( cpanton - like ) type . -
pubmed
CA 125 levels in monitoring therapy for
endometriosis and in prediction of recurrence . -
pubmed
CA 125 levels were measured in the serum of 18
patients with laparoscopically diagnosed stage 2 to stage 4
endometriosis ( American Fertility Society classification ) and in eight normally cycling control
women . -
pubmed
The mean
CA 125 level in
women with
endometriosis was significantly higher than that observed in normal
women ( 28.6 + /- 5.1 ( + /- SE ) units / mL vs. 11.1 + /- 1.1 units / mL ) . -
pubmed
Four of the
patients who had recurrence of symptoms approximately 1 year after treatment had
CA 125 levels close to pretreatment levels , and recurrence of
endometriosis was confirmed by laparoscopy . -
pubmed
These results indicate that ( 1 )
CA 125 level can predict active
endometriosis lesions in
patients with stage 3 and stage 4
endometriosis , but is of no value for predicting adhesions ; ( 2 )
CA 125 levels are useful in monitoring therapy during treatment ; ( 3 ) during the follow - up period , elevations in
CA 125 might predict recurrence of disease in
women with stage 3 and stage 4
endometriosis.(ABSTRACT TRUNCATED AT 250 WORDS ) -
pubmed
As more has become known about the mechanisms by which abnormal levels of circulating lipoproteins promote
atherosclerosis , certain risk factors have emerged as concerns for women , including : ( 1 )
diabetes mellitus as a risk factor , perhaps through its more profound effects on circulating lipoproteins ; ( 2 ) serum
triglyceride levels , and ( 3 ) changes in
high - density lipoprotein cholesterol . -
pubmed
Although
human T cell surface glycoprotein CD4 is the cellular receptor for
human immunodeficiency virus 1 (
HIV-1 ) , the introduction of the
human CD4 gene into
murine cells does not render them susceptible to
HIV-1 infection . -
pubmed
HPRT gene mutations in a female
Lesch - Nyhan patient . -
pubmed
The value of
penicillinase sensitive
penicillins in treating superficial
wound infections is questioned . -
pubmed
[ Study of
growth hormone gene in
non - familial complete somatotropin deficiency ] . -
pubmed
On the basis of the results the neuroendocrine nature of this uncommon
neoplasm of the skin is confirmed and it is suggested that
chromogranin A could represent an additional marker for
Merkel cells tumors . -
pubmed
Administrations ( injections and in feed ) of
bromocriptine , a
dopamine agonist that inhibits
prolactin secretion , reduced body fat stores and plasma total
cholesterol and
triglyceride concentrations in several rodent species (
Syrian hamsters ,
Djungarian hamsters ,
Swiss Webster mice and
obese Zucker
rats ) . -
pubmed
These findings offer further evidence for a primary role of
prolactin in lipid metabolism and indicate that
bromocriptine may be useful for treating
obesity and lipid - based
cardiovascular disorders . -
pubmed
The available data from experimental and clinical studies suggest that in the development of
hypertension following correction of
renal anemia under
rhEPO three mechanisms are operative : ( 1 ) an increase in whole blood viscosity ; ( 2 ) possible also a reduction of hypoxic vasodilatation , and ( 3 ) at least in some patients an inadequate
reduction of cardiac output . -
pubmed
To avoid cardiovascular complications under
rhEPO therapy , the following should be considered :
Patients that were
hypertensive before the start of renal replacement therapy , even if they were normotensive in the
anemic state - because of morphological alterations of their peripheral vascular bed - may run a higher risk for developing
hypertension under
rhEPO . -
pubmed
Patients who are
hypertensive under
rhEPO therapy should be treated by antihypertensive drugs as appropriate . -
pubmed
Two
calcium - binding proteins in infiltrate macrophages of
rheumatoid arthritis . -
pubmed
In acutely inflamed tissues , macrophages can express
MRP-14 but not
MRP-8 , and in
chronic inflammations , such as
primary chronic polyarthritis , infiltrate macrophages express both
MRP-8 and
MRP-14 . -
pubmed
Characterization of
MRP-8 and
MRP-14 could therefore be useful to the understanding of cellular processes induced in
chronic inflammation . -
pubmed
The role of
fibronectin in the process of
wound healing . -
pubmed
Thus ,
hyperglycemia may exert an inhibitory effect on the plasma
GH response to hGHRH-44 . -
pubmed
The mechanisms by which elevated levels of
vasopressin (
ADH ) in
man and animals cause serious
myocardial dysfunction , evidenced by
arrhythmias , reduction in cardiac output and coronary blood flow , are not settled . -
pubmed
Fusion of the dominant negative transcription regulator
CHOP with a novel gene
FUS by translocation t(12;16 ) in
malignant liposarcoma . -
pubmed
We show that the translocation t(12;16)(q13 : p11 ) in
malignant myxoid liposarcoma can be a fusion of the
CHOP dominant negative transcription factor gene with a novel gene ,
FUS , which can result in fusion of the
FUS glycine - rich protein with the whole
CHOP coding region . -
pubmed
Correlation of magnetic resonance imaging features with
cytokine production by
tumor cells . -
pubmed
Immunohistochemistry was performed for immunophenotyping and for
cytokine expression by
tumor cells . -
pubmed
Immunohistochemical stains showed a B - cell phenotype for each
tumor and positive immunoreactivity in
tumor cells for
cytokine mediators that stimulate osteoclastic activation . -
pubmed
CONCLUSIONS : These findings indicate that the
tumor cells in these cases produce soluble
cytokine mediators that may regulate extensive osteoclastic activity . -
pubmed
To clarify the role of
serotonin , the in vivo and in vitro effects of the selective
5 - HT2 receptor antagonist ,
DV-7028 , on
MCT - induced
pulmonary hypertension were studied . -
pubmed
Regional adoptive immunotherapy with
interleukin-2 and lymphokine - activated killer ( LAK ) cells for
liver metastases . -
pubmed
Patients with
liver metastases received continuous high - dose infusion of
interleukin-2 (
IL-2 ) into the splenic artery or intravenous infusion with subsequent transfer of lymphokine - activated killer ( LAK ) cells into the portal vein or the hepatic artery . -
pubmed
The usual side - effects of
IL-2 and LAK cells occurred without limiting
liver toxicity . -
pubmed
Galaptin and
galaptin - binding glycoconjugates in serum and effusions of
carcinoma patients . -
pubmed
The objectives of this study were ( 1 ) to quantify
galaptin , an endogenous
lectin , and galaptin - binding glycoconjugates present in normal serum , ( 2 ) to determine if these components were altered in the serum and effusions of
carcinoma patients with advanced disease , and ( 3 ) to determine if
ovarian carcinoma cells synthesize and release soluble
galaptin inhibitors . -
pubmed
Galaptin levels in
carcinoma patient serum ( n = 29 ) were depressed ( mean 21 + /- 23 ng / ml ; p & lt ; 0.0001 ) . -
pubmed
Galaptin was not detected in 6 of 8 ovarian
carcinoma patient sera . -
pubmed
The data presented show that the levels of soluble
galaptin and galaptin - binding glycoconjugates in the serum of advanced
cancer patients are perturbed relative to normal female serum . -
pubmed
The unexpected observation that the increased T cells were mainly
CD4 may be related to the mild
GVHR and the clinical improvement . -
pubmed
Prognostic significance of 67 - kDa
laminin receptor expression in advanced
gastric cancer . -
pubmed
The ability of
cancer cells to attach to
laminin has been correlated with their metastatic potential and highly metastatic
cancer cells seem to express on their surface significantly more
laminin receptors than do their much less metastatic or benign counterparts . -
pubmed
The expression of
67 - kDa laminin receptors (
LR ) was investigated in a group of 75
patients who underwent gastrectomy for advanced
gastric cancer , with special reference to the possible role in the
tumor progression and in the overall survival . -
pubmed
The
tumor LR expression was immunohistochemically determined in paraffin - embedded sections using the
MLuC5 monoclonal antibody which recognizes the 67 - kDa
LR and the
avidin -
biotin immunoperoxidase method . -
pubmed
A significant association between
LR expression and depth of
tumor invasion ( 0.022 ) was found . -
pubmed
By univariate analysis the presence of
laminin receptors seemed to be associated with a higher risk of death [ RR 1.72 ( 95 % CI 0.71 - 4.20 ] , but this effect disappeared after controlling for depth of
tumor invasion . -
pubmed
In conclusion , these results suggest that
tumor expression of
laminin receptors could be correlated with
tumor aggressiveness . -
pubmed
However , the prognostic significance of
laminin receptor expression is already provided by the depth of
tumor invasion . -
pubmed
Structural analysis of the
C - CAM1 molecule for its
tumor suppression function in
human prostate cancer . -
pubmed
BACKGROUND : Recently , we demonstrated that expression of
C - CAM1 , an
immunoglobulin ( Ig )- like cell adhesion molecule (
CAM ) , was diminished in both
prostate intraepithelial neoplasia and
cancer lesions , indicating that loss of
C - CAM1 expression may be involved in the early events of prostate carcinogenesis . -
pubmed
Also , increased
C - CAM1 expression can effectively inhibit the growth of
prostate cancer . -
pubmed
In this study , we further analyzed the functional domain of
C - CAM1 for controlling its
tumor suppression function . -
pubmed
RESULTS : In vivo tumorigenic assay indicated that
AdCAMDeltaD1 without cell adhesion function still retained its
tumor suppression activity . -
pubmed
CONCLUSIONS : Our data indicate that the intracellular domain of the
C - CAM1 molecule is critical for inhibiting the growth of
prostate cancer , suggesting that
C - CAM1 interactive protein(s ) may dictate prostate carcinogenesis . -
pubmed
Granulocyte colony - stimulating factor -- primed allogeneic bone marrow transplants : capturing the advantages of blood stem cell transplants without increased risk of
chronic graft - versus - host disease . -
pubmed
MyoD1 and
myogenin expression in
human neoplasia : a review and update . -
pubmed
Terguride treatment attenuated
prolactin release and enhanced
insulin receptor affinity and
GLUT 4 content in obese spontaneously
hypertensive female , but not male
rats . -
pubmed
Glucose tolerance , serum
insulin ,
insulin receptors in epididymal fat tissue , and
GLUT 4 content in muscle , as well as
serum prolactin , were studied in obese and lean spontaneously
hypertensive rats ( SHRs ) of both sexes . -
pubmed
Obese animals displayed
insulin resistance and decreased capacity of high - affinity binding sites of
insulin receptors in fat tissue plasma membranes . -
pubmed
GLUT 4 content in musculus quadriceps was diminished only in
obese females . -
pubmed
Terguride treatment lowered
prolactin serum levels , which was concomitant with ameliorated
insulin sensitivity in
obese animals of both sexes . -
pubmed
Similarly , only in
obese females ,
terguride significantly increased the affinity of high - affinity
insulin - binding sites and normalized
GLUT 4 content . -
pubmed
Our results document downregulation of
insulin receptors and
GLUT 4 in
obesity and suggest a role for
prolactin in
obesity - induced
insulin resistance , particularly in female
rats . -
pubmed
Treatment of
cutaneous T cell lymphoma with extracorporeal photopheresis induces
Fas - ligand expression on treated T cells , but does not suppress the expression of
co - stimulatory molecules on monocytes . -
pubmed
Exposure to high concentrations of
glucose and
insulin results in
insulin resistance of metabolic target tissues , a characteristic feature of
type 2 diabetes . -
pubmed
In contrast to findings after long - term
hyperglycemia , there was no membrane translocation of novel isoforms of
protein kinase C in skeletal muscle after 6 h. These data support the concept that oxidative stress contributes to the pathogenesis of
hyperglycemia - induced
insulin resistance . -
pubmed
Current treatments of
human immunodeficiency virus type 1 ( HIV-1 ) infection consist in the combination of drugs targeting
reverse transcriptase (
RT ) and
protease (
PR ) . -
pubmed
Silibinin down - regulates
prostate epithelium - derived Ets transcription factor in
LNCaP prostate cancer cells . -
pubmed
The
androgen - sensitive
human prostate cancer cell line
LNCaP expresses the
estrogen receptor beta and
androgen receptor and can be stimulated by
androgens to secrete
prostate - specific antigen (
PSA ) . -
pubmed
In this study we demonstrate the
cancer protective potential of
silibinin , a
flavolignan derived from the fruits of
Silybum marianum , which down - regulates the co - activator of the
androgen receptor , the
prostate epithelium - derived Ets transcription factor (
PDEF ) and consequently the secretion of
PSA . -
pubmed
Our results indicate that , in contrast to
ATM ,
Chk2 activity is triggered by a greater number of DSBs , implying that , below a certain threshold level of
lesions ( & lt;19 DSBs ) , DNA repair can occur through
ATM , without enforcing
Chk2 - dependent checkpoints . -
pubmed
He was given the
gonadotropin - releasing hormone agonist
leuprolide acetate and the
androgen receptor antagonist
flutamide for the treatment of
prostate cancer . -
pubmed
After improvement of
hyperglycemia by
insulin treatment , their glycemic control remained good after treatment with
pioglitazone without use of
insulin . -
pubmed
Exposure of
tissue factor ( TF)-bearing cells to blood is the initial event in coagulation and intravascular
thrombus formation . -
pubmed
OBJECTIVES : The primary objective of the study was to evaluate the immunogenicity of a combined
hepatitis A and
hepatitis B vaccine compared to the effect of the administration of two monovalent
hepatitis A and B vaccines by quantitative measurements of the
anti - HBs antibody levels at month 2 of the vaccination course . -
pubmed
Seroprotection against
hepatitis B was defined as
anti - HBs antibody concentration & gt ; or = 10 IU / l , and longterm seroprotection as & gt ; or = 100 IU / l. RESULTS : In all , 288 subjects completed the study . -
pubmed
Erlotinib (
Tarceva ,
OSI-774 ; Pfizer , Inc. ) is an orally - active , targeted inhibitor of the
epidermal growth factor receptor (
EGFR /
HER1 ) , which is part of a key regulatory pathway in
cancer . -
pubmed
Negative impact of
human leukocyte antigen matching in the outcome of
polyomavirus nephropathy . -
pubmed
We correlated the number of matched
HLA - A ,
HLA - B , and
HLA - DR antigens with graft outcome in 90 patients with
PVAN . -
pubmed
Indeed , when transduced in
human colon carcinoma LoVo cells , a mutant
proPC1 incapable of cleaving off its prodomain was shown to accumulate in the nucleus . -
pubmed
Molecular aspects of
gefitinib antiproliferative and pro - apoptotic effects in
PTEN - positive and
PTEN - negative
prostate cancer cell lines . -
pubmed
One of the major targets for the therapy in
PCa can be
epidermal growth factor receptor (
EGFR ) , which signals via the
phosphoinositide 3 '- kinase (
PI3K)/
Akt and
mitogen - activated protein kinase (
MAPK ) pathways , among others . -
pubmed
Despite multiple reports of overexpression in
PCa , the reliance on activated
EGFR and its downstream signalling to the
PI3 K and/or
MAPK /
extracellular signal - regulated kinase (
ERK ) pathways has not been fully elucidated . -
pubmed
We reported that the
EGFR - selective
tyrosine kinase inhibitor
gefitinib (
ZD1839 ;
Iressa ) is able to induce growth inhibition , G(1 ) arrest and apoptosis in
PCa cells and that its effectiveness is associated primarily with
phosphatase and tensin homologue deleted from chromosome 10 (
PTEN ) expression ( and thus
Akt activity ) . -
pubmed
In fact
PTEN - negative
PCa cells are slowly sensitive to
gefitinib treatment , because this molecule is unable to downregulate
PI3K /
Akt activity . -
pubmed
The
MAPK pathway seems to be involved primarily on cell - growth modulation because dual blockade of
EGFR and
ERK1 / 2 phosphorylation potentiates growth inhibition ( both not cell apoptosis ) in
PTEN - positive
PCa cells and reduced
EGF - mediated growth in
PTEN - negative cells . -
pubmed
Therefore , our data suggest that the inhibition of
EGFR signalling can result in a significant growth reduction and in increased apoptosis in
EGFR - overexpressing
PCa cells with different modalities , which are regulated by
PTEN status , and this may have relevance in the clinical setting of
PCa . -
pubmed
Out of
diabetic mothers , only 19 ( 47.5 % ) were taking
insulin albeit irregularly . -
pubmed
Cathepsin K in adipocyte differentiation and its potential role in the pathogenesis of
obesity . -
pubmed
CTSK was up - regulated in the WAT of overweight /
obese subjects , and it had a significant positive correlation with body mass index . -
pubmed
CTSK may be involved in the pathogenesis of
obesity by promoting adipocyte differentiation . -
pubmed
This article describes the regulation of
human CD4 + T cell responses to
glutamic acid decarboxylase 65 (
GAD65 ) , an autoantigen implicated in
type-1 diabetes , by autologous CD8 + suppressor T cells . -
pubmed
In this study , we performed two - dimensional differentiation in - gel electrophoresis of
tumors treated with anti - mir-21 and identified the
tumor suppressor
tropomyosin 1 (
TPM1 ) as a potential mir-21 target . -
pubmed
Finally , overexpression of
TPM1 in
breast cancer MCF-7 cells suppressed anchorage - independent growth . -
pubmed
Thus , down - regulation of
TPM1 by mir-21 may explain , at least in part , why suppression of mir-21 can inhibit
tumor growth , further supporting the notion that mir-21 functions as an oncogene . -
pubmed
Angiotensin - converting enzyme gene polymorphism and
stroke in
type 2 diabetic patients in Taiwan . -
pubmed
BACKGROUND : The effect of traditional risk factors on the association between
angiotensin - converting enzyme (
ACE ) gene insertion / deletion ( I / D ) polymorphism and
stroke was rarely studied previously . -
pubmed
CONCLUSION : Traditional risk factors play an important role in the association between the
ACE genotypes and
stroke . -
pubmed
Tumor immune escape mediated by
indoleamine 2,3 - dioxygenase . -
pubmed
Amongst the numerous mediators contributing towards the escape of
tumors from the host 's immune response against them , the enzyme
indoleamine 2,3 - dioxygenase (
IDO ) has recently attracted special attention . -
pubmed
The recent identification of
IDO - expressing
tumor cells has implicated this molecule as a key mediator of the
tumor immune escape . -
pubmed
Mounting evidence indicates that , within the
tumor microenvironment , not only
tumor cells but also other infiltrating cells such as dendritic cells , monocytes and others can be sources of
IDO . -
pubmed
IDO - induced
tryptophan depletion from the
tumor microenvironment could be the result of either elevated levels of the enzyme or augmented
tryptophan consumption by both
tumor cells and antigen presenting cells of the host . -
pubmed
Finally , evidence emerges indicating that
IDO possibly promotes
tumor immune escape by inducing an immunoregulatory or an anergic T cell phenotype at a systemic level . -
pubmed
BACKGROUND : Little research has explored the association of macronutrient intake and
glycated hemoglobin (
HbA ( 1c ) ) in adults with
diabetes . -
pubmed
BACKGROUND : Initiation of an
atherosclerotic lesion requires endothelial expression of
adhesion molecules . -
pubmed
This is at least partially caused by
hyperglycemia and
hyperinsulinemia increasing
adhesion molecule expression . -
pubmed
The
endothelin - converting enzyme-1 /
endothelin-1 pathway plays a critical role in
inflammation - associated premature delivery in a
mouse model . -
pubmed
Furthermore , we have previously shown that both the
endothelin - converting enzyme-1 (
ECE-1 ) inhibitor ,
phosphoramidon , as well as a novel
ET-1 receptor A antagonist synthesized by our group , control premature delivery in a
mouse model of
inflammation - associated preterm delivery . -
pubmed
Taken together , these data support a critical role for the
ECE-1 /
ET-1 system in
inflammation - associated premature delivery . -
pubmed
We used the combined
dexamethasone suppression /
CRH stimulation (
Dex - CRH ) test to evaluate the degree of HPA - axis dysregulation in 194 in -
patients with
unipolar depression from the Munich Antidepressant Response Signature ( MARS ) study at both admission and discharge . -
pubmed
Vascular endothelial growth factor and its receptor may be one molecular mechanism for
androgenetic alopecia . -
pubmed
Braf(V600E ) cooperates with
Pten loss to induce
metastatic melanoma . -
pubmed
Mutational activation of
BRAF is the earliest and most common genetic alteration in
human melanoma . -
pubmed
To build a model of
human melanoma , we generated
mice with conditional melanocyte - specific expression of
BRaf(V600E ) . -
pubmed
Upon induction of
BRaf(V600E ) expression ,
mice developed benign
melanocytic hyperplasias that failed to progress to
melanoma over 15 - 20 months . -
pubmed
By contrast , expression of
BRaf(V600E ) combined with
Pten tumor suppressor gene silencing elicited development of
melanoma with 100 % penetrance , short latency and with metastases observed in lymph nodes and lungs . -
pubmed
Melanoma was prevented by inhibitors of
mTorc1 (
rapamycin ) or
MEK1 / 2 (
PD325901 ) but , upon cessation of drug administration ,
mice developed
melanoma , indicating the presence of long - lived
melanoma - initiating cells in this system . -
pubmed
The present study therefore aimed to detect main effects as well as interactions of serotonergic candidate genes ( coding for the
serotonin transporter ,
5 - HTT ; the
serotonin autoreceptor ,
HTR1A ; and the enzyme which synthesizes
serotonin in the brain ,
TPH2 ) with the burden of life events ( # LE ) in two independent samples consisting of 183
patients suffering from
personality disorders and 123
patients suffering from adult
attention deficit / hyperactivity disorder (
aADHD ) . -
pubmed
Only the G allele of
HTR1A rs6295 seemed to increase the risk of emotional - dramatic cluster B
personality disorders ( p = 0.019 , in the
personality disorder sample ) and to decrease the risk of
anxious - fearful cluster C personality disorders ( p = 0.016 , in the
aADHD sample ) . -
pubmed
By doing so , we observed nominal evidence for G x E effects as well as main effects of 5 - HTT - LPR and the
TPH2 SNP rs4570625 on the occurrence of
personality disorders . -
pubmed
Osteopontin is a secreted ,
integrin - binding and phosphorylated acidic glycoprotein , which has an important role in
tumour progression . -
pubmed
We have shown that
Wnt ,
Ets ,
AP-1 ,
c - jun and
beta - catenin /
Lef-1 /
Tcf-1 stimulates
OPN transcription in
rat mammary carcinoma cells by binding to a specific promoter sequence . -
pubmed
RESULT :
MTS assay results showed the enhanced
cytotoxicity of anticancer drugs (
Oxaliplatin ,
Doxorubicin and
Etopside ) to the
H460 cell line with
keap1 overexpression compared to the control cell line . -
pubmed
Down - regulation of
Nrf2 enhanced the
cytotoxicity of
Oxaliplatin ,
Doxorubicin and
Etopside . -
pubmed
Down - regulation of
Nrf2 enhanced the
cytotoxicity of
Oxaliplatin ,
Doxorubicin and
Etopside . -
pubmed
Identification and analysis of a
Sciaenops ocellatus ISG15 homologue that is involved in host immune defense against
bacterial infection . -
pubmed
ISG15 homologues have been identified in a number of fish species , some of which are known to be regulated at expression level by
virus infection and lipopolysaccharide ( LPS ) treatment . -
pubmed
However , the relationship between
ISG15 and live
bacterial infection has not been investigated in piscine models . -
pubmed
Taken together , the results of this study indicated that
SoISG15 possesses apparent immunological property and is likely to be involved in host immune defense against
bacterial infection . -
pubmed
Platelet - derived growth factor (
PDGF ) functions as a chemotactic factor for dermal fibroblasts and plays an important role in the progression of
melanoma . -
pubmed
American Society of Clinical Oncology / College of American Pathologists guideline recommendations for immunohistochemical testing of
estrogen and progesterone receptors in
breast cancer . -
pubmed
PURPOSE : To develop a guideline to improve the accuracy of immunohistochemical ( IHC )
estrogen receptor (
ER ) and
progesterone receptor (
PgR ) testing in
breast cancer and the utility of these receptors as predictive markers . -
pubmed
RECOMMENDATIONS : The Panel recommends that
ER and
PgR status be determined on all invasive
breast cancers and
breast cancer recurrences . -
pubmed
It is recommended that
ER and
PgR assays be considered positive if there are at least 1 % positive
tumor nuclei in the sample on testing in the presence of expected reactivity of internal (
normal epithelial elements ) and external controls . -
pubmed
Exercise training reduces
insulin resistance and upregulates the
mTOR /
p70S6k pathway in cardiac muscle of diet - induced
obesity rats . -
pubmed
Acting through the
Akt /
mTOR pathway ,
insulin has numerous and important physiological functions , such as the induction of growth and survival of many cell types and
cardiac hypertrophy . -
pubmed
However ,
obesity and
insulin resistance can alter
mTOR /
p70S6k . -
pubmed
To evaluate the effect of exercise training on
mTOR /
p70S6k in the heart of
obese Wistar rats , we analyzed the effects of 12 weeks of swimming on
obese rats , induced by a high - fat diet . -
pubmed
Toll - like receptor 2 and
poly ( ADP - ribose ) polymerase 1 promote central nervous system neuroinflammation in progressive
EAE . -
pubmed
The algorithm proposed here could result in a suitable approach for faster and more effective identification of hit and/or lead compounds with
tyrosinase inhibitory activity , helping to shorten the long pipeline in the research of novel depigmenting agents to treat
skin disorders . -
pubmed
In vitro and in vivo evaluation of
64Cu - radiolabeled KCCYSL peptides for targeting
epidermal growth factor receptor-2 in
breast carcinomas . -
pubmed
Epidermal growth factor receptor-2 (
EGFR-2 ) has been implicated in the pathogenesis of
breast and other carcinomas . -
pubmed
In this report , we tested the ability of a bacteriophage selected peptide KCCYSL , radiolabeled with
64Cu , to image
EGFR-2 expressing
breast tumors in vivo by positron emission tomography ( PET ) . -
pubmed
The optimization of bifunctional chelators improves the pharmacokinetic properties of the
64Cu - labeled GSG - KCCYSL peptide , which enables the selection of a suitable peptide homolog as a PET imaging agent for
EGFR-2 expressing
breast carcinomas . -
pubmed
The NICE guidelines state that general practitioners should measure serum
CA125 in women presenting with persistent and continuous symptoms suggestive of
ovarian cancer ( e.g. -
pubmed
Sensitization of
tumor cells by targeting
histone deacetylases . -
pubmed
On the basis of their pro - apoptotic activity ,
HDAC inhibitors have been combined with conventional antitumor agents or novel target - specific agents to increase susceptibility to apoptosis and drug sensitivity of
cancer cells . -
pubmed
Overexpression of
matrix metalloproteinases (
MMPs ) and other proteases by
tumor cells allows intravasation of
tumor cells into the circulatory system after degrading the basement membrane and ECM ( 9 ) . -
pubmed
Elevated levels of
MMPs have been found in
tumors associated with a poor prognosis for
cancer patients ( 13 ) . -
pubmed
MMP2 is one of the major enzymes involved in the remodeling of the left ventricle after
ischemia and reperfusion ( I / R ) in the heart ( 14 ) . -
pubmed
A
connexin40 mutation associated with a malignant variant of progressive
familial heart block type I. -
pubmed
This is the first demonstration of a germ line mutation in a
connexin gene that associates with
inherited ventricular arrhythmias and emphasizes the importance of
Cx40 in normal propagation in the specialized conduction system . -
pubmed
Frequent activating
GNAS mutations in
villous adenoma of the colorectum . -
pubmed
To elucidate the role of
GNAS mutations in colorectal tumourigenesis , we performed a mutation analysis in a total of 234 colorectal
tumours , including
adenomas , serrated
lesions and
adenocarcinomas . -
pubmed
Activating
GNAS mutations were found in 20 of the 24 villous
adenomas ( 83 % ) but were absent in all the other
tumours , except for one tubulovillous
adenoma ( 3 % ) and two
adenocarcinomas ( 3 % ) . -
pubmed
KRAS mutations were frequent in villous ( 67 % ) and tubulovillous ( 60 % )
adenomas but were rare or absent in tubular
adenomas ( 6 % ) and serrated
lesions , including
hyperplastic polyps , sessile serrated
polyps / sessile serrated
lesions and traditional serrated
adenomas ( 0 - 9 % ) . -
pubmed
BRAF mutations were found in four villous
adenomas ( 17 % ) and in the large majority of serrated
lesions ( 81 - 92 % ) , but were absent in tubular and tubulovillous
adenomas . -
pubmed
Seventeen villous
adenomas ( 71 % ) harboured
GNAS mutations concomitantly with
KRAS or
BRAF mutations . -
pubmed
Immunohistochemically , all the villous
adenomas retained
mismatch repair protein expression , suggesting that they are
microsatellite - stable . -
pubmed
The current study showed that the presence of activating
GNAS mutations , in association with
KRAS or
BRAF mutations , is a characteristic genetic feature of
colorectal villous adenoma . -
pubmed
In the present study we attempted to elucidate the mechanisms of
glomerular injury induced by
FK506 and the renoprotective effects of the
angiotensin II receptor blocker
telmisartan . -
pubmed
CONCLUSION : These findings suggest that
glomerular injury resulting from
FK506 is caused by oxidative stress mediated by activation of
NAD ( P ) H oxidase and that
telmisartan exerts a renoprotective effect via antioxidative activity . -
pubmed
The
42 - mer amyloid beta - protein (
Abeta42 ) aggregates to form soluble oligomers that cause
memory loss and synaptotoxicity in
Alzheimer ' s disease (
AD ) . -
pubmed
We previously identified the toxic conformer of Abeta42 with a turn at positions 22 and 23 ( " toxic turn " ) by solid - state NMR and demonstrated that a monoclonal antibody (
11A1 ) against the toxic turn in
Abeta42 mainly detected the oligomer in the brains of
AD patients . -
pubmed
Our recent study suggested that oxidative stress is a key factor of the oligomerization and
cognitive impairment induced by
Abeta overproduction in vivo . -
pubmed
E22P - Abeta42 , but not
E22V - Abeta42 , induced greater ROS production than Wt - Abeta42 in addition to potent
neurotoxicity . -
pubmed
Interestingly , the formation of the toxic conformer in both E22P - Abeta42 and Wt -
Abeta42 probed by the
11A1 antibody preceded
Abeta42 - induced
neurotoxicity . -
pubmed
A peripheral blood cytogenetic analysis is performed due to a high suspicion of
leukemia , and the results show
BCR /
ABL fusion gene with a cut point in the M -
BCR region , which confirms the diagnosis of
chronic myeloid leukemia . -
pubmed
Neu2000 (
NEU ;
2 - hydroxy-5 -( 2,3,5,6 - tetrafluoro-4 - trifluoromethyl - benzylamino )- benzoic acid ) , a recently developed derivative of
acetylsalicylic acid and
sulfasalazine , potently protects against neuronal cell death following
ischemic brain injury by antagonizing
NMDA receptor - mediated
neuronal toxicity and oxidative stress . -
pubmed
These results suggest that
NEU attenuates
hypoxia - induced impairment of neuronal activity more potently than the antioxidant ,
trolox , and the
NMDA receptor antagonists ,
ifenprodil and
APV . -
pubmed
Deficiency of the
myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter - induced
gastric malignancy . -
pubmed
The role of
MyD88 in Helicobacter - induced
gastric malignancy is unknown . -
pubmed
Using a
mouse model of Helicobacter - induced
gastric cancer , we assessed the role of
MyD88 in
cancer development by evaluating gastric histopathology , apoptosis , proliferation , and
cytokine expression . -
pubmed
The progression of Helicobacter - induced disease to precancerous and
cancerous lesions in the absence of
MyD88 signaling was accompanied by increased gastric epithelial apoptosis and proliferation . -
pubmed
In addition , inflammatory
cytokines , including
tumor necrosis factor alpha (
TNF - alpha ) ,
gamma interferon (
IFN - gamma ) ,
IL-6 , and
IL-1beta were highly expressed in association with the development of
gastric dysplasia . -
pubmed
These data suggest that
MyD88 signaling retards development and progression to
cancer during
Helicobacter infection . -
pubmed
This is the first study to show evidence of
MyD88 protection in an
infection - driven inflammation - associated cancer model . -
pubmed
A key feature of
Parkinson disease is the aggregation of
alpha - synuclein and its intracellular deposition in fibrillar form . -
pubmed
COX-2 gene expression is correlated with cognitive function in recurrent
depressive disorder . -
pubmed
Cyclooxygenase-2(
COX-2 ) may be a key inflammatory enzyme involved in recurrent
depressive disorder(
rDD ) . -
pubmed
In
rDD group ,
COX-2 expression were higher and significant correlations occurred between
COX-2 expression and cognitive functions . -
pubmed
Thus , the
COX-2 enzyme may be important for cognitive functioning in
rDD . -
pubmed
These clinical implications entail that
CgA and its derived peptides are now used as diagnostic and prognostic markers or to monitor the response to pharmacological intervention not only in
endocrine tumors , but also in cardiovascular , inflammatory , and
neuropsychiatric diseases . -
pubmed
PELP1 - depleted
p53 ( wild - type )
breast cancer cells were less sensitive to various genotoxic agents including
etoposide ,
camptothecin or gamma - radiation . -
pubmed
Overall , these studies established a new role of
PELP1 in DDRs and these findings will have future implications in our understanding of
PELP1 's role in
cancer progression . -
pubmed
Finally , intravenous injection of the probe after
cerebral ischemia revealed activation of
caspase-3 in the infarcted hemisphere . -
pubmed
METHODS :
Tumor free ( n = 37 ) and metastatic ( n = 17 ) lymph nodes of T1 and T2
oscc patients were processed for immunohistochemistry to detect
CD68 ,
CD11c ,
CD163 and
MRC1 positive cells . -
pubmed
In platelet - rich plasma ( PRP ) therapy , various growth factors and
cytokines released the alpha - granules contained in platelets after activation can potentially enhance
wound healing by delivering . -
pubmed
In the longitudinal follow - up , each additional year of vegan diet lowered the risk of
obesity by 7 % ( 95 % CI 0 88 , 0 99 ) , whereas each additional year of lacto - vegetarian diet lowered the risk of elevated SBP by 8 % ( 95 % CI 0 85 , 0 99 ) and elevated
glucose by 7 % ( 95 % CI 0 87 , 0 99 ) , and each additional year of ovo - lacto - vegetarian diet increased abnormal
HDL by 7 % ( 95 % CI 1 03 , 1 12 ) , compared with non - vegetarians . -
pubmed
MATERIAL AND METHODS : 181
people were examined for the presence of
anti - A. phagocytophilum IgG antibodies ; 113 were
patients with suspected
TBE ( 65
males , 48 females ) , and 68 from the control group ( 18
males , 50 females ) . -
pubmed
OBJECTIVE : To characterize the clinical features and MRI abnormalities of
leucine - rich glioma - inactivated 1 (
LGI1)-autoantibody ( Ab )
faciobrachial dystonic seizures (
FBDS ) . -
pubmed
METHODS : Forty - eight
patients with
LGI1 - Ab
encephalopathy were retrospectively identified by searching our clinical and serologic database from January 1 , 2002 , to June 1 , 2015 . -
pubmed
Of these , 26 met inclusion criteria for this case series :
LGI1 - Ab seropositivity and
FBDS . -
pubmed
A separate analysis of all 48
patients initially identified with
LGI1 - Ab
encephalopathy showed that basal ganglia MRI abnormalities were present in 11 of 26 with
FBDS but not present in those without
FBDS ( 0/22 ) ( p & lt ; 0.001 ) . -
pubmed
CONCLUSIONS : Basal ganglia T1 hyperintensity is a clinically useful MRI biomarker of
LGI1 - Ab
FBDS and suggests a basal ganglia localization . -
pubmed
Evaluation of the
gingival inflammation in pregnancy and postpartum via
25 - hydroxy - vitamin D3 ,
prostaglandin E2 and
TNF - alpha levels in saliva . -
pubmed
In the pregnant healthy ,
gingivitis and
periodontitis groups saliva
TNF - alpha levels were significantly lower than postpartum and control counterparts ( p<0.0001 , p=0.032 , p=0.003 and p=0.013 ; p=0.027 ; p=0.007 , respectively ) . -
pubmed
The unexpected positive staining for
PAX-2 ,
PAX-8 and
CD10 in
renal hemangioblastoma needs to be aware . -
pubmed
Stem cells enhance neurogenesis and
Abeta clearing as well as improved
cognitive impairment . -
pubmed
We investigated whether
RA patients in long - term remission are characterized by normalized inflammatory activity of the arterial wall and if this is dependent on type of medication used (
TNF - inhibitor versus nonbiological disease - modifying antirheumatic drugs ( DMARDs ) ) . -
pubmed
However ,
RA subjects using current anti -
TNF therapy ( n = 13 , disease activity score 1.98[1.8 - 2.2 ] ) have an almost 1.2 - fold higher
( 18 ) F - FDG uptake in the arterial wall compared to those using DMARDs ( but with previous anti -
TNF therapy ) ( n = 10 , disease activity score 2.24[1.3 - 2.5 ] ) , which seemed to be predominantly explained by longer duration of their
rheumatic disease in a multivariate linear regression analysis . -
pubmed
Finally , we found increased activity in bone marrow and spleen in
RA patients using anti -
TNF therapy compared to those with DMARDs and controls . -
pubmed
CONCLUSIONS : A subset of
patients with
RA in clinical remission have activated monocytes and increased
inflammation in the arterial wall , despite the use of potent
TNF blocking therapies . -
pubmed
Comprehensive Profiling of the
Androgen Receptor in Liquid Biopsies from Castration - resistant
Prostate Cancer Reveals Novel
Intra - AR Structural Variation and Splice Variant Expression Patterns . -
pubmed
BACKGROUND : Expression of the
androgen receptor splice variant 7 (
AR - V7 ) is associated with poor response to second - line endocrine therapy in
castration - resistant prostate cancer (
CRPC ) . -
pubmed
We performed profiling of circulating
tumour DNA via low - pass whole - genome sequencing and targeted sequencing of the entire
AR gene , including introns . -
pubmed
Targeted RNA sequencing was performed on enriched circulating
tumour cell fractions to assess the expression levels of seven
AR splice variants ( ARVs ) . -
pubmed
Six out of 17 poor responders were
AR - V7 - negative , but four carried other
AR perturbations . -
pubmed
CONCLUSION :
CEA can be performed safely in
patients receiving dialysis , but further operative procedures and careful postoperative management are likely to be needed for
patients with
CEA who are receiving dialysis . -
pubmed
The dose - dependent negative effect of transfusions was also found in favorable subgroups ( pT1
tumor ,
hemoglobin & gt;=13 mg / dl , p = .004 ) and in a high - volume surgeon subgroup ( n = 244 , p & lt ; .001 ) . -
pubmed
Study outcomes included the incidence of
bladder perforation and
obturator jerk , decrease in
hemoglobin and
sodium levels , rates of re - coagulation and blood transfusion , TUR syndrome , and operation time . -
pubmed
Mucin 5B in saliva and serum of
patients with
oral lichen planus . -
pubmed
This study aimed to assess the level of
Mucin 5B in
OLP patients with
xerostomia . -
pubmed
Level of
Mucin 5B in unstimulated saliva was significantly lower in
OLP group ( P = 0.0001 ) while it was not significantly different in stimulated saliva of the two groups ( P & gt ; 0.05 ) . -
pubmed
Level of
Mucin 5B was significantly higher in serum of
OLP patients ( P = 0.016 ) . -
pubmed
Both saliva flow and level of
Mucin 5B decrease in
OLP patients . -
pubmed
Since
Mucin 5B is effective for wetting and lubrication of the oral cavity , this result can suggest a possible reason for
mouth dryness in
OLP patients . -
pubmed
It is not known exactly where
amyloid - beta (
Abeta ) fibrils begin to accumulate in
individuals with
Alzheimer ' s disease (
AD ) . -
pubmed
Recently , we showed that abnormal levels of
Abeta42 in cerebrospinal fluid ( CSF ) can be detected before abnormal amyloid can be detected using PET in
individuals with preclinical
AD . -
pubmed
The earliest
Abeta accumulation is further associated with hypoconnectivity within the DMN and between the DMN and the frontoparietal network , but not with
brain atrophy or
glucose hypometabolism . -
pubmed
Our results suggest that
Abeta fibrils start to accumulate predominantly within certain parts of the DMN in preclinical
AD and already then affect brain connectivity . -
pubmed
CONCLUSION : According to the present findings , it can be concluded that the intraurethral administration of LPS promotes tissue remodeling , as well as stimulating the pattern of pro - inflammatory
cytokines , and therefore , constitutes an effective experimental model of
BPH /
inflammation . -
pubmed
CONCLUSIONS : Modest
weight loss in postmenopausal
women has a lowering effect on
leptin concentrations over 24 months which may improve inflammatory status whilst modest weight gain increases
ICAM-1 ,
leptin and
TNF - alpha , markers which are associated with a pro - inflammatory state and
vascular complications . -
pubmed
Substitutions of
PrP N - terminal
histidine residues modulate
scrapie disease pathogenesis and incubation time in transgenic
mice . -
pubmed
Novel transgenic
mice expressing
PrP(TetraH > G ) at levels comparable to wild - type ( wt ) controls were susceptible to
mouse - adapted
scrapie strain RML but showed significantly prolonged incubation times . -
pubmed
High
BCAR1 expression is associated with early
PSA recurrence in
ERG negative
prostate cancer . -
pubmed
BACKGROUND :
Breast cancer anti - estrogen resistance 1 (
BCAR1 /
p130cas ) is a hub for diverse oncogenic signaling cascades and promotes
tumor development and progression . -
pubmed
METHODS : To understand the effect of
BCAR1 in
prostate cancer , we analyzed its expression on more than 11,000
prostate cancer samples . -
pubmed
RESULTS :
BCAR1 staining was barely detectable in
normal prostate glands but seen in 77.6 % of 9472 interpretable
cancers , including strong expression in 38.5 % , moderate in 23.2 % and weak in 15.9 % of cases . -
pubmed
BCAR1 up regulation was associated with
positive ERG status ( p & lt ; 0.0001 ) , high Gleason score ( p & lt ; 0.0001 ) , advanced pathological
tumor stage ( p = 0.0082 ) , lower preoperative
PSA level ( p & lt ; 0.0001 ) , increased cell proliferation ( p & lt ; 0.0001 ) , early
PSA recurrence ( p = 0.0008 ) , and predicted prognosis independently from clinico - pathological parameters available at the time of the initial biopsy . -
pubmed
However , subset analyses revealed that the prognostic impact of
BCAR1 expression was limited to
ERG - negative
cancer . -
pubmed
CONCLUSION : The results of our study identify
BCAR1 as a prognostic biomarker with potential clinical value for risk stratification of
ERG - negative prostate cancer . -
pubmed
2 - aminopurine suppresses the
TGF - beta1 - induced epithelial - mesenchymal transition and attenuates
bleomycin - induced
pulmonary fibrosis . -
pubmed
Idiopathic pulmonary fibrosis (
IPF ) is a progressive and fatal disease characterized by fibroblast accumulation and
collagen deposition in the lungs . -
pubmed
Collectively , we determined that 2 - AP could inhibit metastasis in vitro by suppressing the
TGF - beta1 - induced EMT and could attenuate
BLM - induced
pulmonary fibrosis in vivo . -
pubmed
However , it has been reported that many cellular activators , including
vascular endothelial growth factor (
VEGF ) , are produced by
tumor cells after PDT . -
pubmed
We evaluated the efficacy of bevacizumab - based anti - angiogenesis in combination with PDT as well as the resulting
VEGF levels and microvessel density ( MVD ) in a
mouse model of
human colon cancer . -
pubmed
Enzyme - linked immunosorbent assay ( ELISA ) and immunohistochemistry ( IHC ) were performed to assess
VEGF concentrations and microvessel density in the various treatment groups , and confocal imaging and high performance liquid chromatography ( HPLC ) analyses were used to measure the distribution and concentration of
mTHPC in
tumors . -
pubmed
Immunostaining and ELISA analyses revealed a lower expression of
VEGF in
tumors treated with combination therapy of PDT followed by bevacizumab . -
pubmed
In the case of
Ebola virus , for example , the discovery of the lysosomal protein
NPC1 as an intracellular receptor sparked the development of tailored strategies to interfere with viral infection . -
pubmed
HIF-1alpha drives cyst growth in advanced stages of
autosomal dominant polycystic kidney disease . -
pubmed
However , the functional impact of
HIF-1alpha in
cystic kidney disease was unknown . -
pubmed
A new study has shown that
HIF-1alpha promotes cyst progression in a
mouse model of
autosomal - dominant polycystic kidney disease . -
pubmed
CD44 splice isoform switching determines
breast cancer stem cell state . -
pubmed
Here we report that splice isoforms of the
cancer stem cell ( CSC ) marker
CD44 exhibit strikingly opposite functions in
breast cancer . -
pubmed
Bioinformatic annotation in patient
breast cancer in The Cancer Genome Atlas ( TCGA ) database reveals that the
CD44 standard splice isoform (
CD44s ) positively associates with the
CSC gene signatures , whereas the
CD44 variant splice isoforms (
CD44v ) exhibit an inverse association . -
pubmed
These results reveal
CD44 isoform specificity in
CSC and non - CSC states and suggest that alternative splicing provides functional gene versatility that is essential for distinct
cancer cell states and thus
cancer phenotypes . -
pubmed
We evaluated the
histamine 's role in regulating the iris vasomotricity in
rats , using as a research tool topical
olopatadine , a selective
H1 blocker , which is indicated for the treatment of
allergic conjunctivitis and
ranitidine , a selective
H2 blocker mainly used for the treatment of
peptic ulcer disease . -
pubmed
Olopatadine , a topical
H1 antagonist used in the treatment of
ocular allergies , may interfere with the humoral regulation of the iris arteriolar tone . -
pubmed
Contribution of
Matrix Metalloproteinase-2 Promoter Genotypes to
Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan . -
pubmed
BACKGROUND / AIM :
Matrix metalloproteinase 2 (
MMP2 ) is up - regulated in many
cancers . -
pubmed
However , the association of
MMP2 genotype to
nasopharyngeal cancer (
NPC ) susceptibility in Taiwan remains elusive . -
pubmed
MATERIALS AND METHODS : In this study , the role of
MMP2 promoter C-1306 T ( rs243865 ) and C-735 T ( rs2285053 ) genotypes were investigated among 208
NPC patients and 416 healthy controls , and their role in
NPC staging and TNM classifications were examined . -
pubmed
CONCLUSION : CT and TT genotypes at
MMP2 C-1306 T were associated with a significantly decreased risk of
NPC metastasis . -
pubmed
In the patient group , correlation and adjustment analyses showed associations of OST with various disease activity markers [ DAS28 ( rho=0.313 ) , swollen joint counts ( rho=0.361 ) ,
CRP ( rho=0.389 ) ; all , padj=0.001 ) ] , age ( rho=0.276 , p<0.001 ) and
osteoarthritis ( p=0.022 ) . -
pubmed
Finally , we showed that
ZIKV - infected
mouse models displayed similar
CAM upregulation and that soluble
CAMs were increased in plasma samples from
ZIKV - infected patients . -
pubmed
The
Rho guanine nucleotide exchange factor (
RGNEF ) protein encoded by the
ARHGEF28 gene has been implicated in the
neurodegenerative disease amyotrophic lateral sclerosis (
ALS ) . -
pubmed
Biochemical and pathological studies have shown that
RGNEF is a component of the hallmark neuronal cytoplasmic inclusions in
ALS - affected neurons . -
pubmed
Additionally , a heterozygous mutation in
ARHGEF28 has been identified in a number of
familial ALS (
fALS ) cases that may give rise to one of two truncated variants of the protein . -
pubmed
Little is known about the normal biological function of
RGNEF or how it contributes to
ALS pathogenesis . -
pubmed
Additionally , through unbiased screening using the split -
ubiquitin system , we have identified
RGNEF - interacting proteins , including two
ALS - associated proteins . -
pubmed
Our findings indicate that
RGNEF misfolding and toxicity may cause impairment of the microtubule network and contribute to
ALS pathogenesis . -
pubmed
Protective effect of
proton pump inhibitors and
potassium competitive acid blockers against post - gastric endoscopic submucosal dissection
bleeding : a single - center , propensity score - matched analysis . -
pubmed
We examined the cross - sectional relationship between serum levels of 8 pro - inflammatory markers (
IL-1beta ,
IL-6 ,
TNF - alpha ,
IL-8 ,
MCP-1 ,
CXCL10 ,
IL-12p70 ,
CRP ) and performance on a detailed neuropsychological assessment battery in middle - aged
adults with uncomplicated
T2DM ( N = 89 ; 52 + - 8.1 years , 47 % female ) and matched healthy controls ( N = 50 ; 52 + - 8.3 years , 59 % female ) . -
pubmed
We observed a significant
T2DM - specific association between serum
TNF - alpha levels and scores on the Paired Associates Learning ( PAL ) task ( beta : -3.16 , SE : 1.32 , p = 0.01 , Std . -
pubmed
We provide exploratory evidence for a significant
T2DM - specific relationship between serum
TNF - alpha and memory performance . -
pubmed
Role of
mixed - function oxidase in
3 - methylindole - induced
acute pulmonary edema in
goats . -
pubmed
The relationship between the
pulmonary toxicity of
3 - methylindole (
3MI ,
skatole ) and the
mixed - function oxidase (
MFO ) system was investigated . -
pubmed
Results indicate that the
MFO system is one of the pathways involved in the metabolism of
3MI and that
pulmonary toxicosis results from metabolism of
3MI by this
enzyme system . -
pubmed
The anti - melanoma monoclonal antibody
HMB45 is widely used in diagnostic pathology owing to its great specificity and sensitivity in identifying
pigmented tumors such as
malignant melanoma . -
pubmed
Thus ,
HMB45 may identify an oncofetal antigen present in cutaneous melanocytes , RPE , and
melanoma cells , and changes in immunoreactivity with maturation or malignant transformation may be a function of post - translational modification . -
pubmed
An evaluation of
ovarian carcinoma - associated antigen defined by
murine monoclonal antibody CF511 in sera from
patients with
ovarian carcinoma . -
pubmed
Murine monoclonal antibody
CF511 , raised against
human ovarian clear cell carcinoma , detects a glycoprotein ( Mr 600 kDa ) called
CF511 antigen which is elevated in the serum of many
patients with
ovarian carcinoma . -
pubmed
A competitive enzyme - linked immunosorbent assay was developed to detect
CF511 antigen in
human serum and used to detected
CF511 antigen in
subjects with
ovarian carcinoma and other diseases . -
pubmed
Raised serum levels of
CF511 antigen were found in 6/46
patients ( 13.0 % ) with benign gynaecological
tumours ( including
endometriosis or
ovarian cyst ) , in 5/7
patients ( 71.4 % ) with
breast carcinoma and 16/21 ( 76.2 % ) lung
carcinoma patients . -
pubmed
Determination of
CF511 antigen levels may be useful for detection of
ovarian carcinoma as well as lung and
breast carcinomas and for monitoring progress of disease and response to therapy . -
pubmed
[
HLA antigens in
diffuse toxic goiter ] . -
pubmed
The paper is concerned with some data of investigation of the association of the
HLA - system with the development of
diffuse toxic goiter (
DTG ) . -
pubmed
Comparative analysis of the distribution of
HLA - antigens was performed in 50
patients with various degrees of DTG severity , different therapeutic methods ( operative and conservative ) and outcomes of disease ( postoperative
hypothyrosis , DTG recurrence and
euthyroid condition ) . -
pubmed
Basic fibroblast growth factor in
human pituitary tumours . -
pubmed
Immunoreactive (
ir )
basic fibroblast growth factor (
FGF ) has been measured in normal
human pituitary glands and in 41
pituitary tumours of various types using a radioimmunoassay . -
pubmed
Normal pituitary glands contained ir basic
FGF ranging from 29.4 to 355 fmol / mg wet weight whereas 87.5 % of
pituitary tumours contained amounts of the
growth factor which were less than normal . -
pubmed
There was no relationship between the type of
tumour and the
FGF content . -
pubmed
Because of our previous observation that
basic FGF inhibits the growth of
human pituitary tumour cells , it is suggested that the reduction in
basic FGF of many
pituitary tumours may favour the stimulation of pituitary growth . -
pubmed
Reciprocal interference between
milk - transmitted mammary tumor virus and
Friend leukemia viruses in
mice : possible role of the
interferon system . -
pubmed
These data suggest that physical exercise may play an important role in the maintenance of
HDL mass and in the reduction of
CHD risk factors in women of postmenopausal years with
NIDDM . -
pubmed
Presence of
beta - hexosaminidase A alpha - chain mRNA in two different variants of
GM2 - gangliosidosis . -
pubmed
On the molecular level it has been shown , that poly ( A)+ RNA preparations from fibroblasts of patients with classical
Tay - Sachs disease lack detectable alpha - chain
message when analyzed by Northern blotting with complementary DNA encoding the alpha - chain of
human beta - hexosaminidase A. -
pubmed
In this report the
p beta H alpha-5 clone was used to investigate whether patients with two different variants of
Tay - Sachs disease also lack the alpha - chain
message . -
pubmed
The changes in serum
triglycerides ,
cholesterol and
high density lipoprotein (
HDL )
cholesterol were followed in
patients with
pneumonia caused by different
bacteria or viruses as well as in those with no defined aetiology . -
pubmed
2 ) a reduction in
cholesterol in all aetiological groups ( p less than 0.001 ) except for those with
viral pneumonias , where only 4
patients were studied , and 3 ) a fall in
HDL cholesterol in all the groups ( at least at p less than 0.05 ) except in those with
virus infection . -
pubmed
In the present study a monoclonal antibody against
estrogen receptor (
H222 Sp gamma ) was used on cryostat sections of freshly frozen breast
tumors with a peroxidase - antiperoxidase immunoperoxidase technique . -
pubmed
Hypopituitarism : a study of
growth hormone and other endocrine functions . -
pubmed
C - reactive protein in
malaria . -
pubmed
C - Reactive protein has not been studied in
malaria so far but with the reappearance of
malaria in the southern part of Iran there is now an opportunity to study the behaviour of
C - reactive protein in
malaria . -
pubmed
It may be concluded that
malaria is one of the outstanding diseases in which the
C - reactive protein test is positive . -
pubmed
Short
asthmatic children and
human growth hormone . -
pubmed
Albuminuria is below 25 mg / d/1.73 m2 and excretion of
beta 2 - microglobulin below 0.4 mg / d/1.73 m2 . -
pubmed
Dose - response studies were also performed in both salivary glands with different pharmacological agonists known to cause
salivation in the
rat (
methacholine ,
noradrenaline ,
isoproterenol ,
methoxamine and
substance P ) in the absence and in the presence of
ANF . -
pubmed
Synthetic inhibitors of
tissue kallikrein : effects in vivo in a model of
allergic inflammation . -
pubmed
Several of these were evaluated in vivo in the
ovalbumin - sensitised
guinea pig for their ability to prevent the
bronchoconstriction elicited by antigen challenge . -
pubmed
Inhibitors of
tissue kallikrein may prove effective in the treatment of
allergic inflammation in
man . -
pubmed
Sequential study of an experimental model of
graft vs. host disease (
GvHD ) in non - immunosuppressed F1 ( CBA / J
x C57BL/6 ) mice . -
pubmed
Long - term management of
adenomyosis with a
gonadotropin - releasing hormone agonist : a case report . -
pubmed
No evidence for association of
dopamine D2 receptor variant (
Ser311 /
Cys311 ) with
major psychosis . -
pubmed
We investigated a variant of the
dopamine D2 receptor gene (
Ser311 /
Cys311 substitution ) in Caucasian patients with
schizophrenia ( n = 273 ) ,
delusional disorder ( n = 62 ) ,
bipolar I affective disorder ( n = 63 ) , and controls ( n = 255 ) . -
pubmed
Thus , our results do not provide evidence for an association between this
D2 receptor variant and
schizophrenia , or
delusional disorder , or
bipolar affective disorder . -
pubmed
Study of autoantibodies against the
adenine nucleotide translocator in
idiopathic dilated cardiomyopathy . -
pubmed
The frequency , dynamical change and effects of autoantibodies against the
adenine nucleotide translocator (
ANT ) in
idiopathic dilated cardiomyopathy (
IDC ) were studied . -
pubmed
Sera of 16
patients with
IDC showed significant binding capacity to the
ANT protein ( 33.3 % ) . -
pubmed
Therefore , a short - term immunosuppressive treatment should be given to those
IDC patients whose
anti - ANT antibody is positive . -
pubmed
Studies of total proteins ,
lysozyme and
glucose in 25
patients ( 50 eyes ) with
Sjogren ' s disease and 26
patients ( 52 eyes ) with
Sjogren ' s syndrome have revealed a statistically significant reduction of tear production in patients vs. the normal subjects . -
pubmed
The Langerhans and lymphoid cells were counted using immunolabelling with antibodies against
CD1a ,
S100 ,
CD3 ,
CD20 , and
CD68 on paraffin - embedded sections of 24 archival laryngeal vocal cord mucosa biopsy specimens , 6 classified as simple , 7 as abnormal , and 11 as atypical epithelial
hyperplasia . -
pubmed
Association between
MICA gene A4 allele and acute
anterior uveitis in white patients with and without
HLA - B27 . -
pubmed
PURPOSE :
Acute anterior uveitis is strongly associated with the
HLA - B27 antigen and triggered by the involvement of some external factors . -
pubmed
However , it is uncertain whether
HLA - B27 itself or other gene(s ) near the
HLA - B region in a linkage disequilibrium with
HLA - B27 predispose to this
uveitis . -
pubmed
METHODS : We examined the following patients for
MICA gene polymorphism by means of polymerase chain reaction and subsequent automated fragment detection by fluorescent - based technology : 64 ( 37
HLA - B27 - positive and 27
HLA - B27 - negative ) whites with
acute anterior uveitis , 74 ( 67
HLA - B27 - negative and 7
HLA - B27 - positive ) ethnically matched random controls , and 36
HLA - B27 - positive healthy controls . -
pubmed
CONCLUSIONS : These results suggest that the
MICA gene itself or other nearby gene(s ) linked to the
MICA A4 allele may be involved in the development of acute
anterior uveitis in a white population . -
pubmed
NSAIDs cause
gastrointestinal damage by 2 independent mechanisms : a topical effect , which is pH and pKa related , and a systemic effect mediated by
cyclooxygenase (
COX ) inhibition with a reduction in
prostaglandin synthesis . -
pubmed
Among the strategies used to decrease the risk of
ulcer development are : ( i ) the use of analgesics other than NSAIDs ; ( ii ) use of the lowest possible dosage of NSAID ; ( iii ) the use of a
COX-2 selective NSAID ; ( iv ) the use of low doses of
corticosteroids instead of NSAIDs ; ( v ) avoidance of concomitant use of NSAIDs and
corticosteroids ; and ( vi ) use of preventive therapy . -
pubmed
In an attempt to reduce the incidence of NSAID - induced
gastrointestinal lesions , the following approaches have been proposed : ( i ) use of the
prostaglandin analogue
misoprostol , which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID - induced
gastric and duodenal ulcers as in the reduction of serious upper
gastrointestinal complications ; ( ii )
histamine H2 receptor antagonists ( H2 antagonists ) , e.g. -
pubmed
If NSAID treatment can not be withdrawn , a
proton pump inhibitor appears to be the most effective treatment in healing
ulcers , accelerating the slow healing observed with H2 antagonists . -
pubmed
Recent reports have demonstrated beneficial effects of
proinsulin C - peptide in the
diabetic state , including improvements of kidney and nerve function . -
pubmed
Standardization of cellular immunoenzyme assay for
anti - HLA class I antibodies evaluation : comparison with complement - dependent
cytotoxicity methods . -
pubmed
Zanamivir , an inhibitor of
neuraminidase , delivered via inhalation , shows promise in the treatment of uncomplicated
influenza infection , but more data are needed on its effectiveness and safety in
patients with preexisting
respiratory disease . -
pubmed
Surface expression of the lysosomal membrane protein
GP53 was significantly higher in the
hypertriglyceridemic patients at baseline as compared to the group of age- and sex - matched controls ( 16.3+/-4.8 % vs. 8.9+/-3.4 % , respectively , P<0.001 ) . -
pubmed
The deletion allele frequency of
ACE gene was slightly higher in
ischaemic stroke group , but with no statistic significance . -
pubmed
CONCLUSION : The results suggested that possible association existed between the use of COC and the onset of
hemorrhagic stroke , however the mutations of G1691 - ->A in
factor V gene , G20210 - ->A in
prothrombin gene and I / D polymorphism of
ACE gene did not seem to contribute to this association . -
pubmed
In multivariate analyses ,
human leucocyte antigen (
HLA ) disparity between donor and recipient and
chronic graft - versus - host disease were the leading causes affecting immune reconstitution . -
pubmed
Interestingly ,
cytomegalovirus ( CMV ) infections were strongly associated with normal
CD8 + T - cell counts . -
pubmed
Studying the impact of impaired immune reconstitution on the rate of
infections occurring in the 6 years following screening , we identified three parameters ( low B - cell count , inverted
CD4 /
CD8 ratio , and negative response to
tetanus toxin ) as significant risk factors for developing such late
infections . -
pubmed
BACKGROUND : The aim of this study was to identify the factors determining the circulating soluble
transferrin receptor (
sTfR ) concentrations in haemodialysis (
HD )
patients on maintenance recombinant
human erythropoietin (
rHuEpo ) treatment . -
pubmed
HD patients received constant
rHuEpo doses and basal
sEpo was measured & gt ; or = 86 h after the last injection . -
pubmed
RESULTS :
HD patients were similar to controls regarding haematocrit ,
serum ferritin ,
TS , and % HRC , but had significantly lower
sTfR ,
sEpo , and reticulocyte index . -
pubmed
Univariate analyses showed that the
sTfR level strongly correlated with
sEpo ( r=0.60 , P<0.001 ) and % HRC ( r=0.60 , P<0.001 ) , and significantly with serum
ferritin ( r=-0.29 , P<0.01 ) , TS ( r=-0.27 , P<0.05 ) , and dose of
rHuEpo administered ( r=0.27 , P<0.05 ) in
HD patients . -
pubmed
CONCLUSIONS : Circulating
sTfR is a good index of marrow erythropoietic activity in
HD patients during
rHuEpo treatment . -
pubmed
Serum
carcinoembryonic antigen level in surgically resected clinical stage I
patients with
non - small cell lung cancer . -
pubmed
BACKGROUND : There is little general agreement concerning the effectiveness of serum
carcinoembryonic antigen (
CEA ) as a prognostic indicator for
non - small cell lung cancer (
NSCLC ) in clinical stage I
patients . -
pubmed
Serum
CEA levels were measured with an enzyme - linked immunosorbent assay kit with the upper limit of normal defined as 7.0 ng / mL based on the 95 % specificity level for
benign lung disease , in our hospital . -
pubmed
The high
CEA group had a median survival time of 50 months and a 5 - year survival rate of 49 % compared with a 5 - year survival rate of 72 % ( p & lt ; 0.0001 ) for the
normal CEA group ( n = 241 ) . -
pubmed
CONCLUSIONS : Serum
CEA level is a useful predictor of survival for
patients with clinical stage I
NSCLC , and a persistently high
CEA level after surgery is an especially strong indicator of a very poor prognosis . -
pubmed
The " protein only " hypothesis holds that the infectious agent causing
transmissible spongiform encephalopathies is a conformational isomer of
PrP , a host protein predominantly expressed in brain and is strongly supported by many lines of evidence . -
pubmed
Coagulation Factor V Leiden has not been detected in Japanese patients suffering from
thromboses . -
pubmed
Correlations of
hemoglobin index ( IHb ) of gastric mucosa with
Helicobacter pylori ( H. pylori ) infection and
inflammation of gastric mucosa . -
pubmed
The
haemoglobin index ( IHb ) of the fundic mucosa is an objective parameter of the extent of mucosal redness , but it is unclear whether or not IHb can be used as a diagnostic marker for
H. - pubmed
pylori infection , inflammatory cell infiltration , and
IL-8 /
iNOS mRNA expression , suggesting that IHb is a reliable marker of
H. - pubmed
None of the
gonadoblastomas showed immunoreactivity with antibodies against
steroid hormone receptors and against
testosterone and
estradiol , respectively . -
pubmed
Although multiple studies suggest a potential role for
angiotensin II in
inflammation , most were performed either in vitro or in
animals with non - immune - complex - mediated diseases . -
pubmed
In autoimmune - prone MRL / lpr
mice ,
angiotensin - converting - enzyme (
ACE ) inhibition improved survival although to a lesser degree than
cyclophosphamide and diminished the
glomerular histopathologic damage ,
proteinuria ,
lymphoid hyperplasia ,
dermatitis , and
hypergammaglobulinemia , with a reduction in
TGF - beta1 and beta 2 expression in the kidneys and renal chemokine mRNA expression . -
pubmed
Uncontrolled studies in
patients with treatment - refractory
lupus nephritis showed a significant reduction in
proteinuria with
ACE - inhibitors and
Angiotensin receptor blockers treatment . -
pubmed
No single
ACE genotype was consistently associated with subsets of
SLE patients . -
pubmed
The use of
hepatotoxic signals to predict the safety of
peroxisome proliferator - activated receptor agonists . -
pubmed
Non - invasive imaging of
firefly luciferase reporter gene expression using bioluminescence imaging in
human prostate cancer models . -
pubmed
In the present study , we employed a CCD ( charge - coupled - device ) imaging system to monitor how a prostate - specific adenovirus vector ( AdPSA - Luc ) mediated the long - term , sustained expression of
firefly luciferase (
Luc ) in living
human prostate cancer mouse models . -
pubmed
Systemic tail vein injection of AdPSA -
Luc revealed significant luciferase expression in lungs of both
human prostate cancer mouse models and naive
mice , but significantly higher in the former , while the control virus ,
AdCMV - Luc , containing
CMV ( cytomegalovirus ) promoter and luciferase gene , just restricted expression in the livers . -
pubmed
Acceleration of
wound healing in aged
rats by topical application of
transforming growth factor - beta ( 1 ) . -
pubmed
The impaired
wound healing associated with aging may reflect inadequate secretion or delivery of
cytokines . -
pubmed
Transforming growth factor - beta ( 1 ) is a mitogenic polypeptide with beneficial effects on
wound healing . -
pubmed
In the present study we questioned whether topical administration of
transforming growth factor - beta ( 1 ) could improve the
wound healing process in aged
rats in vivo . -
pubmed
In addition , the number of capillaries per unit area of the wound as determined by a stain for
Griffonin ( Bandeiraea ) simplicifolia lectin , and the number of inflammatory cells as identified by an antibody specific for macrophages , were also reduced in the
wound area in old
rats . -
pubmed
Treatment with
transforming growth factor - beta ( 1 ) resulted in marked enhancement of the following parameters : cell proliferation , inflammatory cell and fibroblast influx ,
wound closure , and angiogenesis . -
pubmed
Treatment with
transforming growth factor - beta ( 1 ) subsequently resulted in an increase in the expression of both
type I procollagen and
Secreted Protein , Acidic and Rich in
Cysteine mRNA in the
wound tissue from aged
rats . -
pubmed
In summary , a single topical application of
transforming growth factor - beta ( 1 ) to the wounds of aged
rats at the time of wounding was associated with a healing response that , in all the parameters of
wound repair examined , was similar to that of young
rats . -
pubmed
Topical
transforming growth factor - beta ( 1 ) might therefore be beneficial in the treatment of
dermal wounds in the aged . -
pubmed
Recently , association of an
interleukin-1A promoter polymorphism ( -889 ,
thymine /
thymine ( T / T ) ) with
Alzheimer ' s disease was reported , suggesting that this
cytokine may play an important role in disease development . -
pubmed
To understand the mechanism underlying the
interleukin-1A promoter 's role in
Alzheimer ' s disease , a study comparing promoter function of an
interleukin-1A polymorphism was performed in the
SVG astroglia cell line . -
pubmed
As discussed ,
BRIN - BD11 cells have facilitated studies aimed at dissecting important pathways by which nutrients and other bioactive molecules regulate the complex mechanisms regulating
insulin secretion , and highlight the future potential of novel and diverse bioengineering approaches to provide a cell - based
insulin - replacement therapy for
diabetes . -
pubmed
Clonal
BRIN - BD11 beta - cells have been instrumental in : ( a ) characterization of
K ( ATP ) channel - dependent and -independent actions of nutrients and established and emerging insulinotropic antidiabetic drugs , and the understanding of drug - induced beta - cell desensitization ; ( b ) tracing novel metabolic and beta - cell secretory pathways , including use of state - of - the - art NMR approaches to provide new insights into the relationships between
glucose and
amino acid handling and
insulin secretion ; and ( c ) determination of the chronic detrimental actions of nutrients and the
diabetic environment on pancreatic beta - cells , including the recent discovery that
homocysteine , a risk factor for
metabolic syndrome , may play a role in the progressive demise of
insulin secretion and pancreatic beta - cell function in
diabetes . -
pubmed
Arginine rich , mutated in early stage of
tumors (
ARMET ) was first identified as a
human gene highly mutated in a variety of
cancers . -
pubmed
To design a practical approach for a molecular diagnosis of micrometastasis , we applied direct DNA sequencing to screen 48 early stage colorectal
carcinomas for the most frequent mutations of the
KRAS ,
P53 , and
APC tumor genes . -
pubmed
In contrast , the frequency of
P53 and
APC hot spot mutations was unexpectedly low , compared with previous studies using other screening methods or including advanced
tumor stages . -
pubmed
Applying mutant - enriched polymerase chain reaction ( PCR ) , the mutation of the primary
tumor was detected in lymph node DNA from 2 of the
KRAS - positive patients . -
pubmed
Second case of
Beare - Stevenson syndrome with an
FGFR2 Ser372Cys mutation . -
pubmed
[ Dysfunctions of
potassium channels and
Parkinson ' s disease ] . -
pubmed
Dose - dependent
thrombus resolution due to oral
plaminogen activator inhibitor ( PAI )- 1 inhibition with
tiplaxtinin in a
rat stenosis model of
venous thrombosis . -
pubmed
This study aimed to evaluate a small - molecule
PAI-1 inhibitor (
PAI-039 ;
tiplaxtinin ) in a rodent
stenosis model of
venous thrombosis in a two - phase experiment . -
pubmed
Phase 1
animals ( n = 24 ) receiving low - dose ( LD ; 1 mg / kg oral gavage )
PAI-1 inhibitor demonstrated a 52 % decrease in
thrombus weight ( TW ) versus controls ( p & lt ; 0.05 ) with significant reductions in active plasma
PAI-1 , while the high - dose ( HD ; 10 mg / kg oral gavage ) group demonstrated a 23 % reduction in TW versus controls . -
pubmed
Insulin secretion in metabolically obese , but normal weight , and in metabolically healthy but
obese individuals . -
pubmed
Additionally , metabolically healthy but
obese (
MHO )
individuals have been identified who are relatively
insulin sensitive and have a favorable cardiovascular risk profile . -
pubmed
We compared
insulin secretion patterns of MONW and MHO with those of two age - matched groups comprising nonobese
individuals or
obese insulin - resistant subjects , respectively . -
pubmed
To this end , 110 nonobese subjects and 87
obese subjects were stratified into quartile based on their
insulin - stimulated
glucose disposal ( M(FFM ) ) . -
pubmed
Disposition index did not differ between MONW and
insulin - resistant
obese . -
pubmed
M(FFM ) was higher in
MHO who exhibited lower waist circumference , blood pressure ( BP ) ,
triglycerides , FFA ,
insulin levels , and higher
high - density lipoprotein (
HDL )
cholesterol compared to
insulin - resistant
obese . -
pubmed
Insulin secretion did not differ between
insulin - resistant
obese and
MHO , but disposition index was lower in the former group . -
pubmed
In conclusion , MONW and
insulin - resistant
obese showed decreased compensatory
insulin secretion compared to normal nonobese and
MHO subjects , respectively . -
pubmed
We found that the formation of yolk sac hemogenic endothelium and its hematopoietic potential were significantly impaired in the absence of
retinoic acid ( RA ) signaling , and could be restored in
RA - deficient (
Raldh2(-/- ) ) embryos by provision of exogenous
RA in utero . -
pubmed
Hepatocyte growth factor activator inhibitor-2 (
HAI-2 ) is a favorable prognosis marker and inhibits cell growth through the apoptotic pathway in
cervical cancer . -
pubmed
We investigated the role of
hepatocyte growth factor activator inhibitor-2 (
HAI-2 ) and evaluated its clinical importance in
cervical cancer . -
pubmed
PATIENTS AND METHODS :
HAI-2 expression was examined in
cervical cancer specimens ( n=52 ) by immunohistochemistry . -
pubmed
We further attempted to investigate the biological functions and inhibitory effects of
HAI-2 using
human papillomavirus ( HPV ) 16 type
SiHa and
HPV 18 type
HeLa cervical cancer cell lines . -
pubmed
CONCLUSIONS : The present findings indicate that low
HAI-2 expression in
cervical cancer may be associated with a poor prognosis . -
pubmed
We propose that
HAI-2 may represent a therapeutic target for the treatment of
cervical cancer . -
pubmed
Anemia should , therefore , be considered as a useful prognosticator , and therapeutic strategies aimed to increase
hemoglobin levels in
CHF should be investigated . -
pubmed
CONCLUSION : It can be inferred that : ( i )
IL-12 profiles alone may represent a relevant indicator of heavy metal - induced immune modulation ; ( ii ) evaluating
cytokine profiles by CBA is relevant and can adequately replace other methods such as ELISA and RT - PCR in basic research as well as in immune diagnostics ; and ( iii ) targeting
IL-12 in therapeutic approaches may be promising to modify Th1 / Th2 - associated
immune disorders . -
pubmed
The DNA repair proteins
BRCA1 and
ERCC1 as predictive markers in
sporadic ovarian cancer . -
pubmed
This study compares
Breast Cancer 1 (
BRCA1 ) and
excision repair cross complementation group 1 (
ERCC1 ) expression as predictive markers and evaluates the in vitro enhancement of
platinum sensitivity using targeted agents in
sporadic ovarian cancer (
OC ) . -
pubmed
High
BRCA1 was predictive of poorer OS specifically in patients with residual
disease ( RD ) & lt;2 cm ( p = 0.03 ) . -
pubmed
In summary , this study shows that low
BRCA1 and
ERCC1 expression correlate with improved survival in advanced
OC and
HDAC inhibition induces synergistic
cytotoxicity with
platinum in vitro . -
pubmed
The role of
CX3CR1 , a chemokine receptor expressed in microglia , in regulating microglia morphology and dynamic behavior in the resting state and after laser - induced
focal injury was examined . -
pubmed
CX3CL1 signaling from retinal neurons and endothelial cells likely modulates dynamic microglia behavior so as to influence the level of microglial surveillance under basal conditions and the rate of dynamic behavior in response to
tissue injury . -
pubmed
Age - related loss of phospholipid asymmetry in
APP(NLh)/
APP(NLh ) x
PS-1(P264L)/
PS-1(P264L )
human double mutant knock - in
mice : relevance to
Alzheimer disease . -
pubmed
Using
APP(NLh)/
APP(NLh ) x
PS-1(P246L)/
PS-1(P246L )
human double knock - in (
APP /
PS-1 )
mice , we examined whether
phosphatidylserine (
PtdSer ) asymmetry is significantly altered in brain of this
familial Alzheimer disease mouse model in an age - dependent manner as a result of oxidative stress , toxic
Abeta(1 - 42 ) oligomer production , and/or apoptosis . -
pubmed
We postulated that a
tumor suppressor present in
mammals but absent in regenerative
vertebrates , the
Ink4a product
ARF ( alternative reading frame ) , is a regeneration suppressor . -
pubmed
Targeting of
alpha - hemolysin by active or passive immunization decreases severity of
USA300 skin infection in a
mouse model . -
pubmed
We tested the hypothesis that
alpha - hemolysin (
Hla ) contributes to the severity of
USA300 skin infections in
mice and determined whether vaccination against
Hla reduces disease severity . -
pubmed
Passive immunization with Hla - specific antisera or active immunization with a nontoxigenic form of
Hla significantly reduced the size of
skin lesions caused by
USA300 and prevented
dermonecrosis . -
pubmed
ACE inhibitors for the treatment of
hypertension drug selection by means of the SOJA method . -
pubmed
ACE inhibitors have proven to be effective blood
pressure lowering agents with an excellent tolerability profile . -
pubmed
Tumor cells coexpressed
EMA and
GLUT-1 , and a minority immunoreacted for
smooth muscle actin . -
pubmed
METHODOLOGY / PRINCIPAL FINDINGS : Here we addressed whether NK cells have the potential to control
chronic myeloid leukemia (
CML ) arising based on the transplantation of
BCR -
ABL1 oncogene expressing primary bone marrow precursor cells into lethally irradiated recipient
mice . -
pubmed
Since the presence of NK cells reduced the abundance of
leukemia propagating
cancer stem cells , the data raise the possibility that NK cell recognition has the potential to cure
CML , which may be difficult using small molecule
BCR -
ABL1 inhibitors . -
pubmed
Finally , our findings validate approaches to treat
leukemia using antibody - based blockade of self - specific inhibitory
MHC class I receptors . -
pubmed
In
murine experimental
colitis in - vivo ,
myeloperoxidase activity decreased significantly in
2,4,6 - trinitrobenzenesulfonic acid (
TNBS)-
colitis and
oxazolone (
OXA)-
colitis models after treatment with ClNP while free
clodronate did not show a mitigating effect . -
pubmed
Similarly ,
alkaline phosphatase could be lowered significantly from 12.5 + -1.9 to 6.8 + -2.2ng / mg tissue in TNBS -
colitis and from 16.6 + -6.2 to 11.8 + -2.7ng / mg tissue in OXA -
colitis . -
pubmed
Our work also provides important insights in disease like
Robinow syndrome ,
brachydactyly type B1 (
BDB1 ) and
spina bifida , which can be caused by
human mutations in the
Wnt / PCP signaling pathway . -
pubmed
When serum from a 6 week clinical intervention with dietary supplements containing olive oil ( control ) ,
DHA , or two levels of
EPA were applied to
THP-1 cells , the expression of
SCD and
FADS2 decreased in the cells treated with serum from the
omega3 - PUFA - supplemented
individuals . -
pubmed
G Protein beta3 subunit gene C825 T polymorphism and its association with the presence and clinicopathological characteristics of
prostate cancer . -
pubmed
We investigated the possible association of
GNB3 gene polymorphism with
prostate cancer and its clinicopathological characteristics . -
pubmed
RESULTS : The frequency of the
GNB3 825 T allele in patients with
prostate cancer was significantly higher than in controls ( 49.1 % vs 42.7 % , OR 3.76 , p = 0.003 ) . -
pubmed
Men lacking the C825 allele were at approximately sevenfold higher risk for high grade ( Gleason score greater than 7 )
prostate cancer than men with the
GNB3 CC genotype . -
pubmed
CONCLUSIONS : Our study presents preliminary but intriguing data suggesting that
GNB3 gene polymorphism influences susceptibility to
prostate cancer . -
pubmed
A new
Cylindromatosis (
CYLD ) gene mutation in a case of
Brooke - Spiegler syndrome masquerading as
basal cell carcinoma of the eyelids . -
pubmed
Although the exact etiology and pathogenesis of
EoE remain unclear , it is now generally accepted that it is the result of a T - helper cell 2 - type immune response with a crucial role for the eosinophil - specific chemotaxis factor
eotaxin 3 and eosinophils . -
pubmed
(1 ) T(H)1 produce
interferon - gamma (
IFNgamma ) and are important for protective immune responses to intracellular viral ,
bacterial and parasitic infection . -
pubmed
Serum
calcium level , fasting blood
glucose level ( FBG ) ,
hexokinase activity ,
glucose-6 - phosphatse and
fructose 1,6 bisphosphatase activity were measured to establish a relevant correlation between
vitamin D supplementation and
hyperglycemia in
T2DM . -
pubmed
The activity of the
glucose metabolic enzymes was also assayed in
diabetic group and was found to be deviated from control group ;
hexokinase ( 0.0241 + - 0.014 mug / mg / ml )
FBPase ( 0.433 + - 0.002 mug / mg / ml ) and
G6Pase ( 0.918 + - 0.02 mug / mg / ml ) . -
pubmed
Besides , the activity of various
glucose metabolic enzymes (
hexokinase ,
FBPase and
G6Pase ) as shown by our results and the remarkable shortening of DNA tail length in
vitamin D supplemented
diabetic group as compared to
diabetic group without supplementation further support the idea that
vitamin D supplementation might be an add - on therapy for
patients with
T2DM . -
pubmed
[ Protective effects of
SUR2B /
Kir6.1 potassium channel opener
natakalim against
RAVECs injuries induced by
hypoxia ] . -
pubmed
RESULTS :
Natakalim could reverse
hypoxia - induced changes in endothelial cell function , including increased endothelial cell survival rate and level of
NO concentration , significantly inhibited the
hypoxia - induced endothelial
ICAM-1 ,
ET-1 ,
VEGF mRNA expression levels increased . -
pubmed
CONCLUSION :
Natakalim have protective effects on
hypoxia - induced changes in endothelial cell function , increasing of permeation , excess expression of
cell adhesion molecules . -
pubmed
In vivo , the results showed that CPs could not only inhibit the growth of the
tumor , but also enhance the spleen index , as well as the level of
IL-2 ,
IFN - gamma and
TNF - alpha . -
pubmed
The protein
p53 functions as a
tumor suppressor and can trigger either cell cycle arrest or apoptosis in response to DNA damage . -
pubmed
Attractor landscape analysis of the cellular response to DNA damage of the
breast cancer cell line
MCF7 and the effect of the
Mdm2 (
murine double minute 2 ) inhibitor
nutlin-3 indicated that
nutlin-3 would exhibit limited efficacy in triggering cell death , because the cell death state was not induced to a large extent by simulations with
nutlin-3 and instead produced a state consistent with oscillatory
p53 dynamics and cell cycle arrest . -
pubmed
Thus , attractor landscape analysis of
p53 network dynamics and its regulation can identify potential therapeutic strategies for treating
cancer . -
pubmed
To assess the prevalence of specific
IgE in electrophoretically separated
ragweed pollen proteins , individual reactivity of sera from
dogs with
CAD was analyzed and compared to the reactivity of sera from healthy
dogs in the non - reducing conditions , which were found optimal for specific
canine IgE detection . -
pubmed
A specific
IgE band ( 38 kDa ) was recognized as the most dominant allergen in
CAD , occurring in 81 % of positive
dog 's sera . -
pubmed
2 - D immunoblotting followed by a mass spectrometry peptide fingerprint analyses with pooled
canine and
human atopic sera , revealed that 38 kDa major
Ambrosia atremisiifolia allergens in
CAD were all five isoallergens of the
Amb a 1 group (
antigen E ) , including the previously named
Amb a 2 (
antigen K ) . -
pubmed
The most prominent ragweed proteins in
CAD , represent , as in
humans , variants of all five isoallergens of the
Amb a 1 group (
pectate lyase ):
Amb a 1.0101 and its natural variant
E1XUL2 ,
Amb a 1.0202 , 1.0304 , 1.0402 and the natural variant of
Amb a 1.0501 ,
E1XUM0 , as well as the alpha fragment of pollen allergen
Amb a 1.0201 . -
pubmed
Biologically , the complex successfully downregulated the expression of
LMP1 in
nasopharyngeal carcinoma cells . -
pubmed
In a
mouse tumor xenograft model , the complex was shown to be delivered efficiently to
tumor tissue , downregulating expression of
LMP1 and suppressing
tumor growth . -
pubmed
In studying
dyslipidemia in Pakistan ,
hypertriglyceridemia is found in 27 - 54 % of the population , whereas 68 - 81 % has low levels of high - density lipoprotein (
HDL ) . -
pubmed
Shank mutant
mice as an
animal model of
autism . -
pubmed
In this review , we focus on the role of the
Shank family of proteins in
autism . -
pubmed
Here , we analyse studies that relate
Shank to
autism and discuss what light this sheds on the possible causes of
autism . -
pubmed
Concomitance of
IgM and
IgG anti - dsDNA Antibodies Does Not Appear to Associate to Active
Lupus Nephritis . -
pubmed
Previous reports proposed that the
IgM anti - dsDNA antibody is protective for
lupus nephritis . -
pubmed
In this cross - sectional study , we aimed to compare clinical features of
systemic lupus erythematosus (
SLE ) patients positive for
IgG anti - dsDNA alone with those presenting both
IgG and
IgM anti - dsDNA . -
pubmed
Fifty - eight
SLE patients ( 93.1 % female , 81 % European - derived , mean age 42.8 + -14.7 years , mean duration of disease 10.9 + -8 years ) positive for
IgG anti - dsDNA entered the study . -
pubmed
The group with both isotypes showed significant less frequency of active
nephritis ( sediment changes and
proteinuria ) when compared to patients with
IgG anti - dsDNA alone ( 6.7 % versus 34.9 % , p=0.046 ) . -
pubmed
These data suggest a nephroprotective role for
IgM anti - dsDNA and a distinct biologic behavior for this isotype in
SLE . -
pubmed
In
food allergies , especially in
type I allergic reactions , dietary fat can modulate the development of clinical symptoms through influencing the production of immunoglobulins ( Ig ) ,
cytokines and chemical mediators . -
pubmed
Renin -
angiotensin system genetic polymorphisms and
brain white matter lesions in older Australians . -
pubmed
The associations of single nucleotide polymorphisms ( SNPs ) in the genes encoding
angiotensinogen (
AGT , rs699 ) ,
angiotensin - converting enzyme (
ACE , rs4362 ) , and
angiotensin II receptor type 1 (
AGTR1 , rs5182 ) with
WMLs were examined . -
pubmed
When the cohort was stratified by sex ,
ACE rs4362 and
AGT rs699 showed significant associations with
WMLs in men only ( P = 0.01 and P = 0.03 , respectively ) , and remained significant after controlling for
hypertension . -
pubmed
Although the
AGTR1 SNP did not show any association with
WMLs , the interaction of the
AGT rs699 and
AGTR1 rs5182 SNPs with
WMLs was significant before ( P = 0.03 ) and after adjustment for
hypertension ( P = 0.045 ) . -
pubmed
CONCLUSIONS : The results provide evidence for association of polymorphisms in the
renin -
angiotensin system genes with
WMLs , independent of
hypertension . -
pubmed
Male - only associations with
WMLs were found for the
AGT rs699 and
ACE rs362 polymorphisms . -
pubmed
Moreover , for the entire sample an interaction between
AGT and
AGTR1 rs5182 genotypes on
WMLs was observed . -
pubmed
Prescriptions for long - term management varied among districts , as follows : inhaled
corticosteroids ( ICS ) , mean of 37.3 % ( 0 - 66.7 % ) ; ICS / long - acting beta - agonists ( LABA ) , 27.9 % ( 16.7 - 66.7 % ) ; and
leukotriene receptor antagonist ( LTRA ) , 20.5 % ( 0 - 50.0 % ) CONCLUSION : These findings suggest that
asthma treatment in emergency settings varies by facility and region . -
pubmed
At the age of 4 mo , he was diagnosed as having
CNDI , judging from
fever with
hypernatremia ( serum
Na 153 mEq / L ) , diluted urine ( urine osmolarity 193 mOsm / kg ) , high antidiuretic hormone (
plasma antidiuretic hormone 53 pg / mL ) , and normal renal function ( serum
creatinine 0.3 mg / dL ) . -
pubmed
BACKGROUND :
Thymic stromal lymphoproetin (
TSLP ) is a
cytokine secreted by the airway epithelium in response to respiratory viruses and it is known to promote allergic Th2 responses in
asthma . -
pubmed
This study investigated whether virally - induced secretion of
TSLP is directional in nature ( apical vs. basolateral ) and/or if there are
TSLP - mediated effects occurring at both sides of the bronchial epithelial barrier in the
asthmatic state . -
pubmed
METHODS : Primary
human bronchial epithelial cells ( HBEC ) from control ( n = 3 ) and
asthmatic ( n = 3 ) donors were differentiated into polarized respiratory tract epithelium under air - liquid interface ( ALI ) conditions and treated apically with dsRNA ( viral surrogate ) or
TSLP . -
pubmed
Sub - epithelial effects of
TSLP were examined in
human airway smooth muscle cells ( HASMC ) from normal ( n = 3 ) and
asthmatic ( n = 3 ) donors . -
pubmed
RESULTS : Our data demonstrate that : 1 ) Asthmatic HBEC exhibit an exaggerated apical , but not basal , secretion of
TSLP after dsRNA exposure ; 2 )
TSLP exposure induces unidirectional ( apical ) secretion of
CCL11 /
eotaxin-1 in asthmatic HBEC and enhanced
CCL11 /
eotaxin-1 secretion in asthmatic HASMC ; 3 ) Rhinovirus - induced
asthma exacerbations in
children are associated with in vivo airway secretion of
TSLP and
CCL11 /
eotaxin-1 . -
pubmed
CONCLUSIONS : There are virally - induced
TSLP - driven secretory immune responses at both sides of the bronchial epithelial barrier characterized by enhanced
CCL11 /
eotaxin-1 secretion in
asthmatic airways . -
pubmed
The effect of
simvastatin on inflammatory
cytokines in community - acquired
pneumonia : a randomised , double - blind , placebo - controlled trial . -
pubmed
OBJECTIVES : It has been suggested that
statins have an effect on the modulation of the
cytokine cascade and on the outcome of
patients with
community - acquired pneumonia (
CAP ) . -
pubmed
The aim of this prospective , randomised , double - blind , placebo - controlled trial was to determine whether statin therapy given to hospitalised
patients with
CAP improves clinical outcomes and reduces the concentration of inflammatory
cytokines . -
pubmed
CONCLUSIONS : Our results suggest that the use of
simvastatin , 20 mg once daily for 4 days , since hospital admission did not reduce the time to clinical stability and the levels of inflammatory
cytokines in hospitalised
patients with
CAP . -
pubmed
Some of the target compounds exhibited moderate to excellent
mTOR /
PI3Kalpha kinase inhibitory activity and
cytotoxicity . -
pubmed
PLAC8 was highly expressed in GDM - exposed ECFCs , and
PLAC8 expression correlated with maternal
hyperglycemia . -
pubmed
We found that autophagic vacuoles and
SQSTM1 - positive proteins accumulated in TECs from
patients with
DN and in
human renal tubular epithelial cell line (
HK-2 cells ) treated with advanced glycation end products ( AGEs ) , the important factors that involved in the pathogenesis of
DN . -
pubmed
Rescue of
GABAB and
GIRK function in the lateral habenula by
protein phosphatase 2A inhibition ameliorates
depression - like phenotypes in
mice . -
pubmed
As a consequence ,
PP2A inhibition ameliorates
depression - like symptoms after FsE and in a learned - helplessness model of
depression . -
pubmed
Furthermore , its reversal by
PP2A inhibition may provide a novel therapeutic approach to alleviate symptoms of
depression in disorders that are characterized by LHb
hyperactivity . -
pubmed
Copy Number Variations of the
Azoospermia Factor Region and
SRY Are Not Associated with the Risk of
Hypospadias . -
pubmed
We analyzed the copy number of the
azoospermia factor (
AZF ) region and
SRY , using multiplex ligation - dependent probe amplification . -
pubmed
The results imply that CNVs in the AZF region and
SRY are not associated with the risk of
hypospadias in the Japanese population , although the pathogenicity of the AZF - linked simple duplication remains to be elucidated . -
pubmed
This phenomenon was initially attributed to different
gr /
gr subtypes that would eliminate distinct members of the
affected gene families . -
pubmed
Hepatocyte growth factor promotes proliferation , invasion , and metastasis of
myeloid leukemia cells through
PI3K -
AKT and
MAPK /
ERK signaling pathway . -
pubmed
HGF and
c - Met expression in first - vist
AML group was significantly higher than in
AML - relief and normal control group . -
pubmed
In conclusion ,
HGF and
c - Met gene highly expressed among first - visit
AML patients , but decreased after relief treatment . -
pubmed
HGF may promote proliferation , invasion , and metastasis of
AML cells through
PI3K -
AKT and
MAPK /
ERK signaling pathway . -
pubmed
Therefore , proliferation and invasion ability of
AML cell can be inhibited by down - regulating
HGF gene to retardate cell in G2 / M stage . -
pubmed
A consistent inhibitory effect of
ticagrelor 60 mg bid was observed pre- and post - dose regardless of
diabetes status , even in
insulin - treated
patients . -
pubmed
For laboratory evaluation ,
cholestasis parameters (
bilirubin ,
gamma - GT ) , liver cell parameters (
ASAT ,
ALAT ) and liver synthesis parameters ( quick ,
albumin ) were determined . -
pubmed
Furthermore , we used the mRNA of
IL-33 ,
GADD45a and
p-21 for analyzing cellular stress and regeneration in
cholestatic rats . -
pubmed
RESULTS : In chemical laboratory and histological evaluation , a distinction between acute and chronic
cholestatic liver injury with identification of
inflammation and regeneration could be demonstrated by an increase in
cholestasis (
bilirubin : 1 - wk group , 156.83 + - 34.12 mumol / L , P = 0.004 ) and liver cell parameters (
ASAT : 2 - wk group , 2.1 + - 2.19 mumol / L.s , P = 0.03 ;
ALAT : 2 - wk group , 1.03 + - 0.38 mumol / L.s , P = 0.03 ) after bile duct ligation ( BDL ) . -
pubmed
Furthermore , the
inflammation could be verified by ASDCL ( 4 - wk group , 22 + - 5.93 positive cells per portal field , P = 0.041 ) and
HMGB-1 [ 2 - wk group , 13 + - 8.18 positive cells per field of view ( FoV ) , P = 0.065 ] staining . -
pubmed
Additionally , to establish the
chronic cholestasis model , we evaluated liver regeneration capacity through measurements of
IL-33 ,
p-21 and
GADD45a mRNA . -
pubmed
Procalcitonin , erythrocyte sedimentation rate and
C - reactive protein in acute pulmonary exacerbations of
cystic fibrosis . -
pubmed
CONCLUSIONS : ESR and
CRP are useful markers for
CF exacerbations , as levels rise with exacerbations . -
pubmed
Baseline elevations in
ESR and
CRP were noted to show an increased risk for
CF exacerbations . -
pubmed
EFFECT OF
LEPTIN ON THE GALLBLADDER IN
PATIENTS WITH
METABOLIC SYNDROME . -
pubmed
It was shown that
leptin level in CNC
patients with
MS was 2.61 times that in healthy subjects ( p & lt;0.001 ) and 2.47 times higher than in CNC
patients without
MS ( p & lt;0.001 ) . -
pubmed
Defects in mismatch repair : the Achilles heel of
estrogen receptor positive
breast cancer with intrinsic endocrine therapy resistance ? -
pubmed
Exenatide Inhibits the
KCa3.1 Channels of Aortic Vascular Smooth Muscle in
Diabetic Rats . -
pubmed
Background :
KCa3.1 ion channels play an important role during
atherosclerosis . -
pubmed
We aimed to investigate the effect of exenatide on
KCa3.1 expression in aortic vascular smooth muscle cells ( VSMCs ) of
diabetic rats . -
pubmed
Results : Aortic tissue staining in the
DM group revealed an absence of smooth or integrated endothelium , increased smooth muscle cell proliferation in the media , smooth muscle
hyperplasia , disorganized smooth muscle cells , and an increased number of
collagen fibers , relative to the NC and ET groups . -
pubmed
KCa3.1 mRNA expression was higher in the
DM group than in the NC and ET groups . -
pubmed
Similarly , the
KCa3.1 protein level was higher in the
DM group than in the NC and ET groups . -
pubmed
Conclusions : Exenatide could inhibit the expression of the
KCa3.1 channel in VSMCs of
diabetic rats . -
pubmed
We also identified 18 targeting genes by super - enhancers with prognostic significance for
ovarian cancer , such as the
tumour suppressor
CDKN1B. -
pubmed
Although the exact mechanism of the development of
ovarian cysts is unknown , it is thought that increased
androgen levels stimulate folicle development by increasing
follicle stimulating hormone (
FSH ) levels . -
pubmed
Cadmium disrupts signaling of the
hypoxia - inducible (
HIF ) and
transforming growth factor ( TGF - beta ) pathways in placental JEG-3 trophoblast cells via reactive
oxygen species . -
pubmed
While a precise mechanism is unknown , oxidative imbalance and dysregulation of the
hypoxia inducible factor (
HIF ) and
transforming growth factor beta (
TGF - beta ) pathways have been implicated in
placental disease pathogenesis . -
pubmed
In addition to describing how to perform the EEG - ECG recordings , we also detail methods to quantify the resulting data for
seizures , EEG spectral power , cardiac function , and heart rate variability , which we demonstrate in an example experiment using a
mouse with
epilepsy due to
Kcna1 gene deletion . -
pubmed
As observed in
cancer patients , we found that
mTOR , a key signalling molecule responsible for maintaining cell growth and autophagy was suppressed in this model . -
pubmed
Tumor bearing
mice hearts show increased expression and nuclear localization of
TFEB and
FoxO3a transcription factors , which are involved in the upregulation of
muscle atrophy genes , lysosomal biogenesis genes and autophagy genes . -
pubmed
CYP2D6 genotype and
endoxifen plasma concentration do not predict
hot flash severity during
tamoxifen therapy . -
pubmed
There is paucity of prospectively collected data in terms of
CYP2D6 genotype and measured
tamoxifen ,
4 - hydroxytamoxifen and
endoxifen concentrations in relation to
hot flash severity during
tamoxifen therapy . -
pubmed
Genetic variation in
CYP2D6 or
CYP3A4 was not predictive of
hot flash severity . -
pubmed
Ertugliflozin is a highly selective inhibitor of
SGLT2 , and was approved in the US for the treatment of
adults with
T2DM . -
pubmed
Advantages of
ertugliflozin include reduction in glycated
hemoglobin ,
weight loss and blood pressure lowering with a low risk of
hypoglycemia . -
pubmed
Objective : To investigate the attainment of therapeutic targets for glycosylated
hemoglobin and blood pressure , ophthalmologic examination , diagnosis and treatment of
diabetic retinopathy (
DR ) with
type 2 diabetes mellitus . -
pubmed
Conclusions : The investigation of the type 2
diabetic patients in a community of Fushun indicated that more than 60 % of patients did not attain therapeutic targets for
glycosylated hemoglobin , and 70 % for blood pressure ; 78 % had not received ophthalmologic examination after the diagnosis of
diabetes mellitus ; 82 % of vision - threatening
DR patients had not been treated . -
pubmed
Anti - epidermal growth factor receptor (
EGFR ) monoclonal antibody combined with
cisplatin and
5 - fluorouracil in
patients with
metastatic nasopharyngeal carcinoma after radical radiotherapy : a multicentre , open - label , phase II clinical trial . -
pubmed
BACKGROUND : We conducted a single - arm phase II trial to evaluate the efficacy and adverse effects ( AEs ) of an anti -
epidermal growth factor receptor monoclonal antibody ,
nimotuzumab , combined with
cisplatin and
5 - fluorouracil ( PF ) as first - line treatment in recurrent metastatic
nasopharyngeal carcinoma after radical radiotherapy . -
pubmed
, against
myeloperoxidase or
proteinase-3 ) and
systemic lupus erythematosus (
SLE ) ( i.e. -
pubmed
Immunologic
congenital atrioventricular block is due to the presence of anti -
SSA and anti -
SSB antibodies in maternal blood . -
pubmed
RESULTS : The
carcinoembryonic antigen level before treatment , postoperative complications , pathology after neo - adjuvant therapy ( ypT , ypN ) , lymphatic invasion , venous invasion and pathological response of the primary
tumor were significant factors in a comparison of
patients with and without early recurrence . -
pubmed
Expression of
gamma - H2AX and patient prognosis in
breast cancer cohort . -
pubmed
In the present study , we assessed the
gamma - H2AX expression , its association with other clinicopathologic characteristics , and the prognosis in a cohort of 97
patients with
breast cancer . -
pubmed
The positive rates of
H2AX were 26.0 % and 2.6 % in
tumor tissue and adjacent
normal tissues , respectively . -
pubmed
gamma - H2AX expression could be a potential biomarker for
cancer diagnosis and prediction , and further studies are in need . -
pubmed
Expression of
prostaglandin E2 receptor 3 in the eyelid epidermis of
patients with
Stevens - Johnson syndrome /
toxic epidermal necrolysis . -
pubmed
BACKGROUND / AIMS : In a previous genome - wide association study of
Stevens - Johnson syndrome /
toxic epidermal necrolysis (
SJS /
TEN ) patients we reported the association between
SJS /
TEN and the
prostaglandin E receptor 3 (
PTGER3 ) gene , and that its protein
PGE2 receptor 3 (
EP3 ) was markedly downregulated in the conjunctival epithelium of
SJS /
TEN patients . -
pubmed
Here we examined
EP3 expression of the eyelid epidermis in
SJS /
TEN patients with severe
ocular complications and investigated the function of
EP3 . -
pubmed
METHODS : For the immunohistochemical study , we obtained eyelid samples from five
SJS /
TEN patients and five
patients without
SJS /
TEN ( control subjects ) who were undergoing surgery to treat
trichiasis , and investigated the expression of
EP3 protein in the epidermis of those samples . -
pubmed
RESULTS : The results of the immunohistochemical study revealed that
EP3 expression in the eyelid epidermis of the
SJS /
TEN patients was the same as that in the controls . -
pubmed
CONCLUSION : Our findings revealed that in chronic - phase
SJS /
TEN ,
EP3 protein was expressed in the eyelid epidermis and was not downregulated , unlike in conjunctival epithelium , and that
PGE2 could suppress
cytokine production via
EP3 in
human epidermal keratinocytes . -
pubmed
Thus ,
EP3 expression in the epidermis might contribute to a silencing of
skin inflammation in chronic - phase
SJS /
TEN . -
pubmed
Here , we describe a novel liposome - based subunit vaccine formulation for
tuberculosis (
TB ) based on
phosphatidylserine encapsulating two prominent TB antigens ,
Ag85B , and
ESAT-6 . -
pubmed
The postnatal presence of
human chorionic gonadotropin in
preterm infants and its potential inverse association with
retinopathy of prematurity . -
pubmed
We analyzed
hCG and
LH blood levels at 1 week and 4 weeks of age from 113 study
participants ( 60 without
ROP ; 53 with non - proliferative
ROP ) . -
pubmed
RESULTS : Similar levels of
hCG are found in
preterm infants at both 1 week and 4 weeks after birth . -
pubmed
Preterm
infants with non - proliferative
ROP , after adjusting for sex and gestational age , have 2.42 [ 95 % CI : 1.08 - 5.40 ] times the odds of having low
hCG at fourth week of age . -
pubmed
CONCLUSIONS : We found that
hCG is present postnatally in
preterm infants and that a
deficiency of hCG at 4 weeks of age is potentially associated with non - proliferative
ROP . -
pubmed
IL-8 gene locus is associated with risk , severity and 28 - day mortality of
sepsis in a Chinese population . -
pubmed
Interleukin ( IL )- 8 has been reported to be associated with the progression of
sepsis . -
pubmed
Recent studies have explored the relationship between the
IL-8 - 251 A / T polymorphism and
sepsis risk . -
pubmed
This study evaluated the association between the
IL-8 - 251 A / T polymorphism and
sepsis susceptibility in a Chinese Han population . -
pubmed
This study showed that the
IL-8 - 251 A / T polymorphism was associated with a decreased risk of
sepsis . -
pubmed
The
IL-8 - 251 A / T polymorphism was also related to the severity and 28 - day mortality of
sepsis . -
pubmed
The
IL-8 - 251 A / T polymorphism is associated with a decreased risk of
sepsis . -
pubmed
Creutzfeldt - Jakob disease (
CJD ) is characterized by a rapidly progressive
dementia often accompanied by
myoclonus and other signs of
brain dysfunction , relying on the conversion of the normal cellular form of the
prion protein (
PrPC ) to a misfolded form (
PrPSc ) . -
pubmed
Moreover , its two important executioners , the
gasdermin D (
GSDMD ) and
gasdermin E (
GSDME ) , and the functions and mechanisms of them in the regulation in
cancer therapy were focused on . -
pubmed
Clinical presentation and differential splicing of
SRSF2 ,
U2AF1 and
SF3B1 mutations in patients with
acute myeloid leukemia . -
pubmed
Oral
prednisolone was administered on day 33 then
fever subsided with dramatically clinical improvement ( decreased
CRP and resolution of lung consolidation ) . -
pubmed
Together , these results suggest that the effect of
RES in treatment of
DN may involve
AMPK alpha /
mTOR - mediated autophagy . -
pubmed
Recent highlights include use of antibody - dependent cellular cytotoxicity - sensitizing
CD4 - induced mimetic compounds , novel V1V2 immunogens , passive transfer studies , and vaccine regimens that successfully elicited Fc - mediated responses and were reported to decrease risk of
infection in challenge studies in NHPs . -
pubmed
New studies continue to highlight the importance of Fc - mediated antibody responses as correlates of decreased risk of
infection and suggest enhanced phagocytosis is a potential mechanism of reduced risk of
infection associated with
human IgG3 responses . -
pubmed
Parkinson ' s disease (
PD ) is the most frequent of all
Lewy body diseases , a family of progressive
neurodegenerative disorders characterized by intra - neuronal cytoplasmic inclusions of
alpha - synuclein . -
pubmed
[ A case of
Alexander disease presented with
dystonia of lower limb and decreased dopaminergic uptake in
dopamine transporter scintigraphy ] . -
pubmed
Soluble forms of
PD - L1 and
PD-1 as prognostic and predictive markers of
sunitinib efficacy in
patients with metastatic
clear cell renal cell carcinoma . -
pubmed
Metastatic clear cell renal cell carcinoma (
mccRCC ) benefits from several treatment options in the first - line setting with
VEGFR inhibitors and/or immunotherapy including anti -
PD - L1 or anti -
PD1 agents . -
pubmed
Therefore , we evaluated soluble forms of
PD - L1 (
sPD - L1 ) and
PD-1 (
sPD-1 ) in
mccRCC patients . -
pubmed
The levels of
sPD - L1 and
sPD-1 were evaluated from plasma samples of
mccRCC patients before they received a first - line treatment ( T0 ) by the
VEGFR inhibitor
sunitinib ( 50
patients ) or by the anti -
VEGF bevacizumab ( 37
patients ) . -
pubmed
mccRCC patients with high plasmatic levels of
sPD - L1 or
sPD-1 are poor responders to
sunitinib . -
pubmed
Reduced numbers of T cells with
Fc receptors for
IgG ( TG cells ) are present in blood samples of
patients with
respiratory allergic disease , mainly those with severe symptoms . -
pubmed
Dog
mastocytoma cells produce
transforming growth factor beta 1 . -
pubmed
We report here the constitutive production of
TGF beta 1 by four
dog mastocytoma cell lines . -
pubmed
Quantitation by bioassay revealed baseline
TGF beta secretion of approximately 1 ng/10(6 ) cells over 48 h. Stimulation of
mastocytoma cells with
phorbol ester increased the rate of release of
TGF beta 1 , most markedly in the first 30 min after stimulation , without increasing TGF beta 1 mRNA . -
pubmed
Dog mastocytoma cells produced
TGF beta 1 primarily in a latent form , inactive until treated with acid . -
pubmed
Both pure
TGF beta 1 and
TGF beta - containing mastocytoma cell - conditioned media inhibited mitogenesis and proliferation in
dog mastocytoma cell lines , suggesting that mast cell
tumor lines would not grow preferentially based on their ability to produce
TGF beta . -
pubmed
The growth promoting effect of several hormones and
growth factors on two
human colon tumor cell lines (
Caco-2 and
SW 48 ) was studied using six different chemically defined serum - free media ( SFM ) . -
pubmed
The method is demonstrated by localization of
insulin - like growth factor II (
IGF - II ) mRNA in
human intracranial tumours and foetal brain . -
pubmed
Five of 10
meningiomas expressed
IGF - II mRNA to an extent of 1 % of their
tumour cells and two of three
pituitary adenomas exhibited a less than 0.2 %
IGF - II mRNA - positive cell population . -
pubmed
IGF - II may be important in the progression and/or maintenance of these
tumours . -
pubmed
Tissue levels of
adenosine triphosphate ( a major tissue energy store ) ,
superoxide dismutase ( a major defense against free radicals ) ,
xanthine oxidase ( an enzymatic source of free radicals ) , and
edema were measured . -
pubmed
Expression of
c - fos in parietal endoderm , amnion and differentiating
F9 teratocarcinoma cells . -
pubmed
Among these activities the production of
proteases could obviously influence
tumor cell detachment and migration from the primary . -
pubmed
We have evaluated the expression of
plasminogen activator (
PA ) in different types of
murine tumors with differing immunogenic capacity . -
pubmed
In
TAM from all
tumors studied the expression of
PA was markedly greater than that of resident peritoneal macrophages . -
pubmed
Hypomyelination in
border disease : the roles of thyroid hormones ,
growth hormone , and
virus infection of the CNS . -
pubmed
Immunoglobulin allotypes in
patients with
giant cell arteritis and
polymyalgia rheumatica . -
pubmed
We conclude that some patients with
PPS have in the serum high titers of
IgM anti - PV antibodies , implying an ongoing antibody response to a viral
antigen . -
pubmed
Structure - function analysis of
human glucose-6 - phosphatase , the enzyme deficient in
glycogen storage disease type 1a . -
pubmed
Glucose-6 - phosphatase (
G6Pase ) is the enzyme deficient in
glycogen storage disease type 1a , an
autosomal recessive disorder . -
pubmed
We have previously identified six mutations in the
G6Pase gene of
glycogen storage disease type 1a patients and demonstrated that these mutations abolished or greatly reduced enzymatic activity of
G6Pase , a hydrophobic protein of 357 amino acids . -
pubmed
Refining the localization of the
PKD2 locus on chromosome 4q by linkage analysis in Spanish families with
autosomal dominant polycystic kidney disease type 2 . -
pubmed
To test this possibility , we introduced a transgene directing lymphoid expression of
IL-7 into
nude mice and found that it substantially alleviates the block in T cell maturation caused by the
thymic defect . -
pubmed
Modular organization of
human extrastriate visual cortex : evidence from
cytochrome oxidase pattern in normal and
macular degeneration cases . -
pubmed
The pattern of
cytochrome oxidase activity in these visual areas is now described in a normal case and in a case of age - related
bilateral macular degeneration . -
pubmed
PURPOSE : We retrospectively evaluated the ability of
human chorionic gonadotropin (
HCG ) to make the nonpalpable
cryptorchid testis become palpable and promote testicular descent . -
pubmed
NK cells induced both
necrosis and apoptosis in
cell lines insensitive to NK cells in the presence of an antibody against the
major histocompatibility complex class I ( antibody - dependent cell - mediated cytotoxicity , ADCC ) . -
pubmed
Hypercellularity , increase in number and morphological alterations of megakaryocytes , raised
reticulin content , mild
plasmacytosis and frequent presence of reactive lymphoid aggregates are features suggestive , thought not diagnostic , for
HIV infection on BMB . -
pubmed
Colosplenic
fistula in a
patient treated with
interleukin-2 for
malignant melanoma . -
pubmed
Interleukin-2 (
IL-2 ) therapy often causes gastrointestinal side effects and at least 8 cases of
bowel perforation have been reported . -
pubmed
Total lymphocyte and
CD4(+)-cell counts for
AIDS patients ( 1,451 + /- 811 cells / microliters , P & lt ; 0.001 , and 238 + /- 392 cells / microliters , P & lt ; 0.0001 , respectively and asymptomatic
patients ( 2,393 + /- 664 cells / microliters , P & gt ; 0.05 , and 784 + /- 475 cells / microliters , P & lt ; 0.001 , respectively ) were lower than those observed for healthy subjects ( 2,596 + /- 631 cells / microliters and 1,120 + /- 296 cells / microliters , respectively ) . -
pubmed
The levels of
beta 2 - microglobulin and
IgA in serum were significantly elevated in
patients with
AIDS ( 5.7 + /- 3.6mg / liter , P & lt ; 0.001 , and 541 + /- 265 mg / dl , P & lt ; 0.0002 , respectively ) and asymptomatic infected subjects ( 3.4 + /- 2.1 mg / liter , P = 0.001 , and 436 + /- 216 mg / dl , P & lt ; 0.0001 , respectively ) compared with the levels in healthy subjects ( 2.2 + /- 0.7 mg / liter and 204 + /- 113 mg / dl , respectively ) . -
pubmed
Nonstatistically significant differences ( P & gt ; 0.05 ) for concentrations of
p24 antigen between asymptomatic infected
patients ( 29 + /- 13 pg / ml ) and
AIDS patients ( 40 + /- 23 pg / ml ) were observed . -
pubmed
Total lymphocyte counts of 1,750 cells / microliters or less ,
CD4 counts of 200 cells / microliters or less ,
beta 2 - microglobulin concentrations in serum of 4 mg / liter or higher , concentrations of
IgA in serum of 450 mg / dl or higher , and the presence in serum of
p24 antigen were correlated with elevated risks for developing
AIDS . -
pubmed
Monitoring both total lymphocytes and
beta 2 - microglobulin identified 91 % of the
AIDS patients ; these assays may allow reductions in the annual number of
CD4(+)-cell evaluations and the costs associated with monitoring both total lymphocytes and
beta 2 - microglobulin identified 91 % of the
AIDS patients ; these assays may allow reductions in the annual number of
CD4(+)-cell evaluations and the costs associated with monitoring the immune status of
HIV - positive patients . -
pubmed
In the Born test
4 - chlorophenylethenecarboxamidoxime ( 21 ) was most active and inhibited the blood
platelet aggregation induced by
collagen with an IC50 = 3 microM. -
pubmed
The authors hypothesized that experimental
human Wilms ' tumors would display a vascular architecture similar to
retinal diseases that are driven by
vascular endothelial growth factor (
VEGF ) . -
pubmed
CONCLUSIONS : Vascular architecture of
Wilms ' tumor displays the specific features previously described in diseases of the retina , which have been shown to be driven by
VEGF , suggesting that neoangiogenesis in this model is also
VEGF driven . -
pubmed
Bilateral simultaneous
retinal arteriolar obstruction in a
child with
hemoglobin SS
sickle cell disease . -
pubmed
Elevated plasma
thrombopoietin levels and
thrombosis in
essential thrombocythemia : a preliminary report . -
pubmed
[ Diffuse
large B - cell lymphoma expressing cytoplasmic IgM and kappa in a
patient with
lambda - type primary macroglobulinemia ] . -
pubmed
A biopsy sample was obtained by exploratory laparotomy , and from this a diagnosis of
diffuse large cell lymphoma (
DLCL ) expressing
cytoplasmic IgM / kappa was made . -
pubmed
There was no difference in the plasma monoclonal
IgM / lambda level before and during the course of
DLCL . -
pubmed
First , those identifiable as screen - positive for both
Down syndrome and an open
neural tube defect (
ONTD ) with elevated MS -
AFP , grossly elevated
hCG , low / normal uE3 , and probably elevated
INH - A. -
pubmed
Pregnancies in the second group are identifiable as screen - positive for
trisomy 18 with low / normal MS -
AFP , and very low
hCG , uE3 and
INH - A. -
pubmed
Triploid pregnancies with high maternal serum
hCG nearly always show a placenta with partial mole ( 25/27 or 93 % ) , a high frequency of
ONTDs or
ventral wall defects (
VWDs ) ( 8/28 or 29 % ) and have either an XXX or XXY karyotype ( observed ratio 6:10 , respectively ) . -
pubmed
Low
hCG is infrequently associated with a
molar placenta ( 1/11 or 9 % ) , does not appear to be associated with
ONTDs or
VWDs ( 0/29 or 0 % ) , and shows an excess of XXX over XXY karyotypes ( observed ratio 17:2 ) . -
pubmed
There were 16 cases with either a
molar placenta , an
ONTD or a
VWD that received the MS -
AFP and
hCG tests . -
pubmed
In addition , all 31 cases that received MS -
AFP ,
hCG , uE3 ( and where available INH - A ) were screen - positive for either
Down syndrome or
trisomy 18 . -
pubmed
P - glycoprotein (
P - gp)/multi - drug resistance 1 (
MDR1 ) gene is recognized to be , at least in part , responsible for the refractoriness to chemotherapy of
leukemia . -
pubmed
However , recent reports have clarified that
early growth response 1 gene (
Egr1 ) positively regulates
MDR1 transcription , while
Wilms ' tumor suppressor gene (
WT1 ) does negative regulation of
MDR1 gene expression in
12 - O - tetradecanoylphorbol-13 - acetate treated K562 cells . -
pubmed
Our study of mRNA expression profile of
Egr1 ,
WT1 and
MDR1 in fresh
AML samples demonstrated that there are disease - specific patterns . -
pubmed
mRNA expression of
MDR1 was frequent in
AML M1 and t(8;21 )
AML cells , in which the expression level was highest in
AML M1 and was low in
monocytic leukemia ( M4 and
M5 ) . -
pubmed
By liquid culture of
leukemia cell lines and fresh
AML cells with the addition of
all - trans retinoic acid (
ATRA ) , modulation of
P - gp /
MDR1 and
Egr1 was observed and the pattern of modulation was divided into four groups : ( 1 ) blastic
AML type , in which distinct expression of
P - gp /
MDR1 and
CD34 was not influenced by
ATRA ; ( 2 ) t(8;21)
AML type , in which P - gp /
MDR1 expression was augmented by
ATRA , while
CD34 was kept high ; ( 3 )
AML M3 type , in which P - gp /
MDR1 expression was reduced with granulocytic differentiation by
ATRA ; ( 4 ) monocytic
AML type , in which P - gp /
MDR1 expression was augmented by
ATRA , while
CD34 expression decreased , and strong
Egr1 expression was downregulated just prior to the augmentation of P - gp /
MDR1 expression . -
pubmed
However , P - gp /
MDR1 expression augmented by
ATRA , which was observed in monocytic
AML , was recognized as a functional molecule of mature monocyte / macrophage , because
CD34 expression decreased and
CD13 expression increased by
ATRA . -
pubmed
Finally , expression of
P - gp /
MDR1 in
monocytic leukemia , which was functionally confirmed by
Rh123 efflux study , was thought to be closely related to the characteristic modulation of
Egr1 expression by
ATRA . -
pubmed
Coincidence of pro- and anti - inflammatory responses in the early phase of severe
sepsis : Longitudinal study of
mononuclear histocompatibility leukocyte antigen - DR expression ,
procalcitonin ,
C - reactive protein , and changes in T - cell subsets in septic and postoperative
patients . -
pubmed
OBJECTIVE : To determine the time course of
histocompatibility leukocyte antigen ( HLA )- DR expression in peripheral blood mononuclear cells and their relationship to markers of
inflammation , organ function , and outcome during severe
sepsis . -
pubmed
MEASUREMENTS AND MAIN RESULTS : Despite a relative
lymphopenia , absolute lymphocyte counts and
CD4+/
CD8 + T - cell ratio in septic
patients were significantly elevated above normal . -
pubmed
Particularly ,
CD4 + and
CD8 + T - cell counts in nonsurvivors of
sepsis were approximately twice as high as those of survivors . -
pubmed
Significantly decreased monocytic
HLA - DR expression was observed in both survivors and nonsurvivors at the onset of severe
sepsis . -
pubmed
Percentages of
HLA - DR+ lymphocytes , however , were significantly increased during
sepsis , especially in nonsurvivors . -
pubmed
Whereas survivors of
sepsis showed a continuous recovery of monocytic
HLA - DR expression to & gt;or=70 % within 10 days , nonsurvivors were characterized by a second decrease in monocytic
HLA - DR expression after day 7 or a permanent suppression ( & lt;40 % ) . -
pubmed
CONCLUSIONS : Decreases in monocytic
HLA - DR expression occurred simultaneously with signs of
hyperinflammation as early as the onset of severe
sepsis and usually developed in opposite directions than inflammatory markers and
sepsis severity scores . -
pubmed
TNF and
TNF receptor polymorphisms in Korean
Behcet ' s disease patients . -
pubmed
The serum level of
tumor necrosis factor (
TNF ) is elevated in
patients with active
BD , and its production is elevated in monocytes and in the gamma delta T cells of
BD patients . -
pubmed
A dramatic response to
anti - TNF - alpha antibody treatment further supports the role of
TNF in
BD . -
pubmed
In this study , we investigated genetic polymorphisms of
TNF alpha -308 G / A ,
TNF beta +252 G / A , and
TNFR2 196 R / M in 94 Korean
BD patients and age- and sex - matched healthy controls to investigate the role of
TNF and
TNF receptor polymorphisms in
BD . -
pubmed
In conclusion , this study found no differences of
TNF alpha -308 G / A ,
TNF beta +252 G / A or of the
TNFR2 196R / M polymorphisms in Korean
BD patients versus healthy controls . -
pubmed
These findings suggest that the role of
TNF in
BD is not genetically determined , but can be functionally explained . -
pubmed
Characterization of
MTHFR ,
GSTM1 ,
GSTT1 ,
GSTP1 , and
CYP1A1 genotypes in childhood
acute leukemia . -
pubmed
The role of
methylenetetrahydrofolate reductase (
MTHFR C677 T ) ,
glutathione S - transferases (
GSTM1 and
GSTT1 null ,
GSTP1 Ile105Val ) , and
cytochromes p450 (
CYP1A1 * 2A ) genotypes in the etiology of
childhood leukemia was simultaneously investigated . -
pubmed
The frequency of
MTHFR genotype was insignificantly higher in
ALL ( 7.7 % ) and
ANLL ( 6.3 % ) than in controls ( 4.4 % ) . -
pubmed
Equal distribution of the
GSTM1 null genotype was detected between
ALL patients and controls ( 55 % ) , while its incidence was slightly higher in
ANLL patients ( 61.3 % ) . -
pubmed
Although
GSTT1 null genotype was insignificantly lower in
ALL patients ( 20.9 % ) than controls ( 22.7 % ) , it was significantly underrepresented in
ANLL patients ( 6.5 % ) ( P = 0.05 , OR 0.24 , 95 % CI 0.05 - 1.03 ) . -
pubmed
The homozygous frequency of
GSTP1 genotype did not differ significantly between groups of
ALL ( 3.7 % ) ,
ANLL patients ( 9.1 % ) and controls ( 4.9 % ) . -
pubmed
Homozygous
CYP1A1 * 2A genotype was underrepresented in
ALL patients ( 1 % ) as compared to control ( 4.8 % ) but the differences did not reach to statistical significance ( OR 0.21 ; 95 % CI 0.03 - 1.72 ) . -
pubmed
These results suggested that there are no significant associations between the studied genotypes and the risk of developing either form of
acute leukemia except
GSTT1 null and homozygosity for
CYP1A1 genotypes that may play protective roles in the development of
ANLL in Turkish children . -
pubmed
Changes in the number of
CD80(+ ) ,
CD86(+ ) , and
CD28(+ ) peripheral blood lymphocytes have prognostic value in
melanoma patients . -
pubmed
Our aim was to evaluate whether the number of circulating lymphocytes expressing
costimulatory molecules can be associated with
melanoma prognosis . -
pubmed
We determined the concentration of peripheral blood lymphocytes , which expressed the
CD80 /
CD86 or
CD28 /
CTLA-4 molecules , in 38
patients with
cutaneous melanoma and 27 controls . -
pubmed
There was a lower number of
CD3(+)
CD8(+)
CD28(+ ) cells , as well as a higher
CD3(+)
CD8(+)/
CD3(+)
CD8(+)
CD28(+ ) cell ratio , in
melanoma patients than in controls . -
pubmed
Melanoma patients with thinner
tumors and those surviving revealed an increase of
CD19(+)
CD80(+ ) and
CD19(+)
CD80(+)
CD86(+ ) cells , as well as a higher concentration of
CD3(+)
CD4(+)
CD28(+ ) cells . -
pubmed
CD80(+ ) B cells and a low
CD8 suppressor / cytolytic cell ratio correlate with a good prognosis in
melanoma . -
pubmed
Our findings support our conclusion that
CD80(+ ) B cells may be important antigen presenting cells that can contribute to an antimelanoma immune response and are candidates to be monitored in
melanoma patients . -
pubmed
We have shown previously that
interferon regulatory factor 7 (
IRF7 ) , a multifunctional protein intimately involved in latent
Epstein - Barr virus ( EBV ) infection , is induced as well as activated by
EBV latent membrane protein 1 (
LMP1 ) , the principal
EBV oncoprotein . -
pubmed
[
ACTH and
cortisone in the treatment of
chronic lymphatic leukemia ] . -
pubmed
Effect of
phosphodiesterase-5 inhibitor ,
sildenafil (
Viagra ) , in animal models of
airways disease . -
pubmed
Phosphodiesterase ( PDE )- 5 degrades
guanosine 3 ' , 5'cyclic monophosphate (
cGMP ) and its inhibitor
sildenafil citrate (
Viagra ) treats
erectile dysfunction by smooth muscle relaxation through elevated
cGMP . -
pubmed
These antiinflammatory actions of
sildenafil in
guinea pig models suggest that
PDE5 inhibitors may have potential in treating
airways disease . -
pubmed
18 months later , the
cutaneous lesions recurred ,
angiotensin converting enzyme (
ACE ) serum levels were increased and a chest X - ray demonstrated
pulmonary involvement . -
pubmed
Nuclear factor - kappa B expression in alveolar macrophages of mechanically ventilated neonates with
respiratory distress syndrome . -
pubmed
There were close correlations between the expression of
NF - kappaB and levels of
IL-1beta ( r = 0.78 , p & lt ; 0.01 ) , and
IL-8 ( r = 0.81 , p & lt ; 0.01 ) in
AA . -
pubmed
CONCLUSION : There were alterations in
NF - kappaB activity in the AM of mechanically ventilated preterm neonates with
RDS , mediated by decreased synthesis and increased degradation of
IkappaB. -
pubmed
A novel point mutation of the
RET protooncogene involving the second intracellular
tyrosine kinase domain in a family with
medullary thyroid carcinoma . -
pubmed
These
genetic syndromes are associated with germline - activating mutations of the
RET protooncogene , a
cell surface tyrosine kinase receptor , which is believed to modulate specific intracellular signaling pathways involved in the regulation of C cell proliferation and apoptosis . -
pubmed
Here , we describe a novel missense mutation of the
RET protooncogene that substitutes
arginine for
proline at codon 912 of the
intracellular tyrosine kinase domain in a family with
medullary thyroid carcinoma . -
pubmed
However , this rise does seem to impair the value of
PSA in
patients with undiagnosed
prostate cancer . -
pubmed
Aberrant transcription of
FHIT gene in
intrahepatic cholangiocellular carcinomas induced by
N - nitrosobis ( 2 - oxopropyl ) amine in
hamsters . -
pubmed
Aberrant transcription of the
fragile histidine triad (
FHIT ) gene was investigated in
intrahepatic cholangiocellular carcinomas ( ICCs ) induced by
N - nitrosobis ( 2 - oxopropyl ) amine (
BOP ) in female
Syrian golden hamsters . -
pubmed
These results suggest that alteration of the
FHIT gene may play a role in a small fraction of
ICCs induced by
BOP in the
hamster . -
pubmed
In the current study , we further analyzed the signaling pathways involved in
PCD mediated by
MAb 1D5 . -
pubmed
After the third chemotherapy session , metastases had completely disappeared , the serum levels of
alpha - fetoprotein and
human chorionic gonadotropin beta subunit had normalized and the
dermatomyositis symptoms had improved . -
pubmed
Several studies suggest that the
VEGF receptor pathway and the
Tie-2 pathway are independent and essential mediators of angiogenesis , leading to the hypothesis that simultaneous interference with both pathways should result in additive effects in
tumor growth . -
pubmed
In a
human melanoma xenograft
mouse model , we could show that blockade of both
VEGF - R2 and
Tie-2 pathways or the
VEGF receptor pathway alone resulted in a significant inhibition of
tumor growth and
tumor angiogenesis ( 92.2 % and 74.4 % ) . -
pubmed
The novel
human oncogene
hWAPL is associated with
uterine cervical cancer . -
pubmed
No evidence existed to suggest any association between
CYP1A2 and the onset of
PD ( P=0.08 ) . -
pubmed
OBJECTIVE : To observe whether
human papillomavirus 16 (
HPV16 )
E6 - specific small interfering RNAs ( siRNAs ) can be employed to inhibit the growth of
cervical cancer cell line , and to investigate the associated mechanism . -
pubmed
Acceleration of
wound healing in
traumatic ulcers by absorbable
collagen sponge containing recombinant
basic fibroblast growth factor . -
pubmed
The objective of this study was to examine the safety and efficacy of topical application of recombinant
basic fibroblast growth factor loaded on a kind of absorbable
collagen sponge (
rbFGF / ACS ) in
patients with chronic
traumatic ulcers . -
pubmed
Compared with the placebo group ,
rbFGF / ACS significantly increased the incidence of complete
wound closure by 68 % ( 90.0 % versus 53.6 % , P = 0.0019 ) after 3 weeks and shortened the time to achieve complete
wound closure by 24 % ( 10.6 days versus 13.9 days , P = 0.0171 ) . -
pubmed
rbFGF / ACS significantly increased the incidence of complete
wound closure , shortened the complete healing time and improved the healing quality of
chronic traumatic ulcers . -
pubmed
It was not significantly associated with blood pressure ,
hypertension , serum total or high density lipoprotein
cholesterol , body mass ,
diabetes ,
gout ,
osteoporosis ,
cardiovascular disease , smoking ,
caffeine use , or taking
calcium channel blockers or anticholesterol medications . -
pubmed
Predictable removal of
anticardiolipin antibody by therapeutic plasma exchange ( TPE ) in
catastrophic antiphospholipid antibody syndrome (
CAPS ) . -
pubmed
We report predictive and effective removal of pathological
anticardiolipin antibody ( aCL AB ) in a patient with
CAPS . -
pubmed
Circulating
dickkopf-1 and radiological progression in
patients with early
rheumatoid arthritis treated with etanercept . -
pubmed
OBJECTIVE :
Dickkopf-1 (
Dkk-1 ) regulates bone remodeling in animal models of
inflammatory arthritis , but its role in
patients with
rheumatoid arthritis (
RA ) remains unclear . -
pubmed
METHODS : Baseline circulating
Dkk-1 was measured in 113
patients with
RA ( & lt ; 3 yrs ) who received etanercept ( 10 or 25 mg twice / week , n = 63 ) or
methotrexate alone ( n = 40 ) for 1 year . -
pubmed
RESULTS : Increased
Dkk-1 was associated with a higher risk of progression of
bone erosion , independently of age , sex , baseline radiological damage ,
C - reactive protein , and disease activity in
patients treated with etanercept . -
pubmed
CONCLUSION :
Dkk-1 may be an important mediator of
bone erosion in
patients with
RA . -
pubmed
FGFR1 that is normally associated with activated nonparenchymal cells appears ectopically in
hepatoma cells . -
pubmed
Ectopic expression and chronic activity of
FGFR1 in hepatocytes accelerates
diethylnitrosamine (
DEN)-initiated hepatocarcinogenesis by driving unrestrained cell proliferation and
tumor angiogenesis . -
pubmed
Here we ask whether
FGFR4 plays a role in progression of
hepatocellular carcinoma (
HCC ) . -
pubmed
We report that although spontaneous
HCC was not detected in livers of
FGFR4 - deficient
mice , the ablation of
FGFR4 accelerated
DEN - induced
hepatocarcinogenesis . -
pubmed
In contrast to
FGFR1 that induced a strong mitogenic response and depressed rate of cell death in
hepatoma cells ,
FGFR4 failed to induce a mitogenic response and increased the rate of cell death . -
pubmed
These results suggest that in contrast to ectopic
FGFR1 that is a strong promoter of
hepatoma , resident
FGFR4 that mediates differentiated hepatocyte metabolic functions also serves to suppress
hepatoma progression . -
pubmed
BACKGROUND : A recent meta - analysis study showed that post - operative adjuvant chemotherapy with
UFT , an oral combination drug composed of
tegafur [ prodrug of
5 - fluorouracil (
5 - FU ) ] and
uracil [ inhibitor of
dihydropyrimidine dehydrogenase (
DPD ) ] was associated with improved survival in
patients with
lung adenocarcinomas , but not in those with
lung squamous cell carcinomas . -
pubmed
METHODS : We investigated the
5 - FU - related gene expression levels of
thymidylate synthase (
TS ) ,
DPD ,
thymidine phosphorylase (
TP ) and
orotate phosphoribosyl transferase (
OPRT ) in resected
tumor specimens from 51
patients with
adenocarcinomas and 47 with
squamous cell carcinomas using quantitative reverse transcription - PCR , and compared those levels between the two histological types . -
pubmed
RESULTS : The relative gene expression values of
TS ,
TP and
OPRT were significantly lower in
adenocarcinomas compared with
squamous cell carcinomas , 1.60 + /- 0.86 versus 4.33 + /- 3.40 ( P & lt ; 0.001 ) , 0.84 + /- 0.52 versus 2.27 + /- 1.16 ( P = 0.006 ) and 9.59 + /- 6.30 versus 16.94 + /- 12.04 ( P & lt ; 0.001 ) , respectively . -
pubmed
The relative gene expression value of
DPD was significantly greater in
adenocarcinomas than those in
squamous cell carcinomas , 2.33 + /- 1.22 versus 1.50 + /- 1.20 ( P = 0.01 ) . -
pubmed
Lower expressions of
TS and
TP were observed more in
adenocarcinomas ( 89.8 % ) than in
squamous cell carcinomas ( 48.9 % ) ( P & lt ; 0.001 ) . -
pubmed
Effector ( Teff ) and regulatory ( Treg ) T cells produce
cytokines that balance immunity and immunopathology at sites of
infection . -
pubmed
Potential relevance of cerebrospinal fluid and serum levels and intrathecal synthesis of active
matrix metalloproteinase-2 (
MMP-2 ) as markers of disease remission in
patients with
multiple sclerosis . -
pubmed
BACKGROUND : Little is known about the involvement of
matrix metalloproteinase-2 (
MMP-2 ) and its tissue inhibitor
TIMP-2 in
multiple sclerosis (
MS ) . -
pubmed
OBJECTIVE : To elucidate the actual implication of
MMP-2 and
TIMP-2 in
MS . -
pubmed
METHODS : Cerebrospinal fluid ( CSF ) and serum levels of active
MMP-2 and
TIMP-2 were measured by activity assay system and ELISA , respectively , in 67
patients with relapsing - remitting
MS (
RRMS ) , categorized according clinical and magnetic resonance imaging ( MRI ) , and in 129 controls . -
pubmed
RESULTS : Cerebrospinal fluid and serum active
MMP-2 /
TIMP-2 ratio mean values and an intrathecal active
MMP-2 production were more increased in
RRMS than in non - inflammatory conditions ( P & lt ; 0.001 , P & lt ; 0.05 , and P & lt ; 0.0001 , respectively ) and in MRI inactive than in MRI active
RRMS ( P & lt ; 0.02 , P & lt ; 0.01 and P & lt ; 0.001 , respectively ) . -
pubmed
An intrathecal synthesis of active
MMP-2 was more frequent in
RRMS than in
inflammatory disorders ( P & lt ; 0.01 ) . -
pubmed
CONCLUSION : These findings suggest a potential role for
MMP-2 activity in the termination of
MS neuroinflammation related to remission of the disease and seem to indicate that serum
MMP-2 /
TIMP-2 ratio may represent a useful biomarker for monitoring MS recovery phase . -
pubmed
Antibodies targeting
hepatoma - derived growth factor as a novel strategy in treating
lung cancer . -
pubmed
Hepatoma - derived growth factor (
HDGF ) is overexpressed in
lung cancer and the overexpression correlates with aggressive biological behaviors and poor clinical outcomes . -
pubmed
We developed anti -
HDGF monoclonal antibodies and tested their antitumor activity in
lung cancer xenograft models . -
pubmed
We also determined biological effects in
tumors treated with the antibody alone or in combination with bevacizumab /
avastin ( an anti -
vascular endothelial growth factor antibody ) and/or
gemcitabine ( a chemotherapeutic agent ) . -
pubmed
We found the anti -
HDGF was effective to inhibit
tumor growth in non - small cell lung cancer xenograft models . -
pubmed
In the
A549 model , compared with control
IgG ,
tumor growth was substantially inhibited in animals treated with anti -
HDGF antibodies , particularly
HDGF - C1 ( P = 0.002 ) and
HDGF - H3 ( P = 0.005 ) . -
pubmed
When
HDGF - H3 was combined with either bevacizumab or
gemcitabine , we observed enhanced
tumor growth inhibition , particularly when the three agents were used together . -
pubmed
HDGF - H3 - treated
tumors exhibited significant reduction of microvessel density with a pattern distinctive from the microvessel reduction pattern observed in bevacizumab - treated
tumors . -
pubmed
HDGF - H3 - treated but not bevacizumab - treated
tumors also showed a significant increase of apoptosis . -
pubmed
Interestingly , many of the apoptotic cells in
HDGF - H3 - treated
tumors are stroma cells , suggesting that the mechanism of the antitumor activity is , at least in part , through disrupting formation of
tumor - stroma structures . -
pubmed
Our results show that
HDGF is a novel therapeutic target for
lung cancer and can be effectively targeted by an antibody - based approach . -
pubmed
Brain natriuretic peptide in
chronic thromboembolic pulmonary hypertension . -
pubmed
Rashes and visceral involvement have started to be reported more often , especially with
tumor necrosis factor antagonists . -
pubmed
OUTCOMES :
Protein - caloric malnutrition ( defined as the occurrence of 1 of the following : loss of body weight & gt ; 5 % in 1 month or 7.5 % in 3 months or body mass index & lt ; 20 kg / m(2 ) with
serum albumin level & lt ; 3.2 g / dL and normal
C - reactive protein level [ & lt;0.5 mg / dL ] ) , dialysis , death , or the composite outcome of dialysis and death . -
pubmed
The induction of vessel - like networks is dependent from proper glycosylation of collagens and does not occur on osteogenic ECMs if deglycosylated by -galactosidase or on less glycosylated ECMs derived from preosteoblasts and normal fibroblasts , while is sustained on ECM from
osteogenesis imperfecta fibroblasts only when their mutation is associated with over - glycosylation of
collagen type I. -
pubmed
Update on lipids and
C - reactive protein in acute and chronic
coronary heart disease . -
pubmed
Do
calcium channel blockers increase the diagnosis of
heart failure in
patients with
hypertension ? -
pubmed
In conclusion , suppression of
HAS2 activity may represent an early process of GC - induced
skin atrophy that precedes the suppression of collagens . -
pubmed
Genome - wide association studies have underscored the importance of the clustered
neuronal nicotinic acetylcholine receptor (
nAChR ) subunit genes with respect to
nicotine dependence as well as
lung cancer susceptibility . -
pubmed
Immunohistochemical staining was positive for
S-100 protein and
glial fibrillary acidic protein (
GFAP ) , and negative for
Melan - A. Interestingly , there was no histological evidence of
glaucoma . -
pubmed
Female
Beagle dogs ( 9 - 10 mo old ; 8.2 + - 0.2 kg body weight ) were fed 0 , 10 , 20 or 40 mg
astaxanthin daily and blood sampled on wk 0 , 6 , 12 , and 16 for assessing the following :
lymphoproliferation , leukocyte subpopulations , natural killer ( NK ) cell cytotoxicity , and concentrations of blood
astaxanthin ,
IgG ,
IgM and acute phase proteins . -
pubmed
Here , we examine the role of
beta - arrestin1 and
beta - arrestin2 in the pathobiology of
pulmonary fibrosis . -
pubmed
In the
bleomycin - induced
mouse lung fibrosis model , loss of either
beta - arrestin1 or
beta - arrestin2 resulted in protection from mortality , inhibition of matrix deposition , and protected lung function . -
pubmed
Furthermore , knockdown of
beta - arrestin2 in fibroblasts from
patients with
idiopathic pulmonary fibrosis attenuated the invasive phenotype . -
pubmed
These data implicate
beta - arrestins as mediators of fibroblast invasion and the development of
pulmonary fibrosis , and as a potential target for therapeutic intervention in
patients with
idiopathic pulmonary fibrosis . -
pubmed
Response to the high - dose
corticotrophin stimulation test depends on plasma
adrenocotropin hormone levels in
septic shock . -
pubmed
PURPOSE : The use of the high - dose
corticotrophin stimulation test ( HDCST ) as a guide to use low - dose
steroid therapy in
septic shock is controversial . -
pubmed
We evaluated the correlation of the response to the HDCST with plasma
ACTH levels in
patients with
septic shock . -
pubmed
METHODS : This is a retrospective review of 102
patients with
septic shock in which adrenal function was evaluated using the HDCST and plasma
ACTH levels were measured . -
pubmed
CONCLUSION :
Patients with
septic shock with higher plasma
ACTH values presented a subnormal response to the HDCST . -
pubmed
In response to an outbreak of
Crimean - Congo hemorrhagic fever in western Afghanistan , we measured
immunoglobulin G seroprevalence among household members and their animals . -
pubmed
The expression patterns and correlations of
claudin-6 ,
methy - CpG binding protein 2 ,
DNA methyltransferase 1 ,
histone deacetylase 1 ,
acetyl - histone H3 and
acetyl - histone H4 and their clinicopathological significance in
breast invasive ductal carcinomas . -
pubmed
BACKGROUND :
Claudin-6 is a candidate tumor suppressor gene in
breast cancer , and has been shown to be regulated by DNA methylation and histone modification in
breast cancer lines . -
pubmed
However , the expression of
claudin-6 in
breast invasive ductal carcinomas and correlation with clinical behavior or expression of other markers is unclear . -
pubmed
METHODS : We have investigated the expression of
claudin-6 ,
MeCP2 ,
HDAC1 ,
H3Ac and
H4Ac in 100 breast invasive ductal
carcinoma tissues and 22 mammary gland
fibroadenoma tissues using immunohistochemistry . -
pubmed
RESULTS :
Claudin-6 protein expression was reduced in breast invasive ductal
carcinomas ( P & lt ; 0.001 ) . -
pubmed
H3Ac expression was associated with
tumor size ( P = 0.044 ) and clinical stage of
cancers ( P = 0.034 ) . -
pubmed
CONCLUSIONS : Our results show that
claudin-6 protein is significantly down - regulated in
breast invasive ductal carcinomas and is an important correlate with lymphatic metastasis , but
claudin-6 down - regulation was not correlated with upregulation of the methylation associated proteins (
MeCP2 ,
DNMT1 ) or
histone modification associated proteins (
HDAC1 ,
H3Ac , H4Ac ) . -
pubmed
Interestingly , the expression of
MeCP2 was positively correlated with the expression of
H3Ac and
H3Ac protein expression was positively correlated with the expression of
H4Ac in breast invasive ductal
carcinoma VIRTUAL SLIDES : The virtual slide(s ) for this article can be found here : http://www.diagnosticpathology.diagnomx.eu/vs/4549669866581452 . -
pubmed
An overview of cutaneous vasculature , role of
alpha - adrenoreceptors , and a discussion of available medical therapies and treatment selection are also presented , including emerging topical options for diffuse and persistent facial
erythema of rosacea . -
pubmed
Vildagliptin selectively ameliorates
GLP-1 ,
GLUT4 ,
SREBP-1c mRNA levels and stimulates beta - cell proliferation resulting in improved
glucose homeostasis in
rats with
streptozotocin - induced
diabetes . -
pubmed
OBJECTIVE : Inhibitors of
dipeptidyl peptidase-4 (
DPP-4 ) , a key regulator of the actions of incretin hormones , exert antihyperglycemic effects in
type 2 diabetic patients . -
pubmed
A major unanswered question concerns the potential ability of
DPP-4 inhibition to have beneficial disease - modifying effects , specifically to attenuate loss of pancreatic beta - cell mass and function due to oxidative stress induced
inflammation . -
pubmed
Here , we investigated the effects of a potent and selective
DPP-4 inhibitor
vildagliptin on glycemic control , pancreatic beta - cell mass and function , genes and proteins expressions ,
tumor necrosis factor - alpha , and
nitric oxide in an n2 -
STZ diabetic model of
rat with defects in
insulin sensitivity and secretion . -
pubmed
CONCLUSION : These findings suggest that
DPP-4 inhibitors may offer long - lasting efficacy in the treatment of
diabetes mellitus by modifying the courses of the disease . -
pubmed
HIF-2alpha is stabilized in
von Hippel - Lindau ( VHL )- deficient renal cell carcinoma through mechanisms that require ongoing mRNA translation . -
pubmed
Rictor - associated
mTORC2 complex has been linked to maintaining
HIF-2alpha protein in the absence of
VHL ; however , the mechanisms remain to be elucidated . -
pubmed
Furthermore , we provide the first evidence that silencing of
p22 ( phox ) reduces
HIF-2alpha - dependent gene targeting in vitro and
tumor formation in vivo . -
pubmed
Glycemic Control among Pregnant
Diabetic Women on
Insulin Who Fasted During Ramadan . -
pubmed
The objective of this study was to determine the glycemic control in pregnant
diabetic women on
insulin who fasted during Ramadan . -
pubmed
RESULTS : Thirty seven
women opted to fast with 24 ( 64.9 % ) of them had
type 2 diabetes mellitus and 83.8 % of them required combined
insulin ( short- acting , intermediate - acting ) therapy . -
pubmed
CONCLUSION : the findings indicate that pregnant
diabetic women on
insulin were able to fast during Ramadan and that their glycemic control was improved during fasting period . -
pubmed
Clinical use of p - proteasome in discriminating
metastatic melanoma patients : comparative study with
LDH ,
MIA and
S100B protein . -
pubmed
The objective of this study was to compare the diagnostic and prognostic values of p - proteasome with three other
melanoma serological markers :
S100B protein ,
melanoma inhibitory activity protein (
MIA ) and
lactate dehydrogenase (
LDH ) in the plasma of 121
stage I - IV melanoma patients . -
pubmed
P - proteasome and
S100B were the most sensitive ( 58.1 % ) and p - proteasome and MIA the most specific ( 98.7 and 100 % ) in detecting
metastatic disease . -
pubmed
The syndrome of apparent mineralocorticoid excess (
AME ) is an
autosomal recessive disorder characterized by
hypertension ,
hypokalemia , low
renin , and
hypoaldosteronism . -
pubmed
We report three siblings - two female and one male - with the syndrome of apparent mineralocorticoid excess who presented with
hypertension ,
hypokalemia , low
renin , and low
aldosterone levels . -
pubmed
The addition of
spironolactone resulted in a
decrease in blood pressure , rise in serum
potassium and a gradual increase in
plasma renin activity in all three . -
pubmed
In this study , the genetic testing of those three siblings with the typical clinical features of
AME has detected missense mutation c.662C>T ( p. Arg208Cys ) in exon 3 of the
HSD11B2 gene in the homozygous state . -
pubmed
Urinary
steroid profile and molecular analysis confirmed the diagnosis of non - classic
congenital adrenal hyperplasia (
NCCAH ) due to
21 - hydroxylase deficiency . -
pubmed
Previous systematic reviews found higher prevalences of
anti - EBV antibodies in
MS patients compared to controls , but many studies have since been published , and there is a need to apply more rigorous systematic review methods . -
pubmed
METHODOLOGY / PRINCIPAL FINDINGS : We examined the link between
EBV and
MS by conducting a systematic review and meta - analysis of case - control and cohort studies that examined the prevalence of
anti - EBV antibodies in the serum of cases and controls . -
pubmed
The meta - analysis showed a significant OR for sero - positivity to
anti - EBNA IgG and
anti - VCA IgG in
MS cases ( 4.5 [ 95 % confidence interval ( CI ) 3.3 to 6.6 , p<0.00001 ] and 4.5 [ 95 % CI 2.8 to 7.2 , p<0.00001 ] respectively ) . -
pubmed
Soluble isoform of the
receptor for advanced glycation end products as a biomarker for
postoperative respiratory failure after cardiac surgery . -
pubmed
We measured the serum levels of the soluble isoform of the
receptor for advanced glycation end products (
sRAGE ) , and we studied its association with postoperative
respiratory failure . -
pubmed
Receiver operating characteristic curve analysis demonstrated that postoperative
sRAGE had a predictive performance with area under the curve of 0.81 ( 95 % confidence interval 0.71 - 0.88 ) for postoperative
respiratory failure , defined as prolonged mechanical ventilation & gt;3 days . -
pubmed
CONCLUSIONS : Serum
sRAGE levels elevated immediately after cardiac surgery , and the range of elevation was associated with the morbidity of postoperative
respiratory failure . -
pubmed
Early postoperative
sRAGE levels appear to be linked to cardiopulmonary bypass , and may have predictive performance for postoperative
respiratory failure ; however , large - scale validation studies are needed . -
pubmed
As
neurodegenerative diseases are associated with
inflammation we determined if
clenbuterol could suppress
NFkappaB activation that occurs in response to an inflammatory stimulus . -
pubmed
Norovirus triggered microbiota - driven mucosal
inflammation in
interleukin 10 - deficient
mice . -
pubmed
In this study , the influence of murine
norovirus ( MNV ) infection on clinical , histopathological , and immunological features of
mucosal inflammation in the
IL10 - deficient (
Il10 )
mouse model of
inflammatory bowel disease was examined . -
pubmed
METHODS : C57BL/6J and C3H / HeJBir wild - type and
Il10 mice kept under special pathogen - free conditions and devoid of clinical and histopathological signs of
mucosal inflammation were monitored after
MNV infection for structural and functional intestinal barrier changes by in situ
MNV reverse transcription PCR , transgene reporter gene technology , histology , flux measurements , quantitative real - time PCR , immunohistology , and terminal deoxynucleotidyl transferase - mediated
dUTP nick end - labeling assay . -
pubmed
RESULTS : Although MNV - infected wild - type
mice remained asymptomatic ,
mucosal inflammation was noted in previously healthy
Il10 mice 2 to 4 weeks after
infection . -
pubmed
BACKGROUND :
Plerixafor is a Food and Drug Administration - approved agent for improving peripheral blood stem cell ( PBSC ) mobilization in filgrastim (
granulocyte - colony - stimulating factor [
G - CSF])-stimulated
patients with
multiple myeloma and
non - Hodgkin ' s lymphoma . -
pubmed
STUDY DESIGN AND METHODS : We retrospectively reviewed the collection data of 27 consecutive
HL patients at our center in whom
plerixafor was added to rescue a failing PBSC collection after
G - CSF and chemotherapy ( 26 ) or
G - CSF alone ( 1 ) . -
pubmed
A phase II study of
erlotinib monotherapy in pre - treated
non - small cell lung cancer without
EGFR gene mutation who have never / light smoking history : re - evaluation of
EGFR gene status ( NEJ006 / TCOG0903 ) . -
pubmed
OBJECTIVES :
Epidermal growth factor receptor (
EGFR )
tyrosine kinase inhibitors are particularly effective in
non - small cell lung cancer (
NSCLC ) patients harboring active
EGFR mutations . -
pubmed
However , some studies have reported survival benefits in
NSCLC patients with wild - type
EGFR upon
erlotinib treatment . -
pubmed
PATIENTS AND METHODS :
Patients with previously treated
NSCLC but without
EGFR gene mutations that had never or light smoked were eligible for this study . -
pubmed
Re - evaluations for
EGFR gene were performed in 32
tumor samples . -
pubmed
Six patients had
PR and two had
SD among these eight patients . -
pubmed
Patients with
tumors expressing
HGF showed shorter PFS but not MET or
TS . -
pubmed
In confirmed
EGFR wild
NSCLC , negative
HGF staining could be a biomarker for longer PFS by
erlotonib treatment . -
pubmed
Left ventricular diastolic dysfunction and
myocardial stiffness in
diabetic mice is attenuated by inhibition of
dipeptidyl peptidase 4 . -
pubmed
We investigated the effects of
sitagliptin (
SITA ) , an inhibitor of
dipeptidylpeptidase-4 (
DPP-4 ) and anti - diabetic drug , on LV structure and function of
obese mice with
Type 2 DM . -
pubmed
METHODS AND RESULTS :
Obese Type 2 diabetic mice ( Lepr(db / db ) , BKS.Cg -
Dock7(m)+/+ Lepr(db)/J ) , displaying increased cardiomyocyte and LV stiffness at the age of 16 weeks , were treated with
SITA ( 300 mg / kg / day ) or vehicle for 8 weeks . -
pubmed
CONCLUSIONS : In
obese Type 2 diabetic mice , in the absence of hypoglycaemic effects , inhibition of
DPP-4 decreases LV passive stiffness and improves global LV performance . -
pubmed
OBSERVATIONS : Whole - exome sequencing identified a novel , heterozygous p.(Gly671Trp ) mutation in the
AFG3L2 gene encoding an
mt protease -- previously associated with
dominant spinocerebellar ataxia type 28 disease -- in a
patient with
indolent ataxia and
PEO . -
pubmed
Targeted analysis of a larger , genetically undetermined cohort of patients with
PEO with suspected mtDNA maintenance abnormalities identified a second unrelated patient with a similar phenotype and a novel , heterozygous p.(Tyr689His )
AFG3L2 mutation . -
pubmed
CONCLUSIONS AND RELEVANCE : Our observations suggest that
AFG3L2 mutations are another important cause , albeit rare , of a late - onset
ataxic PEO phenotype due to a disturbance of mtDNA maintenance . -
pubmed
Abnormal nuclear expression of
Pygopus-2 in
human primary
hepatocellular carcinoma correlates with a poor prognosis . -
pubmed
The aim of the present study was to investigate the expression patterns and clinicopathological significance of
Pygo2 in
human primary
hepatocellular carcinoma (
HCC ) . -
pubmed
METHODS AND RESULTS : Real - time polymerase chain reaction ( PCR ) analysis of the mRNA levels of
Pygo2 in 50 paired
HCC cancer / adjacent
non - cancerous tissues showed that
Pygo2 mRNA expression was significantly higher in
cancerous tissues ( P = 0.009 ) . -
pubmed
Immunohistochemical analysis showed that abnormal
Pygo2 protein expression in
HCC patients was associated with age ( P = 0.025 ) ,
tumour size ( P = 0.005 ) , intra- or extra - hepatic metastasis ( P = 0.029 ) , vascular invasion ( P = 0.026 ) and
tumour differentiation ( P = 0.004 ) . -
pubmed
Cox 's proportional hazard regression model showed that abnormal
Pygo2 protein expression was a risk factor associated with the prognosis of
HCC patients ( P = 0.043 ) . -
pubmed
CONCLUSION : To the best of our knowledge , this is the first report investigating
Pygo2 expression patterns and their clinicopathological significance in
HCC . -
pubmed
Our findings suggest that
Pygo2 may be an important predictor of poor outcome in
HCC patients , and could serve as a novel biomarker for
HCC . -
pubmed
In addition , logistic binary regression analysis and linear regression analysis showed the miR-22 - 3p to be a protective factor for
POF ( odds ratio 0.766 , 95 % CI 0.643 - 0.912 ) and negatively associated with serum
FSH . -
pubmed
Plasma
IL-1Ra : linking hyperapoB to risk factors for
type 2 diabetes independent of
obesity in
humans . -
pubmed
BACKGROUND / OBJECTIVE : Plasma
apoB predicts the incidence of
type 2 diabetes (
T2D ) ; however , the link between
apoB - linpoproteins and risks for
T2D remain unclear . -
pubmed
Insulin resistance ( IR ) and compensatory
hyperinsulinemia characterize
prediabetes , and the involvement of an activated
interleukin-1 ( IL-1 ) family , mainly
IL-1beta and its receptor antagonist (
IL - Ra ) , is well documented . -
pubmed
We hypothesized that
obese subjects with
hyperapoB have an activated
IL-1 system that explains
hyperinsulinemia and
IR in these subjects . -
pubmed
Plasma
apoB ( 0.34 - 1.80 g l(-1 ) ) associated significantly with
hypersinsulinemia (
totalIVGTT : C - peptide r=0.27 ,
insulin r=0.22 ) , IR ( M / I=-0.29 ) and plasma
IL-1Ra ( r=0.26 ) but not with
IL-1beta . -
pubmed
Plasma
IL-1Ra associated with plasma
IL-1beta ( r=0.40 ) , and more strongly with
hyperinsulinemia and IR than
apoB , while the association of plasma
IL-1beta was limited to second phase and total
insulin secretion ( r=0.23 ) . -
pubmed
Adjusting the association of plasma
apoB to
hyperinsulinemia and IR for
IL-1Ra eliminated these associations . -
pubmed
CONCLUSION : Plasma
apoB is associated with
hyperinsulinemia and IR in normoglycemic obese
subjects , which is eliminated upon adjustment for plasma
IL-1Ra . -
pubmed
This may implicate the
IL-1 family in elevated risks for
T2D in
obese subjects with
hyperapoB. -
pubmed
Evaluation of Abbott Architect high - sensitivity
troponin I assay for
haemolysis interference . -
pubmed
RESULTS : PCR results indicated that 90.6 % ( 48/53 ) , 82 % ( 50/61 ) and 73.6 % ( 39/53 ) strains from
DU patients were positive for
cagA ,
vacA , and
babA2 , respectively . -
pubmed
After the final behavioral testing , L3 - L5 spinal cord tissues were removed to exam the expression of microglia marker
OX42 by Western blotting and immunofluorescence technique , and the changes in the expression of
inflammation factor
IL-1beta ,
IL-6 ,
TNF - alpha were detected by ELISA technique . -
pubmed
The ratio of spinal microglia marker
OX42 and
GAPDH , the expression of
inflammation factor
IL-1beta ,
IL-6 , and
TNF - alpha in group N were 0.074 + -0.023 , ( 35.93 + -6.16 ) pg / ml , ( 92.11 + -13.23 ) pg / ml , and ( 169.50 + -22.64 ) pg / ml , respectively . -
pubmed
The ratio of spinal microglia marker
OX42 and
GAPDH , the expression of
inflammation factor
IL-1beta ,
IL-6 , and
TNF - alpha in group DNP were 1.023 + -0.185 , ( 73.82 + -9.25 ) pg / ml , ( 155.33 + -21.82 ) pg / ml , and ( 298.30 + -33.21 ) pg / ml , respectively . -
pubmed
The ratio of spinal microglia marker
OX42 and
GAPDH , the expression of
inflammation factor
IL-1beta ,
IL-6 , and
TNF - alpha in group Sham were 0.951 + -0.103 , ( 73.00 + -7.54 ) pg / ml , ( 151.02 + -24.26 ) pg / ml , and ( 294.01 + -36.37 ) pg / ml , respectively . -
pubmed
Compared with group N , the expression of spinal microglia marker
OX42 and
inflammation factor
IL-1beta ,
IL-6 , and
TNF - alpha in group DNP , group Sham and group R increased significantly ( F=7.501 , 348.698 , 568.021 , 145.110 , all P<0.05 ) . -
pubmed
Compared with DNP group , the expression of spinal microglia marker
OX42 and
inflammation factor
IL-1beta ,
IL-6 , and
TNF - alpha of group R reduced significantly ( all P<0.05 ) . -
pubmed
Therefore , this review focuses on the role that the interaction between
vitamin D ,
VDR function , and gut microbiome might have on
autoimmune diseases in the context of the hygiene hypothesis . -
pubmed
The biologically active form of
vitamin D ,
1,25 ( OH ) 2D3 , serves as the primary ligand for
VDRs , which have been shown to play a fundamental role in reducing
autoimmune disease symptoms . -
pubmed
Although the biological functions of
VDR , the effects of its genetic variants , and the effects of epigenetic profiles in its promoter region are largely unknown in
humans , studies in
murine models are increasingly demonstrating that
VDRs play a crucial role in attenuating
autoimmune disease symptoms by regulating autophagy and the production of antimicrobial peptides , such cathelicidin and
beta - defensin , which are responsible for modifying the intestinal microbiota to a healthier composition . -
pubmed
Therefore , understanding the interaction between
VDR and gut microbiota is of the utmost importance toward understanding the rise in
autoimmune diseases in Western countries . -
pubmed
We have gained insights on how the
VDR functions affects
inflammation , autophagy , and microbiota composition that could lead to the development of pathogenesis of
autoimmune diseases , while confirming the role
vitamin D and
VDRs have in the context of hygiene hypothesis . -
pubmed
Polymorphisms and features of
cytomegalovirus UL144 and
UL146 in congenitally infected neonates with
hepatic involvement . -
pubmed
In this study , we investigated the polymorphisms and features of the viral genes
UL144 and
UL146 as well as their significance to
congenital hepatic involvement . -
pubmed
In 79 neonates with
congenital cytomegalovirus infection and hepatic involvement , full length
UL144 and
UL146 were successfully amplified in 73.42 % and 60.76 % of cases , respectively . -
pubmed
In conclusion , dominant
UL144 ( genotype B ) and
UL146 ( genotype G1 and G13 ) genotypes are associated with elevated levels of enzymes and
CMV IgM and
IgG of
cytomegalovirus infection . -
pubmed
A mutation ( p. A211V ) in the gene that encodes
VGLUT3 is responsible for progressive
deafness in two unrelated families . -
pubmed
A point mutation of
VGLUT3 (
VGLUT3 - p. A211V ) responsible for a progressive
loss of hearing has been identified in
humans . -
pubmed
Expression of
P301L - hTau in
mouse MEC induces hippocampus - dependent
memory deficit . -
pubmed
Intracellular accumulation of abnormally phosphorylated
tau in different types of neurons is a pathological characteristic of
Alzheimer ' s disease (
AD ) . -
pubmed
While tau modification and associated
neuronal loss and hypometabolism start in the entorhinal cortex ( EC ) in early
AD patients , the mechanism by which mutant P301L
hTau leads to
dementia is not fully elucidated . -
pubmed
Here , we studied the effects of P301L hTau transduction in the medial EC ( MEC ) of
mice on
tau phosphorylation and accumulation , and
cognitive deficit . -
pubmed
Interestingly , expression of the mutant
tau in MEC induces endogenous tau hyperphosphorylation and accumulation in hippocampus and cortex , and inhibits neuronal activity with attenuated PP - DG synapse plasticity , leading to hippocampus - dependent
memory deficit with intact olfactory function . -
pubmed
These findings suggest a novel neuropathological mechanism of early
AD , which is initiated by
tau accumulation in MEC , and demonstrate a
tau pathological model of early stage
AD . -
pubmed
Fluctuation of diffusion - weighted imaging and apparent diffusion coefficient in
acute stroke following
tissue plasminogen activator administration . -
pubmed
Role of
triosephosphate isomerase and downstream functional genes on
gastric cancer . -
pubmed
Triosephosphate isomerase (
TPI ) is highly expressed in many types of
human tumors and is involved in migration and invasion of
cancer cells . -
pubmed
However ,
TPI clinicopathological significance and malignant function in
gastric cancer (
GC ) have not been well defined . -
pubmed
The present study aimed to examine
TPI expression in
GC tissue and its biological functions . -
pubmed
Our results showed that
TPI expression was higher in
gastric cancer tissues than adjacent tissues , although no statistical differences were found between
TPI expression and clinicopathological factors . -
pubmed
TPI overexpression in
human gastric carcinoma cell line
BGC-823 enhanced cell proliferation , invasion and migration , but did not change cell cycle distribution , while
TPI knockdown suppressed proliferation , invasion and migration , induced apoptosis and increased G2 / M arrest of
human gastric carcinoma cell line
MGC-803 . -
pubmed
These results indicated that
TPI expression level might affect GC cell behavior , suggesting that both
TPI and
CDCA5 might be considered as potential
tumor markers related with
GC development and might be potential new targets in GC treatment . -
pubmed
Objectives The association of
anti - tumor necrosis factor therapy with
opportunistic infections in
rheumatoid arthritis (
RA ) patients has been reported . -
pubmed
PURPOSE : The upregulation of
vascular cell adhesion molecule-1(
VCAM-1 ) on vascular endothelium plays a great role in the progression of
atherosclerosis (
AS ) . -
pubmed
In this study , ultrasound molecular imaging was performed to monitor the
inflammation injuries in the onset and progression of
atherosclerosis with microbubbles targeted to
VCAM-1 . -
pubmed
METHODS :
Mice deficient for the
apolipoprotein E (
ApoE-/-
mice ) with high -
cholesterol diet were studied as an age - dependent model of
atherosclerosis . -
pubmed
Moreover , signals from targeted microbubbles increased from 8wks to 32wks age ( P<0.05 for trend ) in
ApoE-/-
mice , indicating the upregulation of
VCAM-1 with the progression of
atherosclerosis . -
pubmed
CONCLUSIONS : CEU molecular imaging can be used to noninvasively detect the
VCAM-1 expression on the endothelium in the progression of
atherosclerosis . -
pubmed
Single - molecule DNA sequencing of
acute myeloid leukemia and
myelodysplastic syndromes with multiple
TP53 alterations . -
pubmed
Prostate cancer (
PCa ) is a leading cause of
cancer - related deaths in men and the
TMPRSS2 -
ERG gene fusion is a recurrent biomarker in about 50 % of all
prostate cancers . -
pubmed
However , current screening tools for
TMPRSS2 - ERG are generally confined to research settings and hence , the development of a rapid , sensitive and accurate assay for
TMPRSS2 -
ERG detection may aid in clinical
PCa diagnosis and treatment . -
pubmed
Our assay can specifically detect as low as 103 copies input of
TMPRSS2 -
ERG transcripts and was successfully applied to clinical
PCa urinary samples . -
pubmed
Hence , we believe our assay is a potential clinical screening tool for
TMPRSS2 -
ERG in
PCa and may have broad applications in detecting other gene fusion transcripts in other diseases . -
pubmed
We evaluated the changes in
endometriosis - associated
pain scores ( visual analog scale [ VAS ] ) ,
serum cancer antigen 125 (
CA-125 ) levels , and
endometrioma sizes following DNG medication in these
women along with adverse events associated with DNG medication . -
pubmed
Moreover , the size of recurrent
endometriomas and
CA-125 levels also decreased significantly compared to baseline . -
pubmed
Here , we aim to study whether leukocyte telomere length ( LTL ) may independently predict
albuminuria progression in
patients with
T2D with preserved renal filtration function ( estimated GFR & gt;60 ml / min per 1.73 m2 and
urine albumin - to -
creatinine ratio [ uACR ] & lt;300 mg / g ) . -
pubmed
Several
lymphoma treatments have reported anti - pruritic effects including
romidepsin , a potent class 1 selective
histone deacetylase inhibitor approved for the treatment of
patients with
CTCL who have had at least one prior systemic therapy . -
pubmed
R406 elicits anti - Warburg effect via
Syk - dependent and -independent mechanisms to trigger apoptosis in
glioma stem cells . -
pubmed
Utilizing an anti - cancer compound library , we identified
R406 , the active metabolite of a FDA - approved
Syk inhibitor for
immune thrombocytopenia (
ITP ) , with remarkable
cytotoxicity against GSCs but not normal neural stem cells . -
pubmed
Co - localizations of fRPE e / sQTLs with age - related
macular degeneration (
AMD ) and
myopia GWAS data suggest new candidate genes , and mechanisms by which a common
RDH5 allele contributes to both increased
AMD risk and decreased
myopia risk . -
pubmed
Previous studies have regarded the discriminatory serum
beta - hCG zone ( DSZ ) as a valuable tool for the diagnosis of
ectopic pregnancy (
EP ) . -
pubmed
We enrolled participants with
IUPs or EPs with
abdominal pain and/or
vaginal bleeding , and serum
beta - hCG level measurements and transvaginal ultrasound ( TVS ) were performed to assess the diagnostic value of the indicators for
EP . -
pubmed
Association of TILs with clinical parameters , Recurrence Score results , and prognosis in
patients with early
HER2 - negative
breast cancer (
BC)-a translational analysis of the prospective WSG PlanB trial . -
pubmed
METHODS : The WSG PlanB trial compared an
anthracycline - free chemotherapy regimen ( 6x
docetaxel /
cyclophosphamide , TC ) to an
anthracycline -
taxane sequence ( 4xEC followed by 4x
docetaxel ) in
patients with intermediate - risk ,
HER2 - negative early
breast cancer (
EBC ) . -
pubmed
CONCLUSION : Although the presence of high TILs is associated with negative prognostic parameters such as high
KI67 and
HR - negative status among patients with
HR - positive HER2 - negative EBC , patients with high TILs show a favorable 5 - year DFS in both
HR - positive / HER2 - negative and triple - negative
breast cancer . -
pubmed
Activities of
sulphatases A / B ,
sulphatase C ,
beta glucuronidase , acid and
alkaline phosphatase were measured in 38 cases of
colorectal cancer . -
pubmed
We investigated the distribution and expression of mutant mtDNAs carrying the A - to - G mutation at position 8344 in the
tRNA ( Lys ) gene in the skeletal muscle of four
patients with
myoclonus epilepsy and
ragged - red fibers (
MERRF ) . -
pubmed
The application of F - SSCP for detection of mutations and loss of heterozygosities of
p53 in
tumor tissues is reported . -
pubmed
The
children in P1 and P2A classes demonstrated an increase in
CD8 + cells ; only the children with
AIDS showed a significant decrease in
CD4 + cells . -
pubmed
[ Effects of the
PAF antagonist
WEB 2086 on
hypoxia and
angiotensin II - induced pulmonary vasoconstriction in the isolated perfused
rat lung ] . -
pubmed
Using isolated blood - perfused lung preparations of
rats , we tested the influence of the
PAF antagonist
WEB 2086 on vasoconstriction triggered by
hypoxia or
angiotensin II (
A II ) . -
pubmed
Effect of exercise training on
insulin sensitivity and
glucose metabolism in lean ,
obese , and
diabetic men . -
pubmed
To clarify the impact of vigorous physical training on in vivo
insulin action and
glucose metabolism independent of the intervening effects of concomitant changes in body weight and composition and residual effects of an acute exercise session , 10 lean , 10
obese , and 6 diet - controlled
type II diabetic men trained for 12 wk on a cycle ergometer 4 h / wk at approximately 70 % of maximal
O2 uptake ( VO2max ) while body composition and weight were maintained by refeeding the energy expended in each training session . -
pubmed
Insulin sensitivity was not significantly altered by training in any group , but basal hepatic
glucose production was reduced by 22 % in the
diabetic men . -
pubmed
Thus , when intervening effects of the last exercise bout or body composition changes were controlled , exercise training per se leading to increased cardiorespiratory fitness had no independent impact on
insulin action and did not improve the
insulin resistance in
obese or
diabetic men . -
pubmed
Increased production of
interleukin-1 (
IL-1 ) occurs following
hemorrhage and
thermal injury . -
pubmed
Hemorrhage , accidental
trauma and
burns are followed by decreased
interleukin-2 (
IL-2 ) generation . -
pubmed
Production of
interleukin-3 (
IL-3 ) and
interleukin-5 (
IL-5 ) is diminished following
hemorrhage . -
pubmed
Gamma - interferon release appears to be increased following
hemorrhage . -
pubmed
Stress secondary to
infection is accompanied by marked elevations in serum levels of
tumor necrosis factor (
TNF ) , which contribute to
hypotension and physiologic instability in this setting . -
pubmed
Increased generation of
IL-1 , and probably of
TNF and
IL-6 , contributes to the acute - phase reaction and hypermetabolic response which accompanies injury ,
burns ,
hemorrhage , and overwhelming
infection . -
pubmed
Severe immunosuppression , involving both T and B cell function , and contributing to the increased incidence of
infection after injury may result , at least in part , from the multiple actions of stress - induced alterations in
interleukin release . -
pubmed
Subclasses of
IgG H chain expressed in the
rheumatoid synovium . -
pubmed
We conclude that some patients of
rheumatoid arthritis exhibit an increased level of a unique
IgG subclass . -
pubmed
We could demonstrate a high functional activity of fibroblasts with secretion of mucopolysaccharides and
type III collagen around
intraductal carcinomas . -
pubmed
This paper reports on the diagnostic usefulness of two commercial
PTH assay kits and four " in - house " assays using commercially available reagents , studying the same samples from
normal controls and different patient groups . -
pubmed
Patients with
PTH secondary to
chronic renal disease were well discriminated from normal by all assays . -
pubmed
Although immunoassays are useful in many cases of 1 degree
HPT , it is difficult to develop C - terminal or mid - region
PTH assays that are uniformly diagnostically useful in the clinical situation where they are of greatest potential use i.e. -
pubmed
[
Neutrophil elastase and the lung , with special reference to the pathogenesis of
ARDS ] . -
pubmed
Cultured
human cells derived from pancreatic , gastric , duodenal , and
gall bladder cancers secreted a considerable amount of
pancreatic secretory trypsin inhibitor into the culture medium . -
pubmed
Platelet associated complement components (
PAC3c and
PAC3d ) in
patients with
autoimmune thrombocytopenia . -
pubmed
Platelet associated
C3c and
C3d (
PAC3c and
PAC3d ) were quantitated by enzyme linked assay in 105
patients with
idiopathic autoimmune thrombocytopenia (
AITP ) in whom elevated
platelet associated immunoglobulins (
IgG and
IgM ) had previously been documented . -
pubmed
The
immunological disorders in
patients with intestinal
lymphangiectasia appear to result from loss of
immunoglobulins and lymphocytes into the gastrointestinal tract secondary to
disorders of lymphatic channels . -
pubmed
Influence of
naloxone on
prolactin secretion in
patients with acute and
chronic renal failure . -
pubmed
The influence of the opiate antagonist
naloxone on
chlorpromazine induced
prolactin secretion was examined in 12
patients with
acute renal failure (
ARF ) , 12
patients with
chronic renal failure (
CRF ) and in 12 healthy
subjects . -
pubmed
In all examined groups
naloxone showed a suppressive effect on
chlorpromazine induced
prolactin secretion , which was more accentuated in
normals and
patients with
ARF then with
CRF . -
pubmed
The results of these investigations suggest that endogenous opiates may be of importance in the regulation of
prolactin secretion both in normals and
uremic patients . -
pubmed
Pathophysiology of
gastrointestinal trichostrongyles in
sheep : plasma losses and changes in
plasma pepsinogen levels associated with parasite challenge of immune animals . -
pubmed
The incorporation of
tritiated thymidine was significantly greater for lymphocytes from
mice infected with the pathogenic Indonesian strain than for lymphocytes from
mice infected with the non - pathogenic Formosan strain in response to
SAA ; the responses also increased with duration of
infection . -
pubmed
Sensitivity and specificity of laboratory criteria , including
CA 125 , compared unfavorably with others and are of no use in early diagnosis of
ovarian malignancies . -
pubmed
Proliferative responses of peripheral blood mononuclear cells from
patients with
Graves ' disease to synthetic peptides epitopes of
human thyrotropin receptor . -
pubmed
In
Graves ' disease thyrotropin receptor (
TSH - R ) autoantibodies cause
hyperthyroidism . -
pubmed
These results suggest that ( a ) TSH - R - specific T cells are present in peripheral blood of
patients with
Graves ' disease , and ( b ) sequence segments 152 - 157 and 207 - 222 may be
T cell epitopes of the
human TSH - R in
Graves ' disease . -
pubmed
Generation of active
oxygen forms ( GAOF ) by alveolar macrophages ( AM ) and leukocytes , the role of
GAOF in provoking a
bronchial asthma ( BA ) attack were studied simultaneously and compared in 10
asthmatics , 10 chronics with
bronchitis and 5 healthy subjects . -
pubmed
Both healthy subjects and the
patients had
GAOF by leukocytes more active than GAOF by AM , their proportion being less in
asthmatics . -
pubmed
This study noninvasively measured
hemoglobin oxygen saturation in young ( n = 6 , 28 + /- 6 yrs ) , old healthy ( n = 20 , 68 + /- 7 yrs ) , and old subjects with mild
peripheral vascular disease (
PVD ) ( n = 8 , 72 + /- 4 yrs ) . -
pubmed
This neutralizing activity was absent in the
IgG fractions prepared from sera of healthy volunteers , noninfected
mice or
mice killed at different times during
acute T. cruzi infection . -
pubmed
The presence of
TIF - neutralizing antibodies during chronic but not
acute T. cruzi infection may be one of the reasons why immunosuppression is confined to the acute stage . -
pubmed
Many of the regulatory effects are mediated through the release of
cytokines , a group of hormones that also promotes
inflammation and replenishes hematopoietic elements . -
pubmed
The various lymphocyte types within the adaptive immune system are interdependent , as evidenced by the
X - linked hyper - IgM syndrome in which a
T - cell deficiency (
CD40 ligand ) manifests clinically as an antibody production problem . -
pubmed
We report a 6 - month longitudinal follow - up of biochemical markers of bone metabolism ( free and total
deoxypyridinoline , total
pyridinoline , N - telopeptide ,
osteocalcin , and
total alkaline phosphatase ) and bone mineral densitometry in 30
subjects with
acute SCI . -
pubmed
Our results suggest that different sorting mechanisms for
P - selectin are used in platelets and endothelial cells and that the storage pool of
P - selectin in endothelial cells is functionally important during early stages of
inflammation . -
pubmed
Enhanced expression of
interleukin-6 in
chronic hepatitis C. -
pubmed
AIMS / BACKGROUND : There is a possibility that proinflammatory
cytokines such as
interleukin-6 (
IL-6 ) are involved in the inflammatory process of
chronic hepatitis C. -
pubmed
This study was undertaken to investigate the possible role of
IL-6 in the pathophysiology of
chronic hepatitis C. -
pubmed
METHODS : Serum
IL-6 levels in 63
patients with
chronic hepatitis C and in 26 normal controls were measured . -
pubmed
RESULTS : Serum
IL-6 levels were significantly ( p<0.01 ) elevated in
chronic hepatitis C compared to those in normal controls . -
pubmed
Pseudo - metabolic presentation in a
Duchenne muscular dystrophy symptomatic carrier with ' de novo ' duplication of
dystrophin gene . -
pubmed
Upon immunofluorescence , a mosaic pattern of
dystrophin deficiency was found , and in the
dystrophin deficient muscle fibres , the four proteins of the sarcoglycan complex were also lacking . -
pubmed
Inducible
nitric oxide synthase (
iNOS ) was shown to be expressed in
normal mucosa and
adenoma of small and large intestines of
Apc ( Min /+ ) mice by reverse transcription - PCR and immunohistochemistry . -
pubmed
Administration of the
iNOS inhibitor
aminoguanidine ( 1.5 g / liter ) in drinking water or an
L - arginine - deficient diet to
Apc ( Min /+ ) mice resulted in a significant decrease in
adenoma development in the small but not the large intestine . -
pubmed
Similarly ,
iNOS - gene knockout
Apc ( Min /+ ) mice (
Apc ( Min /+ ) iNOS(-/- ) or
Apc(Min/+ )
iNOS(-/+ ) ) developed significantly fewer
adenomas in both small and large intestines than
Apc ( Min /+ ) iNOS (+/+ ) mice . -
pubmed
These results suggest that
iNOS - selective inhibitors could be used as a potential chemopreventive agent for
colorectal cancers . -
pubmed
SYT -
SSX is critical for
cyclin D1 expression in
synovial sarcoma cells : a gain of function of the t(X;18)(p11.2;q11.2 ) translocation . -
pubmed
The
SYT -
SSX fusion gene has been implicated in the
malignant tumor cell growth of
synovial sarcoma , but the underlying molecular mechanisms are still poorly understood . -
pubmed
Here we demonstrate that
SYT -
SSX is critical for the protein level of
cyclin D1 in
synovial sarcoma cells . -
pubmed
Taken together , our study provides evidence that
SYT -
SSX stabilizes
cyclin D1 and is critical for
cyclin D1 expression in
synovial sarcoma cells . -
pubmed
SYT -
SSX - dependent expression of
cyclin D1 may be an important mechanism in the development and progression of
synovial sarcoma and also raises the possibility for targeted therapy . -
pubmed
More importantly ,
Gp96 provides the first example of how the innate and adaptive immune system can be stimulated simultaneously by the same molecule which is released under physiological conditions from
necrotic cells . -
pubmed
Here , we demonstrate that the obligate intracellular parasite ,
Toxoplasma gondii , down - regulates activation - induced
MHC class II expression in
human - derived
glioblastoma cells as well as in primary astrocytes and microglia from cortices of
rat fetuses . -
pubmed
MHC class II transcript levels induced by
IFN - gamma alone or in combination with
TNF - alpha were also clearly diminished after
parasitic infection . -
pubmed
[ Expression of
urokinase - type plasminogen activator and its receptor protein in synovial tissues from
osteoarthritis ] . -
pubmed
OBJECTIVE : To study the expression of
urokinase - type plasminogen activator (
uPA ) and its receptor (
uPAR ) in the synovial tissures , and the significance of
uPA and
uPAR in degradation of extracellular matrices in
osteoarthritis (
OA ) , then analyse the possible relationship between
uPA and
uPAR . -
pubmed
METHODS : Immunohistochemical analysis technique was used to detect
uPA and
uPAR protein expression and distribution in synovial tissues in 26
OA patients and 10 mormal
individuals . -
pubmed
RESULTS : Positive staining of
uPA and
uPAR protein were detected in 19 cases in the 26
OA samples ( 73 % ) , while only 2 positive cases were seen in the 10 mormal tissues ( 20 % ) . -
pubmed
The expression rate of
uPA protein was markedly higher in
OA than in the normal ( P & lt ; 0.01 ) . -
pubmed
The expression of
uPAR was seen in 14 cases in all 26
OA samples ( 54.6 % ) , while there was only one case in 10 normal samples ( 10 % ) , the positive rate was significantly higher in
OA than in normal samples ( P & lt ; 0.05 ) . -
pubmed
Using the correction analysis , we found a positive correlation between
uPA and
uPAR reactivity in the synovial tissues in
OA ( r = 0.920 , P & lt ; 0.01 ) . -
pubmed
CONCLUSIONS : The high expression of
uPA and
uPAR protein in
OA synovial tissues indicate that the
uPA system may play an important role in the process of
synovitis and degradation of
OA cartilage extracellular matrices . -
pubmed
In the pathologic process of
OA ,
uPA and
uPAR coordinate each other , lead to the genesis and development of
OA cartilage degradation . -
pubmed
In addition , a variety of genetic risk factors , such as
factor V Leiden ,
protein S or C deficiency have also been identified . -
pubmed
Notch and
cancer : best to avoid the ups and downs . -
pubmed
Two recent studies add to our understanding of
Notch in
cancer biology in contrasting ways , by showing novel mechanisms of Notch pathway activation in
cancer cells , and by indicating that in some circumstances ,
Notch can behave as a
tumor suppressor . -
pubmed
[ Mechanism of the hypothermic action of
insulin :
hypoglycemia and disequilibrium of the plasma ions ] . -
pubmed
We examined the potential possibility of an interaction between
nicotine , a major component of cigarette smoke , and
angiotensin II (
Ang II ) , which plays an important role in the pathogenesis of
cardiovascular diseases characterized by
Ang II type 1 ( AT1 ) receptor - mediated abnormal growth of vascular smooth muscle cells ( VSMC ) and fibroblasts . -
pubmed
Increased expression of the
epidermal growth factor ( EGF ) receptor (
EGFR ) and
ErbB-2 is implicated into the development and progression of
breast cancer . -
pubmed
Mammary
tumor cells that express low levels of both receptors or high levels of
ErbB-2 and low levels of
EGFR survive and proliferate in the presence of
EGF . -
pubmed
In contrast , fibroblastic cells or
mammary tumor cells , which co - express high levels of
EGFR and
ErbB-2 invariably undergo apoptosis in response to
EGF . -
pubmed
Fibroblast growth factor receptor expression in
aural polyps : predictor of
cholesteatoma ? -
pubmed
The
cytokine ,
fibroblast growth factor (
FGF ) and its receptors (
FGFR ) have a pivotal role in
wound repair and have been demonstrated in the perimatrix of active
cholesteatoma . -
pubmed
This study examines 28 archival aural
polyp specimens , seeking an increased expression for
FGFR1 and
FGFR3 in
polyps associated with
cholesteatoma , when compared with those arising in
non - cholesteatomatous , mucosal disease , but produced a null result . -
pubmed
Rana catesbeiana ribonuclease (
RC - RNase ) possesses tumor - specific
cytotoxicity , which can be synergized by
IFN - gamma . -
pubmed
Our findings provide evidence that
RC - RNase and
RC - RNase /
IFN - gamma can kill different
cancer cells by distinct mechanisms . -
pubmed
Biochemical markers of
prostate cancer risk such as
prostate - specific antigen (
PSA ) and
insulin - like growth factors (
IGFs ) were measured on plasma samples collected at enrollment and at the end of follow - up from 3,616 men . -
pubmed
Among men with normal
PSA , there was a marked statistically significant reduction in the rate of
prostate cancer for men receiving the supplements ( hazard ratio = 0.52 ; 95 % CI = 0.29 - 0.92 ) . -
pubmed
In men with elevated
PSA at baseline , the supplementation was associated with an increased incidence of
prostate cancer of borderline statistical significance ( hazard ratio = 1.54 ; 95 % CI = 0.87 - 2.72 ) . -
pubmed
These results suggest that previously described
hypotensive action of the beverage may be partly induced by the inhibition of
angiotensin - converting enzyme . -
pubmed
Rare missense variants in
ATP1A2 in families with clustering of common forms of
migraine . -
pubmed
Familial hemiplegic migraine (
FHM ) is a rare monogenic subform caused by mutations in the
calcium channel gene
CACNA1A or the
Na (+)/ K (+)- ATPase gene
ATP1A2 . -
pubmed
An involvement of
FHM genes in the pathogenesis of common forms of
migraine is not proven . -
pubmed
We therefore systematically screened
ATP1A2 in families with several members affected by
MA and/or
MO . -
pubmed
In conclusion we propose that rare variants in
ATP1A2 are involved in the susceptibility to common forms of
migraine , because of 1 ) the absence of alterations in controls , 2 ) the particular pattern of segregation in both families , 3 ) the high conservation of mutated residues in
Na (+)/ K (+)- ATPases , 4 ) the functional effect of C515Y , and 5 ) the involvement of
ATP1A2 in a monogenic form of
migraine . -
pubmed
Anti -
CD20 monoclonal antibody ( rituximab ) in the treatment of
pemphigus . -
pubmed
BACKGROUND :
Pemphigus is a severe
autoimmune blistering disorder caused by autoantibodies to
desmoglein 1 and 3 . -
pubmed
Bone mineral density and
cytokine levels during
interferon therapy in
children with
chronic hepatitis B : does
interferon therapy prevent from
osteoporosis ? -
pubmed
BACKGROUND : Our aim was to determinate bone mineral density ( BMD ) , levels of biochemical markers and
cytokines in
children with
chronic hepatitis B treated with
interferon ( IFN )- alpha and to investigate effect of
IFN - alpha therapy on these variables . -
pubmed
To the best of our knowledge , this is first study carried out about BMD and
cytokine levels in pediatric
patients with
chronic hepatitis B treated with
IFN - alpha . -
pubmed
METHODS : BMD , levels of
parathyroid hormone (
PTH ) ,
osteocalcin , C - terminal cross - linking telopeptide of
type I collagen (
CTX ) ,
calcium ,
alkaline phosphates ( ALP ) ,
cytokines as
TNF - alpha ,
interleukin ( IL )- 1beta ,
IL-2r ,
IL-6 , and
IL-8 were studied in 54
children with
chronic hepatitis B ( 4 - 15 years old ) treated with
interferon alone ( n = 19 ) or in combination with
lamivudine ( n = 35 ) for six months and as controls in 50 age - matched healthy
children . -
pubmed
RESULTS : There was no significant difference in respect to serum
IL-1beta ,
TNF - alpha and
osteocalcin levels while serum
IL-2r ( p = 0.002 ) ,
IL-6 ( p = 0.001 ) ,
IL-8 ( p = 0.013 ) ,
PTH ( p = 0.029 ) , and
CTX ( p = 0.021 ) levels were higher in
children with
chronic hepatitis B than in healthy controls . -
pubmed
CONCLUSION : In conclusion , our study suggest that BMD of femur , serum
IL-2r ,
IL-6 ,
IL-8 ,
PTH , and
CTX levels were higher in
children with
chronic hepatitis B treated with
IFN - alpha alone or combination with
lamivudine than in healthy
children . -
pubmed
High femur BMD measurements found in
patients may suggest that
IFN - alpha therapy in
children with
chronic hepatitis B could contribute indirectly to prevent from
hip osteoporosis . -
pubmed
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating
p53 - dependent cellular senescence . -
pubmed
Dysfunctional telomeres induce
p53 - dependent cellular senescence and apoptosis , but it is not known which function is more important for
tumour suppression in vivo . -
pubmed
Tumour suppression is accompanied by global induction of
p53 ,
p21 and the senescence marker senescence - associated - beta - galactosidase . -
pubmed
CONCLUSIONS :
Granulocyte colony - stimulating factor (
G - CSF ) ,
all - trans retinoic acid (
ATRA ) , and vaccines met 2 of 3 criteria for an association with
SS . -
pubmed
The mechanism of
CD4(+ ) T - cell depletion in
human immunodeficiency virus type 1 ( HIV-1 )- infected individuals remains unknown , although mounting evidence suggests that direct viral cytopathicity contributes to this loss . -
pubmed
Enhanced invasive and metastatic potential induced by
transforming growth factor - beta1 might be correlated with
glutathione - S - transferase - pi ,
cofilin and
heat shock protein 27 in
SGC-7901 gastric cancer cells . -
pubmed
In our previous study , we found that the
transforming growth factor ( TGF )- beta1 enhanced the metastatic and invasive potential of
gastric cancer cells . -
pubmed
CONCLUSIONS : The combination of QD or BID treatment with
MER+S was significantly more effective in lowering
HbA ( 1c ) and
glucose levels than
sulfonylurea monotherapy in these adult
patients with
type 2 diabetes . -
pubmed
On the other hand , chronic and dysregulated activation of some inducible enzymes , including
NADPH oxidase (
NOX ) ,
inducible nitric oxide synthase (
iNOS ) and
cyclooxygenase ( COX )- 2 , have been shown to play pivotal roles in the development of certain
inflammatory diseases such as oncogenesis . -
pubmed
Herein , the
cancer preventive potentials of several food phytochemicals targeting the induction of
NOX ,
iNOS and
COX-2 are described . -
pubmed
Stimulation of
TLR2 and
TLR4 differentially skews the balance of T cells in a
mouse model of
arthritis . -
pubmed
TLRs may contribute to the progression of
rheumatoid arthritis through recognition of microbial or host - derived ligands found in arthritic joints . -
pubmed
Here , we show that
TLR2 and
TLR4 , but not
TLR9 , are involved in the pathogenesis of
autoimmune arthritis and play distinct roles in the regulation of T cells and
cytokines . -
pubmed
We investigated the involvement of
TLR2 ,
TLR4 , and
TLR9 in the progression of
arthritis using
IL-1 receptor antagonist - knockout (
IL1rn -/- ) mice , which spontaneously develop an
autoimmune T cell - mediated arthritis . -
pubmed
Spontaneous onset of
arthritis was dependent on
TLR activation by microbial flora , as germ - free
mice did not develop
arthritis . -
pubmed
Clinical and histopathological evaluation of
IL1rn-/-
Tlr2-/-
mice revealed more severe
arthritis , characterized by reduced suppressive function of Tregs and substantially increased
IFN - gamma production by T cells . -
pubmed
IL1rn-/-
Tlr4-/-
mice were , in contrast , protected against severe
arthritis and had markedly lower numbers of Th17 cells and a reduced capacity to produce
IL-17 . -
pubmed
A lack of
Tlr9 did not affect the progression of
arthritis . -
pubmed
While any therapeutic intervention targeting
TLR2 still seems complicated , the strict position of
TLR4 upstream of a number of pathogenic
cytokines including
IL-17 provides an interesting potential therapeutic target for
rheumatoid arthritis . -
pubmed
BACKGROUND : This is a report of a
patient with a novel genotype - phenotype relationship of a c804 mutation of the
RET proto - oncogene manifesting as
medullary thyroid carcinoma (
MTC ) and
cutaneous lichen amyloidosis (
CLA ) . -
pubmed
Role of two nutritional hepatic markers (
insulin - like growth factor 1 and
transthyretin ) in the clinical assessment and follow - up of acute intermittent
porphyria patients . -
pubmed
RESULTS : Most of the serum proteins were within normal limits , however
insulin - like growth factor 1 (
IGF-1 ) was decreased in 53.8 % of
AIP patients ( z - score = -2.86 + /- 0.37 ) and
transthyretin (
prealbumin ) was found significantly decreased in 38.5 % of them . -
pubmed
We propose the use of both
IGF-1 and
transthyretin as biomarkers of disease morbidity / severity for the clinical follow - up of
AIP patients . -
pubmed
The effect of
GH replacement after 2 years was assessed in those with available follow - up data ( 133
IGHD , 2207 MPHD ) , and development of new deficiencies in those with available data on concomitant medication ( 165 IGHD , 3006 MPHD ) . -
pubmed
RESULTS :
IGHD and
MPHD patients had similar baseline clinical presentation , and both groups responded similarly to 2 years of
GH therapy , with favourable changes in lipid profile and improved quality of life . -
pubmed
CONCLUSION : Both
AO - IGHD and -MPHD
patients have similar baseline clinical presentation and respond equally well to 2 years of
GH replacement . -
pubmed
Expression of
p53 ,
c - erbB-2 and
Ki67 in intestinal
metaplasia and gastric
carcinoma . -
pubmed
Forty - seven
IM and thirty - seven gastric
carcinoma samples were stained for
p53 ,
c - erbB-2 and
Ki67 proteins by Envision immunohistochemical technique . -
pubmed
RESULTS : There were no significant differences in the expression of
p53 and
c - erbB-2 among
type I , type II , type III IM and gastric
carcinomas . -
pubmed
The positive expression rate of
Ki67 was significantly higher in gastric
carcinomas than in
type I IM while no significant
Ki67 expression differences were observed among
type II , type III IM and gastric
carcinomas . -
pubmed
The expression of
p53 ,
c - erbB-2 and
Ki67 proteins in 20
SIM , 27 Atypical
IM and 37 gastric
carcinomas showed significant differences between
SIM and gastric
carcinomas while no significant differences were observed between Atypical
IM and gastric
carcinomas . -
pubmed
Blood centers are implementing
TRALI risk reduction strategies based on screening apheresis donors for antibodies to
human leukocyte antigens (
HLA ) . -
pubmed
Effect of
TIMP-1 and
MMP in
pterygium invasion . -
pubmed
The migration and invasion of
tumor cells correlate with the interaction between
MMP and
TIMP . -
pubmed
Therefore , the purpose of this study was to determine the role of
MMP-9 ,
MMP-10 , and
TIMPs in
pterygium formation and progression . -
pubmed
Pterygium epithelial cells ( PECs ) , cultured in a serum - free culture medium , and siRNA were used to knock down
TIMP gene expression to understand the role of
TIMP in
pterygium invasion . -
pubmed
MMP-9 and
MMP-10 may each play a role in
pterygium formation , and
TIMPs may contribute to
pterygium invasion inhibition . -
pubmed
METHODS : In the acute
myocardial ischemia model , 40
Sprague - Dawley rats ( 8 weeks old , weight 200 - 250 g ) were successfully established with
isoproteronol (
ISO ) and randomly and evenly divided into 4 groups : Group G ( injected with glycosylated
G - CSF ) , Group N ( non - glycosylated
G - CSF ) , Group C ( [ control ] normal saline for 7 days ) , and Group M ( model ) . -
pubmed
At day 28 , the proportion of
CD34 + cells , myocardial
BrdU immunohistochemical stain , myocardial capillary density ,
myocardial fibrosis and cardiac function was detected among the 3 groups . -
pubmed
There are bases to think that
aldose reductase and
Bcl-2 protein are claimants to the role of end - effectors of delayed preconditioning but microRNAs serve as mediators of forming increased cardiac tolerance to
ischemia - reperfusion . -
pubmed
Chemokine - containing exosomes are released from heat - stressed
tumor cells via lipid raft - dependent pathway and act as efficient tumor vaccine . -
pubmed
In the
immunoglobulin ( Ig ) M - positive stage of
infection in blood donors when plasma
B19V DNA concentrations were greater than 100 IU / mL , median DNA concentrations were approximately 30 - fold higher in
WB than in plasma . -
pubmed
CONCLUSIONS : The WB - to - plasma
B19V DNA ratio varies by stage of
infection , with 30 - fold higher concentrations of
B19V DNA in WB relative to plasma during the
IgM - positive stage of
infection followed by comparable levels during persistent
infection when only
IgG is present . -
pubmed
Since then , no primary
thyroid small - cell carcinoma has been reported in the literature , with the exception of a case of a small - cell ( neuroendocrine )
carcinoma , an exceedingly rare
neoplasm akin to
medullary carcinoma , with expression of neuroendocrine markers but lacking
calcitonin immunoreactivity . -
pubmed
Beneficial effect of the
opioid receptor antagonist
naltrexone on hyper - sensitivity induced by
spinal cord ischemia in
rats : disassociation with
MK-801 . -
pubmed
However , even the effect of the highest dose of
naltrexone ( 20 mg / kg ) was incomplete , which is in contrast to the effect of the
NMDA receptor antagonist
MK-801 , which has been tested in the same model and found to completely prevent the incidence of
allodynia at a dose of 0.5 mg / kg . -
pubmed
The results suggest that
opioid receptor antagonists and
NMDA receptor antagonists prevent a consequence of transient
spinal cord ischemia through different mechanisms . -
pubmed
On the other hand , the
NMDA receptor may have a role in the secondary neuronal death resulting from
ischemia . -
pubmed
Thus ,
NMDA receptor antagonists may contribute to the prevention of
tissue damage by antagonizing the excitotoxic action of
glutamate and/or
aspartate released by
ischemia into the spinal cord . -
pubmed
Tissue factor over - expression by
human pancreatic cancer cells
BXPC3 is related to higher prothrombotic potential as compared to
breast cancer cells
MCF7 . -
pubmed
Cancer histology influences the risk of
venous thromboembolism and
tissue factor (
TF ) is the key molecule in
cancer - induced
hypercoagulability . -
pubmed
We investigated the relation between
TF expression by pancreatic and
breast cancer cells (
BXPC3 and
MCF7 respectively ) and their capacity to trigger in vitro
thrombin generation in normal
human plasma . -
pubmed
Activity of
TF expressed by
cancer cells was measured with a specific chromogenic assay . -
pubmed
The present study establishes a link between the amount of
TF expressed by
cancer cells with their procoagulant activity . -
pubmed
Both studied types of
cancer cells trigger
thrombin generation but they have different procoagulant potential . -
pubmed
TF expression is one of the mechanisms by which
cancer cells manifest their procoagulant potential but it is not the unique one . -
pubmed
Collectively , our findings provide a proof - of - concept for the ability of
man - made NPs to induce
insulin resistance in liver - derived cells , an
endocrine abnormality underlying some of the most common
human diseases . -
pubmed
[ Effect of
NR2E1 on the division and proliferation of
neuroblastoma cells ] . -
pubmed
RESULTS : At 48 h after the
neuroblastoma cells
IMR32 were transfected with
NR2E1 - shiRNA vector , the related nuclear division protein and the proliferation of the transfected cells
IMR32 were remarkably depressed . -
pubmed
To examine the diagnostic performance of cerebrospinal fluid - enzyme immunoassay (
CSF - EIA ) in
neurosyphilis , we conducted a prospective study for two years . -
pubmed
SIL1 , a causative cochaperone gene of
Marinesco - Sojgren syndrome , plays an essential role in establishing the architecture of the developing cerebral cortex . -
pubmed
Recently , mutations in the
SIL1 gene , encoding a co - chaperone which regulates the chaperone
HSPA5 , were identified as a major cause of
MSS . -
pubmed
We here examined the pathophysiological significance of
SIL1 mutations in abnormal corticogenesis of
MSS . -
pubmed
While RNAi - resistant
SIL1 rescued the defects , three
MSS - causing
SIL1 mutants tested did not . -
pubmed
Redistribution of demethylated
RNA helicase A during
foot - and - mouth disease virus infection : role of
Jumonji C - domain containing protein 6 in
RHA demethylation . -
pubmed
CCL2 [
chemokine ( C - C motif ) ligand 2 ] contributes to the
inflammation - induced
neuropathic pain through activating
VGSC (
voltage - gated sodium channel)-mediated nerve impulse conduction , but the underlying mechanism is currently unknown . -
pubmed
Fibrin is a protein polymer that forms a 3D filamentous network , a major structural component of protective physiological blood clots as well as life threatening pathological
thrombi . -
pubmed
Once mostly considered inexorable ,
renal disease progression can now be halted and lesions can even regress with drugs such as
angiotensin - converting enzyme inhibitors ( ACEi ) and
angiotensin II type I receptor blockers , indicating the possibility of kidney repair . -
pubmed
The
CXCR4 /
SDF-1 and
Ang II / AT1 receptor pathogenic pathways both pave the way for lesion formation and subsequent
sclerosis . -
pubmed
ACEi normalize the
CXCR4 and
AT1 receptor expression on progenitors , limiting their proliferation , concomitant with the regression of
hyperplastic lesions in
animals , and in a
patient with
crescentic glomerulopathy . -
pubmed
Moreover an increase of
CYP1A1 ( homologue to
human CYPIA 1 ) mRNA level may not only reduce the
carcinogenicity of foreign compounds , but may also activate some compounds to their
carcinogenicity In case of transporters , it is considered that an increase of their expression in the body may lead to increased fetoprotection . -
pubmed
Antioxidant status and serum levels of
selectins in
pre - eclampsia . -
pubmed
In
patients over the age of 30 years , serum levels of
L - selectin and
E - selectin were lower in pre -
eclamptic patients ( p & lt ; 0.05 ) ; antioxidants ,
catalase and
superoxide dismutase did not significantly differ between the two groups , while
glutathione peroxidase was significantly higher in the normotensive group ( p & lt ; 0.05 ) . -
pubmed
In
patients under the age of 30 years ,
E - selectin was significantly higher in the pre -
eclampsia group ( p & lt ; 0.05 ) , while
P - selectin ,
catalase and
superoxide dismutase were not significantly different between the two groups ( p & gt ; 0.05 ) . -
pubmed
Estrogens are known that they may produce
breast cancer by actions on
ER and also as chemical
carcinogens , as a consequence of their oxidation leading to reactive metabolites . -
pubmed
Renal fibrosis is mainly characterized by activation and proliferation of interstitial fibroblasts and by excessive synthesis and accumulation of extracellular matrix ( ECM ) components , including
fibronectin (
FN ) and
collagen . -
pubmed
These results suggest that
curcumin treatment ameliorates
renal fibrosis by reducing fibroblast proliferation and ECM accumulation mediated by
PPAR - gamma and
Smad - dependent
TGF - beta1 signaling . -
pubmed
Additionally , there were no detectable increases in the number of
necrotic muscle fibers or
CD68 + M1 macrophages . -
pubmed
Under EE - challenged conditions , significant increases in muscle fiber
necrosis ,
CD68 + M1 macrophage distribution , and
3 - nitrotyrosine were absent in
rats that received low and medium doses ( 20 and 60 mg / kg ) of DS treatment , suggesting that DS possess anti - inflammatory action protecting against a muscle - damaging challenge . -
pubmed
NKT cell - targeted vaccination plus
anti-4 - 1BB antibody generates persistent
CD8 T cell immunity against
B cell lymphoma . -
pubmed
The objective of this study was to increase the potency and durability of vaccine - induced immunity against
B cell lymphoma by combining
alpha - galactosylceramide (
alpha - GalCer)-loaded
tumor cell vaccination with an agonistic antibody targeting the immune checkpoint molecule
4 - 1BB (
CD137 ) . -
pubmed
We observed potent synergy when combining vaccination and
anti-4 - 1BB antibody treatment resulting in significantly enhanced survival of
mice harboring Emu - myc
tumors , including complete eradication of
lymphoma in over 50 % of
mice . -
pubmed
Tumor - free survival required
interferon gamma (
IFNgamma)-dependent expansion of CD8 + T cells and was associated with
4 - 1BB - mediated differentiation of
KLRG1 + effector CD8 + T cells . ' -
pubmed
Overall , our results demonstrate that therapeutic anticancer vaccination against
B cell lymphoma using an NKT cell ligand can be boosted by subsequent co - stimulation through
4 - 1BB leading to a sustainable immune response that may enhance outcomes to conventional treatment . -
pubmed
There is great success using
HLA - matched related donors for these patients ; however , the use of alternative donors has been associated with increased graft failure ,
graft - versus - host disease (
GVHD ) , and transplant - related mortality ( TRM ) . -
pubmed
HSCT using alternative donors with post - transplantation
cyclophosphamide ( PT / Cy ) for
GVHD prophylaxis has been performed for
hematologic malignancies with engraftment ,
GVHD , and TRM comparable with that seen with
HLA - matched related donors . -
pubmed
miR-181a negatively regulates
NF - kappaB signaling and affects activated B - cell - like diffuse large
B - cell lymphoma pathogenesis . -
pubmed
Remarkably , these effects are augmented in the
NF - kappaB dependent ABC - like subgroup compared with the GC B - cell ( GCB)-like
DLBCL subgroup . -
pubmed
We link these outcomes to relatively lower endogenous miR-181a expression and to
NF - kappaB signaling dependency in the ABC - like
DLBCL subgroup . -
pubmed
Our findings indicate that miR-181a inhibits
NF - kappaB activity , and that manipulation of miR-181a expression in the ABC - like
DLBCL genetic background may result in a significant change in the proliferation and survival phenotype of this malignancy . -
pubmed
Association between two single base polymorphisms of
intercellular adhesion molecule 1 gene and
inflammatory bowel disease . -
pubmed
AIM : The present study evaluated the association between G241R and K469E polymorphisms of
intercellular adhesion molecule 1 gene and
inflammatory bowel disease in Iranian population . -
pubmed
There are two single base polymorphisms of
intercellular adhesion molecule 1gene , G241R and K469E , reported to be associated with
inflammatory disorders . -
pubmed
CONCLUSION : According to our findings , K469E polymorphism of
intercellular adhesion molecule 1 gene may probably participate in the pathogenesis of
Crohn ' s disease in Iran . -
pubmed
NAFLD was independently associated with BMI more than 25 kg / m [ adjusted odds ratio ( aOR ) 4.86 , 95 % confidence interval ( CI ) 2.55 - 9.26 ] and elevated
alanine aminotransferase (
ALT ) ( aOR 3.17 , 95 % CI 1.43 - 7.03 ) . -
pubmed
Independent predictors of significant
liver fibrosis were
diabetes ( aOR 5.84 , 95 % CI 1.91 - 17.85 ) , elevated
ALT ( aOR 3.30 , 95 % CI 1.27 - 8.59 ) and current use of protease inhibitors ( aOR 3.96 , 95 % CI 1.64 - 9.54 ) . -
pubmed
Lower
Erythropoietin Doses and Medicare Payment Reform : Win - Wins for Patients With
End - stage Renal Disease . -
pubmed
NLRP3 inflammasome : common nexus between
depression and
cardiovascular diseases . -
pubmed
IgE - ADA was determined in three retrospective cohorts ( n=159 ) containing IR+ ( n=37 ) and IR- ( n=39 ) , and longitudinal sera of 83
spondyloarthritis . -
pubmed
RESULTS :
IgE - ADA was found in 0/39 IR- , whereas 4/37 ( 11 % ) IR+ showed low levels ( 0.1 - 0.3 IU / mL , below the 0.35 IU / mL threshold associated with elevated risk of
allergic symptoms ) . -
pubmed
The incidence of
IgE - ADA in
patients with infliximab - treated
spondyloarthritis was estimated at less than approximately 1 % . -
pubmed
High expression of
EphA3 (
erythropoietin - producing hepatocellular A3 ) in
gastric cancer is associated with metastasis and poor survival . -
pubmed
BACKGROUND : As the major subfamily of
receptor tyrosine , erythropoietin - producing hepatocellular ( Eph ) receptor has been related to progression and prognosis in different types of
tumors . -
pubmed
However , the role and mechanism of
EPHA3 in
gastric cancer is still not well understood . -
pubmed
We analyzed the clinicopathological factors and prognostic relevance of
EphA3 expression in
gastric cancer . -
pubmed
RESULTS : High expression of
EphA3 was associated with male predominance ( p = 0.031 ) , differentiated histology ( p & lt ; 0.001 ) , depth of
tumor ( p = 0.002 ) , lymph node metastasis ( p = 0.001 ) , distant metastasis ( p = 0.021 ) , liver metastasis ( p = 0.024 ) , advanced stage ( p & lt ; 0.001 ) , and high
HER2 expression ( p = 0.017 ) . -
pubmed
Multinomial logistic regression estimated separate ORs for each subtype by the exposures parity , age at first birth , breastfeeding , menarche , hormone replacement therapy use , somatotype at age 18 ,
benign breast disease , mammographic density , polygenic risk score , family history of
breast cancer , and
BRCA mutations . -
pubmed
The new
kisspeptin derivative -
kissorphin (
KSO ) - attenuates acute
hyperlocomotion and sensitization induced by
ethanol and
morphine in
mice . -
pubmed
Previous studies of
monoHAA - induced
genotoxicity and cell stress demonstrated that the toxicity was due to inhibition of
glyceraldehyde-3 - phosphate dehydrogenase (
GAPDH ) , leading to disruption of cellular metabolism and energy homeostasis . -
pubmed
Hepatitis B virus infection in Taiwan : The role of
NTCP rs2296651 variant in relation to sex . -
pubmed
Sodium taurocholate cotransporting polypeptide (
NTCP ) is a functional receptor for
hepatitis B virus ( HBV ) infection . -
pubmed
Gender - stratified multivariate logistic regression models were used to determine the relationship between
NTCP variant and
HBV infection . -
pubmed
We found that genetic variation in the
HBV receptor gene (
NTCP ) was significantly associated with a decreased risk of
HBV infection in Taiwanese women . -
pubmed
HIV - related parameters such as
CD4 cell counts , duration of
HIV infection and HAART regimen did not seem to contribute towards an adverse surgical outcome . -
pubmed
Background :
Angelman syndrome is a rare
neurodevelopmental disorder characterized by
intellectual disability , severe
speech impairment ,
ataxia ,
seizures ,
happy demeanor , distinctive craniofacial features ,
high vagal tone , and
gamma - amino butyric acid receptor abnormalities . -
pubmed
Transmembrane - type 2 matrix metalloproteinase (
MT2 - MMP ) degrades connective extracellular matrix between cells and enables
tumor cells to migrate and metastasize , making this substance a potential therapeutic target in various diseases . -
pubmed
This work illustrated that common trivalent metal ions can potentially inhibit
MT2 -
MMP - related
tumors . -
pubmed
Risk stratification and role for additional diagnostic testing in patients with acute
chest pain and normal high - sensitivity cardiac
troponin levels . -
pubmed
BACKGROUND : Normal high sensitivity
cardiac troponin ( hs -
cTn ) assays rule out
acute myocardial infarction (
AMI ) with great accuracy , but additional non - invasive testing is frequently ordered . -
pubmed
METHODS : 918 serial
patients with acute
chest pain and normal hs -
cTnT levels were prospectively included . -
pubmed
A recent abnormal stress test , suspicious history , a
positive family history and higher baseline hs -
cTnT levels were independent predictors of
MACE with odds ratios of 16.00 ( 95%CI:6.25 - 40.96 ) , 16.43 ( 6.36 - 42.45 ) , 2.33 ( 1.22 - 4.42 ) and 1.10 ( 1.01 - 1.21 ) , respectively . -
pubmed
CONCLUSIONS : Clinical characteristics can be used to identify low risk
patients with acute
chest pain and normal
hs - cTnT levels . -
pubmed
MMP9 is an inflammatory biomarker that increases during progression to
endometriosis . -
pubmed
Author Correction : Variants in exons 5 and 6 of
ACTB cause
syndromic thrombocytopenia . -
pubmed
Serum
PG levels were positively correlated with metagenomic functional capacities for
bacterial LPS synthesis and host markers of
low - grade inflammation ; transcriptome databases identified
PG synthase , the first committed enzyme in
PG synthesis , as a potential mediator . -
pubmed
Furthermore , during oral
glucose and
insulin tolerance tests , FO from
dyslipidaemic dams exhibited altered
glucose tolerance and
insulin sensitivity ( P & lt ; 0.05 ) when compared with FO from CTL dams . -
pubmed
In such conditions ,
rocuronium remains able to cause
immunoglobulin E cross - linkage and the
anaphylaxis mechanism can continue . -
pubmed
Intradermic skin tests confirmed
rocuronium immunoglobulin E - mediated
anaphylaxis but also showed intradermal injection of mixing in equal molecular ratio of
sugammadex with
rocuronium preventing
rocuronium anaphylactic skin reaction . -
pubmed
BACKGROUND : The
apolipoprotein E (
APOE ) genotype provides information about
Alzheimer ' s disease risk , yet genotype disclosure is discouraged due to concerns about possible distress . -
pubmed
Circular RNA ciRS-7 promotes the proliferation and metastasis of
pancreatic cancer by regulating miR-7 - mediated
EGFR /
STAT3 signaling pathway . -
pubmed
ciRS-7 expression was also significantly elevated in venous invasion ( 3.72 + - 2.93 vs. 2.14 + - 1.26 ; P = 0.028 ) and lymph node metastasis ( 4.19 + - 2.75 vs. 2.32 + - 1.90 ; P = 0.016 ) in
PDAC patients . -
pubmed
Furthermore , ciRS-7 knockdown suppressed cell proliferation and invasion of
PDAC cells ( P & lt ; 0.05 ) , and the downregulation of
ciRS-7 resulted in miR-7 overexpression and subsequent inhibition of
epidermal growth factor receptor (
EGFR ) and
signal transducer and activator of transcription 3 (
STAT3 ) . -
pubmed
CONCLUSIONS : Circular RNA ciRS-7 plays an oncogene role in
PDAC , partly by targeting miR-7 and regulating the
EGFR /
STAT3 signaling pathway . -
pubmed
Triglyceride deposit cardiomyovasculopathy (
TGCV ) is a phenotype primarily reported in patients carrying genetic mutations in
PNPLA2 encoding
adipose triglyceride lipase (
ATGL ) which releases long chain
fatty acid (
LCFA ) as a major energy source by the intracellular TG hydrolysis . -
pubmed
Moreover , we identified
TGCV patients without
PNPLA2 mutations based on pathological and clinical studies . -
pubmed
We provided the diagnostic criteria , in which
TGCV with and without
PNPLA2 mutations were designated as primary
TGCV ( P - TGCV ) and
idiopathic TGCV ( I - TGCV ) , respectively . -
pubmed
Patients with I - TGCV , of which etiologies and causes are not known yet , suffered from adult - onset severe
heart disease , including
heart failure and
coronary artery disease , associated with a marked reduction in
ATGL activity and myocardial washout rate of
LCFA tracer , as similar to those with P - TGCV . -
pubmed
The lymphocytes from bone marrow of
multiple myeloma patients as well as
myeloma cell lines - RPMI 8226 and
U266 B1 express
APase activity constitutively . -
pubmed
We investigated the distribution and progression of
LRP and its relation to
AD pathology and
apolipoprotein ( APOE ) epsilon4 in a population - based sample of Finns aged over 85 years ( N = 304 ) . -
pubmed
LRP was present in 124
individuals ( 41 % ) and according to
DLB Consortium guidelines 19 of them were categorized as brainstem , 10 amygdala - predominant , 41 limbic , and 43 diffuse neocortical type , whereas 11 could not be classified . -
pubmed
Severe Braak
NFT stage , high CERAD score and
APOE epsilon4 were significantly ( all p & lt ; 0.00001 ) associated with amygdala - based , but not with caudo - rostral progression type ( all p & gt ; 0.2 ) . -
pubmed
The amygdala - based pattern was associated with
APOE epsilon4 and
AD pathology . -
pubmed
Netrin-1 and its receptor
DCC are causally implicated in
melanoma progression . -
pubmed
Deleted in
Colorectal Cancer (
DCC ) , the receptor for the multifunctional cue
netrin-1 , acts as a tumor suppressor in intestinal
cancer and lung metastasis by triggering
cancer cell death when
netrin-1 is lowly expressed . -
pubmed
Recent genomic data highlighted that
DCC is the third most frequently mutated gene in
melanoma , we therefore investigated whether
DCC could act as a
melanoma tumor suppressor . -
pubmed
Re - expressing
DCC in
human melanoma cell lines promoted
tumor cell death and
tumor growth inhibition in xenograft
mouse models . -
pubmed
Genetic silencing of
DCC pro - death activity in a
BRAFV600E mouse model increased the proportion of
mice with
melanoma , further supporting that
DCC is a
melanoma tumor suppressor . -
pubmed
Netrin-1 expression was elevated in
melanoma compared to benign
melanocytic lesions . -
pubmed
Upregulation of
Netrin-1 in the skin cells of a
BRAFV600E - mutated murine model reduced
cancer cell death and promoted
melanoma progression . -
pubmed
Therapeutic antibody blockade of
netrin-1 combined with
dacarbazine increased overall survival in several
mouse melanoma models . -
pubmed
Together these data support that interfering with
netrin-1 could be a viable therapeutic approach in
patients with
netrin-1 - expressing
melanoma . -
pubmed
More recently , advancement in molecular exploration of BTC has shed light on the complex biological heterogeneity within these
tumours and has also identified actionable genomic aberrations , such as
fibroblast growth factor receptor 2 (
FGFR2 ) gene fusions ,
isocitrate dehydrogenase (
IDH ) and
BRAF mutations , which offer promise with the anticipation of increased responses and durable clinical benefit in selected
patients . -
pubmed
The origin of
PNH is the somatic mutation in the X - linked
phosphatidylinositol glycan class A (
PIG - A ) gene located on Xp22 : this condition leads to the production of clonal blood cells with a deficiency in those surface proteins that protect against the lytic action of the activated complement system . -
pubmed
A
human induced pluripotent stem cell ( iPSC ) line was generated from peripheral blood mononuclear cells ( PBMCs ) in a patient with
intellectual disability and carrying a haploinsufficiency for
PLPPR4 . -
pubmed
This iPSC line offers a useful resource to investigate the pathogenesis and molecular mechanisms involved in
PLPPR4 - related
ID . -
pubmed
Nlrp3 inflammasome , a key contributor in the pathogenesis of
angina pectoris , requires activation and primary signaling for the commencement of
inflammation . -
pubmed
Morphine-3 - glucuronide upregulates
PD - L1 expression via
TLR4 and promotes the immune escape of
non - small cell lung cancer . -
pubmed
Methods : The effects of
M3 G on
PD - L1 expressions in
human non - small cell lung cancer (
NSCLC ) cell lines were first evaluated . -
pubmed
The effects of
M3 G on
human cytotoxic T lymphocytes ( CTL )
cytotoxicity and
INF - gamma release was also detected . -
pubmed
M3 G inhibited the
cytotoxicity of CTL on
A549 cells and decreased the level of
INF - gamma . -
pubmed
Repeated
M3 G intraperitoneal injections promoted LLC
tumor growth and lung metastasis through the upregulation of
tumor expressed
PD - L1 and the reduction of CTL in the
tumor microenvironment . -
pubmed
Conclusions :
M3 G specifically activated
TLR4 in
NSCLC cells and upregulated
PD - L1 expression through the
PI3 K signaling pathway , thereby inhibiting CTL cytotoxicity and finally promoting
tumor immune escape . -
pubmed
Concanavalin A inhibition of
ecto-5 '- nucleotidase of intact cultured
C6 glioma cells . -
pubmed
A pronounced effect of concanavalin A ( Con A ) upon activity of
ecto-5 '- nucleotidase of intact
C6 glioma cells in culture has been demonstrated . -
pubmed
Preincubation at 42 degrees , before
infection at permissive temperature by phage lambda , of an
Escherichia coli dnaB mutant , provokes a significant increase in survival and mutagenesis of ultraviolet irradiated phage as well as mutagenesis of untreated phage . -
pubmed
Abnormal
lipoprotein - lipase - mediated plasma
triglyceride removal in untreated
diabetes mellitus associated with
hypertriglyceridemia . -
pubmed
An abnormality in the interaction of
lipoprotein lipase with endogenous circulating plasma lipoprotein
triglyceride has been demonstrated in untreated
diabetes . -
pubmed
These
diabetics have a decreased maximal removal capacity for plasma
triglyceride ( 27.0 mg TG / kh / hr ) and increased Km ( 390 mg / dl ) for endogenous plasma
triglyceride -
lipoprotein lipase interaction compared to that found in nondiabetic
hypertriglyceridemic subjects ( Vmax , 32.0 ; km , 157 ) . -
pubmed
The
double - stranded RNA - dependent 2 ' , 5 '- oligoadenylate ( 2 - 5A ) synthetase /
ribonuclease L (
RNase L ) system plays an essential role in the establishment of the antiviral state of a cell exposed to
virus infection . -
pubmed
Two new strategies have been developed which yield a selective antiviral effect of 2 - 5As at least against
human immunodeficiency virus-1 ( HIV-1 ) infection : ( i ) an " intracellular immunization " approach using
2 - 5A synthetase cDNA linked to HIV trans - acting response element ( TAR ) and ( ii ) inhibition of
retroviral reverse transcriptase activity by 2 - 5A analogues . -
pubmed
Intracerebroventricular infusions of
insulin ( 4 and 40 micrograms / min for 30 min ) increased plasma
AVP concentrations dose - dependently without
hypoglycaemia , but decreased hypothalamic and pituitary contents of AVP . -
pubmed
The decreased threshold for
strychnine - induced
seizures and
myoclonus in the 3AP - inferior olive - lesioned
rats may be due to an increase in
glutamate receptors as suggested by the
[ 3H ] AMPA binding data . -
pubmed
Thus :
beta - adrenergic receptor density increases during relatively early stages of
injury in metabolically impaired myocytes with reduced
adenosine triphosphate levels and decreases subsequently , after the myocytes become irreversibly injured ; the increased
beta - adrenergic receptor density in moderately injured myocytes can be reversed upon removal of the injurious agent and restoration of the cellular
adenosine triphosphate level ; and changes in
catecholamines mediated by an intact nervous system are not required for an increase in
beta - adrenergic receptor density in the setting of impaired energy metabolism . -
pubmed
Site - specific mutagenesis was used to introduce
amino acid substitutions at the
asparagine codons of four conserved potential N - linked glycosylation sites within the
gp120 envelope protein of
human immunodeficiency virus (
HIV ) . -
pubmed
[ Application of
fibrin adhesive in the surgery of complex
renal lithiasis ] . -
pubmed
It has been shown previously that the amyloid fibrils in one form of
senile amyloidosis affecting the heart contains a
prealbumin - related protein ,
ASc1 . -
pubmed
It is shown in this paper by immunohistochemical study using a specific anti - protein
ASc1 antiserum that this type of
amyloidosis , previously called
senile cardiac amyloidosis , is a
systemic disease with amyloid deposits in many organs . -
pubmed
Evidence for a differential modulation of the
alpha-2 adrenoceptors by
angiotensin II in the nucleus tractus solitarii of the spontaneously
hypertensive and the Wistar - Kyoto normotensive
rats . -
pubmed
An interaction between
angiotensin II ( Ang II ) receptors and
alpha 2 - adrenoceptors was evaluated in the nucleus tractus solitarii ( NTS ) of the normotensive
Wistar - Kyoto rat ( WKY ) and of the spontaneously
hypertensive rat ( SHR ) using quantitative receptor autoradiography and cardiovascular analysis . -
pubmed
Tamoxifen is widely used as adjuvant therapy for postmenopausal
breast cancer patients with positive
estrogen receptors . -
pubmed
It may be concluded that relaxations elicited by hypercapnic
acidosis are associated with a fall of extracellular pH and an activation of the electrogenic
Na + pump , and those caused by hyperosmolarity are due to stimulation of the Na
(+)-H
+ exchange and the Na+ pump . -
pubmed
IgE - mediated
allergy from vegetable allergens . -
pubmed
Allergy to fresh
fruits and
vegetables is
IgE - mediated . -
pubmed
Fluorescence in situ hybridization ( FISH ) with satellite ( alpha , beta , classical ) , ribosomal DNA ,
alpha - interferon (
alpha - IFN ) , and whole chromosome painting probes indicated that the 9;15 rearrangement is dicentric in both
tumors . -
pubmed
Detection of
albumin messenger RNA in blood is not restricted to
hepatocellular carcinoma . -
pubmed
Protein kinase C (
PKC ) regulates keratinocyte growth and differentiation as well as
inflammation in skin , processes which are abnormal in
skin diseases such as
psoriasis . -
pubmed
We investigated the effects of
SCH 47112 , a novel
staurosporine derivative , which interacts with the catalytic domain of
PKC , on
TPA - induced
inflammation and
hyperplasia in hairless
mouse skin and
TPA - induced differentiation in cultured
human keratinocytes . -
pubmed
These results indicate that
SCH 47112 exhibits biological activity , inhibiting
TPA - induced changes in hairless
mouse skin in vivo and cultured
human keratinocytes in vitro , and suggest that
PKC inhibitors may have a therapeutic role in
inflammatory skin diseases . -
pubmed
Decrease in circulating and urine
adrenomedullin concentrations in
stroke - prone spontaneously
hypertensive rats . -
pubmed
Adrenomedullin ( AM ) is a peptide with potent vasodilatory and
hypotensive properties . -
pubmed
Effects of
poly ( ADP - ribose ) polymerase inhibition on cell death and
chromosome damage induced by
VP16 and
bleomycin . -
pubmed
Since apoptosis is important in
tumor treatment these findings might be useful when considering the combined employment of
PARP inhibition with antineoplastic drugs . -
pubmed
Expression of the
67 - kDa laminin receptor in
acute myeloid leukemia cells mediates adhesion to
laminin and is frequently associated with monocytic differentiation . -
pubmed
The
67 - kDa laminin receptor (
67LR ) is a nonintegrin protein with high affinity for
laminin , which plays a critical role in basement membrane invasion and metastasis of
cancer cells . -
pubmed
We did not detect
67LR expression in normal BM hematopoietic cells , in precursor - B
acute lymphoblastic leukemia , in
chronic lymphocytic leukemia , or in
chronic myeloid leukemia in chronic phase . -
pubmed
By contrast , we detected enhanced
67LR expression in 40 % of 53 de novo
acute myeloid leukemias (
AMLs ) , which frequently exhibited monocytic or myelomonocytic morphology and expressed
CD14 and
CD11a ( P & lt ; 0.05 ) . -
pubmed
Using a colorimetric assay , we found that the expression pattern of this receptor corresponded to a higher adhesion to
laminin ; the adhesion was specific because in vitro addition to
laminin - coated wells of recombinant 37 - kDa
laminin receptor precursor (
37LRP ) , which is the cytoplasmic precursor containing both
laminin - binding domains of
cell surface 67LR , significantly reduced
laminin binding of
AML cells . -
pubmed
The expression of
67LR on
AML cell surface did not correlate with other differentiation and
integrin antigens such as
CD7 ,
CD13 ,
CD33 ,
CD34 ,
CD11b ,
CD11c ,
CD49d ,
CD49e ,
CD45RA , and
CD45RO . -
pubmed
In contrast with
67LR behavior in
solid tumors , no statistically significant difference was found between
67LR expression and any hematological characteristic of the disease at diagnosis , nor between
67LR expression and outcome of the disease as measured by complete remission rate , disease - free survival , or overall survival . -
pubmed
In conclusion , our results indicate that
67LR expression mediates specific adhesion to
laminin and that the detection of this molecule may be a valuable addition to other lineage - associated antigens in identifying monocytic - oriented
AML . -
pubmed
Endothelial NO synthase (
eNOS ) generated
NO ( 140 + /- 20 nmol l(-1 ) ) in lung during the acute phase ( first 10 - 15 min ) of
endotoxemia , followed by production of
NO by inducible
NOS . -
pubmed
Severe
hypoglycemia and reduction of
insulin requirement in a
girl with
insulin - dependent diabetes mellitus : first sign of a
craniopharyngioma . -
pubmed
At 16 years she was found to have GH ,
gonadotropin ,
ACTH , and probably also
TSH deficiency with
hyperprolactinemia . -
pubmed
In this
girl , decreasing
insulin requirements represented an early manifestation of combined growth hormone and
cortisol deficiency . -
pubmed
KCNQ4 , a K+ channel mutated in a form of dominant
deafness , is expressed in the inner ear and the central auditory pathway . -
pubmed
Mutations in the
potassium channel gene
KCNQ4 underlie
DFNA2 , an autosomal dominant form of
progressive hearing loss in
humans . -
pubmed
Moreover , the expression pattern of
KCNQ4 in the
mouse auditory system raises the possibility of a central component in the
DFNA2 hearing loss . -
pubmed
It has been reported that
survivin is expressed during fetal development and in
cancer tissues , but its expression has not been reported in adult tissues . -
pubmed
Vascular release of
plasminogen activator inhibitor-1 impairs fibrinolysis during acute arterial
thrombosis in
mice . -
pubmed
The role of
plasminogen activator inhibitor-1 (
PAI-1 ) in the plasma , blood platelets , and vessel wall during acute arterial
thrombus formation was investigated in gene - deficient
mice . -
pubmed
In comparison to
thrombosis in C57BL/6J wild - type ( wt )
mice ( 113 + /- 19 x 10(6 ) arbitrary light units [ AU ] n = 15 , mean + /- SEM ) ,
thrombosis in
PAI-1(-/- )
mice ( 40 + /- 10 x 10(6 ) AU , n = 13 ) was inhibited ( P & lt;.01 ) , indicating that
PAI-1 controls fibrinolysis during
thrombus formation . -
pubmed
Systemic administration of
murine PAI-1 into
PAI-1 (-/- ) mice led to a full recovery of
thrombotic response . -
pubmed
The sizes of
thrombi developing in wt
mice , in
alpha ( 2 )- AP(+/- ) and
alpha ( 2 )- AP(-/- )
mice were 102 + /- 35 , 65 + /- 8.1 , and 13 + /- 6.1 x 10(6 ) AU , respectively ( n = 6 each ) ( P & lt;.05 ) , compatible with functional
plasmin inhibition by
alpha ( 2 )- AP . -
pubmed
In contrast ,
thrombi in wt
mice ,
t - PA(-/- ) and
u - PA(-/- )
mice were comparable , substantiating efficient inhibition of fibrinolysis by the combined
PAI-1 /
alpha ( 2 )- AP action . -
pubmed
Platelet depletion and reconstitution confirmed a normal
thrombotic response in wt
mice , reconstituted with
PAI-1(-/- ) platelets , but weak
thrombosis in
PAI-1 (-/- ) mice reconstituted with wt platelets . -
pubmed
Hence , during acute
thrombosis , fibrinolysis is efficiently prevented by plasma
alpha ( 2 )- AP , but also by vascular
PAI-1 , locally released into the circulation after
endothelial injury . -
pubmed
Other novel agents being evaluated in the treatment of
patients with advanced
CRC include oral edrecolomab (
monoclonal antibody 17 - 1A ) and
tumour vaccines . -
pubmed
Quantitative correlation of
cytokeratin 19 mRNA level in peripheral blood with disease stage and metastasis in
breast cancer patients : potential prognostic implications . -
pubmed
We determined the circulating
tumor burden in
BC patients by semiquantitative reverse transcription - polymerase chain reaction using
carcinoembryonic antigen (
CEA ) and
cytokeratin 19 (
CK19 ) mRNAs as molecular markers . -
pubmed
We found
CEA mRNA in 97 % of
patients and 92 % of
normal controls , and
CK19 mRNA in 72 % of
patients and 19 % of controls . -
pubmed
CEA and
CK19 mRNAs in
normal peripheral blood were most likely derived from illegitimate transcription . -
pubmed
In 10
patients , of whom 9 ( 90 % ) developed systemic metastases , the upper limit of
CK19 mRNA of
normal controls was exceeded . -
pubmed
As compared with
normal controls , significantly elevated
CK19 mRNA levels in the
patients appeared to originate from circulating malignant
BC cells ( P<0.0001 ) . -
pubmed
Of prognostic value , we report for the first time that
BC patients with
CK19 mRNA elevation had notably shorter ( approximately 3 - year reduction ) overall survival than
patients with normal
CK19 mRNA levels ( P=0.045 ) . -
pubmed
Quantification of
CK19 mRNA may prove useful for
cancer staging , disease monitoring and prognostic assessment among
BC patients . -
pubmed
Hematoxylin - eosin , Masson 's trichrome , and immunohistochemical stainings for
Ulex europaeus I lectin binding ,
CD31 , and
type IV collagen were done to differentiate lymphatic and blood vessels and to demonstrate basement membranes in vascular walls and around
carcinoma cell nests was observed . -
pubmed
Conversion to a LFCC diet for 2 months led to normalization of
glucose transport , blood pressure , plasma
insulin , and
VLDL - C and significant amelioration of
obesity and other
lipid abnormalities . -
pubmed
Localization of
metallothionein in
urothelial carcinoma of the human urinary bladder : an immunohistochemical study including correlation with
HLA - DR antigen ,
p53 , and proliferation indices . -
pubmed
In this study
MT expression was detected immunohistochemically , using a monoclonal antibody ( E9 ) against a conserved epitope of I and II isoforms , in a series of 63 cases of
urothelial carcinomas of the urinary bladder . -
pubmed
Correlation between
MT expression and
HLA - DR antigen expression ,
p53 , proliferation indices (
PCNA and MIBI ) as well as the various clinicopathological parameters , such as age , sex ,
squamous metaplasia ,
tumor grade , stage and recurrence were studied . -
pubmed
In a semiquantitative analysis
MT expression ( & gt ; 10 % of neoplastic cells ) was observed in 12.7 % , focal
MT positivity in 11.1 % and almost completely lack of
MT expression in 76.2 % of
tumors . -
pubmed
The incidence of
MT expression was significantly higher ( p=0.0002 ) in cases with high pathological
tumor grades . -
pubmed
The data suggested that
MT expression was correlated with a more aggressive behavior in
urothelial bladder cancer . -
pubmed
OBJECTIVE : To generate and characterize anti - idiotypic monoclonal antibody (
Ab2 ) that bears the internal image of
nasopharyngeal carcinoma (
NPC ) associated antigen . -
pubmed
Mice immunized with 2H4 or 5D3 coupled with
keyhole limpet hemocyanin (
KLH ) , showed a positive and specific
delayed - type hypersensitivity ( DTH ) reaction after stimulation by NPC cells . -
pubmed
Alpha1 - acid glycoprotein expressed in the plasma of
chronic myeloid leukemia patients does not mediate significant in vitro resistance to
STI571 . -
pubmed
At all stages of
CML ,
AGP plasma level was significantly higher than in normal controls ( P & lt;.05 ) . -
pubmed
Heparin cofactor II inhibits
arterial thrombosis after
endothelial injury . -
pubmed
HCII has been proposed to regulate coagulation or to participate in processes such as
inflammation ,
atherosclerosis , and
wound repair . -
pubmed
These observations suggest that
HCII might inhibit
thrombosis in the arterial circulation . -
pubmed
If
patients developed
MTX resistance or
toxicity , treatment was altered according to the level of
beta human chorionic gonadotropin (
hCG ) . -
pubmed
hCG values normalized in 324 ( 66.8 % ) of 485
patients with
MTX alone , whereas 161 ( 33.2 % ) of 485 patients required a change in treatment , 11 because of
MTX toxicity and 150 because of
MTX resistance . -
pubmed
CONCLUSION : Single - agent
dactinomycin has activity in
patients with low - risk
GTD who develop
MTX resistance and whose
hCG is low . -
pubmed
Pseudomyxoma peritonei is a disease of
MUC2 - expressing goblet cells . -
pubmed
Our studies revealed that
pseudomyxoma peritonei is a disease of
MUC2 - expressing goblet cells . -
pubmed
These cells also express
MUC5AC but the latter
mucin is not specific for
pseudomyxoma peritonei . -
pubmed
MUC2 expression accounts for the voluminous deposits of extracellular mucin ( mucin : cell ratios exceeding 10:1 ) and distinguishes
pseudomyxoma peritonei secondarily involving the ovary from primary
ovarian mucinous tumors with peritoneal implants . -
pubmed
Because
mucinous tumors of the appendix similarly express
MUC2 , the
MUC2 expression profile also supports an appendiceal rather than ovarian origin for
pseudomyxoma peritonei . -
pubmed
Primary epithelial cell cultures obtained from
pseudomyxoma peritonei express
MUC2 whose levels can be epigenetically regulated . -
pubmed
Both immunocytochemical as well as in situ hybridization studies with ancillary digital image analysis reveal that
MUC2 expression in cases of
pseudomyxoma peritonei is independent of the degrees of malignant transformation that are present and , in fact , reflects the constitutive levels of expression observed in normal goblet cells of the appendix . -
pubmed
Extracellular
mucin accumulates dramatically in
pseudomyxoma peritonei because the number of
MUC2 - secreting cells dramatically increase and because this
MUC2 has no place to drain . -
pubmed
These studies suggest that
pseudomyxoma peritonei should be regarded as a disease of
MUC2 - expressing goblet cells whose
MUC2 expression might be susceptible to pharmacological targeting . -
pubmed
After
rats on gestation day 10 exposed to
hyperthermia(40 degrees C ) for 0.5 , 1.0 , 2.5 and 5.0 h ,
red - cell C3b receptor activity(aggregate ) , red - cell immune complex , circulating immune complex ,
Nile blue sulfate (
NBS ) vital staining , electronic microscope and histochemical techniques were used in investigate whether the
hyperthermia was disturb red - cell immune functions of pregnant
rats and played some role in teratogenesis . -
pubmed
The results showed that
hyperthermia increased the level of
red - cell C3b receptor activity , red - cell immune complex and circulating immune complex . -
pubmed
[
B - type natriuretic peptide and
cardiovascular disease ] . -
pubmed
Is
systemic disease in the coelomic epithelium associated with
BRCA1 germline mutations ? -
pubmed
Besides typical central effects of
cannabinoids ,
CB1 receptor activation leads to
hyperphagia , whereas its pharmacological blockade is followed by changes in energy metabolism favouring substrate oxidation . -
pubmed
Angiotensin - converting enzyme 2 protects from severe
acute lung failure . -
pubmed
Here we report that
ACE2 and the
angiotensin II type 2 receptor (
AT2 ) protect
mice from severe
acute lung injury induced by acid aspiration or
sepsis . -
pubmed
However , other components of the
renin -
angiotensin system , including
ACE ,
angiotensin II and the
angiotensin II type 1a receptor (
AT1a ) , promote disease pathogenesis , induce
lung oedemas and impair lung function . -
pubmed
We show that
mice deficient for
Ace show markedly improved disease , and also that recombinant
ACE2 can protect
mice from severe
acute lung injury . -
pubmed
Our data identify a critical function for
ACE2 in
acute lung injury , pointing to a possible therapy for a syndrome affecting millions of
people worldwide every year . -
pubmed
ERBB2 kinase domain mutation in the
lung squamous cell carcinoma . -
pubmed
Recent reports revealed that the kinase domain of
ERBB2 gene , a proto - oncogene , is somatically mutated in the
lung adenocarcinomas , suggesting the mutated
ERBB2 gene may act as an oncogene in
human cancers . -
pubmed
The purpose of this was to see whether the
ERBB2 kinase domain is mutated in other
lung cancer types besides the
adenocarcinoma . -
pubmed
Here , we performed mutational analysis of the
ERBB2 kinase domain by polymerase chain reaction - single strand conformation polymorphism assay in 114 non - adenocarcinoma type
non - small cell lung cancers (
NSCLCs ) tissue samples , including 100
squamous cell carcinomas , three
adenosquamous carcinomas and 11
large cell carcinomas . -
pubmed
We detected the
ERBB2 kinase domain mutation in one
squamous cell carcinoma ( 1.0 % ) . -
pubmed
We simultaneously analyzed the somatic mutations of
EGFR ,
K - RAS ,
PIK3CA and
BRAF genes in the
squamous cell carcinoma with the
ERBB2 mutation , and found that the
tumor did not harbor any
EGFR or
ERBB2 or
K - RAS or
PIK3CA or
BRAF gene mutation , either . -
pubmed
This study demonstrated that in addition to
lung adenocarcinoma ERBB2 kinase domain mutation could occur in
lung squamous cell carcinomas , and suggested that alterations of
ERBB2 - mediated signaling pathway by
ERBB2 mutations may occasionally contribute to the development of
lung squamous cell carcinomas . -
pubmed
Comparative activity of
Sant7 and anti -
IL-6 ,
IL-6R monoclonal antibodies in a
murine model of
B - cell lymphoma . -
pubmed
Interleukin-6 (
IL-6 ) plays a central role in the pathogenesis of several
autoimmune and inflammatory diseases as well as
B - cell lymphoproliferative disorders . -
pubmed
This work describes the effects of the recombinant or adenovirally - delivered
IL-6 superantagonist Sant7 , anti -
IL-6 and
IL-6 receptor monoclonal antibodies in a severe
murine model of
human B - cell lymphoma induced in
SCID mice by transplantation of an
LCL-41 cell line variant ( isotype - switched
IgM>
IgG ) . -
pubmed
Overall , the present data suggest a potential for anti -
hIL-6 therapy in
B - cell lymphomas . -
pubmed
To the best of our knowledge , our case is the second case of
extraskeletal Ewings sarcoma arising from the broad ligament but the first case that is confirmed by strong
CD99 positivity and supported by fluorescence in situ hybridization . -
pubmed
Mutations in the
Neurofibromatosis 2 (
NF2 ) gene are associated with predisposition to
vestibular schwannomas ,
spinal schwannomas ,
meningiomas , and
ependymomas . -
pubmed
Presently , how
NF2 is expressed during embryonic development and in the tissues affected by
neurofibromatosis type 2 (
NF2 ) has not been well defined . -
pubmed
The
NF2 promoter expression pattern during embryogenesis suggests a specific regulation of the
NF2 gene during neural crest cell migration and further supports the role of
merlin in cell adhesion , motility , and proliferation during development . -
pubmed
This article describes recent developments in sex - related differences in opioid (
morphine ) pharmacodynamics ,
morphine metabolites , the
nociceptin / orphanin FQ receptor system , acute opioid tolerance and opioid - induced side - effects , such as opioid - induced
respiratory depression and itch , and
P - glycoprotein modulation of opioid effect . -
pubmed
High dose
CHOP : a phase II study of initial treatment in aggressive
non - Hodgkin lymphoma . -
pubmed
Choriocarcinoma of testes is a very rare
tumor with poor prognosis , usually presenting with high serum level of
human chorionic gonadotropin (
hCG>50,000 mIU / ml ) and advanced
hematogenous metastases . -
pubmed
Thirteen had pure
choriocarcinoma or
choriocarcinoma syndrome ( normal testes by palpation and ultrasound , normal serum
alpha - fetoprotein , advanced
hematogenous metastases and high level
hCG ) . -
pubmed
Hemoglobin , red blood cell count , hematocrit , serum
vitamin A , urinary
iodine and prevalence of
angular stomatitis were measured at baseline and at the end of the study after one year . -
pubmed
Polarization of natural killer T cells towards an NKT2 subpopulation occurs after stimulation with
alpha - galactosylceramide and
rhG - CSF in
aplastic anemia . -
pubmed
In summary , our results indicate that polarization of NKT cells towards the NKT2 subpopulation occurs after co - stimulation with
alpha - galactosylceramide and
rhG - CSF in
AA . -
pubmed
Inhibition of
Hsp90 activates
osteoclast c - Src signaling and promotes growth of
prostate carcinoma cells in bone . -
pubmed
Hsp90 inhibitors are being evaluated extensively in
patients with advanced
cancers . -
pubmed
However , the impact of
Hsp90 inhibition on signaling pathways in
normal tissues and the effect that this may have on the antitumor activity of these molecularly targeted drugs have not been rigorously examined . -
pubmed
Breast and prostate carcinomas are among those
cancers that respond to
Hsp90 inhibitors in animal xenograft models and in early studies in
patients . -
pubmed
Because these
cancers frequently metastasize to bone , it is important to determine the impact of
Hsp90 inhibitors in the bone environment . -
pubmed
prostate cancer xenografts , the
Hsp90 inhibitor
17 - AAG stimulates the intraosseous growth of
PC-3 M prostate carcinoma cells . -
pubmed
This activity is mediated not by a direct effect on the
tumor but by
Hsp90 - dependent stimulation of osteoclast maturation . -
pubmed
Both
kinases are key drivers of osteoclast maturation , and three agents that block osteoclastogenesis , the
Src inhibitor
dasatinib , the
bisphosphonate alendronate , and the osteoclast - specific apoptosis - inducer
reveromycin A , markedly reduced
17 - AAG - stimulated
tumor growth in bone . -
pubmed
These data emphasize the importance of understanding the complex role played by
Hsp90 in regulating signal transduction pathways in normal tissues as well as in
cancer cells , and they demonstrate that drug - dependent modulation of the local
tumor environment may profoundly affect the antitumor efficacy of
Hsp90 - directed therapy . -
pubmed
Hb targets : In all
patients with
CKD ,
Hb concentration should be & gt ; 11 g / dl and there is no evidence to justify total correction of
anemia on a routine basis . -
pubmed
Normalization of
Hb levels in
CKD is associated with an improvement in health - related quality of life , but without differences in mortality or the rate of
loss of kidney function ( Strength of Recommendation A ) . -
pubmed
Indications for
iron therapy :
Iron therapy is required in the large majority of
patients with
CKD treated with ESAs to achieve a
Hb equal to or greater than 11 g / dl ( Strength of Recommendation B ) . -
pubmed
The
Timothy syndrome mutation of cardiac
CaV1.2 ( L - type ) channels : multiple altered gating mechanisms and pharmacological restoration of inactivation . -
pubmed
Timothy syndrome (
TS ) is a
multiorgan dysfunction caused by a
Gly to
Arg substitution at position 406 ( G406R ) of the
human CaV1.2 ( L - type ) channel . -
pubmed
TNFalpha inhibits apoptotic cell clearance in the lung , exacerbating acute
inflammation . -
pubmed
Administration of
TNFalpha plus apoptotic cells during LPS - induced
lung injury augmented neutrophil accumulation and proinflammatory
cytokine production . -
pubmed
Experimental and clinical data implicate
calcium and
parathyroid hormone (
PTH ) in the development of
prostate cancer . -
pubmed
These findings support the hypothesis that serum
calcium and serum
PTH stimulate prostate growth in men without clinical
prostate cancer and have implications for the use of
PSA as a screening tool for
prostate cancer . -
pubmed
We compared the Access Genetics ( Minneapolis , MN ) polymerase chain reaction ( PCR ) assay ( AGPCR ) , DNA - DNA in situ hybridization ( ISH ; Ventana , Tucson , AZ ) , and
HPV-16 E7 PCR amplification in consecutively accessioned
oropharyngeal cancers . -
pubmed
Amphiregulin - dependent mucous cell metaplasia in a model of
nonallergic lung injury . -
pubmed
We have previously shown that
amphiregulin (
AREG ) , a ligand to the
epidermal growth factor receptor (
EGFR ) , is induced during the repair / differentiation process elicited by
naphthalene - induced
lung injury . -
pubmed
We show that
AREG and epithelial
EGFR expression is dispensable to pulmonary epithelial repair after
naphthalene - induced
lung injury , but regulates secretory cell differentiation to a mucus - producing phenotype . -
pubmed
We show that the pulmonary epithelium is the source of
AREG , suggesting that
naphthalene - induced
MCM is mediated through an autocrine signaling mechanism . -
pubmed
Our data demonstrate that
AREG - dependent
EGFR signaling in airway epithelial cells contributes to MCM in
naphthalene - induced
lung injury . -
pubmed
We conclude that
AREG may represent a determinant of
nonallergic chronic lung diseases complicated by
MCM . -
pubmed
Design of a
hypoxia - activated prodrug inhibitor of
O6 - alkylguanine - DNA alkyltransferase . -
pubmed
The efficacy of agents that alkylate the O-6 position of
guanine is inhibited by
O ( 6 )- alkylguanine - DNA alkyltransferase (
AGT ) which removes these lesions from the
tumor DNA . -
pubmed
To increase differential toxicity , inhibitors must selectively deplete
AGT in
tumors , while sparing normal tissues where this protein serves a protective function . -
pubmed
A newly synthesized prodrug of the
AGT inhibitor
O ( 6 )- benzylguanine (
O ( 6 )- BG ) with an
alpha , alpha - dimethyl-4 - nitrobenzyloxycarbonyl moiety masking the essential
2 - amino group has demonstrated the feasibility of targeting hypoxic regions that are unique to
solid tumors , for drug delivery . -
pubmed
Consistent with this design , 7 demonstrates both
hypoxia selective conversion by
EMT6 cells of 7 to 3 and hypoxic sensitization of
AGT containing
DU145 cells to the cytotoxic actions of
laromustine , while exhibiting improved solubility . -
pubmed
Here , we identified mutations in two functionally related genes (
DDHD1 and
CYP2U1 ) in individuals with autosomal - recessive forms of
HSP by using either the classical positional cloning or a combination of whole - genome linkage mapping and next - generation sequencing . -
pubmed
Interestingly , three subjects with
CYP2U1 mutations presented with a thin corpus callosum ,
white - matter abnormalities , and/or
calcification of the basal ganglia . -
pubmed
hASCs treatment also restored normal
inducible nitric oxide synthase expression in the spinal cord of
CCI animals . -
pubmed
Cadmium modulates
H - ras expression and
caspase-3 apoptotic cell death in
breast cancer epithelial
MCF-7 cells . -
pubmed
Given the
biotoxicity of
cadmium and its association with carcinogenesis , the effect of that metal ion (
Cd ( II ) ) was investigated , in a concentration - dependent fashion , on cell viability , cell proliferation ,
caspase-3 mediated apoptosis and
H - ras gene expression in
human breast cancer epithelial
MCF-7 cells transfected with the
H - ras oncogene ( wild type and G12V mutation ) . -
pubmed
Collectively , the results a ) indicate an interplay of cadmium with
H - ras(wt and G12V ) , with cadmium exhibiting a significant concentration - dependent effect on the modulation of
H - ras expression , cell viability and proliferation , and b ) project distinctly interwoven roles for both cadmium and
H - ras in aberrant physiologies in
cancer cells . -
pubmed
Additionally , through chromatin - immunoprecipitation with high - throughput - sequencing and transcriptional profiling , we identify
endothelin 2 (
Edn2 ) as an
NFIB target aberrantly activated in
NFIB - deficient hair follicle stem cells . -
pubmed
Consequently , the blood
calcium , calciotropic hormones , and skeleton are normal at birth despite severe
vitamin D deficiency or genetic deletion of
calcitriol or
vitamin D receptor . -
pubmed
Cytokines in
bipolar disorder vs. healthy control subjects : a systematic review and meta - analysis . -
pubmed
Our aim was to systematically review evidence of peripheral
cytokine alterations in
bipolar disorder integrating findings from various affective states . -
pubmed
METHODS : We conducted a meta - analysis of studies comparing peripheral
cytokine concentrations in
patients with
bipolar disorder with healthy control subjects . -
pubmed
Overall , concentrations of soluble
Interleukin ( IL )- 2 receptor (
sIL-2R ) ,
tumor necrosis factor - alpha (
TNF - alpha ) , soluble
tumor necrosis factor receptor type 1 (
sTNFR1 ) ( p & lt ; 0.001 each ) ,
sIL-6R ( p = 0.01 ) and
IL-4 ( p = 0.04 ) were significantly higher in
bipolar patients compared with healthy controls . -
pubmed
There were no significant differences between
bipolar disorder patients and healthy control subjects for
IL-1 ,
IL-2 ,
IL-5 ,
IL-6 ,
IL-8 ,
IL-10 ,
IL-12 ,
IL-1beta ,
IL-1 receptor antagonist (
IL-1RA ) ,
interferon - gamma (
IFN - gamma ) ,
transforming growth factor - beta1 (
TGF - beta1 ) and
sTNFR2 . -
pubmed
Activation of
M1 mAChRs by
lesatropane rescues
glutamate neurotoxicity in
PC12 cells via
PKC - mediated phosphorylation of
ERK1 / 2 . -
pubmed
Lesatropane , a synthesized chiral
tropane (
3S , 6S - isomer of satropane ) , is a novel
muscarinic agonist , and is being under preclinical development in China for the treatment of
primary glaucoma . -
pubmed
We found that
lesatropane could protect
PC12 cells from
glutamate - induced
neurotoxicity and reverse the decreased
ERK1 / 2 activation caused by
glutamate . -
pubmed
While
M1 mAChR is a therapeutic target of
Alzheimer ' s disease (
AD ) , the results of this paper contribute to further information concerning the activation of
M1 mAChR as a therapeutic target in
AD . -
pubmed
These data demonstrate for the first time that
palmitic acid can stimulate
IL-6 ,
TNF - alpha ,
IL-1 beta productions in HaCaT keratinocytes and cell proliferation , thereby potentially contributing to
acne inflammation and
pilosebaceous duct hyperkeratinization . -
pubmed
Effects of
green tea or
green tea extract on
insulin sensitivity and glycaemic control in populations at risk of
type 2 diabetes mellitus : a systematic review and meta - analysis of randomised controlled trials . -
pubmed
Therefore , we conducted a meta - analysis to evaluate the effect of
green tea or
green tea extract on
insulin sensitivity and glycaemic control in populations at risk of
type 2 diabetes mellitus (
T2DM ) . -
pubmed
There was no statistically significant difference between
green tea or
green tea extract group and placebo group with regard to fasting plasma
glucose [ standardised mean difference ( SMD ) 0.04 ; 95 % confidence interval ( CI ) -0.15 to 0.24 ] , fasting
serum insulin ( SMD -0.09 ; 95 % CI -0.30 to 0.11 ) , 2 - h plasma
glucose in the oral
glucose tolerance test ( OGTT-2 h ) ( SMD -0.14 ; 95 % CI -0.63 to 0.34 ) ,
haemoglobin A1c ( SMD 0.10 ; 95 % CI -0.13 to 0.33 ) and homeostasis model of
insulin resistance ( HOMA(IR ) ) index ( SMD -0.06 ; 95 % CI -0.35 to 0.23 ) in participants at risk of
T2DM . -
pubmed
CONCLUSIONS : The consumption of
green tea did not decrease the levels of fasting plasma
glucose , fasting serum
insulin ,
OGTT-2 h
glucose ,
haemoglobin A1c and HOMA(IR ) in populations at risk of
T2DM . -
pubmed
Larger , longer - term and high - quality RCTs are needed to further definitely determine the effect of
green tea or
green tea extract on
insulin sensitivity and glycaemic control in populations at risk of
T2DM . -
pubmed
In ovo administration of high dose
CORT significantly suppressed the growth rate from 3weeks of age and increased the frequency of
aggressive behaviors , and the dosage was associated with elevated plasma
CORT concentrations and significantly downregulated hypothalamic expression of
arginine vasotocin (
AVT ) and
corticotropin - releasing hormone ( CRH ) . -
pubmed
At the end of the study , the immunotoxicological effects of the GM
corn were evaluated through immunopathology parameters including body and organ weights , hematology and clinical chemistry parameters , histological examination , peripheral blood lymphocytes phenotype ; humoral immunity including antibody plaque - forming cell ,
serum immunoglobulin ,
cytokine and half hemolysis value ; cellular immunity such as mitogen - induced splenocyte proliferation ,
cytotoxic T - lymphocyte reaction ,
delayed - type hypersensitivity reaction ; non - specific immunity including phagocytic activities of phagocytes , natural killer cell activity . -
pubmed
CONCLUSION(S ): Variability during the menstrual cycle and correlations with reproductive hormone levels support a role of
cytokines in the menstrual cycle ; however , because of the limited variability for most
cytokines considered , the utility of urine as a matrix for assessment of
inflammation in menstrual cycle function appears limited for clinical purposes . -
pubmed
Clinicopathological characteristics and chronology of
p53 expression in the development of
gastric cancer . -
pubmed
BACKGROUND / AIMS : The present study was aimed to investigate the correlation between selected clinicopathological characteristics and
p53 protein overexpression , in Indian
gastric cancer patients . -
pubmed
The
p53 expression was analyzed in all the specimens by immunohistochemistry ( IHC ) and was correlated with the clinicopathological characteristics of the
patients as well as etiological factors for
gastric cancer . -
pubmed
The cases were considered
p53 overexpressed if more than 25 % of the
tumor cells were found to be expressing this protein . -
pubmed
CONCLUSIONS : Our observation showed that IHC - based detection of altered expression of
p53 protein in gastric
carcinomas may play an important role for diagnosing the progression of
gastric carcinoma , even in the early stages . -
pubmed
Urushiol Induces Apoptosis via a
p53 - dependent Pathway in
Human Gastric Cancer Cells . -
pubmed
METHODS : The
cytotoxicity of
urushiols was assessed by
MTT assays on the two
gastric adenocarcinoma cell lines ,
MKN-45 ( wild type of
p53 ) and
MKN-28 ( mutant type of
p53 ) . -
pubmed
Early changes of the kinetics of
monocyte trem-1 reflect final outcome in
human sepsis . -
pubmed
BACKGROUND :
TREM-1 (
triggering receptor expressed on myeloid cells ) , a receptor expressed on neutrophils and monocytes , is upregulated in
sepsis and seems to tune the inflammatory response . -
pubmed
RESULTS : Although surface
TREM-1 ,
sTREM-1 and
TREM-1 gene expression did not differ between
sepsis , severe
sepsis and
septic shock on day 1 , survivors had greater expression of surface
TREM-1 on days 3 and 7 compared to non - survivors . -
pubmed
A reciprocal decrease of the pro - inflammatory surface receptor
TREM-1 linked with
sepsis - induced immunosuppression may be part of the explanation . -
pubmed
BRD4 promotes
pancreatic ductal adenocarcinoma cell proliferation and enhances
gemcitabine resistance . -
pubmed
Our objective was to analyze the effect of
BRD4 on the cell progression and chemoresistance of
PDAC and the novel mechanisms involved . -
pubmed
In the present study , we firstly revealed that the expression of
BRD4 was significantly upregulated in
PDAC cell lines , compared to that in
human pancreatic duct epithelial cells . -
pubmed
An in vitro assay showed that the suppression of
BRD4 impaired
PDAC cell viability and proliferation . -
pubmed
Similarly , the
tumor growth rate was also decreased in vivo after silencing of
BRD4 . -
pubmed
In particular , we demonstrated that
BRD4 activated the
Sonic hedgehog (
Shh ) signaling pathway members in a ligand - independent manner in the
PDAC cells . -
pubmed
Together , our results indicate the important role of
BRD4 in
PDAC cell proliferation and chemoresistance and suggests that
BRD4 is a promising target directed against the transcriptional program of
PDAC . -
pubmed
Cranial CT ,
hematoma volume ,
hematoma enlargement ,
edema volume ,
serum matrix metalloproteinase-9 level were performed and compared between groups . -
pubmed
Cerebral edema amount and serum
MMP-9 level in the experimental group were significantly lower than control after 5 days and 14 days . -
pubmed
CONCLUSIONS : Ultra - early basal ganglia
intracerebral hemorrhage can remarkably reduce
hematoma enlargement ,
cerebral edema , serum
MMP-9 level , and improve the neurological function . -
pubmed
Although preclinical research in
murine models as well as clinical trials have provided ' proof of concept ' for
infection control by pre - emptive
CD8 T - cell immunotherapy , there exists no predictive model to experimentally evaluate parameters that determine antiviral efficacy of
human T cells in terms of virus control in functional organs , prevention of organ disease , and host survival benefit . -
pubmed
The
HCMV UL83 / pp65 - derived NLV - peptide was presented by transgenic
HLA - A2.1 in the context of a lethal
infection of
NOD / SCID / IL-2rg -/- mice with a chimeric murine
CMV ,
mCMV - NLV . -
pubmed
Nevertheless ,
SelT mutant
mice exhibited a
hyperactive behavior , suggesting that despite an apparent morphological compensation ,
SelT deficiency leads to
cerebral malfunction in adulthood . -
pubmed
Within the QTL SI regions , 44 genes were located , and
runt - related transcription factor 1 ,
dual - specificity tyrosine -( Y )- phosphorylation regulated kinase 1A (
DYRK1A ) , and
potassium inwardly - rectifying channel , subfamily J , member 15
KCNJ15 - which are reported to be related to the hematological traits and clinical features of
Down syndrome - were selected as positional candidate genes . -
pubmed
OBJECTIVE : To delineate the clinical features and potential mutation of the
ATP7A gene in a family affected with
Menkes disease . -
pubmed
Our study demonstrates the effectiveness of Linc00630 oligonucleotide - based promotion of
NSCLCs metastasis and proliferation , illuminating a new basis of
DDX23 -
Linc00630 -
HDAC1 signal axis for understanding its pathogenicity , which could be further developed as a valuable therapeutic strategy . -
pubmed
Identification of two novel
SH3PXD2B gene mutations in
Frank - Ter Haar syndrome by exome sequencing : Case report and review of the literature . -
pubmed
The most common underlying
genetic defect in
Frank - Ter Haar syndrome appears to be due to mutations in the
SH3PXD2B gene on chromosome 5q35.1 . -
pubmed
RESULTS : We report the first description of a Moroccan
FTHS patient with two novel compound heterozygous mutations c.806G>A ; p. Trp269 * ( maternal allele ) and c.892delC ; p. Asp299Thrfs*44 ( paternal allele ) in the
SH3PXD2B gene . -
pubmed
Epidemiological and genetic studies have identified elevated levels of
lipoprotein ( a ) ( (
Lp ( a ) ) as a causal and independent risk factor for
cardiovascular diseases (
CVD ) . -
pubmed
The
Lp ( a )-induced increased risk of
CVD may be mediated by both its proatherogenic and prothrombotic mechanisms . -
pubmed
Angiosarcoma treated successfully with anti -
PD-1 therapy - a case report . -
pubmed
Immunotherapy targeting either the
PD-1 receptor or
PD - L1 ligand has recently been shown to have activity in multiple
cancers including
melanoma , renal , and
non - small lung cancer . -
pubmed
His
tumor was found to express
PD - L1 and he received off - label pembrolizumab 2 mg / kg every 21 days for 13 cycles with marked shrinkage of his
liver disease and no new
facial lesions . -
pubmed
CONCLUSIONS : Although occasional responses to immunotherapy have been reported for
sarcomas , this case report demonstrates that
angiosarcoma can express
PD - L1 and have a sustained response to
PD-1 directed therapy . -
pubmed
The analysis of the current state of scientific knowledge about these pathologies shows that in the
Hutchinson - Gilford progeria and
Werner syndrome , the rate of brain aging is significantly lower than the rate of whole body aging , whereas in
Down syndrome , the brain ages faster than other organs due to
amyloid - beta accumulation and chronic oxidative stress in the brain tissue . -
pubmed
Mutational analysis of
ITPR1 in a Taiwanese cohort with
cerebellar ataxias . -
pubmed
Mutations in
ITPR1 have been implicated in
inherited cerebellar ataxias . -
pubmed
The aim of this study was to investigate the role of
ITPR1 mutations , including both large segmental deletion and single nucleotide mutations , in a Han Chinese cohort with
inherited cerebellar ataxias in Taiwan . -
pubmed
A novel
ITPR1 mutation , c.7721T>C ( p. V2574A ) , was identified in a family with
dominantly inherited cerebellar ataxia . -
pubmed
CONCLUSION :
ITPR1 mutation is an uncommon cause of
inherited cerebellar ataxia , accounting for 0.2 % ( 1/585 ) of patients with dominantly inherited
cerebellar ataxias in Taiwan . -
pubmed
This study broadens the mutational spectrum of
ITPR1 and also emphasizes the importance of considering
ITPR1 mutations as a potential cause of
inherited cerebellar ataxias . -
pubmed
Combination Immunotherapy of
MUC1 mRNA Nano - vaccine and
CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative
Breast Cancer . -
pubmed
In vivo studies demonstrated that the NP - based mRNA vaccine , targeted to
mannose receptors on DCs , could successfully express tumor antigen in the DCs of the lymph node ; that the NP vaccine could induce a strong , antigen - specific , in vivo cytotoxic T lymphocyte response against
TNBC 4T1 cells ; and that combination immunotherapy of the vaccine and anti -
CTLA-4 monoclonal antibody could significantly enhance anti -
tumor immune response compared to the vaccine or monoclonal antibody alone . -
pubmed
These data support both the NP as a carrier for delivery of mRNA vaccine and a potential combination immunotherapy of the NP - based mRNA vaccine and the
CTLA-4 inhibitor for
TNBC . -
pubmed
Acetylation of
alpha - tubulin at
Lys-40 is a potential biomarker for
cognitive deficits in various
neurological disorders . -
pubmed
This method has been successfully applied in a preclinical study of
organophosphate neurotoxicity , and we found that chronic exposure to
chlorpyrifos led to a significant and persistent inhibition of brain
tubulin acetylation . -
pubmed
miR372 Promotes Progression of
Liver Cancer Cells by Upregulating
erbB-2 through Enhancement of
YB-1 . -
pubmed
Our observations suggest that miR372 promotes
liver cancer cell cycle progress by activating
cyclin - dependent kinase 2 (
CDK2)-
cyclin E -
P21 /
Cip1 complex through miR372 -
YB-1 -
beta - catenin -
LEF /
TCF4 -
PKM2 -
erbB-2 axis . -
pubmed
Anaplastic lymphoma kinase - negative uterine inflammatory myofibroblastic tumor containing the
ETV6 -
NTRK3 fusion gene : a case report . -
pubmed
Approximately 50 % of
IMT patients have
anaplastic lymphoma kinase gene (
ALK ) rearrangements . -
pubmed
Recent studies described novel fusions involving
ROS1 ,
platelet - derived growth factor receptor beta (
PDGFR - beta ) , and
ETS translocation variant (
ETV6 ) genes in a subset of
ALK - negative patients . -
pubmed
This association of an
ETV6 -
NTRK3 fusion oncogene with an
ALK - negative
uterine IMT increases our understanding of this
neoplasm , which may help the development of specific therapies . -
pubmed
Clinical and Echocardiographic Impact of
Tafazzin Variants on
Dilated Cardiomyopathy Phenotype in Left Ventricular Non - Compaction Patients in Early Infancy . -
pubmed
Variants in the gene encoding
tafazzin (
TAZ ) may change mitochondrial function and cause dysfunction of many organs , but they also contribute to the
DCM phenotype in
LVNC , and the clinical and echocardiographic features of children with this phenotype are poorly understood . -
pubmed
The patients with
TAZ variants had a higher frequency of early onset of disease ( 92.3 % vs. 62.3 % , P=0.0182 ) ,
positive family history ( 73.3 % vs. 20.8 % , P=0.0001 ) , and higher LV posterior wall thickness Z - score ( 8.55 + -2.60 vs. 5.81 + -2.56 , P=0.0103 ) than those without
TAZ variants , although the mortality of both groups was similar . -
pubmed
CONCLUSIONS : This study provides new insight into the impact of
DCM phenotype
LVNC and emphasizes the clinical advantages available for
LVNC patients with
TAZ variants . -
pubmed
Prostate - specific membrane antigen (
PSMA ) is a membrane glycoprotein that is overexpressed in
prostate cancer cells . -
pubmed
Many studies have reported that upregulation of
SHP2 expression is closely related to
human cancer , such as
breast cancer ,
liver cancer and
gastric cancer . -
pubmed
Hence ,
SHP2 has become a promising target for
cancer immunotherapy . -
pubmed
TWIK - related spinal cord K + channel (
TRESK ) is a K2P channel with a particularly enriched role in sensory neurons and in vivo
pain pathways . -
pubmed
Autoimmune - Mediated
Retinopathy in
CXCR5 - Deficient
Mice as the Result of Age - Related
Macular Degeneration Associated Proteins Accumulation . -
pubmed
Previous research has shown that
CXCR5-/-
mice develop
retinal degeneration (
RD ) with age , a characteristic related to
age macular degeneration (
AMD ) . -
pubmed
RD in these
mice is not well - understood , and in this study , we sought to characterize further the
RD phenotype and to gain mechanistic insights into the function of
CXCR5 in the retina . -
pubmed
These results indicate that with age ,
CXCR5-/-
mice develop
RD characterized by
microglia dysfunction , increased production of
CXCL13 in the RPE progressive photoreceptor ,
neuronal loss , and sub - RPE deposition of cellular debris , resulting in the production of immunogenic proteins and autoimmune - mediated
RD . -
pubmed
Our present results underline the potential use of
cagE genotyping in the risk assessment of the development of
periodontal attachment loss in Swedish adolescents . -
pubmed
ER - mediated anti - tumor effects of
shikonin on
breast cancer . -
pubmed
Estrogen receptor (
ER ) is expressed in most
Breast cancer (
BC )
patients . -
pubmed
G protein - coupled estrogen receptor (
GPER ) , which is a membrane - bound
estrogen receptor , is associated with the
tumor development and progression in
BC . -
pubmed
This study aims to assess the effects of
shikonin on the cell proliferation , cell cycle and cell apoptosis of
BC and whether the effects are related to
ER /
GPER signaling pathway . -
pubmed
CAMTA-1 Expression in 24 Cases of
Hepatic Epithelioid Hemangioendothelioma in a Single Institute : Diagnostic Utility for Differential Diagnosis from
Hepatic Angiosarcoma . -
pubmed
EHEs are known to have the
WWTR1 -
CAMTA1 fusion gene , and nuclear expression of
CAMTA1 by immunohistochemistry ( IHC ) has been reported in about 90 % of
EHEs in multiple organs . -
pubmed
Our study aimed to validate the diagnostic utility of
CAMTA1 expression in
EHEs , especially in the liver . -
pubmed
PATIENTS AND METHODS : IHC was performed using anti -
CAMTA1 antibody in 34
tumors ( 24
hepatic EHEs and 10
angiosarcomas ) . -
pubmed
In
CAMTA1 - negative
EHEs ,
TFE3 IHC was performed . -
pubmed
RESULTS : Of the 24
hepatic EHEs , 22 ( 91.6 % ) showed nuclear staining for
CAMTA1 . -
pubmed
One of two
CAMTA1 - negative cases showed
TFE3 positivity . -
pubmed
Meanwhile , all 10
angiosarcoma cases had no
CAMTA1 expression . -
pubmed
CONCLUSION :
CAMTA1 is a highly sensitive and specific marker for diagnosis of
hepatic EHE . -
pubmed
Arginase-1 - based vaccination against the
tumor microenvironment : the identification of an optimal T - cell epitope . -
pubmed
L - arginine depletion by regulatory cells and
cancer cells expressing
arginase-1 (
Arg-1 ) is a vital contributor to the immunosuppressive tumor microenvironment in
patients with
cancer . -
pubmed
Because
Arg-1 plays an important role in the immunosuppressive microenvironment in most
cancers , an immune modulatory vaccination approach can readily be employed to tilt the balance away from immune suppression in these settings . -
pubmed
Albumin - stabilized
manganese - based nanocomposites with sensitive
tumor microenvironment responsivity and their application for efficient SiRNA delivery in
brain tumors . -
pubmed
Background : Pretreatment
albumin /
alkaline phosphatase ratio ( AAPR ) has been discussed about its prognostic value in several
malignancies , whereas its role in
cervical cancer remains unclear . -
pubmed
Background
Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy , caused by
NOTCH3 mutations , is characterized by recurrent
ischemic strokes and progressive
cognitive decline . -
pubmed
Inhibitors of
Bruton ' s tyrosine kinase (
BTK ) have established therapeutic activity in
patients with
Waldenstrom macroglobulinemia (
WM ) . -
pubmed
Zanubrutinib , a potent and selective
BTK inhibitor , was evaluated in a phase 1/2 study in
patients with
WM who were either treatment - naive ( TN ) or had relapsed / refractory (
R / R ) disease . -
pubmed
Pathological features , immunoprofile and
mismatch repair protein expression status in
uterine endometrioid carcinoma : focus on MELF pattern of myoinvasion . -
pubmed
Our data showed a higher frequency of immunohistochemical
MLH1 -
PMS2 loss in MELF- pattern of invasion ( 32.67 % of MELF- cases vs 21.43 % of MELF + cases ) but a higher prevalence of
MSH2 -
MSH6 loss in MELF + pattern ( 7.14 % in
MELF + population vs 3.96 % of MELF- population ) CONCLUSIONS : The morphological recognition of MELF pattern is more reliable than immunohistochemical and molecular signatures of EEC in predicting the risk of nodal involvement . -
pubmed
Compared with severe and moderate
patients ,
lymphocytopenia occurred in 85.71 % critically ill
patients , and serum
IL-2R ,
IL-6 ,
IL-8 ,
TNF - alpha ,
LDH , and
cTnI were also increased in 71.42 % , 83.33 % , 57.14 % , 71.43 % , 100 % and 42.86 % in critically ill
patients . -
pubmed
Conclusion : We found some clinical characteristic and inflammatory
cytokines could reveal the severity of
COVID-19 during the outbreak phage . -
pubmed
Deletions in
BCP - ALL result in a TAD more
FLT3 . -
pubmed
A novel mutation in the
RS1 gene in a Chinese family with
X - linked congenital retinoschisis . -
pubmed
To conclude , the present study discovered a novel
XLRS mutation in a Chinese family , where the Trp122 * mutation caused a significant change in the function of the
RS1 protein . -
pubmed
Possible involvement of
neuropeptide and neurotransmitter receptors in
Adenomyosis . -
pubmed
BACKGROUND : Accumulating data indicate that sensory nerve derived neuropeptides such as
substance P and
calcitonin gene related - protein (
CGRP ) can accelerate the progression of
endometriosis via their respective receptors , so can agonists to their respective
receptors receptor 1 (
NK1R ) ,
receptor activity modifying protein 1 (
RAMP-1 ) and
calcitonin receptor - like receptor (
CRLR ) . -
pubmed
In contrast ,
women with
endometriosis appear to have depressed vagal activity , concordant with reduced expression of
alpha7 nicotinic acetylcholine receptor (
alpha7nAChR ) . -
pubmed
METHODS : Adenomyotic tissue samples from 30
women with
adenomyosis and control endometrial tissue samples from 24
women without
adenomyosis were collected and subjected to immunohistochemistry analysis of
RAMP1 ,
CRLR ,
NK1R ,
ADRB2 and
alpha7nAChR , along with their demographic and clinical information . -
pubmed
RESULTS : We found that the staining levels of
NK1R ,
CRLR ,
RAMP1 and
ADRB2 were all significantly elevated in
adenomyotic lesions as compared with control endometrium . -
pubmed
The severity of
dysmenorrhea correlated positively with lesional
ADRB2 staining levels . -
pubmed
CONCLUSIONS : Our results suggest that
SP ,
CGRP and
noradrenaline may promote , while
acetylcholine may stall , the progression of
adenomyosis through their respective receptors on
adenomyotic lesions . -
pubmed
Additionally , through the activation of the hypothalamic - pituitary - adrenal ( HPA)-sympatho - adrenal - medullary ( SAM ) axes and the lesional overexpression of
ADRB2 ,
adenomyosis - associated
dysmenorrhea and
adenomyotic lesions may be mutually promotional , forming a viscous feed - forward cycle . -
pubmed
Relative rates of
cholesterol and
bile acid synthesis were estimated in
patients with
cholesterol gallstones and
biliary obstruction by determining the hepatic activities of
3 - hydroxy-3 - methylglutaryl - CoA reductase and
cholesterol 7 alpha - hydroxylase , the respective rate - determining enzymes for
cholesterol and
bile acid synthesis . -
pubmed
As compared with eight control studies ,
3 - hydroxy-3 - methylglutaryl - CoA reductase activity was 27 % higher in 12
gallstone subjects , but 75 % lower in 5
subjects with
biliary obstruction . -
pubmed
Cholesterol 7 alpha - hydroxylase activity was reduced in the
gallstone ( 47 % lower ) and
biliary obstruction ( 78 % lower ) subjects . -
pubmed
Patterns of
keratin 19 expression in normal , metaplastic , condylomatous , atrophic ,
dysplastic , and malignant cervical squamous epithelium . -
pubmed
Keratin 19 (
K-19 ) expression has been strongly correlated with
dysplasia in oral epithelium . -
pubmed
Expression of
K-19 was evaluated by immunoperoxidase staining in
formalin - fixed
normal ectocervical tissue ,
normal endocervical tissue ,
cervical dysplasia ,
squamous metaplasia ,
atrophic epithelium ,
cervical condylomas , and invasive
carcinoma to determine if a correlation of
K-19 expression with
dysplasia was present in the cervical epithelium . -
pubmed
Uniform expression of
K-19 was seen in endocervical epithelium and in the basal layer of
normal ectocervical epithelium in all areas where these epithelia were present . -
pubmed
Cervical dysplasia without associated condylomatous changes showed increased expression of
K-19 in suprabasal epithelium , corresponding to the level of immature cells . -
pubmed
There was considerable overlap in the patterns of
K-19 expression in
dysplastic and metaplastic epithelium . -
pubmed
Thus
K-19 staining pattern could not be used as a distinctive marker for
dysplasia in the cervical epithelium . -
pubmed
Atrophic epithelium showed a characteristic uniform but low - level expression of
K-19 in suprabasal areas . -
pubmed
Condylomas showed focal loss of
K-19 in the basal layer , suggesting induction of premature differentiation in the basal layer by
human papillomavirus infection . -
pubmed
In
patients with unilateral surgery , 20 of 22
patients exhibited comfortable postoperative courses , and in
patients with bilateral surgery , eight of 10
patients had less conjunctival injection ,
chemosis , corneal staining , or
lid edema on the side with the
collagen shield . -
pubmed
Several treatments from the latter category , namely ,
hypertensive ,
hypervolemic hemodilutional therapy and the
calcium channel blocker
nimodipine , have proven moderately effective and are in widespread clinical use . -
pubmed
Cancer cells were equally stained with fluorescent
R 1881 and
mibolerone , and this fluorescence seems to be made up of both the
androgen receptor and
progestin - binding protein . -
pubmed
Hereditary dysfibrinogenaemia (
fibrinogen Jena)--report of a family study . -
pubmed
Both
IgG and
IgM antibody activities of
lepromatous leprosy ( L - lep ) sera to 33 KD protein are heterogeneous and directed to more than 4 epitopes . -
pubmed
The potential use of these
McAbs in studying the pathomechanism of
leprosy are currently being investigated . -
pubmed
Although a causative contribution of endogenous
ANF in the natriuretic response to acute
hypervolemia is well established , its participation in the maintenance of salt balance during large variations in dietary
Na intake is less certain . -
pubmed
Although
hypotension in vivo generally requires natriuretic doses of
ANF , this may be due to compensatory reflexes in the intact animal. -
pubmed
[ The possibilities of the use of exogenous
TSH in the treatment of
thyroid cancer metastases ] . -
pubmed
Peripheral blood from 21 non - institutionalized
children with
Down ' s syndrome (
DS ) and 21 age and sex matched simultaneously studied healthy controls , was analysed for
monoclonal antibody defined T cells and T cell subsets , using a fluorescence activated cell sorter , and the autologous ( AMLR ) and allogeneic mixed lymphocyte reaction ( MLR ) . -
pubmed
Bilateral inferior petrosal sinus
corticotropin sampling with
corticotropin - releasing hormone stimulation in a pregnant
patient with
Cushing ' s syndrome . -
pubmed
Bilateral simultaneous inferior petrosal sinus
corticotropin sampling with
corticotropin - releasing hormone stimulation was performed before transphenoidal pituitary adenomectomy , with successful localization of the
pituitary adenoma . -
pubmed
Thymidine phosphorylase expression in
Kaposi sarcoma . -
pubmed
AIMS : To examine the immunohistochemical distribution of
thymidine phosphorylase (
TP ) in all clinicopathological subtypes of
Kaposi sarcoma . -
pubmed
CONCLUSIONS : The strong immunoexpression of
TP suggests up - regulation of
TP and a role for
TP in angiogensis in
Kaposi sarcoma . -
pubmed
The differential staining of the various cell components of
Kaposi sarcoma also suggest that
TP either plays a role in the differentiation and maturation of
Kaposi sarcoma or is a reflection of such changes . -
pubmed
DATA SOURCES : Intervention studies cited in the Medline database from January 1976 until January 1995 , with index terms
cholesterol ,
hypercholesterolaemia ,
hyperlipidaemia , thyrotrophin (
TSH ) ,
hypothyroidism , thyroid and
human . -
pubmed
Thyroid substitution therapy in
patients with
subclinical hypothyroidism , restoring the
TSH levels to normal , decreased total
cholesterol by 0.4 mmol / l ( 95 % confidence interval ( Cl ) 0.2 - 0.6 mmol / l ) independently of the initial plasma level . -
pubmed
The effect of thyroid substitution therapy on
HDL - cholesterol in
patients with
subclinical hypothyroidism was not consistent . -
pubmed
Previous studies have demonstrated the presence in
psoriatic lesions of ultrastructural and molecular alterations of the basement membrane and an altered polarized distribution of the
integrins ; this latter alteration has also been observed in uninvolved skin . -
pubmed
Immunohistochemical
metallothionein expression in
thymoma : correlation with histological types and cellular origin . -
pubmed
Since the histopathological types of
thymoma have unpredictable invasive potential ,
MT over - expression was investigated as a possible marker of the invasive potential of
thymomas . -
pubmed
We studied immunohistochemical
MT expression in 27
non - invasive thymomas , 20
micro - invasive thymomas , and 23
macro - invasive thymomas with a
mouse monoclonal anti - MT antibody E9 on
formalin - fixed paraffin - embedded tissues . -
pubmed
MT expression was significantly different among the three groups of
thymomas ( P = 0.02 ) with a stronger expression in invasive
thymomas ( P = 0.003 ) . -
pubmed
However ,
MT expression was not exclusively limited to invasive
thymomas . -
pubmed
Analysis of
MT expression according to the histological types of the
thymomas revealed that eight of nine
spindle cell thymomas , none of 10 small polygonal cell
thymomas , four of 14 mixed
thymomas , seven of 29 large polygonal cell
thymomas , and seven of eight
squamoid thymomas significantly expressed
MT . -
pubmed
There was a statistically significant difference in
MT expression among different histological types of
thymomas ( P = 0.000 ) . -
pubmed
Since
spindle cell thymoma was usually non - invasive and squamoid
thymoma was more aggressive ,
MT expression does not correlate with the invasive potential of different histological types of
thymomas . -
pubmed
But because medullary epithelial cells of the thymus were positive for
MT , our results suggest that both
spindle cell thymoma and
squamoid thymoma might derive from the medullary compartment of the thymus . -
pubmed
The functional activity of each LCR was measured by cloning it into a
luciferase expression vector , followed by transfection into both normal oral keratinocytes and
oral cancer cells . -
pubmed
Near nerve local
insulin prevents conduction slowing in experimental
diabetes . -
pubmed
We tested the hypothesis that
insulin itself influences conduction of myelinated fibers independent of
hyperglycemia in experimental
diabetes . -
pubmed
Low dose intermittent ( 0.2 units thrice weekly ) Toronto ( regular )
insulin was injected at the sciatic notch and knee near the left sciatic nerve of
rats rendered
diabetic with
citrate buffered
streptozotocin or nondiabetic
rats given
citrate only . -
pubmed
The
diabetic rats developed
hyperglycemia , elevated glycosylated
hemoglobin levels and had slowing of right ( saline treated ) sciatic tibial motor and caudal sensory conduction velocity . -
pubmed
In nondiabetic
rats , conduction velocities were slightly higher on the
insulin treated side , but the influence of
insulin was less robust than in
diabetics . -
pubmed
The
insulin treated sural branches of the sciatic nerves in
diabetics had a higher percentage of small ( & lt ; or = 9.0 microm diameter ) myelinated fibers than the saline treated nerves . -
pubmed
Local
insulin has a trophic influence on myelinated fibers that is prominent in
diabetic nerves and is independent of
hyperglycemia . -
pubmed
Cilostamide had no effect on the
cAMP content stimulated by
PTH or
AVP in PCTs and
MCDs . -
pubmed
These results indicate that
PDE activities were unevenly distributed along the
rat nephron and
cAMP - PDE was composed of at least three isoforms , namely type I , III and IV in PCTs and
MCDs . -
pubmed
Among these ,
type - IV PDE was responsible for hydrolysis of
cAMP in PCTs , and
type - I and IV PDE were responsible for that in
MCDs . -
pubmed
Polymorphism in the promoter region of the
alpha 2A adrenergic receptor gene and
mood disorders . -
pubmed
Alpha 2 adrenergic receptors are thought to play a crucial role in the etiology or treatment of
mood disorders . -
pubmed
Polymorphism(s ) in the promoter region of the
alpha 2 receptor may affect the gene expression and be associated with
mood disorders . -
pubmed
We studied the previously reported polymorphisms of the
alpha 2A receptor gene at position-1291 in 114 healthy controls and 103
mood disorder patients . -
pubmed
Our results suggest there is no association between this polymorphism in the promoter region of the
alpha 2A receptor gene and
mood disorders . -
pubmed
A number of proto - oncogenes (
Cyclin D and
PTHLH ) as well as putative
tumor suppressor genes are localized on 12p ; however , their role in pathogenesis and prognosis of
testicular germ cell tumors has not been defined yet . -
pubmed
The
startle disease mutation Q266H , in the second transmembrane domain of the
human glycine receptor , impairs channel gating . -
pubmed
Hyperekplexia (
startle disease ) results from mutations in the
glycine receptor chloride channel that disrupt inhibitory synaptic transmission . -
pubmed
Both
vWF antigen and
platelet aggregation decreased 2 weeks after the onset of
myocardial infarction . -
pubmed
CONCLUSIONS : Shear - induced
platelet aggregation is enhanced in plasma in the presence of acute
myocardial infarction , apparently as a result of increased
vWF concentration . -
pubmed
We measured the serum levels of
IL-7 before and after bone marrow transplant ( BMT ) in 32
children undergoing BMT for
genetic diseases (
severe combined immune deficiency (
SCID ) and
thalassemia ) ,
aplastic anemia , and
acute lymphoblastic and non - lymphoblastic leukemia (
ALL and
ANLL ) . -
pubmed
Prior to BMT , the highest
IL-7 levels were observed in
patients with
SCID and
ALL , i.e. -
pubmed
Patients with
thalassemia and
ANLL had normal levels of
IL-7 . -
pubmed
Over the 8 weeks following BMT , the
IL-7 levels of
patients with
SCID and
ALL fell as the absolute lymphocyte count ( ALC ) increased . -
pubmed
No detectable change in
IL-7 levels was observed in the
patients with
thalassemia and
ANLL . -
pubmed
Levels of
IL-7 were highest in the young
infants with
SCID compared to the age - matched controls . -
pubmed
Together , the data demonstrate that serum levels of
IL-7 in
lymphopenic patients are inversely related to
patient age and the absolute lymphocyte count ( ALC ) . -
pubmed
BACKGROUND : We have previously developed a mu - capture - based radioimmunoassay ( RIA ) for detecting virus - specific
IgM for the diagnosis of
poliomyelitis . -
pubmed
CONCLUSION : Cross - reactive epitopes between
poliovirus serotypes and between
polioviruses and other enteroviruses may compromise the use of an assay for virus - specific
IgM for
poliovirus diagnosis . -
pubmed
In this review we discuss the role of two of these neuropeptides ,
somatostatin and
substance P , with regard to their receptor expression in the
human immune system and their role in the diagnosis and treatment of
immune - mediated diseases . -
pubmed
Alosetron , a
5 - HT3 receptor antagonist , delays colonic transit in
patients with
irritable bowel syndrome and healthy
volunteers . -
pubmed
BACKGROUND :
Alosetron is a potent and selective
5 - HT3 receptor antagonist , which has been shown to be beneficial in the treatment of female
patients with
non - constipated irritable bowel syndrome . -
pubmed
Haplotype analysis suggests that this
FSGS gene is located in a 19 - cM region flanked by D1S416 and D1S413 , of which 6 cM overlaps with
SRN1 , suggesting that these distinct clinical subsets of
kidney disease may be allelic . -
pubmed
Phase I pilot trial of the bispecific antibody MDXH210 ( anti -
Fc gamma RI X anti -
HER-2 / neu ) in
patients whose
prostate cancer overexpresses
HER-2 / neu . -
pubmed
The goal of this study was to evaluate , in
patients with
prostate cancer , the toxicity profile and biologic activity of the bispecific antibody MDXH210 , which has specificity for the non - ligand - binding site of the high - affinity
immunoglobulin G receptor (
Fc gamma RI ) and the extracellular domain of the
HER-2 /
neu proto - oncogene product . -
pubmed
Patients with
prostate cancer that expressed
HER-2 / neu were entered into a phase I dose - escalation trial of
MDXH210 . -
pubmed
MDXH210 can be given safely to
patients with
HER-2 / neu - positive
prostate cancer in doses of at least 8 mg / m2 . -
pubmed
Hypertrophic pulmonary osteoarthropathy associated with
non - small cell lung cancer demonstrated
growth hormone - releasing hormone by immunohistochemical analysis . -
pubmed
Hypertrophic pulmonary osteoarthropathy (
HPO ) associated with
non - small cell lung cancer in a 58 - year - old
man was accompanied by an elevated serum level of
growth hormone (
GH ) . -
pubmed
HPO rapidly disappeared after resection of the primary
tumor and the elevation of
serum GH was resolved . -
pubmed
Immunohistochemically the
tumor contained
growth hormone - releasing hormone (
GHRH ) but not
GH . -
pubmed
These findings suggest that the high
serum GH level due to ectopic
GHRH production in the
tumor , was a contributing factor in
HPO . -
pubmed
This is the second reported case of
non - small cell lung cancer which was immunohistochemically positive for
GHRH associated with
HPO . -
pubmed
We now show that DNA damage is able to induce senescence in
tumor cells expressing wild - type
p53 . -
pubmed
Pemphigus vulgaris in Jewish patients is associated with
HLA - A region genes : mapping by microsatellite markers . -
pubmed
Pemphigus vulgaris (
PV ) is the most severe
autoimmune blistering disorder of the skin that is mediated by circulating autoantibodies against
desmoglein 3 (
Dsg3 ) . -
pubmed
It has been reported that in Jews the associated haplotype in
PV is
human leukocyte antigen (
HLA ) B38 ,
DRB1 * 0402 ,
DQB1 * 0302 . -
pubmed
Dsg3 - specific T - cell responses were detected in
PV patients but also in healthy individuals who were either carriers of the PV - associated DRB1 * 0402 allele or alleles that share similar or identical peptide binding motifs to
DRB1 * 0402 . -
pubmed
However , four probes , D6S265 , C_527 , D6S510 , and MOGC , which are all mapped to the region of
HLA - A , were highly associated with
PV . -
pubmed
[ Correction in vitro of A and B
hemophilia by various dilutions of normal blood : modifications of clotting time and of
prothrombin consumption ] . -
pubmed
Using a
squamous carcinoma cell line we show that endogenous accumulation of GM3 disrupts the ligand - independent association of the
integrin beta1 subunit with
EGFR and results in inhibition of cell proliferation . -
pubmed
Tissue and plasma expression of the angiogenic peptide
adrenomedullin in
breast cancer . -
pubmed
Adrenomedullin (
ADM ) is an angiogenic factor that has also been shown to be a mitogen and a
hypoxia survival factor for
tumour cells . -
pubmed
These properties point to
ADM as a potential promoter of
human malignancies , but little data are available concerning the expression of
ADM in
human breast cancer . -
pubmed
In the present work , we have examined
ADM peptide expression in a series of malignant
breast tumours by immunohistochemistry using a newly developed anti -
ADM monoclonal antibody . -
pubmed
ADM - peptide expression in
breast tumours was significantly correlated with axillary lymph node metastasis ( P=0.030 ) . -
pubmed
Analysis of
ADM plasma concentrations showed no significant difference between the circulating
ADM levels of
breast cancer patients and healthy controls . -
pubmed
However , a significant positive correlation was found between
tumour size and plasma
ADM levels ( r=0.641 , P=0.017 ) . -
pubmed
Moreover ,
ADM levels in
breast cancer patients correlated with the presence of lymph node metastasis ( P=0.002 ) . -
pubmed
In conclusion , we have shown for the first time that
ADM peptide is widely expressed in
breast cancer and that the degree of expression is associated with lymph node metastasis . -
pubmed
ADM peptide in plasma of
breast cancer patients reflects the size of the primary
tumour , but is unlikely to be a useful tumour marker for the detection of
breast cancer . -
pubmed
Temporal relationship of
muscle weakness and
pain reduction in subjects treated with
botulinum toxin A. -
pubmed
We show here that , in the
Pitx3 - deficient
aphakia ( ak )
mouse mutant , the mesDA system is malformed . -
pubmed
Factor VIII levels and the risk of
pre - eclampsia ,
HELLP syndrome , pregnancy related
hypertension and severe
intrauterine growth retardation . -
pubmed
The aim of this study was to determine whether elevated
factor VIII levels are associated with
uteroplacental insufficiency , in particular
pre - eclampsia ,
HELLP syndrome or pregnancy - induced
hypertension and
intrauterine growth retardation . -
pubmed
METHODS : Plasma samples of 75
women with a history of pregnancy complicated by
pre - eclampsia ,
HELLP syndrome , pregnancy induced
hypertension or
intrauterine growth restriction were tested for
factor VIII : C (
FVIII : C ) levels at a minimum of 10 weeks post - partum . -
pubmed
In a logistic regression model , after adjusting for age and blood group , no effect of
factor VIII : C levels on the risk of pregnancy complications was observed , with the exception of
IUGR with ( OR 2.9 , CI 1.0 - 8.7 ) or without
hypertension ( OR 2.0 , CI 0.7 - 6.4 ) . -
pubmed
While no such effect could be shown a causal relationship between elevated levels of
factor VIII and conditions of
uteroplacental insufficiency such as
pre - eclampsia ,
HELLP syndrome , pregnancy - induced
hypertension and
IUGR is not very likely . -
pubmed
Protein kinase C - dependent regulation of
NAG-1 /
placental bone morphogenic protein /
MIC-1 expression in
LNCaP prostate carcinoma cells . -
pubmed
NAG-1 ( nonsteroidal anti - inflammatory drug - activated gene ) , a member of the
transforming growth factor beta superfamily , is involved in cellular processes such as
inflammation , apoptosis / survival , and tumorigenesis and is regulated by
p53 ,
Sp1 , and
Egr-1 . -
pubmed
In the current study , the regulation of
NAG-1 expression in
LNCaP human prostate carcinoma cells by
12 - O - tetradecanoylphorbol-13 - acetate (
TPA ) was examined . -
pubmed
Deletion of the second orf did not abrogate
hemolysis , indicating that the first ORF encoded the
hemolysin . -
pubmed
Mucosal immunization of
sheep with a
Maedi - Visna virus (
MVV )
env DNA vaccine protects against early
MVV productive infection . -
pubmed
Gene gun mucosal DNA immunization of
sheep with a plasmid expressing the
env gene of
Maedi - Visna virus (
MVV ) was used to examine the protection against
MVV infection in
sheep from a naturally infected flock . -
pubmed
BACKGROUND : The importance of achieving a
low - density lipoprotein cholesterol (
LDL - C ) level less than 100 mg / dL in
patients with
coronary artery disease (
CAD ) or
cerebrovascular disease (
CVD ) is well established . -
pubmed
Relationship between renal function and plasma
brain natriuretic peptide in
patients with
heart failure . -
pubmed
OBJECTIVES : This study sought to evaluate the relationship between
brain natriuretic peptide (
BNP ) , renal function , and the severity of
congestive heart failure (
CHF ) . -
pubmed
BACKGROUND : Both
BNP and renal function are prognostic predictors in
CHF patients . -
pubmed
METHODS : We measured the plasma
BNP level in the aortic root and coronary sinus in 366 consecutive
patients with
CHF . -
pubmed
CONCLUSIONS : These findings suggest that decreased clearance from the kidney contributes to the elevated
BNP in
CHF patients with
renal dysfunction , especially in
patients with an eGFR & lt;60 ml / min . -
pubmed
The methodology is illustrated through an example based on a study about the joint effects of
XRCC1 polymorphisms and smoking on
bladder cancer . -
pubmed
Low
meprin alpha expression differentiates primary
ovarian mucinous carcinoma from
gastrointestinal cancers that commonly metastasise to the ovaries . -
pubmed
AIM : To investigate the expression of two intestinal markers ,
galectin 4 and
meprin alpha , in
mucinous carcinomas of the ovary and gastrointestinal tract . -
pubmed
METHODS : Using immunohistochemical analysis , the expression of
galectin 4 and
meprin alpha was investigated in 10
MOCs and in 38 mucinous
adenocarcinomas of colon , pancreas , stomach and appendix , the most common sites of origin of ovarian metastases . -
pubmed
RESULTS : Total cytoplasmic
galectin 4 expression was relatively consistent between the different
carcinomas . -
pubmed
Membranous
meprin alpha expression was significantly lower in
MOCs compared with gastrointestinal
carcinomas . -
pubmed
Moreover ,
meprin alpha expression showed greater discrimination between the ovarian and gastrointestinal
carcinomas than the
cytokeratins CK7 and
CK20 , the current standard immunohistochemical markers used to determine the tissue origin of
mucinous carcinomas involving the ovaries . -
pubmed
CONCLUSIONS :
Meprin alpha is a useful additional marker in differentiating primary from secondary
mucinous adenocarcinomas of the ovary . -
pubmed
OBJECTIVE : We examined factors associated with screening for
albuminuria and initiation of
ACE inhibitor or
angiotensin receptor blocker ( ARB ) treatment in diabetic
patients . -
pubmed
Patients & gt ; or = 65 years of age , those with higher
HbA ( 1c ) , those with
cardiovascular disease (
CVD ) , and those without
hyperlipidemia were less likely to be screened . -
pubmed
Initiation of therapy was associated with positive screening test results , BMI & gt ; or = 25 kg / m(2 ) , treatment with
insulin or oral antidiabetic agents ,
peripheral neuropathy , systolic blood pressure & gt ; or = 140 mmHg , and
CVD . -
pubmed
pneumophila
cytochrome c maturation locus in low -
iron growth ,
intracellular infection , and virulence . -
pubmed
STUDY DESIGN : Retrospective observational analysis of claims - based data of health plan members with
CAD receiving 1 or more prescriptions per year of any of the following classes of medications used for secondary prevention of
CAD : lipid - lowering agents ,
angiotensin - converting enzyme ( ACE ) inhibitors , or
angiotensin receptor blockers ( ARBs ) and beta - blockers . -
pubmed
Expression of
cyclooxygenase-2 in
osteosarcoma of bone . -
pubmed
Several studies indicate that
cyclooxygenase-2 (
COX-2 ) is overexpressed in
human malignancies , where it produces high levels of
prostaglandins and contributes to
tumor growth . -
pubmed
In this study we have analyzed the expression of
COX-2 in a series of 48
skeletal osteosarcomas of different subtypes by immunohistochemistry . -
pubmed
In addition , we examined the effects of the specific
COX-2 inhibitor
Celecoxib on the growth of the
human osteosarcoma cell line
SaOS-2 . -
pubmed
Immunoreactivity for
COX-2 was observed in 39 out of 48
tumors ( 81.2 % ) , 30 ( 76.9 % ) of which showed a moderate or diffuse immunostaining . -
pubmed
Considering the group of 42 primary
osteosarcomas ,
COX-2 immunoreactivity was significantly higher in
high grade osteosarcomas , where moderate or diffuse expression was detected in 23 out of 32 cases ( 71.8 % ) , than in
low grade osteosarcomas , where moderate or diffuse expression was detected in 2 out of 10 cases ( 20 % ) ( P = 0.008 , Fisher exact test ) . -
pubmed
In
SaOS-2 osteosarcoma cells , which express
COX-2 , treatment with
Celecoxib determined inhibition of cell proliferation and induction of apoptosis . -
pubmed
These results indicate that
COX-2 is expressed at high levels in
high grade osteosarcomas and support the use of
COX-2 inhibitors to improve both the
tumor response to chemotherapy and the outcome of
osteosarcoma patients . -
pubmed
To investigate potential adaptive immune mechanisms in
IPF , we compared phenotypes and effector functions of peripheral CD4 T cells , autoantibody production , and proliferative responses of pulmonary hilar lymph node
CD4 T cells to autologous lung extracts from afflicted
patients and normals . -
pubmed
Our results show that greater proportions of peripheral
CD4 T lymphocytes in
IPF subjects expressed
MHC class II and
CD154 (
CD40L ) , and they more frequently elaborated
TGF - beta1 ,
IL-10 , and
TNF - alpha . -
pubmed
Abnormal
CD4 T cell clonal expansions were found in all
IPF patients , and 82 % of these subjects also had
IgG autoantibodies against
cellular Ags . -
pubmed
OBJECTIVE AND DESIGN :
Cytokine - mediated immunoresponses are consequences of isolated
traumatic brain injury (
TBI ) and
muskuloskeletal trauma but little is known when both impacts occur simulanteously in combined
neurotrauma (
CNT ) , i. e.
TBI +
muskuloskeletal trauma (
bone fracture ) . -
pubmed
MATERIALS AND METHODS : A " two - hit"-experimental model of CNT (
TBI + tibia fracture ) was used to investigate circulating cytokine
interleukin-1 - beta , - 6 , - 10 and
sTNF - R1 concentrations following
peripheral bone fracture only ,
TBI only and CNT . -
pubmed
Blood samples were drawn at 30 min , 6 h , 24 h , 48 h , and 7 days following
trauma and circulating
cytokine concentrations were determined via immunoassay . -
pubmed
RESULTS : Circulating
cytokines were increased after
trauma ( p & lt;0.001 vs. controls ) , but peaked at different time points . -
pubmed
sTNF R1 peaked first at 30 min , followed by
IL-6 at 6 h after
trauma . -
pubmed
IL-10 levels were highest at 24 h , and those for
IL-1beta at 48 h after
trauma . -
pubmed
CONCLUSION : Circulating
cytokine IL-1 - beta , - 6 , - 10 and
sTNF - R1 concentrations are increased after
trauma (
TBI ,
fracture and
CNT ) but peak at different time points . -
pubmed
Pronounced
IL-6 and
IL-10 responses after CNT may contribute to the increased susceptibility for complications in CNT versus
monotrauma . -
pubmed
Thiopurine - methyltransferase and
inosine triphosphate pyrophosphatase polymorphism in a liver transplant recipient developing nodular regenerative
hyperplasia on low - dose
azathioprine . -
pubmed
Increased morbidity and mortality is rarely observed in patients with a
hemoglobin concentration & gt;7 g / dL , and the acute
hemoglobin threshold for
cardiovascular collapse may be as low as 3 g / dL to 5 g / dL. -
pubmed
As
17beta - HSD1 is often overexpressed in
mammary tumors and
endometriosis , the selective inhibition of this enzyme is discussed as a promising approach for the treatment of
estrogen - dependent diseases . -
pubmed
Mucosal immunization with purified
ClpP could elicit protective efficacy against
pneumococcal pneumonia and
sepsis in
mice . -
pubmed
Caseinolytic protease (
ClpP ) has been found to be highly conserved among different strains of
Streptococcus pneumoniae and intraperitoneal immunization with
ClpP could elicit protection against invasive
pneumococcal infections . -
pubmed
In this study , mucosal immunization with
ClpP antigen induced both systemic and mucosal antibodies , and in this way reduced lung colonization in an invasive
pneumococcal pneumonia model and also protected
mice against death in an intraperitoneal -
sepsis model . -
pubmed
CONCLUSIONS : These data show that dual gene therapy with
ER /
GR might be a useful tool for understanding the role of
steroid hormones in the storage of
traumatic memories . -
pubmed
Exendin-4 improves glycemic control , ameliorates brain and pancreatic pathologies , and extends survival in a
mouse model of
Huntington ' s disease . -
pubmed
Huntington ' s disease is a
neurodegenerative disorder caused by a
polyglutamine expansion within the
huntingtin protein . -
pubmed
Similarly to
Huntington ' s disease patients ,
mice expressing the mutated
human huntingtin protein also exhibit neurodegenerative changes ,
motor dysfunction , perturbed energy metabolism , and elevated blood
glucose levels . -
pubmed
RESEARCH DESIGN AND METHODS :
Huntington ' s disease mice were treated with an FDA - approved antidiabetic
glucagon - like peptide 1 receptor agonist , exendin-4 ( Ex-4 ) , to test whether euglycemia could be achieved , whether
pancreatic dysfunction could be alleviated , and whether the
mice showed any neurological benefit . -
pubmed
RESULTS :
Ex-4 treatment ameliorated abnormalities in peripheral
glucose regulation and suppressed cellular pathology in both brain and pancreas in a
mouse model of
Huntington ' s disease . -
pubmed
CONCLUSIONS : Targeting both peripheral and neuronal deficits ,
Ex-4 is an attractive agent for therapeutic intervention in
Huntington ' s disease patients suffering from
diabetes . -
pubmed
Subjects who were positive for both
IgA -
AGA and
IgA - EMA were classified as having
CD . -
pubmed
Of the 192
patients evaluated , only one ( 0.5 % ) was found to have positive for both
IgA - AGA and
IgA EMA tests and accepted as having
CD . -
pubmed
Further , we examined changes in
phospho protein kinase A (
pPKA ) levels following an immediate and a delayed onset of reaching training in
rats with
cervical SCI . -
pubmed
Strikingly , only delayed reaching training restored cortical
PKA levels that had dropped significantly over 2 weeks post -
injury . -
pubmed
The further distribution of the MEMP
patients ' group was the following--5
patients had MEMP with
lactic acidosis , 5 had
Leigh ' s disease ( subacute necrotizing
encephalopathy ) , from which 1 had
cytochrome - c - oxidase deficiency (
COX ) . -
pubmed
Among them the
ornithine transcarbamylase (
OTC ) heterozygous female
patient with left - sided
hemiparesis caused by
hyperammonemic stroke at 10 month - age , showed
right sided temporoparietal , occipital and left frontal hypoperfusion , nearly 6 years after the
cerebral vascular attack . -
pubmed
Endothelial dysfunction is intricately related to
insulin resistance through the parallel stimulatory effects of
insulin on
glucose disposal in metabolic tissues and
NO production in the endothelium . -
pubmed
Constitutively active inflammasome in
human melanoma cells mediating
autoinflammation via
caspase-1 processing and secretion of
interleukin-1beta . -
pubmed
Interleukin-1beta (
IL-1beta ) is a pleiotropic
cytokine promoting
inflammation , angiogenesis , and tissue remodeling as well as regulation of immune responses . -
pubmed
Although
IL-1beta contributes to growth and metastatic spread in experimental and
human cancers , the molecular mechanisms regulating the conversion of the inactive
IL-1beta precursor to a secreted and active
cytokine remains unclear . -
pubmed
Late stage
human melanoma cells spontaneously secrete active
IL-1beta via constitutive activation of the
NALP3 inflammasome and
IL-1 receptor signaling , exhibiting a feature of
autoinflammatory diseases . -
pubmed
In contrast ,
NALP3 functionality in intermediate stage melanoma cells requires activation of the
IL-1 receptor to secrete active
IL-1beta ; cells from an early stage of
melanoma require stimulation of the
IL-1 receptor plus the co - stimulant
muramyl dipeptide . -
pubmed
These findings implicate
IL-1 - mediated
autoinflammation as contributing to the development and progression of
human melanoma and suggest that inhibiting the inflammasome pathway or reducing
IL-1 activity can be a therapeutic option for
melanoma patients . -
pubmed
Plasma N - terminal fragment of the
prohormone B - type natriuretic peptide concentrations in relation to time to treatment and
Thrombolysis in Myocardial Infarction ( TIMI ) flow : a substudy of the Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention ( ASSENT IV - PCI ) trial . -
pubmed
BACKGROUND : We investigated the prognostic significance of plasma N - terminal fragment of the
prohormone B - type natriuretic peptide (
Nt - proBNP ) concentrations in addition to time to reperfusion and
Thrombolysis in Myocardial Infarction ( TIMI ) flow before and after coronary intervention in
patients with
ST elevation myocardial infarction (
STEMI ) from the database of the Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention ( ASSENT IV - PCI ) trial . -
pubmed
METHODS :
Plasma Nt - proBNP was available in 1,037
patients with
STEMI . -
pubmed
Discovery of
7 -( 4 -( 3 - ethynylphenylamino )- 7 - methoxyquinazolin-6 - yloxy )- N - hydroxyheptanamide (
CUDc-101 ) as a potent multi - acting
HDAC ,
EGFR , and
HER2 inhibitor for the treatment of
cancer . -
pubmed
These results suggest that a single compound that simultaneously inhibits
HDAC ,
EGFR , and
HER2 may offer greater therapeutic benefits in
cancer over single - acting agents through the interference with multiple pathways and potential synergy among
HDAC and
EGFR /
HER2 inhibitors . -
pubmed
Protease - activated receptor-1 (
PAR1 ) is a G protein - coupled receptor that plays critical roles in
cancer , angiogenesis ,
inflammation , and
thrombosis . -
pubmed
Unexpectedly ,
BicD1 was also found to be a potent suppressor of
PAR1 - driven proliferation of
breast carcinoma cells . -
pubmed
The aim of this study was to analyze , by FISH for 5q31 (
EGR1 ) , a series of 28
MDS and
AML cases with monosomy 5 detected by G - banding . -
pubmed
Prognostic relevance of
KIT and
PDGFRA mutations in
gastrointestinal stromal tumors . -
pubmed
Here , we aimed to assess whether
KIT and
PDGFRA mutations have survival impact in
gastrointestinal stromal tumors (
GIST ) . -
pubmed
PATIENTS AND METHODS : Fifty - five Brazilian
patients with completely resected
GIST were examined for
KIT and
PDGFRA mutations . -
pubmed
The 5 - year DFS rate was lower in patients with
tumors having in - frame deletions or concomitant in - frame deletions and insertions affecting codons 557 - 558 than in patients with
tumors having other exon 11
KIT mutations ( p=0.023 ) . -
pubmed
CONCLUSION : Our findings indicate that a specific
KIT mutation may be associated with unfavorable behavior in
GIST . -
pubmed
Uncontrolled studies suggest that
prostacyclin analogues and
phosphodiesterase type-5 inhibitors may have benefits in advanced
pulmonary vascular disease . -
pubmed
Accumulative in vivo evidence shows that increased bone resorption occurs at an early stage in the development of
osteoarthritis and that blocking bone - resorbing
cytokines prevents
cartilage damage , confirming the role of bone factors in the crosstalk of both tissues . -
pubmed
This review will summarize what is known about the contribution of bone
cytokines to the physiological remodeling of cartilage and in the pathophysiology of
osteoarthritis . -
pubmed
[ Effect of
vitamin C on the condition of
NO - synthase system in experimental
stomach ulcer ] . -
pubmed
We investigated the effect of
Vitamin C (
Vit C ) on the changes of activity of the enzymes of
NO - synthase system ,
nitric oxide content , lipoperoxidation processes , activity of
SOD and
catalase in gastric mucosa ( GM ) , and concentrations of
L - arginine ,
Vit C and
Vit E in the blood of
rats under conditions of experimental
ulcer of the stomach caused by
adrenaline injection . -
pubmed
Survivin knockdown could induce
cancer cell apoptosis and inhibit tumor - angiogenesis . -
pubmed
ARID1A expression loss in
gastric cancer : pathway - dependent roles with and without
Epstein - Barr virus infection and
microsatellite instability . -
pubmed
The AT - rich interactive domain 1A gene (
ARID1A ) , which encodes one of the subunits in the Switch /
Sucrose Nonfermentable chromatin remodeling complex , carries mutations and is responsible for loss of protein expression in gastric
carcinoma , particularly with
Epstein - Barr virus ( EBV ) infection and a
microsatellite instability - high phenotype . -
pubmed
We used immunohistochemistry to investigate the significance of
ARID1A loss in 857 gastric
carcinoma cases , including 67 EBV(+ ) and 136
MLH1 - lost gastric
carcinomas ( corresponding to a
microsatellite instability - high phenotype ) . -
pubmed
Loss of
ARID1A expression was significantly more frequent in EBV(+ ) ( 23/67 ; 34 % ) and
MLH1 - lost ( 40/136 ; 29 % ) gastric
carcinomas than in EBV(-)
MLH1 - preserved ( 32/657 ; 5 % ) gastric
carcinomas ( P & lt ; 0.01 ) . -
pubmed
Loss of
ARID1A correlated with larger
tumor size , advanced invasion depth , lymph node metastasis , and poor prognosis in EBV(-)
MLH1 - preserved gastric
carcinoma . -
pubmed
A correlation was found only with
tumor size and diffuse - type histology in
MLH1 - lost gastric
carcinoma , but no correlation was observed in EBV(+ ) gastric
carcinoma . -
pubmed
Loss of
ARID1A expression in EBV(+ ) gastric
carcinoma was highly frequent in the early stage of gastric
carcinoma , although
EBV infection did not cause downregulation of
ARID1A : EBV - positive nasopharyngeal
carcinomas ( n = 8) and
lymphomas ( n = 15 ) failed to show loss of
ARID1A , and
EBV infection did not cause loss of
ARID1A in gastric
carcinoma cell lines . -
pubmed
Taken together , loss of
ARID1A may be an early change in carcinogenesis and may precede
EBV infection in gastric epithelial cells , while loss of
ARID1A promotes
cancer progression in
gastric cancer cells without
EBV infection or loss of
MLH1 expression . -
pubmed
Loss of
ARID1A has different and pathway - dependent roles in gastric
carcinoma . -
pubmed
Blood lead ,
delta - aminolevulinic acid dehydratase (
delta - ALAD ) and
zinc protoporphyrin (
ZPP ) concentrations are widely used as biomarkers for
lead toxicity The present study was designed to determine the impact of chronic lead exposure on selected biological markers . -
pubmed
[ Monoclonal antibodies targeting
IL-17A or its receptor in
psoriasis : a new therapeutic approach ? ] -
pubmed
alpha - Lipoic acid ameliorates
mitochondrial impairment and reverses apoptosis in
FABP3 - overexpressing embryonic cancer cells . -
pubmed
We have previously shown
FABP3 was more highly expressed in myocardium with
ventricular septal defects than in normal myocardium and furthermore , that overexpression of
FABP3 causes
mitochondrial dysfunction and induces apoptosis in the
P19 mouse teratocarcinoma cell line (
P19 ) , which is a suitable model for the investigation of cardiac differentiation at the molecular and functional levels . -
pubmed
In this study , we established an
FABP3 - overexpressing
P19 cell line for the investigation of the impact of
alpha - LA on
mitochondrial impairment and apoptosis in these cells . -
pubmed
Collectively , our results indicate that abnormalities in
FABP3 expression contribute to
mitochondrial dysfunction and apoptosis , and that
alpha - LA represents a suitable candidate for development as a treatment for apoptosis - related
congenital cardiac malformations . -
pubmed
OBJECTIVE : To prospectively study the relation between
TSH and risk of
hip and forearm fractures . -
pubmed
METHODS : In a substudy of the second survey of the Nord Trondelag Health Study , Norway ( HUNT2 , 1995 - 97 ) , linked with a hospital - based
fracture registry , we investigated the relation between baseline
TSH and risk of
hip and / or forearm fractures . -
pubmed
Overall , there was no relation between baseline
TSH and
fracture risk . -
pubmed
However , there was weak evidence that women with
TSH & lt;0.5 and & gt;3.5 mU / l had a slightly increased risk of
hip fractures ( hazard ratio ( HR ) 1.30 , 95 % CI 0.97 - 1.94 and HR 1.19 , 95 % CI 0.93 - 1.52 ) compared with the reference group with
TSH of 1.5 - 2.4 mU / l. Supplementary analyses showed higher
hip fracture risk in women with
TSH & gt;4.0 mU / l and negative
thyroid peroxidase antibodies ( TPOAb ) compared with the reference group ( HR 1.75 , 95 % CI 1.24 - 2.46 ) . -
pubmed
CONCLUSION : We found no statistically significant relation between baseline
TSH and subsequent
fracture risk , but the data suggest a weak positive association with
hip fracture risk among women with both low and high
TSH . -
pubmed
Two distinct approaches have emerged to try to extend survival in
patients with
metastatic melanoma : immunomodulation with anti -
CTLA4 monoclonal antibodies , and targeted therapy with
BRAF inhibitors or
MEK inhibitors for
BRAF - mutated
melanoma . -
pubmed
Anti -
PD1 and anti -
PDL1 antibodies have emerged as breakthrough drugs for
melanoma that have high response rates and long durability . -
pubmed
Biomarkers that have predictive value remain elusive in
melanoma , although emerging data for adjuvant therapy indicate that
interferon sensitivity is associated with ulceration of the primary
melanoma . -
pubmed
Finally , we show that administration of
IL-4 to immunodeficient
mice to regulate
inflammation by induction of type 2 responses also restores parasite development . -
pubmed
Calprotectin (
S100A8 / A9 ) ,
S100A12 , and
EDTA - resistant
S100A12 complexes ( ERAC ) in primary
Sjogren ' s syndrome . -
pubmed
Injury - mediated increased
K (+ ) efflux through
Kv2.1 channels promotes neuronal apoptosis , contributing to widespread neuronal loss in
neurodegenerative disorders such as
Alzheimer ' s disease and
stroke . -
pubmed
Kv1 and
Kv7 channel dysfunction leads to neuronal hyperexcitability that critically contributes to the pathophysiology of
human clinical disorders such as
episodic ataxia and
epilepsy . -
pubmed
This review summarizes the
neurotoxic , neuroprotective , and neuroregulatory roles of
Kv channels and highlights the consequences of
Kv channel dysfunction on neuronal physiology . -
pubmed
The studies described in this review thus underscore the importance of normal
Kv channel function in neurons and emphasize the therapeutic potential of targeting
Kv channels in the treatment of a wide range of
neurological diseases . -
pubmed
As confirmed by qRT - PCR , microarray data showed a significant ( P & lt ; .005 ) upregulation of
cytokines and
chemokines (
IL-6 ,
CCL2 ,
CXCL1 ,
AIMP1 , and
CD44 ) just 5 hours after
injury . -
pubmed
Immunohistochemistry demonstrated that
CCL2 and the adhesion receptor
CD44 were expressed by SMCs in the early response to
injury and in the absence of leukocyte infiltration . -
pubmed
Diabetic patients have characteristic pattern of
dyslipidemia with decreased level of
high density lipoprotein cholesterol (
HDL - C ) and elevated
triglycerides ( TG ) level . -
pubmed
However , in
diabetes mellitus ,
low density lipoprotein cholesterol (
LDL - C ) which is used as one of the markers for the risk of
CVD , is underestimated so in such cases the levels of non - High density lipoprotein
cholesterol ( non -
HDL - C ) can be a stronger predictor of
CVD as it strongly correlates with atherogenic lipoproteins . -
pubmed
Diabetics have significantly elevated ratio of total
cholesterol to
high density lipoprotein cholesterol ( TC /
HDL - C ) and the significant increased levels of non - high density lipoprotein
cholesterol ( non -
HDL - C ) compared to controls which can be used as markers of
dyslipidemia and can also be used to predict the risk of
cardiovascular disease in
type 2 Diabetes Mellitus . -
pubmed
18 - Fluorine fluorodeoxyglucose positron emission tomography in the pretreatment evaluation of
thymic epithelial neoplasms : a metabolic biopsy confirmed by
Ki-67 expression . -
pubmed
We also searched for the expression of a pathological biomarker ,
Ki-67 , that gained both diagnostic and prognostic relevance for various solid
tumours . -
pubmed
CONCLUSIONS :
FDG PET - CT can provide a useful tool in the preoperative work - up of
TEN , reflecting its proliferation capacity , as described also by the
Ki-67 expression . -
pubmed
OBJECTIVE : A phase IIa study investigated efficacy and safety / tolerability of ascending doses of mavrilimumab ( anti -
granulocyte - macrophage colony - stimulating factor receptor [
GM - CSFR ] alpha monoclonal antibody ) in adult
subjects with moderate to severe
rheumatoid arthritis from Japan and Europe . -
pubmed
CONCLUSIONS : A rapid and clinically meaningful response was seen in subjects treated with
GM - CSFRalpha blockade with mavrilimumab , supporting further investigation of mavrilimumab for the treatment of
RA in Japanese subjects . -
pubmed
Primary cutaneous
CD30 - positive
anaplastic large cell lymphoma in an 80 - year - old
man : a case report from Nepal . -
pubmed
MATERIAL AND METHODS : A series of three cases of positive anti -
Ro / SS - A mothers with fetuses showing mild
cardiac involvement were treated with a triple therapy composed of
steroids , plasmapheresis and IVIG . -
pubmed
Caffeine and
Caffeic Acid Inhibit Growth and Modify
Estrogen Receptor and
Insulin - like Growth Factor I Receptor Levels in
Human Breast Cancer . -
pubmed
PURPOSE : Epidemiologic studies indicate that dietary factors , such as
coffee , may influence
breast cancer and modulate
hormone receptor status . -
pubmed
The purpose of this translational study was to investigate how coffee may affect
breast cancer growth in relation to
estrogen receptor - alpha (
ER ) status . -
pubmed
Cellular and molecular effects by the coffee constituents
caffeine and
caffeic acid were evaluated in
ER(+ ) (
MCF-7 ) and
ER(- ) (
MDA - MB-231 )
breast cancer cells . -
pubmed
RESULTS : Moderate ( 2 - 4 cups / day ) to high ( & gt;=5 cups / day ) coffee intake was associated with smaller invasive primary
tumors ( Ptrend = 0.013 ) and lower proportion of
ER(+ )
tumors ( Ptrend = 0.018 ) , compared with
patients with low consumption ( & lt;=1 cup / day ) . -
pubmed
Moderate to high consumption was associated with lower risk for
breast cancer events in
tamoxifen - treated
patients with
ER(+ )
tumors ( adjusted HR , 0.51 ; 95 % confidence interval , 0.26 - 0.97 ) . -
pubmed
CONCLUSIONS : The clinical and experimental findings demonstrate various anticancer properties of
caffeine and
caffeic acid against both
ER(+ ) and
ER (- ) breast cancer that may sensitize
tumor cells to
tamoxifen and reduce
breast cancer growth . -
pubmed
Relationship between
pituitary adenoma texture and
collagen content revealed by comparative study of MRI and pathology analysis . -
pubmed
Preoperative imaging data of 38 cases of
pituitary adenoma patients and
collagen content of
tumor specimens measured by histopathological were analyzed and compared . -
pubmed
T2WI and diffusion coefficient assessment were used to reveal the relationship between
tumor texture and
collagen content . -
pubmed
There were significant differences in
collagen content of different texture
tumors ( P & lt ; 0.01 ) . -
pubmed
Elevated Serum
Pentosidine and Decreased Serum
IGF - I Levels are Associated with Loss of Muscle Mass in Postmenopausal
Women with
Type 2 Diabetes Mellitus . -
pubmed
In this study , we investigated the relationship between serum levels of
pentosidine , which is one of AGEs , and
insulin - like growth factor - I (
IGF - I ) vs. skeletal muscle mass by whole body dual - energy x - ray absorptiometry in 133 postmenopausal
women with
type 2 diabetes . -
pubmed
Moreover , after adjusting for age , duration of
diabetes , serum
creatinine , HbA1c , and
IGF - I ,
pentosidine was significantly and negatively associated with RSMI ( beta=-0.27 , p=0.018 ) and marginally with muscle mass of legs ( beta=-0.18 , p=0.071 ) . -
pubmed
These findings indicate that increased serum
pentosidine and decreased
IGF - I are independent risk factors for
loss of muscle mass in postmenopausal women with
type 2 diabetes . -
pubmed
Randomized Controlled Trial of
Zoledronic Acid plus Chemotherapy versus Chemotherapy Alone as Neoadjuvant Treatment of
HER2 - Negative Primary
Breast Cancer ( JONIE Study ) . -
pubmed
METHODS : Asian
patients with
HER2 - negative invasive
breast cancer were randomly assigned to either the CT or CT+
ZOL (
CTZ ) group . -
pubmed
SET8 induces epithelial - mesenchymal transition and enhances
prostate cancer cell metastasis by cooperating with
ZEB1 . -
pubmed
Mounting evidence suggested that histone H4K20 - specific methyltransferase
SET8 is required to maintain the malignant phenotype of various
cancer types ; however , the role of
SET8 in mediating
tumor metastasis in
prostate cancer (
PCa ) has remained elusive . -
pubmed
The present study demonstrated that small interfering RNA - mediated knockdown of
SET8 inhibited the invasive potential of the
PCa cell line
PC-3 in vitro . -
pubmed
Furthermore ,
SET8 was shown to be physically associated with the epithelial - mesenchymal transition ( EMT ) inducer
zinc finger E - box - binding homeobox 1 (
ZEB1 ) in
PCa cell lines . -
pubmed
In conclusion , the present study revealed that
SET8 and
ZEB1 are functionally interdependent in promoting the EMT and enhancing the invasive potential of
PCa cells in vitro . -
pubmed
Sclerostin antibody prevented progressive
bone loss in combined ovariectomized and concurrent functional disuse . -
pubmed
A
sclerostin - neutralizing antibody (
Scl - Ab ) increased bone mineral density in
women with
postmenopausal osteoporosis and healthy men . -
pubmed
The objective of this study was to characterize the condition of
bone loss in ovariectomized ( OVX )
rats with concurrent mechanical unloading and evaluate the effect of
sclerostin antibody treatment in mitigating the prospective severe
bone loss conditions in this model . -
pubmed
The data suggested that monoclonal
sclerostin - neutralizing antibody represents a promising therapeutic approach for severe
osteoporosis induced by
estrogen deficiency with concurrent mechanical unloading . -
pubmed
RECQ helicases are deregulated in
hematological malignancies in association with a prognostic value . -
pubmed
METHODS : We have investigated the expression of
RECQ helicases in different
hematological malignancies and in their normal counterparts using publicly available gene expression data . -
pubmed
Furthermore , we explored whether
RECQ helicases expression could be associated with
tumor progression and prognosis . -
pubmed
RESULTS : Expression of at least one
RECQ helicase family member was found significantly deregulated in all
hematological malignancies investigated when compared to their normal counterparts . -
pubmed
In addition ,
RECQ helicase expression was associated with a prognostic value in
acute myeloid leukemia ,
chronic lymphocytic leukemia ,
lymphoma and
multiple myeloma . -
pubmed
CONCLUSION :
RECQ helicase expression is deregulated in
hematological malignancies compared to their normal counterparts in association with a prognostic value . -
pubmed
Deregulation of
RECQ helicases appears to play a role in tumorigenesis and represent potent therapeutic targets for synthetic lethal approaches in
hematological malignancies . -
pubmed
Heat shock protein 27 (
HSP27 ,
HSPB1 ) is an anti - apoptotic protein characterized for its tumorigenic and metastatic properties , and now referenced as a major therapeutic target in many types of
cancer . -
pubmed
Therefore , altered dimerization of
HSP27 represents a good strategy for anticancer therapy in
HSP27 - overexpressing
cancer cells . -
pubmed
CONCLUSION :
Bile deficiency in the intestine upregulates the expression of intestinal mucosal
SGLT1 and enhances intestinal mucosal
glucose absorption capacity , which contributes to the understanding of intestinal physiologic function for
patients with
biliary duct obstruction and external biliary drainage . -
pubmed
Matriptase regulates
c - Met mediated proliferation and invasion in inflammatory
breast cancer . -
pubmed
Dysregulation of
matriptase expression , an epithelial - specific member of the type II transmembrane
serine protease family , has been demonstrated in many different
cancer types . -
pubmed
To date , no studies have assessed the expression and potential pro - oncogenic role of
matriptase in
IBC . -
pubmed
We examined the functional relationship between
matriptase and the
HGF /
c - MET signaling pathway in the
IBC cell lines
SUM149 and
SUM190 , and in
IBC patient samples . -
pubmed
Matriptase and
c - Met proteins are localized on the surface membrane of
IBC cells and their expression is strongly correlated in infiltrating
cancer cells and in the
cancer cells of
lymphatic emboli in
patient samples . -
pubmed
Abrogation of
matriptase expression by silencing with RNAi or inhibition of
matriptase proteolytic activity with a synthetic inhibitor impairs the conversion of inactive pro -
HGF to active
HGF and subsequent
c - Met - mediated signaling , leading to efficient impairment of proliferation and invasion of
IBC cells . -
pubmed
These data show the potential of
matriptase inhibitors as a novel targeted therapy for
IBC , and lay the groundwork for the development and testing of such drugs . -
pubmed
This is a largest series of 5 cases of
lymphoepithelioma - like carcinoma (
LEC ) of the breast attempting to look at the expression of
basal cytokeratins (
CKs ) ,
human papillomavirus , and
Epstein - Barr virus - encoded RNAs in these
tumors . -
pubmed
All
tumors were negative for
estrogen and progesterone receptors and
HER2 ( triple negative ) . -
pubmed
Three
tumors expressed
CK5 / 6 and high - molecular - weight
CK , whereas only the case with nodal metastasis expressed
CK14 . -
pubmed
One
patient with
tumor expressing basal marker ,
CK5 / 6 , had contralateral
breast malignancy after a duration of 53 months of treatment completion . -
pubmed
The
lymphoepithelioma - like
carcinoma of breast expressed basal
CK profile that is more
CK5 / 6 positive than
CK14 . -
pubmed
Results from exomic sequencing revealed mutations in
TP53 consistent with
HGSOC . -
pubmed
These results suggest the first evidence that
curcumin can prevent
Mn - induced microglial cell death through the induction of
HO-1 and regulation of oxidative stress ,
mitochondrial dysfunction , and apoptotic events . -
pubmed
Tuberculosis occurred on an atlantoaxial synovial pannus during
juvenile idiopathic arthritis treated with
TNF inhibitors . -
pubmed
Complex Interplay Between Aging and
Cancer : Role of
TGF - beta Signaling . -
pubmed
Although the fundamental roles of
TGF - beta in
cancer progression have been investigated extensively , recent reports also provide evidence for its direct or indirect links to aging - related processes such as cell proliferation , senescence , stem cell renewal , DNA damage ,
inflammation , and telomere length . -
pubmed
In this review , we present the latest findings regarding the
TGF - beta - regulated convergent and divergent mechanisms controlling the balance between aging and
cancer . -
pubmed
Estrogen - related receptors alpha , beta and gamma expression and function is associated with transcriptional repressor
EZH2 in
breast carcinoma . -
pubmed
BACKGROUND : Orphan nuclear receptors
ERRalpha ,
ERRbeta and
ERRgamma that belong to
NR3B or type IV nuclear receptor family are well studied for their role in
breast cancer pathophysiology . -
pubmed
Although function and regulation of
ERRalpha ,
ERRgamma and less about
ERRbeta is reported , role of histone methylation in their altered expression in
cancer cells is not studied . -
pubmed
The present study for the first time gives an insight into regulation of
estrogen - related receptors by histone methylation specifically through methyltransferase
EZH2 in
breast cancer . -
pubmed
Immunohistochemistry in primary breast
tumors of different grades showed a correlated expression of
estrogen - related receptors and
EZH2 . -
pubmed
Ectopic expression of
EZH2 in low
EZH2 - expressing
normal breast epithelial cells abrogated their expression and at the same time , its silencing enhanced the expression of
estrogen - related receptors in cancerous cells . -
pubmed
CONCLUSION : Our findings identify
EZH2 as a relevant coregulator for
estrogen - related receptors in
breast carcinoma . -
pubmed
Abrogation of the
Circadian Nuclear Receptor REV - ERBalpha Exacerbates
6 - Hydroxydopamine - Induced Dopaminergic
Neurodegeneration . -
pubmed
Considering our previous findings , we hypothesize that
REV - ERBalpha may have a role in the onset and/or progression of
PD . -
pubmed
In the present study , we therefore aimed to elucidate whether genetic abrogation of
REV -
ERBalpha affects
PD - related phenotypes in a
mouse model of
PD produced by a unilateral injection of
6 - hydroxydopamine (
6 - OHDA ) into the dorsal striatum . -
pubmed
In conclusion , the present study demonstrates for the first time that genetic abrogation of
REV - ERBalpha can increase vulnerability of DAergic neurons to
neurotoxic insults , such as
6 - OHDA , thereby implying that its normal function may be beneficial for maintaining DAergic neuron populations during
PD progression . -
pubmed
In this study the autophagy related proteins
Beclin1 and
ATG7 were tested as potential targets to sensitize
colorectal carcinoma cells to ionizing radiation under normoxic , hypoxic and starvation conditions . -
pubmed
Long - term improvement in renal , bone , lipid parameters , and
CD4 /
CD8 ratio in
HIV - infected patients switching to a dual therapy with
lamivudine plus boosted
darunavir . -
pubmed
Improvements in
CD4 /
CD8 ratio ( p = .04 ) , bone mineral density ( +1.17 % ; p = .07 ) , estimated glomerular filtration rate ( +7.7 mL / min in
CKD patients ; p = .02 ) , urinary parameters (
proteinuria , -23 % ) , and overall cost ( -43 % ) were observed . -
pubmed
The Effect of Early Response to
GLP-1 RA Therapy on Long - Term Adherence and Persistence Among
Type 2 Diabetes Patients in the United States . -
pubmed
METHODS :
Adults aged & gt;= 18 years with
T2D initiated with
GLP-1 RA therapy after January 1 , 2010 , were identified from the IBM Explorys Therapeutic Dataset . -
pubmed
After controlling for baseline demographic and clinical characteristics including baseline weight , baseline A1c , oral antidiabetes drug use ,
insulin use , and the presence of comorbidity of
diabetes ,
patients were more likely to be adherent over 18 months if they had reductions in A1c & gt ; 1 % ( OR = 1.59 , 95 % CI = 1.36 - 1.85 ) or body weight reduction & gt ; 3 % ( OR = 1.18 , 95 % CI = 1.02 - 1.36 ) at 3 - 6 months compared with those without an early response . -
pubmed
The spectrum of conditions caused by abnormal
CFTR function is broad - from ' classic '
cystic fibrosis (
CF ) to single organ conditions termed
CFTR - related disorders . -
pubmed
Calprotectin - g the lung during
type 2 allergic airway inflammation . -
pubmed
CONTEXT :
X - linked acrogigantism (
X - LAG ) , a condition of infant - onset
acrogigantism marked by elevated GH , IGF-1 , and
prolactin (
PRL ) , is extremely rare . -
pubmed
For more than 30 years , stable
PRL ,
GH , and
IGF-1 concentrations and serial imaging studies indicated no
tumor recurrence . -
pubmed
In both cases , many
tumor cells expressed
PRL ,
GH , and
pituitary - specific transcription factor-1 . -
pubmed
Furthermore , the
tumor expressed other lineage - specific transcription factors , as well as
SOX2 and
octamer - binding transcription factor 4 , demonstrating the multipotentiality of
X - LAG tumors . -
pubmed
Both showed an elevated
Ki-67 proliferation index , 5.6 % in the mother and 8.5 % in the infant , the highest reported in
X - LAG . -
pubmed
UHRF1 -
KAT7 - mediated regulation of
TUSC3 expression via histone methylation / acetylation is critical for the proliferation of
colon cancer cells . -
pubmed
Here , we show that Wnt /
c - Myc signaling upregulates
UHRF1 , which in turn downregulates
TUSC3 , a candidate
tumor suppressor gene that is frequently deleted or downregulated in several
cancers . -
pubmed
We also show that
UHRF1 - mediated downregulation of
TUSC3 is required for the proliferation of
colon cancer cells . -
pubmed
Our study provides evidence for the significance of
UHRF1 -
KAT7 - mediated regulation of histone methylation / acetylation in the proliferation of
tumor cells and in a diverse set of biological processes controlled by Wnt /
c - Myc signaling . -
pubmed
Use of anti -
vascular endothelial growth factor drugs for
eye disease in Tuscany : Development and test of indicators of treatment intensity . -
pubmed
Logistic and linear regression models were employed to explore relationships between air pollutants , blood lipids ( TC , TG ,
HDL - C and
LDL - C ) and prevalence of
dyslipidemias . -
pubmed
Overall , increased air pollution exposure was related to increased TC and
LDL - C , while decreased TG and
HDL - C. Each 1 - mug / m3 increment of PM2.5 was related to 0.10 % ( 0.07%-0.19 % ) increase in TC , 0.63 % ( 0.50%-0.77 % ) increase in
LDL - C , 2.93 % ( 2.70%-3.16 % ) decrease in TG , 0.49 % ( 0.38%-0.60 % ) decrease in
HDL - C ; and 5.7 % ( 95%CI : 3.7%-7.6 % ) , 4.0 % ( 95%CI : 2.1%-6.0 % ) and 3.8 % ( 95%CI : 2.5%-5.1 % ) increase in odds for
hypercholesterolemia ,
hyperbetalipoproteinemia and
hypoalphalipoproteinemia , respectively . -
pubmed
Attenuation of
Inflammation and
Leptin Resistance by
Pyrogallol - Phloroglucinol-6,6 - Bieckol on in the Brain of Obese
Animal Models . -
pubmed
Activated macrophage infiltration , polarization of macrophages to a more inflammatory type ( M1 ) , and increased levels of pro - inflammatory cytokines are related to
brain inflammation , which induces
leptin resistance in the brain . -
pubmed
In this study , we evaluated the effects of
PPB effect M1 polarization and
inflammation and its ability to restore the effects of
leptin , such as a decrease in appetite and body weight . -
pubmed
We administered
PPB to diet - induced
obesity ( DIO ) and
leptin - deficient ( ob / ob )
mice , evaluated macrophage activation , polarization , and changes of inflammatory cytokine level in adipose tissue and brain , and determined the effect of PPB on
leptin resistance or
leptin sensitivity in the brain . -
pubmed
PPB decreased
inflammation in the brain , restored
leptin sensitivity , and decreased food intake and
weight gain in both DIO and ob / ob
mice . -
pubmed
The
patient had normal
albumin and renal function but was
vitamin D deficient . -
pubmed
A phase 1 study evaluating safety and pharmacokinetics of losatuxizumab vedotin (
ABBV-221 ) , an anti -
EGFR antibody - drug conjugate carrying
monomethyl auristatin E , in
patients with
solid tumors likely to overexpress
EGFR . -
pubmed
In this multicenter phase 1 study , eligible
patients with
EGFR - dependent
solid tumors received losatuxizumab vedotin ( 3 + 3 design ) intravenously at starting dose of 0.3 mg / kg over 3 h per 21 - day cycle , with alternate dosing schedules utilized ( 2 weeks on/1 week off or weekly ) to mitigate infusion reactions . -
pubmed
Tumor samples were evaluated for
EGFR protein expression by immunohistochemistry ,
EGFR and
EGFR ligand mRNA expression by RNAseq , and results compared with outcome . -
pubmed
One
HNC patient with increased levels of
EGFR and
EGFR ligands (
amphiregulin ,
epiregulin ) achieved a confirmed partial response . -
pubmed
[ Expression Level of
LKB1 Gene in Patients with
Acute Lymphoblastic Leukemia and Its Correlation with Illness Condition ] . -
pubmed
OBJECTIVE : To evaluate the expression level of
LKB1 gene in
patients with
acute lymphoblastic leukemia (
ALL ) , and analyze its correlation with illness condition of
patients . -
pubmed
Patients in
ALL group were divided into two groups according to the expression level of
LKB1 gene : low expression group ( 39 cases ) and high expression group ( 17 cases ) . -
pubmed
RESULTS : The expression level of
LKB1 gene of control group was 1.56(1.38 - 1.74)>
ALL group 1.32(1.22 - 1.40)>
ANLL group 0.89(0.78 - 1.02 ) . -
pubmed
There was negative relation between expression level of
LKB1 gene and clinical risk level of
ALL patients ( r=-0.712 , P=0.039 ) . -
pubmed
For standard risk
ALL , the
patients in
LKB1 low expression group was significantey lower than that in high expression group ; and for high risk
ALL , the
patients in
LKB1 low expression group was significant higher than that in high expression group . -
pubmed
Multivariate logistic analysis showed that the age ( OR=2.872 , P=0.020 ) , peripheral blood immature cell count ( OR=2.268 , P=0.028 ) were independent risk factors for survival of
patients with
ALL , and the expression level of
LKB1 gene ( OR=0.426 , P=0.016 ) is protective factor . -
pubmed
CONCLUSION : The expression level of
LKB1 gene in
patients with
ALL is low , moreover the more low expression level of
LKB1 gene were , the more severe ill condition and more poor prognosis were . -
pubmed
Serum
NO and
H2O2 concentrations increased significantly and were related to
muscle damage (
CK activity > 900 IU / mL ) in IHE and
Arg / IHE compared to placebo . -
pubmed
The understanding of the molecular landscape of
BTC has offered hope of targeted therapies to the identified actionable genomic aberrations , such as
FGFR2 gene fusions , mutations of
IDH1 / 2 ,
HER2 ,
BRAC1 / 2 and
BRAF . -
pubmed
Pembigatinib has become the first approved targeted therapy for
BTC with
FGFR2 fusion or other rearrangements . -
pubmed
Recent immunotherapy has opened new therapy avenues in
BTC with pembrolizumab approved for either
microsatellite instability high (
MSI - H ) or
DNA mismatch repair deficient (
dMMR ) advanced
solid tumors , including
BTC . -
pubmed
Electroacupuncture Pretreatment Alleviates LPS - Induced
Acute Respiratory Distress Syndrome via Regulating the
PPAR Gamma / NF - Kappa B Signaling Pathway . -
pubmed
Excellent therapeutic success of the anti -
interleukin 4 receptor - alpha antibody dupilumab in clinical trials and a real - world clinical context indicates the crucial roles of
interleukin ( IL )- 4 and
IL-13 in the pathogenesis of
AD . -
pubmed
Along with the clinical improvement in skin scores and
pruritus , dupilumab significantly and progressively reduces and normalizes the upregulated expression of T helper type 2 signatures such as
Chemokine ( C - C motif ) ligand ( CCL ) 17 ,
CCL18 ,
CCL22 , and
CCL26 in the lesional skin of
AD . -
pubmed
Gene expression analysis in
epileptic hippocampi reveals a promoter haplotype conferring reduced
aldehyde dehydrogenase 5a1 expression and responsiveness . -
pubmed
Here , we have scrutinized whether two linked regulatory SNPs ( rs2744575 ; 4779C > G and rs4646830 ; 4854C > G ) located in the
aldehyde dehydrogenase 5a1 (
succinic semialdehyde dehydrogenase ;
ALDH5A1 ) gene promoter are associated with expression of corresponding mRNAs in
epileptic hippocampi ( n = 43 ) . -
pubmed
Aberrant
ALDH5A1 promoter regulation in functional terms can contribute to impaired
gamma - aminobutyric acid homeostasis and thereby network excitability and
seizure propensity . -
pubmed
Objectives :
Type I interferons (
IFNs ) inhibit regulatory T - cell ( Treg ) expansion and activation , making them beneficial in antiviral responses , but detrimental in
autoimmune diseases . -
pubmed
Methods :
ISG15 expression and Treg dynamics were analysed in vitro and ex vivo from
patients with
chronic hepatitis C , with lupus and
ISG15 deficiency . -
pubmed
In vivo , in
patients with
chronic hepatitis C , 2 days after starting pegIFN /
ribavirin therapy , a stronger
ISG15 inducibility correlates with a milder Treg depletion . -
pubmed
Ex vivo , in
systemic lupus erythematosus patients , higher levels of
ISG15 are associated to reduced
STAT1 phosphorylation in response to
IFNalpha , and also to increased frequencies of Tregs , characterising active disease . -
pubmed
However , compared to the CON , IMO reduced the
diarrhea rate of suckling piglets ( P < 0.05 ) and improved the concentrations of colostrum
IgA ,
IgG , and
IgM ( P < 0.05 ) . -
pubmed
The use of amnion - derived cellular
cytokine solution for the treatment of
gingivitis : A two week safety , dose - ranging , proof - of - principle randomized trial . -
pubmed
BACKGROUND : A 6 - week Phase I clinical trial was performed to primarily evaluate the safety and secondarily determine the preliminary efficacy of a novel biological solution , ST266 , comprised of a mixture of
cytokines ,
growth factors , nucleic acids , and lipids secreted by
cultured Amnion - derived Multi - potent Progenitor cells on
gingival inflammation . -
pubmed
Treatment of
Herpesvirus saimiri (
HVS)-infected
owl monkey cells by limited
papain digestion removed the
HVS - induced membrane antigen (
MA ) as determined by membrane immunofluorescence and antibody - dependent lymphocyte
cytotoxicity ( ADLC ) . -
pubmed
Effects of dietary
magnesium supplementation on diurnal variations of blood pressure and plasma
Na + , K (+)- ATPase activity in essential
hypertension . -
pubmed
These results support the view that oral
magnesium supplementation is a useful approach to treatment of
patients with uncomplicated essential
hypertension , especially those with high plasmas
renin activity . -
pubmed
It appears that
magnesium suppresses circulating
Na + , K (+)- ATPase inhibitory activity to attenuate vascular tone , and thereby reduces blood pressure in
EH . -
pubmed
Proteinase - resistant prion protein accumulation in
Syrian hamster brain correlates with regional pathology and
scrapie infectivity . -
pubmed
Multiple lines of evidence indicate that
PrPSc , found only in
scrapie , is a necessary component of the infectious
scrapie agent . -
pubmed
We measured the regional concentration of
PrPSc in nine brain regions throughout the course of
scrapie in the
Syrian hamster following intrathalamic inoculation of prions . -
pubmed
PrPSc was compared to the regional concentration of
glial fibrillary acidic protein , a measure of reactive astrocytic
gliosis . -
pubmed
Brain
PrPSc , determined by summing the concentrations in each brain region , correlated well with scrapie infectivity titers throughout the course of
infection ( correlation coefficient = 0.975 ; slope of linear regression line = 1.136 ) . -
pubmed
Our results support the hypothesis that
PrPSc participates in both the etiology and pathogenesis of
prion diseases . -
pubmed
A dose finding study of a super long - acting
luteinizing hormone - releasing hormone analog (
leuprolide acetate depot ,
TAP-144 - SR ) in the treatment of
central precocious puberty . -
pubmed
The effect of
leuprolide acetate (
D - Leu6 -[ des - Gly10 - NH2 ]- LH - RH ethylamide acetate ) for depot suspension (
TAP-144 - SR ) , a synthetic analog of
luteinizing hormone - releasing hormone , was examined in three doses in 36
patients ( 34
girls , 2
boys ) with
central precocious puberty . -
pubmed
A dose of more than 30 micrograms / kg of
TAP-144 - SR is effective in suppressing
gonadotropins and causing improvement of clinical symptoms , and appears to be useful in treating
children with
central precocious puberty . -
pubmed
These patients were mostly men , had a family history of premature
CAD , and 60 % ( 414 of 690 ) had
high - density lipoprotein (
HDL )
cholesterol less than 0.90 mmol / liter ( 35 mg / dl ) . -
pubmed
In a separate group of patients defined from the same admission population but having angiographically established
CAD , 32 % ( 424 of 1,197 ) had a total
cholesterol less than 5.17 mmol / liter ( 200 mg / dl ) , 59 % of whom ( 252 of 424 ) had
HDL less than 0.90 mmol / liter ( 35 mg / dl ) . -
pubmed
An analysis of persons admitted electively for angiography ( to exclude any effects of hospitalization per se on serum lipids ) revealed a similar proportion of persons with total
cholesterol less than 5.17 mmol / liter ( 200 mg / dl ) ( 35 % ) ,
CAD ( 82 % ) , and
HDL less than 0.90 mmol / liter ( 35 mg / dl). -
pubmed
In
cystic fibrosis amniotic fluids , measurements of
fIALP antigen levels resulted in a lower false - negativity outcome than
fIALP enzyme activity measurements , whereas in amniotic fluids of trisomy pregnancies
fIALP enzyme activities and
fIALP antigen levels were equally unpredictive . -
pubmed
beta - Endorphin /
beta - lipotropin immunoreactivity in endogenous
depression . -
pubmed
This study addresses the question of whether pituitary peptides ( ie ,
beta - endorphin ) show regulatory disruption in endogenous
depression and , if so , does it co - occur in the same
subjects who show
cortisol dysregulation . -
pubmed
Endogenously
depressed patients and
psychiatric controls from three centers were evaluated , when not taking medications , and studied for plasma
cortisol and
beta - endorphin levels . -
pubmed
When abnormality of either the
beta - endorphin or
cortisol is considered it is clear that both levels of the hypothalamic - pituitary - adrenal axis can be dysregulated in endogenous
depression . -
pubmed
Antibodies to
neurofilament protein in
retinitis pigmentosa . -
pubmed
Drug metabolite toxicity assessed in
human lymphocytes with a purified , reconstituted
cytochrome P-450 system . -
pubmed
Exostoses have already been studied and explained by the action of
BAPN (
lysyl oxidase ) . -
pubmed
Additional analysis of
IgM and
fibrinogen was neither helpful in identifying
neonatal infections nor a valuable follow - up parameter of successful treatment . -
pubmed
In contrast
C - reactive protein (
CRP ) was increased in 88 % of all infants with
neonatal septicemia and/or
meningitis at time of diagnosis ; when used in combination neutrophil indexes and
CRP even improved the sensitivity of a single laboratory screening test . -
pubmed
Effect of metabolic inhibitors on the agglutination of
tumor cells by concanavalin A and
Ricinus communis agglutinin . -
pubmed
A
collagen defect causing
osteomalacia . -
pubmed
The unsaturated
vitamin B12 binding capacity ( UBBC ) of serum , the three
transcobalamins (
TC I ,
TC II ,
TC III ) , and the total leucocyte and neutrophil counts have been studied in paediatric
patients with
sickle cell disease (
SCD ) . -
pubmed
Species - specificity antigens ,
Forssman antigen and antigen similar to
human B - isoantigen were revealed in the cells of both the intraspecies and all interspecies
hepatoma hybrids . -
pubmed
One mechanism of the immune suppression in
HIV infection has been postulated as being caused by the interaction of
HIV envelope glycoprotein gp120 with
CD4 molecules . -
pubmed
These studies indicate that the
CD4 -
gp120 interaction results in dysregulation of expression of
costimulatory molecules ,
CD40L , and
B71 expression on T cells and APC , respectively , thereby contributing to the T cell hyporesponsiveness in
HIV infection . -
pubmed
Coexpression of
TGF alpha ,
epidermal growth factor receptor , and
P - glycoprotein in
normal and benign diseased breast tissues . -
pubmed
Twenty - four
normal or
benign breast tissues were examined for the expression of
transforming growth factor - alpha (
TGF alpha ) ,
epidermal growth factor receptor (
EGFR ) , and
P - glycoprotein , the product of the
mdr-1 gene . -
pubmed
Coexpression of
EGFR ,
TGF alpha , and
P - glycoprotein in
normal human breast tissues suggests a role for each of those proteins in
normal breast physiology . -
pubmed
An interaction may be present in
normal breast tissue between the
EGF receptor pathway and
P - glycoprotein . -
pubmed
Excitatory amino acid receptors and their role in
epilepsy and
cerebral ischemia . -
pubmed
Increase in activated
CD8 + cells in bronchoalveolar lavage fluid in
patients with
diffuse panbronchiolitis . -
pubmed
DPB patients , however , had a higher number of lymphocytes and a reduced
CD4 /
CD8 ratio compared with the other subjects . -
pubmed
A two - color analysis of T - cell subsets in peripheral blood and BALF revealed a significant increase in the percentage and number of
CD8+
HLA - DR+ cells and in the number of
CD4+
HLA - DR+ cells in BALF of
DPB patients . -
pubmed
The expression of the
adhesion molecules CD 11a and
CD18 on lung CD3 + cells was enhanced over that on blood CD3 + cells in
DPB patients . -
pubmed
There was no significant relationship between BALF
interleukin ( IL )- 8 and lymphocyte accumulation in the lungs of the
DPB patients , whereas a significant correlation between the percentage of neutrophils and
IL-8 levels in BALF of
DPB patients was observed . -
pubmed
After treatment with
macrolide antibiotics , a significant reduction in the number of lymphocytes and activated
CD8 + cells and an elevation in the
CD4 /
CD8 ratio in BALF of
DPB patients was observed . -
pubmed
Effects of
insulin therapy , however , were observed in later stages of
DM : 71 % and 62 % survival in the 6- and 12 - week group , respectively . -
pubmed
[
C - reactive protein in
bacterial meningitis in adults ] . -
pubmed
In order to assess the benefits of serial assays of
C - reactive protein in the course of
bacterial meningitis in adults , daily blood samples were taken for
CRP measurement during 10 days in 21 consecutive
patients ( mean age : 24 + /- 8 years ) hospitalized for
bacterial meningitis principally due to
Neisseria meningitidis ( n = 15 ) . -
pubmed
The highest
CRP level ( 178 + /- 38 mg / l ) was present on admission , followed by a regular decrease occurring in uncomplicated
meningitis until normal level was achieved on day 9 . -
pubmed
The benefit of
CRP assays in optimizing the duration of antibiotic treatment of
meningitis needs to be more carefully assessed . -
pubmed
Memory deficits and cholinergic impairments in
apolipoprotein E - deficient
mice . -
pubmed
Morris Water Maze tasks revealed
impairments in working memory but not in reference memory of the
apoE - deficient
mice . -
pubmed
In addition ,
hypothermia induced by the centrally acting muscarinic agonist ,
oxotremorine , was reduced in the
apoE - deficient
mice as compared to controls . -
pubmed
Recent studies have identified multiple sequence variants of
IRS-1 , especially in
patients with
non - insulin - dependent diabetes mellitus . -
pubmed
These data indicate that the mutation in codon 972 in
IRS-1 impairs
insulin - stimulated signaling , especially along the
PI 3 - kinase pathway , and may contribute to
insulin resistance in normal and
diabetic populations . -
pubmed
This study looks at
p53 protein expression in
dysplastic and
malignant lesions of the oral cavity using an immunohistochemical staining technique . -
pubmed
Positive immunohistochemical detection of the
p53 protein , demonstrated by brown nuclear staining , was detectable in over 80 % of mild , moderate and severe dysplastic tissues as well as
carcinoma - in - situ and
squamous carcinoma specimens . -
pubmed
We concluded that
p53 protein expression occurs frequently in both malignant and
dysplastic lesions of the oral cavity , suggesting that abnormally detectable
p53 protein is present at the very early stages of development of
oral squamous carcinoma . -
pubmed
Diminished
TCR signaling in
cutaneous T cell lymphoma is associated with decreased activities of
Zap70 ,
Syk and
membrane - associated Csk . -
pubmed
The results obtained from analysis of
tumor cells from four patients show a general reduction in basal and induced
tyrosine phosphorylation of a wide range of
signaling proteins . -
pubmed
We propose that dampened
TCR - triggered responses in
CTCL are caused by suppression of an array of
effector molecules required for coupling
cell surface receptors to early and late signaling events . -
pubmed
This new approach , taking advantage of the ability of truncated
HIV envelope glycoproteins to be incorporated into heterologous retroviral particles , may foreseeably be used in future interventions based on the coordinated delivery of therapeutic gene products specifically to cell types susceptible to
HIV infection . -
pubmed
Results obtained in experimental
animals indicate that
AII - A effectively prevents the progression of
renal injury . -
pubmed
Several clinical studies are in progress , and the preliminary results suggest that
AII - A has potent renal protective action in a variety of
renal disorders . -
pubmed
This study set out to investigate the importance of
vomiting in producing the raised
serum amylase and to clarify whether the
amylase in pancreatic or salivary . -
pubmed
METHODS :
Patients suffering from
hyperemesis gravidarum who were repeatedly
vomiting in pregnancy but not binge eating had their total serum and
pancreatic amylase measured . -
pubmed
RESULTS : Results show 45 % ( 5 ) of
bulimic patients had raised
serum amylase , but none had a raised
pancreatic amylase . -
pubmed
DISCUSSION : Of
patients with
hyperemesis gravidarum who repeatedly vomit but do not binge , a significant number had raised
amylase . -
pubmed
This suggests that it is the
vomiting rather than the binge behavior that increases
amylase in
bulimic patients . -
pubmed
RESULTS : The
serum BGP values were detected in normal
subjects and six kinds of
bone metabolic diseases . -
pubmed
In 81 normal
subjects , the average
serum BGP level was ( 5.3 + /- 1.5 ) ng / ml and in postmenopausal
osteoporosis the
serum BGP level [ ( 6.2 + /- 1.9 ) ng / ml , n = 42 ] was higher than the normal ( P & lt ; 0.05 ) . -
pubmed
The
serum BGP levels were increased much in
primary hyperparathyroidism [ ( 12.8 + /- 7.0 ) ng / ml , n = 21 , P & lt ; 0.001 ] . -
pubmed
Increased values of
BGP were also found in
patients with
chronic renal failure [ ( 8.5 + /- 2.4 ) ng / ml , n = 18 , P & lt ; 0.01 ] and
Paget ' s disease [ ( 6.7 + /- 2.2 ) ng / ml , n = 12 , P & lt ; 0.05 ] . -
pubmed
Decreased
serum BGP values were found in
Cushing syndrome [ ( 2.9 + /- 0.9 ) ng / ml , n = 16 , P & lt ; 0.001 ] and
hypoparathyroidism [ ( 3.4 + /- 1.1 ) ng / ml , n = 42 , P & lt ; 0.001 ] . -
pubmed
This result showed that in diseases with
high bone turnover , the serum
BGP levels were increased and in diseases with
low bone turnover , the serum
BGP levels were decreased . -
pubmed
A mutation in the promoter of the multidrug resistance gene (
MDR1 ) in
human hematological malignancies may contribute to the pathogenesis of resistant disease . -
pubmed
The overexpression of the multidrug resistance gene
MDR1 has been found to be associated with therapy - resistance in
hematological malignancies . -
pubmed
Point mutations in the
MDR1 promoter have been found in
osteogenic sarcoma ( Stein et al . -
pubmed
We therefore analyzed DNA from
hematological malignancies for
MDR1 promoter point mutations . -
pubmed
[ Mixed
retinal thrombosis in a patient carrying
prothrombin gene mutation in a homozygote state ] . -
pubmed
The normal patched allele is expressed in
medulloblastomas from
mice with heterozygous germ - line mutation of
patched . -
pubmed
Defects in a developmental signaling pathway involving
mammalian homologues of the
Drosophila segment polarity gene ,
patched (
ptc ) and its ligand ,
sonic hedgehog (
shh ) , contribute to
tumor formation in several tissues . -
pubmed
Recently , a subset of
medulloblastoma , the most common
malignant brain tumor in
children , was found to contain somatic mutations in the
human ptc gene . -
pubmed
In addition ,
basal cell nevus syndrome (
BCNS ) , or
Gorlin syndrome , which is characterized by
developmental anomalies and a predisposition to
skin and nervous system malignancies , is associated with germ - line mutation of
ptc . -
pubmed
Targeted disruption of both alleles of
ptc in
mice results in
embryonic lethality . -
pubmed
However ,
ptc+/-
mice survive and develop spontaneous
cerebellar brain tumors , suggesting that
ptc may function as a
tumor suppressor gene . -
pubmed
Therefore , we investigated
ptc+/-
mice as a model for
human medulloblastoma . -
pubmed
We report that 14 % of
ptc+/-
mice develop
central nervous system tumors in the posterior fossa by 10 months of age , with peak
tumor incidence occurring between 16 and 24 weeks of age . -
pubmed
Full - length
ptc mRNA was present in all
tumors analyzed , indicating that there was no loss of heterozygosity at the
ptc locus . -
pubmed
Nucleotide sequence of
ptc mRNA from four
tumors failed to identify any mutations . -
pubmed
High levels of
glil mRNA and protein were detected in the
tumors , suggesting that the
shh /
ptc pathway was activated despite the persistence of
ptc expression . -
pubmed
beta - adrenergic blockade in developing
heart failure : effects on myocardial inflammatory
cytokines ,
nitric oxide , and remodeling . -
pubmed
BACKGROUND : Whether beta - adrenergic blockade modulates myocardial expression of inflammatory
cytokines and
nitric oxide (
NO ) in
heart failure is unclear . -
pubmed
METHODS AND RESULTS : We administered oral
metoprolol or no therapy to
rats for 12 weeks after large
myocardial infarction and subsequently examined left ventricular ( LV ) remodeling ;
myocardial tumor necrosis factor ( TNF )- alpha ,
interleukin ( IL )- 1beta , and
IL-6 expression ; and
NO . -
pubmed
Metoprolol administration starting 48 hours after
infarction ( 1 ) attenuated ( P<0.02 )
LV dilatation and
systolic dysfunction , ( 2 ) preserved
isoproterenol responsiveness ( P<0.025 ) via
NO - independent mechanisms , and ( 3 ) reduced myocardial gene expression and protein production of
TNF - alpha and
IL-1beta ( P<0 . -
pubmed
CONCLUSIONS : During
heart failure development , adrenergic activation contributes to increased myocardial expression of
TNF - alpha and
IL-1beta but not
IL-6 , and one mechanism underlying the beneficial effects of beta - adrenergic blockade may involve attenuation of
TNF - alpha and
IL-1beta expression independent of
iNOS and
NO . -
pubmed
Immunohistochemically , the
tumor cells were positive for
estrogen and progesterone receptors . -
pubmed
Clinical phenotype and anti -
desmoglein autoantibody profile in
paraneoplastic pemphigus . -
pubmed
BACKGROUND :
Paraneoplastic pemphigus (
PNP ) has similar features to
pemphigus vulgaris (
PV ) , including circulating anti -
desmoglein (
Dsg )
IgG as pathogenic autoantibodies . -
pubmed
When
PV is divided into mucosal dominant type and mucocutaneous type , mucosal dominant type has only anti -
Dsg3 IgG , whereas the mucocutaneous type has both anti -
Dsg3 and anti -
Dsg1 IgG. -
pubmed
OBJECTIVE : The purpose of this study was to determine whether there is a difference in anti -
Dsg autoantibody profile between mucosal dominant
PNP and
mucocutaneous PNP . -
pubmed
CONCLUSION : There was no clear association between the clinical phenotype and anti -
Dsg antibody profile in
PNP as seen in PV . -
pubmed
This finding suggests that besides anti -
Dsg IgG other pathologic mechanisms such as
lichenoid reaction or interface
dermatitis may be involved in the blister formation in
PNP . -
pubmed
Effects of oral
steroids on blood
CXCR3 + and
CCR4 + T cells in
patients with
bronchial asthma . -
pubmed
In the
steroid - treated
asthma group , there was a decrease in
CCR4 + T cells ( from 29.3 % to 20.3 % , p & lt ; 0.0001 ) , and an increase in
CXCR3+/
CCR4 + ratio ( from 1.86 to 2.89 , p = 0.0047 ) , whereas there was no change in
CXCR3 + T cells . -
pubmed
These results suggest that short - term oral
corticosteroid modulates the balances of
CXCR3 + and
CCR4 + cells in
patients with
asthma . -
pubmed
The specific properties of the
HER-2 /
neu gene product as a
tumor antigen , and the nature of the immune responses induced by effective preventive treatments are reviewed . -
pubmed
Analysis of 25
Rec NciI alleles in
Gaucher disease patients . -
pubmed
An association between
human immunodeficiency virus type I ( HIV-1 ) protease inhibitors ( PIs ) and
galactorrhoea /
hyperprolactinemia adverse effect has recently been reported in four
HIV-1 - infected women treated with PIs (
indinavir ,
nelfinavir ,
ritonavir or
saquinavir ) . -
pubmed
We then examined the antitumor effect of cationic multilamellar liposome containing
human IFN - beta ( huIFN - beta ) gene (
IAB-1 ) against
RCC . -
pubmed
The
cytotoxicity of
IAB-1 against
human RCC (
NC65 ,
ACHN , and freshly isolated RCC cells ) , prostate and bladder cancer cell lines , and renal proximal tubule endothelial cells (
RPTEC5899 ) was examined by the colorimetric method using
tetrazolium salt . -
pubmed
RESULTS : The
RCC cells treated with
IAB-1 secreted significant amounts of
huIFN - beta protein continuously . -
pubmed
In contrast , treatment with 1000 IU / ml recombinant
huIFN - beta protein resulted in weak
cytotoxicity . -
pubmed
The size of
NC65 tumors transfected with
IAB-1 in
mice was significantly smaller than that receiving injection of empty liposome or recombinant
huIFN - beta protein . -
pubmed
To investigate the role of the A36R : A33R interaction during
viral infection , five recombinant
vaccinia viruses containing
B5R - GFP as a marker were constructed . -
pubmed
ALOPECIA PROBABLY DUE TO A MUCINOUS DEGENERATION OF THE CONNECTIVE TISSUE COMPONENT OF THE HAIR FOLLICLE ? -
pubmed
Mucopolysaccharidosis IVA (
MPS IVA ) is a
lysosomal storage disorder caused by the
deficiency of N - acetylgalactosamine-6 - sulfate sulfatase (
GALNS ) . -
pubmed
Mutation screening of the
GALNS was performed by genomic PCR and direct sequence analyses in 20
MPS IVA patients from Latin America . -
pubmed
There was also no apparent correlation between
wbiI RFLP type and the ability of a single Bcc isolate to infect an individual with
CF . -
pubmed
[ The influence of medicine to the expression of
cell adhesion molecule in experimental otitis media with
effusion ] . -
pubmed
OBJECTIVE : To study the influence of
Cefaclor and
Prednisonum to the expression of
cell adhesion molecule in experimental otitis media with
effusion (
OME ) . -
pubmed
Cefaclor and
Prednisonum may improve otitis media with
effusion , which may related to the decreasing expression of
Mac-1 and
L - Selectin . -
pubmed
An elevated erythrocyte sedimentation rate ,
C - reactive protein , tubular
proteinuria and
renal glucosuria returned to normal 2 weeks after treatment was started . -
pubmed
Selenomethionine prevents degeneration induced by overexpression of wild - type
human alpha - synuclein during differentiation of
neuroblastoma cells . -
pubmed
OBJECTIVE : High levels of wild - type
alpha - synuclein are found in autopsied brain samples of
idiopathic Parkinson ' s disease (
PD ) , some
familial PD , some
Alzheimer ' s disease (
AD ) and
Down ' s syndrome with
dementia . -
pubmed
Bone marrow
mammaglobin expression as a marker of graft - versus - tumor effect after reduced - intensity allografting for advanced
breast cancer . -
pubmed
We assessed
mammaglobin (
MMG ) gene expression in bone marrow ( BM ) aspirates from
patients with advanced
breast cancer who had received a reduced - intensity conditioning and stem cell allografting , in order to detect a graft - versus - tumor effect on
micrometastatic disease . -
pubmed
In one case , a disease response occurring after donor lymphocyte infusion and grade II acute
GVHD was heralded by negativization of
MMG expression . -
pubmed
IDO - expressing antigen - presenting cells are found in
tumor - draining lymph nodes , where they can create a tolerogenic microenvironment . -
pubmed
IDO can also be expressed within the
tumor itself , by tumor cells or host stromal cells , where it can inhibit the effector phase the immune response . -
pubmed
Strategies to inhibit the
IDO pathway may thus assist in breaking tolerance to
tumors , and might enhance the efficacy of other immunotherapy strategies by removing unwanted counter - regulation . -
pubmed
Third - generation
cephalosporins and beta - lactam /
beta - lactamase inhibitor antibacterials as well as
clindamycin or
metronidazole are often required to provide broad - spectrum coverage for
polymicrobial infections . -
pubmed
GM - CSF deficiency reduces macrophage
PPAR - gamma expression and aggravates
atherosclerosis in
ApoE - deficient
mice . -
pubmed
OBJECTIVE :
Granulocyte - macrophage colony - stimulating factor (
GM - CSF ) is expressed in
atherosclerotic lesions but its significance for lesion development is unknown . -
pubmed
Consequently , we investigated the significance of
GM - CSF expression for development of
atherosclerotic lesions in
apolipoprotein E - deficient ( apoE (-/- ) ) mice . -
pubmed
We measured lesion size , macrophage , smooth muscle cell , and
collagen accumulation at the aortic sinus , and expression of genes that regulate
cholesterol transport and
inflammation . -
pubmed
Lesion size in
hyperlipidemic apoE(-/-).
GM - CSF(-/- ) increased by 30 % ( P<0.05 ) , macrophage accumulation doubled , and
collagen content reduced by 15 % ( P<0.05 ) ; smooth muscle cell accumulation and vascularity were unaffected . -
pubmed
CONCLUSIONS :
GM - CSF deficiency increases
atherosclerosis under hypercholesterolemic conditions , indicating antiatherogenic role for
GM - CSF . -
pubmed
We suggest this protective role is mediated by
PPAR - gamma and
ABCA1 , molecules that affect
cholesterol homeostasis and
inflammation . -
pubmed
BACKGROUND & amp ; AIMS : Changes in mitochondrial energy metabolism promoted by
uncoupling proteins ( UCPs ) are often found in
metabolic disorders . -
pubmed
Changes of serum
beta - endorphin by programmed exercise training are correlated with improvement of clinical symptoms and quality of life in female
mitral valve prolapse syndrome . -
pubmed
Losartan preserves integrity of cardiac gap junctions and
PGC-1 alpha gene expression and prevents cellular apoptosis in remote area of left ventricular myocardium following
acute myocardial infarction . -
pubmed
This study tests the hypothesis that
peroxisome proliferator activated receptor - gamma coactivator 1alpha (
PGC-1alpha ) and the integrity of gap junctions ( GJs ) were suppressed and the number of apoptotic bodies was increased in remote viable areas of left ventricle following
acute myocardial infarction (
AMI ) , which can be reversed by
losartan therapy . -
pubmed
The results showed that mRNA expression of
PGC-1alpha , integrated area ( microm(2 ) ) of clustered
connexin43 (
Cx43 ) spots , and
Cx43 GJs were substantially down - regulated and the number of apoptotic bodies was markedly increased in nontreated
AMI rats compared with healthy control and
losartan - treated
AMI rats on day 14 following
AMI ( all values of P & lt ; 0.001 ) . -
pubmed
Down - regulation of GJs and
PGC-1alpha gene expression and cellular death were frequently observed in remote viable areas of LV following
AMI . -
pubmed
Differential role of
gonadotropin - releasing hormone on
human ovarian epithelial cancer cell invasion . -
pubmed
In this study , we examined the effects of
gonadotropin - releasing hormone ( GnRH )- I ( the classical mammalian
GnRH ) ,
GnRH - II ( a second form of
GnRH ) , and
GnRH receptor on invasion using two
human ovarian carcinoma cell lines ,
OVCAR-3 and
SKOV-3 . -
pubmed
In addition , we found that
GnRH - I and
GnRH - II interfered with activation of the
phosphatidylinositol-3 - kinase /
AKT pathway that is well documented to stimulate proteolysis and invasion of
ovarian cancer cells . -
pubmed
Taken together , these observations suggest that
GnRH - I and
GnRH - II play key regulatory roles in ovarian
tumor cell invasion and extracellular matrix degradation . -
pubmed
Management of
asthma in preschool
children with inhaled
corticosteroids and
leukotriene receptor antagonists . -
pubmed
Several recent studies have confirmed the efficacy and safety of both inhaled
corticosteroids and
leukotriene receptor antagonists in the management of early childhood
asthma . -
pubmed
Based on the current body of evidence , there is rationale for further investigation of these management strategies , including direct comparisons between inhaled
corticosteroids and
leukotriene receptor antagonists , as well as the role of long - acting beta - agonists , potentially targeting the subpopulations of early childhood with
wheezing who are at highest risk for persistence of
asthma symptoms . -
pubmed
Elevated expression of
Mcl-1 accompanies the development of various
cancers ,
neurodegenerative disorders and also
infectious diseases . -
pubmed
Ablating expression of this protein may be an attractive therapeutic strategy in the treatment of various
cancers , and the diseases where
Mcl-1 may play a key role in apoptosis supression . -
pubmed
Establishing glycaemic control with continuous subcutaneous
insulin infusion in
children and
adolescents with
type 1 diabetes : experience of the PedPump Study in 17 countries . -
pubmed
Recently investigation shows that cell discrepant response to the overexpression of different IGF-1 isoforms and the E - peptides , and more interestingly ,
IGF-1Ea ,
IGF-1Eb (
MGF ) and
MGF E - peptide have potential to promote skeletal muscle regeneration , to prevent cardiac muscle loss and
neural damage . -
pubmed
Anemia was defined as
hemoglobin & lt;/=13 g / dL ( men ) or & lt;/=12 g / dL ( women ) and/or use of
erythropoietin (
EPO ) . -
pubmed
Anemic patients ( 59.4 % ) had less
sideremia ( 73.4 vs 81.2 microg / dL ; P = .008 ) , but no significant differences were observed for
transferrin saturation index ( 25.9 % vs 25.5 % ) ,
ferritin ( 167 vs 171 ng / mL ) ,
iron insufficiency ( 26.5 % vs 36.2 % ) , pronounced
ferropenia ( 20.4 % vs 20.1 % ) ,
folic acid ( 7.5 vs 6.6 ng / mL ) , or
vitamin B12 ( 486 vs 530 pg / mL ) . -
pubmed
IL-14 alpha , the nexus for primary
Sjogren ' s disease in
mice and
humans . -
pubmed
To evaluate the role of
interleukin 14 alpha (
IL-14a ) in
Sjogren ' s syndrome (
SS ) , we evaluated the expression of
IL-14a in the peripheral blood lymphocytes ( PBL ) of
patients with primary and secondary
SS and normal controls by quantitative RT - PCR . -
pubmed
In addition , transgenic
IL-14a mice were analyzed from 6 weeks of age to death for both histological and immunological features of
Sjogren ' s disease . -
pubmed
Patients with both primary and secondary
Sjogren ' s syndrome expressed
IL-14a at statistically higher levels in their peripheral blood compared to normal controls matched for age , sex and ethnic group . -
pubmed
Transgenic
mice in which
IL-14a expression was increased constitutively were previously demonstrated to develop
hypergammaglobulinemia , autoantibodies , infiltration of the parotid glands with lymphocytes , mild immune - complex mediated
renal disease and large
B cell lymphoma . -
pubmed
Thus
IL-14a is important in the pathophysiology of
Sjogren ' s disease . -
pubmed
The
IL-14a transgenic
mouse is a novel
animal model that can be utilized to understand the pathophysiology of
Sjogren ' s disease . -
pubmed
IGF - IR tyrosine kinase interacts with
NPM -
ALK oncogene to induce survival of T - cell
ALK+
anaplastic large - cell lymphoma cells . -
pubmed
Although it promotes the growth of stimulated hematopoietic cells , a direct role of
IGF - IR in
malignant lymphoma has not been identified . -
pubmed
Approximately 85 % of
ALK(+ )
ALCL cases harbor the translocation t(2;5)(p23;q35 ) , which generates the chimeric oncogene
NPM -
ALK . -
pubmed
In the present study , we explored a possible role of
IGF - IR in
ALK(+ )
ALCL . -
pubmed
Our results demonstrate that
IGF - IR and
IGF - I are widely expressed in
ALK(+ )
ALCL cell lines and primary
tumors . -
pubmed
Antagonism of
IGF - IR decreased the viability , induced apoptosis and cell - cycle arrest , and decreased proliferation and colony formation of
ALK(+ )
ALCL cell lines . -
pubmed
Our findings improve current understanding of the biology of
IGF - IR and
NPM -
ALK and have significant therapeutic implications as they identify
IGF - IR signaling as a potential therapeutic target in
ALK(+ )
ALCL and possibly other types of
malignant lymphoma . -
pubmed
FW was identified in F(2:3 ) families by evaluating seedling leaf symptoms and
vascular tissue damage at plant maturity under natural field infection conditions over 2 years . -
pubmed
A core
MYC gene expression signature is prominent in basal - like
breast cancer but only partially overlaps the core serum response . -
pubmed
BACKGROUND : The
MYC oncogene contributes to induction and growth of many
cancers but the full spectrum of the
MYC transcriptional response remains unclear . -
pubmed
In contrast , comparison to a panel of
breast cancers revealed a strong concordance in gene expression between the Core
MYC Signature and the basal - like breast
tumor subtype , which is a subtype with poor prognosis . -
pubmed
This concordance was supported by the higher average level of
MYC expression in the same
tumor samples . -
pubmed
Phase I dose escalation pharmacokinetic assessment of intravenous humanized anti -
MUC1 antibody AS1402 in
patients with advanced
breast cancer . -
pubmed
Alterations in
MUC1 glycosylation accompany the development of
cancer and influence cellular growth , differentiation , transformation , adhesion , invasion , and immune surveillance . -
pubmed
A
20 - amino - acid tandem repeat that forms the core protein of
MUC1 is overexpressed and aberrantly glycosylated in the majority of
epithelial tumors . -
pubmed
AS1402 is a potent inducer of antibody - dependent cellular cytotoxicity ( ADCC ) , specifically against
MUC1 - expressing
tumor cells . -
pubmed
The objective of this study was to determine the safety , tolerability , and pharmacokinetic ( PK ) characteristics of
AS1402 monotherapy in
patients with locally advanced or metastatic
MUC1 - positive
breast cancer that had progressed after
anthracyclines- and
taxane - based therapy . -
pubmed
Novel
cftr gene sequence variation in Serbian patient with
idiopathic disseminated bronchiectasis . -
pubmed
This paper reports a novel
Cystic Fibrosis Transmembrane Conductance Regulator (
CFTR ) gene variant , 1811 + 1G-->T , detected in a 5 - year - old
girl diagnosed with
idiopathic disseminated bronchiectasis and negative sweat
chloride test ( 17 mmol / L ) . -
pubmed
A novel
NUP98 /
RARG gene fusion in
acute myeloid leukemia resembling
acute promyelocytic leukemia . -
pubmed
The involvement of
RARG in a chimeric fusion transcript has not been reported previously in
human leukemia . -
pubmed
Cognitive deficits in
Down syndrome : narrowing ' Down ' to
Olig1 and
Olig2 . -
pubmed
Human beta defensins ( HBD ) 1 ,
HBD2 , and
HBD3 are key elements of innate immunity that are secreted to neutralize / control the progression of
infection . -
pubmed
RESULTS : In comparison with basal conditions , the secretion profile of
HBD1 remained without significant changes ;
HBD2 level in
CHD and AMN increased 1.9- and 1.4 - times , respectively , after stimulation with
bacteria . -
pubmed
HBD3 secretion level increased significantly ( 7.8 + /- 1.9 pg / micrograms ) in the
CHD but only if the stimulus was applied on the AMN side . -
pubmed
coli , results in a tissue specific secretion of
HBD1 ,
HBD2 , and
HBD3 mainly in the
CHD , which is the first infected region during an
ascending infection . -
pubmed
After whole - body irradiation of repair - proficient and repair - deficient (
DNA - PK - and ATM - deficient )
mice , the formation and rejoining of DSBs was analyzed in SSCs of testis compared with somatic cells of other tissues by enumerating
gammaH2AX- ,
MDC1- , and
53BP1 - foci . -
pubmed
BACKGROUND : The sensitive and accurate detection of
hepatitis B virus surface antigen (
HBsAg ) is critical to the identification of
infection and the prevention of transfusion transmitted disease . -
pubmed
CONCLUSIONS : An improved Abbott ARCHITECT
HBsAg prototype assay with enhanced detection of
HBsAg and
HBsAg mutants , as well as equivalent specificity was developed for the detection , diagnosis , and management of
HBV infection . -
pubmed
CYP2C9 polymorphism in
patients with
epilepsy : genotypic frequency analyzes and
phenytoin adverse reactions correlation . -
pubmed
The distribution of variant
CYP2C9 alleles and prevalence of
phenytoin adverse reactions were hereby investigated in a population of
patients diagnosed with
epilepsy . -
pubmed
METHOD : Allele - specific PCR analysis was carried out in order to determine frequencies of the two most common variant alleles ,
CYP2C9 * 2 and
CYP2C9 * 3 in genomic DNA isolated from 100
epileptic patients . -
pubmed
CONCLUSION : Our findings indicate an overall similar distribution of the
CYP2C9 alleles in a population of
patients diagnosed with
epilepsy in the South of Brazil , compared to other samples . -
pubmed
Myocardial production and release of
MCP-1 and
SDF-1 following
myocardial infarction : differences between
mice and
man . -
pubmed
Stromal derived factor - 1 alpha (
SDF-1a ) and
monocyte chemotactic factor 1(
MCP-1 ) are detectable in peripheral blood after
myocardial infarction (
MI ) . -
pubmed
METHODS :
Murine hearts were studied for expression of
MCP-1 and
SDF-1a at day 3 and day 28 following
myocardial infarction to determine whether production is increased following
MI . -
pubmed
In addition , we studied the coronary artery and coronary sinus ( venous ) blood from
patients with normal coronary arteries , stable
coronary artery disease (
CAD ) ,
unstable angina and
MI to determine whether these
cytokines are released from the heart into the systemic circulation following
MI . -
pubmed
MCP-1 mRNA is upregulated following
murine experimental
MI , but
SDF-1a is suppressed . -
pubmed
There is less release of
SDF-1a into the systemic circulation in
patients with all stages of
CAD including
MI , mimicking the
animal model . -
pubmed
However
MCP-1 release from the
human heart following
MI is also suppressed , which is the exact opposite of the
animal model . -
pubmed
CONCLUSIONS :
SDF-1a and
MCP-1 release from the
human heart are suppressed following
MI . -
pubmed
This review focuses on the diverse role of co - stimulatory molecules of the
B7 and
tumour necrosis factor ( TNF )- superfamily and their downstream signalling effectors in
atherosclerosis . -
pubmed
In particular , the contribution of
CD28 /
CD80 /
CD86 /
CTLA4 ,
ICOS /
ICOSL ,
PD-1 /
PDL-1 / 2 ,
TRAF ,
CD40 /
CD154 ,
OX40 /
OX40L ,
CD137 /
CD137L ,
CD70 /
CD27 ,
GITR /
GITRL , and
LIGHT to
arterial disease is reviewed . -
pubmed
Probe functionality was validated using fluorescence and MR measurements as well as in vitro studies using
cancer cells that overexpress
folate receptors . -
pubmed
METHOD : Hepatic function in the immunological
liver injury model was evaluated by assessing the levels of
ALT in plasma , and the content of
MDA , ORAC ,
NO and
iNOS mRNA in liver tissues . -
pubmed
CONCLUSION : The results indicated that VSE exerted potential effects on immunological
hepatitis and the mechanisms might be partly related to free radical scavenging activity and inhibit release of
iNOS . -
pubmed
Familial childhood gout with
progressive renal impairment attributable to mutations of the
uromodulin (
UMOD ) gene is associated with reduced
uromodulin in the proximal tubule cilia . -
pubmed
Familial juvenile hyperuricemic nephropathy (
FJHN ) is one of three similar clinical disorders associated with
uromodulin gene mutations . -
pubmed
Genetic studies of
urate transportation and of
uromodulin - related
nephropathy emphasize the pivotal importance of the proximal tubule in
uric acid homeostasis . -
pubmed
Initial
PSA & gt;20 ng / mL is generally considered an adverse prognostic feature in
prostate cancer (
PCa ) . -
pubmed
Our goals were to estimate the impact of radical prostatectomy ( RP ) on biochemical recurrence- ( BCR- ) free and
cancer - specific survival ( CSS ) rates of
PCa patients with
PSA & gt;20 ng / mL , and to identify
patients with favorable oncological outcome . -
pubmed
Dyslipidemia , and especially
atherogenic dyslipidemia , a combination of
small low - density lipoproteins cholesterol (
LDL - C ) , decreased
high - density lipoprotein cholesterol (
HDL - C ) and increased
triglyceride ( TG ) concentrations , represents a major cardiovascular ( CV ) risk factor . -
pubmed
Nuclear receptor
peroxisome proliferator - activated receptors (
PPARs ) are involved in the regulation of lipid metabolism ;
PPAR ligands are used to treat
dyslipidemias . -
pubmed
Fibrates target
atherogenic dyslipidemia by increasing plasma HDL - C concentrations and decreasing small dense LDL (
sdLDL ) particles and TGs , thus contributing to
dyslipidemia management , particularly in
patients with
diabetes (
DM ) or the
metabolic syndrome (
MetS ) . -
pubmed
M2a Mp are frequently termed "
wound healing " Mp , as they express factors that are important for tissue repair . -
pubmed
Survivin expression is an independent poor prognostic marker in
lung adenocarcinoma but not in
squamous cell carcinoma . -
pubmed
Survivin is a member of the inhibitors of apoptosis and frequently overexpressed in various
cancer cells . -
pubmed
Overexpression of
survivin in
lung cancer cells attenuates antitumor effect of
tyrosine kinase inhibitors . -
pubmed
However , data from the previous studies on the clinicopathologic implication of
survivin in
non - small - cell lung carcinoma (
NSCLC ) are inconsistent . -
pubmed
We investigated the expression of
survivin in 373 cases of surgically resected
NSCLC . -
pubmed
In
adenocarcinoma , the increased expression of
survivin was associated with the presence of vascular invasion , lymph node metastasis , and
tumor recurrences , but we did n't find any correlation with
survivin expression and clinicopathological parameters in
squamous cell carcinoma . -
pubmed
Patients with high
survivin expression had significantly shorter
disease - free survival ( DFS ; 42.2 vs. 58.8 months ; p = 0.001 ) and shorter overall survival ( OS ; 60.8 vs. 71.5 months ; p = 0.009 ) than those with low
survivin expression group in
adenocarcinoma . -
pubmed
In
squamous cell carcinoma , the expression of
survivin was not associated with prognosis of the
patients ( DFS ; 48.9 vs. 48.7 months ; p = 0.837 , OS ; 61.0 vs. 62.4 months ; p = 0.771 ) . -
pubmed
Multivariate analysis confirmed that
survivin was an independent poor prognostic factor in
adenocarcinoma ( DFS : hazard ratio ( HR ) , 1.687 ; 95 % confidence interval ( CI ) , 1.123 - 2.532 ; p = 0.012 ; OS : HR , 1.965 ; 95 % CI , 1.108 - 3.486 ; p = 0.021 ) . -
pubmed
Our results suggest that
survivin is an independent negative prognostic factor in
adenocarcinoma , but
not in squamous cell carcinoma . -
pubmed
The different prognostic roles played by
survivin in
adenocarcinoma and
squamous cell carcinoma highlights the biological differences between these two histologic types . -
pubmed
Five major
glioblastoma genetic alterations (
epidermal growth factor receptor (
EGFR ) ,
phosphatase and tensin homologue (
PTEN ) ,
Ki-67 ,
O6 - methylguanine - DNA methyltransferase (
MGMT ) and
p53 ) were confirmed by immunohistochemistry and analyzed for correlation with the nTBV of each
tumor . -
pubmed
Ki-67 labeling index indicated significant positive correlation with the nTBV of the
tumor ( p = .01 ) . -
pubmed
7 - Hydroxymitragynine induces a potent antinociceptive effect on
mouse acute
pain through
mu - opioid receptors . -
pubmed
A recombinant hypoallergenic
tropomyosin has been developed , which opens a new avenue in the treatment of
shellfish allergy . -
pubmed
Limited G x E effects were detected between variants in
SLC6A4 and both
panic / agoraphobia and
post - traumatic stress . -
pubmed
In addition , studies in
CKD patients on
angiotensin - converting enzyme inhibitors ,
angiotensin receptor blockers , and/or direct
renin inhibitors have shown that
aldosterone levels paradoxically rise in approximately 30 % to 40 % of
patients on these
renin -
angiotensin system - blocking drugs . -
pubmed
Hence , there is interest in using
mineralocorticoid receptor blockers that directly target the inflammatory and fibrotic effects of
aldosterone in
CKD patients . -
pubmed
A better understanding of
mineralocorticoid receptor blocker pharmacology should help inform future research directions and clinical practice decisions as to how best to use these agents in
CKD . -
pubmed
The biofilm - associated protein (
Bap ) of
Staphylococcus aureus is a high molecular weight cell - wall - anchored protein involved in biofilm formation , first described in bovine
mastitis strains from Spain . -
pubmed
Early onset
ectopia lentis due to a
FBN1 mutation with non - penetrance . -
pubmed
Isolated ectopia lentis is usually autosomal dominant and commonly due to the mutations of
FBN1 gene . -
pubmed
In conclusion , we report on a case of early - onset autosomal dominant
isolated ectopia lentis caused by
FBN1 mutation that has previously been reported only in
Marfan syndrome . -
pubmed
Hepatocyte - Specific Depletion of
UBXD8 Induces Periportal
Steatosis in
Mice Fed a High - Fat Diet . -
pubmed
We showed previously that
UBXD8 plays a key role in proteasomal degradation of lipidated
ApoB in
hepatocarcinoma cell lines . -
pubmed
After 26 wk of a high - fat diet ,
UBXD8 - LKO
mice exhibited
macrovesicular steatosis in the periportal area and microvesicular
steatosis in the perivenular area , whereas control
mice exhibited
steatosis only in the perivenular area . -
pubmed
The results showed that depletion of
UBXD8 in hepatocytes suppresses
VLDL secretion , and could lead to periportal
steatosis when
mice are fed a high - fat diet . -
pubmed
This is the first demonstration that an abnormality in the intracellular
ApoB degradation mechanism can cause
steatosis , and provides a useful model for periportal
steatosis , which occurs in several
human diseases . -
pubmed
Anti -
NMDA receptor encephalitis (
ANRE ) has been previously reported as a rare cause of
nonconvulsive status epilepticus (
NCSE ) . -
pubmed
Maximum
abdominal aortic aneurysm diameter was the only factor that significantly affected the
CD62P values ( p = 0.005 ) . -
pubmed
Postoperative
CD36 values were significantly correlated with total
aneurysm volume ( p = 0.05 ) and were higher in endografts made from
polyester ( p = 0.01 ) . -
pubmed
Non - invasive prenatal detection of
haemoglobin Bart ' s disease by cardiothoracic ratio during the first trimester . -
pubmed
This non - invasive approach for the exclusion of
Hb Bart ' s disease can be used in early pregnancy . -
pubmed
A significant increase of both
IgM and
IgG antibody titres found in paired acute- and convalescent - phase serum confirmed the diagnosis of acute
MSF . -
pubmed
On the other hand , several lines of evidence support a role for
CaSR in promotion of cell differentiation and inhibition of proliferation in
neuroblastoma , a
tumor arising from precursor cells of developing PNS . -
pubmed
Furthermore , only
K562 / HLA + CD80 / 86 + PD - L1 cells pulsed with
HLA - A*24:02 - restricted
Wilms tumor 1 ( WT1 ) peptide clearly expanded
WT1 - specific CTLs from healthy donors . -
pubmed
Surprisingly , the number of
Gal-3 + and CD45 + cells decreased in the SVZ after
cuprizone , suggesting
inflammation was selectively reduced therein . -
pubmed
Inflammation can regulate SVZ proliferation and indeed the number of
phosphohistone H3 + ( PHi3 + ) cells decreased in the SVZ but increased in the CC in both genotypes after
cuprizone treatment . -
pubmed
Therefore ,
ER stress poses a promising target in
colorectal cancers , which develop as a result of Wnt activating mutations . -
pubmed
Here , we report that embryonic myogenic progenitors lacking the
phosphatase and tensin homolog (
Pten ) exhibit enhanced proliferation and differentiation , resulting in
muscle hypertrophy but fewer SCs in adult muscles . -
pubmed
Cytochrome P450 - 2D6 Genotype Definition May Improve Therapy for Paroxysmal
Atrial Fibrillation A Case of
Syncope Following " Pill - in - the - Pocket "
Quinidine plus
Propafenone . -
pubmed
We searched for evidence relating
Cytochrome P450 - 2D6 phenotypes or genotypes to antiarrhythmic metabolism in order to judge whether this analysis might contribute to improved safety and effectiveness of antiarrhythmic medications commonly utilized in the treatment of
atrial fibrillation . -
pubmed
We also describe a
patient in whom knowledge of his IM / PM
CYP2D6 genotype might have prevented the only episode of
syncope and
myocardial stunning which developed during his 28 years of " Pill - in - a - Pocket " therapy . -
pubmed
Loss of maternal chromosome 11 is a signature event in
SDHAF2 ,
SDHD , and
VHL - related paragangliomas , but less significant in
SDHB - related paragangliomas . -
pubmed
Germline mutations in the
succinate dehydrogenase (
SDHA ,
SDHB ,
SDHC ,
SDHD ,
SDHAF2 ) or
Von Hippel - Lindau (
VHL ) genes cause
hereditary paraganglioma /
pheochromocytoma . -
pubmed
While
SDHB ( 1p36 ) and
VHL ( 3p25 ) are associated with
autosomal dominant disease ,
SDHD ( 11q23 ) and
SDHAF2 ( 11q13 ) show a remarkable parent - of - origin effect whereby
tumor formation is almost completely dependent on paternal transmission of the mutant allele . -
pubmed
Using fluorescent in situ hybridization , microsatellite marker and SNP array analysis , we demonstrate that loss of the entire copy of chromosome 11 is also frequent in
SDHAF2 - related
PGLs , occurring in 89 % of
tumors . -
pubmed
By contrast , both copies of chromosome 11 were found to be retained in 62 % of
SDHB - mutated
PGLs /
PCCs , while only 31 % showed loss of maternal chromosome 11p15 . -
pubmed
Genome - wide copy number analysis revealed frequent loss of 1p in
SDHB mutant
tumors and show greater genomic instability compared to
SDHD and
SDHAF2.These results show that loss of the entire copy of maternal chromosome 11 is a highly specific and statistically significant event in
SDHAF2 ,
SDHD and
VHL - related PGLs /
PCCs , but is less significant in
SDHB - mutated
tumors , suggesting that these
tumors have a distinct genetic etiology . -
pubmed
Fecal
Calprotectin in
Cystic Fibrosis and Its Relation to Disease Parameters : A Longitudinal Analysis for 12 Years . -
pubmed
OBJECTIVES : Fecal
calprotectin (
FC ) is a marker of
inflammation in the intestinal tract . -
pubmed
We assessed
FC levels longitudinally in
patients with
cystic fibrosis (
CF ) and evaluated the relation between FC results and relevant markers of disease . -
pubmed
Pancreatic insufficiency ( ie , fecal
elastase & lt;100 mug / g stool ) was associated with considerably higher FC values compared to normal pancreatic function ( median FC 68 vs 29 mug / g , P & lt ; 0.0001 ) . -
pubmed
APOE epsilon4 status is associated with
white matter hyperintensities volume accumulation rate independent of
AD diagnosis . -
pubmed
To assess the relationship between carriage of
APOE epsilon4 allele and evolution of
white matter hyperintensities (
WMHs ) volume , we longitudinally studied 339 subjects from the
Alzheimer ' s Disease Neuroimaging Initiative cohort with diagnoses ranging from normal controls to probable
Alzheimer ' s disease (
AD ) . -
pubmed
Following adjustment for
APOE status , these differences became nonstatistically significant suggesting that
APOE epsilon4 genotype is the major driver of accumulation of WMH volume rather than diagnosis of
AD . -
pubmed
The density of mast cells
c - Kit+ and
tryptase+ correlates with each other and with angiogenesis in
pancreatic cancer patients . -
pubmed
Nevertheless , few data are available concerning the role of MCs positive to
tryptase in primary
pancreatic cancer angiogenesis . -
pubmed
This study analyzed the correlation between mast cells positive to
c - Kit receptor (
c - Kit+ MCs ) , the density of MCs expressing
tryptase (
MCD - T ) and microvascular density ( MVD ) in primary
tumor tissue from
patients affected by
pancreatic ductal adenocarcinoma (
PDAC ) . -
pubmed
Tumor tissue samples were evaluated by mean of immunohistochemistry and image analysis methods in terms of number of
c - Kit+ MCs ,
MCD - T and
MVD . -
pubmed
Our in vivo preliminary data , suggest that
tumor microenvironmental MCs evaluated in terms of
c - Kit+ MCs and
MCD - T may play a role in
PDAC angiogenesis and they could be further evaluated as a novel
tumor biomarker and as a target of anti - angiogenic therapy . -
pubmed
In this regard , glial cells express
cannabinoid receptors and synthesize
endocannabinoids , and cannabinoid drugs affect some functions of these cells that can be implicated in
schizophrenia pathobiology . -
pubmed
Predictive Value of
CD4+/
CD8 + Ratio in Patients with
Breast Cancer Receiving Recombinant
Human Thrombopoietin . -
pubmed
Recombinant
human thrombopoietin (
rhTPO ) is a key determinant of therapy for chemotherapy - induced
thrombocytopenia (
CIT ) in
patients with
breast cancer . -
pubmed
To assess the predictive value of preoperative inflammatory cells for response to
rhTPO in
breast cancer patients , a total of 198 female
patients with
breast cancer were enrolled between June 2011 and December 2016 in Liaoning Cancer Hospital . -
pubmed
Among 83
patients with grade 2
CIT , plasma
CD4+/
CD8 + ratio was lower significantly in
rhTPO responders than in
rhTPO nonresponders ( 1.19 + - 0.47 vs. 2.22 + - 1.11 , P & lt ; 0.05 ) with 83 % accuracy , but we observed little significant differences in
patients with grade 3/4
CIT ( 1.32 + - 0.51 vs. 2.25 + - 0.77 , P & lt ; 0.05 ) with 76 % accuracy . -
pubmed
We conclude that pretreatment
CD4+/
CD8 + ratio is a convenient , easily measured predictive indicator for
patients with
breast cancer receiving
rhTPO , especially in
patients with grade 2
CIT . -
pubmed
Acetyl - CoA promotes
glioblastoma cell adhesion and migration through
Ca2 + -
NFAT signaling . -
pubmed
Genes involved in
integrin signaling and cell adhesion were identified as
acetyl - CoA - responsive in
glioblastoma cells , and we demonstrate that
ATP citrate lyase (
ACLY)-dependent
acetyl - CoA production promotes cell migration and adhesion to the extracellular matrix . -
pubmed
Presepsin : A new marker of catheter related
blood stream infections in pediatric patients : Reply to Rivera - Moran Javier et al . -
pubmed
Currently , mutations in the
kisspeptin system ,
MKRN3 , and
DLK1 have been identified in sporadic and familial cases of
CPP . -
pubmed
Activation of
CB1R in the PVN induces
hyperphagia by modulating directly or indirectly orexigenic and anorexigenic signals ; however , interaction among these mediators has not been clearly defined . -
pubmed
Some GABAergic terminals are negatively influenced by
5 - HT , suggesting that the
hyperphagic effect of
CB1R activation could involve changes in serotonergic and GABAergic signaling in the PVN . -
pubmed
Accordingly , the present study was aimed to characterize the neurochemical mechanisms related to the
hyperphagic effects induced by activation of
CB1R in the PVN , studying in vitro and in vivo changes induced by direct activation these receptors . -
pubmed
aeruginosa
skin infection in a
mouse model , and
PlyPa91 protected
mice in a
lung infection model , making these lysins potential drug candidates for Gram - negative
bacterial infections of the skin or respiratory mucosa . -
pubmed
SBF2 - AS1 : An oncogenic lncRNA in
small - cell lung cancer . -
pubmed
The long noncoding RNAs ( lncRNAs )
SBF2 antisense RNA 1 (
SBF2 - AS1 ) was found to act as an oncogenic lncRNA in
non - small - cell lung cancer (
NSCLC ) , but the role of
SBF2 -
AS1 in
small - cell lung cancer (
SCLC ) was still unclear . -
pubmed
The purpose of this study was to provide the clinical significance and biological function of
SBF2 -
AS1 in
SCLC . -
pubmed
In our results ,
SBF2 -
AS1 was found to be upregulated in
SCLC tissues compared with
NSCLC tissues or adjacent
normal lung tissues . -
pubmed
Besides ,
SBF2 -
AS1 expression was also elevated in
SCLC cell lines compared with the
normal bronchial epithelial cell line or
NSCLC lines . -
pubmed
Moreover , high expression of
SBF2 -
AS1 was associated with clinical stage ,
tumor size , lymph node metastasis and distant metastasis in
SCLC patients . -
pubmed
Survival analysis showed
SCLC patients with high expression of
SBF2 -
AS1 had shorter overall survival than
patients with low expression of
SBF2 - AS1 , and high expression of
SBF2 -
AS1 acted as an independent poor prognostic factor for overall survival in
SCLC patients . -
pubmed
The study in vitro suggested inhibition of
SBF2 -
AS1 obviously depressed cell proliferation , migration , and invasion in
SCLC . -
pubmed
In conclusion ,
SBF2 -
AS1 acts as a novel oncogenic lncRNA in
SCLC . -
pubmed
Polymorphisms in
Adipokines in Mexican Children with
Obesity . -
pubmed
We propose to investigate the contribution of adipokines and
cytokines polymorphisms and common BMI /
obesity - associated loci , revealed in genome - wide association studies in Caucasian adult cohorts , with childhood
obesity . -
pubmed
Only both
TMEM18 ( rs6548238 ; rs7561317 ) polymorphisms were found associated with
obesity ( OR=0.5 , P=0.008 ) and were in linkage disequilibrium ( r2=0.87 ) . -
pubmed
The linear regression showed that the rs7561317 polymorphism of
TMEM18 is negatively associated with
obesity . -
pubmed
This report highlights the influence of
TMEM18 in Mexican - Mestizo children
obesity , while adipokine and
cytokine polymorphisms were not associated with it . -
pubmed
High expression of
CXCL14 is a biomarker of
lung adenocarcinoma with micropapillary pattern . -
pubmed
We extracted differentially expressed genes with high expression levels in
MPP samples , and chose
VSIG1 ,
CXCL14 and
BAMBI as candidate biomarkers for
MPP . -
pubmed
RT - qPCR analysis confirmed a significantly higher expression of
VSIG1 ( P=0.03 ) and
CXCL14 ( P=0.02 ) in
MPP than others . -
pubmed
In validation set of 4
MPP and 4
non - MPP samples ,
CXCL14 expression was validated to be significantly higher in
MPP than in non - MPP ( P=0.04 ) . -
pubmed
Comparing a total of 10
MPP and 20
non - MPP samples , the AUC of
CXCL14 to distinguish
MPP from others was 0.89 . -
pubmed
In immunostaining of
CXCL14 , the staining score was significantly higher in
MPP cases than others , where not only
MPP component but also other components showed heterogeneous staining in
adenocarcinoma tissues with
MPP . -
pubmed
Moreover , higher staining score of
CXCL14 significantly associated with poorer prognosis , in all
patients ( P=0.01 ) or within cases at stage I - III ( P=0.01).In summary , we identified
CXCL14 as a possible diagnostic biomarker of
MPP . -
pubmed
While immunotherapies and targeted therapies such as
BRAF inhibitors have improved the prognosis ,
BM is still associated with poor outcome and a short survival . -
pubmed
All consecutive
patients treated between May 2014 and December 2017 for a newly diagnosed locally advanced or metastatic
melanoma with available status for
BRAF mutation were identified . -
pubmed
Of interest , another mechanistic approach responds to considering the inhibition of the
renin -
angiotensin -
aldosterone system ( RAAS ) , which is exacerbated in
COVID-19 infection because the virus binds to the enzyme
ACE2 , making more
angiotensinII available to cause damage . -
pubmed
Several
cancer - related pathways were enriched , including the
TGF - beta pathway , the focal adhesion pathway , and the
JAK -
STAT signaling pathway , and 20 prognostic ceRNA regulatory networks were subsequently identified . -
pubmed
Here , we discuss how host genetic variation may influence
cytokine responses to
respiratory viral infections and , based on our current understanding of the role that
cytokines play in viral pathogenesis , how this may influence disease severity . -
pubmed
We hypothesized that
HMGA1 is important in the function of mesenchymal stromal cells ( MSCs ) , which are known to modulate inflammatory responses due to
sepsis . -
pubmed
Taken together , these data demonstrate that expression of
dnHMGA1 in MSCs provides a functional advantage of the cells when administered during
bacterial sepsis . -
pubmed
Emodin enhances
cisplatin sensitivity in
non - small cell lung cancer through
Pgp downregulation . -
pubmed
PKA - RIIbeta autophosphorylation modulates
PKA activity and
seizure phenotypes in
mice . -
pubmed
Dysfunctional
PKA signaling is causally linked to the
TLE . -
pubmed
In the present study , we found the autophosphorylation level at
serine 114 site (
serine 112 site in
mice ) of
PKA - RIIbeta subunit was robustly decreased in the
epileptic foci obtained from both surgical specimens of
TLE patients and
seizure model
mice . -
pubmed
Notably , by using a P - site mutant that can not be autophosphorylated and thus results in the released catalytic subunit to exert persistent phosphorylation , an increase in
PKA activities through transduction with AAV -
RIIbeta - S112A in hippocampal DG granule cells decreased mIPSC frequency but not mEPSC , enhanced neuronal intrinsic excitability and
seizure susceptibility . -
pubmed
In contrast , a reduction of
PKA activities by
RIIbeta knockout led to an increased mIPSC frequency , a reduction in neuronal excitability , and
mice less prone to experimental
seizure onset . -
pubmed
Collectively , our data demonstrated that the autophosphorylation of
RIIbeta subunit plays a critical role in controlling neuronal and network excitabilities by regulating the activities of
PKA , providing a potential therapeutic target for
TLE . -
pubmed
[
Alpha 1 antitrypsin in
pulmonary fibrosis in
children ] . -
pubmed
Evidence is reviewed that
5 - HT (
5 - hydroxytryptamine ,
serotonin ) acting through the
5 - HT3 receptor subtype can influence behaviour relevant to
anxiety ,
schizophrenia and
cognitive disorders , and that
5 - HT3 receptor antagonists such as
ondansetron (
CAS 116002 - 70 - 1 ) can correct behavioural disturbance in the absence of effect on normal behaviour . -
pubmed
The
5 - HT3 receptor antagonists exert a breadth of action over a wide dose range in
rodent and
primate models to inhibit aversive behaviour in
animal models of
anxiety and certain symptoms of withdrawal from drugs of abuse ,
alcohol ,
nicotine ,
diazepam and
cocaine , to antagonise increased locomotor activity caused by mesolimbic
dopamine excess , and facilitate performance in cognitive tests . -
pubmed
The studies reveal an important role for
5 - HT3 receptors in the regulation of limbic - cortical functioning , and a critical role for
5 - HT3 receptor antagonists to establish the role of
5 - HT3 receptors in
schizophrenia ,
anxiety , drug withdrawal phenomena and
cognitive disturbance . -
pubmed
In the active stage of
UC , mucosal
spermidine concentration was higher than in remission or in the controls , but the activities of
ornithine decarboxylase and
S - adenosylmethionine decarboxylase , rate - limiting enzymes of
polyamine biosynthesis , were lower . -
pubmed
In the active stage of
UC , the mucosal level of mRNA coding for
ornithine decarboxylase was lower than in the remission stage of
UC or in the controls . -
pubmed
The activity of
spermidine / spermine N1 - acetyltransferase , the rate - limiting enzyme of
polyamine degradation , was higher in the active stage of
UC than in the remission stage of
UC or in the controls . -
pubmed
To analyze the proliferative capacity of CD4 + or
CD8 + T - cell subsets of individuals infected with
human immunodeficiency virus type 1 (
HIV-1 ) and to optimize the in vitro conditions for virus replication , CD4 + or CD8 + cells of
HIV-1 - infected patients were selectively activated inside the whole peripheral blood mononuclear cell ( PMNC ) population by dual antibody stimulation . -
pubmed
Ex vivo perfusion of
rat kidneys with the endothelium binding lectin
concanavalin A (
con A ) followed by
rabbit anti
con A IgG results in a subendothelial IC
nephritis in glomerular capillaries ( GC ) and diffuse IC formation with complement (
C3 ) deposition in peritubular capillaries ( PC ) . -
pubmed
The mapping of the deletion breakpoint within the DP cluster allows the orientation of the loci in the
DP region with respect to the centromere as follows : centromere ,
DP beta 2 ,
DP beta 1 ,
DP alpha 1 , ( DQ , DR ) . -
pubmed
Results of the " Tandem - E CKMB " immunoenzymometric procedure ( y ) for
creatine kinase (
CK ;
EC 2.9.3.2 ) were compared with electrophoresis ( x ) for 160 serum samples from
patients suspected of having sustained
myocardial infarctions . -
pubmed
Hepatotoxicity was judged by plasma
alanine aminotransferase and
aspartate aminotransferase levels , hepatic
cytochrome P-450 content , and liver histology . -
pubmed
This differential response between resistant and susceptible
mouse lines further supports an important role for
ACF in the stepwise progression of
colon cancer . -
pubmed
BACKGROUND :
Glutaminase , the principal enzyme of
glutamine hydrolysis , breaks down
glutamine to supply energy and intermediates for cell growth and is present in high concentrations in replicating tissues such as intestinal epithelium and
malignant tumors . -
pubmed
In the host with
cancer ,
glutaminase activity in the gut mucosa diminishes as the
tumor grows , but the regulation of this response is unknown . -
pubmed
Because
cytokines may regulate the altered
glutamine metabolism that is characteristic of the host with
cancer , we studied the effects of
cytokines on gut mucosal
glutaminase expression in vitro using the
human enterocytic Caco-2 cell line . -
pubmed
CONCLUSIONS : This
IFN - gamma - mediated decrease in
glutaminase activity may be one mechanism by which gut
glutamine metabolism is diminished as the
tumor grows and becomes the principal organ of
glutamine use . -
pubmed
Immunological detection of membrane - associated
human luteinizing hormone correlates with gene expression in cultured
human cancer and fetal cells . -
pubmed
We have demonstrated the expression of membrane - associated
hCG and its subunits and fragments by cells from 78
human cancer cell lines of different types and origins , indicating that such expression is a common phenotypic characteristic of cultured
human malignant cells . -
pubmed
Because
human ( h )
LH beta has 80 % homology with
hCG beta and is coded by one of the seven genes in the gene cluster located in chromosome 19 , it was important to determine whether
hLH and its beta - subunit are also expressed as membrane - associated proteins by cells from
human cancer cell lines . -
pubmed
Thus , 11
cancer cell lines of different types and origins were adapted to grow in serumless medium , with Nutridoma - HU or SP as serum substitute , and analyzed by flow cytometry using two monoclonal antibodies directed to different conformational epitopes of intact
hLH and a monoclonal antibody reacting with an epitope of
hLH beta - free . -
pubmed
Determination of translatable levels of
hLH beta and
hCG beta messenger RNAs ( mRNAs ) was performed in cells from some of the
cancer cell lines , including the
JEG-3 choriocarcinoma cell line , and in cells from a
human fetal lung cell line . -
pubmed
These findings were corroborated by the presence of translatable levels of
hLH beta and
hCG beta mRNAs in all of the
cancer cell lines analyzed , indicating that the expression of these membrane - associated glycoproteins is a phenotypic characteristic of
human cancer cells and that the activation of the
hCG beta - hLH beta gene cluster is nonselective . -
pubmed
The presence of translatable levels of
hCG beta - hLH beta mRNAs in the cultured
human fetal lung cells punctuates once more the in vivo and in vitro biochemical similarities between fetal and
cancer cells . -
pubmed
Association of
ACE gene polymorphisms with
coronary artery disease in a northern area of Japan . -
pubmed
The insertion / deletion DNA polymorphism of the gene coding
human angiotensin converting enzyme (
ACE ) was examined in 109
patients with
coronary artery disease (
CAD ) and 93 non - coronary subjects ( NCS ) living in a northern part of Japan . -
pubmed
Young
MI showed similar frequencies in
ACE gene polymorphisms to those in
NCS , a pattern which differed from that seen in subjects with
CAD ( p & lt ; 0.05 ) . -
pubmed
The numbers of risk factors did not alter the frequency of
ACE gene genotype among patients with
CAD , however , in normotensives , the odds ratio of
DD - genotype was significantly increased to 3.4 . -
pubmed
Accordingly ,
ACE gene polymorphism may be associated with morbidity from
CAD in Japanese living in northern Japan as has been noted in Caucasians , despite the lower frequencies of the D - allele in the Japanese population . -
pubmed
The results indicate a genetic effect on sensitivity to humoral immune response modulation by uremic status , with deficient antibody production despite a normal T cell proliferative response to
mitogen stimulation in short - duration
renal failure in high responder
mice . -
pubmed
Increased methylation can deplete DA , NE , and
5 - HT ; increase
acetylcholine ; and cause
hypokinesia and
tremors . -
pubmed
In order to clarify the significance of
p16 gene (
CDKN2 ) inactivation and its disease specificity among
hematopoietic tumors , configurations of the
p16 gene as well as those of the adjacent
p15 and interferon alpha ( IFN alpha ) genes were examined in primary
hematopoietic tumors . -
pubmed
Loss of the
p16 gene is frequent in and highly specific to
lymphoid tumors among
hematopoietic tumors . -
pubmed
Gene deletions but not minute mutations should be the predominant mechanism of
p16 gene inactivation in these types of
tumors . -
pubmed
Deletions of the
p16 gene were frequently observed in
tumors carrying
chromosome 9p abnormalities while a significant number of cases showed loss of the
p16 gene without chromosome 9p abnormalities . -
pubmed
So far inactivation of
p53 and
Rb tumor suppressors have also been found in
lymphoid tumors . -
pubmed
In our study , we detected homozygous deletions of
p16 gene in 20 % , loss of
Rb protein in 28 % , and
p53 gene alterations in 8 % of
lymphoid tumors . -
pubmed
Reduction in
transforming growth factor - beta type II receptor in
mouse lung carcinogenesis . -
pubmed
Loss of growth inhibition by
TGF - beta is thought to contribute to the development of many types of
tumors . -
pubmed
To examine the roles of
TGF - beta1 , - beta2 , and - beta3 and
TGF - beta RI and
RII in chemically induced
mouse lung tumorigenesis , we used immunohistochemical and in situ hybridization analyses to measure the expression of their proteins and mRNAs in A / J
mice treated with the carcinogen
urethane to induce
lung adenomas . -
pubmed
Immunostaining for the
TGF - beta ligands and receptors was also detected in
adenomas by 2 mo . -
pubmed
While immunostaining for
TGF - beta1 , - beta2 , and - beta3 and
TGF - beta RI in
adenomas was detected at levels comparable to those in bronchioles , immunostaining for
TGF - beta RII was less intense in
adenomas than in bronchioles . -
pubmed
Decreased immunostaining for
TGF - beta RII in
adenomas persisted for at least 8 mo after exposure to
urethane , whereas immunostaining for
TGF - beta1 , - beta2 , and - beta3 and
TGF - beta RI persisted at levels comparable to those in normal bronchioles . -
pubmed
In situ hybridization studies conducted with
TGF - beta receptor riboprobes showed a corresponding reduction in expression of
TGF - beta RII mRNA but not of
TGF - beta RI mRNA in
adenomas compared with expression in bronchioles . -
pubmed
Expression of
TGF - beta RII mRNA was also examined in non - tumorigenic and tumorigenic
mouse lung cells ; expression of
TGF - beta RII mRNA was lower in the tumorigenic cells derived from
urethane - induced
lung tumors . -
pubmed
Therefore the interaction between the hypothalamic stress hormone
corticotropin releasing factor (
CRF ) and
SP was investigated in
AtT20 / D16v - cells , a cellular model derived from a
pituitary tumor . -
pubmed
Serum and peritoneal fluid levels of
IGF I and II and
insulinlike growth binding protein-3 in
endometriosis . -
pubmed
OBJECTIVE : To examine whether
insulinlike growth factor I (
IGF I ) ,
IGF II and
IGF binding protein 3 (
IGFBP 3 ) in serum and peritoneal fluid ( PF ) correlate with the presence and severity of
endometriosis . -
pubmed
CONCLUSION :
IGF I may be an important mediator in the development and/or maintenance of
endometriosis or progression to late - stage disease . -
pubmed
Although it is clear that additional studies are required to design strategies for the improvement of the immunogenicity of
CF proteins , our observations support the currently accepted view that secreted protein - based preparations may represent promising vaccine candidates for
TB . -
pubmed
Cytoplasmic localization of the
interferon - inducible protein that is encoded by the
AIM2 ( absent in
melanoma ) gene from the 200 - gene family . -
pubmed
The
HGPS hens had significantly higher percentages of blood lymphocytes and
CD4+:
CD8 + ratios of circulating T cells ( P & lt ; 0.01 ) and tended to have more , but not significantly , gammadelta T cells ( P = 0.07 ) than the LGPS hens . -
pubmed
The concentrations of plasma
IgG were also significantly higher in the
LGPS hens ( P & lt ; 0.01 ) . -
pubmed
Biochemical defects in
11 - cis - retinol dehydrogenase mutants associated with
fundus albipunctatus . -
pubmed
Mutations in the gene encoding
11 - cis - retinol dehydrogenase (
RDH5 ; EC ) are associated with
fundus albipunctatus , an
autosomal recessive eye disease characterized by stationary
night blindness and accumulation of white spots in the retina . -
pubmed
The numbers of identified
RDH5 mutations linked to
fundus albipunctatus have increased considerably during recent years . -
pubmed
Ganglioside GD1a inhibits
HGF - induced motility and scattering of
cancer cells through suppression of tyrosine phosphorylation of
c - Met . -
pubmed
HepG2 cells , a
human hepatoma cell line , were used to investigate whether
GD1a interferes with other cancer cells expressing
c - Met . -
pubmed
These results suggest that
GD1a acts as a negative regulator of
c - Met in
cancer cells . -
pubmed
Soluble
TNF receptor fusion protein ( etanercept ) for the treatment of
myelodysplastic syndrome : a pilot study . -
pubmed
Blockade of
tumor necrosis factor ( TNF ) alpha by a soluble
TNF receptor fusion protein ( etanercept ;
Enbrel ) improved in vitro hemopoiesis from the marrow of
patients with
myelodysplastic syndrome (
MDS ) . -
pubmed
BACKGROUND : Invasive
adenocarcinomas developing in the
rat dorsolateral prostate on combined treatment with
3,2 '- dimethyl-4 - aminobiphenyl (
DMAB ) and
testosterone propionate (
TP ) are biologically
androgen - independent and lacking
androgen receptor protein (
AR ) expression . -
pubmed
The present study was conducted to assess the mechanisms underlying this loss of
AR expression in
rat prostate cancer . -
pubmed
METHODS : The methylation status of the
AR gene promoter region in
rat prostate cancer and cell lines (
PLS10 , 20 , and 30 ) was examined by Southern blotting , methylation - specific polymerase chain reaction , and methylation - sensitive single - strand conformation analysis ( MS - SSCA ) . -
pubmed
RESULTS :
AR mRNA expression was not detected in any of the
rat prostate cancers or
cancer cell lines tested by Northern blot analysis . -
pubmed
The CpGs suggested to be responsible for
AR expression in
rat prostate cancer were found to be located -9 and -1 nucleotides upstream of the transcriptional initiation site . -
pubmed
CONCLUSIONS : These data clearly demonstrate that aberrant hypermethylation in the
AR promoter region may play a critical role in
AR expression in
rat prostate cancers . -
pubmed
Inducible
nitric oxide synthase expression in the ischemic core and penumbra after transient focal
cerebral ischemia in
mice . -
pubmed
The present observations examined the hypothesis that the
iNOS expression in the ischemic penumbra after a transient focal ischemic insult is involved in the recruitment of penumbra into
infarction . -
pubmed
The time course of
iNOS protein , enzymatic activity and
NO concentration in the penumbra but not in the core matched the process of
infarct maturation . -
pubmed
at 6 and 12 h after reperfusion inhibited
iNOS activity by 88.0 + /- 10.4 % and reduced
NO concentration by 48.5 + /- 8.3 % in the penumbra , and lessened
infarct size by 48.8 + /- 7.2 % . -
pubmed
These results suggest that
iNOS expression in the ischemic penumbra is involved in the recruitment of penumbra into
infarction and thereby contributing to the enlargement of
infarct . -
pubmed
Adrenalectomy stimulates hypothalamic
proopiomelanocortin expression but does not correct diet - induced
obesity . -
pubmed
BACKGROUND : Elevated glucocorticoid production and reduced hypothalamic
POMC mRNA can cause
obese phenotypes . -
pubmed
Conversely , adrenalectomy can reverse
obese phenotypes caused by the absence of
leptin , a model in which glucocorticoid production is elevated . -
pubmed
We hypothesized that adrenalectomy would increase hypothalamic
POMC mRNA and reverse
obese phenotypes in
obesity due to a high - fat diet as it does in
obesity due to
leptin deficiency . -
pubmed
The high - fat diet increased body weight , adiposity , and plasma
leptin , led to
impaired glucose tolerance , and slightly stimulated hypothalamic
proopiomelanocortin ( POMC ) expression . -
pubmed
CONCLUSION : These data suggest that neither reduction of plasma glucocorticoid levels nor elevation of hypothalamic
POMC expression is effective to significantly reverse diet - induced
obesity . -
pubmed
The purpose of this study was to determine the frequency and type of
HPV associated with
vulvar SK (
VSK ) and to compare expression of biomarkers (
p16 ,
Mib-1 , and
cyclin E ) in these lesions . -
pubmed
Increased
Mib-1 staining was significantly more common in
VSKs than in other vulvar
lesions , but not in
CSKs ; increased
p16 and
cyclin E staining was not more common . -
pubmed
Unlike the cervix ,
p16 and
cyclin E will not consistently distinguish VSKs from
HPV - negative lesions due to underexpression in low - risk
HPV infections ( p16 ) and less - restricted expression in vulvar
lesions (
cyclin E ) . -
pubmed
Circulating
endothelin (
ET ) levels are elevated in
heart failure and positively correlated with severity of
heart failure . -
pubmed
Recent studies demonstrated
arginine vasopressin ( AVP ) V2 mRNA expression was upregulated in the inner medullary collecting duct ( IMCD ) of
cardiomyopathic hamsters ( CM ) . -
pubmed
The goal of the present studies was to determine if
ET-1 is involved in upregulating the expression of
AVP V2 mRNA in the IMCD of
CM by using a mixed
ETA / ETB receptor antagonist
bosentan . -
pubmed
Our results showed plasma
ET-1 levels increased in CM
hamsters and related with the severity of
heart failure . -
pubmed
The effect of
bosentan in normalizing the expression of
AVP V2 and
AQP2 mRNA in the IMCD of
CM was confirmed by in situ hybridization studies . -
pubmed
This study demonstrated that
AVP V2 and
AQP2 mRNA are upregulated in CM
hamsters and these upregulations are attenuated by
bosentan treatment , suggesting that
ET-1 plays a role in upregulating the expression of
AVP V2 mRNA in
CM hamsters . -
pubmed
[ Evaluation of
CA72 - 4 as a
tumor marker in
patients with
gastric cancer ] . -
pubmed
The clinical efficacy of CA72 - 4 for
gastric cancer was studied in comparison with
CEA and
CA19 - 9 . -
pubmed
However , the positive rates of
CEA and
CA72 - 4 were significant higher in the cases with lymph node metastasis and curative grade B , C. The combination assay of
CEA and
CA72 - 4 was valuable because the
tumor markers were considered to be independent of each other . -
pubmed
In conclusion ,
CA72 - 4 is more important than
CA19 - 9 as a
tumor marker in
gastric cancer patients . -
pubmed
Here we show that
mice lacking the endolysosomal
aspartic proteinase cathepsin E spontaneously develop
skin lesions similar to those of
humans with
AD when reared under conventional conditions but not under specific pathogen - free conditions . -
pubmed
These results strongly suggest that the development of
AD in
cathepsin E - deficient
mice is initiated by systemic accumulation of
IL-18 and
IL-1beta , mainly due to their reduced turnover rates . -
pubmed
In addition , the reduced expression of
cathepsin E was also observed in erythrocytes of both
humans with
AD and the
AD mouse model NC / Nga . -
pubmed
Cathepsin E deficiency might thus be responsible for the induction of
AD in
humans and
mice . -
pubmed
Aberrant methylation and histone deacetylation associated with silencing of
SLC5A8 in
gastric cancer . -
pubmed
Aberrant methylation of a
sodium co - transporter ,
solute carrier family 5 member 8 gene (
SLC5A8 ) , has been detected in a subset of
colorectal cancers , suggesting
SLC5A8 may also serve as a
tumor suppressor . -
pubmed
To further investigate the role of epigenetic inactivation of
SLC5A8 expression in
gastric cancer , we determined the methylation status of the
SLC5A8 5 ' CpG island ( CGI ) in a panel of
gastric cancer cell lines and primary
gastric cancers . -
pubmed
We detected methylation of the 5'CGI in ten of twelve
gastric cancer cell lines , and five of those showed dense methylation , which correlated with the absence of
SLC5A8 transcription . -
pubmed
Aberrant methylation of
SLC5A8 was also detected in 23 of 71 ( 30 % ) primary
gastric cancers , indicating that epigenetic inactivation of
SLC5A8 is not a cell - line - specific phenomenon . -
pubmed
It thus appears that aberrant methylation of its 5'CGI and histone deacetylation play key roles in silencing
SLC5A8 expression in
gastric cancers . -
pubmed
Depression of classic complement pathway components and high titers of anti - DNA , anti - nucleosome , or anti -
Clq antibodies identify patients are increased risk of renal involvement or flares of
nephritis . -
pubmed
Mechanisms of adaptations for
oxytocin neurones are reviewed , using challenge with systemic
interleukin-1beta , simulating activation of immune signaling by
infection , as a stressor of special relevance in pregnancy . -
pubmed
Interleukin 1beta-511 C / T polymorphism and risk of
aneurysmal subarachnoid haemorrhage . -
pubmed
The
p53 tumor suppressor protein is a DNA sequence - specific transcriptional regulator that , in response to various forms of cellular stress , controls the expression of numerous genes involved in cellular outcomes including among others , cell cycle arrest and cell death . -
pubmed
Accuracy of
epidermal growth factor receptor mutation analysis on the basis of small biopsy specimens in
patients with
nonsmall cell lung cancer . -
pubmed
Effect of physical training on ventricular repolarization in
type 1 long QT syndrome : a pilot study in asymptomatic carriers of the G589D
KCNQ1 mutation . -
pubmed
We hypothesized that controlled submaximal endurance training would not adversely affect ventricular repolarization in asymptomatic carriers of a
KCNQ1 gene mutation of
type 1 long QT syndrome (
LQT1 ) . -
pubmed
CONCLUSION : In this pilot study of asymptomatic carriers of a
KNCQ1 gene mutation , submaximal endurance training did not harmfully affect
arrhythmia risk markers . -
pubmed
Evolution of
HCV infection is determined by the intensity of immune response , type of secreted
cytokines and persistence of specific
HCV T lymphocytes response . -
pubmed
The omega3 - depleted
rats also displayed
liver steatosis , increased incorporation of long - chain polyunsaturated
omega6 fatty acids in liver phospholipids and increased activity of liver
Delta9 - desaturase . -
pubmed
In particular , approaches such as
hypoxia - conditionally replicating viruses , cellular vehicles , and gene therapy means to disrupt the
hypoxia - inducible factor (
HIF ) signaling are outlined . -
pubmed
Immunohistochemical analysis of
glucose transporter-1 showed positive in endometrial tissue and negative in
leiomyoma . -
pubmed
Using these vignettes , we evaluated statistical associations linking a decision to increase the glucocorticoid dose to the value of PMR - AS , of its components ( VASph , visual analog scale for
pain [ VASp ] ,
C - reactive protein level [
CRP ] , morning stiffness [ MST ] , and elevation of upper limbs [ EUL ] ) , or to the difference in these variables between the last 2 visits ( dPMR - AS , dVASph , dVASp , dCRP , dMST , and dEUL ) . -
pubmed
Are
beta - lactams related to higher morbidity and mortality in
urinary tract infections caused by extended - spectrum
beta - lactamase - producing
Escherichia coli ? -
pubmed
Vitamin E supplementation enhances
hemoglobin and
erythropoietin levels in mildly
anemic adults . -
pubmed
Efficacy of
acetyl - cholinesterase - inhibitor ( ACHEI ) treatment in
Alzheimer ' s disease : a 21 - month follow - up " real world " study . -
pubmed
Long - term efficacy of
acetyl - cholinesterase - inhibitor ( ACHEI ) treatment in mild - to - moderate
Alzheimer ' s disease (
AD ) is of great relevance for clinical routine and has been investigated over a 21 - month period of treatment in a " real word " population . -
pubmed
Remarkably , most of the genes were linked to
FOS in an early
hypoxia pathway . -
pubmed
The gene expression of
FOS also increased with longer exposure to
hypoxia . -
pubmed
We have shown that
FOS - related genes , which have been implicated in early
hypoxia as well as the development of
breast cancers , were differentially expressed before and after surgery . -
pubmed
Inflammation and
tumor progression : a lesson from
TNF - alpha - dependent
FAK signaling in
cholangiocarcinoma . -
pubmed
We have shown that
FAK plays a critical role in
MMP-9 production and subsequent invasion of the
cholangiocarcinoma activated by an inflammatory
cytokine ,
TNF - alpha . -
pubmed
As degradation of the ECM is a prerequisite step for the invasion and metastasis of
cancer cells , we used an assay of gelatin - degrading
MMPs by Zymography to clarify the characteristic feature of the matrix degrading systems of the
cancer cells . -
pubmed
Immunoprecipitation and western blot analysis together with site specific phosphorylated
FAK antibodies showed aberrant
FAK activity in inflammation - mediated
tumor cells . -
pubmed
We demonstrated the effectiveness of
FAK siRNA treatment to prevent
tumor invasion . -
pubmed
Our observations suggested the importance of
FAK as a therapeutic target for
malignant neoplasm . -
pubmed
Comparison of hand - carried ultrasound assessment of the inferior vena cava and
N - terminal pro - brain natriuretic peptide for predicting readmission after hospitalization for acute decompensated
heart failure . -
pubmed
OBJECTIVES : We sought to compare the value of serial assessment with hand - carried ultrasound ( HCU ) of the inferior vena cava ( IVC ) with
brain natriuretic peptide (
BNP ) to identify
patients with
acute decompensated heart failure (
ADHF ) who will be readmitted or seek emergency department treatment after hospital discharge . -
pubmed
In this study , we developed an adenovirus for conditional replication in
p53 - dysfunctional
tumor cells that uses
p53 - selective expression of a microRNA - network directed against essential adenoviral genes . -
pubmed
Compared to a control virus that expressed a scrambled microRNA - network , antiviral RNAi selectively attenuated viral replication in cells with transcriptionally active
p53 , but not in
p53 - dysfunctional
tumor cells where both viruses replicated equivalently . -
pubmed
Since these results were confirmed by an in vivo comparison of both viruses after
infection of
p53 - knockout and normal
mice , we could demonstrate that attenuated replication was indeed a result of
p53 - selective exhibition of antiviral RNAi . -
pubmed
Addressing the therapeutic applicability , we could show that the application of RNAi - controlled virus efficiently lysed
p53 - dysfunctional
tumors in vitro and in vivo but resulted in drastically reduced load of virus - DNA in the liver of treated
mice . -
pubmed
We have generated a broadly applicable adenovirus for selective destruction of
p53 - dysfunctional
tumors and thereby demonstrate that virus - encoded RNAi - networks represent an efficient and versatile tool to modify viral functions . -
pubmed
Alzheimer ' s disease is characterised by regional
neuronal degeneration ,
synaptic loss , and the progressive deposition of the 4 kDa
beta - amyloid peptide (
Abeta ) in senile plaques and accumulation of
tau protein as neurofibrillary tangles . -
pubmed
Disturbances of
APP processing and/ or synthesis in oligodendrocytes may account for some
myelin disorders observed in
Alzheimer ' s disease and other
senile dementias . -
pubmed
Here we modelled the
synapse damage that occurs in
prion diseases by measuring the amount of
synaptophysin , a pre - synaptic membrane protein essential for neurotransmission , in cortical or hippocampal neurones incubated with the disease associated isoform of the
prion protein (
PrP(Sc ) ) , or with the prion - derived peptide PrP82 - 146 . -
pubmed
The addition of
PrP(Sc ) or
PrP82 - 146 caused a dose - dependent reduction in the
synaptophysin content of
PrP wildtype neurones indicative of
synapse damage . -
pubmed
Promoter
histone H3 lysine 9 di - methylation is associated with DNA methylation and aberrant expression of
p16 in
gastric cancer cells . -
pubmed
p16 , a well - known
tumor suppressor gene , is frequently silenced in DNA hypermethylation manner in
gastric cancer . -
pubmed
Accordingly , we chose
p16 to clarify whether there is a correlation among
histone H3 lysine 9 ( H3 - K9 ) di - methylation ,
H3 - K9 acetylation , DNA methylation and
p16 expression in human
gastric cancer . -
pubmed
These results suggest that
H3 - K9 di - methylation ,
H3 - K9 acetylation and DNA methylation work in combination to silence
p16 in
gastric cancer . -
pubmed
[
Orexin - A in hepatic reperfusion - induced
liver injury in
rats ] . -
pubmed
OBJECTIVE : To explore the change of
orexin - A expression in hepatic reperfusion and their association with
liver injury , and to find out the role of
orexin - A in traumatic stress responses . -
pubmed
There was significant and positive linear correlation between the plasma
orexin - A and serum
glucose and total anti - oxidation capacity ; serum
alanine transaminase in each reperfusion group was significantly higher , and
liver damage was significantly alleviated at the later phase of the
injury . -
pubmed
CONCLUSION :
Orexin - A undergoes significant changes during hepatic reperfusion , indicating that
orexin - A participates in the modulation of hepatic reperfusion - induced
liver injury and
internal disorders . -
pubmed
CONCLUSION : The
JNK2 protein appears to have an essential role in desiccation - induced
corneal epithelial disease by stimulating production of
MMP-1 ,
MMP-9 , and cornified envelope precursors . -
pubmed
Clinical Relevance The
JNK2 protein could be a novel therapeutic target in
dry eye disease . -
pubmed
Mannose - binding lectin and
ficolin-2 gene polymorphisms predispose to
cytomegalovirus ( re ) infection after orthotopic liver transplantation . -
pubmed
METHODS :
OLT patients ( n = 295 ) were genotyped for recipient and donor SNPs in
mannose - binding lectin (
MBL2 ) ,
Ficolin-2 (
FCN2 ) and
MBL - associated serine protease (
MASP2 ) genes . -
pubmed
RESULTS : Combined analysis of independently associated variant
MBL2 [ HR 1.65 , p<0.02 ] and wild - type
FCN2 [ 1.85 ; p<0.02 ] SNPs in the donor liver showed an increased risk of
CMV infection for either and both risk genotypes [ HR 2.02 and HR 3.26 , respectively , p = 0.004 ] , especially in
CMV Donor-/Recipient+ ( D-/R+ ) patients [ HR 4.7 and HR 10.0 , respectively , p = 0.01 ] . -
pubmed
Multivariate Cox analysis showed a consistent stepwise increase in
CMV infection risk with the gene profile of the donor [ up to HR 2.77 ; p<0.005 ] and the combined
MBL2 and
FCN2 donor - recipient mismatch profile [ up to HR 4.57 ; p<0.001 ] , independent from donor - recipient
CMV serostatus , also at higher
CMV ( re)
infection cut - off values . -
pubmed
CONCLUSIONS :
MBL2 and
FCN2 risk alleles of donor liver and recipient constitute independent risk factors for
CMV infection after OLT . -
pubmed
To investigate alterations in neurologic morphology and test the hypothesis that developmental
Pb neurotoxicity is partially mediated through alterations in neuronal growth and transport function of axons , the changes of specific axon tracts in the embryonic
zebrafish brain were observed with anti - acetylated
alpha - tubulin staining at several developmental time points through 36hours post fertilization ( hpf ) . -
pubmed
An overexpression of
netrin2 at these two developmental stages suggests a novel role for this gene in regulating axonal density specific to
Pb neurotoxicity . -
pubmed
We have analysed the effects of both risk factors on
p53 induction during
HBV infection in
HepaRG , a cell line with hepatocyte - like morphology that metabolizes
AFB(1 ) and supports
HBV infection . -
pubmed
Conversely ,
HBV infection did not significantly modify
AFB ( 1 )-DNA adduct formation or repair as assessed by immunodot - blot assay , and the induction of
p53 in response to
AFB ( 1 ) was similar in infected and non - infected HepaRG cells . -
pubmed
Alzheimer ' s disease is characterized by the deposition of aggregates of the
beta - amyloid peptide (
Abeta ) in the brain . -
pubmed
A potential therapeutic strategy for
Alzheimer ' s disease is the use of synthetic beta - sheet breaker peptides , which are capable of binding
Abeta but unable to become part of a beta - sheet structure , thus inhibiting the peptide aggregation . -
pubmed
Augmented
TLR2 expression on monocytes in both
human Kawasaki disease and a
mouse model of
coronary arteritis . -
pubmed
METHODS : Recruited subjects fulfilled the criteria of
KD and were admitted for intravenous
gamma globulin (
IVIG ) treatment at the Kaohsiung Chang Gung Memorial Hospital from 2001 to 2009 . -
pubmed
RESULTS : Both
human KD patients and LCWE - treated
mice developed
coronary arteritis ,
myocarditis ,
valvulitis , and
pericarditis , as well as elevated plasma levels of
interleukin ( IL )- 2 ,
IL-6 ,
IL-10 ,
monocyte chemoattractant protein ( MCP )- 1 , and
tumor necrosis factor ( TNF )- alpha in acute phase . -
pubmed
Toll - like receptor ( TLR )- 2 , but not
TLR4 surface enhancement on circulating CD14 + monocytes , was augmented in
KD patients before IVIG treatment and in LCWE - treated
mice , which declined in
patients after IVIG treatment . -
pubmed
CONCLUSION : This result suggests that that not only
TLR2 augmentation on CD14 + monocytes might be an inflammatory marker for both
human KD patients and LCWE - induced
CAL mouse model but also this model is feasible for studying therapeutic strategies of
coronary arteritis in
human KD by modulating
TLR2 - mediated immune activation on CD14 + monocytes . -
pubmed
Chronic high
glucose ( HG ) inflicts
glucotoxicity on vulnerable cell types such as pancreatic beta cells and contributes to
insulin resistance and impaired
insulin secretion in
diabetic patients . -
pubmed
In this meta - analysis , we determined the prevalence of
MPNs and their subtypes as well as
JAK2V617F and its diagnostic role in these uncommon disorders . -
pubmed
Prevalence of
MPNs ,
JAK2V617F , and
MPN subtypes were calculated using a random - effects model . -
pubmed
In BCS , mean prevalence of
MPNs and
JAK2V617F was 40.9 % ( 95 % CI , 32.9%-49.5 % ) and 41.1 % ( 95 % CI , 32.3%-50.6 % ) , respectively . -
pubmed
In
PVT , mean prevalence of
MPNs and
JAK2V617F was 31.5 % ( 95 % CI , 25.1%-38.8 % ) and 27.7 % ( 95 % CI , 20.8%-35.8 % ) , respectively . -
pubmed
JAK2V617F and
MPNs were more frequent in BCS compared with
PVT ( P = .03 and P = .09 , respectively ) . -
pubmed
JAK2V617F screening in
splanchnic vein thrombosis (
SVT ) patients without typical hematologic MPN features identified
MPN in 17.1 % and 15.4 % of screened
BCS and
PVT patients , respectively . -
pubmed
These results demonstrate a high prevalence of
MPNs and
JAK2V617F in
SVT patients and show differences in underlying etiology between these disorders . -
pubmed
Furthermore , these results validate routine inclusion of
JAK2V617F in the diagnostic workup of
SVT patients . -
pubmed
Elevated serum
endostatin levels is associated with favorable outcome in
acute myeloid leukemia . -
pubmed
The levels and the prognostic relevance of serum
endostatin in
AML patient is not fully clear . -
pubmed
AIM : To evaluate serum levels of
endostatin in
acute myeloid leukemia patients before chemotherapy and after achieving complete remission and to correlate
endostatin levels with
patients outcome . -
pubmed
RESULTS :
Endostatin serum levels were not significantly different in the pretreatment
AML patients as compared to that in normal controls ( P>0.05 ) . -
pubmed
In
AML patients the baseline
endostatin levels were significantly lower than at CR ( P=0.001 ) . -
pubmed
The prognostic value of
sE was also evaluated by dividing
AML patients into high and low sE groups using the 75 percentile sE levels of the
patients group as cutoff . -
pubmed
CONCLUSIONS : Elevated
endostatin levels at
AML diagnosis is a good prognostic marker for
patients ' outcome . -
pubmed
The impact of the receptor of hyaluronan - mediated motility (
RHAMM ) on
human urothelial transitional cell cancer of the bladder . -
pubmed
mRNA - expression levels of
HA synthases (
HAS1 - 3 ) and
HA - receptors (
RHAMM and
CD44 ) were evaluated by real time RT - PCR in comparison to
healthy bladder tissue as control . -
pubmed
In vitro knock - down of
RHAMM ,
CD44 and
HAS isoenzymes was achieved by siRNA and lentiviral shRNA in
J82 bladder cancer cells . -
pubmed
J82 cells after knock - down of
RHAMM were xenografted into male
nu / nu athymic mice to monitor
tumor progression in vivo . -
pubmed
RESULTS : In invasive
tumor stages
RHAMM- ,
HAS1 and
HAS2 mRNA - expression levels were elevated whereas
HAS3v1 was reduced as compared to non - invasive
tumors . -
pubmed
Subsequently , Kaplan - Meier analysis revealed reduced
bladder cancer specific survival in
patients with high
RHAMM mRNA and low
HAS3v1 expression . -
pubmed
Elevated
RHAMM in invasive
tumors was confirmed by
RHAMM immunohistochemistry . -
pubmed
Lentiviral RHAMM knock - down revealed reduced
J82 cell proliferation in vitro and reduced xenograft
tumor growth in vivo . -
pubmed
CONCLUSION : The data suggest that
RHAMM plays a crucial role in mediating progression of
muscle - invasive bladder cancer and recommends
RHAMM for further evaluation as a prognostic marker or therapeutic target in
bladder cancer therapy . -
pubmed
The laboratory diagnosis of
dengue fever was based on the serological detection of
IgM and
IgG antibodies , detection of
dengue NS1 antigen by enzyme - linked immunosobent assay ( ELISA ) , and detection of
dengue virus DNA by RT - PCR . -
pubmed
Typical laboratory findings were
leukocytopenia and
thrombocytopenia , a low
CRP level , and elevated
aminotransferase activity . -
pubmed
In the diagnosis of
acute dengue fever , preference should be given to highly sensitive and specific tests for the direct detection of
dengue virus (
NS1 antigen and RT - PCR assays ) . -
pubmed
We investigated , for the first time , the effects of
alpha - thujone or
beta - thujone administrated centrally on the fear /
anxiety behaviour of 3 - day - old
chicks in an Open Field and their modulation on the
GABAA receptor . -
pubmed
The recombinant
human granulocyte colony - stimulating factor (
rhG - CSF ) is widely used for the treatment of
granulopenia in
humans . -
pubmed
Data suggest that peripheral and spinal
CaCC , and particularly
anoctamin-1 , participates in the acute nociception induced by
formalin as well as in the development and maintenance of secondary mechanical
allodynia and
hyperalgesia . -
pubmed
Time - Dependent
Thrombus Resolution After
Tissue - Type Plasminogen Activator in
Patients With
Stroke and
Mice . -
pubmed
BACKGROUND AND PURPOSE : We investigated the relationship between the degree of
thrombus resolution and the time from
stroke onset or
thrombus formation to intravenous
tissue - type plasminogen activator (
tPA ) treatment . -
pubmed
METHODS : In
patients with
stroke , we measured
thrombus volume on thin - section noncontrast brain computed tomographic scans taken at baseline and 1 hour after
tPA administration . -
pubmed
We determined the association between the time from symptom onset to
tPA treatment and the degree of
thrombus resolution . -
pubmed
In a C57 / BL6
mouse model of
FeCl3 - induced
carotid artery thrombosis , we investigated the effect of
tPA administered at different time intervals after
thrombus formation , using Doppler - based blood flow measurement . -
pubmed
Thrombus was resolved by & gt;=50 % in 43
patients ( 25.1 % , good volume reduction ) and by & lt;50 % in 94
patients ( 55.0 % , moderate volume reduction ) 1 hour after
tPA treatment . -
pubmed
In the
mouse model , as the interval between
thrombus formation and
tPA treatment increased , the initiation of recanalization was delayed ( P=0.006 ) and the frequency of final recanalization decreased ( P for trends=0.006 ) . -
pubmed
CONCLUSIONS : Early administration of
tPA after
stroke onset is associated with better
thrombus resolution . -
pubmed
The most differentially expressed
AT transcript when comparing non - pregnant and pregnant women corresponded to the
IGF binding protein ( IGFBP )- 5 , the expression levels of which was found by subsequent quantitative real - time PCR to be lower in women with
GDM vs women with
NGT ( p & lt ; 0.0001 ) . -
pubmed
The induction of adipose tissue
IGFBP5 in pregnancy and its decrease in
GDM point to the importance of the IGF-1 signalling pathway in
AT expansion in pregnancy and
GDM susceptibility . -
pubmed
When present , the severity of
periodontitis and its relationship with gender , smoking , age ,
corticosteroids dose and
AR activity were assessed . -
pubmed
No relationship between the severity of
periodontitis and
AR activity was found . -
pubmed
BACKGROUND AND OBJECTIVES :
Patients with severe
influenza virus infection ,
multi - organ failure and organ replacement therapy may absorb and metabolize
neuraminidase inhibitors differently . -
pubmed
In blood samples , hypermethylated
ALX4 ,
FBN2 ,
HLTF ,
P16 ,
TMEFF1 and
VIM were associated with poor prognosis , hypermethylated
APC ,
NEUROG1 ,
RASSF1A ,
RASSF2A ,
SDC2 ,
SEPT9 ,
TAC1 and
THBD were detected in
early stage CRC and hypermethylated
P16 and
TFPI2 were associated with
CRC recurrence . -
pubmed
In stool samples , hypermethylated
BMP3 ,
PHACTR3 ,
SFRP2 ,
SPG20 ,
TFPI2 and
TMEFF2 were associated with
early stage CRC . -
pubmed
Selective expression of mutant
huntingtin during development recapitulates characteristic features of
Huntington ' s disease . -
pubmed
Genome - wide gene - based analysis suggests an association between
Neuroligin 1 (
NLGN1 ) and
post - traumatic stress disorder . -
pubmed
We applied gene - based testing to GWAS data from the Grady Trauma Project ( GTP ) , a primarily African American cohort , and identified two genes (
NLGN1 and
ZNRD1 - AS1 ) that associate with
PTSD after multiple test correction . -
pubmed
Although the top SNP from
NLGN1 did not replicate , we observed gene - based replication of
NLGN1 with
PTSD in the Drakenstein Child Health Study ( DCHS ) cohort from Cape Town . -
pubmed
NLGN1 has previously been associated with
autism , and it encodes
neuroligin 1 , a protein involved in synaptogenesis , learning , and memory . -
pubmed
These findings support a contribution of the
NLGN1 gene pathway to the neurobiological underpinnings of
PTSD . -
pubmed
The present study was aimed to investigate the role of
curcumin in
myocardial infarction (
MI ) and its potential mechanism involving
transcription factor specific protein 1 (
SP1 ) . -
pubmed
In vitro experiments ,
mouse cardiac myocytes ( MCM ) subjected to
hypoxia after the incubation of
curcumin , miR-7a / b and
SP1 expression levels were detected by real - time PCR and western blot . -
pubmed
CONCLUSION :
Curcumin pre - treatment protected against
hypoxia - induced cardiac myocytes apoptosis through the up - regulation of miR-7a / b and the down - regulation of
SP1 expression . -
pubmed
Cyr61 and
YB-1 are novel interacting partners of
uPAR and elevate the malignancy of triple - negative
breast cancer . -
pubmed
TNBC lacks established targets for
breast cancer therapy , such as the
estrogen receptor (
ER ) ,
progesterone receptor (
PR ) and the
human epidermal growth factor receptor 2 (
HER2 ) . -
pubmed
TNBC and respective cell lines often overexpress proteins of the
urokinase plasminogen activator system (
uPAS ) including
uPA , its receptor
uPAR and inhibitor
PAI-1 , which together with co - factors contribute to the malignancy of
TNBC . -
pubmed
Here , two novel interacting partners of
uPAR , the
cysteine - rich angiogenic inducer 61 (
Cyr61 ) and the
Y - box - binding protein 1 (
YB-1 ) were identified and their differential expression demonstrated in
TNBC cells as well as in
tumors . -
pubmed
In the
TNBC cohort , both interactors significantly correlated with expression levels of
cathepsin B ,
c - Met and the
tumor grade . -
pubmed
The interactions of
uPAR with
Cyr61 significantly correlated with expression levels of
tumor - promoting biomarkers including
plasminogen ( p=0.0014 ) ,
cathepsin B ( p=0.032 ) ,
c - Met ( p=0.0192 ) as well as with the
tumor grade ( p=0.02 ) . -
pubmed
As the novel interacting partners , also together with
uPAR , contribute to
tumor progression and metastasis , both may be potential therapeutic targets in
breast cancer . -
pubmed
A blinded , randomized , placebo - controlled , dose determination trial of
lokivetmab (
ZTS-00103289 ) , a caninized , anti -
canine IL-31 monoclonal antibody in client owned
dogs with
atopic dermatitis . -
pubmed
Lokivetmab , a caninized anti -
canine IL-31 monoclonal antibody , reduced
pruritus and associated
inflammatory skin lesions in a proof - of - concept study in
dogs with
AD . -
pubmed
Acetylcholinesterase (
AChE ) , which is implicated in the pathophysiology of
neurological disorders , is distributed along the axon and enriched at the presynaptic basal lamina . -
pubmed
Aberrant
AChE activity and ectopic axonal accumulation of the enzyme are associated with
neurodegenerative disorders , such as
Alzheimer ' s disease . -
pubmed
Correlation of
Tissue Transglutaminase with Modified Marsh Grading in
Celiac Disease : A Prospective Cohort Study . -
pubmed
OBJECTIVE : To find out correlation between serum anti -
tissue transglutaminase immunoglobulin - A (
tTGA ) levels and Marsh grading on duodenal histopathology in
Celiac disease (
CD ) . -
pubmed
CONCLUSIONS : Serum
tTGA levels can be used to predict
villous atrophy and biopsy may be avoided in strongly suspected cases with more than 9 times of cut - offs . -
pubmed
Myoepithelial
carcinoma with
RB1 mutation : remarkable chemosensitivity to
carcinoma of unknown origin therapy . -
pubmed
Exome sequencing revealed an inactivating mutation in
RB1 which we believe to be the first such mutation to be reported in this
cancer type . -
pubmed
CONCLUSIONS : Given increasing evidence suggesting
RB1 loss is associated with responsiveness to conventional chemotherapies , particularly
platinum - based regimens , we hypothesize that this genetic feature predisposed chemosensitivity in our
patient 's
tumor . -
pubmed
PCSK9 inhibition and
atherosclerotic cardiovascular disease prevention : does reality match the hype ? -
pubmed
Within this review we look at whether the potential provided by
proprotein convertase subtilisin / kexin type 9 (
PCSK9 ) inhibition for prevention of
atherosclerotic cardiovascular disease matches the excitement generated . -
pubmed
RESULTS : Two
patients had high titers of anti -
CASPR2 (
contactin - associated protein - like 2 ) Abs in serum and CSF and fulfilled the diagnostic criteria of definite
limbic encephalitis . -
pubmed
DESIGN : Genetic , nutritional and anthropometric parameters were measured in 213
dyslipidemic (
LDL & gt;=115 mg / dL ) and 58 normolipidemic (
LDL<115 ) postmenopausal
women . -
pubmed
The majority of patients in both & gt;=50 and & lt;50 age groups received a non -
nucleoside reverse transcriptase inhibitor - based regimen ( 89 % vs. 87 % ) , did not have
AIDS at baseline ( 63 % vs. 62 % ) , and were male ( 59 % vs. 58 % ) . -
pubmed
MAIN RESULTS AND THE ROLE OF CHANCE :
Women with latent
GTB were younger ( 29.8 + - 4.4 years vs. 30.8 + - 4.5 years ; P = 0.003 ) and , following adjustment for age , had significantly lower
AMH [ Median ( IQR ): 2 ( 0.9 , 4.1 ) ng / ml vs 2.8 ( 1.3 , 5 ) ng / ml ; P = 0.01 ] and AFC [ Median ( IQR ): 7 ( 5 , 11 ) vs 8 ( 5 , 14 ) ; P & lt ; 0.001 ] . -
pubmed
In normoxia ,
VHL suppresses
HIF1a - mediated transcriptional response , which is characteristic to
hypoxia . -
pubmed
We showed that even without
hypoxia ,
VHL inactivation leads to hypermethylation of the genome . -
pubmed
We extracted 696 differentially expressed genes relative to a reported
PC signature from the TCGA dataset ( n = 492 ) and built a 15 - gene signature (
SigMuc1NW ) using Elastic - net with 10 - fold cross - validation through analyzing their expressions at 1.5 standard deviation / SD below and 2 SD above a population mean . -
pubmed
SigMuc1NW discriminates
BCR with time - dependent AUC ( tAUC ) values of 76.6 % at 11.5 months ( 76.6%-11.5 m ) , 73.8%-22.3 m , 78.5%-32.1 m , and 76.4%-48.4 m. SigMuc1NW is correlated with adverse features of
PC , high Gleason scores ( odds ratio / OR 1.48 , P & lt ; 2e-16 ) , and advanced
tumor stages ( OR 1.33 , P = 4.37e-13 ) . -
pubmed
SigMuc1NW remains an independent risk factor of BCR ( HR 2.44 , 95 % CI 1.53 - 3.87 , P = 1.62e-4 ) after adjusting for age at diagnosis , Gleason score , surgical margin , and
tumor stage . -
pubmed
Importantly , a 10 - gene subsignature SigMuc1NW1 predicts
BCR in
MSKCC ( P = 3.11e-15 ) and TCGA ( P = 3.13e-12 ) ; SigMuc1NW1 discriminates
BCR at 18.4 m with tAUC as 82.5 % . -
pubmed
Collectively , our analyses support
SigMuc1NW as a novel and robust signature in predicting
BCR of
PC . -
pubmed
The present study aims to investigate whether
ONO-5046 , a novel
neutrophil elastase inhibitor , could affect NETs formation and promote
inflammation resolution . -
pubmed
CONCLUSIONS : The
neutrophil elastase inhibitor
ONO-5046 suppresses ROS - associated NETs formation , which may lead to
inflammation resolution . -
pubmed
Lysine - specific demethylase 1 (
LSD1 ) has been reported to connect with a range of
solid tumors . -
pubmed
Thus , the exploration of
LSD1 inhibitors has emerged as an effective strategy for
cancer treatment . -
pubmed
Conclusions : Compared to cells from healthy donors , sprout formation was more efficiently abrogated in HMVECs from
diabetic patients by blocking
matrix metalloproteinase activity . -
pubmed
Background :
Chimeric antigen receptors (
CARs ) represent a novel facet of modern day synthetic biology that exemplifies personalized medicine at work through their ability to harness and redirect a patient 's immune system to fight
cancer . -
pubmed
Body : By combining the target - specificity of antibodies to the effector capabilities of T cells ,
CARs have yielded high remission rates for many late staged and relapsed / refractory ( r / r )
hematological malignancies , including
acute lymphoblastic leukemias (
ALL ) and
Non - Hodgkin ' s lymphomas . -
pubmed
Amitriptyline attenuates
bleomycin - induced
pulmonary fibrosis : modulation of the expression of
NF - kappabeta ,
iNOS , and
Nrf2 . -
pubmed
Lung injury was evaluated through the histological examination and immunohistochemical detection of
alpha - smooth muscle actin (
alpha - SMA ) in lung tissue , in addition to the biochemical assessment of pulmonary contents of
hydroxyproline and
transforming growth factor beta-1 (
TGF - beta1 ) . -
pubmed
Amitriptyline not only prevents the
depression and its drawbacks in
patients suffering from
pulmonary fibrosis but also it can suppress
fibrosis through variable mechanisms mainly via inhibition of
NF - kappabeta / TNF - alpha /
TGF - beta pathway in addition to inhibition of
Nrf2 and
iNOS expression . -
pubmed
lusitaniae strain for the expression of full - length
FKS1 alleles harbouring known mutations contributing to reduced susceptibility or resistance to
caspofungin , thus opening the way for the screening of other
FKS1 /
FKS2 mutations potentially involved in
RES . -
pubmed
Discordance of high
PD - L1 expression in primary and metastatic
urothelial carcinoma lesions . -
pubmed
Immune checkpoint inhibitors ( ICI ) targeting
PD -( L ) 1 are effective in select
patients with advanced
urothelial carcinoma (
UC ) . -
pubmed
High
PD - L1 expression enriches for response to ICIs ; however , the predictive value of
PD - L1 expression is limited , which may be due in part to dynamic expression of
PD - L1 in the
tumor environment . -
pubmed
We sought to characterize
PD - L1 expression in primary
UC and paired metastatic
lesions to gain insight into the potential discordance of
tumor PD - L1 expression during the metastatic process . -
pubmed
MATERIALS AND METHODS : Immunohistochemical staining for
PD - L1 using the
SP-142 antibody was performed on primary
tumors and matched metastatic specimens in 77 evaluable
subjects with advanced
UC . -
pubmed
Correlation of
PD - L1 expression in
TCs and ICs was estimated using Spearman 's correlation coefficients ( rho , rho ) . -
pubmed
RESULTS : High ( & gt;=5 % )
PD - L1 expression in primary and metastatic biopsies , respectively , was observed in 6.0 % and 7.7 % of
TCs and in 14.5 % and 11.5 % of ICs . -
pubmed
IC
PD - L1 expression in primary
tumors was not correlated with IC
PD - L1 expression in paired metastatic
lesions ( rho = 0.05 , P = 0.67 ) and there was poor agreement in high expression rates between primary and metastatic
lesions in the IC compartment ( kappa= 0.086 ) . -
pubmed
CONCLUSION : High
PD - L1 IC expression is temporally and spatially discordant between primary and metastatic
UC lesions . -
pubmed
Future studies of
PD -( L ) 1 targeted therapies in
patients with metastatic
UC may benefit from use of fresh biopsies of metastatic
lesions to define
PD - L1 expression when feasible . -
pubmed
Cyclin - dependent kinase 7 inhibitor
THZ2 inhibits the growth of
human gastric cancer in vitro and in vivo . -
pubmed
In this study , we analyzed TCGA data and found that upregulation of
CDK7 frequently occurred in
human gastric cancer . -
pubmed
A potent and selective irreversible
CDK7 inhibitor
THZ2 was able to induce cell growth inhibition , cell cycle arrest at G2 / M phase and apoptosis with the increasing intracellular reactive oxidative species ( ROS ) levels in
gastric cancer cells . -
pubmed
Overall , our data showed that inhibition of
CDK7 with
THZ2 in
gastric cancer presented outstanding anticancer effect in vitro and in vivo , suggesting that
CDK7 is a potential therapeutic target for
gastric cancer patients . -
pubmed
Rab7 delays
intervertebral disc degeneration through the inhibition of the
p38MAPK pathway . -
pubmed
The objective of this study is to determine whether
Rab7 could delay
intervertebral disc degeneration and study the mechanism . -
pubmed
We chose old
mice to established
intervertebral disc degeneration model and study the effect of
Rab7 on intervertebral disc by western blotting , quantitative real - time PCR , immunohistochemistry et al . -
pubmed
With the aging of
mice , the degree of
intervertebral disc degeneration was aggravated and the expression of
Rab7 was decreased . -
pubmed
In addition , overexpression of
Rab7 can reduce the
degeneration of nucleus pulposus cells and reduce the levels of
p38 and p -
p38 . -
pubmed
Rab7 is a protective factor for intervertebral discs and could delays
intervertebral disc degeneration through the inhibition of the
p38MAPK pathway . -
pubmed
AAV9 - Mediated
Cdk5 Inhibitory Peptide Reduces Hyperphosphorylated
Tau and
Inflammation and Ameliorates Behavioral Changes Caused by Overexpression of
p25 in the Brain . -
pubmed
Unlike
Cdk5 /
p35 , which is important for brain development , aberrant activity of
Cdk5 /
p25 plays a pathological role in
neurodegenerative diseases , such as
Alzheimer ' s disease , by inducing hyperphosphorylation of downstream substrates related to pathological progression . -
pubmed
OBJECTIVE : First , we aimed to establish a
p25 overexpression adult
mouse model , then to evaluate whether CIP delivered by adeno - associated virus serotype 9 ( AAV9 ) can ameliorate
neuronal toxicity induced by
p25 . -
pubmed
In addition , a significant
learning decline and
anxiety - like behavior were induced by
p25 toxicity , and
CIP treatment improved learning ability in
p25 mice . -
pubmed
CONCLUSION :
AAV - mediated
p25 overexpression
mouse model is easy to construct to study
p25 - induced
neuronal toxicity . -
pubmed
Application of
CIP after
p25 insult reverses the pathological changes and
behavioral abnormalities . -
pubmed
Overall , our results illustrated that JG caused apoptosis and autophagy via activating the ROS - mediated
p53 pathway in
human liver cancer cells in vitro and in vivo , which provided basic scientific evidence that JG serves as a potential anti - cancer agent . -
pubmed
The Family of
Chloride Channel Regulator , Calcium - activated Proteins in the Feline Respiratory Tract : A Comparative Perspective on
Airway Diseases in
Man and Animal Models . -
pubmed
Members of the
chloride channel regulator , calcium - activated ( CLCA ) family are considered to be modifiers in inflammatory , mucus - based respiratory conditions such as
asthma and
cystic fibrosis . -
pubmed
In the airways of
asthmatic cats ,
CLCA1 was strongly overexpressed , similar to
human patients . -
pubmed
Rosmarinic acid reverses
non - small cell lung cancer cisplatin resistance by activating the
MAPK signaling pathway . -
pubmed
Mechanistically ,
RA inhibited
NSCLC cell growth , arrested cell cycle , and induced apoptosis by activating
MAPK and inhibiting the expression of
P - gp and
MDR1 , which correspondingly enhanced
p21 and
p53 expression . -
pubmed
We demonstrate that
RA is a potentially effective MDR reversal agent for
NSCLC , based on downregulation of
MDR1 mRNA expression and
P - gp . -
pubmed
The complex process of angiogenesis begins when cells within a tissue respond to
hypoxia by increasing their production of
vascular endothelial growth factor (
VEGF ) . -
pubmed
Our results demonstrated that
hypoxia - mimicking materials could induce
VEGF secretion of bone marrow - derived mesenchymal stromal cells ( BMSCs ) , which provided a positive feedback loop for early blood vessel formation by stimulating migration and tube formation of human umbilical vein endothelial cells (
HUVECs ) . -
pubmed
Results : The
CAFs and NF cultured were
proColXIalpha1+/
VIM+ ,
proColXIalpha1 /
alphaSMA+ and
proColXIalpha1+/
CK19 + in different proportions without differences among them , but the CAFs growth curve was significantly larger than that of the NF ( p < 0.05 ) . -
pubmed
These proteins include
EZH2 ,
Snail ,
eIF4E , and
IMPDH , which are all overexpressed in
NPC and correlated with poor prognosis . -
pubmed
Our work suggests that
NPC responds to
ribavirin - mediated
EZH2 ,
Snail ,
eIF4E ,
IMPDH , and
mTOR changes and positions
ribavirin for clinical evaluation as a potential addition to our NPC treatment armamentarium . -
pubmed
The current standard biomarker for
myocardial infarction (
MI ) is high - sensitive
troponin . -
pubmed
EV levels of
CD62P ,
CD42a ,
CD41b ,
CD31 and
CD40 increased in
STEMI , and to a lesser extent in
SA patients . -
pubmed
An aggregate marker including EV concentration and
CD62P /
CD42a levels achieved non - inferiority to
troponin , discriminating
STEMI from controls ( AUC = 0.969 ) . -
pubmed
In contrast to
mice ,
myog-/-
zebrafish are viable , but have
hypotrophic muscles . -
pubmed
Correlation between Genotype and Phenotype in 69 Chinese Patients with
USH2A Mutations : A comparative study of the patients with
Usher Syndrome and
Nonsyndromic Retinitis Pigmentosa . -
pubmed
It included
abdominal pain ( 76.5 % ) ,
diarrhea(20.6 % ) ,
hematochezia(29.4 % ) , and
abdominal mass(2.9 % ) , 85.3 % with B - symptoms , and abnormally elevated
LDH in the serum(73.5 % ) . -
pubmed
Conclusion : Primary intestinal
ENKTL was commonly observed in men at young or middle age , and the most common symptom was
abdominal pain , often with B - symptoms , abnormally elevated
LDH in the serum . -
pubmed
qRT - PCR analyses revealed that samples from all needles were suitable for the detection of PDAC subtype markers (
GATA6 and
ZEB1 ) and splice variants associated with mutational status ( GAP17 ) as well as for the detection of contaminating tissue around
PDAC cells . -
pubmed
Mechanism of circadian regulation of the
NRF2 / ARE pathway in
renal ischemia - reperfusion . -
pubmed
The
nuclear erythroid 2 - related factor 2 (
NRF2)/antioxidant response element ( ARE ) pathway has been shown to provide strong protection against oxidative stress injury induced by
renal ischemia - reperfusion ( IR ) . -
pubmed
However , the endogenous regulatory mechanism of the
NRF2 / ARE pathway in
renal IR injury is incompletely understood . -
pubmed
A
rat model of renal IR was established by occlusion of the bilateral renal pedicle for 45 min , followed by reperfusion for 24 h.
Renal injury was assessed by light microscopy and levels of serum
creatinine , blood
urea nitrogen and
neutrophil gelatinase - associated lipocalin was measured using enzyme - linked immunosorbent assay . -
pubmed
It can be concluded that the circadian rhythm of the
NRF2 / ARE pathway controlled by the circadian clock is essential for regulating antioxidant stress in
renal IR injury , which might prompt new therapeutic strategies associated with the diurnal variability of
human kidney disease , including renal transplantation . -
pubmed
However , an increase in oncogenic potential and a broadening of the tissue specificity of
tumor formation occurs after
retroviral transduction of
erbB. -
pubmed
High - titer
IgG autoantibodies to the
La / SS - B ribonucleoprotein (
RNP ) are a hallmark of patients with primary
Sjogren ' s syndrome . -
pubmed
In vivo induction of
IL-6 by administration of exogenous
cytokines and detection of de novo serum levels of
IL-6 in
tumor - bearing
mice . -
pubmed
We investigated the capacity of several recombinant
cytokines to induce
IL-6 in vivo in both normal and
tumor - bearing ( TB )
mice . -
pubmed
TB animals consistently produced more
IL-6 in response to
rhTNF - alpha than did normal
mice ( 2 h after 4 micrograms
rhTNF - alpha , TB = 24,100
HGF U / ml , non - TB = 3600 HGF U / ml of
IL-6 ) . -
pubmed
dose of
rhTNF - alpha ( 4 micrograms / mouse / day ) for 5 days led to decreased
IL-6 induction in
TB animals by day 3 of treatment ( peak levels of
IL-6 , day 1 = 72,800
HGF U / ml , day 3 = 23,400 HGF U / ml , day 5 = 26,400 HGF U / ml ) . -
pubmed
Administration of
rhIL-1 induced similar
IL-6 levels ( TB = 10,025 and non - TB = 10,600
HGF U / ml ) in
TB and normal
mice . -
pubmed
Single high doses of
rhIL-2 ,
rhIFN - alpha A / D , and
rmIFN - gamma induced lower but consistent levels of circulating
IL-6 in
mice with and without
tumor . -
pubmed
In addition , the sera of untreated
TB mice contained levels of
IL-6 which paralleled the extent of
tumor burden ( serum
IL-6 in day 30 MCA 106 TB
mice = 420
HGF U / ml ) . -
pubmed
The detection of de novo
IL-6 was also confirmed in
animals bearing
tumors of different histologies ( the
MCA 102 sarcoma ,
MCA 38 adenocarcinoma , and
B16 melanoma ) . -
pubmed
Although the exact role of
IL-6 in
TB animals remains to be elucidated , its known pleotrophic immune and metabolic effects may be important in the host response to malignancy . -
pubmed
The potent inhibitor of
platelet cAMP phosphodiesterase (
PDE ) HL 725 (
9,10 - Dimethoxy-2 - mesitylimino-3 - methyl-3 , 4,6,7 - tetrahydro-2H - pyrimido ( 6,1 - A )- isoquinoline-4 - one - hydrochloride ) , was examined for its effects on
human and
rat platelet aggregation . -
pubmed
Strong inhibitory effects are seen on
collagen - induced
platelet aggregation both in
rat platelet - rich plasma ( PRP ) ( IC50 , 54 + /- 12 nM ) and whole blood ( IC50 , 57 + /- 25 nM ) . -
pubmed
The
nucleoside transport inhibitors ,
dilazep and
dipyridamole which are non - inhibitory alone to
platelet aggregation , strongly potentiate ( about 10 - fold ) the inhibitory action of
HL 725 on
collagen - induced
platelet aggregation in
human whole blood . -
pubmed
However , if the whole blood is pretreated with
adenosine deaminase , no inhibitory effect of
dipyridamole plus
HL 725 is seen on
platelet aggregation . -
pubmed
Functional and biochemical characteristics of a putative
quisqualate - type receptor in
rat striatum : effect of
brain lesions . -
pubmed
[ The
TRH test in the pathogenetic diagnosis of
paroxysmal atrial fibrillation ] . -
pubmed
Exposure of
SLE mononuclear cells to autologous ACS caused an increase ( approximately two - fold ) in
IgG production and ISC numbers . -
pubmed
A female
patient with therapy - related
acute non - lymphoblastic leukaemia occurring after intensive combined modality treatment for IIIB
Hodgkin ' s disease was transplanted from her
HLA - identical brother . -
pubmed
Tay - Sachs disease is an
autosomal recessive genetic disorder resulting from mutation of the
HEXA gene encoding the alpha - subunit of the lysosomal enzyme ,
beta - N - acetylhexosaminidase A ( ref . -
pubmed
The thymus in "
bare lymphocyte " syndrome : significance of expression of
major histocompatibility complex antigens on thymic epithelial cells in intrathymic T - cell maturation . -
pubmed
Thymic biopsies from two
patients with combined
immunodeficiency and defective expression of
HLA class I and class II antigens on blood mononuclear cells ( " bare
lymphocyte " syndrome ) were investigated . -
pubmed
Growth inhibition of an MC - induced
mouse sarcoma by
TCGF ( IL 2)-containing preparations . -
pubmed
Supernatants from
Con A - stimulated rat spleen cell cultures containing
T cell growth factor inhibited growth of a transplantable
3 - methylcholanthrene - induced
sarcoma in
syngeneic mice . -
pubmed
The
tumour - inhibitory effects were dependent on the concentration of
T cell growth factor and repeated injections of the supernatants . -
pubmed
The role of
calcitonin and
parathyroid hormone in the pathogenesis of post - thyroidectomy
hypocalcemia . -
pubmed
Though there was no significant
depression of
parathyroid hormone (
PTH ) levels , the failure of the parathyroids to respond to
hypocalcemic stimuli suggests a degree of at least transient
parathyroid insufficiency . -
pubmed
Transiently elevated
CT levels appear to play a significant role in the commonly observed early , transient post - thyroidectomy
hypocalcemia following subtotal and total thyroidectomy . -
pubmed
For all 3
HPT isolates , the expression of
MT protein and mRNA for the
MT-2A ,
MT-1E ,
MT-1F and
MT-1 G isoforms was similar among the isolates and demonstrated no correlation to lethality . -
pubmed
Initially , we detected the presence of
MPS-1 mRNA by message amplification phenotyping in all
condylomata tissues examined . -
pubmed
We found that
MPS-1 mRNA is expressed at high levels in the cytoplasm of
condylomata cells . -
pubmed
All were
insulin - dependent
diabetics . -
pubmed
A control group was established from a pool of randomly selected , age - matched ,
insulin - dependent
diabetics who were also observed for
foot ulcerations . -
pubmed
Lethal skeletal dysplasia from targeted disruption of the
parathyroid hormone - related peptide gene . -
pubmed
Mice homozygous for the
PTHrP null mutation died postnatally , probably from
asphyxia , and exhibited widespread abnormalities of endochondral bone development . -
pubmed
These results provide direct evidence implicating
PTHrP in normal skeletal development and serve to emphasize its potential involvement in
human osteochondrodysplasias . -
pubmed
Since
leukemia cells of immature B - cell origin also synthesize
IL-2R , the
human pre - B cell
leukemias could represent another type of
hematological malignancy where the autocrine processes of
IL-2 production and utilization are involved in the expansion of the disease . -
pubmed
Monocyte chemoattractant protein-1 (
MCP-1 ) mediates monocyte migration into tissues in
inflammatory diseases and
atherosclerosis . -
pubmed
Integrin alpha V beta 3 expression by bone - residing
breast cancer metastases . -
pubmed
The precise adhesion molecules involved in skeletal homing of
breast cancer to bone are unknown but likely include
integrins . -
pubmed
We investigated the expression of
vitronectin receptor (
alpha V beta 3 ) by
breast cancer cells residing in bone because this heterodimer mediates osteoclast - bone recognition . -
pubmed
We used immunohistochemistry and in situ hybridization in a systematic study of 22 bone biopsies containing
breast cancer metastases and available samples of corresponding primary
tumors and
normal breast and compared
alpha V beta 3 ,
alpha 2 beta 1 , and
alpha B beta 5 integrin expression . -
pubmed
The results showed that
alpha V beta 3 was strongly expressed by
normal breast epithelium and was decreased in some and strongly expressed in other primary invasive
breast carcinomas . -
pubmed
In contrast , this
integrin heterodimer was abundant in all
breast cancer cells metastatic to bone . -
pubmed
In situ hybridization revealed high levels of steady - state mRNA corresponding to sites of protein expression ;
alpha 2 beta 1 was weakly expressed in both primary and metastatic
tumors , and
alpha V beta 5 was not detected . -
pubmed
Our results showed an overexpression of
alpha V beta 3 by bone - residing
breast cancer cells and suggest either subclonal selection of
alpha V beta 3 - expressing
tumor cell populations or upregulation of
alpha V beta 3 in the bone microenvironment . -
pubmed
[
Leptin ] in the post - absorptive state was examined in 67 subjects ( 26 male , 20 premenopausal female , 21 postmenopausal females ; 43 never - obese , 24
obese ) at usual body weight . -
pubmed
Activity of the
vitamin B12 - dependent enzyme ,
methylmalonyl CoA mutase , was measured in the tissues of
pigs , fed a diet which was low in
cobalt and
vitamin B12 , and which were intermittently exposed to
nitrous oxide until they displayed marked
ataxia . -
pubmed
The SRC , exclusively present in the
CD4+
CD8- fraction , is capable of multilineage repopulation of the bone marrow of nonobese
diabetic mice with
severe combined immunodeficiency disease (
NOD / SCID mice ) . -
pubmed
To clarify the meaning and clinical value of bone formation markers in bone metastasis from
prostate cancer , we investigated the bone formation markers
carboxy - terminal propeptide of
type I procollagen (
PICP ) ,
bone - specific alkaline phosphatase (
BA1 - p ) and
osteocalcin , so - called
bone gla protein (
BGP ) in 43
prostate cancer patients with and 46
patients without overt
bone metastasis . -
pubmed
The expression patterns of bone formation markers in
patients with progression of bone metastasis became dissociated ; BA1 - p and
PICP were elevated in
patients with progression of
bone metastasis but BGP was not . -
pubmed
NLE is a rare condition which affects newborn infants from mothers who may me asymptomatic or have a
connective tissue disease , with or without autoantibodies to extractable nuclear antigens
Ro ( SS - A ) ,
LA (
SS - B ) or ribonucleoproteins . -
pubmed
The
K +- channel blocker
tetraethylammonium (
TEA ) was applied to study its effects in self - sustaining , circling spreading
depression in the
chicken retina ( RSD ) . -
pubmed
Six Group II
goats had central medial
meniscal tears repaired as in Group I plus an exogenous
fibrin clot . -
pubmed
Interleukin-4 and
interleukin-5 as targets for the inhibition of
eosinophilic inflammation and
allergic airways hyperreactivity . -
pubmed
Clinical and experimental investigations suggest that allergen - specific
CD4 + T - cells ,
IgE and the
cytokines IL-4 and
IL-5 play central roles in initiating and sustaining an
asthmatic response by regulating the recruitment and/or activation of airways mast cells and eosinophils . -
pubmed
IL-5 plays a unique role in eosinophil development and activation and has been strongly implicated in the aetiology of
asthma . -
pubmed
Investigations in
IL-5 -/- mice indicate that this
cytokine is critical for regulating aeroallergen - induced
eosinophilia , the onset of
lung damage and airways hyperreactivity during
allergic airways inflammation . -
pubmed
While
IL-4 and
allergen - specific IgE play important roles in the regulation of
allergic disease , recent investigations in
IL-4-/-
mice suggest that
allergic airways inflammation can occur via pathways which operate independently of these molecules . -
pubmed
Activation of these
IL-4 independent pathways are also intimately associated with
CD4 + T - cells ,
IL-5 signal transduction and
eosinophilic inflammation . -
pubmed
Such
IL-5 regulated pathways may also play a substantive role in the aetiology of
asthma . -
pubmed
The central role of
IL-5 in both components of
allergic disease highlights the requirements for highly specific therapeutic agents which inhibit the production or action of this
cytokine . -
pubmed
Altered inotropic response to
IGF - I in
diabetic rat heart : influence of intracellular
Ca2 + and
NO . -
pubmed
Normally ,
insulin - like growth factor I (
IGF - I ) exerts positive effects on cardiac growth and myocardial contractility , but resistance to its action has been reported in
diabetes . -
pubmed
This study was designed to determine whether
IGF - I - induced myocardial contractile action is altered in
diabetes as a result of an intrinsic alteration of contractile properties at the cellular level . -
pubmed
Contractile responses to
IGF - I were examined in left ventricular papillary muscles and ventricular myocytes from normal and short - term ( 5 - 7 days )
streptozotocin - induced
diabetic rats . -
pubmed
IGF - I ( 1 - 500 ng / ml ) caused a dose - dependent increase in PTD and PTA in preparations from normal but not
diabetic animals . -
pubmed
Pretreatment with the
NO synthase inhibitor
Nomega - nitro - L - arginine methyl ester ( 100 microM ) attenuated
IGF - I - induced increases in PTD in normal myocardium but unmasked a positive inotropic action in
diabetic animals . -
pubmed
Consistent with its inotropic actions on muscles and myocytes ,
IGF - I induced a dose - dependent increase in
Ca2 + transients in normal but not
diabetic myocytes . -
pubmed
These results suggest that the
IGF - I - induced inotropic response is depressed in
diabetes because of an intrinsic alteration at the myocyte level . -
pubmed
Mechanisms underlying this alteration in
IGF - I - induced myocardial response may be related to changes in intracellular
Ca2 + and/or
NO production in
diabetes . -
pubmed
While antibody - dependent cellular
cytotoxicity against
gp120 did not strongly differentiate the groups , slow progressors showed a broader neutralization pattern against 5 primary virus isolates . -
pubmed
dHAND mutants exhibit
hypoplasia of the right ventricle , branchial arches , and aortic arch arteries . -
pubmed
The distinct nature of
cardiac defects in
dHAND mutants provides an entry into dissecting molecular pathways governing morphogenesis of specific components of the heart . -
pubmed
Congenital heart disease is considered as a defect in segmental development of the heart and the role of
dHAND and
eHAND in regulating such developmental pathways in normal and abnormal cardiogenesis is examined . -
pubmed
Recombinant
human interleukin-11 is unlikely to stimulate the growth of the most common
solid tumors . -
pubmed
Recombinant
human interleukin-11 (
rhIL-11 ) has been shown to enhance recovery from
thrombocytopenia and
mucosal injury after
cancer chemotherapy . -
pubmed
Since RNA for the receptor and signal transducer for
IL-11 is detected in many cell types including some
cancer cells , it was theoretically possible that
rhIL-11 could affect the growth of
tumor cells . -
pubmed
This study was intended to determine whether
rhIL-11 stimulates the proliferation of
human tumor colony - forming units ( TCFUs ) taken directly from
patients . -
pubmed
Tumor cells were cultured in soft agar and continuously exposed to three concentrations of
rhIL-11 ( 1.0 , 10.0 and 100.0 U / ml ) for 14 days in the capillary cloning system . -
pubmed
These results suggest that
rhIL-11 appears unlikely to stimulate the growth of the most common
solid tumors . -
pubmed
[ The effects of
angiotensin II receptor antagonists on
insulin resistance ] . -
pubmed
We reviewed the effects of
angiotensin II receptor antagonists on
insulin resistant syndrome . -
pubmed
Central nervous system - targeted expression of the complement inhibitor
sCrry prevents
experimental allergic encephalomyelitis . -
pubmed
Here , we show that
sCrry transgenic
mice are either fully protected against
EAE or develop significantly delayed clinical signs . -
pubmed
Allele - specific loss or imbalance of chromosomes 9 , 15 , and 16 in
B - cell tumors from interspecific F1 hybrid
mice carrying Emu -
c - myc or
N - myc transgenes . -
pubmed
Mice carrying an immunoglobulin enhancer ( Emu- ) linked c- or
N - myc transgene develop fatal monoclonal or oligoclonal pre - B or
B - cell lymphomas . -
pubmed
This was done at 53 microsatellite markers in a panel of 34
lymphomas and four
plasmacytomas from
c - or N - myc transgene carrying ( BALB / c
x Mus spretus)F1 hybrids . -
pubmed
Staining of
malignant mesothelioma for the
trefoil protein pS2 . -
pubmed
Increased
fatty acid uptake and altered
fatty acid metabolism in
insulin - resistant muscle of
obese Zucker
rats . -
pubmed
To determine whether FA uptake and disposal are altered in
insulin - resistant muscle , we measured
palmitate uptake , oxidation , and incorporation into di- and
triglycerides in isolated
rat hindquarters , as well as muscle plasma membrane
fatty acid - binding protein (
FABP(PM ) ) content of lean ( n = 16 , fa/+ ) and
obese ( n = 15 , fa / fa ) Zucker
rats ( 12 weeks of age ) . -
pubmed
Glucose uptake was 42 % lower in the
obese than in the lean
rats and indicated the presence of muscle
insulin resistance . -
pubmed
Fractional and total rates of
palmitate uptake were 42 and 74 % higher in the
obese than in the lean
rats and were associated with higher muscle
FABP(PM ) content ( r(2 ) = 0.69 , P & lt ; 0.05 ) . -
pubmed
It was previously reported that silencing of the expression of
glutamic acid decarboxylase (
GAD ) in transgenic
nonobese diabetic ( NOD ) mice completely protected islet beta - cells against development of
diabetes . -
pubmed
The levels of total serum
bilirubin ( P<0.05 ) and
serum transaminases ( P<0.05 ) were significantly higher in patients with
AIH -
AH than in patients with AIH - CH and
AIH - LC . -
pubmed
However , the serum levels of
gamma - globulin ( P<0.05 ) and
immunoglobulin G ( P<0.05 ) were significantly lower in AIH - AH than in patients with
AIH - CH and
AIH - LC . -
pubmed
Limited proteolysis as a post - translational modification will be discussed , focusing on the family of membrane protein secretases , in particular in relation to the
Alzheimer 's
amyloid precursor protein . -
pubmed
Expression of
frizzled - related protein and
Wnt - signalling molecules in invasive
human breast tumours . -
pubmed
To explore the role of
Frp and its relationship to the
Wnt - signalling pathway in
breast cancer , in situ hybridization and immunohistochemical analyses of
Frp ,
Wnt-1 ,
APC ,
beta - catenin , and its target genes
c - myc and
cyclin D1 were conducted in 70 specimens of invasive
ductal carcinomas of the human breast . -
pubmed
Frp mRNA was down - regulated in 62 and elevated in eight
tumour specimens , compared with adjacent
normal tissues . -
pubmed
In the course of
tumour progression , however ,
Frp mRNA steadily increased in both
tumour and the adjacent tissues . -
pubmed
Interestingly , the number of cases with axillary lymph node metastasis was significantly lower in the group with elevated
Frp than in the group with decreased
Frp , suggesting that
Frp may contribute as a prognostic factor in invasive
breast cancer . -
pubmed
Wnt-1 , a gene implicated in
human breast cancer , was markedly elevated in grade 1
tumours , but declined as
tumour grade declined . -
pubmed
Beta - catenin , a key transcriptional activator responsible for the activation of both
c - myc and
cyclin D1 in colorectal
tumours , was detected at high levels in the plasma membranes of cells in
normal tissue . -
pubmed
In
tumour masses , however ,
beta - catenin lost its tight association with the membrane and diffused into the cytoplasm . -
pubmed
Surprisingly , it clearly did not penetrate the nuclei , despite the fact that both
c - myc and
cyclin D1 were markedly elevated in all
tumour tissues . -
pubmed
As revealed in this study ,
Wnt-1 /
beta - catenin plays very different roles in the oncogenesis of breast and
colon cancers . -
pubmed
This first systemic analysis of the
Frp and the
Wnt - signalling pathway in
human breast cancer provides a springboard for further work on the role of
Frp in the development of
breast cancer . -
pubmed
These results suggest that
ET-1 at low concentration can protect the microsomal
CCT activity and reduce the inhibition of PS lipid synthesis induced by oxidant
lung injury . -
pubmed
Impact of
obesity and
leptin levels on the secretion of
estradiol ,
inhibin A and
inhibin B during ovarian stimulation with
gonadotropins . -
pubmed
We examined the impact of high
leptin levels on the secretion of
estradiol ,
inhibin A and
inhibin B in
obese and lean
women during ovarian stimulation . -
pubmed
Obese women ( body mass index ( BMI ) & gt ; 28 kg / m(2 ) ; n = 17 ) were individually matched with lean
women ( BMI 20 - 25 kg / m(2 ) ; n = 17 ) for age and baseline
follicle stimulating hormone and
luteinizing hormone concentrations . -
pubmed
In the
obese group , area - under - the - curve ( AUC )
leptin levels correlated with AUC
inhibin A levels . -
pubmed
Progressive age - related
impairment of cognitive behavior in
APP23 transgenic
mice . -
pubmed
In conclusion ,
APP23 mice exhibit both early
behavioral impairment in the large Morris maze as well as impairments in passive avoidance and small pool performance that are marked only in old age . -
pubmed
No patient with relapsed
AML achieved CR , while it was achieved by five of eight
patients with
secondary AML at diagnosis ; five of six
MDR1 + patients achieved CR . -
pubmed
As concerns follow - up of the CR patients , one did not receive any further treatment and died in CR from
pulmonary aspergillosis , and one with a concomitant
chronic lymphocytic leukemia (
CLL ) received two courses of FLAG (
fludarabine ,
cytarabine ,
granulocyte colony - stimulating factor ) regimen with disappearance of the clonal
Ig rearrangement , but relapsed after 11 months and died from
pneumonia . -
pubmed
Hemolytic disease of the newborn due to the rare blood factor ,
rhw(Cw ) . -
pubmed
Effect of some
glycosidase inhibitors on experimental
tumours in the
mouse . -
pubmed
Histopathological study on the
PTHrP - induced
incisor lesions in
rats . -
pubmed
Parathyroid hormone related peptide (
PTHrP ) was discovered as a causative factor of
humoral hypercalcemia of malignancy (
HHM ) . -
pubmed
Nude rats were implanted with
PTHrP - expressing
tumor (
LC-6 ) cells , maintained for 12 weeks , after which the mandibular incisors were collected . -
pubmed
These results suggest that
hypercalcemia affected the entire calcification process resulting in hypercalcified dentin , and that high
PTHrP concentrations affected selective populations of odontoblasts resulting in formation of dentin niche and thinning of dentin . -
pubmed
The expression of the neuropeptide
galanin is markedly up - regulated in many areas of the central and peripheral nervous system after
injury . -
pubmed
We have recently demonstrated that peripheral sensory neurons depend on
galanin for neurite extension after
injury , mediated by activation of the second
galanin receptor subtype (
GALR2 ) . -
pubmed
These results demonstrate that
galanin acts an endogenous neuroprotective factor to the hippocampus and imply that a
galanin agonist might have therapeutic uses in some forms of
brain injury . -
pubmed
The
HER-2 - targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of
breast cancer cells . -
pubmed
We explored combination effects of these agents in the
HER-2 - overexpressing
BT474 breast cancer cell line . -
pubmed
These results suggest that combining
HER-2 - targeting agents may be a more effective therapeutic strategy in
breast cancer rather than treating with a single
HER-2 monoclonal antibody . -
pubmed
Polymorphisms of
chemokine and chemokine receptor genes in
Type 1 diabetes mellitus and its complications . -
pubmed
Cytokines and
chemokines have been implicated in the pathogenesis of
Type 1 diabetes mellitus (
T1DM ) and its
microvascular complications . -
pubmed
The aim was to investigate whether genetic variants of the
MCP-1 G(-2518)A ,
CCR2B 64I ,
CCR5 G(59029)A , and
CCR5 Delta32 are associated with
T1DM and its
microvascular complications . -
pubmed
Frequencies of the
MCP-1 A(-2518 ) allele ( 74.6 % vs. 63.5 % , p & lt ; 0.003 ) and A / A genotype ( 54.5 % vs. 34.6 % , p & lt ; 0.001 , Pc = 0.002 ) were significantly higher in patients with
T1DM compared with normal controls . -
pubmed
CCR5 G(59029 ) was slightly increased in the patients with
microvascular complications compared with the uncomplicated ( 21.4 % vs. 10 % , p & lt ; 0.03 , Pc = ns ) . -
pubmed
These results suggest that polymorphisms of the
MCP-1 ,
CCR2 and
CCR5 genes may be associated with
T1DM and its complications . -
pubmed
TNF - alpha - transduced synoviocytes injected into the knee joints of
severe combined immunodeficient ( SCID ) mice induced cell proliferation , as well as
cartilage and bone erosion as soon as day 7 , creating a standardized , humanized
animal model relevant for
rheumatoid arthritis . -
pubmed
For example , the
ATP - binding cassette (
ABC ) drug transporters have been shown to protect
cancer stem cells from chemotherapeutic agents . -
pubmed
Targeting the
c - Met pathway potentiates
glioblastoma responses to gamma - radiation . -
pubmed
EXPERIMENTAL DESIGN : Endogenous expression of
SF /
HGF and
c - Met was targeted in
U87 MG human malignant glioma cells and xenografts using chimeric U1 / ribozymes . -
pubmed
RESULTS : U1 / ribozymes knocked down
SF /
HGF and
c - Met mRNA and protein levels , sensitized cells to gamma - radiation ( P & lt ; 0.005 ) , and enhanced radiation - induced
caspase - dependent
cytotoxicity in vitro ( P & lt ; 0.005 ) . -
pubmed
CONCLUSIONS : Targeting the
SF /
HGF /
c - Met pathway markedly potentiates the anti -
glioma response to gamma - radiation . -
pubmed
Clinical trials using novel
SF /
HGF /
c - Met pathway inhibitors in
glioma and other
malignancies associated with
c - Met activation should ultimate include concurrent radiation and potentially other cytotoxic therapeutics . -
pubmed
Seventeen ( 70.8 % ) of the 24
melanomas showed a copy number loss of either the
CDKN2A or
CDKN2B gene on chromosome 9p21 . -
pubmed
BACKGROUND :
Inflammation is a predominant characteristic of
autoimmune diseases which is characterized by the increased expression of pro - inflammatory
cytokines . -
pubmed
The current paper attempts to illustrate how Perna can alleviate
inflammation by modulating inflammatory
cytokines ,
cyclooxygenase enzymes and
Immunoglobulin - G (
IgG ) levels . -
pubmed
CONCLUSION : We have successfully demonstrated modulation in the levels of
inflammatory cytokines ,
cyclooxygenase enzymes and
immunoglobulins by our in - house laboratory preparations of
Perna canaliculus , whereby suggesting an immunomodulatory role of Perna canaliculus in regulating
inflammation . -
pubmed
DESIGN : Prior to initiating
anemia control interventions , schoolgirls in early adolescence were studied with regard to their
hemoglobin status , physical work capacity and cognitive functions . -
pubmed
RESULTS : The mean
hemoglobin was 11.32 g / dL , and
anemia prevalence : 67 % . -
pubmed
TGF - beta in
cancer and as a therapeutic target . -
pubmed
Transforming growth factor - beta which is a growth suppressive cytokine in many normal situations becomes an active and important participant in
malignant disease including angiogenesis , extracellular matrix deposition , immuno - suppression and metastasis growth promotion . -
pubmed
Tumor - suspect nodules previously considered disease free by HE stain on whole - mount section were examined by in situ hybridization ( ISH ) on tissue microarray ( TMA ) through detecting mRNAs of
CEA and
CK20 with non radioactive
biotin - tagged oligonucleotide probes . -
pubmed
Thus , management of
iNOS expression or activity prior to intestinal surgery protects against
postsurgical dysmotility and reduces the severity of
postoperative ileus . -
pubmed
Downregulation of
c - FLIP promotes
caspase - dependent
JNK activation and reactive
oxygen species accumulation in
tumor cells . -
pubmed
To suppress this antiapoptotic function of
NF - kappaB might be a promising strategy to increase susceptibility of
tumor cells to stress - induced cell death . -
pubmed
To apply this observation to tumor therapy , we knocked down
c - FLIP by RNA interference in various
tumor cells . -
pubmed
Consistent with the results using
c - Flip(-/- ) MEFs , we found that
TNFalpha stimulation induced
caspase - dependent prolonged
JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various
tumor cells . -
pubmed
Given that ROS accumulation and necrotic cell death enhance
inflammation followed by compensatory proliferation of
tumor cells , selective suppression of
caspase - dependent ROS accumulation will be an alternative strategy to protect cells from ROS - dependent DNA damage and compensatory
tumor progression . -
pubmed
Using an excisional wound splinting model , we showed that injection around the wound and application to the wound bed of
green fluorescence protein (
GFP)(+ ) allogeneic BM - MSCs significantly enhanced
wound healing in normal and
diabetic mice compared with that of allogeneic neonatal dermal fibroblasts or vehicle control medium . -
pubmed
We show that attenuation of
Cx43 - mediated communication by a Cx mimetic peptide enhanced
wound closure rates in keratinocyte monocultures and in the living skin equivalent system , emphasising the utility of the model to systematically unravel the molecular mechanisms underlying epidermal morphogenesis , assess promising therapeutic strategies , and reduce
animal experimentation . -
pubmed
Here we investigated whether the dysfunction of the ubiquitin proteasome system might be involved in the pathogenesis and regional selectivity of neuronal ubiquitinated inclusions using the
SAMP10 strain of
mouse , an inbred model of age - related
cerebral degeneration . -
pubmed
Prophylaxis with
rhGM - CSF was associated with significantly fewer life - threatening and serious ( grade & gt ; or =3 )
infections , especially in older
patients undergoing treatment for
AML . -
pubmed
The limited experience with
rhGM - CSF for the treatment of invasive
fungal infections in combination with antifungal drug(s ) was associated with a favorable outcome , and in contrast to
Escherichia coli - derived
rhGM - CSF , the new preparation ( sargramostim ) was well tolerated and rarely associated with serious
systemic toxicities . -
pubmed
Similarly ,
IFN - gamma has been successfully used in
patients with antimicrobial drug - refractory and/or disseminated
fungal infection . -
pubmed
In difficult - to - treat
fungal infections , the addition of
cytokines appears to improve outcome and may be considered early in severely immunosuppressed
patients with
AML . -
pubmed
In this prospective randomized study , we investigated the effect of
raloxifene on the echocardiographic parameters of left ventricular diastolic and systolic function and on blood levels of lipids ,
homocysteine , and
lipoprotein ( a ) in postmenopausal
osteoporotic patients and compared the results with those treated with
risedronate . -
pubmed
Expression of
gamma - H2AX in
melanocytic lesions . -
pubmed
gamma - H2AX is a marker of activated DNA damage and is overexpressed in many
malignancies and their precursor lesions . -
pubmed
Previous studies have demonstrated the expression of
gamma - H2AX in
melanoma and
dysplastic nevus , but its diagnostic and prognostic utility in a full range of
melanocytic lesions has not been fully studied . -
pubmed
In the current study , we investigated
gamma - H2AX expression in a total of 162
melanocytic lesions . -
pubmed
We found that
gamma - H2AX was observed at higher levels ( percentage and intensity of staining ) in
melanoma in situ ( 12/13 ) , primary cutaneous
melanoma ( 32/33 ; with the exception of
desmoplastic melanoma ) , and metastatic
melanoma ( 58/62 ) , which was statistically different from that in benign
nevus ( 7/9 ) ,
dysplastic nevus ( 6/10 ) , and
Spitz nevus ( 5/9 ) considered together ( P & lt ; .0001 ) . -
pubmed
Of note ,
desmoplastic melanoma ( 20/26 ) demonstrated weak or negative
gamma - H2AX staining . -
pubmed
The expression of
gamma - H2AX did not show significant correlation with many
melanoma prognostic factors , including Breslow depth , mitotic rate , and sentinel lymph node status . -
pubmed
Except for
desmoplastic melanoma , no difference in
gamma - H2AX levels was observed among various
melanoma subtypes . -
pubmed
The overexpression of
gamma - H2AX in
melanoma as opposed to
nevus indicates its possible role in melanomagenesis . -
pubmed
DIAGNOSIS / TESTING :
CMT1A ( 70%-80 % of all
CMT1 ) involves duplication of
PMP22 . -
pubmed
CMT2E/1F ( & lt;5 % of all
CMT1 ) is associated with pathogenic variants in
NEFL . -
pubmed
GENETIC COUNSELING :
CMT1 is inherited in an autosomal dominant manner . -
pubmed
About two thirds of probands with
CMT1A have inherited the
PMP22 duplication ; about one third have
CMT1A as the result of a de novo pathogenic variant . -
pubmed
[ Effects of differentially expressed proteins in
hepatocellular carcinoma cell treated by different
telomerase inhibitors ] . -
pubmed
OBJECTIVE : To detect differentially expressed proteins in
hepatocellular carcinoma cell line
SMMC-7721 treated separately by eight
telomerase inhibitors including antisense
oligodeoxynuclectide of
human telomerase RNA ( hTR - ASODN ) , sense oligodeoxynuclectide of
hTR (
hTR - SODN ) , ASODN of
human telomerase reverse transcriptase (
hTERT - ASODN ) , SODN of
hTERT (
hTERT - SODN ) ,
epigallocatechin gallate (
EGCG ) ,
3 '- azido-3 '- deoxythymidine (
AZT ) ,
all trans - retinoic acid (
ATRA ) and
adriamycin (
ADM ) using surface enhanced laser desorption / ionization time of flight - mass spectrom ( SELDI - TOF - MS ) technology . -
pubmed
On 23 October 2009 , the commissioner of the US Food and Drug Administration ( FDA ) issued an Emergency Use Authorization ( EUA ) for
peramivir for intravenous injection , an unapproved
neuraminidase inhibitor used for treating certain hospitalized adult and pediatric patients infected with 2009
H1N1 influenza . -
pubmed
During the course of
heparin - induced extracorporeal lipoprotein apheresis , a
patient with no prior known
renal impairment or
proteinuria demonstrated sustained improvement in estimated glomerular filtration rate , commensurate with reduction in serum lipids and
creatine phosphokinase levels . -
pubmed
DNA hypermethylation and histone modifications downregulate the candidate
tumor suppressor gene
RRP22 on 22q12 in
human gliomas . -
pubmed
RRP22 (
Ras - related protein on chromosome 22 ) has been suggested as a candidate tumor suppressor in
human cancers . -
pubmed
Investigating a panel of 70
human gliomas , we found a frequent decrease in the
RRP22 mRNA expression levels ( 67 % ) , preferentially in
high - grade gliomas [ World Health Organization ( WHO ) grades III and IV ] as compared with
low - grade gliomas ( WHO grade II ) . -
pubmed
Moreover , reduced
RRP22 mRNA expression was associated with shorter overall survival in 180
glioblastoma patients included in the National Institutes of Health Repository for Molecular Brain Neoplasia Data ( NIH REMBRANDT ) database . -
pubmed
Decreased
RRP22 expression levels were in part explained by 5'-CpG island hypermethylation and increased by the treatment with the demethylating agent
5 - aza-2 '- deoxycytidine in
glioblastoma cell lines . -
pubmed
Moreover , in primary
human glioblastomas , we observed an increase of H3K9me3 - bound and a decrease of pan - Ac -
H3 - bound
RRP22 in comparison with non - neoplastic brain tissue , consistent with a heterochromatinization of the
RRP22 promoter . -
pubmed
Taken together , our findings demonstrate that both 5'-CpG island hypermethylation and histone modifications contribute to the frequent and prognostically unfavorable transcriptional downregulation of
RRP22 in
malignant gliomas . -
pubmed
[ Expression of
beta - endorphin in
hypertrophic scar and its relationship with
pruritus ] . -
pubmed
OBJECTIVE : To identify the effect of
beta - endorphin in the development of
paresthesia in
hypertrophic scar by detecting the expression and content of
beta - endorphin in
human normal skin and
hypertrophic scar . -
pubmed
RESULTS : The
beta - endorphin expressed in all samples , and it expressed around peripheral nerve fibers in the dermis , fibroblasts , and monocytoid cells principally ; and it expressed significantly stronger in
pruritus group and
pain -
pruritus group than in non -
pain -
pruritus group and normal skin group . -
pubmed
The
beta - endorphin content was ( 617.401 + /- 97.518 ) pg / mL in non -
pain -
pruritus group , ( 739.543 + /- 94.149 ) pg / mL in
pruritus group , ( 623.294 + /- 149.613 ) pg / mL in
pain -
pruritus group , and ( 319.734 + /- 85.301 ) pg / mL in normal skin group ; it was significantly higher in non -
pain -
pruritus group ,
pruritus group , and
pain -
pruritus group than in normal skin group ( P & lt ; 0.05 ) ; it was significantly higher in
pruritus group than in non -
pain -
pruritus group and
pain -
pruritus group ( P & lt ; 0.05 ) ; and there was no significant difference between non -
pain -
pruritus group and
pain -
pruritus group ( P & gt ; 0.05 ) . -
pubmed
CONCLUSION : The expression of
beta - endorphin is high in
hypertrophic scar , it may play an important role in process of
pruritus in these
patients . -
pubmed
In
Parkinson ' s disease , while
D2 / 3 dopamine agonists alleviate motor symptoms , behavioral addictions and
withdrawal syndrome are reported in up to 15 % of
patients . -
pubmed
We evaluated the reinforcing properties of the widely used
D2 / 3 agonist ,
Pramipexole (
PPX ) , in normal and
parkinsonian rats . -
pubmed
Within 2 h of injection ,
SE induced selective transcription of
TLR2 and
MyD88 in the liver , and increased systemic production of plasma
IL-6 and
TNF - alpha . -
pubmed
Measurements of lung function ( compliance and resistance ) , development ( morphometry ) ,
inflammation ( histology ; multiplex analysis of bronchoalveolar lavage fluid for
cytokines ; PCR array and multiplex analysis of lung homogenates for
cytokines ) was performed on postnatal day 14 . -
pubmed
Elucidation of the crystal structure will provide insights into the interactions of
Spy0843 with the
gp340 receptor and a better understanding of the role of
Spy0843 in
streptococcal infections . -
pubmed
Human mitochondrial voltage - dependent anion channel 2 (
hVDAC-2 ) , the most predominant isoform seen in brain mitochondria , is not only crucial for cell survival but is also implicated in
Alzheimer disease . -
pubmed
Prostate cancer :
PSA enzymatic activity to assess disease aggressiveness . -
pubmed
Ustekinumab , an anti -
IL-12 / 23 p40 monoclonal antibody , inhibits radiographic progression in
patients with active
psoriatic arthritis : results of an integrated analysis of radiographic data from the phase 3 , multicentre , randomised , double - blind , placebo - controlled PSUMMIT-1 and PSUMMIT-2 trials . -
pubmed
OBJECTIVE : Evaluate ustekinumab , an anti -
interleukin ( IL )- 12 and
IL-23 antibody , effects on radiographic progression in
psoriatic arthritis (
PsA ) . -
pubmed
Patients had active
PsA despite prior conventional and/or biologic disease - modifying antirheumatic drugs ( & gt;=5/66 swollen , & gt;=5/68 tender joints ,
C - reactive protein & gt;=3.0 mg / L , documented
plaque psoriasis ) . -
pubmed
Defective adipose tissue development associated with
hepatomegaly in
cathepsin E - deficient
mice fed a high - fat diet . -
pubmed
In this study , we investigated the characteristics of
cathepsin E - deficient (
CatE(-/- ) )
mice fed a high - fat diet ( HFD ) , as a
mouse model of
obesity . -
pubmed
Thus , the impaired adipose tissue development in HFD - induced
CatE(-/- )
mice was probably due to reduced infiltration of macrophages and may lead to
hepatomegaly accompanied by
hepatic steatosis and
hypercholesterolemia . -
pubmed
Barriers to initiating
insulin in
type 2 diabetes patients : development of a new patient education tool to address myths , misconceptions and clinical realities . -
pubmed
PURPOSE : The purpose of this study was to identify patient beliefs as well as clinical realities about
insulin that may be barriers to
type 2 diabetes patients initiating
insulin treatment when recommended by their physician . -
pubmed
METHODS : Thirteen focus groups were conducted in five countries ( Germany , Sweden , The Netherlands , UK , and USA ) to collect qualitative data on attitudes about
insulin therapy from
type 2 diabetes patients aged 18 or older whose physician had recommended initiating
insulin treatment in the past 6 months ( n = 87 ) . -
pubmed
CONCLUSIONS : Patient misconceptions , as well as some clinical realities , about
insulin treatment and
diabetes can influence the decision to initiate
insulin treatment and ultimately impact disease management . -
pubmed
Efficacy of some non - conventional herbal medications (
sulforaphane ,
tanshinone IIA , and
tetramethylpyrazine ) in inducing neuroprotection in comparison with
interleukin-10 after
spinal cord injury : A meta - analysis . -
pubmed
OBJECTIVES : To assess the efficacy of some non - conventional herbal medications including
sulforaphane ,
tanshinone IIA , and
tetramethylpyrazine in reducing
inflammation and compare them with a known effective anti - inflammatory agent (
interleukin-10 (
IL-10 ) ) . -
pubmed
CONCLUSION :
IL-10 has a strong effect in the induction of neuroprotection and neurorecovery after
SCI by multiple pathways . -
pubmed
Tetramethylpyrazine has an acceptable influence in reducing
inflammation through the up - regulation of
IL-10 . -
pubmed
Analysis of the trajectory of
osteoarthritis development in a
mouse model by serial near - infrared fluorescence imaging of
matrix metalloproteinase activities . -
pubmed
It is hypothesized that proteases , such as
matrix metalloproteinases (
MMPs ) , are up - regulated in the early stages of
OA development . -
pubmed
This study was undertaken to investigate if a near - infrared ( NIR ) fluorescent probe activated by
MMPs could visualize in vivo
OA progression beginning in the early stages of the disease . -
pubmed
MMP activity was then evaluated in vivo serially in a
mouse model of chronic , injury - induced
OA . -
pubmed
CONCLUSION : Imaging of
MMP activity in a
mouse model of
OA provides sensitive and consistent visualization of
OA progression , beginning in the early stages of
OA . -
pubmed
Pemetrexed Singlet Versus Nonpemetrexed - Based
Platinum Doublet as Second - Line Chemotherapy after First - Line
Epidermal Growth Factor Receptor (
EGFR )
Tyrosine Kinase Inhibitor Failure in
Non - small Cell Lung Cancer Patients with
EGFR Mutations . -
pubmed
PURPOSE :
Platinum - based doublet chemotherapy is the treatment of choice for
patients with
non - small cell lung cancer (
NSCLC ) ; however , the role of a
platinum - based doublet as second - line therapy after failure of an
epidermal growth factor receptor (
EGFR )
tyrosine kinase inhibitor ( TKI ) for
NSCLC patients has not yet been elucidated . -
pubmed
The purpose of this study was to compare the clinical efficacy of
pemetrexed versus a
platinum - based doublet as second - line therapy after failure of
EGFR TKI used as first - line therapy for
NSCLC patients with
EGFR mutations . -
pubmed
MATERIALS AND METHODS : We designed a multicenter retrospective cohort study of 314
NSCLC patients with
EGFR mutations who received an
EGFR TKI as first - line palliative chemotherapy . -
pubmed
CONCLUSION : Our retrospective analysis found that second - line
pemetrexed singlet therapy provided significantly prolonged PFS compared to second - line
platinum - based doublet chemotherapy for
NSCLC patients with
EGFR mutations who failed first - line
EGFR TKI . -
pubmed
Increased cell adhesion ,
alpha - smooth muscle actin (
alpha - SMA ) expression and increased extracellular matrix deposition are a hallmark of fibrotic cells , but how topographic features influence gingival fibroblast adhesion and adoption of the
alpha - SMA positive myofibroblast phenotype associated with
scarring is unknown . -
pubmed
Mannose - binding lectin gene polymorphism and
chronic hepatitis B infection in children . -
pubmed
In this study , the relation between
MBL gene polymorphism and
chronic hepatitis B infection in
children is evaluated . -
pubmed
RESULTS : Homozygous codon 54 polymorphism of
MBL was found significantly higher in
chronic hepatitis B patients than controls . -
pubmed
CONCLUSIONS : The
hepatitis B patients who are homozygous for codon 54 of
MBL are prone to develop
chronic infection . -
pubmed
Strong staining of
fibronectin and
p - CREB was detected in kidney cortex of db / db
mice while treated
mice with
rapamycin reversed
hyperglycemia effect . -
pubmed
In summary , our data provide a novel mechanism of transcriptional regulation of
fibronectin through
CREB that may be used as therapeutic approach to prevent
diabetes complications . -
pubmed
Correct diagnosis of
HIT followed by therapy based on
histamine - free diet and supplementation of
diamine oxidase can improve
patient 's quality of life . -
pubmed
HOXA13 is a potential GBM diagnostic marker and promotes
glioma invasion by activating the Wnt and
TGF - beta pathways . -
pubmed
Homeobox (
HOX ) genes , including
HOXA13 , are involved in
human cancer . -
pubmed
We found that
HOXA13 expression was associated with
glioma grade and prognosis . -
pubmed
Bioinformatics analysis revealed that most of the
HOXA13 - associated genes were enriched in
cancer - related signaling pathways and mainly involved in the regulation of transcription . -
pubmed
We transfected four
glioma cell lines with Lenti - si
HOXA13 . -
pubmed
Furthermore , downregulation of
HOXA13 in
orthotopic tumors decreased
tumor growth . -
pubmed
We suggest that
HOXA13 promotes
glioma progression in part via Wnt- and
TGF - beta - induced EMT and is a potential diagnostic biomarker for
glioblastoma and an independent prognostic factor in
high - grade glioma . -
pubmed
IL-37 mediates the antitumor activity in
renal cell carcinoma . -
pubmed
The aim of this study was to investigate the role of
IL-37 in
renal cell carcinoma (
Rcc ) . -
pubmed
The expression of
IL-37 was decreased in Rcc
patients and was negatively correlated with
tumor progression . -
pubmed
In vivo ,
tumor growth and gene expressions of
IL-6 and
HIF-1alpha were suppressed by
IL-37 . -
pubmed
TGF - beta1 prevents
rat retinal insult induced by
amyloid - beta ( 1 - 42 ) oligomers . -
pubmed
To set up a
retinal degenerative model in
rat that mimics pathologic conditions such as age - related
macular degeneration (
AMD ) using
amyloid - beta (
Abeta ) oligomers , and assess the effect of
TGF - beta1 . -
pubmed
Bioinformatic analysis revealed that
Bcl-2 and
PI3K -
Akt are the most connected nodes , for genes and pathways respectively , in the enriched gene - pathway network common to
AMD and
Alzheimer disease (
AD ) . -
pubmed
Overall , these data indicate that ITV injection of
Abeta1 - 42 oligomers in
rat induces molecular changes associated with apoptosis in
rat retina , highlighting a potential pathogenetic role of
Abeta oligomers in
AMD . -
pubmed
Furthermore , these findings suggest that
human recombinant
TGF - beta1 can prevent
retinal damage elicited by
Abeta oligomers . -
pubmed
The Interaction of
UDP - N - Acetylglucosamine 2 - Epimerase /
N - Acetylmannosamine Kinase (
GNE ) and
Alpha - Actinin 2 Is Altered in
GNE Myopathy M743 T Mutant . -
pubmed
UDP - N - acetylglucosamine 2 - epimerase /
N - acetylmannosamine kinase (
GNE ) is the gene mutated in
GNE myopathy . -
pubmed
Further ,
GNE carrying the M743 T mutation , the most frequent mutation in
GNE myopathy , has a 10 - fold lower binding affinity to
alpha - actinin 2 than intact
GNE . -
pubmed
Lack of Association between
NYD - SP18 Variant and
Obesity . -
pubmed
CONCLUSION : This study in a large Slavonic population sample suggests that the rs6971091 variant within the
NYD -
SP18 gene is not an important determinant of
obesity in middle - aged persons . -
pubmed
Vascular endothelial growth factor (
VEGF)-neutralizing proteins provide benefit in several
retinal and choroidal vascular diseases , but some
patients still experience suboptimal outcomes , and the need for frequent intraocular injections is a barrier to good outcomes . -
pubmed
A mimetic peptide derived from
collagen IV , AXT107 , suppressed subretinal neovascularization ( NV ) in two
mouse models predictive of effects in neovascular age - related
macular degeneration (
NVAMD ) and inhibited retinal NV in a model predictive of effects in
ischemic retinopathies . -
pubmed
AXT107 reduced the
VEGF - induced vascular leakage that underlies
macular edema in
ischemic retinopathies and
NVAMD . -
pubmed
In
rabbit eyes , which are closer to the size of
human eyes , intraocular injection of AXT107 significantly reduced
VEGF - induced
vascular leakage by 86 % at 1 month and 70 % at 2 months ; aflibercept significantly reduced leakage by 69 % at 1 month and did not reduce leakage at 2 months , demonstrating the longer effectiveness of AXT107 . -
pubmed
In the present study we evaluated the effect of the
dopamine D1 - and D2 - like receptor antagonists (
SCH23390 and
raclopride , respectively ) on the short - time effects of acute social defeat (
ASD ) . -
pubmed
Mice exposed to
ASD showed an increase in reinstatement of the conditioned reinforcing effects of
cocaine that was blocked by all of the
dopamine receptor antagonists . -
pubmed
The
dopamine D1 receptor is clearly involved in the rewarding effects of
cocaine , but its role in the effects of
ASD remains to be demonstrated . -
pubmed
The
tyrosine kinase inhibitor
imatinib mesylate suppresses
uric acid crystal - induced acute
gouty arthritis in
mice . -
pubmed
Tyrosine kinase inhibitors have demonstrated therapeutic benefit in experimental models of
antibody - dependent arthritis and in
rheumatoid arthritis in
humans , but to date , the potential effects of such inhibitors on
gouty arthritis has not been evaluated . -
pubmed
Here we demonstrate that treatment with the
tyrosine kinase inhibitor
imatinib mesylate (
imatinib ) can suppress
inflammation induced by injection of MSU crystals into subcutaneous air pouches or into the ankle joint of wild type
mice . -
pubmed
Moreover ,
imatinib treatment also largely abolished the lower levels of
inflammation which developed in
IL-1R1-/- or
KitW - sh / W - sh
mice , indicating that this drug can inhibit
IL-1 - independent pathways , as well as mast cell - independent pathways , contributing to pathology in this model . -
pubmed
Altogether , these results raise the possibility that
tyrosine kinase inhibitors might have utility in the treatment of acute
gout in
humans . -
pubmed
More valuable information could probably be provided about the variety of the diseases caused by
superoxide anions
toxicities by intervention and application of the non - viral method for expressions of
SOD1 and
SOD3 enzymes . -
pubmed
Of note ,
CD96 expression was highly correlated with
T - cell markers in primary and metastatic
human tumors and was elevated on antigen - experienced T cells and
tumor - infiltrating lymphocytes . -
pubmed
Collectively , these data demonstrate that
CD96 may be a promising immune checkpoint to enhance T - cell function against
human cancer and
infectious disease . -
pubmed
In summary , the structural elucidation of
opioid receptors , allosteric modulation of
opioid receptors , new
opioid modulators and agonists , the employment of optogenetics , optopharmacology , and next - generation sequencing of
opioid receptor genes and related functionality should create exciting new avenues for research and therapeutic development to treat conditions including
pain ,
opioid abuse , and
addiction . -
pubmed
INTRODUCTION : During the last decade , new
FVIII / IX concentrates have been developed for the treatment of
patients affected by
hemophilia A / B. -
pubmed
The new humanized monoclonal antibody (
MAb ) ACE910 , mimicking
FVIII function , seems to be able to reduce the
bleedings of
hemophilia A patients with inhibitors . -
pubmed
We aimed to determine the occurrence of
IgG4 - retroperitoneal fibrosis (
IgG4 -
RPF ) in a nationwide study on
patients with newly diagnosed
IRPF , and to compare histopathological , imaging , and clinical features in the
IgG4 - RPF and non -
IgG4 - RPF subsets . -
pubmed
Nineteen ( 45 % ) met the criteria for
IgG4 -
RPF , seven with definite and 12 with possible
IgG4 -
RPF , while 23 had non -
IgG4 - RPF . -
pubmed
Arterial
hypertension ( p = 0.037 ) and
periaortic fibrosis ( p = 0.024 ) were more common in
IgG4 - RPF vs non -
IgG4 - RPF . -
pubmed
There was a positive correlation between tissue
IgG4 - positive plasma cells and eosinophil cell count in
patients with
IgG4 -
RPF ( rho = 0.50 , p = 0.043 ) . -
pubmed
Conclusion : Forty - five per cent of this nationwide study population with newly diagnosed
IRPF could be reclassified with
IgG4 - RPF . -
pubmed
The association between high numbers of
IgG4 - bearing plasma cells and histopathological features of
IgG4 - RPF supports
IgG4 - bearing plasma cells with a perturbed distribution between
IgG4 and total
IgG being implicated in the pathogenesis of
IgG4 -
RPF . -
pubmed
SOX11 hypermethylation as a
tumor biomarker in
endometrial cancer . -
pubmed
We previously reported that
SOX4 is overexpressed in
endometrial cancer and that it partially contributes to hypermethylation of miR-129 - 2 and miR-203 . -
pubmed
The methylation level of the
SOX11 locus was correlated with clinicopathologic factors in primary endometrial
tumors and in TCGA endometrial cohort . -
pubmed
COBRA assays indicated that hypermethylation of
SOX1 ,
SOX2 ,
SOX11 ,
SOX14 ,
SOX15 ,
SOX17 , and
SOX18 was present in
endometrial cancer cell lines and not in the
normal control . -
pubmed
Moreover , aberrant DNA methylation of
SOX11 was detected in the majority of
endometrioid endometrial
carcinomas ( n=114 ) and none of the 22 adjacent
normal endometrial samples ( P<0.0001 ) . -
pubmed
The methylation status of
SOX11 associated significantly with microsatellite instability and
MLH1 methylation in endometrial
tumors ( P<0.0001 ) , and this finding was validated in TCGA endometrial cohort . -
pubmed
Furthermore ,
SOX11 was not hypermethylated in serum DNA from early stage
endometrial cancer patients . -
pubmed
This study found that hypermethylation of
SOX11 is common in endometrial
carcinomas and strongly associates with microsatellite instability and
MLH1 methylation . -
pubmed
Carrying a 112 bp - segment in
Helicobacter pylori dupA may associate with increased risk of
duodenal ulcer . -
pubmed
Among different investigated virulence factors ,
duodenal ulcer promoting gene A (
dupA ) has been found to be associated with
duodenal ulcer (
DU ) , but its effect was different in various geographical regions . -
pubmed
pylori
dupA may serve as the first detected biomarker for the early detection of
DU in patients admitted to hospitals . -
pubmed
KRAS alterations were present in 30 % of
polyps . -
pubmed
The
Ras - like GTPases
RalA and
RalB act downstream of
Ras in
malignant peripheral nerve sheath tumors . -
pubmed
Non - targeted and targeted metabolomics were applied on both lean ss -
Phb2-/-
mice ( ss - cell - specific
prohibitin-2 knockout ) and
obese db / db
mice (
leptin receptor mutant ) , two distinct
mouse models requiring neither chemical nor diet treatments to induce spontaneous decline of functional ss - cell mass promoting progressive
diabetes development . -
pubmed
Unraveling
FATP1 , regulated by
ER - beta , as a targeted
breast cancer innovative therapy . -
pubmed
Recently , our team has shown that
FATP1 has a pivotal role in FA transfer between
breast cancer cells (
BCCs ) and
non - cancerous cells in the microenvironment . -
pubmed
We aimed to investigate the role of
FATP1 in
BCCs and also to explore if
FATP1 inhibition is a promising therapeutic strategy . -
pubmed
In
patients ' data , we showed a higher expression of
FATP1 /
SLC27A1 in
TNBC , which correlated with a significant decreased overall survival ( OS ) . -
pubmed
In vitro , we verified that FA and
estradiol stimulated
FATP1 /
SLC27A1 expression in
BCCs . -
pubmed
Additionally , experiments with
estradiol and
PHTPP (
ER - beta antagonist ) showed that
estrogen receptor - beta (
ER - beta ) regulates
FATP1 /
SLC27A1 expression , the uptake of FA and cell viability , in four
BCC lines . -
pubmed
Our study , unraveled
FATP1 as a putative therapeutic target in
breast cancer (
BC ) . -
pubmed
Efficacy of
xanthine oxidase inhibitor for
chronic kidney disease patients with
hyperuricemia . -
pubmed
CONCLUSIONS : In this study ,
XO inhibitors did not significantly reduce the uPCR in
chronic kidney disease stage 3 and 4
patients with
hyperuricemia . -
pubmed
BACKGROUND :
Fingolimod (
FTY ) applied as treatment regimen of
relapsing - remitting multiple sclerosis (
RRMS ) induces downregulation of
sphingosine-1 - phosphate receptors on the lymphocytes . -
pubmed
As a result
CC chemokine receptor type 7 (
CCR7 ) expressing lymphocytes are retained within the peripheral lymph nodes thus suppressing their accumulation into the cerebrospinal fluid of
multiple sclerosis (
MS )
patients and hampering disease progress . -
pubmed
Unfortunately ,
MS patients treated with
FTY suffer from an increased incidence of
varicella - zoster virus ( VZV ) infections which has been associated with a decrease of
VZV immediate early 63 (
IE63)-specific T - cell immunity . -
pubmed
Additionally , a strong correlation between VZV - specific
IgG serum titers and the percentage of
RRMS patients with detectable
VZV - specific T cells was observed ( r = 0.985 ) . -
pubmed
Most remarkably ,
FTY - treated
RRMS patients presented a shift in the predominant
CD8 + T cell - mediated antigen - response from immediate early (
IE62 ) to
early virus antigens (
ORF26 ) six months after treatment in parallel to a decrease of
VZV - specific
CD4 + T - cell immunity . -
pubmed
ORF26 - specific CD8 + T cells still dominated the
VZV - specific cellular immunity at month 12 after
FTY - treatment start and in LT
FTY - treated
MS patients . -
pubmed
In a
RRMS patient an increase of
VZV - specific
CD4 + T cells at VZV - reactivation accompanied with a four - fold increase of a VZV - specific
IgG titer was detected which might indicate an important role in cellular immune control of
VZV - infections . -
pubmed
Hereby , we report a 71 - year - old female with
seronegative rheumatoid arthritis who presented with massive
splenomegaly ,
pancytopenia , and positivization of antibodies against double - stranded deoxyribonucleic acid ( dsDNA ) after initiation of the
anti - tumor necrosis factor (
TNF ) golimumab . -
pubmed
EBV - associated
LPDs are described after initiation of other anti -
TNF agents , such as infliximab , but no reports of golimumab - associated
EBV LPD are found in the literature . -
pubmed
Urethral meatus stricture BOO stimulates bladder smooth muscle cell proliferation and pyroptosis via
IL-1beta and the
SGK1 -
NFAT2 signaling pathway . -
pubmed
Compared with chronic obstruction , acute obstruction led to increased expression of
proliferating cell nuclear antigen and
interleukin-1beta , which are markers of proliferation and
inflammation , respectively . -
pubmed
RESULTS : In the presence of
tPA , 28 - day TP inhibited
tPA - induced
coagulopathy as effectively as WB . -
pubmed
Efficacy of Pembrolizumab Monotherapy in
Patients With or Without Brain Metastases From Advanced
Non - Small Cell Lung Cancer With a
PD - L1 Expression > = 50 . -
pubmed
The authors conducted a multicenter retrospective study on the outcome of
programmed death - ligand 1 tumor proportion score>=50 % advanced
non - small cell lung cancer patients treated with first - line pembrolizumab according to the presence / absence of
brain metastases . -
pubmed
Pembrolizumab has activity against
brain metastases from
non - small cell lung cancers with
programmed death - ligand 1>=50 % . -
pubmed
ATP - Sensitive Potassium Channels Mediate the Cardioprotective Effect of
Panax notoginseng Saponins against
Myocardial Ischaemia -
Reperfusion Injury and Inflammatory Reaction . -
pubmed
Human Diversity of
Killer Cell Immunoglobulin - Like Receptors and
Human Leukocyte Antigen Class I Alleles and
Ebola Virus Disease Outcomes . -
pubmed
We investigated the genetic profiles of
killer cell immunoglobulin - like receptors (
KIRs ) in
Ebola virus - infected patients . -
pubmed
We studied the relationship between
KIR -
human leukocyte antigen (
HLA ) combinations and the clinical outcomes of patients with
Ebola virus disease (
EVD ) . -
pubmed
We genotyped
KIRs and
HLA class I alleles using DNA from uninfected controls ,
EVD survivors , and persons who died of
EVD . -
pubmed
The activating
2DS4 - 003 and inhibitory
2DL5 genes were significantly more common among persons who died of
EVD ;
2DL2 was more common among survivors . -
pubmed
Our findings highlight the importance of innate immune response against
Ebola virus and show the association between
KIRs and the clinical outcome of
EVD . -
pubmed
Relation of
insulin receptors to
insulin resistance . -
pubmed
Utilizing large adipocytes from adult
rats and small fat cells from young
rats , we have conducted a series of in vitro experiments in an attempt to determine the cellular alteration(s ) responsible for the
insulin resistance associated with
obesity . -
pubmed
It has been proposed that altered
insulin - receptor interaction underlies the
insulin resistance of
human obesity . -
pubmed
Thus , the initial step in
insulin action is unaltered in
human obesity . -
pubmed
Virus isolation and determination of
serum transaminase activity in 237
patients under one year of age were undertaken to clarify the etiologic significance of primary
infection with cytomegalovirus (
CMV ) in infancy . -
pubmed
In contrast ,
CMV was recovered from 14 % ( 18/127 ) and 13 % ( 18/141 ) of infants with normal S - GOT and
S - GPT values . -
pubmed
Correlation between
complement - fixing antibody and
liver involvement , however , was not significant , probably because of the influence by maternal antibody . -
pubmed
The examination of the presence of Ph chromosome and of the fused gene
BCR -
ABL in patients with
chronic myeloid leukemia (
CML ) is significant for the precise diagnosis and in some cases for the prognosis of the disease . -
pubmed
We examined peripheral blood for the presence of
BCR -
ABL fused gene by polymerase chain reaction ( PCR ) in eight
patients with
CML consecutively cytogenetically studied before and after the bone marrow transplantation and in two
patients treated with
interferon . -
pubmed
After 2 weeks , the fish were exposed to severe environmental
hypoxia ( final water
oxygen partial pressure , PWO2 = 25 - 45 Torr , reached within 20 min ) , to assess the impact of the experimentally induced
alkalosis , and hence increased
haemoglobin -
oxygen ( Hb -
O2 ) affinity , on various aspects of the
hypoxic response . -
pubmed
Characterization of the defect in the
Na (+)- phosphate transporter in
vitamin D - resistant
hypophosphatemic mice . -
pubmed
The cause of the
hypophosphatemia is thought to be secondary to a defect in the renal and/or intestinal
Na (+)- phosphate transporter . -
pubmed
The effects of
interferon - alpha on the proliferation of
CML progenitor cells in vitro are not related to the precise position of the M - BCR breakpoint . -
pubmed
We investigated the effects of brief ( 2 h ) and continuous exposure to recombinant
interferon - alpha ( 2a ) (
rIFN - alpha ) on the proliferation of primitive ( blast colony - forming cells ,
Bl - CFC ) and committed myeloid progenitor cells (
BFU - E and GM - CFC ) derived from blood and bone marrow of
patients with
chronic myeloid leukaemia (
CML ) and normal subjects . -
pubmed
No differences were detected in the proliferation of
CML or normal Bl - CFC and GM - CFC exposed to
rIFN - alpha . -
pubmed
We conclude that ( 1 )
rIFN - alpha does not have a significant
leukaemia - specific effect on the progenitor cells detected in these assays , and ( 2 ) the sensitivity of
CML GM - CFC to
rIFN - alpha is independent of the type of
BCR /
ABL message present in the cells . -
pubmed
Removal of exposed , terminal
sialic acid ( SA ) from
carbohydrate chains N - glycosidically linked to
asparagine residues of highly pure
human C5 with
bacterial sialidase increased C - mediated
hemolysis of antibody - sensitized
sheep E maximally 2.77 - fold . -
pubmed
Differences in
c - myc and
pvt-1 amplification in SEWA
sarcoma sublines selected for adherent or non - adherent growth . -
pubmed
Enhanced peripheral and splanchnic
insulin sensitivity in
NIDDM men after single bout of exercise . -
pubmed
We studied
glucose metabolism in non -
insulin - dependent
diabetic (
NIDDM )
men with and without glycogen - depleting cycle exercise 12 h beforehand and have compared the results to our previous data in lean and
obese subjects . -
pubmed
The MCR of
glucose during both
insulin infusions was reduced in
NIDDM compared with lean
subjects but was very similar to that in
obese nondiabetics . -
pubmed
The presence of
viral antigen in the cells was determined by quantitative indirect immunofluorescence assays using a working dilution of 1:20 of a serum from an
AIDS patient as the immune serum . -
pubmed
In contrast , highly purified native
C5 induced no evidence of
pulmonary inflammation , even at the highest injection doses studied . -
pubmed
The RIA for
MFGM - gp 70 showed that the amount of antigen shed was much higher in supernatants from
normal mammary epithelial cells compared with their malignant counterparts grown in primary culture and with those from established cell lines of malignant mammary epithelial cells . -
pubmed
In this study , the antithrombotic properties of intact high - affinity heparin ( Mr = 15,000 ) and of two heparin fragments ( h16 , a 16 - monosaccharide fragment , with Mr = 4,300 , and h12 , a 12 - monosaccharide fragment , with Mr = 3,200 ) and of their functional covalent stoichiometric complexes with
human AT were compared in a
venous thrombosis stasis model in
rabbits . -
pubmed
Staining for myofibrillar ATPase revealed that all well - differentiated
ALD - derived muscle fibres were of the beta ' type , while
PLD - derived fibres were of beta and
beta R types . -
pubmed
All 10 were young ( mean 12 years ) , had no serum
alpha - fetoprotein , and no underlying
cirrhosis ; all had a longer survival compared with
patients without increased serum unsaturated
vitamin B12 binding capacity in the study . -
pubmed
Seven of the 10
patients had
fibrolamellar hepatocellular carcinoma , a recently recognised histological variant , which was found in only one young
patient without increased serum unsaturated
vitamin B12 binding capacity and no
alpha - fetoprotein among the remaining 97 . -
pubmed
Increased serum unsaturated
vitamin B12 binding capacity may be of considerable help in diagnosis , prognosis , and monitoring treatment of this well - defined group of
patients with
hepatocellular carcinoma but no
alpha - fetoprotein . -
pubmed
Under these conditions , the average
glucose infusion rate ( M ) is an index of
glucose metabolic rate , the average
insulin response ( I ) is an index of beta cell responsiveness to
hyperglycemia , and the M / I ratio is an index of
insulin sensitivity . -
pubmed
Enterotoxigenic
Escherichia coli and other gram - negative bacteria of
infantile diarrhea : surface antigens ,
hemagglutinins ,
colonization factor antigen , and loss of enterotoxigenicity . -
pubmed
Most populations of
human leukemic
acute myeloblastic leukemia (
AML ) cells express
c - Kit on their surface and respond to
Kit ligand (
KL ) in culture . -
pubmed
The model will be useful for studying the progression of
leukemia in vivo and testing whether interruption of the interaction of
Kit and
KL can affect the growth of leukemic cells . -
pubmed
CTLA-4 gene polymorphism associated with
Graves ' disease in a Caucasian population . -
pubmed
The
CTLA-4 gene or a closely associated gene ( including
CD28 ) confers susceptibility to
GD . -
pubmed
Neurasthenic fatigue , chemical sensitivity and
GABAa receptor toxins . -
pubmed
Following observation of
fatigue syndromes in
people who have been occupationally exposed to pesticides and insecticides which exert their toxicity through the
GABAa receptor , we have formulated the hypothesis that
fatigue syndromes in general may be secondary to altered sensitivity of the
GABAa receptor . -
pubmed
avium to
Tat protein in the presence of
IL-6 enhanced the growth of
AIDS - associated strains . -
pubmed
Association between
lipoprotein ( a ) and progression of
coronary artery disease in middle - aged men . -
pubmed
The association between
lipoprotein ( a ) (
Lp [ a ] ) and progression of
coronary artery disease (
CAD ) compared with other serum lipids was evaluated in 104
patients with angiographically proven
coronary atherosclerosis . -
pubmed
Patients with or without previous
myocardial infarction ( 70 vs 34 ) did not differ in
Lp ( a ) levels ( median 9.15 vs 14.25 mg / dl ) . -
pubmed
Patients with
Lp ( a ) & gt ; 25 mg / dl were younger than patients with
Lp ( a ) & lt ; or = 25 mg / dl ( 52 vs 55 years ; p & lt ; 0.03 ) , indicating a connection between
Lp ( a ) and the development of premature
CAD.(ABSTRACT TRUNCATED AT 250 WORDS ) -
pubmed
The
p53 tumor suppressor limits cellular proliferation by inducing either G1 arrest or apoptosis , depending on the cellular context . -
pubmed
Camptothecin and minor - groove binder hybrid molecules : synthesis , inhibition of
topoisomerase I , and anticancer
cytotoxicity in vitro . -
pubmed
In contrast , in the case of the cell lines
SKOV3 and
HT29 there was a general correlation between the better
topoisomerase inhibitors and their cell
cytotoxicities . -
pubmed
During the acute and subacute stage , the diagnosis of luminal
thrombus can be difficult , because signal ambiguities exist between
hemoglobin breakdown products and flow effects and adjacent fat tissues . -
pubmed
Aromatase is a
cytochrome P450 isozyme , whose inhibition is known to be therapeutically relevant in the treatment of the
breast cancer . -
pubmed
Neuropeptide Y inhibition of
calcium channels in
PC-12 pheochromocytoma cells . -
pubmed
We previously demonstrated , using
rat PC-12 pheochromocytoma cells differentiated to a sympathetic neuronal phenotype with
nerve growth factor (
NGF ) , that
neuropeptide Y ( NPY ) inhibits
catecholamine synthesis as well as release . -
pubmed
Acute myocardial infarction with large bilateral intracoronary
thrombi in a young patient with the
prothrombin 20210 G-->A mutation . -
pubmed
A genetic variation in the 3'-UT region of the
prothrombin gene , a G to A mutation at nucleotide 20210 , has been associated recently with increased risk of
acute myocardial infarction . -
pubmed
Changes in the expression of
syndecan-1 in the
colorectal adenoma - carcinoma sequence . -
pubmed
Tumour development in the large bowel is associated with loss of normal epithelial adhesion and altered patterns of expression of cell adhesion molecules , possibly including
syndecan-1 . -
pubmed
To evaluate changes in
syndecan-1 expression during the development of
colorectal neoplasia , 59
adenomas and 20
carcinomas arising from
adenomas were investigated by immunohistochemistry . -
pubmed
Staining of
syndecan-1 and
E - cadherin was uniform in
normal colorectal epithelial cells , and located at the basolateral surface . -
pubmed
Similarly , there was a significant reduction of both
molecules in
carcinomas compared with associated
adenomas (
syndecan-1 P = 0.00003 ;
E - cadherin P = 0.002 ) . -
pubmed
Our results support these findings and indicate that disruption of cell - matrix adhesion is critical in colorectal
carcinogenesis , probably preceding changes in the purely homotypic cell - cell adhesion mediated by
E - cadherin . -
pubmed
MHC class Ia - deficient
mice ( H2 Kb-/- Db-/- ) inoculated with the intracellular pathogen
Listeria monocytogenes ( LM ) displayed a three- to fourfold expansion of splenic CD8 + T cells 6 days following
infection . -
pubmed
In vivo analysis showed that B6 and
Kb-/- Db-/-
mice clear LM from the spleen and liver rapidly with similar kinetics , whereas TAP.1-/-
mice , which are deficient in
class Ia and Ib molecules , clear LM slowly upon
infection . -
pubmed
Thus , class Ia - deficient
animals have a CD8 + T cell repertoire capable of recognizing both
class Ia and class Ib molecules and can generate protective immunity to
LM . -
pubmed
Levels of chemotactic
cytokines , such as
interleukin ( IL )- 8 , and
monocyte chemotactic protein ( MCP )- 1 and levels of pro - inflammatory
cytokines , such as
tumor necrosis factor ( TNF )- alpha ,
interleukin ( IL )- 1beta and
IL-6 , elevated in
pleural effusion , and peak
IL-1beta and
IL-6 levels tended to be higher in clinical responders than non - responders . -
pubmed
Modulation of immune function by dietary
lectins in
rheumatoid arthritis . -
pubmed
By eliminating dietary elements , particularly
lectins , which adversely influence both enterocyte and lymphocyte structure and function , it is proposed that the peripheral antigenic stimulus ( both pathogenic and dietary ) will be reduced and thereby result in a diminution of disease symptoms in certain
patients with
RA . -
pubmed
[ Polymorphism of the
vitamin D receptor and
bone disease after renal transplantation ] . -
pubmed
Delayed treatment with
polynitroxyl albumin reduces
infarct size after
stroke in
rats . -
pubmed
Human immunodeficiency virus type 1 (
HIV-1 ) isolates from 50 plasma specimens were analyzed for phenotypic susceptibility to licensed
reverse transcriptase inhibitors and
protease inhibitors by the Antivirogram and PhenoSense
HIV assays . -
pubmed
Cardiac overexpression of
A1 - adenosine receptor protects intact
mice against
myocardial infarction . -
pubmed
Previous studies have shown that high - level ( 300 - fold normal ) cardiac overexpression of
A1 - adenosine receptors (
A1 - ARs ) in
transgenic ( TG ) mice protects isolated hearts against
ischemia - reperfusion injury . -
pubmed
For these studies , we therefore selected a line of TG
mice that overexpresses the
A1 - AR at more moderate levels ( 30 - fold normal ) , which affords cardioprotection in the isolated heart while minimizing
bradycardia and
arrhythmia during
ischemia in intact
mice . -
pubmed
Wild - type ( WT ; n = 10 ) and moderate - level
A1 - AR TG ( n = 10 )
mice underwent 45 min of
left anterior descending coronary artery occlusion , followed by 24 - h reperfusion . -
pubmed
Cardiac overexpression of
A1 - ARs reduces infarct size by 40 % and preserves cardiac function in intact
mice after
MI . -
pubmed
Integrated effects of multiple modulators on
human liver
glycogen phosphorylase a. Hepatic
glucose production is increased in
people with
type 2 diabetes . -
pubmed
Immunocytochemical Localization of
Glucose Transporter-2 (
GLUT-2 ) in Pancreatic Islets and
Islet Cell Tumors . -
pubmed
Using immunocytochemical staining , normal pancreases and 27 cases of
islet cell tumors , including
insulinomas ,
gastrinomas ,
glucagonomas , pancreatic polypeptide - omas ( PPomas ) , and a nonfunctioning islet cells
tumor , were systematically stained for four different pancreatic hormones ,
gastrin , and
GLUT-2 . -
pubmed
Among
islet cell tumors ,
insulinomas stained less strongly for
GLUT-2 than normal beta - cells from the adjacent normal pancreas . -
pubmed
Even nonfunctioning islet cell
tumors were weakly stained for
GLUT-2 . -
pubmed
The positive staining for
GLUT-2 observed for islets cells and all
islet tumors is consistent with the notion that all pancreatic islet cells and
islet cell tumors utilize
glucose as a major fuel , requiring transporter - facilitated diffusion of
glucose into the cells of normal organ and their
tumors . -
pubmed
alpha-2 - macroglobulin (
alpha-2 - M ) , a
plasma proteinase inhibitor , plays an important role in the pathogenesis of
lung inflammation . -
pubmed
The purpose of this study was to develop a sensitive ELISA assay for
rabbit alpha-2 - M to allow us to define the role of this protein in a
rabbit model of
lung inflammation / injury . -
pubmed
With these antibodies , we developed two ELISA assays which were used to determine the concentration of
alpha-2 - M in the lung fluids from
rabbits with
lung injury . -
pubmed
[ Effects of nao - yi - an granule on the intercellular expression of
IL-6 in the experimental intracerebral
hemorrhagic brain of
rats ] . -
pubmed
OBJECTIVE : To define the cellular localization of
IL-6 and the effects of the traditional Chinese medicine complex nao - yi - an granule ( NYA ) on the intercellular expression of
IL-6 in the experimental
intracerebral hemorrhagic (
ICH ) brain of
rats , so as to investigate the efficacy mechanisms of NYA on
ICH . -
pubmed
METHODS :
ICH rat models were established by stereotaxically injecting 0.4 U
type VII collagenase into the right globus pallidus ( GP ) . -
pubmed
RESULTS : Microglial activation was detected from 6 h to 4 d after
ICH in the
hematoma region , and reactive astrocytes were found from 6 h to 7 d after
ICH around the
hematoma region ; there was an up - regulation of
IL-6 in the
hematoma at 6 h after
ICH ; it reached its peak at 12 h , and disappeared on 7 d. CONCLUSION : The major sources of
IL-6 - positive protein were neurons and the activated microglia in the brain of
ICH rats . -
pubmed
Sulfa resistance and
dihydropteroate synthase mutants in recurrent
Pneumocystis carinii pneumonia . -
pubmed
The
DHPS genotype was analyzed in
AIDS patients who had two separate episodes of
P. - pubmed
Effect of
epoxide hydrolase polymorphisms on chromosome aberrations and risk for
lung cancer . -
pubmed
Therefore , we have investigated the association of two polymorphisms at exons 3 and 4 of the
mEH gene with the development of
lung cancer in 110
patients and 119 matched controls . -
pubmed
In addition , we have investigated the relationship between the different
mEH alleles and the frequency of chromosome aberrations ( CA ) , as an approach to understand the role of genetic susceptibility on
cancer risk . -
pubmed
In conclusion , the CA data provides evidence to support that susceptibility
mEH alleles are significantly involved with the development of
lung cancer from cigarette smoking . -
pubmed
[
Phosphatase index in the differential diagnosis of
ascites ] . -
pubmed
RESULTS : T - cell positive
patients had a shorter duration of
diabetes ( 6.7+/-2.5 years ) than T - cell negative
patients ( 9.2+/-5.0 years , p=0.011 ) and lower
albumin excretion rate , but they had a similar glomerular filtration rate and blood pressure . -
pubmed
Response of the
megaloblastic anaemias of pregnancy to
animal protein factor ; preliminary report . -
pubmed
We show that macrophages from
X - linked immunodeficient (
XID )
mice lacking functional
Btk can not generate efficient bursts of reactive
oxygen intermediates ( ROIs ) . -
pubmed
Pharmacogenetics of
dopamine receptors and response to antipsychotic drugs in
schizophrenia -- an update . -
pubmed
Nociceptin , a 17 amino acid opioid - like peptide that has an inhibitory effect on synaptic transmission in the nervous system , is involved in learning , memory , attention , and emotion and is also implicated in the perception of
pain and visual , auditory , and olfactory functions . -
pubmed
Effect of
hepatic lipase -514C->T polymorphism and its interactions with
apolipoprotein C3 -482C->T and
apolipoprotein E exon 4 polymorphisms on the risk of
nephropathy in chinese
type 2 diabetic patients . -
pubmed
Patients with
diabetic nephropathy have increased plasma
triglycerides and reduced activity of
hepatic lipase (
HL ) , which hydrolyzes
triglycerides . -
pubmed
We hypothesized that the HL -514C-->T polymorphism , which reduces
HL expression , and its interactions with polymorphisms in
apolipoprotein ( apo ) E and
apoC3 increase the risk of
diabetic nephropathy . -
pubmed
RESEARCH DESIGN AND METHODS : In a case - control study involving 374 Chinese
type 2 diabetic patients with and 392 without
diabetic nephropathy , we genotyped the HL -514C-->T ,
apoE exon 4 , and
apoC3 -482C-->T polymorphisms . -
pubmed
Adjustment by multiple logistic regression for
hypertension ,
triglycerides , sex , non -
HDL cholesterol , BMI , smoking , and
alcohol intake did not diminish the association ( OR = 1.8 , P = 0.003 ) . -
pubmed
The association between HL T+ genotypes and
diabetic nephropathy appeared stronger in
diabetic patients with
apoC3 -482 non - TT genotypes ( OR = 1.9 , P = 0.003 ) or
apoE epsilon2 or epsilon4 alleles ( OR = 2.2 , P = 0.005 ) . -
pubmed
Subjects with
HL TT exhibited trends toward increased
triglyceride and non -
HDL cholesterol levels compared with CC carriers . -
pubmed
,
hyperglycemia ) ,
lipid abnormalities may damage the kidneys and endothelium , where reduced binding sites for
lipases may precipitate a vicious cycle of
dyslipidemia ,
proteinuria , and
nephropathy . -
pubmed
Pravastatin appears to be the best
HMG - CoA reductase inhibitor for organ transplant recipients because of its lesser potential to interact with
cyclosporin and hence cause
myositis , which may thus allow higher doses to be used . -
pubmed
DE-310 , a macromolecular prodrug of the
topoisomerase - I - inhibitor
exatecan (
DX-8951 ) , in
patients with operable
solid tumors . -
pubmed
Cystamine , an inhibitor of
transglutaminases , slows progression of
Huntington ' s disease in the
murine model by approximately 20 % . -
pubmed
Considering that MA could be acting as an immunomodulator preventing the development of
herpetic stromal keratitis in
mice , we also examined an eventual effect of
CDM on
NF - kappaB signaling pathway . -
pubmed
G - CSF could worsen
anaemia in
breast cancer . -
pubmed
Bone mineral density , bone turnover , and
osteoprotegerin in depressed
women with and without
borderline personality disorder . -
pubmed
Therefore , we examined bone density , markers of bone turnover , and proinflammatory
cytokines in depressed
patients with and without
BPD . -
pubmed
Osteocalcin , a marker of osteoblastic activity , and crosslaps , a marker of
bone loss , were significantly different between the study groups . -
pubmed
Expression of
heat shock protein 47 in the fibrous tissue adjacent to
mouse tumour subjected to photodynamic therapy . -
pubmed
The reaction of normal fibrous tissue adjacent to
tumours subjected to photodynamic therapy ( PDT ) was investigated by assessment of the immunohistochemical expression of
heat shock protein 47 (
HSP47 ) and
proliferating cell nuclear antigen (
PCNA ) , as well as by immunoblot analysis of
procollagen type I. -
pubmed
The expression of
procollagen type I in the fibrous tissue adjacent to the
tumours was examined by immunoblot analysis at intervals of 24 and 48h after PDT . -
pubmed
The expression of
HSP47 was first detected 6h post - PDT in the
tumour - bearing
mice , but no such expression was observed in the normal
mice . -
pubmed
It was also revealed that , after PDT , the fibroblast
PCNA labeling indices at 24 , 48 , and 72h were significantly higher in both the
tumour - bearing and the normal
mice than in the control animals that did not receive PDT . -
pubmed
Furthermore ,
procollagen type I was detected in the fibrous tissue adjacent to the
tumours at 24 and 48h after PDT , but was not detected in the fibrous tissue adjacent to
tumours of
mice that did not receive PDT . -
pubmed
Therefore , the present results suggest that PDT enhances the synthesis of
collagen type I in the fibrous tissue adjacent to
NR - S1 squamous cell carcinoma in
mice , which contributes to the resultant encapsulation of such
tumours . -
pubmed
We assessed the
complement C3 and
C4 concentration ratio (
C3 / C4 ratio ) in serum as a potential measurement to predict
cardiovascular attacks . -
pubmed
In conclusion , increased
serum C3 / C4 ratio is a readily available and novel marker for recurrent cardiovascular events in
acute coronary syndrome . -
pubmed
Cerebral cavernomas in a family with multiple
cutaneous and uterine leiomyomas associated with a new mutation in the
fumarate hydratase gene . -
pubmed
TACE : a new target in
epidermal growth factor receptor dependent
tumors . -
pubmed
This review focuses on a subset of these proteins , which are cleaved by
tumor necrosis factor alpha - converting enzyme (
TACE)/
ADAM17 , and on their role in
cancer . -
pubmed
A novel " pearl box "
cataract associated with a mutation in the
connexin 46 (
GJA3 ) gene . -
pubmed
PURPOSE : To undertake mutation screening in the
connexin 46 (
GJA3 ) gene in seven
congenital cataract families of Indian origin . -
pubmed
These findings thus expand the mutation spectrum of the
GJA3 in association with
congenital cataract . -
pubmed
[ Clinical significance of
FLT3 internal tandem duplication in
acute myeloid leukemia with
chromosome abnormality ] . -
pubmed
This study was to explore the clinical significance of
FLT3 internal tandem duplication (
FLT3 / ITD ) in
acute myeloid leukemia (
AML ) with
chromosome abnormality . -
pubmed
Using genomic PCR and sequencing ,
FLT3 /
ITD mutation in
AML patients with or without
chromosome abnormity were examined . -
pubmed
In 79 samples without
chromosome abnormality ,
FLT3 gene expression was detected in 56 samples , the positive rate was 70.89 % . -
pubmed
Clinical data showed that the difference was no statistically significant ( p & gt ; 0.05 ) in leukocyte counting and
Hb assay in peripheral blood as well as leukocyte ratio in bone marrow of these two groups with or without
chromosome abnormality . -
pubmed
Most
FLT3 /
ITD mutation patients with or without
chromosome abnormality died in short time , the difference of death rate was not statistically significant between these two groups ( p & gt ; 0.05 ) while the life span of
FLT3 /
ITD mutation patients with
chromosome abnormality was even shorter than the other . -
pubmed
It is concluded that prognosis is relatively poor in
FLT3 /
ITD mutation patients with
chromosome abnormality . -
pubmed
FLT3 /
ITD mutation may be an important marker for poor prognosis of
AML . -
pubmed
CAP ( 10mg / kg body weight ) pretreatment decreased lung mitochondrial
LPO and augmented the activities of enzymic , non - enzymic antioxidants ,
citric acid cycle enzymes and respiratory chain enzymes to near normalcy revealing its chemoprotective function during
B ( a ) P induced
lung cancer . -
pubmed
The role of cyclase activating (
CAP ) and
cyclase inhibiting ( CIP ) parathormone fractions in the assessment of bone metabolism disturbances in
women with
hyperprolactinemia of various origin . -
pubmed
The reason is thought to be connected with
hypogonadism due to
PRL excess and the role of other hormones like
PTH and
PTH - rP. -
pubmed
There is no data on the influence of
PTH fractions (
CAP and CIP ) on bone turnover and density in
hyperprolactinemia . -
pubmed
The aim of the study was to assess the influence of
PTH and its fractions on bone metabolism in
hyperprolactinemia of various origin . -
pubmed
RESULTS : In
patients with functional
hyperprolactinemia i -
PTH and
CAP levels were lower than in controls . -
pubmed
CAP /
CIP ratio was higher in
patients with
prolactinoma than in
patients with
functional hyperprolactinemia and controls . -
pubmed
CONCLUSIONS : There is no direct benefit from the assessment of parathormone fractions and
CAP / CIP ratio in the prognosis of bone metabolism changes in
hyperprolactinemia of various origin . -
pubmed
Effects of low - dose
parathyroid hormone on bone mass , turnover , and ectopic osteoinduction in a
rat model for
chronic alcohol abuse . -
pubmed
Parathyroid hormone (
PTH ) is used clinically in
osteoporotic patients to increase bone mass by enhancing bone formation . -
pubmed
Based on the
animal model , our findings suggest that
alcohol consumption could impair the beneficial effects of
PTH therapy in
osteoporosis . -
pubmed
His initial laboratory examination showed
leukocytosis ,
eosinophilia , and elevated
C - reactive protein . -
pubmed
Complement fixation for
coccidioidomycosis performed on a serum sample was positive at a titer of 1:2 but a latex
agglutinin test was negative . -
pubmed
Molecular network analysis of T - cell transcriptome suggests aberrant regulation of gene expression by
NF - kappaB as a biomarker for relapse of
multiple sclerosis . -
pubmed
The molecular network of 43 DEG investigated by KeyMolnet , a bioinformatics tool for analyzing molecular interaction on the curated knowledge database , showed the most significant relationship with aberrant regulation of gene expression by the
nuclear factor - kappa B (
NF - kappaB ) in T cells during
MS relapse . -
pubmed
These results support the logical hypothesis that
NF - kappaB plays a central role in triggering molecular events in T cells responsible for induction of acute relapse of
MS , and suggest that aberrant gene regulation by
NF - kappaB on T - cell transcriptome might serve as a molecular biomarker for monitoring the clinical disease activity of
MS . -
pubmed
Transforming growth factor - beta signaling and
cancer : the 28th Sapporo Cancer Seminar , 25 - 27 June 2008 . -
pubmed
The 28th Sapporo Cancer Seminar was held on 26 - 27 June 2008 at the Hokkaido University Conference Hall , focusing on
transforming growth factor ( TGF )- beta signaling and
cancer . -
pubmed
More than 150 scientists participated in the seminar , and it provided a great deal of information on the role of
TGF - beta signaling in carcinogenesis and
tumor metastasis . -
pubmed
The possible use of
TGF - beta antagonists for treatment of
cancers was also discussed at the seminar . -
pubmed
The efficacies of other novel targeted inhibitors such as
deacetylase inhibitors and
heat shock protein 90 inhibitors in the treatment of
gliomas are also discussed , as well as new combination therapies . -
pubmed
[ The polymorphism of
cytochrome P ( 450 ) 2C19 gene in
patients with
invasive fungal infections . ] -
pubmed
OBJECTIVE : To investigate the polymorphism profile of
cytochrome P ( 450 ) 2C19 (
CYP2C19 ) in Chinese
patients with invasive
fungal infections . -
pubmed
METHODS : Two major single
nucleotide polymorphism loci of the
CYP2C19 gene (
CYP2C19 * 2 and
CYP2C19 * 3 ) were genotyped with PCR and restriction fragment length polymorphism ( PCR - RFLP ) in 134
patients with invasive
fungal infections and 134 healthy volunteers . -
pubmed
RESULTS : In
patients with invasive
fungal infections ,
CYP2C19 * 1 ,
CYP2C19 * 2 and
CYP2C19 * 3 alleles showed frequencies of 58.2 % , 36.6 % and 5.2 % . -
pubmed
BACKGROUND : Spinal cord neurons of
ALS patients demonstrate reduced
cytochrome oxidase histochemical activity , and
ALS spinal cord tissues have increased mitochondrial DNA ( mtDNA ) point mutations and depleted mtDNA levels . -
pubmed
Plots of ratios of
ND4 /
ND2 and CO3 /
ND2 showed that many but not all
ALS neurons from individuals contained low ratios of these mtDNA genes , implying greater abundances of mtDNA deletions in the major arc . -
pubmed
If these anterior spinal neuron mtDNA gene deficiencies contribute to bioenergetic impairments , reduced synaptic function and increased risk of degeneration , then introduction into mitochondria and expression of intact mtDNA , now available through use of recently developed recombinant
human TFAM , may reverse the course of
ALS . -
pubmed
Oxidative stress and
amyloid - beta pathology in normal
individuals with a maternal history of
Alzheimer ' s . -
pubmed
All
subjects completed clinical neuropsychological examinations and a lumbar puncture to measure CSF levels of
amyloid - beta (
Abeta ( 40 ) ,
Abeta ( 42 ) ,
Abeta(42/40 ) ) , total and hyperphosphorylated
tau (
T - Tau and
P - Tau(231 ) ; markers of
axonal degeneration and neurofibrillary tangles , respectively ) , and
F2 - isoprostanes (
IsoP ) ( a marker of oxidative stress ) . -
pubmed
The MH
subjects showed higher
IsoP and reduced
Abeta ( 42 / 40 ) CSF levels compared with NH and with
PH ( p values < = .05 ) , whereas no differences were found between NH and
PH . -
pubmed
CONCLUSIONS : Adult children of
LOAD - affected mothers express a pathobiological phenotype characterized by
Abeta - associated oxidative stress consistent with
AD , which might reflect increased risk for developing the disease . -
pubmed
PSA and beyond : the past , present , and future of investigative biomarkers for
prostate cancer . -
pubmed
The discovery of
prostate - specific antigen (
PSA ) as a biomarker represented a major discovery in the early diagnosis and monitoring of
prostate cancer . -
pubmed
The purpose of this study is to review available data on
prostate cancer biomarkers for
prostate cancer screening and prognostication , including
prostatic acid phosphatase ,
PSA ,
PSA derivatives (
PSA density , free
PSA , pro
PSA , and
PSA kinetics ) ,
PCA3 ,
GSTP1 ,
AMACR , and other newly emerging molecular and genetic markers . -
pubmed
PEP-1 -
SOD1 protects brain from ischemic insult following asphyxial
cardiac arrest in
rats . -
pubmed
Copper ,
zinc - superoxide dismutase (
SOD1 ) is one of the major defensive mechanisms by which cells counteract the deleterious effects of ROS after
ischemia . -
pubmed
Moreover , we determined whether or not
PEP-1 -
SOD1 can protect brain from
ischemic injury in an experimental asphyxial
cardiac arrest rat model through histopathologic analysis , evaluating the levels of
malondialdehyde (
MDA ) ,
S100beta and
neuron specific enolase (
NSE ) . -
pubmed
The transduced
PEP-1 -
SOD1 significantly attenuated
cerebral ischemia - reperfusion damage , inhibited
ischemia - induced lipid peroxidation , and protected neurons in hippocampus from the damage induced by transient global ischemic insults . -
pubmed
CONCLUSIONS :
PEP-1 -
SOD1 fusion protein can be transduced into the neurons in vivo and protect the neurons from the transient global
ischemia - induced damage , suggesting
PEP-1 -
SOD1 may be used for the treatment of oxidative stress - associated disorders such as transient global
cerebral ischemia . -
pubmed
Here , we review the function of
OAT3 and
OCT3 at the BBB and BCSFB in the context of their roles in the progression of
renal failure . -
pubmed
Dermatological adverse effects during genotype-1
hepatitis C treatment with the
protease inhibitors
telaprevir and
boceprevir . -
pubmed
Hemoglobin level and survival in hemodialysis
patients with
polycystic kidney disease and the role of administered
erythropoietin . -
pubmed
Interventional trials indicate adverse outcomes when
hemoglobin & gt;13 g / dL is targeted in
patients with
chronic kidney disease (
CKD ) who receive erythropoiesis - stimulating agents ( ESAs ) . -
pubmed
It is not clear whether high - achieved
hemoglobin with minimal to no ESA administration as observed in some patients with
polycystic kidney disease (
PKD ) is also associated with poor outcomes . -
pubmed
Survival models were examined to assess the association between
hemoglobin increments and mortality in a 6 - year cohort of 2,402
PKD and 110,875 non -
PKD hemodialysis
patients across infrequent versus frequent ESA therapy defined as ESA & lt ; 25 % of cohort time versus otherwise , respectively . -
pubmed
Hence , in patients with
PKD who require infrequent ESA , incrementally higher achieved
hemoglobin including & gt ; 13.0 g / dL exhibits better survival ; this incremental survival gain of higher
hemoglobin is not observed in patients with
PKD receiving frequent ESA administration , in whom
hemoglobin concentration & gt ; 13 exhibits increased mortality . -
pubmed
Two cases with severe lethal course of
Costello syndrome associated with
HRAS p. G12C and p. G12D. -
pubmed
Heterozygous de novo germline mutations in the proto - oncogene
HRAS cause
CS . -
pubmed
Other less common lesions in
HRAS can induce a milder phenotype on the one hand and a more severe phenotype on the other broadening the spectrum of clinical manifestations in
CS - affected individuals . -
pubmed
The content of
glycated hemoglobin , a biomarker of
diabetes in
patients with
type 2 diabetes correlates with risk factors for
cardiovascular disease :
hypertension , BMI and ratio of total
cholesterol to
HDL cholesterol . -
pubmed
Therefore , increase in glycosylated
hemoglobin should be considered a predictor of
cardiovascular disease in
patients with
type 2 diabetes . -
pubmed
Relationship between the
chemokine receptor CCR5 and microglia in
neurological disorders : consequences of targeting
CCR5 on neuroinflammation , neuronal death and regeneration in a model of
epilepsy . -
pubmed
Chemokines may play a role in leukocyte migration across the blood - brain barrier ( BBB ) during
neuroinflammation and other neuropathological processes , such as
epilepsy . -
pubmed
The current review examines the relationship between
CCR5 and the microglia in different
neurological disorders and models of
CNS injury . -
pubmed
CCR5 expression is upregulated in different
neurological diseases , where it is often immunolocalized in microglial cells . -
pubmed
Consequently , targeting
CCR5 by using
CCR5 antagonists may attenuate critical aspects of neuroinflammation in different models of
neurological disorders . -
pubmed
To illustrate the interaction between
CCR5 and microglia in the CNS , we used a model of excitotoxicity , and demonstrate the intimate involvement of
CCR5 in
neuron injury and
inflammation attendant to
kainic acid ( KA)-induced
neurotoxicity . -
pubmed
CCR5 participates in
neuronal injury caused by the excitotoxin , KA , brings inflammatory cells to the sites of KA - induced
CNS injury , defines the extent of tissue loss after KA exposure and limits reparative responses . -
pubmed
Thus , therapeutic targeting of
CCR5 may allow control of potentially injurious neuroinflammatory responses , including decrease in microglial cells activation and proliferation , and facilitate neurogenic repair in
seizure - induced and , potentially , other forms of
CNS injury . -
pubmed
Here we report the case of a
patient with diffuse cutaneous
SSc who was administered anti -
interleukin-6 receptor antibody tocilizumab (
TCZ ) . -
pubmed
Pentoxifylline does not alter the concentration of
hepcidin in
chronic kidney disease patients undergoing hemodialysis . -
pubmed
INTRODUCTION :
Anemia is a frequent condition in
patients with
chronic kidney disease due to a reduction in the production of
erythropoietin . -
pubmed
Patients with
inflammation respond less well to treatment with
erythropoietin , possibly because the increased production of
hepcidin reduces the availability of
iron for hematopoiesis . -
pubmed
OBJECTIVE : The aim of this study was to analyze the effect of
pentoxifylline on
serum hepcidin in chronic hemodialysis
patients with
inflammation . -
pubmed
Moreover ,
EGCG alleviates
CD4(+ )
CD45RB(hi )
CD25(- ) T cell transfer induced
colitis with less accumulation of
CD4(+ ) T cells in the colon . -
pubmed
In conclusion , the present study reports an alternative activation of
STAT1 via
Src by
EGCG in
IFN - gamma - activated CD4 (+ ) T cells , which promotes the apoptosis of
IFN - gamma - activated CD4(+ ) T cells and contributes to the improvement of T cell - mediated
colitis . -
pubmed
Our findings suggest a novel role of
EGCG in regulating
IFN - gamma signaling and controlling
inflammation . -
pubmed
WAT showed an increase in
inflammation and ER stress and brown adipocytes suffered a brown - to - white transformation and decreased
UCP-1 expression . -
pubmed
Prostate - specific antigen - based
prostate cancer screening : Past and future . -
pubmed
Prostate - specific antigen - based
prostate cancer screening remains a controversial topic . -
pubmed
Deactivation of excitatory neurons in the prelimbic cortex via
Cdk5 promotes
pain sensation and
anxiety . -
pubmed
The intrinsic excitability of contralateral PL excitatory neurons is decreased in
chronic pain rats ; knocking down
cyclin - dependent kinase 5 reverses this deactivation and alleviates behavioural impairments . -
pubmed
The Effects of a
GLP-1 Analog on
Glucose Homeostasis in
Type 2 Diabetes Mellitus Quantified by an Integrated
Glucose Insulin Model . -
pubmed
In recent years , several
glucagon - like peptide-1 (
GLP-1)-based therapies for the treatment of
type 2 diabetes mellitus (
T2DM ) have been developed . -
pubmed
The aim of this work was to extend the semimechanistic integrated
glucose -
insulin model to include the effects of a
GLP-1 analog on
glucose homeostasis in
T2DM patients . -
pubmed
Data from two trials comparing the effect of steady - state liraglutide vs. placebo on the responses of postprandial
glucose and
insulin in
T2DM patients were used for model development . -
pubmed
Association between
hepatocellular carcinoma and
tumor necrosis factor alpha polymorphisms in South Korea . -
pubmed
AIM : To investigate associations between the
tumor necrosis factor alpha (
TNF - alpha ) -1031 T>C , -863 C>A , -857 C>T , -308 G>A , and -238 G>A polymorphisms and
HCC in Korea . -
pubmed
The association between
TNF - alpha polymorphisms and
HCC was analyzed in 157
HCC patients and 201 controls using a polymerase chain reaction - restriction fragment length polymorphism assay . -
pubmed
The
TNF - alpha genotype frequencies , genotype combinations and haplotypes were analyzed to disclose the association with
HCC . -
pubmed
RESULTS : None of the
TNF - alpha polymorphisms was significantly associated with
HCC . -
pubmed
Among them ,
TNF - alpha -1031/-857/-238 TT / CC / GA ( AOR = 18.849 , 95%CI : 2.203 - 161.246 , P = 0.007 ) ,
TNF - alpha -1031/-308/-238 TT / GG / GA ( AOR = 26.956 , 95%CI : 3.071 - 236.584 , P = 0.003 ) , and
TNF - alpha -1031/-238 TT / GA ( AOR = 21.576 , 95%CI : 2.581 - 180.394 , P = 0.005 ) showed marked association with
HCC . -
pubmed
There were five haplotypes of
TNF - alpha polymorphisms which were significantly associated with
HCC . -
pubmed
Moreover ,
HCC Okuda stage III cases with the
TNF - alpha -1031 CC genotype had better survival than those with the TT genotype ( AOR = 5.795 , 95%CI : 1.145 - 29.323 ) . -
pubmed
CONCLUSION : Although no single
TNF - alpha polymorphism is associated with
HCC in this study , some
TNF - alpha genotype combinations and haplotypes are associated with
HCC . -
pubmed
In addition ,
HCC Okuda stage III cases with the
TNF - alpha -1031 TT genotype may have a better prognosis than those with the CC genotype . -
pubmed
AIM : Previous studies showed that circulating
fibroblast growth factor-23 (
FGF23 ) is a new biomarker linked to
cardiovascular and kidney diseases . -
pubmed
The study demonstrates for the first time sex - and structure - specific changes in the response of the
thioredoxin system to
MeHg neurotoxicity and suggests that these differences in antioxidant responses might impart differential susceptibility to developmental
MeHg exposure . -
pubmed
The free light chain (
FLC ) assay is also useful in the diagnosis and therapeutic monitoring of
MM . -
pubmed
Association of polymorphisms in
PATE1 gene with
idiopathic asthenozoospermia in Sichuan , China . -
pubmed
However , the single nucleotide polymorphisms ( SNPs ) of the
PATE1 gene which contribute to
AZS were still unknown . -
pubmed
For this reason , the possible association between the single nucleotide polymorphisms of the
PATE1 gene and
idiopathic asthenozoospermia was investigated in this research . -
pubmed
The sequence analyses of the
PATE1 gene were conducted in 108
idiopathic asthenozoospermia and 106 fertile men with normospermic parameters in Sichuan , China . -
pubmed
CONCLUSIONS : These results suggested that
PATE1 variant ( A1423 G ) was probably one of the high risk genetic factors for
idiopathic asthenozoospermia among males in Sichuan , China . -
pubmed
Vitreous
Fibronectin and
Fibrinogen Expression Increased in Eyes With Proliferative
Diabetic Retinopathy After Intravitreal Anti -
VEGF Therapy . -
pubmed
Purpose : To evaluate vitreous humor ( VH ) protein expression profiles in
patients with
proliferative diabetic retinopathy (
PDR ) , with and without intravitreal injection ( IVI ) of anti -
vascular endothelial growth factor ( anti -
VEGF ) before vitrectomy . -
pubmed
Conclusions : VH
fibronectin and
fibrinogen concentrations were highest in the IVI
patients , which may promote
fibrin - fibronectin complexation and
fibrosis in eyes with
PDR . -
pubmed
Repeated vaccination with tetanus toxoid of plasma donors with pre - existing specific
IgE transiently elevates tetanus - specific
IgE but does not induce
allergic symptoms . -
pubmed
The questionnaire was administered to 219 individuals at risk of
RA on the basis of symptoms or autoantibody positivity : 74 %
rheumatoid factor and/or anticitrullinated protein antibodies positive , 26 % seronegative . -
pubmed
Prealbumin and lymphocyte - based prognostic score , a new tool for predicting long - term survival after curative resection of
stage II / III gastric cancer . -
pubmed
Although liver enzymes ,
bilirubin and
albumin demonstrated a circadian pattern , it was not associated with
fatigue . -
pubmed
Long noncoding RNA
MNX1 -
AS1 contributes to
lung cancer progression through the miR-527 /
BRF2 pathway . -
pubmed
LncRNA
MNX1 -
AS1 is proven to regulate
colon adenocarcinoma ,
cervical cancer ,
glioblastoma , and
ovarian cancer . -
pubmed
Whether
MNX1 -
AS1 participates in
lung cancer needs investigation . -
pubmed
In our research , we found that
MNX1 -
AS1 was dramatically upregulated in
lung cancer . -
pubmed
MNX1 -
AS1 upregulation indicated poor prognosis in
lung cancer patients . -
pubmed
Functionally ,
MNX1 -
AS1 promoted
lung cancer progression through regulating proliferation , migration , and invasion . -
pubmed
Taken together , our study found a novel signaling pathway , namely
MNX1 -
AS1 / miR-527 /
BRF2 axis , involved in
lung cancer progression . -
pubmed
The
CD98 Heavy Chain Is a Marker and Regulator of
Head and Neck Squamous Cell Carcinoma Radiosensitivity . -
pubmed
High
SLC3A2 mRNA expression levels are associated with poor prognosis in
patients with
head and neck squamous cell carcinoma (
HNSCC ) treated with radiochemotherapy . -
pubmed
Little is known regarding the
CD98hc protein - mediated molecular mechanisms of
tumor radioresistance . -
pubmed
EXPERIMENTAL DESIGN :
CD98hc protein expression levels were correlated with corresponding
tumor control dose 50 ( TCD50 ) in
HNSCC xenograft models . -
pubmed
Expression levels of
CD98hc and
LAT1 in
HNSCC cells were modulated by siRNA or CRISPR / Cas9 gene editing . -
pubmed
Expression levels of
CD98hc and
LAT1 proteins were examined by IHC analysis of
tumor tissues from
patients with locally advanced
HNSCC treated with primary radiochemotherapy ( RCTx ) . -
pubmed
High expression levels of
CD98hc and
LAT1 proteins were significantly correlated and associated with an increase in radioresistance in
HNSCC in vitro and in vivo models . -
pubmed
CONCLUSIONS : We found that
CD98hc - associated signaling mechanisms play a central role in the regulation of
HNSCC radioresistance and may be a promising target for
tumor radiosensitization . -
pubmed
The developmental / pathogenic contribution of the t(4;11)-resulting
MLL - AF4 ( MA4 ) and
AF4 -
MLL ( A4 M ) fusions remains unclear ;
MA4 is always expressed in patients with t(4;11)+ B - cell
acute lymphoblastic leukemia , but the reciprocal fusion
A4 M is expressed in only half of the
patients . -
pubmed
Di ( 2 - ethyl hexyl ) phthalate (
DEHP)-induced
spleen toxicity in
quail (
Coturnix japonica ) via disturbing
Nrf2 - mediated defense response . -
pubmed
Individual free
fatty acids have unique associations with inflammatory biomarkers ,
insulin resistance and
insulin secretion in healthy and gestational
diabetic pregnant women . -
pubmed
Objective : We investigated the relationships of maternal circulating individual free
fatty acids ( FFA ) with
insulin resistance ,
insulin secretion and inflammatory biomarkers during mid - pregnancy . -
pubmed
We quantitatively determined 11 FFAs , seven
cytokine / adipokine , homeostatic model assessment of
insulin resistance (
HOMA - IR ) and
C - peptide levels from the fasting blood samples that were collected at 16 weeks of gestation . -
pubmed
Results : High HOMA - IR ( p<0.001 ) and
C - peptide ( p<0.0001 ) levels were positively associated with a twofold to fourfold increased risk for developing
gestational diabetes mellitus (
GDM ) . -
pubmed
Here , we found that the
muscarinic acetylcholine receptor , cholinergic receptor ,
muscarinic 4 (
CHRM4 ) , pathway regulates BFU - E self - renewal and that pharmacological inhibition of
CHRM4 corrects
anemias of
myelodysplastic syndrome (
MDS ) , aging , and
hemolysis . -
pubmed
Moreover ,
muscarinic acetylcholine receptor antagonists corrected
anemias in
mouse models of
MDS , aging , and
hemolysis in vivo , extending the survival of
mice with
MDS relative to that of controls . -
pubmed
On the basis of these data , we propose a model of hematopoietic progenitor self - renewal through a cholinergic - mediated " hematopoietic reflex " and identify
muscarinic acetylcholine receptor antagonists as potential therapies for
anemias associated with
MDS , aging , and
hemolysis . -
pubmed
We previously reported the reduction of RNA binding protein
HuD in pancreatic beta - cells of
diabetes . -
pubmed
Downregulation of
HuD increases the number of cells with fragmented mitochondria and reduces the mitochondrial activity determined by mitochondrial membrane potential and
ATP production in
mouse insulinoma betaTC6 cells . -
pubmed
Ectopic expression of
Mfn2 in betaTC6 cells stably expressing short hairpin RNA against
HuD (
shHuD ) restores
HuD - mediated
mitochondrial dysfunction . -
pubmed
Taken together , our results suggest that
HuD regulates mitochondrial dynamics by regulating
Mfn2 level and its reduced expression leads to
mitochondrial dysfunction in pancreatic beta - cells . -
pubmed
Apold1(
apolipoprotein L domain containing 1 ) is a gene expressed by endothelial cells ; whether
Apold1 directly contributes to arterial
thrombosis has not yet been investigated . -
pubmed
Here , we assessed the effect of
Apold1 deletion on arterial
thrombus formation using an in vivo model of
carotid thrombosis induced by photochemical injury . -
pubmed
MATERIAL AND METHODS :
Apold1 knockout (
Apold1-/- )
mice and wild type ( WT ) littermates underwent
carotid thrombosis induced by photochemical injury and time to occlusion was recorded . -
pubmed
CONCLUSIONS :
Deficiency of Apold1 results in a prothrombotic phenotype , accompanied by increased
vascular TF activity , decreased
PI3K /
Akt activation and increased platelet reactivity . -
pubmed
These findings suggest
Apold1 as an interesting new therapeutic target in the context of
arterial thrombosis . -
pubmed
The findings from this study indicate that
HULC , RP11 - 314B1.2 ,
LINC00106 , and RP11 - 999E24.3 could be considered as potential therapeutic targets or prognostic biomarkers in
gastric cancer , and provide a new perspective for
cancer pathogenesis research . -
pubmed
pneumoniae
lipid - associated membrane proteins (
LAMPs ) induces
lung lesions consistent with exacerbated disease following challenge , without reducing bacterial loads . -
pubmed
We identified less / no lipid signals within the
tumor and intense
deoxy - hemoglobin (
Hb ) signals on the rim of the
tumor as unique characteristics of
malignant tumors in comparison to no
tumor region . -
pubmed
Downregulationof pregnancy - specific
beta-1 - glycoprotein 9 (
PSG9 ) in the
LOPE group was confirmed by ELISA . -
pubmed
Expressions
ofm6A RNA methylation regulatorsand their clinical predictive value in
cervical squamous cell carcinoma and
endometrial adenocarcinoma . -
pubmed
As a result , 5 m6A RNA methylation regulators (
FTO ,
HNRNPA2B1 ,
RBM15 ,
IGF2BP1 ,
IGF2BP3 ) were identified to be significantly linked to CESC
tumor status . -
pubmed
Antiplasmin concentrations after surgery : failure of
alpha 2 - antiplasmin to rise in
patients with
venous thrombosis . -
pubmed
These designations included the terms "
insulin - dependent , " " idiopathic , " "
insulin - requiring , " and "
ketosis - prone . " -
pubmed
Much progress could be accomplished , even in the absence of international standardized definitions and classification systems , provided that authors keep in mind the need to describe the major characteristics of their cases and define the sense in which they use terms such as
insulin - dependent ,
ketosis - prone ,
obese , etc . -
pubmed
Effect of
erythropoietin therapy on the red cell volume of
uraemic and non -
uraemic rats . -
pubmed
Studies were performed to determine the effect of injecting repeated doses of
erythropoietin ( Ep ) on the red cell volume of chronically
uraemic rats and on that of non - uraemic sham operated ones . -
pubmed
[ Change in the
amylase activity and microflora in the bile in
cholecystitis ] . -
pubmed
[
Aminoacids in the
keratin of skin , hair and nails in
psoriasis cases ( author 's transl ) ] . -
pubmed
Comparative study of effects of
cyclosporins A and G on
collagen arthritis in
mice . -
pubmed
The effects of the immunosuppressive agents
cyclosporin G (
CsG ) and
cyclosporin A (
CsA ) on
collagen arthritis were compared in
mice . -
pubmed
When administered subcutaneously daily on days 0 - 13 after immunization with
type II collagen ,
CsG and
CsA were both capable of suppressing the development of
collagen arthritis in
mice as well as the immunological response to native
type II collagen in a dose - dependent manner . -
pubmed
The sensitivity of the
Na +/ H + exchanger to the oxidant ,
hydrogen peroxide (
H2O2 ) and the protection by the antioxidant
GSH suggests a possible role for the
Na+/H+ exchange mechanism in the formation of
cataracts . -
pubmed
The treatment of mesangial
IgA nephropathy with
cyclophosphamide ,
dipyridamole and
warfarin . -
pubmed
Cholesterol crystals and
IgE - containing immune complexes in
rheumatoid pericarditis . -
pubmed
The schistosomal specificity of
kidney lesions was assessed by detecting the schistosomal specific antigens (
CAA and
CCA ) and antibodies deposited in the renal glomeruli of these
patients . -
pubmed
Viruses and
cytokines : evidence for multiple roles in pancreatic beta cell destruction in
type 1 insulin - dependent diabetes mellitus . -
pubmed
To elucidate the possible role of viruses and
cytokines in the pathogenesis of
IDDM , we have examined the effect of
reovirus infection on
beta cell major histocompatibility complex (
MHC ) expression and the effect of
interferon - gamma (
IFN - gamma ) and
tumour necrosis factor - alpha (
TNF - alpha ) on beta cell function in vitro . -
pubmed
Infection of
RIN - m5F (
rat insulinoma ) cells with reovirus-1 or reovirus-3 was associated with a tenfold increase in
class 1 MHC protein and mRNA expression . -
pubmed
Reovirus infection did not induced the expression of
class 11 MHC by
RIN - m5F cells . -
pubmed
We studied the regulation of glycogen metabolism and
amino acid uptake in
human cultured
HEP - G2 hepatoma cells , which have distinct receptors for both
insulin and
IGF - I. -
pubmed
[ Immunohistochemical study of
carcinoembryonic antigen of the tissue and cell levels in
adenocarcinoma of the uterus ] . -
pubmed
UNLABELLED : Immunohistochemical staining was performed for
carcinoembryonic antigen (
CEA ) in tissues taken from 41 cases of cervical and 67 cases of endometrial
adenocarcinomas . -
pubmed
THE RESULTS : 1 ) The investigation at the tissue level indicated that
CEA staining was positive in 80 % of cases of cervical
adenocarcinoma . -
pubmed
3 ) Our observation revealed that
CEA was more prominent in the poorly differentiated type than in the well differentiated one , in both cervical and endometrial
adenocarcinoma . -
pubmed
Next potential long term effects of
insulin on the exocrine pancreas in vivo like regulation of the synthesis of certain digestive enzymes are described , followed by a discussion of long term
insulin effects in vitro employing
AR42J cells , a
rat pancreatic carcinoma acinar in origin . -
pubmed
[ Blood lipid and
beta - lipoprotein shifts in
acute digestive disorders in young
children ] . -
pubmed
Hepatocellular carcinoma in
primary biliary cirrhosis : detection by
alpha - fetoprotein estimation . -
pubmed
Serial estimations of
serum alpha - fetoprotein in 130 white
patients from the United Kingdom with
primary biliary cirrhosis who were followed for periods of 1 - 52 mo revealed 5 cases of
hepatocellular carcinoma ; all were subsequently confirmed histologically . -
pubmed
At the time
alpha - fetoprotein was first noted to be elevated , none had signs or symptoms of
tumor development . -
pubmed
A rise in ambient temperature augments
insulin absorption in
diabetic patients . -
pubmed
The absorption rate of 125I - Actrapid
insulin ( 6 U ) from a subcutaneous injection site was examined in six
insulin - dependent
diabetic patients at ambient temperatures of 20 degrees C and 35 degrees C. During a 4 - hr observation period , the
insulin disappearance rate at 35 degrees C was 50%-60 % greater than at 20 degrees C ( p less than 0.01 ) . -
pubmed
Despite the small dose of
insulin used , plasma
glucose levels tended to be 1 to 2 mmole / liter lower at 35 degrees C than at 20 degrees C. These findings indicate that a rise in ambient temperature augments
insulin absorption , in
insulin - treated
diabetic patients . -
pubmed
Twenty - seven pregnant
diabetic patients ( White 's class B through R ) received
insulin dosages twice daily as a combination of NPH and regular
insulin . -
pubmed
Histochemical methods demonstrated the recovery of the glycogen content , the activity of
succinate dehydrogenase and
alpha - glycerophosphate dehydrogenase as well as increased fluorescence of catecholaminergic nerves in short - term ischemized myocardium ( experimental
angina pectoris ) after stimulation of the carotid sinus nerve . -
pubmed
The scale of surgical
trauma was quantified by measuring
interleukin-6 in plasma and exudate from drainage tubes . -
pubmed
Though MAC positive sections showed reactivity for
S - protein , our observations support the possibility that
MAC , either acting directly or indirectly , may be implicated in
nerve damage , at least , in
lepromatous leprosy patients . -
pubmed
Adjuvant hepatic arterial
IL-2 and
MMC , 5 - FU after curative resection of
colorectal liver metastases . -
pubmed
BACKGROUND / AIMS : Based on our favorable results of
interleukin-2 - based immuno - chemotherapy in the treatment of unresectable
liver metastases from
colorectal cancer , we utilized this therapy for the prevention of liver recurrence after liver resection . -
pubmed
MATERIALS AND METHODS : Eighteen
patients with
colon cancer metastatic to the liver underwent successful hepatic resection and adjuvant immunochemotherapy that included hepatic arterial infusion of
interleukin-2 and
mitomycin C ,
5 - fluorouracil . -
pubmed
However , both treatments are effective in hampering Th2 cell development only if given at a time when
IL-4 has been produced for & lt;48 h. At this time after
infection , lymph node CD4 + T cells from BALB / c
mice no longer respond to
IL-12 . -
pubmed
This
IL-12 unresponsiveness is prevented in
mice treated with
anti - IL-4 Abs at the initiation of
infection . -
pubmed
Finally , the inhibition of Th2 development in BALB / c
mice treated with
anti - IL-4 Abs at the onset of
infection results from maintenance of
IL-12 responsiveness , since it requires
IL-12 . -
pubmed
Together , these results reveal a narrow window of time , between 16 h and & lt;48 h after
infection , during which
IL-4 produced rapidly in BALB / c
mice renders T cells unresponsive to
IL-12 , allowing their differentiation toward the Th2 phenotype . -
pubmed
A post - receptor defect of
adenylyl cyclase in severely failing myocardium from
children with
congenital heart disease . -
pubmed
The aim of this study was to determine whether a defect at the post - receptor level of
adenylyl cyclase may also contribute to the decreased effectiveness of
cAMP - increasing agents in severely failing
patients with
congenital heart disease . -
pubmed
beta - Adrenoceptor - stimulated
adenylyl cyclase activity was significantly decreased by 65 % in
patients with severe
heart failure in comparison to the group of
patients with no or mild
heart failure . -
pubmed
This post - receptor defect of
adenylyl cyclase was apparently due to a decrease in the activity of catalytic subunit of
adenylyl cyclase as
adenylyl cyclase stimulation by
forskolin in the presence of
Mn2 + which uncouples catalytic subunit from the
G proteins ,
G ( s ) and
G ( i ) , was also significantly diminished in the
patients with severe
heart failure . -
pubmed
In summary , the data indicate that a defect at the catalytic subunit of
adenylyl cyclase apparently contributes to the decreased effectiveness of
cAMP - increasing agents in severely failing
patients with
congenital heart disease . -
pubmed
pylori )
immunoglobulin G (
IgG ) antibody determinations ,
autoimmune reactivity ,
infections ,
allergies , and hyperreactivities were investigated . -
pubmed
A diagnosis of adult
celiac disease was made in two
patients and , additionally ,
IgA antigliadin antibodies were seen in four
patients . -
pubmed
The possible role of the proinflammatory
cytokines interleukin ( IL )- 1 ,
tumor necrosis factor - alpha ,
IL-6 , and
IL-8 as modulators of host resistance to
bacterial infections is discussed . -
pubmed
Interleukin-1 has been effective in various animal models of potentially lethal
bacterial infection , even during severe
granulocytopenia . -
pubmed
Moreover , in subacute and
chronic infections IL-1 interferes with microbial outgrowth via mechanisms that have only been partly elucidated . -
pubmed
RESULTS : Our results show that ( a ) SCE and HFC values in occupationally exposed nurses do not differ from controls , ( b ) patients with newly diagnosed
cancer or following chemotherapy show a number of SCE comparable to those of healthy donors , but a significantly different percentage of HFC , ( c ) cigarette smokers of all categories studied show higher frequencies of SCE and HFC as compared to nonsmokers , but the differences are not statistically significant , ( d ) the mutation frequency at the
TCR locus in oncology nurses is higher , but not significantly different from the frequency in the control group , and ( e ) the increase of mutation frequency is statistically significant and seems to be dose dependent in patients treated with high - dose chemotherapy . -
pubmed
CONCLUSIONS : Our data suggest that SCE frequency and HFC percentage are not reliable indicators of exposure to possible mutagenic /
carcinogenic effects of antineoplastic drugs ; on the contrary , our observations indicate that anticancer therapy induces somatic mutations at the
TCR locus and suggest an association between exposure to cytotoxic agents and the increase in somatic mutations . -
pubmed
Similarly ,
zebrafish one -
eyed pinhead (
oep ) mutants that have been rescued partially by mRNA injection display
heterotaxia , including randomization of heart looping and pancreas location . -
pubmed
BACKGROUND : Spurious increases in
serum troponins , especially
troponin T , have been reported in
patients with and without acute
myocardial syndromes . -
pubmed
METHODS : We studied 78 autopsied
patients without clinical
myocardial infarction (
MI ) and correlated histologic cardiac findings with antemortem
serum creatine kinase (
CK ) , its
MB isoenzyme (
CK - MB ) ,
cardiac troponin I (
cTnI ) , and
cardiac troponin T (
cTnT ) . -
pubmed
Compared with the no - pathology group , only the
MI group was significantly different for
cTnI , and the
MI and other pathology groups were significantly different for
cTnT. -
pubmed
For
patients with
MI , 22 % , 19 % , 48 % , and 65 % had increased
CK ,
CK - MB ,
cTnI , and
cTnT , respectively ; for
CHF and other
cardiac pathologies combined , the percentages were 28 % , 17 % , 22 % , and 50 % . -
pubmed
For
patients with increased
cTnI , 72 % and 28 % had
MI and other
myocardial pathologies , respectively ;
patients with increased cTnT had 64 % and 36 % , respectively . -
pubmed
The second - generation cTnT assay appears to be a more sensitive indicator of
MI and other
myocardial pathologies than the
cTnI assay used in this study . -
pubmed
The causative biochemical defect has been identified as a
deficiency of the enzyme fatty aldehyde dehydrogenase , a component of
fatty alcohol :
NAD + oxidoreductase . -
pubmed
Interferon - gamma receptor signaling is dispensable in the development of
autoimmune type 1 diabetes in NOD
mice . -
pubmed
There have been two previous conflicting reports that the development of
T - cell - mediated autoimmune diabetes (
type 1 diabetes ) was respectively unaffected or inhibited in NOD
mice genetically deficient in the
T - helper ( Th ) 1 cytokine interferon ( IFN )- gamma or the
alpha - chain subunit of its receptor . -
pubmed
However , despite being unable to respond to the primary Thl
cytokine IFN - gamma and having T - cells that produce greatly enhanced levels of
IL-4 , NOD.IFNgammaRBnull
mice remained highly susceptible to
type 1 diabetes . -
pubmed
Furthermore , our results indicate that the pathogenicity of diabetogenic T - cells in
NOD mice is not dampened by an inability to respond to
IFN - gamma and a concurrent shift to greatly enhanced Th2
cytokine production . -
pubmed
This finding calls into question whether clinical protocols designed to shift beta - cell autoreactive T - cells from a Thl to Th2
cytokine production profile will truly be safe and efficacious in blocking the development of
type 1 diabetes in
humans . -
pubmed
Somatostatin receptor type 2 gene expression in
neuroblastoma , measured by competitive RT - PCR , is related to
patient survival and to
somatostatin receptor imaging by
indium - 111 - pentetreotide . -
pubmed
BACKGROUND : We previously reported that
human neuroblastoma cell lines and primary
neuroblastoma tumors expressed a variable amount of mRNA for
type 2 somatostatin ( sst2 ) receptor gene . -
pubmed
We found that the lowest level of
sst2 mRNA was detected in advanced stages of
neuroblastomas ( stage IV ) when compared with the other stages ( P< ; 0.005 ) . -
pubmed
Finally we verified that the ex vivo
sst2 gene expression in
tumor samples was positively related ( P & lt ; 0.01 ) to the in vivo semiquantitative determination of
sst2 protein , assessed by
111In - pentetreotide imaging . -
pubmed
CONCLUSIONS : Our data indicate that the measurement of
sst2 mRNA measurement could represent a relevant tool in the prediction of
neuroblastoma outcome , independently from
MYCN amplification . -
pubmed
Furthermore , work - related symptoms were more prevalent among the exposed workers than among the referents ( eyes 23 % versus 14 % , nose 28 % versus 16 % ,
nose bleeding 8 % versus 0 % , lower airways 10 % versus 4 % ) , and they were related to the exposure ( adjusted prevalence odds ratios ( POR ) in the highest group 7.7 , 3.6 and 17 , respectively ) and the
IgE levels (
POR 4.9 , 3.1 and 5.6 , respectively ) . -
pubmed
CONCLUSIONS : In spite of the very low
OAA levels in the air and metabolites in the urine , there were high and exposure - related risks of specific
IgE and
IgG sensitization and of work - related symptoms for the eyes , nose ( especially
bleeding ) , and lower airways . -
pubmed
EFFECT OF
IRON DEFICIENCY ON THE RELATIVE RATES OF SYNTHESIS OF
HAEMOGLOBINS A AND E AS STUDIED IN A
HEAMOGLOBIN E HETEROZYGOTE . -
pubmed
The relationship between expression of
p53 /
bcl-2 and clinicopathological criteria in
cervix squamous cell carcinomas . -
pubmed
Low levels of
apolipoprotein A1 (
ApoA1 ) and
cholesterol in the serum and undetectable levels of
high density lipoprotein (
HDL ) and
low density lipoprotein (
LDL )
cholesterol in the blood confirmed the diagnosis of
TD . -
pubmed
Using Medicare claims , we identified patients with
diabetes , linked them to practices , and assessed the use of
glycohemoglobin ( GHb ) tests , eye examinations , and lipid profiles . -
pubmed
The role of regulatory T cells in antigen - induced
arthritis : aggravation of
arthritis after depletion and amelioration after transfer of CD4+
CD25 + T cells . -
pubmed
It is now generally accepted that
CD4+
CD25 + Treg cells play a major role in the prevention of
autoimmunity and pathological immune responses . -
pubmed
Depletion of
CD25 - expressing cells in immunized animals before
arthritis induction led to increased cellular and humoral immune responses to the inducing antigen ( methylated
bovine serum albumin ; mBSA ) and autoantigens , and to an exacerbation of
arthritis , as indicated by clinical ( knee joint swelling ) and histological scores . -
pubmed
These data imply a significant role for
CD4+
CD25 + Treg cells in the control of
chronic arthritis . -
pubmed
These results indicate that the catalytic domain of
AtlA is located at the C terminus , suggesting that further characterization of this domain may provide a means to control
cariogenic dental plaque formation . -
pubmed
Transplants from partially
human leukocyte antigens (
HLA)-incompatible relatives are associated with an increased risk of graft rejection ,
graft - versus - host disease (
GVHD ) , and lower survival , which are correlated with the degree of disparity . -
pubmed
Promoter - hypermethylation is causing functional relevant downregulation of
methylthioadenosine phosphorylase (
MTAP ) expression in
hepatocellular carcinoma . -
pubmed
Here , frequently homozygous deletions occur in several kinds of
cancer associated with the loss of
tumour suppressor genes as
p16 and
p15 . -
pubmed
The aim of this study was to analyse
MTAP expression in
hepatocellular carcinoma (
HCC ) and to get an insight into the regulation and functional role of
MTAP in hepatocancerogenesis . -
pubmed
Compared with primary
human hepatocytes
MTAP expression was markedly downregulated in three different
HCC cell lines as determined by real - time PCR and western blotting . -
pubmed
Reduced
MTAP - expression was confirmed in vivo in
HCC compared with
non - cancerous liver tissue on both mRNA and protein levels . -
pubmed
To study the functional relevance of the downregulated
MTAP expression in
HCC ,
MTAP expression was re - induced in
HCC cell lines by stable transfection . -
pubmed
In conclusion , our results suggest a functional role of
MTAP inactivation in
HCC development and invasiveness . -
pubmed
Inflammation and injury might be caused by oxidant - mediated expression of
inflammatory cytokine interleukin-8 (
IL-8 ) and inflammatory enzymes such as
cyclooxtgenase-2 (
COX-2 ) and
inducible nitric oxide synthase (
iNOS ) , which were mediated by oxidant - sensitive transcription factors such as
nuclear factor - kappaB (
NF - kappaB ) and
activator protein-1 (
AP-1 ) , possibly with
mitogen activated protein kinase (
MAPK ) activation . -
pubmed
Polyamine oxidase and
acrolein as novel biochemical markers for diagnosis of
cerebral stroke . -
pubmed
BACKGROUND AND PURPOSE : We found previously that plasma levels of
acrolein ( CH2 =
CHCHO ) and
spermine oxidase (
SMO ) were well correlated with the degree of severity of
chronic renal failure . -
pubmed
The aim of this study was to test whether the levels of these 2 markers and of
acetylpolyamine oxidase (
AcPAO ) were increased in the plasma of
stroke patients . -
pubmed
METHODS : The activity of
AcPAO and
SMO and the level of protein - conjugated
acrolein in plasma of the
stroke patients and normal
subjects were measured by high - performance liquid chromatography and ELISA , respectively . -
pubmed
The size of
stroke was nearly parallel with the multiplied value of
acrolein and total
polyamine oxidase (
AcPAO plus SMO ) . -
pubmed
Furthermore ,
stroke was confirmed by MRI in a number of mildly symptomatic
patients ( 11 cases ) who had increased levels of total
polyamine oxidase and
acrolein . -
pubmed
Among apparently normal
subjects ( 8 cases ) who had high values of acroleinxtotal
polyamine oxidase ,
stroke was found in 4 cases by MRI . -
pubmed
The use of chemotherapy with anti -
CD20 monoclonal antibody led to complete clinical remission of
lymphoma . -
pubmed
Complete lack of expression of
WASP carries a greater risk for severe
infections ,
bleeding , or
malignancy development in
WAS . -
pubmed
However , rare patients with residual expression of mutated
WASP , like this patient , still may develop
lymphomas . -
pubmed
The results suggest that
sigma1 receptors play an important role against
retinal damage , even though
sigma2 receptor involvement can not be excluded . -
pubmed
A
protein farnesyltransferase inhibitor ameliorates disease in a
mouse model of
progeria . -
pubmed
Several
progeroid disorders are caused by mutations that lead to the accumulation of a lipid - modified ( farnesylated ) form of
prelamin A , a protein that contributes to the structural scaffolding for the cell nucleus . -
pubmed
coli O157 antiserum , vero cell
cytotoxicity assay to detect verocytotoxin (
VT ) and
heat labile toxin (
LT ) production , the polymerase chain reaction ( PCR ) to detect VT genes , and the dry spot test to screen for
E. - pubmed
Cytotoxic T lymphocyte - associated antigen-4 gene polymorphisms confer susceptibility to
atopic asthma in Korean children . -
pubmed
The gene encoding
CTLA-4 is a candidate gene for conferring susceptibility to
allergic disease . -
pubmed
The purpose of this study was to evaluate the potential effects of
CTLA-4 gene polymorphisms in Korean children on
asthma . -
pubmed
As a result , allele and genotype frequencies of the
CTLA-4 exon 1 + 49 G & gt ; A polymorphism were different to some extent between the
atopic asthma children and the controls with P<0.05 , which did not reach statistical significance after the correction of multiple comparisons . -
pubmed
Polymorphisms in the
CTLA-4 gene likely confer susceptibility to
atopic asthma in Korean children . -
pubmed
In multivariable analyses and adjusting for established risk factors and additionally for glomerular filtration rate and for
hemoglobin ,
serum albumin ,
proteinuria , and
C - reactive protein levels , a higher level of serum
phosphorus was associated with an increased
CVD risk in a continuous fashion ( adjusted hazard ratio per increment of milligrams per deciliter , 1.31 ; 95 % confidence interval , 1.05 - 1.63 ; P=.02 ; P value for trend across quartiles = .004 ) . -
pubmed
PURPOSE : Increased
epidermal growth factor receptor (
EGFR ) expression may promote
breast cancer resistance to endocrine therapy . -
pubmed
PATIENTS AND METHODS : Postmenopausal
women with stage I to IIIB
hormone receptor - positive early
breast cancer received
anastrozole 1 mg daily for 16 weeks and were randomly assigned at a ratio of 2:5:5 to receive , in addition ,
gefitinib 250 mg / d orally for 16 weeks : placebo 1 tablet / d orally for 2 weeks and then
gefitinib for 14 weeks or placebo for 16 weeks . -
pubmed
Neprilysin gene expression requires binding of the
amyloid precursor protein intracellular domain to its promoter : implications for
Alzheimer disease . -
pubmed
Amyloid beta - peptide (
Abeta ) accumulation leads to neurodegeneration and
Alzheimer disease ; however , amyloid metabolism is a dynamic process and enzymic mechanisms exist for
Abeta removal . -
pubmed
TLR9 activation is important for the maintenance of mycobacteria - elicited pulmonary granulomatous responses , hallmarks of protective immune responses following
mycobacterial infection . -
pubmed
Passively immunizing WT
mice with neutralizing antibodies specific for
dll4 during
granuloma formation resulted in larger granulomas and lower levels of Th17 - related
cytokines . -
pubmed
Furthermore ,
TLR9 seems to be required for optimal
dll4 expression and the regulation of Mycobacterium antigen - elicited
granuloma formation in
mice . -
pubmed
Our results showed that in vitro digestion of cooked eggs could generate a number of potent
ACE inhibitory peptides which may have implications for
cardiovascular disease prevention , including
hypertension . -
pubmed
RESULTS : Significant associations were found between
caries , age and specific individual submandibular / sublingual salivary proteins (
lactoferrin ,
albumin ,
lysozyme ,
mucin and
cystatin ) and specific inorganic constituents ( K+ ,
Ca2 + ,
Na+ and
Cl- ) . -
pubmed
Currently ,
vasopressin and
terlipressin are most commonly used to stimulate
V1R in vasodilatory shock and
cardiac arrest , while
desmopressin , a synthetic analogue of
vasopressin , acts on
V2R ; but new molecules are becoming available in the treatment of inappropriate antidiuretic hormone (
ADH ) secretion . -
pubmed
Immunohistochemical staining of malignant Brenner
tumor often demonstrates positivity for
uroplakin III ,
thrombomodulin and
cytokeratin 7 and negativity to
cytokeratin 20 . -
pubmed
Risk - reducing salpingo - oophorectomy ( RRSO ) is the most definitive surgical intervention for
ovarian cancer risk reduction among
BRCA1 / 2 mutation carriers . -
pubmed
Detection of
EGFR mutations with mutation - specific antibodies in stage IV
non - small - cell lung cancer . -
pubmed
BACKGROUND : Immunohistochemistry ( IHC ) with mutation - specific antibodies may be an ancillary method of detecting
EGFR mutations in
lung cancer patients . -
pubmed
METHODS :
EGFR mutation status was analyzed by DNA assays , and compared with IHC results in five
non - small - cell lung cancer (
NSCLC ) cell lines and
tumor samples from 78 stage IV
NSCLC patients . -
pubmed
RESULTS : IHC correctly identified del 19 in the
H1650 and
PC9 cell lines , L858R in
H1975 , and wild - type
EGFR in
H460 and
A549 , as well as wild - type
EGFR in
tumor samples from 22 patients . -
pubmed
CONCLUSIONS : IHC with mutation - specific mAbs against
EGFR is a promising method for detecting
EGFR mutations in
NSCLC patients . -
pubmed
However these mAbs should be validated with additional studies to clarify their possible role in routine clinical practice for screening
EGFR mutations in
NSCLC patients . -
pubmed
Multiple observational studies have consistently shown that increased body mass index as well as
insulin resistance and increased fasting
insulin levels is associated with
chronic kidney disease , even after adjustment for related disorders . -
pubmed
These compounds may be useful for behavioral pharmacology studies on the role of
D ( 2 )- like dopamine receptors in neuropsychiatric and
neurological disorders . -
pubmed
OBJECTIVES :
Beryllium sensitisation ( BeS ) and
chronic beryllium disease (
CBD ) are caused by exposure to
beryllium with susceptibility affected by at least one well - studied genetic host factor , a
glutamic acid residue at position 69 ( E69 ) of the
HLA - DPbeta chain (
DPbetaE69 ) . -
pubmed
Involvement of
p53 R72P polymorphism in the association of
MDM2 - SNP309 with
breast cancer . -
pubmed
The allelic variant
MDM2 - SNP309 ( T>G ) has been suggested to influence
cancer development , but the clinical correlation between the risk allele and
breast cancer remains controversial . -
pubmed
In this study , we investigated whether
MDM2 - SNP309 is associated with
p53 R72P genetic polymorphism for the risk of
breast cancer development in Asian Taiwanese , which has not been well - studied in this regard . -
pubmed
Two hundred and fifty - five patients and 324
cancer - free controls were included , and we found that the
MDM2 - SNP309 TG and GG genotypes displayed marginally increased risks of
breast cancer ( GG vs. TT : OR = 1.7 , 95 % CI = 0.93 to 3.09 ; TG + TT vs. TT : OR = 1.57 , 95 % CI = 0.98 to 2.56 ) . -
pubmed
The
breast cancer risk associated with
MDM2 - SNP309 was enhanced after stratification for the homozygous GG genotype at
p53 codon 72 representing the Arg form of this genotype ( GG vs. TT : OR = 3.7 , 95 % CI = 1.144 to 12.02 ; TG + GG vs. TT : OR = 2.7 , 95 % CI = 1.027 to 6.895 ) . -
pubmed
Moreover , the G - allele of
MDM2 - SNP309 exhibited a stronger capacity than the T - allele to drive the full - length P2 promoter of the
MDM2 gene in several human cell lines , suggesting that the association between
MDM2 -
SNP309 and
breast cancer is likely multifactorial rather than due to inconsistent gene expression in different
cancer sources . -
pubmed
OBJECTIVE : To investigate the influence of Bushenguchiwan on expression of
matrix metalloproteinase-13 (
MMP-13 ) in periodontium of
rats with experimental
periodontitis . -
pubmed
RESULTS :
MMP-13 was intensely positive in gingival epithelial cells and periodontal fibroblasts in
periodontitis models and negative in normal
rat periodontal tissues . -
pubmed
Antibodies to
lytic infection proteins in lymphocryptovirus - infected rhesus macaques : a model for humoral immune responses to
epstein - barr virus infection . -
pubmed
Serum antibodies to
rhBARF1 were frequently detected in healthy
rhLCV - infected macaques , but in
humans ,
anti - BARF1 antibodies have been reported primarily in patients with
EBV - positive
nasopharyngeal carcinoma (
NPC ) . -
pubmed
The macaque data accurately predicted that serum antibodies against
BARF1 are a normal response to
EBV infection when
human serum samples are analyzed . -
pubmed
Genetic alterations of
ALK are associated with a number of
cancers , including
anaplastic large cell lymphoma (
ALCL ) and a subset of
non - small cell lung cancer (
NSCLC ) . -
pubmed
Along the same way shown by
imatinib in
chronic myeloid leukemia , compounds that selectively target
ALK are bringing a revolution in the treatment of
ALK - positive tumors . -
pubmed
Familial Adenomatous Polyposis (
FAP ) due to loss of the
APC gene and
Lynch syndrome or
Hereditary Non - Polyposis Colon Cancer (
HNPCC ) due to breakdown in MisMatch Repair are the principal syndromes of broader interest and both have been the subject of chemoprevention trials . -
pubmed
There has been a longstanding interest in non - steroidal anti inflammatories in
FAP where trials have shown regression of
polyps with the " pro drug"
sulindac and the selective
COX2 inhibitors though impact on long - term
cancer risk is not confirmed . -
pubmed
We found 3 genes
SORCS1 ,
AMPD1 , and
PPARalpha to be associated with the development of both
IGT and IFG , while 5 genes
AMPD2 ,
PRKAA2 ,
C5 ,
TCF7L2 , and
ITR with the IGT mechanism only and 6 genes
CAPN10 ,
IL4 ,
NOS3 ,
CD14 ,
GCG , and
SORT1 with the IFG mechanism only . -
pubmed
Mice lacking
Klotho or
fibroblast growth factor 23 (
FGF23 ) exhibit a
premature aging syndrome associated with abnormal mineral metabolism characterized by
hyperphosphatemia ,
hypercalcemia , and
hypervitaminosis D. -
pubmed
Hyperphsophatemia , decreased
Klotho expression , and aging - like symptoms are often manifested in
patients with
chronic kidney disease (
CKD ) . -
pubmed
Cytokines , which usually serve as signals between neighboring cells , are involved in essentially every important biological process , including cell proliferation ,
inflammation , immunity , migration ,
fibrosis , tissue repair , and angiogenesis . -
pubmed
Cytokines and
chemokines are multifunctional mediators that can direct the recruitment of leukocytes to sites of
inflammation , promote the process , enhance immune responses , and promote stem cell survival , development , and homeostasis . -
pubmed
Recent findings concerning the statistical laws of behavioral organization shared between healthy
humans and wild - type
mice ( WT ) and their alterations in
human depression patients and circadian clock gene (
Period 2 ;
Per2 ) mutant
mice indicate that clock genes play functional roles in intermittent , ultradian locomotor dynamics . -
pubmed
Furthermore , based on a stochastic priority queuing model , we explained the power - law nature of resting period distributions , as well as its alterations shared with
human depressive patients and
Per2 mutant
mice . -
pubmed
Antitumor activity of the selective pan -
RAF inhibitor
TAK-632 in
BRAF inhibitor - resistant
melanoma . -
pubmed
The
mitogen - activated protein kinase (
MAPK ) pathway is particularly important for the survival and proliferation of
melanoma cells . -
pubmed
Somatic mutations in
BRAF and
NRAS are frequently observed in
melanoma . -
pubmed
Recently , the
BRAF inhibitors
vemurafenib and
dabrafenib have emerged as promising agents for the treatment of
melanoma patients with
BRAF - activating mutations . -
pubmed
However , as
BRAF inhibitors induce
RAF paradoxical activation via
RAF dimerization in
BRAF wild - type cells , rapid emergence of acquired resistance and secondary
skin tumors as well as presence of few effective treatment options for
melanoma bearing wild - type
BRAF ( including
NRAS - mutant
melanoma ) are clinical concerns . -
pubmed
As a result ,
TAK-632 demonstrates potent antiproliferative effects both on
NRAS - mutated melanoma cells and
BRAF - mutated
melanoma cells with acquired resistance to
BRAF inhibitors through
NRAS mutation or
BRAF truncation . -
pubmed
Our findings characterize the unique features of
TAK-632 as a pan -
RAF inhibitor and provide rationale for its further investigation in
NRAS - mutated
melanoma and a subset of
BRAF - mutated
melanomas refractory to
BRAF inhibitors . -
pubmed
There is evidence that skeletal muscle
adiponectin resistance may develop in
obesity and play a role in the pathogenesis of
diabetes . -
pubmed
Huntington ' s disease (
HD ) is the most common
polyglutamine neurodegenerative disorder in
humans , and is caused by a mutation of an unstable expansion of CAG repeats within the coding region of the
HD gene , which expresses the protein
huntingtin . -
pubmed
The
androgen receptor (
AR ) is a
ligand - activated transcription factor that is essential for
prostate cancer development . -
pubmed
MicroRNA-181a promotes
tumor growth and liver metastasis in
colorectal cancer by targeting the
tumor suppressor
WIF-1 . -
pubmed
In this article , we demonstrate that increasing plasma MG to levels observed in
diabetic mice either using an exogenous source ( 1 % in drinking water ) or generated following inhibition , its primary clearance enzyme ,
glyoxalase-1 ( with 50 mg / kg IP
bromobenzyl - glutathione cyclopentyl diester every second day ) , was able to increase vascular adhesion and augment atherogenesis in euglycemic
apolipoprotein E knockout mice to a similar magnitude as that observed in
hyperglycemic mice with
diabetes . -
pubmed
The effects of MG appear partly mediated by activation of the
receptor for advanced glycation end products (
RAGE ) , as deletion of
RAGE was able to reduce
inflammation and atherogenesis associated with MG exposure . -
pubmed
However ,
RAGE deletion did not completely prevent
inflammation or
vascular damage , possibly because the induction of mitochondrial oxidative stress by
dicarbonyls also contributes to
inflammation and atherogenesis . -
pubmed
Such data would suggest that a synergistic combination of
RAGE antagonism and antioxidants may offer the greatest utility for the prevention and management of
diabetic vascular complications . -
pubmed
Accelerated , spleen - based titration of variant
Creutzfeldt - Jakob disease infectivity in transgenic
mice expressing
human prion protein with sensitivity comparable to that of survival time bioassay . -
pubmed
To address this limitation , we tested the potential of a transgenic
mouse line overexpressing
human prion protein (
PrP ) , which was previously reported to propagate
vCJD prions . -
pubmed
Endpoint titration of
vCJD infectivity in different tissues was evaluated by two different methods : ( i ) the " classical " bioassay , based on the appearance of clinical symptoms and the detection of pathological
prion protein in tissues of the inoculated
mouse , and ( ii ) a shortened bioassay based on the detection of the protein in the
mouse spleen at defined time points . -
pubmed
Also ,
teratomas were not seen in
mice with
severe combined immunodeficiency syndrome (
SCID ) that received a transplantation of hfMSCs with
hTERT activity . -
pubmed
Inflammatory bowel disease was associated with significantly higher levels of
fibrinogen ,
PT ,
factor V ,
factor VIII ,
plasminogen and thrombocyte . -
pubmed
Protein S ,
fibrinogen ,
plasminogen and thrombocyte levels were associated with disease activity , depending on the type of the disease (
Crohn ' s disease or
ulcerative colitis ) . -
pubmed
Extrasynaptic
glutamate release through
cystine / glutamate antiporter contributes to
ischemic damage . -
pubmed
During
brain ischemia , an excessive release of
glutamate triggers neuronal death through the overactivation of
NMDA receptors ( NMDARs ) ; however , the underlying pathways that alter
glutamate homeostasis and whether synaptic or extrasynaptic sites are responsible for excess
glutamate remain controversial . -
pubmed
In contrast , pharmacological inhibition of the
cystine / glutamate antiporter dramatically attenuated
ischemia - gated currents and cell death after OGD . -
pubmed
Hedgehog pathway mutations in
T - cell acute lymphoblastic leukemia . -
pubmed
CE1 and CE2 HF exhibited comparable spotting patterns , but CE2
HF harbored greater amounts of
EgAgB and
EgAg5 complexes . -
pubmed
Patient sera of
alveolar echinococcosis ( AE ) cross - reacted with diverse
EgAgB isoforms ( 36 % ) . -
pubmed
EgAg5 and
cathepsin B also demonstrated cross - reactions with sera from
neurocysticercosis and
sparganosis . -
pubmed
Reslizumab , a neutralizing anti -
IL-5 monoclonal antibody , is a promising adjunctive treatment for severe
eosinophilic asthma . -
pubmed
In addition , our in vitro pilot study with
3T3 - L1 cells showed that
vitexin , the functional chemical in
MBT , inhibited
inflammation - induced lipogenesis with significantly lower amounts of
IL-6 and
MCP-1 after 14 days of
vitexin treatment . -
pubmed
After two serial passages in vivo , SHIV ( SHIV-89.6P ) induces
CD4 lymphopenia and an
AIDS - like disease with wasting and
opportunistic infections . -
pubmed
We found especially high immune activation , low
IFN - alpha expression , and distinctive
cytokine expression profiles in the infected and dead ( ID ) group of
monkeys , while there was only few change in the
CD4(+ ) T counts and distribution of T cell subsets in the
ID group monkeys . -
pubmed
These results suggest that
SHIV89.6 infections have pathogenic potential in
CRMs and that high immune activation and abnormal expression of
cytokines contribute to death of
SHIV89.6 - infected
CRMs . -
pubmed
Identification of
IL13 C1923 T as a Single Nucleotide Polymorphism for
Asthma in Children from Mauritius . -
pubmed
However , the frequency of
IL13 C1923 T TT in the
asthma group was significantly higher than in the control group ( odds ratio=2.119 , p=0.033 ) suggesting that carriers of
IL13 C1923 T TT in the Mauritian population may have a more significant risk of developing
asthma . -
pubmed
IL13 C1923 T TT has been detected to be the susceptible genotype and may have a significant effect on the pathogenesis of childhood
asthma in the Mauritian population . -
pubmed
Histological findings showed that
rutin administration significantly reduced
renal interstitial injury and suppressed interstitial
collagen deposits in UUO
rats . -
pubmed
Taken together , the renoprotective effects of
rutin in
obstructive nephropathy were likely due to anti - inflammatory effects and inhibition of
TGF - beta1 /
Smad3 signaling . -
pubmed
BRAF(V600E ) Mutation is Associated with Decreased Disease - Free Survival in
Papillary Thyroid Cancer . -
pubmed
BACKGROUND : The
BRAF ( V600E ) mutation is a recognised molecular marker in
papillary thyroid cancer (
PTC ) , reported incidence from 30 to 80 % . -
pubmed
Previous studies have reported conflicting data regarding the impact of
BRAF(V600E ) on clinicopathological features of
PTC . -
pubmed
The study aims to determine whether
BRAF(V600E ) is useful as a prognostic biomarker in
PTC . -
pubmed
RESULTS : 496 patients with
PTC were included , and 309 ( 62 % ) were
BRAF(V600E ) positive . -
pubmed
Tumour size was similar for
BRAF(V600E)-positive and -negative
tumours ( 21.3 vs. 23.2 mm , p = 0.23 ) . -
pubmed
BRAF(V600E)-positive
PTCs had a higher rate of
disease recurrence ( 12.9 vs. 5.6 % , p = 0.004 ) , lymph node metastasis ( 44 vs. 29.4 % , p = 0.004 ) and extra - thyroidal extension ( 44 vs. 22 % , p & lt ; 0.001 ) . -
pubmed
Five - year disease - free survival was 89.6 % for
BRAF(V600E ) positive and 96.3 % for negative
tumours , p & lt ; 0.001 . -
pubmed
CONCLUSION :
BRAF(V600E ) in
PTC predicts an increased risk of lymph node metastasis , extra - thyroidal extension and reduced
disease - free survival . -
pubmed
In
EoE cases refractory to conventional treatments , newer therapies targeting inflammatory mediators and
cytokines are on the horizon . -
pubmed
A role for pulmonary endothelial cells in the orchestration of
cytokine production and leukocyte recruitment during
influenza virus infection , leading to severe
lung damage , has been recently identified . -
pubmed
IFITM3 knockdown by small interfering RNA ( siRNA ) could partially rescue
H1N1 virus infection in
HULEC , suggesting
IFITM3 proteins were involved in blocking
human influenza virus infection in endothelial cells . -
pubmed
We show that human
influenza virus infection is blocked during the early stages of virus entry , which is likely due to the relatively high expression of the host antiviral factors
IFITMs (
interferon - induced transmembrane proteins ) located in membrane - bound compartments inside cells . -
pubmed
Expression of
Carbonic Anhydrase I in Motor Neurons and Alterations in
ALS . -
pubmed
Helicobacter pylori vacA s1m1 genotype but not
cagA or
babA2 increase the risk of
ulcer and
gastric cancer in patients from Southern Mexico . -
pubmed
The objectives were to determine the frequency of
infection and distribution of the
vacA ,
cagA and
babA2 genotypes of
H. - pubmed
babA2 was associated with
gastric cancer , and
cagA was not associated with the diagnosis . -
pubmed
pylori and the s1m1 genotype were associated with
gastric cancer and the
s1m1 /
cagA+/
babA2 + strains predominated in
tumor and adjacent tissue . -
pubmed
Correction :
Oleuropein down - regulated
IL-1beta - induced
inflammation and oxidative stress in
human synovial fibroblast cell line
SW982 . -
pubmed
Correction for '
Oleuropein down - regulated
IL-1beta - induced
inflammation and oxidative stress in
human synovial fibroblast cell line
SW982 ' by Maria Luisa Castejon , et al . -
pubmed
In this study , we found that
HSP90 was cleaved to a 55kDa protein after treatment with proteasome inhibitors including
MG132 in
leukemia cells but was not cleaved in other tissue - derived cells . -
pubmed
The full functional characterization of bone and striated muscle microcirculatory parameters in
non - obese diabetic - severe combined immunodeficiency / y - chain ; NOD -
Prkds IL2rg ( NSG )
mice has not yet been reported . -
pubmed
Our results showed that high salt intake resulted in higher mean arterial pressure ,
cardiac hypertrophy as well as increased plasma level of
norepinephrine and
interleukin ( IL )- 1beta ,
IL-6 compared with NS
rats . -
pubmed
FoxR2 promotes
glioma proliferation by suppression of the
p27 pathway . -
pubmed
FoxR2 plays an important role in the development of many
human tumors . -
pubmed
However , the effects of
FoxR2 on tumorigenicity of
human glioma remain unclear . -
pubmed
In this study , we investigated the roles of
FoxR2 in cell proliferation and invasion of
glioma . -
pubmed
We found that overexpression of
FoxR2 promoted the proliferation , migration and invasion of
glioma cells . -
pubmed
Taken together , these results indicate that upregulation of
FoxR2 may confer enhanced tumorigenicity in
glioma cells . -
pubmed
We evaluated the model of
psoriasis and
EGFR siRNA treatment ( as spherical nucleic acid nanoparticles ) , phenotypically ( signs of
erythema , scaling ,
inflammation and thickening ) , microscopic evaluation of cell proliferation and immunohistochemically evaluation of
CD3 ,
CD4 , and
CD8 markers . -
pubmed
Transforming growth factor - beta signaling in
systemic sclerosis . -
pubmed
Transforming growth factor beta (
TGF - beta ) has been identified as a regulator of pathological fibrogenesis in
SSc . -
pubmed
Understanding the essential role
TGF - beta pathways play in the pathology of
systemic sclerosis could provide a potential outlet for treatment and a better understanding of this severe disease . -
pubmed
CD44 knockdown in
cancer diminished
glutathione , but not HT in
tumours . -
pubmed
Mechanisms whereby
tumours sustained HT under
CD44 - knockdown conditions include upregulation of
PHGDH ,
PSAT1 and
PSPH that drove glycolysis - dependent activation of
serine /
glycine - cleavage systems to provide one -
methyl group for HT synthesis . -
pubmed
Of interest are three genes ,
eEF1A1 ,
CASK , and
PSMD6 that are linked to
PARK2 activity in the cell and thereby form attractive candidate genes for understanding
PD . -
pubmed
Interferons in
Traumatic Brain and Spinal Cord Injury : Current Evidence for Translational Application . -
pubmed
This review article provides a general perspective of the experimental and clinical work surrounding the role of
type - I , type - II , and type - III interferons (
IFNs ) in the pathophysiology of
brain and spinal cord injury . -
pubmed
Since
IFNs are themselves well - known therapeutic targets ( as well as pharmacological agents ) , and anti -
IFNs monoclonal antibodies are being tested in clinical trials , it is timely to review the basis for the repurposing of these agents for the treatment of
brain and spinal cord traumatic injury . -
pubmed
Experimental evidence suggests that
IFN - alpha may play a detrimental role in
brain trauma , enhancing the pro - inflammatory response while keeping in check astrocyte proliferation ; converging evidence from genetic models and neutralization by monoclonal antibodies suggests that limiting
IFN - alpha actions in
acute trauma may be a suitable therapeutic strategy . -
pubmed
Effects of
IFN - beta administration in spinal cord and
brain trauma have been reported but remain unclear or limited in effect . -
pubmed
Despite the involvement in the inflammatory response , the role of
IFN - gamma remains controversial : although
IFN - gamma appears to improve the outcome of
traumatic spinal cord injury , genetic models have produced either beneficial or detrimental results . -
pubmed
To date ,
IFN - alpha appears to most promising target for drug repurposing , and monoclonal antibodies anti
IFN - alpha or its receptor may find appropriate use in the treatment of
acute brain or spinal cord injury . -
pubmed
There has been an explosion in our knowledge of
autoimmune encephalitis associated with antibodies to neuronal cell surface antigens , and two of the most common forms ,
anti - NMDA receptor encephalitis and
anti - LGI1 encephalitis , are typically associated with distinctive clinical features . -
pubmed
Type - I interferons (
IFN - I ) are used as common antiviral drugs for a range of
viral diseases in clinic . -
pubmed
Interestingly ,
viral infection upregulates
USP7 and therefore facilitates viral immune evasion . -
pubmed
Erythropoiesis defect observed in
STAT3 GOF patients with severe
anaemia . -
pubmed
STAT3 mediates
inflammation and modulates immunity . -
pubmed
Commentary of the impact of
obesity and puberty on
insulin sensitivity . -
pubmed
Sam68 promotes aerobic glycolysis in
colorectal cancer by regulating
PKM2 alternative splicing . -
pubmed
Background :
Sam68 , an RNA - binding protein , exerts oncogenic functions in several types of
cancer . -
pubmed
However , the specific functions and mechanisms of
Sam68 in
colorectal cancer (
CRC ) had not been previously clarified . -
pubmed
Pyruvate kinase muscle ( PKM ) 2 is the key rate - limiting enzyme in glycolysis , and
PKM2 maintains the glycolysis - dominant energy metabolism in most
cancer cells . -
pubmed
Results : Gain - of - function and loss - of - function studies showed that ectopic expression of
Sam68 promoted glycolysis and cell proliferation in
CRC cells , whereas
Sam68 knockdown inhibited glycolysis and cell proliferation . -
pubmed
Sam68 significantly promoted cell proliferation and caused a decrease of
PKM1 /
PKM2 ratio , resulting in the metabolism of
glucose switched from oxidative phosphorylation to glycolysis in
CRC cells . -
pubmed
Conclusions : These findings suggested that
Sam68 affected cell growth and glycolysis pathway by regulating the alternative splicing and expression of
PKM2 in
CRC . -
pubmed
Childhood trauma ,
psychiatric disorders , and criminality in women : Associations with serum levels of
brain - derived neurotrophic factor . -
pubmed
The aim of this study was to determine whether five childhood
trauma subtypes -
physical abuse ,
sexual abuse ,
emotional abuse ,
physical neglect , and
emotional neglect - are associated with adult
psychiatric disorders ,
BDNF levels , and criminality among incarcerated women . -
pubmed
Lower
BDNF levels were associated with
emotional abuse in the forensic group as well as with
sexual abuse in the healthy control group . -
pubmed
After multinomial logistic regression , lower levels of
BDNF , higher levels of
emotional abuse and the presence of familial offense were considered factors related to clinical
psychiatric group . -
pubmed
The results of this study underscore the idea that
BDNF may be an important factor related to the development of diseases and criminality in women who are victims of
childhood trauma , becoming a possible biological marker . -
pubmed
[ Detecting Large Germline Rearrangements of
BRCA1 by Next Generation
Tumor Sequencing ] . -
pubmed
A majority of
BRCA1 / 2 (
BRCA ) pathogenic variants (
PVs ) are single nucleotide substitutions or small insertions / deletions . -
pubmed
The aim of this study was to validate the Next Generation Tumor Sequencing ( NGTS ) technology to detect various gLGRs of
BRCA1 locus in surgical
tumor tissue samples . -
pubmed
In this study , seven different
BRCA1 gLGRs , previously found in
high - grade serous ovarian cancers (
HGSOC ) patients , were detected in
tumor samples collected from the patients at a time of
HGSOC surgery . -
pubmed
This study demonstrated that NGS can accurately detect
BRCA1 gLGRs in primary
tumors , suggesting that gLGR evaluation in
BRCA1 locus should be performed in cases when the screening for
BRCA alterations starts from
tumor instead of blood . -
pubmed
NGS sequencing of
tumor samples may become the preferred method to detect both somatic and germline gLGRs in
BRCA - encoding loci . -
pubmed
In a multivariable regression analysis ,
prematurity , male sex ,
congenital heart disease ,
sepsis , ventilator support , vasopressor receipt , central venous catheter , invasive procedures , and receipt of
erythropoietin were associated with increased risk of
thrombosis , while Black race and Hispanic ethnicity were associated with reduced risk . -
pubmed
The
insulin receptor in
myotonic dystrophy . -
pubmed
Insulin binding was studied using circulating monocytes obtained from seven
patients with
myotonic dystrophy and seven control
subjects . -
pubmed
These results suggest that no abnormality exists in the
insulin receptor in
myotonic dystrophy . -
pubmed
Plasma renin activity was measured in 14 of the
patients with
hypertension . -
pubmed
Inhibitors to
interleukin 1 and
tumor necrosis factor may have therapeutic potential in conditions such as
inflammatory arthritis ,
diabetes mellitus ,
disseminated intravascular coagulopathy and
septic shock . -
pubmed
The ability to modulate host defenses with
cytokines and
cytokine antagonists may also have applications in the fields of transplantation , oncohematology and
immunodeficiency . -
pubmed
Serum aminoterminal propeptide of
type III procollagen in
systemic sclerosis . -
pubmed
Fifty - seven
patients with
systemic sclerosis were investigated for connective tissue turn - over related to
type III collagen . -
pubmed
Sera from 13
patients with diffuse
cutaneous systemic sclerosis and 44
patients with limited
cutaneous systemic sclerosis were analysed for aminoterminal propeptide of
type III procollagen (
PIIINP ) by a radioimmunoassay based on
human propeptide . -
pubmed
Increased levels of
PIIINP in serum correlated with
skin involvement and the clinical course . -
pubmed
All
patients with diffuse
cutaneous systemic sclerosis had levels above the normal range , and in limited
cutaneous systemic sclerosis elevated
PIIINP levels seemed to be correlated with rapid progression and with extension of lesions . -
pubmed
Serum
PIIINP may be utilized as a marker of
type III collagen fibrogenesis in
systemic sclerosis and be of prognostic value . -
pubmed
PIIINP may also be of use in the differential diagnosis between diffuse
cutaneous systemic sclerosis and
scleredema . -
pubmed
The data developed in this study should be applicable to the study of
patients with
hypertension due to apparent mineralocorticoid excess , a deficiency in
11 - HSD activity . -
pubmed
Furthermore , two
murine models appear relevant to the study of late
HIV-1 infection and suggest a role for
CD8 + T cells in the prevention of symptomatic
AIDS . -
pubmed
Geographical distribution of subclinical
autoimmune thyroid disease in Britain : a study using highly sensitive direct assays for autoantibodies to
thyroglobulin and
thyroid peroxidase . -
pubmed
Excluding cases of overt
thyroid disease ( biochemically hypo- or
hyperthyroid with thyroid antibodies ) , the overall prevalences of the antibodies in sera from the 698 female blood donors were 17.8 % for
thyroglobulin antibody and 17.8 % for
thyroid peroxidase antibody . -
pubmed
In contrast , the prevalences of
thyroglobulin antibody and
thyroid peroxidase antibody were 41 and 43 % , respectively , in the 117 female relatives of 18 probands with
autoimmune thyroid disease , but the highest prevalences were observed in groups of women patients with
Graves ' disease ( N = 39 ) or
Hashimoto ' s disease ( N = 39 ) ( 51 , and 97 % for
thyroglobulin antibody , respectively , and 72 and 97 % for
thyroid peroxidase antibody , respectively ) . -
pubmed
In contrast , in a
patient with
hypercortisolism and a preserved circadian rhythm of
cortisol levels , we found the minimum of
IL-1 production at 4:00 p.m. , 8 hours after the maximum
cortisol level was reached . -
pubmed
Furthermore , in 7
patients with
sarcoidosis both spontaneous and LPS - induced
IL-1 production of isolated monocytes were significantly decreased 8 hours after the first injection of
MP ( 1 mg / kg bw i.v . ) -
pubmed
It is suggested that the
hypotensive action of
timolol on intraocular pressure results from structural and functional changes induced on the plasma membranes of the iris - ciliary body and trabecular meshwork by the
thiadiazole group of the molecule , and , also , from the occupation of the
adrenergic receptors of the iris - ciliary body by the
tert - butylamino-2 - hydroxypropoxy part of the compound . -
pubmed
Intravenous
immunoglobulin therapy for
idiopathic thrombocytopenic purpura and other
immune - related disorders : review and update of our experiences . -
pubmed
The former was recently confirmed by the observation that serum and platelet eluates of
patients with
ITP bind to normal platelets , but not to Glanzmann 's thrombasthenic platelets which are deficient in
glycoproteins IIb and IIIa . -
pubmed
The heterogeneity of
ITP is also reflected in the difference in response to
immunoglobulin prepared for intravenous administration ( IVIG ) treatment . -
pubmed
Diagnostic value of a single
serum thyroglobulin determination on and off thyroid suppressive therapy in the follow - up of
patients with
differentiated thyroid cancer . -
pubmed
To assess the significance of a single
serum thyroglobulin (
Tg ) determination on and off thyroid suppressive therapy ,
serum Tg measurements have been performed in 349 serum samples from 82
patients with
differentiated thyroid cancer . -
pubmed
Serum
Tg was undetectable in sera from
patients with no evidence of thyroid residue or
metastatic disease in all but one ( 1.7 % ) of 59 samples on and three ( 5.4 % ) of 56 samples off suppressive therapy . -
pubmed
We describe an equilibrium assay for measuring release of
plasminogen activator form blood - vessel walls and report data from 125
individuals free of overt
thromboembolic disease . -
pubmed
Excess
human plasminogen is added to the
euglobulin fraction of plasma obtained before and after
venous occlusion at mean systolic pressure . -
pubmed
Both antiviral and nonantiviral effects of
interferon are accentuated in cell culture systems utilizing
DS tissue , presumably as a consequence of the localization of the interferon gene(s ) on chromosome 21 . -
pubmed
A study of dosage wastage in
insulin - treated
diabetics ] . -
pubmed
Effect of the aqueous extract of
Cinnamomum Cassia ( CCAq ) on experimental
glomerulonephritis was studied and compared with that of
cobra venom factor (
CoVF ) . -
pubmed
These results suggest that intravenous
adrenomedullin exerts a
hypotensive action that is associated with the attenuated reflex - mediated sympathetic activation . -
pubmed
The production of
macrophage inflammatory protein-1 alpha (
MIP-1 alpha ) , a
chemotactic cytokine which has an important role in vivo for the recruitment of leukocytes to a site of
inflammation , was also significantly inhibited during peak production on Days 4 and 5 of the MLR assay . -
pubmed
To these finding , lesions of the dorsal / ventral hippocampus and amygdala in aged
animals resulted in significantly increased
TSH secretion , while results of
septal lesions were not significant . -
pubmed
Warfarin derivatives exert both their
embryopathic and their fetopathic effects via pharmacologic action : inhibition of gamma carboxylation of
osteocalcin and a similar carboxylation of the
vitamin K dependent clotting factors . -
pubmed
Meanwhile ,
serum transaminases (
GOT and
GPT ) activities were significantly increased by
CCl4 administration , indicating that
liver injury is induced . -
pubmed
The present study demonstrates that hepatic
regucalcin is released into the serum of
rats administered orally
CCl4 , suggesting that the estimation of serum regucalcin is a useful tool for diagnosis of
liver injury . -
pubmed
Interestingly , reduced numbers of macrophages with the phenotype of antigen presenting cells (
monoclonal antibodies RFD1 + RFD7- ) were recorded in the subjects with
bronchial hyperresponsiveness , who also had a significant increase in the proportion of
RFD1 + RFD7 + suppressor macrophages . -
pubmed
The measurement of mare colostral and foal serum
IgG as well as the paramunisation of neonatal and weaned foals are important factors in the prevention of
infectious diseases . -
pubmed
Differential islet cell expression of two
glutamate decarboxylases , both autoantigens in
diabetes . -
pubmed
Recombinant
interferon gamma for the therapy of immunological and
oncological diseases . -
pubmed
In addition , the inhibitory activity of
isothiocyanates for
PROD correlated with the previously demonstrated
tumor inhibitory potency in
( 4 - methylnitrosamino )- 1 -( 3 - pyridyl )- 1 - butanone (
NNK ) induced
A / J mouse lung tumor bioassays , which supports earlier findings that
P450 2B1 is one of the major
isozymes involved in
NNK activation and that inhibition of this
isozyme is an important mechanism for the chemopreventive activity of
isothiocyanates . -
pubmed
The
NF1 gene product ,
neurofibromin , displays partial homology to
GTPase - activating protein (
GAP ) . -
pubmed
The mutations reported in this study therefore provide further material for the functional analysis of
neurofibromin as well as an insight into the mutational spectrum of the
NF1 GRD . -
pubmed
Because
itraconazole , a widely used
mycotic , is a potent inhibitor of
CYP3A4 , we wanted to study a possible interaction between
oxybutynin and
itraconazole . -
pubmed
Leukocyte adhesion deficiency type 1 (
LAD-1)/variant . -
pubmed
A novel
immunodeficiency syndrome characterized by dysfunctional
beta2 integrins . -
pubmed
LAD-1 is characterized by the absence of the
beta2 integrins (
CD11 / CD18 ) on leukocytes . -
pubmed
During follow - up , a
bleeding tendency related to decreased
beta3 activation became clinically apparent , different from previously described
cellular adhesion molecule variants . -
pubmed
Therefore , this is the first well - documented case of a
clinical combined immunodeficiency syndrome that results from nonfunctional
CD11 / CD18 molecules , and thus designated
LAD-1/ variant . -
pubmed
The quality - of - life effects of
interferon beta-1b in
multiple sclerosis . -
pubmed
BACKGROUND : A recombinant form of
interferon beta-1b ( Betaseron ) was given Food and Drug Administration approval for use in the treatment of
relapsing - remitting multiple sclerosis in 1993 based on a documented reduction in exacerbation rate . -
pubmed
OBJECTIVES : To evaluate a recombinant form of
interferon beta-1b in the treatment of
relapsing - remitting multiple sclerosis and to discuss treatment trade - offs and comprehensive quality - of - life ( QOL ) outcomes . -
pubmed
METHODS : We present a randomized evaluation of treatment with a recombinant form of
interferon beta-1b in 79
patients with
multiple sclerosis who participated in a random allocation lottery and were followed up for 12 months , during which data on QOL and clinical outcomes were collected . -
pubmed
These results suggest that ICM - derived antibodies can be used to map surface - accessible epitopes on
MSP-1 and that the recombinant fragments with which they react are appropriate candidates for further evaluation as components of a
malaria vaccine . -
pubmed
Insulin dose adjustment by
diabetes specialist nurses is common practice but its legality is questionable . -
pubmed
These enzymatic pathways may contribute to a complex relationship between the
hypertensive actions of
Ang II and various vasodepressor peptides from either the
renin -
angiotensin system or other peptide systems . -
pubmed
administration , which can be of clinical interest especially in
patients with
kidney insufficiency who are treated with
GLP-1 . -
pubmed
Wnt signaling induces
GLT-1 expression in
rat C6 glioma cells . -
pubmed
Because expression of the
Wnt-1 protooncogene results in induction of the glial - type
glutamate transporter
GLAST in
PC12 neuron - like cells , we have evaluated the effect of
Wnt-1 - induced signaling on
glutamate transporter expression in
rat C6 glioma cells . -
pubmed
Because cytogenetic studies frequently identify chromosome 5 and 17 deletions within a single clone , we searched for allele loss for 5q loci and
TP53 gene mutations in the same
leukemic samples . -
pubmed
Cosegregating deletions of chromosomes 5 and 17 were found to specifically include the 5q13.3 interval between the loci D5S672 and D5S620 / D5S626 , a locus hypothesized to harbor a
tumor suppressor gene(1 ) and the
TP53 gene on 17p . -
pubmed
Our findings are consistent with functional cooperation between a putative
tumor suppressor gene at 5q13.3 that contributes toward the progression of early stages of
MDS , and the
TP53 gene when mutated , causes transformation to
AML . -
pubmed
The meconium group 's bowel showed serosal thickening ,
inflammation , focal fibrin , and
collagen deposits . -
pubmed
To investigate the role of passive cell death pathway in
EAE , we used
mice with transgenic expression of the long form of the
bcl - x gene (
Bcl - x ( L ) ) targeted to the T - cell lineage . -
pubmed
We found that
mice transgenic for
Bcl - x ( L ) have an earlier onset and a more chronic form of
EAE induced by
myelin oligodendrocyte glycoprotein (
MOG ) peptide 35 - 55 compared with wild - type littermate
mice . -
pubmed
This is the first report of an
autoimmune disease model in
Bcl - x ( L ) transgenic
mice . -
pubmed
Kawasaki disease on
PDGF expression and VSMC proliferation . -
pubmed
The effect of serum of
patients with
Kawasaki disease (
KD ) on expression of
platelet - derived growth factor ( PDGF ) B chain protein in vascular endothelial cells ( VEC ) was studied by immunocytochemical method . -
pubmed
The results showed that the serum of
patients with
KD induced the expression of
PDGF - B chain protein significantly . -
pubmed
These data suggest that the activation of
PDGF - PDGF receptor may play a role in the pathogenesis of coronary complication of
KD . -
pubmed
In some patients , association of
ataxia with specific serum antibodies (
antigliadin ,
antiglutamic acid decarboxylase ) suggests an immune pathogenesis . -
pubmed
In vivo , all the isolated
myotoxins induced release of
creatine kinase due to
necrosis of muscle fibers , accompanied by polymorphonuclear cell infiltration , and
edema in the
mouse paw . -
pubmed
The
myotoxic and cytotoxic activities of
BthTX - I , a Lys49 PLA(2 ) homologue , after modification by
BPB , RB , NBSF and NPSC , were reduced to 50 % , 20 % , 75 % , 65 % and 13 % , 0.5 % , 76 % , 58 % , respectively . -
pubmed
BPB - treated
BthTX - II , an Asp49 PLA(2 ) homologue , lost most of its catalytic , indirect hemolytic , anticoagulant ,
myotoxic and cytotoxic activities . -
pubmed
The 80
patients , aged 1 mo , were divided into two groups based on the initial
thyroid stimulating hormone (
TSH ) and free
thyroxine ( FT4 ) values : a mild - moderately
hypothyroid (
MHT ) group ( n = 64 , 31 M and 33F ) and a severely
hypothyroid (
SHT ) group ( n = 16 , 3 M and 13F ) . -
pubmed
Although serum
creatinine kinase levels were significantly higher in the SHT group ( 230.3+/-102.3 U / L , p & lt ; 0.001 ) than in the MHT group ( 121.1+/-60.8 U / L ) ,
rhabdomyolysis was not considered to be responsible for the
impaired renal function . -
pubmed
The
fractalkine levels in ejaculates from normal donors and infertile male
patients with or without
asthenozoospermia , were examined and correlated with sperm motility and morphology . -
pubmed
Fractalkine titres in the seminal plasma of infertile
men with
asthenozoospermia ( 0.64 + /- 0.04 microg / ml ; n = 58 ) were lower than those in
patients without
asthenozoospermia ( 0.94 + /- 0.10 microg / ml ; n = 22 , P & lt ; 0.01 ) and fertile donors ( 1.04 + /- 0.07 microg / ml ; n = 10 , P & lt ; 0.001 ) . -
pubmed
There was no significant difference between
fractalkine levels in
patients with and without
leukospermia . -
pubmed
Men and Blacks have a higher
albumin excretion rate than do women and Whites and may thereby have an increased risk of
microvascular and macrovascular disease . -
pubmed
Vanadium increases
GLUT4 in
diabetic rat skeletal muscle . -
pubmed
The response to
BMOV by oral gavage was rapid and the
animals were normoglycemic within 24 h of treatment and still demonstrated a significant effect even after 72 h. Using a specific antibody against
GLUT4 we found an overall reduction in the
GLUT4 in the total membrane fraction in skeletal muscle of
diabetic animals . -
pubmed
This is the first report that establishes a direct effect of
vanadium on the regulation of
GLUT4 expression in
diabetic animals in vivo , and may at least partially explain the glucoregulatory effects of
vanadium . -
pubmed
Safety and efficacy of
recombinant factor VIIa in
patients with
liver disease undergoing laparoscopic liver biopsy . -
pubmed
METHODS : By establishing
D - galactosamine - induced
rat liver fibrosis model , we observed the effect of
oxymatrine on serum and tissue biochemical indexes , content of liver
hydroxyline , expression of
TGF ? - pubmed
BIII-890 - CL is a non - orally active
sodium channel blocker under development by Boehringer Ingelheim Corp for the potential treatment of
thromboembolic stroke . -
pubmed
[
Tropomyosin in
myoma tissue ] . -
pubmed
[ Effects of
Oxymatrine on the expression of
tissue inhibitor of metalloproteinase-1 and
alpha - smooth muscle actin in the livers of
rats with
hepatic fibrosis ] . -
pubmed
Cholestasis develops during inflammatory conditions characterized by the release of
cytokines like
interleukin-6 (
IL-6 ) , which is the major player in the hepatic acute - phase response . -
pubmed
IL-6 is required for transporter down - regulation during
aseptic inflammation . -
pubmed
Furthermore ,
IL-6 also contributes to transporter regulation during LPS - induced
cholestasis at more delayed time points . -
pubmed
Functional
COMT variant predicts response to high dose
pyridoxine in
Parkinson ' s disease . -
pubmed
In this study , we examined the effect of the
COMT ( L ) allele on the clinical response to
pyridoxine in
Parkinson ' s disease (
PD )
patients . -
pubmed
Our observational study suggests that the status the functional
COMT ( L ) variant may be potentially useful to select
PD patients for high dose
pyridoxine therapy . -
pubmed
A second
lactose tolerance test involving 10 g and 30 g of
lactose was carried out in 10 subjects showing resistance to
diarrhea , and serum
glucose and
insulin levels and the amount of
hydrogen excreted in the breath were measured for comparison with those of
glucose and
lactitol . -
pubmed
BACKGROUND : Although maternal
anaemia often stems from
malaria infection during pregnancy , its effects on foetal
haemoglobin levels are not straightforward . -
pubmed
Lower - than - expected cord
haemoglobin values in malarious versus non - malarious regions were noted by one review , which hypothesized they resulted from foetal immune activation to
maternal malaria . -
pubmed
This study addressed this idea by examining cord
haemoglobin levels in relation to
maternal malaria ,
anaemia , and markers of foetal immune activation . -
pubmed
METHODS : Cord
haemoglobin levels were examined in 32
malaria - infected and 58 uninfected women in Blantyre , Malawi , in relation to maternal
haemoglobin levels ,
malaria status , and markers of foetal haematological status ,
hypoxia , and
inflammation , including
TNF - alpha ,
TGF - beta , and
ferritin . -
pubmed
RESULTS : Although
malaria was associated with a reduction in maternal
haemoglobin ( 10.8 g / dL vs. 12.1 g / dL , p & lt ; 0.001 ) , no reduction in cord
haemoglobin and no significant relationship between maternal and cord
haemoglobin levels were found . -
pubmed
Maternal
malaria was associated with decreased
TGF - beta and increased cord
ferritin , the latter of which was positively correlated with
parasitaemia ( r = 0.474 , p = 0.009 ) . -
pubmed
Increased cord
ferritin was associated with significantly decreased birth weight and gestational length , although maternal and cord
haemoglobin levels and
malaria status had no effect on birth outcome . -
pubmed
CONCLUSION : In this population , cord
haemoglobin levels were protected from the effect of
maternal malaria . -
pubmed
However , decreased
TGF - beta and elevated
ferritin levels in cord blood suggest foetal immune activation to
maternal malaria , which may help explain poor birth outcomes . -
pubmed
However , no studies have focused on determining the change in (
Na (+)/ K (+)) ATPase isoforms caused by chronic exposure to
aluminum and its relation with
aluminum toxicity . -
pubmed
Macrophage inhibitory cytokine-1 H6D polymorphism ,
prostate cancer risk , and survival . -
pubmed
Macrophage inhibitory cytokine-1 (
MIC-1 ) , a member of the
transforming growth factor - beta superfamily , is important in regulating
inflammation . -
pubmed
A recent study ( JNCI 2004 , 96:1248 - 1254 ) found marginal evidence of an association between the presence of the mature
MIC-1 protein nonsynonymous polymorphism H6D C - to - G ( rs1058587 ) with reduced
prostate cancer risk [ odds ratio , 0.83 ; 95 % confidence interval ( 95 % CI ) , 0.69 - 0.99 ] . -
pubmed
Our data suggest that the H6D variant in
MIC-1 might play a role in
prostate cancer , but it is difficult to explain how a variant can be associated with lower risk of developing
prostate cancer but more aggressive growth if
cancer develops . -
pubmed
On the molecular basis linking
Nerve Growth Factor (
NGF ) to
Alzheimer ' s disease . -
pubmed
This assertion has been at the basis of the hypothesis developed in the last 20 years , whereby
NGF deprivation would be one of the factor involved in the etiology of sporadic forms of
AD . -
pubmed
In this review , we shall summarize data that lead to the production and characterization of a
mouse model for
AD ( AD11 anti -
NGF mice ) , based on the expression of transgenic antibodies neutralizing
NGF . -
pubmed
The
AD - like phenotype of AD11
mice will be discussed on the basis of recent studies that have posed
NGF and its precursor pro - NGF back to the stage of
AD - like neurodegeneration , showing the involvement of the precursor pro - NGF in one of the cascades leading to
AD neurodegeneration . -
pubmed
Some studies suggest that
angiotensin II may influence some cellular pathways that contribute to the pathogenesis of
IR and stimulate the release of
proinflammatory cytokines . -
pubmed
Fifty - two
patients who had stages 3 and 4
CKD and no
diabetes were administered an
angiotensin receptor blocker ( ARB ) ,
olmesartan ( 40 mg ) , for 16 wk . -
pubmed
Compared with control subjects ,
patients with
CKD presented significantly higher BP and waist circumference , higher
triglycerides and lower
HDL levels , higher
insulin levels , and higher mean HOMA index ( 6.0 + /- 2.7 versus 2.9 + /- 2.2 muU / ml x mmol / L ; P & lt ; 0.001 ) . -
pubmed
In addition ,
patients with
CKD had increased levels of high - sensitivity
C - reactive protein ,
TNF - alpha , and
IL-6 . -
pubmed
In
patients with
CKD ,
leptin was positively correlated to
abdominal obesity ,
insulin levels , and
IL-6 , and
adiponectin was inversely correlated to
abdominal obesity and
insulin levels . -
pubmed
Acquired chromosomal rearrangements targeting selected
transcription factors : contribution of molecular cytogenetic and expression analyses to the identification of clinically and biologically relevant subgroups in
hematological malignancies . -
pubmed
In
leukemias characterized by 11q23 amplification , we described the amplicon and confirmed MLL , in addition to
DDX6 , as a principal amplification target . -
pubmed
Molecular characterization of a large series of unselected sporadic and recurrent 3q26 rearranged
leukemias confirmed the decisive role of ectopic
EVI1 expression in these malignancies . -
pubmed
We contributed to an extensive analysis of the phenotypical and prognostic features of
T - ALL characterized by
HOX11L2 expression and identified
HOX11L2 overexpression as one of the most frequent
genetic defects in childhood
T - ALL , associated with intermediate prognosis . -
pubmed
Beta - interferon protects
multiple sclerosis patients against enhanced susceptibility to
infections caused by poor air quality . -
pubmed
METHODS : The relapse rates of
beta - interferon users and nonusers were compared to ambient air inhalable particle levels and
viral infections in the population with logistic regression . -
pubmed
PM(10 ) and
virus infections had no significant effects in
interferon users . -
pubmed
CONCLUSION : In addition to being antiviral ,
interferon also protected
multiple sclerosis patients against an enhanced susceptibility to
infections caused by PM(10 ) . -
pubmed
123I - ADAM SPECT imaging of
serotonin transporter binding in
patients with
night eating syndrome : a preliminary report . -
pubmed
Using knockout
mice , we have also shown that
TNF - alpha and both
TNFR1 and
TNFR2 are required for optimal control of
B. - pubmed
The therapeutic benefits of
interferon - beta are limited , as some patients with
multiple sclerosis (
MS ) do not respond to therapy . -
pubmed
Protein misfolding inside cells : the case of
huntingtin and
Huntington ' s disease . -
pubmed
Milk fat globule epidermal growth factor - factor VIII is down - regulated in
sepsis via the lipopolysaccharide -
CD14 pathway . -
pubmed
We have previously shown that the administration of
MFG - E8 - rich exosomes from immature dendritic cells promotes the phagocytosis of apoptotic cells and improves survival in
sepsis . -
pubmed
Because endotoxin is elevated in
polymicrobial sepsis , we hypothesized that down - regulation of
MFG - E8 is mediated via the LPS -
CD14 pathway , eventually leading to the accruement of apoptotic cells . -
pubmed
Polymicrobial sepsis was induced by cecal ligation and puncture ( CLP ) in
CD14 - deficient (
CD14(-/- ) ) ,
TLR4 - mutated and wild - type ( WT )
mice . -
pubmed
Thus ,
MFG - E8 production is down - regulated in
sepsis by LPS -
CD14 dependent fashion , leading to a reduction of phagocytosis of apoptotic cells . -
pubmed
Nutlin-3 is a
MDM2 inhibitor under preclinical investigation as nongenotoxic activator of the
p53 pathway for
cancer therapy . -
pubmed
Primary testicular presentation of
ALK-1 - negative
anaplastic large cell lymphoma in a pediatric
patient . -
pubmed
Regarding "
C - reactive protein (
CRP ) elevation in patients with
abdominal aortic aneurysm " . -
pubmed
RECENT FINDINGS : Recent novel and promising findings include additional abnormalities in key pathways associated with thyroid tumorigenesis (
RET - Ras -
BRAF -
MEK ;
RET -
beta - cateinin ;
TRK -
PI3K -
AKT ; and
MDM - p53 - PTEN ) , single - nucleotide polymorphisms associated with
thyroid cancer susceptibility , epigenetic silencing , alternative splicing , and gene expression abnormalities . -
pubmed
Several studies indicate the involvement of
protein kinases in the progression of various
malignancies . -
pubmed
CK2 kinase (
casein kinase-2 ) has been suggested to be a constituent of a neoplastic milleu , and its inhibition might represent a new approach to
cancer therapy . -
pubmed
We have examined the effects of
2 - dimethylamino-4,5,6,7 - tetrabromobenzimidazole (
DMAT ) , a potent
CK2 inhibitor , on the
H295R human adrenocortical cancer cell line . -
pubmed
Nrf2 is a major transcriptional stimulator of cytoprotective genes and is critical for
cancer prevention . -
pubmed
Increased hepatic
insulin action in diet - induced
obese mice following inhibition of
glucosylceramide synthase . -
pubmed
We have previously shown that a specific inhibitor of
glucosylceramide synthase , which inhibits the initial step in the synthesis of glycosphingolipids ( GSLs ) , improved
glucose metabolism and decreased
hepatic steatosis in both ob / ob and diet - induced
obese ( DIO )
mice . -
pubmed
CONCLUSIONS / SIGNIFICANCE : These results indicate that
GSL inhibition in
obese mice primarily results in an increase in
insulin action in the liver , and suggests that GSLs may have an important role in hepatic
insulin resistance in conditions of
obesity . -
pubmed
Immunohistochemical localization of
glutathione s - transferase isoenzymes (
gsta ,
Gstp ,
Gstm4 , And
Gstt1 ) and
tumour marker
p53 in matched tissue from
normal larynx and
laryngeal carcinoma : correlations with prognostic factors . -
pubmed
OBJECTIVE : The immunohistochemical staining characteristics of
glutathione S - transferase ( GST ) alpha (
GSTA ) ,
pi (
GSTP ) ,
mu (
GSTM4 ) , and
theta (
GSTT1 ) and
P53 were investigated in
laryngeal squamous cell carcinoma (
LSCC ) cases and
normal laryngeal tissue from 46
patients . -
pubmed
The relationship between expression of the
GST isoenzymes and
P53 in
normal and
tumour tissue was analyzed using the Wilcoxon signed rank test . -
pubmed
RESULTS : When the
normal and
tumour tissues of these cases were compared according to their staining intensity and percentage of positive staining ,
GSTA expression in
normal cells was significantly higher than in
tumour cells , and
GSTP and
P53 expression was higher in
tumour cells ( p & lt ; .05 ) . -
pubmed
GSTM and
GSTT1 expression was higher in
normal cells ; however , the statistical significance was low ( p & gt ; .05 ) . -
pubmed
There was no correlation between
P53 and
GST expression in
patients with
LSCC . -
pubmed
When the immunohistochemical results of
GST isoenzymes and
P53 were correlated with the clinical parameters ,
GSTA expression was increased in poorly differentiated
laryngeal tumour , but
GSTM4 and
GSTT1 expression was decreased ( p & lt ; .05 ) . -
pubmed
CONCLUSION : According to these results ,
GST - A , - P , and
T1 and
P53 were important in the diagnosis of
LSCC . -
pubmed
Erythropoietin - driven proliferation of cells with mutations in the
tumor suppressor gene
TSC2 . -
pubmed
Lymphangioleiomyomatosis (
LAM ) is characterized by
cystic lung destruction , resulting from proliferation of smooth - muscle - like cells , which have mutations in the
tumor suppressor genes
TSC1 or
TSC2 . -
pubmed
Because high red cell indexes could result from
hypoxemia - induced
erythropoietin (
EPO ) production , and
EPO is a smooth muscle cell mitogen , we investigated effects of
EPO in
human cells with genetic loss of
tuberin function , and we found that
EPO increased proliferation of
human TSC2-/- , but not of
TSC2+/- , cells . -
pubmed
Although the high red cell mass of
LAM patients could be related to advanced disease , we propose that
EPO , synthesized in response to episodic
hypoxia , may increase disease progression by enhancing the proliferation of LAM cells . -
pubmed
The influence of intracerebroventricullary - administered
urocortin-2 , a selective
corticotropin - releasing factor receptor 2 (
CRF ( 2 ) ) agonist , on
rat anxiety - like behaviour , the expression of
c - Fos and
CRF , and plasma
corticosterone levels was examined in the present study . -
pubmed
These data suggest a role of
urocortin-2 in the behavioural and immunocytochemical responses to stress , in which it strengthens the measures of
anxiety - like responses . -
pubmed
Indeed ,
PRL administration to ovariectomised
rats significantly diminishes the deleterious effects of KA in the dorsal hippocampus and reduces the progression of KA - induced
seizures . -
pubmed
Despite the withdrawal of the first generation of
cannabinoid type 1 receptor (
CB1 ) antagonists from the pharmaceutical market due to the occurrence of psychiatric adverse events , new evidence suggests that peripherally restricted
CB1 antagonists might be efficacious for the treatment of
obesity and its associated
metabolic disorders . -
pubmed
Ours results show the therapeutic importance of
DA D ( 1 ) agonist in stress - induced dopaminergic - related
neurological disorders . -
pubmed
Neuroinflammatory
Cytokines - The Common Thread in
Alzheimer ' s Pathogenesis . -
pubmed
This article discusses the potential role of the
cytokine cycle and its corollary as drivers of the relentless progression of
Alzheimer ' s neuropathologies , whether they are the result of gene mutations , gene polymorphisms , and/or environmental and comorbid conditions . -
pubmed
Based on the discovery of
cytokine overexpression as an accompaniment to the
dementia - related glial activation , the
cytokine hypothesis was proposed . -
pubmed
This , together with demonstration of
IL-1 induction of excessive production of the precursors of other features common in
AD prompted a corollary to the
cytokine hypothesis . -
pubmed
The corollary states that regardless of the primary cause of the neuronal insult , the result will be chronic glial activation , which in turn will result in further
neuronal injury , still more glial activation with excess
cytokine expression and so on . -
pubmed
Relation of systemic and urinary
neutrophil gelatinase - associated lipocalin levels to different aspects of
impaired renal function in
patients with acute decompensated
heart failure . -
pubmed
Both urine and
serum neutrophil gelatinase - associated lipocalin (
NGAL ) reflect active
chronic kidney disease and predict
acute kidney injury . -
pubmed
We prospectively evaluated 93
patients admitted with acute decompensated
heart failure and treated with intravenous
furosemide and measured both systemic ( serum ) and urine
NGAL levels and their corresponding markers of estimated glomerular filtration rate , natriuresis ( urine
sodium ) , and diuretic response ( net output , urine
sodium /
furosemide ratio ) . -
pubmed
Both markers predicted
acute kidney injury ( urine
NGAL , odds ratio 1.7 , p = 0.035 ; serum
NGAL , odds ratio 1.9 , p = 0.009 ) . -
pubmed
In conclusion , in
patients with acute decompensated
heart failure , urine
NGAL levels reflect
renal distal tubular injury with impaired natriuresis and diuresis , and systemic
NGAL levels demonstrate a stronger association with glomerular filtration function . -
pubmed
We further determined frontal cortex and hippocampal levels of oxidatively generated nuclear DNA damage , as measured by
oxoguanine DNA glycosylase and
formamidopyrimidine DNA glycosylase sensitive sites detected by the comet assay , as well as the expression of genes involved in DNA repair (
Ogg1 and
Nudt1 ) and
inflammation (
Ccl2 and
Tnf ) . -
pubmed
Analysis of
vesicular monoamine transporter 2 polymorphisms in
Parkinson ' s disease . -
pubmed
Polymorphisms in
VMAT2 gene and in its regulatory regions might therefore serve as genetic risk factors for
PD . -
pubmed
In the present study , we have analyzed 8 single - nucleotide polymorphisms ( SNPs ) located within / around the
VMAT2 gene for association with
PD in an Italian cohort composed of 704
PD patients and 678 healthy controls . -
pubmed
This study adds to the previous evidence suggesting that variability in
VMAT2 promoter region may confer a reduced risk of developing
PD , presumably via mechanisms of gene overexpression . -
pubmed
Presence of the
JAK2 V617F mutation in a patient with
chronic neutrophilic leukemia and effective response to
interferon alpha-2b . -
pubmed
Chronic neutrophilic leukemia (
CNL ) is a rare type of
leukemia characterized by a proliferation mainly of mature neutrophils , elevated
neutrophil - alkaline phosphatase activity , and no presence of the Philadelphia chromosome . -
pubmed
The
JAK2 V617F mutation has been detected in patients with classical
myeloproliferative disorders (
MPD ) including
polycythemia vera and
essential thrombocythemia and
idiopathic myelofibrosis . -
pubmed
In contrast , this same mutation has been detected in only 4 patients with
CNL to date , suggesting that the
JAK2 V617F mutation is a rare event in patients with atypical
MPD . -
pubmed
Here , we report a case of
CNL with presence of the
JAK2 V617F mutation . -
pubmed
Finally , virulence studies in a
murine sepsis model revealed attenuated virulence of the
hpd1 mutant , which indicates generation of
propionyl - CoA from host - provided nutrients during
infection . -
pubmed
Expression of
human chorionic gonadotropin in
testicular germ cell tumors . -
pubmed
BACKGROUND : We have shown that most
patients with
seminomas have elevated serum concentrations of the free beta subunit of
human chorionic gonadotropin (
hCGbeta ) and that in
nonseminomatous testicular cancer , most of the
hCG in the serum is hyperglycosylated (
hCG - h ) . -
pubmed
However , the tissue expression of
hCG - h or
hCGbeta in
germ cell tumors (
GCTs ) has not been reported . -
pubmed
Our objective was to study the expression and diagnostic value of
hCG - h and
hCGbeta in
testicular GCTs . -
pubmed
METHODS : We studied the immunohistochemical expression of
hCG ,
hCG - h ,
hCGbeta , and the free
alpha subunit of hCG (
hCGalpha ) in
GCTs from 154
patients . -
pubmed
All forms of
hCG , including
hCG - h , were detected in
embryonal carcinomas ( 22 % ) and mixed
GCTs ( 48 % ) . -
pubmed
Polyclonal
hCG and monoclonal
hCGbeta antibodies detected immunoreactivity in some
seminomas ( 7 % ) . -
pubmed
No form of
hCG was found in
spermatocytic seminomas , pure
teratomas , or a
yolk sac tumor . -
pubmed
CONCLUSION : Trophoblastic tissue expresses
hCG ,
hCG - h , and free subunits together whereas
seminoma tissue occasionally expresses
hCGbeta . -
pubmed
Lithium induces
microcysts and
polyuria in adolescent
rat kidney independent of
cyclooxygenase-2 . -
pubmed
It was hypothesized that renal
cyclooxygenase-2 (
COX-2 ) activity promotes microcyst formation and
NDI . -
pubmed
Lithium treatment induced
somatic growth retardation , renal microcysts and dilatations in cortical collecting duct ; it increased cortical cell proliferation and inactive
pGSK-3beta abundance ; it lowered
aquaporin-2 (
AQP2 ) protein abundance and induced
polyuria with decreased ability to concentrate the urine ; and it increased
COX-2 protein level in thick ascending limb . -
pubmed
Concomitant treatment with
lithium and a specific
COX-2 inhibitor ,
parecoxib ( 5 mg / kg per day , P10 - P34 ) , did not prevent
lithium - induced
microcysts and
polyuria , but improved urine concentrating ability transiently after a
1 - desamino-8 - D - arginine vasopressin challenge . -
pubmed
In chronic
lithium - treated adolescent
rats ,
COX-2 is not colocalized with microcystic epithelium , mitotic activity , and inactive
pGSK-3beta in collecting duct ; a blocker of
COX-2 does not prevent cell proliferation ,
cyst formation , or
GSK-3beta inactivation . -
pubmed
It is concluded that
COX-2 activity is not the primary cause for
microcysts and
polyuria in a
NaCl - substituted
rat model of
lithium nephropathy . -
pubmed
Discovery of
( S )- 1 -( 1 -( Imidazo [ 1,2 - a ] pyridin-6 - yl ) ethyl )- 6 -( 1 - methyl-1H - pyrazol-4 - yl )- 1H -[ 1,2,3 ] triazolo [ 4,5 - b ] pyrazine (
volitinib ) as a highly potent and selective
mesenchymal - epithelial transition factor (
c - Met ) inhibitor in clinical development for treatment of
cancer . -
pubmed
HGF /
c - Met signaling has been implicated in
human cancers . -
pubmed
Our transcriptome - wide identification of retained introns in
SNW1- and
PRPF8 - depleted cells may help to understand the aetiology of diseases associated with splicing defects , such as
retinosa pigmentosum and
cancer . -
pubmed
Nuclear
TDP-43 causes
neuronal toxicity by escaping from the inhibitory regulation by hnRNPs . -
pubmed
Dysregulation of
transactive response DNA - binding protein-43 (
TDP-43 ) is thought to be linked to the pathogenesis of
amyotrophic lateral sclerosis (
ALS ) and
frontotemporal lobar degeneration (
FTLD ) . -
pubmed
TDP-43 normally localizes in the nucleus but its main localization shifts to the cytoplasm in most affected cells of
ALS and
FTLD patients . -
pubmed
It is not yet known whether nuclear or cytoplasmic
TDP-43 is responsible for
TDP-43 - induced
neurotoxicity . -
pubmed
In this study , we show that nuclear
TDP-43 causes
TDP-43 neurotoxicity . -
pubmed
Moreover , endogenous
heterogeneous nuclear ribonucleoprotein - U (
hnRNP - U ) binds to
TDP-43 and knocking - down of
hnRNP - U induces
neurotoxicity , whereas overexpression of
hnRNP - U or
hnRNP - A2 inhibits
TDP-43 - induced
neurotoxicity . -
pubmed
Altogether , these results suggest that nuclear
TDP-43 becomes
neurotoxic by escaping from the inhibitory regulation by hnRNPs . -
pubmed
Mitochondrial
iron accumulation exacerbates
hepatic toxicity caused by
hepatitis C virus core protein . -
pubmed
Functional
EpoR pathway utilization is not detected in primary
tumor cells isolated from
human breast , non - small cell lung , colorectal , and ovarian
tumor tissues . -
pubmed
To test this hypothesis and examine if
human tumors utilize the
erythropoietin receptor pathway , the response of
tumor cells to
human recombinant erythropoietin was investigated in disaggregated
tumor cells obtained from 186
patients with
colorectal , breast , lung , ovarian , head and neck , and other tumors . -
pubmed
A cocktail of well characterized
tumor growth factors (
EGF ,
HGF , and
IGF-1 ) were analyzed in parallel as a positive control to determine whether freshly - isolated
tumor cells were able to respond to
growth factor activation ex vivo . -
pubmed
Exposing
tumor cells to the growth factor cocktail resulted in stimulation of survival and proliferation pathways as measured by an increase in phosphorylation of the downstream signaling proteins
AKT and
ERK . -
pubmed
In contrast , no activation by
human recombinant erythropoietin was observed in isolated
tumor cells . -
pubmed
Though
tumor samples exhibited a broad range of cell - surface expression of
EGFR ,
c - Met , and
IGF-1R , no
cell - surface erythropoietin receptor was detected in
tumor cells from the 186
tumors examined ( by flow cytometry or Western blot ) . -
pubmed
Circulating miR-150 has been recently proposed as a better biomarker of
HF than traditional clinical markers such as
brain natriuretic peptide . -
pubmed
The cardioprotective roles of miR-150 during
ischaemic injury were in part attributed to direct repression of the pro - apoptotic genes
egr2 (
zinc - binding transcription factor induced by
ischaemia ) and
p2x7r (
pro - inflammatory ATP receptor ) in cardiomyocytes . -
pubmed
Although expression and function of
HSPA2 is mainly associated with spermatogenesis , recent studies demonstrated that in
humans , the gene is active in various
cancers , as well as in normal tissues , albeit in a cell type - specific manner . -
pubmed
This study was aimed at determining whether
HIF-1 and its binding site , the
hypoxia - response element ( HRE ) located in the
HSPA2 promoter , are involved in
HSPA2 regulation . -
pubmed
Using an in vitro gene reporter assay , we demonstrated that in keratinocytes
HSPA2 promoter activity is reduced under conditions that facilitate stabilization of
HIF-1alpha , whereas
HIF-1 inhibitors abrogated the suppressive effect of
hypoxia on promoter activity . -
pubmed
In keratinocytes , hypoxia or overexpression of a stable form of
HIF-1alpha attenuated the expression of endogenous
HSPA2 , whereas targeted repression of
HIF-1alpha by RNAi increased transcription of
HSPA2 under
hypoxia . -
pubmed
Conversely , in
HeLa cells ,
HSPA2 expression increased under conditions that stimulated
HIF-1alpha activity , whereas inhibition of
HIF-1alpha abrogated
hypoxia - induced up - regulation of
HSPA2 expression . -
pubmed
Additionally , we also showed that
HSPA2 expression can be stimulated during
hypoxia / reoxygenation stress . -
pubmed
Finally , FA could overload energy homeostasis via increased hypothalamic
ceramide synthesis which could , in turn , contribute to the pathogenesis of
diabetes of
obesity and/or type 2 in predisposed
individuals by disrupting the endocrine signaling pathways of
insulin and/or
leptin . -
pubmed
RESULTS : Compared with healthy
volunteers ,
patients with
DLBCL had significantly higher leukocyte and monocyte counts ( P & lt ; .001 ) ; higher percentages of neutrophils ( P & lt ; .001 ) , " natural " regulatory T cells ( Tregs ;
CD3+
Foxp3 + , P & lt ; .001 ) , and immature DCs (
CD83 -
CD1a+ , P = .005 ) ; and lower percentages of lymphocytes ( P & lt ; .001 ) and helper T cells ( P = .038 ) . -
pubmed
Interferon - inducible GTPase : a novel viral response protein involved in
rabies virus infection . -
pubmed
Several studies have shown that
interferon - inducible GTPases are involved in many biological processes , such as
viral infection , endoplasmic reticulum stress response , and autophagy . -
pubmed
These findings indicate that
interferon - inducible GTPases are likely to be a potential target involved in
rabies pathogenesis or the antiviral process . -
pubmed
The degradation and accumulation of eosinophils , release of
cytokines , and mucus secretion have important roles in the pathogenesis of
ECRS . -
pubmed
This review describes the clinical course , diagnosis , and treatment of
ECRS as well as its pathophysiology and the role of eosinophils , mucus ,
cytokines , and other mediators in the pathogenesis of
ECRS . -
pubmed
Mycoplasma bovis MBOV _ RS02825 Encodes a
Secretory Nuclease Associated with
Cytotoxicity . -
pubmed
This study aimed to determine the activity of one
Mycoplasma bovis nuclease encoded by
MBOV_RS02825 and its association with
cytotoxicity . -
pubmed
MAP kinase (
MPK ) cascades in
Arabidopsis thaliana and other vascular plants are activated by developmental cues , abiotic stress , and
pathogen infection . -
pubmed
Serum
Calprotectin Expression as a Diagnostic Marker for
Sepsis in Postoperative Intensive Care Unit
Patients . -
pubmed
The research was performed to explore the diagnosis value of dynamic
serum calprotectin (
SC ) expression for
sepsis in postoperative intensive care unit
patients . -
pubmed
The effect of
TMEFF2 methylation on the
tumor stage and survival outcome of
clear cell renal cell carcinoma . -
pubmed
AIM : This study aimed to investigate the methylation status of
EGF - like and two
follistatin - like domains 2 (
TMEFF2 ) promoter and its correlation with
tumor stage and survival outcome in
renal cell carcinoma (
RCC ) . -
pubmed
MATERIALS AND METHODS : Paraffin - embedded specimens from 42
RCC patients were analyzed for
TMEFF2 methylation by methylation - specific polymerase chain reaction . -
pubmed
CONCLUSION : These findings showed that
TMEFF2 methylation is not rare in
RCC , and methylation may play an important role in the tumorigenesis of
ccRCC . -
pubmed
Randomized Trial of the Effect of
Magnesium Sulfate Continuous Infusion on
IL-6 and
CRP Serum Levels Following
Abdominal Aortic Aneurysm Surgery . -
pubmed
In this study , we aimed to investigate the impact of
Mg loading following AAA surgery on two
inflammation markers ,
IL-6 and
CRP , as well as
patient 's outcome . -
pubmed
The MOF - UCNP core - satellite superstructures also induce strong cell
cytotoxicity against cancer cells , which are further enhanced by attaching
epidermal growth factor receptor targeting affibodies to the PDT clusters , highlighting their promise as theranostic photodynamic agents . -
pubmed
Long non - coding RNA
NEAT1 overexpression is associated with unfavorable prognosis in
patients with
hepatocellular carcinoma after hepatectomy : A Chinese population - based study . -
pubmed
RESULTS : For the entire cohort of 86
patients , we showed that the expression level of
NEAT1 was significantly higher in
HCC tissues compared with
non - tumorous tissues and
NEAT1 was increased obviously in the
HCC cell lines including
SMMC-7721 ,
Huh-7 and
Hep3B ( P & lt ; 0.001 ) . -
pubmed
CONCLUSIONS : In this study , we found
NEAT1 expressed significantly higher in
HCC tissues compared with
non - tumorous tissues . -
pubmed
INTRODUCTION : To compare the percentage of arterial
oxygen saturation ( SpO2 ) in healthy teeth with confirmed pulp vitality between individuals with
sickle cell anemia (
HbSS ) and normal
hemoglobin A (
HbAA ) . -
pubmed
Furthermore expression of the enzyme responsible for
PGD2 synthesis (
hematopoietic prostaglandin D synthase ,
HPGDS ) was increased in
obese adipose tissues and remained high after
weight loss . -
pubmed
Increased
HPGDS expression was also observed in
human adipose tissues obtained from
obese compared with lean
individuals . -
pubmed
Influence of
LGALS3 gene polymorphisms on susceptibility and prognosis of
dilated cardiomyopathy in a Northern Han Chinese population . -
pubmed
BACKGROUND :
Galectin-3 plays an important role in modulating
cardiac inflammation and
fibrosis . -
pubmed
Therefore ,
LGALS3 gene , encoding
galectin-3 protein , is a promising candidate for the genetic study of
dilated cardiomyopathy (
DCM ) . -
pubmed
To date , there has been no research evaluating the association between
LGALS3 gene polymorphisms and the susceptibility and prognosis of
DCM . -
pubmed
METHODS AND RESULTS : Genotyping of 4 single nucleotide polymorphisms ( SNPs ) in the
LGALS3 gene , which were reported to be functional in the literature , was performed in 279 unrelated clinically diagnosed
DCM patients and 363 apparently healthy controls from Northern Han Chinese population using iPLEX SNP Genotyping analysis on a Sequenom MassARRAY System . -
pubmed
The G variant of rs1009977 was related with lower serum
galectin-3 level in
DCM patients under three genetic models ( additive model , P=0.020 , dominant model , P=0.020 , recessive model , P=0.037 ) . -
pubmed
The A variant of both rs2274273 and rs4644 was associated with lower level of
galectin-3 in
DCM patients under additive model ( P=0.032 for both ) and dominant model ( P=0.012 for both ) . -
pubmed
In Conclusion ,
LGALS3 gene polymorphisms might be associated with the susceptibility of
DCM in a Northern Han Chinese population . -
pubmed
Caveolin-1 (
CAV1 ) is a scaffolding protein that modulates signaling pathways leading to remodeling of the
actin cytoskeleton and enhanced migration of
cancer cells . -
pubmed
Correction to :
Secondary antibody deficiency : a complication of anti -
CD20 therapy for
neuroinflammation . -
pubmed
PHOSPHO1 is essential for normal bone
fracture healing : An
Animal Study . -
pubmed
Methods : Tibial
fractures were created and then stabilized in control wild - type ( WT ) and
Phospho1-/-
mice ( n = 16 for each group ; mixed gender , each group carrying equal number of male and female
mice ) at eight weeks of age . -
pubmed
An
increase in trabecular number and a decrease in trabecular thickness and separation were observed in
Phospho1-/- callus in comparison with the WT callus . -
pubmed
Conclusion : Our work suggests that
PHOSPHO1 plays an integral role during bone
fracture repair and may be a therapeutic target to improve the
fracture healing process . -
pubmed
PHOSPHO1 is essential for normal bone
fracture healing : An
Animal Study . -
pubmed
Improvement and extension of anti -
EGFR targeting in
breast cancer therapy by integration with the Avidin - Nucleic - Acid - Nano - Assemblies . -
pubmed
Even if further studies are needed , we propose that NP tethering could expand application of the anti -
EGFR antibody to a wider number of
cancer patients including the
KRAS - mutated ones , currently suffering from poor prognosis . -
pubmed
Thus ,
resveratrol as a
hypoxia - inducible factor-1 - alpha inhibitor increased the radiosensitization of
breast cancer spheroid cells . -
pubmed
Determining the expression levels of
CD45 and
Foxp3 using immunohistochemistry facilitated the correct classification of
HCC patients and the prediction of their prognosis . -
pubmed
In 2018 , The Food and Drug Administration ( FDA ) of the US approved several novel agents for
AML treatment as follows :
ivosidenib , an inhibitor of
isocitrate dehydrogenase-1 ;
venetoclax , a potent inhibitor of
bcl2 ; and
glasdegib , an inhibitor of
hedgehog signaling pathway . -
pubmed
Duplication of
MECP2 - containing genomic segments causes
MECP2 duplication syndrome , a severe
neurodevelopmental disorder characterized by
intellectual disability ,
motor dysfunction , heightened
anxiety ,
epilepsy ,
autistic phenotypes , and
early death . -
pubmed
Here , we found that
MECP2 - TG
mice showed a significant
social recognition deficit , and were prone to display aversive - like behaviors , including heightened
anxiety - like behaviors and a fear generalization phenotype . -
pubmed
We used the CRISPR - Cas9 method to restore normal
MeCP2 levels in the medial prefrontal cortex ( mPFC ) and bed nuclei of the stria terminalis ( BST ) of adult
MECP2 - TG
mice , and found that normalization of
MeCP2 levels in the mPFC but not in the BST reversed the
social recognition deficit . -
pubmed
Thrombin generation assay modifications needed for its application to monitoring of replacement therapy for
haemophilia . -
pubmed
Major
depressive disorder (
MDD ) is associated with alterations of GABAergic interneurons , notably
somatostatin (
Sst ) as well as
parvalbumin (
Pvalb ) , in cortical brain areas . -
pubmed
Assessment of
Plasma Amyloid - beta42 / 40 and
Cognitive Decline Among Community - Dwelling Older Adults . -
pubmed
Importance : Plasma measurement of
amyloid - beta (
Abeta ) peptides has been associated with cognitive function , but evidence of its ability to identify
cognitive decline is still scarce . -
pubmed
After adjusting for age , sex , education , body mass index , Geriatric
Depression Scale score ,
apolipoprotein E epsilon4 genotype , and
MAPT intervention groups , low plasma
Abeta42 / 40 was associated with more pronounced decline in composite cognitive score ( adjusted between - group mean difference : -0.20 , 95 % CI , -0.34 to -0.07 ; P = .004 ) and decline in MMSE score ( adjusted between - group mean difference : -0.59 ; 95 % CI , -1.07 to -0.11 ; P = .02 ) during the follow - up period compared with the group with an
Abeta42 / 40 ratio greater than 0.107 . -
pubmed
Findings suggest that plasma
Abeta42 / 40 may be used to identify
people at risk of
cognitive decline , being an alternative to more complex and expensive measures , such as positron emission tomography imaging or cerebrospinal fluid measurement . -
pubmed
Secretin ( 1 CU / Kg ) plus
Caerulein ( 100 ng / Kg ) or
Cholecystokinin ( 1 or 2 IvyU / Kg ) were given by rapid intravenous injection ( Schedule 1 ) or by continuous infusion ( Schedule 2 ) to 63 control subjects ( C ) and 69
patients affected by
chronic pancreatitis (
CP ) . -
pubmed
HL - A antigens , autoantibody production , and associated diseases in
thymoma patients , with and without
myasthenia gravis . -
pubmed
Histocompatibility (
HL - A ) antigens were tested in 24
thymoma ( + )
MG ( + ) , 23
thymoma ( + )
MG ( - ) , and 43
thymoma ( - )
MG ( + )
patients and 533 controls from the Dutch population . -
pubmed
The frequencies of
HL - A8 were significantly decreased in both
thymoma groups that had a relatively high incidence of associated
immunological disorders ( Table 5 ) . -
pubmed
Oxidized
alpha 1 - proteinase inhibitor may thus be considered as a physiological inhibitor of
human pancreatic elastase which may prevent degradation of blood vessel
elastin during
acute hemorrhagic pancreatis . -
pubmed
Previous studies have demonstrated the importance of antibodies in mediating immunity to
malaria , but the relative contribution of the different
immunoglobulin isotypes has not been assessed . -
pubmed
Only
mice receiving
IgG2a antibodies experienced an altered course of
infection . -
pubmed
HLA antigens were studied in 121
patients with
dissemination sclerosis and 50
patients with
retrobulbar neuritis . -
pubmed
Effects of
neurotropin in
patients with
hereditary spino - cerebellar degeneration . -
pubmed
Rather than promoting tumorigenesis in vasopressinergic cells of the hypothalamus , expression and activity of the hybrid oncogene , and consequent
tumor formation , were confined to
insulin - producing beta cells of the endocrine pancreas and to cells in the anterior pituitary . -
pubmed
These actions can be of importance in normal physiological situations as well as in abnormal conditions where
IGF - I is decreased , such as
hypopituitarism and
malnutrition . -
pubmed
The rare , but not zero , associations of beta A with the 13 kb linkage and of
beta s genes with the 7.6 kb fragment would lessen the accuracy in the prenatal diagnosis of
sickle cell anaemia in this population through the use of the HpaI polymorphism . -
pubmed
The
48 - 1 antibody reacted with liver biopsy specimens from 12
chimpanzees obtained during the acute or chronic phase of
hepatitis caused by five different
NANB strains , but not with biopsy specimens from
chimpanzees with
hepatitis A or B or from normal
chimpanzees . -
pubmed
The risk of
respiratory disease did not show significant correlation with- and
globulin levels and with serum protein and
IgG1 levels at the time of purchase . -
pubmed
Hemoglobin Indianapolis was first described by Adams et al ( 1,2 ) as a very unstable variant with a phenotype similar to severe
beta - thalassemia . -
pubmed
Growth hormone in
Turner syndrome . -
pubmed
Steroid receptors in
tumors of nerve sheath origin . -
pubmed
To investigate the relationship between elevated adipose tissue
lipoprotein lipase (
LPL ) activity and
triglyceride uptake in Zucker
obese rats , fed and 12 hour fasted female
obese and lean Zucker
rats were given intrajugular infusion of radio - labelled
triglyceride and label clearance and uptake were examined over 35 minutes . -
pubmed
Regardless of feeding condition ,
obese rats exhibited elevations in adipose tissue
LPL , which was significantly correlated with label uptake in adipose tissue . -
pubmed
These results show that , in Zucker
obese rats , elevated adipose tissue
LPL is associated with increased adipose tissue
triglyceride uptake . -
pubmed
A preferential " shunting of calories " into adipose tissue , which is presumably mediated by
LPL , could underlie the intractability of the
Zucker obesity syndrome as well as the altered feeding behavior of Zucker
obese rats . -
pubmed
luteal insufficiency " is characterized by a very low concentration of
estradiol receptor . -
pubmed
The dextran - coated
charcoal assay method of McGuire and DeLaGarza is a well - known method for quantitation of
oestrogen receptors in
breast tumour tissues . -
pubmed
In this report we compare the results obtained using both methods to quantitate
oestrogen receptors and determine the affinity for
steroid binding in seven
human breast tumours and the uteri of
rat and calf . -
pubmed
To assess the efficacy and time - dependent effects of once - daily
moexipril , a
nonsulfhydryl ester prodrug of the
angiotensin - converting enzyme (
ACE ) inhibitor ,
moexiprilat , we conducted a multicenter , double - blind , placebo - controlled trial in 51
hypertensive patients using both clinic and ambulatory blood pressure ( BP ) recordings . -
pubmed
Previous studies demonstrated that stimulation of
type B gamma - aminobutyric acid ( GABAB ) receptors but not
type A ( GABAA ) receptors in the nucleus tractus solitarius of spontaneously
hypertensive rats elicited a larger increase in arterial pressure compared with control
rats of the Wistar - Kyoto strain . -
pubmed
The present studies extended that observation by examining the cardiovascular response to injection into the nucleus tractus solitarius of a selective
GABAB receptor antagonist ,
CGP 35348 , in these strains as well as examining the cardiovascular responses to stimulation or blockade of
GABAB receptors in the nucleus tractus solitarius in another model of
hypertension , the
rat treated with
deoxycorticosterone acetate and salt . -
pubmed
Similarly , in both models of
hypertension , the depressor response elicited by blockade of
GABAB receptors in the nucleus tractus solitarius by injection of
CGP 35348 was approximately 75 % greater compared with control
rats ( P & lt ; .05 in each model ) . -
pubmed
Failure of a protective
major histocompatibility complex class II molecule to delete autoreactive T cells in
autoimmune diabetes . -
pubmed
We show that neither thymic deletion nor anergy of autoreactive T cells occurs in
NOD mice transgenic for
I - Ak. -
pubmed
Supravalvular aortic stenosis associated with a deletion disrupting the
elastin gene . -
pubmed
In recent studies we presented evidence suggesting that a translocation disrupting the
elastin gene caused
SVAS in one family while deletions involving the entire
elastin locus caused
WS . -
pubmed
In this study , pulsed - field , PCR , and Southern analyses showed that a 100 - kb deletion of the 3 ' end of the
elastin gene cosegregated with the disease in another
SVAS family . -
pubmed
DNA sequence analysis localized the breakpoint between
elastin exons 27 and 28 , the same region disrupted by the
SVAS - associated translocation . -
pubmed
These data indicate that mutations in the
elastin gene cause
SVAS and suggest that
elastin exons 28 - 36 may encode critical domains for vascular development . -
pubmed
Recently it has been demonstrated that the
cytokines granulocyte - macrophage colony - stimulating factor (
GM - CSF ) ,
interleukin-3 (
IL-3 ) , and
interleukin-5 (
IL-5 ) are present in the circulation of
individuals with
allergic asthma . -
pubmed
Here the effect of
nedocromil sodium on the chemotactic response of eosinophils from
allergic asthmatic individuals and from normal donors preincubated with
GM - CSF or
IL-3 toward FMLP , NAF /
IL-8 was evaluated . -
pubmed
Dimeric
inhibin A as a marker for
Down ' s syndrome in early pregnancy . -
pubmed
BACKGROUND : In screening for
Down ' s syndrome in the second trimester of pregnancy , the concentrations of
alpha - fetoprotein , the
beta subunit of human chorionic gonadotropin , and intact
human chorionic gonadotropin in material serum are widely used markers . -
pubmed
Individual serum concentrations of each marker were converted to multiples of the median value at the appropriate length of gestation in the
women with normal pregnancies , and rates of detection of
Down ' s syndrome by screening for
inhibin A in various combinations with the other markers were estimated by multivariate analysis . -
pubmed
RESULTS : In the women with fetuses affected by
Down ' s syndrome , the serum
inhibin A concentrations were 2.06 times the median value in the
women with normal pregnancies ( P & lt ; 0.001 ) . -
pubmed
The serum concentrations of
inhibin A in the
women with fetuses affected by
Down ' s syndrome did not appear to be significantly elevated above normal until the end of the first trimester and were not significantly different from normal in the women with fetuses affected by
trisomy 18 ( P = 0.17 ) . -
pubmed
The rate of detection of
Down ' s syndrome was 53 percent and the false positive rate was 5 percent when
alpha - fetoprotein , the beta subunit of
human chorionic gonadotropin , the maternal age were used together as predictors . -
pubmed
CONCLUSIONS : In the second trimester of pregnancy , measuring
inhibin A in maternal serum , in combination with measurements of
alpha - fetoprotein and
beta subunit of human chorionic gonadotropin , significantly improved the rate of detection of
Down ' s syndrome . -
pubmed
The spectrum of
anemias treated with
recombinant human erythropoietin is rapidly broadening . -
pubmed
Receptor for
interleukin ( IL ) 13 does not interact with
IL4 but receptor for
IL4 interacts with
IL13 on
human glioma cells . -
pubmed
Recently , we have demonstrated that
human ( h )
glioma cell lines express large number of receptors (
R ) for interleukin 13 ( IL13 ) ( Debinski , W. , Obiri , N. I. , Powers , S. K. , Pastan , I. , and Puri , R. K. ( 1995 ) Clin . -
pubmed
Glucocorticoid regulation of hepatic
TNF production following cecal ligation and puncture
sepsis . -
pubmed
Many of the harmful effects evident during
sepsis are ascribed to excessive endogenous
TNF production . -
pubmed
Because the liver is an important source of circulating
TNF during
endotoxicosis , and because glucocorticoids are believed to have a regulatory role in suppressing endogenous
TNF production , we evaluated the effect of adrenalectomy on the hepatic production of
TNF in an isolated perfused liver model after cecal ligation and puncture ( CLP )
sepsis . -
pubmed
Thus , adrenalectomy increased circulating
TNF and hepatic
TNF production as well as mortality in CLP
sepsis . -
pubmed
These findings suggest an important role for endogenous glucocorticoids in modulating hepatic
TNF production during CLP - induced
sepsis . -
pubmed
[ Intraoperative
serum parathyroid hormone measurement in the surgical treatment of
hyperparathyroidism ] . -
pubmed
BACKGROUND :
PTH(1 - 84 ) short half life permits us to monitor parathyroidectomy efficacy , confirming complete resection after unilateral surgical approach in some cases of
primary hyperparathyroidism . -
pubmed
PATIENTS AND METHODS : In 18 consecutive
patients operated on for primary or secondary
hyperparathyroidism , serum
PTH(1 - 84 ) concentrations were assessed at different times before , during and after partial ( in 11
patients with
multiglandular illness ) and total resections . -
pubmed
Such MSI has been found to be associated with
hereditary nonpolyposis colorectal cancer (
HNPCC ) that involves mutation of the human mismatch repair genes
hMSH2 and
hMLH1 as well as many sporadic
cancers of most tissue types . -
pubmed
Fourteen of the 15
high MSI tumors had lost either
hMSH2 ( n = 8) or
hMLH1 ( n = 6 ) protein expression . -
pubmed
In contrast , all of the
low MSI tumors and the
MSI - negative tumors displayed normal expression of
hMSH2 and
hMLH1 . -
pubmed
The authors report on the
interferons and evolving therapies for
chronic viral hepatitis and conclude with a discussion of liver transplantation . -
pubmed
There were no significant differences in
cytokine production among the various groups , except for a decrease in
tumor necrosis factor production in malnourished
cancer patients , which was restored by
omega-3 fatty acids . -
pubmed
Examining the clinical findings in the mono group ( those with monoclonal
IgM alone ) and the poly group ( those with polyclonal
IgM alone or polyclonal and monoclonal
IgM ) we found clearly significant differences : more severe
liver involvement in the poly group , and higher cryocrit and
creatinine values , lower
C4 level and more severe
purpura in the mono group . -
pubmed
PML / RARalpha is the
leukemogenetic protein of
acute promyelocytic leukemia (
APL ) . -
pubmed
We studied the antitumor activity and
toxicity of
ZD1694 (
tomudex ) , a specific inhibitor of
thymidylate synthase (
TS ) , in
nude mice bearing
human head and neck squamous cell carcinoma A253 and
FaDu xenografts . -
pubmed
High plasma
thymidine in
mouse relative to
human ( approximately 1.3 microM and & lt;0.1 microM , respectively ) may complicate the study of antitumor activity and
toxicity of
TS inhibitors with
human tumor xenografts grown in the
mouse . -
pubmed
However ,
rodent models , particularly
human tumor xenografts , are still useful models for evaluation of antitumor activity and schedule selection for
TS inhibitors . -
pubmed
In the presence of the
beta ( 2 )- adrenoceptor antagonist ,
ICI 118551 , a hindquarters vasoconstrictor response to
human leptin was not seen , and there was a
tachycardia , as there was to
murine leptin . -
pubmed
Human kallikrein 6 as a biomarker of
alzheimer ' s disease . -
pubmed
A few biomarkers , including
tau protein and
amyloid beta-42 , are now used as aids for diagnosis and monitoring of
AD . -
pubmed
Our aim was to examine the possible use of cerebrospinal fluid , blood and tissue , and
human kallikrein 6 (
hK6 ) concentration as a marker of
AD . -
pubmed
We measured
hK6 in tissue extracts from
AD brain or normal
individuals , in cerebrospinal fluids of
AD patients or normals and in whole blood of
AD patients and normals and compared the findings . -
pubmed
RESULTS : We found that
hK6 concentration is tissue extracts from
AD brain were approximately twofold lower than extracts from normal controls . -
pubmed
We have also found that the whole blood
hK6 concentration in
AD patients is about ten times higher than
hK6 concentration in normal controls ( p = 0.002 ) . -
pubmed
CONCLUSIONS : This is the first report describing significant elevations of cerebrospinal fluid and plasma and whole blood
hK6 concentration in
AD patients , in comparison to controls . -
pubmed
These data suggest that
hK6 may constitute a new biomarker for diagnosis and monitoring of
AD . -
pubmed
The
reverse transcriptase enzyme
telomerase is responsible for maintaining telomeric DNA length in over 85 % of
cancer cells by catalyzing the synthesis of further telomeric repeats . -
pubmed
The myocardial adaptation to
atrial fibrillation , the so - called "
atrial remodeling " , includes shortening of the atrial refractory period , slowing of atrial conduction , shortening of the atrial action potential , a progressive reduction of
L - type calcium channel expression and
microfibrosis of the myocardial tissue . -
pubmed
Exclusion of linkage of nine
neuronal nicotinic acetylcholine receptor subunit genes expressed in brain in
autosomal dominant nocturnal frontal lobe epilepsy in four unrelated families . -
pubmed
Members of the ligand - gated
neuronal nicotinic acetylcholine receptor ( nAChR ) gene family (
CHRNA4 and
CHRNB2 , coding for the alpha4 and beta2 subunits , respectively ) are involved in
autosomal dominant nocturnal frontal lobe epilepsy (
ADNFLE ) . -
pubmed
However ,
ADNFLE is genetically heterogeneous and mutations in
CHRNA4 and
CHRNB2 account for only a minority of
ADNFLE cases . -
pubmed
Additional
nAChR subunits expressed in the brain are candidates for this
epilepsy . -
pubmed
The involvement of all genes coding for brain - expressed
nAChR subunits , with known chromosome localization (
CHRNB2 , 1q21 ;
CHRNA2 , 8p21 ;
CHRNA6 ,
CHRNB3 , 8p11.2 ;
CHRNA7 , 15q14 ;
CHRNA5 /
A3 / B4 , 15q24 and
CHRNA4 , 20q13.2 ) was investigated in four unrelated
ADNFLE Italian families for at least three generations . -
pubmed
These findings support the hypothesis that genes different from those coding for
alpha2 - 7 and
beta2 - 4 neuronal nAChR subunits could be responsible for
ADNFLE . -
pubmed
The frequency of allele
TNF2 in
tuberculosis patients was significantly higher than in controls ( chi 2 = 11.69 , p = 0.001 ) , suggesting an association of this allele with higher risk of
pulmonary tuberculosis or a disturbed immune response . -
pubmed
Urinary sediment , quantitative
proteinuria ,
creatinine clearance , antinuclear antibodies (
ANA ) , complement , circulating immune complexes ( CIC ) and renal biopsies were evaluated in all of the
patients . -
pubmed
Furthermore , abnormal levels of
CIC ,
CH50 and
C3 associated with WHO class II suggest a moderate but ongoing activation of immune - mediated
renal injury mechanisms . -
pubmed
Recent anti - cytokine therapy for
inflammatory diseases including
rheumatoid arthritis aimed to inhibit the binding of
cytokines to targeted cells such as fibroblasts and condrocytes . -
pubmed
This paper will review the utilization of soluble receptors specific to inflammatory
cytokines which potentially stimulate fibroblasts to regulate biological events involved in the pathogenesis of
periodontal diseases . -
pubmed
SMAGP , a new small trans - membrane glycoprotein altered in
cancer . -
pubmed
Immunohistochemical data obtained using
human breast , colon and lung cancer samples sustain this hypothesis since they showed that , in both primary
tumours and metastases , reduced expression and/or cytoplasmic redistribution of
SMAGP is superimposable with low histological
tumour differentiation features , namely a lack of epithelial cell polarity and disorganized tissue phenotype . -
pubmed
Nonetheless , both
Src and
PP2A enzymes are critical targets of
E4orf4 that likely cooperate to trigger
E4orf4 - induced
tumor cell killing and whose relative contributions may vary in function of the cellular background . -
pubmed
OBJECTIVES :
Adiponectin has been implicated in the pathophysiology of
metabolic syndrome and
coronary artery disease in
humans . -
pubmed
Clinical effects of
Abeta immunization ( AN1792 ) in
patients with
AD in an interrupted trial . -
pubmed
CONCLUSION : Although interrupted , this trial provides an indication that
Abeta immunotherapy may be useful in
Alzheimer disease . -
pubmed
Value of
C reactive protein in the assessment of erosive
osteoarthritis of the hand . -
pubmed
OBJECTIVE : To investigate the value of
serum C reactive protein (
CRP ) as a marker of
erosive osteoarthritis (
EOA ) of the hand . -
pubmed
In all
patients ,
CRP correlated with
RS ( r(s ) = 0.43 , p<0.001 ) , and mainly with JC at clinical observation ( r(s ) = 0.72 , p<0.001 ) and at bone scintigraphy ( r(s ) = 0.47 , p<0.001 ) . -
pubmed
The correlation of
CRP with
RS and
JC was confirmed at clinical observation and at bone scintigraphy in the EOA subgroup , but only with JC at clinical observation in the non - EOA subgroup . -
pubmed
Severe chronic experimental
autoimmune uveitis (
EAU ) of the C57BL/6
mouse induced by adoptive transfer of
IRBP1 - 20 - specific T cells . -
pubmed
B10RIII and B10A
mouse are highly susceptible to
IRBP - induced
uveitis , whereas B6
mouse is less susceptible . -
pubmed
Compared with the RDR , the sensitivity and specificity to detect
vitamin A deficiency for each test was , respectively : serum
retinol , 90 % and 78 % ;
retinol - binding protein (
RBP ) , 40 % and 91 % ;
retinol / RBP molar ratio , 60 % and 74 % ; conjunctival impression cytology , 44 % and 48 % ; slit - lamp examination , 20 % and 66 % ; tear film break - up time , 40 % and 69 % ; and Schirmer 's test , 20 % and 78 % . -
pubmed
Because
TLR7 agonists can impede
HCV infection both via
type I IFN and independently of
IFN , they may be considered as an alternative treatment of chronic
HCV infection , especially in
IFN - alpha - resistant
patients . -
pubmed
The emerging use of
TNF - alpha inhibitors in
orbital inflammatory disease . -
pubmed
Changes in hepatic immunoregulatory
cytokines in
patients with metastatic
colorectal carcinoma : implications for hepatic anti - tumour immunity . -
pubmed
This study examines the
cytokine milieu of normal and
tumour - bearing liver , quantifying pro-/anti - inflammatory
cytokines using modified ELISAs and real - time quantitative PCR . -
pubmed
Inflammatory
IFN - gamma was increased in
tumour - bearing liver ( p<0.0001 ) . -
pubmed
However , a much greater increase in anti - inflammatory
IL-10 , produced by non - parenchymal cells ( p<0.0005 ) , resulted in a reduced
IFN - gamma :
IL-10 ratio in
tumour - bearing liver ( p<0.02 ) . -
pubmed
The
IFN - gamma inducing cytokine ,
IL-18 was increased in
tumour - bearing liver ( p<0.02 ) , while pro - inflammatory
TNF - alpha was suppressed ( p<0.05 ) . -
pubmed
These results suggest that , whilst there is a significant inflammatory immune response in tumour - bearing liver , evidenced by increased levels of
IFN - gamma , disproportionate increase in
IL-10 may be a key factor in facilitating
tumour progression . -
pubmed
GM - CSF autoantibodies and
neutrophil dysfunction in
pulmonary alveolar proteinosis . -
pubmed
BACKGROUND : Increased mortality from
infection in
patients with
pulmonary alveolar proteinosis occurs in association with high levels of autoantibodies against
granulocyte - macrophage colony - stimulating factor (
GM - CSF ) . -
pubmed
We tested the hypothesis that neutrophil functions are impaired in
patients with
pulmonary alveolar proteinosis and that
GM - CSF autoantibodies cause the dysfunction . -
pubmed
RESULTS : Neutrophils from
subjects with
pulmonary alveolar proteinosis had normal ultrastructure and differentiation markers but impaired basal functions and antimicrobial functions after
GM - CSF priming . -
pubmed
The
neutrophil dysfunction characteristic of
pulmonary alveolar proteinosis was reproduced in a dose - dependent fashion in blood specimens from healthy control subjects after incubation with affinity - purified
GM - CSF autoantibodies isolated from
patients with
pulmonary alveolar proteinosis . -
pubmed
The injection of
mouse GM - CSF antibodies into wild - type
mice also caused
neutrophil dysfunction . -
pubmed
CONCLUSIONS : The antimicrobial functions of neutrophils are impaired in
patients with
pulmonary alveolar proteinosis , owing to the presence of
GM - CSF autoantibodies . -
pubmed
Genetic and epigenetic regulation of the
human prostacyclin synthase promoter in
lung cancer cell lines . -
pubmed
In
human lung cancer ,
prostacyclin synthase (
PGIS ) and
PGI2 are down - regulated , whereas
PGE2 synthase (
PGES ) and
PGE2 are up - regulated . -
pubmed
Murine carcinogenesis models of
human lung cancer reciprocate the relationship between
PGIS and
PGES expression . -
pubmed
PGIS - overexpressing
transgenic mice are protected from carcinogen- and
tobacco smoke - induced
lung tumor formation , suggesting that
PGI2 may play a role in chemoprevention . -
pubmed
We investigated several potential mechanisms for the down - regulation of
PGIS in
human lung cancer . -
pubmed
In addition ,
PGIS expression in several
human lung cancer cell lines is silenced by
CpG methylation , and we have mapped these sites across the variable number of tandem repeats ( VNTR ) sequence in the promoter , as well as CpGs within exon 1 and the first intron . -
pubmed
Finally , using fluorescence in situ hybridization , we show that
human lung cancer cell lines and
lung cancer tissues do not have a loss of the
PGIS genomic region but multiple copies . -
pubmed
These results show that an individual 's
PGIS promoter haplotype can play an important role in the predisposition for
lung cancer and
CpG methylation provides an epigenetic mechanism for the down - regulated
PGIS expression . -
pubmed
Involvement and consequences of the proteasomal degradation machinery in the
HBc protein turnover during
HBV infection with complex
HBV variants in the immunosuppressed patients are discussed . -
pubmed
ARF occurred in 24
patients ; they tended to be older and
hypertensive with lower
serum albumin and more
proteinuria than those without
ARF . -
pubmed
The
ATP - binding cassette transporter subfamily A member 1 (
ABC - A1 ) and
type 2 diabetes : an association beyond HDL
cholesterol . -
pubmed
Recent findings from several groups demonstrate that
ABC - A1 participates in the pathogenesis of the
metabolic syndrome and type 2 diabetes . -
pubmed
A variant of the
ABC - A1 gene ( R230C ) is associated with the
metabolic syndrome and its co - morbidities in Mexicans . -
pubmed
Moreover ,
animal models confirm the participation of
ABC - A1 in the pathogenesis of
diabetes . -
pubmed
Mice lacking
AbcA1 specifically in beta cells had
glucose intolerance at 8 weeks of age . -
pubmed
Reduced
CD4+T cell activation in
children with
type 1 diabetes carrying the
PTPN22 /
Lyp 620Trp variant . -
pubmed
The 620Trp variant of the
LYP protein , encoded by the
lymphoid tyrosine phosphatase 22 gene (
PTPN22 ) , is associated with
autoimmunity . -
pubmed
We analysed
cytokine secretion and proliferation of peripheral blood mononuclear cells ( PBMCs ) and
CD4(+)T cells in a cohort of clinically non - diabetic , multiple autoantibody - positive
children , healthy controls and in
children with
type 1 diabetes (
T1D ) . -
pubmed
We found a decreased proliferation and
IL-2 production of
CD4(+)T cells after
anti - CD3 /
anti - CD28 stimulation ( p=0.04 for
IL-2 ) among
T1D patients . -
pubmed
In contrast , no effect of this polymorphism on
tuberculin and tetanus toxoid induced PBMC proliferation and
cytokine secretion was observed in autoantibody positive children , healthy controls and children with newly - diagnosed
T1D. -
pubmed
In conclusion , the LYP 620Trp variant is associated with reduced activation , proliferation and
IL-2 production in
CD4(+)T cells among
T1D patients . -
pubmed
The incidence of in - hospital mortality ( 0 % vs. 0.3 % p = 1.000 ) ,
MI ( 7.1 % vs. 6.6 % ; p = 0.864 ) , and the combined endpoint of death ,
stroke , emergent coronary artery bypass graft surgery ( CABG)/PCI , or
MI ( 7.1 % vs. 6.9 % ; p = 0.868 ) were similar in the bivalirudin - plus - bailout
GP IIb / IIIa inhibitor versus the
bivalirudin - alone arm . -
pubmed
These data suggest that a strategy of bivalirudin monotherapy is preferable in order to reduce
bleeding complications , and
GP IIb / IIIa blockade should be reserved for
patients with periprocedural complications in
bivalirudin - treated
patients undergoing PCI . -
pubmed
Furthermore , we found that the C57BL/6J - like changes in
anxiety - related behavior after restraint were absent in null mutants lacking the modulatory
NMDA receptor subunit
Grin2a , but not the
AMPA receptor subunit
Gria1 . -
pubmed
Association of
insulin sensitivity to lipids across the lifespan in people with
Type 1 diabetes . -
pubmed
RESULTS : Lower
glucose infusion rate was significantly associated with lower levels of
HDL cholesterol in youths with
Type 1 diabetes and with higher levels of
triglycerides and higher
triglyceride / HDL ratio in both youths and adults . -
pubmed
CONCLUSIONS : Lower
insulin sensitivity is associated with a more atherogenic lipid profile in both youths and adults with
Type 1 diabetes . -
pubmed
Low
serum myeloperoxidase in autistic
children with
gastrointestinal disease . -
pubmed
AIM : To assess
serum myeloperoxidase (
MPO ) levels in autistic
children with severe
gastrointestinal ( GI ) disease and to test the hypothesis that there is an association between serum
MPO concentration and
inflammatory GI disease , including
antineutrophil cytoplasmic antibodies ( ANCA ) , previously seen in a subgroup of autistic
children . -
pubmed
SUBJECTS AND METHODS : Serum from 40 autistic
children with
chronic digestive disease ( most with
ileo - colonic lymphoid nodular hyperplasia (
LNH ) and
inflammation of the colorectum , small bowel and/or stomach ) , and 48 controls ( 12 age - matched autistic
children with no
GI disease , 20 age - matched
children without
autism or
GI disease , and 16 nonautistic
individuals with no family history of
autism ) were tested using enzyme - linked immunosorbent assays designed to quantitate serum
MPO levels . -
pubmed
MPO serum concentration of autistic
children with
GI disease was compared to
GI disease severity ( including LNH and
erythema ) and presence of ANCA . -
pubmed
RESULTS : We found that a significant number of autistic
children with
chronic digestive disease had low serum levels of
MPO . -
pubmed
DISCUSSION : These results suggest a relationship between low
MPO levels and
GI disease seen in a subpopulation of
autism spectrum disorders individuals . -
pubmed
MPO concentration may therefore be a useful biomarker for
GI disease in this group of autistic
children . -
pubmed
In this study , we treated infected CBA
mice with
cromolyn , an MC stabilizer , and observed much greater
parasitemia and
interferon - gamma levels , higher mortality ,
myocarditis , and
cardiac damage . -
pubmed
Using RT - PCR in purified cardiac MCs , we observed that
infection induced transcription of
P2X ( 7 ) receptor and
Fas , two molecules reportedly involved in cell death and inflammatory regulation . -
pubmed
Conversely ,
infection of
P2X ( 7 )(-/- ) mice led to reduced peritoneal , but not cardiac , MC death . -
pubmed
Progression of
tau pathology in cholinergic Basal forebrain neurons in
mild cognitive impairment and
Alzheimer ' s disease . -
pubmed
Tau is a microtubule - associated protein that forms neurofibrillary tangles ( NFTs ) in the selective vulnerable long projection neurons of the cholinergic basal forebrain ( CBF ) in
Alzheimer ' s disease (
AD ) . -
pubmed
Although CBF neurodegeneration correlates with cognitive decline during
AD progression , little is known about the temporal changes of
tau accumulation in this region . -
pubmed
We investigated
tau posttranslational modifications during NFT evolution within the CBF neurons of the nucleus basalis ( NB ) using tissue from
subjects with no
cognitive impairment ,
mild cognitive impairment , and
AD . -
pubmed
We also investigated the occurrence of pretangle tau events within cholinergic NB neurons by dual staining for the cholinergic cell marker ,
p75 ( NTR ) , which displays a phenotypic down - regulation within CBF perikarya in
AD . -
pubmed
As pS422 + neurons increased in number ,
p75 ( NTR )+ neurons decreased , and these changes correlated with both
AD neuropathology and
cognitive decline . -
pubmed
Methylation status of
CpG sites in the MCP-1 promoter is correlated to serum
MCP-1 in
Type 2 diabetes . -
pubmed
AIM :
Monocyte chemoattractant protein-1 (
MCP-1 ) is a potent
chemokine and plays an important role in
atherosclerosis of Type 2 diabetes . -
pubmed
The aim of this study was to investigate the methylation status of
CpG sites in the MCP-1 promoter in
Type 2 diabetic patients and its correlation to serum
MCP - 1 level , and blood
glucose level . -
pubmed
Methylation of CpGmotifs were less methylated in the
patients than in the controls ( 25 % vs 80 % ; p<0.001 ) , while the level of
MCP-1 in serum was higher in patients with
Type 2 diabetes ( 193.95 + -74.96 vs 88.46 + -55.10 ; p<0.001 ) . -
pubmed
CONCLUSION : These data suggest that hypomethylation of
CpG sites in the MCP-1 promoter region may be affected by blood
glucose and TG , which then increase the serum
MCP-1 level and may play a role in the vascular complications of
Type 2 diabetes . -
pubmed
Six of these proteins (
uromodulin ,
alpha-1 - microglobulin ,
zinc - alpha-2 - glycoprotein ,
cystatin C ,
Ig - kappa - chain , and
inter - alpha - trypsin heavy chain H4 ) were strongly correlated with various forms of
kidney disorders . -
pubmed
Pilot study of the clinical significance of serum and urinary
her-2 / neu protein in
bladder cancer patients . -
pubmed
PURPOSE :
HER-2 / neu overexpression is documented in some
bladder cancers . -
pubmed
Therefore , we examined the clinical significance of serum and urine
HER-2 / neu protein in
bladder cancer . -
pubmed
Urine cytology and serum and urine
HER-2 / neu levels were measured before the transurethral resection of
bladder tumor procedure . -
pubmed
Prognostic factors including
tumor stage , histologic grade ,
tumor size , multiplicity , and preoperative urine cytology and their association with urinary
HER-2 / neu were analyzed by simple and multiple regression analyses . -
pubmed
The mean urinary
HER-2 / neu was 7,586.82 relative luminescence unit ( RLU ) in
bladder cancer patients and 4,245.84 RLU in healthy controls . -
pubmed
The mean RLU values of urinary
HER-2 / neu in the
bladder cancer patient group were significantly higher than in healthy controls ( p=0.012 ) . -
pubmed
CONCLUSIONS :
Bladder cancer patients demonstrated significantly higher urinary
HER-2 / neu than did healthy controls . -
pubmed
For example , defects in the clearance of self - antigens and chronic stimulation of
type 1 interferons lead to the systemic autoimmunity seen in
C1q deficiency ,
SPENCDI , and
AGS . -
pubmed
Using these SNPs no evidence for causality between the
fibrinogen levels and
coronary heart diseases was found in instrumental variables analysis . -
pubmed
[ Role of
PDGF - A /
PDGFR - alpha in proliferation and transdifferentiation of fibroblasts from
skin lesions of
patients with
systemic sclerosis ] . -
pubmed
OBJECTIVE : To study the role of
platelet - derived growth factor A (
PDGF - A)/
PDGF receptor - alpha (
PDGFR - alpha ) signaling pathway in the proliferation and transdifferentiation of fibroblasts ( FB ) into myofibroblasts ( MFB ) in the skin lesions of
patients with
systemic sclerosis (
SSc ) . -
pubmed
METHODS : The primary FBs isolated from the skin lesions of
SSc patients and normal adult skin cultured in vitro were examined for
alpha - smooth muscle actin (
alpha - SMA ) using immunocytochemistry . -
pubmed
Below the saturated concentration of
PDGF , the FBs in the two groups both proliferated in a dose - dependent manner ( P<0.05 ) , but the FBs from the
SSc lesions always showed a significantly higher proliferative activity ( P<0.05 ) . -
pubmed
PDGF - AA and
TGF - beta ( 1 ) , alone or in combination , up - regulated the expression level of PDGFR - alpha and alpha - SMA mRNA in the FBs from
SSc lesions ; similar results were obtained in the control FBs , except that
TGF - beta ( 1 ) alone did not influence PDGFR - alpha mRNA expression . -
pubmed
Over - expression of
PDGFR - alpha on the surface of FBs from
SSc lesions can bind more
PDGF - AA ligands to increase cell proliferation and promote transdifferentiation to MFB , and
TGF - beta ( 1 ) further enhances this effect . -
pubmed
However , it is currently unknown how
BAG-1 expression is regulated at the molecular level , especially in
cancer cells . -
pubmed
Furthermore , enhanced
FLJ20420 expression was observed in
tumor cell lines ( i.e. -
pubmed
Finally , our gene array studies in
lung cancer tissue samples revealed a significant increase in
FLJ20420 expression in primary
lung cancer relative to the paired
normal lung tissue controls ( p = 0.0006 ) . -
pubmed
The increased expression of FLJ20420 corresponded to a significant decrease in
BAG-1 protein expression in the primary
lung cancers , relative to the paired
normal lung tissue controls ( p = 0.0001 ) . -
pubmed
Selective blockers of the
N - type calcium channel have proven to be effective in
animal models of
chronic pain . -
pubmed
Therefore , the identification of orally active , small - molecule
N - type calcium channel blockers would represent a significant advancement in the treatment of
chronic pain . -
pubmed
Tumor suppressive miR-124 targets
androgen receptor and inhibits proliferation of
prostate cancer cells . -
pubmed
Increased serum
osteoprotegerin in
patients with
primary adrenal insufficiency receiving conventional
hydrocortisone substitution . -
pubmed
The study was aimed to investigate the effect of
steroid substitution on serum
osteoprotegerin and
receptor activator of nuclear factor kappa - beta ligand (
RANKL ) levels in relation to bone mineral density ( BMD ) in
PAI . -
pubmed
Mean
osteoprotegerin concentration in
PAI patients appeared significantly higher vs. controls ( p=0.002 ) , while
RANKL levels were similar ( p=0.430 ) . -
pubmed
Patients with
osteoporosis displayed higher
osteoprotegerin levels , but after the age - adjustment the correlation was lost . -
pubmed
In conclusion , increased
osteoprotegerin in
PAI might reflect a compensatory response to enhanced bone resorption due to exogenous
steroid excess and/or result from a deficit in adrenal
androgens . -
pubmed
Association between reduction of plasma
adiponectin levels and risk of
bacterial infection after
gastric cancer surgery . -
pubmed
ROC analysis revealed that the useful cutoff values ( sensitivity / specificity ) for preoperative ADN levels , ADN ratio ,
blood loss , operating time , and
CRP levels were 8.81(0.567/0.568 ) , 0.76 ( 0.767/0.761 ) , 405 g ( 0.717/0.693 ) , 342 min ( 0.617/0.614 ) , and 8.94 mg / dl ( 0.583/0.591 ) , respectively . -
pubmed
Androgen receptor - independent function of
FoxA1 in
prostate cancer metastasis . -
pubmed
To date , there have been conflicting reports on the role of
FoxA1 in
prostate cancer progression and prognosis . -
pubmed
With recent discoveries of recurrent
FoxA1 mutations in
human prostate
tumors , comprehensive understanding of
FoxA1 function has become very important . -
pubmed
Using orthotopic
mouse models , we further show that
FoxA1 inhibits
prostate tumor metastasis in vivo . -
pubmed
Concordant with these contradictory effects on
tumor progression ,
FoxA1 expression is slightly upregulated in localized
prostate cancer wherein cell proliferation is the main feature , but is remarkably downregulated when the
disease progresses to metastatic stage for which cell motility and EMT are essential . -
pubmed
Taken together , our findings illustrate an
AR - independent function of
FoxA1 as a metastasis inhibitor and provide a mechanism by which recurrent
FoxA1 mutations contribute to
prostate cancer progression . -
pubmed
OBJECTIVE : The aims of this study were to develop carrageenan - induced
hyperalgesia in
rhesus monkeys and determine the efficacy and potency of agonists selective for the four
opioid receptor subtypes in this model versus acute
pain , as compared to non - steroidal anti - inflammatory drugs ( NSAIDs ) . -
pubmed
Only
fentanyl produced scratching at antihyperalgesic and antinociceptive doses consistent with its
pruritic effects in
humans , illustrating a translational profile of
MOP agonists in
nonhuman primates . -
pubmed
CONCLUSION : Using two different
pain modalities in
nonhuman primates , effectiveness of clinically available analgesics like
fentanyl ,
ketorolac and
naproxen was distinguished and their efficacies and potencies were compared with the selective
KOP ,
DOP , and
NOP agonists . -
pubmed
TFDP3 was expressed in coordination with
E2F1 to inhibit
E2F1 - mediated apoptosis in
prostate cancer . -
pubmed
TFDP3 expression was assessed by RT - PCR , in situ hybridization and immunohistochemistry in
normal human tissues ,
cancer tissues and
prostate cancer tissues . -
pubmed
The association between
TFDP3 and
E2F1 in
prostate cancer development was analyzed in various stages . -
pubmed
The results show that , in 96 samples of
normal human tissues ,
TFDP3 could be detected in the cerebrum , esophagus , stomach , small intestine , bronchus , breast , ovary , uterus , and skin , but seldom in the lung , muscles , prostate , and liver . -
pubmed
In addition ,
TFDP3 was highly expressed in numerous
cancer tissues , such as
brain - keratinous , lung squamous cell carcinoma ,
testicular seminoma ,
cervical carcinoma ,
skin squamous cell carcinoma ,
gastric adenocarcinoma ,
liver cancer , and
prostate cancer . -
pubmed
Moreover ,
TFDP3 was positive in 23 ( 62.2 % ) of 37
prostate cancer samples regardless of stage . -
pubmed
Furthermore , immunohistochemistry results show that
TFDP3 was always expressed in coordination with
E2F1 at equivalent expression levels in
prostate cancer tissues , and was highly expressed particularly in samples of high stage . -
pubmed
It was demonstrated that
TFDP3 was a broadly expressed protein corresponding to
E2F1 in
human tissues , and suggested that
TFDP3 is involved in
prostate cancer cell survival by suppressing apoptosis induced by
E2F1 . -
pubmed
The predictive value of
GSTT1 polymorphisms in predicting the early response to induction BCG therapy in
patients with
non - muscle invasive bladder cancer . -
pubmed
INTRODUCTION : We evaluated the predictive value of
glutathione S transferase mu (
GSTM1 ) and
theta (
GSTT1 ) polymorphisms in early response to bacillus Calmette - Guerin ( BCG ) induction therapy in
patients with primary
non - muscle invasive bladder cancer . -
pubmed
METHODS :
GSTM1 and
GSTT1 polymorphisms were analyzed by multiplex polymerase chain reaction using blood genomic DNA from 135
patients with primary
non - muscle invasive bladder cancer who were being treated with a single induction course of BCG . -
pubmed
After stratification based on the
tumor stage and grade , the high - risk group ( T1G3 ) with a
GSTT1 - positive genotype showed a 14 - fold higher risk of early
BCG failure compared with those with a
GSTT1 - null genotype . -
pubmed
By multivariate logistic regression analysis , the
GSTT1 - positive genotype was an independent predictor of early
BCG failure ( odds ratio = 3.67 , 95 % CI : 1.61 - 8.38 ) . -
pubmed
Kaplan - Meier estimates revealed a significant difference in
disease - free survival depending on the
GSTT1 genotype ( log rank test , P = 0.038 ) . -
pubmed
Here we show that the
aryl hydrocarbon receptor (
AhR ) , a
transcription factor that senses environmental stimuli , modulates pathology in
psoriasis . -
pubmed
AhR - activating ligands reduced
inflammation in the lesional skin of
psoriasis patients , whereas
AhR antagonists increased
inflammation . -
pubmed
Similarly ,
AhR signaling via the endogenous ligand
FICZ reduced the inflammatory response in the
imiquimod - induced model of
skin inflammation and
AhR - deficient
mice exhibited a substantial exacerbation of the disease , compared to
AhR - sufficient controls . -
pubmed
Thus , our data suggest a critical role for
AhR in the regulation of inflammatory responses and open the possibility for novel therapeutic strategies in
chronic inflammatory disorders . -
pubmed
Inhibition of
SGK1 enhances
mAR - induced apoptosis in
MCF-7 breast cancer cells . -
pubmed
Functional membrane
androgen receptors (
mAR ) have previously been described in
MCF-7 breast cancer cells . -
pubmed
Our results demonstrate that
mAR activation triggers pro - apoptotic responses in
breast tumor cells , an effect significantly enhanced by
SGK1 inhibition , involving
actin reorganization and paralleled by down - regulation of
FAK /
Akt signaling . -
pubmed
Serum
HDL level may be a potential candidate predictor for the future risk of
suicidality . -
pubmed
The mitotic kinesin
KIF11 is a driver of invasion , proliferation , and self - renewal in
glioblastoma . -
pubmed
Inhibition of
KIF11 with a highly specific small - molecule inhibitor stopped the growth of the more treatment - resistant
glioblastoma tumor - initiating cells ( TICs , or
cancer stem cells ) as well as non - TICs and impeded
tumor initiation and self - renewal of the
TIC population . -
pubmed
Targeting
KIF11 also hit the other arm of the " go or grow " cell fate decision by reducing
glioma cell invasion . -
pubmed
Administration of a
KIF11 inhibitor to
mice bearing
orthotopic glioblastoma prolonged their survival . -
pubmed
In its role as a shared molecular regulator of cell growth and motility across intratumoral heterogeneity ,
KIF11 is a compelling therapeutic target for
glioblastoma . -
pubmed
Univariable analysis revealed that male gender , presence of
anti - Scl 70 and absent anti - centromere antibody was significant predictors of
ILD . -
pubmed
Male gender , presence of
anti - Scl 70 , and absent anti - centromere antibody predicted the future development of
ILD in early -
SSc patients . -
pubmed
Two cases of early - onset
myoclonic seizures with continuous parietal delta activity caused by
EEF1A2 mutations . -
pubmed
BACKGROUND : Mutations in the
elongation factor 1 alpha 2 (
EEF1A2 ) gene have recently been shown to cause severe
intellectual disability with early - onset
epilepsy . -
pubmed
CONCLUSION : This report provides clinical data on
epileptic encephalopathy in
patients with
EEF1A2 mutation . -
pubmed
Impact Study :
MK-0646 ( Dalotuzumab ) ,
Insulin Growth Factor 1 Receptor Antibody Combined with
Pemetrexed and
Cisplatin in Stage IV Metastatic
Non - squamous Lung Cancer . -
pubmed
Adenocarcinoma and never - smokers have a higher expression of
IGF-1R , which is associated with worse overall survival . -
pubmed
Diabetes Caused by
Elastase - Cre - Mediated
Pdx1 Inactivation in
Mice . -
pubmed
Along with
exocrine defects , including impaired acinar cell maturation , the mutant
mice exhibited substantial
endocrine defects , including disturbed tip / trunk patterning of the developing ductal structure , a reduced number of
Ngn3 - expressing endocrine precursors , and ultimately fewer beta cells . -
pubmed
TOX expression and role in
CTCL . -
pubmed
MF /
CTCL have increased expression of
thymocyte selection - associated HMG box protein (
TOX ) . -
pubmed
Although
TOX has been proposed to be a diagnostic marker for
MF , further validation studies are needed . -
pubmed
Moreover , it is unclear what drives
TOX expression or its role in
MF /
CTCL . -
pubmed
OBJECTIVE : We hypothesize evaluation of
TOX levels across a spectrum of
CTCL , including
MF precursor ( large
plaque parapsoriasis ,
LPP ) , will help elucidate the implications of altered
TOX expression . -
pubmed
MATERIALS AND METHODS : TOX staining was performed in
MF ,
CD30(+ )
LPD ,
LPP as well as
benign inflammatory dermatoses (
BID ) and normal skin ( NS ) . -
pubmed
RESULTS : Positive
TOX expression was identified in 73.6 % of
MF cases and in 31.6 % of BID /
NS . -
pubmed
TOX expression in
MF was detected more commonly in Black patients ( P = 0.015 ) and less commonly in transformed
MF ( P = 0.045 ) . -
pubmed
In
CTCL cells ,
GATA3 knockdown decreased TOX mRNA and protein expression . -
pubmed
CONCLUSION : Our data indicate that
TOX is useful as a diagnostic marker in
MF . -
pubmed
Moreover ,
TOX expression was evident in LPP , indicating it may have a previously unappreciated role in the development of
MF . -
pubmed
Epidermal Growth Factor Receptor Mutation Enhances Expression of
Cadherin-5 in
Lung Cancer Cells . -
pubmed
Epidermal growth factor receptor (
EGFR ) activation has been shown to play a critical role in
tumor angiogenesis . -
pubmed
In this study , we investigate the correlation between
EGFR mutations and
cadherin-5 (
CDH5 ) , which is an angiogenic factor , in
lung cancer cells . -
pubmed
Increased expression
CDH5 is observed in
lung cancer cells with
EGFR mutations . -
pubmed
Stable
lung cancer cell lines expressing mutant ( exon 19 deletion E746 - A750 , and exon 21 missense mutation L858R ) and wild type
EGFR genes are established . -
pubmed
A significantly higher expression of
CDH5 is observed in exon 19 deletion stable
lung cancer cells and
mouse xenografts . -
pubmed
Further studies show that expression of
CDH5 is decreased after the inhibition of
EGFR and downstream
Akt pathways in
lung cancer cells with
EGFR mutation . -
pubmed
In addition , mutant
EGFR genes potentiates angiogenesis in lung cancer cells , which is inhibited by
CDH5 siRNA , and potentiates migration and invasion in
lung cancer cells . -
pubmed
Our result may provide an insight into the association of mutant
EGFR and
CDH5 expression in
lung cancer and aid further development of target therapy for
NSCLC in the future . -
pubmed
Transgenic knockout of either
claudin gene causes
hypotension ,
hypochloremia , and
metabolic alkalosis in experimental
animals . -
pubmed
Kelch - like 3 , previously identified as a causal gene for
Gordon ' s syndrome , also known as pseudohypoaldosteronism II , directly interacts with
claudin-8 and regulates its ubiquitination and degradation . -
pubmed
Deregulation of
claudins may cause
human hypertension as exemplified in the
Gordon ' s syndrome . -
pubmed
Five hours after the procedure , the whole cornea was excised and subjected to image analysis for
corneal edema , real - time semiquantitative PCR ( qPCR ) for
heme oxygenase ( HO )- 1 ,
catalase (
CAT ) ,
superoxide dismutase 1 (
SOD1 ) , and
SOD2 mRNA , and immunohistochemistry . -
pubmed
Corneal edema was significantly less and the increases in anti - oxidative
HO-1 ,
CAT and
SOD2 mRNA expressions were significantly suppressed in the
H2 group . -
pubmed
The
MET /
Vascular Endothelial Growth Factor Receptor (
VEGFR)-targeted
Tyrosine Kinase Inhibitor Also Attenuates
FMS - dependent Osteoclast Differentiation and Bone Destruction Induced by
Prostate Cancer . -
pubmed
The
tyrosine kinase inhibitor
TAS-115 that blocks
VEGF receptor and
hepatocyte growth factor receptor MET signaling exhibits antitumor properties in xenografts of
human gastric carcinoma . -
pubmed
Our study indicates that
tyrosine kinase signaling in host pre - osteoclasts / osteoclasts is critical for bone destruction induced by
tumor cells and that targeting of
MET /
VEGF receptor /
FMS activity makes it a promising therapeutic candidate for the treatment of
prostate cancer patients with bone metastasis . -
pubmed
Effects of an
alpha1A / D - adrenoceptor antagonist ,
naftopidil , and a
phosphodiesterase type 5 inhibitor ,
tadalafil , on urinary bladder remodeling in
rats with
spinal cord injury . -
pubmed
AIMS : In order to clarify whether an
alpha1A / D - adrenoceptor (
alpha1 A / D - AR ) antagonist ,
naftopidil , or a
phosphodiesterase type 5 (
PDE5 ) inhibitor ,
tadalafil , prevents bladder wall remodeling after
spinal cord injury (
SCI ) , we examined the bladder and urethral activity as well as ischemic and fibrotic changes in the bladder using
SCI rats with or without
naftopidil or
tadalafil treatment . -
pubmed
Bladder and urethral pressures , mRNA levels of
fibrosis - related molecules and
ischemia markers and the composition of bladder
collagen and
elastin were evaluated . -
pubmed
RESULTS :
Naftopidil treatment reduced the upregulation of mRNA levels of
ischemia and
fibrosis markers at the early phase of
SCI , and ameliorated the decrease of bladder compliance and voiding efficiency , and the increase of urethral pressure and
collagen concentration in the bladder wall at the late phase of
SCI . -
pubmed
Tadalafil treatment reduced the upregulation of mRNA levels of
fibrosis markers , the decrease of bladder compliance and the increase of
collagen concentration at the late phase of
SCI . -
pubmed
CONCLUSIONS : These results suggest that
naftopidil and
tadalafil treatments improved the bladder remodeling shown by increased bladder
collagen contents after
SCI in a different time course . -
pubmed
BACKGROUND :
Celecoxib is a selective
cyclo - oxygenase-2 inhibitor recommended orally to treat
arthritis and
osteoarthritis . -
pubmed
Association between
AXL , Hippo Transducers , and Survival Outcomes in
Male Breast Cancer . -
pubmed
We have previously reported that the expression of the Hippo transducers
TAZ /
YAP and their target
CTGF was associated with inferior survival in
MBC patients . -
pubmed
Thus , we herein assessed
AXL expression to further investigate the significance of active
TAZ /
YAP - driven transcription in
MBC . -
pubmed
Patients with
TAZ /
CTGF /
AXL- or
YAP /
CTGF /
AXL - expressing
tumors had inferior survival compared with non - triple - positive patients ( log rank P = 0.042 and P = 0.048 , respectively ) . -
pubmed
The expression pattern of
AXL corroborates the idea of the detrimental role of
TAZ /
YAP activation in
MBC . -
pubmed
Here , we determined the expression pattern of
FOXO in healthy and degenerated
human IVD and the associations with
IVD degeneration during
mouse aging . -
pubmed
Mouse spines were graded for key histological features of
disc degeneration in all the time points and expression of two key FOXO downstream targets ,
sestrin 3 (
SESN3 ) and
superoxide dismutase (
SOD2 ) , was assessed by immunohistochemistry . -
pubmed
The reduction of spontaneous epileptiform bursting in the CA3 is correlated to a reduction in
pilocarpine - induced
SE in vivo in
TRPC7 knockout
mice . -
pubmed
Although the
pilocarpine - induced
SE itself is not significantly reduced , the
SE - induced neuronal cell death is significantly reduced in the CA1 and the lateral septum , indicating that
TRPC1 / 4 channels directly contribute to
SE - induced neuronal cell death . -
pubmed
Genetic ablation of
TRPC5 also reduces
SE - induced neuronal cell death in the CA1 and CA3 areas of the hippocampus . -
pubmed
METHODS : In this study , we evaluated the inhibitory effects of GS - E3D on the formation of advanced glycation end products ( AGEs ) and their cross - linking with
collagen in vitro and in
streptozotocin - induced
diabetic rats . -
pubmed
HLA class I expression predicts prognosis and therapeutic benefits from
tyrosine kinase inhibitors in metastatic
renal - cell carcinoma patients . -
pubmed
PURPOSE : Classical
HLA class I antigen is highly involved in antigen presentation and adaptive immune response against
tumor . -
pubmed
EXPERIMENTAL DESIGN : A TKI cohort of 111
mRCC patients treated with
sunitinib or
sorafenib and a non - TKI cohort of 160
mRCC patients treated with
interleukin-2 or
interferon - alpha - based immunotherapy at a single institution were retrospectively enrolled . -
pubmed
HLA class I expression was associated with CTL infiltration and function , and its prognostic value was more predominant in CTL high - density
tumors ( P & lt ; 0.001 ) rather than CTL low - density
tumors ( P = 0.294 ) . -
pubmed
CONCLUSIONS : Classical
HLA class I expression can serve as a potential predictive biomarker for TKI therapy in
mRCC patients . -
pubmed
HIL group
patients had higher
albumin ( 3.3 vs. 2.9 g / dL ; P<0.001 ) and lower
C - reactive protein ( 6.4 vs. 8.1 mg / L ; P<0.001 ) postoperatively . -
pubmed
Brain - derived neurotrophic factor (
BDNF ) is a crucial regulator to support synaptic plasticity and neuronal survival , its significant decrease is a pathophysiological hallmark in
Alzheimer ' s disease (
AD ) brains and accounts for poor prognosis . -
pubmed
Here we observed miR-322 is significantly increased along with
BDNF decrease in
AD mouse brain . -
pubmed
Collectively , this study demonstrated a novel miRNA - dependent manner of
BDNF degradation in
AD pathogenesis , it may drive a miRNAs- or
BDNF based therapeutic strategies against
Alzheimer ' s disease . -
pubmed
Correction : Synergistic Interaction between the
HDAC Inhibitor ,
MPT0E028 , and
Sorafenib in
Liver Cancer Cells In Vitro and In Vivo . -
pubmed
Sympathetic nervous remodeling is induced in the intermediolateral nucleus after
myocardial infarction - Role of
BDNF -
TrkB axis . -
pubmed
The mRNA and protein expressions of
brain - derived neurotrophic factor (
BDNF ) ,
tropomyosin - related kinase receptor (
TrkB ) and
extracellular signal - regulated kinase (
ERK ) were measured by quantitative RT - PCR , immunohistochemistry and Western blotting 1 week after
MI . -
pubmed
The density of
growth - associated protein-43 , a protein upregulated in axons undergoing nerve sprouting , was increased after
MI compared to sham . -
pubmed
The fluorescence intensity of
BDNF and
TrkB in IML were significantly higher in the
MI group than in the sham group . -
pubmed
In addition , mRNA expressions of
BDNF and
TrkB in the spinal cord at the Th2 level was increased after
MI . -
pubmed
In conclusion , neural remodeling after
MI in IML is associated with the activation of
BDNF -
TrkB axis . -
pubmed
RESULTS :
IgM and
IgG donor - specific isoagglutinins ( DSIs ) of 31 cases of
TPE were significantly decreased after three consecutive TPEs (
IgM median , 1:32 to 1:2 , P & lt ; .0001 ;
IgG median , 1:256 to 1:8 , P & lt ; .0001 ) . -
pubmed
Here , to better understand the pathogenesis of
MERS - CoV , we studied the role of pyroptosis in
THP-1 cells and
hDPP4 Tg
mice with
MERS - CoV infection . -
pubmed
The
hDPP4 - Tg
mice infected with
MERS - CoV overexpressed
caspase-1 in the spleen and showed high
IL-1beta levels in serum , suggesting that pyroptosis occurred after
infection . -
pubmed
Pyroptosis and
inflammation were suppressed by inhibiting
C5aR1 . -
pubmed
Stronger suppression of the digestive protease gene
CatL and elevated basal expression of the stress responsive gene
Hsp27 were observed in F1 larvae with parental
hypoxic experience . -
pubmed
Effects of
thalidomide on Th17 , Treg cells and
TGF - beta1 /
Smad3 pathway in a
mouse model of
systemic sclerosis . -
pubmed
OBJECTIVE : To evaluate the immune regulatory and anti -
fibrosis function of
thalidomide (
Thal ) in
systemic sclerosis (
SSc ) , we investigated the effects of Thal on : ( a ) Th17 and Treg cell production ; ( b ) related factors expression ; and ( c )
transforming growth factor ( TGF )- beta1 /
Smad3 pathway , using a
mouse model of
SSc . -
pubmed
RESULTS :
Thal treatment : ( a ) reduced skin , and pulmonary tissue
fibrosis ,
inflammation score , and
hydroxyproline content ( P & lt ; .001 ) in BLM - induced
SSc mice ; ( b ) reduced the percentages of Th17 cells and associated
interleukin ( IL )- 17A expression ( both P & lt ; .05 ) but increased the percentages of Treg cells and its transcription factor
Foxp3 expression ( both P & lt ; .05 ) ; ( c ) correlation analysis found positive correlations between Th17 / Treg ratio , the inflammatory score of the skin and pulmonary tissues ,
hydroxyproline content , and
type I collagen messenger RNA expression ( r = .8546 , .8656 , .6902 , .6807 , .8118 , and .8424 , respectively , P & lt ; .01 ) ; ( d )
Thal inhibited
TGF - beta1 expression and
Smad3 phosphorylation ( both P & lt ; .05 ) ; ( e )
TGF - beta1 was positively correlated with the
IL-17A and Th17 / Treg ratio ( r = .5856 , P = .005 ; r = .6684 , P = .0107 , respectively ) . -
pubmed
CONCLUSION : Thal can effectively prevent skin and pulmonary tissue
fibrosis in a
mouse model of
SSc through the
TGF - beta1 /
Smad3 signaling pathway and can rectify the distortion of the Th17 / Treg balance in
SSc by potentially regulating Th17 and Treg cell production , as well as their related factors expression . -
pubmed
Influence of the
Hippo -
YAP signalling pathway on
tumor associated macrophages ( TAMs ) and its implications on
cancer immunosuppressive microenvironment . -
pubmed
The
Hippo - Yes - associated protein (
YAP ) signalling pathway is one of the most extensively discussed mechanism for the regulation of
tumour proliferation , migration , angiogenesis , and invasion in recent years . -
pubmed
To date , several studies have revealed that
YAP is involved in the interrelating interactions between
tumour and immune cells , particularly the TAMs . -
pubmed
Caveolar activation counteracted the expression of
wound - protective
epidermal growth factor receptor (
EGFR ) and its target genes , such as
chemokines that were pivotal for epithelial integrity in the ribosome - inactivated gut . -
pubmed
Mechanistic findings regarding ribosomal inactivation - associated disorders in the gut barrier provide crucial molecular evidence for detrimental caveolar actions against
EGFR - mediated epithelial protection in
patients with
IBD . -
pubmed
CD123+
CD4+
CD56 +
neoplasm :
blastic plasmacytoid dendritic cell neoplasm or
acute myeloid leukemia ? -
pubmed
Different measurements of thyroid function including I123 thyroid scanning were performed in 16
hypothyroid infants diagnosed by a
TSH screening project . -
pubmed
Thyroglobulin may have a role in the diagnosis of
athyrosis . -
pubmed
The levels of
C3 ,
cholinesterase ,
albumin and
prothrombin were determined in 46
patients ( 27
males and 19
females ) - 26 with
cirrhosis of the liver , 9 with
acute hepatitis , 6 with
chronic aggressive hepatitis , 1 with
chronic persistent hepatitis and 4 with
fatty liver . -
pubmed
In all
patients and , particularly in those with
cirrhotic liver , it was shown that the normal or pathological level of serum C 3 is related both qualitatively and quantitatively to the normal or pathological levels of
cholinesterase ,
albumin , and
prothrombin . -
pubmed
The determination of the range of confidence for the 4 parameters showed that , in the
patients with
hepatic coma ,
cholinesterase reacted most sensitively to
liver damage ( 0.5 - 0.94 ) followed by
C3 and
prothrombin ( 0.33 - 0.81 ) . -
pubmed
Also in the cases without
hepatic coma ,
cholinesterase was the most sensitive indicator ( 0.05 - 0.29 ) , followed by
prothrombin ( 0.03 - 0.24 ) ,
albumin and
C3 ( 0.00 - 0.16 ) . -
pubmed
We analyzed weight of body , spleen and thymus ; antibody response and delayed - type
hypersensitivity response to
ovalbumin immunization ; and ( immuno)histopathology of spleen , lymph nodes , and lymphoid tissue along the gastrointestinal tract . -
pubmed
Rather , the response in
primo - infection to
Rat Corona Virus ,
Sendai Virus , and
Pneumonia Virus of
Mice was the highest in animals clustered as " fast - and high " responders to
ovalbumin . -
pubmed
The aim of the present study was to see if female alcoholics had low platelet
MAO activity and whether there was a correlation between low
MAO activity in female alcoholics and specific clinical characteristics often observed in
type II male alcoholics . -
pubmed
Type II alcoholics were characterized by early onset , a high frequency of
depression and
alcoholism in first degree relatives , a high frequency of
drug abuse and social complications , sensation seeking behavior , extraversion ,
impulsive sensation seeking psychopathy , and low platelet
MAO activity . -
pubmed
They did not have early onset , higher frequency of
depression or
alcoholism in their first degree relatives , nor more social complications than the female alcoholics with normal platelet
MAO activity . -
pubmed
We have studied
methanol - utilization in a
peroxisome - deficient (
PER ) mutant of
Hansenula polymorpha . -
pubmed
In this study ,
HBsAg ,
HBcAg and
HBV DNA in myeloid cells of 57 patients with
hepatitis have been examined by using ABC staining method . -
pubmed
The results show that in the myeloid cells of 54 patients with positive HBVM in serum , there are 4 cases with
HBV positive antigen ,
HBcAg has been found in a case of acute
hepatitis and
HBsAg in a case of
chronic hepatitis and a case of
liver cirrhosis respectively ,
HBsAg and
HBcAg were found simultaneously in another case of
liver cirrhosis . -
pubmed
Interaction of
1,25 - dihydroxyvitamin D and
plasma renin activity in high
renin essential
hypertension . -
pubmed
In 10
subjects with high
renin hypertension , an increase in dietary
sodium intake resulted in an increase in urinary
calcium excretion ( 2.5 to 3.4 mmol / L , P = .011 ) and an increase in serum
1,25 - dihydroxyvitamin D ( 51.2 to 61.0 pmol / L , P = .045 ) . -
pubmed
Therefore ,
1,25 - dihydroxyvitamin D may be a mediator in the response of high
renin hypertension to increased
sodium intake . -
pubmed
We reported a 34 - year - old female
patient with refractory
idiopathic thrombocytopenic purpura (
ITP ) in whom a subacute
subdural hematoma occurred without any preceding
trauma during
danazol administration which resulted in a marked decrease of plasma
fibrinogen level . -
pubmed
Structural aberrations of the
retinoblastoma locus (
RB1 ) were observed in 25 % of
breast tumor cell lines studied and 7 % of the primary
tumors . -
pubmed
No obvious defect in
RB1 was detected by DNA blot analysis in primary
tumors or cell lines from
Wilms ' tumor ,
cervical carcinoma , or
hepatoma . -
pubmed
These results further support the concept that the
human RB1 gene has pleiotropic effects on specific types of
cancer . -
pubmed
[ Arterial
hypertension in
renin - producing
retroperitoneal leiomyosarcoma ] . -
pubmed
A case report of an extrarenal retroperitoneal metastatic
leiomyosarcoma with associated paraneoplastic
renin production is presented . -
pubmed
Due to the
renin excess syndrome , accelerated
hypertension was present combined with the signs of secondary
hyperaldosteronism ,
hypokalemia , and
alkalosis . -
pubmed
In contrast to other publications of extrarenal
malignoma with paraneoplastic
renin activity , this case elucidates a histologically close relationship to epitheloid muscle cells of kidney vasa afferentia and derived
benign tumors . -
pubmed
In contrast to histological criteria only the primary
tumor exhibited high
renin activity , no activity could be detected in the metastase . -
pubmed
Lactoferrin in synovial fluid of
patients with
inflammatory arthritis . -
pubmed
Fecal
chymotrypsin concentrations were subnormal in five
patients with
chronic pancreatitis , borderline in one
patient with relapsing
pancreatitis , subnormal in one patient after pancreatectomy , and subnormal in five of nine with
carcinoma of the pancreas . -
pubmed
Subnormal concentrations of fecal
chymotrypsin were found in seven of 21
patients with
chronic liver disease related to
alcoholism , eight of 32 with a partial gastrectomy , three of 10 with adult
celiac disease and five of 16 with
psoriasis . -
pubmed
It appears that the determination of fecal
chymotrypsin concentrations provides a valuable screening test for
pancreatic exocrine deficiency . -
pubmed
Failure of short - term
hyperprolactinaemia to increase the number of
gonadotrophin receptors in the ram testis . -
pubmed
( 1 ) The usefulness of
complement fixation antigen (
CFA ) antibodies ,
nuclear inclusion antigen (
NIA ) antibodies and
pre - early nuclear antigen (
PENA ) antibodies in serum as markers for serological diagnosis of
CMV infection was evaluated from the viewpoint of sensitivity of CF , IF , and ACIF antibody detection methods . -
pubmed
Enzymatic activity of
renin in plasma of normal and
uraemic subjects . -
pubmed
PRR is increased in plasma of
patients with
renal failure compared with that of normal subjects . -
pubmed
The present study was carried out to determine if increased
PRR in
uraemic plasma is related to differences of endogenous active or inactive
renin , endogenous
renin substrate , or pH of the incubation in vitro . -
pubmed
PRR in plasma of ten
uraemic patients was greater ( P less than 0.02 ) than that in plasma of ten normal
subjects in incubations carried out at pH 7.4 and 5.7 . -
pubmed
After addition of
renin ,
renin concentration ( measured by direct radioimmunoassay ) did not differ in normal and
uraemic plasma . -
pubmed
These observations are consistent with our earlier hypothesis that there is a deficiency of a
renin inhibitor in
uraemic plasma . -
pubmed
Nitric oxide synthase and
VIP distribution in enteric nervous system in
idiopathic chronic constipation . -
pubmed
Idiopathic chronic constipation has been correlated to
neural abnormalities that consist of a reduced number of myenteric plexus neurons and a decreased concentration of
VIP - positive nerve fibers within the circular muscle . -
pubmed
The density of
VIP- and
nitric oxide - producing neurons was evaluated by immunocytochemistry using anti -
VIP and anti -
nitric oxide synthase antibodies in five
patients with
idiopathic chronic constipation . -
pubmed
Distinct patterns of expression of
intercellular adhesion molecule-1 ,
vascular cell adhesion molecule-1 , and
endothelial - leukocyte adhesion molecule-1 in
renal disease . -
pubmed
Expression of
intercellular adhesion molecule-1 was significantly increased on parietal epithelium of glomeruli in
membranous nephropathy and
Henoch - Schonlein purpura , on mesangium in
Henoch - Schonlein purpura ,
membranoproliferative glomerulonephritis and
IgA nephropathy , and in small interstitial vessels in
membranous nephropathy and
membranoproliferative glomerulonephritis . -
pubmed
Interstitial infiltrates contained only few
intercellular adhesion molecule-1 - positive cells in
Henoch - Schonlein purpura and
IgA nephropathy . -
pubmed
Kidneys with
lupus nephritis and
Henoch - Schonlein purpura demonstrated an increase of
endothelial - leukocyte adhesion molecule-1 on parietal epithelium of glomeruli and on tubular epithelium . -
pubmed
CONCLUSIONS : These results show for the first time ( a ) endothelial
vascular cell adhesion molecule-1 induction in various
glomerulonephritides and ( b )
endothelial - leukocyte adhesion molecule-1 induction in the kidney . -
pubmed
Histological examination of the
tumor revealed a fasciculated proliferation of spindle cells that proved to be immunoreactive to
vimentin only ; pleomorphism was mild ,
necrosis extensive and mitotic count high . -
pubmed
We conclude that periplasmic
Cu ,
Zn SOD contributes to the virulence of
Neisseria meningitidis , most likely by reducing the effectiveness of toxic
oxygen host defenses . -
pubmed
OBJECTIVE : The present study was designed to prove the existence of apoptosis in
retinoblastoma ( Rb ) and to determine the pathogenic mechanism of spontaneous regression of
Rb as well as the relationship between them . -
pubmed
[ The effect of pharmacologic prophylaxis with
Panpal on
acetylcholinesterase activity in the diaphragm and various parts of the brain in
rats during treated and untreated Soman
poisoning ] . -
pubmed
METHODS AND RESULTS : The influence of the pharmacological prophylaxis with
Panpal (
pyridostigmine in combination with
benaetyzine and
trihexyphenidyle ) on
acetylcholinesterase activity in diaphragm and various parts of brain at 1 and 3 h following non - treated and treated ( the
oxime HI-6 in combination with
atropine ) soman
poisoning was tested on male
rats . -
pubmed
While
Panpal did not significantly influence the
acetylcholinesterase activity in brain following non - treated as well as treated soman
poisoning . -
pubmed
Panpal increased so many - induced
acetylcholinesterase inhibition following non - treated
poisoning and decreased the reactivating effect of the
oxime HI-6 following treated soman
poisoning in diaphragm . -
pubmed
CONCLUSIONS : Our data confirm the importance of the combination of reversible
acetylcholinesterase inhibitor
pyridostigmine with anticholinergic drugs in the pharmacological prophylaxis of soman
poisoning because of the elimination of consequences of
pyridostigmine - induced increasing in
acetylcholinesterase inhibition in the peripheral compartment . -
pubmed
Measurements were made before stopping treatment , at discontinuation of
GH treatment , and two weeks , six months , and one year later in 11
adolescents with
growth hormone deficiency (
GHD ) and five
adolescents without
GHD who were treated with GH . -
pubmed
RESULTS : During the nine months before discontinuation of
GH there were no changes in body composition , RMR , or BMC of
patients with
GHD , nor differences when compared with controls . -
pubmed
RMR was reduced by 11.3 kJ / kg fat free mass two weeks after stopping
GH in
GHD patients and remained suppressed thereafter compared with controls . -
pubmed
Percentage body fat increased by 4.3%/year in
patients with
GHD after discontinuing
GH , whereas no changes were noted in control or non - GHD
patients at one year . -
pubmed
The high amount of
sMR released by DC and its ability to bind mannosylated ligand might indicate that this
molecule plays a role in the transport of mannosylated proteins from the site of
inflammation to other parts of the body . -
pubmed
Is isolated
idiopathic pancreatitis associated with
CFTR mutations ? -
pubmed
It is concluded that
orexin - A may play an important physiological role in regulating the sleep - wake state , a hypothesis considerably strengthened by the recently reported
narcoleptic phenotype of prepro - orexin ( the precursor for
orexin - A ) knockout
mice . -
pubmed
Suppressive effects of dominant negative
ras mutant N116Y on transformed phenotypes of
human bladder cancer cells . -
pubmed
To investigate the suppressive effect of dominant negative
H - ras mutant N116Y on transformed phenotypes , we established two N116Y
ras mutant stable transfectant clones (
C5 ,
C13 ) of
human bladder cancer cell line ,
UMUC-2 . -
pubmed
Cardiac operation in a
patient with combined homozygous
protein C and
protein S deficiency . -
pubmed
Although this did not impact on cerebral perfusion or clinical outcome in
patients with
acute ischemic stroke in this report , we propose that
ER deserves to be further evaluated by initiating the first treatment within 6 h post - insult . -
pubmed
Interleukin-12 in the treatment of
chronic hepatitis B and C.
Interleukin-12 plays a central role in mounting an effective cellular immune response directed towards elimination of intracellular pathogens . -
pubmed
In two open label , multicenter , dose - escalation phase I / II studies tolerability , pharmacokinetics , pharmacodynamics , and efficacy of subcutaneously administered recombinant
human interleukin-12 (
rHuIL-12 ) was assessed in the treatment of
chronic hepatitis B and C. Forty - six
patients with
chronic hepatitis B and 60
patients with
chronic hepatitis C were treated for 12 and 10 consecutive weeks , respectively . -
pubmed
ERCC1 and
thymidylate synthase mRNA levels predict survival for
colorectal cancer patients receiving combination
oxaliplatin and
fluorouracil chemotherapy . -
pubmed
PURPOSE : To test the hypotheses of whether the relative mRNA expression of the
thymidylate synthase (
TS ) gene and the excision cross - complementing (
ERCC1 ) gene are associated with response to and survival of
fluorouracil (
5 - FU )/ oxaliplatin chemotherapy in metastatic
colorectal cancer . -
pubmed
cDNA was derived from paraffin - embedded
tumor specimens to determine
TS and
ERCC1 mRNA expression relative to the internal reference gene
beta - actin using fluorescence - based , real - time reverse transcriptase polymerase chain reaction . -
pubmed
RESULTS : The median
TS gene expression level from 50 metastasized
tumors was 3.4 x 10(-3 ) ( minimum expression , 0.18 x 10(-3);maximum expression , 11.5 x 10(-3 ) ) , and the median
ERCC1 gene expression level was 2.53 x 10(-3 ) ( minimum , 0.0 ; maximum , 14.61 x 10(-3 ) ) . -
pubmed
The gene expression cutoff values for chemotherapy nonresponse were 7.5 x 10(-3 ) for
TS and 4.9 x 10(-3 ) for
ERCC1 . -
pubmed
CONCLUSION : These data suggest that intratumoral
ERCC1 mRNA and
TS mRNA expression levels are independent predictive markers of survival for
5 - FU and
oxaliplatin combination chemotherapy in
5 - FU - resistant metastatic
colorectal cancer . -
pubmed
As well as the classical mucosa - associated lymphoid tissue cellular infiltrate , immunohistochemical characterization of the 14 mucosa - associated lymphoid tissue - type
lymphomas revealed the
CD20+/CD43 + centrocyte - like cell phenotype in 10 cases ( 71.5 % ) . -
pubmed
Although the
lymphoepithelial lesions observed in all lymphomatous cases have been reported in
lung lymphoid hyperplasia , the determination of B - cell
CD20+/CD43 + phenotype of the intraepithelial lymphocytes highly increased the specificity of
lymphoepithelial lesions . -
pubmed
We show that 17beta - E2 represses
EGF - induced activation of the
Raf - to -
Erk pathway in
human breast carcinoma cells that express
GPR30 , including
MCF-7 and
SKBR3 cells which express both or neither ,
ER , respectively . -
pubmed
Extensive labelling for the apoptotic markers
calcium channel receptor
P2X ( 7 ) and
caspase-3 and
telomerase activity was co - localized at a similar intensity in areas affected by superficial spreading
melanoma obtained from 80
patients . -
pubmed
Conversely , the
calcium - regulating receptors
P2X ( 1 - 3 ) and
P2Y ( 2 ) ( found in
normal but not
neoplastic skin ) were fully de - expressed within 2 microm of the
melanoma but fully expressed beyond that distance . -
pubmed
The cell adhesion protein
E - cadherin ( also only present in
normal skin ) was progressively de - expressed from a point 2 microm from the
melanoma until full de - expression within the lesion . -
pubmed
These results show that
telomerase - induced proliferation and defensive apoptosis are co - localized and simultaneous processes in
melanoma tissue . -
pubmed
Melanoma cell proliferation appears to overwhelm the apoptotic defence , perhaps due to the anti - apoptotic effects of
telomerase . -
pubmed
[ Prolonged
insulin coma ; therapeutic effect of
ANP-235 ] . -
pubmed
There was no convincing evidence of reaccumulation of
iron in the grafted liver in
HH ; however , 1 subject demonstrated increased serum
ferritin concentration and grade 2
hepatic siderosis . -
pubmed
Studies of bone turnover in women with sustained exercise - associated
amenorrhea using metabolic markers of osteoblast activities and
collagen synthesis have demonstrated an apparent reduction of bone formation that is associated with a low body mass index ( BMI ) and with endocrine disturbances that are characteristic of energy deficit . -
pubmed
Moreover , a number of pathological and pharmacological studies on
sporadic PD and dopaminergic neurotoxin - induced
parkinsonism have hypothesized that
mitochondrial dysfunction ,
inflammation , oxidative stress , and dysfunction of the
ubiquitin - proteasome system all play important roles in the pathogenesis and progress of
PD . -
pubmed
Intravenous thrombolysis with recombinant
tissue plasminogen activator is the established treatment for
acute ischemic stroke patients presenting within 3 h after
stroke onset . -
pubmed
Only one case with a somatic
MEN1 mutation was identified ( 1527del7bp ) , indicating that the
MEN1 gene plays a minor pathogenic role in
sporadic insulinomas . -
pubmed
The results allow an understanding of the active site specificity of the
C1s protease for the first time and provide a basis for the development of specific inhibitors aimed at controlling
inflammation associated with complement activation in adverse pathological situations . -
pubmed
The encouraging responses seen in this early study suggest further evaluation of
epidermal growth factor receptor and
cyclooxygenase-2 inhibitors in
SCCHN is warranted . -
pubmed
Ghrelin improves endothelial function in
patients with
metabolic syndrome . -
pubmed
This study therefore investigated whether
ghrelin administration might beneficially affect endothelial function in
metabolic syndrome . -
pubmed
In
patients with
metabolic syndrome , basal plasma
ghrelin was significantly lower than in controls ( P=0.02 ) . -
pubmed
This effect was likely related to enhanced
nitric oxide bioavailability because , in a group of
patients with
metabolic syndrome ( n=6 , 2 female ) ,
ghrelin had no effect on the vasodilator response to
acetylcholine ( P=0.78 versus saline ) after
nitric oxide inhibition by
NG - monomethyl - L - arginine . -
pubmed
CONCLUSIONS : These findings indicate that
ghrelin reverses
endothelial dysfunction in
patients with
metabolic syndrome by increasing
nitric oxide bioactivity , thereby suggesting that decreased circulating levels of the peptide , such as those found in these
patients , might play a role in the pathobiology of
atherosclerosis . -
pubmed
Neutralizing antibody responses of
pigs infected with natural
GP5 N - glycan mutants of
porcine reproductive and respiratory syndrome virus . -
pubmed
In order to assess the effect of the N - glycans associated with the
GP5 neutralization epitope of
porcine reproductive and respiratory syndrome virus (
PRRSV ) on the neutralizing antibody ( Ab ) response of
swine , groups of young
pigs were infected with
PRRSV strains differing in N - glycosylation pattern . -
pubmed
In addition ,
viremia was monitored by quantitative RT - PCR , and
anti - N - protein Ab formation was measured by HerdChek ELISA . -
pubmed
Some
pigs generated high titers of
peptide binding Abs between 7 and 28 days post
infection ( p.i . ) -
pubmed
In the present study we have studied the in vitro effects of hyperbaric
oxygen on proliferation of
human fibroblasts from normal skin and from
chronic foot ulcers in non -
insulin - dependent
diabetics . -
pubmed
Even though there are some critical obstacles to inhibit effective
tumour immunity ,
tumour cells are able to exploit the functional roles of iDCs for
tumour progression , which are induced by tumour - derived soluble factors such as
vascular endothelial growth factor (
VEGF ) and functionally modulated in the microenvironment . -
pubmed
These fractions induced DNA ladder and
caspase-3 activation during apoptosis in colon 26
tumor cells . -
pubmed
These results indicate that the
dichloromethane extract of PBL includes anticancer components composed of at least three
fatty acids , and apoptosis - inducing activity of the extract was mediated by
caspase-3 activation in
tumor cells . -
pubmed
Examining the relationship between
Cu - ATSM
hypoxia selectivity and
fatty acid synthase expression in
human prostate cancer cell lines . -
pubmed
METHODS :
Human prostate tumor - cultured cell lines (
PC-3 ,
22Rv1 ,
LNCaP and
LAPC-4 ) , were treated with a
fatty acid synthase (
FAS ) inhibitor ( C75 , 100 microM ) under
anoxia . -
pubmed
CONCLUSIONS : Although
Cu - ATSM has clinical relevance in the PET imaging of
hypoxia in many
tumor types , its translation to the imaging of
prostate cancer may be limited by the overexpression of
FAS associated with
prostatic malignancies . -
pubmed
Association , expression , pathobiology : is too much
tau in
PD a blueprint for genetic association ? -
pubmed
Laboratory investigation of the initial 29 suspect - case blood specimens by classic methods ( antigen capture ,
IgM and
IgG ELISA ) and a recently developed random - primed pyrosequencing approach quickly identified this to be an Ebola
HF outbreak associated with a newly discovered ebolavirus species (
Bundibugyo ebolavirus ) distantly related to the
Cote d'Ivoire ebolavirus found in western Africa . -
pubmed
Evaluation of an
interferon - gamma release assay , T - SPOT.TB , in a population with a low prevalence of
tuberculosis . -
pubmed
OBJECTIVE : To compare the performance of an
interferon - gamma release assay ( T - SPOT.TB ) and tuberculin skin test ( TST ) in a population with a low prevalence of
tuberculosis (
TB ) that was predominantly US - born and not bacille Calmette - Guerin - vaccinated . -
pubmed
INH - associated
hepatitis ( INH -
hepatitis ) was defined as having either
alanine or
aspartate aminotransferase greater than 5.0 times the upper limit of normal regardless of symptoms when
INH was not excluded as the cause . -
pubmed
RESULTS : Concentrations of small
HDL particles were lower in
patients with
RA ( 18.2 + /- 5.4 nmol / l ) than controls ( 20.0 + /- 4.4 nmol / l ; p = 0.003 ) . -
pubmed
In
patients with
RA , small
HDL concentrations were inversely associated with DAS28 ( rho = -0.18 , p = 0.04 ) and
C - reactive protein ( rho = -0.25 , p = 0.004 ) . -
pubmed
Concentrations of small
HDL were lower in
patients with
coronary calcification ( 17.4 + /- 4.8 nmol / l ) than in those without ( 19.0 + /- 5.8 nmol / l ; p = 0.03 ) . -
pubmed
Concentrations of small
LDL particles were lower in
patients with
RA ( 1390 + /- 722 nmol / l ) than in controls ( 1518 + /- 654 nmol / l ; p = 0.05 ) , but did not correlate with DAS28 or CAC . -
pubmed
CONCLUSION : Low concentrations of small
HDL particles may contribute to increased
coronary atherosclerosis in
patients with
RA . -
pubmed
We further discuss mechanisms by which inhibition of
PAK1 can arrest
tumor growth and promote cell apoptosis , and the types of
cancers in which
PAK1 inhibition may hold promise . -
pubmed
BACKGROUND :
Secondary hyperparathyroidism (
SHPT ) , known complication of
chronic renal failure , in addition to effects on bone and cardiovascular systems , is associated with reduced response to
erythropoietin (
EPO ) . -
pubmed
PATIENTS AND METHODS : Using a retrospective chart - based review of dialysis
patients ' records to identify
patients being treated with either
cinacalcet or
paricalcitol alone , matched for the same
EPO treatment , which had been followed for 1 year , we have evaluated the effect of
cinacalcet on
anemia compared to that of
paricalcitol . -
pubmed
CONCLUSION : The combination of lower
EPO dose in
cinacalcet - treated
patients compared with
paricalcitol - treated
patients , along with good
SHPT control is a novel information and might have considerable benefits in dialysis
patients not only preventing bone (
fractures ) and cardiovascular system ( calcifications ) damages but also in terms of cost savings via a reduction of
EPO dosage . -
pubmed
Exposure of 100ppm
PTU significantly increased virus titers in the lungs of
RSV - infected offspring compared with the control , and the 10ppm also elevated levels of
interferon - gamma , a marker of
pneumonia , in the bronchoalveolar lavage fluids of offspring . -
pubmed
After univariate and multivariate analyses of the clinical variables , age , T classification , N classification , site of metastases , secondary metastases and
disease - free interval ( DFI ) correlated with OS , whereas age , VCA -
IgA titre , number of metastases and secondary metastases were related to LMS . -
pubmed
We investigated the effects of
angiotensin II (
ANG II)-dependent
hypertension on the platelet proteome . -
pubmed
METHODS AND RESULTS :
Hypertension was induced in
cyp1a1ren-2 transgenic
rats by feeding
indole-3 - carbinol ( n = 10 ) and in
Fischer 344 rats by subcutaneously infusing
ANG II ( n = 7 ) . -
pubmed
Repeated blood withdrawals and stimulation of megakaryocytopoiesis by a
thrombopoietin receptor agonist induced changes in the same protein spots but in the opposite direction to those induced by
ANG II - dependent
hypertension . -
pubmed
CONCLUSION :
ANG II - dependent
hypertension is associated with enhanced protein degradation in platelets . -
pubmed
Comparison of
E - selectin and the other inflammatory markers in
lumbar disc herniation : a new promising therapeutical window for
radicular pain . -
pubmed
OBJECTIVE : The aim of this study was to investigate the prevalence of inflammatory cells in
lumbar disc herniations (
LDH ) and compare the prevalence of
leukocyte adhesion protein "
E - selectin " with other inflammatory cells such as T cells , B cells , and macrophages . -
pubmed
SUMMARY OF BACKGROUND : Studies on inflammatory cells and biochemical mediators of
inflammation have suggested that these factors may play an important role in pathophysiology of
radicular pain , and the medical therapy was formed against to block these cells and inflammatory
cytokines . -
pubmed
METHODS : The herniated disc specimens obtained from 50
patients who had unilateral persistent
radicular pain or unilateral radicular motor
paresis were microscopically examined after staining with monoclonal antibodies of
CD20 ,
CD45 ,
CD68 , and
E - selectin . -
pubmed
CONCLUSIONS : We suggest that
E - selectin is as valuable as the other well - known inflammatory markers in the pathogenesis of
LDH . -
pubmed
In our opinion , beside the well - known nonsteroidal anti - inflammatory drugs , antagonists targeting
E - selectin can be potentially effective therapeutics for controlling
inflammation in LDH . -
pubmed
( 2007 ) linked the circadian clock gene
Bmal1 to
hypertension and
metabolic dysfunction in the SHR . -
pubmed
Heart failure was associated with marked effects on the expression of
Bmal1 ,
Clock and
Rora in addition to several non - circadian genes important in regulating skeletal muscle phenotype including
Mck ,
Ttn and
Mef2c . -
pubmed
We found that
hypertensive /
hypertrophic SHR showed a dampening of peak
Bmal1 and
Rev - erb expression in the liver , and the clock - controlled gene
Pgc1alpha in the gastrocnemius . -
pubmed
In addition , the core - clock gene Clock and the muscle - specific , clock - controlled gene
Myod1 , no longer maintained a circadian pattern of expression in gastrocnemius from the
hypertensive SHR . -
pubmed
These findings provide a framework to suggest a mechanism whereby chronic
heart failure leads to skeletal muscle pathologies ; prolonged dysregulation of the molecular clock in skeletal muscle results in altered
Clock ,
Pgc1alpha and
Myod1 expression which in turn leads to the mis - regulation of target genes important for mechanical and metabolic function of skeletal muscle . -
pubmed
Immunohistochemical staining of the
tumor was positive for
EMA and
CD34 , but negative for
CEA ,
Ki67 , and
GFAP . -
pubmed
Immunohistochemical staining of proliferating vessels in the periphery of the
tumor was positive for
CD34 . -
pubmed
Overactive
bone morphogenetic protein signaling in
heterotopic ossification and
Duchenne muscular dystrophy . -
pubmed
BMP signaling is precisely regulated and perturbation of
BMP signaling is connected to multiple diseases , including
musculoskeletal diseases . -
pubmed
In this review , we will summarize the recent progress in elucidation of
BMP signal transduction , how overactive
BMP signaling is involved in the pathogenesis of
heterotopic ossification and
Duchenne muscular dystrophy , and discuss possible therapeutic strategies for treatment of these diseases . -
pubmed
RESULTS : At baseline , the
PCOS patients and controls had similar body composition , lipids ,
insulin resistance and
glucose metabolism parameters . -
pubmed
Total and trunk fat percentages were negatively correlated with
sex hormone binding globulin and were positively correlated with homeostatic model assessment of
insulin resistance and free
androgen index in the
PCOS group .. After 6 months of treatment in the
PCOS patients , total fat percentage increased from 24.5%+-7.1 % to 26.0%+-6.1 % ( p=.035 ) and trunk fat percentage increased from 20.2%+-8.9 % to 22.2%+-7.1 % ( p=.014 ) , although weight , BMI and waist to hip ratio ( WHR ) remained unchanged . -
pubmed
Clinical impact of extended - spectrum
beta - lactamase - producing Enterobacteriaceae in patients with
biliary tract infection . -
pubmed
BACKGROUND : Clinical outcomes associated with Gram - negative bacterial isolates with extended spectrum
beta - lactamase (
ESBL ) in patients with
biliary tract infection are largely unknown . -
pubmed
[ Successful treatment of trastuzumab - resistant
HER2 - positive
breast cancer with extensive
liver metastases using the combination of trastuzumab and
capecitabine - a case report ] . -
pubmed
We report a case of a trastuzumab - resistant
human epidermal growth factor receptor-2(
HER2)-positive
breast cancer patient with extensive
liver metastases and associated
impaired liver function , who showed an excellent response to the combination of trastuzumab and
capecitabine . -
pubmed
Pigmented hepatocellular adenoma with complete
CD34 immunostaining pattern : a diagnostic dilemma . -
pubmed
We labeled the
tumor as pigmented
hepatic adenoma with complete
CD34 staining pattern . -
pubmed
Even though it is likely that there is no single source for all myofibroblasts , a common mechanism for the production of
fibrosis is via the
transforming growth factor - beta / phosphorylated
Smad3 pathway . -
pubmed
Inhibition of
histone deacetylase 3 causes replication stress in
cutaneous T cell lymphoma . -
pubmed
In fact , two
histone deacetylase inhibitors ( HDIs ) ,
SAHA and
Depsipeptide , are FDA approved for single - agent treatment of refractory
cutaneous T cell lymphoma (
CTCL ) . -
pubmed
These results suggest that selective inhibition of
HDAC3 could be useful in treatment of
CTCL by disrupting DNA replication of the rapidly cycling
tumor cells , ultimately leading to cell death . -
pubmed
METHODS : We investigated the relationship of baseline and on - treatment
CRP with subsequent CV events in Cox models using a subset of white subjects with no history of
CV disease from the UK ASCOT ( Anglo - Scandinavian Cardiac Outcomes Trial ) . -
pubmed
We reported a patient whose bone marrow features resembled
acute myeloid leukaemia with predominantly agranular blasts , devoid of Auer rods and expressing
CD34 and
HLA - DR on flow cytometry . -
pubmed
METHODS : In total , 70 native liver biopsies of 44
biliary atresia patients were obtained at PE ( n=30 ) , 4.2 years after successful PE ( n=23 ) and 1.1 years after failed
PE ( n=17 ) , and reviewed for
cholestasis ,
fibrosis ,
inflammation , and
cytokeratin 7 (
CK7 ) immunopositivity (
chronic cholestasis ) . -
pubmed
Nevertheless , enhanced
fibrosis [ Metavir stage 2 ( 1 - 4 ) vs. 4 ( 1 - 4 ) ] , bile duct proliferation [ grade 2 ( 1 - 2 ) vs. 1 ( 0 - 2 ) ] , and periportal
CK7 immunostaining [ grade 1 ( 0 - 2 ) vs. 1 ( 0 - 4 ) ] persisted in 100 % , 87 % , and 61 % of subjects , respectively . -
pubmed
Metavir
fibrosis stage corresponded
cirrhosis ( stage 4 ) in 52 % of the
patients , associated with the presence of
portal hypertension , and correlated with serum - conjugated
bilirubin ( r=0.601 , P=0.002 ) , bile duct proliferation ( r=0.657 , P=0.001 ) , and
CK7 positivity ( r=0.657 , P=0.001 ) . -
pubmed
Aspartate transferase to platelet ratio index predicted native
liver fibrosis and development of
esophageal varices . -
pubmed
CONCLUSIONS : Despite resolution of
cholestasis and decreasing
inflammation , bile duct proliferation , periportal
CK7 immunostaining , and
fibrosis persist after successful PE . -
pubmed
Fibrosis is associated with biochemical
cholestasis , bile duct proliferation ,
CK7 immunopositivity (
chronic cholestasis ) , and development of
portal hypertension . -
pubmed
Activated leukocyte cell adhesion molecule (
CD166 ): an " inert "
cancer stem cell marker for
non - small cell lung cancer ? -
pubmed
Recently , the
activated leukocyte cell adhesion molecule (
CD166 ) was identified as an " inert "
cancer stem cell ( CSC ) marker for
non - small cell lung cancer (
NSCLC ) . -
pubmed
Few data exist regarding the clinical relevance of
CD166 expression in
NSCLC . -
pubmed
We evaluated the expression of
CD166 using immunohistochemistry in a large cohort of
NSCLC patients ( n = 1,910 ) on a tissue microarray basis . -
pubmed
Due to the results of this study , the theory of
CD166 as a CSC marker for
NSCLC must be questioned . -
pubmed
The association of
CD166 with smaller
tumors and no nodal metastases does not make it a typical CSC marker . -
pubmed
Further studies are required to investigate the functional role of
CD166 in
NSCLC . -
pubmed
Multivariate regression demonstrated that significant variables for postoperative hip flexion were degree of preoperative flexion
contracture , preoperative level of
C - reactive protein , use of a 32 - mm femoral head , and postoperative
heterotopic ossification . -
pubmed
The
HPV + head and neck cancer - specific gene set included various metabolism - related pathways , and the
HPV - head and neck cancer - specific gene set included several pathways ; fibroblast ,
collagen degradation ,
actin - binding , and
actin cytoskeleton . -
pubmed
A
Rb1 promoter variant with reduced activity contributes to
osteosarcoma susceptibility in irradiated
mice . -
pubmed
RESULTS : A common
Rb1 allele derived from the BALB / cHeNhg strain was identified as the major determinant of radiation - induced
OS risk at this locus . -
pubmed
CONCLUSION : This is the first experimental demonstration of a functional and genetic link between reduced
Rb1 expression from a common promoter variant and increased
tumor risk after radiation exposure . -
pubmed
Here , using optical molecular imaging , we demonstrate that the
alarmin S100A8 /
S100A9 serves as a sensitive local and systemic marker for the detection of even sub - clinical disease activity in inflammatory and immunological processes like irritative and
allergic contact dermatitis . -
pubmed
In a model of collagen - induced
arthritis , we use
S100A8 /
S100A9 imaging to predict the development of disease activity . -
pubmed
Furthermore ,
S100A8 /
S100A9 can act as a very early and sensitive biomarker in experimental
leishmaniasis for phagocyte activation linked to an effective Th1 - response . -
pubmed
In conclusion , the
alarmin S100A8 /
S100A9 is a valuable and sensitive molecular target for novel imaging approaches to monitor clinically relevant
inflammatory disorders on a molecular level . -
pubmed
Over - expression of
TLR4 -
CD14 , pro - inflammatory
cytokines , metabolic markers and NEFAs in
obese non - diabetic Mexicans . -
pubmed
The purpose of our study was to determine the levels of expression of
TLR4 - CD14 , the pro - inflammatory cytokines , the metabolic markers and the NEFAs in a group of adult ,
non - diabetic obese Mexicans . -
pubmed
RESULTS :
Obesity is strongly associated with the expression of
TLR4 ( 77 % , MFI ( Mean Fluorescence Index ) 7.70 ) and
CD14 ( 86 % MFI 1.61 ) with 66 % double positives ( p = 0.000 ) . -
pubmed
Insulin levels were 12.1 vs 19.7 mcU / ml ( p = 0.000 ) and the NEFAs were much higher in the
obese vs normal weight / thin individuals ( p = 0.000 ) . -
pubmed
A Novel
KCNJ13 Nonsense Mutation and Loss of
Kir7.1 Channel Function Causes
Leber Congenital Amaurosis (
LCA16 ) . -
pubmed
Mutations in the
KCNJ13 gene that encodes the inwardly rectifying
potassium channel
Kir7.1 cause
snowflake vitreoretinal degeneration (
SVD ) and
leber congenital amaurosis (
LCA ) . -
pubmed
Heterologous expressions of the mutant channel have suggested a dominant - negative loss of
Kir7.1 function in
SVD , but parallel studies in
LCA16 have been lacking . -
pubmed
Thus , we have extended the observation that
Kir7.1 mutations are associated with
vision disorders to include novel insights into the molecular mechanism of disease pathobiology in LCA16 . -
pubmed
The European Neuroendocrine Tumor Society ( ENETS)/Tumor Node Metastasis ( TNM ) staging system together with a grading based on the
Ki-67 proliferation index and mitotic counts has proven to give more appropriate prognostic information than the World Health Organization ( WHO)/American Joint Committee on
Cancer ( AJCC ) TNM staging but may still fail to safely differentiate benign from malignant
lesions . -
pubmed
Well- or intermediately differentiated
tumors & gt;=2 cm with imaging evidence of
malignancy or with a
Ki-67 & gt;2 % should be resected . -
pubmed
It has been suggested that
non - MEN related , nonfunctioning , and asymptomatic
PNETs & lt;2 cm with a
Ki-67 index & lt;=2 % carry a low risk of metastasis and may be observed in the absence of clinical or radiologic criteria of malignancy or progression , especially in older patients . -
pubmed
We identify
RPTPsigma , a
transmembrane tyrosine phosphatase , as a therapeutic target for
FLS - directed therapy . -
pubmed
Furthermore , administration of the
RPTPsigma decoy protein ameliorated in vivo
human FLS invasiveness and
arthritis severity in the K / BxN serum transfer model of
RA . -
pubmed
Differential Levels of
Alpha-2 - Macroglobulin ,
Haptoglobin and
Sero - Transferrin as Adjunct Markers for
TB Diagnosis and Disease Progression in the Malnourished Tribal Population of Melghat , India . -
pubmed
Three most differentially expressed proteins ;
alpha-2 - macroglobulin (
A-2 - M ) ,
sero - transferrin and
haptoglobin were identified by MALDI - TOF MS analysis , which were up - regulated in the malnourished patients with active
TB and down - regulated in the malnourished patients compared with the healthy controls . -
pubmed
Our preliminary results suggest that
A-2 - M ,
sero - transferrin and
haptoglobin may be clinically relevant host biomarkers for
TB diagnosis and disease progression in the malnourished population . -
pubmed
Akt Kinase - Interacting Protein 1 Signals through
CREB to Drive Diffuse
Malignant Mesothelioma . -
pubmed
Aki1 has been suggested as a therapeutic target , but its potential has yet to be evaluated in a
tumor setting . -
pubmed
Clinically ,
Aki1 was expressed in most
human DMM specimens where its expression correlated with phosphorylated
CREB1 . -
pubmed
Notably ,
Aki1 siRNA potently blocked
tumor growth in an orthotopic implantation model of DMM when administered directly into the pleural cavity of
tumor - bearing
mice . -
pubmed
Our findings suggest an important role for the
Aki1 -
CREB axis in
DMM pathogenesis and provide a preclinical rationale to target
Aki1 by intrathoracic therapy in locally advanced
tumors . -
pubmed
Quantitative
hepatitis B surface antigen combined with
hepatitis B e antigen as sustained virological response predictors during extended therapy with
Peginterferon alfa-2a for
hepatitis B e antigen - positive
chronic hepatitis B. -
pubmed
BACKGROUND : The best strategy for
chronic hepatitis B patients with poor response to 48 weeks of
Peginterferon - based therapy has been controversial and the predictive value of
hepatitis B surface antigen (
HBsAg ) ,
hepatitis B e antigen (
HBeAg ) and
hepatitis B virus (
HBV ) DNA levels for determining the sustained virological response ( SVR ) of these
patients is uncertain . -
pubmed
AIMS : In this study , we investigated the effects of
Bax - inhibiting peptide ( Bip)-V5 , an anti - apoptosis membrane - permeable peptide , on the
6 - hydroxydopamine (
6 - OHDA ) induced
Parkinson ' s disease (
PD ) model
rats . -
pubmed
SIGNIFICANCE : Our results provide a new idea that
Bax - inhibiting peptide may be a promising preventive or therapeutic method for
PD . -
pubmed
The hormone
islet amyloid polypeptide (
IAPP , or
amylin ) plays a role in
glucose homeostasis but aggregates to form islet amyloid in
type-2 diabetes . -
pubmed
Recent work suggests a role for
IAPP aggregation in cardiovascular complications of
type-2 diabetes and hints at a possible role in
type-1 diabetes . -
pubmed
Open questions in the field include the relative importance of the various mechanisms of beta - cell death , the relevance of reductionist biophysical studies to the situation in vivo , the molecular mechanism of amyloid formation in vitro and in vivo , the factors which trigger amyloid formation in
type-2 diabetes , the potential role of
IAPP in
type-1 diabetes , the development of clinically relevant inhibitors of
islet amyloidosis toxicity , and the design of soluble , bioactive variants of
IAPP for use as adjuncts to
insulin therapy . -
pubmed
Enhanced radiosensitivity by
DNMT3B RNAi was also observed in a
tumor xenograft model . -
pubmed
Downregulation of
DNMT3B , one of the targets identified using this method , radiosensitizes
cancer cells by disturbing multiple DNA damage responses . -
pubmed
Mutation and CNV frequencies offer insights into which genes may play
tumor suppressive or oncogenic roles , such as
NEIL2 and
RRM2B , respectively . -
pubmed
PARP-1 inhibition alleviates
diabetic cardiac complications in experimental animals . -
pubmed
We investigated the implication of
PARP-1 in
diabetic cardiac complications . -
pubmed
PARP inhibitor
4 - aminobenzamide (
4 - AB ) was administered daily for ten weeks after
diabetes induction . -
pubmed
Hearts isolated from
diabetic animals showed increased
PARP-1 enzyme activity compared to control
animals while significantly reduced by 4 - AB administration . -
pubmed
PARP-1 inhibition by
4 - AB alleviated
cardiac ischemia in
diabetic animals as indicated by ECG changes . -
pubmed
PARP-1 inhibition also reduced
cardiac inflammation in
diabetic animals as evidenced by histopathological changes . -
pubmed
Moreover ,
PARP-1 inhibition decreased serum levels of
TNF - alpha and cardiac
nitrite but increased cardiac
GSH contents in
diabetic animals . -
pubmed
However ,
PARP-1 inhibition did not significantly affect the developed
hyperglycemia . -
pubmed
Our findings prove that
PARP-1 enzyme plays an important role in
diabetic cardiac complications through combining
inflammation , oxidative stress , and
fibrosis mechanisms . -
pubmed
Mo polyoxometalate nanoparticles inhibit
tumor growth and
vascular endothelial growth factor induced angiogenesis . -
pubmed
After a single
muscle injury ,
C / EBPbeta - deficient satellite cells fail to self - renew resulting in a reduction of satellite cells available for future rounds of regeneration . -
pubmed
LTB - Syn : a recombinant immunogen for the development of plant - made vaccines against
synucleinopathies . -
pubmed
Synucleinopathies are
neurodegenerative diseases characterized by the abnormal accumulation of
alpha - synuclein (
alpha - Syn , a 140 amino acid protein that normally plays various neurophysiologic roles ) aggregates . -
pubmed
Parkinson ' s disease (
PD ) is the
synucleinopathy with the highest epidemiologic impact and although its etiology remains unknown ,
alpha - Syn aggregation during disease progression pointed out
alpha - Syn as target in the development of immunotherapies . -
pubmed
Our results suggest that dietary soy ameliorates adiposity ,
insulin sensitivity ,
adipose tissue inflammation , and arterial stiffness and exerts a beneficial shift in gut microbial communities in a
rat model that mimics
human menopause . -
pubmed
Taken together , our results indicated that
SAA suppressed
c - met expression and enhanced the sensitivity of
lung adenocarcinoma A549 cells to
cisplatin through
AKT /
mTOR signaling pathway . -
pubmed
RESULTS : Serum
Se and
SELENOP concentrations were relatively low in both control and
AITD women . -
pubmed
From first to third trimester ,
TPO - aAb and
TG - aAb declined in
AITD by 71 % and 60 % , respectively . -
pubmed
T cell trafficking into
tumors depends on a " match " between
chemokine receptors on effector cells ( e.g. -
pubmed
There is often a
chemokine /
chemokine receptor " mismatch " , with
tumors producing minute amounts of
chemokines , resulting in inefficient targeting of effectors to
tumors . -
pubmed
We aimed to alter
tumors to produce higher levels of
CXCL11 , a
CXCR3 ligand , to attract more effector cells following immunotherapy . -
pubmed
In our first approach , we used modified
chimeric antigen receptor ( CAR )- transduced human T cells to deliver
CXCL11 (
CAR /
CXCL11 ) into
tumors . -
pubmed
CAR /
CXCL11 and
VV.CXCL11 significantly increased
CXCL11 protein levels within
tumors . -
pubmed
Both approaches were successful in increasing
CXCL11 levels within the
tumors ; however , only the vaccinia approach was successful in recruiting T cells and augmenting anti - tumor efficacy . -
pubmed
Tempol , a
superoxide dismutase mimetic agent , reduces
cisplatin - induced
nephrotoxicity in
rats . -
pubmed
This study is aimed to evaluate the role of a
super oxide dismutase (
SOD ) mimetic agent ,
tempol , in protection against CP
nephrotoxicity in
rats . -
pubmed
Tempol also significantly decreased kidney
caspase-3 expression which was elevated by CP
toxicity . -
pubmed
[
Indoleamine 2,3 - Dioxygenase Activity during Long - Term
Letrozole Therapy for
Hormone Receptor - Positive
Breast Cancer ] . -
pubmed
Endocrine therapy is effective for elderly
patients who are diagnosed with
estrogen receptor - positive
breast cancer and can not receive surgical treatment or chemotherapy because of advanced age . -
pubmed
Based on previous research , individuals who had lower income , lower educational levels , or
type 2 diabetes ; who were African American or Hispanic , uninsured , or not using
insulin or oral medication for
diabetes ; or who did not have DR were defined as being at high risk of missing recommended eye examinations . -
pubmed
[ Correlation of
EBV Infection with Expression of
TNF - alpha - Inducing Protein 3 Gene and
A20 Protein in Hodgkin 's Lmphoma ] . -
pubmed
OBJECTIVE : To analyze the correlation of
EBV infection with expression of
TNF - alpha - inducing protein 3 gene and
A20 protein in
Hodgkin lmphoma . -
pubmed
Correlation analysis showed that
EBV infection did not significantly relate with expression loss of
A20 protein and the gene deletion of
TNF - alpha inducing protein 3 ( P>0.05 ) . -
pubmed
CONCLUSION : The expression loss of
A20 protein and gene detection of
TNFalpha inducing protein 3 are found in both
EBV negative and positive
patients with
Hodgkin ' s lymphoma , however the results of immunohistochemical staining and fluorescence in situ hybridization are not complete consistant , the reason may closely relate with the technical factors . -
pubmed
Identification and Characterization of Known Biallelic Mutations in the
IFT27 (
BBS19 ) Gene in a Novel Family With
Bardet - Biedl Syndrome . -
pubmed
We report a family with typical
BBS features (
retinitis pigmentosa ,
postaxial polydactyly ,
obesity ,
cognitive impairment , and
atrioventricular septal defect ) mutated in
IFT27 /
BBS19 . -
pubmed
This is the third report of
IFT27 mutations in
BBS patients confirming
IFT27 as a
BBS gene (
BBS19 ) . -
pubmed
Mutations in
IFT genes (
IFT27 ,
IFT172 and
IFT74 ) confirm the
IFT - pathway as a pathomechanism for
BBS . -
pubmed
Obtained data clarify peripheral effects that occur during activation of the
I1Rs under endogenous catecholaminergic stress , and can be used in clinical practice for more precise control of heart contractility in some
cardiovascular pathologies . -
pubmed
Cytomegalovirus (
CMV ) has emerged as an immunologic target in
GBM given that
tumor cells have been shown to express the
CMV - associated proteins IE1 and
pp65 . -
pubmed
As the
patient 's
tumor stained positive for
CMV antigens
IE1 and
pp65 , it is hypothesized that she developed an immune response against
CMV during recovery that contributed to anti -
tumor surveillance and prolonged survival . -
pubmed
Avagacestat , a
gamma ( gamma )- secretase inhibitor that was in development for treatment of
Alzheimer ' s disease , produced
ovarian granulosa - thecal cell tumors in
rats and
dogs and a
glomerulopathy with profound
proteinuria in female
rats . -
pubmed
Ovarian proliferative changes in
rats likely resulted from : 1 ) inhibition of Notch signaling pathways regulating ovarian follicular differentiation / development , characterized microscopically as altered ovarian cyclicity and/or ovarian follicular degeneration ; 2 ) subsequent disruption of the hypothalamic - pituitary - ovarian axis due to ovarian
atrophy with decreases in serum
estrogen and
progesterone ( as low as 0.45x and 0.21x controls , respectively ) ; and 3 ) chronic
gonadotropin stimulation and
pituitary hypertrophy /
hyperplasia in response to the absence of negative feedback . -
pubmed
In contrast ,
adrenocortical hypertrophy in female
rats was considered secondary to ovarian changes based on the absence of this finding in
avagacestat - treated OVX
rats and no increase in
ACTH staining in the pituitary . -
pubmed
In addition , the expression of
prostaglandin E2 receptor 4 (
EP4 ) was decreased in
cardiac fibrosis . -
pubmed
In vivo lnc000908 silencing by lentivirus increased the
EP4 level , decreased endothelial - mesenchymal transition ( EndMT ) and improved
cardiac fibrosis and cardiac function . -
pubmed
This study demonstrates that lnc000908 is a novel regulator of
cardiac fibrosis by modulating the
EP4 expression and
EndMT . -
pubmed
Mutation of
CEP72 Gene May Predispose Patients to
Hepatotoxicity . -
pubmed
Polymorphisms in
CEP72 have been linked to increased incidence of
vincristine - induced
toxicities , namely
peripheral neuropathy . -
pubmed
This report describes
hepatotoxicity that first developed during consolidation in a
patient homozygous for the
CEP72 risk alleles . -
pubmed
RESULTS : Results indicate that
C3948 cell line has a histological phenotype representative of original
ATC cells and a completely aberrant karyotype with many chromosomal losses and gains ; harbors mutated
TP53 ,
STK11 , and
DIS3L2 genes ; presents a gene expression profile similar to
C643 ATC commercial cell line , but with some unique alterations ; has a doubling time similar to
C643 ; and the IC50 profile for
paclitaxel ,
doxorubicin , and
cisplatin is similar to
C643 , although higher for
cisplatin . -
pubmed
After radiolabeling the immunoconjugates with
zirconium-89 , we conducted PET imaging and biodistribution studies in two different
mouse models of
HER2 - expressing
breast cancer . -
pubmed
ImmunoPET and biodistribution experiments in athymic
nude mice bearing
HER2 - expressing
BT474 human breast cancer xenografts yielded no significant differences in the in vivo behavior of the radioimmunoconjugates . -
pubmed
Yet experiments in
tumor - bearing humanized
NSG mice revealed that 89Zr - DFO - sspertuzumab - EndoS produces higher activity concentrations in the
tumor ( 111.8 + - 39.9 % ID / g ) and lower activity concentrations in the liver and spleen ( 4.7 + - 0.8 % ID / g and 13.1 + - 4.0 % ID / g , respectively ) than its non - site - specifically labeled cousin , a phenomenon we believe stems from the altered binding of the former to
huFcgammaRI . -
pubmed
Genome - wide identification of antimicrobial peptide genes (
AMPs ) and their expression in response to
fungal infection was performed in the resistant
cassava cultivar ( Huay Bong 60 ; HB60 ) in comparison with the highly susceptible cultivar ( Hanatee ; HN ) . -
pubmed
Altogether , these findings suggest that
snakins have a potential function in the
CAD defense response in
cassava . -
pubmed
Suppression of
sirtuin 1 alleviates
airway inflammation through
mTOR - mediated autophagy . -
pubmed
Sirtuin 1 (
SIRT1 ) is involved in the pathogenesis of
allergic asthma . -
pubmed
This study aimed to investigate whether
EX-527 , a specific
SIRT1 inhibitor , exerted suppressive effects on
allergic airway inflammation in
mice submitted to
ovalbumin ( OVA ) inhalation . -
pubmed
The study found that
EX-527 reversed OVA - induced
airway inflammation , and reduced OVA - induced increases in inflammatory
cytokine expression , and total cell and eosinophil counts in bronchoalveolar lavage fluid . -
pubmed
To assess whether
EX-527 inhibited
airway inflammation in
asthma through the
mTOR - mediated autophagy pathway ,
rapamycin was administered to
mice treated with
EX-527 after OVA sensitization . -
pubmed
Taken together , the present findings indicated that
EX-527 may inhibit
allergic airway inflammation by suppressing autophagy , an effect mediated by
mTOR activation in allergic
mice . -
pubmed
We focused on eight draggable genes for
BTC , which were described as having evidence of therapeutic impact ( evidence level 2A-3B ) based on the clinical practice guidance for next - generation sequencing in
cancer diagnosis and treatment ; these include
ERBB2 ,
NTRK1 ,
RNF43 ,
CDK6 ,
CDKN2B ,
FGFR2 ,
IDH1 , and
IDH2 . -
pubmed
Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the
P301S Mouse Model of
Tauopathy : Implications for Early Diagnosis and Translational Research in
Alzheimer ' s Disease . -
pubmed
RESULTS : Neutrophil , platelet , and monocyte counts , as well as
NLR , PLR , and
MLR values were higher in the
manic episodes of
bipolar disorder compared to the control group . -
pubmed
Decreased neutrophil and lymphocyte counts , and decreased
NLR ,
PLR , and MLR were observed in the remission period after - treatment of the
manic bipolar disorder episodes . -
pubmed
CONCLUSIONS : The study indicates that NLR and PLR may be used as state markers and that
MLR may be used as a trait marker in
bipolar disorder . -
pubmed
Aberrant
NSUN2 - mediated m5C modification of
H19 lncRNA is associated with poor differentiation of
hepatocellular carcinoma . -
pubmed
Studies have shown that the expression of
H19 lncRNA is abnormally elevated and has a carcinogenic effect in many types of
tumors . -
pubmed
Besides , both the m5C methylation level and the expression level of
H19 lncRNA in hepatocellular
carcinoma tissues were significantly higher than those in adjacent
non - cancer tissues , which were closely associated with poor differentiation of
hepatocellular carcinoma (
HCC ) . -
pubmed
The m5C - modified
H19 lncRNA may promote the occurrence and development of
tumors by recruiting the
G3BP1 oncoprotein . -
pubmed
Inhibiting the
Pkm2 /
b - catenin axis drives in vivo replication of adult cardiomyocytes following experimental
MI . -
pubmed
While expression of muscle
pyruvate kinase 2 (
Pkm2 ) , a cytosolic enzyme catalyzing the final step in glycolysis , is high in
end - stage heart failure (
HF ) , the loss of
Pkm2 promotes proliferation in some cellular systems , in vivo . -
pubmed
Thus , we investigated the potential for
Pkm2 to regulate CM proliferation in a
mouse model of
myocardial infarction (
MI ) employing inducible , cardiac - specific
Pkm2 gene knockout (
Pkm2KOi )
mice . -
pubmed
We found a lack of
cardiac hypertrophy or expression of the fetal gene program in
Pkm2KOi mice post
MI , as compared to vehicle control
animals ( P < 0.01 ) , correlating with smaller
infarct size , improved mitochondrial ( mt ) function , enhanced angiogenesis , reduced degree of CM apoptosis , and reduced oxidative stress post
MI . -
pubmed
Collectively , this work supports a novel antiproliferative function for
Pkm2 in
CM through the sequestration of
Ctnnb1 in the cytoplasm of
CM whereas loss of
Pkm2 is essential for CM proliferation . -
pubmed
Reducing cardiac
Pkm2 expression may provide a useful strategy for cardiac repair after
MI in
patients . -
pubmed
Impact of
hypoxia and
AMPK on
CFTR - mediated
bicarbonate secretion in
human cholangiocyte organoids . -
pubmed
BACKGROUND AND AIMS : Cholangiocytes express
cystic fibrosis transmembrane conductance regulator (
CFTR ) which is involved in
bicarbonate secretion for the protection against
bile toxicity . -
pubmed
Hypoxia is known to diminish
CFTR activity in the intestine , but whether it effects
CFTR activity in cholangiocytes remains unknown . -
pubmed
Thus , the aim of this study is to investigate the effect of
hypoxia on
CFTR activity in intrahepatic cholangiocyte organoids ( ICOs ) and test drug - interventions to restore
bicarbonate secretion . -
pubmed
During
hypoxia ,
CFTR activity significantly decreased ( p=0.01 ) . -
pubmed
Switching from
oxygen to
hypoxia during
CFTR - measurements , reduced
CFTR activity ( p=0.03 ) . -
pubmed
Importantly , addition of
AMPK - inhibitor restored
CFTR - mediated anion - secretion during
hypoxia . -
pubmed
Response of plasma
insulin to small doses of
tolbutamide in
obesity and
acromegaly . -
pubmed
The early response of plasma
insulin ( IRI ) to successive intravenous doses of 50 , 100 and 200 mg of
tolbutamide was studied in nondiabetic
obese subjects , in
acromegalic patients , and in healthy controls . -
pubmed
The
insulin response was correlated with the basal IRI in controls and in obese
subjects but not in
acromegalic patients . -
pubmed
The results suggest that in
obesity the stimulus - secretion coupling of
insulin output is normal but the number of secretory units is increased . -
pubmed
In
acromegaly the
insulin release pattern is compatible with an increased number of secretory units which , however , are relatively insensitive to
tolbutamide , probably due to an elevated
serum growth hormone level . -
pubmed
[
Juvenile optic neuropathy caused by Km variants of
biotinidase ] . -
pubmed
Bone abnormalities included abnormal cartilage - bone transition at the growth plate , general bone matrix disorganization due to irregularly oriented bundles of
collagen , mineral crystals on the osteocyte lacunar rim , and accumulations of thickened collagen fibrils , also along the osteocyte lacunar rim . -
pubmed
The most likely explanation is that a factor , or factors , cause the inhibition of release of
lymphokines which thereby have a suppressive effect on
rheumatoid inflammation . -
pubmed
Injury induces increase of
von Willebrand factor in
rat endothelial cells . -
pubmed
Endothelial cells from normal , endotoxin - treated , and
balloon - injured rats were stained with
vWF antibodies and visualized using a biotinylated secondary antibody and avidin - tagged peroxidase . -
pubmed
Endotoxin treatment and
balloon injury caused a threefold increase in intracellular
vWF , and immunoelectron microscopy showed the endoplasmic reticulum to stain heavily by the
vWF antibody . -
pubmed
These results suggest that
endothelial injury leads to an increased intracellular content of
vWF that is localized primarily in the endoplasmic reticulum . -
pubmed
Univariate analysis showed that female sex , normal performance status , well - differentiated
tumor , and curative resection were associated with increased survival ;
cholangiocarcinoma , nodal metastases ,
cirrhosis ,
hypocalcemia , prolonged
prothrombin time , and increased
serum transaminase and
alkaline phosphatase were associated with decreased survival . -
pubmed
Cox multivariate analysis showed that curative resection , normal performance status , and well - differentiated
tumors were associated with increased survival , and prolonged
prothrombin time and
hypocalcemia were associated with decreased survival . -
pubmed
[
Hormone receptor determination in
breast cancer using the dextran- coated
charcoal method and monoclonal antibodies : correlation with cytomorphologic grading ] . -
pubmed
In 129 cases , results from
ER - ICA (
Estrogen receptor immunocytochemical assay ) applied to
breast carcinoma biopsy smears and results from
ER - EIA (
Estrogen receptor enzyme immunoassay ) applied to cytosols of breast
carcinoma were compared to the results of
ER(DCC ) ,
PR(DCC ) and a cytomorphological grading . -
pubmed
There is a relation between the visual nuclear grade from the Pappenheim stained specimens and
ER - ICA and
ER - EIA . -
pubmed
Our present data show clearly that there is a closer correlation of cytomorphology with
ER - EIA than with
ER(
DCC ) and
PR(DCC ) . -
pubmed
Cell lines derived from some
thymic lymphomas presented a very immature phenotype and did not express cellular markers of either T - cells ( Thy 1.2 , Lyt 1.2 , and Lyt 2.2 ) or B - cells ( cytoplasmic
IgM ) even after treatment with several differentiation inducers . -
pubmed
Safer
proteinase treatment of
sciatica . -
pubmed
Induction of specific immunity to
human colon carcinoma by anti - idiotypic antibodies to
monoclonal antibody CO17 - 1A. -
pubmed
Anti - idiotypic antibodies (
Ab2 ) to
murine monoclonal antibody ( mAb ) CO17 - 1A (
Ab1 ) , which defines an antigen associated with
human colon carcinoma , were produced in
goats . -
pubmed
The
Ab2 inhibited binding of
Ab1 to
colon carcinoma cells , and purified
tumor antigen inhibited binding of
Ab1 to
Ab2 . -
pubmed
Moreover , both
Ab1 and
Ab3 bound to the isolated
tumor antigen , and the
Ab3 lysed
human colon carcinoma cells in culture in the presence of
rabbit complement . -
pubmed
Thus ,
Ab2 raised to
mAb CO17 - 1A are candidates for use in immunotherapy trials in
cancer patients . -
pubmed
Expression of
Ca antigen on
human urinary bladder tumors . -
pubmed
Flow cytometric measurements of
Ca antigen (
Ca ) visualized by immunofluorescence with Ca1 monoclonal antibody ( Ca1 ) were performed on cells from 26
urinary bladder carcinomas of various histologic grades and DNA ploidy and on 6 samples of morphologically
normal urothelium . -
pubmed
Urinary
kallikrein activity , renal hemodynamics , and electrolyte handling during chronic beta blockade with
propranolol in
hypertension . -
pubmed
Diurnal patterns of serum immunoreactive
calcitonin in healthy
males and in
insulin dependent diabetics . -
pubmed
Serum immunoreactive
calcitonin (
iCT ) was measured half - hourly for 27 h in five healthy
males and four
insulin dependent juvenile
diabetic males during normal activity . -
pubmed
Anti - TFB immunity was studied in the recipients either by looking for the apparition of
cutaneous lesions after superinfection by TFB , or by counting of
Listeria monocytogenes remaining in the liver and in the spleen 48 h after a mixture of TFB and
L. - pubmed
These tests are based on acute dosing of
mice and various blood or serum measurements : ( a ) total white blood cell count for
leukopenia ; ( b ) BUN for
kidney toxicity ; ( c ) SGPT for
liver toxicity ; and ( d )
creatine phosphokinase MB isozyme (
CPK - MB ) for
cardiotoxicity . -
pubmed
The
factor VIII gene has been cloned in 1984 and a large number of mutations that cause
hemophilia A have been identified in the last decade . -
pubmed
The most common of the mutations is an inversion of
factor VIII that accounts for nearly 45 % of patients with severe
hemophilia A. -
pubmed
MDM2 and
CDK4 gene amplification in
Ewing ' s sarcoma . -
pubmed
Amplification of the
MDM2 gene , which maps to chromosome band 12q13 and encodes a
p53 - binding protein , may result in functional inactivation of
p53 and has been observed in various
bone and soft tissue sarcomas . -
pubmed
Published studies have included few cases of
Ewing ' s sarcoma (
ES ) or
peripheral neuroectodermal tumour (
PNET ) , a
tumour group in which alterations of the
p53 pathway have so far not been extensively studied . -
pubmed
We examined two
ES cell lines ,
RD - ES and
SK - ES-1 , and 30 specimens from 27
patients ( 24
ES , 6
PNET ; 19 primary , 4 local recurrence , 7 metastasis ) for
MDM2 gene amplification by Southern blot analysis . -
pubmed
All 30 clinical specimens had been confirmed to contain sufficient ES /
PNET DNA by the demonstration of a rearrangement of the t(11;22)-associated
EWS gene using an
EWS cDNA probe on the same blots . -
pubmed
MDM2 gene amplification was detected in 3 of 30 specimens ( 10 per cent ) , including two
ES and one
PNET , but in neither of the cell lines . -
pubmed
Insulin secretion in obese and non - obese
women with
polycystic ovary syndrome and its relationship with
hyperandrogenism . -
pubmed
Glucose ,
insulin ,
androstenedione and
testosterone levels were determined and the blood
glucose and
insulin response of
women with
PCO and normal
women were compared . -
pubmed
Affinity selection of a 15 - mer random peptide library displayed on
bacteriophage M13 has been used to identify potent ligands for the
human urokinase receptor , a key mediator of
tumor cell invasion . -
pubmed
Interleukin-6 ,
neutrophilia and the acute phase protein response in
colorectal cancer patients . -
pubmed
White blood cell counts and circulating
interleukin-6 concentrations were measured in male
colorectal cancer patients with ( n = 12 ) and without ( n = 15 ) evidence of an acute phase protein response . -
pubmed
These results suggest that in
colorectal cancer patients although an acute phase protein response is associated with
neutrophilia , both events can occur independent of circulating
interleukin-6 concentrations . -
pubmed
Expression of
histamine receptors in different cell lines derived from mammary gland and
human breast carcinomas . -
pubmed
Epidermal growth factor receptor immunoreactivity in
gallbladder and extrahepatic biliary tract tumours . -
pubmed
Elevated levels of
epidermal growth factor receptor (
EGFR ) , a transmembrane
protein tyrosine kinase receptor , are found in
carcinomas from various sites of the body . -
pubmed
We investigated the expression of
EGFR in
carcinoma of the gallbladder ( n = 13 ) , common bile duct ( n = 7 ) and ampulla of Vater ( n = 9 ) . -
pubmed
In conclusion ,
EGFR expression is increased in both gallbladder , common bile duct and ampullary
carcinomas but not in non - malignant conditions of the gallbladder and biliary tract . -
pubmed
These findings suggest that
EGFR overexpression occurs late in the sequential development of
gallbladder and biliary tract cancers . -
pubmed
Serum levels of
squamous cell carcinoma antigen and
carcinoembryonic antigen as
tumor markers of
vulvar cancer . -
pubmed
OBJECTIVE : To assess whether
squamous cell carcinoma (
SCC ) antigen and
carcinoembryonic antigen (
CEA ) are useful as
tumor markers of
vulvar cancer . -
pubmed
METHODS : The serum levels of
SCC antigen and
CEA were determined for 30
patients with invasive
vulvar carcinoma . -
pubmed
Human gastric lipase (
HGL ;
triacylglycerol lipase ;
EC 3.1.1.3 ) plays an important role in the digestion of dietary
triglycerides in the gastrointestinal tract , especially in
patients suffering from
pancreatic lipase deficiencies . -
pubmed
The
HGL and
RLL gene organizations are identical , suggesting that
RLL is the
rat gastric lipase expressed in the
serous von Ebner glands of the tongue . -
pubmed
The neurotrophic factors
ciliary neurotrophic factor and
brain - derived neurotrophic factor can prevent motor neuron cell death during development and after
nerve lesion in neonatal
rodents . -
pubmed
This way of delivery corresponds to the physiological situation in adult
rodents , under which endogenous
CNTF is present in the cytosol of Schwann cells and
BDNF expression is upregulated after
nerve lesion , making these factors available to the damaged motor neurons . -
pubmed
Recent results show that overexpression of muscle - derived
neurotrophin-3 prevents degeneration of axons and motor endplates , but has only little effect on the number of motor neuron cell bodies in a
murine animal model of
motor neuron disease . -
pubmed
We now hypothesize that these factors also regulate
PMN surface integrins , that regulation of
UC PMNs is different than that of control PMNs , and that the
integrin regulation is consistent with the ROS regulation . -
pubmed
In contrast , rectal dialysates failed to up - regulate
CD11b of inactive
UC PMNs and in fact down - regulated
CD11b . -
pubmed
Transforming growth factor - beta stimulates
urokinase expression in
tumor - associated macrophages of the breast . -
pubmed
Recent studies have shown that
urokinase (
uPA ) is an independent prognostic marker in
breast cancer . -
pubmed
uPA plays a key role in the degradation of
tumor matrix and promotes
tumor progression . -
pubmed
Our objective in the present study was to provide evidence that
tumor growth factor - beta (
TGF - beta ) released from
breast cancer cells markedly up - regulates
uPA expression in
tumor - associated macrophages ( TAMs ) . -
pubmed
We reported previously that B16,JB / RH and
JB / MS melanomas of C57BL/6
mice express the common melanoma - associated antigen (
MAA ) recognized by MM2 - 9B6 monoclonal antibody (
MAb ) . -
pubmed
Southern blot analysis of EcoRI- and
HindIII - digested DNAs from these
melanomas showed several retroviral insertion sites . -
pubmed
Our data indicate that
c - maf is a common insertion site of MelARV in BL6 ,
Meli - A1 and
Meli - BL melanomas , whereas no such insertion site was found in the melanocytes infected with MelARV but not malignantly transformed . -
pubmed
Recently , leukocytapheresis and massive
immunoglobulin 7S treatment are available for the treatment of
ulcerative colitis . -
pubmed
HTLV-1 - infected subjects also had poor
interleukin ( IL )- 4 responses to mitogenic stimulation , unlike persons without
HTLV-1 infection . -
pubmed
The impaired
IgE responses and other effects of
IL-4 down - regulation may be contributing factors to more severe disease and impaired response to treatment of
strongyloidiasis in some
HTLV-1 - infected persons . -
pubmed
Growth factors , especially
interleukin-6 , appear to be critical for disease progression , and interruption of autocrine and paracrine loops has been achieved with resultant inhibition of
myeloma cell growth . -
pubmed
A potential role for B / macrophage cells in
inflammation was shown by their ability to express
prostaglandin H synthase-1 (
COX-1 ) and
prostaglandin H synthase-2 (
COX-2 ) and by their production of
prostaglandin ( PG ) E ( 2 ) . -
pubmed
In contrast ,
COX-2 and the
prostanoids PGE ( 2 ) ,
PGF ( 2alpha ) and
PGD ( 2 ) are highly inducible in B/ macrophage cells upon stimulation with lipopolysaccharide ,
CD40 ligand , or via engagement of
surface IgM , supporting a role for these cells in
inflammation . -
pubmed
Human activin - A is expressed in the
atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells . -
pubmed
In this study , we investigated the role of
activin in the initiation and progression of
human atherosclerosis . -
pubmed
We developed an " in situ free -
activin binding assay " by using biotinylated
follistatin , which allowed us to detect bioactive
activin at specific sites in
atherosclerotic lesions . -
pubmed
The mRNAs encoding the
activin receptors are expressed similarly in normal and
atherosclerotic tissue , which indicates that
activin - A signaling in atherogenesis is most likely dependent on changes in growth factor concentrations rather than on receptor levels . -
pubmed
Endocrine studies in cases 1 - 4 and 6 showed that cases 1 , 3 , and 6 had definite
primary hypogonadism , with basal
FSH levels of 54 , 39 , and 41 IU / L , respectively , whereas case 2 with severe
malnutrition was unremarkable for the baseline values , and case 4 had fairly good testicular function . -
pubmed
Sequence analysis in cases 1 - 4 and 6 showed that they had normal sequences of each exon of
DMRT1 and the
DM domain of
DMRT2 on the normal chromosome 9 , and that cases 1 - 4 had normal
SRY sequence . -
pubmed
The glomerular filtration rate , urinary
zinc excretion ,
zinc clearance ,
zinc clearance /
creatinine clearance ratio ,
zinc tubular reabsorption ,
glycosuria , plasma
glucose ,
C - peptide , glucagon , and
cortisol were investigated in 10 normal
individuals ( Group C1 and Group C2 , respectively ) and 10
IDDM patients ( Group E1 :
hyperglycemic and glycosuric and Group E2 : normoglycemic and aglycosuric ) during placebo or venous
zinc tolerance test . -
pubmed
Results revealed that 8.1
AH is associated with a high in vivo and in vitro production of
TNF - alpha , which in turn seems responsible for increased serum levels of
sELAM-1 ,
cortisol , and
IL-10 . -
pubmed
In conclusion , the increased spontaneous release of
TNF - alpha , which modifies a certain number of immunologic parameters , may be the most characterizing feature of 8.1
AH . -
pubmed
Tax , the
human T cell leukemia virus type I oncoprotein , plays a crucial role in viral transformation and the development of the
virally associated disease
adult T cell leukemia . -
pubmed
Tax - associated acceleration of cell cycle progression may play a role in the ability of this viral oncoprotein to mediate cellular transformation and promote the development of
human T cell leukemia virus type I - associated diseases . -
pubmed
Mutations in the genes of
hematopoietic growth factor receptors as a cause of
congenital cytopenia , such as
congenital amegakaryocytic thrombocytopenia (
CAMT ) or severe
congenital neutropenia (
CN ) , are discussed . -
pubmed
In
patients with
CAMT , we found inherited mutations in
c - mpl , the gene coding for the
thrombopoietin receptor , in 8 out of 8 cases . -
pubmed
Functional studies demonstrated defective
thrombopoietin (
TPO ) reactivity in hematopoietic progenitor cells and platelets in
CAMT patients . -
pubmed
CAMT is caused by inherited mutations in
c - mpl , the gene for the
thrombopoietin receptor , which lead to reduced or absent reactivity to
TPO . -
pubmed
In contrast , mutations in the
G - CSF receptor in
CN are acquired and are most probably connected with progression of the
neutropenia into
MDS /
leukemia as a result of a loss of differentiation signaling . -
pubmed
A naturally occurring mutation ( A1924 T ) in the IQ domain altered
hH1 function in a manner characteristic of the
Brugada arrhythmia syndrome , but at the same time inhibited slow inactivation induced by
Ca2 +/CaM , yielding a clinically benign (
arrhythmia free ) phenotype . -
pubmed
The objective of this study was to evaluate regeneration of alveolar bone and cementum , and associated root resorption and
ankylosis following surgical implantation of
rhBMP-2 / ACS in a
canine clinical model . -
pubmed
rhBMP-2 / ACS did not appear to be associated with aberrant healing events such as
root resorption and
ankylosis under these simulated clinical conditions . -
pubmed
CONCLUSIONS : Surgical implantation of
rhBMP-2 / ACS may be used safely to support regeneration of alveolar bone in intrabony
periodontal defects in
dogs without aberrant events such as
root resorption or
ankylosis complicating the regenerative procedure . -
pubmed
A 51 - year - old Japanese
man diagnosed with
CML was treated with
interferon - alpha . -
pubmed
This case suggests that
interferon - alpha plus
cytarabine ocfosfate therapy may be of benefit in the treatment of extramedullary blast crisis of
CML . -
pubmed
Patient 's age , sex , renal diagnosis ,
diabetes mellitus , time on dialysis , dialysis adequacy ,
erythropoietin dose ,
hepatitis C or body weight did not affect response rates . -
pubmed
The value of low dose ( 1 microg )
ACTH stimulation test in the investigation of
non - classic adrenal hyperplasia due to
11beta - hydroxylase deficiency . -
pubmed
Our aim was to investigate the responses of
11 - deoxycortisol to 1microg
ACTH ( LDT ) test in
women with
NCAH due to
11 - beta hydroxylase ( 11 - beta OH ) deficiency and to compare them with the values obtained after SDT in the
patients and in the control
subjects . -
pubmed
RESULTS : Peak
hyperleptinemia occurred after 16 hours of HC infusion ; peak / baseline
leptin levels were 129 % ( placebo ) , 140 % ( 30 mg of HC for 24 hours , p = 0.05 ) , and 185 % ( 100 mg of HC for 24 hours , p & lt ; 0.01 ) . -
pubmed
The Eleven
Lysine - rich Leukemia (
ELL ) gene undergoes translocation and fuses in frame to the
Multiple Lineage Leukemia ( MLL ) gene in a substantial proportion of
patients suffering from
acute forms of leukemia . -
pubmed
Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of
metastatic bone disease . -
pubmed
Recently , we reported that elevated levels of
IL-8 , but not
parathyroid hormone - related protein (
PTHrP ) , correlated with increased bone metastasis in a population of
human breast cancer cells . -
pubmed
We hypothesized that
IL-8 expression by
breast cancer cells would either indirectly influence osteoclastogenesis via nearby stromal cells or directly influence osteoclast differentiation and activity . -
pubmed
In the present study , we investigated the role of
IL-8 in the process of osteoclast formation and bone resorption , which is associated with metastatic
breast cancer . -
pubmed
Together , these data implicate
IL-8 in the
osteolysis associated with metastatic
breast cancer . -
pubmed
[ Role of
macroglobulins in
chronic active arthritis ] . -
pubmed
Frequent
HIN-1 promoter methylation and lack of expression in multiple human
tumor types . -
pubmed
HIN-1 ( high in normal-1 ) is a candidate
tumor suppressor identified as a gene silenced by methylation in the majority of breast
carcinomas . -
pubmed
To determine if , similar to
breast carcinomas ,
HIN-1 is also silenced in
tumors originating from other organs with high
HIN-1 expression , we analyzed its expression and promoter methylation status in lung , prostate , and
pancreatic carcinomas . -
pubmed
Nearly all prostate and a significant fraction of lung and pancreatic
carcinomas showed
HIN-1 hypermethylation , and the majority of lung and prostate
tumors lacked
HIN-1 expression . -
pubmed
In lung
carcinomas , the degree of
HIN-1 methylation differed among
tumor subtypes ( P = 0.02 ) , with the highest level of
HIN-1 methylation observed in
squamous cell carcinomas and the lowest in
small cell lung cancer . -
pubmed
In
lung adenocarcinomas , the expression of
HIN-1 correlated with cellular differentiation status . -
pubmed
Hypermethylation of the
HIN-1 promoter was also frequently observed in
normal tissue adjacent to
tumors but not in
normal tissue from
noncancer patients , implying that
HIN-1 promoter methylation may be a marker of premalignant changes . -
pubmed
Thus , silencing of
HIN-1 expression and methylation of its promoter occurs in multiple human
cancer types , suggesting that elimination of
HIN-1 function may contribute to several forms of epithelial tumorigenesis . -
pubmed
The role of
RAS oncogene in survival of patients with
lung cancer : a systematic review of the literature with meta - analysis . -
pubmed
The proto - oncogene
RAS , coding for a 21 kDa protein (
p21 ) , is mutated in 20 % of
lung cancer . -
pubmed
Published studies on
lung cancer assessing prognostic value of
RAS mutation or
p21 overexpression on survival were identified by an electronic search . -
pubmed
The combined HR was 1.35 ( 95 % CI : 1.16 - 1.56 ) , showing a worse survival for
NSCLC with
KRAS2 mutations or
p21 overexpression and , particularly , in
adenocarcinomas ( ADC ) ( HR 1.59 ; 95 % CI 1.26 - 2.02 ) and in studies using PCR ( HR 1.40 ; 95 % CI 1.18 - 1.65 ) but not in studies using IHC ( HR 1.08 ; 95 % CI 0.86 - 1.34 ) . -
pubmed
RAS appears to be a pejorative prognostic factor in terms of survival in
NSCLC globally , in
ADC and when it is studied by PCR . -
pubmed
On the basis of hypothesis that chronic UVR may modulate differentiation as well as
epidermal hyperplasia , we evaluated the modulation of markers of epidermal differentiation , such as
transglutaminase 1 (
TGase 1 ) ,
filaggrin and
loricrin , by chronic UVR in vivo . -
pubmed
Targeting the
platelet - derived growth factor receptor alpha with a neutralizing
human monoclonal antibody inhibits the growth of
tumor xenografts : implications as a potential therapeutic target . -
pubmed
Platelet - derived growth factor receptor alpha (
PDGFRalpha ) is a
type III receptor tyrosine kinase that is expressed on a variety of
tumor types . -
pubmed
This inhibition was seen in both transfected and
tumor cell lines expressing
PDGFRalpha . -
pubmed
These data suggest that 3G3 may be useful for the treatment of
tumors that express
PDGFRalpha . -
pubmed
Neurosteroids are potent blockers of
neuronal low - voltage activated ( T - type ) Ca ( 2 + ) channels and potentiators of
GABA ( A ) ligand - gated channels , but their effects in peripheral
pain pathways have not been studied previously . -
pubmed
These results strongly suggest that
GABA ( A ) channels do not contribute to baseline
pain transmission , but they can enhance anti - nociception mediated by blockade of
T - type Ca ( 2 + ) channels . -
pubmed
Proliferative signaling by
store - operated calcium channels opposes
colon cancer cell cytostasis induced by
bacterial enterotoxins . -
pubmed
Guanylyl cyclase C and accumulation of
cGMP induced by bacterial heat - stable enterotoxins (
STs ) promote
colon cancer cell cytostasis , serving as a
tumor suppressor in intestine . -
pubmed
Conversely , capacitative
calcium entry through
store - operated calcium channels ( SOCs ) is a key signaling mechanism that promotes
colon cancer cell proliferation . -
pubmed
These observations demonstrate that reciprocal regulation of
guanylyl cyclase C signaling by capacitative
calcium entry through SOCs represents one limb of a coordinated mechanism balancing
colon cancer cell proliferation and cytostasis . -
pubmed
They suggest that combining
guanylyl cyclase C agonists and
SOC inhibitors offers a novel paradigm for
cGMP - directed therapy and prevention for colorectal
tumors . -
pubmed
It has also been proposed that potentiation of the
AMPA receptor (
AMPAR ) function may be useful in the treatment of
depression . -
pubmed
Immunoreactivities of
p62 , an ubiqutin - binding protein , in the spinal anterior horn cells of
patients with
amyotrophic lateral sclerosis . -
pubmed
An ubiquitin - binding protein ,
p62 , is one of the components of the ubiquitin - containing inclusions in several
human neurodegenerative diseases . -
pubmed
We examined the spinal cord from 28
ALS cases including two
ALS with
dementia and two
ALS with basophilic inclusions , using antibody to
p62 . -
pubmed
The number of
p62 - positive inclusions observed in the remaining anterior horn cells of each section was variable among the
ALS cases . -
pubmed
As far as we examined , the 11
non - ALS cases did not show any
p62 immunoreactivities in the anterior horn cells . -
pubmed
DESIGN : The authors performed a multicenter randomized controlled study to compare cardiac
troponin release in
patients receiving either volatile anesthetics or total intravenous anesthesia for cardiac surgery on the beating heart , which is an excellent model of
human myocardial ischemia . -
pubmed
Peak postoperative
troponin I release was measured as a marker of
myocardial necrosis . -
pubmed
CONCLUSIONS :
Myocardial damage measured by cardiac
troponin release could be reduced by volatile anesthetics during OPCAB . -
pubmed
In this scenario ,
rimonabant 's anti - obesity action is accompanied by favorable changes in markers for
insulin resistance ,
C - reactive protein ,
adiponectin ,
tumor necrosis factor alpha (
TNFalpha ) . -
pubmed
Adjuvant treatment of
breast cancer : impact of monoclonal antibody therapy directed against the
HER2 receptor . -
pubmed
A humanised monoclonal antibody to the
HER2 receptor , trastuzumab , has demonstrable single - agent activity in metastatic
breast cancer and enhances the antitumour effects of chemotherapy . -
pubmed
Comparative analysis of peripheral and localised
cytokine secretion in
glioblastoma patients . -
pubmed
METHODS : To further understand the immunobiology of
glioblastomas in clinical settings , we examined the secretion of four main
cytokines in the peripheral blood and in
primary cell cultures of 33
human glioblastoma patients . -
pubmed
An ELISPOT methodology was used for the first time to examine Th1 , and Th2
cytokine secretion from both peripheral lymphocytes and
glioma tumour cells . -
pubmed
RESULTS : Th1
cytokines (
tumour necrosis factor (
TNF - alpha ) ,
interferon (
IFN - gamma ) were markedly reduced compared to control levels ( P=0.01 and P<0.001 , respectively ) , whereas in contrast , Th2 (
interleukin ( IL )- 4 and
IL-10 ) were strongly expressed in both peripheral lymphocytes and
glioma cell cultures ( P=0.05 and P<0.001 , respectively ) . -
pubmed
Furthermore , ELISPOT methodology can be used for monitoring of
cytokine secretion from
tumour cells , in addition to the well - established peripheral
cytokine secretion . -
pubmed
Multiple myeloma in a 50 - year - old with an
HLA - identical sibling . -
pubmed
All - trans - retinoic acid induces
manganese superoxide dismutase in
human neuroblastoma through
NF - kappaB. -
pubmed
These results suggest that signaling events involving
NF - kappaB and
SOD2 may contribute to the effects of
retinoids used in
cancer therapy . -
pubmed
Hypoxia abrogates the degradation of
hypoxia - inducible factors ( HIF )- 1 and - 2 , that can then bind to the
hypoxia response element within the
Epo gene , activating its transcription . -
pubmed
NO is a powerful vasodilator ,
insulin - sensitizer , inhibitor of
atherothrombosis and apoptosis , and essential for progenitor mobilization . -
pubmed
Men who have rising
PSA values following treatment with either surgery or radiation have residual
prostate cancer and are at very high risk of dying from
prostate cancer within 10 years . -
pubmed
Xenografts of MM
tumors treated with this combination had marked increases in phospho -
c - Jun - NH ( 2 )- kinase (
JNK)-positive cells and apoptosis , and corresponding reductions in
tumor burden ,
tumor vasculature , and the expression of
proliferating cell nuclear antigen and the proangiogenic
cytokine vascular endothelial growth factor . -
pubmed
These findings may have implications for therapeutic efforts using OXM as a long - acting
GLP-1R agonist for the treatment of
metabolic disorders . -
pubmed
We tested the hypothesis that the
C5b-9 membrane attack complex ( MAC ) localizes to sites of
villous injury and modulates trophoblast function . -
pubmed
Placental sections from pregnancies with no complications , intrauterine growth restriction , or
preeclampsia were immunostained and the surface density for MAC and
fibrin was determined by morphometric analysis . -
pubmed
MAC localized to
fibrin deposits in normal placentas , and especially in placentas from
IUGR and
preeclampsia . -
pubmed
Our findings demonstrate that MAC associates with
fibrin deposits at sites of
villous injury in vivo . -
pubmed
Tumor suppressor effect of
follistatin - like 1 in
ovarian and endometrial carcinogenesis : a differential expression and functional analysis . -
pubmed
By performing differential expression analysis using annealing control primer - based reverse transcription ( RT)-polymerase chain reaction ( PCR ) on pooled complementary DNA ( cDNA ) from 45
endometrial and 36 ovarian cancers and their
non - tumor samples , reduced expression of the
follistatin - like 1 (
FSTL1 ) was identified . -
pubmed
For in vitro functional study , full - length cDNA of
FSTL1 was cloned and transiently transfected into the
ovarian cancer cell line
Ovca420 and
endometrial cancer cell line
AN3CA . -
pubmed
By terminal uridine deoxynucleotidyl transferase
dUTP nick end labeling and flow cytometric analysis , higher apoptotic activity and a remarkable increase in sub - G(1 ) cell population were observed in transfected cells , suggesting that
FSTL1 induced apoptosis in
cancer cells . -
pubmed
Our findings suggested that a
tumor suppressor role of
FSTL1 may be important in ovarian and endometrial carcinogenesis . -
pubmed
This study highlights that the
SGT1 - mediated signalling cascade(s ) , which had previously only been demonstrated to be required for
Arabidopsis resistance against biotrophic pathogens , is causally involved in
F. - pubmed
The
p21 codon 31*C- and
DRD2 codon 313*T - related genotypes / alleles , but not
XRCC1 codon 399 ,
hOGG1 codon 326 , and
DRD1 - 48 polymorphisms , are correlated with the presence of
leiomyoma . -
pubmed
OBJECTIVE : To investigate whether the gene polymorphisms for
p21 ,
X - ray repair cross - complementing group 1 (
XRCC1 ) ,
human 8 - oxoguanine glycosylase 1 (
hOGG1 ) , and
dopamine D1 and D2 receptors (
DRD1 , - 2 ) are associated with
leiomyoma susceptibility . -
pubmed
RESULT(S ): The
p21 codon 31(*)C- and
DRD2 codon 313(*)T - related genotypes / alleles were associated with the presence of
leiomyomas . -
pubmed
The proportions of
p21(*)CC / CA / AA and
DRD2(*)CC / CT / TT in both groups were 27.5/68.3/4.2 % and 12.5/51.7/35.8 % (
leiomyoma ) ; and 14.3/51.8/33.9 % and 33.9/40.2/25.9 % (
nonleiomyoma ) . -
pubmed
XRCC1 ,
hOGG1 , and
DRD1 were not correlated with the presence of
leiomyomas . -
pubmed
XRCC1(*)GG / GA / AA ,
hOGG1(*)TT / TA / AA , and
DRD1(*)GG / GA / AA were 54.2/37.5/8.3 % , 36.7/44.2/19.1 % , and 3.3/25.8/70.8 % (
leiomyoma ) ; and 48.2/47.3/4.5 % , 43.6/41/15.4 % , and 3.6/25/71.4 % (
nonleiomyoma ) . -
pubmed
CONCLUSION(S ): The
p21 codon 31(*)C- and
DRD2 codon 313(*)T - related genotypes / alleles were associated with the presence of
leiomyoma . -
pubmed
XRCC1 ,
hOGG1 , and
DRD1 were not correlated with
leiomyoma development . -
pubmed
Cancer cachexia is associated with the
IL10 -1082 gene promoter polymorphism in patients with
gastroesophageal malignancy . -
pubmed
OBJECTIVE : We investigated the relation between
cytokine polymorphisms (
IL1B -511 ,
IL6 -174 ,
IL10 -1082 ,
TNFA -308 , and
LTA +252 ) and markers of nutritional status among patients with
gastroesophageal cancer to determine whether any such association was reflected by
cytokine concentrations in the
tumor or plasma compartments . -
pubmed
Tumor tissue
cytokine protein concentrations ( n = 56 ) were determined by using the Cytometric Bead Array System . -
pubmed
RESULTS :
IL10 GG and
IL6 CC polymorphisms were associated with elevated serum
C - reactive protein concentrations , and the
IL6 CC genotype was also associated with elevated
tumor tissue
cytokine concentrations . -
pubmed
At diagnosis , the
IL10 GG , but not the
IL6 , genotype was linked with increased total weight loss : 4.9 % for
AA , 7.1 % for AG , and 12.0 % for GG ( P = 0.007 ) . -
pubmed
Serum
C - reactive protein concentrations correlated with increased
weight loss ( r = 0.24 , P & lt ; 0.001 ) . -
pubmed
Compared with other genotypes , the
IL10 GG genotype retained an independent association in determining the extent of
weight loss on multivariate analysis ( 95 % CI : 0.52 , 3.43 ; P = 0.008 ) . -
pubmed
CONCLUSION : These data suggest that the
IL10 genotype of the host can influence the development of
cachexia among
patients with
gastroesophageal malignancy . -
pubmed
Consistent with the results in
mice , increased
MBL expression is linked with
pregnancy failure . -
pubmed
Univariate analysis showed that
SOD activity was significantly decreased in
ALS and
GSH - Px activity was decreased in
PD . -
pubmed
After adjusting for demographic parameters and enzyme cofactors , we could emphasize a compensatory increase of
SOD activity in
PD . -
pubmed
C2 - O - sLeX glycoproteins are
E - selectin ligands that regulate invasion of
human colon and
hepatic carcinoma cells . -
pubmed
We examined membrane expression of
C2 - O - sLe ( X ) ,
selectin binding , invasion of
human colon and
hepatic carcinoma cell lines , and mRNA levels of
alpha-2,3 fucosyltransferase (
FucT - III ) and
core 2 beta-1,6 N - acetylglucosaminyltransferase (
C2GnT1 ) genes , necessary for
C2 - O - sLe ( X ) synthesis , by quantitative reverse - transcriptase ( RT ) PCR . -
pubmed
The cell lines that expressed
C2GnT1 and
FucT - III mRNA by quantitative RT - PCR were highly positive for C2 - O - sLe(X ) by flow cytometry , and
colon carcinoma cells possessed highly active
C2GnT1 enzyme . -
pubmed
Gene knock - down of
C2GnT1 in colon and
hepatic carcinoma cells using short hairpin RNAs ( shRNA ) resulted in a 40 - 90 % decrease in
C2 - O - sLe ( X ) and a 30 - 50 % decrease in
E - selectin binding compared to control cells . -
pubmed
Invasion of hepatic and
colon carcinoma cells containing
C2GnT1 shRNA was significantly reduced compared to control cells in Matrigel assays and
C2GnT1 activity was down - regulated in the latter cells . -
pubmed
Our findings indicate that
C2GnT1 gene expression and the resulting
C2 - O - sLe ( X ) carbohydrates produced mediate the adhesive and invasive behaviors of
human carcinomas which may influence their metastatic potential . -
pubmed
Akt ,
14 - 3 - 3zeta , and
vimentin mediate a drug - resistant invasive phenotype in
diffuse large B - cell lymphoma . -
pubmed
Development of resistance to the
CHOP chemotherapeutic regimen (
cyclophosphamide ,
doxorubicin ,
vincristine ,
prednisone ) remains a major cause of treatment failure and mortality in approximately 40 % of
patients with
diffuse large B - cell lymphoma (
DLBCL ) . -
pubmed
We established
CHOP - resistant
DLBCL cells as a model system to investigate molecular mechanisms involved in multidrug resistance . -
pubmed
Two - dimensional differential in - gel ( DIGE ) analysis identified 10 differentially expressed proteins between
CHOP - sensitive and -resistant
DLBCL cells that play roles in glycolysis (
triosephosphate isomerase-1 ,
enolase-1 ) , cytoskeletal structure (
ezrin ,
vimentin ,
tubulin - specific chaperone B ) ,
purine biosynthesis (
serine hydroxymethyltransferase ) ,
calcium binding (
sorcin ) , and apoptosis (
p53 ,
14 - 3 - 3zeta ,
Akt ) . -
pubmed
Akt ,
14 - 3 - 3zeta , and
vimentin were up - regulated in
CHOP - resistant
DLBCL cells . -
pubmed
We showed previously that siRNA - mediated knockdown of
14 - 3 - 3zeta reversed
CHOP resistance in
DLBCL cells ( Maxwell et al . -
pubmed
Here we show that chemical inhibition of
Akt overcomes
CHOP resistance in
DLBCL cells . -
pubmed
Increased expressions of
Akt ,
14 - 3 - 3zeta , and
vimentin were observed by Western blotting in primary
DLBCL tissues relative to
normal lymphatic tissue . -
pubmed
The data implicate activation of an
Akt-14 - 3 - 3zeta signaling pathway in promoting a multidrug - resistant phenotype associated with a
vimentin - dependent invasive behavior in
DLBCL cells . -
pubmed
NGAL as an early biomarker of
kidney disease in
Joubert syndrome : three brothers compared . -
pubmed
We measured
neutrophil gelatinase - associated lipocalin (
NGAL ) , considered as an excellent predictor of
kidney injury , to evaluate whether this biomarker might be an early biomarker for
JBTS - related kidney disease . -
pubmed
NGAL could represent an early indicator of
renal damage useful to start an intensive nephrologic follow - up . -
pubmed
Fatal delayed
hemolytic transfusion reaction associated with
anti - Di ( b ) and anti - E. We report the death of a 61 - year - old Japanese
man massively transfused during and after emergency aortic surgery . -
pubmed
The characteristic histopathological features and the presence of spindle cells expressing
smooth muscle actin ,
collagen fibers and lymphocytes allowed for the diagnosis of
liver IMT . -
pubmed
gamma - Hydroxybutyric acid induces actions via the
GABAB receptor in arousal and motor control - related nuclei : implications for therapeutic actions in
behavioral state disorders . -
pubmed
Aortic valve stenosis and
atrial fibrillation influence plasma
fibulin-1 levels in
patients treated with coronary bypass surgery . -
pubmed
In this study , we addressed the hypothesis that
fibulin-1 levels reflect
myocardial fibrosis . -
pubmed
Patients with
AS or
atrial fibrillation (
AF ) had significantly higher
fibulin-1 levels compared to those with
coronary artery disease only ( p = 0.005 ) . -
pubmed
Patients with preoperatively diagnosed chronic
AF had significantly higher levels of
fibulin-1 compared to those without ( p = 0.004 ) . -
pubmed
CONCLUSION : This study shows that plasma
fibulin-1 levels are increased in
patients with
AS and
AF compared to
patients with
coronary disease only . -
pubmed
Our study results suggest
fibulin-1 , a vascular extracellular matrix ( ECM ) protein , as a marker of ECM turnover perhaps due to the increased myocardial stretch that is related to
pressure overload . -
pubmed
The discovery that
Rett syndrome (
RTT ) is caused by mutation of the
methyl -
CpG - binding - protein
MeCP2 provided a major breakthrough in understanding the
neurodevelopmental disorder and accelerated
MeCP2 research . -
pubmed
Association study of
cathepsin D gene polymorphism in Iranian patients with sporadic late - onset
Alzheimer ' s disease . -
pubmed
A key event in the pathogenesis of
AD is the deposition of beta - amyloid peptide , which is derived from the
amyloid precursor protein by
beta - and gamma - secretases . -
pubmed
An exonic C T polymorphism at position 224 of the
CTSD gene ( rs : 17571 ) has been shown to be associated with the enzyme function of
CTSD and with
AD . -
pubmed
Our results indicate that
CTSD genotype is associated with the disease and a combination of the above risk factors significantly alters the risk for developing
AD . -
pubmed
The Biological Role of
PI3 K Pathway in
Lung Cancer . -
pubmed
Numerous downstream molecular pathways , such as
EGF /
RAS /
RAF /
MEK /
ERK and
PI3K /
AKT /
mTOR are identified as having a key role in the pathogenesis of various forms of
human cancer , including
lung cancer . -
pubmed
In this review article , we investigate thoroughly the biological role of
PI3 K pathway in
lung cancer and its contribution in the development of future therapeutic strategies . -
pubmed
BTG2 overexpression increases the radiosensitivity of
breast cancer cells in vitro and in vivo . -
pubmed
In this study , we investigated the effect of
BTG2 gene overexpression on the radiosensitivity of
breast cancer cells in vitro and in vivo . -
pubmed
Results show that in
human breast cancer cell line
MCF-7 stably overexpressing
BTG2 gene , cell sensitivity to ionizing radiation increased . -
pubmed
The findings indicate for the first time that
BTG2 can improve the radiosensitivity of
breast cancer cells by affecting cell cycle distribution , enhancing radiation - induced apoptosis , and inhibiting DNA repair - related protein expression . -
pubmed
We found that
RSV infection induces a non - canonical ER stress response with preferential activation of the
inositol - requiring enzyme 1 (
IRE1 ) and
activated transcription factor 6 (
ATF6 ) pathways with no concomitant significant activation of the
protein kinase R - like ER kinase (
PERK ) pathway . -
pubmed
Our data characterize , for the first time , the nature of the ER stress response in the setting of
RSV infection and identify the
IRE1 stress pathway as a novel cellular anti -
RSV defense mechanism . -
pubmed
RESULTS :
Manumycin treatment resulted in significant decreases in the viabilities of the two
prostate cancer cell lines in a dose - dependent manner through apoptosis , and this apoptosis involved
caspase-9 activation . -
pubmed
A specific inhibitor of
caspase-9 protected cells from
caspase-3 activation , apoptosis , and
cytotoxicity induced by
manumycin . -
pubmed
CONCLUSION : Our data suggest that
manumycin induces apoptosis in
prostate cancer cells through regulation of the
Bcl-2 family involving
caspase-9 activation . -
pubmed
METHODS : Data are from individuals in the Detroit Neighborhood Health Study tested for herpes simplex virus-1 (
HSV-1 ) and
cytomegalovirus (
CMV ) seropositivity /
immunoglobulin G (
IgG ) antibody levels ( N=263 ) as well as
interleukin-6 (
IL-6 ) ( N=245 ) and
C - reactive protein (
CRP ) ( N=236 ) levels and assessed for incident
depression via the Patient Health Questionnaire-9 . -
pubmed
Linear and logistic regression models were used to examine associations between pathogen seropositivity /
IgG antibody levels , pro - inflammatory markers and incident
depression over approximately one - year of follow - up . -
pubmed
RESULTS : For every one unit increase in
CMV IgG antibody level , the odds of incident
depression increased by 26 % and individuals with
IgG antibody levels in the highest quartile had over three times greater odds of incident
depression ( odds ratio 3.87 , 95 % confidence interval 1.47 , 10.19 ) , compared to those in the lower three quartiles . -
pubmed
Neither
CMV or
HSV-1 seropositivity nor
HSV-1 IgG antibody level were associated with
IL-6 or
CRP levels at Wave 1 , nor were
IL-6 or
CRP levels associated with incident
depression at Wave 2 . -
pubmed
Synchronous
GH- and
prolactin - secreting
pituitary adenomas . -
pubmed
We report a case of synchronous secretory
pituitary adenomas in a
woman who initially presented with elevated
prolactin levels . -
pubmed
Pathological analysis demonstrated one
tumor as a
prolactinoma , and the other
tumor as a
GH - secreting
adenoma . -
pubmed
This case highlights that
GH and
prolactin level elevation is not always from co - secretion by the same
adenoma . -
pubmed
In the setting of elevated
GH and
prolactin levels , one can not assume that they are co - secreted by the same
adenoma . -
pubmed
A core needle biopsy from the renal mass demonstrated numerous
histiocytoid that were positive for
CD163 and
S100 protein . -
pubmed
Moreover , scintigraphic images from cell plates and
mouse xenografts showed stronger signals from opt -
hNIS - expressing cells than
hNIS - expressing cells , and radioactivity uptake by opt -
hNIS - expressing
tumors was 2.3 - fold greater than that by
hNIS - expressing
tumors . -
pubmed
To test the efficacy of
radioiodine therapy ,
mouse xenograft models were established with
cancer cells expressing
hNIS or opt -
hNIS . -
pubmed
131I treatment reduced
tumor sizes of
hNIS- and opt -
hNIS - expressing
tumors to 0.57- and 0.27- fold , respectively , compared to their sizes before therapy , suggesting an improved therapeutic effect of opt -
hNIS . -
pubmed
46,XY
Gonadal Dysgenesis due to a Homozygous Mutation in
Desert Hedgehog (
DHH ) Identified by Exome Sequencing . -
pubmed
The gonads of one patient showed partial
gonadal dysgenesis with loss of Leydig cells in tubular areas with
seminoma in situ and a
hyperplasia of Leydig cell - like cells expressing
CYP17A1 in more dysgenetic parts of the gonad . -
pubmed
CONCLUSION : Mutations in
DHH play a role in
46,XY gonadal dysgenesis and are associated with
seminoma formation and a
neuropathy with minifascicle formation . -
pubmed
The
lysyl oxidase inhibitor
beta - aminopropionitrile reduces body weight gain and improves the metabolic profile in diet - induced
obesity in
rats . -
pubmed
The
lysyl oxidase ( LOX ) family of amine oxidases , including
LOX and
LOX - like (
LOXL ) isoenzymes , controls ECM maturation , and upregulation of
LOX activity is essential in
fibrosis ; however , its involvement in
adipose tissue dysfunction in
obesity is unclear . -
pubmed
In this study , we observed that
LOX is the main isoenzyme expressed in
human adipose tissue and that its expression is strongly upregulated in samples from
obese individuals that had been referred to bariatric surgery . -
pubmed
Interestingly , treatment with
beta - aminopropionitrile (
BAPN ) , a specific and irreversible inhibitor of
LOX activity , attenuated the increase in body weight and fat mass that was observed in
obese animals and shifted adipocyte size toward smaller adipocytes . -
pubmed
BAPN also ameliorated the increase in
collagen content that was observed in adipose tissue from
obese animals and improved several metabolic parameters - it ameliorated
glucose and
insulin levels , decreased homeostasis model assessment ( HOMA ) index and reduced plasma
triglyceride levels . -
pubmed
Furthermore , in white adipose tissue from
obese animals ,
BAPN prevented the downregulation of
adiponectin and
glucose transporter 4 (
GLUT4 ) , as well as the increase in
suppressor of cytokine signaling 3 (
SOCS3 ) and
dipeptidyl peptidase 4 (
DPP4 ) levels , triggered by the HFD . -
pubmed
Therefore , our data provide evidence that
LOX plays a pathologically relevant role in the
metabolic dysfunction induced by
obesity and emphasise the interest of novel pharmacological interventions that target adipose tissue
fibrosis and
LOX activity for the clinical management of this disease . -
pubmed
Effectiveness of
Botulinum Toxin for
Shoulder Pain Treatment : A Systematic Review and Meta - Analysis . -
pubmed
OBJECTIVE : To evaluate the current evidence of the effectiveness of
botulinum toxin ( BTX ) treatment for
shoulder pain . -
pubmed
miR-155 Drives Metabolic Reprogramming of ER+
Breast Cancer Cells Following Long - Term
Estrogen Deprivation and Predicts Clinical Response to
Aromatase Inhibitors . -
pubmed
Aromatase inhibitors ( AI ) have become the first - line endocrine treatment of choice for postmenopausal
estrogen receptor - positive (
ER (+ ) ) breast cancer patients , but resistance remains a major challenge . -
pubmed
This effect was
ER dependent as
breast cancer cells with undetectable levels of
ER failed to exhibit metabolic plasticity . -
pubmed
MDW was positively correlated with
PC ( r=0.156 , P=0.047 ) and
CRP ( r=0.591 , P<0.001 ) . -
pubmed
INTRODUCTION :
Adiponectin (
APN ) , an adipocytokine , exerts protective effects on cardiac remodeling , while
angiotensin II (
Ang II ) induces
hypertension and vascular remodeling . -
pubmed
The potential protective role of
APN on the vasculature during
hypertension has not been fully elucidated yet . -
pubmed
METHODS AND RESULTS :
Rat aortic tissues were used to investigate the effect of
APN on
Ang II - induced vascular remodeling and
hypertrophy . -
pubmed
We investigated whether
nitric oxide (
NO ) , the
RhoA /
ROCK pathway ,
actin cytoskeleton remodeling , and reactive
oxygen species ( ROS ) mediate the anti -
hypertrophic effect of
APN . -
pubmed
The
hypertrophic response to
Ang II was associated with a significant increase in
RhoA activation and vascular force production , which were prevented by
APN and
SNAP . -
pubmed
RESULTS : Regulatory T ( Treg ) cells and their
cytokines , primarily
interleukin ( IL ) 10 and
transforming growth factor beta , suppress T - helper type 2 immune responses and control
allergic diseases in many ways . -
pubmed
DISCUSSION : Recurrent elevations in
cortisol in response to
hypoglycemia may be the underlying pathology leading to suppression of
gonadotropin - releasing hormone (
GnRH ) release . -
pubmed
RESULTS : The anti - HSV -
UL29 siRNA swarm alleviated
HSV infection symptoms , inhibited viral shedding and replication and had a favourable effect on
mouse survival . -
pubmed
CONCLUSIONS : Treatment with anti - HSV -
UL29 siRNA swarm reduced symptoms and viral spread in
HSV infection of
mice and also inhibited local viral replication in
mouse corneas . -
pubmed
Oleanolic acid ( OA ) regulates
inflammation and cellular dedifferentiation of chondrocytes via
MAPK signaling pathways . -
pubmed
These results suggest that OA induces loss of
type II collagen expression via the
p38 pathway and induces
inflammation through the
p38 and
ERK pathways in
rabbit articular chondrocytes . -
pubmed
Cerebrospinal fluid /
serum albumin ratio is one of the most informative parameters for blood - brain barrier ( BBB ) integrity in cases of
central nervous system ( CNS ) infectious diseases . -
pubmed
The results demonstrated typical patterns which prove
albumin to be the main modulator of protein dynamics and at the same time explicates the complex pathophysiological mechanisms involved in BBB disruption and intrathecal immune response in
CNS infections . -
pubmed
t(11;14)-positive
mantle cell lymphomas lacking
cyclin D1 (
CCND1 ) immunostaining because of a
CCND1 mutation or exclusive expression of the
CCND1b isoform . -
pubmed
Lymphomas with pseudo - double - hit
BCL6 -
MYC translocations due to t(3;8)(q27;q24 ) are associated with a germinal center immunophenotype , extranodal involvement , and frequent
BCL2 translocations . -
pubmed
High - grade B - cell
lymphomas with
MYC ,
BCL2 , and/or
BCL6 rearrangements , " double - hit " or " triple - hit "
lymphomas (
DTHL ) , are aggressive
neoplasms associated with a poor prognosis . -
pubmed
A t(3;8)(q27;q24 ) rarely occurs in
B - cell lymphomas that results in a unique " pseudo - double - hit "
BCL6 -
MYC fusion , indistinguishable by interphase fluorescence in situ hybridization ( FISH ) from more conventional
DTHL with independent
MYC and
BCL6 translocations . -
pubmed
When compared to two large published
DTHL cohorts , t(3;8)(q27;q24 )
lymphomas less often expressed
BCL2 ( P & lt ; .01 ) , had a greater likelihood of extranodal involvement ( P & lt ; .01 ) , and more frequently appeared triple - hit by FISH analysis ( P & lt ; .01 ) . -
pubmed
TAA and
AAD share common etiology as
monogenic diseases linked to
transforming growth factor beta signaling pathway , extracellular matrix defect , or smooth muscle cell protein mutations . -
pubmed
The study elucidates the effect of
alpha - linolenic acid (
ALA ) on mitochondrial stress ,
hypoxic cancer microenvironment , and intervention of cholinergic anti - inflammatory pathway using
N - methyl - N - nitrosourea (
MNU ) induced
estrogen receptor (
ER+ )
mammary gland carcinoma and
Caenorhabditis elegans model , respectively . -
pubmed
It was concluded that
ALA persuaded the mitochondrial stress , activation of downstream cholinergic anti - inflammatory markers , and favorable regulation of
hypoxia microenvironment through inhibition of
fatty acid synthase and
sterol regulatory element - binding protein . -
pubmed
We have previously shown that agricultural organic dust extract ( ODE ) , with abundant microbial component diversity , activates
TLR - induced
airway inflammation . -
pubmed
Increased
Muc5ac levels in
MyD88 - deficient
mice were also not explained by augmented
inflammation ,
IL-17A , or
neutrophil elastase levels . -
pubmed
By exploiting the paramagnetic properties of deoxygenated
hemoglobin in venous blood using magnetic resonance imaging ( MRI ) quantitative susceptibility mapping ( QSM ) , we aimed to explore venous density and
oxygen saturation ( SvO2 ) in
patients with a
brain AVM . -
pubmed
These results suggest that
PTN may be a novel candidate to improve
sensorineural hearing loss treatment in the future . -
pubmed
Regulation of the
SIRT1 signaling pathway in
NMDA - induced
Excitotoxicity . -
pubmed
The present study is to investigate the potential pathway of
SIRT1 in the
SH - SY5Y cell line as an in vitro model of
NMDA - induced
neurotoxicity . -
pubmed
Therefore , the study suggests that inhibition of
Ca2 + -PKC -
HuR -
SIRT1 pathway could be an effective strategy for preventing certain
neurological diseases related to
NMDA excitotoxicity . -
pubmed
PI3K /
AKT signaling is known to regulate
cancer metabolism , but whether metabolic feedback regulates the
PI3K /
AKT pathway is unclear . -
pubmed
PPP metabolites , in turn , reinforce
AKT activation and further promote
cancer metabolic reprogramming by blocking the expression of the
AKT inhibitor
PHLDA3 . -
pubmed
Importantly ,
PTEN null
human cancer cells and in vivo
murine models are sensitive to anti - PPP treatments , suggesting the importance of the
PPP in maintaining
AKT activation even in the presence of a constitutively activated
PI3 K pathway . -
pubmed
Our study suggests that blockade of this reciprocal crosstalk mechanism may have a therapeutic benefit for
cancers with
PTEN loss or
PI3K /
AKT activation . -
pubmed
Identification of
METTL3 as an Adverse Prognostic Biomarker in
Hepatocellular Carcinoma . -
pubmed
Joint effects analysis showed the predictive capacity of combining
METTL3 ,
YTHDF2 , and
ZC3H13 for
HCC OS . -
pubmed
CNV and DNA methylation , but not somatic mutations , might contribute to the abnormal upregulation of
METTL3 in
HCC . -
pubmed
Significantly altered genes , microRNAs , and lncRNAs were identified , and a ceRNA regulatory network was constructed to explain the upregulation of
METTL3 in
HCC . -
pubmed
CONCLUSIONS : Our study identified several m6A - related genes , especially
METTL3 , that could be potential prognostic biomarkers in
HCC . -
pubmed
Erratum : Long Noncoding RNA
H19 Facilitates Small Cell
Lung Cancer Tumorigenesis Through miR-140 - 5p /
FGF9 Axis [ Corrigendum ] . -
pubmed
PRAME expression in
melanocytic proliferations with intermediate histopathologic or spitzoid features . -
pubmed
BACKGROUND :
PRAME ( PReferentially expressed
Antigen in
MElanoma ) has shown utility in distinguishing
melanoma from benign
melanocytic lesions , but knowledge of its expression pattern in intermediate melanocytic and spitzoid proliferations is limited . -
pubmed
METHODS : Immunohistochemical expression of
PRAME was examined in 112
melanocytic proliferations with intermediate histopathologic or spitzoid features . -
pubmed
Nearly all
non - spitzoid melanomas ( 23/24 ; 95.8 % ) demonstrated diffuse
PRAME expression . -
pubmed
PRAME was completely negative in 95.6 % ( 43/45 ) of mitotically - active
nevi ,
traumatized nevi ,
nevi with persistent / recurrent features , and
dysplastic nevi . -
pubmed
Most
Spitz nevi ( 15/20 ) and
atypical Spitz tumors ( 10/13 ) entirely lacked
PRAME expression . -
pubmed
One
Spitz nevus , one atypical
Spitz tumor , and one case of
spitzoid melanoma ( 1/2 ) demonstrated diffuse
PRAME expression . -
pubmed
CONCLUSIONS : Although diffuse
PRAME expression is generally limited to
malignant melanoma , benign
Spitz nevi and
atypical Spitz tumors can infrequently express diffuse
PRAME . -
pubmed
PRAME immunohistochemistry can be useful in the evaluation of atypical
melanocytic proliferations with intermediate histopathologic features but should be interpreted with caution in the setting of
spitzoid neoplasms . -
pubmed
The purpose of the present study was to investigate the endocrine disrupting
toxicity of
CYP ,
MAT , and
CYP +
MAT to 5 - month - old male
zebrafish (
Danio rerio ) . -
pubmed
The
human forearm technique was employed to determine changes in plasma levels and peripheral fluxes of TG ,
FFA and
glycerol in a group of
insulin independent
diabetics before and after administration of
sodium pentosan polysulphate . -
pubmed
Use of recombinant
erythropoietin in
thalassemic patients on dialysis . -
pubmed
We studied the therapeutic benefit of
recombinant human erythropoietin (
rHuEPO ) in dialysis
patients with
thalassemia minor . -
pubmed
Four of the 40 randomly selected
patients ( 22 on hemodialysis [ HD ] , 18 on continuous ambulatory peritoneal dialysis [ CAPD ] ) were identified to be
thalassemic prior to a trial of
rHuEPO ( alpha - thalassemia trait in three and
beta - thalassemia minor in one ) . -
pubmed
All nonthalassemic
patients reached a target
hemoglobin of 10 g / dL at week 16 , with an average maintenance dose of 120 + /- 7.8 U / kg / wk , but the
hemoglobin was increased by only 1 g / dL in the
thalassemic patients receiving 175 U / kg / wk . -
pubmed
Following cessation of
rHuEPO therapy for 6 weeks , all four
thalassemic patients and 18 randomly selected nonthalassemic
patients received a fixed dose of
rHuEPO 4,000 U / wk ( equivalent to 80 U / kg / wk ) for 16 weeks . -
pubmed
The
hemoglobin remained unchanged in the
thalassemic patients , but a progressive and significant increase of
hemoglobin was observed in the nonthalassemic
patients . -
pubmed
At the last phase of the study , the
thalassemic patients received
rHuEPO at a dose of 100 or 125 U / kg / wk with 4 - weekly increments of 25 U / kg / wk until their
hemoglobin reached 10 g / dL. -
pubmed
One
patient developed uncontrolled
hypertension with a dose of 150 U / kg / wk , and one reached the target
hemoglobin at a dose of 200 U / kg / wk. -
pubmed
Although the
PHA - induced mitogen response of lymphocytes from the other three lymphoid compartments remained suppressed throughout the study period , the response to the
mitogens Con - A and PWM generally returned to normal or supranormal levels by the seventh postburn day , Therefore it appears that the effect of a
thermal injury on lymphocyte function varies according to the lymphocyte compartment examined and the
mitogen tested . -
pubmed
Due to critical
amino acid changes in the 72 - 89 sequence , the determinant of
human ( Hu ) basic protein (
BP ) that induces experimental
autoimmune encephalomyelitis (
EAE ) in Lewis
rats most likely differs from
rat and
guinea pig BP . -
pubmed
T cells specific for the 87 - 99 determinant recognized both Hu- and
Rt - BP , were highly encephalitogenic , and accounted for the experimental
autoimmune encephalomyelitis - inducing activity of the
Hu - BP line . -
pubmed
Seasonal and mood independence of low basal
prolactin secretion in premenopausal
women with
seasonal affective disorder . -
pubmed
To test hypotheses of opposing roles of
dopamine and
serotonin in
prolactin secretion in
seasonal affective disorder , the authors determined basal
serum prolactin concentrations for premenopausal
women , eight with and 14 without
seasonal affective disorder , in late afternoon during the follicular phase of the menstrual cycle ( and a subgroup during the luteal phase ) in winter and summer . -
pubmed
Despite their significantly higher Hamilton
depression scale scores in winter than in summer , the
patients had significantly lower
prolactin concentrations than the control subjects in both seasons . -
pubmed
These results suggest that low
prolactin secretion may be a trait characteristic in
seasonal affective disorder . -
pubmed
We have previously reported that
5 '- aminothymidine (
5 '- AdThd ) , an antagonist of the feedback inhibition exerted by
dTTP that regulates
thymidine kinase , enhances the uptake and
cytotoxicity of
5 - iododeoxyuridine in various
human bladder cancer cell lines but not in normal
human urothelial cells (
HU ) propagated in vitro . -
pubmed
The
patient with deposition of
immunoglobulin along the perineurium had severe
demyelination and severe
peripheral sensory - motor neuropathy , while the
patient with
immunoglobulin deposition along the myelin sheaths had a slight
sensory neuropathy which had not progressed for 4 years . -
pubmed
Predicting bone marrow
iron stores in
anemic patients in a community hospital using
ferritin and erythrocyte sedimentation rate . -
pubmed
A two - dimensional linear graphic relationship between
ferritin and ESR correctly identified six of nine
iron - deficient patients and 32 of 34
iron - present patients . -
pubmed
Nine immunologically characterized cleaved FCC
lymphomas with
sclerosis and 14 reactive lymph nodes with
follicular hyperplasia were investigated by special staining methods , electron microscopy , and immunohistochemical studies with antibodies to
types I , III , IV , and V collagen ,
laminin , and
fibronectin . -
pubmed
Weak pericellular staining for
type V collagen was present in eight of nine
lymphomas and half of the control lymph nodes . -
pubmed
These studies suggest that the increased amounts of extracellular matrix in cleaved FCC
lymphomas are produced primarily by fibroblasts and myofibroblasts and represent predominantly
fibronectin and
types I , III , and V collagen . -
pubmed
[ Evaluation of the behavior of the
antistreptokinase titer , erythrocyte sedimentation and antistreptolysin titer in
focal diseases of tonsillar etiology ] . -
pubmed
Norepinephrine and
renin activity in
chronic renal failure . -
pubmed
To assess the interaction between adrenergic activity and blood pressure regulation in
patients with
chronic renal failure , plasma
norepinephrine ( NE ) and
plasma renin activity ( PRA ) were measured before and after vigorous ultrafiltration . -
pubmed
These results indicate that hemodialysis mobilizes the
renin -
angiotensin system to maintain
hypertension in a greater proportion of dialysis
patients than previously supposed and that impaired
renin release following
hypotension may represent
uremic autonomic dysfunction . -
pubmed
Structural and functional differences of subspecies of
apoA - I - containing lipoprotein in
patients with plasma
cholesteryl ester transfer protein deficiency . -
pubmed
We propose that the structure and function of
LpA - I and
LpA - I / A - II are severely affected in the presence of
CETP deficiency . -
pubmed
The following parameters were investigated : sex , age , serum lipid levels ( total
cholesterol ,
HDL cholesterol ,
triglycerides ) , presence of
diabetes mellitus , height , body mass index ( BMI ) , and average daily consumption of coffee ,
tobacco and
alcohol . -
pubmed
[ The antibacterial effects of homologous
interferons in an experimental
staphylococcal infection ] . -
pubmed
Homologous
interferons (
IF ) of the 1st and 2nd types are studied for their effect on the course of experimental
staphylococcal infection . -
pubmed
Vicinal dihaloalkanes are transformed by
glutathione S - transferase - catalyzed reactions to mutagenic and
nephrotoxic S -( 2 - haloethyl ) glutathione S - conjugates . -
pubmed
Beta - Lyase - dependent metabolism of
halovinyl cysteine S - conjugates yields electrophilic
thioketenes , whose covalent binding to cellular macromolecules is responsible for the observed
toxicity of the parent compounds . -
pubmed
Reports of different awareness of
hypoglycemic symptoms during
hypoglycemia induced by
human insulin ( HI ) and
porcine insulin ( PI ) suggest a modulatory influence of
insulin on sensory processing . -
pubmed
Differences between the effects of the
insulins were consistently apparent after 20 min of
hypoglycemia , which indicates a short - term action of the hormone . -
pubmed
A significant proportion of
LHON patients had circulating antibodies to
tubulin protein . -
pubmed
Mutations in the gene encoding
cystatin B in
progressive myoclonus epilepsy (
EPM1 )
Progressive myoclonus epilepsy of the
Unverricht - Lundborg type (
EPM1 ) is an
autosomal recessive inherited form of epilepsy , previously linked to
human chromosome 21q22.3 . -
pubmed
Two mutations , a 3 ' splice site mutation and a stop codon mutation , were identified in the gene encoding
cystatin B in
EPM1 patients but were not present in unaffected
individuals . -
pubmed
These results provide evidence that mutations in the gene encoding
cystatin B are responsible for the primary defect in
patients with
EPM1 . -
pubmed
OBJECTIVE : To evaluate the value of fecal leukocytes , fecal occult blood , fecal
lactoferrin and combination of fecal leukocytes with clinical data in the workup of patients with
inflammatory diarrhea . -
pubmed
Our aim was to determine the effects of
As ( III ) pretreatment on the acute
toxicity of PA and its possible relationship with the effects of
As ( III ) on
P-450 - dependent
monooxygenase activities . -
pubmed
Our results also indicated that the increase in PA
toxicity caused by
As ( III ) pretreatment , could also be related to the
CYP2B2 isoform , since decreases in
CYP2B2 - dependent
BROD activity were observed in both
As ( III ) and
As ( III ) + PA groups , but not in PA - treated
animals , suggesting that
CYP2B2 is involved in PA detoxification . -
pubmed
METHODS : We analyzed growth and
GH secretion in 60
children in complete remission after treatment by chemotherapy and surgery for
malignant solid tumors . -
pubmed
The growth rate in conjunction with the
GH response to
clonidine provides a sensitive measure of
GHD associated with chemotherapy . -
pubmed
Mice homozygous for a deletion in the gene for
CEBPalpha (
C / EBPalpha-/-
mice ) die shortly after birth of
hypoglycemia , with no detectable hepatic
PEPCK mRNA and negligible hepatic glycogen stores . -
pubmed
Half of the
mice homozygous for a deletion in the gene for
CEBPbeta (
C / EBPbeta-/-
mice ) have normal
glucose homeostasis ( phenotype A ) , and the other half die at birth of
hypoglycemia due to a failure to express the gene for
PEPCK and to mobilize hepatic glycogen ( phenotype B ) . -
pubmed
Insulin deficiency induces
C / EBPalpha and
PEPCK gene transcription in the livers of 19 - day fetal
rats , whereas
dibutyryl cyclic AMP (
Bt2cAMP ) increases the expression of the gene for
C / EBPbeta and causes a transient burst of
PEPCK mRNA . -
pubmed
Human cytomegalovirus late - phase maturation is blocked by stably expressed
UL32 antisense mRNA in
astrocytoma cells . -
pubmed
Thus ,
hypoglycaemia caused
LH inhibition after higher doses of
IGF-1 , which counteracted ( E- ) or overcame ( E+ ) the stimulatory effects on
LH seen after lower doses . -
pubmed
OBJECTIVE : We applied isolated
IgE - binding components ( major allergens ) in the technique of bronchial allergen challenge to determine the role of
patient characteristics in the early
asthmatic response ( EAR ) . -
pubmed
Moreover , no significant contribution of these indices of
IgE - mediated
hypersensitivity to the prediction of PD20allergen by multilinear regression models with
PC20histamine was found . -
pubmed
Increased serum concentrations of
secretory leukoprotease inhibitor in
patients with primary
Sjogren ' s syndrome . -
pubmed
OBJECTIVE : We sought to assess whether serum levels of
SLPI in
patients with primary
Sjogren ' s syndrome (
SS ) are elevated and correlated with conventional and laboratory indices of disease activity . -
pubmed
PATIENTS AND METHODS :
SLPI levels were determined by ELISA of serum from 21 primary
SS , and 26 age - matched normal controls . -
pubmed
RESULTS : Increased
SLPI concentrations were found in primary
SS patients ( p & lt ; 0.01 ) . -
pubmed
CONCLUSION : Determination of serum
SLPI may provide a new simple noninvasive technique for evaluation of primary
SS . -
pubmed
Roles of
histamine receptor in a
guinea pig asthma model . -
pubmed
Histamine plays an important role in bronchoconstriction mediated by
histamine receptors which provoke
bronchial asthma attack . -
pubmed
These findings suggest a close association of
Histamine receptors both
H1 and
H2 in the pathology of
asthma . -
pubmed
Budd - Chiari syndrome associated with
factor V leiden mutation : a report of 6 patients . -
pubmed
Resistance to
activated protein C caused by
factor V Leiden mutation has been recently identified as a major cause of
thrombophilia . -
pubmed
We report 6 patients with
Budd - Chiari syndrome associated with
factor V Leiden mutation combined with another acquired
thrombophilic state (
myeloproliferative disorder and
lupus anticoagulant in 3 cases ) and without another
thrombophilic disorder in the other 3 cases . -
pubmed
We conclude that
factor V Leiden mutation should be evaluated in any case of
hepatic vein occlusion because the prevalence of this mutation in the general population is high . -
pubmed
spiralis muscular larva antigens (
TsMLA ) against several sera from
patients with other
parasitic diseases by ELIB ( enzyme - linked immunoblotting technique ) were studied . -
pubmed
The cross reactions of
TsMLA against
Schistosoma japonicum may be differentiated on the positive reaction bands of 44/45 , 51/53 , 62/64 and 100 KDa proteins which was specific to the
chronic schistosomiasis using the TsMLA by means of ELIB . -
pubmed
MATERIAL AND METHODS : In a
rat model of 30 min of intestinal
ischemia and reperfusion , the number of PMNs was manipulated : group A , control ; group B ,
leukopenia induced by
cyclophosphamide ; group C ,
leukocytosis induced by
granulocyte colony - stimulating factor (
G - CSF ) . -
pubmed
In group C , tissue pH was significantly lower than in other groups during I / R. CONCLUSION :
Leukocytosis induced by
G - CSF exerts a prolonged effect on
ATP during I / R and leukocyte depletion helps protect against the I / R injury . -
pubmed
One highly conserved feature of the
Wilms ' tumour suppressor gene ,
WT1 , is the potential , following alternative pre - mRNA splicing , to insert three amino acids ( KTS ) between the third and fourth zinc fingers . -
pubmed
Pteridin - dependent hydroxylases as autoantigens in
autoimmune polyendocrine syndrome type I. -
pubmed
We have earlier reported the identification of
tryptophan hydroxylase (
TPH ) and
tyrosine hydroxylase (
TH ) as autoantigens in
APS I associated with
intestinal dysfunction and
alopecia , respectively . -
pubmed
Of the
APS I patients , 25 % had
PAH antibodies , and no reactivity was detected in the controls . -
pubmed
No association with the main clinical components of
APS I was found with
PAH antibodies . -
pubmed
Altogether , 59 sera from the 94
APS I patients reacted with at least one of
TPH ,
TH , or
PAH , whereas 35 showed no reactivity . -
pubmed
The chorioallantoic membrane ( CAM ) of the fertilized egg allows grafting of
human melanomas for short - term investigations and offers the opportunity to investigate the behavior of metastasizing cells and the release of
S100beta into peripheral blood . -
pubmed
Tissue from one primary
melanoma as well as cutaneous and subcutaneous metastases of 10
melanoma patients with elevated levels of
S100 in the peripheral blood before surgery were transplanted onto the CAM of chick embryos at day 5/6 of development . -
pubmed
Samples deriving from
melanoma xenografts contained highly elevated levels of
S100 protein in 80 % of cases . -
pubmed
The putative mutants were tested for
VirB8 function by the ability to complement a
virB8 deletion mutant in
tumor formation assays . -
pubmed
When introduced into the wild - type strain ,
virB8(S87L ) partially suppressed the
tumor forming ability of the wild - type protein . -
pubmed
Expression of
alpha - synuclein in a
human glioma cell line and its up - regulation by
interleukin-1beta . -
pubmed
Although
alpha - synuclein is expressed primarily in neurons , it is a major component of oligodendroglial and astrocytic inclusions in several
neurodegenerative diseases . -
pubmed
alpha - Synuclein mRNA and protein were detected in
U251 human astrocytic glioma cells and normal
human astrocytes , and the levels were increased in the former , but not in the latter , by stimulation with
interleukin-1beta in a time- and concentration - dependent manner . -
pubmed
To determine the reference intervals of urinary
albumin ,
immunoglobulin G ,
transferrin ,
alpha 1 microglobulin , and
N - acetyl - beta - D - glucosaminidase , we measured those components and
creatinine in urine from
men with normal blood pressure(systolic & lt ; or = 139 mmHg and diastolic & lt ; or = 89 mmHg ) , HbA1c & lt ; or = 5.8 % and negative qualitative tests of urinary protein and
hematuria . -
pubmed
The icv infusion of the selective
glucocorticoid receptor antagonist
RU38486 blocked the
hyperphagic effects of twice - daily icv injections of
DEX in both sexes . -
pubmed
Sensitive and specific detection of circulating
cancer cells in
patients with
hepatocellular carcinoma ; detection of
human telomerase reverse transcriptase messenger RNA after immunomagnetic separation . -
pubmed
CONCLUSIONS : These results strongly suggest that detection of
hTERT mRNA after immunomagnetic separation is a specific and sensitive tool to detect
CC cells and that it would provide useful source for further investigation of
cancer metastasis . -
pubmed
[ Histochemistry of nonspecific
esterase activities in
human tumors . -
pubmed
[ PATHOGENESIS AND THERAPY OF
RETINAL DETACHMENT ] . -
pubmed
In this study , we examined the potential integration and distribution of
GX-12 , a new therapeutic vaccine for
HIV infection , at various times in muscles and reproductive organs of
rats . -
pubmed
Endothelial nitric oxide synthase gene polymorphisms in
Behcet ' s disease and
rheumatic diseases with
vasculitis . -
pubmed
OBJECTIVE : To assess potential associations between Korean
Behcet ' s disease (
BD ) or other
rheumatic diseases with
vasculitis and two polymorphisms of the
endothelial nitric oxide synthase (
eNOS ) gene , which include the Glu298Asp polymorphism in exon 7 and a variable number of tandem repeats ( VNTR ) polymorphism in intron 4 . -
pubmed
Additionally ,
HLA - B51 typing was performed in the
BD group and controls by a two step PCR sequence - specific primers method . -
pubmed
Even after stratification of the
BD group based on the results of
HLA - B51 testing , a significant association of the Glu298Asp polymorphism was still found ( p=0.002 , Mantel - Haenszel weighted odds ratio 4.3 , 95 % confidence interval 1.7 to 10.9 ) . -
pubmed
Distribution of the genotype frequencies in two
eNOS gene polymorphisms was similar in
connective tissue diseases - associated
vasculitis and primary
vasculitic syndromes . -
pubmed
CONCLUSION : The Glu298Asp polymorphism in exon 7 of the
eNOS gene seems to be a susceptibility gene for Korean
BD and other
rheumatic diseases . -
pubmed
BACKGROUND : The association between sympathetic activation and mortality in chronic
heart failure and the favorable effect of beta blocking drugs has raised the possibility of therapeutic efficacy for central sympathetic inhibition with sustained - release ( SR )
moxonidine , an
imidazoline receptor agonist . -
pubmed
The use of
streptokinase - streptodornase in the treatment of
hemothorax . -
pubmed
Paraoxonase 1 and
platelet - activating factor acetylhydrolase activities in
patients with low hdl -
cholesterol levels with or without
primary hypertriglyceridemia . -
pubmed
BACKGROUND : Previous studies have shown that
high density lipoprotein ( HDL )- deficient states are associated with reduced
paraoxonase 1 (
PON1 ) activity . -
pubmed
However ,
HDL reduction caused by
primary hypertriglyceridemia has not been fully explored . -
pubmed
The aim of the present study was to evaluate whether
PON1 and
platelet - activating factor acetylhydrolase (
PAF - AH ) , two antioxidant enzymes , were altered in
patients with low
HDL -
cholesterol levels with or without
primary hypertriglyceridemia in comparison with control normolipemic subjects . -
pubmed
METHODS : We studied 24
patients with low
HDL -
cholesterol levels with ( n=12 ) or without ( n=12 )
primary hypertriglyceridemia in comparison with 12 control
subjects who presented normal
HDL -
cholesterol and
triglyceride levels . -
pubmed
PAF - AH activity was not different between
hypoalphalipoproteinemic patients and controls . -
pubmed
CONCLUSIONS : Data from this study would suggest that in
hypoalphalipoproteinemic syndrome , particularly when associated with
hypertriglyceridemia , there is impairment in enzymatic antioxidant activity exclusively related with
HDL . -
pubmed
Lymphotoxin - alpha ,
CXC ligand ( CXCL ) 12 , and
CXCL13 , key mediators of lymphoid neogenesis , were present in the CSF from
patients with
MS and other inflammatory
neurological disorders and were expressed in
MS brain tissue , with selective localization in the outer layer of the capillary vessel wall . -
pubmed
NKT cells , however , exhibited a strong
cytotoxicity when they were activated and expanded with
alpha - GalCer plus
IL-2 in vitro . -
pubmed
These results indicated that NKT cells act as regulatory cells via production of
cytokines for activation of NK cell - mediated
cytotoxicity in vivo at early phase after
alpha - GalCer administration . -
pubmed
Potent tumor - specific immunity induced by an in vivo
heat shock protein - suicide gene - based
tumor vaccine . -
pubmed
The combination of
HSP70 overexpression in situ and
tumor killing by
thymidine kinase /
ganciclovir treatment , but neither strategy alone , provoked potent systemic antitumor activities after intratumor injection of Ad - HT . -
pubmed
Tumor - specific
CD4 + and
CD8 + T - cell responses were induced by Ad - HT intratumor injection . -
pubmed
CD11c+ dendritic cells ( DCs ) isolated from
mice treated with Ad - HT were able to prime
tumor - specific CTLs . -
pubmed
Collectively , these results indicate that the combination of
tumor killing by activation of a suicide gene to release
tumor antigens and in situ
HSP70 overexpression to enhance DC antigen presentation overcomes host immune tolerance to
tumor antigens , leading to the induction of potent antitumor immunity . -
pubmed
HMMC-1 : a humanized monoclonal antibody with therapeutic potential against
Mullerian duct - related carcinomas . -
pubmed
RESULTS : HMMC-1 is a
human IgM monoclonal antibody that reacts positively with
mullerian duct - related carcinomas with positive rates of 54.6 % against
uterine endometrial adenocarcinoma , 76.9 % against
uterine cervical adenocarcinoma , and 75.0 % against
epithelial ovarian cancer . -
pubmed
HMMC-1 does not react with normal endometrium at proliferative or secretory phases ,
normal uterine cervix , or
normal and
malignant tissue from other organs , whereas it reacts weakly with the epithelium of the gall bladder and the collecting duct of the kidney . -
pubmed
The unique specificity and
cytotoxicity of
HMMC-1 strongly suggest a therapeutic potential of this antibody . -
pubmed
Adult
children ( n = 149 ) of people with
AD were randomized to one of two groups -- Intervention group : lifetime risk estimates of
AD based on age , gender , family history , and
Apolipoprotein E (
APOE ) genotype ; CONTROL GROUP : lifetime risk estimates of
AD based on the same risk factors excluding
APOE genotype . -
pubmed
New and old functions of
STAT3 : a pivotal target for individualized treatment of
cancer . -
pubmed
Recently , aberrant signaling by
STAT proteins has been demonstrated to play important roles in the pathogenesis of many
neoplasms , by promoting cell cycle progression and survival , stimulating angiogenesis , and impairing immunological responses and
tumor surveillance . -
pubmed
We have developed genetic tools to evaluate
STAT - dependent malignancy and showed that survival and growth of
lymphoid malignancies requires expression of
STAT3 . -
pubmed
While the tyrosine phosphorylation of
STAT3 , which is indicative of its signal - dependent activation , is a common occurrence in
tumors , and appears to play a crucial role in some malignancies , a variety of new data suggest that it can be dispensable under some circumstances and
STAT3 can participate in transformation through novel and non - canonical mechanisms . -
pubmed
Moreover , low doses of a
TACI fusion protein (
TACI - Fc ) that express the extracellular domain of
TACI ( amino acid [ aa ] 1 - 126 ) restored CTL priming in
B - cell - deficient mice in vivo and induced DC maturation in vitro . -
pubmed
The role of
extracellular signal - regulated protein kinase in transcriptional regulation of the
hypoxia marker
carbonic anhydrase IX . -
pubmed
In the present study , we investigated the role of the
extracellular signal - regulated protein kinase (
ERK ) in regulation of the
hypoxia marker ,
carbonic anhydrase IX (
CAIX ) . -
pubmed
U0126 , a specific inhibitor of
MEK1 / 2 , downregulated
CAIX expression induced by true
hypoxia and cell density . -
pubmed
Mapping of the
U0126 effect revealed that both critical elements within the
CA9 promoter , the
hypoxia response element and the juxtaposed
SP1 - binding
PR1 , were inhibited . -
pubmed
Constitutively increased
ERK activity in isogenic
fibrosarcoma cell lines did not cause increased cell density - dependent
CAIX expression /
CA9 promoter activity . -
pubmed
A new de novo
Notch3 mutation causing
CADASIL . -
pubmed
Here , we describe a 44 - year - old
patient with clinical features of
CADASIL who was a carrier of a new
Notch3 mutation : cys128 - ->gly . -
pubmed
This case illustrates the interest of analysing the
Notch3 gene in cases with clinical features of
CADASIL , even in the absence of a family history of the disease . -
pubmed
Glucose regulation of
CDK7 , a putative
thiol related gene , in experimental
diabetic nephropathy . -
pubmed
We previously described the identification of the 3'end of an unknown gene
CDK7 using differential display which appeared to be up - regulated in
diabetic kidneys [ R.A. -
pubmed
In the kidneys of the GK
rat , a model of
type II diabetes ,
CDK7 showed a steady age - related increase in mRNA , increasing to & gt;sixfold in 40 week GK
rats compared to normoglycemic age - matched
Wistar rat kidneys , this increase correlates with progressive
hyperglycemia . -
pubmed
Obese subjects had a higher prevalence of
iron deficiency defined by serum
iron ( 24.3 % , confidence intervals ( CI ) 19.3 - 30.2 vs 15.7 % , CI 11.0 - 21.9 % , P=0.03 ) and
transferrin receptor ( 26.9 % , CI 21.6 - 33.0 vs 15.7 % , CI 11.0 - 21.9 % , P=0.0078 ) but not by
ferritin ( 9.8 % , CI 6.6 - 14.4 vs 9.3 % , CI 5.7 - 14.7 % , P=0.99 ) . -
pubmed
The
TGFBI A546D mutation causes an atypical type of
lattice corneal dystrophy . -
pubmed
PURPOSE : To report the clinical , molecular , and histopathological features of a distinct
transforming growth factor - beta - induced (
TGFBI ) gene - linked
amyloidotic corneal dystrophy exhibiting an unusual lattice pattern . -
pubmed
CONCLUSIONS : The lattice phenotype resulting from the
TGFBI A546D mutation in this family is distinct from that observed in a previously described pedigree carrying the A546D mutation and exhibiting a phenotype designated "
polymorphic corneal amyloidosis " . -
pubmed
A pilot study of
matrix metalloproteinases on the model of
daunorubicin - induced
cardiomyopathy in
rabbits . -
pubmed
In the present study we aimed to assess the role of
MMPs in experimental
cardiomyopathy induced by repeated 10 - week administration of
daunorubicin ( 3 mg / kg i.v . ) -
pubmed
In the
daunorubicin group , the plasma cardiac
troponin T levels (
cTnT - a marker of
myocardial necrosis ) were significantly increased ( p<0.05 ) , commencing with the 8th administration compared with the controls . -
pubmed
The amount of
collagen ( an estimate of
fibrosis ) was also significantly higher in the
daunorubicin group ( 13.39 + /- 0.97 mg / g wet weight ) compared to the control group ( 10.03 + /- 0.65 mg / g wet weight ) . -
pubmed
Trastuzumab is a humanised
IgG1 monoclonal antibody , which selectively binds to the
human epidermal growth factor receptor 2 (
HER2 ) , inhibiting cell proliferation and survival in
HER2 - dependent
tumours . -
pubmed
In a randomised phase III trial in postmenopausal
women with
HER2 and
hormone receptor (
HR ) co - positive metastatic
breast cancer , median progression - free survival ( primary endpoint ) was significantly longer in
patients receiving intravenous trastuzumab plus oral
anastrozole than in those receiving
anastrozole alone . -
pubmed
In a noncomparative phase II study of trastuzumab plus
letrozole in postmenopausal
women with
HER2 and
HR co - positive metastatic
breast cancer , the majority of adverse events were mild or moderate in severity . -
pubmed
OBJECTIVE : To investigate the relationship between
muscle segment homeobox gene-1 (
MSX1 ) and the genetic susceptibility of
nonsyndromic cleft lip and palate (
NSCLP ) in Hunan Hans . -
pubmed
CONCLUSIONS :
MSX1 gene is associated with
NSCLP , and
MSX1 gene may be directly involved either in the etiology of
NSCLP or in linkage disequilibrium with disease - predisposing sites . -
pubmed
AIM : To determine whether endurance training can counterbalance the negative effects of
hypoxia on mitochondrial phosphorylation and expression of the long chain mitochondrial
fatty acid transporter muscle
carnitine palmitoyl transferase 1 (
mCPT-1 ) . -
pubmed
RESULTS : Chronic
hypoxia decreased basal ( V(0 ) , -31 % with
pamitoylCoA +
carnitine and -21 % with
palmitoylcarnitine , P & lt ; 0.05 ) and maximal ( V(max ) , -31 % with
pamitoylCoA +
carnitine , P & lt ; 0.05 ) respiration rates ,
hydroxyacylCoA dehydrogenase activity ( -48 % , P & lt ; 0.05 ) ,
mCPT-1 activity index ( -34 % , P & lt ; 0.05 ) and
mCPT-1 protein content ( -34 % , P & lt ; 0.05 ) . -
pubmed
Five weeks of endurance training in
hypoxia brought V(0 ) ,
mCPT-1 activity index and
mCPT-1 protein content values back to sedentary normoxic levels . -
pubmed
MATERIALS AND METHODS : We compared NMRI and C57Bl/6
mice , a
SSRI - sensitive strain , in the tail suspension test following
citalopram ,
paroxetine , or
fluoxetine and determined
5 - HT transporter ( 5 - HTT ) densities , 5 - HT tissue and extracellular levels ,
5 - HT synthesis ,
tryptophan hydroxylase 2 (
TPH2 ) genotypes and
hypothermia induced by the 5 - HT(1A ) agonist
8 - OH - DPAT . -
pubmed
BACKGROUND : Based on the outcome of several randomized controlled trials , the orally active
leukotriene receptor antagonist
montelukast (
Singulair , Merck ) has been licensed for treatment of
asthma . -
pubmed
Besides , we found that the 5 ' regions of
Dnmt1 and
Dnmt2 were nearly completely unmethylated in all
normal adults ,
IVF fetuses , sperm and aborted clones . -
pubmed
Association of
epidermal growth factor receptor (
EGFR ) gene mutations with
EGFR amplification in advanced
non - small cell lung cancer . -
pubmed
Somatic mutations in the
epidermal growth factor receptor (
EGFR ) gene are associated with the response to
EGFR tyrosine kinase inhibitors in
patients with
non - small cell lung cancer (
NSCLC ) . -
pubmed
However , given that it is often difficult to obtain sufficient amounts of
tumor tissue for genetic analysis from patients with advanced
NSCLC , the relationship between these two types of
EGFR alterations has remained unclear . -
pubmed
We have now evaluated
EGFR mutation status both by direct sequencing and with a high - sensitivity assay , the Scorpion - amplification - refractory mutation system , and have determined
EGFR copy number by fluorescence in situ hybridization ( FISH ) analysis in paired
tumor specimens obtained from 100 consecutive patients with advanced
NSCLC treated with chemotherapy . -
pubmed
Our results therefore suggest the existence of a significant association between
EGFR mutation and
EGFR amplification in patients with advanced
NSCLC . -
pubmed
Assessment of myocardial blood perfusion improved by
CD151 in a
pig myocardial infarction model . -
pubmed
AIM : To appraise the efficacy of
CD151 - induced myocardial therapeutic angiogenesis in a
pig myocardial infarction model . -
pubmed
CONCLUSION : This study demonstrated that the
rAAV - mediated
CD151 gene delivery promoted efficient neovascularization and increased the blood perfusion after
myocardial infarction in
pigs . -
pubmed
RESULTS : Almost half of smokers who carried a
CYP1A1 variant ( 51.3 % ) ,
GSTT1 null ( 43.6 % ) , or
GSTM1 null genotypes ( 64.1 % ) delivered a baby with
IUGR . -
pubmed
An interaction test showed increased prevalence of
IUGR in smokers with the
CYP1A1 ( Aa / aa ) variant ( adjusted OR , 1.9 ; 95 % CI , 1.4 - 5.5 , p=0.01 ) , or with the
GSTT1 null ( AOR , 1.5 ; 1.1 - 3.1 , p=0.001 ) , or
GSTM1 null genotypes ( AOR , 1.5 ; 1.2 - 3.7 , p=0.001 ) . -
pubmed
Bioluminescence and
Ki67 IHC suggested
tumor proliferation within the model . -
pubmed
The main effects of training were indicated by increased running time to exhaustion ( 80 + /- 5 and 151 + /- 13 min for groups E and TE , respectively , P = 0.0001 ) ,
myocardial hypertrophy ( 0.38 % and 0.47 % for untrained and trained
rats , respectively , P = 0.0002 ) , decreased LV ejection fraction ( 88 % and 71 % for untrained and trained
rats , respectively , P & lt ; 0.0001 ) , accelerated mitochondrial DNA 4834 - bp large deletion ( mtDNA4834 deletion ) , and up - regulated protein levels of
heat shock protein-70 ,
cytochrome C ,
cleaved capsase-3 , and cleaved
PARP in LV following a bout of exhaustive exercise . -
pubmed
Oxygen - regulated protein 150 (
ORP150 ) , also known as
grp170 , is an endoplasmic reticulum - resident
HSP and is up - regulated by
hypoxia . -
pubmed
A combination of the
VP2 and
VP3 MAbs could be used to more easily detect
TSV infections in field samples of
L. - pubmed
Complementary roles in
cancer prevention :
protease inhibitor makes the
cancer preventive peptide lunasin bioavailable . -
pubmed
TSLP protein expression was also enhanced by
RSV infection . -
pubmed
The novel
histone deacetylase inhibitor ,
AR-42 , inhibits
gp130 /
Stat3 pathway and induces apoptosis and cell cycle arrest in multiple
myeloma cells . -
pubmed
alpha - Synuclein is known to be involved in pathogenesis of a subset of
neurodegenerative diseases collectively known as
synucleinopathies . -
pubmed
Nephroblastoma overexpressed (
Nov ) induces
gremlin in
ST-2 stromal cell lines by post - transcriptional mechanisms . -
pubmed
Nephroblastoma overexpressed (
Nov ) inhibits osteoblastogenesis in part because it binds
bone morphogenetic protein ( BMP )- 2 . -
pubmed
Treatment of spleen macrophages or
HS - P cells cocultured with ILS with
cobalt chloride , which mimics the effects of
anemia - induced
hypoxia , led to downregulation of M - CSF mRNA levels , upregulation of
GM - CSF and
MIF , and an increase in phagocytic activity . -
pubmed
Estrogen receptor of
breast cancer stem cells depending on the original
breast cancers . -
pubmed
There has been arguments about the
estrogen receptor - alpha ( from this point referred to as
ER ) of
breast cancer stem cells ( BrCSCs ) . -
pubmed
We concluded that the
ER expression of BrCSCs in
ER (+ ) breast cancers is positive , while it is negative in
ER (- ) breast cancers . -
pubmed
Therefore , we hypothesize that the
ER expression of BrCSCs depends on the original
breast cancers . -
pubmed
Triple - negative
breast cancer (
TNBC ) is characterized by lack of
hormone receptors and
HER-2 and shares many features with
BRCA1 - associated
cancer . -
pubmed
Preclinical data indicate
cisplatin sensitivity , suggesting that these
tumors may have defects in the
BRCA1 pathway . -
pubmed
Granulocyte colony - stimulating factor increases the therapeutic efficacy of bone marrow mononuclear cell transplantation in
cerebral ischemia in
mice . -
pubmed
To explore this possibility , the present study examined the effect of BMMCs and
G - CSF on cell proliferation , early neuronal development and neurological function recovery in experimental
cerebral ischemia relative to controls that received neither treatment . -
pubmed
RESULT :
Ischemia /
infarct area was significantly reduced in BMMCs+
G - CSF group relative to animal groups treated with BMMCs only ,
G - CSF only or saline . -
pubmed
The results suggest that
G - CSF can increase the therapeutic efficacy of BMMCs transplantation in an experimental
mouse model of
cerebral ischemia . -
pubmed
Heme - regulated eukaryotic initiation factor 2alpha kinase (
HRI ) functions under conditions of
heme shortage caused by
blood diseases such as
erythropoietic protoporphyria and
beta - thalassemia , and retains the
heme :
globin ratio at 1:1 by sensing the
heme concentration in reticulocytes . -
pubmed
Hepatitis C virus ( HCV ) infected patients with
vasculitis are often treated with the B - cell - depleting anti -
CD20 antibody rituximab . -
pubmed
The 70 - kDa
ribosomal protein S6 kinase (
p70S6 K ) is part of the
PI3K /
AKT /
mTOR pathway and has been implicated in
cancer . -
pubmed
We included 576 subjects ( 229 controls , 193
AD , and 154
mild cognitive impairment subjects who converted to
AD ) from the ADNI study , for whom baseline data on cerebrospinal fluid
amyloid - beta (
Abeta)42 ,
phosphorylated tau ( p - tau ) , and total - tau ( t - tau ) , hippocampal volumes , and
FDG - PET were available . -
pubmed
To ensure the quality of the filter system every 7 days metabolic parametres such as WBC count ,
haemoglobin content ,
haemolysis rate ,
potassium load , pH and
ATP content were analysed over a storage period of 49 days . -
pubmed
HMGA2 elicits EMT by activating the
Wnt /
beta - catenin pathway in
gastric cancer . -
pubmed
BACKGROUND : The
high mobility group protein A2 (
HMGA2 ) is an architectural transcription factor that plays an important role in the development and progression of many
malignant neoplasms . -
pubmed
High expression of
HMGA2 in
gastric cancer correlates with invasiveness of
cancer and is an independent prognostic factor . -
pubmed
METHODS : We examined the cell biology and molecular biology changes after overexpression and knockdown
HMGA2 of
gastric cancer cells in vitro and vivo . -
pubmed
To further understand the underlying mechanisms of EMT promoted by
HMGA2 , based on our previous study , we examined the changes of target genes of
HMGA2 after overexpression and knockdown
HMGA2 of
gastric cancer cells . -
pubmed
CONCLUSIONS : The
Wnt /
beta - catenin pathway activated by
HMGA2 might be the underlying mechanism of EMT in
gastric cancer cells . -
pubmed
Gene therapy for
colorectal cancer by an oncolytic adenovirus that targets loss of the
insulin - like growth factor 2 imprinting system . -
pubmed
Loss of imprinting ( LOI ) of the
insulin - like growth factor 2 (
IGF2 ) gene is an epigenetic abnormality observed in
human colorectal neoplasms . -
pubmed
Our aim was to investigate the feasibility of using the
IGF2 imprinting system for targeted gene therapy of
colorectal cancer . -
pubmed
Slc26a4 ( Delta / Delta )
mice are deaf , develop an enlarged membranous labyrinth , and thereby largely resemble the
human phenotype where mutations of
SLC26A4 cause an
enlarged vestibular aqueduct and
sensorineural hearing loss . -
pubmed
The data suggest that the
endolymphatic enlargement caused by a loss of
Slc26a4 is a consequence of disrupted
Na (+ ) transport . -
pubmed
Activation of
orexin receptors promotes waking and is essential for expression of normal sleep and waking behaviour , with the
sleep disorder narcolepsy resulting from the absence of orexin signalling . -
pubmed
Diabetes diminishes the portal - systemic collateral vascular response to
vasopressin via
vasopressin receptor and
Galpha proteins regulations in
cirrhotic rats . -
pubmed
Diabetes diminished the portal - systemic collateral vascular response to
AVP in
rats with BDL - induced
cirrhosis , probably via
V2 receptor up - regulation and
Galpha proteins down - regulation . -
pubmed
The presence of disease - associated
prion protein in skeletal muscle of
cattle infected with classical
bovine spongiform encephalopathy . -
pubmed
The aim of this study was to investigate the presence of disease - associated
prion protein (
PrP(
Sc ) ) in the skeletal muscle of
cattle infected with classical
bovine spongiform encephalopathy (
C - BSE ) . -
pubmed
The present data indicate that small amounts of
PrP(Sc ) are detectable by immunohistochemistry in the skeletal muscles of
animals terminally affected with
C - BSE . -
pubmed
Some of these TGs were also associated with
estrogen receptor status and overall or
disease - free survival of the
patients . -
pubmed
Development of a highly sensitive and specific
blastomycosis antibody enzyme immunoassay using
Blastomyces dermatitidis surface protein BAD-1 . -
pubmed
Changes in surface expression of
N - methyl - D - aspartate receptors in the striatum in a
rat model of
Parkinson ' s disease . -
pubmed
BACKGROUND :
N - methyl - D - aspartate ( NMDA ) receptors play a central role in glutamatergic synaptic transmission in the
mammalian brain and are linked to the pathophysiology and symptomatology of
Parkinson ' s disease (
PD ) . -
pubmed
However , changes in
NMDA receptor expression in distinct subcellular compartments in
PD have not been elucidated . -
pubmed
In this study , we investigated changes in subcellular expression of
NMDA receptors in striatal neurons in a
rodent PD model . -
pubmed
RESULTS : In
PD rats where
6 - OHDA was selectively lesioned , surface expression of
NMDA receptor GluN1 subunits as detected by surface protein crosslinking assays was increased in the striatum . -
pubmed
RESULTS : Among 823 hospitalized HIV - positive adults ( median age 40 years , 58 % women ) , 24 % discovered their
HIV infection during the hospitalization , median
CD4 count was 75 / mm(3 ) ( IQR : 25 - 177 ) and 48 % had previously received antiretroviral treatment ( ART ) . -
pubmed
A series of compounds which contain
pyrazole ,
thiazole and
naphthalene ring ( 1a-7a , 1b-7b , 1c-7c , 1d-7d ) were firstly synthesized and their anti - proliferative activity ,
EGFR inhibitory activity ,
cytotoxicity and inhibition to
Hela cell migration were evaluated . -
pubmed
Detection of
immunoglobulin M ( IgM ) antibodies has long been used as an important diagnostic tool for identifying active
viral infections , but their relevance in later stages has not been clearly defined in vivo . -
pubmed
In this study , we followed the kinetics , longevity , and function of
influenza virus - specific IgM antibodies for 2 years following sublethal
infection of
mice with live
mouse - adapted
A / PR / 8 / 34 virus or immunization with
formalin - inactivated virus . -
pubmed
N -[ 3,4 - dimethoxycinnamoyl ]- anthranilic acid (
tranilast ) inhibits
transforming growth factor beta , alleviates
allergic reactions , and decreases
hypertrophic skin scars . -
pubmed
Histological evaluation of
ionized calcium binding adaptor molecule 1 (
Iba1 ) at 1 week after
SCI and
glial fibrillary acidic protein (
GFAP ) ,
fibronectin , and
chondroitin sulfate ( CS ) at week 8 was performed . -
pubmed
At week 1 after
SCI , inflammatory - cell invasion was more severe and
Iba1 expression was significantly higher in the control group . -
pubmed
METHODS : Thrombopoiesis was determined by quantification of platelet counts ,
thrombopoietin , immature platelet fraction , and mean platelet volume during
HFRS . -
pubmed
RESULTS : The levels of
thrombopoietin , immature platelet fraction , and mean platelet volume all indicate increased thrombopoiesis during
HFRS . -
pubmed
Most interestingly , we observed significantly increased in vivo platelet activation in
HFRS patients with
intravascular coagulation (
DIC and
thromboembolic complications ) as shown by
sP - selectin and
sGPVI levels . -
pubmed
Insulin dependence as an independent predictor of perioperative morbidity after
ventral hernia repair : a National Surgical Quality Improvement Program analysis of 45,759 patients . -
pubmed
The single
amino acid mutation G26R in
human apolipoprotein A - I (
apoA - IIowa ) is the first mutation that was associated with
familial AApoA1 amyloidosis . -
pubmed
The N - terminal fragments (
amino acid residues 1 - 83 ) of
apoA - I containing this mutation deposit as amyloid fibrils in
patients ' tissues and organs , but the mechanisms of cellular degradation and
cytotoxicity have not yet been clarified . -
pubmed
The
mitochondrial dysfunction caused by
apoA - IIowa fibrils depended on
cathepsin B and was ameliorated by increasing the degradation of
apoA - IIowa fibrils . -
pubmed
Our results thus provide evidence that the target of
apoA - IIowa fibrils is lysosomes , and we thereby gained a novel insight into the mechanism of
AApoA1 amyloidosis . -
pubmed
Breast cancer with an extremely high
Ki-67 labeling index despite a low nuclear grade . -
pubmed
In particular , the presence of
citrate was able to increase their
cytotoxicity and
genotoxicity , exerting also epigenotoxic effects , as evaluated by the marked reduction of
LINE-1 methylation levels . -
pubmed
OBJECTIVE :
Tofacitinib is an oral
JAK inhibitor indicated for the treatment of
rheumatoid arthritis (
RA ) . -
pubmed
Numerically , more
lymphoma cases had a history of
Sjogren ' s syndrome and were positive for
anti - cyclic citrullinated protein and
rheumatoid factor at baseline versus matched controls . -
pubmed
The DEGs could be classified in four categories :
hydrolases ( enzymes involved in various physiological functions , including digestion , immune response ,
blood coagulation , and reproduction ) , biological binding ( FMN- , actin- and metal ion - binding ) , metabolic enzymes ( e.g. -
pubmed
Role for
ERK1 / 2 - dependent activation of
FCHSD2 in
cancer cell - selective regulation of
clathrin - mediated endocytosis . -
pubmed
We recently reported that signaling can reciprocally regulate
CME in
cancer cells and that this crosstalk can contribute to
cancer progression . -
pubmed
To further explore the nature and extent of the crosstalk between signaling and
CME in
cancer cell biology , we analyzed a panel of oncogenic signaling kinase inhibitors for their effects on
CME across a panel of normal and cancerous cells . -
pubmed
Inhibition of several
kinases selectively affected
CME in
cancer cells , including inhibition of
ERK1 / 2 , which selectively inhibited
CME by decreasing the rate of
clathrin - coated pit ( CCP ) initiation . -
pubmed
Loss of
FCHSD2 activity in
nonsmall cell lung cancer (
NSCLC ) cells leads to increased cell - surface expression and altered signaling downstream of
EGFR , resulting in enhanced cell proliferation and migration . -
pubmed
The expression level of
FCHSD2 is positively correlated with higher
NSCLC patient survival rates , suggesting that
FCHSD2 can negatively affect
cancer progression . -
pubmed
Low back pain resolved and his white blood cell count and
C - reactive protein levels remained normal with the combination therapy . -
pubmed
Lactate modulates
CD4 + T - cell polarization and induces an immunosuppressive environment , which sustains
prostate carcinoma progression via
TLR8 / miR21 axis . -
pubmed
In turn , this metabolic - based CAF - immunomodulated environment exerts a pro - invasive effect on
prostate cancer cells , by activating a previously unexplored miR21 /
TLR8 axis that sustains
cancer malignancy . -
pubmed
Potential involvement of
S1PR1 /
STAT3 signaling pathway in
cardiac valve damage due to
rheumatic heart disease . -
pubmed
Th17 cell - associated
cytokines might play a role in the pathogenesis and development of
RHD , but the specific molecular mechanism is not completely understood . -
pubmed
We investigated the potential role of
sphingosine-1 - phosphate receptor 1 (
S1PR1)/
signal transducer and activator of transcription 3 (
STAT3 ) signaling pathway in
cardiac valve damage in a
rat model of
RHD . -
pubmed
The
S1PR1 /
STAT3 signaling pathway was activated in the
RHD model . -
pubmed
Compared to the control group , serum levels of
IL-17 and
IL-21 cytokines associated with Th17 cells were increased significantly in the
RHD group ; the
collagen volume fraction also was substantially increased . -
pubmed
The
S1PR1 /
STAT3 signaling pathway might be involved in
RHD induced
cardiac valve damage by regulating Th17 cells . -
pubmed
Identification of two
clip domain serine proteases involved in the
pea aphid 's defense against
bacterial and fungal infection . -
pubmed
Phenoloxidases (
POs ) are required for the
pea aphid 's defense against
bacterial and fungal infection . -
pubmed
Methylation analysis of
Gasdermin E shows great promise as a biomarker for
colorectal cancer . -
pubmed
In addition to its implication in
hereditary hearing loss , the
Gasdermin E (
GSDME ) gene is also a
tumor suppressor involved in
cancer progression through programmed cell death . -
pubmed
GSDME epigenetic silencing through methylation has been shown in some
cancer types , but studies are yet to fully explore its diagnostic / prognostic potential in
colorectal cancer on a large - scale . -
pubmed
We used public data from The Cancer Genome Atlas ( TCGA ) to investigate differences in
GSDME methylation and expression between
colorectal cancer and
normal colorectal tissue , and between left- and right - sided
colorectal cancers in 432 samples . -
pubmed
We also explored
GSDME 's diagnostic capacity as a biomarker for
colorectal cancer . -
pubmed
We observed differential methylation in all 22
GSDME CpGs between
tumor and
normal tissues , and in 18 CpGs between the left- and right - sided groups . -
pubmed
Our results suggest that
GSDME is a promising biomarker for the detection of
colorectal cancer . -
pubmed
Expression levels of
paraoxonase-1 in aortic valve tissue are associated with the progression of
calcific aortic valve stenosis . -
pubmed
Background :
Paraoxonase-1 (
PON1 ) participates in several vital steps of lipid metabolism , which is associated with
calcific aortic valve stenosis (
CAVS ) . -
pubmed
Although a few studies have suggested that
PON1 in blood could inhibit
aortic valve calcification , they did not provide detailed descriptions . -
pubmed
In this study , we hypothesized that
PON1 is expressed in the aortic valve and that the
PON1 level is related to the severity of
CAVS . -
pubmed
Conclusions : We detected
PON1 in the aortic valve for the first time , and our results suggest that the
PON1 level in aortic valve tissue decreases with increasing severity of
aortic valve stenosis . -
pubmed
Aim :
CX1003 is a novel multitargeted
receptor tyrosine kinase inhibitor targeting
cancer patients with relapsed or metastatic
malignant solid tumors . -
pubmed
Furthermore , the antioxidant activity ,
phospholipase A2 - V and
cyclooxygenases inhibitory activities of the target compounds 7a&b were evaluated and the new compounds showed potent activity (
cytotoxicity IC50 range from 4.3 to 9.2 microm , antioxidant activity from 40 % to 80 % ,
COXs or
LOX inhibitory activity from 1.92 microM to 8.21 microM ) . -
pubmed
Mitochondrial
angiotensin II receptors regulate
oxygen consumption in kidney mitochondria from healthy and
type 1 diabetic rats . -
pubmed
Exaggerated activation of the
renin angiotensin aldosterone system ( RAAS ) is a key feature in diseases such as
hypertension ,
diabetes and
chronic kidney disease . -
pubmed
Diabetes is associated with both
mitochondrial dysfunction and increased intracellular
Ang II concentration in the kidney cortex . -
pubmed
The present study investigated the role of
Ang II signaling in kidney cortex mitochondria isolated from control and
streptozotocin - induced
diabetic rats . -
pubmed
Ang II binds to only mitochondrial
AT2 receptors in control
rats and both
AT1 receptors and
AT2 receptors in
diabetic rats . -
pubmed
Ang II decreased
oxygen consumption in mitochondria from both control and
diabetic rats . -
pubmed
AT1 receptor inhibition did not affect the response to
Ang II , whereas
AT2 receptor inhibition abolished the response in mitochondria from control
animals and reversed the response to increased
oxygen consumption through
superoxide - induced mitochondrial uncoupling in mitochondria from
diabetic rat . -
pubmed
Ang II decrease mitochondrial respiration via
AT2 receptor - mediated
nitric oxide release in both control and
diabetic rats . -
pubmed
AT1 receptors do not regulate mitochondria function in control
rats , whereas
Ang II via
AT1 receptors increase mitochondria leak - respiration in
diabetic animals . -
pubmed
Many previous studies have focused on the abnormal reactions of monocytes / macrophages , neutrophils , complement system , or
cytokine inflammation in
sepsis . -
pubmed
Ribociclib (
LEE011 ,
Kisqali ) is a highly selective small molecule inhibitor of
cyclin - dependent kinases 4 and 6 (
CDK4 / 6 ) , which has been approved for the treatment of advanced or metastatic
breast cancer . -
pubmed
In the fasted and
diabetic rats phosphatase activity was less than one - half of that in fed
animals . -
pubmed
In
diabetic animals insulin also stimulated an increase in
synthase phosphatase activity but 30 min were required for full activation . -
pubmed
FOCMA is expressed on both T and B lymphoid
leukemia cells , but not expressed on non - malignant lymphoid cells , even when they are infected with
FeLV . -
pubmed
About one - third of the naturally occurring
lymphoid tumors of
cats lack detectable
FeLV proteins and varying portions of the
FeLV provirus . -
pubmed
Platelet - aggregating factor in
thrombotic thrombopenic purpura plasma . -
pubmed
Anti - D treatment in
thrombocytopenia refractory to conventional therapies . -
pubmed
We studied the cell morphology and
myeloperoxidase expression of this cell line , which was established from a
patient with
myelodysplastic syndrome who had an abnormal chromosome on the upstream region of 17p13 . -
pubmed
The results of treatment with
thyrotropin - releasing hormone (
TRH ) ,
naloxone and
dexamethasone treatments
albino rats with experimental
spinal cord injury were compared . -
pubmed
T - cell reactivity to 38 kD
insulin - secretory - granule protein in
patients with recent - onset
type 1 diabetes . -
pubmed
To see whether this reactivity is widespread at disease onset , we have generated
T - cell lines in vitro from peripheral blood mononuclear cells of nineteen
children of caucasoid origin with newly diagnosed
type 1 diabetes and sixteen healthy controls matched for age and
HLA antigens . -
pubmed
Reactivity towards the 38 kD fraction of
insulin - secretory - granule membranes was found only in
patients ( eight of ten responders tested ; 95 % CI 44 - 98 % ) and one ICA - positive
non - diabetic subject . -
pubmed
These data suggest that release of
IL-6 and
TNF - alpha may regulate lymphocyte proliferation in
HTLV - I / II - infected individuals . -
pubmed
Immunochemical characterization of circulating
parathyroid hormone - related protein in
patients with
humoral hypercalcemia of
cancer . -
pubmed
Tumors from
patients with
humoral hypercalcemia of
cancer produce a
parathyroid hormone - related protein (
PTHRP ) . -
pubmed
Patients with humoral
hypercalcemia of
cancer ( n = 30 ) had elevated levels of both
PTHRP ( 1 to 74 ) ( mean , 20.9 pmol per liter ) and
PTHRP ( 109 to 138 ) ( mean , 23.9 pmol per liter ) . -
pubmed
The plasma concentrations of immunoreactive
PTHRP correlated with the levels of urinary
cyclic AMP excreted ; in some
patients , the concentrations decreased after the
tumors were resected . -
pubmed
Patients with
chronic renal failure ( n = 15 ) had plasma
PTHRP ( 1 to 74 ) concentrations similar to those in the normal
subjects , but their plasma
PTHRP ( 109 to 138 ) concentrations were elevated ( mean , 29.6 pmol per liter ) . -
pubmed
We conclude that plasma
PTHRP concentrations are high in the majority of
patients with
cancer - associated
hypercalcemia and that the circulating forms of
PTHRP in such patients include both a large N - terminal ( 1 to 74 ) peptide and a C - terminal ( 109 to 138 ) peptide . -
pubmed
Measuring the concentrations of
PTHRPs may be useful in the differential diagnosis of
hypercalcemia . -
pubmed
Dex prevented the conjunctival
hyperemia , vascular injection and
iritis seen with endotoxin treatment alone and blocked the induction of
SOD . -
pubmed
A similar
medrysone ( med ) application ( n = 4 ) failed to prevent the visible signs of
ocular inflammation yet also blocked the elevation of
SOD . -
pubmed
The data indicate that a product of the
lipoxygenase pathway may be mediating the induction of
SOD seen with endotoxin - induced
ocular inflammation . -
pubmed
To test this hypothesis , we tested the tensile strength of femora from normal
rats and from untreated and
insulin - treated
diabetic rats two weeks after the production of a closed
fracture . -
pubmed
Treatment of the
diabetic animals with
insulin resulted in a mean concentration of serum
glucose of 14.4 + /- 0.6 millimoles per liter ( 260 + /- 10 milligrams per deciliter ) and restored the tensile strength and stiffness of the callus to a value that was not statistically different from that of the controls . -
pubmed
Between the fourth and eleventh days of healing , there was a 50 to 55 per cent decrease in the
collagen content of the callus of the untreated
diabetic animals compared with the controls . -
pubmed
Between the fourth and eleventh days of healing , the
collagen - to - DNA ratio , which was determined as an indicator of net
collagen synthesis per cell , was decreased 15 to 50 per cent in callus from the untreated
diabetic animals . -
pubmed
The effects of
Mg2 + ions or
EDTA on nuclear integrity and apparent subcellular distribution of unoccupied
oestrogen receptors in
breast cancer cells . -
pubmed
Lactate dehydrogenase isoenzymes in
leprosy patients on multi drug therapy -- a preliminary report . -
pubmed
Serum LDH ( total ) and
LDH isoenzymes were studied in
leprosy patients undergoing multidrug treatment . -
pubmed
Serum
LDH ( total ) did not show any significant difference between normal
human subjects and
patients but
LDH isoenzymes have shown elevated levels in
LDH4 and
LDH5 in
leprosy patients . -
pubmed
The effects of an
aromatase inhibitor and a
5 alpha - reductase inhibitor upon the occurrence of polyovular follicles , persistent
anovulation , and permanent vaginal stratification in
mice treated neonatally with
testosterone . -
pubmed
In order to demonstrate a suspected complement activation in
bronchial asthma , we measured the
C3d ( split product of C3 ) and the
C3d / C3 ratio in 73
adults . -
pubmed
Compared with the value obtained in 47 normal subjects , the C3d level and the
C3d / C3 ratio level were found significantly higher in
asthmatic subjects . -
pubmed
Fourteen
asthmatics presented an increased
C3d / C3 above the calculated limit of normality . -
pubmed
These 14
subjects differed from the other
asthmatics by a significantly lower
C4 plasmatic level , suggesting an activation of the classical pathway of the complement system . -
pubmed
Nevertheless , the clinical significance of these observations remains difficult to interpret in view of the absence of significant differences of clinical , allergologic and respiratory functional parameters between
asthmatics with low or high
C3d / C3 index . -
pubmed
Antibodies to the 4 - mer repeat of the
ring - infected erythrocyte surface antigen (
Pf155 /
RESA ) protect against
Plasmodium falciparum malaria . -
pubmed
To investigate the protective role of antibodies to the
ring - infected erythrocyte surface antigen (
Pf155 /
RESA ) epitopes against
Plasmodium falciparum clinical malaria , a cohort study was conducted in a Malagasy village over 7 months . -
pubmed
Because
epidermal growth factor (
EGF ) ,
transforming growth factor - alpha (
TGF - alpha ) , and
epidermal growth factor receptor (
EGFR ) have been implicated in the regulation of adrenocortical function , we used immunohistochemistry and in situ hybridization of
EGF and
TGF - alpha to study 41 specimens of
human adrenal cortex , including 10 normal specimens , 15
aldosteronomas , five
Cushing ' s adenomas , six
adrenocortical incidentalomas , and five
carcinomas to determine what role these growth factors play in controlling
human adrenocortical function . -
pubmed
TGF - alpha expression was observed in the cells with increased steroidogenesis , including compact
tumor cells and zona fasciculata cells with lipid depletion , but did not necessarily correlate with production sites of any specific
steroid hormone . -
pubmed
Both
TGF - alpha and
EGFR expression were markedly elevated in
adrenocortical carcinomas . -
pubmed
In addition ,
TGF - alpha and
EGFR may play important roles in some biological features of
adrenocortical malignancy . -
pubmed
The effect of a short treatment ( 7 days ) with the reversible
monoamine oxidase type A inhibitor
toloxatone on the reactivity to the inhalation of 35 %
CO2 was evaluated in 18
panic patients who responded to 35 %
CO2 inhalation with panic before treatment . -
pubmed
It may be concluded that
NMDA receptor blockade results in enhanced anticonvulsive action of common antiepileptics against maximal electroshock - induced
seizures . -
pubmed
Deficiency of glucose-6 - phosphate dehydrogenase (
G6PD ) is usually found at high frequencies in areas of the world where
malaria has been endemic . -
pubmed
To determine the extent of heterogeneity of
G6PD , we have studied several different Indian populations by screening for
G6PD deficiency , followed by molecular analysis of deficient alleles . -
pubmed
Remarkably , a previously unreported deficient variant ,
G6PD Orissa ( 44 Ala-->Gly ) , is responsible for most of the
G6PD deficiency in tribal Indian populations but is not found in urban populations , where most of the
G6PD deficiency is due to the
G6PD Mediterranean ( 188
Ser-->
Phe ) variant . -
pubmed
Granulocyte colony - stimulating factor recruitment of CD34 + progenitors to peripheral blood : impaired mobilization in
chronic granulomatous disease and
adenosine deaminase -- deficient severe combined immunodeficiency disease patients . -
pubmed
Peripheral blood ( PB )
CD34 + cells mobilized by
granulocyte colony - stimulating factor (
G - CSF ) administration are potentially useful for transplantation and as a target of gene transfer for therapy of
hematopoietic disorders . -
pubmed
We used this assay to assess the kinetics of
G - CSF - mediated mobilization of CD34 + cells to PB in normal
volunteers and in
patients with
chronic granulomatous disease (
CGD ) or
adenosine deaminase ( ADA )- deficient severe combined immunodeficiency disease (
SCID ) . -
pubmed
With 32 normal
volunteers mean peak
CD34 + cell counts were 57 and 76 cells / mm2 of blood ( 5 and 10 micrograms doses , respectively ) , whereas for 18
CGD patients the mean peaks were 31 and 40 cells / mm2 of blood . -
pubmed
For 2
ADA - deficient
SCID patients studied at a
G - CSF dose of 5 micrograms / kg / d , the average peak was 16 cells / mm2 of blood . -
pubmed
At days 5 and 6 ( peak mobilization of
CD34 + cells ) the mean ANC of
CGD and
ADA patients was only slightly lower ( & lt ; or = 15 % ) than that seen with normal subjects , whereas the difference in
CD34 + cell mobilization was & gt ; 48 % . -
pubmed
Finally , unexpected , but significant differences in the PB
CD34 + cell mobilization between normal subjects and
patients with
inherited disorders can occur and underscores the importance of establishing the expected mobilization of PB
CD34 + cells in the planning of treatment approaches using these cells . -
pubmed
Although the higher
MK-801 dose reduced
seizure duration by 50 % , the ECS induced
NPY - LI increase in striatum , occipital cortex and hippocampus , and
NKA - LI in occipital cortex was not diminished . -
pubmed
In contrast , there was a parallel decrease in
seizures and
NPY - LI and NKA - LI changes in frontal cortex and hippocampus , respectively . -
pubmed
Using this design , in a single diagnostic assay , we tested samples for 66
cystic fibrosis (
CF ) mutations , 14
beta - thalassemia mutations , two
sickle cell anemia (
SCA ) mutations , three
Tay - Sachs mutations , eight
Gaucher mutations , four mutations in
Canavan disease , four mutations in
Fanconi anemia , and five mutations in
BRCA1 . -
pubmed
Thus , therapy targeting
TNF and/or its
p55 receptor presents itself as a means of preventing the
osteolysis of chronic bacterial infection . -
pubmed
Bacteria and viruses produce exogenous
SAgs and those related to
food poisoning have been widely studied . -
pubmed
The presence of
parasite SAgs is still unclear and further studies are required to establish their existence and effects on the corresponding
infections . -
pubmed
Progesterone and
transforming growth factor - beta coordinately regulate suppression of endometrial
matrix metalloproteinases in a model of experimental
endometriosis . -
pubmed
Matrix metalloproteinases (
MMPs ) , enzymes which are important for extracellular matrix turnover , have recently been implicated in the development of
endometriosis . -
pubmed
Intriguingly , although
transforming growth factor - beta (
TGF - beta ) mediates
progesterone suppression of specific endometrial MMPs , this growth factor is overexpressed in
women with
endometriosis . -
pubmed
In the current study , we used an established experimental model of
endometriosis to explore
MMP regulation by
TGF - beta . -
pubmed
Our findings indicate that blocking the action of
TGF - beta opposes
progesterone - mediated suppression of
MMPs and blocks the ability of this
steroid to prevent experimental
endometriosis . -
pubmed
Taken together , our data suggest that in the absence of a normal
progesterone response , common in
ectopic lesions of
endometriosis , sensitivity to
TGF - beta may be altered , resulting in a failure to regulate
MMPs . -
pubmed
TNF receptor 1 (
TNFR1 ) and
CD95 are not required for T cell deletion after
virus infection but contribute to peptide - induced deletion under limited conditions . -
pubmed
We showed that
TNFR1 and
CD95 do not contribute to the decline of antigen - specific cytotoxic T lymphocytes after
virus infection . -
pubmed
These data indicate that
TNFR1 and
CD95 are dispensable for deletion of
antigen - specific T cells after
viral infection . -
pubmed
Dihydropyrimidine dehydrogenase activity in
human pancreatic tumor tissues . -
pubmed
Dihydropyrimidine dehydrogenase (
DPD ) activity was investigated using
pancreatic tumors and
normal pancreatic tissues surrounding the
tumors obtained from 12
patients with
pancreatic cancer . -
pubmed
The mean
DPD activity ( + /- SD ) was 2.69 + /- 1.88 nmol / mg protein / hr in
normal pancreatic tissue and was 6.59 + /- 5.36 nmol / mg protein / hr in
pancreatic tumor tissues . -
pubmed
The
DPD activity in
tumor tissue was two- to threefold higher ( p & lt ; 0.01 ) than that in normal tissue , but no marked difference was observed in
DPD activity among
cancer stages . -
pubmed
The
DPD activity of
pancreatic tumors may be a useful clinical marker of the responsibility of
fluorinated pyrimidine dosing in
pancreatic cancer . -
pubmed
Initial studies indicate that the
BMPs have neuro , cardio and reno - protective actions and it is likely that therapeutic indications for their use will extend well beyond
skeletal disease and injury . -
pubmed
Splice site mutation in the
type VII collagen gene (
COL7A1 ) in a Taiwanese family with
recessive dystrophic epidermolysis bullosa . -
pubmed
The purpose of this study was to identify mutations in
COL7A1 in one Taiwanese pedigree with generalized
RDEB . -
pubmed
Galectin-3 and
carcinoembryonic antigen expression in
medullary thyroid carcinoma : possible relation to
tumour progression . -
pubmed
We analysed the expression and coexpression of
galectin-3 and
carcinoembryonic antigen (
CEA ) , one of the putative
galectin-3 ligands , in
medullary thyroid carcinoma (
MTC ) . -
pubmed
CEA expression was found in all
tumours , distributed predominantly in the cytoplasm and occasionally at the cell surface . -
pubmed
More intense staining for
galectin-3 was mainly associated with
MTC cases involving lymph node metastases . -
pubmed
Eight out of these 10 cases showed moderate to strong
galectin-3 expression concomitant with
CEA expression throughout the
tumour tissue . -
pubmed
CONCLUSIONS : These findings suggest that
galectin-3 might play a role in the pathobiology of
MTC . -
pubmed
Simultaneous expression of
galectin-3 and
CEA in the same
tumour cells at an advanced stage of
MTC indicates the possibility of their autocrine cooperation during
tumour progression . -
pubmed
Diagnostic significance of
tau protein in cerebrospinal fluid from
patients with
corticobasal degeneration or
progressive supranuclear palsy . -
pubmed
In the present study , we assessed
tau protein levels in cerebrospinal fluids by sandwich ELISA to distinguish
CBD from
PSP . -
pubmed
The assay of
CSF tau provided diagnostic sensitivity of 81.5 % and specificity of 80.0 % between
CBD and
PSP according to receiver - operating characteristic ( ROC ) curve analysis . -
pubmed
Using data obtained from a larger number of disease cases , we confirmed our previous findings that
tau protein levels in cerebrospinal fluids in
patients with
CBD are significantly higher than those in
patients with
PSP . -
pubmed
Because
tau protein levels in cerebrospinal fluids are significantly higher in early
CBD cases than in early
PSP cases , measurement of
tau protein levels in cerberospinal fluids may be useful for the differential diagnosis of early
CBD from early
PSP . -
pubmed
Murine dlg is the homologue of the
Drosophila dlg tumor suppressor gene . -
pubmed
The loss of
dlg function in
Drosophila disrupts cellular growth control , apicobasal polarity , and cell adhesion of imaginal disc epithelial cells , resulting in
embryonic lethality . -
pubmed
Mice homozygous for the
dlg mutation exhibit
growth retardation in utero , have
hypoplasia of the premaxilla and mandible , have a
cleft secondary palate , and die perinatally . -
pubmed
OBJECTIVES : To investigate the role
substance P ( SP ) plays in
prostatic inflammation , we evaluated
SP immunoreactivity within the spinal cord after
irritation of the prostate . -
pubmed
Because alpha - adrenergic blockade attenuates nociceptor - induced
pain , the effects of an alpha - adrenergic blocker on
SP immunoreactivity were also evaluated . -
pubmed
In
dementia , the existence of a common predisposing genetic factor (
apolipoprotein E ) has already raised complex issues such as the appropriateness of genetic testing in specific clinical situations -- issues that neurologists will confront more in the future . -
pubmed
Genetic polymorphisms of the
N - acetyltransferase genes and risk of
Parkinson ' s disease . -
pubmed
Recently , the authors demonstrated linkage in
idiopathic PD to a region on chromosome 8p that contains the
N - acetyltransferase genes ,
NAT1 and
NAT2 . -
pubmed
The authors examined
NAT1 and
NAT2 for association with
PD using family - based association methods and single nucleotide polymorphisms ( SNPs ) . -
pubmed
The authors did not find evidence for association with increased risk for
PD between any individual
NAT1 or
NAT2 SNP or acetylation haplotype ( N = 397 families , 1,580 individuals ) . -
pubmed
At 3 months , she developed
hypocalcemia and
hyperphosphatemia with normal levels of
vitamin D and
alkaline phosphatase , and
parathyroid hormone level was low . -
pubmed
FLT3 ligand causes autocrine signaling in
acute myeloid leukemia cells . -
pubmed
The
FLT3 receptor tyrosine kinase is highly expressed in most
acute leukemias and frequently mutated in
acute myeloid leukemia (
AML ) . -
pubmed
The mutated form of the receptor is constitutively activated and known to play an important role in
AML , but the activation state of the
overexpressed wild - type ( wt ) receptor is , at present , unknown . -
pubmed
Coexpression of
FL with
FLT3 was a universal finding in both primary
AML samples and
leukemic - derived cell lines . -
pubmed
Taken together , these findings represent strong evidence that
wtFLT3 is often constitutively activated in
AML and thus , like its mutated form , might contribute to the altered signaling that characterizes leukemogenesis . -
pubmed
The role of
Ca ( 2 + ) ions in
tubular toxicity and the effect of
calcium channel blockers on
CsA toxicity were evaluated by measuring intracellular
calcium using the fluorescent dye
Fura-2 AM . -
pubmed
Differential
caspase expression in monocytes after
infection may contribute to
M. - pubmed
,
pigment epithelium - derived growth factor ,
PEDF ) , which may occur under ischemic conditions , may initiate the process of
retinal or choroidal neovascularization , representing a major threat to the eyesight . -
pubmed
[
Insulin pump treatment in
children and adolescents with
type 1 diabetes ] . -
pubmed
NO-1886 (
ibrolipim ) , a
lipoprotein lipase activator , increases the expression of
uncoupling protein 3 in skeletal muscle and suppresses fat accumulation in high - fat diet - induced
obesity in
rats . -
pubmed
Although the
lipoprotein lipase (
LPL ) activator
NO-1886 shows antiobesity effects in high - fat - induced
obese animals , the mechanism remains unclear . -
pubmed
Kidney disease after transplantation of a nonrenal organ has been described to be the result of the
nephrotoxicity from the commonly used
calcineurin - inhibitors as well as other factors . -
pubmed
We previously reported cloning of the
Taenia solium annexin B1 gene from a metacestode cDNA expression library and demonstrated that it acts as a protective antigen for effective vaccine development against
cysticercosis . -
pubmed
Undercoding of diagnosis was abundant in patients receiving
insulin prescriptions , as a diagnosis of
diabetes was often missing . -
pubmed
Thiazide diuretics remain primary first - step agents , especially for uncomplicated
hypertension ;
calcium channel blockers are also efficacious . -
pubmed
The
secretory phospholipase A2 group IIA : a missing link between
inflammation , activated
renin -
angiotensin system , and atherogenesis ? -
pubmed
Inflammation , lipid peroxidation and chronic activation of the
renin -
angiotensin system (
RAS ) are hallmarks of the development of
atherosclerosis . -
pubmed
Furthermore ,
sPLA ( 2 )- IIA is not only a mediator for localized
inflammation but may be also used as an independent predictor of adverse outcomes in
patients with stable
coronary artery disease or
acute coronary syndromes . -
pubmed
The role of
sPLA ( 2 )- IIA in the perpetuation of
atherosclerosis appears to be the missing link between
inflammation , activated
RAS and lipid peroxidation . -
pubmed
Plasma
adiponectin levels in
chronic kidney disease patients : relation with molecular inflammatory profile and metabolic status . -
pubmed
BACKGROUND AND AIM :
Adiponectin (
ADPN ) exerts anti - inflammatory and cardio protective effects and is associated with decreased cardiovascular risk , however its role in
patients with
chronic kidney disease is unclear . -
pubmed
METHODS AND RESULTS : We investigated the correlation between plasma
ADPN levels , the progression of
CVD and
CKD and the inflammatory gene expression profile of peripheral blood mononuclear cells in
patients from the NephroPLIC study ( a prospective study aimed at addressing the progression of
cardiovascular damage in relation to
kidney dysfunction ) . -
pubmed
CONCLUSION : In
CKD patients who are not in dialysis
ADPN plasma levels are associated with a reduced renal excretory function , but correlate inversely with the determinants of the
metabolic syndrome such as
glucose ,
triglycerides and BMI , and directly with
HDL . -
pubmed
Furthermore , in
patients with a similar degree of
renal impairment ,
ADPN plasma levels are associated with a better cardiometabolic profile , despite no significant difference being observed in the gene expression pattern of PBMC . -
pubmed
Association of
CYP7A1 -278A>C polymorphism and the response of plasma
triglyceride after dietary intervention in
dyslipidemic patients . -
pubmed
We investigated the effect of the -278A>C polymorphism in the
CYP7A1 gene on the response of plasma lipids to a reduced - fat diet for 6 to 8 weeks in a group of 82
dyslipidemic males with a mean age of 46.0 + /- 11.7 years . -
pubmed
Individuals who presented at least one high alteration in total
cholesterol ,
low - density lipoprotein cholesterol or
triglyceride values were considered to be
dyslipidemic . -
pubmed
The present study provides evidence that -278A>C polymorphism in the
CYP7A1 gene can modify
triglyceride concentrations in response to a reduced fat diet in a
dyslipidemic male population . -
pubmed
This very effective model resulted with eradication of endemic
goiter in
schoolchildren 6 - 12 - years - old , decrease of prevalence of
goiter in adults and pregnant women decrease of frequency of the elevated
TSH concentration in neonates blood and decrease of dynamic of increasing an incidence rate of differentiated
thyroid cancer and its follicular fraction . -
pubmed
Effects of
donepezil on
amyloid - beta and synapse density in the Tg2576
mouse model of
Alzheimer ' s disease . -
pubmed
Donepezil , an
acetylcholinesterase inhibitor , is an approved drug for the treatment of
Alzheimer ' s disease (
AD ) . -
pubmed
These results suggest that a higher dose of
donepezil may have a measurable impact on tissue level of
Abeta protein and plaque deposition and may prevent synapse loss in the Tg2576
mouse model of
AD . -
pubmed
Syndromic features and mild
cognitive impairment in
mice with genetic reduction on
p300 activity : Differential contribution of
p300 and
CBP to
Rubinstein - Taybi syndrome etiology . -
pubmed
A majority of the
individuals diagnosed with
RSTS carry heterozygous mutation in the gene
CREBBP , but a small percentage of cases are caused by mutations in
EP300 . -
pubmed
To investigate the contribution of
p300 to
RSTS pathoetiology , we carried out a comprehensive and multidisciplinary characterization of
p300(+/- )
mice . -
pubmed
These analyses demonstrate that
p300(+/- )
mice exhibit phenotypes that are reminiscent of neurological traits observed in
RSTS patients , but their comparison with previous studies on
CBP deficient strains also indicates that , in agreement with the most recent findings in
human patients , the activity of
p300 in cognition is likely less relevant or more susceptible to compensation than the activity of
CBP . -
pubmed
DNA methylation status of the
IL8 gene promoter in aggressive
periodontitis . -
pubmed
BACKGROUND : Studies evaluating the methylation status of cytokine genes may have relevance for
inflammatory diseases in which the expression of some
cytokines is altered , such as
periodontitis . -
pubmed
Tuberous sclerosis , caused by germline mutations in the
TSC1 or
TSC2 genes , is associated with aberrant upregulation of the
mammalian target of rapamycin (
mTOR ) signalling pathway , resulting in growth of
tumours , including
renal angiomyolipomas (
AMLs ) . -
pubmed
More recently ,
mTOR inhibitors have been used as molecularly targeted treatment to treat
AMLs . -
pubmed
Dynamin GTPase regulation is altered by PH domain mutations found in
centronuclear myopathy patients . -
pubmed
Here , we describe studies of
dynamin PH domain mutations found in
centronuclear myopathy (
CNM ) that increase
dynamin 's
GTPase activity without altering
phosphoinositide binding . -
pubmed
Clinical significance of serum anti -
annexin V antibodies in Egyptian
patients with
scleroderma . -
pubmed
We investigated the prevalence of anti -
annexin V IgG and
IgM antibodies in sera of
scleroderma patients and their relation to the presence of other antibodies and development of disease morbidity . -
pubmed
Sera of 40
scleroderma patients and 15 healthy controls were examined for
IgG and
IgM anti - annexin V antibodies by ELISA and anticentromere antibodies by indirect immunofluorescence . -
pubmed
Serum level of anti -
annexin V IgG antibodies in
scleroderma patients was significantly higher than that of the control ( P & lt ; 0.001 ) and correlated significantly with the presence of
digital ischemia ( P = 0.023 ) and
pulmonary fibrosis ( P = 0.02 ) . -
pubmed
In conclusion , measurement of serum anti -
annexin V IgG antibodies in
scleroderma patients may be important for early diagnosis of
vascular and pulmonary complications . -
pubmed
Efficacy of
L - asparaginase with
methotrexate and
dexamethasone (
AspaMetDex regimen ) in
patients with refractory or relapsing
extranodal NK / T - cell lymphoma , a phase 2 study . -
pubmed
Potent antifibrotic activity of
mTOR inhibitors
sirolimus and
everolimus but not of
cyclosporine A and
tacrolimus in experimental
liver fibrosis . -
pubmed
RESULTS :
Sirolimus and
everolimus decreased
fibrosis up to 70 % , improved portal pressure , reduced
ascites , and showed potent down - regulation of pro - fibrogenic genes , paralleled by a strong increase in matrix degradation (
collagenase ) activity ; in contrast ,
tacrolimus and
cyclosporine A had no or even aggravating effects on
liver fibrosis in
rats . -
pubmed
CONCLUSIONS :
mTOR inhibition by
sirolimus and
everolimus in experimental
liver fibrosis associates with significantly less
fibrosis progression and portal
hypertension than treatment with
calcineurin inhibitors
tacrolimus and
cyclosporine A. -
pubmed
OBJECTIVES : We examined the relationship between
glycosylated hemoglobin (
HbA1c ) level and coronary flow rate in
patients with
type 2 diabetes mellitus (
DM ) and angiographically normal coronary arteries . -
pubmed
The incidence of
SCF was significantly greater in
patients with
HbA1c & gt;=7.0 % than those with
HbA1c & lt;7.0 % ( 96.4 % vs. 61.5 % ; p=0.004 ) . -
pubmed
Talin-1 overexpression defines high risk for aggressive
oral squamous cell carcinoma and promotes
cancer metastasis . -
pubmed
IHC analyses and
mouse study also revealed an association between
TLN1 overexpression and advanced
OSCC with invasion to adjacent tissues . -
pubmed
The present study suggests an important role for
TLN1 in
oral cancer development . -
pubmed
TLN1 overexpression could serve as a diagnostic marker for aggressive phenotypes and a potential target for treating
OSCC . -
pubmed
STIM and
Orai in hemostasis and
thrombosis . -
pubmed
Doxycycline stabilizes vulnerable plaque via inhibiting
matrix metalloproteinases and attenuating
inflammation in
rabbits . -
pubmed
Enhanced
matrix metalloproteinases (
MMPs ) activity is implicated in the process of
atherosclerotic plaque instability . -
pubmed
We hypothesized that
doxycycline , a broad
MMPs inhibitor , was as effective as
simvastatin in reducing the incidence of
plaque disruption . -
pubmed
The results showed that oral administration of
doxycycline resulted in a significant increase in the thickness of the fibrous cap of the aortic plaque whereas there was a substantial reduction of
MMPs expression , local and systemic
inflammation , and
aortic plaque vulnerability . -
pubmed
In conclusion ,
doxycycline at a common antimicrobial dose stabilizes
atherosclerotic lesions via inhibiting
matrix metalloproteinases and attenuating
inflammation in a
rabbit model of vulnerable
plaque . -
pubmed
Therapeutic effect of
ghrelin in experimental
autoimmune encephalomyelitis by inhibiting antigen - specific Th1 / Th17 responses and inducing regulatory T cells . -
pubmed
A short systemic treatment with
ghrelin after the disease onset reduced clinical severity and incidence of both forms of
EAE , which was associated with a decrease in inflammatory infiltrates in spinal cord and in the subsequent demyelination . -
pubmed
Elevated circulating
cytotoxic T lymphocyte - associated antigen-4 levels are related to lung function and
inflammation in
chronic obstructive pulmonary disease . -
pubmed
The present study aimed to investigate the association between
CTLA-4 and
COPD . -
pubmed
Data revealed that serum levels of
CTLA-4 were elevated in
COPD patients , inversely correlated with lung function and positively correlated with serum
C - reactive protein levels in the
COPD group . -
pubmed
These findings suggest that
CTLA-4 may play a role in
COPD . -
pubmed
Our results indicated that 11 ( 10 % )
patients experienced incidents of
hypoglycaemia ranging from 1.8 to 3.9 mmol / l. None of the individuals affected had received intravenous or subcutaneous
insulin . -
pubmed
Together these results suggest that re - activation of
p53 may be a possible means for eradicating extrachromosomal
HPV16 , 18 or 31 genomes in the context of persistent
infections . -
pubmed
In contrast to geriatric scales , we found history of
cardiovascular diseases to be strongly associated for this parameter as for high
IL-6 production upon ex vivo stimulation with alum . -
pubmed
CHARGE syndrome is a complex
genetic syndrome , owing to the wide range of tissues / systems affected by mutations in the
CHD7 gene . -
pubmed
OBJECTIVES : The aim of this study was to evaluate the efficacy and safety of rituximab and tocilizumab compared with adalimumab ,
etanercept , and infliximab , in
patients with
rheumatoid arthritis not responding to first - line treatment , and to compare the efficacy and safety of rituximab versus tocilizumab in
patients not responding to anti -
tumor necrosis factor alpha ( anti -
TNF ) therapy . -
pubmed
KRAS mutation testing of
tumours in adults with metastatic
colorectal cancer : a systematic review and cost - effectiveness analysis . -
pubmed
Kirsten rat sarcoma viral oncogene (
KRAS ) mutations make some
tumours less responsive to treatment with biological therapies such as cetuximab . -
pubmed
OBJECTIVES : To compare the performance and cost - effectiveness of
KRAS mutation tests in differentiating adults with metastatic
colorectal cancer whose
metastases are confined to the liver and are unresectable and who may benefit from first - line treatment with cetuximab in combination with standard chemotherapy from those who should receive standard chemotherapy alone . -
pubmed
Four RCTs provided data on the clinical effectiveness of cetuximab plus standard chemotherapy compared with that of standard chemotherapy in patients with
KRAS wild - type
tumours . -
pubmed
METHODS :
Anti - Saccharomyces cerevisiae antibody immunoglobulin ( Ig ) A and
immunoglobulin G titres , paediatric
Crohn ' s disease activity index ( PCDAI ) ,
serum albumin and
C - reactive protein (
CRP ) were repeatedly measured simultaneously in
children with
Crohn ' s disease . -
pubmed
RESULTS : Serial 136 measurements of
ASCA IgA and
IgG titres were documented in 57
children with
Crohn ' s disease over a mean duration of 3.1 + - 2.1 years . -
pubmed
CONCLUSION : Both
ASCA IgA and
IgG titres seemed to correlate well with clinical
Crohn ' s disease activity in children . -
pubmed
MATERIAL AND METHODS : We carried out univariate and multivariate analyses in an attempt to establish statistically significant preoperative ( age , rectal examination ,
PSA , biopsy Gleason score , uni / bilateral
tumor , affected cylinder percentage ) and postoperative ( pT stage , pN lymph node affectation , Gleason score , positive surgical margins , percentage of
tumor affectation , perineural infiltration ) risk factors , as well as their relationship with biochemical recurrence (
PSA & gt;0.2 ng / mL ) . -
pubmed
At presentation , patients of the
BCSH group showed significantly higher values of serum
lactate dehydrogenase and had palpable
splenomegaly more frequently . -
pubmed
OBJECTIVES : To evaluate the relevance of anti - adalimumab ( anti -
ADA ) antibodies ( Abs ) and their relationship with clinical / laboratory features in
rheumatoid arthritis (
RA ) ,
ankylosing spondylitis (
AS ) and
psoriatic arthritis (
PsA ) . -
pubmed
Placenta growth factor and
neuropilin-1 collaborate in promoting
melanoma aggressiveness . -
pubmed
In
melanoma models ,
PlGF enhances
tumour growth and neovessel formation , whereas
NRP-1 promotes the metastatic process . -
pubmed
In this study we investigated whether
PlGF and
NRP-1 cooperate in promoting
melanoma aggressiveness independently of
VEGFR-1 . -
pubmed
We also compared the levels of
PlGF in the plasma of
patients affected by
metastatic melanoma with those of healthy donors and evaluated whether
PlGF levels could be affected by a bevacizumab - containing chemotherapy regimen . -
pubmed
Melanoma patients showed a 20 - fold increase in plasma
PlGF and the bevacizumab - containing regimen induced a reduction of
VEGF - A and in a further increase of
PlGF . -
pubmed
In conclusion , our studies suggest that the activation of
NRP-1 by
PlGF directly contributes to
melanoma aggressiveness and represents a potential compensatory pro - angiogenic mechanism that may contribute to the resistance to therapies targeting
VEGF - A. -
pubmed
In this study , therefore , we investigated whether non - viral anti -
thymidylate synthase RNAi embedded liposome ( TS shRNA lipoplex ) would effectively guide the downregulation of
TS in
human malignant mesothelioma MSTO-211H cells . -
pubmed
Expression changes of
C - myc ,
Apaf-1 ,
caspase-3 ,
interleukin ( IL )- 6 , and
IL-17 during the protection against
UC injury through chemical stimulation of the PVN in
rats were detected by Western blot . -
pubmed
After chemical stimulation of the PVN ,
SOD activity increased ,
MDA content decreased ,
C - myc protein expression significantly increased ,
caspase-3 and
Apaf-1 protein expression significantly decreased , and
IL-6 and
IL-17 expression decreased in colon tissues in
rats with
UC . -
pubmed
In the vaccination model against
caries , LIVE system allowed the heterologous expression of
Streptococcus mutans antigen
GbpB by
L. - pubmed
Nonamplification
ERBB2 genomic alterations in 5605 cases of recurrent and metastatic
breast cancer : An emerging opportunity for anti -
HER2 targeted therapies . -
pubmed
The authors queried 5605 advanced / metastatic
breast cancers (
mBC ) to uncover the frequency of
ERBB2mut genomic alterations . -
pubmed
Both primary
BC ( 52 cases ; 38 % ) and metastatic site biopsies ( 86 cases ; 62 % ) were found to harbor
ERBB2mut , which were distributed across
carcinoma not otherwise specified ( NOS ) ( 69 cases ; 50 % ) , invasive ductal
carcinoma (
IDC ) ( 40 cases ; 29 % ) ,
invasive lobular carcinoma (
ILC ) ( 27 cases ; 20 % ) , and
mucinous mBC ( 2 cases ; 1 % ) . -
pubmed
CDH1 mutations were enriched in
ERBB2mut mBC ( P<0.0006 ) and associated with recurrent
mBC . -
pubmed
Metastatic
BC driven by
ERBB2mut respond to anti -
HER2 targeted therapies , and expanding clinical trials designed to detect
ERBB2mut by CGP and optimize targeted treatments are warranted . -
pubmed
Momelotinib in
myelofibrosis :
JAK1 / 2 inhibitor with a role in treating and understanding the
anemia . -
pubmed
Myelofibrosis (
MF ) is a chronic malignancy of the blood - forming system caused by hyperactivation of
JAK2 /
STAT signaling pathway . -
pubmed
Small - molecule inhibitors of
JAK2 can variably ameliorate
MF - related symptoms caused by
chronic inflammation and
hepatosplenomegaly . -
pubmed
Anemia is a significant problem and adverse prognostic factor in over a third of
MF patients and is often worsened by
JAK2 inhibitors . -
pubmed
The
JAK1 / 2 inhibitor
momelotinib unexpectedly resulted in reduction of
anemia in
MF patients during Phase I / II trials . -
pubmed
Our data indicate that activation of the
renin -
angiotensin system through excessive administration of loop - diuretics is associated with a risk of
hypovolemia and thus drug - induced
hypotension that deserves special attention when considering converting enzyme inhibitor therapy in
congestive heart failure . -
pubmed
ERCC1 and
ERCC2 as predictive biomarkers to
oxaliplatin - based chemotherapy in
colorectal cancer patients from Egypt . -
pubmed
METHODS : The study included 80
CRC patients who received first line
oxaliplatin based chemotherapy The expression levels of
ERCC1 and
ERCC2 - mRNA and proteins were determined in the primary
tumors by quantitative real time reverse transcription polymerase chain reaction(RT - qPCR ) and immunohistochemistry ( IHC ) ; respectively . -
pubmed
In multivariate analysis performance status ( PS ) , stage of the
disease and
ERCC1 - mRNA expression were independent prognostic factors for EFS whereas
tumor histology and stage of the disease were independent factors for OS . -
pubmed
CONCLUSIONS :
ERCC1 expression levels may help in selecting patients who benefit from
oxaliplatin chemotherapy in stage III & amp ; IV
CRC . -
pubmed
Vitamin D across
growth hormone ( GH ) disorders : From
GH deficiency to
GH excess . -
pubmed
In addition , data on the impact of
GH treatment on
vitamin D levels in
GHD patients are quite conflicting . -
pubmed
Conversely , in active
acromegaly , a condition characterized by a chronic
GH excess , both increased and decreased
vitamin D levels have been highlighted , and the interplay between
vitamin D and the
GH / IGF - I axis becomes even more complicated when we consider the
acromegaly treatment , both medical and surgical . -
pubmed
De Novo Disruption of the Proteasome Regulatory Subunit
PSMD12 Causes a
Syndromic Neurodevelopmental Disorder . -
pubmed
Adipose
angiotensin II type 1 receptor - associated protein ameliorates
metabolic disorders via promoting adipose tissue adipogenesis and browning . -
pubmed
Our data revealed that adipose
ATRAP plays an important role in preventing
metabolic disorders and
adiponectin possibly mediates the effects of adipose
ATRAP . -
pubmed
METHODS : Genetic analyses of
patients with
FH were conducted for
LDL - receptor ,
PCSK9 , and
ApoB100 . -
pubmed
A significant inverse correlation was found between
LDL - C levels and LS ( P & lt ; .001 , r = .728 ) and CS ( P & lt ; .001 , r = .642 ) for all
FH patients . -
pubmed
Nanoparticle
albumin - bound
paclitaxel and
gemcitabine ( nab - P / G ) is an evidence - based treatment for
patients with
APC . -
pubmed
ABBREVIATIONS : AbTG : Anti -
thyroglobulin antibodies ; AbTPO : Anti - peroxydase antibodies ;
AML :
Acute myeloid leukemia ;
APRIL : A
proliferating - inducing ligand ;
BAFF :
B - cell activating factor ; CAPA : Canadian
Arthritis Patient Alliance ; CI : Confidence interval ;
CIN :
Cervical intraepithelial neoplasia ; CT : Computed tomography ;
DLBCL :
Diffuse large B cell lymphoma ; dsDNA : Double - stranded DNA ;
EBV :
Epstein - Barr virus ; EULAR European League Against
Rheumatism ;
IBD :
Inflammatory bowel disease ;
HBV :
Hepatitis B virus ;
HCV :
Hepatitis C virus ;
HIV :
Human immunodeficiency virus ; HR : Hazard ratio ;
HSIL :
High - grade cervical squamous intraepithelial lesions ; HSV :
Herpes simplex virus ;
HL :
Hodgkin lymphoma ;
HPV :
Human papillomavirus ;
MALT : Mucosa - associated lymphoid tissue ;
MDS :
Myelodysplastic syndrome ;
MESNA :
2 - mercaptoethane sodium sulfonate ;
NHL :
Non - Hodgkin lymphoma ; OR : Odds ratio ; Pap : Papanicolaou ;
RA :
Rheumatoid arthritis ;
SLE :
Systemic Lupus erythematous ;
SLICC : Systemic International Collaborating Clinics ; SNPs : Single - nucleotide polymorphisms ; SOGC : Society of Obstetricians and Gynaecologists of Canada . -
pubmed
Preoperative Th1 / Th2 and related
cytokines : Prediction value in postoperative febrile
UTI after ureteroscopy in
patients with
ureteral calculi . -
pubmed
OBJECTIVES : The objective of this study was to investigate the role of preoperative Th1 / Th2 cells and related
cytokines in the prediction of postoperative
febrile UTI after ureteroscopy in
patients with
ureteral calculi . -
pubmed
RESULTS : Compared with
patients in non -
UTI group , those in febrile
UTI group had significantly increased proportions of Th2 cells , levels of Th2
cytokines (
interleukin ( IL )- 4 ,
IL-10 and
IL-5 ) , and mRNA expression of
Th2 - associated transcription factor GATA3 ( all p & lt ; 0.05 ) . -
pubmed
Receiver operating characteristic ( ROC ) curve analysis showed that the accuracy rate of Th2 % , Th1 / Th2 ratio , and
IL-4 ,
IL-10 and
IL-5 levels for the diagnosis of postoperative
febrile UTI in
patients with
ureteral calculi was 90.63 % , 85.00 % , 72.50 % , 87.50 % , and 91.88 % , respectively , and their combined diagnostic sensitivity was 97.4 % with specificity as high as 100 % . -
pubmed
INTRODUCTION : Once - weekly semaglutide is a novel
glucagon - like peptide-1 (
GLP-1 ) analogue for the treatment of
type 2 diabetes that was associated with greater reductions in
glycated hemoglobin (
HbA1c ) and body mass index ( BMI ) versus once - daily
GLP-1 analogue liraglutide in a recent network meta - analysis ( NMA ) . -
pubmed
Here , immunohistochemistry of
CYP11B1 and
B2 was used to investigate whether these markers could aid in the diagnostic workup of
primary aldosteronism patients . -
pubmed
The
hyperplasia diagnosis was suggested when there was no dominating nodule but immunoreactivity for
CYP11B2 was seen in several nodules , which were also seen on routine sections . -
pubmed
To distinguish between
adenoma and
hyperplasia , a ratio between the largest and second largest
CYP11B2 - positive nodules was calculated . -
pubmed
CONCLUSION : : Immunohistochemistry detecting
CYP11B1 and
B2 expression is of great help in establishing a final histopathological diagnosis in
patients with
primary aldosteronism . -
pubmed
In this study , a strategy was proposed to utilize
type II collagen (
Col - II ) gels with autologous bone marrow - derived cells ( BMDCs ) embedded to repair
full - thickness chondral defects . -
pubmed
Midbrain - specific organoids derived from
PD patients carrying the
LRRK2 - G2019S mutation recapitulate disease - relevant phenotypes . -
pubmed
The floor plate marker
FOXA2 , required for mDAN generation , increases in
PD patient - derived midbrain organoids , suggesting a
neurodevelopmental defect in mDANs expressing
LRRK2 - G2019S. -
pubmed
Expression of
PD-1 /
PD - L1 in primary
breast tumours and metastatic axillary lymph nodes and its correlation with clinicopathological parameters . -
pubmed
The aim of this study was to compare the expression of
PD-1 /
PD - L1 in primary
breast tumours to that in metastatic axillary lymph nodes and to determine the correlation between the
PD-1 /
PD - L1 status and clinicopathologic characteristics . -
pubmed
Significant differences in
PD - L1 expression were observed between primary breast
tumours and paired axillary lymph nodes . -
pubmed
Since heterogeneity exists , it is necessary to determine the
PD - L1 status in both the primary
tumour and metastatic lymph nodes . -
pubmed
Farnesoid X receptor (
FXR)-agonists have been approved und used in other
liver diseases , such as
primary biliary cholangitis (
PBC ) and
primary sclerosing cholangitis (
PSC ) , and have shown signs of being able to decrease
inflammation and potentially
steatosis . -
pubmed
The results indicated that
PRP could improve
wound healing process of deep partial - thickness
burns in Bama
pigs . -
pubmed
We demonstrated that applying
PRP had a greater potential for the treatment of deep partial - thickness
burns . -
pubmed
In this study , we hypothesized that
heme oxygenase-1 (
HO-1 ) , an enzyme responsible for degradation of
heme to
carbon monoxide (
CO ) ,
bilirubin , and
iron is an important regulator of
inflammation and epithelial responses in the prostate . -
pubmed
coli infection in macrophages and was in part required for
IL-1beta expression and
prostate cancer cell colony growth in soft agar . -
pubmed
In summary , these results suggest that
HO-1 / CO might play a distinctive role in modulating
prostate inflammation , cell proliferation and
IL-1beta induction in part via an
ACSL1 - mediated pathway . -
pubmed
LncRNA
CTBP1 -
AS2 sponges miR-216a to upregulate
PTEN and suppress
endometrial cancer cell invasion and migration . -
pubmed
BACKGROUND : Although lncRNA
CTBP1 -
AS2 has been functionally analyzed only in cardiomyocyte
hypertrophy and
diabetes , analysis of TCGA dataset revealed its downregulation in endometrial
carcinoma (
EC ) , indicating its involvement in
EC . -
pubmed
RESULTS : In this study we found that
CTBP1 -
AS2 was downregulated in
EC and correlated with poor survival . -
pubmed
Transwell assay showed that
CTBP1 -
AS2 and
PTEN overexpression led to decreased
cancer cell invasion and migration and reduced enhancing effects of miR-216a on cell invasion and migration . -
pubmed
CONCLUSION : Therefore ,
CTBP1 -
AS2 may sponge miR-216a to upregulate
PTEN , thereby suppressing
endometrial cancer cell invasion and migration . -
pubmed
Directly impacting NK cell function ,
KIR polymorphism associates with
infection control and multiple
autoimmune and pregnancy syndromes . -
pubmed
The
KCNJ2 gene mutations induce
short QT syndrome ( SQT3 ) by directly increasing the I K1 current . -
pubmed
However , the
KCNJ2 E299V mutation is distinguished from other representative gene mutations that can induce the
short QT syndrome (
SQT3 ) in that it increased I K1 current by impairing the inward rectification of K+ channels . -
pubmed
Therefore , we investigated the electrophysiological changes and the concomitant mechanical responses according to the expression levels of the
KCNJ2 E299V mutation during sinus rhythm and
ventricular fibrillation . -
pubmed
We concluded that in both sinus rhythm and
fibrillation , the
KCNJ2 E299V mutation results in very low contractility regardless of the expression level of mutation and increases the risk of
cardiac arrest and
cardiac death . -
pubmed
DISCOVERY : prevalence of
transthyretin (
TTR ) mutations in a US - centric patient population suspected of having
cardiac amyloidosis . -
pubmed
Methods : DISCOVERY , a multicenter screening study , enrolled patients with clinically suspected
cardiac amyloidosis to determine the frequency of
transthyretin (
TTR ) mutations and assess disease characteristics . -
pubmed
Conclusions : Pathogenic
TTR mutations occurred in 8 % of US patients with suspected
cardiac amyloidosis . -
pubmed
The results revealed that GelMA / HA - DA / GO - betaCD - BNN6 was an ideal antibacterial material that improved
collagen deposition and angiogenesis and promoted
wound healing in a
mouse model of full thickness skin repair , compared with the commercially - available Aquacel
Ag dressing . -
pubmed
Cutaneous
HPV16 and
p16 Positive
Basaloid Squamous Cell Carcinoma with
Brain Metastasis : A Case Report . -
pubmed
In contrast , oncogenic
human papillomavirus and
p16 are screened in
head and neck squamous cell carcinoma for prognostication . -
pubmed
P16 , a surrogate marker for
human papillomavirus infection and specifically
HPV16 was identified in the
tumor . -
pubmed
circRNA
RNF111 regulates the growth , migration and invasion of
gastric cancer cells by binding to miR-27b-3p . -
pubmed
hsa_circ_0001982 [
circRNA ring finger protein 111 (
RNF111 ) ] has been found to promote
cancer growth ; however , its role in
gastric cancer (
GC ) remains unclear . -
pubmed
The present study examined the effects of
circR -
RNF111 on the growth , migration and invasion of
GC cells and aimed to elucidate the underlying molecular mechanisms . -
pubmed
The expression levels of
circR -
RNF111 and miR-27b-3p in
GC tissues and
GC cell lines were detected by reverse transcription - quantitative PCR ( RT - qPCR ) . -
pubmed
The effects of circR -
RNF111 and miR-27b-3p on cell growth , apoptosis , migration and invasion were detected by cell counting kit-8 ( CCK-8 ) assay , colony formation assay , flow cytometry ,
wound - healing assay and Transwell assay , respectively . -
pubmed
The results revealed that
circR -
RNF111 and miR-27b-3p were closely related to the clinicopathological characteristics of
GC , and that
circR -
RNF111 and miR-27b-3p negatively correlated and were abnormally expressed in
GC . -
pubmed
Furthermore , miR-27b-3p inhibition reversed the regulatory effects of
circR -
RNF111 silencing on the
GC cells . -
pubmed
On the whole , the findings of the present study demonstrate that
circR -
RNF111 is involved in the regulation of growth , migration and invasion of
GC cells by binding to miR-27b-3p . -
pubmed
Role of
Chrysophanol in Epithelial - Mesenchymal Transition in
Oral Cancer Cell Lines via a
Wnt-3 - Dependent Pathway . -
pubmed
Immunoglobulin M for
dengue was confirmed and second - degree
atrioventricular block Mobitz I with
bradycardia ( 40 beats / minute ) was documented throughout the clinical course . -
pubmed
CONCLUSIONS :
SLC2A3 and
MAN2A1 may be important genes for the pathogenesis of
CTEPH . -
pubmed
BACKGROUND : Transition to
dolutegravir - based regimens in resource - limited settings (
RLS ) requires prior understanding of
HIV-1 integrase variants and conserved regions . -
pubmed
Selected
rabbit antisera to
cholera toxin antigens and convalescent
cholera patient sera were analyzed using the permeability factor neutralization test and two sensitive in vitro serological assays specific for
cholera toxin ,
cholera toxin A subunit , and
cholera toxin B subunit . -
pubmed
F(ab')2 fragments purified from selected positive and negative
MS and control sera gave no staining , though
IgG fractions from the same sera prior to
pepsin digestion gave positive staining . -
pubmed
These results indicate that oligodendrocyte staining is not specific for
MS , is not due to specific antibody , and is probably the result of nonspecific binding to
Fc receptors . -
pubmed
In spite of significantly higher serum
insulin levels the t 1/2 Leu in
patients with
cirrhosis of the liver was significantly prolonged compared with healthy controls after
leucine administration as well after
leucine and
glucose administration . -
pubmed
Therefore we conclude , that in
patients with
cirrhosis of the liver in spite of elevated serum
insulin levels
leucine as well as
glucose are metabolized slower . -
pubmed
[ Immunocytes and
immunoglobulins of the digestive tract during primary
immune deficiencies in adults . -
pubmed
The 5 groups were ( a ) healthy non -
diabetic subjects not exposed to vibration ( n = 10 , mean age 52.3 yrs ) ( b ) 2
insulin dependent and 8 non -
insulin dependent
diabetic subjects with a mean of 6 years treatment ( n = 10 , mean age 55.7 yrs ) ( c ) maintenance
employees exposed to high frequency pneumatic hand tools ( n = 10 , mean age 52.2 yrs ) ( d ) subjects who were not
diabetic or exposed to vibrating tools , but were being treated with the
ACE - inhibitor enalapril 20 mg daily for
hypertension ( n = 5 , mean age 54 yrs ) ( e ) subjects who had smoked more than 10 cigarettes daily for at least 15 yrs ( n = 10 , mean age 51 yrs ) . -
pubmed
Improvements were made in the immunodetection of anti - galactocerebroside (
anti - GalC ) antibody in sera of
patients with
human African
trypanosomiasis by thin - layer chromatography , enzyme - linked immunosorbent assay , and immunoadsorption . -
pubmed
Anti - GalC antibodies were found in the sera of 42.8 % of 63
patients with
human African trypanosomiasis . -
pubmed
Anti -
GalC levels were higher in
human African
trypanosomiasis patients with
neurologic disturbances compared with patients without such disturbances . -
pubmed
These antibodies were distributed mainly between the
IgG and
IgM classes , but 28 % of the
patients with
human African trypanosomiasis had increased
IgA levels without
anti - GalC antibody activity . -
pubmed
Mucin positivity as well as immunoreactivity for
epithelial membrane and carcinoembryonic antigens were confined to metastatic
adenocarcinoma in this case , whereas
Ki-1 and
alpha - fetoprotein immunostaining were restricted to the ten control cases of
germ cell tumors . -
pubmed
Immunologic measurements of the serum concentration of
prostate - specific antigen (
PSA ) , an abundant
prostatic - secreted serine proteinase , are frequently used to monitor
patients with
prostate cancer , though it has not been ascertained whether this immunoreactivity represents a
PSA zymogen , the active
proteinase , or
PSA complexed to
extracellular proteinase inhibitors . -
pubmed
Normovolemic
hemodilution under normoxic conditions ( arterial
oxygen partial pressure normal ) at rest is limited by the critical arterial
oxygen content of about 10 ml / dl corresponding to a
hemoglobin concentration of 7.5 g / dl . -
pubmed
Recombinant
human DNase I reduces the viscosity of
cystic fibrosis sputum . -
pubmed
To evaluate the potential clinical utility of recombinant
human DNase I (
rhDNase ) in the treatment of
cystic fibrosis , we have cloned , sequenced , and expressed
rhDNase . -
pubmed
Catalytic amounts of
rhDNase greatly reduce the viscosity of
purulent cystic fibrosis sputum , transforming it within minutes from a nonflowing viscous gel to a flowing liquid . -
pubmed
Inhalation of a
rhDNase aerosol may be a simple direct approach that will help individuals with
cystic fibrosis and other patients with
pneumonia or
bronchitis to clear their airways of purulent secretions . -
pubmed
Experimental study of
WGA binding on the endothelial cell surface in
cerebral ischemia . -
pubmed
In the present study ,
wheat germ
agglutinin (
WGA ) was perfused into capillaries in the area postrema of the normal
Mongolian gerbil , where the blood brain barrier ( BBB ) is known to lack , and into intracerebral blood vessels , the BBB of which had been destroyed by experimentally induced
brain ischemia . -
pubmed
The gerbil , in which
cerebral ischemia had been induced , also showed partial defect of the reaction with
WGA on the luminal side of the endothelial cells . -
pubmed
Four subtypes of
muscarinic acetylcholine receptor (
mAChR ) were stably expressed in neuroblastoma -
glioma hybrid cells (
NG108 - 15 ) . -
pubmed
Antibody prevalence increased with age for all three staff groups , as did the number of individuals exhibiting a marker pattern (
HBcAb greater than
HBsAb ) suggestive of persisting
infection . -
pubmed
Steroid receptors and progestinic therapy in
ovarian endometrioid carcinoma . -
pubmed
Their search for
ER and
PgR receptors in the
tumour tissue showed a particularly high incidence of positive cases ( 81.3 % and 72.1 % respectively ) . -
pubmed
Furthermore , the adjuvant , high - dose
MAP therapy ( Farlutal ) obtained a high incidence of positive responses with neoplastic regression in 53.5 % of the
patients , all of whom were
PgR - and/or
ER - positive cases . -
pubmed
From this standpoint too , the Authors compare ovarian endometrioid
carcinoma to
endometrial carcinoma and believe that the determination of
estrogen and progesterone receptors in the
neoplastic tissue can apply to the former too as a cryterion to select
patients eligible for progestinic therapy . -
pubmed
Among the behavioral variables ,
HDL change was positively associated with change in
alcohol use in both sexes and with change in postmenopausal
estrogen use in women and was inversely associated with change in
obesity index in men . -
pubmed
LDL change correlated positively with change in
obesity index in both sexes . -
pubmed
Sulfonylureas are the chief therapy for
patients with
NIDDM ; for a limited time , these agents stimulate increased
insulin secretion . -
pubmed
With chronic administration ,
sulfonylureas improve the
diabetic patient 's
insulin activity by increasing cellular
insulin receptors and reducing
insulin postreceptor defects . -
pubmed
Regulation of proteolytic processing of the
amyloid beta - protein precursor of
Alzheimer ' s disease in
transfected cell lines and in brain slices . -
pubmed
beta A4 is the principal component of
Alzheimer ' s disease brain amyloid . -
pubmed
Influence of lung maturity on bronchoalveolar
fibrin deposition and clearance in
lung injury syndromes . -
pubmed
All the doses of
Amitriptyline produced significant
hyperglycemia at 4 h , which attained a peak at 24 h with 16 mg / kg dose and appears to be due to blockade of the uptake of monominergic transmitters across the axoplasmic membrane , It ( 16 mg / kg ) also produced
glucose intolerance during early hours probably due to interference with
gastrin function . -
pubmed
The involvement of
catecholamines , in
hypertension ,
alcohol and
ACE - inhibition . -
pubmed
The serotonergic
5 - HT2A receptors are involved in stress - induced
anorexia and regulate the
hyperphagia induced by
neuropeptide Y in the nucleus paraventricularis of the hypothalamus . -
pubmed
Synthetic
MHC class I peptide prolongs cardiac survival and attenuates transplant
arteriosclerosis in the Lewis-->Fischer 344 model of chronic allograft rejection . -
pubmed
The addition of
HLA - B7.75 - 84 decreased overall cellularity ( P<0.01 ) without affecting the composition of the infiltrate , but completely prevented transplant
arteriosclerosis , diminished
myocardial injury , and abrogated expression of
IL-2R ,
IL-2 ,
interferon - gamma ,
tumor necrosis factor - alpha , and
transforming growth factor - beta . -
pubmed
CONCLUSIONS : Therapy with synthetic
class I major histocompatibility complex peptide (
HLA - B7.75 - 84 ) attenuates key histologic features of graft
arteriosclerosis , in association with inhibition of multiple
cytokines and
growth factors and modulation of host alloantibody responses in vivo , which is of interest since Allotrap is currently undergoing clinical trials . -
pubmed
Immunohistochemical evaluation of
bcl-2 oncoprotein in
oral dysplasia and
carcinoma . -
pubmed
The proto - oncogene
bcl-2 is associated with
follicular lymphoma involving translocation t(14;18)(q32;q21 ) and is also overexpressed in various
neoplasms . -
pubmed
We report deregulation of
bcl-2 expression during progression from
oral epithelial dysplasia to squamous cell carcinoma . -
pubmed
Immunohistochemical analysis with monoclonal antibodies to
bcl-2 oncoprotein in
formalin - fixed paraffin - embedded tissue sections revealed that severe
epithelial dysplasias had a higher percentage of immunoreactivity than did mild and moderate
dysplasias and
squamous cell carcinomas . -
pubmed
Expression of this oncoprotein was directly proportional to the degree of
epithelial dysplasia , and nondysplastic basal cells contiguous to
neoplastic lesions also expressed
bcl-2 . -
pubmed
These findings , along with down - regulation of
bcl-2 in differentiating
carcinomas , suggest a role for this oncoprotein in relatively early stages of
oral tumor progression . -
pubmed
Osthol and total
coumarins of
Fructus Cnidii were given to the model of
Kidney - Yang Deficiency rats induced by
hydrocortison acetate injection , the changes of serum concentration of
thyroxine T3 , reverse T3 ( rT3 ) , T4 and
thyroid stimulating hormone (
TSH ) were observed . -
pubmed
RT - PCR was performed to investigate the carboxyl terminus of the published sequence of
hMUC3 from
normal colon and small intestine tissues and also from a series of 10
colorectal cancer cell lines . -
pubmed
Nine out of 10
colorectal cancer cell lines were found to express
MUC3 . -
pubmed
METHODS : A total of 11
B - CLL patients were studied with regard to exposure of leukemic lymphocytes with ( n = 8) or without ( n = 3 )
P2z receptors to
ATP ,
benzoylbenzoic - ATP (
BzATP ) ,
2 - methylthio - ATP (
2MeSATP ) ,
adenosine-5 '-[ gamma - thio ] triphosphate (
ATP - gamma S ) , and other
nucleosides for 8 h in vitro . -
pubmed
GM - CSF regulates
bleomycin - induced
pulmonary fibrosis via a
prostaglandin - dependent mechanism . -
pubmed
To characterize the role of
GM - CSF in
pulmonary fibrosis , we have studied
bleomycin - induced
fibrosis in wild - type
mice vs
mice with a targeted deletion of the GM - CSF gene (
GM - CSF-/-
mice ) . -
pubmed
Without
GM - CSF ,
pulmonary fibrosis was worse both histologically and quantitatively . -
pubmed
We do not have yet sufficient data to conclude whether maximal
androgen blockade from the combined use of an
LH - RH agonist and an antiandrogen will prolong the survival in
patients with
metastatic prostate cancer , nor to conclude whether neoadjuvant
androgen ablation therapy improves the disease - free survival of
patients after radical prostatectomy . -
pubmed
Pain associated with injection of
botulinum A exotoxin reconstituted using isotonic
sodium chloride with and without preservative : a double - blind , randomized controlled trial . -
pubmed
Survivin is a member of the
inhibitor of apoptosis protein ( IAP ) family that is overexpressed during G(2)/M phase in most
cancer cells . -
pubmed
IL-7 exacerbates
chronic colitis with expansion of memory IL-7Rhigh
CD4 + mucosal T cells in
mice . -
pubmed
We have previously demonstrated that mucosal
CD4(+ ) T cells expressing high levels of
IL-7 receptor (
IL-7R(high ) ) are pathogenic cells responsible for
chronic colitis . -
pubmed
Here we investigate whether
IL-7 is directly involved in the expansion of
IL-7R(high ) memory
CD4(+ ) mucosal T cells and the exacerbation of
colitis . -
pubmed
We first showed that
CD4(+ ) lamina propria lymphocytes ( LPLs ) from wild - type , T cell receptor - alpha - deficient ( TCR - alpha(-/- ) ) , and recombinase - activating gene ( RAG)-2(-/-)-transferred
mice with or without
colitis showed phenotypes of memory cells , but only
CD4(+ ) LPLs from colitic
mice showed
IL-7R(high ) . -
pubmed
Importantly , in vivo administration of
IL-7 mice accelerated the expansion of
IL-7R(high ) memory
CD4(+ ) LPLs and thereby exacerbated
chronic colitis in
RAG-2 (-/- ) mice transferred with CD4(+ ) LPLs from
colitic TCR - alpha (-/- ) mice . -
pubmed
Conversely , the administration of
anti - IL-7R monoclonal antibody significantly inhibited the development of
TCR - alpha(-/- )
colitis with decreased expansion of
CD4(+ ) LPLs . -
pubmed
Therefore , therapeutic approaches targeting the
IL-7R pathway may be feasible in the treatment of
human inflammatory bowel disease . -
pubmed
Outer membrane protein with a 53 - kDa molecular weight (
Ag53 ) isolated from
Porphyromonas gingivalis evokes strong humoral immune responses in many
periodontitis patients . -
pubmed
To examine the effects of
cytokines produced by
Ag53 - specific Th cells on the
IgG production against
Ag53 , we established
Ag53 - specific Th - cell lines from
patients with early onset
periodontitis and from healthy volunteers . -
pubmed
Phosphorylation of the
6 - phosphofructo-2 - kinase / fructose 2,6 - bisphosphatase / PFKFB3 family of glycolytic regulators in
human cancer . -
pubmed
PFKFB3 protein is expressed in high levels in
human tumors in situ . -
pubmed
EXPERIMENTAL DESIGN : cDNA from several
human tumor cell lines and
human colon carcinoma were analyzed by reverse transcription - PCR to identify different splicing variants of
PFKFB3 . -
pubmed
The phosphorylation of
PFKFB3 protein in
human cancer was determined by immunostaining using an anti -
phospho -
PFK-2(
PFKFB3 ) antibody . -
pubmed
Quantitative , real - time PCR analysis confirmed the overexpression of
PFKFB3 mRNA in
colon carcinoma , with the dominant variant being the
PFKFB3 - ACG isoform that contains a phosphorylation site at
Ser461 . -
pubmed
CONCLUSIONS : These findings support a potential role for the phosphorylation of
PFKFB3 protein in the progression of
cancer and angiogenesis . -
pubmed
Diabetic nephropathy is diagnosed either when persistent increase of urinary
albumin excretion rate ( UAER ) above 30 mg/24h in a
patient with
diabetes was discovered ( early or incipient
nephropathy ) or when UAER values are persistently elevated above 300 mg/24h ( overt or clinical
nephropathy ) . -
pubmed
Microalbuminuria is currently regarded as a marker of generalized
endothelial damage , it reflects transvascular
albumin leakage , now recognized as an early event in atherogenesis . -
pubmed
Recently the association of
microalbuminuria with the marker of
chronic inflammation (
C - reactive protein ) and with increased production of
vascular endothelial growth factor (
VEGE ) was described . -
pubmed
Leptin and
renal disease . -
pubmed
This review elucidates the complex uremic state , the historical discovery of
leptin and its physiology , and the potential interactions
leptin has on both the progression of
kidney disease as well as the morbidity and mortality of
end - stage renal disease . -
pubmed
CONCLUSION : Persisting duodenal
hyperacidity is created by an inherited high
PCM and loss of
gastrin control . -
pubmed
CONCLUSION : The ability of phiC31
integrase to facilitate genomic integration in synovial cells and increase transgene expression in the
rabbit synovium suggests that , in combination with more efficient DNA delivery methods , this
integrase system could be beneficial for treatment of
rheumatoid arthritis and other
joint disorders . -
pubmed
Maternal serum free
beta - hCG levels were lower in pregnancies complicated by
pre - eclampsia than in normotensive ones . -
pubmed
Multivariable analysis found
PAPP - A to be an independent predictor of absolute birth weight ,
SGA , and LGA . -
pubmed
Free
beta - hCG was found to be an independent predictor of
gestational hypertension and pre -
eclampsia . -
pubmed
CONCLUSION(S ): Maternal serum
PAPP - A levels in the late first trimester of pregnancy are associated with subsequent fetal growth ( including both physiologic variation and abnormal growth ) , and decreased free
beta - hCG is more predictive of
hypertensive disorders of pregnancy . -
pubmed
In the breeds analysed [ Charolais , Czech Spotted ( Czech Simmental ) , Belgian Blue , Limousine , Blonde d'Aquitaine , Aberdeen Angus , and Beef Simmental sires reared in the Czech Republic ] , the recessive allele was not found in the
PYGM (
phosphorylase glycogen , muscle ) responsible for the
glycogen storage disease type V. -
pubmed
In the same panel , the recessive allele in exon 7 , exon 9 and exon 13 of the
GAA (
glucosidase alpha , acid ) , causing the
glycogen storage disease type II was not found . -
pubmed
We determined if exposure to the duodenal helminth
Heligmosomoides polygyrus establishes
cytokine pathways in the distal intestine that may protect from intestinal
inflammation . -
pubmed
polygyrus were resistant to
trinitrobenzenesulfonic acid (
TNBS)-induced
colitis , a Th1
cytokine - dependent inflammation . -
pubmed
IL-10 blockade in vivo worsened TNBS
colitis in
H. - pubmed
Elevated expression and polymorphisms of
SOCS3 influence
patient response to antiviral therapy in
chronic hepatitis C. -
pubmed
Furthermore , an association study was performed , testing three single
nucleotide polymorphisms ( SNPs ) of
suppressor of cytokine signalling 3 (
SOCS3 ) in 162
NR and 184 SVR subjects (
SOCS3 -8464 A / C ( rs12952093 ) , -4874 A / G ( rs4969170 ) and 1383 A / G , ( rs4969168 ) ) . -
pubmed
Use of
aromatase inhibitors rather than
tamoxifen for
breast cancer will likely lead to more
osteoporosis . -
pubmed
Aminoglycosides were systemically delivered to two
rodent models of
retinal degeneration : a transgenic
rat model of
dominant disease caused by a PTC in
rhodopsin ( S334ter ) ; and a
mouse model of
recessive disease ( rd12 ) caused by a PTC in the
retinoid isomerase
Rpe65 . -
pubmed
Here , we report that
H2O2 - induced
cellular toxicity acts through
Prdx6 hyperoxidation . -
pubmed
Expression and function of
phospholipase C in
breast carcinoma . -
pubmed
In
liver fibrosis , dendritic cells govern
hepatic inflammation in
mice via
TNF - alpha . -
pubmed
Epigenetically regulated clonal heritability of
CTA expression profiles in
human melanoma . -
pubmed
The intratumoral heterogeneity of
cancer testis antigens (
CTA ) expression , which is driven by promoter methylation status , may hamper the effectiveness of CTA - directed vaccination of
melanoma patients . -
pubmed
Most inhaled food
allergy is
IgE mediated , and skin prick tests or specific
IgE tests are useful tools to support the diagnosis , but objective evidence of
asthma by monitoring of peak expiratory flows at and off work or specific inhalation challenges offers a better diagnostic value . -
pubmed
These data suggest that
AP - aldolase is stabilized by binding to the native structure , and they provide a foundation for developing stabilizing compounds for potential therapeutics for
HFI . -
pubmed
Human ZNF312b oncogene is regulated by
Sp1 binding to its promoter region through DNA demethylation and histone acetylation in
gastric cancer . -
pubmed
In a previous study ,
human ZNF312b was identified as a cell proliferation - associated oncogene via the
K - ras /
extracellular signal - regulated kinase cascade in
gastric cancer . -
pubmed
Here , we show that DNA methylation and histone acetylation of the
ZNF312b promoter function as a switch for
ZNF312b transcriptional activation in
gastric cancer . -
pubmed
The transcription level of
ZNF312b was increased by treatment with a demethylating agent ,
5 - aza-2 '- deoxycytidine and the
histone deacetylase inhibitor
sodium butyrate , in several
human cancer cell lines including
gastric cancer . -
pubmed
Consistent with these results , epigenetic analysis , such as pyrosequencing ,
bisulfate sequencing and
methyl - specific polymerase chain reaction ( MSP ) , showed that the expression level of
ZNF312b is highly dependent on the degree of DNA methylation in
gastric cancer cell lines . -
pubmed
Moreover , a knockdown of
Sp1 resulted in a decrease in
ERK - mediated proliferation via downregulation of the
ZNF312b gene in
gastric cancer cells . -
pubmed
Taken together , these results suggest that the aberrant expression of
ZNF312b promotes gastric tumorigenesis through epigenetic modification of its promoter region and provides a molecular mechanism for
ZNF312b expression to contribute to the progression of
gastric cancer . -
pubmed
B - type natriuretic peptide levels predict extent and severity of
coronary disease in
non - ST elevation coronary syndromes and normal left ventricular systolic function . -
pubmed
BACKGROUND :
B - type natriuretic peptide (
BNP ) has been used recently as a biological marker in
patients with
coronary artery disease (
CAD ) with ST - elevation , as well as without ST - elevation . -
pubmed
BNP is able to predict
systolic dysfunction , adding new prognostic information to existing traditional markers . -
pubmed
However is not known if there is a relation between the quantity of
BNP levels and the severity of
coronary artery disease . -
pubmed
METHODS : This study compared
B - type natriuretic peptide (
BNP ) levels in
patients with
stable angina (
SA ) and
acute coronary syndromes (
ACS ) without ST - elevation in relation to angiographic lesions using TIMI and Gensini Scores . -
pubmed
RESULTS :
BNP values were progressively increased in relation to the severity of diagnosis :
SA ( 52.6 + -49.4 pg / mL ) UA ( 243.3 + -212 pg / mL ) NSTE - ACS ( 421.7 + -334 pg / mL ) ( p<0.0001 and p<0.007 respectively ) . -
pubmed
The analysis of
BNP levels in relation to the number of involved vessels demonstrated significantly increased levels in
patients with
multivessel disease compared to
patients with 1 or 2 vessel disease ( 1 - 86.2 + -46.3 pg / mL ; 2 - 127 + -297 pg / mL ; 3 - 295 + -318 pg / mL ; 4 - 297 + -347 pg / mL p<0.001 and p<0.003 ) . -
pubmed
Evaluation of
BNP using Gensini Score showed a strong relation between
BNP and
coronary disease extension ( r=0.38 p<0.0001).This trend was maintained in all
CAD groups ( SA = r 0.54 ; UA r=0.36 NSTE - ACS r=0.28 ) . -
pubmed
CONCLUSIONS : Circulating
BNP levels appear elevated in
ACS with diffuse coronary involvement , even in the absence of
systolic dysfunction . -
pubmed
BNP is also associated with
multi - vessel disease and the extension of
coronary disease . -
pubmed
Labeled cardiac stem cells were identified in the
infarct zone and
infarct marginal zone and expressed
Connexin-43 ,
von Willebrand factor ,
alpha - smooth muscle actin , and
alpha - sarcomeric actin . -
pubmed
Recently , evidence has also emerged that
renin -
angiotensin system (
RAS ) inhibitors may electively prevent or delay progression of
retinopathy , possibly because of specific protective effect against the structural and functional retinal changes sustained by local
RAS activation . -
pubmed
Thus , metabolic and blood pressure control by
RAS inhibition is to prevent or limit the onset of
retinopathy and its progression towards visual - threatening stages . -
pubmed
Topic treatment with anti -
vascular endothelial growth factor (
VEGF ) agents is emerging as a treatment option for
retinopathy in advanced stages to limit the need for laser photocoagulation . -
pubmed
Blocking of
selectins is therefore considered a promising therapeutic approach to treat acute and
chronic inflammatory diseases which are caused by excessive extravasation of leukocytes . -
pubmed
Moreover , significant correlation was found between multiple
viral infection ( JCV , and/or
SV40 , and/or
MMTV - like in the same
tumor ) and " triple negative " phenotype ( P = 0.001 ) and also with
p53 accumulation ( P = 0.028 ) . -
pubmed
Glomerular expression of
hydrogen peroxide - inducible clone-5 in
human and
rat progressive mesangial proliferative
glomerulonephritis . -
pubmed
BACKGROUND / AIMS :
Hydrogen peroxide - inducible clone-5 (
Hic-5 ) is a
transforming growth factor - beta ( 1 ) (
TGF - beta ( 1 ))- and hydrogen peroxide ( H ( 2 ) O ( 2 ))- inducible focal adhesion protein that may be necessary for maintaining the myofibroblastic phenotype in pathological
scar formation . -
pubmed
To investigate the involvement of
Hic-5 in the pathogenesis of
glomerulonephritis (
GN ) , we examined the glomerular expression of
Hic-5 in
human and
rat GN as well as the regulation of
Hic-5 by
TGF - beta ( 1 ) in vitro . -
pubmed
Hic-5 expression was significantly correlated not only with the levels of
alpha - smooth muscle actin (
alpha - SMA ) and
TGF - beta ( 1 ) , the accumulation of extracellular matrix , and the number of glomerular cells , but also with the urinary protein level in
patients with
GN . -
pubmed
Glomerular
Hic-5 expression increased in parallel with
alpha - SMA expression in a
rat model of
mesangial proliferative GN . -
pubmed
CONCLUSION : Our findings suggest that
Hic-5 is involved in changes in the MC phenotype to produce abnormal extracellular matrix remodeling in
GN . -
pubmed
Many members of the
NOD - like receptor ( NLR ) family play important roles in pathogen recognition and
inflammation . -
pubmed
The HAP - induced DNA damage and
cytotoxicity observed in
ITPA knockdown cells are rescued by an overexpression of the
yeast ITPase encoded by the
HAM1 gene . -
pubmed
T - cell receptor signaling and the pathogenesis of
autoimmune arthritis : insights from
mouse and
man . -
pubmed
In this review we consider recent evidence that has provided insight into how altered
TCR signaling thresholds could contribute to
human autoimmune arthritis , including
rheumatoid arthritis (
RA ) , and the
spondyloarthropathies (
SpA ) . -
pubmed
From genetic association studies to the biology of
interleukin-28B in
hepatitis C virus infection and beyond . -
pubmed
In this study , we used quantitative real - time PCR and a luciferase reporter assay to determine whether
PPV infection induces
type I interferon (
IFN - alpha and
IFN - beta ) and whether
PPV infection blocks dsRNA - induced IFN - beta promoter activation in cell cultures . -
pubmed
Discovery of somatic
STAT5b mutations in
large granular lymphocytic leukemia . -
pubmed
Recently , somatic mutations in the
signal transducer and activator of transcription 3 (
STAT3 ) gene were discovered in 28 % to 40 % of
LGL leukemia patients . -
pubmed
By exome and transcriptome sequencing of 2
STAT3 mutation - negative
LGL leukemia patients , we identified a recurrent , somatic missense mutation ( Y665F ) in the
Src - like homology 2 domain of the STAT5b gene . -
pubmed
Targeted amplicon sequencing of 211
LGL leukemia patients revealed 2 additional patients with
STAT5b mutations ( N642H ) , resulting in a total frequency of 2 % ( 4 of 211 ) of
STAT5b mutations across all patients . -
pubmed
This is the first time somatic
STAT5 mutations are discovered in human
cancer and further emphasizes the role of
STAT family genes in the pathogenesis of
LGL leukemia . -
pubmed
Mutations in several genes have been implicated as playing a pathogenic role in the
corneal endothelial dystrophies :
VSX1 mutations in
PPCD1 ;
COL8A2 mutations in
PPCD2 and
FECD ;
ZEB1 mutations in
PPCD3 and
FECD ; and
SLC4A11 mutations in
CHED2 and
FECD . -
pubmed
However , linkage , association and familial segregation analyses support a role of only one gene in each
corneal endothelial dystrophy :
ZEB1 in
PPCD3 ,
SLC4A11 in
CHED2 and
COL8A2 in
FECD ( early onset ) . -
pubmed
The classical drug targets for the treatment of
schizophrenia are
dopamine D2 receptors . -
pubmed
Proteinuria and
VEGF - targeted therapies : : an underestimated
toxicity ? -
pubmed
Oncologists and nephrologists usually manage
proteinuria related to anti -
vascular endothelial growth factor ( anti -
VEGF ) treatment only when it is in the
nephrotic range or associated with
renal insufficiency . -
pubmed
We found that
proteinuria induced by anti -
VEGF therapy , even if weak and without associated
renal insufficiency , may reflect a serious
histological renal disease . -
pubmed
The predisposing role to
human obesity of the
MC3R gene polymorphism is controversial . -
pubmed
Furthermore , the compounds did not show any signs of
cardiotoxicity in
zebrafish ether - a - go - go - related gene (
zERG ) , and hence constitute a major breakthrough among the otherwise
cardiotoxic N - linked aminopiperidine analogues . -
pubmed
Seahorse - derived peptide suppresses invasive migration of
HT1080 fibrosarcoma cells by competing with intracellular
alpha - enolase for
plasminogen binding and inhibiting
uPA - mediated activation of
plasminogen . -
pubmed
alpha - Enolase - bound
plasminogen promotes
tumor cell invasion and
cancer metastasis by activating
plasmin and consequently degrading the extracellular matrix degradation . -
pubmed
Therefore ,
alpha - enolase and
plasminogen are novel targets for
cancer therapy . -
pubmed
In this study , we report that this peptide competes with cellular
alpha - enolase for
plasminogen binding and suppresses
urokinase plasminogen activator (
uPA)-mediated activation of
plasminogen , which results in decreased invasive migration of
HT1080 fibrosarcoma cells . -
pubmed
Ryk is essential for
Wnt-5a - dependent invasiveness in
human glioma . -
pubmed
Recently , we reported that
Wnt-5a was overexpressed and correlated with cell motility and infiltrative activity through the regulation of
matrix metalloproteinase ( MMP )- 2 in
glioma - derived cells . -
pubmed
Although several receptors for
Wnt-5a were identified , the receptors of
Wnt-5a that mediate cellular responses of
glioma were not clearly identified . -
pubmed
Knockdown of
receptor - like tyrosine kinase (
Ryk ) but not that of
Ror2 suppressed the activity of
MMP-2 and
Wnt-5a - dependent invasive activity in
glioma cells . -
pubmed
These results suggest that
Ryk is important for the
Wnt-5a - dependent induction of
MMP-2 and invasive activity in
glioma - derived cells and that
Ryk might have a novel patho - physiological function in adult
cancer invasion . -
pubmed
Furthermore , not only the expression of
Wnt-5a but also that of
Frizzled (
Fz)-2 and
Ryk was correlated with the WHO histological grade in 38
human glioma tissues . -
pubmed
Taking these findings together ,
Fz-2 and
Ryk could be therapeutic or pharmacological target molecules for the control of
Wnt-5a - dependent invasion of
human glioma in the near future . -
pubmed
Omarigliptin (
MK-3102 ): a novel long - acting
DPP-4 inhibitor for once - weekly treatment of
type 2 diabetes . -
pubmed
Immunohistochemically , the
tumours were positive for
pancytokeratin but negative for
synaptophysin and
chromogranin A. -
pubmed
Previous SS studies have demonstrated an increase in
VEGF - A /
VEGFR-2 system expression in minor salivary gland ( MSG ) biopsies from
patients with
SS , but differences in the new blood vessel formation between the different grades of disease severity have not been reported . -
pubmed
Actin dynamics are critical for muscle development and function , and mutations leading to deregulation of
actin dynamics cause various forms of heritable
muscle diseases . -
pubmed
In adult
mice ,
Wdr1 deletion resulted in similar but much milder phenotypes of
heart hypertrophy ,
F - actin accumulations within myofibrils , and lethality . -
pubmed
Thymidine kinase 1 is a better prognostic marker than
Ki-67 for pT1
adenocarcinoma of the lung . -
pubmed
OBJECTIVES : The sensitivity and reliability of the biomarkers
thymidine kinase 1 (
TK1 ) and
Ki-67 were studied in relation to clinical features and prognosis of survival for pathological - T1 ( pT1 ) lung
adenocarcinoma patients . -
pubmed
METHODS :
TK1 and
Ki-67 expression was determined in 80
patients with pT1
adenocarcinoma of the lung and in 20 specimens from
normal lung tissues , using immunohistochemistry . -
pubmed
RESULTS :
TK1 was found in most lung
tumor cells both in the cytoplasm and the nuclei . -
pubmed
There was a significant correlation between the LI of total
TK1 and lymph node metastasis , degree of
tumor invasion and pathologic stages , which was not found for
Ki-67 . -
pubmed
In addition , the overall 5 - year survival of
patients was statistically significant different between
low and high levels of TK1 expression , but not in cases of
Ki-67 . -
pubmed
A multivariate analysis revealed that expression of
TK1 , lymph node involvement and TNM pathology staging could serve as independent prognostic factors for the
disease progression of
pT1 lung adenocarcinoma patients . -
pubmed
CONCLUSIONS : Compared with
Ki-67 ,
TK1 is a more reliable proliferation index in pT1
adenocarcinoma of lung , which can evaluate the invasion and the prognosis of
tumor . -
pubmed
Bothropoidin induced
haemorrhage [ minimum
haemorrhagic dose ( MHD ) = 0.75 microg ] , inhibited
platelet aggregation induced by
collagen and
ADP , and interfered with viability and cell adhesion when incubated with endothelial cells in a dose and time - dependent manner . -
pubmed
pauloensis envenomation and might be used as a tool for studying the effects of
SVMPs on
haemostatic disorders and
tumour metastasis . -
pubmed
GWAS confirm the importance of the
alcohol dehydrogenase gene cluster on chromosome 4 in the genetic risk for
alcohol dependence with multiple variants that exert a small , but cumulative influence . -
pubmed
Downregulated
Ku70 and
ATM associated to poor prognosis in
colorectal cancer among Chinese patients . -
pubmed
To address the relationship between altered expression of DSB repair of proteins
Ku70 and
ataxia - telangiectasia mutated (
ATM ) in
colorectal cancer (
CRC ) , we examined the expression levels and patterns of
Ku70 and
ATM in
CRC samples . -
pubmed
METHODS : Expression and coexpression of
Ku70 and
ATM were investigated by using real - time quantitative polymerase chain reaction assays and confirmed further with fluorescent immunohistochemistry in
CRC and
pericancerous samples from 112 Chinese patients . -
pubmed
RESULTS : Downexpression patterns for both
Ku70 and
ATM were found in the
CRC samples and were significantly associated with advanced
tumor node metastasis stage and decreased 5 - year overall survival rate . -
pubmed
CONCLUSION : Downregulated
Ku70 and
ATM were associated with poor
disease - free survival . -
pubmed
Loss of
Ku70 and
ATM expression might act as a biomarker to predict poor prognosis in
patients with
CRC . -
pubmed
Expression of high level
methicillin resistance in a laboratory
MSSA strain resulted in ( i ) repression of PIA - mediated biofilm production , ( ii ) down - regulation of the accessory gene regulator (
Agr ) system , and ( iii ) attenuation of virulence in murine
sepsis and device
infection models . -
pubmed
Molecular characterization and
hypoxia - induced upregulation of
neuronal nitric oxide synthase in
Atlantic croaker : Reversal by antioxidant and
estrogen treatments . -
pubmed
However , the influence of antioxidants and
steroids on
nNOS upregulation by
hypoxia is largely unknown . -
pubmed
In this study , we characterized
nNOS cDNA and examined the effects of
hypoxia and antioxidant and
steroid treatments on
nNOS expression in
Atlantic croaker hypothalamus . -
pubmed
In contrast , treatments with
Nomega - nitro - L - arginine methyl ester , a competitive
NOS - inhibitor , or
vitamin E , an antioxidant , prevented the upregulation of
O2 ( - ) production and
nNOS expression in
hypoxia - exposed ( DO : 1.7 mg / L for 4 weeks ) fish . -
pubmed
Moreover , treatment with
1,4,6 - androstatrien-3,17 - dione , an
aromatase inhibitor , increased hypothalamic
O2 ( - ) production and
nNOS expression in normoxic control
fish ; whereas
estradiol-17beta treatment significantly reduced
O2 ( - ) production and
nNOS expression in
hypoxia - exposed
fish . -
pubmed
Taken together , the results suggest that upregulation of
nNOS and ROS in the croaker hypothalamus in response to
hypoxia is influenced by antioxidant and overall
estrogen status . -
pubmed
Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized
13C - Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in
Tumors . -
pubmed
We assessed the functional activity of
CAIX in two colorectal
tumor models , expressing different levels of the enzyme , by measuring the rate of exchange of hyperpolarized
( 13 ) C label between
bicarbonate (
H ( 13 ) CO3 (- ) ) and
carbon dioxide (
( 13 ) CO2 ) , following injection of hyperpolarized
H ( 13 ) CO3 (- ) , using
( 13 ) C - magnetic resonance spectroscopy (
( 13 ) C - MRS ) magnetization transfer measurements . -
pubmed
( 31 ) P - MRS measurements of the chemical shift of the pH probe ,
3 - aminopropylphosphonate , and
( 13 ) C - MRS measurements of the
H ( 13 ) CO3 (-)/( 13 ) CO2 peak intensity ratio showed that
CAIX overexpression lowered extracellular pH in these
tumors . -
pubmed
Paradoxically ,
tumors overexpressing
CAIX showed lower enzyme activity using magnetization transfer measurements , which can be explained by the more acidic extracellular pH in these
tumors and the decreased activity of the enzyme at low pH. -
pubmed
These results suggest that
CAIX expression is increased in
hypoxia to compensate for the decrease in its activity produced by a low extracellular pH and supports the hypothesis that a major function of
CAIX is to lower the extracellular pH. -
pubmed
Immortalized
human esophageal myofibroblasts also express the putative acid receptor
TRPV1 and
TLR4 and retain the functional capacity to respond to stimuli encountered in
GERD with secretion of
IL-6 . -
pubmed
Therefore , we examined the impact of deletion of the
alpha11 integrin in wild - type
mice and in
mice treated with
streptozotocin (
STZ ) to elucidate the role of the
alpha11 integrin in normal cardiac homeostasis and in the pathogenesis of
diabetes - related
fibrosis . -
pubmed
As anticipated ,
cardiac fibrosis was reduced in
alpha11 integrin knockout
mice ( alpha11(-/- ) ; C57BL/6 background ) treated with
STZ compared with
STZ - treated wild - type
mice ( P & lt ; 0.05 ) . -
pubmed
Overall , deletion of the
alpha11 integrin attenuates
cardiac fibrosis in the
mammalian mouse heart and reduces ECM formation as a result of
diabetes . -
pubmed
In addition , PM2.5 increased the production of
granulocyte - macrophage colony - stimulating factor ,
tumor necrosis factor - alpha ,
interleukin-13 and
eotaxin (
C - C motif chemokine ligand 11 ) , each of which initiates and/or augments local
inflammation . -
pubmed
In recent research , it has been shown that there have been variants of rs12026 within the
paraoxonase 2 (
PON2 ) gene , which have been associated with
cardiovascular disease ,
cerebrovascular disease ,
diabetes and other diseases . -
pubmed
Erratum to : High
Jagged1 expression is associated with poor outcome in
primary glioblastoma . -
pubmed
Detection of
Chlamydia was associated with expression of
cyclooxygenase-2 and
interleukin-8 by superficial epithelial cells . -
pubmed
CONCLUSION : Neutrophils , plasma cells and
IL-8 have been linked with
Chlamydia genital infection of unknown duration in
human patients . -
pubmed
Hyaluronate synthase-2 overexpression alters
estrogen dependence and induces
histone deacetylase inhibitor - like effects on ER - driven genes in
MCF7 breast tumor cells . -
pubmed
In
breast carcinoma cells , high levels of hyaluronan ( HA ) and its
CD44 receptor are frequently associated with alteration in
estrogen signaling . -
pubmed
In conclusion , increase in
HA /
CD44 interactions may contribute , through an
HDAC inhibitor - like and
ER - independent mechanism , to the silencing of
estrogen - driven genes in
breast carcinoma . -
pubmed
Polymeric
immunoglobulin receptors(
pIgR ) are key participants in the formation and secretion of secretory
IgA(
S - IgA ) , which is critical for the prevention of
microbial infection and colonization in the respiratory system . -
pubmed
Although increased respiratory colonization and
infections are common in
HIV /
AIDS , little is known about the expression of
pIgR in the airway mucosa of these patients . -
pubmed
These results indicated abnormal
pIgR expression in SHIV / SIV , and by extension
HIV infections , which might partially result from
IL-17A alterations and might contribute to the increased microbial colonization and
infection related to pulmonary complications in HIV /
AIDS . -
pubmed
Role of
IL-21 in
HTLV-1 infections with emphasis on
HTLV-1 - associated myelopathy /
tropical spastic paraparesis (
HAM /
TSP ) . -
pubmed
Interleukin-21 (
IL-21 ) enhances the survival and cytotoxic properties of cytotoxic T cells ( CTLs ) and exhibits essential roles in controlling chronic
viral infections . -
pubmed
In this study , the expression of host
IL-21 and
HTLV - I Tax and proviral load ( PVL ) was evaluated to understand the role and mechanism of
IL-21 in
HTLV-1 infections and the subsequent development of
HAM /
TSP . -
pubmed
A cross - sectional study was carried out on 20
HAM /
TSP patients , 20 asymptomatic
HTLV-1 carriers (
ACs ) and 20 healthy controls ( HCs ) to evaluate the expression of
IL-21 and
Tax and
PVL in non - activated and
phorbol myristate acetate (
PMA)-
ionomycin - activated peripheral blood mononuclear cells ( PBMCs ) . -
pubmed
The mean mRNA expression of
IL-21 in the non - activated and activated PBMCs was higher ( by 5 - 13 times ) in the
HAM /
TSP patients than in
ACs and
HCs ( p & lt ; 0.05 ) ; however , there was no significant difference between
ACs and
HCs . -
pubmed
In contrast to the IL-21 mRNA expression , the serum level of the
IL-21 protein was significantly lower in the
HAM /
TSP patients than in
ACs and
HCs ( p & lt ; 0.05 ) . -
pubmed
Furthermore , higher expression of
Tax and
PVL was observed in the
HAM /
TSP subjects than
ACs ( p & lt ; 0.05 ) . -
pubmed
In a post - germinal center B - cell in vitro model , permanent
latent membrane protein 1 (
LMP1 ) expression , as observed in
Epstein - Barr virus ( EBV )- associated cHL , results in multinuclearity and complex chromosomal aberrations through downregulation of key element of the shelterin complex , the
telomere repeat binding factor 2 (
TRF2 ) . -
pubmed
Thus , we hypothesized that the three - dimensional ( 3D ) telomere -
TRF2 interaction was progressively disturbed during transition from H to
RS cells . -
pubmed
To this end , we developed and applied for the first time a combined quantitative 3D
TRF2 - telomere immune fluorescent in situ hybridization ( 3D
TRF2 / Telo - Q - FISH ) technique to monolayers of primary
H and RS cells , and adjacent benign internal control lymphocytes of lymph node biopsy suspensions from diagnostic lymph node biopsies of 14
patients with
cHL . -
pubmed
This pattern is typical of , but is not restricted to ,
LMP1+EBV - associated
cHL . -
pubmed
In the disruption pattern B group , so - called ' ghost ' end - stage
RS cells , void of both
TRF2 and telomere signals , were identified , whether or not associated with
EBV . -
pubmed
Cytokine expression levels in
ALS : A potential link between
inflammation and
BMAA - triggered protein misfolding . -
pubmed
Recently , it has been shown that proinflammatory
cytokines play a complex and important role in the pathogenesis of many
neurological disorders , including
amyotrophic lateral sclerosis (
ALS ) . -
pubmed
To help facilitate future discoveries and more effective treatment strategies , we highlight the role that both innate and adaptive immune systems play in
ALS and summarize the main observations that relate to
cytokine expression levels in this disease . -
pubmed
Inhibition of
STAT3 signaling pathway by
ursolic acid suppresses growth of
hepatocellular carcinoma . -
pubmed
The
signal transducer and activator of transcription 3 (
STAT3 ) has been found to be constitutively active in
liver cancer . -
pubmed
There is no
STAT3 inhibitors approved to be used clinically for the treatment or prevention of
liver cancer . -
pubmed
However , whether UA could inhibit
STAT3 phosphorylation in
hepatocellular carcinoma has not been reported . -
pubmed
The inhibitory effects of UA on
STAT3 phosphorylation , along with cell viability , migration , colony formation in vitro , as well as
tumor growth in vivo were examined in
human liver cancer cell lines . -
pubmed
Our data showed that UA inhibited the
P - STAT3 induced by
interleukin-6 (
IL-6 ) in
Hep3B liver cancer cells which express very low basal level of
P - STAT3 . -
pubmed
The constitutive
STAT3 phosphorylation was also inhibited by UA in
HEPG2 , 7721 and
Huh7 human liver cancer cell lines . -
pubmed
Furthermore , UA suppressed
STAT3 phosphorylation and
HEPG2 tumor growth by oral daily treatment in vivo . -
pubmed
UA , which exists widely in
fruits and herbs , could inhibit
STAT3 activation and the growth of
human liver cancer cells in vitro and in vivo . -
pubmed
A polymorphism in
ABCC4 is related to efficacy of
5 - FU /
capecitabine - based chemotherapy in
colorectal cancer patients . -
pubmed
Statistical analysis showed that a polymorphism rs3742106 in the 3'-UTR of
ATP - binding cassette subfamily C member 4 (
ABCC4 ) gene was significantly associated with the efficacy of
5 - FU /
capecitabine - based chemotherapy in
CRC . -
pubmed
Methods : Adult chemotherapy - naive
patients with confirmed
prostate adenocarcinoma , Eastern Cooperative Oncology Group ( ECOG ) performance status ( PS ) grade 0 - 1 , ongoing
androgen deprivation ( serum
testosterone & lt;50 ng / dL ) with
prostate specific antigen (
PSA ) or radiographic progression were randomized to receive
abiraterone acetate ( 1000 mg , QD ) +
prednisone ( 5 mg , BID ) or placebo +
prednisone ( 5 mg , BID ) , until disease progression , unacceptable
toxicity or consent withdrawal . -
pubmed
ST2 blockade during skin sensitization inhibited the development of
anaphylaxis , antigen - specific
IgE , and inflammatory mediators . -
pubmed
BACKGROUND :
Imatinib is
tyrosine kinase inhibitor ( TKI ) and as a targeted anti - cancer agent has significantly changed
chronic myeloid leukemia (
CML ) prognosis and
patient survival . -
pubmed
RESULTS : Our study proved that
CML patients , who had achieved
MMR by original
imatinib therapy , retained
MMR during 24 months of generic
imatinib therapy . -
pubmed
CONCLUSION : Our study proved that
CML patients , who had achieved
MMR by original
imatinib therapy , retained
MMR during 24 months of generic
imatinib therapy . -
pubmed
Baseline DNAmeth did not differ between
GR and WR for any tested genes , even when the analysis was restricted to subjects with no
diabetes . -
pubmed
The clinical relevance of serum
vascular endothelial growth factor (
VEGF ) in correlation to circulating
tumor cells and other serum biomarkers in
patients with metastatic
breast cancer . -
pubmed
PURPOSE :
VEGF is one of the most important angiogenesis - stimulating
cytokines and has been previously shown to be overexpressed in several
solid cancers . -
pubmed
The aim of the present study was to assess the clinical relevance of serum
VEGF (
sVEGF ) in a large cohort of metastatic
breast cancer patients and to explore the relationship between
sVEGF and other blood - based biomarkers . -
pubmed
Circulating
tumor cells ( CTCs ) were detected using CellSearch and other biomarkers (
EGFR ,
HER2 ,
RAS p21 ,
TIMP1 ,
CAIX ) by ELISA . -
pubmed
Patients with
sVEGF levels & gt;= 367 pg / ml and & gt;= 5
CTCs had the shortest OS , while those with
sVEGF &
lt ; 367 pg / ml and
non - elevated CTCs had the longest OS . -
pubmed
CTCs , grading , line of therapy and
RAS p21 were independent predictors of OS . -
pubmed
CONCLUSIONS : Metastatic
breast cancer patients with elevated levels of
sVEGF have significantly worse clinical outcome . -
pubmed
This finding supports the biological role of
VEGF in
breast cancer . -
pubmed
Joint associations of serum
uric acid and
ALT with
NAFLD in elderly men and women : a Chinese cross - sectional study . -
pubmed
BACKGROUND : Epidemiological evidence suggests sex difference in serum
uric acid ( SUA ) and
alanine aminotransferase (
ALT ) might be a potential explanation for the gender difference in prevalence of
non - alcoholic fatty liver disease (
NAFLD ) . -
pubmed
METHODS : We conducted a cross - sectional study to assess the joint associations between SUA and serum
ALT with
NAFLD among elderly Chinese men and women . -
pubmed
In addition , the ORs of
NAFLD among participants with high
SUA levels and high serum
ALT was 10.75 ( 95 % CI 3.56 - 32.46 ) for men and 7.96 ( 95 % CI 2.83 - 22.39 ) for women , compared with those with low
SUA levels and low serum
ALT . -
pubmed
A significant joint association of SUA and serum
ALT with
NAFLD prevalence was observed in all participants , which was slightly stronger in men than in women . -
pubmed
Immunoexpression of
Transforming Growth Factor Beta 3 (
TGFbeta3 ) and Its Receptor Type III (
TGFbetaRIII ) in
Basal Cell Carcinomas . -
pubmed
In this study we analyzed the immunoexpression of
transforming growth factor beta 3 (
TGFbeta3 ) and its receptor type III (
TGFbetaRIII ) for 53 cases of
BCC in relation to the main histopathological prognostic parameters . -
pubmed
The results indicated statistically significant differences of
TGFbeta3 and
TGFbetaRIII expression related to histological type and lesion stage , the both proteins being higher expressed in adenoid and morpheaform advanced stage
tumors . -
pubmed
In this study ,
TGFbeta3 and
TGFbetaRIII immunoexpression analysis indicated their utility for identifying aggressive
BCCs with potential for
tumor progression . -
pubmed
Based on the initial analysis of
kidney renal clear cell carcinoma dataset from The Cancer Genome Atlas , genes
MT1E ,
MT1F ,
MT1 G and
MT1 M were selected for qualitative methylation analysis in 30
tumors ( including 10 multifocal cases ) , 10 pericancerous , and 30
non - cancerous renal tissues ( NRT ) . -
pubmed
Methylation of
MT1E and
MT1 M was
tumor - specific ( P=0.0056 and P=0.0486 , respectively ) and showed moderate interfocal variation in paired
tumor foci . -
pubmed
Furthermore , aberrant
MT1E methylation was more frequent in
tumors having
necrotic zones ( P=0.0449 ) or characterized with higher differentiation grade ( P=0.0144 ) , while
MT1 M was more commonly methylated in
tumors with higher Fuhrman grade ( P=0.0272 ) . -
pubmed
Gene expression analysis ( 51
RCC and 9 NRT ) revealed
MT1 G downregulation in
tumors ( P<0.0001 ) , while lower
MT1E expression levels were associated with the promoter methylation ( P=0.0077 ) . -
pubmed
In clear cell
RCC ,
MT1E ,
MT1 G and
MT1 M expression was higher than that noted in other histological
tumor subtypes ( all P<0.0500 ) . -
pubmed
In conclusion , the present study revealed the potential role of
MT1E and
MT1 M promoter methylation in
RCC development . -
pubmed
Genetic variants of
calcium sensing receptor gene and risk of
colorectal cancer : A case - control study . -
pubmed
Objectives : To determine the role of two genetic variants , ( rs3804594 ) and ( rs1801725 ) , in
calcium sensing receptor (
CASR ) gene with
colorectal cancer (
CRC ) risk in patients visited King Abdulaziz University hospital ( KAUH ) in Jeddah , Saudi Arabia . -
pubmed
Results : Data obtained from chi2 test showed that intron 4 variant in
CASR gene was distributed 100 % normally in the 224 participants , however , exon 7 variant showed 100 % homozygous distribution in the controls ; whereas , in
CRC patients it was distributed equally into 50 % heterozygous and 50 % homozygous with no detection for wild type . -
pubmed
Conclusion : Intron 4 variant ( rs3804594 ) in
CASR gene is not correlated to
CRC risk . -
pubmed
However , more investigations are needed to elucidate the role of
CASR gene exon 7 ( rs1801725 ) variant in
CRC development as the current results are not definitive . -
pubmed
The correlation between low - methylation subgroup and
IPF was further validated by quantitative methylation analysis of marker genes commonly hypermethylated in
SCC (
HOXA2 ,
HOXA9 and
PCDHGB6 ) , and markers specifically hypermethylated in high - methylation subgroup (
DLEC1 ,
CFTR ,
MT1 M ,
CRIP3 and
ALDH7A1 ) in 77
SCC cases using pyrosequencing ( p = 0.003 ) . -
pubmed
Immunocheckpoint inhibitors including anti -
PD-1 antibody have shown certain therapeutic effects on various
cancer types . -
pubmed
An allosteric
PGAM1 inhibitor effectively suppresses
pancreatic ductal adenocarcinoma . -
pubmed
Glycolytic enzyme
phosphoglycerate mutase 1 (
PGAM1 ) plays a critical role in
cancer metabolism by coordinating glycolysis and biosynthesis . -
pubmed
A well - validated
PGAM1 inhibitor , however , has not been reported for treating
pancreatic ductal adenocarcinoma (
PDAC ) , which is one of the deadliest malignancies worldwide . -
pubmed
By uncovering the elevated
PGAM1 expressions were statistically related to worse prognosis of
PDAC in a cohort of 50
patients , we developed a series of allosteric
PGAM1 inhibitors by structure - guided optimization . -
pubmed
The compound KH3 significantly suppressed proliferation of various
PDAC cells by down - regulating the levels of glycolysis and mitochondrial respiration in correlation with
PGAM1 expression . -
pubmed
Similar to
PGAM1 depletion ,
KH3 dramatically hampered the canonic pathways highly involved in
cancer metabolism and development . -
pubmed
The better responses to KH3 in PDXs were associated with higher expression of
PGAM1 and longer / stronger suppressions of
cancer metabolic pathways . -
pubmed
Taken together , our findings demonstrate a strategy of targeting
cancer metabolism by
PGAM1 inhibition in
PDAC . -
pubmed
METHODS AND RESULTS : BALB / C
mice with TNBS - induced
colitis , when treated with
resveratrol , showed improved clinical outcomes and reduced induction of inflammatory T cells ( Th17 and Th1 ) while increasing
CD4+
Foxp3 + regulatory T cells ( Tregs ) and
IL-10 - producing CD4 + T cells . -
pubmed
OBJECTIVE : We aimed to investigate whether
GRP -
GRPR signaling is altered in
SDH neurons in a
mouse model of chronic
itch and to determine the potential mechanisms underlying these alterations . -
pubmed
RESULTS : We observed potentiation of
GRP - evoked excitation in the
GRPR+ SDH neurons of
mice with
contact dermatitis , without concomitant changes in
GRPR expression . -
pubmed
Furthermore , CRISPR -
Cas9 - mediated astrocyte - selective in vivo editing of a gene encoding
lipocalin-2 (
LCN2 ) , an astrocytic factor implicated in chronic itch , suppressed increases in
GRP - induced excitation of
GRPR+ neurons , repetitive scratching , and
skin damage in
mice with
contact dermatitis . -
pubmed
In addition ,
EEF2 ,
RPL26L1 ,
RPLP0 ,
PRPF8 ,
LSM3 ,
DHX9 ,
RSRC1 , and
AP2B1 might be therapeutic targets for
MDD . -
pubmed
Although the mutation analysis performed on DNA isolated from blood cells and progressed lesion samples confirmed the
tumor to be germline
BRCA wild - type ,
cisplatin monotherapy was administered based on the increasing evidence of safety and efficacy of
platinum for
breast cancer . -
pubmed
Serological tests revealed asymptomatic
anemia and
leukopenia , elevated liver enzymes , and positive antinuclear antibodies ( ANA ) and
anti - SSb / La antibodies . -
pubmed
Cathepsin S is an emerging marker for
ovarian cancer . -
pubmed
Under optimized conditions , in terms of pH and receptor concentration , both biosensors have linear response ranges between LOQ ( 0.14 ng mL-1 ) and 2.5 ng mL-1 , which is suitable for the determination of
Cath S in blood plasma samples of
ovarian cancer patients and healthy
individuals , after corresponding dilution with 0.15 M PBS buffer . -
pubmed
The biosensors were validated by the determination of
Cath S in series of plasma from
ovarian cancer patients and healthy volunteers using both biosensors and ELISA , giving Pearson coefficients close to 1 . -
pubmed
Plasma
Cath S concentration can be used as an
ovarian cancer marker , in view of the highly elevated concentrations detected . -
pubmed
Increases in
pseudouridine excretion suggest increased
tumor transfer ribonucleic acid turnover ; in addition , for the
methylated nucleosides , higher than normal values may reflect enhanced
transfer ribonucleic acid methylase activity of the neoplastic cells . -
pubmed
These analyses plus morphologic and biochemical data support the hypothesis that
VOD is caused by cytoreductive injury to hepatocytes and endothelium in zone three of the liver acinus , and in turn strongly influenced by factors which induce the release of
tumor necrosis factor - alpha (
TNF - alpha ) leading to enhancement or activation of coagulation with obstruction of hepatic sinusoids and venules . -
pubmed
Use of the
TNF - alpha blocker ,
pentoxifylline , has also shown promise in lessening
VOD . -
pubmed
A statistical model which predicts patients likely to have an unfavorable outcome from
VOD has been used to select premorbid
patients for promising new therapeutic modalities , such as recombinant
tissue plasminogen activator . -
pubmed
Studies on two types of
glutaminase in normal and
tumour bearing
mice . -
pubmed
The isolation of these
lymphokines should offer new insights into macrophage receptor - mediated endocytosis , and may yield substances useful in preventing foam cell formation in
atherosclerosis . -
pubmed
With regard to side effects ,
diarrhea developed in 4 cases and
eosinophilia in 6 cases , abnormal simultaneous increases in
GOT and
GPT in 1 case and 1 case each for abnormal values in
LDH and BUN were seen in the clinical test values . -
pubmed
The occurrence of recurrent
bacterial infections ,
neutrophil motility dysfunction and normal expression of
beta 2 integrins (
CD18 ) in two unrelated children suggested an as yet undescribed
adhesion deficiency . -
pubmed
The fact that both children exhibited the rare Bombay blood group and were
Lewis negative , each involving
carbohydrates with different
fucose linkages , suggested a possible defect in the
fucose - containing ligand for
E - and P - selectin , sialyl Lewis X (
SLe ( x ) ) . -
pubmed
The observation that the neutrophils did not bind to recombinant
E - selectin and purified
P - selectin confirmed the
SLe ( x ) deficiency as the basis for
adhesion deficiency . -
pubmed
Low binding of
fucose - specific
lectins to the
patients ' B lymphocytes transformed with
Epstein - Barr virus was observed , while the binding of
mannose - specific lectins was normal , providing further evidence for a general
fucose deficiency as the primary defect . -
pubmed
The existence of the
patients and their deficiency emphasizes the essential role of the endothelial cell
selectins and their ligand ,
SLe ( x ) , in recruitment of neutrophils to sites of
infection . -
pubmed
Gene regulation of
beta-1 - adrenergic receptor in genetically
hypertensive rats . -
pubmed
Relation of
epidermal growth factor receptor concentration to growth of
human esophageal cancer cell lines . -
pubmed
The relation between the concentration of
epidermal growth factor ( EGF ) receptor and the effects of
EGF on cell proliferation were studied using 16 newly established
human esophageal cancer cell lines . -
pubmed
[ The diagnostic values of serum determinations of
troponin T in
acute ischemic cardiopathy ] . -
pubmed
In addition , alterations in the glycosylation of
IgG associated with
rheumatoid arthritis were directly monitored . -
pubmed
RER+ putative
endometrial precancers (
atypical endometrial hyperplasias ) progress to RER+
carcinomas , which retain some of the altered microsatellites acquired in earlier precursor stages . -
pubmed
Eighty - eight selected clinical isolates of
Serratia marcescens , representing 27 putative outbreaks of
nosocomial cross - infection encountered during 1980 - 1995 , were tested comparatively by bacteriocin typing ,
carbon source assimilation tests , serotyping ( O and H antigens ) , and restriction pattern ( RFLP ) analysis of restriction cleaved (
SpeI ,
XbaI ) genomic DNA fragments after pulsed - field gel electrophoresis ( PFGE ) . -
pubmed
We will discuss our work suggesting that both
CD4 and
CD8 cells specific for different
TCR determinants on the
V beta 8.2 chain are involved in the regulation of MBP - specific CD4 T cells mediating experimental
autoimmune encephalomyelitis . -
pubmed
Genetic characterization of the
nef gene from
human immunodeficiency virus type 1 group M strains representing genetic subtypes A , B , C , E , F , G , and H. Most efforts to characterize sequence variation of
HIV isolates has been directed toward the structural envelope gene . -
pubmed
Interferon - alpha2a reduces MRI disease activity in
relapsing - remitting multiple sclerosis . -
pubmed
Norwegian Study Group on
Interferon - alpha in
Multiple Sclerosis . -
pubmed
OBJECTIVE : To evaluate the efficacy and safety of
interferon - alpha2a (
IFN - alpha2a ) in
relapsing - remitting MS (
RRMS ) . -
pubmed
BACKGROUND : Several immune - modulating therapy regimens of
IFN - alpha have shown varying results in
MS . -
pubmed
Agrin is a major
heparan sulfate proteoglycan accumulating in
Alzheimer ' s disease brain . -
pubmed
Proliferating cell nuclear antigen expression in
Wilms ' tumor : a comparative study of pre- and post - chemotherapy specimens . -
pubmed
A total of 36
Wilms ' tumors were immunohistochemically analyzed for proliferative (
proliferating cell nuclear antigen - labeling ) index ( PI ) with special reference to the effect of preoperative chemotherapy on the proliferative potential of
tumors and differences in PI according to the histologic components ( epithelial , blastemal and stromal ) . -
pubmed
We have previously demonstrated that the protein encoded by the
retinoblastoma susceptibility gene (
Rb ) functions as a regulator of transcription by
RNA polymerase I ( rDNA transcription ) by inhibiting
UBF - mediated transcription . -
pubmed
Four different genes , the
amyloid precursor protein ,
apolipoprotein E , and
presenilins 1 and 2 have been implicated in the etiology of
familial AD . -
pubmed
MOv18 antibody binds the membrane
folate receptor highly expressed on ovarian
carcinoma cells . -
pubmed
Although induction of T cell responses to fed
Ag ( oral tolerance ) is thought to happen within the organized lymphoid tissue of the gut , we found that
mice lacking Peyer 's patches , B cells , and the specialized
Ag - handling M cells had no defect in the induction of T cell responses to fed
Ag , whether assayed in vitro by T cell proliferation or
cytokine production , or in vivo by delayed - type
hypersensitivity or bystander suppression against
mycobacterial Ags in CFA . -
pubmed
Factor VII deficiency is a serious , potentially lethal disorder of
blood coagulation caused by a defect in
hepatic factor VII synthesis . -
pubmed
During
papillomavirus infection , the
E5 protein localizes in the cell Golgi apparatus and other endomembrane compartments . -
pubmed
Cell viability and
cytotoxicity were assessed by
dimethylthiazolyldiphenyltetrazolium bromide (
MTT ) testing and quantification of
lactate dehydrogenase . -
pubmed
In the Danish cohort ( n = 306 ) of the Early Postmenopausal Intervention Cohort ( EPIC ) Study ( n = 1609 ) of oral
alendronate (
ALN ) for prevention of
postmenopausal osteoporosis , bone markers (
urine C - telopeptides of
type I collagen (
uCTX ) , urine N - telopeptide cross - links of
type I collagen (
uNTX ) , serum total
osteocalcin measured by ELISA [ total OC ( ELISA ) ] , and serum total
osteocalcin measured by RIA [ total OC ( RIA ) ] ) were measured at 6 - month intervals . -
pubmed
Vascular endothelial growth factor assessment in different blood fractions of
gastrointestinal cancer patients and healthy controls . -
pubmed
Vascular endothelial growth factor (
VEGF ) is known to play a central role in
tumour angiogenesis . -
pubmed
The aims of this pilot study were to assess
VEGF in blood compartments of 16 healthy control
volunteers and 56
gastrointestinal cancer patients , prospectively collected , to identify the most suitable blood fraction for the determination of
VEGF and to evaluate its possible clinical - biological significance . -
pubmed
The best differentiation between healthy control
volunteers and
cancer patients in
VEGF level was seen for P - APRCTAD ( mean value : 278 pg / ml vs 77 pg / ml ; p=0.0036 by t - test ) . -
pubmed
Patients were evaluated for survival , quality of life , liver function ,
tumor mass , toxicity related to the treatment and
retinoid receptors in liver biopsies . -
pubmed
In addition to the diagnostic criteria for
APS a heterozygous
factor V Leiden mutation was found in this patient , which may be a contributing risk factor for
cerebral ischemia . -
pubmed
Editorial :
HRPT2 in
parathyroid cancer : a piece of the puzzle . -
pubmed
However , additional comprehensive studies are required to further validate the technique and allow its entrance in mainstream diagnostic use , particularly for non -
IgE - mediated
hypersensitivity . -
pubmed
Transgenic overproduction of
murine 60 kDa heat shock protein in the liver does not prevent
type I diabetes in NOD
mice . -
pubmed
Telomerase activity in disseminated
prostate cancer cells . -
pubmed
OBJECTIVE : To analyse
telomerase activity in disseminated
prostate cancer cells isolated from bone marrow aspirates taken from
men with
localized prostate cancer before radical prostatectomy ( RP ) . -
pubmed
Telomerase activity in the 35 samples was not significantly associated with Gleason score , preoperative
prostate - specific antigen level ,
tumour stage , or surgical margin status . -
pubmed
Compared to tissue staining , where
telomerase is detected in 80 - 90 % of samples , we found lower rates of
telomerase activity in the disseminated
tumour cells ( 49 % ) . -
pubmed
Telomerase - negative cells might provide information about cell dormancy , as
telomerase is a marker of cell proliferation in immortal and
cancer cells . -
pubmed
Metalloproteinases (
MMPs ) are responsible by remodeling ECM in many
neuromuscular disorders . -
pubmed
Secretion of
celiac disease autoantibodies after in vitro
gliadin challenge is dependent on
small - bowel mucosal transglutaminase 2 - specific
IgA deposits . -
pubmed
BACKGROUND : In
celiac disease gluten , the disease - inducing toxic component in
wheat , induces the secretion of autoantibodies which are targeted against
transglutaminase 2 (
TG2 ) . -
pubmed
Since the mucosal autoantibodies disappear slowly after a gluten - free diet , our aim was to establish whether autoantibody secretion to organ culture supernatants in treated
celiac disease patient biopsies is related to the duration of the diet and further to the pre - existence of mucosal
TG2 - specific
IgA deposits in the cultured biopsy samples . -
pubmed
RESULTS : In the organ culture system conducted with biopsies derived from treated
celiac disease patients ,
gliadin induced secretion of autoantibodies to culture supernatants , reduced epithelial cell height and increased the density of lamina proprial CD25 + cells . -
pubmed
However , these changes could be demonstrated only in biopsies from short - term treated
celiac disease patients , where the small - intestinal mucosal
TG2 - specific
IgA autoantibody deposits were still present . -
pubmed
CONCLUSION : Our results show that studies focusing on the toxic effects of
gliadin in the organ culture system should be carried out with biopsy samples from short - term treated
celiac disease patients who are likely still to have mucosal
IgA deposits present . -
pubmed
Endonuclease G expression in thalamic reticular nucleus after global
cerebral ischemia . -
pubmed
Endonuclease G is a mitochondrial enzyme , known to be translocated to the nucleus after transient focal
cerebral ischemia and contribute to DNA degradation . -
pubmed
The purpose of this study was to identify if
Endonuclease G was expressed in the cell nucleus of
parvalbumin(+ ) GABA'ergic neurons in relation to cell death after global
cerebral ischemia in the thalamic reticular nucleus . -
pubmed
Eosinophilic neurons and vacuolization of the cytoplasm in
parvalbumin(+ ) neurons were observed 2 days after
ischemia . -
pubmed
Endonuclease G immunoreactivity increased in the cytoplasm 12 h after
ischemia and was translocated to the nucleus of
parvalbumin(+ ) neurons after 24 h. In the nucleus of astroglia ,
Endonuclease G was expressed after 2 days with an apoptotic - like morphology and the number of
Endonuclease G - expressing astroglia increased during the later time points . -
pubmed
In conclusion , this study has identified that
Endonuclease G is translocated from the cytoplasm to the nucleus of neurons and expressed with apoptotic - like morphology in the nucleus of astroglia in the thalamic reticular nucleus after global
cerebral ischemia . -
pubmed
A quantitative inverse relationship between
connexin32 expression and cell proliferation in a
rat hepatoma cell line . -
pubmed
[ Study on the progress of the mechanism of
TGF - beta in the
scarring and the effect of TCM ] . -
pubmed
Transforming growth factor ( TGF - beta ) plays a central role in
wound healing and
scarring . -
pubmed
TCM can reduce the expression of
TGF - beta , resistance of
fibrosis , so that lighten the development of
scar . -
pubmed
This article reviewed the mechanism of
TGF - beta in the
scarring and
TCM can decrease the development of
scar effected by
TGF - beta . -
pubmed
Increased
urokinase - type plasminogen activator receptor and
epidermal growth factor receptor in serum of
patients with
prostate cancer . -
pubmed
PURPOSE :
Prostate cancer cell motility and invasion have been linked to the up - regulated signaling of
epidermal growth factor receptor and
urokinase - type plasminogen activator receptor . -
pubmed
We analyzed the expression of
serum urokinase - type plasminogen activator receptor and
epidermal growth factor receptor in the serum of
patients with clinical suspicion of
prostate cancer to evaluate the possible role as
prostate cancer markers . -
pubmed
RESULTS : The 30
patients with
prostate cancer had significantly higher levels of serum
urokinase - type plasminogen activator receptor and
epidermal growth factor receptor in comparison to those without
prostate cancer but not significantly higher levels of
prostate specific antigen . -
pubmed
Urokinase - type plasminogen activator receptor and
epidermal growth factor receptor levels closely correlated in the serum of
patients with
prostate cancer . -
pubmed
ROC analysis revealed that
serum epidermal growth factor receptor had 93.3 % sensitivity and 98 % specificity for detecting
prostate cancer at a cutoff of 67.9 ng / ml . -
pubmed
CONCLUSIONS : The measurement of
urokinase - type plasminogen activator receptor and
epidermal growth factor receptor in the serum of
patients with clinical suspicion of
prostate cancer might provide clinically relevant information on the state of the prostate gland . -
pubmed
Measuring
serum epidermal growth factor receptor could help predict which
patients have
prostate cancer , while serum
urokinase - type plasminogen activator receptor over expression seems to be related to
tumor extraprostatic spread . -
pubmed
The effects of the
opiate receptor antagonist
naloxone were tested on neurohypophyseal VP release during
dehydration ,
ethanol administration and
sulphated cholecystokinin octapeptide (
CCK-8S ) application , assuming that the inhibition of pituitary OT release by endogenous opioids increases as neurohypophyseal VP output increases . -
pubmed
The data indicate that opioid peptides co - released with VP ( like
dynorphin ) may be responsible for cross - inhibition of
OT release during
dehydration . -
pubmed
Carotid atherosclerosis progression and
ACAT inhibition . -
pubmed
micRo - manageMeNT of
MYC during
hypoxia . -
pubmed
Comparison of the post - meal
glucose response to different
insulin bolus waveforms in
insulin pump- and pre - meal pramlintide - treated
type 1 diabetes patients . -
pubmed
CONCLUSIONS : For currently available
insulin pump bolus waves , SQ and MC may be least likely to cause
hypoglycemia in
pramlintide - treated
patients . -
pubmed
This effect , or a
sid-1(- ) background , can be used to uncover
neuronal defects for lethal genes . -
pubmed
PARTICIPANTS : Sixty - nine
individuals ( 41
women , 28
men ; mean age 77.78 years , standard deviation 6.32 , range = 56 - 89 ) with a diagnosis of
AD or mixed
AD and
vascular dementia and a Mini - Mental State Examination score of 18 or above , and receiving a stable dose of
acetylcholinesterase - inhibiting medication . -
pubmed
Anti -
DLL4 , a
cancer therapeutic with multiple mechanisms of action . -
pubmed
Because of the importance of Notch signaling in stem cell biology ,
DLL4 has been investigated for its role in the maintenance and proliferation of
cancer stem cells ( CSC ) . -
pubmed
Preclinical studies have highlighted that both anti - CSC and anti - angiogenic activities contribute to its anti - tumor efficacy , and have supported the clinical development of anti -
DLL4 antibody for the treatment of
cancer . -
pubmed
This study examined viral replication ,
cytotoxicity and
cytokine production in cultures of primary AECs from
children compared with responses to
RSV infection in an
immortalised epithelial cell line and to those from infants with
RSV bronchiolitis . -
pubmed
METHODS :
RSV replication , proinflammatory
cytokine responses and cytotoxicity in
RSV - infected primary AEC cultures derived from bronchial brushings from the lungs of children were compared with those seen in
BEAS-2B cultures , as well as AECs and bronchoalveolar lavage fluid collected from
children with and without
RSV bronchiolitis . -
pubmed
RESULTS : Viral replication ,
cytotoxicity and inflammatory
cytokine production were greater in
primary AEC cultures than in
BEAS-2B cells . -
pubmed
Some primary AEC culture immunological responses , such as
interleukin 8 , were similar in magnitude to those seen in clinical samples from the lungs of children with
RSV bronchiolitis . -
pubmed
DISCUSSION : The real - time PCR is a rapid and reliable method for detecting gene polymorphisms on the AGT M235 T , the A ( -6 ) G and A ( -20 ) C. CONCLUSION : this method of real - time PCR is a reliable genetic test , which is fast and cheap and can be used in practice to study particular polymorphisms of
AGT gene associated with
cardiovascular disease . -
pubmed
BRAF inhibitors and
melanoma . -
pubmed
Selective
BRAF inhibitors have recently emerged as a new standard treatment for
patients with
metastatic melanoma harboring activating
BRAF mutations . -
pubmed
Over - expression of anti - apoptotic
BCL2 has been reported in
chronic lymphocytic leukaemia (
CLL ) , but targeting
BCL2 alone did not yield appreciable clinical results . -
pubmed
Lenalidomide , an immunomodulator , is clinically effective in
CLL and can enhance the anti - CLL effects of
CD20 targeting monoclonal antibody , rituximab . -
pubmed
Here , we investigated the mechanism of immune - directed killing of
lenalidomide in
CLL and evaluated if concurrent targeting of
CD20 and
BCL2 can enhance this effect . -
pubmed
This effect was further enhanced with pre - treatment of
tumour cells with
AT-101 ( a BH3 mimetic that functions as
BCL2 antagonist ) . -
pubmed
Consistent with previous reports on
ephrin - B2 induction in some
epithelial tumors and tumor - associated vasculatures ,
EC8 specifically detected
ephrin - B2 in
tumors as well as the vasculature within and outside of the
tumors . -
pubmed
These results indicate that
Comp.1 and
Comp.2 have neurotrophic effects , and have the potential for disease modification in
depression and
dementia . -
pubmed
By functional analysis of
DeltaMoatg1 and
DeltaMoatg4 mutants , we demonstrate that infection - associated
nuclear degeneration in
M. - pubmed
Previous studies with
glioma cell lines such as
NG108 - 15 cells attributed
morphine - induced gene expression to the activation of the
cAMP - responsive element binding protein (
CREB ) . -
pubmed
Baseline platelet counts between 50,000 and 100,000 / mul independently predicted
bleeding [ adjusted HR 2.89 ( 1.76 , 4.73 ) p & lt ; 0.001 ] as did
esophageal varices ,
hemoglobin & lt;= 9.9 g % , and INR 1.4 - 2.0 . -
pubmed
The pharmacokinetic studies indicated that
KCN1 could be detected in all of the tissues examined , most for at least 24 h. In conclusion , our preclinical data indicate that
KCN1 is a potential therapeutic agent for
pancreatic cancer , providing a basis for its future development . -
pubmed
In the following editorial , we will briefly describe new classes of potential bronchodilators including : novel
PDE inhibitors , natural phytotherapeutics ,
bitter taste receptor ligands , and
chloride channel modulators , which have the potential to be used alone or in combination with existing bronchodilators to reverse
acute airway obstruction in the future . -
pubmed
We used the UC
rat model by immunological sensitization combined with local
2 , 4 , 6 - trinitrobenzene sulfonic acid (
TNBS ) in 50 %
ethanol enema , observed dynamically animal general state and body weight , examined the histological and functional changes in the colon , lung , liver , and kidney tissues , and detected microvascular endothelium response towards
inflammation characterized with the expression of
iNOS ,
TXB2 ,
P - selectin ,
ICAM-1 , and
vascular endothelial growth factor A (
VEGF - A ) in the colon and lung tissue . -
pubmed
Single nucleotide mutations in the
iduronate 2 - sulfatase (
IDS ) gene at Xq28 most commonly cause
Hunter syndrome while a CGG expansion in the
FMR1 gene at Xq27.3 is associated with
Fragile X syndrome . -
pubmed
CASE PRESENTATION : We describe the clinical , molecular and biochemical evaluations of a four year - old female patient with global
developmental delay and a hemizygous deletion of Xq27.3q28 ( 144,270,614 - 154,845,961 bp ) , a 10.6 Mb region that contains & gt;100 genes including
IDS and
FMR1 . -
pubmed
A literature review revealed rare cases with similar deletions that included
IDS and
FMR1 in females with
developmental delay , variable features of
Hunter syndrome , and skewed X - inactivation of the normal X chromosome . -
pubmed
Moreover ,
integrin beta1 , through its abilities to activate latent
TGFbeta1 and promote
collagen production through
focal adhesion kinase / rac1 / nicotinamide adenine dinucleotide phosphate oxidase (
NOX)/reactive
oxygen species ( ROS ) , is essential for dermal homeostasis , repair and
fibrosis . -
pubmed
The
integrin beta1 - interacting protein
CCN2 , a member of the CCN family of proteins , is induced by
TGFbeta1 ; yet ,
CCN2 is not a simple downstream mediator of
TGFbeta1 , but instead synergistically promote
TGFbeta1 - induced adhesive signaling and
fibrosis . -
pubmed
Stress - inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to
ischemia via the
prion protein . -
pubmed
Rescue of
embryonic lethality in these mutants , by transgenic expression of the
STI1 gene , supported a unique role for
STI1 during embryonic development . -
pubmed
At the cellular level ,
ischemia increased the secretion of
STI1 from wild - type astrocytes by 3 - fold , whereas
STI1 haploinsufficient
mice secreted half as much
STI1 . -
pubmed
Interesting , extracellular
STI1 prevented
ischemia - mediated neuronal death in a prion protein - dependent way . -
pubmed
Downregulation of miR-15a due to
LMP1 promotes cell proliferation and predicts poor prognosis in nasal
NK / T - cell lymphoma . -
pubmed
In
NNKTL tissues , we found that reduced miR-15a expression , which correlated with
MYB and
cyclin D1 expression , was associated with poor prognosis of
NNKTL patients . -
pubmed
These data suggest that downregulation of miR-15a , possibly due to
LMP1 , implicates in the pathogenesis of
NNKTL by inducing cell proliferation via
MYB and
cyclin D1 . -
pubmed
Anaphylactic responses to
histamine in
mice utilize both
histamine receptors 1 and 2 . -
pubmed
Despite clinical use of both
H1R and
H2R blockers in the therapy for
acute allergic reactions , there is little mechanistic evidence to support the necessity for blocking
H2R , a receptor best characterized for its role in stomach acid production . -
pubmed
METHODS : Here , we sought to define the necessity for
histamine receptors in the pathology of
anaphylaxis using
H1R and
H2R knockout ( KO )
mice , as well as a
H1R /
H2R double KO strain . -
pubmed
RESULTS : In response to
IgE - mediated systemic
anaphylaxis , the symptoms and decreases in core body temperature observed in wild - type
mice were reduced but not ablated in either
H1R or
H2R KO . -
pubmed
Intravenous injection of
histamine was sufficient to elicit these responses , and similar to
IgE - mediated
anaphylaxis , loss of both
H1R and
H2R was necessary for complete protection . -
pubmed
CONCLUSION : Our data demonstrate definitively that both
H1R and
H2R participate in the immediate systemic responses during
histamine - associated pathophysiology and mechanistically support the utility of
H2R - blocking therapeutics in alleviating symptoms of
anaphylaxis . -
pubmed
For
patients exposed to ERT , the magnitude of the
CD4 + depletion peaked 6 months after their
cancer diagnosis ( mean
CD4 + drop at this time = -283 + - 370 cells / mm(3 ) ) . -
pubmed
CONCLUSIONS : In PLHIV ,
cancer treatment increased the risk for prolonged
CD4 + depletion and virological failure but had no impact on
AIDS - related events when appropriate prophylaxes were implemented . -
pubmed
This study reviews the clinical manifestations of
fragile X - associated disorders as well as the spectrum of mutations of the
fragile X mental retardation 1 gene (
FMR1 ) and the neurobiology of the
fragile X mental retardation protein (
FMRP ) , and also provides an overview of the potential therapeutic targets and genetic counselling . -
pubmed
It is believed that CGG repeat expansions in the premutation range ( 55 to 200 repeats ) elicit an increase in mRNA levels of
FMR1 , which may cause
neuronal toxicity . -
pubmed
Aryl Hydrocarbon Receptor Activation Down - Regulates
IL-7 and Reduces Inflammation in a
Mouse Model of DSS - Induced
Colitis . -
pubmed
Aryl hydrocarbon receptor (
AHR ) is believed to control the
chronic inflammation in the gut . -
pubmed
Besides ,
interleukin-7 (
IL-7 ) is proved to be an important
cytokine that activates mucosal
inflammation in
IBD . -
pubmed
In this study , we investigated the function of
6 - formylindolo ( 3,2 - b ) carbazole (
Ficz ) , a ligand of
AHR , on
IL-7 ,
colitis , and IEL phenotypes . -
pubmed
RESULTS : Ficz down - regulated epithelial - derived
IL-7 expression in
mice with DSS - induced
colitis and ameliorated DSS - induced
colitis . -
pubmed
CONCLUSIONS : Ficz could down - regulate epithelial - derived
IL-7 expression in
mice with DSS - induced
colitis and inhibit
inflammation in the gastrointestinal tract of
mice . -
pubmed
AHR - related compounds might be the new and promising therapeutic medicaments for the treatment of
patients with
IBD . -
pubmed
[ Effectiveness and safety of initiation of once - daily
insulin detemir in Chinese
patients with
type 2 diabetes previously treated with different quantities of oral anti - diabetic drugs : subgroup analysis of the Chinese SOLVE Study ] . -
pubmed
OBJECTIVE : To evaluate the effectiveness and safety on once - daily ( OD )
insulin detemir ( IDet ) in Chinese
patients with
type 2 diabetes mellitus (
T2DM ) who were treated with different types or combinations of oral anti - diabetic drugs ( OADs ) . -
pubmed
Effects of
Hypericum perforatum extract and its main bioactive compounds on the
cytotoxicity and expression of
CYP1A2 and
CYP2D6 in hepatic cells . -
pubmed
Corrigendum to "
GK-1 Improves the Immune Response Induced by Bone Marrow Dendritic Cells Loaded with
MAGE - AX in
Mice with
Melanoma " . -
pubmed
How
Melanoma Resists
PD-1 Blockade . -
pubmed
Researchers at the University of California , Los Angeles , have shed light on mechanisms by which
melanoma cells become resistant to
PD-1 blockade with pembrolizumab . -
pubmed
Antimetastatic effects of
cordycepin mediated by the inhibition of mitochondrial activity and
estrogen - related receptor alpha in
human ovarian carcinoma cells . -
pubmed
After 24 h treatment ,
cordycepin suppresses epithelial - mesenchymal transition and migration in
ovarian carcinoma cells through inhibiting
estrogen - related receptor ( ERR )- alpha . -
pubmed
EZH2 is a potential therapeutic target for
H3K27M - mutant pediatric gliomas . -
pubmed
Nearly 80 % of
DIPGs harbor mutations in
histone H3 genes , wherein lysine 27 is substituted with methionine ( H3K27 M ) . -
pubmed
Furthermore , we demonstrate that small - molecule
EZH2 inhibitors abolish
tumor cell growth through a mechanism that is dependent on the induction of the tumor - suppressor protein
p16INK4A. -
pubmed
Furthermore , we find a highly significant overlap between genes that retain H3K27me3 in the
DIPG mouse model and in
human primary
DIPGs expressing
H3K27M. -
pubmed
Taken together , these results show that residual PRC2 activity is required for the proliferation of
H3K27M - expressing
DIPGs , and that inhibition of
EZH2 is a potential therapeutic strategy for the treatment of these
tumors . -
pubmed
Immunomodulation of
autoimmune arthritis by pro - inflammatory
cytokines . -
pubmed
Pro - inflammatory
cytokines promote
autoimmune inflammation and
tissue damage , while anti - inflammatory
cytokines help resolve
inflammation and facilitate tissue repair . -
pubmed
Studies conducted by others and us in experimental models of
arthritis involving direct administration of
IFN - gamma or
TNF - alpha ; in vivo neutralization of the
cytokine ; the use of
animals deficient in the
cytokine or its receptor ; and the impact of the
cytokine or anti -
cytokine therapy on defined T cell subsets have revealed paradoxical anti - inflammatory and immunoregulatory attributes of these two
cytokines . -
pubmed
Similar studies in other models of
autoimmunity as well as limited studies in
arthritis patients have also unveiled the disease - protective effects of these pro - inflammatory
cytokines . -
pubmed
Nevertheless , the realization that pro - inflammatory
cytokines can also be immunoregulatory offers a new perspective in fully understanding the pathogenesis of
autoimmune diseases and in designing better therapies for controlling them . -
pubmed
P2X7 receptor antagonism : Implications in
diabetic retinopathy . -
pubmed
Recently , an important link between
P2X7 receptor (
P2X7R ) and
inflammation has been demonstrated indicating this receptor as potential pharmacological target in
DR . -
pubmed
As an in vitro model of early
diabetic retinopathy ,
human retinal pericytes were exposed to high
glucose ( 25mM , 48h ) that caused a significant ( p<0.05 ) release of
IL-1beta and
LDH . -
pubmed
Overall , our findings suggest that the
P2X7R represents an attractive pharmacological target to manage the early phase of
diabetic retinopathy , and the compound
JNJ47965567 is a good template to discover other
P2X7R selective antagonists . -
pubmed
SUMMARY : A 62 - year - old
woman with a grade 1 metastatic
pancreatic neuroendocrine tumor (
pNET ) developed bilateral lower extremity
edema and
pain approximately 4 months after initiation of treatment with
everolimus , an inhibitor of mammalian ( or mechanistic ) target of
rapamycin (
mTOR ) . -
pubmed
A hypothesized mechanism for
everolimus - induced
bone pain includes marrow
edema and
hyperemia from reduced intraosseous perfusion , which have been previously reported in association with
mTOR inhibitor use . -
pubmed
PrPSc ( scrapie isoform of the
prion protein ) prions are the infectious agent behind diseases such as
Creutzfeldt - Jakob disease in
humans ,
bovine spongiform encephalopathy in
cattle ,
chronic wasting disease in
cervids (
deer ,
elk ,
moose , and
reindeer ) , as well as
goat and
sheep scrapie . -
pubmed
Early postnatal soluble
FGFR3 therapy prevents the atypical development of
obesity in
achondroplasia . -
pubmed
We have thus decided to study
obesity in
patients and to use the
mouse model to evaluate if soluble
FGFR3 therapy , an innovative treatment approach for
achondroplasia , could also impact the development of this significant complication . -
pubmed
These results were validated in a
murine model of
achondroplasia (
Fgfr3ach/+ ) where similar visceral adiposity was observed . -
pubmed
Glucose ,
insulin or lipid levels remained low , without the development of
diabetes . -
pubmed
Very interestingly , in
achondroplasia mice treated with soluble
FGFR3 during the growth period ( from D3 to D22 ) , the development of these metabolic deregulations was prevented in adult
animals ( between 4 and 14 weeks of age ) . -
pubmed
These results suggest that
achondroplasia induces an uncommon metabolism of energy , directly linked to the
FGFR3 mutation . -
pubmed
In this context ,
sFGFR3 proved to be a promising treatment for
achondroplasia by normalizing the biology at different levels , not only restoring bone growth but also preventing the atypical
visceral obesity and some metabolic deregulations . -
pubmed
A 36 - year - old
woman with
JIA who was treated with tocilizumab targeting
interleukin-6 ( IL-6 ) receptor underwent ABO - incompatible kidney transplantation ( ABOi KTx ) . -
pubmed
Both serum
IL-6 and soluble
IL-6 receptor levels were markedly decreased , suggesting that multitargeted immunosuppression for ABOi KTx induced long - term clinical remission of
JIA through inhibition of the
IL-6 pathway . -
pubmed
,
Lynch syndrome ) , such as
MSH6 ( 4.8 % vs. 1.2 % , p = .005 ) ,
MSH2 ( 2.7 % vs. 0.0 % , p = .004 ) ,
POLE ( 1.6 % vs. 0.0 % , p = .008 ) ,
NF1 ( 5.9 % vs. 0.5 % , p & lt ; .001 ) ,
SMAD4 ( 14.3 % vs. 8.3 % , p = .024 ) , and
BRCA2 ( 3.7 % vs. 0.5 % , p = .002 ) . -
pubmed
ADAR1 - mediated RNA - editing of 3'UTRs in
breast cancer . -
pubmed
BACKGROUND : Whole transcriptome RNA variant analyses have shown that
adenosine deaminases acting on RNA (
ADAR ) enzymes modify a large proportion of cellular RNAs , contributing to transcriptome diversity and
cancer evolution . -
pubmed
Despite the advances in the understanding of
ADAR function in
breast cancer ,
ADAR RNA editing functional consequences are not fully addressed . -
pubmed
In addition ,
tumors from the
BRCA TCGA cohort show a 24 % increase in editing over
normal breast samples when looking at 571 well - characterized UTRs targeted by
ADAR1 . -
pubmed
Basal - like subtype
breast cancer patients with high level of
ADAR1 mRNA expression shows a worse clinical outcome and increased editing in their 3'UTRs . -
pubmed
Interestingly , editing was particularly increased in the 3'UTRs of
ATM ,
GINS4 and
POLH transcripts in
tumors , which correlated with their mRNA expression . -
pubmed
We confirmed the role of
ADAR1 in this regulation using a shRNA in a
breast cancer cell line (
ZR-75 - 1 ) . -
pubmed
CONCLUSIONS : Altogether , these results revealed a significant association between the mRNA editing in genes related to
cancer - relevant pathways and clinical outcomes , suggesting an important role of
ADAR1 expression and function in
breast cancer . -
pubmed
Cortical
D2 dopamine receptor (
Drd2 ) have mostly been examined in the context of cognitive function regulation and neurotransmission modulation of medial prefrontal cortex by principal neurons and
parvalbumin positive , fast - spiking , interneurons in
schizophrenia . -
pubmed
These results pave the way for a thorough re - examination of cortical
D2 receptor functions , which could provide information about neuronal circuits involved in
psychotic and mood disorders . -
pubmed
Expression of
amino acid transporter (
LAT1 and
4F2hc ) in
pulmonary pleomorphic carcinoma . -
pubmed
Amino acid transporters are necessary for
tumor growth , metastasis , and survival of various
neoplasms ; however , the clinicopathological significance of
L - type amino acid transporter 1 (
LAT1 ) and
4F2 cell surface antigen (
4F2hc ) in
patients with
pulmonary pleomorphic carcinoma (
PPC ) remainsunknown . -
pubmed
The expression of
LAT1 and
4F2hc , and
Ki-67 labeling index were investigated using specimens of the resected
tumors . -
pubmed
LAT1 and
4F2hc were highly expressed in 35 % and 53 % of all
patients ( n = 105 , P & lt ; .01 ) , 25 % and 48 % of
patients with an
adenocarcinoma component ( n = 48 , P = .02 ) , and 44 % and 58 % of
patients with a
nonadenocarcinoma component ( n = 57 , P = .18 ) , respectively . -
pubmed
A high
LAT1 expression was significantly related to advanced disease , lymphatic permeation ,
tumor cell proliferation , and
4F2hc expression . -
pubmed
LAT1 is highly expressed in
PPC , and high
LAT1 expression can serve as a significant predictor linked to a worse prognosis in
patients with
PPC . -
pubmed
Sex - Dependent Effects of
Bmal1 - Deficiency on
Mouse Cerebral Cortex Infarction in Response to Photothrombotic
Stroke . -
pubmed
Therefore , we studied
infarction in cerebral neocortex of male and female
mice with deletion of the clock gene
Bmal1 (
Bmal1-/- ) after focal
ischemia induced by
photothrombosis ( PT ) . -
pubmed
However , when sexes were analyzed separately 14 days after PT ,
infarct core was significantly larger in wild - type (
Bmal1+/+ ) female as compared to male
Bmal1+/+
mice , and in female
Bmal1+/+ , as compared to female
Bmal1-/-
mice . -
pubmed
Alterations in
beta - catenin , microsatellite instability , and
HNF-1beta levels are independently associated with
ovarian endometriosis - associated tumorigenesis . -
pubmed
Alterations in
beta - catenin ( encoded by
CTNNB1 ) and
microsatellite instability ( MSI ) , as well as changes in the expression levels of
HNF-1beta and DNA mismatch repair (
MMR ) proteins were investigated in 50
OEmCas and 21 OCCCas with
endometriotic lesions . -
pubmed
Mutations of
CTNNB1 were identified in 28 ( 56 % ) of the 50
OEmCa cases and 26 ( 41.9 % ) of the 62 coexisting
endometriosis lesions . -
pubmed
MSI - high ( H ) was observed in 7 ( 14.6 % ) of the 48
OEmCa and 14 ( 23.3 % ) of the 60 coexisting
endometriosis , and was significantly associated with loss of
MMR protein expression , but not
CTNNB1 mutations . -
pubmed
Nonidentical
CTNNB1 status between 2 different epithelial
lesions within
endometriosis was observed in 8 of 10 informative
endometriosis cases that had adjacent OEmCa . -
pubmed
In contrast , high
HNF-1beta expression was significantly associated with
SLC3A1 expression , which plays a major role in
HNF-1beta - triggered induction of reactive
oxygen species in
OCCCas , independent of abnormalities in both
beta - catenin and MSI /
MMR status . -
pubmed
Finally , 4 inflammatory parameters associated with repeated
hemorrhaging in
endometriosis were significantly higher in
endometriosis with
MSI - high when compared with that with
MSS , independent of both
beta - catenin and
HNF-1beta status . -
pubmed
In conclusion , different molecular pathways including alterations in
beta - catenin , MSI , and
HNF-1beta levels may contribute to tumorigenesis in
endometriosis - associated carcinoma . -
pubmed
While it was long held that T cells were the primary mediators of
multiple sclerosis (
MS ) pathogenesis , the beneficial effects observed in response to treatment with Rituximab (
RTX ) , a
monoclonal antibody (
mAb ) targeting
CD20 , shed light on a key contributor to
MS that had been previously underappreciated : B cells . -
pubmed
Neurexophilin and
PC - esterase domain family member 4 (
NXPE4 ) and
prostate androgen - regulated mucin - like protein 1 (
PARM1 ) as prognostic biomarkers for
colorectal cancer . -
pubmed
Neurexophilin and
PC - esterase domain family member 4 (
NXPE4 ) and
prostate androgen - regulated mucin - like protein 1 (
PARM1 ) were two outstanding independent overall survival ( OS ) and relapse - free survival ( RFS ) prognostic genes of
CRC in TCGA database . -
pubmed
We next verified the expression of
NXPE4 and
PARM1 messenger RNA ( mRNA ) levels were significantly lower in
CRC tumor tissue than in the adjacent
noncancerous tissue in our clinical samples , and
NXPE4 mRNA expression level was related to the
tumor location and
tumor size , while
PARM1 was related to
tumor location , lymph nodes metastasis , and
tumor size . -
pubmed
This study demonstrated that
NXPE4 and
PARM1 might be two potential novel prognostic biomarkers for
CRC . -
pubmed
Furthermore , we analyzed the properties of
ASLMN and discovered that six lncRNAs ( MSTRG.10603.16 , 5258.4 , 12799.3 , 5352.1 , 12022.1 , and 12250.4 ) were highly related to
AS through topological analysis . -
pubmed
GO and KEGG enrichment analysis indicated that lncRNA MSTRG.5258.4 may downregulate inducible co - stimulator to perform a downregulated role in
AS through
T cell receptor signaling pathway and downregulate
THBS1 to conduct a upregulated function in
AS through ECM - receptor interaction pathway . -
pubmed
NE- or
ARs agonists - induced
SAP originated from unifocal ectopic foci with predominant localization in the region surrounding PV mouth , but not in the distal portions of a
murine PV myocardium . -
pubmed
Rescue of
cognitive deficits in
APP /
PS1 mice by accelerating the aggregation of beta - amyloid peptide . -
pubmed
Soluble oligomers formed during the process that causes
beta - amyloid (
Abeta ) to aggregate into plaques are considered to have major
neurotoxicity . -
pubmed
By using cell experiments , we determined whether
ZGM1 can inhibit the
cytotoxicity of
Abeta . -
pubmed
Animal experiments showed that
ZGM1 can significantly improve
cognitive dysfunction and that
Abeta plaque deposition in the brain tissue of
mice in the drug - administered group was significantly increased . -
pubmed
CONCLUSION : Our research suggests that promoting
Abeta aggregation is a promising treatment method for
AD and deserves further investigation . -
pubmed
In
humans , the
ovarian tumor protease (
OTU ) subfamily of DUBs includes 16 members , most of which mediate cell signaling cascades . -
pubmed
Even though WHO criteria define
anemia as a
hemoglobin serum concentration < 12 g / dL in women and < 13 g / dL in men , several authors propose different and specific cut - off values for the elderly . -
pubmed
Relating to the molecular mechanism in
Iron Deficiency Anemia (
IDA ) ,
hepcidin has a key role in
iron homeostasis . -
pubmed
Affinity - Enhanced Multimeric
VEGF (
Vascular Endothelial Growth Factor ) and
PlGF (
Placental Growth Factor ) Variants for Specific Adsorption of
sFlt-1 to Restore Angiogenic Balance in
Preeclampsia . -
pubmed
An excess of placental expressed antiangiogenic soluble
VEGF (
vascular endothelial growth factor )- receptor 1 (
soluble FMS - like tyrosine kinase 1 ) scavenges
VEGF and
PlGF (
placental growth factor ) , causing generalized
endothelial dysfunction . -
pubmed
In ex vivo adsorption experiments using serum samples from
patients with
preeclampsia ,
scVEGF multimers reduce
sFlt-1 levels by 85 % and increase
PlGF and
VEGF levels by 20- and 9 - fold , respectively . -
pubmed
We introduce the first
VEGF - based highly efficient
sFlt-1 apheresis system that is directly applicable in vivo due to utilization of inert agarose matrix , using a homomultimeric form of
VEGF165 to restore the angiogenic balance in
preeclampsia . -
pubmed
The critical role of the innate immune system has been confirmed in driving local and systemic inflammation and the
cytokine release storm in
severe acute respiratory syndrome coronavirus 2 (
SARS - CoV-2 ) . -
pubmed
This dysregulated immune response is focused on
interferon (
IFN ) and complement activation , which are crucial for the development of
metabolic inflammation , local
lung tissue damage , and
systemic multi - organ failure . -
pubmed
IFNs control
viral infections by inducing expression of IFN - stimulated genes ( ISGs ) that restrict distinct steps of viral replication . -
pubmed
Therefore , in this review article , we propose the mechanism of
SARS - CoV-2 - associated acute respiratory disease syndrome , and assess treatment options by considering
IFNs and by targeting
IFN - antagonist
SARS - CoV-2 virulent gene products . -
pubmed
Furthermore , we elaborate on the mechanism of the amplified complement - mediated inflammatory
cytokine storm , and propose an antiviral and immunotherapeutic strategy against
coronavirus disease 2019 ( COVID-19 ) . -
pubmed
Enzymatic Activity of
CD73 Modulates Invasion of
Gliomas via Epithelial - Mesenchymal Transition - Like Reprogramming . -
pubmed
Invasive growth of GSCs is in part associated with epithelial - mesenchymal - like transition ( EMT ) , a mechanism associated with
CD73 in several
cancers . -
pubmed
Here , we show that
CD73 regulates the EMT activator
SNAIL1 and further investigate the role of enzymatic and non - enzymatic
CD73 activity in
GBM progression . -
pubmed
Taken together , our data indicate that
CD73 is an exciting novel target in
GBM therapy . -
pubmed
The main outcome variables included the percentage of
necrotic area ( PNA ) in flap tissues , histopathological results ,
vascular endothelial growth factor (
VEGF ) immunohistochemical ( IHC ) staining , and
nitrite concentrations . -
pubmed
E - cadherin expression during the acidic
FGF - induced dispersion of a
rat bladder carcinoma cell line . -
pubmed
The effects of pretreatment with
atrial natriuretic factor (
ANF ) on the pressor responsiveness to injections of
angiotensin II (
ANGII ) ,
arginine vasopressin (
AVP ) , and
norepinephrine ( NE ) , as well as the effect of pretreatment with
ANGII on the
hypotensive responses to
ANF injection were studied in conscious
sheep . -
pubmed
In contrast , infusion of
AII had no effect on the immediate
hypotensive response to
ANF injection . -
pubmed
CYP21B gene conversion and complete
CYP21A gene deletion in
congenital adrenal hyperplasia . -
pubmed
Two main types of
CGD are known , an X - linked form which is normally associated with the absence of
cytochrome b558 , a component of the
membrane - associated reduced nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase which generates
superoxide and an autosomal recessive form , in which
cytochrome b558 is present , caused by the deficiency of a cytosolic factor required to activate
NADPH oxidase . -
pubmed
Autoantibodies directed at the
platelet membrane glycoprotein Ib (
GPIb ) can mediate a severe form of
idiopathic thrombocytopenic purpura (
ITP ) . -
pubmed
The DMId idiotype has been found in the plasma of several
patients with
ITP , usually in association with
GPIb - specific autoantibodies . -
pubmed
Recently ,
alpha recombinant interferon has been proposed as treatment for low grade
NHL . -
pubmed
The degree of abnormal immune function , as shown by abnormalities in
immunoglobulin levels , immune complex activity and T - lymphocyte subsets , was correlated with the extent of
lymphadenopathy . -
pubmed
A similar pattern of
immunologic abnormality was associated with seropositivity for
HTLV - III antibody . -
pubmed
Macular oedema frequently produces central
vision loss and legal
blindness , most commonly in non -
insulin dependent
diabetics . -
pubmed
Other therapeutic modalities , such as hypophysectomy for severe
retinopathy , remain controversial , while still others , such as rigorous blood
glucose control and
aldose reductase inhibitors , are currently under investigation . -
pubmed
Serum
tri - iodothyronine ( T3 ) ,
thyroxine ( T4 ) and
thyroid - stimulating hormone (
TSH ) concentrations were measured in 50 postmenopausal
patients with
breast cancer receiving
tamoxifen therapy . -
pubmed
Estrogen and
progesterone receptor content in
breast tumor cytosols calculated with a pocket calculator . -
pubmed
Streptozotocin diabetes also caused a decrease in the cross - linking of reparative
collagen as judged by the ratio of breaking strengths of skin incisions before and after
formalin fixation . -
pubmed
Based upon experimental data and theoretical considerations we conclude Sz
diabetes causes two defects in
wound healing : a ) quantitatively ( reduction in reparative
collagen accumulation ) and b ) qualitative reduction in the degree of cross - linking of reparative
wound collagen . -
pubmed
HLA - A , -B , and -DR associations in
type I diabetes mellitus with onset after age forty . -
pubmed
It remains to be convincingly demonstrated whether
insulin - requiring ,
ketosis - prone , lean - at - onset ,
type I diabetics who develop their disease after age 40 have the same disease as the children with similar characteristics . -
pubmed
One hundred forty white ,
insulin - using
diabetics with onset of disease past age 40 yr and 268 normal white controls have thus far been analyzed for
HLA type . -
pubmed
In the group of patients who were lean - at - onset and/or
ketosis - prone ( N = 54 ) , there was a significantly increased frequency of
DR4 ( RR = 4.63 ; P less than 0.01 ) and significantly decreased frequency of DR2 ( RR = 0.18 ; P less than 0.05 ) after correction . -
pubmed
DR4 was also significantly increased after correction ( RR = 5.72 ; P less than 0.25 ) in the subgroup who were both lean and
ketosis - prone ( N = 23 ) . -
pubmed
To our knowledge , this is the first such study in the United States , and the first demonstrating that late onset
diabetics who are lean - at - onset and/or
ketosis - prone exhibit
HLA - DR antigen associations which are similar to early onset cases . -
pubmed
Allogeneic bone marrow transplantation ( BMT ) involves
cytokines not only in their capacity as
hematopoietins but also as inducers of systemic inflammation after conditioning for BMT and during
graft - versus - host disease (
GVHD ) . -
pubmed
GVHD is , in fact , a paradigm disease of systemic
cytokine dysregulation , and the onset of severe acute
GVHD can be considered a "
cytokine storm . " -
pubmed
Advances in our understanding of the
cytokine networks involved in
BMT and
GVHD should increase our ability to modify the complex interactions among
cytokines and their cellular targets that lead to transplant - related morbidity . -
pubmed
Out of 318 women studied , 104 ( 32.7 % ) were
anaemic (
Hb levels & lt ; 10gm / dl ) . -
pubmed
Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a
microsomal triglyceride transfer protein . -
pubmed
Biochemical and genetic studies show that
abetalipoproteinemia is not a defect of lipid biosynthesis or of the
apolipoprotein B gene . -
pubmed
The
angiotensinogen (
AGT ) locus on chromosome 1q4 has been related to
hypertension in sibship linkage studies , association studies , and studies of
angiotensinogen levels by genotype in three different populations ( Utah , France , Japan ) . -
pubmed
Effect of
hypoxia on
insulin secretion by isolated
rat and
canine islets of Langerhans . -
pubmed
Second - phase
insulin secretion was reduced substantially by
hypoxia . -
pubmed
Perinatal hypothyroidism induced by
methimazole treatment did not significantly alter the appearance of cerebral cortical
G alpha o1 and
G alpha o2 between days 1 and 22 postpartum . -
pubmed
Improved perfusion with
rt - PA and hirulog in a
rabbit model of
embolic stroke . -
pubmed
We conducted a study using diffusion - weighted ( DWI ) and perfusion - weighted ( PWI ) magnetic resonance imaging ( MRI ) to evaluate the efficacy of thrombolysis in an
embolic stroke model with recombinant
tissue plasminogen activator (
rt - PA ) and hirulog , a novel direct - acting
antithrombin . -
pubmed
Significant
cerebral hemorrhage was observed in one placebo , two
rt - PA , and three
rt - PA plus
hirulog treated animals . -
pubmed
One fatal systemic
hemorrhage was observed in each of the
rt - PA groups . -
pubmed
We conclude that
rt - PA plus
hirulog improves cerebral perfusion but does not necessarily reduce
cerebral injury . -
pubmed
All had node positive
breast cancer and randomization was stratified by
estrogen receptor (
ER ) status . -
pubmed
This phenomenon was seen predominantly for high risk
breast cancer with low levels or no
estrogen receptors in the primary
tumor . -
pubmed
High resolution crystal structure of a
human tumor necrosis factor - alpha mutant with low
systemic toxicity . -
pubmed
A
human tumor necrosis factor - alpha (
TNF - alpha ) mutant ( M3S ) with low
systemic toxicity in vivo was designed , and its structures in two different crystal packings were determined crystallographically at 1.8 and 2.15 - A resolution , respectively , to explain altered biological activities of the mutant . -
pubmed
Compared with wild - type
TNF - alpha , it exhibits 11- and 71 - fold lower binding affinities for the
human TNF - R55 and
TNF - R75 receptors , respectively , and in vitro
cytotoxic effect and in vivo
systemic toxicity of M3S are 20 and 10 times lower , respectively . -
pubmed
However , in a transplanted solid tumor
mouse model , M3S suppresses
tumor growth more efficiently than wild - type
TNF - alpha . -
pubmed
The low systemic
toxicity of
M3S appears to be the effect of the reduced and selective binding affinities for the
TNF receptors , and the superior tumor - suppression of M3S appears to be the effect of its weak but longer antitumoral activity in vivo compared with wild - type
TNF - alpha . -
pubmed
Mutational inactivation of
aminoacylase - I in a
small cell lung cancer cell line . -
pubmed
Although nonmutational mechanisms for low or undetectable
ACYl enzymatic activity , protein , and mRNA expression are most frequently operant in
SCLC , the demonstration of a mutation supports selection for ACYl inactivation . -
pubmed
Serum anti -
beta2 - glycoprotein I antibodies from
patients with
antiphospholipid antibody syndrome bind central nervous system cells . -
pubmed
Sera from 20
patients with
antiphospholipid syndrome (
APS ) , primary or secondary to
systemic lupus erythematosus (
SLE ) , or with
SLE , were assayed by immunoblot analysis for anti -
beta2 - glycoprotein I antibodies (
abeta2 - GPI ) , and by indirect immunofluorescence ( IIF ) technique for reactivity with
astrocyte and neuron cell lines and with histological sections of
human brain biopsies and
monkey cerebellum . -
pubmed
This issue may be relevant to further evaluate the potential pathogenetic role of
abeta2 - GPI in the
CNS damage of
APS - like conditions . -
pubmed
Intestinal
reperfusion injury is mediated by
IgM and complement . -
pubmed
This study examines the role of the alternative and classic pathways of complement and
IgM in a
murine model of intestinal
ischemia - reperfusion . -
pubmed
Wild - type
animals ,
mice deficient in
complement factor 4 (
C4 ) ,
C3 , or Ig , or wild - type
mice treated with soluble
complement receptor 1 were subjected to 40 min of jejunal
ischemia and 3 h of reperfusion . -
pubmed
Compared with wild types , knockout and treated
mice had significantly reduced
intestinal injury , indicated by lowered permeability to radiolabeled
albumin . -
pubmed
We conclude that intestinal
ischemia -
reperfusion injury is dependent on the classic complement pathway and
IgM. -
pubmed
L - deprenyl inhibits
tumor growth , reduces
serum prolactin , and suppresses brain
monoamine metabolism in
rats with carcinogen - induced
mammary tumors . -
pubmed
The objective of the present study was to investigate the effects of
L - deprenyl , a
monoamine oxidase - B (
MAO - B ) inhibitor , treatment on the development and growth of
tumors and on the metabolism of
catecholamines and
indoleamine in the medial basal hypothalamus ( MBH ) and the striatum ( ST ) of
rats bearing
7,12 - dimethylbenzanthracene (
DMBA)-induced
mammary tumors . -
pubmed
Treatment with 5.0 mg
deprenyl decreased the
tumor diameter ,
tumor number , and
serum prolactin (
PRL ) level . -
pubmed
These results suggest that the suppression of the development and growth of
DMBA - induced
mammary tumors by chronic
deprenyl treatment may be mediated through alterations in the synthesis and metabolism of
catecholamines and
indoleamine in the MBH and inhibition of
PRL secretion . -
pubmed
Of the 243
CAD patients , 179 ( 74 % ) were positive by an ELISA method for
Chlamydia pneumoniae antibodies
IgG and 132 ( 54 % ) were positive for
C. - pubmed
When
IgG antibodies were considered , there was no significant difference between
CAD patients and healthy controls ( OR = 1.29 , 95 % CI = 0.79 - 2.10 , p & gt ; 0.05 ) . -
pubmed
In cases of positive
IgA antibodies alone , there was a significant difference between
CAD patients and healthy controls ( OR = 1.58 , 95 % CI = 1.01 - 2.4 , p = 0.029 ) . -
pubmed
Synthesis and secretion of
MCP-1 by dental follicle cells -- implications for
tooth eruption . -
pubmed
BACKGROUND : Mutations of the
RET proto - oncogene co - segregate with
multiple endocrine neoplasia type 2A. -
pubmed
Interleukin-13 gene therapy reduces
inflammation , vascularization , and bony destruction in
rat adjuvant - induced
arthritis . -
pubmed
Adenoviral production of
interleukin-13 (
IL-13 ) reduces levels of proinflammatory mediators in an explant model of
RA synovial tissue in vitro . -
pubmed
To assess this approach in an animal model of
arthritis , we compared intra - articular injections of an
adenovirus producing
rat IL-13 (
AxCArIL-13 ) , a control virus , and
rat ankles receiving
phosphate - buffered saline ( PBS ) in
rat adjuvant - induced
arthritis (
AIA ) . -
pubmed
We demonstrate that
IL-13 levels are normally low in ankles throughout the course of
rat AIA . -
pubmed
We show that administration of
AxCArIL-13 before
arthritis onset significantly reduces ankle circumference , paw volume , bony destruction , the number of polymorphonuclear cells ( PMNs ) , the quantity of blood vessels , and levels of
monocyte chemoattractant protein ( MCP )- 1 in ankles . -
pubmed
When administered as a treatment to inflamed ankles ,
AxCArIL-13 decreases articular index scores , paw volumes ,
bony destruction , vascularization ,
tumor necrosis factor - alpha (
TNF - alpha ) levels , and the quantity of monocytes , lymphocytes , and PMNs . -
pubmed
Thus , increasing
IL-13 levels significantly ameliorates the course of
rat AIA , suggesting that similar strategies for the treatment of
human RA are worthy of further study . -
pubmed
By using a comprehensive panel of
monoclonal antibodies we identified at least one
leukemia - associated aberrant immunophenotype ( LAIP ) in each patient . -
pubmed
Six isolates of an unknown Gram - positive ,
catalase - negative , chain - forming , coccus - shaped organism isolated from ovine and caprine
mastitis were characterized by phenotypic and molecular taxonomic methods . -
pubmed
Inflammation and extracellular matrix degradation mediated by activated
transcription factors nuclear factor - kappaB and
activator protein-1 in inflammatory
acne lesions in vivo . -
pubmed
We report here that
transcription factors nuclear factor - kappaB and
activator protein-1 are activated in
acne lesions with consequent elevated expression of their target gene products , inflammatory
cytokines and
matrix - degrading metalloproteinases , respectively . -
pubmed
These elevated gene products are molecular mediators of
inflammation and
collagen degradation in
acne lesions in vivo . -
pubmed
[ Correlation between platelet count and
CA-125 in
ovarian cancer ] . -
pubmed
In the
thrombocytosis group , an average
CA-125 level ( 913.5 U / ml ) was significantly higher ( p & lt ; 0.00001 ) then in the group with normal platelet count ( 103.7 U / ml ) . -
pubmed
CONCLUSIONS : Platelet count and
CA-125 levels do correlate in blood samples taken from
ovarian cancer patients at the same time . -
pubmed
Antiangiogenic treatment with three
thrombospondin-1 type 1 repeats versus
gemcitabine in an orthotopic
human pancreatic cancer model . -
pubmed
PURPOSE : In this study , we investigated the antitumor efficacy of
thrombospondin-1 three type 1 repeats ( 3TSR ) , the antiangiogenic domain of
thrombospondin-1 , in comparison and in combination with
gemcitabine , in an orthotopic
pancreatic cancer model . -
pubmed
Extensive
necrotic areas were observed in
tumors from
3TSR - treated
mice , whereas
tumors from
gemcitabine and combinatorially treated
mice were less
necrotic than control
tumors . -
pubmed
CONCLUSION :
3TSR , the antiangiogenic domain of
thrombospondin-1 , showed comparable antitumor efficacy to
gemcitabine in a
human pancreatic cancer orthotopic
mouse model . -
pubmed
We evaluated whether or not the elevated levels
beta2 - microglobulin in
CSF can be a useful marker for diagnosis of
lymphoproliferative disorders in 108
patients with
neurological diseases . -
pubmed
A
CSF to serum
beta2 - microglobulin ratio greater than 1 was closely associated with intrathecal synthesis
beta2 - microglobulin in
CNS lymphoproliferative disorders . -
pubmed
Elevation of
CSF beta2 - microglobulin ratio is a sensitive marker of central nervous system disease activity by infiltrating lymphocytes in
intracranial lymphomas ( 10/10 ) and
paraneoplastic neurological syndromes ( 2/3 ) . -
pubmed
HLA - B27 - associated acute
anterior uveitis in the University Referral Centre in North Thailand : clinical presentation and visual prognosis . -
pubmed
Although
human leucocyte antigen ( HLA )- B27 - associated
ankylosing spondylitis was reported in South East Asia , it is not known whether
HLA - B27 - associated ocular disease is prevalent in Thailand . -
pubmed
The clinical characteristics of
HLA - B27 - associated
AAU were similar to those published throughout the world ( unilaterality in 74 % ,
hypopyon in 31 % , recurrent
AAU in 64 % ) . -
pubmed
At least 15 % of the
HLA B27 - positive group had radiological signs of
ankylosing spondylitis . -
pubmed
CONCLUSION : The prevalence of
HLA - B27 in the population without
uveitis in Thailand is about 10 % and clinical characteristics of
HLA - B27 - positive
AAU are similar to those reported in the west . -
pubmed
In contrast with earlier reports ,
HLA - B27 - negative
AAU in Thailand was associated with increased IOP and should be further studied . -
pubmed
[
Hepatocellular carcinoma occurring after 11 year - long sustained viral response to
interferon therapy for
chronic hepatitis C ] . -
pubmed
OBJECTIVE : To construct
anti - CD20scFv / CD80 / CD28 / zeta recombinant gene modified T cells , test its effectiveness of eradicating
CD20 +
lymphoma cells and provide a probably new approach to
tumor adoptive immunotherapy . -
pubmed
The
cytotoxicity and
cytokine production of
transduced T cells were determined by non - radio - activation
cytotoxicity assay and ELISA respectively . -
pubmed
It can specially kill
CD20 positive
lymphoma cells in vitro . -
pubmed
Pompe disease , which results from mutations in the gene encoding the
glycogen - degrading lysosomal enzyme acid alpha - glucosidase (
GAA ) ( also called "
acid maltase " ) , causes death in early childhood related to glycogen accumulation in striated muscle and an accompanying infantile - onset
cardiomyopathy . -
pubmed
The efficacy of enzyme replacement therapy ( ERT ) with recombinant
human GAA was demonstrated during clinical trials that prolonged
subjects ' overall survival , prolonged ventilator - free survival , and also improved
cardiomyopathy , which led to broad - label approval by the U.S. Food and Drug Administration . -
pubmed
About 30 - 40 % of
patients with insect
venom allergy have
IgE antibodies reacting with both
honeybee and Vespula venom . -
pubmed
This study should stimulate further research to determine the implication of altered
IP in the disease pathophysiology of
FM and
CRPS . -
pubmed
Earlier studies identified the
dynorphin - kappa opioid receptor (
KOR ) system as a critical mediator of
dysphoria - induced aversion after repeated stress exposure , but the molecular signaling mechanisms were not fully characterized . -
pubmed
At the beginning and at the end of the study we recorded some clinical indicators such as BMI and WHR , some hormonal indicators such as
testosterone ,
insulin ,
SHBG and
DHEAS , as well as some metabolic indicators such as total
cholesterol ,
triglycerides and
HDL - C. RESULTS : We discovered a considerable reduction of 27,1 % in
insulin and HOMA - IR ( 29,1 % ) , which indicates an improved
insulin resistance . -
pubmed
Gasdermin (
GSDM or
GSDMA ) , expressed in the upper gastrointestinal tract but frequently silenced in
gastric cancers ( GCs ) , regulates apoptosis of the gastric epithelium . -
pubmed
Colony formation assay showed that
GSDMB , closely related to
GSDMA , has no cell - growth inhibition activity in
gastric cancer cells , and that
GSDMC and
GSDMD , respectively , exhibit the activity with different strengths from that of
GSDMA . -
pubmed
In this study , we extend these results to describe the use of a humanized , high - expression , hybrid
human /
porcine fVIII transgene that is 89 % identical to
human fVIII and was delivered by
lentiviral vectors ( LVs ) to hematopoietic stem cells for gene therapy of
hemophilia A. -
pubmed
From these studies , we conclude that humanized high - expression hybrid
fVIII transgenes can be utilized in gene therapy applications for
hemophilia A to significantly increase
fVIII expression levels compared to what has been previously achieved . -
pubmed
Loss of endogenous
interleukin-12 activates survival signals in ultraviolet - exposed
mouse skin and
skin tumors . -
pubmed
UV - induced
skin tumors of
IL-12 KO
mice had higher levels of
PI3 K , p -
Akt (
Ser(473 ) ) , p -
ERK1 / 2 , p -
p38 ,
NF - kappaB , and
PCNA and fewer apoptotic cells than
skin tumors of wild types . -
pubmed
Dietary - induced
hyperparathyroidism affects serum and gingival proinflammatory
cytokine levels in
rats . -
pubmed
This study investigated the systemic and periodontal effects of dietary - induced
hyperparathyroidism (
dHPT ) by evaluating serum and gingival proinflammatory
cytokine levels . -
pubmed
Serum
cytokines were analyzed in the blood samples collected prior to
periodontitis induction , whereas gingival
cytokines were analyzed in the gingival supernatants of the four groups . -
pubmed
CONCLUSION : The results suggested that increased serum proinflammatory
cytokine production may be a complication of dHPT , and this may affect healthy and diseased
periodontia by increasing gingival proinflammatory
cytokine levels . -
pubmed
More than 700 mutations have been described in 12 genes (
LQT1 - LQT12 ) involved in
congenital long QT syndrome . -
pubmed
In the case of a suspicious clinical presentation ( firm mass ,
nipple retraction ) and/or the presence of risk factors for
breast cancer (
BRCA2 mutation , previous
breast cancer ) , core needle biopsy always demonstrated malignancy . -
pubmed
Chitin hydrolysate stimulates
VEGF - C synthesis by
MDA - MB-231 breast cancer cells . -
pubmed
Up - regulation of
VEGF - C (
vascular endothelial growth factor C ) , a most potent lymphangiogenic factor , is associated with
inflammation and
cancer metastasis . -
pubmed
Hypersensitivity to
thromboxane receptor mediated cerebral vasomotion and CBF oscillations during acute
NO - deficiency in
rats . -
pubmed
CONCLUSION / SIGNIFICANCE : These results suggest that
hypersensitivity of the
TP - receptor -
Rho - kinase signaling pathway contributes to the development of low frequency cerebral vasomotion which may propagate to
vasospasm in pathophysiological states associated with
NO - deficiency . -
pubmed
Interleukin-30 : a novel antiinflammatory
cytokine candidate for prevention and treatment of inflammatory cytokine - induced
liver injury . -
pubmed
Here we establish the role of
IL30 as a potent antiinflammatory
cytokine that can inhibit inflammation - induced
liver injury . -
pubmed
In animal models , administration of
IL30 by way of a gene therapy approach prevents and treats both
IL12- ,
IFN - gamma- , and concanavalin A - induced
liver toxicity . -
pubmed
Likewise , immunohistochemistry analysis of
human tissue samples revealed that
IL30 is highly expressed in hepatocytes , yet barely expressed in
inflammation - induced tissue such as fibrous / connective tissue . -
pubmed
CONCLUSION : These novel observations reveal a novel role of
IL30 as a therapeutic
cytokine that suppresses proinflammatory
cytokine - associated
liver toxicity . -
pubmed
DRDE / WH-02 showed better
wound healing as evidenced by widespread re - epithelialization , homogenous
fibroplasias well supported by the expression of
transforming growth factor - alpha ,
endothelial nitric oxide synthase (
eNOS ) and
fibroblast growth factor . -
pubmed
Upregulation of
interleukin 6 in DRDE / WH-02 - treated
mice skin resulted in increased tissue
leukocytosis and an early removal of tissue debris that initiated reparative process at faster rate compared to other groups . -
pubmed
This study demonstrated that these
MAbs could recognize CCV specifically and will be useful in the development of diagnostic methods for the detection of fish
CCV infection . -
pubmed
Early and extensive
CD55 loss from red blood cells supports a causal role in
malarial anaemia . -
pubmed
BACKGROUND : Levels of
complement regulatory proteins (
CrP ) on the surface of red blood cells ( RBC ) decrease during severe
malarial anaemia and as part of cell ageing process . -
pubmed
It remains unclear whether
CrP changes seen during
malaria contribute to the development of
anaemia , or result from an altered RBC age distribution due to suppressive effects of
malaria on erythropoiesis . -
pubmed
METHODS : A cross sectional study was conducted in the north - east coast of Tanzania to investigate whether the changes in
glycosylphosphatidylinositol ( GPI)-anchored
complement regulatory proteins (
CD55 and
CD59 ) contributes to
malaria anaemia . -
pubmed
Levels of
CD59 were lower in
anaemic children , but these differences were not significant . -
pubmed
CD55 , but not
CD59 , levels correlated positively with the level of
haemoglobin in
anaemic children . -
pubmed
CONCLUSION : The extent of
CD55 loss from RBC of all ages early in the course of
malarial anaemia and the correlation of
CD55 with
haemoglobin levels support the hypothesis that
CD55 may play a causal role in this disorder . -
pubmed
Pathologic assessment included volume of excision , subtype , size , distance from margin , grade ,
necrosis , multifocality ,
calcifications , and
ER /
PR status . -
pubmed
AIMS : To examine the frequency of
AGT and its outcome in prepubertal
CF patients and the changes in glycemic and nutritional status and lung function over the preceding year . -
pubmed
Among initial
AGT patients , of 4 INDET : 2 developed
IGT , 1
CFRD . -
pubmed
CONCLUSIONS : The high frequency of
AGT in prepubertal
CF patients and their negative clinical impact supports the usefulness of an earlier glycemic screening . -
pubmed
Spontaneous preterm delivery was found to be significantly associated with unmarried status ( cOR : 1.7;1.52 - 2.57 ) , baseline
CD4 count & lt;200 cells / mm(3 ) ( cOR : 1.8 ; 1.16 - 2.99 ) , presence of
opportunistic infection at delivery ( cOR : 2.2;1.23 - 3.57 ) , multiple pregnancy ( cOR 10.4 ; 4.24 - 26.17 ) , use of PI based triple ARV therapy ( eOR 10.2 ; 5.52 - 18.8 ) in the first trimester ( cOR 2.5 ; 1.77 - 3.52 ) on univariate analysis . -
pubmed
A clinical - biological risk stratification model for resected
gastric cancer : prognostic impact of
Her2 ,
Fhit , and
APC expression status . -
pubmed
PATIENTS AND METHODS : Clinicopathological and molecular data ( expression of
Cdx2 ,
Apc ,
beta - catenin ,
E - cadherin ,
Fhit ,
p53 , and
human epidermal growth factor receptor-2 (
Her2 ) ;
HER2 and
TOPO2A gene copy number ;
PIK3CA mutations ; microsatellite instability ) were correlated to
cancer - specific / overall survival ( CSS / OS ) using a Cox model . -
pubmed
At multivariate analysis , sex , stage , margins , location , nodes ,
Apc , and Fhit were independent predictors for
CSS ; the same factors ( and age and
Her2 , except
Fhit ) predicted OS . -
pubmed
CONCLUSIONS : A risk classification system comprising the immunohistochemical expression of three proteins (
Apc ,
Fhit , and
Her2 ) and five clinicopathological parameters ( stage , resected nodes , margins , location , and sex ) accurately separates the resected
gastric cancer patients into three classes of risk . -
pubmed
10 days after the start of using
spironolactone and
dabigatran bleeding was marked with decrease in
hemoglobin levels to 69 g / l ,
creatinine level increases to 3.6 mg / dL ( glomerular filtration rate by MDRD 18 ml / min/1,73 m2 ) , and
potassium to 5.5 mEq/ l. Against the background of the abolition of drugs normalization of renal function was marked . -
pubmed
A common mechanism is the overexpression of
ATP - binding cassette ( ABC ) efflux transporters in
cancer cells such as
P - glycoprotein (
P - gp /
ABCB1 ) ,
multidrug resistance - associated protein 1 (
MRP1 /
ABCC1 ) and
breast cancer resistance protein (
BCRP /
ABCG2 ) that limit the exposure to anticancer drugs . -
pubmed
In addition ,
ABC transporters such as
P - gp ,
MRP1 and
BCRP co - expressed in
tumors show a broad and overlapped specificity for substrates and
MDR modulators . -
pubmed
Predictors of
congestive heart failure after treatment with an
endothelin receptor antagonist . -
pubmed
BACKGROUND AND OBJECTIVES : The
Avosentan on Time to Doubling of Serum
Creatinine , End Stage
Renal Disease or Death ( ASCEND ) trial tested the renoprotective effect of the
endothelin receptor antagonist
avosentan in
patients with
diabetes and
nephropathy , but the study was terminated due to an excess of
congestive heart failure (
CHF ) events in the
avosentan arms , likely due to fluid retention . -
pubmed
Furthermore , postrandomization changes between baseline and the first available measurement of body weight and
hemoglobin were examined as potential clinical indicators of fluid retention for their relationship with
CHF development . -
pubmed
The body weight increase induced by
avosentan was associated with
CHF development ( P interaction=0.04 ) , whereas
hemoglobin decrease was not ( P interaction=0.64 ) . -
pubmed
CONCLUSIONS : In
avosentan - treated
patients , body weight increase , but not
hemoglobin decrease , was associated with
CHF development , indicating that close body weight monitoring could provide an early signal of
CHF development in future trials with
endothelin receptor antagonists . -
pubmed
Concurrently , CNTs did not induce any intrinsic abnormal immune response or
inflammation , as confirmed by normal
cytokine levels and histological evaluations . -
pubmed
BACKGROUND : Addition of
catechol - O - methyltransferase inhibitors to a conventional
levodopa /
dopadecarboxylase inhibitor regimen improves motor symptoms in
patients with
Parkinson ' s disease . -
pubmed
They often exhibit discrepancies with the primitive
tumor , especially concerning the molecular basis of sensitivity / resistance to targeted therapies ( expression of
HER2 and
hormone receptors , mutations responsible for resistance to
tyrosine - kinase inhibitors ) . -
pubmed
Intravitreal anti -
vascular endothelial growth factor for typical exudative age - related
macular degeneration in eyes with good baseline visual acuity . -
pubmed
PURPOSE : To investigate 12 - month treatment outcomes of anti -
vascular endothelial growth factor therapy in eyes with typical exudative age - related
macular degeneration with good baseline visual acuity . -
pubmed
Diagnostic Values of Cerebrospinal Fluid
T - Tau and
Abeta42 using Meso Scale Discovery Assays for
Alzheimer ' s Disease . -
pubmed
BACKGROUND : Meso Scale Discovery ( MSD ) recently established electrochemiluminescence - based assays to measure cerebrospinal fluid ( CSF ) levels of total
tau ( t - tau ) and
amyloid - beta 1 - 42 peptide (
Abeta42 ) that can aid in the diagnosis of
Alzheimer ' s disease (
AD ) . -
pubmed
The deletion of the gene
Hmox1 in
mice leads to inadequate remodeling of spiral arteries and suboptimal placentation followed by
intrauterine growth restriction (
IUGR ) and
fetal lethality . -
pubmed
A partial
Hmox1 deletion leads to
IUGR as well , with heterozygote and wild - type fetuses being born , but
Hmox1 ( -/- ) significantly below the expected Mendelian rate . -
pubmed
Similarly ,
HO-1 inhibition provokes
hypertension in pregnant
rats . -
pubmed
Merlin expression , encoded by the
NF2 gene , is lost in a majority of
meningiomas , and
merlin is a negative regulator of
mTORC1 . -
pubmed
The
sst2 somatostatin receptor , targeted by
octreotide , is highly expressed in
meningiomas . -
pubmed
Further ,
everolimus decreased cell viability of
human meningiomas , but concomitantly , induced
Akt activation , reducing the antiproliferative effect of the drug . -
pubmed
Multiparity and
insulin - treated
GDM were exclusion criteria . -
pubmed
CONCLUSION : It seems that aerobic training with
vitamin D , due to the involvement of muscle mass and exposure to dynamic pressure on the bones and muscles , increased energy expenditure , stimulated
insulin exudation and
glucose homeostasis , decreased
insulin resistance and improved the lipid profile in ovariectomized
rats . -
pubmed
CVD strains [ spontaneously
hypertensive (
SH ) , SH
stroke - prone ( SHSP ) , SHHF / Mcc
heart failure obese ( SHHF ) ,
insulin - resistant JCR : LA - cp obese ( JCR ) and Fawn - Hooded
hypertensive (
FHH ) ] were compared with normal strains [ Wistar , Sprague - Dawley ( SD ) and Wistar Kyoto ( WKY ) ] . -
pubmed
The children with
moyamoya syndrome presented with abnormal
CD4 counts and raised viral loads . -
pubmed
A novel
PPARalpha agonist
propane-2 - sulfonic acid octadec-9 - enyl - amide inhibits
inflammation in
THP-1 cells . -
pubmed
Because
PPARalpha activation is associated with
inflammation control , we hypothesize that N15 may have anti - inflammatory effects . -
pubmed
In particular , we assessed the production of
chemokines ,
adhesion molecules and proinflammatory
cytokines , three important types of
cytokines that are released from monocytes and are involved in the development of
atherosclerosis . -
pubmed
In Vivo FRET Imaging of
Tumor Endothelial Cells Highlights a Role of Low
PKA Activity in Vascular Hyperpermeability . -
pubmed
PKA activation with a
cAMP analogue alleviated the
tumor vascular hyperpermeability , suggesting that the low
PKA activity in the endothelial cells may be responsible for the tumor - tissue hyperpermeability . -
pubmed
Motesanib , a
kinase inhibitor for
VEGF receptor , activated
tumor endothelial
PKA and reduced the vascular permeability in the
tumor . -
pubmed
Notably , in cultured
human umbilical vascular endothelial cells ,
VEGF activated
PKA rather than decreasing its activity , highlighting the remarkable difference between its actions in vitro and in vivo These data suggested that the
VEGF receptor signaling pathway increases vascular permeability , at least in part , by reducing endothelial
PKA activity in the live
tumor tissue . -
pubmed
Breakage analysis revealed OS specific unstable regions in which well - known OS
tumor suppressor genes , including
TP53 ,
RB1 ,
WWOX ,
DLG2 and
LSAMP are located . -
pubmed
Docosanoids include
neuroprotectin D1 (
NPD1 ) , which is decreased in the CA1 hippocampal area of
patients with early - stage
Alzheimer ' s disease (
AD ) . -
pubmed
We summarize here how
NPD1 elicits neuroprotection by up - regulating
c - REL , a
nuclear factor ( NF )- kappaB subtype that , in turn , enhances expression of
BIRC3 (
baculoviral inhibitor of apoptosis repeat - containing protein 3 ) in the retina and in experimental
stroke , leading to neuroprotection . -
pubmed
Disease - causing variants were identified in
MYO6 ,
CLN6 ,
LRBA ,
KCTD7 , and
ARSB revealing a genetic diagnosis of a
LD in 8 individuals from 5 families . -
pubmed
MiR-146a-5p correlates with clinical efficacy in
patients with
psoriasis treated with the
tumour necrosis factor - alpha inhibitor adalimumab . -
pubmed
However , the role of
GIP in
peripheral artery disease remains unclear . -
pubmed
The genetic deletion of
GIP receptor (
GIPR ) led to exaggerated
neointimal hyperplasia after transluminal femoral artery wire injury . -
pubmed
Conversely , chronic
GIP infusion suppressed
neointimal hyperplasia and facilitated endothelial regeneration . -
pubmed
Our findings imply the potential vascular benefits of multiple agonists targeting G protein - coupled receptors , including
GIPR , which are under development for the treatment of
type 2 diabetes . -
pubmed
Detection of
PrPres in peripheral tissue in
pigs with clinical disease induced by intracerebral challenge with
sheep - passaged
bovine spongiform encephalopathy agent . -
pubmed
H3K4me3 and
Wdr82 are associated with
tumor progression and a favorable prognosis in human
colorectal cancer . -
pubmed
Histone H3 trimethylation at
lysine 4 ( H3K4me3 ) has been reported to modulate the expression of tumor - associated expression and be altered during the progression of several
human cancers . -
pubmed
An aim of the present study was to determine H3K4me3 and
Wdr82 expression and their clinical significances in
colorectal cancer (
CRC ) . -
pubmed
Immunohistochemistry results demonstrated that the expression level of the H3K4me3 and
Wdr82 were significantly decreased in
CRC tissues compared with paired
noncancerous tissues from 123 patients with
CRC . -
pubmed
Additionally , multivariate Cox regression analysis indicated that the low expression level of H3K4me3 or
Wdr82 was associated with reduced overall survival ( OS , P<0.05 ) , and patients with a low H3K4me3 and
Wdr82 expression had a significantly poorer outcome compared with patients with a high expression of H3K4me3 and
Wdr82 ( P=0.0001 ) , suggesting that H3K4me3 and
Wdr82 expression were independent factors for OS in patients with
CRC . -
pubmed
In conclusion , the decreased expressions of H3K4me3 and
Wdr82 were associated with a poor prognosis in
CRC . -
pubmed
The combined expression of H3K4me3 and
Wdr82 may serve as a novel prognostic marker for
CRC . -
pubmed
The main factor of
ascites formation is renal
sodium retention due to activation of the
renin -
angiotensin -
aldosterone system and sympathetic nervous system by the reduced effective volume secondary to splanchnic arterial vasodilation . -
pubmed
A
serum - ascites albumin gradient of & gt;=1.1 g / dL indicates
portal hypertension with an accuracy of approximately 97 % . -
pubmed
Repeated large volume paracentesis plus
albumin is the first line treatment , and liver transplantation is recommended in
patients with refractory
ascites . -
pubmed
The high distribution of
CB2 receptors in immune cells suggests their important role in the control of
inflammation . -
pubmed
Growing evidence offers this receptor as an attractive therapeutic target : selective
CB2 agonists are able to modulate
inflammation without triggering psychotropic effects . -
pubmed
Bronchial epithelial cells produce
CXCL1 in response to LPS and
TNFalpha : A potential role in the pathogenesis of
COPD . -
pubmed
CXC chemokine ligand ( CXCL ) 1 is a
neutrophil chemokine involved in the pathogenesis of
COPD . -
pubmed
MATERIALS AND METHODS : We measured sputum
CXCL1 and
CXCL8 levels in
patients with
COPD ,
asthma , and
asthma -
COPD overlap ( ACO ) , and compared them to those of
patients with
interstitial pneumonia (
IP ) . -
pubmed
RESULTS : Sputum
CXCL1 levels in
COPD and
ACO patients were higher than in IP
patients , whereas sputum
CXCL8 levels were not . -
pubmed
CONCLUSIONS : Sputum
CXCL1 levels is a potentially better diagnostic marker for
COPD than sputum
CXCL8 levels , which is explained by that
CXCL1 production in bronchial epithelial cells is less affected by therapeutic anti - inflammatory agents than
CXCL8 production . -
pubmed
PATZ1 is required for efficient
HIV-1 infection . -
pubmed
Here , expression cloning with a cDNA expression library identified as an inhibitor of
HIV-1 infection , a
carboxy - terminally truncated form of
human POZ / BTB and
AT - hook - containing Zinc finger protein 1 (
PATZ1 ) , a transcriptional regulatory factor implicated in development and
cancer . -
pubmed
Knockdown or knockout of endogenous
PATZ1 revealed a supportive role of
PATZ1 in
HIV-1 infection , but not in transduction with
murine leukemia virus - based
retroviral vector . -
pubmed
More specifically , knockdown or knockout of
PATZ1 impaired the viral cDNA synthesis but not the entry process and expression of two
PATZ1 isoforms in
PATZ1 - KO cells restored susceptibility to
HIV-1 infection . -
pubmed
These results indicate that
PATZ1 plays an important role in
HIV-1 infection . -
pubmed
MATERIALS AND METHODS : In vivo HLJDT effects were investigated by determining the severity of
dermatitis , which consisted of observing signs of
skin lesions , visually and through
haematoxylin and
eosin ( HE ) staining , in
mouse ears and dorsal skin , measuring serum levels of
interleukin ( IL )- 1alpha ,
IL-1beta ,
IL-2 ,
IL-4 ,
IL-5 ,
IL-6 ,
interferon ( IFN )- gamma , the
tumour necrosis factor ( TNF )- alpha , and determining the splenic index , number of splenic
CD4+/
CD8 + T - lymphocytes , as well as the phosphorylation levels of
mitogen - activated protein kinases ( including
MAPKs -
p38 ,
ERK , and
JNK ) ,
IkappaB - alpha , and
nuclear factor kappa B (
NF - kappaB ) (
p65 ) within
dermal lesions . -
pubmed
Morphological changes in LPS - induced
inflammation were observed under a microscope , and ELISA and qPCR assays were used to measure
IL-1alpha ,
IL-1beta ,
IL-6 , and
TNF - alpha expression levels . -
pubmed
RESULTS : HLJDT could remarkably mitigate
DNCB - induced
AD - like lesion symptoms , alleviating inflammatory mediator infiltration in
mouse ears and dorsal skin tissue , down - regulating serum expression levels of
IL-1alpha ,
IL-1beta ,
IL-2 ,
IL-4 ,
IL-5 ,
IL-6 ,
IFN - gamma , and
TNF - alpha , normalising the splenic
CD4+/
CD8 + T - lymphocyte ratio , and inactivating
MAPKs ( including
p38 ,
ERK , and
JNK ) ,
IkappaB - alpha , and
NF - kappaB (
p65 ) in dorsal skin . -
pubmed
CONCLUSIONS : HLJDT significantly improved
AD - like symptoms via inhibition of the
MAPKs /
NF - kappaB pathway . -
pubmed
PURPOSE : To investigate the differences in protein expression between
Dpy19l2 - deficient
human globozoospermia and
normozoospermia . -
pubmed
EXPERIMENTAL DESIGN :
Human sperm samples from three
globozoospermic donors with
Dpy19l2 deletion and three normal controls are subjected to TMT quantitative technology . -
pubmed
The levels of several important proteins , including
SPACA 1 ,
IZUMO1 ,
ZPBP1 , and
PLCZ1 , are decreased in
globozoospermic sperm . -
pubmed
CONCLUSIONS AND CLINICAL RELEVANCE : The present study is the first to analyze total
globozoospermia with
Dpy19l2 deletion using high - throughput proteomics . -
pubmed
RESULTS : In the training cohort ,
hepatocellular carcinoma (
HCC ) ,
diabetes , total
bilirubin (
TBIL ) ,
albumin (
ALB ) ,
alanine aminotransferase (
ALT ) , and serum
creatinine ( Scr ) were independent predictors of in - hospital death . -
pubmed
SG - SP1 Suppresses Mast Cell - Mediated
Allergic Inflammation via Inhibition of
FcepsilonRI Signaling . -
pubmed
To improve on preliminary evidence that GA has
allergy mitigating effect , we designed
SG - SP1 based on GA , and aimed to assess the effects of
SG - SP1 on mast cell - mediated
allergic inflammation using various
animal and in vitro models . -
pubmed
Immunoglobulin ( Ig ) E - induced passive cutaneous
anaphylaxis and
ovalbumin - induced systemic
anaphylaxis , standard
animal models for immediate - type
hypersensitivity were also used . -
pubmed
Oral administration of
SG - SP1 hindered allergic symptoms of both
anaphylaxis models evidenced by reduction of
hypothermia , serum
IgE , ear thickness , and tissue pigmentation . -
pubmed
Conclusions : We determined that
SG - SP1 directly interacts with
FcepsilonRI and propose
SG - SP1 as a therapeutic candidate for mast cell - mediated
allergic inflammatory disorders via inhibition of
FcepsilonRI signaling . -
pubmed
In all
patients with
thyrotoxicosis , multiple linear regression analyses showed free
thyroxine ( FT(4 ) ) ( beta=0.371 , 95%CI 0.005 - 0.010 , P<0.001 ) and
TRAb ( beta=0.138 , 95%CI 0.001 - 0.014 , P=0.035 ) were positively associated with STA - PSV . -
pubmed
Conclusions : The STA - PSV is positively associated with FT(4 ) and
TRAb levels , and it is a helpful marker in differential diagnosis between
GD and
AIT . -
pubmed
Metastasis of
Uveal Melanoma with
Monosomy-3 Is Associated with a Less Glycogenetic Gene Expression Profile and the Dysregulation of Glycogen Storage . -
pubmed
UMs with monosomy-3 exhibited a less glycogenetic and more
insulin - resistant gene expression profile , together with the reduction of glycogen levels , which were associated with the metastases . -
pubmed
Expression of
glycogenin-1 ( Locus : 3q24 ) was lower in the monosomy-3
tumors , whereas the complementary isoform
glycogenin-2 ( Locus : Xp22.33 ) was upregulated in females . -
pubmed
MicroRNA-130a-3p promotes the proliferation and inhibits the apoptosis of
cervical cancer cells via negative regulation of
RUNX3 . -
pubmed
In conclusion , miR-130a-3p promoted proliferation , migration and invasion , and inhibited the apoptosis of
CC cells via targeting
RUNX3 , suggesting a novel treatment target for
CC . -
pubmed
RESULTS : Independently of their localization in different anatomic niches , macrophages in
mice with transplanted
Ehrlich carcinoma gradually lose their tumoricidal activities while
arginase activity is upregulated . -
pubmed
Stress - induced premature senescence activated by the
SENEX gene mediates apoptosis resistance of
diffuse large B - cell lymphoma via promoting immunosuppressive cells and
cytokines . -
pubmed
RESULTS : The proportion of senescent
lymphoma cells was significantly increased in r / r
DLBCL patients , concomitant with increased Treg , MDSC , and various secreted
cytokines with proinflammatory and immunosuppressive effects . -
pubmed
The
SENEX gene was significantly elevated in the
SIPS model . -
pubmed
Senescent
DLBCL cells had good antiapoptotic ability and proliferative activity accompanied by increased immunosuppressive
cytokines . -
pubmed
CONCLUSION : SIPS activated by the
SENEX gene mediates apoptosis resistance of r / r
DLBCL via promoting immunosuppressive cells and
cytokines . -
pubmed
Cryptorchidism and
gonadotrophin therapy . -
pubmed
[ Assessment of the B - cell function in
diabetic patients by means of the determination of
insulin secretion following
glucose -
tolbutamide stimulation ] . -
pubmed
In this study , the
thyroxine ( T4 ) and
triiodothyronine ( T3 ) serum concentrations , and
thyrotropin (
TSH ) response to intravenous administration of
thyrotropin releasing hormone (
TRH ) were determined in 6
patients ( aged 9 to 15 yr ) with
anorexia nervosa and the results compared to those found in a group of 15 normal
subjects . -
pubmed
Doses of
rMuIFN - gamma that had no effect on
papilloma multiplicities when administered 1 day prior to
TPA treatment increased the numbers of
papillomas per
mouse by 33 - 38 % when administered immediately prior ( zero time ) to
TPA application . -
pubmed
Carcinoma incidence and multiplicities by weeks 46 - 48 of the promotion - progression period were statistically indistinguishable for initiated
mice treated with
TPA ,
TPA +
DFMO ,
TPA +
IFN - gamma or
TPA +
DFMO +
IFN - gamma . -
pubmed
administration of
rMuIFN - gamma to papilloma - bearing
mice in a
tumor progression study , with and without simultaneous topical
TPA treatment , did not affect
carcinoma latency or
carcinoma multiplicities . -
pubmed
administration of
rMuIFN - gamma to C57BL/6
mice at the time of
TPA treatment , at doses that were co - promoting in
SENCAR mice , did not increase
papilloma multiplicities . -
pubmed
UNLABELLED : The aim of the study was to investigate the prevalence of antinuclear and associated antibodies (
anti - dsDNA , anticardiolipin ,
anti - RNP , anti -
Sm ,
anti - SSA and anti -
SSB ) and/or combinations thereof in
systemic lupus erythematosus (
SLE ) patients with respect to their diagnostic and pathogenetic significance . -
pubmed
The prevalence of
anti - dsDNA antibodies was strongly influenced by the selection criteria of the patient ; the lowest prevalence was found in
SLE patients with central nervous system ( CNS ) involvement ; the highest prevalence in patients with
nephritis . -
pubmed
No difference in
anticardiolipin antibody prevalence between the different
SLE patient groups could be demonstrated . -
pubmed
Regarding antibodies against
RNP ,
Sm ,
SSA and
SSB , the prevalence was found to be strongly influenced by the criteria used for patient selection . -
pubmed
The effects of plasma lipids , blood
glucose , and serum total
cholesterol ,
LDL -
cholesterol ,
VLDL -
cholesterol , 6 - month period were studied in 18
patients with
essential hypertension . -
pubmed
The elevated release of
monokines , especially
interleukin I from monocytes of
rheumatoid arthritis patients triggered by
rheumatoid factors , immunocomplexes , complement compounds and other
serum factors , may explain the phenomenon . -
pubmed
Effect of
obesity on ambient plasma
glucose , free
fatty acid ,
insulin ,
growth hormone , and glucagon concentrations . -
pubmed
Fasting and postprandial plasma concentrations of
glucose ,
FFA ,
insulin , glucagon , and GH concentrations were determined in 10 nonobese and 10
obese subjects with normal
glucose tolerance . -
pubmed
Although plasma
glucose concentrations were similar throughout the 8 - h period in the 2 groups , plasma
insulin concentrations were significantly ( P less than 0.001 ) higher in the
obese individuals . -
pubmed
Immunogenicity of " single peak "
beef - pork
insulin in
diabetic subjects . -
pubmed
[
Prostaglandins and the
kallikrein - kinin systems in the normal pregnancy - puerperium cycle and in
hypertensive disease proper to pregnancy ] . -
pubmed
Five multiple forms of chemically cleaved inhibitors (
UTIB - I ,
UTIB - II ,
UTIB - III ,
UTIB - IV and
UTIB - V ) could be isolated from BrCN - treated L -
UTI by isoelectric focusing and gel filtration . -
pubmed
The production of
IgE antibody against
Candida albicans in atopic patients with
bronchial asthma ] . -
pubmed
[ New biochemical aspects of
diabetes : receptor problems and
insulin mutations ] . -
pubmed
Erythromycin has been shown to act on
motilin receptors on gastrointestinal smooth muscle in vitro and to accelerate gastric emptying in normal
subjects as well as in
patients with
diabetic mellitus . -
pubmed
The
T47D (
A1 - 2 ) cell line is a
human mammary carcinoma - derived cell line that has been engineered to constitutively express comparable levels of both
glucocorticoid and progesterone receptors . -
pubmed
A subset of
patients ( 50 % ) with
neuroborreliosis (
Lyme disease ) showed
IgG reactivity to
cardiolipin in solid phase ELISA . -
pubmed
In addition , a subset of
patients with
neuroborreliosis ( 29 % ) and
syphilis ( 59 % ) had
IgM reactivity to
gangliosides with a
Gal ( beta 1 - 3 ) GalNac terminal sequence (
GM1 ,
GD1b , and
asialo GM1 ) . -
pubmed
Anti - ganglioside IgM antibodies were significantly more frequent in these two groups of
patients compared to
patients with cutaneous and articular
Lyme disease ,
primary antiphospholipid syndrome ,
systemic lupus erythematosus and normal controls . -
pubmed
Given the clinical associations of
patients with
neuroborreliosis and
syphilis with
IgM reactivity to
gangliosides sharing the
Gal ( beta 1 - 3 ) GalNac terminus , we suggest that these antibodies could represent a response to injury in
neurological disease or a cross reactive event caused by spirochetes . -
pubmed
This study investigates the reliability of
glycated haemoglobin , measured by electroendosmosis or by affinity chromatography ,
fructosamine , and
albumin adjusted
fructosamine , as indices of glycaemic control in
Type 1 diabetes complicated by
chronic renal failure . -
pubmed
The regression equations did not differ significantly between subjects with
renal failure and those with normal renal function , suggesting that similar ranges can be used in interpreting glycated
haemoglobin results from each group of patients . -
pubmed
Two hundred and twenty - eight
HIV positive individuals underwent motor and sensory nerve conduction studies , CSF evaluation , peripheral
CD4 - T lymphocyte count , and neurologic evaluation to determine the presence or absence of
peripheral neuropathy . -
pubmed
We also compared CSF parameters in a subset of
CD4 - matched
patients with and without
neuropathy . -
pubmed
Allelic variability in D21S11 , but not in
APP or
APOE , is associated with
cognitive decline in
Down syndrome . -
pubmed
Genetic variation in the
APOE gene and variation in chromosome 21 genotypes , including the
APP locus , may influence age - associated
cognitive decline in adults with
Down syndrome . -
pubmed
Genetic variability at
APOE and
APP was not significantly associated with evidence of
cognitive decline . -
pubmed
Responses of lean and
obese Zucker
rats to centrally administered
leptin . -
pubmed
Obese ( Lepr(fa)/Lepr(fa ) ) Zucker
rats have a missense mutation in the
leptin receptor gene . -
pubmed
However , conflicting reports exist on whether
obese Zucker
rats can respond to centrally administered
leptin . -
pubmed
administered
leptin and to compare the responses of lean and
obese Zucker
rats . -
pubmed
Both single and daily
leptin administration also decreased respiratory quotient ( RQ ) similarly in lean and
obese Zucker
rats , indicating mobilization of fat as an energy source for
leptin - treated
rats . -
pubmed
After withdrawal of daily
leptin treatment , lean and
obese Zucker
rats exhibited different recovery responses . -
pubmed
It is concluded that
obese Zucker
rats can respond to exogenous
leptin when
leptin is delivered into the brain ventricles . -
pubmed
We found that the
MTHFR T / T genotype was strongly correlated with
intermediate hyperhomocysteinemia , being present in 73.9 % of those cases ( 17 of 23 ) . -
pubmed
This indicates that a search for
CBS mutations in patients with severe
hyperhomocysteinemia is important to ensure the detection of a possible
CBS deficiency , thus enabling treatment . -
pubmed
Co - existence of the
MTHFR T / T genotype and the common CBS 844ins68 variant was significantly higher among patients ( 10.7 % ) as compared to controls ( 1.2 % ) , indicating that this genotype combination is a
thrombotic risk factor ( P & lt;0.05 ) . -
pubmed
Despite the high virus titers , rCVB3
infection of naive
mice failed to induce a strong
CD8 + T - cell response to the encoded epitope ; this has implications for the proposed role of " cross - priming " during
virus infection and for the utility of recombinant picornaviruses as vaccine vectors . -
pubmed
These anti - invasive effects appear to be mediated through the downregulation of
MMP-2 (
matrix metalloproteinase ) and the upregulation of
TIMP-1 (
tissue inhibitor of metalloproteinase ) , 2 common effector molecules that have been implicated in regulating
tumor cell invasion . -
pubmed
Polyclonal antibodies have been generated to the cloned
urea transporter proteins , and the use of these antibodies in integrative
animal studies has resulted in several novel findings , including : ( 1 ) the surprising finding that
UT - A1 protein abundance and
urea transport are increased in the inner medulla during conditions in which urine concentrating ability is reduced ; ( 2 )
vasopressin increases
UT - A1 phosphorylation in
rat inner medullary collecting duct ; ( 3 )
UT - A protein abundance is upregulated in
uremia in both liver and heart ; and ( 4 )
UT - B is expressed in many nonrenal tissues and endothelial cells . -
pubmed
This review will summarize the knowledge gained from using molecular approaches to perform integrative studies into
urea transporter protein regulation , both in normal
animals and in
animal models of
human diseases , including studies of
uremic rats in which
urea transporter protein is upregulated in liver and heart . -
pubmed
Although
flurbiprofen abolished endotoxin - induced
fever , which is a centrally generated ,
prostaglandin - mediated response , it failed to reverse blockade of the
LH surge . -
pubmed
Four polymorphisms were evaluated , including the
serotonin transporter
HTTLPR promoter ins / del ,
GABAAalpha6 Pro385Ser ,
NPY Leu7Pro , and
catalase 262C>T. Two of these , HTTLPR and
GABAAalpha6 Pro385Ser , had been previously associated with
LR and
alcoholism in a preliminary study . -
pubmed
CONCLUSIONS : This report strengthens the support for a relationship between the
HTTLPR L and
GABAAalpha6 Ser385 alleles to low
alcohol LR and to
alcoholism in a prospectively studied cohort evaluated for
LR in young adulthood and before the onset of
alcohol dependence . -
pubmed
Several lines of evidence suggest that
D - serine , an endogenous agonist of the
glycine site on the
NMDA receptors , might play a role in the pathophysiology of
schizophrenia . -
pubmed
This study suggests that synthetic or metabolic pathways of
D - serine may be abnormal in the brain of drug - naive
schizophrenic patients , supporting the
NMDA receptor dysfunction hypothesis of
schizophrenia . -
pubmed
Several differences were noted between the amount of
collagen present according to
hydroxyproline measurement and the stages of
fibrosis according to histology . -
pubmed
CONCLUSIONS : Although increases in
collagen content ( by
hydroxyproline ) approximately paralleled increases in
fibrosis stage ( by histology ) , there was considerable overlap and some discrepancies . -
pubmed
Kinetics of prebeta1
HDL and
alphaHDL in
type II diabetic patients . -
pubmed
BACKGROUND : The aim of this study was to analyze the recycling of
high density lipoprotein (
HDL ) in six
type II diabetic patients compared with six control subjects by endogenous labelling of
apolipoprotein A - I (
Apo A - I ) with stable isotope
Apo A. -
pubmed
RESULTS : Plasma
Apo A - I concentration was decreased in
patients with
type II diabetes as a result of a decrease in
Apo A - I -
alphaHDL ( P & lt ; 0.05 ) . -
pubmed
Diabetic patients were also characterized by an increased relative contribution of
Apo A - I in prebeta1
HDL ( 18.3 + /- 2.8 % vs 11.9 + /- 3.7 % , P & lt ; 0.01 ) . -
pubmed
The synthetic rate of prebeta1
HDL was slightly increased in
diabetic patients compared with control ( NS ) and an increase of recycling rate of alpha to prebeta1
HDL was observed ( 11.67 + /- 3.14 d(-1 ) vs 7.09 + /- 4.51 d(-1 ) , P & lt ; 0.05 ) . -
pubmed
The clearance rate of
Apo A - I was higher in
diabetic patients ( P & lt ; 0.05 for
Apo A - I - prebeta1
HDL and P & lt ; 0.005 for
Apo A - I - alphaHDL ) . -
pubmed
CONCLUSION : This study suggests that the usual increase in prebeta1
HDL in
type II diabetic patients is mainly related to an increased conversion rate of alpha to prebeta1
HDL . -
pubmed
The use of
B - type natriuretic peptide in the management of
patients with
diabetes and acute
dyspnoea . -
pubmed
AIMS / HYPOTHESIS : The aim of this study was to determine the impact of measurement of
B - type natriuretic peptide (
BNP ) levels on the management of
patients with
diabetes presenting with acute
dyspnoea . -
pubmed
METHODS : This study evaluated the subgroup of 103
patients with
diabetes included in the
B - type Natriuretic Peptide for Acute Shortness of Breath Evaluation ( BASEL ) study ( n=452 ) . -
pubmed
CONCLUSIONS / INTERPRETATION : The results of this study indicate that measurement of
BNP levels improves the management of
patients with
diabetes presenting with acute
dyspnoea . -
pubmed
This article focuses on the mechanisms by which hormone resistance develops , including the reactivation of
androgen receptor during
androgen deprivation therapy , the role of
cancer stem cells , and the emergence of epithelial - mesenchymal transition cells , which have increased metastatic potential . -
pubmed
[
Hydrogen sulphide water balneum effect on erythrocyte
catalase activity in
patients with
rheumatoid arthritis -- in vitro study ] . -
pubmed
The aim of the study was to investigate , in vitro ,
hydrogen sulphide water ( HSW ) balneum effect on erythrocyte
catalase activity in
patients with
rheumatoid arthritis . -
pubmed
The mean baseline erythrocyte
catalase activity ( to ) was in
rheumatoid arthritis patients of about 7.79 + /- 1.39 U / gHb and was significantly higher than in the control group : 6.96 + /- 2.68 U / gHb ( p & lt ; 0.05 ) . -
pubmed
After 5 minutes incubation with HSW ( t5 ) erythrocyte
catalase activity increased , in
rheumatoid arthritis patients to 8.21 + /- 1.77 U / gHb , after 10 minutes ( t10 ) was 8.14 + /- 2.25 U / gHb , in control group : 7.58 + /- 2.50 U / gHb and 7.68 + /- 3.22 U / gHb , respectively . -
pubmed
After 20 minutes of incubation ( t20 ) erythrocyte
catalase activity was the highest in the
patients with active
rheumatoid arthritis ( 8.33 + /- 1.96 U / gHb ) and differed significantly from the
patients in remission ( 6.69 + /- 1.27 U / gHb ) and from
patients not receiving non - steroidal anti - inflammatory drugs ( 6.04 + /- 1.08 U / gHb ) . -
pubmed
In
rheumatoid arthritis patients erythrocyte
catalase activity was higher when compared with control group and increased during incubation with HSW . -
pubmed
Insulin sensitivity ( assessed by homeostasis model assessment 2 modeling ) ,
androgen , and
HDL cholesterol levels were significantly decreased , whereas total fat mass and
LDL cholesterol ,
triglyceride ,
CRP ,
leptin , and
fructosamine levels were significantly increased in untreated
Klinefelter ' s syndrome patients . -
pubmed
In treated
Klinefelter ' s syndrome patients ,
LDL cholesterol and
adiponectin were significantly decreased , whereas no difference in body composition was found in comparison with untreated
Klinefelter ' s syndrome patients . -
pubmed
Peroxisome proliferator - activated receptor gamma and growth inhibition by its ligands in
uterine endometrial carcinoma . -
pubmed
PURPOSE : In this study , we evaluated the correlation between
endometrial carcinoma and
peroxisome proliferator - activated receptor gamma (
PPARgamma ) expression and assessed whether
PPARgamma ligands influence
carcinoma growth . -
pubmed
EXPERIMENTAL DESIGN : We examined the presence and cellular distribution of
PPARgamma protein in 42
normal endometria , 32 endometria with
hyperplasia , and 103 endometria with
endometrial carcinoma by immunohistochemistry . -
pubmed
We then compared
PPARgamma mRNA expression in
endometrial carcinoma with that in
normal endometria using real - time reverse transcription - PCR . -
pubmed
We subsequently confirmed expression of
PPARgamma mRNA by real - time reverse transcription - PCR and
PPARgamma protein by immunoblotting in
endometrial carcinoma cell lines (
Ishikawa ,
Sawano , and
RL95 - 2 cells ) . -
pubmed
We further examined the effects of
PPARgamma agonist
15 - deoxy - Delta12,14 - prostaglandin J2 (
15d - PGJ2 ) , a naturally occurring
PPARgamma ligand , to these
endometrial carcinoma cell lines . -
pubmed
We also examined the status of apoptosis and
p21 mRNA expression of these
endometrial carcinoma cell lines following addition of
15d - PGJ2 . -
pubmed
RESULTS :
PPARgamma immunoreactivity was detected in 11 of 23 ( 48 % ) of proliferative - phase endometrium , 14 of 19 ( 74 % ) of secretory - phase endometrium , 27 of 32 ( 84 % ) of
endometrial hyperplasia , and 67 of 103 ( 65 % ) of
carcinoma cases . -
pubmed
PPARgamma immunoreactivity was significantly lower in endometrial
carcinoma than in secretory - phase endometrium ( P = 0.012 ) and
endometrial hyperplasia ( P = 0.006 ) . -
pubmed
There was a significant positive association between the status of
PPARgamma and
p21 expression in endometrial
carcinoma ( P & lt ; 0.0001 ) . -
pubmed
There was a significant negative association between the body mass index and
PPARgamma labeling index of
carcinoma tissue in the
patients with
endometrial carcinoma ( P & lt ; 0.0001 ) . -
pubmed
PPARgamma mRNA was expressed abundantly in
normal endometria but not in
endometrial carcinoma . -
pubmed
We showed that
PPARgamma agonist
15d - PGJ2 inhibited cell proliferation and induced
p21 mRNA of
endometrial carcinoma cell lines . -
pubmed
CONCLUSION : We showed the expression of
PPARgamma in
human endometrial carcinoma and the effects of
PPARgamma ligand in
endometrial carcinoma cells . -
pubmed
These findings suggest that a
PPARgamma ligand ,
15d - PGJ2 , has antiproliferative activity against
endometrial carcinoma . -
pubmed
Suppression of carrageenan- and
collagen II - induced
inflammation in
mice by geranium oil . -
pubmed
To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for
inflammatory diseases , we examined the effects of geranium oil on carrageenan - induced and
collagen II - induced
inflammation in
mice , to assess acute and chronic anti - inflammatory activities of the oil . -
pubmed
Single intraperitoneal injection of 5 mu L of geranium oil clearly suppressed the carrageenan - induced footpaw
edema and increase in tissue
myeloperoxidase activity , and repeated administration of the oil suppressed collagen - induced
arthritis . -
pubmed
We have previously validated transgenic
mice overexpressing the
neurotrophin-3 (
NT-3 ) receptor ,
TrkC (
TgNTRK3 ) , as an engineered
murine model of
panic disorder . -
pubmed
We could determine that
TgNTRK3 mice presented increased cellularity in brain regions , such as the locus ceruleus , that are important neural substrates for the expression of
anxiety in severe
anxiety states . -
pubmed
Here , we investigated the sensitivity to induce
anxiety and
panic - related symptoms by
sodium lactate and the effects of various drugs ( the
alpha2 - adrenoceptor antagonist ,
yohimbine and the
adenosine antagonist ,
caffeine ) , in TgNTRK3
mice . -
pubmed
Our findings validate the relevance of the
NT-3 /
TrkC system to pathological
anxiety and raise the possibility that a specific set of fear - related pathways involved in the processing of
anxiety - related information may be differentially activated in
panic disorder . -
pubmed
All muscles injected with
botulinum toxin showed decreased wet weight and persistent
weakness upon completion of the study . -
pubmed
Injection of
botulinum toxin in the gastrocnemius may minimize
equinus contracture and protect the anterior tibialis from damage during
human tibial lengthening . -
pubmed
Reverse transcriptase polymerase chain reaction was used to further examine the expression pattern of these genes during
soybean infection . -
pubmed
PURPOSE : Ovarian suppression with
luteinizing hormone - releasing hormone (
LHRH ) agonists is an effective adjuvant treatment for premenopausal
women with
estrogen receptor ( ER ) - positive breast cancer . -
pubmed
PATIENTS AND METHODS : This randomized phase III trial was performed to compare the 3 - monthly depot
LHRH agonist
leuprorelin acetate (
LAD-3 M ; n = 299 ) and chemotherapy with
cyclophosphamide ,
methotrexate , and
fluorouracil (
CMF ; n = 300 ) in pre- or perimenopausal
patients with
ER - positive , node - positive
breast cancer . -
pubmed
CONCLUSION : The 3 - monthly depot
LHRH - agonist
leuprorelin acetate is an effective adjuvant treatment in premenopausal
patients with
hormone receptor - positive , node - positive
breast cancer that is not inferior to
CMF . -
pubmed
DATA SOURCES : Comprehensive search using keywords
AVP receptor antagonists ,
hyponatremia ,
SIADH ,
conivaptan ,
tolvaptan ,
lixivaptan , nurse practitioner , and others was carried out using the National Library of Medicine ( PubMed ) Web site from which full - text articles were obtained . -
pubmed
In clinical trials , a new class of drugs called the
arginine vasopressin ( AVP ) receptor antagonists or aquaretics has been shown to be safe and effective for the treatment of
hyponatremia . -
pubmed
The association of
interferon with the development of
pulmonary tuberculosis . -
pubmed
We report a new case of a patient suffering from
chronic hepatitis C (
CHC ) and treated with
interferon - alpha2a (
IFN - alpha ) who presented with the diagnosis of active
pulmonary tuberculosis . -
pubmed
Our case demonstrates a rare association between
interferon and
tuberculosis since only one case in the literature has described a similar association . -
pubmed
These latter genes are involved in
tau protein phosphorylation , and their increased expression in
hydrocephalus was confirmed by real - time polymerase chain reaction analysis . -
pubmed
CONCLUSIONS : The accumulation of phosphorylated
tau protein in the cerebral cortex may be one of the mechanisms by which later
cognitive dysfunction develops in
patients with compensated
hydrocephalus . -
pubmed
More work needs to be done to determine if the accumulation of phosphorylated
tau in the cortex can help predict which
patients may decompensate thus requiring more aggressive treatment for compensated
hydrocephalus . -
pubmed
RESULTS : The findings demonstrate that when receiving the reflexology treatment condition , as compared to the control condition , the
residents demonstrated significant reduction in observed
pain and salivary
alpha - amylase . -
pubmed
The most frequent subtype of
autosomal dominant inherited spinocerebellar ataxias is caused by CAG repeat expansions of more than 55 units in the
ataxin-3 gene . -
pubmed
We have included the Gunn
rat as a model of an
inherited liver disease without hepatocyte damage and
Abcb4 knockout
mice as a model for an
inherited liver disease with
hepatocyte damage . -
pubmed
We describe problems that can be encountered in the maintenance and breeding of Gunn
rats and
immunodeficient Rag2 / gamma common knockout
mice . -
pubmed
In the present study , we examined the relevance of the apoptosis repressor with
caspase recruitment domain (
ARC ) on cardiac myocyte survival and its underlying mechanisms in a model of
Dox - induced
cardiotoxicity . -
pubmed
In this study , we provide evidence for the protective role of anti - apoptotic
ARC in
Dox - induced
cardiotoxicity , which makes this molecule an interesting target for future therapies . -
pubmed
Chimeric antigen T cell receptors provide a good approach for adoptive immunotherapy of
cancer , especially in the context of cancerous cells that fail to express
major histocompatibility complex antigen and co - stimulatory molecules . -
pubmed
MUC1 is a highly attractive immunotherapeutic target owing to increased expression , altered glycosylation , and loss of polarity in more than 80 % of
human malignancies . -
pubmed
If sufficient conditions arise , genetic factors that influence the expression of
CRB1 mutations in
Coats - like retinitis pigmentosa should be detected . -
pubmed
Histone deacetylases (
HDACs ) are enzymes involved in
tumor genesis and development . -
pubmed
Functional analysis of two single
nucleotide polymorphisms in
SLC30A2 (
ZnT2 ): implications for mammary gland function and
breast disease in women . -
pubmed
Isocitrate dehydrogenase 1 analysis differentiates
gangliogliomas from
infiltrative gliomas . -
pubmed
Recent work has identified novel point mutations in
isocitrate dehydrogenase 1 (
IDH1 ) in the majority of the World Health Organization grades II and III infiltrative
gliomas and
secondary grade IV glioblastomas . -
pubmed
In this multi - institutional study , 98 cases originally diagnosed as
ganglioglioma were analyzed for
IDH1 mutations , 86 of which had follow - up data available . -
pubmed
The presence of mutant
IDH1 in
gangliogliomas correlated with a greater risk of recurrence ( P=0.0007 ) and malignant transformation and/or death ( P<0.0001 ) compared with
tumors that were
IDH1 wild type . -
pubmed
Furthermore , the age of patients with
IDH1 - mutant
gangliogliomas was higher than those without mutations ( 25.5 vs. 46.1 years , P=0.0033 ) . -
pubmed
IDH1 / 2 testing of
tumors suspected of being
gangliogliomas may therefore be advisable , particularly in the adult population . -
pubmed
Mutations in
eomesa /
tbr2 cause
microcephaly in
humans , whereas
lhx2b is a critical regulator of cell fate and axonal targeting in the developing forebrain . -
pubmed
These results demonstrate the feasibility of employing genomic SELEX to identify
vertebrate transcription factor binding sites and target genes and reveal
Fezf2 as a transcription activator and a candidate for evaluation in
human microcephaly . -
pubmed
Several examined
hyperkalemia associated with
angiotensin - converting enzyme ( ACE )- inhibitor /
angiotensin II receptor blocker ( ARB ) , diuretic (
potassium - sparing ) , and beta - blocker use . -
pubmed
Finally ,
orthostatic hypotension was evaluated in those taking
ACE - inhibitor / ARB , beta - blocker , or
calcium - channel blocker therapy . -
pubmed
The role of
p27 ( Kip1 ) in
dasatinib - enhanced
paclitaxel cytotoxicity in
human ovarian cancer cells . -
pubmed
METHODS : A library of silencing RNAs ( siRNAs ) was used to identify
kinases that regulate
paclitaxel sensitivity in
human ovarian cancer SKOv3 cells . -
pubmed
The effect of
dasatinib , an inhibitor of
Src and
Abl kinases , on
paclitaxel sensitivity was measured in
ovarian cancer cells and
HEY xenografts . -
pubmed
The siRNA knockdown of
Src ,
Fyn , or
Abl1 enhanced
paclitaxel - mediated growth inhibition in
ovarian cancer cells compared with a control siRNA . -
pubmed
CONCLUSION : Inhibition of
Src family and
Abl kinases with either siRNAs or
dasatinib enhances
paclitaxel sensitivity of
ovarian cancer cells through
p27(
Kip1)-mediated suppression of
Bcl-2 and
Cdk1 expression . -
pubmed
Many primary
human tumors and tumor cell lines highly express
human L - type amino acid transporter 1 (
hLAT1 ) ; cancerous cells in vivo are strongly linked to
LAT1 expression . -
pubmed
Combined genetic inactivation of
beta2 - Microglobulin and
CD58 reveals frequent escape from immune recognition in
diffuse large B cell lymphoma . -
pubmed
We report that
diffuse large B cell lymphoma (
DLBCL ) commonly fails to express
cell - surface molecules necessary for the recognition of
tumor cells by immune - effector cells . -
pubmed
In addition to gene inactivation , alternative mechanisms lead to aberrant expression of
HLA - I and
CD58 in & gt;60 % of
DLBCL . -
pubmed
A novel single - base deletion mutation of the
RUNX2 gene in a Chinese family with
cleidocranial dysplasia . -
pubmed
We identified a disease - causing mutation of the
RUNX2 gene in a four - generation Chinese family affected with
cleidocranial dysplasia (
CCD ) . -
pubmed
We demonstrated that a novel mutation ( c.549delC ) of
RUNX2 is associated with
CCD in a Chinese family , adding to the repertoire of
RUNX2 mutations related to
CCD . -
pubmed
Finally ,
Staufen affects HIV and
influenza infection at several levels . -
pubmed
To date ,
peptide receptor radionuclide therapy seems to be an acceptable option and is relatively safe in adult advanced
NET patients with receptor uptake positive on scintigraphy , but
patients ' renal function must be monitored . -
pubmed
Role of
nuclear factor ( erythroid - derived 2 )- like 2 in metabolic homeostasis and
insulin action : A novel opportunity for
diabetes treatment ? -
pubmed
While oxidative stress is among the early events that lead to the development of
insulin resistance , the activation of
Nrf2 scavenging capacity leads to
insulin sensitization . -
pubmed
Here we summarize recent findings that link the
Nrf2 system to metabolic homeostasis and
insulin action and present our view that
Nrf2 may serve as a novel drug target for
diabetes and its complications . -
pubmed
Seven hundred and one
AD patients with at least 3 different cognitive evaluations and genotypic information for
APOE and 6 genome wide association study - significant single - nucleotide polymorphisms were selected for this study . -
pubmed
The
PICALM single - nucleotide polymorphism also displayed a significant effect protecting against rapid progression during pharmacogenetic assays although its observed effect displayed heterogeneity among
AD therapeutic protocols ( p = 0.039 ) . -
pubmed
Childhood
immune thrombocytopenia : role of rituximab , recombinant
thrombopoietin , and other new therapeutics . -
pubmed
However , because immunosuppressive agents such as rituximab are not approved for use in
ITP and the
thrombopoietin receptor agonists are not yet approved in children , the decision to use alternatives to splenectomy needs to be considered carefully . -
pubmed
Owing to the pleiotropic characteristics of the target ,
anti - TNF - alpha blockers may affect several mechanisms beyond
rheumatoid synovitis . -
pubmed
As
TNF - alpha plays a pivotal role in the induction of early
atherosclerosis , treatment with
TNF - inhibitors may modulate
cholesterol handling , in particular ,
cholesterol efflux from macrophages . -
pubmed
The efficacy of an
anti - C5 monoclonal antibody fused to a peptide targeting inflamed synovia in experimental
arthritis opened the way for new strategies : Homing to the synovium of molecules neutralizing
TNF would allow to maximize the therapeutic action avoiding the side effects . -
pubmed
Two of these genes (
FAM129A ,
SYNPO2 ) were associated with
airway hyperresponsiveness ( provocative concentration of
methacholine causing a 20 % drop in FEV1 : r = -0.740 , P & lt ; 0.01 ; r = -0.746 , P & lt ; 0.01 ) . -
pubmed
The derived function of
VDAC , therefore , might underlie the development of
autism . -
pubmed
The aim of this study was to compare the
U - II levels in knee synovial fluids obtained from
osteoarthritic and non - osteoarthritic
patients . -
pubmed
Levels of
U - II were measured by using ELISA kit
U - II levels were significantly higher in the
osteoarthritic group than that in the control group . -
pubmed
In conclusion , the significantly high
U - II levels in the knee synovial fluid of
osteoarthritic patients supported our hypothesis that " U - II may be associated with the
synovial fibrosis in
osteoarthritis " . -
pubmed
Anti -
vascular endothelial growth factors (
VEGF ) agents have revolutionized the treatment of
retinal diseases . -
pubmed
AIM : To assess differing patterns and levels of ascitic fluid
cyctokine and
growth factors exist between those with a high risk and low risk of spontaneous
bacterial peritonitis (
SBP ) . -
pubmed
Individuals with
alcoholic cirrhosis had the highest levels of
IL-1A ,
IL-1B ,
IL-4 ,
IFNgamma . -
pubmed
Those with
hepatitis C virus ( HCV ) associated cirrhosis had the highest value for
IL-6 ,
IL-8 ,
IL-10 ,
MCP-1 and
VEGF . -
pubmed
Those with
cardiac disease had the highest level of
TNF - alpha and
EGF . -
pubmed
The calculated serum- ascites gradients for the cardiac and malignant disease groups had a greater frequency of negative values signifying greater levels of
IL-8 ,
IL-10 and
MCP-1 in
ascites than did those with
alcohol or
HCV disease . -
pubmed
CONCLUSION : These data document important differences in the
cytokine and
growth factor levels in plasma , ascitic fluid and the calculated plasma - ascites fluid gradients in
cirrhotics requiring a large volume paracentesis . -
pubmed
[ The role of allogeneic hematopoietic stem cell transplant in therapy of
chronic myeloid leukemia in the era of
tyrosine kinase inhibitors ] . -
pubmed
BACKGROUND :
Asymmetric dimethylarginine (
ADMA ) , the main endogenous inhibitor of
nitric oxide synthase , is considered to be associated with
endothelial dysfunction . -
pubmed
METHODS : This was a single arm , prospective , observational multicenter and phase IV clinical trial for 279
patients , who were newly diagnosed as
CD20 - positive
DLBCL from 24 medical centers in China 2011 and 2012 , no special exclusion criteria were used . -
pubmed
Elevated levels of
sFlt1 were associated with a 2.8 - fold increased risk of
hypothyroxinemia ( P = .04 ) . -
pubmed
Decreased levels of
PlGF were associated with a 6.7 - fold increased risk of
hypothyroxinemia ( P & lt ; .001 ) . -
pubmed
Within the normal range , a dose - dependent effect of
sFlt1 on
thyroid dysfunction was observed : high - normal
sFlt1 levels were associated with a 17.7 - fold increased risk of
hypothyroxinemia ( P & lt ; .001 ) and a 2.7 - fold increased risk of
hyperthyrotropinemia ( P = .01 ) . -
pubmed
Abnormal as well as normal - range fetal
sFlt1 and
PlGF levels influence the risk of
impaired newborn thyroid function , which has been associated with adverse neurodevelopmental effects . -
pubmed
This study is the first report which demonstrates the cartilage protective effect of
5,7,3 ' , 4 '- tetramethoxyflavone (
TMF ) by decreasing the concentration of
IL-1beta ,
TNF - alpha and
PGE2 in the knee synovial fluid in
OA rat models in vivo . -
pubmed
Serum levels of miR-197 and miR-10b were inversely correlated with degree of
inflammation and miR-181d and miR-99a were inversely correlated with serum
gamma glutamyl transferase levels in
non - alcoholic steatohepatitis patients . -
pubmed
However , modeling and experimental studies on the intravenous anesthetic
propofol indicate that potentiation of
gamma - aminobutyric acid receptors leads to a state of thalamocortical synchrony , observed as coherent frontal alpha oscillations , associated with
unconsciousness . -
pubmed
RESULTS : On transplantation , the peripheral
CD19CD24CD38 transitional B cell subset strongly declined , regardless of the subsequent occurrence of
AR . -
pubmed
In contrast ,
TCL1A expression levels increased in stable
patients , but decreased in
patients at the time of
AR in both PBMC and isolated B cells . -
pubmed
At the time of
AR ,
CD79B gene expression was significantly lower compared to stable
patients , being most apparent in the B - cell fraction . -
pubmed
Differences in expression of proliferation - associated genes and
RANKL across the menstrual cycle in
estrogen receptor - positive primary
breast cancer . -
pubmed
The purpose of this study is to determine if there are differences in the expression of
estrogen - regulated genes ( ERGs ) , proliferation - associated genes and the
progesterone effector
RANKL , in premenopausal
ER + breast cancer as a result of the major changes in hormone levels that occur through the menstrual cycle . -
pubmed
Primary
ER+
tumours from 174
patients were assigned to one of three menstrual cycle windows : W1 ( days 27 - 35 + 1 - 6 ) , W2 ( days 7 - 16 ) and W3 ( days 17 - 26 ) . -
pubmed
Expression of proliferation - associated genes and
RANKL in ER+ breast
tumours varies across the menstrual cycle showing a different rhythm to that of ERGs . -
pubmed
Following investigation to exclude the usual causes of
toxicity , it was surmised that impaired
CYP1A2 function , secondary to the acute inflammatory process , had led to a toxic level of the drug . -
pubmed
The relationship between
semaphorin 3C and microvessel density in the progression of
breast and oral neoplasia . -
pubmed
This study aimed to identify the expression of
semaphorin 3C (
SEMA3C ) in the normal - metastatic spectrum of
breast and oral cancers , and correlate expression with microvessel density ( MVD ,
CD31 ) , a surrogate marker of angiogenesis . -
pubmed
Histological analysis revealed that
SEMA3C expression was reduced in the development of
oral cancer from
normal oral tissue ( P<0.0001 ) and expression was inversely correlated with
MVD ( r=-0.394 , P=0.05 ) . -
pubmed
In contrast ,
SEMA3C expression increased in the transition from
normal to
invasive breast disease in epithelial /
tumour cells ( P=0.001 ) and endothelial cells ( P=0.006 ) , with both correlating weakly with
MVD ( r=0.35 , p=0.03 and r=0.243 , p=0.041 respectively ) . -
pubmed
Furthermore , histological analysis of a
breast cancer tissue microarray revealed a weak positive correlation with
tumour grade ( r=0.305 , P=<0.001 ) and biological phenotype ( r=0.237 , p=0.004 ) with
tumour cell expression of
SEMA3C highest in triple negative and
ER- ,
PR- ,
HER2 + subtypes . -
pubmed
These data suggest that
SEMA3C expression is differentially regulated in the development and progression of
breast versus oral neoplasia , and that increased expression of
SEMA3C may be modulating
breast cancer progression and angiogenesis , and could represent a biomarker of
metastatic disease . -
pubmed
RESULTS : The prevalence of vagal reflex on
patients in treatment group was significantly lower than that in the control group , with statistically significant difference ( p & lt ; 0.05 ) ; low frequency ( LF ) and high frequency ( HF ) on
patients from both groups decreased after treatment while LF /
HF increased , and LF and
HF on
patients of the treatment group decreased more significantly and LF /
HF increased more significantly than those of the control group , with statistically significant difference ( p & lt ; 0.05 ) ; the concentration of
TNF - alpha and
IL-6 on both groups of
patients after nursing also decreased , and the treatment group decreased more significantly , with statistically significant difference ( p & lt ; 0.05 ) . -
pubmed
LTRs with
hepatic steatosis had higher serum concentrations of
small - dense low - density lipoprotein cholesterol (
sdLDL - C ; 34.8 + - 16.9 versus 22.7 + - 11.2 mg / dL ; P & lt ; 0.001 ) ,
sdLDL - C to
low - density lipoprotein cholesterol ratio ( 32.6 + - 11.6 versus 24.6 + - 10.2 ; P & lt ; 0.01 ) ,
small - dense low - density lipoprotein particle concentration (
sdLDL - P ; 770 + - 440 versus 486 + - 402 nmol / L ; P & lt ; 0.01 ) ,
very low density lipoprotein particle concentration (
VLDL - P ; 7.90 + - 7.91 versus 3.86 + - 3.18 nmol / L ; P & lt ; 0.01 ) , and
very low density lipoprotein size (
VLDL - size ; 51.9 + - 6.4 versus 48.7 + - 6.3 nm ; P = 0.06 ) . -
pubmed
LTRs with
hepatic steatosis had higher serum
insulin concentrations ( 27.8 + - 41.8 versus 11.7 + - 7.8 uU / mL ; P & lt ; 0.01 ) but similar fasting
glucose and
hemoglobin A1c . -
pubmed
Steatosis grade was directly related to
sdLDL - C ,
sdLDL - P ,
insulin ,
VLDL - P , and
VLDL - size . -
pubmed
In multivariate analysis , the association between
steatosis grade and
sdLDL - C ( beta = 0.03 ; P = 0.029 ) ,
VLDL - size ( beta = 0.316 ; P = 0.04 ) , and
low - density lipoprotein particle size ( beta = -0.27 ; P = 0.05 ) was independent of sex , body mass index , age ,
diabetes mellitus , time from transplant , and indication for LT . -
pubmed
IL-22 promotes the proliferation of
cancer cells in smoking
colorectal cancer patients . -
pubmed
We found that the serum concentrations of
CRC nonsmokers and
CRC smokers were skewed toward Th17 - type
cytokines , including
interleukin ( IL )- 17 and
IL-22 . -
pubmed
Notably , smoking
CRC subjects had significantly higher levels of
IL-22 than nonsmoking
CRC patients . -
pubmed
We also observed higher percentages of
CCR4(+)
CCR6(+ ) Th17 cells in circulating blood and higher secretion of
IL-17 and
IL-22 by peripheral blood mononuclear cells ( PBMCs ) of nonsmoking
CRC and smoking
CRC patients , compared to healthy individuals . -
pubmed
Again , we observed elevated
IL-17 and
IL-22 secretion by
CRC smokers than nonsmokers . -
pubmed
Since
IL-22 has been shown to stimulate tumorigenesis , which was also replicated in our experiments using
cancer cell line model , we tested whether
CRC patients ' cell culture supernatant could also support
tumor growth using this model . -
pubmed
In addition , we found that the
IL-22 concentration in
normal gut tissue of the smoking
CRC patients was significantly increased compared to that in nonsmoking
CRC subjects , while no significant differences were observed in
tumor tissues . -
pubmed
Our results suggest that chronic smokers may have higher risk for
CRC and worse prognosis due to dysregulated
IL-22 production . -
pubmed
Endoscopic resection ( ER ) of undifferentiated - type early
gastric cancer ( UD -
EGC ) has a lower curative resection ( CR ) rate than does
ER of differentiated - type
EGC ( D - EGC ) . -
pubmed
Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant
Human Hypoxia - Inducible Factor 1 - alpha (
HIF1 - alpha ) in an Ovine Model of
Acute Myocardial Infarction . -
pubmed
Hypoxia - inducible factor 1 - alpha (
HIF1 - alpha ) , rapidly degraded during normoxia , is stabilized during
ischemia and upregulates various cardioprotective genes . -
pubmed
We hypothesized that BMMSCs engineered to overexpress mutant ,
oxygen - resistant
HIF1 - alpha would confer greater cardioprotection than nontransfected BMMSCs in
sheep with
AMI . -
pubmed
METHODS AND RESULTS : Allogeneic BMMSCs transfected with a minicircle vector encoding mutant
HIF1 - alpha (
BMMSC - HIF ) were injected in the peri -
infarct of
sheep ( n=6 ) undergoing
coronary occlusion . -
pubmed
Interferon - gamma Aggravated
L - Arginine - Induced Acute
Pancreatitis in
Sprague - Dawley Rats and Its Possible Mechanism :
Trypsinogen Activation and Autophagy Up - regulation . -
pubmed
OBJECTIVES : It has been confirmed that the initiation of acute
pancreatitis (
AP ) involves intracellular
trypsinogen activation and local
cytokines release during its early stage . -
pubmed
The former is related to
autophagic disorder , and the latter is resulting from
nuclear factor - kappaB activation . -
pubmed
However , the effects of
interferon - gamma (
IFN - gamma ) on
AP are controversial . -
pubmed
This study is designed to elucidate the effects of
IFN - gamma on
AP severity and explore its impacts on the major mechanisms of
AP . -
pubmed
The effects of
IFN - gamma on the severity of
AP ,
trypsinogen activation peptide , and
tumor necrosis factor alpha ,
Interleukin-1 ,
Interleukin-6 levels , and autophagy activity were detected . -
pubmed
CONCLUSIONS :
Interferon - gamma aggravated
L - arginine - induced
AP in
Sprague - Dawley rats and led to intracellular
trypsinogen activation and inflammatory response . -
pubmed
The role of the
transient receptor potential ankyrin type-1 (
TRPA1 ) channel in
migraine pain : evaluation in an
animal model . -
pubmed
BACKGROUND : Clinical and experimental studies have pointed to the possible involvement of the
transient receptor potential ankyrin type-1 (
TRPA1 ) channels in
migraine pain . -
pubmed
In this study , we aimed to further investigate the role of these channels in an
animal model of
migraine using a novel
TRPA1 antagonist ,
ADM _ 12 , as a probe . -
pubmed
The expression levels of the genes coding for
c - Fos ,
TRPA1 ,
calcitonin gene - related peptide (
CGRP ) and
substance P (
SP ) in peripheral and central areas relevant for
migraine pain were analyzed . -
pubmed
CONCLUSIONS : These findings support a critical involvement of
TRPA1 channels in the pathophysiology of
migraine , and show their active role in counteracting
hyperalgesia at the trigeminal level . -
pubmed
L - mimosine induces
caspase-9 - mediated apoptosis in
human osteosarcoma cells . -
pubmed
Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the
hypoxic ventilatory response . -
pubmed
A long functional isoform of
leptin receptor ,
LepRb , was detected in the carotid body ( CB ) , a key peripheral
hypoxia sensor . -
pubmed
However , the effect of
leptin on minute ventilation ( VE ) and the
hypoxic ventilatory response ( HVR ) has not been sufficiently studied . -
pubmed
Leptin increased carotid sinus nerve activity at baseline and in response to
hypoxia in vivo . -
pubmed
We conclude that
leptin acts on
LepRb in the CBs to stimulate breathing and HVR , which may protect against
sleep disordered breathing in
obesity . -
pubmed
The objectives of the current study were ( 1 ) to examine the effect of subcutaneous
leptin infusion on minute ventilation ( VE ) and the
hypoxic ventilatory response to 10 %
O2 ( HVR ) in C57BL/6J
mice before and after CB denervation ; ( 2 ) to express
LepRb in CB of LepRb -deficient obese db / db
mice and examine its effects on breathing during sleep and wakefulness and on HVR . -
pubmed
In C57BL/6J
mice ,
leptin increased VE from 1.1 to 1.5 mL / min / g during normoxia ( P & lt ; 0.01 ) and from 3.6 to 4.7 mL / min / g during
hypoxia ( P & lt ; 0.001 ) , augmenting HVR from 0.23 to 0.31 mL / min / g / Delta F I O 2 ( P & lt ; 0.001 ) . -
pubmed
In db / db
mice ,
LepRb expression in CB increased VE from 1.1 to 1.3 mL / min / g during normoxia ( P & lt ; 0.05 ) and from 2.8 to 3.2 mL / min / g during
hypoxia ( P & lt ; 0.02 ) , increasing HVR . -
pubmed
We conclude that
leptin acts in CB to augment VE and HVR , which may protect against
sleep disordered breathing in
obesity . -
pubmed
C - reactive protein and
procalcitonin profile in ventilator - associated lower
respiratory infections . -
pubmed
The aim of this study was to evaluate the ability of
C - reactive protein (
CRP ) and
procalcitonin ( PCT ) to differentiate between
VAT and
VAP . -
pubmed
Patients with the diagnosis of
VAT or
VAP microbiologically documented and with one measurement of
CRP and/or PCT on the day of diagnosis were included . -
pubmed
On the day of
infection diagnosis , the median
CRP was elevated in both groups but significantly higher in
VAP ( 18 mg / dL vs. 14 mg / dL , p = .001 ) . -
pubmed
CONCLUSION : Although PCT and
CRP presented lower values in VAT as compared to
VAP , there was a marked overlap of both biomarkers values in both VA - LRTI not allowing adequate discrimination . -
pubmed
A Case of
IgG4 - Related
Aortitis and
Pericarditis : Diagnostic Challenges and Natural History . -
pubmed
CASE REPORT In this case , incidental discovery of non - infectious
aortitis and
pulmonary mass lesions were the specific signs that led to the consideration of
IgG4 - RD . -
pubmed
Plasma Abeta42 / 40 Ratio Detects Early Stages of
Alzheimer ' s Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study . -
pubmed
OBJECTIVES : This study evaluated the potential of plasma
beta - amyloid (
Abeta ) biomarkers in identifying early stages of
AD and predicting cognitive decline over the following two years . -
pubmed
DESIGN : Total
plasma Abeta42 / 40 ratio ( TP42/40 ) was determined in 83 cognitively normal
individuals ( CN ) and 145
subjects with amnestic
mild cognitive impairment ( a - MCI ) stratified by an
FDG - PET AD - risk pattern . -
pubmed
Low
TP42 / 40 at baseline increased the risk of progression to
dementia by 70 % . -
pubmed
CONCLUSIONS :
TP42 / 40 demonstrated value in the identification of
individuals suffering a -
MCI , in the prediction of progression to
dementia , and in the detection of underlying
AD pathology revealed by
FDG - PET , Amyloid - PET and CSF biomarkers , being , thus , consistently associated with all the well - established indicators of
AD . -
pubmed
Dissected peripancreatic tissue margin is a critical prognostic factor and is associated with a
K - ras gene mutation in
pancreatic ductal adenocarcinoma . -
pubmed
We previously reported that the dissected pancreatic tissue margin ( DPM ) and the preoperative serum level of
carbohydrate antigen 19 - 9 (
preCA19 - 9 ) were independent prognostic factors in
pancreatic ductal adenocarcinoma (
PDAC ) . -
pubmed
K - ras gene mutation was significantly associated with
DPM ( P=0.0002 ) , and DPM - positive patients demonstrated recurrence of distant metastasis in 67 % of cases . -
pubmed
Furthermore , to the best of our knowledge , the current study was the first to discover that
DPM can represent a poor prognosis based putatively on its association with the
K - ras gene mutation . -
pubmed
The target of immune - checkpoint blocking is
cytotoxic T lymphocyte protein-4 (
CTLA-4 ) or blockade of
programmed death-1 (
PD-1 ) protein and its ligand
programmed death ligand 1 (
PD - L1 ) that they have been considered as
cancer immunotherapy in recent years . -
pubmed
A Novel Diagnostic Method for
Thyroid Follicular Tumors Based on Immunofluorescence Analysis of
p53 - Binding Protein 1 Expression : Detection of Genomic Instability . -
pubmed
It was previously demonstrated that
p53 - binding protein 1 (
53BP1 ) expression , based on immunofluorescence ( IF ) , can serve as a valuable biomarker to estimate the malignant potential of various
cancers . -
pubmed
This study aimed to elucidate the utility of
53BP1 NF expression as a biomarker to differentiate
follicular tumors (
FTs ) . -
pubmed
Methods : Associations between
53BP1 expression based on IF and histological types of
FTs were analyzed using 27 follicular
adenomas (
FAs ) , 28 minimally invasive
FCs , and 14 widely invasive
FCs . -
pubmed
Results : This study demonstrates differences in
53BP1 NF expression between FA and
FC . -
pubmed
Thus , based on a comparison of these two indicators of
GIN ,
53BP1 NF ( by IF ) was better able to estimate the
malignancy of
FTs compared to CNA ( by array comparative genomic hybridization ) . -
pubmed
Interestingly , IF revealed a heterogenous distribution of
53BP1 NF , which occurred more frequently in the invasive or subcapsular area than in the center of the
tumor , suggesting intratumoral heterogeneity of GIN in
FTs . -
pubmed
Conclusions : It is proposed that IF analysis of
53BP1 expression could be a novel diagnostic method to estimate the malignant potential of
FTs . -
pubmed
Novel
Isoxazole Derivatives with Potent
FXR Agonistic Activity Prevent
Acetaminophen - Induced
Liver Injury . -
pubmed
FXR ligands have shown effective in reducing
liver injury in several experimental and clinical settings . -
pubmed
This characterization resulted in the identification of a potent
FXR agonist , compound 20 that was orally active , and rescued
mice from
acute liver failure caused by
acetaminophen overdose in a
FXR - dependent manner . -
pubmed
Immunofluorescence analysis for
transforming growth factor beta (
TGF - beta ) pathway proteins was performed on the piriform cortex of
epileptic dogs . -
pubmed
A significantly higher cerebrospinal fluid to
serum albumin ratio was found in
dogs with
BBBD relative to
dogs with intact blood - brain barrier ( BBB ) . -
pubmed
Immunohistochemistry results suggested active
TGF - beta signaling and neuroinflammation in the piriform cortex of
dogs with
IE , showing increased levels of
serum albumin colocalized with
glial acidic fibrillary protein and
pSMAD2 in an area where
BBBD had been detected by linear DCE - MRI . -
pubmed
The agent targets
ALK , which is found on
neuroblastoma cells but not healthy cells , delivering a drug that causes DNA cross - links . -
pubmed
Researchers have found that the antibody - drug conjugate kills
ALK - expressing cells in vitro and increases survival in
mouse models of
neuroblastoma . -
pubmed
Novel
GDAP1 Mutation in a Vietnamese Family with
Charcot - Marie - Tooth Disease . -
pubmed
Background : Mutations of
GDAP1 gene cause autosomal dominant and autosomal recessive
Charcot - Marie - Tooth ( CMT ) disease and over 80 different mutations have been identified so far . -
pubmed
This study analyzed the clinical and genetic characteristics of a Vietnamese
CMT family that was affected by a novel
GDAP1 mutation . -
pubmed
Discussion : Our study expands the mutational spectrum of
GDAP1 - related
CMT disease with the new and unreported
GDAP1 variant . -
pubmed
Alterations in
GDAP1 gene should be evaluated as
CMT causing variants in the Vietnamese population , predominantly axonal form of
neuropathy in
CMT disease . -
pubmed
Overexpression of LncRNA
GHET1 predicts an unfavourable survival and clinical parameters of
patients in various
cancers . -
pubmed
Recently , increasing studies have reported that long non - coding RNA ( lncRNA ) gastric
carcinoma highly expressed transcript 1 (
GHET1 ) is highly expressed in variety of
cancers and relevant to poor prognosis of
cancer patients . -
pubmed
Nevertheless , the results were inconsistent and the systematic analysis of lncRNA
GHET1 in
cancers has not been inspected . -
pubmed
Thus , we aim to evaluate the relationship between lncRNA
GHET1 expression and clinical outcomes in human
cancers . -
pubmed
The pooled results of this study indicated that high lncRNA
GHET1 expression level was significantly associated with poor overall survival ( OS , HR = 2.30 , 95 % CI : 1.75 - 3.02 ) in
human cancers . -
pubmed
In addition , the elevated lncRNA
GHET1 expression was also significantly related to more advanced clinical stage , earlier lymph node metastasis , earlier distant metastasis and bigger
tumour size . -
pubmed
LncRNA
GHET1 may serve as a promising biomarker for prognosis in Asians with
cancers . -
pubmed
We further found that
luteolin supplementation protected
mice from
insulin resistance induced by HFD consumption ; this improved
insulin resistance was correlated with reductions in CD11c+ adipose tissue macrophages . -
pubmed
Cohesin - dependent regulation of gene expression during differentiation is lost in Cohesin - mutated
myeloid malignancies . -
pubmed
Cohesin complex disruption alters gene expression and
Cohesin mutations are common in
myeloid neoplasia , suggesting a critical role in hematopoiesis . -
pubmed
Together with corroborative findings in
acute myeloid leukemia and
myelodysplastic syndrome patient samples , these data suggest
Cohesin - mediated alleviation of
Etv6 repression is required for dynamic expression at critical erythroid genes during differentiation and how this may be perturbed in
myeloid malignancies . -
pubmed
Correction to : Serum exosomal -
annexin A2 is associated with African - American triple - negative
breast cancer and promotes angiogenesis . -
pubmed
Prognostic role of
alpha - fetoprotein in
patients with
hepatocellular carcinoma treated with repeat transarterial chemoembolisation . -
pubmed
CONCLUSION :
Serum AFP level following initial treatment in
patients undergoing repeat TACE for
HCC is a simple and useful clinical prognostic marker . -
pubmed
We tested how adjuvants effect in a
cancer vaccine model using an epitope derived from an autoactivation loop of
membrane - type protease serine protease 14 (
PRSS14 ; loop metavaccine ) in
mouse mammary tumor virus (
MMTV)-polyoma middle tumor - antigen ( PyMT ) system and in 2 other orthotopic
mouse systems . -
pubmed
Survival analysis of
breast cancer patients showed that eosinophil
chemokines can be useful prognostic factors in
PRSS14 positive
patients . -
pubmed
These data suggest that
melatonin may be a useful therapeutic agent to reduce
cocaine abuse ; additionally , they suggest that
MT1 and
MT2 receptors could be therapeutic targets , useful for the treatment of
drug abuse disorder . -
pubmed
microRNA-383 suppresses the
PI3K -
AKT -
MTOR signaling pathway to inhibit development of
cervical cancer via downregulating
PARP2 , " by Peng Teng , Yan Jiao , Min Hao , Xin Tang , J Cell Biochem . -
pubmed
High antibody levels to the mycobacterial
fibronectin - binding antigen of 30 - 31 kD in
tuberculosis and
lepromatous leprosy . -
pubmed
Immunoblot assays showed that mycobacterial
fibronectin - binding antigens are important targets of the humoral immune response in
tuberculosis and
leprosy . -
pubmed
Using culture filtrate antigens of
Mycobacterium tuberculosis , strong reactivity with the
fibronectin - binding of 30 - 31 kD ( Fn 30 - 31 ) was demonstrated in 55.9 % of
tuberculosis sera and in 56.5 % of
lepromatous leprosy sera . -
pubmed
Reactivity of
tuberculosis and
lepromatous leprosy sera with the
fibronectin - binding antigen of 58 - 60 kD (
Fn 58 - 60 ) was less conspicuous . -
pubmed
tuberculosis
Fn 30 - 31 , which elicits a high antibody response in
lepromatous leprosy but not in
tuberculoid leprosy . -
pubmed
Histology revealed a continuous spectrum in which '
gliosarcomas ' with large reticulin - rich areas of spindle cells merged with typical
glioblastomas containing only small islands of spindle cells and
reticulin staining . -
pubmed
Immunocytochemistry for
glial fibrillary acidic protein (
GFAP ) ;
S100 protein and
alpha - smooth muscle actin (
ASMA ) showed that the majority of cells in
reticulin - poor areas of '
gliosarcoma ' and
glioblastomas expressed
S100 protein and
GFAP ; many expressed
ASMA and some expressed both
GFAP and
ASMA . -
pubmed
Spindle cells in reticulin - rich areas of '
gliosarcomas ' and
glioblastomas most frequently expressed
ASMA but many cells also expressed
S100 protein and
GFAP ; some cells expressed both
GFAP and
ASMA . -
pubmed
In the 48 - h exposure test , the
cytotoxic effect of
MGb2 - MMC upon target cells was similar to that of free
MMC , but much greater than that of normal
mouse immunoglobulin -
MMC conjugate . -
pubmed
When we treated the monolayers with drugs commonly used for the treatment of
inflammatory bowel disease , including
prednisolone ,
5 - aminosalicylic acid ,
metronidazole , and
6 - mercaptopurine , we were not able to demonstrate a reduction in carrageenan - induced cell injury ; however ,
catalase at 1 mg / ml decreased carrageenan
cytotoxicity . -
pubmed
Drugs commonly used to treat
inflammatory bowel disease do not inhibit carrageenan injury in this cell model system , although
catalase does decrease injury . -
pubmed
Cushing ' s syndrome , caused by ectopic
ACTH production during
Zollinger - Ellison syndrome , raises difficult therapeutic problems . -
pubmed
In a short term study with 200 micrograms
SMS bid , symptoms of
hypercorticism disappeared while
cortisol and
ACTH serum concentrations fell below the normal values . -
pubmed
Ganglionic , spinal cord and hypothalamic
atrial natriuretic factor : its distribution , origin and possible role in spontaneously
hypertensive rats . -
pubmed
In spontaneously
hypertensive rats ( SHR ) we found an elevated
ANF - C content in all tissues along the pathway of increased efferent sympathetic outflow , which is present in this
animal model . -
pubmed
Prognostic value of
CEA and
ferritin assay in
breast cancer : a multivariate analysis . -
pubmed
The prognostic significance of preoperative serum
carcinoembryonic antigen (
CEA ) and
ferritin levels was evaluated in 191
women operated for
breast cancer . -
pubmed
Axillary node status ( P = 0.004 ) ,
CEA level ( P = 0.011 ) , and the histological grade of the
tumor ( P = 0.029 ) emerged as independent prognostic factors . -
pubmed
By contrast , no significant relationship was found between
ferritin and
disease - free survival . -
pubmed
The data showed that the prognosis of
patients with different combinations of node status and
tumor grade was related to the level of
CEA . -
pubmed
Only
women with very good ( node - negative with well - differentiated
tumors ) or very bad prognosis ( node - positive with four or more metastatic nodes and poorly differentiated
tumors ) had a
disease - free survival independent of
CEA values . -
pubmed
The chemical carcinogen - induced enzyme ,
GDP - fucose :
GM1 alpha 1 - --- 2 fucosyltransferase in
rat liver and
hepatoma : modulation by and association with
phospholipids . -
pubmed
active and passive light physical activity ) on the plasmatic
cholesterol ,
HDL -
cholesterol ,
triglycerides contents and on
beta / alpha lipoproteins ratio as well in a group of 62
patients ( 39
males and 23 females ) with
neuromotor lesions are reported . -
pubmed
Intracerebroventricular injection of ostrich
beta - endorphin to satiated
pigeons induces
hyperphagia but not
hyperdipsia . -
pubmed
Evaluation of
prostate specific acid phosphatase and
prostate specific antigen in identification of
prostatic cancer . -
pubmed
The peroxidase - anti -
peroxidase technique was used to stain for
prostate specific acid phosphatase and
prostate specific antigen in 12
patients with primary
tumors and in 12
patients with metastases in whom the nature of the
tumor was in doubt after routine histopathological studies . -
pubmed
Nine of the primary
tumors were positive for both markers and an additional 2
tumors stained for
prostate specific antigen only . -
pubmed
The heterogeneity of the
tumors in regard to these 2 prostate markers is demonstrated , and the value of staining for
prostate specific acid phosphatase and
prostate specific antigen is emphasized . -
pubmed
We therefore urge careful examination to detect
amyloid deposits of all kidney biopsy specimens of minor
glomerular abnormalities , or
glomerulonephritis with
IgA deposits from elderly
patients with
nephrotic syndrome . -
pubmed
Immunohistochemically , the
tumor cells demonstrated positive reactivity for high molecular weight
keratin and glandular lumina membrane positivity for
EMA , which support a collecting duct origin for the
tumor . -
pubmed
Histological difference between complete responders and non - responders to
interferon therapy of the livers of
patients with
chronic hepatitis C. -
pubmed
Liver histology was compared in
patients with
chronic hepatitis C to note the differences between responders and non - responders to
interferon treatment . -
pubmed
Nicotinic and muscarinic receptors have been visualized in normal and
AD brains . -
pubmed
When an
AD patient with moderate
dementia was treated with
nerve growth factor (
NGF ) PET studies revealed increase in cortical blood flow and
nicotinic receptors . -
pubmed
A point mutation in the
bile acid biosynthetic enzyme
sterol 27 - hydroxylase in a family with
cerebrotendinous xanthomatosis . -
pubmed
An examination was made of the cDNA encoding
cytochrome P450 sterol 27 - hydroxylase (
CYP27 ) in hepatic mitochondria , considered a defective enzyme inducing
CTX , in a Japanese housewife afflicted with
CTX and her family . -
pubmed
The proposita and one of her brothers , who also had
CTX symptoms and
hypercholestanolemia , were found to be homozygotic , carrying a point mutation in the
CYP27 gene at Arg104 ( CGG ) to Trp104 ( TGG ) . -
pubmed
An increase in plasma
cholestanol alone would , thus , not appear to be a direct cause of
sterol storage in
CTX , while CTX is strongly suggested to be caused by defects in both alleles of the
CYP27 gene . -
pubmed
From the sera of
patients with advanced
cancer , a novel factor called
SDF (
serum - derived factor ) was partially purified . -
pubmed
We concluded that
SDF might be a novel factor associated with the clinical features of advanced
cancer . -
pubmed
It is speculated that
SDF might have some role in disease progression of
AIDS as well as in the development of the
cachectic conditions in
AIDS associated with
malignancies . -
pubmed
PC3 (
pheochromocytoma cell-3 ) is an immediate early gene isolated as sequence induced in the
rat PC12 cell line during neuronal differentiation by
nerve growth factor (
NGF ) . -
pubmed
In stable
NIH3T3 clones expressing
PC3 , the transition from G1 to S phase was impaired , whereas the
retinoblastoma (
RB ) protein was detected as multiple isoforms of M(r ) 105,000 - 115,000 ( indicative of a hyperphosphorylated state ) only in low - density cultures . -
pubmed
Systemic
vasopressin ( V1 ) receptor blockade did not inhibit the pressor response , and
rats with
central diabetes insipidus ( DI / DI ) displayed an identical rise in MAP . -
pubmed
CR1 density polymorphism and expression on erythrocytes of patients with
systemic lupus erythematosus . -
pubmed
The present study investigated the expressed number of
CR1 on erythrocytes ( E ) in relationship of the
CR1 density genotype from 46 patients with
systemic lupus erythematosus (
SLE ) and 47 healthy volunteers . -
pubmed
Our data supported the earlier results that the number of binding sites / E for monoclonal anti -
CR1 decreased among
SLE patients compared with normal individuals having the same alleles for the
CR1 / E density . -
pubmed
At the same time the novelty of our recent results was that the decreased expression of
CR1 on E correlated significantly with
kidney involvement in patients homozygous for the
CR1 / E high density allele ( HH ) . -
pubmed
These data suggest that the deficiency of the detectable number of
CR1 on erythrocytes is acquired in this
SLE population . -
pubmed
We reviewed here that protein isomerization is enhanced in
amyloid - beta peptides (
Abeta ) and paired helical filaments ( PHFs ) purified from
Alzheimer ' s disease (
AD ) brains . -
pubmed
We show here that
PIMT is upregulated in neurodegenerative neurons and colocalizes in neurofibrillary tangles ( NFTs ) in
AD . -
pubmed
Taken together with the enhanced protein isomerization in
AD brains , it is implicated that the upregulated
PIMT may associate with increased protein isomerization in
AD . -
pubmed
We also reviewed studies on
PIMT - deficient mice that confirmed that
PIMT plays a physiological role in the repair of isomerized proteins containing
L - isoaspartate . -
pubmed
p53 tumor suppressor is a subject of several post - translational modifications , including phosphorylation , ubiquitination and acetylation , which regulate
p53 function . -
pubmed
[ Expression of
ICAM-1 /
LFA-1 in the pocket area of adult
periodontitis ] . -
pubmed
OBJECTIVE : To study the expression of
ICAM-1 /
LFA-1 in the pocket area of adult
periodontitis . -
pubmed
METHODS : Expressions of
ICAM-1 /
LFA-1 in adult gingival of
periodontitis and healthy subjects were studied by
alkaline phosphorylase -
antialkaline phosphorylase technique . -
pubmed
RESULTS : Junctional epithelium and apical part of sulcus epithelium expressed
ICAM-1 in both adult
periodontitis and healthy gingiva , showing an
ICAM-1 gradient change with maximal staining at tooth aspect and weaker staining in the basal layer of keratinocytes . -
pubmed
Significantly more
LFA-1 positive leukocytes were observed in connective tissues and within pocket epithelium in adult
periodontitis than those in healthy gingiva . -
pubmed
CONCLUSION :
ICAM-1 /
LFA-1 may provide important adhesion pathway for leukocytes migration into gingiva sulcus in adult
periodontitis lesions . -
pubmed
Forty - six percent were
ER positive ( median , 16 fmol / mg protein ; range , 5 - 1017 fmol / mg ) , and 35 % were
PgR positive ( median , 61 fmol / mg protein ; range , 6 - 854 fmol / mg ) . -
pubmed
CONCLUSIONS : We underscore the utility of combined cavernous lavage + adjuvant
alpha-1 adrenergic agonist as initial therapy in
priapism with this special etiology . -
pubmed
The expression of the proteins
ERBB2 ,
JUN ,
RAS and
tissue factor was significantly higher in
adenocarcinomas compared to
squamous cell lung carcinomas . -
pubmed
In contrast , all resistance proteins analyzed were more frequently expressed in
squamous cell lung carcinomas in comparison to
adenocarcinomas , though only
GST - pi reached statistical significance . -
pubmed
These methods provide valuable tools to forward our understanding of the role of
NF - kappaB in plasticity as well as in many
neurological disorders being mimicked by in vitro studies . -
pubmed
The aim of this study was to evaluate the relationship between the rate of
fibrosis progression and the sustained virologic response ( SVR ) to
interferon (
IFN)-based treatment . -
pubmed
Hence the rate of
fibrosis progression is an independent predictor of SVR to
IFN - based therapy in patients with
chronic hepatitis C. -
pubmed
Anti -
thrombin , anti - platelet and anti -
vitamin K agents are common treatments given for the prevention of
thrombotic or embolic events . -
pubmed
The lack of
suppressor of cytokine signalling-1 (
SOCS1 ) protects
mice from the development of
cerebral malaria caused by Plasmodium berghei ANKA . -
pubmed
Cerebral malaria is a severe complication of infection with
Plasmodium berghei ANKA involving the
Th1 cytokines TNF - alpha and
IFN - gamma . -
pubmed
Contrary to the expectation that
SOCS1 - deficient
mice , in which
IFN - gamma responses are uncontrolled and which are more sensitive to
IFN - gamma , may show heightened susceptibility ,
mice lacking
SOCS1 were protected from
cerebral malaria . -
pubmed
Unlike the controls and despite similar
parasitaemia , infected
SOCS1 null
mice showed no
inflammation or
haemorrhaging in the brains . -
pubmed
Mice lacking
SOCS1 exhibited decreased splenic cellularity and a reduced ratio of
CD4 :
CD8 lymphocytes , which were maintained during
infection . -
pubmed
However , the ratio of
IFN - gamma to IL-4 mRNA expression during
infection was similar in
SOCS1 -/- and control
mice suggesting that a dramatic shift in the ratio of Th1 : Th2 responses does not account for the resistance to disease . -
pubmed
Understanding the mechanism by which
SOCS1 deficiency protects
mice from
cerebral malaria may allow the manipulation of its activity and alleviate pathology . -
pubmed
HORTON ' S SYNDROME , A
GENETIC DISEASE : The preferential association of the disease with some alleles pf the
HLA DR4 group has helped to emphasize the fundamental role of a few
amino acids of the second hypervariable area of the
HLA - DR molecule . -
pubmed
Moreover ,
intimal hyperplasia ( mediated by the
PDGF (
platelet derived growth factor ) A and B ) and
thrombosis ( related to the
inflammation ) join up in reducing the arterial flow and enhancing the risk of
ischemic complications during the acute stage . -
pubmed
PATHOGENESIS , HYPOTHESES : Various candidate - antigens have been incriminated in the onset of the inflammatory reaction during
Horton ' s syndrome . -
pubmed
p53 immunostaining pattern in Brazilian
patients with
hepatocellular carcinoma . -
pubmed
The
tumor suppressor gene
p53 is mutated in highly variable levels ( 0 - 52 % ) of
HCC in different countries . -
pubmed
OBJECTIVE : The objective of the present study was to compare the frequency of aberrant immunohistochemical expression of
p53 in
HCC occurring in
cirrhotic or in non - cirrhotic
patients as well as in
liver cell dysplasia and in
adenomatous hyperplasia . -
pubmed
Nontumorous areas either in the vicinity of
HCC or in the 30 purely
cirrhotic cases showed no nuclear
p53 altered expression , even in foci of
dysplasia or
adenomatous hyperplasia . -
pubmed
CONCLUSION : The therapeutic effect of JGG in treating
postmenopausal osteoporosis might be related with its regulation on the two kinds of protein ,
RHAMM and
ATP1b3 . -
pubmed
Nuclear factor - kappaB activation correlates with better prognosis and
Akt activation in
human gastric cancer . -
pubmed
PURPOSE : Because the biological significance of constitutive
nuclear factor - kappaB (
NF - kappaB ) activation in
human gastric cancer is unclear , we undertook this study to clarify the regulatory mechanism of
NF - kappaB activation and its clinical significance . -
pubmed
EXPERIMENTAL DESIGN : Immunohistochemistry for
NF - kappaB /
RelA was done on 290
human gastric
carcinoma specimens placed on tissue array slides . -
pubmed
The correlations between
NF - kappaB activation and clinicopathologic features , prognosis ,
Akt activation ,
tumor suppressor gene expression , or
Bcl-2 expression were analyzed . -
pubmed
We also did luciferase reporter assay , Western blot analysis , and reverse transcription - PCR using the
SNU-216 human gastric cancer cell line transduced with retroviral vectors containing constitutively active
Akt or the
NF - kappaB repressor mutant of
IkappaBalpha . -
pubmed
RESULTS : Nuclear expression of
RelA was found in 18 % of the gastric
carcinomas and was higher in early - stage pathologic
tumor - node - metastasis ( P = 0.019 ) . -
pubmed
A negative correlation was observed between
NF - kappaB activation and lymphatic invasion ( P = 0.034 ) and a positive correlation between
NF - kappaB activation and overall survival rate of
gastric cancer patients ( P = 0.0228 ) . -
pubmed
In addition ,
NF - kappaB activation was positively correlated with
pAkt ( P = 0.047 ) ,
p16 ( P = 0.004 ) ,
adenomatous polyposis coli ( P & lt ; 0.001 ) ,
Smad4 ( P = 0.002 ) , and
kangai 1 ( P & lt ; 0.001 ) expression . -
pubmed
An in vitro study showed that
NF - kappaB activity in
gastric cancer cells is controlled by and controls
Akt . -
pubmed
CONCLUSIONS :
NF - kappaB activation was frequently observed in early - stage
gastric carcinoma and was significantly correlated with better prognosis and
Akt activation . -
pubmed
These findings suggest that
NF - kappaB activation is a valuable prognostic variable in
gastric carcinoma . -
pubmed
In vitro , inhibition of
NTE activity by
organophosphates is correlated with inhibition of neurite initiation and reduction of neurite length , supporting the hypothesis that
organophosphate - induced
neurological disorders are caused by inhibition of
NTE activity . -
pubmed
However , there is no direct evidence for the involvement of
NTE in
organophosphate - induced
impairment of neurites in vitro . -
pubmed
Selective inhibitors of the
cyclooxygenase-2 enzyme were developed to treat
pain and
inflammation while reducing the risk of the serious gastrointestinal side effects seen with nonselective nonsteroidal anti - inflammatory drugs ( NSAIDs ) . -
pubmed
Heme deficiency is associated with senescence and causes suppression of
N - methyl - D - aspartate receptor subunits expression in primary cortical neurons . -
pubmed
BNP as a marker of the
heart failure in the treatment of
imatinib mesylate . -
pubmed
Since its introduction 6 years ago ,
imatinib mesylate , a selective
tyrosine kinase inhibitor , has been a phenomenon in treating
chronic myelogenous leukemia (
CML ) with remarkably superior cytogenetic and molecular response rates at all stages of
CML followed by longer progression free survival . -
pubmed
Here we , for the first time , report development of
heart failure in
patients on
imatinib mesylate medication and the possibility of
brain natriuretic peptide (
BNP ) as a potential diagnostic ( or predicting ) marker for
heart failure . -
pubmed
Since plasma
BNP levels in the two
patients were exceptionally high , we then explored the possibility of genetic association of
BNP with the development of
heart failure to find no positive association . -
pubmed
Bilateral risk - reducing oophorectomy ( BRRO ) is widely used for
cancer risk reduction in women with
BRCA1 and
BRCA2 (
BRCA1 / 2 ) mutations . -
pubmed
A genome - wide scan identifies mutations in the gene encoding
phosphodiesterase 11A4 (
PDE11A ) in
individuals with
adrenocortical hyperplasia . -
pubmed
Increased
cyclic AMP (
cAMP ) signaling has been associated with
PRKAR1A or
GNAS mutations and leads to
adrenocortical tumors and
Cushing syndrome . -
pubmed
Tumor tissues showed 2q31 - 2q35 LOH , decreased protein expression and high
cyclic nucleotide levels and
cAMP - responsive element binding protein (
CREB ) phosphorylation . -
pubmed
PDE11A codes for a dual - specificity
PDE that is expressed in adrenal cortex and is partially inhibited by
tadalafil and other
PDE inhibitors ; its germline inactivation is associated with
adrenocortical hyperplasia , suggesting another means by which dysregulation of
cAMP signaling causes
endocrine tumors . -
pubmed
Specific
caspase inhibitor
Q - VD - OPh prevents
neonatal stroke in P7
rat : a role for gender . -
pubmed
In the present study , a third generation dipeptidyl broad - spectrum
caspase inhibitor ,
quinoline - Val - Asp ( Ome )- CH2 - O - phenoxy (
Q - VD - OPh ) , was tested in a model of unilateral focal
ischaemia with reperfusion in 7 - day - old
rats . -
pubmed
Following
ischaemia in P7
rats , males and females displayed different time course and pattern of
cytochrome c release and active
p17 caspase 3 during the first 24 h of recovery . -
pubmed
Effects of
ERBB2 amplicon size and genomic alterations of chromosomes 1 , 3 , and 10 on patient response to trastuzumab in metastatic
breast cancer . -
pubmed
Trastuzumab is widely used for advanced
breast cancer patients with
ERBB2 - amplified
tumors . -
pubmed
In 35 patients with
ERBB2 - amplified metastatic
breast cancer , with 40 % overall response to trastuzumab , fluorescence in situ hybridization identified the telomeric extent of the
ERBB2 amplicon and the status of the several pathway - related genes . -
pubmed
However , the molecular mechanisms by which
PP2A activity is inhibited in
human cancers are currently unclear . -
pubmed
In addition to its function in
c - Myc stabilization ,
CIP2A promotes anchorage - independent cell growth and in vivo
tumor formation . -
pubmed
Importantly ,
CIP2A is overexpressed in two common
human malignancies ,
head and neck squamous cell carcinoma (
HNSCC ) and
colon cancer . -
pubmed
Thus , our data show that
CIP2A is a
human oncoprotein that inhibits
PP2A and stabilizes
c - Myc in
human malignancies . -
pubmed
Association study of the
brain - derived neurotropic factor (
BDNF ) gene in
attention deficit hyperactivity disorder . -
pubmed
Brain - derived neurotropic factor (
BDNF ) has been suggested to play a role in the pathogenesis of
ADHD and two family - based association studies demonstrated an association of
BDNF polymorphisms with
ADHD . -
pubmed
The aim of the current study was to investigate the
BDNF gene for association with
ADHD in a large sample of families from Toronto . -
pubmed
The transmission of three polymorphisms of the
BDNF gene ( rs6265 , rs11030104 , and rs2049046 ) was examined in 266 nuclear families ascertained through a proband with
ADHD ( 315 affected children ) using the transmission / disequilibrium test ( TDT ) . -
pubmed
In light of the evidence for an involvement of
BDNF in
ADHD , further analysis of the
BDNF gene in
ADHD is warranted . -
pubmed
METHODS : We collected and prepared sera of
cervical carcinoma from Uighur women , and separated and processed data using 2 - dimensional liquid phase chromatography system specific for
protein ( ProteomeLab PF-2D ) . -
pubmed
STAT3 inhibitor
WP1066 as a novel therapeutic agent for
renal cell carcinoma . -
pubmed
BACKGROUND :
Signal transducer and activator of transcription 3 (
STAT3 ) regulates the expression of genes that mediate cell survival , proliferation , and angiogenesis and is aberrantly activated in various types of
malignancies , including
renal cell carcinoma (
RCC ) . -
pubmed
We examined whether it could be a novel therapeutic target for
RCC by using the
STAT3 inhibitor
WP1066 . -
pubmed
RESULTS : In
Caki-1 and
786 - O renal cancer cells , 5 muM
WP1066 prevented the phosphorylation of
STAT3 , and 2.5 muM
WP1066 significantly ( P<0.01 ) inhibited cell survival and proliferation . -
pubmed
WP1066 suppressed the expression of
Bcl-2 , induced apoptosis , and inhibited the basal and
hypoxia - induced expression of
HIF1alpha and
HIF2alpha , as well as
vascular endothelial growth factor secretion into cell culture medium . -
pubmed
Systemic oral administration of
WP1066 to
mice for 19 days significantly inhibited the growth of
Caki-1 xenograft
tumours ( P<0.05 ) , and pathological analysis of xenografts of
WP1066 - treated
mice showed decreased immunostaining of phosphorylated
STAT3 and reduced length of
CD34 - positive vessels ( P<0.05 ) . -
pubmed
CONCLUSION : Our results suggest that using
WP1066 to inhibit the
STAT3 signalling pathway could be a novel therapeutic strategy against
RCC . -
pubmed
Toll - like receptor 4 stimulation triggers crescentic
glomerulonephritis by multiple mechanisms including a direct effect on renal cells . -
pubmed
A role for
toll - like receptor 4 (
TLR4 ) has been suggested in previous studies of
glomerulonephritis , but the complex integration of these effects has not been explored . -
pubmed
These findings , in a single disease model , illustrate that
TLR4 stimulation triggers crescentic
glomerulonephritis by effects on both the adaptive and innate immune response , with a crucial direct effect on renal cells . -
pubmed
Myocardial infarction leads to structural remodeling of the myocardium , in particular to the loss of cardiomyocytes due to
necrosis and an increase in
collagen with scar formation . -
pubmed
Hirame natural embryo ( HINAE ) cells overexpressing
MDA5 showed a lower cytopathic effect ( CPE ) against
VHSV , hirame rhabdovirus (
HIRRV ) and
infectious pancreatic necrosis virus ( IPNV ) infection . -
pubmed
Bz-423 , a small - molecule inhibitor of the
mitochondrial F ( 1 ) F ( 0 ) adenosine triphosphate synthase ( F ( 1 ) F ( 0 )- ATPase ) , selectively increased
superoxide and induced the apoptosis of alloreactive T cells , which arrested established
GVHD in several
BMT models without affecting hematopoietic engraftment or lymphocyte reconstitution . -
pubmed
NACP - Rep1 relates to Beck
Depression Inventory scores in healthy
humans . -
pubmed
Alpha - synuclein (
SNCA ) is associated with a range of
psychiatric diseases including
neurodegeneration ,
alcohol craving , and
depression . -
pubmed
To date , it is unclear whether the previously described association between
SNCA and
depressive symptomatology is limited to females with
eating disorders or whether it could be extended to include healthy
individuals . -
pubmed
BACKGROUND AND PURPOSE : The
cystic fibrosis transmembrane conductance regulator (
CFTR ) is a
cAMP - dependent
chloride channel in the plasma membrane of epithelia whose mutation is the cause of the
genetic disease cystic fibrosis (
CF ) . -
pubmed
[ Effects of
valproate sodium on
pituitary gonadotropin in adolescent
girls with
epilepsy ] . -
pubmed
OBJECTIVE : To study the effects of
valproate sodium (
VPA ) on the level and axle of
pituitary gonadotropin in adolescent
girls with
epilepsy . -
pubmed
RESULTS : The serum levels of
estradiol ,
follicle - stimulating hormone ,
luteinizing hormone and
prolactin in the
children with
epilepsy were not significantly different during the 1 year
VPA treatment compared with pretreatment . -
pubmed
Remarkable reduction of
MAP2 in the brains of scrapie - infected
rodents and
human prion disease possibly correlated with the increase of calpain . -
pubmed
To obtain insight into the possible alteration and the role of
MAP2 in
transmissible spongiform encephalopathies (
TSEs ) , the
MAP2 levels in the brain tissues of agent 263K - infected
hamsters and
human prion diseases were evaluated . -
pubmed
Western blots and IHC revealed that at the terminal stages of the diseases ,
MAP2 levels in the brain tissues of scrapie infected
hamsters , a
patient with genetic
Creutzfeldt - Jakob disease ( G114V
gCJD ) and a
patient with fatal
familial insomnia (
FFI ) were almost undetectable . -
pubmed
Our data indicate that the decline of
MAP2 is a common phenomenon in
TSEs , which seems to occur at an early stage of incubation period . -
pubmed
The activity of these compounds on
seizure control is independent of
histone deacetylase inhibitory activity ( associated with the teratogenicity of
VPA ) , and does not correlate with
liver cell toxicity . -
pubmed
The effect of copy number variation in the phase II detoxification genes
UGT2B17 and
UGT2B28 on
colorectal cancer risk . -
pubmed
Metabolizers of environmental carcinogenic and endogenous compounds affecting
CRC risk include the phase II detoxification
UDP - glucuronosyltransferase (
UGT ) enzymes
UGT2B17 and
UGT2B28 , which are 2 of the most commonly deleted genes in the genome . -
pubmed
METHODS : To study the effect of
UGT2B17 and
UGT2B28 copy number variation ( CNV ) on
CRC risk , 665 Caucasian
CRC cases and 621 Caucasian controls were genotyped who had completed extensive demographics and lifestyle questionnaires . -
pubmed
RESULTS : A significant association between the
UGT2B17 deletion genotype ( 0/0 ) and decreased
CRC risk was found when the entire population was analyzed ( P = .044 ) . -
pubmed
A significant association between
UGT2B17 ( 0/0 ) and decreased risk for rectal ( P = .0065 ) but not
colon cancer was found . -
pubmed
No significant association was found between
UGT2B28 CNV and
CRC risk . -
pubmed
CONCLUSIONS : The
UGT2B17 deletion genotype ( 0/0 ) was associated with a decreased
CRC risk in a Caucasian population . -
pubmed
Crescentic
glomerulonephritis due to
IgA nephropathy or
propylthiouracil - induced
Mpo - Anca positive
vasculitis ? -
pubmed
AIM :
beta - Adrenoceptor blockers have been used with caution in
patients with
obstructive lung diseases such as
asthma or
chronic obstructive pulmonary disease (
COPD ) , due to the potentially increased airway reactivity and risk of
bronchial obstruction . -
pubmed
Cardioselective
beta - adrenoceptor blockers have a more beneficial profile than non - cardioselective
beta - adrenoceptor blockers and can be safely prescribed to
patients with both
cardiovascular disease and
COPD . -
pubmed
After exclusion of
patients with
COPD ,
asthma and
heart failure the effects of cardioselective
beta - adrenoceptor blockers remained significant for FEV1 ( -142 ml [ 95 % CI -189 , -96 ] ) and for FVC ( -176 ml [ 95 % CI -236 , -117 ] ) . -
pubmed
Prospective validation of quantitative
NSE mRNA in pleural fluid of
non - small cell lung cancer patients . -
pubmed
Based on a retrospective study of 86 curatively resected
lung cancer patients ( training set ) , we determined a cutoff value of
NSE mRNA using receiver - operating characteristic curve . -
pubmed
CONCLUSIONS : Notably , the influenza
hemagglutinin (
HA ) receptor has evolutionary conserved domains that can serve as basis for the rational design of a universal
influenza vaccine . -
pubmed
Neuroglobin is a brain globin with neuroprotective effects against
ischemia and related pathological processes , acting as
O2 sensor and antiapoptotic pathway transducer . -
pubmed
Glial fibrillary acidic protein (
GFAP ) was increased whereas
spinophilin and postsynaptic density ( PSD)-95 protein were decreased in the CA1 of
depressed monkeys . -
pubmed
Gene expression of
GFAP paralleled the protein changes observed in the CA1 and was inversely related to serum
estradiol levels in
depressed monkeys . -
pubmed
CONCLUSIONS : A therapeutic window for the clinical investigation of
LY2157299 in
cancer patients was defined using a targeted
PK / PD approach , which integrated translational biomarkers and
preclinical toxicity . -
pubmed
beta ( 2 )- Adrenoreceptor blockade improves early posttrauma
hyperglycemia and
pulmonary injury in
obese rats . -
pubmed
Insulin is widely used to control posttrauma
glucose , but this treatment increases the risk of
hypoglycemia . -
pubmed
We tested a novel method for early posttrauma
hyperglycemia control by suppressing hepatic glycogenolysis via
beta2 - adrenoreceptor blockade [
ICI-118551 ( ICI ) ] . -
pubmed
One day after
trauma , plasma
IL-6 levels , lung neutrophil numbers ,
myeloperoxidase (
MPO ) activity , and wet - to - dry weight ratios were measured . -
pubmed
ICI treatment reduced the early
hyperglycemia , lung neutrophil retention ,
MPO activity , and wet - to - dry weight ratio in OZ
rats to levels comparable with those seen in LZ
rats , with no effect on blood pressure or heart rate . -
pubmed
These results demonstrate that
beta2 - adrenoreceptor blockade effectively reduces the early posttrauma
hyperglycemia , which is associated with decreased
lung injury in OZ
rats . -
pubmed
Invited commentary on " Evaluation of a predictive model for
pancreatic fistula based on
amylase value in drains after pancreatic resection " by Partelli et al . -
pubmed
Adenosine A2A - D2 receptor - receptor interactions in putative heteromers in the regulation of the striato - pallidal gaba pathway : possible relevance for
parkinson ' s disease and its treatment . -
pubmed
In fact , the existence of putative
striatalA2A / D2 receptor heteromers has been suggested to be important for striatal function under both normal and pathological conditions , such as
Parkinson ' s disease . -
pubmed
Consequently , the antagonistic
A2A - D2 receptor interactions in a putative striatal receptor heteromer on striato - pallidal
GABA neuron led to the introduction of
A2A receptor antagonists as possible anti-
Parkinsonian drugs . -
pubmed
The possible relevance of compounds targeting the putative striatal
A2A /
D2 heteromer in the
Parkinson ' s disease pharmacological treatment is also discussed . -
pubmed
Can
TIE-2 expressing monocytes represent a novel marker for
hepatocellular carcinoma ? -
pubmed
Mechanisms of
tumor necrosis factor alpha antagonist - induced
lupus in a
murine model . -
pubmed
OBJECTIVE :
Tumor necrosis factor alpha (
TNFalpha ) antagonists are effective for treating
rheumatoid arthritis and other
inflammatory diseases , but their use can be complicated by the development of
lupus - like phenomena . -
pubmed
METHODS :
Toll - like receptor 7 (
TLR-7 ) ligand - driven
lupus was induced by injection of
pristane into
C57BL / 6 ( B6 ) mice deficient in
TNFalpha (
TNFalpha(-/- ) ) or
TNFalpha - intact B6
mice as wild - type controls . -
pubmed
When treated with
pristane ,
TNFalpha(-/- )
mice developed more severe
lupus compared to
pristane - treated controls , characterized by increased levels of anti - Sm / RNP autoantibodies ,
type I IFN , PDCs , and peritoneal inflammatory ( Ly-6C(high ) ) monocytes . -
pubmed
In pristane - treated
TNFalpha(-/- )
mice , the numbers of neutrophils , a cell type that promotes resolution of
inflammation , were decreased considerably , whereas the responses of inflammatory monocytes and PDCs and the production of
type I IFN were increased and prolonged . -
pubmed
In
humans , the rate of clearance of dead cells , along with the levels of
TNFalpha , may influence who will develop
lupus following treatment with
TNFalpha inhibitors . -
pubmed
In cluster 3 , transcription factor
ESR1 was reported related with
hepatocellular carcinoma . -
pubmed
As a pre - metastatic niche rich in a variety of
chemokines , the BM niche is turned into a locus of
tumor cell development and division . -
pubmed
Knowledge of
chemokines and their receptors leads to the production of various therapeutic antagonists at
chemokine receptors expressed on leukemic and
tumor cells , enabling interference with
chemokine function as a therapeutic tool . -
pubmed
DDAH is an enzyme that metabolizes
asymmetric dimethylarginine (
ADMA ) , an endogenous inhibitor of
NO synthesis , previously shown to be elevated in the plasma of pre -
eclamptic mothers . -
pubmed
Both dysregulation of
DDAH and the accumulation of
ADMA have been associated with the development of
pre - eclampsia . -
pubmed
This is the first study to implicate the
DDAH /
ADMA pathway as a mechanism that might underlie the poor trophoblast invasion seen in this common
pregnancy disorder . -
pubmed
Carney triad is distinct from the dyad of
paragangliomas /
pheochromocytomas and
gastrointestinal stromal tumors , known as
Carney - Stratakis syndrome , which is inherited in an autosomal- dominant manner and is almost always caused by
succinate dehydrogenase subunit mutations . -
pubmed
A patient with
Carney triad and
SDHC variant had a
ganglioneuroma . -
pubmed
One of the patients with
Carney triad and
SDHB mutation had a nephew with the same sequence defect , who developed a
neuroblastoma . -
pubmed
Other relatives , carriers of the identified
SDHA ,
SDHB or
SDHC mutations , have not developed any of the components of
Carney triad or
Carney - Stratakis syndrome . -
pubmed
None of the other 57
Carney triad patients had any genomic defects of
SDHA ,
SDHB or
SDHC genes . -
pubmed
Although for the vast majority of patients with
Carney triad the causative defect(s ) remain(s ) unknown , testing for
SDHA ,
SDHB or
SDHC variations should be offered , as carriers may develop
isolated paragangliomas /
pheochromocytomas and occasionally other
tumors . -
pubmed
STIM1 elevation in the heart results in aberrant
Ca2 + handling and
cardiomyopathy . -
pubmed
STIM1 transgenic
mice exhibited
sudden cardiac death as early as 6weeks of age , while
mice surviving past 12weeks of age developed
heart failure with
hypertrophy , induction of the fetal gene program , histopathology and mitochondrial structural alterations , loss of ventricular functional performance and
pulmonary edema . -
pubmed
New Insight on the Role of
Plasminogen Receptor in
Cancer Progression . -
pubmed
OBJECTIVE :
Plasminogen system plays a crucial role in physiological and pathological events related to tissue regeneration ,
wound healing , immune response , angiogenesis , invasion and metastasis . -
pubmed
This review also discusses the possible effect of blocking these
plasminogen receptors with monoclonal antibodies and DNA - based vaccination or silencing
plasminogen receptor gene using small interfering RNA or short hairpin RNA to counteract
cancer invasion and metastasis . -
pubmed
Second - Trimester Maternal Serum
Paraxanthine ,
CYP1A2 Activity , and the Risk of Severe
Preeclampsia . -
pubmed
OBJECTIVE : To measure the association between second - trimester maternal
caffeine intake and
caffeine metabolism through the
CYP1A2 system and the risk of subsequent severe
preeclampsia . -
pubmed
The outcome of interest was severe
preeclampsia , and exposures were serum
paraxanthine (
1,7 - dimethylxanthine ) , measured through high - performance liquid chromatography , and
CYP1A2 activity , assessed by
paraxanthine /
caffeine ratios . -
pubmed
A sudden rise of
CRP serum values in the group A after 12 hours after application of haemostat was recorded , most probably as manifestation of the aseptic
pleuritic ( Tab . -
pubmed
Assessment of
glutathione S - transferaseM1 (
GSTM1 ) and its polymorphisms
GSTM1 null in the response to treatment with chemotherapy in advanced
ovarian carcinoma . -
pubmed
OBJECTIVE : To assess if the genotype of the
glutathione S - transferase M1 (
GSTM1 ) enzyme and its
GSTM1 null polymorphism can influence the response to chemotherapeutic treatment of advanced
ovarian cancer . -
pubmed
The tissue to study the
GSTM1 genotype and its deletion came from surgical staging to treat
ovarian cancer . -
pubmed
CONCLUSION : No difference was observed in the response to treatment with chemotherapy in
patients with advanced
ovarian cancer , as to the
GSTM1 genotype compared to its
GSTM1 null polymorphism . -
pubmed
Therefore , the present study was designed to examine immunomodulatory effects of BM - MSCs in the treatment of
myelin oligodendrocyte glycoprotein ( MOG ) 35 - 55 - induced
EAE in
C57BL / 6 mice . -
pubmed
Chronic inflammation is known to be associated with
visceral obesity and
insulin resistance and is characterized by altered levels of production of adipokines such as
tumor necrosis factor - alpha (
TNF - alpha ) ,
interleukin-1 (
IL-1 ) ,
IL-6 ,
leptin , and
adiponectin . -
pubmed
These findings are consistent with the supposition that EA inhibits proliferation and/or infiltration of macrophages into the adipose tissue of
obese rats and stimulates the release of
IL-10 from the decreased numbers of macrophages present in adipose tissue . -
pubmed
Evaluation of
NOTCH3 Pro167Ser Variation in a Japanese Family with
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and
Leukoencephalopathy . -
pubmed
CONCLUSIONS : Given the homogeneity of this series and the sensitivity of NGS in this low - cellularity
tumor , we demonstrated for the first time a poor prognostic role of
KRAS mutations . -
pubmed
Mice deficient in
N - acetylgalactosamine 4 - sulfate 6 - O - sulfotransferase exhibit enhanced
liver fibrosis and delayed recovery from
fibrosis in
carbon tetrachloride - treated
mice . -
pubmed
Our findings demonstrate that defect in
GalNAc4S-6ST , which resulted in disappearance of CS / DS containing
GalNAc(
4,6SO4 ) , appear to contribute to progression of
liver fibrosis , delayed recovery from
fibrosis , and various changes in the expression of proteoglycans and MMPs in
carbon tetrachloride - treated
mice . -
pubmed
ATM /
CHK /
p53 Pathway Dependent Chemopreventive and Therapeutic Activity on
Lung Cancer by
Pterostilbene . -
pubmed
To investigate the underlying mechanism of this superior action of
pterostilbene on cancer cells , we utilized a reverse - phase protein array followed by bioinformatic analysis and found that the
ATM /
CHK pathway is modified by
pterostilbene in a
lung cancer cell line . -
pubmed
To test this hypothesis , we used two molecularly defined precancerous
human bronchial epithelial cell lines ,
HBECR and
HBECR / p53i , with normal
p53 and suppressed
p53 expression , respectively , to represent premalignant states of
squamous lung carcinogenesis . -
pubmed
These results strongly support the potential chemopreventive effect of
pterostilbene on
p53 - positive cells during early
carcinogenesis . -
pubmed
However , the association between
NLR and
BC prognosis remains unclear . -
pubmed
In conclusion , this meta - analysis suggests that
NLR is a good prognostic marker for
BC , and patients with a higher NLR have poorer prognoses . -
pubmed
METHODS : Peripheral blood mononuclear cells from
HLA - A1 and
HLA - A2 HSV - seropositive
hereditary hemochromatosis donors were used as the antigen source . -
pubmed
Cultured cells were phenotyped and tested for
cytokine production , proliferation and
cytotoxicity . -
pubmed
The discovery that the most abundant
cholesterol oxidized metabolite in the plasma ,
27 hydroxycholesterol (
27 - OHC ) , is a selective
estrogen receptor modulator ( SERM ) and an agonist of
Liver X receptors (
LXR ) partially fills the void in our understanding and knowledge of the mechanisms that may link
hypercholesterolemia to development and progression of
breast cancer and
PCa . -
pubmed
The wide spectrum and repertoire of SERM and
LXR - dependent effects of
27 - OHC in the context of all facets and aspects of
breast cancer and
prostate cancer biology are reviewed in this manuscript in a very comprehensive manner . -
pubmed
Protective effects of
hydrogen sulfide on
portal hypertensive vasculopathy in
rabbits by activating
AKT -
NF - kappaB pathway . -
pubmed
H2S / CSE system may play an important role in remission of
PH via the
AKT -
NF - kappaB pathway . -
pubmed
Endothelial mineralocorticoid receptor contributes to
systolic dysfunction induced by pressure overload without modulating
cardiac hypertrophy or
inflammation . -
pubmed
Mineralocorticoid receptor (
MR ) antagonists block
aldosterone action and decrease mortality in
patients with
congestive HF However , the molecular mechanisms underlying the therapeutic benefits of
MR antagonists remain unclear . -
pubmed
Recently , we reported that
ICAM-1 regulates cardiac
inflammation and cardiac function in
mice subjected to transverse aortic constriction ( TAC ) . -
pubmed
Whether
MR specifically in endothelial cells ( EC ) contributes to the several mechanisms of pathological cardiac remodeling and
cardiac dysfunction remains unclear . -
pubmed
While EC - MR-/- TAC
mice showed preserved systolic function and some alterations in the expression of fetal genes , the proinflammatory
cytokine TNFalpha and the
endothelin receptors in the LV as compared to EC - MR+/+ TAC
mice , no difference was observed between both TAC groups in overall
cardiac hypertrophy ,
ICAM-1 LV expression and leukocyte infiltration ,
cardiac fibrosis or capillary rarefaction , all hallmarks of pathological cardiac remodeling . -
pubmed
Rats display increased
pain tolerance during pregnancy due to an increase in
opioid receptors in the spinal cord . -
pubmed
Only 24 % of those with recorded
HF symptoms followed a pathway aligned with guidelines ( echocardiogram and/or
serum natriuretic peptide test and specialist referral ) , while 44 % had no echocardiogram ,
natriuretic peptide test or referral . -
pubmed
Compelling evidence suggests a crucial role of
amyloid beta peptides (
Abeta ( 1 - 40 / 42 ) ) in the etiology of
Alzheimer ' s disease (
AD ) . -
pubmed
by
glutaminyl cyclase (
QC ) , is expected to enhance the
amyloid toxicity . -
pubmed
Hence , consecutive conversion of
Abeta ( 1 - 40 / 42 ) by
DPPIV and
QC can be assumed as a potential mechanism of formation of non - degrading pyroglutamated pE - Abeta(3 - 40/42 ) , which might accumulate and contribute to
AD progression . -
pubmed
Expression of
PD-1 /
PD - L1 and
PD - L2 in peripheral T - cells from
non - small cell lung cancer patients . -
pubmed
Binding of
programmed death-1 (
PD-1 ) with its ligands (
PD - L1 / 2 ) transmits a co - inhibitory signal in activated T - cells that promotes T - cell exhaustion , leading to
tumor immune evasion . -
pubmed
The efficacy of antibodies targeting
PD-1 and
PD - L1 has led to a paradigm shift in
lung cancer treatment but the prognostic and predictive value of
tumor PD - L1 expression remains controversial . -
pubmed
In this prospective observational study , plasma
cytokine levels and
PD-1 ,
PD - L1 and
PD - L2 expression was evaluated in circulating
CD3 + ,
CD3+
CD4 + and
CD3+
CD8 + cells from 70 treatment - naive
patients with advanced
NSCLC ( Stage IIIB and IV ) and from 10 healthy donors . -
pubmed
Our findings suggest that increased
PD-1 /
PD - L1 /
PDL-2 expression in PBMCs , particularly in T - cells , may be an additional mechanism leading to
tumor escape from immune control . -
pubmed
UCA1 impacts progress of
rheumatoid arthritis by inducing the apoptosis of fibroblast - like synoviocyte . -
pubmed
PATIENTS AND METHODS : qRT - PCR was used to detect the expression of
UCA1 in fibroblast - like synoviocyte from normal
people and
rheumatoid arthritis patients . -
pubmed
RESULTS : We found that the
UCA1 was highly expressed in the normal fibroblast - like synoviocyte ( NFLS ) , compared with the fibroblast - like synoviocyte of
rheumatoid arthritis (
RAFLS ) . -
pubmed
We also found that the decrease in
UCA1 expression increased the viability in
NFLS and overexpressed
UCA1 level in
RAFLS decreased the viability . -
pubmed
What 's more ,
UCA1 could affect the viability of
FLS by changing the expression of
Wnt6 . -
pubmed
CONCLUSIONS : According to the results , we found that
UCA1 was closely related to
rheumatoid arthritis , which could be a potential target for treating it . -
pubmed
Based on the BAS score , BD who were moderately BAS - affected ( n = 5 ) , had significantly lower arterial saturation of
hemoglobin with
oxygen values on arterial blood gas when compared with
MDD ( n = 18 ) . -
pubmed
Transient receptor potential vanilloid type 1 (
TRPV1 ) is implicated in
pain signaling and resides on sensory dorsal root ganglion ( DRG ) neurons . -
pubmed
We investigated the expression and functional activity of
TRPV1 in DRG neurons of the
Ins2+/Akita
mouse at 9 months of
diabetes using immunohistochemistry , live single cell
calcium imaging , and whole - cell patch - clamp electrophysiology . -
pubmed
Although
TRPV1 expressing neuron percentage was increased in
Ins2+/Akita DRGs at 9 months of
diabetes compared to control ,
capsaicin - induced
Ca2 + influx was smaller in isolated
Ins2+/Akita DRG neurons , indicating impaired
TRPV1 function . -
pubmed
We propose that in poorly controlled
diabetes , the accelerated rate of
capsaicin - sensitive
TRPV1 current decay in DRG neurons decreases overall
TRPV1 activity and contributes to
peripheral neuropathy . -
pubmed
Interaction of host immunity with
HER2 - targeted treatment and
tumor heterogeneity in
HER2 - positive breast cancer . -
pubmed
In addition ,
HER2 +
breast cancer is generally considered more immunogenic than
hormone receptor - positive (
HR+)/
HER2- , and specific molecular
HER2 + subgroups ( e.g. -
pubmed
HER2 - enriched
disease ) are more immunogenic than others ( e.g. -
pubmed
From a clinical perspective , the immune system plays a relevant prognostic role in
HER2 +
breast cancer and contributes to the therapeutic effects of trastuzumab . -
pubmed
Furthermore , the recent introduction in oncology of immune checkpoint inhibitors capable of unleashing anti - tumor immune response opens new possibilities for therapeutic combinations in
HER2 +
breast cancer . -
pubmed
Here , we review the current pre - clinical and clinical data on the interplay between the immune system and
HER2 +
breast cancer , focusing on different
HER2 - targeted treatments and the biological heterogeneity that exists within
HER2 + disease . -
pubmed
beta - Thalassemia ( beta - thal ) is the most frequently observed
hereditary blood disorder that results from
genetic defects causing
deficient synthesis of hemoglobin (
Hb ) polypeptide chains . -
pubmed
Chronic
cadmium exposure decreases the dependency of
MCF7 breast cancer cells on
ERalpha . -
pubmed
Cadmium is an environmental contaminant that can activate
estrogen receptor alpha (
ERalpha ) and contribute to the development and progression of
breast cancer . -
pubmed
Our lab previously demonstrated that chronic cadmium exposure alters the expression of several
ERalpha - responsive genes and increases the malignancy of
breast cancer cells . -
pubmed
Although these studies support cadmium 's function as a hormone disrupter , the role of
ERalpha in cadmium - induced
breast cancer progression remains unclear . -
pubmed
To address this , we modulated the expression of
ERalpha and found that while the loss of
ERalpha significantly impaired
cancer cell growth , migration , invasion and anchorage - independent growth in both
MCF7 and
MCF7 - Cd cells , cadmium - exposed cells retained a significant advantage in cell growth , migration , and invasion , and partially circumvented the loss of
ERalpha . -
pubmed
This is the first study to show that chronic cadmium exposure , even at low levels , can increase the malignancy of
breast cancer cells by decreasing their dependency on
ERalpha and increasing the adaptability of the
cancer cells . -
pubmed
Using cis - regulatory sequence analysis ,
STAT5 was identified as a regulator of DC activation and immune responses downstream of innate immune signaling that was not activated during either
WNV or ZIKV infection . -
pubmed
In this work , we identify
STAT5 as a regulator of DC activation and antiviral immune responses downstream of innate immune signaling that was not activated during either
WNV or Zika virus ( ZIKV ) infection . -
pubmed
Isocitrate dehydrogenase 1 (
IDH1 ) gene mutations have been observed in a majority of
diffuse astrocytomas ,
oligodendrogliomas , and
secondary glioblastomas , and the mutant
IDH1 R132H is detectable in most of these lesions . -
pubmed
Immunohistochemistry ( IHC ) detection of
IDH1 mutant protein may also be used to visualize single infiltrating
tumor cells in surrounding brain tissue with an otherwise normal appearance . -
pubmed
Celastrol - induced degradation of
FANCD2 sensitizes pediatric
high - grade gliomas to the DNA - crosslinking agent
carboplatin . -
pubmed
Since aberrant expression of DNA damage - response associated
Fanconi anemia proteins play a central role in the onset and therapy resistance of many
cancers , we here investigated if
FANCD2 depletion could sensitize pHGG to additional DNA damage . -
pubmed
METHODS : We determined the capacity of
celastrol , a BBB - penetrable compound that degrades
FANCD2 , to sensitize
glioma cells to the archetypical DNA - crosslinking agent
carboplatin in vitro in seven
patient - derived pHGG models . -
pubmed
FINDINGS :
FANCD2 is overexpressed in
HGGs and depletion of
FANCD2 by
celastrol synergises with
carboplatin to induce
cytotoxicity . -
pubmed
In addition , our results suggest that
celastrol treatment stalls ongoing replication forks , causing sensitivity to DNA - crosslinking in
FANCD2 - dependent
glioma cells . -
pubmed
INTERPRETATION : Our results show that depletion of
FANCD2 acts as a chemo - sensitizing strategy in
pHGG . -
pubmed
Immunohistochemically , the
tumor cells were strongly positive for
S-100 ,
GFAP , oligo-2 and
vimentin , focally positive for
synaptophysin and
CD34 , and negative for
cytokeratin ,
EMA ,
NeuN and
IDH1 . -
pubmed
A
BRAF V600E mutation was then identified in the
tumor . -
pubmed
Based on morphologic features , the immunohistochemical staining and
BRAF V600E mutation , the
tumor was diagnosed as a
PXA . -
pubmed
Inhibin B as a screening tool for early detection and treatment monitoring of
central precocious puberty . -
pubmed
Anti - Mullerian hormone (
AMH ) and
inhibin B are considered possible biomarkers of
central precocious puberty (
CPP ) . -
pubmed
The aim of this study was to evaluate serum levels of
AMH and
inhibin B , to investigate their regulatory patterns , and to study their clinical significance in
girls with
CPP . -
pubmed
Inhibin B was useful for determining CPP and the therapeutic effects of GnRHa treatment in
girls with
CPP . -
pubmed
AMH interacted , in part , with the hypothalamo - pituitary gonadal axis , but its clinical implications in
CPP should be further investigated . -
pubmed
lncRNA
ZEB1 -
AS1 inhibits high
glucose - induced EMT and fibrogenesis by regulating the miR-216a-5p /
BMP7 axis in
diabetic nephropathy . -
pubmed
Long non - coding RNA zinc finger E - box binding homeobox 1 antisense 1 (
ZEB1 - AS1 ) plays a crucial role in the development of various diseases , including
DN . -
pubmed
However , the molecular mechanism of
ZEB1 - AS1 in
DN pathogenesis remains elusive . -
pubmed
Western blot assay was used to evaluate the protein levels of
BMP7 , epithelial - to - mesenchymal transition ( EMT)-related proteins , and
fibrosis markers . -
pubmed
ZEB1 -
AS1 and
BMP7 were down - regulated , while miR-216a-5p was highly expressed in kidney tissues of
DN patients . -
pubmed
lncRNA
ZEB1 -
AS1 inhibited high
glucose - induced EMT and fibrogenesis via regulating miR-216a-5p /
BMP7 axis in
diabetic nephropathy , providing a potential target for DN therapy . -
pubmed
BACKGROUND : Denosumab is an inhibitor of
monoclonal receptor activator of nuclear factor - kB ligand , approved to treat
giant cell tumors of bone (
GCTB ) . -
pubmed
HLA Class I Allele Expression and Clinical Outcome in De Novo
Metastatic Prostate Cancer . -
pubmed
The prognostic value of
human leukocyte antigen ( HLA ) class I molecules in
prostate cancer (
PCa ) remains unclear . -
pubmed
Herein , we investigated the prognostic relevance of the most frequently expressed
HLA - A alleles in Greece ( A*02:01 and
HLA - A*24:02 ) in de novo metastatic hormone - sensitive
PCa (
mPCa ) , which is a rare and aggressive disease characterized by a rapid progression to castration - resistance ( CR ) and poor overall survival ( OS ) , contributing to almost 50 % of
PCa - related deaths . -
pubmed
Multivariate analyses ascribed to both
HLA alleles significant prognostic values for the time to progression (
TTP ) to CR and OS . -
pubmed
The presence of
HLA - A*02:01 and
HLA - A*24:02 alleles in de novo
mPCa patients are significantly and independently associated with unfavorable or favorable clinical outcomes , respectively , suggesting their possible prognostic relevance for treatment decision - making in the context of precision medicine . -
pubmed
Considering the defensive role of
vitamin D , mediated through modulation of the innate and adaptive immune system as well as inhibition of the
Renin Angiotensin System (
RAS ) ,
vitamin D supplementation might boost the immune system of
COVID-19 patients and reduce severity of the disease in
vitamin D deficient individuals . -
pubmed
Greater effect of polygenic risk score for
Alzheimer ' s disease among younger cases who are
apolipoprotein E - epsilon4 carriers . -
pubmed
To evaluate how age and
apolipoprotein E - epsilon4 (
APOE4 ) status interact with
APOE - independent polygenic risk score ( PRSnon -
APOE ) , we estimated PRSnon -
APOE in superagers ( age > = 90 years , N = 346 ) , 89- controls ( age 60 - 89 , N = 2930 ) , and
Alzheimer ' s disease (
AD ) cases ( N = 1760 ) . -
pubmed
Using superagers , we see a nearly 5 times greater odds ratio ( OR ) for
AD comparing the top PRSnon -
APOE decile to the lowest decile ( OR = 4.82 , p = 2.5 x 10 - 6 ) , which is twice the OR as using 89- controls ( OR = 2.38 , p = 4.6 x 10 - 9 ) . -
pubmed
Thus , the known
AD risk variants are particularly detrimental in young
APOE4 carriers . -
pubmed
The application of the histochemical demonstration of
AChE activity to the diagnosis of
congenital megacolon (
Hirschsprung ' s disease ) is discussed , both from the point of view of the technical aspects as well as the interpretation of the results obtained , using the method of Karnovsky and Roots , as modified by El Badawi - Schenk , applied to rectal suction biopsy . -
pubmed
, that the diagnosis of
Hirschsprung ' s disease can be done solely with the evaluation of the
AChE positive parasympathetic network of the lamina propria , with the additional consideration of the submucosal plexus to include cases of
hypoganglionar megacolon , where that plexus is clearly diminished . -
pubmed
These patterns were compared with those of acute ocular responses to various types of
injuries caused by
fromalin ,
bacterial endotoxins and immunological sensitization with
bovine albumin . -
pubmed
Genomic variability and alternative splicing generate multiple PML / RAR alpha transcripts that encode aberrant
PML proteins and
PML / RAR alpha isoforms in
acute promyelocytic leukaemia . -
pubmed
The
PML / RAR alpha proteins varied among
bcr1 , 2 and 3
APL cases and within single cases . -
pubmed
[ Levels of blood
pepsinogen I in the offspring of
patients with
duodenal ulcer ] . -
pubmed
By establishing an upper normal value of PG I , we identified a subpopulation of normopepsinogenemic
ulcerous patients and another with high values ( 9 normo PG I : 64.3 + /- 6.2 ng / ml vs 16 ulcerous patients with
PG I levels : 142.1 + /- 19 ng / ml ) ( p & lt ; 0.001 ) . -
pubmed
Immunoreactive
transforming growth factor alpha is commonly present in
colorectal neoplasia . -
pubmed
Surgical specimens from 19
patients with invasive
colorectal cancers and 12 specimens of
normal mucosa from the same
patients were examined immunohistochemically for the production of the immunoreactive ( IR- )
transforming growth factor ( TGF )- alpha and
IR - epidermal growth factor (
EGF ) with an anti -
TGF - alpha monoclonal antibody ( MAb ) OAL -
MTG01 and anti -
EGF MAb
KEM-10 . -
pubmed
Immunoreactive
TGF - alpha was detected in 16 ( 84.2 % ) of 19
colorectal cancers . -
pubmed
In contrast , there was no
IR - TGF - alpha in the gland cells of
normal mucosa . -
pubmed
Immunoreactive
EGF was detected in 7 ( 36.8 % ) of 19
colorectal cancers and 1 ( 8.3 % ) of 12 cases of
normal mucosa . -
pubmed
The production of both
IR - TGF - alpha and
IR - EGF in
colorectal cancer did not differ by histologic type and Dukes ' stage . -
pubmed
Immunoreactive
TGF - alpha was detected at significantly higher incidence than
IR - EGF in
colorectal cancer . -
pubmed
These results indicate that
IR -
TGF - alpha should prove valuable as a possible
tumor marker in
colorectal cancers , and it may be very useful in understanding the biology of
colorectal cancer . -
pubmed
This study investigated the influence of age on the pharmacokinetics , pharmacodynamics , general tolerability and concentration - effect relationships in 18
patients with
essential hypertension ( age range 23 - 73 years ) during treatment with
dilevalol , a non selective
beta - adrenoceptor antagonist with vasodilator properties . -
pubmed
Interferon therapy of
chronic delta hepatitis in
patients cured of
pediatric malignancies : possible harmful effect . -
pubmed
The severity of
liver disease in many of these patients prompted us to start a pilot study on the effect of recombinant
alpha 2b interferon , given at a dose of 5 MU / square meter thrice weekly . -
pubmed
The results of this study , which has been interrupted at the 4th month , suggest that
interferon therapy for
chronic delta hepatitis has to be considered cautiously in young patients cured of
pediatric malignancies . -
pubmed
These were ( i ) that the eosinophil expressed
Fc gamma RII (
CDw32 ) only ( unlike monocytes which bear
Fc gamma RI and
Fc gamma RII and neutrophils which bear
Fc gamma RII and
Fc gamma RIII ) ; ( ii ) that the absence of
Fc gamma RIII (
CD16 ) on eosinophils served as a basis for distinguishing eosinophil and neutrophil populations by immunofluorescence ; ( iii ) that the
leucocyte adhesion glycoproteins ,
LFA-1 alpha (
CD11a ) ,
CR3 - alpha (
CD11b ) ,
p150 ,
95 - alpha (
CD11c ) and the
common beta - chain (
CD18 ) , were expressed on the eosinophil as well as the neutrophil ; ( iv ) that
CD18 expression was significantly reduced on low - density eosinophils from the
hypereosinophilic syndrome . -
pubmed
Cancer was found more commonly in patients with idiopathic
deep vein thrombosis (
DVT ) ( 7 of 31 versus 5 of 82 patients with secondary
DVT ; P = 0.012 ) , and in those patients with abnormal
lactic dehydrogenase (
LDH ) levels ( 6 of 23 versus 6 of 90 ; P = 0.007 ) . -
pubmed
Abnormal
CEA levels allowed diagnosis of two cases of
colonic cancer ( on colonoscopy ) . -
pubmed
It was concluded that blood cell counts ,
LDH ,
CEA , chest radiograph , and abdominal ultrasonography ( or CT scan ) should be routinely performed on all patients with
deep venous thrombosis ( particularly those with idiopathic
DVT ) . -
pubmed
Continuous subcutaneous
insulin infusion versus injection therapy : a randomized cross - over trial under usual
diabetic clinic conditions . -
pubmed
Twelve
C - peptide negative
insulin - dependent
diabetic patients participated in a randomized cross - over study of 6 months treatment with twice or thrice daily
insulin injection therapy and continuous subcutaneous
insulin infusion ( CSII ) . -
pubmed
A novel putative mediator of
insulin action which acts to inhibit
adenylate cyclase and
cAMP - dependent protein kinase has been purified from livers of
insulin - treated
streptozotocin -
diabetic rats . -
pubmed
[
Pyruvate kinase activity of erythrocytes in
hereditary non - spherocytic hemolytic anemias ] . -
pubmed
[
Adrergic beta - receptor blocking with
propranolol in some
disorders of cardiac rhythm ] . -
pubmed
Chemotaxis of polymorphonuclear leucocytes in vivo was studied in
patients with previous
yersinia arthritis and in healthy subjects with or without
HLA B27 by means of a skin chamber technique . -
pubmed
Irrespective of previous
arthritis the number of neutrophils in the chamber media was significantly higher in
HLA B27 positive subjects than in those without
HLA B27 . -
pubmed
The present results give credence to the view that the hyperreactive neutrophils and the vasodilatory
prostaglandins produced by them can together trigger a vicious circle which results in increased inflammatory symptoms in
patients with
yersinia arthritis who have
HLA B27 as compared with those who lack this
antigen . -
pubmed
In this study , we investigated the presence of
NTFs in cerebrospinal fluid ( CSF ) of
patients with
central nervous system ( CNS ) injury . -
pubmed
In the 11
patients from whom consecutive CSF samples were available ,
NTF activity assayed in
rat hippocampal cultures tended to decrease during the first several days after
CNS injury . -
pubmed
The
hypoproliferative anemia in
chronic renal failure has been assumed to be the result of decreased
erythropoietin (
Ep ) production by the damaged kidney and of the shortening of erythrocyte survival . -
pubmed
Hepatic
catalase in
rats bearing
Walker tumor in the brain . -
pubmed
Rats were injected with 10(5 ) cells of
Walker carcinosarcoma 256 in ascites form into discrete areas of the brain ( RAS , midbrain - hypothalamus , and anterior and posterior cortex ) , and at necropsy on the sixth day postoperation the
animals were sacrificed , the brains were examined for
tumors , and liver homogenates were analyzed for
catalase content . -
pubmed
Liver
catalase was little altered in
rats with solid
tumors in the various brain areas originating from fragments measuring 1 mm3 and harvested from donors with intramuscular
Walker tumor , as was also the case with
tumor - free
rats submitted to hypothalamic lesioning . -
pubmed
Immunohistochemical examination of the dermal collagen bundles showed a
collagen pattern similar to
systemic sclerosis and normal control skin . -
pubmed
CONCLUSION : The sclerotic skin changes in
GEMSS syndrome are the result of an abnormally increased production of normal
collagen that might be attributable to the enhanced in situ production of
transforming growth factor beta 1 . -
pubmed
ALL-1 partial duplication in
acute leukemia . -
pubmed
BACKGROUND : Heavy smoking ;
dyslipoproteinemias involving
very low density lipoprotein (
VLDL ) ,
low density lipoprotein (
LDL ) and
high density lipoprotein (
HDL ) ; a family history of premature
coronary artery disease ; hyperinsulinemic responses to oral and intravenous
glucose challenges ; and defective fibrinolytic function characterize the young postinfarction
patient , but the influence of these features on the long - term prognosis is virtually unknown . -
pubmed
In multivariate analysis ,
VLDL and global coronary
atherosclerosis score predicted
reinfarction ; plasma
plasminogen activator inhibitor-1 (
PAI-1 ) activity and global
coronary stenosis score predicted
cardiac death ; and
VLDL triglyceride levels , global coronary
atherosclerosis score and age predicted any major coronary event . -
pubmed
CONCLUSIONS : This prospective cohort study shows that
hypertriglyceridemia , impaired fibrinolytic capacity secondary to plasma
PAI-1 activity elevation and extensive
coronary artery disease increase the risk of recurrences in men with a first
myocardial infarction before age 45 and contribute to the relatively poor long - term prognosis in this
patient group . -
pubmed
Increased levels of the
Kunitz protease inhibitor - containing beta
APP mRNAs in
rat brain following
neurotoxic damage . -
pubmed
Deposits of
beta - amyloid are one of the main pathological characteristics of
Alzheimer ' s disease . -
pubmed
Increased levels of the KPI - containing beta
APP and
GFAP mRNAs were observed in tissues surrounding areas of
neuronal damage . -
pubmed
These results suggest that the normal ratio of beta
APP isoforms may be profoundly altered as a result of
neuronal damage and that non - neuronal cells may respond to
neuronal injury by increased expression of the KPI - containing beta
APP isoforms . -
pubmed
Total
lysophosphatidylcholine concentration ( sum of
lysophosphatidylcholine remaining in tissue and
lysophosphatidylcholine released into the buffer ) increased from 0.73 + /- 0.08 nmol / mg protein at baseline to 1.83 + /- 0.45 nmol / mg protein after 5 minutes of
ischemia ( p & lt ; 0.001 ) , and was associated with evidence of cell injury ( 26 % depletion of tissue
lactate dehydrogenase ) . -
pubmed
Cathepsin D serum mass concentrations in
patients with
hepatocellular carcinoma and/or
liver cirrhosis . -
pubmed
Cathepsin D serum mass concentrations were determined by enzyme immunoassay in
patients with
hepatocellular carcinoma ( n = 51 ) and/or
liver cirrhosis ( n = 92 ) or
benign steatosis ( n = 16 ) and correlated with some biochemical and clinical properties of these diseases . -
pubmed
Interestingly , significantly higher
cathepsin D serum mass concentrations ( mean + 62 % ) ( P & lt ; 0.006 ) were determined in the
cirrhosis group as compared to
cancer patients . -
pubmed
No correlation between
cathepsin D and a number of clinical and biochemical properties examined , namely ,
alpha - foetoprotein , number of
neoplastic lesions and
tumour size in
cancer patients or , Child - Pugh grade of severity of
cirrhosis and other enzymes of liver function tests in the
cirrhotic group was found . -
pubmed
The present data and those from other studies which indicate that
cathepsin D may be involved in carcinogenesis suggest that this enzyme may be potentially useful as an additional biochemical marker to identify
cirrhotic patients who may develop
precancerous hepatic nodules . -
pubmed
OBJECTIVE : The present
animal study investigates the influence of an acute and almost complete isovolaemic
haemodilution with a new ultrapurified polymerized
bovine haemoglobin (
UPBH ) on hepatic and renal function and histology in comparison to
hydroxyethylstarch (
HES ) . -
pubmed
[ Characterization of the
BRCA1 gene and its significance in
hereditary breast cancer ] . -
pubmed
Fibrates may be useful in
patients with
hypertriglyceridemia , and/or low
HDL -
cholesterol level or in the case of intolerance to
statins . -
pubmed
BACKGROUND :
Monoclonal gammopathies - including so - called
monoclonal gammopathies of undetermined significance -
MGUS - may cause
polyneuropathies , even if
immunoglobulin concentrations are within a normal range . -
pubmed
CASE REPORT : We report on a
patient with a rapidly progressive
polyneuropathy with severe motor disturbances in whom a small amount of a
monoclonal IgM kappa cryoglobulin was found . -
pubmed
CONCLUSION : This case shows that in
patients with a
polyneuropathy of uncertain etiology
monoclonal immunoglobulins should be looked for and that a
MGUS can precede a
lymphoma . -
pubmed
We investigated the mechanisms underlying stimulation of
rapidly adapting receptors (
RARs ) during
pulmonary air embolism (
PAE ) . -
pubmed
Thus
adenosine could not be responsible for the increase in coronary blood flow after
adenosine receptor blockade and therefore is not required for
norepinephrine - induced
hyperemia . -
pubmed
Cytokines in
autoimmune disease . -
pubmed
Tumor cell immunoreactivity for
HMB-45 and nonreactivity for
cytokeratin supported the diagnosis . -
pubmed
Meta - analysis of
streptokinase and
heparin in
deep vein thrombosis . -
pubmed
The efficacy and safety of
streptokinase and
heparin in
deep vein thrombosis (
DVT ) were compared in a meta - analysis . -
pubmed
Randomized trials in which
streptokinase ( followed by
heparin ) and
heparin alone were compared in treating phlebographically documented acute
DVT were identified from MEDLINE and other sources for a meta - analysis . -
pubmed
Significantly more
streptokinase recipients achieved
thrombolysis than recipients of
heparin alone ( summary OR , 6.24 ; 95 % CI , 3.62 to 10.78 ) . -
pubmed
The frequency of major
bleeding was significantly higher among
streptokinase recipients than recipients of
heparin alone ( summary OR , 3.78 ; 95 % CI , 1.26 to 11.32 ) . -
pubmed
A meta - analysis showed that , compared with
heparin alone ,
streptokinase therapy for
DVT was associated with significantly more frequent
thrombolysis and major
bleeding ; after exclusion of one outlying study , analysis showed that
streptokinase therapy was associated less frequently than
heparin alone with postthrombotic changes ( assessed by phlebographic evaluation ) and
postphlebitic syndrome . -
pubmed
Our data showed the
CD markers expression for common
ALL ( c - ALL ) were
CD19+/10 + ( 100 % ) ,
CD20 + ( 24 % ) ,
CD22 + ( 100 % ) ,
HLA - DR+ ( 70.1 % ) , and
CD34 + ( 58.8 % ) . -
pubmed
CD markers expression for
B - ALL were
CD19 + ( 100 % ) ,
CD20 + ( 33.3 % ) ,
CD22 + ( 80 % ) , and
HLA - DR+ ( 80 % ) . -
pubmed
CD markers expression for
T - ALL were
CD3 + ( 42.9 % ) ,
CD5 + ( 100 % ) ,
CD7 + ( 85.7 % ) . -
pubmed
Although the mechanisms by which
LVH develops are incompletely understood , the
renin -
angiotensin system may play an important role . -
pubmed
All major classes of antihypertensive agents (
calcium channel blockers , diuretics , beta - blockers ,
angiotensin - converting enzyme inhibitors ) can cause
LVH regression but not all to the same degree . -
pubmed
In addition , animal studies and
human trials show promise for the regression of
LVH with the use of
angiotensin receptor blockers ( ARBs ) . -
pubmed
Neuroprotective gene therapy for
Huntington ' s disease using a polymer encapsulated
BHK cell line engineered to secrete
human CNTF . -
pubmed
Analysis of the
DMBT1 gene in
carcinomas of the respiratory tract . -
pubmed
Therefore , we investigated
DMBT1 in 25
cancer cell lines and 39 primary
tumors of the respiratory tract . -
pubmed
In summary , our data do not confirm previous findings reporting frequent loss of
DMBT1 expression in
lung cancer . -
pubmed
Overexpression of lymphocytic GD3 ganglioside and presence of
anti - GD3 antibodies in
patients with
HIV infection . -
pubmed
We report here the results obtained by both ex vivo and in vitro experiments on ( 1 ) surface and cytoplasmic expression and distribution of GD3 in
HIV - infected cells , ( 2 ) the presence of
anti - GD3 antibodies in sera of
patients with
HIV infection in various stages of the disease , and ( 3 ) the association of GD3 expression with HIV - related apoptotic events . -
pubmed
Interestingly , ex vivo studies of lymphocytes from
patients with
HIV infection also indicated that GD3 expression is strictly associated with
annexin V binding , an early marker of apoptosis . -
pubmed
A region - specific , modest increase in DA levels and
TH - positive fiber density in the ventral - medial putamen was detected , accompanied by modest but significant decreases in
parkinsonian behaviors at 5 - 6 months after grafting . -
pubmed
Most cases of
T - PLL express
membrane T - cell receptors (
TCRs ) of the alphabeta phenotype . -
pubmed
In addition experimental
infection of
turkey poults with
APV / MN-12 resulted in detection of viral RNA in nasal turbinates and
APV - specific
IgG in serum . -
pubmed
Cervical
cat scratch disease lymphadenitis in a
patient with
immunoglobulin M antibodies to
Toxoplasma gondii . -
pubmed
Serological follow - up studies , including testing for avidity of
Toxoplasma - specific
immunoglobulin G antibodies , assisted in the determination of the cause of the acute
lymphadenitis . -
pubmed
To elucidate the relationship between changes in
Ca2 + dynamics and gap junctions , we analyzed by real - time in situ
Ca2 + imaging of
fluo-3 loaded whole hearts the spatiotemporal occurrence of
Ca2 + waves and the localization of
connexin43 (
Cx43 ) at the border zone of
myocardial infarcts induced in the
rat by coronary ligation . -
pubmed
Confocal imaging of
Cx43 and
actin filaments in the
rat heart fixed 2 hours after coronary ligation revealed that
Cx43 was markedly decreased in the area of myocyte
necrosis with contraction bands and in the neighboring myocardium . -
pubmed
Opportunities for studying
cancer by metabolomics : preliminary observations on
tumors deficient in
hypoxia - inducible factor 1 . -
pubmed
Neurogenic atherosclerosis mediated by
neuropeptide y : hardening of the evidence . -
pubmed
GENETIC CONTROL OF CELLULAR SUSCEPTIBILITY TO
PSEUDOTYPES OF ROUS SARCOMA VIRUS . -
pubmed
Overactivation of
glycogen synthase kinase-3 by inhibition of
phosphoinositol-3 kinase and
protein kinase C leads to hyperphosphorylation of
tau and
impairment of spatial memory . -
pubmed
Neurofibrillary tangles ( NFTs ) consisting of the hyperphosphorylated microtubule - associated protein
tau are a defining pathological characteristic of
Alzheimer ' s disease (
AD ) . -
pubmed
However , molecular mechanisms underlying overactivation of
GSK-3 and its potential linkage to
AD - like pathologies in vivo remain unclear . -
pubmed
Here , we demonstrate that injection of
wortmannin ( a specific inhibitor of
phosphoinositol-3 kinase ) or
GF-109203X ( a specific inhibitor of
protein kinase C ) into the left ventricle of
rat brains leads to overactivation of
GSK-3 , hyperphosphorylation of
tau at
Ser 396/404/199/202 and , most significantly ,
impaired spatial memory . -
pubmed
Significantly , specific inhibition of
GSK-3 activity by
LiCl prevents hyperphosphorylation of
tau , and spatial
memory impairment resulting from
PI3 K and
PKC inhibition . -
pubmed
These results indicate that in vivo inhibition of
phosphoinositol-3 kinase and
protein kinase C results in overactivation of
GSK-3 and
tau hyperphosphorylation and support a direct role of
GSK-3 in the formation of
AD - like
cognitive deficits . -
pubmed
Hypoxia , the reduction of
oxygen supply , results in adaptationally appropriate alterations in gene expression through the activation of
hypoxia - inducible factor 1 (
HIF-1 ) to overcome any shortage of
oxygen . -
pubmed
Increased synthesis of
HIF-1alpha may contribute to the adaptive response of increased
oxygen demand under
hyperthyroid conditions . -
pubmed
Chromosome band 16q22 - linked familial
AML : exclusion of candidate genes , and possible disease risk modification by
NQO1 polymorphisms . -
pubmed
Analyses of chromosomal translocation and inversion breakpoints in sporadic
acute myeloid leukemias have identified many
transcription factors as playing a role in leukemogenesis . -
pubmed
Studies of families with a Mendelian predisposition to
hematological malignancies have identified the gene coding for the
transcription factor RUNX1 as a
leukemia - predisposing gene involved in the first steps of leukemogenesis . -
pubmed
Although
CBFB forms a core - binding factor transcriptional complex with
RUNX1 , previous analyses have excluded the CBFB gene as the
leukemia - predisposing gene in these families . -
pubmed
We demonstrated that the transcription factors
E2F4 ,
CTCF ,
NFATC3 , and
NFAT5 , and the genes coding for
NAD ( P ) H : quinone oxido - reductase 1 (
NQO1 ) and for
E - cadherin are not responsible for the
leukemia susceptibility in these families . -
pubmed
p38 alpha mitogen - activated protein kinase inhibition improves cardiac function and reduces
myocardial damage in
isoproterenol - induced acute
myocardial injury in
rats . -
pubmed
p38 mitogen - activated protein ( MAP ) kinase is activated during ischemic / hypoxic
myocardial injury . -
pubmed
However , the role of activated
p38 MAP kinase on cardiac function after
myocardial injury is not well understood . -
pubmed
In the present study , we investigated the cardioprotective effects of
p38 MAP kinase inhibition in a
rat model of acute
myocardial injury , induced by subcutaneous injection of
isoproterenol (
ISO , 20 mg / kg / d for 3 days ) . -
pubmed
Cardiac function , systolic blood pressure , gene expression including
collagen I and III ,
fibronectin and
COX-2 , and the
myocardial injury were analyzed . -
pubmed
Data suggest that
p38 alpha MAP kinase may be involved in the pathogenesis of
cardiac dysfunction in ischemic
myocardial injury . -
pubmed
Type 1 diabetes is the result of an autoimmune attack against the
insulin - producing beta cells of the endocrine pancreas . -
pubmed
Current treatment for
patients with
type 1 diabetes typically involves a rigorous and invasive regimen of testing blood
glucose levels many times a day along with subcutaneous injections of recombinant DNA - derived
insulin . -
pubmed
Tumor ploidy , percent 4/5 Gleason grade and pathological stage were strong predictors of outcome , while margin status and preoperative
prostate specific antigen had minimal predictive strength . -
pubmed
OBJECTIVE : To investigate the effects of Benefiting - bone capsule ( BBC ) on the expression of
transforming growth factor - beta1 mRNA in bone tissue of the ovariectomized
rats to further explain the mechanism of BBC on preventing and treating
osteopoprosis . -
pubmed
Ovariectomy was used to establish the
osteoporotic animal model and the expression of
TGF - beta1 mRNA on gene level in bone tissue was detected by real time fluorescence quantitative PCR ( FQ - PCR ) method . -
pubmed
RESULTS : The expression of
TGF - beta1 mRNA on gene level in bone tissue of the groups of
osteoporotic animal model with BBC were all higher than that of the groups of
osteoporotic animal model , which were close to the groups of sham operation . -
pubmed
The increased risk of
premature cardiovascular disease (
CVD ) in
rheumatoid arthritis (
RA ) patients may depend on traditional risk factors but may also be attributable to
RA - specific risk factors such as disease - related
dyslipidemia , or
cytokines such as
tumor necrosis factor - alpha (
TNF - alpha ) . -
pubmed
TNF - alpha may play a role in the triggering and perpetuation of
atherosclerosis . -
pubmed
Treatment with biologic agents directed against
TNF - alpha has significant clinical benefits in
inflammatory diseases such as
RA and may be able to reduce cardiovascular risk . -
pubmed
The disappointing results of the recent studies to antagonize
TNF - alpha in
CVD may have various explanations . -
pubmed
However , the effects of
TNF - alpha blockers on incident cases of
congestive heart failure (
CHF ) in
RA remains controversial . -
pubmed
Due to the lack of evidence of a beneficial effect of anti -
TNF - alpha agents in treatment of
CHF , they should not be used to treat
patients with New York Heart Association ( NYHA ) class III or IV
heart failure . -
pubmed
In a
mouse pneumonia model the
slrA knock - out
D39DeltaslrA did not cause significant differences in the survival times of
mice compared with the isogenic wild - type strain . -
pubmed
These results suggested that
SlrA is involved in colonization but does not contribute significantly to invasive
pneumococcal disease . -
pubmed
In cell culture infection experiments , the absence of
SlrA impaired adherence to
pneumococcal disease - specific epithelial and
endothelial non - professional cell lines . -
pubmed
In conclusion ,
SlrA is a functional , cyclophilin - type
PPIase and contributes to pneumococcal virulence in the first stage of
infection , namely , colonization of the upper airways , most likely by modulating the biological function of important virulence proteins . -
pubmed
Vitamin D in
chronic kidney disease : a systemic role for selective
vitamin D receptor activation . -
pubmed
Hyperparathyroidism occurs in most
patients during the progression of
chronic kidney disease (
CKD ) and one of its initiating events , reduced serum levels of
1,25 - dihydroxyvitamin D , results from a decrease in renal
1alpha hydroxylase activity , which converts
25 - hydroxyvitamin D to its activated form . -
pubmed
The combination of persistently high
parathyroid hormone (
PTH ) and low
1,25 - dihydroxyvitamin D is associated with
bone loss ,
cardiovascular disease ,
immune suppression and increased mortality in
patients with
end - stage kidney failure . -
pubmed
One hypothesis derived from such studies suggests that systemic activation of
VDRs may have direct effects on the cardiovascular system to decrease mortality in
CKD . -
pubmed
Although current guidelines for regulating serum
calcium ,
phosphate and
PTH recommend specific interventions at the various stages of
CKD to prevent or postpone irreversible
parathyroid disease and decrease cardiovascular morbidity and mortality , emerging data suggest that
vitamin D therapy may prolong survival in this
patient population by mechanisms that are independent of
calcium ,
phosphate and
PTH . -
pubmed
It is suggested that a re - evaluation of current treatment recommendations is needed and that future research should focus on mechanisms that distinguish potential tissue specific benefits of selective
VDR activators in
patients with
CKD . -
pubmed
On the road to discovering protective endogenous
peroxisome proliferator - activator receptor - gamma ligands for
endotoxemia : are we there yet ? -
pubmed
Effect of liver regeneration after partial hepatectomy and
ischemia - reperfusion on expression of
growth factor receptors . -
pubmed
AIM : To investigate the effects of experimental partial hepatectomy and normothermic
ischemia - reperfusion damage on the time course of the expression of four different
growth factor receptors in liver regeneration . -
pubmed
The
epidermal growth factor receptor ,
hepatic growth factor receptor ,
fibroblast growth factor receptor and
tumour necrosis factor receptor-1 were analysed by immunohistochemistry up to 72 h after
injury . -
pubmed
RESULTS : In immunohistochemistry ,
EGFR ,
HGFR ,
FGFR and
TNFR1 showed biphasic kinetics after partial hepatectomy with a peak up to 12 h , a nadir after 24 h and another weak increase up to 72 h. During liver regeneration , after
ischemia and reperfusion , the receptor expression was lower ; the nadir at 24 h after reperfusion was the same . -
pubmed
All
patients should be screened for
peritoneal fluid amylase levels in order to differentiate
bacterial peritonitis from intra - abdominal pathology . -
pubmed
Propofol reduces
pulmonary edema by prevention of
cytokine - mediated impairment of alveolar ion and fluid transport . -
pubmed
Molecular characterisation of
pyruvate kinase deficiency -- concerns about the description of mutant
PKLR alleles . -
pubmed
Here , we studied in a
nude mouse model whether the expression of
VEGF - A in a
tumor could be imaged with a radiolabeled anti -
VEGF antibody . -
pubmed
The accumulation of the radiolabeled antibodies in
VEGF - A expressing
tumors (
LS174 T ) in
nude mice was examined in biodistribution studies and by gamma camera imaging . -
pubmed
Coinjection of an excess unlabeled antibody resulted in a significant decrease in radioactivity concentration in the
tumor ( & lt;2.9 + /- 1.9 % ID / g , p & lt ; 0.005 ) , indicating
VEGF - mediated antibody uptake . -
pubmed
VEGF - A - expressing
tumors could be clearly visualized on planar scintigraphic images from 24 - hr post injection onwards . -
pubmed
In conclusion ,
VEGF - A expression in
tumors can be visualized specifically with radiolabeled anti -
VEGF - A - mAb . -
pubmed
AXIN2 and
CDH1 polymorphisms ,
tooth agenesis , and
oral clefts . -
pubmed
We investigated if
AXIN2 and
CDH1 polymorphisms were associated with
clefts or with any associated dental subphenotypes . -
pubmed
RESULTS : Comparison between cleft and control groups showed a trend for association for
AXIN2 with
incomplete cleft palate ( p = .006 ) and
CDH1 with
unilateral CL / P ( p = .03 for left CL / P and p = .04 for right CL / P ) . -
pubmed
Comparison of cleft subphenotypes with
tooth agenesis and controls revealed borderline associations for
CDH1 ( p = .008 ) and
AXIN2 ( p = .01 ) with unilateral right CL / P with
tooth agenesis . -
pubmed
CONCLUSIONS : We observed only borderline results for the association of
AXIN2 and
CDH1 with
CL / P with and without
tooth agenesis . -
pubmed
A major focus of our research is to understand the molecular and cellular basis of
X - linked lymphoproliferative disease (
XLP ) , a rare and often fatal
immunodeficiency caused by mutations in the
SH2D1A gene , which encodes the
adaptor molecule SAP . -
pubmed
Recently , we observed that
SAP is essential for the development of natural killer T ( NKT ) cells , a lymphocyte population that participates in protection against certain
tumors ,
infections , and autoimmune states . -
pubmed
By using
SAP as the focal point of our studies , we hope to identify novel signaling pathways that could be targeted to improve the treatment for
patients with
XLP as well as more common disorders , such as
autoimmunity and
cancer . -
pubmed
Major topics focus on selected
bladder cancer markers from nearly all categories of the wide field of
bladder cancer markers :
Hematuria , FISH ,
FGFR3 ,
SURVIVIN ,
u - PAR ,
TP53 mutation ,
HER-2 / neu ,
TPA ,
NMP22 ,
CK-19 ,
CK-20 ,
CYFRA 21 - 1 . -
pubmed
Maternal
CMV DNAemia remained a significant risk factor for mortality in
HIV-1 - infected infants after adjusting for maternal
CD4 cells / microl [ adjusted hazard ratio ( HR ) = 4.3 , confidence interval ( CI ) = 1.4 - 13 ] ,
CD4 % ( HR = 3.2 , CI = 1.0 - 10 ) ,
HIV-1 viral load ( HR = 4.1 , CI = 1.4 - 12 ) or maternal death ( HR = 3.7 , CI = 1.0 - 13 ) . -
pubmed
Acromegaly : correlation between expression of
somatostatin receptor subtypes and response to
octreotide - lar treatment . -
pubmed
This study analyzes
SSTR ' s expression in
somatotrophinomas , comparing to
SA response , hormonal levels , and
tumor volume . -
pubmed
SSTR3 was more expressed in
patients with
tumor reduction . -
pubmed
There was a positive correlation between the percentage of
tumor reduction and
SSTR1 ,
SSTR2 and
SSTR3 expression . -
pubmed
Our study confirmed the association between the
SA response to
GH and
IGF - I and the
SSTR2 . -
pubmed
Huntington ' s disease (
HD ) is an
autosomal dominantly inherited disorder , caused by an expanded
polyglutamine region of a protein called
huntingtin . -
pubmed
Cardiac troponin I degradation in serum of
patients with
hypertrophic obstructive cardiomyopathy undergoing percutaneous septal ablation . -
pubmed
INTRODUCTION :
Troponin has become the most important marker for diagnosing
acute myocardial infarction , yet knowledge is scarce regarding appearance of specific degradation fragments in the blood . -
pubmed
We have recently described the appearance of intact
cardiac troponin I (
cTnI ) and 7 degradation products in
patients suffering from
ST - elevation myocardial infarction (
STEMI ) using Western blot analysis . -
pubmed
Here the iatrogenic induction of
myocardial necrosis occurs in vivo , allowing us to investigate degradation of
cTnI by the second . -
pubmed
Western blot analysis was performed with subsequent analysis of relative intensities of the bands as compared to the degradation of
cTnI in
STEMI patients from the ASSENT-2
troponin substudy . -
pubmed
Their early rise in intensity , occurring within few minutes after the
alcohol injection , emphasizes how susceptible
troponin bands are to chemical /
ischemic insults . -
pubmed
CONCLUSION : This work describes the degradation products of
troponin I in
HOCM patients undergoing PTSMA . -
pubmed
Hodgkin ' s lymphoma : the role of
cell surface receptors in regulation of
tumor cell fate . -
pubmed
Despite the loss of
BCR - the master - regulator of B cell fate ,
HRS cells express a number of receptors that regulate
tumor cell survival . -
pubmed
Due to the mutations in genes encoding proteins of
CD95 - mediated apoptotic signaling pathway , it is not functional in
HRS cells . -
pubmed
Ligands of
TNF family receptors on cells in
HL microenvironment contribute to the activation of canonical and non - canonical
NF - kappaB signaling pathways and survival program of
HRS cells . -
pubmed
Moreover , in
HRS cells a number of multiple mutations in negative
NF - kappaB regulators , and also gains and amplifications of
positive regulators , cooperate in deregulating these pathways . -
pubmed
CONCLUSION : The review presents the current views on the role of
cell surface receptors in maintenance of
HL microenvironment favorable for
HRS cells survival . -
pubmed
Immunization of knock - out alpha /
beta interferon receptor mice against lethal
bluetongue infection with a BoHV-4 - based vector expressing
BTV-8 VP2 antigen . -
pubmed
IFNAR(-/- )
mice intraperitoneally inoculated twice with
BoHV-4 - A - IgK - VP2gDtm at different time points developed serum neutralizing antibodies against
BTV and showed a strongly reduced
viremia and a longer survival time when challenged with a lethal dose of
BTV-8 . -
pubmed
Specific
GATA inhibitors have recently been developed as novel drugs for the management of
anemia . -
pubmed
The results showed that the expression of
fetuin - B in
mice plasma was increased by
K-11706 , but not by recombinant
human erythropoietin or
hypoxia . -
pubmed
Tight
glucose control ( TGC ) using a sliding scale based on intermittent blood
glucose measurements occasionally can have a fatal outcome as a result of
insulin - induced
hypoglycemia . -
pubmed
The serum levels of
S100A12 and
HMGB-1 tended to decrease , and those of
sRAGE tended to increase , in the
TGC group . -
pubmed
This study was performed to assess the efficacy of intradermal avotermin (
TGF - beta3 ) for the improvement of scar appearance following
scar revision surgery . -
pubmed
Laser - capture microdissection for
Factor VIII - expressing endothelial cells in
cancer tissues . -
pubmed
Reportedly ,
CD300f negatively regulates interactions between dendritic and T cells and acts as an anti - inflammatory molecule in a
multiple sclerosis mouse model . -
pubmed
The percentage of apoptotic cells in distal tubules found was : 3.02 % ( 1.03 - 5.00 % ) in
IGF , 1.66 % ( 0.92 - 2.39 % ) in
SGF , and 1.76 % ( 0.84 - 2.68 % ) in
DGF ; these differences were not significant . -
pubmed
Tissue - type plasminogen activator (
t - PA ) can modulate permeability of the neurovascular unit and exacerbate injury in
ischemic stroke . -
pubmed
SNP induced
nephrotoxicity by increasing serum
creatinine and blood
urea nitrogen ,
SNP significantly decreased
malate dehydrogenase ,
glucose-6 - phosphatase ,
fructose-1,6 - bisphosphatase and malic enzyme but increased
lactate dehydrogenase and
glucose-6 - phosphate dehydrogenase . -
pubmed
The activity of
catalase and
glutathione peroxidase decreased concomitantly with increased lipid peroxidation , indicating that the significant
kidney damage has been inflicted by
SNP . -
pubmed
Over the past two decades ,
heat shock proteins (
HSPs ) have been implicated in inflammatory responses and
autoimmunity . -
pubmed
The
immunoglobulin heavy - chain binding protein (
Bip)/
glucose - regulated protein 78 (
GRP78 ) ,
calnexin ,
calreticulin ,
glucose - regulated protein 94 (
GRP94)/
gp96 ,
oxygen regulated protein 150 (
ORP150)/
glucose - regulated protein 170 (
GRP170 ) ,
homocysteine - induced ER protein (
Herp ) and
heat shock protein 47 (
hsp47)/
Serpin H1 , which are expressed not only in the ER but also occasionally at the cell surface play pathophysiological roles in
autoimmune and inflammatory diseases as pro- or anti - inflammatory factors . -
pubmed
There was a significant increase in 3 - CT levels in both brain regions ( P<0.01 ) , whereas
aconitase activity was significantly decreased in
autism cerebellum ( P<0.01 ) , and was negatively correlated with
GSH /
GSSG ( P=0.01 ) . -
pubmed
Correlation between
IL-7 and
MCP-1 in
diabetic chronic non healing ulcer patients at higher risk of
coronary artery disease . -
pubmed
Cytokines play an extremely important role in the pathogenesis of
coronary artery disease (
CAD ) in which
interleukin ( IL )- 7 is a major regulator of T - cell homeostasis which is conced in the stimulation of leukocyte - endothelial cell adhesion during inflammatory events . -
pubmed
Circulating
IL-7 is associated with activation of monocyte and natural killer cells , leading to enhanced production of
inflammatory cytokines and
chemokines observed in
atherosclerosis and
acute coronary syndromes . -
pubmed
In conclusion the positive correlation between plasma concentration of
IL-7 ,
MCP-1 and hs -
CRP in
diabetic foot
patients observed herein , suggests a plausible role for
IL-7 in the promotion of clinical instability in
coronary artery disease . -
pubmed
Together they define a segmental
progeroid phenotype of the
Ercc1(-/
Delta7 )
mouse model . -
pubmed
Although
mastermind - like domain containing 1 (
MAMLD1 ) (
CXORF6 ) on
human chromosome Xq28 has been shown to be a causative gene for
46,XY disorders of sex development with
hypospadias , the biological function of
MAMLD1 /
Mamld1 remains to be elucidated . -
pubmed
Disappearance of Serum Methylated
p16 Indicates Longer Survival in Patients with
Gastric Cancer . -
pubmed
PURPOSE : The aim of this study was to assess clinical correlations with postoperative alteration of
p16 DNA methylation , and to clarify whether postoperative changes in the serum DNA methylation status of
p16 could be used as a reliable prognostic factor for
gastric cancer . -
pubmed
Whereas methylation of preoperative serum DNA was not correlated with survival ,
patients with postoperative disappearance of
p16 methylation showed longer survival than those without postoperative disappearance of
p16 methylation in the
patients who had
gastric cancer with lymph node metastasis ( P=0.042 ) . -
pubmed
CONCLUSIONS : Postoperative disappearance of
p16 methylation could be an available prognostic factor for node - positive
gastric cancer . -
pubmed
Units were assessed for
hemolysis ,
adenosine triphosphate (
ATP ) concentration , lipid composition , and RMP generation , as well as PS and
CD47 expression throughout 49 days of HS . -
pubmed
Accumulation of
FGF9 in
prostate cancer correlates with epithelial - to - mesenchymal transition and induction of
VEGF - A expression . -
pubmed
AIM : The aim of the present study was to investigate the molecular mechanism of
fibroblast growth factor ( FGF )- 9 in
prostate cancer cells . -
pubmed
CONCLUSION :
FGF9 can be associated with epithelial - to - mesenchymal transition and invasion by inducing
VEGF - A expression in
prostate cancer cells . -
pubmed
Comment on ' Strong reduction of
AGO2 expression in
melanoma and cellular consequences ' . -
pubmed
Of the 29
tumors that were diagnosed as
glioblastoma multiforme (
GBM ) , 11 had an OD component of which four showed codeletions of 1p and 19q ( 36.4 % ) and two
tumors showed
epidermal growth factor receptor (
EGFR ) amplification ( 20 % ) without 1p19q codeletions . -
pubmed
Amongst the remaining 18
GBMs without an OD component , three cases showed
EGFR amplification ( 16.7 % ) , one case showed isolated deletion of 1p and none showed 1p19q codeletions . -
pubmed
METHODS : This case study examined the effect of a 12 - week exercise and manual therapy intervention on morphology ,
pain , cardiopulmonary fitness , strength , neurological balance , immune markers (
CD4 cell count ) , and quality of life in a 43 - year - old
woman living with
HIV . -
pubmed
The treatments analysed were : antihypertensive treatments , statins , antiplatelet drugs ,
xanthine oxidase inhibitors , correction of
metabolic acidosis , treatment with (
calcium or non -
calcium )
phosphate binders ,
vitamin D (
calcitriol or
paricalcitol ) ,
erythropoietin and the availability of an
internal arteriovenous fistula (
IAVF ) . -
pubmed
In the multivariate models , we observed that , in addition to age , the comorbidity index ,
serum albumin , pre - dialysis treatment with
angiotensin - converting - enzyme inhibitors and/or
angiotensin receptor blockers , correction of
acidosis with
sodium bicarbonate and IAVF at the start of haemodialysis were significantly associated with better survival in dialysis . -
pubmed
Recently , naturally occurring genetic variants in both
beta2 integrins and
ICAMs are reported to be associated with
autoimmune disease . -
pubmed
Finally , toxin - driven
IL-1beta release supports the hypothesis that this
cytokine axis is a likely target for therapeutic intervention for
C. - pubmed
BACKGROUND AND OBJECTIVES :
Pegylated interferon (
peg - IFN )- alpha2a and - alpha2b show different pharmacokinetic properties but are used interchangeably for
hepatitis C treatment in traditional dual combinations and with newer agents . -
pubmed
METHODS :
Chronic hepatitis C patients treated with
ribavirin combined with
peg - IFN - alpha2a ( N = 109 ) or -alpha2b ( N = 114 ) were studied . -
pubmed
RESULTS :
Viraemia decline after 48/72 h and 7 days was significantly greater with peg -
IFN - alpha2b ( 1.96 and 2.12 vs 1.49 and 1.20 log10 IU / mL with peg -
IFN - alpha2a ; p & lt ; 0.001 ) . -
pubmed
Differences were of larger extent in
patients with advanced
fibrosis ( p = 0.002 ) , genotype 1 infection ( p = 0.002 ) and CT / TT genotypes of
IL28B ( p = 0.001 ) . -
pubmed
CONCLUSION : There are significant pharmacodynamic differences between peg -
IFN - alpha2a and - alpha2b in the early phase of
chronic hepatitis C treatment . -
pubmed
The proportion of patients who died from
cancer was the highest in the
calcium channel blocker ( CCB ) group ( 6.5 % ) , followed by
thiazide diuretics ( 4.4 % ) ,
angiotensin converting enzyme inhibitors ( 4.2 % ) and beta - blockers ( 2.6 % ) . -
pubmed
BACKGROUND :
Hypersensitivity reactions to anaesthetic agents are rare but often severe , with a mortality ranging from 4 to 9 % in
IgE - mediated events . -
pubmed
Severe reactions were associated with older age ( p = 0.025 ) ,
asthma ( p = 0.042 ) , history of
hypertension ( p = 0.001 ) , intake of serum
angiotensin converting enzyme inhibitor medication ( p = 0.012 ) or
serum angiotensin II antagonist ( p = 0.033 ) , higher levels of basal
tryptase ( p = 0.0211 ) . -
pubmed
Cardiovascular symptoms ( p = 0.006 ) and history of
hypersensitivity to antibiotics ( p = 0.029 ) were more frequently reported in
IgE - mediated reactions . -
pubmed
Our study therefore aimed to analyze the clinical manifestations and patterns of
cerebral atrophy ,
amyloid beta deposition and regional
glucose metabolism in Chinese
PCA patients , comparing them directly with those of typical
Alzheimer ' s disease (
TAD ) . -
pubmed
Population - weighted , logistic models estimated how strongly each anthropometric indicator was associated with 5
cardiometabolic disorders :
Dysglycemia (
glycated hemoglobin & gt;=5.7 % ) , HyperNonHDLc ( non - high - density - lipoprotein [
HDL ]
cholesterol & gt;=4.14 mmol / L , or taking anticholesteremic medications ) ,
Hypertension ( systolic blood pressure & gt;=140 mm Hg or diastolic blood pressure & gt;=90 mm Hg , or taking antihypertensive medications ) , HyperALT (
alanine transaminase & gt;=
p75 [ 75th percentile , sex - specific ] ) , and
HyperGGT (
gamma - glutamyltransferase & gt;=
p75 [ sex - specific ] ) . -
pubmed
Included are a review of the potential applications of
IgY in the control of
enteric infections of either bacterial or viral origin such as enterotoxigenic
Escherichia coli ,
Salmonella spp . -
pubmed
Sex - specific
troponin measures for diagnosis of
acute coronary syndrome . -
pubmed
Gut Microbial Membership Modulates
CD4 T Cell Reconstitution and Function after
Sepsis . -
pubmed
Toxascaris leonina galectin (
Tl - gal ) is a
galectin-9 homologue protein isolated from an adult worm of the
canine gastrointestinal nematode parasite , and Tl - gal - vaccinated challenge can inhibit inflammation in
inflammatory bowel disease - induced
mice . -
pubmed
RESULTS : Our analysis revealed the lack of clinically relevant interactions between preparations of
levodopa and
benserazide ( used for the treatment of
PD ) and
angiotensin - converting enzyme inhibitors , antagonists of
AT1 receptor for
angiotensin II or antagonists of
beta - adrenoreceptors ( beta - adrenolytics ) . -
pubmed
The anti -
convulsive effects of the natural product
quinine may - at least in part - be explained by interaction with
SV2A. -
pubmed
The role of
antithrombin in
patients with
toxic epidermal necrolysis . -
pubmed
BACKGROUND :
Prostate - specific membrane antigen positron emission tomography / computed tomography ( PSMAPET / CT ) is a new and evolving diagnostic method in
prostate cancer with special impact on treatment planning in image - guided radiotherapy ( IGRT ) . -
pubmed
CONCLUSIONS : Preliminary results of this study show high metabolic response rates of
PSMA PET - positive
metastatic lesions after hypofractionated radiotherapy in follow - up PSMA PET with promising local control rates . -
pubmed
PURPOSE : The aims of this study were to develop a population pharmacokinetic ( PPK ) model of
lamotrigine (
LTG ) in Chinese
epileptic children by using nonlinear mixed effects modeling ( NONMEM ) and to investigate the effects of
valproic acid (
VPA ) and genetic polymorphisms of the major metabolizing enzymes (
UGT1A4 ,
UGT2B7 ) on the pharmacokinetics of
LTG . -
pubmed
The expressions of the leaf - abundant isoforms ,
HbMT2 and - 3L were up - regulated following pathogenic
fungus infection and high - temperature stress , but down - regulated by low - temperature stress . -
pubmed
The
BRCA1 -
PALB2 -
BRCA2 axis plays an essential role in DNA homologous recombination repair , defect in which drives genome instability and
cancer development . -
pubmed
Following ionizing radiation , the mutant
mice displayed higher levels of DNA breaks and stronger induction of
p53 and
p21 , but continued DNA synthesis , reduced apoptosis , and accelerated
tumor development . -
pubmed
The differences in
p21 induction , DNA synthesis , and apoptosis between wild - type and mutant
mice were substantially more pronounced in the mammary gland than in the intestine , suggesting a potential contributing factor to the increased risk and the tissue specificity of
BRCA /
PALB2 - associated
tumor development . -
pubmed
Treatment of the mutant
mice with an inhibitor of
NF - kappaB reactivated apoptosis and delayed
tumor development following radiation . -
pubmed
YAP Tyrosine Phosphorylation and Nuclear Localization in
Cholangiocarcinoma Cells Are Regulated by
LCK and Independent of
LATS Activity . -
pubmed
The Hippo pathway effector ,
Yes - associated protein (
YAP ) , is a transcriptional coactivator implicated in
cholangiocarcinoma (
CCA ) pathogenesis . -
pubmed
The importance of
LCK in CCA biology was demonstrated by clinical observations suggesting
LCK expression levels were associated with early
tumor recurrence following resection of
CCA . -
pubmed
The hsa_circ_0044235 in peripheral blood from
RA patients did not correlate with
C - reactive protein (
CRP ) , erythrocyte sedimentation rate ( ESR ) ,
rheumatoid factor (
RF ) , anti - citrullinated protein antibodies (
ACPA ) or disease activity score 28 ( DAS28 ) . -
pubmed
, c.416T>C ( p. Phe139Ser ) in
SORD , c.1048_1049delGCinsCG ( p. Ala350Arg ) in
KRT6A , c.1159G>T ( p. Gly387Cys ) in
SVEP1 , and c.430G>C ( p. Gly144Arg ) in
MRPL38 as a critical genetic factor for
liver cancer . -
pubmed
Advanced
Yeast Models of
Familial Alzheimer Disease Expressing
FAD - Linked
Presenilin to Screen Mutations and
gamma - Secretase Modulators . -
pubmed
APP is cleaved by
gamma - secretase to produce
amyloid beta peptide (
Abeta ) , which is deposited in the brains of
Alzheimer disease patients . -
pubmed
By studying the loss - of - function properties of
PS1 mutants , it is possible to successfully screen FAD suppressor mutations and identify
gamma - secretase modulators ( GSMs ) , which are promising
Alzheimer disease therapeutic agents . -
pubmed
Morphine , which acts through
opioid receptors , is one of the most efficient analgesics for the alleviation of severe
pain . -
pubmed
Regulatory T cell is critical for
interleukin-33 - mediated neuroprotection against
stroke . -
pubmed
Interleukin-33 (
IL-33 ) is known to activate the regulatory T lymphocytes ( Tregs ) , which are negatively correlated with
brain damage after
ischemic stroke . -
pubmed
In vivo , male
C57BL / 6 N mice were subjected to 60 min of transient
middle cerebral artery occlusion (
tMCAO ) , followed by daily administration of vehicle or
IL-33 immediately after
injury . -
pubmed
Behavioral changes ,
brain edema ,
neuronal injury , Treg percentages , and
cytokine expression levels were investigated in each group . -
pubmed
The results indicate that intraperitoneal administration of anti -
CD25Ab reduced
CD4 +
CD25 +
Foxp3 + Tregs , increased infarct volume , enhanced
stroke - induced cell death , and decreased sensorimotor functions . -
pubmed
Overall , these findings showed that
IL-33 afforded neuroprotection against
ischemic brain injury by enhancing
ST2 - dependent regulatory T - cell expansion and activation via a mechanism involving anti - apoptosis proteins and
cytokines , representing a promising immune modulatory target for the treatment of
stroke . -
pubmed
The evaluation of
Ptk7 transcripts in the thymus , for its part , showed a decrease in expression , especially following an
infection at day 10 of gestation , which supports the hypothesis of T cell accumulation in a mature stage in the thymus . -
pubmed
PAX 8 - positive
sarcomatoid carcinoma arising from the liver with aggressive phenotype : An autopsy case . -
pubmed
Accordingly , the ongoing medical examinations and the autopsy reports of the deceased individuals indicate that organs / tissues with high expression levels of
ACE2 ,
TMPRSS2 and other putative viral entry - associated genes are most vulnerable to the
infection . -
pubmed
Furthermore , expression , structural and docking analyses of
ACE2 revealed the potential risk of
olfactory dysfunction in four additional
mammalian species , revealing an evolutionarily conserved
infection susceptibility . -
pubmed
Epidermal Growth Factor Receptor and its Oncogenic
EGFRvIII Variant in Benign and
Malignant Brain Tumors . -
pubmed
BACKGROUND / AIM : Tumorigenesis and
cancer progression might be driven by abnormal activation of
growth factor receptors . -
pubmed
Importantly , molecular changes in
EGFR - dependent signaling is one of the most common characteristics of
brain tumors . -
pubmed
PATIENTS AND METHODS :
HER1 and
EGFRvIII variants in
meningiomas and
glioblastomas were evaluated at the RNA level . -
pubmed
RESULTS :
EGFRvIII was found in 18.6 % of
glioblastomas (
GBM ) , whereas 25 % of
EGFRvIII positive tumors express wild - type
EGFR as well . -
pubmed
HER1 was over - expressed in benign
meningiomas compared to
glioblastomas , whereas
HER1 expression in
meningiomas differed significantly between sub - types of
meningiomas . -
pubmed
EGFRvIII and
HER1 where positively correlated in
glioblastomas . -
pubmed
Yet , the
patient overall survival did not differ between high- and low -
HER1 expressing
glioblastomas or between
EGFRvIII positive and negative
GBMs . -
pubmed
CONCLUSION :
HER1 may be considered as an independent factor for classification of
benign meningiomas . -
pubmed
The mRNA levels of
HER1 or
EGFRvIII should not be used as independent prognostic factors for
patients with
gliomas . -
pubmed
Hormone receptors in
breast cancer and response to chemotherapy . -
pubmed
Serum immunoglobulins in
patients with
schistosomiasis mansoni . -
pubmed
The authors evaluated
immunglobulins IgA ,
IgC and
IgM in two groups of
schistosomiasis patients , 20 presenting the hepato - intestinal form (
HI ) and 20 the hepatosplenic form (
HS ) . -
pubmed
Hyperparathyroidism developed in 13 of 15
patients with serum
parathormone levels greater than 500 but in only six of 56
patients with values less than 500 . -
pubmed
Progressive
bone disease and elevated
serum parathormone levels are the most important indicators . -
pubmed
Our data suggest that
indoleamine-2,3 - dioxygenase (
IDO ) , the rate limiting enzyme of the
kynurenine pathway of
L - tryptophan metabolism , was activated in both syndromes by
cytokines including
IFN - gamma , and that perhaps products of
tryptophan metabolism played a role in the pathogenesis of
EMS and
TOS . -
pubmed
[ Clinical significance of
serum ferritin and acute phase reactant proteins levels in
patients with
cervical cancer ] . -
pubmed
Serum ferritin (
SF ) levels from 162
patients with
cervical cancer and their serum
alpha 1 - acid glycoprotein (
alpha 1 - AGP ) . -
pubmed
The result showed that concentration of
SF ,
alpha 1 - AGP ,
alpha 1 - AT were significantly higher , while
TF significantly lower in
cervical carcinoma patients during active period than from
patients with benign
tumors and normal
persons . -
pubmed
The positive rate of
SF ,
alpha 1 - AGP and
Tf in
cervical cancer patients during active period was significantly higher than that of
alpha 1 - AT . -
pubmed
All had
chronic hepatitis , on biopsy , and were positive for
HBcAg on hepatocytes . -
pubmed
A second liver biopsy was available in 15 patients , and
HBcAg was negative in all ; histology was normal in eight , unchanged in one , and compatible with
cirrhosis in six . -
pubmed
The same
IgE- and
IgG - rich fractions induced eosinophil - mediated
cytotoxicity of live schistosomula in vitro . -
pubmed
The proportions of
alpha 1AT to
ALP vary in
patients with
alpha 1AT deficiency ( 1:9 ) , established
emphysema ( 1:1 ) and subjects with healthy lungs ( 10:1 ) . -
pubmed
The
hyperthermia elicited by a subcutaneous ( sc ) injection of 8 mg / kg
morphine to freely moving
rats was not diminished by
CCK pretreatment . -
pubmed
CCK ( 5 micrograms / kp ip ) completely prevented the restraint stress - induced
hyperthermia . -
pubmed
The role of complement and
protease systems in development of
tissue injury are also discussed . -
pubmed
FVIII RAg and
FVIII Rcof were both significantly elevated in
diabetes mellitus . -
pubmed
The
FVIII RAg release ( delta
FVIII RAg ) was significantly less in the
diabetics . -
pubmed
Fibrinolytic activity ,
FVIII RAg and
FVIII Rcof are independent of the degree of metabolic control in
patients with
diabetes . -
pubmed
[ Cyclic elevation of
HbF in a case of
Blackfan - Diamond disease . -
pubmed
Preoiperative
carcinoembryonic antigen level and prognosis in
colorectal cancer . -
pubmed
Carcinoembryonic antigen (
CEA ) levels were estimated in 117
patients before resection of
colorectal cancer . -
pubmed
CEA values rose progressively with
tumour stages , and were higher in
patients with
liver metastases compared with
patients with only lymph - node spread . -
pubmed
A single preoperative
CEA estimation does not add to the prognostic information available from careful assessment of the stage of
tumour spread . -
pubmed
Measurement of chromosomal aberrations , sister chromatid exchange ,
hprt mutations , and DNA adducts in peripheral lymphocytes of
human populations at increased risk for
cancer . -
pubmed
Sister chromatid exchanges ( SCE ) and
polycyclic aromatic hydrocarbon (
PAH)-DNA adducts were evaluated in a group of firefighters ; chromosomal aberrations and
hprt mutations were evaluated in a group of
cancer patients undergoing radioimmunoglobulin therapy ( RIT ) ;
SCE and
acrolein - modified DNA were measured in
cancer chemotherapy patients and in pharmacists preparing chemotherapy prescriptions ; and SCE and
PAH - DNA adducts are being measured in U.S. army troops stationed in Kuwait . -
pubmed
Familial hypobetalipoproteinemia represents a heterogeneous group of
genetic defects in which the concentrations of plasma
apolipoprotein B and
apo - B - containing lipoproteins
VLDL and
LDL are abnormally low . -
pubmed
In one family , heterozygotes had very low
apo B levels and their major
HDL subfraction was
HDL2 as in
abetalipoproteinemia , whereas in the second family heterozygotes had
apo B levels approximately half on normal and the major
HDL subfraction was
HDL3 with an
HDL elution pattern intermediate between that observed in
abetalipoproteinemia and normal subjects . -
pubmed
Cytoplasmic markers of potential malignancy have been examined and , of these ,
keratins ,
filaggrin , and some
carcinoma antigens show most promise . -
pubmed
Low expression of the
Lsp1 gene in early
mouse T - lymphomas induced by
N - methyl - N - nitrosourea . -
pubmed
To determine whether the down - regulation of
LSP1 expression is an early event which occurs in vivo in the
tumor , rather than as a consequence of in vitro propagation of
T - lymphoma cells , we analyzed
LSP1 expression in primary
T - lymphomas induced in AKR / J or AKR / J x BALB / cJ
mice by a single intraperitoneal ( i.p . ) -
pubmed
Two- color Fluorescence Activated Cell Sorter ( FACS ) analysis showed that all
tumors had an immature
CD4+/
CD8 + double positive ( DP ) phenotype . -
pubmed
Since these cells may be infiltrating lymphocytes which can be expected to express the
Lsp1 gene at a high level these
tumors were not included in our analysis . -
pubmed
Nineteen
tumors were analyzed for
Lsp1 gene expression and 13 contained reduced levels of
LSP1 RNA , ranging from 4 % to 44 % of those found in age - matched normal thymus . -
pubmed
Six
tumors showed either no or only a small reduction in
LSP1 RNA . -
pubmed
These
tumors had developed later than those expressing low levels of
LSP1 . -
pubmed
The level of
LSP1 RNA in
tumors developing & lt;110 days after injection of
MNU was 19.1 % + /- 5.2 ( mean + /- SEM ) , while the level of
LSP1 in later
tumors was 78.4 % + /- 13.0 ( P = 0.004 ) . -
pubmed
Second , they show that down - regulation of the
Lsp1 gene in transformed T - cells is not the result of prolonged in vitro culture , but occurs in the majority of primary
tumors . -
pubmed
Third , they show that there are two classes of
T - lymphoma , which differ in their expression of
LSP1 RNA and that the down - regulation of
LSP1 is specifically associated with the early appearance of
T - lymphoma after injection with
MNU . -
pubmed
In
man ,
iNOS immunoreactivity was also primarily localized in macrophages on the seventh day following death from
myocardial infarction . -
pubmed
Inhibitory
H3 receptors on sympathetic nerves of the pithed
rat : activation by endogenous
histamine and operation in spontaneously
hypertensive rats . -
pubmed
Two
H3 receptor agonists ,
R -(-)- alpha - methylhistamine and
imetit , inhibited the electrically induced
increase in diastolic blood pressure in a dose - dependent manner . -
pubmed
Moreover , it demonstrates that these
H3 receptors are probably activated by endogenous
histamine and appear to be operative in
hypertension . -
pubmed
Results also suggested that
AIDS patients base treatment decisions primarily on the likelihood of raising
CD4 + cell counts and restrictiveness of dosing regimens , but are not influenced by FDA approval status , volume of empirical support for the medications , or even possible harmful side effects . -
pubmed
Such
metabolic anomaly would be responsible for the alterations in both the skin barrier function and in the Th2 inflammatory reactions in part mediated through
IgE. -
pubmed
Genetic heterogeneity of the 5 ' uncoding region of the
catalase gene in Hungarian acatalasemic and
hypocatalasemic subjects . -
pubmed
None of these mutations may be the causal mutation(s ) of
acatalasemia as each of these nucleotide substitutions were detected in healthy subjects with normal blood
catalase activity . -
pubmed
BACKGROUND : This study evaluates whether a new analytic principle , processing - independent analysis ( PIA ) , offers better specificity and sensitivity than the conventional
gastrin radioimmunoassay in the diagnosis of
gastrinomas . -
pubmed
METHODS : Plasma concentrations of
alpha - amidated gastrins and the total
progastrin product were measured with radioimmunoassay and with PIA , respectively , in 512 samples taken for
gastrin measurement and in a selected group of
gastrinoma patients ( n=10 ) . -
pubmed
CONCLUSIONS : In screening for
gastrinomas PIA offered no diagnostic advantages in comparison with conventional
gastrin radioimmunoassay . -
pubmed
However , in selected
patients who in spite of normal or slightly increased concentrations of amidated gastrins were still suspected of having
gastrinoma , additional measurement of the total
progastrin product showed incomplete processing of
progastrin and thus proved helpful in establishing the diagnosis . -
pubmed
In this study , the effect of the
angiotensin - converting - enzyme inhibitor (
ACE inhibitor )
Ramipril ( 5 mg / day ) and
calcium antagonist
Isradipin ( 5 mg / day ) treatment of two groups of
hypertensive patients ( n = 22 in each of group ) was evaluated . -
pubmed
In conclusion ,
ACE inhibition with
Ramipril and
calcium channel blocking with
Isradipin lead to a moderate improvement of blood rheology in
patients with
hypertension . -
pubmed
These data suggest that immunological differences , depending on
cytokine gene polymorphisms , regulate the resistance to
EBV infection . -
pubmed
,
cyclin B1 ,
cyclin D1 ,
cdk4 , and
PCNA , in
rat brain after transient
MCA occlusion , and compared the temporal profile of the results with that of TUNEL study , which detects double strand breaks in DNA . -
pubmed
There were no immunoreactivities for
cyclin B1 ,
cyclin D1 , and
PCNA in the brain with and without
ischemia . -
pubmed
As for
cdk4 , however , it became present at 1 and 3 days of reperfusion after 2 h of
ischemia . -
pubmed
These results indicate that aberrant expression of
cdk4 , but not
cyclin B1 ,
cyclin D1 or
PCNA , actually takes place in the brain after MCA occlusion , but this is not the causative mechanism of apoptotic cell death in the brain with
ischemia . -
pubmed
Combined highly active anti - retroviral therapy ( HAART ) with protease and
reverse transcriptase inhibitors has modified the natural history of
opportunistic infections and
neoplasms in
human immunodeficiency virus ( HIV )- infected patients . -
pubmed
The ELISAs based on the
rNP50s of
HTNV ,
SEOV , and
DOBV successfully differentiated three groups of patient sera , previously defined by neutralization tests : 17 with
HTNV infection , 12 with
SEOV infection , and 20 with
DOBV infection . -
pubmed
The entire
rNP of
Puumala virus (
PUUV ) distinguished
PUUV infection from the other types of
hantavirus infection . -
pubmed
HIV-1 infection induces alteration of cellular lipids : ( 1 ) shift in phospholipid synthesis to neutral lipids associated with the viral load ,
polyunsaturated fatty acid (
PUFA ) peroxidation , and n-3 deficiency with deregulation of
cytokines and
PPAR - gamma (
peroxisome proliferator - activated receptor - gamma ) , and ( 2 ) alloimmune phospholipid antibody production in which antibodies to cardiolipin and to
phosphatidylserine are most prevalent , due to the destruction of mitochondrial membranes and progression of lymphocyte apoptosis . -
pubmed
LD syndrome appears to be induced by PIs that inhibit
GLUT4 ,
glucose transporter isoform , and by NRTIs which provoke
mitochondrial failure . -
pubmed
RESULTS : The median level of urinary
iodide of the sample subjects was 614.61 micrograms / L. The prevalence of clinical and subclinical
hyperthyroidism was 1.21 % and 1.12 % respectively ; 92.3 % of the clinical
hyperthyroidism were of
Graves ' disease and 75 % of the subjects with subclinical
hypothyroidism were
TRAb positive . -
pubmed
The
ErbB receptor family : a therapeutic target for
cancer . -
pubmed
This article reviews the current state of efforts targeting the
ErbB family of
tyrosine kinase receptors in
cancer therapy . -
pubmed
Influence of the
endothelial nitric oxide synthase polymorphism on the progression of
autosomal dominant polycystic kidney disease and
IgA nephropathy . -
pubmed
Our study tried to verify the hypothesis that
endothelial nitric oxide synthase (
ecNOS ) gene polymorphisms in intron 4 could have some relevance to the progression of
ADPKD and/or
IgA nephropathy . -
pubmed
The frequencies of
ecNOSa / b + a / a and
ecNOSb / b genotypes in
ADPKD patients were : 26.6 % ( 8/30 ) and 73.4 % ( 22/30 ) in
ADPKD patients with normal renal function , 30 % ( 9/30 ) and 70 % ( 21/30 ) in
ADPKD with
ESRF , 35.2 % ( 18/51 ) and 64.8 % ( 33/51 ) in young
ADPKD patients , 60 % ( 12/20 ) and 40 % ( 8/20 ) in
ADPKD patients with
ESRF later than in 62 years . -
pubmed
In
IGAN , the frequencies of
ecNOSa /
b + a / a and
ecNOSb / b genotypes were 24 % ( 12/50 ) and 76 % ( 38/50 ) in
IgA with normal renal function and 20.9 % ( 9/43 ) and 79.1 % ( 38/43 ) in
IgA with
ESRF . -
pubmed
CONCLUSION : Both in
ADPKD and
IGAN groups , there was no significant difference in the frequencies of
ecNOS genotypes between patients with normal renal function and age matched patients with
ESRF and between patients with normal renal function and control group . -
pubmed
The frequency of
ecNOSa allele was significantly higher in a number limited group
ADPKD patients with
ESRF later than in 62 years ( Chi - square test p & lt ; 0.05 ) . -
pubmed
However after 12 weeks treatment in participants with moderate to severe
lung disease compared to
DNase , HS 5mls twice a day showed less benefit to FEV1 , WMD -13.00 ( 95%CI -22.46 to -3.54 ) . -
pubmed
Apolipoprotein E epsilon4 allele ,
AD pathology , and the clinical expression of
Alzheimer ' s disease . -
pubmed
OBJECTIVE : To test the hypothesis that the
APOE epsilon4 allele is associated with the clinical manifestations of
AD through an association with the pathologic hallmarks of disease . -
pubmed
CONCLUSIONS : The
APOE epsilon4 allele appears to be associated with the clinical manifestations of
AD through an association with the pathologic hallmarks of
AD rather than another mechanism . -
pubmed
Support for this hypothesis comes from studies in
adenosine - deaminase - deficient
mice where lung
adenosine levels accumulate in association with increased
lung inflammation and damage . -
pubmed
Furthermore , lowering
adenosine levels or antagonizing
adenosine receptors can reverse pulmonary phenotypes in this model , suggesting that chronic
adenosine elevations can affect signaling pathways that mediate aspects of
chronic lung disease . -
pubmed
These data provide further evidence that environmental pollutants can influence
allergic inflammation through enhanced
Fc epsilon RI - coupled mediator release from
human basophils . -
pubmed
The immunopathogenesis of demyelination in
multiple sclerosis involves an autoantibody response to
myelin oligodendrocyte glycoprotein (
MOG ) , a type I transmembrane protein located at the surface of CNS myelin . -
pubmed
Most VPM - projecting neurons examined did not show
Fos - like immunoreactivity after
masseter inflammation . -
pubmed
Serum amyloid A ,
C - reactive protein and
remnant - like lipoprotein particle
cholesterol in
type 2 diabetic patients with
coronary heart disease . -
pubmed
BACKGROUND :
Serum amyloid A (
SAA ) and
C - reactive protein (
CRP ) have been suggested to be involved in the process of
coronary heart disease (
CHD ) and to be potential markers and/or predictors of
CHD . -
pubmed
Remnant - like lipoprotein particles ( RLPs ) , which are regarded as atherogenic remnant lipoprotein , are reported to be increased in
type 2 diabetic patients . -
pubmed
We assessed the association of
CHD with
SAA ,
CRP and
RLP - cholesterol in
type 2 diabetic patients . -
pubmed
RESULTS : The mean standard deviation values of
RLP - cholesterol in
patients with and without
CHD were 0.22 ( 0.26 ) mmol / L and 0.15 ( 0.10 ) mmol / L , respectively ( P & lt;0.05 ) . -
pubmed
Median ( interquartile ranges ) for
SAA in
patients with and without
CHD were 7.4 ( 4.2 - 11.2 ) mg / L and 3.9 ( 2.2 - 5.9 ) mg / L , respectively ( P & lt;0.001 ) . -
pubmed
Median ( interquartile ranges ) for
CRP in
patients with and without
CHD was 1.14 ( 0.45 - 2.08 ) mg / L and 0.43 ( 0.19 - 1.25 ) mg / L , respectively ( P & lt;0.001 ) . -
pubmed
CONCLUSION : These data suggest that
SAA ,
CRP and
RLP - cholesterol are increased in
type 2 diabetic patients with
CHD , and that the inflammatory proteins correlate with remnant lipoprotein . -
pubmed
We observed these
patients for 28.5 + /- 12.8 ( mean + /- SD ; range 12 - 53 ) months after transient
thyrotoxicosis , and measured
TSH , FT4 , and
TSH binding inhibitor immunoglobulin in sera . -
pubmed
Life - threatening adverse reaction followed by
thrombocytopenia after passive transfusion of fresh frozen plasma containing anti -
CD36 (
Nak ) isoantibody . -
pubmed
BACKGROUND : Anti -
CD36 isoantibody in blood recipients is reported to cause refractoriness to platelet ( PLT ) transfusions and posttransfusion
purpura - like syndrome . -
pubmed
CONCLUSION : This is the first reported case of life - threatening adverse effects and
thrombocytopenia caused by passively transfused anti -
CD36 isoantibody . -
pubmed
A novel small molecule
CFTR inhibitor attenuates
HCO3 - secretion and duodenal
ulcer formation in
rats . -
pubmed
To further test this hypothesis , we examined the effect of a novel , potent , and highly selective
CFTR inhibitor ,
CFTR ( inh )- 172 , on DBS and
duodenal ulceration in
rats . -
pubmed
Duodenal
ulcers were observed 24 h after
cysteamine treatment but were reduced in
CFTR(inh)-172 - pretreated
rats . -
pubmed
CFTR(inh)-172 acutely produces
CFTR dysfunction in
rodents for up to 24 h.
CFTR inhibition reduces acid - induced DBS but also prevents duodenal
ulcer formation , supporting our hypothesis that intracellular
HCO ( 3 )(- ) may be an important protective mechanism for duodenal epithelial cells . -
pubmed
In this review , we report the most up - dated findings about nuclear
PI - PLC - beta1 , such as the localization in nuclear speckles , the activity changes during the cell cycle phases , and the possible involvement in the progression of
myelodisplastic syndrome to
acute myeloid leukemia . -
pubmed
Sex - specific association of
PTPN22 1858 T with
type 1 diabetes but not with
Hashimoto ' s thyroiditis or
Addison ' s disease in the German population . -
pubmed
BACKGROUND :
Endocrine autoimmune disorders share genetic susceptibility loci , causing a disordered T - cell activation and homeostasis (
HLA class II genes ,
CTLA-4 ) . -
pubmed
MATERIALS AND METHODS :
Patients with
type 1 diabetes ( n = 220 ) ,
Hashimoto ' s thyroiditis ( n = 94 ) ,
Addison ' s disease ( n = 121 ) and healthy controls ( n = 239 ) were genotyped for the gene polymorphism
PTPN22 1858 C / T. RESULTS : Our study confirms a significant association between allelic variation of the
PTPN22 1858 C / T polymorphism and
type 1 diabetes mellitus (
T1D ) . -
pubmed
No significant difference was observed between the distribution of
PTPN22 C / T in patients with
Hashimoto ' s thyroiditis or
Addison ' s disease and healthy controls . -
pubmed
CONCLUSION : The
PTPN22 polymorphism 1858 C / T may be involved in the pathogenesis of
type 1 diabetes mellitus by a sex - specific mechanism that contributes to susceptibility in females . -
pubmed
Rates of
hypertension , high
low density lipoprotein (
LDL )
cholesterol , and
diabetes mellitus awareness , treatment , and control for persons with a history of
myocardial infarction and
stroke were compared by using two nationally representative samples of the US population : the Third National Health and Nutrition Examination Survey in 1988 - 1994 ( n = 1,004 ) and the National Health and Nutrition Examination Survey in 1999 - 2002 ( n = 512 ) . -
pubmed
Among such survivors , awareness of a previous diagnosis of
hypertension and prevalence of self - reported
diabetes mellitus remained stable while awareness of high
LDL cholesterol increased from 43.3 % to 60.2 % ( p & lt ; 0.01 ) . -
pubmed
Among those aware of their diagnosis , pharmacologic treatment for high
LDL cholesterol increased from 33.1 % to 78.4 % and pharmacologic treatment for
diabetes mellitus increased from 80.0 % to 93.6 % during this time ( each p & lt ; 0.01 ) , while pharmacologic treatment for
hypertension increased nonsignificantly . -
pubmed
Among those receiving pharmacologic treatment ,
hypertension and high
LDL cholesterol control increased from 48.9 % to 59.3 % ( p = 0.05 ) and from 5.1 % to 33.1 % ( p & lt ; 0.01 ) , respectively . -
pubmed
The number of US
myocardial infarction and
stroke survivors increased between 1988 - 1994 and 1999 - 2002 , and substantial improvements occurred in the awareness , treatment , and control of high
LDL cholesterol in this population . -
pubmed
Crystal - storing histiocytosis (
CSH ) is a rare disorder characterized by accumulation of
immunoglobulin light chain within histiocytes in one or more organ systems , typically in association with
multiple myeloma or , less frequently , with other conditions such as
lymphoplasmacytic lymphoma , the use of certain medications , or even
polyclonal gammopathies . -
pubmed
Of serum samples collected from the first 19 patients ,
Rift Valley fever ( RVF ) virus RNA or
immunoglobulin M (
IgM ) antibodies against
RVF virus were found in samples from 10 patients ; all serum specimens were negative for yellow fever , Ebola ,
Crimean - Congo hemorrhagic fever , and
dengue viruses . -
pubmed
Effect of targeted magnetic nanoparticles containing
5 - FU on expression of
bcl-2 ,
bax and
caspase 3 in
nude mice with transplanted
human liver cancer . -
pubmed
Tumor tissues were isolated for examination of the expression of
bcl-2 ,
bax and
caspase 3 by immunohistochemical method , reverse transcription polymerase chain reaction and Western blotting . -
pubmed
CONCLUSION : The targeted magnetic nanoparticles containing
5 - FU can improve the chemotherapeutic effect of
5 - FU against
hepatocellular carcinoma by decreasing the expression of bcl-2 gene , and increasing the expression of
bax and
caspase 3 genes . -
pubmed
METHODS : Ninety - nine
youth aged 7 - 17 yr with
T2DM had a fasting blood sample for lipid and lipoprotein levels [ total
cholesterol ,
low - density lipoprotein cholesterol (
LDL - c ) ,
high - density lipoprotein cholesterol ,
triglycerides ( TG ) ] ,
apolipoprotein B (
apoB ) , blood
glucose , and
hemoglobin A1c (
HbA1(C ) ) . -
pubmed
ApoB levels exceeded the 75th % ile of the control population in 72 % of those with
T2DM . -
pubmed
Thirty - seven percent of those with
T2DM had elevated TG and
apoB levels . -
pubmed
Elevated
apoB levels with normal
LDL - c levels highlight the importance of a full lipid panel including
apoB in defining potential modifiable cardiovascular risk in this population with high rates of
obesity , smoking , and poor glycemic control . -
pubmed
A combined chemotherapy regimen comprising
fludarabine ,
cytosine arabinoside , and
granulocyte colony - stimulating factor (
FLAG ) has been used in the treatment of relapsed or
refractory leukemias . -
pubmed
Human trehalase (
TREH ) is expressed in the intestine and kidney and probably hydrolyzes ingested
trehalose in the intestine and acts as marker of
renal tubular damage in kidney . -
pubmed
Neuronal death produced by
cerebral ischemia activates innate immunity by
Toll - like receptors and triggers inflammatory response . -
pubmed
Molecular characterization and prognostic significance of
FLT3 in
CML progression . -
pubmed
The induction of
FLT3 in
CML cells attenuated
imatinib - induced apoptosis . -
pubmed
OBJECTIVE : The primary objective was to study the epidemiology of
Human Immunodeficiency Virus ( HIV ) positive tribal patients , and the secondary objective was to study the associated comorbidities in a tertiary care hospital in the tribal ( Bastar ) region of Chhattisgarh , India , between December 2006 and November 2008 , and their relation to
CD4 counts . -
pubmed
As a consequence , levels of CS - induced
tumor necrosis factor - alpha and
nitric oxide synthase , markers of
inflammation , and
8 - hydroxy-2 - deoxyguanosine , a marker of DNA oxidation , were elevated in the aged
mice compared with the young
mice . -
pubmed
CONCLUSION : The protective effect of BHR on renal function in
rats with
GS is possibly by way of influencing expressions of
TGF - beta1 ,
TIMP-1 and
MMP1 to regulate the state of extracellular matrix and lessen the matrix aggregation . -
pubmed
The expression of
TLRs in the CNS is variable and can be modulated by multiple factors , including pro - inflammatory molecules , which are elevated in
neurodegenerative diseases and can increase the expression of
TLRs in CNS cells . -
pubmed
Therefore ,
TLRs have been shown to play a role in several aspects of
neurodegenerative diseases . -
pubmed
Here we will discuss results reported in the recent literature concerning the participation of
TLRs in
neurodegenerative diseases . -
pubmed
In the media layer , Sv([
Fbn-1 ] ) was 12,5 % greater in veins from women without
edema and apoptosis was more detected in the veins from
patients with
edema . -
pubmed
The current interest in developing
Glycine transporter Type 1 (
GlyT-1 ) inhibitors , for diseases such as
schizophrenia , has led to the demand for a
GlyT-1 PET molecular imaging tool to aid drug development and dose selection . -
pubmed
The orphan nuclear receptor
LRH-1 and
ERalpha activate
GREB1 expression to induce
breast cancer cell proliferation . -
pubmed
BACKGROUND :
Liver Receptor Homolog 1 (
LRH-1 ,
NR5A2 ) is an orphan nuclear receptor that is over - expressed in
cancers in tissues such as the breast , colon and pancreas . -
pubmed
In
tumor cells ,
LRH-1 induces proliferation and cell cycle progression . -
pubmed
High
LRH-1 expression is demonstrated in
breast cancers , positively correlating with
ERalpha status and
aromatase activity . -
pubmed
LRH-1 dependent cellular mechanisms in
breast cancer epithelial cells are poorly defined . -
pubmed
Hence in the present study we investigated the actions of
LRH-1 in
estrogen receptor alpha (
ERalpha ) positive
breast cancer cells . -
pubmed
RESULTS : The study aimed to investigate
LRH-1 dependent mechanisms that promote
breast cancer proliferation . -
pubmed
LRH-1 and
ERalpha co - operatively activated transcription of ERE
luciferase reporter constructs suggesting an overlap in regulation of target genes in
breast cancer cells . -
pubmed
CONCLUSIONS : We conclude that in
ER - positive breast cancer cells ,
LRH-1 promotes cell proliferation by enhancing
ERalpha mediated transcription of target genes such as
GREB-1 . -
pubmed
Collectively these findings indicate the importance of
LRH-1 in the progression of hormone - dependent
breast cancer and implicate
LRH-1 as a potential avenue for drug development . -
pubmed
The elevated level of
alkaline phosphatase ,
hypophosphatemia and inappropriate
phosphaturia suggested the diagnosis of
hypophosphatemic osteomalacia secondary to
proximal renal tubulopathy . -
pubmed
This report highlights the importance of considering the diagnosis of
osteomalacia in
patients treated with
tenofovir and emphasizes the need for monitoring
alkaline phosphatase , blood and urinary
phosphate and
creatinine , especially in
patients with risk factors for
bone disease . -
pubmed
Small GTPase R - Ras regulates integrity and functionality of
tumor blood vessels . -
pubmed
We show that
R - Ras , a
small GTPase of the
Ras family , is essential for the establishment of mature , functional blood vessels in
tumors . -
pubmed
The genetic disruption of
R - Ras severely impaired the maturation processes of
tumor vessels in
mice . -
pubmed
Thus ,
R - Ras promotes normalization of the
tumor vasculature . -
pubmed
These findings identify
R - Ras as a critical regulator of vessel integrity and function during
tumor vascularization . -
pubmed
Increased
VWF antigen levels and decreased
ADAMTS13 activity in
preeclampsia . -
pubmed
This study aimed to assess the
von Willebrand factor (
VWF ) antigen levels and its proteolytic enzyme
ADAMTS13 activity in
preeclampsia . -
pubmed
The plasma
ADAMTS13 activity was significantly reduced in
PE as compared with normal pregnancy and non - pregnant women ( P & lt ; 0.01 for both ) . -
pubmed
In contrast , plasma
VWF antigen and
VWF RCO were significantly elevated in
PE , as compared with normal pregnancy group as well as non - pregnant women ( P & lt ; 0.01 for both ) . -
pubmed
In conclusion , reduction of plasma
ADAMTS13 and elevation in
VWF might have a role in the pathogenesis of
PE . -
pubmed
Group V secretory
phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in
allergic pulmonary inflammation . -
pubmed
We reported that
Pla2g5 - null
mice lacking group V secretory phospholipase A2 (
gV - sPLA2 ) showed reduced eosinophilic
pulmonary inflammation and Th2
cytokine generation when challenged with an extract from
house dust mite Dermatophagoides farinae , compared with wild - type ( WT ) controls . -
pubmed
Adoptive transfer studies suggested that gV -
sPLA2 in dendritic cells was necessary for sensitization of
Pla2g5 - null
mice , but was not sufficient to induce the effector phase of
pulmonary inflammation . -
pubmed
In this study , we demonstrate that gV - sPLA2 is inducibly expressed in
mouse and
human macrophages ( M ) activated by
IL-4 and is required for the acquisition of M effector functions that facilitate the effector phase of
pulmonary inflammation . -
pubmed
We demonstrate that gV - sPLA2 expression in M is sufficient for the development of
pulmonary inflammation , even when
inflammation is induced by intrapulmonary administration of
IL-4 . -
pubmed
farinae - challenged WT donor
mice induce
eosinophilia ,
chemokine production , and recruitment of T cells into the lungs of
Pla2g5 - null recipients previously sensitized by WT
D. - pubmed
Our studies identified a unique function of
gV - sPLA2 in activation of M and in their capacity to recruit T cells to amplify the effector phase of
pulmonary inflammation . -
pubmed
This study was designed to investigate the potential role of induction of
HSP70 using
geranylgeranylacetone (
GGA ) on
testicular damage caused by
CCl4 . -
pubmed
These findings suggest that
GGA - induced activation of
HSP 70 significantly alleviate
CCl4 inflicting
testicular damage by
HSP 70 mediated cytoprotection and antioxidant effects . -
pubmed
In a recent issue of Cell , Leprivier and colleagues demonstrate that
eEF2 K , which can inhibit translation elongation acutely during protein synthesis , is a critical switch in the survival versus death fate of starved
cancer cells . -
pubmed
Human T cell leukemia virus type 1 ( HTLV-1 ) is associated with a
neurological syndrome named
tropical spastic paraparesis /
HTLV - associated myelopathy (
TSP /
HAM ) and the disease progression involves
viral factors . -
pubmed
This study aimed to assess the molecular diversity of
gp21 and
HBZ proteins in
TSP /
HAM and healthy carriers . -
pubmed
[
Interleukin-2 ( Ronkoleykin ) in the first - line chemotherapy for
B - cell non - Hodgkin lymphoma ] . -
pubmed
In this paper we present the results of a randomized prospective study , in which we examined the influence of
rIL-2 ( " Ronkoleykin " ) on the effectiveness of the
R - CHOP combination in the first - line treatment of
patients with
B - cell non - Hodgkin lymphomas . -
pubmed
It was found that the inclusion of
rIL-2 in the
R - CHOP regimen increased the effectiveness of the treatment of
B - cell NHL with a high - risk of poor disease 's course . -
pubmed
Pertussis vaccine antigen - specific
IgG levels , antibody avidities , and
IgG subclasses , as well as T - cell
cytokine levels , were measured by fluorescent bead - based multiplex immunoassays . -
pubmed
The association between the
HLA system and
retinopathy development in patients with
type 1 diabetes mellitus . -
pubmed
The aim of this study was to determine the role of the
HLA system in the development of
DR in patients with
type 1 diabetes mellitus . -
pubmed
The study confirms the influence of
HLA genes in the development of
DR in Croatian
type 1 diabetic patients . -
pubmed
In our patients , susceptibility to
PDR appears to be primarily associated to
DQB1 * 0201 with the relative risk , RR = 5.29 and DQB1 * 0302 ( RR = 2.84 ) . -
pubmed
Anti -
NMDAR encephalitis misdiagnosed as
Hashimoto ' s encephalopathy . -
pubmed
Anti - N - methyl - D - aspartate receptor (
NMDAR )
encephalitis is a well - defined
autoimmune disorder . -
pubmed
We described a 14 - year - old - girl presenting with a clinical picture consistent with the diagnosis of anti -
NMDAR encephalitis , confirmed by
NMDAR antibody testing . -
pubmed
Anti -
NMDAR encephalitis and
HE share similar clinical features so that the differential diagnosis can be difficult if specific antibodies are not tested . -
pubmed
The correct diagnosis of anti -
NMDAR encephalitis is crucial to plan the appropriate management and follow - up , namely in term of oncological screening , since it can be paraneoplastic in origin . -
pubmed
We suggest to re - evaluate the clinical history of all subjects with previous
HE diagnosis in order to evaluate the possible diagnosis of anti -
NMDAR encephalitis and plan the appropriate management of these
patients . -
pubmed
To address this potential limitation , we examined the regional LD pattern of
leucine - rich repeat kinase 2 (
LRRK2 ) gene , which is responsible for both autosomal dominant and
sporadic Parkinson ' s disease (
PD ) , in Caucasians ( CEU ) , Japanese ( JPT ) and Chinese (
CHB ) from HapMap and Chinese ( CHS ) , Malays ( MAS ) and Indians ( INS ) from the Singapore Genome Variation Project ( SGVP ) utilizing the traditional heatmaps and targeted analysis of
LRRK2 gene via Monte Carlo simulation through varLD scores of these ethnic groups . -
pubmed
Our study suggests that there is a higher chance to detect associations between
PD and those trait - associated SNPs of
LRRK2 gene found in Caucasian studies in
INS , while those found in Japanese studies are likely to be better replicated among
CHB . -
pubmed
OBJECTIVE : To study the association between
Epstein Barr ( EB ) virus A73 gene polymorphism and
nasopharyngeal carcinoma (
NPC ) in a Chinese Han population . -
pubmed
On the other hand , only 3 inhibited inflammatory parameters such as
hyperalgesia ,
edema , and local production of
TNF - alpha following induction with complete Freund 's adjuvant . -
pubmed
Brain - derived neurotrophic factor (
BDNF ) Val66Met polymorphism influences the association of the methylome with maternal
anxiety and neonatal brain volumes . -
pubmed
Here we examined the influence of a variant in the brain - derived neurotropic factor (
BDNF ) gene ( Val66Met ) , which underlies synaptic plasticity throughout the central nervous system , on the degree to which antenatal maternal
anxiety associated with neonatal DNA methylation . -
pubmed
Infant , but not maternal ,
BDNF genotype dramatically influences the association of antenatal
anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure . -
pubmed
Thus , antenatal Maternal
Anxiety x
BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus . -
pubmed
Arabidopsis RNA - dependent RNA polymerases and
dicer - like proteins in antiviral defense and small interfering RNA biogenesis during
Turnip mosaic virus infection . -
pubmed
We report a case of multiple lung metastases of an
epithelioid sarcoma originating in the inguinal area that we treated with the
multikinase inhibitor
pazopanib . -
pubmed
Forkhead box M1 (
FoxM1 ) , a transcription factor of the Forkhead family , is demonstrated to be critical for proliferation , apoptosis , migration and invasion of
lung cancer . -
pubmed
Successful treatment of
FKBP51 - expressed
multicentric reticulohistiocytosis using combination therapy with low - dose denosumab and
tacrolimus . -
pubmed
Bone Marrow Mononuclear Cell Transplantation Restores Inflammatory Balance of
Cytokines after
ST Segment Elevation Myocardial Infarction . -
pubmed
Here , we studied in detail the acute effect of bone marrow mononuclear cell ( BMMNC ) transplantation on proinflammatory and anti - inflammatory
cytokines in
patients with
ST segment elevation myocardial infarction (
STEMI ) . -
pubmed
CONCLUSIONS : BMMNC transplantation is associated with preserved balance between pro- and anti - inflammatory
cytokines after
STEMI in PCI - treated
patients . -
pubmed
A Novel Nonsense Mutation in
DNAJC6 Expands the Phenotype of
Autosomal - Recessive Juvenile - Onset Parkinson ' s Disease . -
pubmed
Bronchial lavage
P 16INK4A gene promoter methylation and
lung cancer diagnosis : A meta - analysis . -
pubmed
OBJECTIVE : To evaluate the diagnostic value of bronchial lavage
P16INK4A promoter methylation and
lung cancer . -
pubmed
MATERIALS AND METHODS : The databases of PubMed , Medline , China National Knowledge Infrastructure , and Wanfang were electronically searched by two reviewers to find the suitable studies related to the association between
P16INK4A promoter methylation and
lung cancer . -
pubmed
The diagnostic sensitivity , specificity , and area under the receiver operating characteristic ROC curve of bronchial lavage
P16INK4Aas a biomarker for diagnosis of
lung cancer were pooled by stata 11.0 software ( Stata Corporation , College Station , TX , USA ) . -
pubmed
The pooled sensitivity and specificity of bronchial lavage
P16INK4A promoter methylation for
lung cancer diagnosis were 0.61 ( 95 % confidence interval [ CI ] : 0.57 - 0.65 ) and 0.81 ( 95 % CI : 0.78 - 0.85 ) , respectively , with random effect model . -
pubmed
The systematic area under the ROC was 0.72 ( 95 % CI : 0.68 - 0.76 ) , which indicated that the diagnostic value of bronchial lavage
P16INK4A promoter methylation for
lung cancer was relatively high . -
pubmed
CONCLUSION : Bronchial lavage
P16INK4A promoter methylation can be a potential biomarker for diagnosis of
lung cancer . -
pubmed
This study evaluates the nuclear and mitochondrial DNA integrity of
prostate carcinoma cells ,
CAS , matched benign epithelium and benign epithelium - associated stroma by whole - genome copy - number analyses , targeted sequencing of
TP53 , and FISH . -
pubmed
No somatic
TP53 mutations were observed in
CAS . -
pubmed
Despite the relatively modest
ColR - dependent changes of wild - type ,
colR deficiency resulted in drastic proteome alterations , with 122 proteins up- and 62 down - regulated by
zinc . -
pubmed
HSV-2 infection resulted in the activation of
PI3 K and
Akt in the host cells , and
BX-795 treatment inhibited HSV-2 - induced
Akt phosphorylation and activation . -
pubmed
HSV-2 infection increased the phosphorylation of
JNK and
p38 , and reduced
ERK phosphorylation at 8 h postinfection in the host cells ;
BX-795 treatment inhibited HSV-2 - induced activation of
JNK and
p38 MAP kinase as well as the phosphorylation of
c - Jun and
ATF-2 , the downstream targets of
JNK and
p38 MAP kinase . -
pubmed
RESULTS : 21.4 % of
patients received no treatment , 20.8 % received ipilimumab and 57.5 % of patients with
BRAF - positive
tumors received
vemurafenib /
dabrafenib . -
pubmed
Primary
rat TM epithelial cell cultures positive for
pancytokeratin had colony forming activity and could be enriched for
CK 19 - positive cells that were capable of culture expansion by proliferation and cell migration when subject to a
wound assay . -
pubmed
Methods : Biomarkers of endothelial activation and injury , immune functions , platelet activation and
insulin resistance were measured in 8 - week old male C57BL/6
mice exposed to commercial snuff , CRP-2 reference snuff , commercial snus ,
CRP-1 reference snus , and
nicotine in drinking water ( 100 microg / mL ) for 4 , 12 , and 24 weeks . -
pubmed
Increased formation of proinflammatory
cytokines such as
TNFalpha by
nicotine or Copenhagen snuff may lead to
vascular inflammation and thereby exacerbate atherogenesis . -
pubmed
In the late 1980s , when
GLUT4 , the major
insulin - regulated
glucose transporter , was identified , my lab observed that it was downregulated in adipocytes but not in skeletal muscle in
insulin - resistant states , such as
obesity and
type 2 diabetes , in
humans and
rodents . -
pubmed
AMPK activation protects against diet induced
obesity through
Ucp1 - independent thermogenesis in subcutaneous white adipose tissue . -
pubmed
Conclusion : Fecal transplantation can alleviate lipopolysaccharide - induced
acute lung injury in
rats , and its regulatory effect may be related to inhibiting the activation of
PI3K /
AKT /
NF - kappaB signaling pathway and reducing the expression of
inflammatory factor ICAM-1 . -
pubmed
Azoramide improves
mitochondrial dysfunction in
palmitate - induced
insulin resistant
H9c2 cells . -
pubmed
Although the effect of
azoramide in
glucose - homeostasis in
mammalians is not known very well , a limited number of experimental studies showed that it could improve the
insulin sensitivity in genetically
obese mice . -
pubmed
Durable Response of Low - Dose
Afatinib plus Cetuximab in an
Adenocarcinoma Patient with a Novel
EGFR Exon 20 Insertion Mutation . -
pubmed
Orientin suppresses oxidized
low - density lipoproteins induced
inflammation and oxidative stress of macrophages in
atherosclerosis . -
pubmed
RAW 264.7 were treated with 80 mug / mL oxidized
low - density lipoproteins ( ox - LDL ) to mimic
atherosclerosis in vitro . -
pubmed
Orientin inhibited ox - LDL - induced
inflammation and oxidative stress , and
CD36 may be the key regulator during
Orientin action . -
pubmed
Despite its physiologic importance in maintaining angiogenic balance , excess
sFlt-1 levels are associated with the pathogenesis of many diseases , especially those with angiogenic imbalance ,
endothelial dysfunction , and
hypertension . -
pubmed
Sarcopenia and
COVID-19 : A Manifold Insight on
Hypertension and the
Renin Angiotensin System . -
pubmed
Safety and Clinical Activity of
MEDI0562 , a Humanized
OX40 Agonist Monoclonal Antibody , in Adult
Patients With Advanced Solid
Tumors . -
pubmed
A meta - analysis of the prognostic significance of
Golgi protein 73 in
hepatocellular carcinoma in Chinese
patients . -
pubmed
Introduction : In recent years , an increasing number of studies have revealed the possible prognostic significance of
Golgi protein 73 (
GP73 ) in
hepatocellular carcinoma (
HCC ) , but the results are still controversial . -
pubmed
Therefore , we performed a meta - analysis to explore the possible correlation between
GP73 and prognostic value in
HCC . -
pubmed
The results indicated that
GP73 overexpression was significantly associated with later
tumour stage , higher
tumour grade and poor overall survival ( OS ) . -
pubmed
Combined analysis of three studies showed no statistical correlation between high
GP73 expression and
disease - free survival ( DFS ) . -
pubmed
Conclusions : The meta - analysis suggested that overexpression of
GP73 may be associated with poor prognosis in
HCC and may also have a predictive role for
HCC invasion and metastasis . -
pubmed
Recent Discoveries in the
Androgen Receptor Pathway in Castration - Resistant
Prostate Cancer . -
pubmed
The
androgen receptor (
AR ) is the main therapeutic target in advanced
prostate cancer , because it regulates the growth and progression of
prostate cancer cells . -
pubmed
The circulating miR-146a level was significantly lower in
patients with
CML than in healthy
subjects and showed a significant rise after 14 days of
imatinib treatment and an inverse correlation with
BCR -
ABL expression levels at 90 days . -
pubmed
Stapled Peptides Based on
Human Angiotensin - Converting Enzyme 2 (
ACE2 ) Potently Inhibit
SARS - CoV-2 Infection In Vitro . -
pubmed
SARS - CoV-2 uses
human angiotensin - converting enzyme 2 (
ACE2 ) as the primary receptor to enter host cells and initiate the
infection . -
pubmed
Here , we report the design of four stapled peptides based on the
ACE2 helix , which is expected to bind to
SARS - CoV-2 and prevent the binding of the virus to the
ACE2 receptor and disrupt the
infection . -
pubmed
The aims of this study were ( i ) to determine whether different metabolic profiles of
B - vitamins and
vitamin A in Brazilian children and adolescents were positively or negatively related to
homocysteine and
omega-3 fatty acids using k - means clustering analysis , ( ii ) compare nutrient intakes and metabolites between the different metabolic profiles , ( iii ) evaluate if the statistically significant metabolites found between the metabolic groups , can predict the variation of
leukotriene A4 hydrolase (
LTA4H ) levels , a biomarker of
low - grade inflammation , in the total studied population . -
pubmed
Integrin beta1 plays an essential role in the crosstalk between
tumor cells and their microenvironment . -
pubmed
Women with
21OHD have reduced fertility because of excessive production of adrenal
androgen and
progesterone , which can inhibit folliculogenesis , disturb the normal
gonadotropin secretion pattern and development of the endometrium , and affect endometrial receptivity . -
pubmed
They do not stimulate the production of antibodies at all or only very slightly , reduce
insulin resistance and
allergic reactions , cause
lipodystrophies to disappear and lower the
insulin requirement . -
pubmed
Whether these
insulins can also reduce
vascular complications can not yet be finally decided . -
pubmed
S-100 staining for the diagnosis of
melanoma of the anal canal . -
pubmed
Structural and expression analyses of normal and mutant mRNA encoding
glycine decarboxylase : three - base deletion in mRNA causes
nonketotic hyperglycinemia . -
pubmed
We studied the structure of the mutant
P - protein mRNA expressed in the liver of a
patient with
nonketotic hyperglycinemia (
NKH ) deficient of
P - protein . -
pubmed
Functional and phenotypic characteristics of effusion - associated lymphoid cells cultured in the presence of either recombinant
interleukin 2 or
T - cell growth factor from
malignant pleural and peritoneal effusions in
patients with advanced
carcinoma . -
pubmed
Malignant pleural or peritoneal effusion - associated lymphoid ( EAL ) cells from 17
patients with advanced
carcinoma were cultured with autologous carcinoma cells in the presence of either recombinant
interleukin 2 (
rIL 2 ) or
T - cell growth factor (
TCGF ) . -
pubmed
In facts , viable
carcinoma cells co - cultured with EAL cells and
TCGF mostly disappeared during 14 days . -
pubmed
The majority of killer - effector cells against allogeneic cells in
rIL 2 - activated EAL cells from
cancer patients showed
CD4+Leu8- phenotype at population level . -
pubmed
In order to establish the possible existence of a cardiac converting enzyme and its role in the pathophysiology of the
myocardial ischemia , the direct cardiac effects of IEC and
AI or
AII were studied on the isolated
rat heart perfused through the left atria . -
pubmed
Double esterase (
DE ) positivity in
AML cells . -
pubmed
Differential reactivity of rheumatoid synovial cells and serum
rheumatoid factors to
human immunoglobulin G subclasses 1 and 3 and their
CH3 domains in
rheumatoid arthritis . -
pubmed
19S IgM rheumatoid factors (
RF ) are polyclonal autoantibodies that may play an important pathogenic role in sustaining inflammatory
synovitis in
rheumatoid arthritis (
RA ) . -
pubmed
RF in
RA have reactivity for as - yet - uncharacterized antigenic determinants in
IgG Fc . -
pubmed
In 10
patients with cat
asthma and
hay fever , we quantified the doses of cat allergen ( expressed as cat allergen 1 [
Cat-1 ] in log Food and Drug Administration [ FDA ] units ) inspired from the ambient air of a room containing living
cats required to induce a 20 % drop in FEV1 . -
pubmed
Defects of
thrombin - induced protein phosphorylation in platelets from
stroke - prone spontaneously
hypertensive rats . -
pubmed
[
Cholinesterase activity in the humor of the anterior chamber and in the blood in
patients with
glaucoma and
cataract ] . -
pubmed
[ Value of serum
ornithine carbamoyltransferase activity in the diagnosis
liver diseases ] . -
pubmed
Increased
thyrotrophin and
prolactin secretion induced by
domperidone in
hypothyroid subjects . -
pubmed
The
thyrotrophin (
TSH ) and
prolactin (
Prl ) releasing effects of
domperidone , a recently developed antidopaminergic drug which does not cross the blood - brain barrier , were investigated in 8
women affected by
primary hypothyroidism , and were compared to those elicited by another antidopaminergic drug ,
sulpiride . -
pubmed
In
streptozotocin induced
diabetic rats , the
amylase content and
amylase release from isolated pancreatic acini stimulated by
CCK-8 were significantly decreased . -
pubmed
Both decrease could be reversed when
vanadate , a chemical which is capable of lowering blood
glucose without effect on serum
insulin level in
diabetic rats , was given intragastrically . -
pubmed
Clomipramine - induced
agranulocytosis and its treatment with
G - CSF . -
pubmed
Moreover , binding of
gC to two
heparan sulfate - deficient L - cell lines ,
gro2C and sog9 , both of which are mostly resistant to
HSV infection , was markedly reduced . -
pubmed
Hematopoietic growth factors for the treatment of severe
chronic neutropenia . -
pubmed
,
congenital neutropenia (
Kostmann ' s syndrome and related syndromes ) ,
idiopathic neutropenia ( both childhood and adult ) , and
cyclic neutropenia , it is now established that long - term treatment with the
hematopoietic growth factor , recombinant
human granulocyte colony stimulating factor (
rHuG - CSF or Filgrastim ) , can elevate blood neutrophil counts to the normal range in most
patients , with a concomitant reduction in
infection - related events including
fever ,
oral ulcerations , antibiotic use and symptoms of
inflammation . -
pubmed
Before the discovery of the
BRCA1 and
BRCA2 genes , if a first - degree relative in direct genetic lineage had
hereditary breast cancer or
hereditary breast - ovarian cancer syndrome , the best estimate of family members ' genetic risk for
breast cancer was 50 % . -
pubmed
Now the lifetime
cancer destiny of a patient who carries a
BRCA1 or
BRCA2 germ line mutation can be determined with an extraordinary degree of precision . -
pubmed
In this study we have used
ARL 66096 , a potent antagonist of
ADP - induced
platelet aggregation , and a
P2X ionotropic receptor agonist ,
alpha , beta - methylene adenosine 5 '- triphosphate , to distinguish the
ADP - induced intracellular events . -
pubmed
Furthermore , the decline of
MnSOD mRNA and
MnSOD activity levels coincides with increasing
cytotoxicity . -
pubmed
Role of
transforming growth factor - beta pathway in the mechanism of
wound healing by
saponin from
Ginseng Radix rubra . -
pubmed
The effects of
saponin from
Ginseng Radix rubra on extracellular matrix metabolism , the activation and synthesis of
TGF - beta1 , and the modification of
TGF - beta receptor in fibroblasts were examined to elucidate the contribution of the
TGF - beta pathway to the mechanism of
wound healing by
saponin . -
pubmed
Recently , we have shown that
hyperinsulinemia increases the activity of
farnesyltransferase (
FTase ) in vitro ( 1 ) and in hyperinsulinemic
animals ( 2 ) , stimulates the phosphorylation of the
FTase alpha - subunit ( 3 ) , increases the amounts of cellular farnesylated
p21Ras ( 4 ) , and potentiates the nuclear effects of other peptide growth factors , such as
EGF ,
IGF-1 and
PDGF ( 5 ) . -
pubmed
Analysis of
Chlamydomonas reinhardtii sta11 - 1 mutants revealed a correlation between a
D - enzyme deficiency and specific alterations in amylopectin structure and starch biosynthesis , thereby suggesting previously unknown biosynthetic functions . -
pubmed
A mutation in the 5 ' non - high mobility group box region of the
SRY gene in patients with
Turner syndrome and Y mosaicism . -
pubmed
Mutations of
SRY ( testis - determining gene ) constitute the cause of XY sex reversal in approximately 10 - 15 % of females with pure
gonadal dysgenesis . -
pubmed
We carried out molecular studies of the
SRY gene in three patients with a
UTS phenotype and
bilateral streaks ; two presented a 45,X/46,XY mosaic , and the third a Y marker chromosome . -
pubmed
A previous report of a 46,XY patient with
partial gonadal dysgenesis who presented the same mutation as our patients indicates the probable existence of a hot spot in this region of the
SRY gene and strengthens the possibility that all
gonadal dysgeneses constitute part of a spectrum of the same disorder . -
pubmed
In the RVM of decerebrate
piglets 2 - 15 days of age , we studied the effects of electrolytic lesions ( n=7 ) or microdialysis of
muscimol ( n=15 ) , a
GABAA receptor agonist , on ventilatory output and the response to
hypercapnia . -
pubmed
Substance P induced
histamine release from nasal mucosa of
subjects with and without
allergic rhinitis . -
pubmed
CONCLUSION : These findings suggest a role of
SP in inducing release of
histamine from
human nasal mucosa , thereby influencing physiologic and pathophysiologic nasal conditions , especially in
allergic inflammatory processes . -
pubmed
The deregulated
tyrosine kinase activity of the
BCR -
ABL fusion protein is the cause of malignant transformation in almost all cases of
chronic myelogenous leukaemia (
CML ) , making
BCR -
ABL an ideal target for pharmacological inhibition . -
pubmed
Studies by immunoblotting using membrane fractions from peripheral blood or spleen from normal
mice where
reticulocytosis was induced by
erythropoietin (
EPO ) or
phenylhydrazine (
PHZ ) treatment suggest that
DMT1 is coexpressed with
transferrin receptor (
TfR ) in erythroid cells . -
pubmed
The metastasis gene
osteopontin : a candidate target for
cancer therapy . -
pubmed
The
cytokine osteopontin is essential for the dissemination of various
cancers . -
pubmed
Past research has implied several modes in which
osteopontin and its main receptors on
tumor cells can be suppressed . -
pubmed
The receptor
integrin alpha ( V ) beta ( 3 ) contributes not only to
tumor cell dissemination , but also to angiogenesis and
osteolysis in
bone metastases . -
pubmed
Myocardial ischemic injury after heart transplantation is associated with upregulation of
vitronectin receptor (
alpha ( v ) beta3 ) , activation of the
matrix metalloproteinase induction system , and subsequent development of
coronary vasculopathy . -
pubmed
Matrix metalloproteinases (
MMPs ) are activated in
ischemic injury models . -
pubmed
At 1 year ,
MMPs were evaluated , and interstitial
myocardial fibrosis was quantified . -
pubmed
Compared with control , the
ischemia group demonstrated evidence of significant increased expression of
alpha ( v ) beta3 ( 3.2 - fold , P<0.001 ) ,
tissue factor ( 2.5 - fold , P<0.001 ) , and
EMMPRIN ( 1.9 - fold , P=0.01 ) . -
pubmed
At 1 year , the
ischemia group had a significant increase in
myocardial fibrosis ( 24+/-1.8 % versus 14+/-1.1 % , P<0.001 ) and zymographic activity of
MMP-2 ( 1.4 - fold , P<0.001 ) ,
MMP-3 ( 1.2 - fold , P<0.001 ) , and
MMP-9 ( 1.3 - fold , P=0.01 ) . -
pubmed
CONCLUSIONS :
Myocardial ischemic injury after cardiac transplantation is associated with upregulation of
alpha ( v ) beta3 ,
tissue factor , and activation of the
MMP induction system , which may contribute to the subsequent development of allograft remodeling and
vasculopathy . -
pubmed
RESULTS : By using 2 - dimensional proteomics , a protein fraction at 40 kd was recognized by serum
IgE from 86 % ( 12/14 ) of the
patients with
hazelnut allergy with systemic reactions . -
pubmed
BAX and
BAK are essential regulators of proapoptotic signaling , and the disruption of apoptosis is linked to the development of
cancer . -
pubmed
In contrast ,
E1A- and
p53DD - transformed
BAX- and
BAK - deficient BMKs formed highly invasive
carcinomas . -
pubmed
Transformed BMKs deficient for either
BAX or
BAK were also tumorigenic , but only when heterozygous for the remaining
bax or
bak allele , the expression of which was lost in most resulting
tumors . -
pubmed
Several members of the FGF family , in particular
FGF2 , are intimately involved in neuronal protection and repair after ischemic , metabolic or
traumatic brain injury . -
pubmed
Expression of
Fgf2 mRNA and protein is strongly upregulated after
neuronal damage , with glial cells as the predominant source . -
pubmed
Given its survival - promoting effects on cultured neurons , exogenous
FGF2 was tested in several
animal models of
stroke and
excitotoxic damage , in which it consistently proved protective against
neuronal loss . -
pubmed
Despite the well - documented benefits of
FGF2 in
animal models of
stroke , there is currently no clinical development in
stroke , after a phase II / III trial with
FGF2 in
acute stroke patients was discontinued because of an unfavorable risk - to - benefit ratio . -
pubmed
Cytochrome P450 ( CYP ) 1A1 has long been known to be one of the metabolic enzymes involved in activating many procarcinogens , the first step toward
tumor formation during chemical carcinogenesis . -
pubmed
Apart from recent findings of constitutive activation of some
transcription factors and autocrine stimulation by
cytokine receptors , the mechanisms of malignant transformation in
cHL still remain poorly understood . -
pubmed
Several of the differentially expressed genes may play a role in the pathogenesis of
cHL because they represent potential oncogenes , such as
rhoC ,
L - myc , and
PTP4A , or
transcription factors , such as
ATF-5 ,
ATBF1 , and
p21SNFT . -
pubmed
[
Serum lipoproteins in
hypertonic disease ] . -
pubmed
Depression by
relaxin of neurally induced contractile responses in the
mouse gastric fundus . -
pubmed
In vivo magnetic resonance imaging of
coronary thrombosis using a
fibrin - binding molecular magnetic resonance contrast agent . -
pubmed
BACKGROUND : The advent of
fibrin - binding molecular magnetic resonance ( MR ) contrast agents and advances in coronary MRI techniques offers the potential for direct imaging of
coronary thrombosis . -
pubmed
We tested the feasibility of this approach using a
gadolinium (
Gd)-based
fibrin - binding contrast agent , EP-2104R ( EPIX Medical Inc ) , in a
swine model of
coronary thrombus and in - stent
thrombosis . -
pubmed
METHODS AND RESULTS : Ex vivo and in vivo sensitivity of coronary MR thrombus imaging was tested by use of intracoronarily delivered
Gd - DTPA - labeled
fibrinogen thrombi ( n=6 ) . -
pubmed
Fibrinogen thrombi : 5 of 6 intracoronarily delivered
Gd - labeled
fibrinogen clots ( approximately 250 micromol / L Gd ) were visible on MRI and subsequently confirmed by x - ray angiography . -
pubmed
CONCLUSIONS : We demonstrate the feasibility of MRI of
coronary thrombus and in - stent
thrombosis using a novel
fibrin - binding molecular MR contrast agent . -
pubmed
There was high agreement between
Hb in capillary blood by the HemoCue and in venous blood by the counter ( r icc=0.86 ; p<0.01 ) , and also between the diagnosis of
anemia by both equipments ( k=0.81 ; p<0.01 ) . -
pubmed
The presence of
CD5 ,
CD10 , and
Bcl-1 co - expression by immunohistochemistry and detectable t(11;14 ) and
cMYC gene rearrangement by FISH analyses in the Burkitt region support a transformation of
mantle cell lymphoma over a concomitant malignancy . -
pubmed
A limited number of
mantle cell lymphomas demonstrating dual t(11;14 ) and chromosome 8q24
cMYC gene rearrangements have been previously reported in the literature . -
pubmed
CASE REPORT : Child with left
middle cerebral artery territory infarction in which several thromboembolic risk factors were documented both in the child (
neonatal sepsis and factor V Leiden ) and his mother (
lupus anticoagulant , pre - eclampsy and
factor V Leiden ) . -
pubmed
The
endothelin system and its role in
pulmonary arterial hypertension (
PAH ) . -
pubmed
The diagnosis was confirmed by liver biopsy proven decreased
AGT activity in 68 % of cases ,
hyperoxaluria in 74 % ,
hyperglycolicaciduria in 37 % and
hyperoxalaemia in 50 % . -
pubmed
In the present study , we show that subtoxic concentrations of
curcumin sensitize
human renal cancer cells to the
tumor necrosis factor - related apoptosis inducing ligand (
TRAIL)-mediated apoptosis . -
pubmed
A common dermatological finding in many
SLE - prone
mouse strains is the deposition of
immunoglobulins at the dermoepidermal junction . -
pubmed
Over the past decade , the most exciting and important finding has been the discovery of the
Fas - defect in the pathogenesis of the autoimmune MRL / lpr
mouse , which is a good model for the spontaneous development of
skin lesions similar to those seen in
human LE . -
pubmed
The analysis of
MRL / lpr mice showed a close association between
immunoglobulin deposits and the appearance of
skin lesions . -
pubmed
Cutaneous LE lesions can also be induced in
TCRalpha-/-
mice treated with
fluorouracil and ultraviolet B light irradiation . -
pubmed
Plasma
cytokine concentrations were significantly larger in the
endotoxemia group than in the other groups . -
pubmed
IMPLICATIONS :
Sevoflurane pretreatment decreased mortality rate , severity of
hypotension , and
acidosis , and inhibited
cytokine responses in
rats injected with endotoxin , suggesting that
sevoflurane may be an anesthetic of choice in
endotoxemic states . -
pubmed
Some patients show normal
ALT levels , whereas others develop severe
hepatitis exacerbations (
SHEs ) due to YMDD mutants . -
pubmed
Patients with
SHE had more substitutions in the
reverse transcriptase (
rt ) region within the polymerase gene at the time of exacerbation than those without
SHE , although no specific substitutions were noted . -
pubmed
The mechanism of latex
allergy and the immune responses following reexposure of latex allergens by the intranasal route was studied in a
murine model of
latex allergy developed by intragastric sensitization with
NRL . -
pubmed
Biliary excretion was investigated in
mdr1a / b - knockout
mice ,
Bcrp - knockout
mice and
Mrp2 - defective Eisai
hyperbilirubinemic rats ( EHBRs ) . -
pubmed
Irreversible cytoskeletal disarrangement is independent of
caspase activation during in vitro
azaspiracid toxicity in
human neuroblastoma cells . -
pubmed
Besides damage to several tissues in vivo ,
AZA-1 has been shown to cause
cytotoxicity in a number of cell lines and alterations in
actin cytoskeleton and cell morphology . -
pubmed
The
JNK inhibitor
SP600125 seemed to slightly diminish
AZA-1 effects , however due to the effects of the drug by itself the involvement of
JNK in
AZA-1 toxicity needs further investigation . -
pubmed
Cytotoxicity of
AZA-1 has been previously described without reference to the type of cell death , we report that
AZA-1 induces the activation of
caspases , commonly used as an early marker of apoptosis , and that these
proteases are not responsible for
AZA-1 - induced cytoskeleton disarragement in
human neuroblastoma cells . -
pubmed
Five important forms of
nonallergic angioedema can be distinguished : hereditary (
HAE ) , acquired (
AAE ) ,
renin -
angiotensin -
aldosterone system ( RAAS)-blocker - induced (
RAE ) ,
pseudoallergic angioedema (
PAE ) and
idiopathic angioedema (
IAE ) . -
pubmed
Today , a plasma pool
C1 - esterase inhibitor ( C1 - INH ) concentrate is the therapy of choice in
HAE . -
pubmed
According to currently available reports , these drugs may improve the treatment of
kinin - induced
angioedema . -
pubmed
SIRT1 activation confers neuroprotection in experimental
optic neuritis . -
pubmed
The authors examined potential neuroprotective effects in
optic neuritis by
SRT647 and
SRT501 , two structurally and mechanistically distinct activators of
SIRT1 , an enzyme involved in cellular stress resistance and survival . -
pubmed
Treatment with either
SIRT1 activator did not prevent
EAE or
optic nerve inflammation . -
pubmed
CONCLUSIONS :
SIRT1 activators provide an important potential therapy to prevent the
neuronal damage that leads to permanent
neurologic disability in
optic neuritis and
MS patients . -
pubmed
Intravitreal administration of
SIRT1 activators does not suppress
inflammation in this model , suggesting that their neuroprotective effects will be additive or synergistic with current immunomodulatory therapies . -
pubmed
Intravenous
immunoglobulin therapy of
lupus pneumonitis . -
pubmed
The role of intravenous
immunoglobulin during acute life threatening pulmonary emergencies in a case of
SLE prompted this clinical brief . -
pubmed
Huntington ' s disease is caused by an abnormal CAG expansion within the gene encoding
Huntingtin which induces a major
cortico - striatal degeneration as well as motor and
cognitive impairments . -
pubmed
Polymorphisms in the promoter region of the
basic fibroblast growth factor gene and proliferative
diabetic retinopathy in
Caucasians with
type 2 diabetes . -
pubmed
BACKGROUND :
Basic fibroblast growth factor (
bFGF ) expression is implicated in proliferative
diabetic retinopathy (
PDR ) . -
pubmed
The aim of this study was to investigate the association of genetic polymorphisms ( -553T / A , -834T / A and -921C / G ) in the promoter region of the
bFGF gene with PDR in
patients with
type 2 diabetes . -
pubmed
We analysed serum
bFGF levels in 78
subjects with
type 2 diabetes and 25
subjects without
diabetes . -
pubmed
Significantly higher
bFGF serum levels were demonstrated in
diabetics with the AT genotype of the -553 polymorphism compared with diabetics with the TT genotype , whereas the -834 and -921 polymorphisms failed to affect serum
bFGF levels . -
pubmed
Response to
prednisone in relation to
NR3C1 intron B polymorphisms in childhood
nephrotic syndrome . -
pubmed
We genotyped 118
children diagnosed with
NS who initially responded to oral GC treatment [
steroid - responsive
nephrotic syndrome (
SRNS ) group ] and 136 healthy children for three intron B single nucleotide polymorphisms of
NR3C1 , namely
Bcl I ( C / G ) , rs33389 ( C / T ) and rs33388 ( A / T ) . -
pubmed
In the
SRNS group , we performed a three - marker haplotype analysis of
NR3C1 in relation to the response to
prednisone , represented as time to
proteinuria resolution ( TPR ) as categorical and ordinal variable . -
pubmed
High nuclear
Livin expression is a favourable prognostic indicator in
renal cell carcinoma . -
pubmed
OBJECTIVES : To assess the protein expression of
Livin , an apoptosis inhibitor , in
renal cell carcinoma (
RCC ) and to determine its prognostic relevance . -
pubmed
PATIENTS AND METHODS : Immunohistochemical staining for
Livin was performed in tissue microarrays ( TMAs ) , including
tumour tissue cores , from
patients with
RCC who had undergone renal surgery . -
pubmed
In 682 TMAs cytoplasmatic staining intensity and nuclear staining quantity were evaluated , and the association of
Livin expression with progression - free survival ( PFS ) and
cancer - specific survival ( CSS ) was analysed with a multivariate Cox regression model . -
pubmed
In multivariate analysis , high ( & gt;25 % ) nuclear
Livin expression was a favourable independent predictor of PFS and CSS even after adjusting for
tumour stage , Fuhrman grade , age , sex and Karnofsky severity rating . -
pubmed
CONCLUSION : High nuclear
Livin expression is a favourable independent predictor of PFS and CSS in
patients with
RCC . -
pubmed
CONCLUSIONS :
BRCA mutation carriers were more likely to believe PM to be the best way to reduce both risk and worry of
breast cancer . -
pubmed
METHODS : Two hundred twenty - six men from families with a known
BRCA1 or
BRCA2 mutation were recruited through an epidemiological database of high - risk
breast cancer families and completed a self - administered questionnaire . -
pubmed
Hence , some of the assumptions about what makes information on
BRCA1 or
BRCA2 status salient to men and may therefore influence their attendance at a
cancer genetic clinic are not borne out in this study . -
pubmed
ebr3 has an elevated expression of
PBZ1 and
PR1 only in tissue displaying the
LM phenotype . -
pubmed
ncr1 strongly expresses
PBZ1 in tissue displaying the
LM phenotype , whereas
PR1 expression in this tissue is similar to wild - type CO39 . -
pubmed
Day 3 thymectomy ( D3Tx ) results in a loss of peripheral tolerance mediated by natural regulatory T cells ( nTregs ) and development of
autoimmune ovarian dysgenesis (
AOD ) and
autoimmune dacryoadenitis (
ADA ) in A / J and ( C57BL/6J
x A / J ) F(1 ) hybrids ( B6A ) , but not in C57BL/6J ( B6 ) mice . -
pubmed
Visualizing the role of
Cbl - b in control of islet - reactive CD4 T cells and susceptibility to
type 1 diabetes . -
pubmed
The
E3 ubiquitin ligase Cbl - b regulates T cell activation thresholds and has been associated with protecting against
type 1 diabetes , but its in vivo role in the process of self - tolerance has not been examined at the level of potentially autoaggressive CD4(+ ) T cells . -
pubmed
Cblb deficiency subsequently precipitated
diabetes in most
TCR : insHEL
animals by 15 wk of age . -
pubmed
Reduction of plasma
gelsolin levels correlates with development of
multiple organ dysfunction syndrome and fatal outcome in
burn patients . -
pubmed
We hypothesized that the extent of
pGSN reduction might correlate with different outcome of
burn patients . -
pubmed
The study was performed to evaluate the prognostic implications of
pGSN levels on the development of
multiple organ dysfunction syndrome (
MODS ) and fatal outcome in a group of severely
burn patients . -
pubmed
The results showed that
pGSN concentrations , as well as the levels of
IL-2 and
IFN - gamma , decreased markedly on PBD 1 - 21 , whereas , the levels of
IL-4 increased markedly in all
burn groups as compared with normal controls ( P<0.05 or P<0.01 ) , and there were obviously differences between group I and group III ( P<0.05 or P<0.01 ) . -
pubmed
Moreover , as the
pGSN levels decreased , the incidence of septic complication as well as
MODS remarkably increased . -
pubmed
CONCLUSIONS :
pGSN levels appear to be an early prognostic marker in
patients suffering from
major burns . -
pubmed
[ Diagnostic significance of Th1 / Th2
cytokine pattern in childhood
hemophagocytic lymphohistiocytosis ] . -
pubmed
OBJECTIVE : To illustrate the diagnostic value of Th1 / Th2
cytokine pattern in childhood
hemophagocytic lymphohistiocytosis (
HLH ) and its diagnostic accuracy . -
pubmed
METHOD : The BD(TM ) CBA
Human Th1 / Th2
Cytokine Kit II was used to measure the serum Th1 and Th2
cytokines , including
Interferon - gamma (
IFN - gamma ) ,
tumor necrosis factor (
TNF ) ,
interleukin ( IL )- 10 ,
IL-6 ,
IL-4 and
IL-2 in 50
patients with de novo
HLH admitted to our hospital from Oct. 2005 to Aug. 2009 . -
pubmed
The above
cytokine levels were also determined in 250 healthy
volunteers and 235
patients with
sepsis as controls . -
pubmed
The
IFN - gamma ,
TNF ,
IL-10 ,
IL-6 ,
IL-4 and
IL-2 levels for healthy
children were ( 4.6 + - 1.8 ) ng / L , ( 4.0 + - 1.2 ) ng / L , ( 6.5 + - 1.3 ) ng / L , ( 6.0 + - 1.5 ) ng / L , ( 2.9 + - 0.8 ) ng / L and ( 2.6 + - 0.7 ) ng / L , while the median levels of them in acute phase of
HLH children were 1138.5 ( 49.2 - 5000.0 ) ng / L , 3.4 ( 1.0 - 25.1 ) ng / L , 740.5 ( 26.5 - 5000.0 ) ng / L , 66.1 ( 3.9 - 4472.6 ) ng / L , 3.9 ( 1.0 - 32.8 ) ng / L and 4.0 ( 1.0 - 51.1 ) ng / L , respectively . -
pubmed
IL-4 ,
IL-2 and
TNF slightly elevated or at normal range in acute phase of
HLH . -
pubmed
The
patients with
sepsis showed a different
cytokine pattern , with an extremely high level of
IL-6 ( median : 251.3 ng / L , range : 8.4- & gt ; 5000.0 ng / L ) and moderately elevated level of
IL-10 ( median : 46.5 ng / L , range : 3.1 - 5000.0 ng / L ) , whereas
IFN - gamma was only slightly elevated ( median : 9.2 ng / L , range : 1.3 - 498.8 ng / L ) . -
pubmed
When the criteria for
HLH set as the following :
IFN - gamma & gt ; 100 ng / L ,
IL-10 & gt ; 60 ng / L and the concentration of
IFN - gamma higher than that of
IL-6 , the specificity reached as high as 98.7 % and the sensitivity was 88.0 % for the diagnosis of
HLH among
patients with
HLH and
sepsis . -
pubmed
CONCLUSION : The significant increase of
IFN - gamma and
IL-10 with slightly increased level of
IL-6 is a sensitive and specific
cytokine pattern for childhood
HLH , which is helpful for its diagnosis and differential diagnosis . -
pubmed
Common variants in the
CD36 gene are associated with oral fat perception , fat preferences , and
obesity in African Americans . -
pubmed
The objective of this study was to determine whether
human genetic variation in 5 common
CD36 polymorphisms is associated with oral fat perception of Italian
salad dressings , self - reported acceptance of high - fat foods and
obesity in African - American adults ( n = 317 ) . -
pubmed
RNA interference - mediated knockdown of
SeP in the liver improved
insulin resistance and
hyperglycemia in
type 2 diabetic mice , suggesting that
SeP is a novel therapeutic target for
type 2 diabetes . -
pubmed
Mutational analysis of
cutaneous squamous cell carcinomas and
verrucal keratosis in
patients taking
BRAF inhibitors . -
pubmed
B - RAF inhibitors ( BRAFi ) have been shown to improve rates of overall and progression - free survival in
patients with stage IV metastatic
melanoma positive for the
BRAF V600E mutation . -
pubmed
We have found upstream mutations in
RAS as well as
PIK3CA in both
verrucal keratosis and
cuSCC . -
pubmed
Physical activity and risk of
breast cancer overall and by
hormone receptor status : the European prospective investigation into
cancer and nutrition . -
pubmed
However , whether this holds true for
breast cancer subtypes defined by the
estrogen receptor (
ER ) and the
progesterone receptor (
PR ) status is controversial . -
pubmed
Analyses by hormone receptor status suggested differential associations for total physical activity ( p - heterogeneity = 0.04 ) , with a somewhat stronger inverse relationship for
ER+/
PR+ breast
tumors , primarily driven by
PR+
tumors ( p - heterogeneity & lt ; 0.01 ) . -
pubmed
Household physical activity was inversely associated with
ER-/
PR-
tumors . -
pubmed
Novel Autosomal Recessive
c10orf2 Mutations Causing Infantile - Onset
Spinocerebellar Ataxia . -
pubmed
This genetically and phenotypically heterogeneous group includes infantile onset
spinocerebellar ataxia ( OMIM # 271245 ) a
neurodegenerative disease caused by mutations in the mtDNA helicase gene ,
c10orf2 , with an increased frequency in the Finnish population due to a founder mutation . -
pubmed
We describe a child of English descent who presented with a severe phenotype of
IOSCA as a result of two - novel mutations in the
c10orf2 gene . -
pubmed
Alternative
alpha - synuclein transcript usage as a convergent mechanism in
Parkinson ' s disease pathology . -
pubmed
alpha - Synuclein is implicated both in physiological functions at neuronal synaptic terminals as well as in pathological processes in the context of
Parkinson ' s disease . -
pubmed
Common variants in the
aSynL 3 ' untranslated region associated with
Parkinson ' s disease risk promote the accumulation and translation of
aSynL transcripts . -
pubmed
We demonstrate that the presence of the extended
aSynL transcript 3 ' untranslated region impacts accumulation of
alpha - synuclein protein , which appears redirected away from synaptic terminals and towards mitochondria , reminiscent of
Parkinson ' s disease pathology . -
pubmed
Taken together , these findings identify a novel mechanism for
aSyn regulation in the context of
Parkinson ' s disease - associated genetic and environmental variations . -
pubmed
About 10 % of all
ALS cases are familial ; approximately 20 % of
familial ALS cases are caused by mutations in the
superoxide dismutase 1 (
SOD1 ) gene . -
pubmed
We developed
rats that express a
human SOD1 transgene with
ALS - associated mutations , developing striking
motor neuron degeneration and
paralysis . -
pubmed
We administered
human recombinant
HGF (
hrHGF ) by continuous intrathecal delivery to the transgenic
rats at the onset of
paralysis for 4 weeks . -
pubmed
To translate this strategy to
human treatment , we induced a contusive cervical
spinal cord injury in the
common marmoset , a
primate , and then administered
hrHGF intrathecally . -
pubmed
These results prompted further clinical trials in
ALS using continuous intrathecal administration of
hrHGF . -
pubmed
While the down - regulated four genes ,
MAPK4 ,
FASN ,
INSIG1 and
SCD , were mainly linked to the endoplasmic reticulum and
fatty acid biosynthesis , these two cell processes that are associated with drug sensitivity by increasing evidences . -
pubmed
Transforming growth factor - beta and epithelial - mesenchymal transition are associated with pulmonary metastasis in
adenoid cystic carcinoma . -
pubmed
MATERIALS AND METHODS :
TGF - beta1 ,
phospho -
Smad2 and
beta - catenin expression in
ACC tissues derived from
patients was evaluated by immunohistochemistry . -
pubmed
RESULTS : Overexpression of
TGF - beta1 and
phospho -
Smad2 , and reduced expression of membrane
beta - catenin , were closely associated with lung metastasis in
ACC . -
pubmed
Blockade of
TGF - beta signaling by
TbetaRIIDN or siRNA may offer potential gene therapies against pulmonary metastasis in
patients with
ACC . -
pubmed
Glucose tolerance ,
insulin resistance ,
insulin secretory capacity , anthropometric measurements , lipid profiles , nutrient intakes and pregnancy outcomes were evaluated at 24 - 28 weeks of gestation . -
pubmed
Participants with the greater adherence to the DASH diet were 54 , 73 , 78 , and 80 % less likely to have enlarged waist circumference ,
hyperglyceridemia , low
HDL - C levels , and high blood pressure , respectively , compared with those in the lowest tertile . -
pubmed
The
sigma-2 receptors are promising therapeutic targets because of their significant upregulation in
tumor cells compared with normal tissue . -
pubmed
Adjustments of acute oral
rat toxicity values by simulating fractional absorption and
CYP - based metabolism as well as removing compounds with hydrolyzable linkages or flagged as substrates for glucuronidation delineated an upper boundary for
rat oral toxicity versus MMP . -
pubmed
CONCLUSION : CA - MRSA was the leading cause of
BJI and was associated with higher
CRP on admission , later normalization and longer treatment duration . -
pubmed
Anti -
Phospholipase A2 Receptor Antibody as Prognostic Indicator in
Idiopathic Membranous Nephropathy . -
pubmed
BACKGROUND : Anti -
phospholipase A2 receptor antibody (
PLA2R - Ab ) is useful in diagnosing
idiopathic membranous nephropathy (
IMN ) . -
pubmed
We investigated the clinical relevance of
PLA2R - Ab enzyme - linked immunosorbent assay ( ELISA ) in
patients with
IMN . -
pubmed
METHODS : We measured
PLA2R - Ab with an ELISA kit from the serum of 160
patients with
IMN ( n = 93 ) , secondary
MN ( n = 14 ) and other
glomerulonephritis ( n = 41 ) as well as healthy controls ( n = 12 ) at the time of renal biopsy and investigated the correlation of titers of
PLA2R - Ab with clinical parameters . -
pubmed
RESULTS :
PLA2R - Ab was positive in 41 of 93
patients ( 44.1 % ) with
IMN . -
pubmed
The
PLA2R - Ab titer positively correlated with
proteinuria and was negatively associated with renal function and
serum albumin . -
pubmed
CONCLUSION : The presence , as well as a high titer , of
PLA2R - Ab on ELISA was associated with poor prognosis of
IMN . -
pubmed
Although endocrinologists and
diabetes specialists will continue to maintain expertise in this field , it behooves the primary care physician to have a working knowledge of
insulin pumps and sensors to ensure optimal clinical care and decision - making for their patients . -
pubmed
Additionally , systemic therapy ( including
steroids and
calcineurin inhibitors ) may contribute to decreases in TFH cells in
patients with
cGVHD . -
pubmed
Inhibition of
CaMKII Attenuates Progressing Disruption of
Ca ( 2 + ) Homeostasis Upon Left Ventricular Assist Device Implantation in
Human Heart Failure . -
pubmed
The fact that
CaMKII inhibition reduces the SR -
Ca ( 2 + ) leak in
HF - Tx suggests that
CaMKII inhibition may be a promising option to beneficially influence clinical course after LVAD implantation . -
pubmed
This study sought to determine frequency , specificity and level of Ab to
VAR2CSA produced in children and whether children with
hyperparasitaemia and
severe malaria are more likely to produce Ab to
VAR2CSA compared to healthy children . -
pubmed
METHODS : Antibody responses to a panel of recombinant proteins consisting of multiple
VAR2CSA Duffy - binding - like domains ( DBL ) and full - length
VAR2CSA (
FV2 ) were characterized in 193 1 - 15 year old children from rural Cameroonian villages and 160 children with
severe malaria from the city . -
pubmed
Children with severe forms of
malaria had significantly higher
IgG to merozoite
antigens ( all p & lt ; 0.05 ) , but not to
VAR2CSA ( all p & gt ; 0.05 ) when compared to the healthy children . -
pubmed
CONCLUSION : The study suggests that children , including teenage girls acquire Ab to
VAR2CSA domains and FV2 , but Ab levels are much lower than those needed to protect women from
placental infections and repertoire of Ab responses to DBL domains is different from those in pregnant women . -
pubmed
Interestingly , children with
severe malaria did not have higher Ab levels to
VAR2CSA compared to healthy children . -
pubmed
Huntington ' s disease is a fatal
autosomal genetic disorder characterized by an expanded
glutamine - coding CAG repeat sequence in the
huntingtin (
Htt ) exon 1 gene . -
pubmed
PTEN ,
KRAS and
PIK3R1 were the most frequently mutated canonical
cancer - related genes . -
pubmed
In a
rat skin wound model , miR-149 improved the quality of the arrangement of
collagen bundles and reduced inflammatory cell infiltration during skin
wound healing . -
pubmed
Pingyangmycin Pretreatment Influences the Biological Behavior of
Ocular Venous Malformation and Relates with
Galectin-3 Expression . -
pubmed
BACKGROUND :
Galectin-3 (
Gal-3 ) plays a role in the mechanisms underlying
ocular venous malformation . -
pubmed
We conducted this study to investigate the effect of
pingyangmycin pretreatment on the
Gal-3 expressions and biological behavior of
ocular venous malformation . -
pubmed
CONCLUSIONS :
Gal-3 expression may be involved in the development and invasiveness of
ocular venous malformation , and
pingyangmycin can inhibit
Gal-3 expression , indicating a role of
pingyangmycin treatment before the removal of
ocular venous malformation . -
pubmed
Aspartate transaminase (
AST ) and
alanine transaminase (
ALT ) increased continuously until the diagnosis of complication in both stricture and rejection groups with more rapid increase in enzymes in the rejection versus
stricture group ( P & lt ; .05 ) . -
pubmed
The increasing slope and final levels of
AST and ALT are potentially helpful parameters to differentiate rejection and
stricture , the 2 most common posttransplantation complications . -
pubmed
Multivariate analysis showed T stage , N stage ,
insulinoma and
Ki-67 index were independent predictors of recurrence ( P & lt ; 0.05 ) . -
pubmed
Intracellular
galectin-7 expression in
cancer cells results from an autocrine transcriptional mechanism and endocytosis of extracellular
galectin-7 . -
pubmed
The
beta - galactoside binding protein
galectin-7 (
gal-7 ) is constitutively expressed at abnormally high levels in the outside milieu and intracellular compartments of many types of
epithelial cancer cells , most notably in aggressive forms of
ovarian and breast cancer . -
pubmed
Taken together , these findings reveal the existence of a positive self - amplification pathway that regulates intracellular
gal-7 expression in
breast and ovarian cancer cells . -
pubmed
TSSC6 KO
mice treated with
clopidogrel exhibited synergy in delayed kinetics of clot retraction , reduced
collagen - mediated
platelet aggregation , and platelet spreading on
fibrinogen . -
pubmed
Platelets derived from
TSSC6 mice with
P2Y12 blockade form smaller
thrombi when perfused over a
collagen matrix under arterial flow . -
pubmed
Clopidogrel treated
TSSC6 KO arterioles showed smaller and less stable
thrombi with increased tendency to embolise in vivo . -
pubmed
These studies demonstrate a complementary role between
TSSC6 and
P2Y12 receptor in platelets in regulating ' outside in '
integrin alphaIIbbeta3 signalling
thrombus growth and stability . -
pubmed
METHODS : The infants of
insulin - dependent , pregestational
diabetic mothers were identified in the daily review of the medical records of each newborn infant with a malformation and her / his mother 's medical record . -
pubmed
In this review article , we made comprehensive literature survey emphasising on
donepezil template which was structurally converted into plethora of MTLDs preserving anti -
cholinesterase effect and , at the same time , escalating the anti - oxidant potential , which was reported as a crucial role in the pathogenesis of the
Alzheimer ' s disease . -
pubmed
Isoliquiritigenin Ameliorates Acute
Pancreatitis in
Mice via Inhibition of Oxidative Stress and Modulation of the
Nrf2 /
HO-1 Pathway . -
pubmed
Taken together , our data for the first time confirmed the protective effects of
ISL on
AP in
mice via inhibition of oxidative stress and modulation of the
Nrf2 /
HO-1 pathway . -
pubmed
A Ketogenic Diet Reduces Central
Obesity and Serum
Insulin in Women with
Ovarian or Endometrial Cancer . -
pubmed
Objective : We hypothesized that a
KD would improve body composition and lower serum
insulin and
insulin - like growth factor - I (
IGF - I ) in women with
ovarian or endometrial cancer . -
pubmed
Visceral fat mass and fasting serum
insulin also are reduced by the
KD , perhaps owing to enhanced
insulin sensitivity . -
pubmed
The
angiotensin II / AT1 receptor pathway mediates
malaria - induced acute kidney injury . -
pubmed
Here , we investigated the potential role of the
angiotensin II ( Ang II )/ AT1 receptor pathway in the development of
MAKI . -
pubmed
PbA - infected
mice also presented
proteinuria and a high level of urinary
gamma - glutamyltransferase activity associated with an increase in
collagen deposition and interstitial space , showing tubule - interstitial injury . -
pubmed
Our data allow us to postulate that the
Ang II / AT1 receptor pathway mediates an increase in renal pro - inflammatory cytokines , which in turn leads to the
glomerular and tubular injuries observed in
MAKI . -
pubmed
It was shown that the mechanism of cell death caused by BRET - induced
phototoxicity of mimiSOG in the presence of
furimazine depends on the intracellular localization of the NanoLuc -
miniSOG fusion protein : BRET - mediated activation of
miniSOG in mitochondrial localization causes apoptosis , while the membrane localization of PS causes
necrosis of
cancer cells . -
pubmed
Mevalonate - derived products are also essential for the
Hedgehog pathway ,
steroid hormone signaling , and the nuclear localization of
Yes - associated protein and transcriptional co - activator with PDZ - binding motif , all of which playing roles in tumorigenesis and
cancer stem cell function . -
pubmed
Clinical application of statins is marred by dose - limiting toxicities and mixed outcomes on
cancer risk , survival and mortality , partially resulting from the statin - mediated compensatory upregulation of
HMGCR and indiscriminate inhibition of
HMGCR in normal and
tumor cells . -
pubmed
Tumor HMGCR is resistant to the
sterol - mediated transcriptional control ; consequently ,
HMGCR is upregulated in
cancers derived from adrenal gland , blood and lymph , brain , breast , colon , connective tissue , embryo , esophagus , liver , lung , ovary , pancreas , prostate , skin , and stomach . -
pubmed
Nevertheless ,
tumor HMGCR remains sensitive to
isoprenoid - mediated degradation . -
pubmed
In this study , we report nuclear magnetic resonance ( NMR ) based metabolomic analysis of surgically resected
tumors from forty five
pituitary tumor patients [ gonadotropic (
LH /
FSH - secreting ) = 17 ;
prolactinomas ( PRL - secreting ) = 11 ,
Cushing ' s disease (
ACTH - secreting ) = 4 , non - functional = 5 , and mixed = 8 ] who underwent transsphenoidal selective adenomectomy . -
pubmed
Compared to
LH /
FSH - secreting
tumors ,
PRL - secreting
tumors showed statistically significant decrease in the levels of
N - acetylaspartate (
NAA ) ,
myo - inositol ( mI ) ,
scyllo - inositol (
sI ) ,
glycine ,
taurine ,
phosphoethanolamine ( PE ) and increase in the levels of
glutamine . -
pubmed
When compared with
LH /
FSH - secreting
tumors ,
ACTH - secreting
tumors showed statistically significant decrease in the levels of sI ,
glycine , PE and increase in the levels of
aspartate . -
pubmed
Although lipid extracts of PAs showed the presence of many common lipid molecules , only
glycerophosphoethanolamine (
GPE ) showed statistically significant decrease in
PRL ,
ACTH and non - functional subtypes when compared to
LH /
FSH - secreting
tumors . -
pubmed
Hydroxymethylene diphosphonate for imaging
transthyretin cardiac amyloidosis . -
pubmed
Future clinical and biochemical predictions of
Fabry disease in females by methylation studies of the
GLA gene . -
pubmed
Fabry disease is an
X - linked lysosomal storage disorder caused by a
deficiency of alpha - galactosidase A (
alpha - gal A ) . -
pubmed
We previously reported that one heterozygous
Fabry female showing classical phenotypes had complete methylation of the non - mutated allele of the
GLA gene . -
pubmed
The mitochondrial transporter
uncoupling protein 2 (
UCP2 ) controls cell proliferation in vitro through the modulation of cellular metabolism , but the underlying mechanism in
tumors in vivo remains unexplored . -
pubmed
Using
murine intestinal cancer models and
CRC patient samples , we find higher
UCP2 protein levels in
tumors compared to their non - tumoral counterparts . -
pubmed
Mechanistically ,
UCP2 loss increases levels of
oxidized glutathione and proteins in
tumors . -
pubmed
We show that
UCP2 loss renders colon cells more prone to malignant transformation through metabolic reprogramming and perturbation of redox homeostasis and could favor worse outcomes in
CRC . -
pubmed
Metformin attenuates
PD - L1 expression through activating Hippo signaling pathway in
colorectal cancer cells . -
pubmed
In colorectal
carcinoma (
CRC ) ,
PD - L1 expression results in immune escape and poor prognosis . -
pubmed
After silencing or inhibiting
YAP1 expression by
Verteporfin ( VP ) , the inhibitor of
YAP1 , the expression of
PD - L1 were decreased in protein level in
CRC cells . -
pubmed
Compared with the control group ,
PD - L1 and
YAP1 expressions in
tumor tissues , detected by immunohistochemistry , were reduced in the group of
metformin treatment . -
pubmed
These findings illuminate a new regulatory mechanism ,
metformin activates Hippo signaling pathway to regulate
PD - L1 expression and suggests that
metformin has the possibility to increase the efficacy of immunotherapy in
human CRC . -
pubmed
Erythropoietin Alleviates
Burn - induced
Muscle Wasting . -
pubmed
We hypothesized
EPO could attenuate
burn - induced
muscle fiber atrophy . -
pubmed
Methods :
Rats were allocated into four groups : a sham
burn group , an untreated
burn group subjected to third degree hind paw
burn , and two
burn groups treated with weekly or daily
EPO for four weeks . -
pubmed
Results :
EPO attenuated the reduction of mean myofiber cross - sectional area post -
burn and the level of the protective effect was no significant difference between two
EPO - treated groups ( p=0.784 ) . -
pubmed
Furthermore ,
EPO decreased the expression of
atrophy - related ubiquitin ligase ,
atrogin-1 , which was up - regulated in response to
burn . -
pubmed
Compared to untreated
burn rats , those receiving weekly or daily
EPO groups had less cell apoptosis by TUNEL assay . -
pubmed
EPO decreased the expression of
cleaved caspase 3 ( key factor in the
caspase - dependent pathway ) and
apoptosis - inducing factor ( implicated in the
caspase - independent pathway ) after
burn . -
pubmed
Furthermore ,
EPO alleviated connective tissue overproduction following
burn via
transforming growth factor beta 1 -
Smad2 / 3 pathway . -
pubmed
Daily
EPO group caused significant
erythrocytosis compared with untreated
burn group but not weekly
EPO group . -
pubmed
Conclusion :
EPO therapy attenuated skeletal muscle apoptosis and
fibrosis at four weeks post -
burn . -
pubmed
Weekly
EPO may be a safe and effective option in
muscle wasting post -
burn . -
pubmed
Within the V - A ECMO group , there was no significant association between extreme
hyperoxia and in - hospital mortality ( P = 0.19 ) , duration of mechanical ventilation ( P = 0.63 ) , or
troponin levels ( P = 0.16 ) in the first 24 hrs . -
pubmed
RESULTS : Advancing age , manufacturing profession , history of
cerebrovascular disease , higher
cardiovascular disease burden ,
diabetes , slower walking speed , higher number of medications , and the
APOE epsilon4 allele were associated with accelerated odor identification decline ( ps < 0.014 ) . -
pubmed
Efficacy and safety of a
sodium - glucose co - transporter-2 inhibitor vs placebo as an add - on therapy for
people with
type 2 diabetes inadequately treated with
metformin and a
dipeptidyl peptidase-4 inhibitor : a systematic review and meta - analysis of randomized controlled trials . -
pubmed
AIMS : To conduct a systematic review and meta - analysis to assess the efficacy , safety and tolerability of
sodium - glucose co - transporter-2 inhibitors vs placebo as add - on therapy after
metformin and
dipeptidyl peptidase-4 inhibitor dual therapy in
type 2 diabetes . -
pubmed
Genital infections ( odds ratio 7.37 , 95 % CI 3.06 , 17.76 ; P < 0.00001 ) were more common with
sodium - glucose co - transporter-2 inhibitors , but there was no significant statistical difference in
urinary tract infections ( odds ratio 1.16 , 95 % CI 0.63 , 2.13 ; P=0.64 ) , in
hypoglycaemia ( odds ratio 1.36 , 95 % CI 0.61 , 3.04 ; P = 0.45 ) , or in discontinuation rates due to adverse events ( odds ratio 1.52 , 95 % CI 0.78 , 2.97 ; P=0.22 ) between the two groups . -
pubmed
CONCLUSIONS : In comparison with placebo , add - on therapy with a
sodium - glucose co - transporter-2 inhibitor is significantly more efficacious in lowering HbA1c , fasting plasma
glucose and weight in
people with
type 2 diabetes following inadequate glycaemic control with
metformin and a
dipeptidyl peptidase-4 inhibitor . -
pubmed
Maternal
Prenatal Depression in Pregnancies With Female and Male Fetuses and Developmental Associations With
C - reactive Protein and
Cortisol . -
pubmed
Maternal
C - reactive protein levels were significantly associated with
depression only in pregnancies with male fetuses and with decreased newborn
P50 inhibition only in male newborns . -
pubmed
Maternal
cortisol levels were significantly associated with
depression only in pregnancies with female fetuses and with decreased newborn
P50 inhibition only in female newborns . -
pubmed
CONCLUSIONS : This study finds sex - specific associations of
C - reactive protein and
cortisol levels with prenatal
depression in
women and with decreased development of newborn P50 inhibition . -
pubmed
Decreased newborn
P50 inhibition is associated with later childhood behavioral problems , and decreased
P50 inhibition is a pathophysiological feature of several
mental illnesses . -
pubmed
Novel allosteric
PARP1 inhibitors for the treatment of
BRCA - deficient leukemia . -
pubmed
The successful use of
PARP1 inhibitors like
olaparib (
Loparza ) in the treatment of
BRCA1 / 2 - deficient breast cancer has provided clinical proof of concept for applying personalized medicine based on synthetic lethality to the treatment of
cancer . -
pubmed
NMDAR antibody
encephalitis overlapping with
CLIPPERS syndrome in a
psoriasis patient on adalimumab . -
pubmed
alpha1 - Fetoprotein measurement in blood spotted on paper : discriminating test for
hereditary tyrosinemia in neonatal mass screening . -
pubmed
The comparative value of serum neutralization , hemadsorption inhibition and immunofluorescence reactions in the diagnosis of
PI-3 and IBR
viral infections of calves ] . -
pubmed
Decreased fidelity of
DNA polymerase activity during
N-2 - fluorenylacetamide hepatocarcinogenesis . -
pubmed
Performance of the
mucinous - like carcinoma - associated antigen in
serous effusions . -
pubmed
The
mucinous - like carcinoma - associated antigen (
MCA ) , a new
tumour marker , was dosed in 150
serous effusions . -
pubmed
Systemic lymphoblastoid
interferon therapy in
chronic progressive multiple sclerosis . -
pubmed
Immunologic functions are studied in conjunction with a placebo - controlled trial of
lymphoblastoid interferon (
IFN ) in
patients with chronic progressive (
CP )
multiple sclerosis . -
pubmed
Prior to treatment ,
CD4 + cells are significantly increased and
CD8 + cells decreased in the blood of
MS patients . -
pubmed
Although these immune functions may identify a number of
CP MS patients who might benefit from
IFN , it is unlikely that these mechanisms actually mediate the potentially beneficial effects of this
cytokine . -
pubmed
Pneumococci and
Haemophilus are still the two most prevalent pathogens in
acute otitis media and raise problems regarding susceptibility : 25 % of Haemophilus beta - strains produce
beta - lactamases and 6 to 12 % of pneumococci are intermediate or resistant to
penicillin . -
pubmed
The new oral third generation
cephalosporins are effective in
infections due to
beta - lactamase - producing Haemophilus strains . -
pubmed
The efficiency of an ELISA method , designed to detect polyvalent
IgG and
IgM antibodies to
Salmonella typhi polysaccharide was evaluated in patients admitted or convalescing from
typhoid fever and in control subjects . -
pubmed
These results and additional immunoblotting tests suggest that ELISA developed to detect polyvalent
anti - LPS antibodies could represent a highly specific diagnostic tool to confirm
typhoid fever in endemic areas . -
pubmed
Effects of late administration of
tissue - type plasminogen activator on left ventricular remodeling and function after
myocardial infarction . -
pubmed
The beneficial effect of late thrombolysis with
rt - PA may be related to a reduction in myocardial expansion and thus to a favorable influence on
postinfarction left ventricular remodeling . -
pubmed
Expression of
transforming growth factor alpha in
human gliomas . -
pubmed
Expression of
transforming growth factor alpha (
TGF alpha ) is frequently associated with the development of
human and animal
tumors . -
pubmed
Using a sensitive immunohistochemical assay , which can be applied on
formalin - fixed , paraffin - embedded tissue , we have examined the expression of
TGF alpha in 71
human gliomas ( 63 untreated and 8 recurrent
tumors ) . -
pubmed
A strong positive correlation between
tumor grade and extent of
TGF alpha expression was found ( P less than 0.0001 ) . -
pubmed
Similarly , using
TNF - specific antibody reagents , TNF - secreting cells were detected and quantitated in cell populations obtained from
normal lymphoid tissues , bone marrow and peripheral blood , following activation with
phorbol myristate acetate and
ionomycin . -
pubmed
Elevated serum
lactate dehydrogenase occurred mainly in
IG and HG
lymphomas and was an important prognostic factor . -
pubmed
The action of
opiate receptor agonists :
( D - Ala2 )- methionine enkephalinamide (
D - MEA ) ,
morphine ,
heroin ,
etorphine , and antagonists :
naloxone and
diprenorphine on
audiogenic seizures was tested during
ethanol abstinence . -
pubmed
This mechanism is quantifiable by the
plasma renin level or the
hypotensive response to an antirenin - system drug ( converting enzyme inhibitor , beta blocker or
saralasin ) . -
pubmed
The lateral diffusion of
lectin - labelled glycoconjugates was studied in the
human colon carcinoma cell line
HT29 using fluorescence photobleaching techniques . -
pubmed
The circadian variation of
thyrotrophin in
patients with
primary thyroidal disease . -
pubmed
It was found that some
patients with
hyperthyroidism and suppressed basal
TSH levels exhibited a 24 h secretory pattern similar to that seen in normal
subjects with peak
TSH levels occurring at night . -
pubmed
In addition two
subjects with a
euthyroid multinodular goitre demonstrated levels of
TSH below the normal range despite being clinically and biochemically euthyroid . -
pubmed
TSH suppression in these
subjects is probably related to some degree of thyroid autonomy and possible development of
hyperthyroidism in the future . -
pubmed
Uptake of a monoclonal antibody against
CEA ( Tumak 431/31 ) in a
human colon tumor (
Co-112 ) xenografted in the
nude mouse . -
pubmed
A monoclonal antibody ( Tumak ) against
carcinoembryonic antigen (
CEA ) was injected into
nude mice bearing a
human colon carcinoma ( Co-112 ) . -
pubmed
To this end , the metabolic fates of a small protein ,
lambda - L chain ( mol wt 44,000 ) , and a protein of intermediate size ,
IgG ( mol wt 160,000 ) , were studied in controls and
patients with
renal disease . -
pubmed
Patients with
renal tubular disease had a 50 - fold increase in the daily urinary excretion of 15 - 40,000 molecular weight proteins such as
lysozyme and
lambda - L chains . -
pubmed
Serum
IgG and
lambda - L chain survivals were normal ; however , the fraction of the over - all
lambda - L chain metabolism accounted for by
proteinuria was increased 40 - fold whereas endogenous catabolism was correspondingly decreased . -
pubmed
Patients with the
nephrotic syndrome had a slight increase in
lambda - L chain survival whereas
IgG survival was decreased and the fraction of
IgG lost in the urine was markedly increased . -
pubmed
Patients with
uremia had a normal
IgG survival but a four to 10 - fold prolongation of
lambda - L chain survival due to loss of entire nephrons , the major site of metabolism of these proteins . -
pubmed
This results in an increase ( up to 10 - fold ) in the serum concentration of
lambda - L chain ,
lysozyme , and other small biologically active proteins , a phenomenon that may be of importance in causing some of the manifestations of the
uremic syndrome . -
pubmed
[ Evaluation of circulating immune complexes in
leprosy in relation to clinical activity , antileprosy agents ,
bacterial indices and
anti - DNA antibodies ] . -
pubmed
[ Limits of
insulin therapy in
type II diabetes ] . -
pubmed
Human dopamine - beta - hydroxylase : comparison of the enzyme from plasma , adrenal medulla , and
pheochromocytoma by radioimmunoassay . -
pubmed
Low - dose
aspirin does not prevent
thrombovascular accidents in low - risk haemodialysis
patients during treatment with recombinant
human erythropoietin . -
pubmed
Treatment of the
anaemia of
renal disease with
recombinant human erythropoietin results in an improvement of haemostasis and an increased risk of
thrombovascular accidents . -
pubmed
In this prospective , placebo - controlled , double - blind , and cross - over study , the effects of low - dose
acetylsalicylic acid ( 30 mg daily ) on
thrombotic and
bleeding events during the initial period of treatment with
erythropoietin in
anaemic haemodialysis
patients without previous
thrombovascular accidents or known increased risk for
thrombosis were investigated . -
pubmed
In conclusion ,
erythropoietin treatment resulted in a reduction of the
bleeding time . -
pubmed
Distal accentuation of conduction slowing in
polyneuropathy associated with antibodies to
myelin - associated glycoprotein and
sulphated glucuronyl paragloboside . -
pubmed
In four
patients with a chronic , demyelinating
polyneuropathy associated with
monoclonal IgM antibodies to
myelin - associated glycoprotein (
MAG ) and
sulphated glucuronyl paragloboside (
SGPG ) , we have observed a marked prolongation of distal motor latencies disproportionate to proximal segment - conduction velocities , in nearly all nerves studied . -
pubmed
Sixteen of 21 nerves ( 76 % ) studied in the
patients with anti -
MAG /
SGPG polyneuropathy had a terminal latency index of & lt ; or = 0.25 versus 11 of 195 nerves ( 6 % ) of
Charcot - Marie - Tooth polyneuropathy type 1A patients , three of 49 nerves ( 6 % ) of
patients with
chronic inflammatory polyneuropathy and none of the controls ( P = 0.0001 ) . -
pubmed
Recognition of this unique pattern of generalized , distally predominant conduction slowing in anti -
MAG /
SGPG polyneuropathy may be useful in clinically distinguishing this from other
chronic demyelinating polyneuropathies , and in possibly providing insights into the pathophysiology of this disorder . -
pubmed
In addition , analysis of the restriction maps of
T cell receptor ( TRC )- beta , demonstrated that an oligoclonal population of T cells was preselected in vivo , near the
tumour site , and might be expanded in vivo , using
phytohaemagglutin and
interleukin 2 while maintaining the same characteristics of the original population . -
pubmed
Remission maintenance therapy with
histamine and
interleukin-2 in
acute myelogenous leukaemia . -
pubmed
The
IL-2 - induced killing of
AML blasts was inhibited by monocytes , recovered from peripheral blood by centrifugal elutriation . -
pubmed
Histamine , of concentrations within the micromolar range , abrogated the monocyte - induced inhibition of NK - cells ; thereby ,
histamine and
IL-2 synergistically induced NK - cell - mediated killing of
AML blasts . -
pubmed
Based on these in vitro findings , seven
patients with
AML in first ( n=2 ) , second ( n=3 ) or third ( n=2 ) complete remission ( CR ) were given home therapy with
interleukin-2 (
IL-2 ; O.9 x 10(6 ) IU x 2 s.c . ) -
pubmed
Toxicity was moderate and include local reactions to
IL-2 at the site of injection and short - lasting flush ,
hypotension , and
headache to
histamine . -
pubmed
We conclude that ( i )
histamine and
IL-2 synergize to kill
human AML blasts in vitro , and ( ii )
histamine /
IL-2 is a safe and feasible approach to immunotherapy of
AML which merits further investigation . -
pubmed
A colorimetric immunoassay for the detection of
E - cadherin and
carcinoembryonic antigen (
CEA ) expression on
human colon carcinoma cell lines in vitro . -
pubmed
An immunohistochemical assay , using 96 - well microtiter plates and based on the
avidin -
biotin peroxidase reaction , was developed for the quantitation of
E - cadherin and
CEA expression on
HT-29 and
SW620 colon carcinoma cells . -
pubmed
Collagen and glycosaminoglycans of
Wharton ' s jelly and their alterations in
EPH - gestosis . -
pubmed
For these reasons the role of
collagen and glycos - aminoglycans ( GAGs ) of
UC in pathobiochemistry of this syndrome seems to be important . -
pubmed
We studied histology of extracellular matrix components , quantity , solubility and molecular polymorphism of
collagen , proportional relationships between various types of
collagen , the amounts of GAGs and proportional relationships between them in Wharton 's jelly of control newborns delivered by healthy mothers and those delivered by mothers with
EPH - gestosis . -
pubmed
Acute effects of
bromocriptine ,
cyproheptadine , and
valproic acid on
plasma adrenocorticotropin secretion in
Nelson ' s syndrome . -
pubmed
Previous studies have found that
bromocriptine ,
cyproheptadine , and
valproic acid can reduce
ACTH secretion in
Nelson ' s syndrome , but none of these agents has achieved widespread use due to their failure to normalize
ACTH in most
patients . -
pubmed
We conclude that at the doses studied ,
bromocriptine had the greatest acute effect in suppressing
ACTH secretion in
Nelson ' s syndrome , and that combined administration with
valproic acid and
cyproheptadine did not further increase this acute
ACTH - suppressive effect . -
pubmed
Prenatal diagnosis of
carbamoyl phosphate synthetase I deficiency by identification of a missense mutation in
CPS1 . -
pubmed
Potential drugs against
cervical cancer :
zinc - ejecting inhibitors of the
human papillomavirus type 16 E6 oncoprotein . -
pubmed
Current therapeutic strategies aim at the inhibition of activation of platelets and the coagulation cascade and the suppression of
platelet aggregation and
fibrin formation . -
pubmed
Figure 2 shows the mechanism of action of the
GP - IIb / IIIa blockers on
platelet aggregation . -
pubmed
The aetiological agent of
prion disease is proposed to be an aberrant isoform of the cell surface glycoprotein known as the
prion protein (
PrP ( c ) ) . -
pubmed
Neurodegeneration in these disease has been shown to be associated with accumulation of
PrP(Sc ) in affected tissue . -
pubmed
To investigate the possible uptake mechanisms that may be required for
PrP(Sc)-induced neurodegeneration we studied the cellular trafficking of the
neurotoxic fragment ,
PrP106 - 126 . -
pubmed
The data obtained suggest that the fatal changes in brain tissue associated with the
prion diseases , are initiated by a conformational rearrangement of constitutively expressed cellular protein
PrP. -
pubmed
A pharmacokinetic study of
cyanamide , an inhibitor of
aldehyde dehydrogenase (
EC1.2.1.3 ) used as an adjuvant in the aversive therapy of
chronic alcoholism , has been carried out in healthy
male volunteers following intravenous and oral administration . -
pubmed
The results obtained imply that genetic alterations that both impair
p53 function and deregulate
E2F-1 expression may render hematopoietic cells refractory to the induction of differentiation and are , thereby , likely to play a major role in the progression of
leukemias . -
pubmed
The role of
beta - amyloid (
Abeta ) in
neuron dysfunction in the initiation stage may be mediated through alterations in signal transduction pathways involving
cyclic AMP response element binding protein (
CREB ) . -
pubmed
METHOD : In a group of 25
type 1 diabetics selected at random ( 12
women and 13
men ) , mean age 40.5 years + /- 11.6 SD ( range 21 to 57 years ) with a duration of
diabetes of 17.8 + /- 7.9 years ( minimum 4 , maximum 35 years ) with a mean value of glycosylated
haemoglobin of 8.71 % + /- 1.82 ( minimum 7.2 , maximum 12.2 % ) the authors assessed : the time of gastric emptying by scintigraphic follow up of the progress of solid food (
rice labelled with
99mTc ) . -
pubmed
The correlation of gastric emptying and time factors ( age , duration of
diabetes ) and metabolic factors ( blood
sugar level ,
glycosylated haemoglobin ) . -
pubmed
The level of
CRP is related to the level of
albumin , suggesting that
inflammation is related to nutritional status . -
pubmed
The level of
homocysteine is associated with the level of
von Willbrand factor , suggesting that
homocysteine is related to
endothelial injury . -
pubmed
Study of the
BtK gene enabled differential diagnosis with common variable
immunodeficiency disease in some patients who showed absent or very low lymphocyte B counts as well as forms of
autosomal recessive agammaglobulinemia . -
pubmed
Using the same techniques , we were able to identify mutations in the
CD40 ligand gene in three families in which one of the members had clinical and biological phenotype compatible with
X - linked hyper - IgM. -
pubmed
Tumour necrosis factor microsatellites and
HLA - DRB1 * ,
HLA - DQA1 * , and
HLA - DQB1 * alleles in Peruvian patients with
rheumatoid arthritis . -
pubmed
OBJECTIVE : To study the association between
rheumatoid arthritis (
RA ) and
HLA and
tumour necrosis factor (
TNF ) polymorphism in Peruvian mestizo patients in comparison with ethnically similar controls . -
pubmed
METHODS : Seventy nine patients with
RA and 65 ethnically matched healthy controls were genotyped for
HLA - DRB1 ,
HLA - DQA1 ,
HLA - DQB1 , and
TNFalpha and
TNFbeta alleles using PCR amplification . -
pubmed
CONCLUSIONS : This study shows for the first time that
TNF gene polymorphism is associated with susceptibility to
RA in a non - white population . -
pubmed
We and others reported increased abundance of catalytically impaired
PTP-1B in tissue lysates from
obese human subjects with and without
type 2 diabetes , while genetic knockout of
PTP-1B improves
insulin sensitivity and prevents nutritionally mediated
insulin resistance and
obesity . -
pubmed
Ad5 treatment did not result in a statistically or clinically significant
liver injury , as determined by serum
alanine aminotransferase and histological examination . -
pubmed
Seven days post injection , no significant difference in rate of
weight gain , fasting blood
glucose or
insulin levels were seen in any group . -
pubmed
A
glutamate residue at the C terminus regulates activity of
inward rectifier K + channels : implication for
Andersen ' s syndrome . -
pubmed
Expression and distribution of
pituitary adenylate cyclase - activating peptide in
human prostate and
prostate cancer tissues . -
pubmed
The presence , expression and distribution of
pituitary adenylate cyclase - activating peptide (
PACAP ) in
human prostate cancer and healthy tissue were investigated by means of biochemical and morphological procedures . -
pubmed
Immunohistochemistry on tissue sections indicated the location of
PACAP in the epithelial layer of prostate glands ( and in some scarce leucocytes ) but not in the stroma , either in
normal or
carcinomatous tissues . -
pubmed
These results are the first demonstration of the localization of
PACAP or its precursors and its mRNA in the
human prostate gland and their presence during the progression of
prostate carcinoma . -
pubmed
Inhibition of in vivo constriction of
fetal ductus arteriosus by
endothelin receptor blockade in
rats . -
pubmed
Dual
ET receptor antagonist (
bosentan ) and selective
ET - A blocker (
CI-1020 ) prevent constriction of the
fetal ductus arteriosus induced by ductus - constricting agents in
rats , indicating that ET and
ET - A receptors are essential in fetal ductal constriction . -
pubmed
[
Activated serine / threonine kinase AKT enhances the radioresistancy in
human cholangiocarcinoma ] . -
pubmed
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (
CADASIL ) is an
angiopathy caused by mutations in the
NOTCH3 gene . -
pubmed
We analyzed these data to determine whether
myocardial ischemia is associated with
NOTCH3 mutations . -
pubmed
To our knowledge , this is the first study showing that
NOTCH3 mutation carriers may be at increased risk of early
acute myocardial infarction , expanding
CADASIL disease expression beyond the central nervous system to include the heart . -
pubmed
Reduced fibrinolytic activity of
atherosclerotic sera caused by an increase in
low - density lipoproteins in blood . -
pubmed
Enhanced expression of
interleukin-8 and activation of
nuclear factor kappa - B in endoscopy - negative
gastroesophageal reflux disease . -
pubmed
Recent studies have shown that
IL-8 is likely involved in the development and progression of erosive
reflux esophagitis (
RE ) , yet little is known about its implication in endoscopy - negative
gastroesophageal reflux disease (
GERD ) . -
pubmed
The purpose of this study was to determine
IL-8 messenger ribonucleic acid ( mRNA ) expression levels in endoscopy - negative
GERD , along with assessment of
nuclear factor kappaB (
NF - kappaB ) activation , which upregulates
IL-8 expression . -
pubmed
In nine endoscopy - negative
GERD patients , the
IL-8 mRNA expression levels were measured before and 8 wk after treatment with
lansoprazole . -
pubmed
RESULTS : The relative
IL-8 mRNA expression levels were significantly higher in esophageal mucosa of
patients with endoscopy - negative
GERD than those of the controls . -
pubmed
The presence of basal zone
hyperplasia and intraepithelial neutrophils , histopathological hallmarks of
GERD , were associated with higher levels of
IL-8 mRNA . -
pubmed
The esophageal epithelium of
patients with
GERD showed intense immunoreactivity for
IL-8 , and expressed
CXCR-1 antigen . -
pubmed
We found
NF - kappaB activation in esophageal mucosa in
GERD patients and the
NF - kappaB subunits were localized predominantly in the nuclei of
IL-8 - expressing cells . -
pubmed
CONCLUSIONS : Our results demonstrate enhanced mucosal expression of
IL-8 in incipient
GERD even without mucosal breaks . -
pubmed
NF - kappaB activation may be implicated in the pathogenesis in
GERD . -
pubmed
Intravenous
leiomyomatosis of the uterus : a
GnRH agonist utilisation before surgery . -
pubmed
A synonymous coding polymorphism in the
alpha2 - Heremans - schmid glycoprotein gene is associated with
type 2 diabetes in French Caucasians . -
pubmed
The
AHSG gene , consisting of seven exons and spanning 8.2 kb of genomic DNA , is located at chromosome 3q27 , a susceptibility locus for
type 2 diabetes and the
metabolic syndrome . -
pubmed
These observations suggested that the
AHSG gene is a strong positional and biological candidate for
type 2 diabetes susceptibility . -
pubmed
We carried out a detailed genetic association study of the contribution of these common
AHSG SNPs to genetic susceptibility of
type 2 diabetes in French Caucasians . -
pubmed
Crosstalk of
beta - adrenergic receptor subtypes through
Gi blunts beta - adrenergic stimulation of
L - type Ca2 + channels in
canine heart failure . -
pubmed
The mechanisms underlying the blunted contractile response to
beta - adrenergic receptor (
beta - AR ) stimulation in
heart failure (
HF ) are incompletely understood , especially with regard to
beta - AR subtype - specific regulation of
L - type Ca2 + channels . -
pubmed
We evaluated the impact of
HF induced by pacing
tachycardia on
beta - AR regulation of
L - type Ca2 + channels in a
canine model . -
pubmed
Experiments testing
beta1 - AR- and
beta2 - AR - selective stimulation showed that the major component of the blunted response to nonselective
beta - AR stimulation in
HF was caused by
beta2 - AR activation , resulting in a
pertussis toxin - sensitive ,
Gi - mediated inhibition of the
beta1 - AR - induced increase in I(
Ca , L ) . -
pubmed
In conclusion ,
canine HF results in the following : ( 1 ) a uniform reduction in
beta1 - AR density in surface and T - tubule membrane fractions without a change in
beta2 - AR density ; and ( 2 ) the emergence of distinct
Gi - coupling to
beta2 - ARs resulting in accentuated antagonism of
beta1 - AR - mediated stimulation of
I ( Ca , L ) . -
pubmed
These results have implications for optimizing the use of
beta - AR drugs in
HF . -
pubmed
G - CSF stimulated islands of haematopoiesis mimicking disseminated malignancy on PET - CT and MRI scans in a
patient with
hypoplastic marrow disorder . -
pubmed
Our study suggests that the same quantitative trait locus on the chromosome 4 q region , where
ADH3 is located , may influence the risk of
alcoholism , variations of electroencephalogram , and the 4 ttdts of the event - related potential measures . -
pubmed
[ From the Cochrane Library and Diabetes Care : self - monitoring of blood
glucose probably an effective way to improve glycaemic control in patients with
type 2 diabetes not taking
insulin ] . -
pubmed
Self - monitoring of blood
glucose has been found to be effective for patients with
type I diabetes and for patients with
type 2 diabetes taking
insulin . -
pubmed
There is much debate on the effectiveness of self - monitoring of blood
glucose in the management of patients with
type 2 diabetes who are not taking
insulin . -
pubmed
A systematic review of 6 randomised controlled trials comparing self - monitoring of blood
glucose with standard care , self - monitoring of urine
glucose , or both showed that self - monitoring of blood
glucose may be effective in improving glycaemic control in
patients with
type 2 diabetes who are not using
insulin . -
pubmed
Bacillus anthracis edema toxin (
ET ) , composed of protective antigen and an
adenylate cyclase edema factor (
EF ) , elicits
edema in host tissues , but the target cells and events leading from EF - mediated
cyclic - AMP production to
edema are unknown . -
pubmed
Although the effects of
pyrilamine ,
cromolyn , or
aprepitant on ET - induced vascular leakage suggest a possible role for mast cells ( MC ) and sensory neurons in ET - induced
edema , ET did not elicit degranulation of
human skin MC or
substance P release from NT2N cells in vitro . -
pubmed
Endothelin 1 (
ET-1 ) produced abundantly by prostate cancer cells binds to its receptor present on bone marrow stromal cells and favors osteoblastic response during bone metastases of
prostate cancer . -
pubmed
This suggests that interrupting
ET-1 interaction with its
endothelin A ( ET ( A ) ) receptor could be useful for inhibiting
prostate cancer bone metastasis and , as such , may enhance the therapeutic activity of
docetaxel (
Taxotere ) , the most commonly used drug for the treatment of metastatic
prostate cancer . -
pubmed
Therefore , the goal of our study was to obtain preclinical data supporting our hypothesis that the combined use of
ET ( A ) receptor antagonist (
ABT-627 ;
Atrasentan ) with
Taxotere will be superior in inducing apoptosis in vitro and inhibiting
tumor growth in vivo in a
SCID - hu model of experimental bone metastasis induced by
C4 - 2b prostate cancer cells . -
pubmed
In vitro studies were done on a panel of
prostate cancer cell lines to understand the molecular basis of combination therapy , and we found that the combination was more effective in the inhibition of cell viability and induction of apoptosis in
LNCaP and
C4 - 2b cells (
androgen receptor positive ) but not in
PC-3 cells . -
pubmed
Tumor volume and
serum prostate - specific antigen were used as terminal index to evaluate the therapeutic advantage of combination therapy relative to a single regimen and untreated control . -
pubmed
[ Intrapleural
streptokinase in the treatment of complicated
parapneumonic empyema ] . -
pubmed
As the benefit of the new antiretroviral drug class of the
CCR5 coreceptor antagonists will be probably limited to the
HIV - infected patients harbouring R5 strains , determination of viral coreceptor tropism has become an important diagnostic prerequisite for the treatment of
HIV infection . -
pubmed
In the event of
intrauterine infection ,
lipoxygenase (
LOX ) metabolites are produced in the placenta and contribute to
preterm labor and adverse fetal outcomes . -
pubmed
Variable phenotype including
Leigh syndrome with a 9185T>C mutation in the
MTATP6 gene . -
pubmed
Following recent reports of this same mutation in a single case and in a family with late - onset
LS and NARP - like features , our paper emphasises the role of
MTATP6 in
LS and expands the associated clinical phenotype further . -
pubmed
Syndecan-1 expression in
gallbladder cancer and its prognostic significance . -
pubmed
AIM : To determine whether the immunohistochemical detection of
syndecan-1 could provide useful information as a novel therapeutic or prognostic factor in primary gallbladder ( GB )
cancer . -
pubmed
MATERIALS AND METHODS : Forty - three GB
cancer tissues were evaluated by immunohistochemistry for
syndecan-1 expression . -
pubmed
RESULTS : Epithelial
syndecan-1 immunoreactivity was observed in 25 ( 58.1 % ) of the 43
GB cancer cases . -
pubmed
The
tumors with a positive
syndecan-1 expression more frequently showed lymph node metastasis ( p = 0.037 ) . -
pubmed
Although there was no statistically significant association , the
tumors with a positive
syndecan-1 expression tended to show a deeper invasion depth ( p = 0.087 ) and more frequent lymphovascular invasion ( p = 0.064 ) . -
pubmed
CONCLUSIONS : A subset of GB
cancers revealed an epithelial overexpression of
syndecan-1 , which was associated with a progressive pathological feature and an aggressive clinical course . -
pubmed
Therefore , epithelial
syndecan-1 expression may be a predictor for a poor prognosis in
patients with GB
cancer . -
pubmed
Aprepitan , a
neurokinin-1 receptor antagonist , is a centrally active agent that might have the ability to decrease
hot flashes . -
pubmed
This study suggests that
neurokinin receptors do not play a major role in mediating
hot flashes . -
pubmed
The partial
dopamine D ( 2 ) receptor agonist
aripiprazole has recently been tested as a treatment for
stimulant and alcohol dependence in both
animal and clinical studies . -
pubmed
Interferon - gamma release assays do not identify more
children with active
tuberculosis than the tuberculin skin test . -
pubmed
A negative
interferon - gamma release assay should not dissuade paediatricians from diagnosing and treating presumed active
tuberculosis . -
pubmed
If used for diagnosis of
latent tuberculosis infection ,
interferon - gamma release assays could significantly reduce the numbers of children receiving chemoprophylaxis . -
pubmed
aureus (
MRSA ) isolates from device - related
infections with both
fnbA and
fnbB produced significantly more biofilm than isolates with either gene alone . -
pubmed
Under mildly acidic growth conditions ,
FnBP - mediated biofilm and
fnbA and
fnbB transcript levels were substantially higher during growth at 37 degrees C than at 30 degrees C. Thus , in addition to a lowered pH , carriage of both
fnbA and
fnbB and growth at 37 degrees C promote MRSA biofilm development , further supporting a role for the
FnBPA and
FnBPB surface proteins in the pathogenesis of
MRSA device - related infections . -
pubmed
Similar to the results for HMVEC - d cells ,
KSHV infection of
HUVEC cells also resulted in an initial high level and subsequent decline in the expression of the lytic switch gene ,
ORF50 , while latent gene expression persisted . -
pubmed
Interestingly ,
MPs from ischemic muscles produced more reactive
oxygen species and expressed significantly higher levels of
NADPH oxidase p47 ( 6 - fold ; P<0.05 ) and
p67 subunits ( 16 - fold ; P<0.001 ) than controls , whereas
gp91 subunit expression was unchanged . -
pubmed
The present study is the first to evaluate the expression and activity of
MnSOD ,
Cu /
ZnSOD and
catalase in
human gastric samples , since ROS play a significant role in the pathogenesis of different forms of
malignancy inducing mutations and various diseases such as
gastric cancer . -
pubmed
We found that
MnSOD activity was increased in
adenocarcinoma , CG and
HP tissues ( p<0.05 - 0.001 ) , while
Cu /
ZnSOD was significantly lower in
adenocarcinoma and
HP tissues ( p<0.001 ) when compared to the healthy control . -
pubmed
MnSOD and
Cu /
ZnSOD were expressed to a significantly higher degree in
adenocarcinoma and
HP tissues ( p<0.05 and & lt;0.001 respectively ) and to a significantly lower degree in
CG tissues with respect to the healthy
patients ( p<0.05 and & lt;0.001 ) . -
pubmed
A significant decrease in
CAT activity in
adenocarcinoma and
HP tissues was observed ( p<0.01 and & lt;0.05 ) . -
pubmed
However , immunohistochemistry ( IHC ) showed the
tumor cells to stain positively for
cytokeratin 20 , but not for
cytokeratin 7 , thus confirming the metastatic nature of the lesion . -
pubmed
No clear evidence for an association between
GH replacement and relapse of
intracranial germ cell tumours : single centre and KIMS experience . -
pubmed
Echinococcus multilocularis infection and
TNF inhibitor treatment in a patient with
rheumatoid arthritis . -
pubmed
Adequate
carbohydrate replacement before , during , and after exercise and reduction of preprandial rapid - acting
insulin doses are the main allies in avoiding severe
hypoglycemic events among
diabetic children and adolescents . -
pubmed
OBJECTIVE :
Bone morphogenetic proteins (
BMPs ) play important roles in the stimulation of osteogenesis and osteoinduction during bone
fracture healing and their expression levels may be important for bone graft efficacy . -
pubmed
Negative pressure wound therapy overlay technique with
collagen dressings for
nonhealing wounds . -
pubmed
BACKGROUND : Our clinical experience suggests that the effectiveness of negative pressure wound therapy is enhanced by adding
collagen alginate to the dressing regimen , applying foam over areas that are undermined or tunneled , and approximating and securing
wound edges prior to applying foam . -
pubmed
CONCLUSION : Our outcomes demonstrate the feasibility of this technique and suggest that
patients with significant wound size benefit from adding
collagen alginate to negative pressure wound therapy and by applying foam over areas that are undermined or tunneled and/or approximating and securing
wound edges prior to applying foam . -
pubmed
VEGFR1 expression is related to lymph node metastasis and serum
VEGF may be a marker of progression in the follow - up of
patients with
differentiated thyroid carcinoma . -
pubmed
The aim of the study was to examine the expressions and serum levels of
VEGF ,
VEGFR1 ,
IGF1 , and
IGF1 receptor (
IGF1R ) in
patients with
differentiated thyroid carcinoma (
DTC ) compared with
patients with
nodular goiter (
NG ) . -
pubmed
RESULTS : The immunostainings scores for
VEGF ,
VEGFR1 ,
IGF1 , and
IGF1R were found to be higher in
patients with
DTC than in those with
NG . -
pubmed
Serum
VEGF was found to be higher in
patients with progressive
DTC than in
patients in clinical remission . -
pubmed
Increased serum levels of
VEGF may reflect disease recurrence in
DTC . -
pubmed
It has been suggested that initial
collagen contraction and thermal damage modulate
wound healing . -
pubmed
Microsomal epoxide hydroxylase genotypes / diplotypes , traffic air pollution , and childhood
asthma . -
pubmed
We investigated the associations of
EPHX1 Tyr113His and His139Arg polymorphisms with
asthma and
wheezing outcomes , and focused on the functional genetic change in different ambient
nitrogen dioxide (
NO2 ) levels on
glutathione S - transferase p1 (
GSTP1 ) and
glutathione S - transferase m1 (
GSTM1 ) genotypes . -
pubmed
We examined the associations of
EPHX1 Tyr113His and His139Arg genotypes and diplotypes with
asthma and
wheezing outcomes under different ambient
NO2 exposures . -
pubmed
RESULTS : Children with the
EPHX1 Arg /
His or
Arg /
Arg genotypes at codon 139 were significantly associated with increased risks of lifetime
asthma ( adjusted OR [ aOR ] = 1.3 ; 95 % CI , 1.1 - 1.7 ; and aOR = 1.5 ; 95 % CI , 1.1 - 2.1 , respectively ) . -
pubmed
The
EPHX1 diplotypes showed significant associations with lifetime
asthma ( global P value = .01 ) and early - onset
asthma ( global P value = .01 ) . -
pubmed
CONCLUSIONS : Children with high
EPHX1 activity may have increase risk of
asthma and
wheezing outcomes , and can be mediated through airway oxidative stress generation . -
pubmed
Endothelial cell - specific deficiency of
Ang II type 1a receptors attenuates
Ang II - induced ascending
aortic aneurysms in
LDL receptor-/-
mice . -
pubmed
RATIONALE :
Human studies and
mouse models have provided evidence for
angiotensin II (
Ang II)-based mechanisms as an underlying cause of
aneurysms localized to the ascending aorta . -
pubmed
OBJECTIVE : The aim of this study was to define the role of
angiotensin II type 1a (
AT ( 1a ) ) receptors and their cellular location in
Ang II - induced
ascending aortic aneurysms (
AAs ) . -
pubmed
CONCLUSIONS :
Ang II infusion promotes
aneurysms in the ascending aorta via stimulation of
AT ( 1a ) receptors that are expressed on endothelial cells . -
pubmed
RANKL expression is related to treatment outcome of
patients with localized , high - grade
osteosarcoma . -
pubmed
BACKGROUND : The
receptor activator of nuclear factor kappaB ligand (
RANKL /
TNFSF11 ) is expressed in metastatic
bone cancer cells and has been suggested to play a key role in cell migration and metastatic behavior . -
pubmed
We determined whether
RANKL expression is correlated to clinical behavior of localized , high - grade
osteosarcoma . -
pubmed
RANKL expression and
RANKL scores were not related to age , sex ,
tumor location ,
tumor volume , or pathologic subtype . -
pubmed
CONCLUSIONS : The
RANKL -
RANK -
OPG axis might be a promising target for the treatment of
osteosarcoma , but further studies are needed to verify our data in a larger cohort . -
pubmed
The effects of
DISC1 risk variants on brain activation in controls , patients with
bipolar disorder and patients with
schizophrenia . -
pubmed
Three risk variants ( rs1538979 , rs821577 , and rs821633 ) in the
Disrupted - in - Schizophrenia-1 (
DISC1 ) gene have previously been associated with both
schizophrenia and
bipolar disorder in a recent collaborative analysis of European cohorts . -
pubmed
These findings may provide a better understanding of the neural effects of
DISC1 variants and on the pathophysiology of
schizophrenia and
bipolar disorder . -
pubmed
In the present study , we showed that
MAP1S levels immediately become elevated in response to
diethylnitrosamine - induced or genome instability - driven metabolic stress in a
murine model of
hepatocarcinoma . -
pubmed
We , therefore , conclude that an increase in
MAP1S levels triggers autophagy to suppress genome instability such that both the incidence of
diethylnitrosamine - induced
hepatocarcinogenesis and malignant progression are suppressed . -
pubmed
IPA - ranked signaling networks identified altered
p21 ,
EF1alpha ,
Akt ,
MAPK , and
NF - kappaB signaling networks promoting
genetic disorder , altered cell cycle ,
cancer and changes in nucleic acid and energy metabolism . -
pubmed
In
Drosophila melanogaster , mutations in the gene drop - dead (
drd ) result in early
adult lethality , with
flies dying within 2 weeks of eclosion . -
pubmed
Lipid peroxidation and
spectrin of RBC membrane in
hydroxyurea treated Ebeta
thalassaemia . -
pubmed
There was no change in PCV ,
Hb and
spectrin content of RBC membrane after HU therapy for 90 days in Ebeta
thalassaemia . -
pubmed
T - plastin is expressed in epithelial and mesenchymal cells of solid tissues , whereas
L - plastin is expressed in mobile cells such as hemopoietic cell lineages and
cancer cells . -
pubmed
Expression and clinical significance of
osteopontin in
calcified breast tissue . -
pubmed
In our study , we used semi - quantitative RT - PCR of
osteopontin in
calcification tissue of breast to detect
breast cancer metastasis . -
pubmed
The obtained data indicate that the expression of
osteopontin is related to
calcification tissue of breast , and possibly with the incidence of
breast cancer . -
pubmed
The expression strength of
OPN by RT - PCR detection was related to the degree of malignancy of
breast lesions , suggesting a close relationship between
OPN and
breast calcification tissue . -
pubmed
The results revealed that expression of
OPN mRNA is related to
calcification of breast cancer tissue and to the development of
breast cancer . -
pubmed
Determination of
OPN mRNA expression can be expected to be a guide to clinical therapy and prediction of the prognosis of
breast cancer patients . -
pubmed
The
BCAAs are particularly responsive to the inhibitory
insulin action on
amino acid release by skeletal muscle and their metabolism is profoundly altered in
insulin resistant conditions and/or
insulin deficiency . -
pubmed
A repeated - measures ANOVA ( group factor : treatment group and control group ; time factor : initial visit , 1.5 , 3 , and 6 months ) was used to analyze the probing depth ( PD ) , CAL ,
bleeding on probing ( BOP ) , high - sensitivity
C - reactive protein (
hsCRP ) ,
glycated hemoglobin (
HbA1c ) , and fasting plasma
glucose . -
pubmed
PURPOSE : To determine the functional discrepancy between the two liver lobes using
technetium 99 m (
( 99m ) Tc )
diethylenetriamine - pentaacetic acid -
galactosyl human serum albumin (
GSA diethylenetriamine - pentaacetic acid - galactosyl
human serum albumin ) single photon emission computed tomography ( SPECT)/computed tomography ( CT ) fusion imaging following preoperative biliary drainage and portal vein embolization ( PVE portal vein embolization ) in
patients with
jaundice who have
bile duct cancer ( BDC
bile duct cancer ) . -
pubmed
Preoperative
( 99m ) Tc - GSA diethylenetriamine - pentaacetic acid -
galactosyl human serum albumin SPECT / CT fusion images from 32
patients with extrahepatic BDC
bile duct cancer were retrospectively reviewed . -
pubmed
While stimulation of
formyl peptide receptors (
FPRs ) on the surface of
human neutrophils induces several immune responses , under conditions of continuous activation of the receptor by agonists such as
formyl - Met - Leu - Phe - OH (
fMLP ) , neutrophil - dependent
tissue damage ensues . -
pubmed
Using material from cohorts of genetically diagnosed
Ewing sarcoma with
EWSR1 chromosomal translocations , confocal images of tissue microarrays were segmented with level sets and watershed algorithms . -
pubmed
A prognostic classifier for
Ewing sarcoma with low cross - validation error rates ( 0.36 ) was comprised of multiple features , including the
Ki67 proliferative marker and a sub - population of cells with low cytoplasmic / nuclear ratio of
CD99 . -
pubmed
We performed additional testing in two genomic regions (
P2RX4 /
P2RX7 and
P2RY1 ) in a cohort from the Prevalence , Prediction , and Prevention of
Diabetes in Botnia ( n = 3504 ) , which includes more refined measures of
glucose homeostasis . -
pubmed
In the Prevalence , Prediction , and Prevention of
Diabetes in Botnia study , the minor allele in the missense functional variant rs1718119 ( A348 T ) in
P2RX7 was associated with increased
insulin sensitivity and secretion , consistent with its known effect on increased pore function . -
pubmed
Both male and female
P2x7 - C57
mice demonstrated
impaired glucose tolerance compared with matched P2x7 - 129
mice . -
pubmed
CONCLUSIONS : We show association of the purinergic signaling pathway in general and hypofunctioning
P2X7 variants in particular with
impaired glucose homeostasis in both
mice and
humans . -
pubmed
Human leukocyte antigen - DRB1 polymorphism in childhood
acute lymphoblastic leukemia . -
pubmed
Similar to
autoimmune diseases , there are clear associations between resistance or susceptibility to
cancer and the classic
human leukocyte antigen (
HLA ) profile of an individual . -
pubmed
The present study aimed to determine the association between the
HLA - DRB1 genotype and susceptibility to
ALL in children and to assess the prognostic value of
HLA - DRB1 alleles in these patients . -
pubmed
In conclusion , the
HLA - DRB1 * 04 allele appears to be a female - specific susceptibility factor for the acquisition of childhood
ALL and it may affect the age of onset of
ALL . -
pubmed
In addition , the
HLA - DRB1 * 11 allele may be of prognostic significance in childhood
ALL . -
pubmed
Laboratory data revealed a normal cell blood count and
beta hcg levels of 8047 IU / L. Because of continuing
abdominal pain and a diagnosis of
ectopic pregnancy a diagnostic laparoscopy was performed , which showed
hemoperitoneum . -
pubmed
An alternative pathway involves the leukocyte
heme protein
myeloperoxidase , which catalyzes the oxidation of
thiocyanate in the presence of
hydrogen peroxide , producing
isocyanate at
inflammation sites . -
pubmed
Recently , it has been shown that carbamylated low - density lipoprotein (
LDL ) induces
endothelial dysfunction via lectin - like - oxidized
LDL receptor-1 activation and increased reactive
oxygen species production , leading to
endothelial nitric oxide synthase uncoupling . -
pubmed
MATERIALS / METHODS : Six
Lewis rats received
interphotoreceptor retinoid - binding protein (
IRBP ) emulsion to induce
EAU . -
pubmed
We compared the preventive effects of
fosaprepitant , a
neurokinin-1 ( NK1 ) receptor antagonist , with those of
ondansetron on
PONV in
patients who underwent lower limb surgery with postoperative epidural opioid administration . -
pubmed
IGF-1 Levels are Inversely Associated With
Metabolic Syndrome in
Obstructive Sleep Apnea . -
pubmed
STUDY OBJECTIVES : This study examined
insulin - like growth factor-1 ( IGF-1 ) production and its association with the
metabolic syndrome (
MS ) in men with
obstructive sleep apnea (
OSA ) . -
pubmed
RESULTS :
IGF-1 level in the moderate - severe
OSA group was lower than in the no - OSA group ( 156.8 + - 54.3 mug / L versus 225.5 + - 80.5 mug / L ; p = 0.013 ) . -
pubmed
Furthermore , in the lowest tertile of
IGF-1 value , 66.7 % of
patients were affected by
MS ( p = 0.049 ) . -
pubmed
CONCLUSION : The occurrence of
OSA is associated with a reduction in
IGF-1 levels . -
pubmed
The best clinical performance to discriminate CC from
cervical intraepithelial neoplasia 2 to 3 was the one for the combination of anti -
E4 and/or anti -
E7 antibodies , which displayed high sensitivity ( 93.3 % ) and moderate specificity ( 64.1 % ) , followed by anti -
E4 and anti -
E7 antibodies ( 73.3 % and 80 % ; 89.6 % and 66 % , respectively ) . -
pubmed
In addition , the sensitivity of anti -
E4 and/or
anti - E7 antibodies is high at any time of sexual activity ( TSA ) , which suggests they can be biomarkers for the early detection of
CC . -
pubmed
In
Alzheimer ' s disease , soluble
Abeta oligomers are believed to play important roles in the disease pathogenesis , and their levels correlate with
cognitive impairment . -
pubmed
Independent risk factors for survival were administration of chemotherapy with the intention to induce remission , social class 1 and 2 ,
hepatomegaly , absence of
splenomegaly , lower
LDH , lower PB blast count , higher
haemoglobin , female sex and WHO performance status 0 - 2 . -
pubmed
CONCLUSIONS : We replicated and refined earlier findings of
impaired glucose metabolism and
nigrostriatal degeneration in
CBS , highlighting asymmetric cortical and subcortical hypometabolism , symmetrically reduced metabolism in the thalamus , and only a slightly asymmetric reduction in DAT , while
D2 / 3 receptors seem to be mainly preserved . -
pubmed
BACKGROUND : Aberrant activation of the
Hedgehog (
Hh ) pathway is a key driver in the pathogenesis of
basal cell carcinomas (
BCCs ) , including
patients with
BCC nevus syndrome (
BCCNS ) . -
pubmed
The microRNA miR-33a suppresses
IL-6 - induced
tumor progression by binding
Twist in
gallbladder cancer . -
pubmed
Cytokine is a key molecular link between chronic
inflammation and
gallbladder cancer (
GBC ) progression . -
pubmed
The potential mechanism of
cytokine - associated modulation of microRNAs ( miRNAs ) expression in
GBC progression is not fully understood . -
pubmed
In this study , we investigated the biological effects and prognostic significance of
interleukin-6 (
IL-6 ) -induced miRNAs in the development of
GBC . -
pubmed
We identify that inflammatory cytokine ,
IL-6 promotes proliferation , migration , invasion and epithelial - mesenchymal transition ( EMT ) of
GBC both in vitro and in vivo . -
pubmed
Among all the changed miRNAs in miRNA profiling , miR-33a expression was significantly decreased in
IL-6 treated
GBC cell lines , as well as in
GBC tissues compared with case - matched
normal tissues and
cholecystitis tissues . -
pubmed
In turn , miR-33a suppresses
IL-6 - induced
tumor metastasis by directly binding
Twist which was identified as an EMT marker . -
pubmed
Phosphatase and tensin homolog deleted on chromosome ten (
PTEN ) is a tumor suppressor and a therapeutic target for the
metabolic syndrome . -
pubmed
Prospective identification of resistance mechanisms to
HSP90 inhibition in
KRAS mutant
cancer cells . -
pubmed
To prospectively identify mechanisms through which
HSP90 - dependent
cancer cells evade pharmacologic
HSP90 blockade , we generated multiple mutant
KRAS - driven
cancer cell lines with acquired resistance to the
purine - scaffold
HSP90 inhibitor
PU - H71 . -
pubmed
The
EGR2 targets
LAG-3 and
4 - 1BB describe and regulate dysfunctional antigen - specific CD8 + T cells in the
tumor microenvironment . -
pubmed
Administration of anti -
LAG-3 plus
anti-4 - 1BB mAbs was therapeutic against
tumors in vivo , which correlated with phenotypic normalization . -
pubmed
Our results indicate that coexpression of
LAG-3 and
4 - 1BB characterize dysfunctional T cells within
tumors , and that targeting these receptors has therapeutic utility . -
pubmed
Fascin Is Associated With Aggressive Behavior and Poor Outcome in
Uterine Carcinosarcoma . -
pubmed
It is associated with poor outcomes in
human carcinoma , especially in
estrogen receptor ( ER )- negative tumors arising in organs normally expressing
ER . -
pubmed
We sought to evaluate
fascin expression in
UCS and its relationship to
ER status , clinicopathologic indicators of
tumor aggressiveness , and survival outcomes . -
pubmed
METHOD : Forty - four surgically staged cases of
UCS were immunohistochemically evaluated for
fascin and
estrogen receptor - alpha expression and correlated with clinicopathologic parameters derived from electronic medical records and pathology reports . -
pubmed
Increased expression was associated with
extrapelvic disease ( P = 0.028 ) , higher stage ( P = 0.021 ) , larger
tumor size ( P = 0.032 ) , shorter progression - free interval ( P = 0.035 ) , and reduced
estrogen receptor - alpha expression ( P = 0.04 ) . -
pubmed
CONCLUSION :
Fascin is aberrantly expressed in both elements of
UCS and is associated with
aggressive behavior and worse outcome . -
pubmed
Signaling via the
transient receptor potential ( TRP ) ion channel C6 plays a pivotal role in
hereditary and sporadic glomerular kidney disease . -
pubmed
Several studies have identified gain - of - function mutations of
TRPC6 and report induced expression and enhanced channel activity of
TRPC6 in association with
glomerular diseases . -
pubmed
A 37 - year - old Japanese
woman suffered from
orthostatic hypotension was diagnosed with
multiple myeloma (
IgG kappa type ) , and a serological examination revealed the presence of anti -
ganglionic nicotinic acetylcholine receptor ( anti -
gAChR ) antibodies . -
pubmed
She was treated for
multiple myeloma , as a result , the autonomic disturbance improved and her anti -
gAChR antibody titer decreased to undetectable levels , despite the fact that she only achieved a partial remission of
multiple myeloma . -
pubmed
SYSTEMIC BETA - BLOCKERS AND RISK OF PROGRESSION TO NEOVASCULAR AGE - RELATED
MACULAR DEGENERATION . -
pubmed
Patients with
nonexudative AMD who initiated ( index date ) BB , a
calcium channel blocker ( CCB ) , an
angiotensin - converting enzyme /
angiotensin receptor blocker , or a diuretic . -
pubmed
Patients on BB versus
angiotensin - converting enzyme /
angiotensin receptor blocker at all time points and BB versus
CCB and diuretics at 365 days did not have a significantly lower association with
nAMD ( HR : 0.73 - 0.85 ; P & gt ; 0.06 for all comparisons ) . -
pubmed
Transforming growth factor beta superfamily regulation of adipose tissue biology in
obesity . -
pubmed
This review focuses on the recent development in understanding the role of
TGFbeta superfamily in the regulation of white , brite and brown adipocyte differentiation , adipose tissue
fibrosis , and adipocyte metabolic and endocrine functions . -
pubmed
TGFbeta family and their antagonists are produced locally within adipose tissues and their expression levels are altered in
obesity . -
pubmed
DR4 mediates the progression , invasion , metastasis and survival of
colorectal cancer through the
Sp1 /
NF1 switch axis on genomic locus . -
pubmed
The single nucleotide polymorphism ( SNP ) , -397 G & gt ; T ( rs13278062 ) polymorphism , in the promoter of
Death Receptor 4 (
DR4 ) had been reported to be associated with a significantly increased risk for
bladder cancer . -
pubmed
In this study , we performed a case - control study in 1,078
colorectal cancer patients and 1,175 matched
healthy controls to evaluate the association of the potential functional genetic variants in
DR4 with risk and survival of
colorectal cancer . -
pubmed
Immunohistochemistry , western blot , and qPCR corroborated that the rs13278062 GT / TT genotypes increased the expression of
DR4 protein in
colorectal cancer tissues and cells . -
pubmed
In conclusion , these findings indicate that
DR4 mediated progression , invasion , metastasis and survival of
colorectal cancer via the
Sp1 /
NF1 switch axis on genomics locus . -
pubmed
Elucidation of the
FKBP25 - 60S Ribosomal Protein L7a Stress Response Signaling During
Ischemic Injury . -
pubmed
Coimmunoprecipitation and FRET data indicated that
FKBP25 translocated into the nucleus , in which it interacted with
60S ribosomal protein L7a , while overexpression
FKBP25 protect endothelial cells against
OGD injury . -
pubmed
CONCLUSION : Our findings reveal that the nuclear import of
FKBP25 and binding with
60S ribosomal protein L7a are protective stress responses to
ischemia / nitrosaive
stress injury . -
pubmed
Infection increases
insulin resistance and subsequently increases
insulin needs . -
pubmed
We are reporting a case of a
patient with
T1DM and severe
infection who has reduced
insulin needs after starting
micafungin therapy . -
pubmed
She had uncontrolled
diabetes with a glycosylated
hemoglobin of 13.4 % ( 18.8 mM ) on admission . -
pubmed
Her
insulin requirements progressively increased as a result of worsening
infection , continuous tube feeds , and multiple debridement surgeries . -
pubmed
Results : This is a report of decreased
insulin requirements in a
patient with
T1DM correlating with
micafungin administration . -
pubmed
Conclusion : We hypothesize that
micafungin may inhibit
SGLT-1 function and decrease
insulin requirements in
patient with
T1DM . -
pubmed
Phase 1b Study of
Trebananib Plus
Paclitaxel and Trastuzumab in
Patients With
HER2 - Positive Locally Recurrent or Metastatic
Breast Cancer . -
pubmed
Trebananib plus trastuzumab and
paclitaxel was evaluated in
human epidermal growth factor receptor 2 - positive
breast cancer in an open - label phase 1b clinical study . -
pubmed
PATIENTS AND METHODS :
Women with
human epidermal growth factor receptor 2 - positive
breast cancer received weekly
paclitaxel ( 80 mg / m2 ) , trastuzumab ( 8 mg / m2 then 6 mg / kg every 3 weeks ) , and intravenous
trebananib ( 10 mg / kg or 30 mg / kg weekly ) beginning week 2 . -
pubmed
RESULTS : Forty
women were enrolled ; 2 experienced dose - limiting
toxicities ( grade 3
ocular transient ischemic attack [ 10 mg / kg cohort ] and grade 3 elevation in
gamma - glutamyl transferase [ 30 mg / kg cohort ] ) . -
pubmed
Complete pathological response following neoadjuvant FOLFOX chemotherapy in
BRCA2 - mutant locally advanced
rectal cancer : a case report . -
pubmed
The next - generation sequencing analysis revealed the presence of
breast cancer gene 2 (
BRCA2 ) somatic mutation and an increased somatic mutational load without
microsatellite instability ( MSI ) . -
pubmed
Conclusion : Considering the previous improvements of physical and compositional properties of
collagen scaffolds and recent manufacturing developments of structural polymer , it is concluded that hybrid strategy is a promising approach to advance further
collagen - based scaffolds in
CTE . -
pubmed
We discovered that only
carbon nanoparticle -
Pb2 + adducts , not other pollutants or adducts , induced
inflammation in
human bronchial cells by suppressing the expression of a novel long noncoding RNA
lnc - PCK1 - 2:1 , while
lnc - PCK1 - 2:1 routinely plays a regulatory role in inhibiting
inflammation . -
pubmed
There are increasing data showing that
cervical neuroendocrine carcinomas may be associated with the
human papillomavirus (
HPV ) , especially
HPV18 , and most will stain positive for
p16 . -
pubmed
Although there are no commonly associated mutations ,
PIK3CA ,
KRAS , and
TP53 are the most frequently found mutations in neuroendocrine
tumors . -
pubmed
Mid - regional
proadrenomedullin (
MR - proADM ) , shows promising results as outcome predictor in
patients with
sepsis . -
pubmed
Plasma total
fibroblast growth factor 23 levels are associated with
acute kidney injury and mortality in
children with
acute respiratory distress syndrome . -
pubmed
Pre - clinical data suggest that
fibroblast growth factor 23 (
FGF23 ) may contribute to pulmonary pathology , and
FGF23 is associated with mortality and morbidity , including
acute kidney injury (
AKI ) , in non -
ARDS cohorts . -
pubmed
Here , we assess whether
FGF23 is associated with
AKI and/or mortality in a cohort of 161 pediatric
ARDS patients . -
pubmed
Plasma total ( intact + C - terminal )
FGF23 and intact
FGF23 concentrations were measured within 24 hours of
ARDS diagnosis ( Day 1 ) , and associations with Day 3
AKI and 60 - day mortality were evaluated . -
pubmed
In unadjusted models , higher Day 1 total
FGF23 was associated with Day 3
AKI ( odds ratio ( OR ) 2.22 [ 95 % confidence interval ( CI ) 1.62 , 3.03 ] , p<0.001 ) , but Day 1 intact
FGF23 was not . -
pubmed
In a model adjusted for demographics and disease severity , total
FGF23 remained associated with
AKI ( OR 1.52 [ 95 % CI 1.02 , 2.26 ] , p = 0.039 ) . -
pubmed
In a subgroup analysis of patients with Day 1 plasma
IL-6 concentrations available ,
inflammation partially mediated the association between total
FGF23 and
AKI . -
pubmed
Our data suggest both
inflammation - dependent and
inflammation - independent associations between total
FGF23 and clinical outcomes in pediatric
ARDS patients . -
pubmed
SMA /
CORM-2 exerted both in vitro and in vivo anti - proliferation and anti - metastatic effects , which may yield a novel therapeutic strategy for
CRC . -
pubmed
EXPERIMENTAL DESIGN : Two syngeneic models of
oral cavity carcinoma with defined
T cell antigens were treated with
PD-1 mAb before or after surgical resection of primary
tumors , and antigen - specific T cell responses were explored with functional and in vivochallenge assays . -
pubmed
Using
tumors lacking the immunodominant antigen as a model of antigen escape , neoadjuvant
PD-1 immune checkpoint blockade induced effector T cell immunity against
tumor cells lacking immunodominant but retaining subdominant antigen . -
pubmed
When combined with complete surgical excision , neoadjuvant
PD-1 immune checkpoint blockade led to formation of immunologic memory capable of preventing engraftment of
tumors lacking the immunodominant but retaining subdominant antigen . -
pubmed
CONCLUSIONS : Together , these results implicate
PD-1 expression by T cells in the mechanism of functional immunodominance among independent
T cell clones within a progressing
tumor , and support the use of neoadjuvant
PD-1 immune checkpoint blockade in
patients with surgically resectable
carcinomas . -
pubmed
Tau deposition in young
adults with drug - resistant
focal epilepsy . -
pubmed
All
formalin - fixed , paraffin - embedded blocks from the surgical specimens from each subject were sectioned and stained with
hematoxylin and eosin and antibodies to
tau ( Thermo Fisher Scientific Clone AT8 ) , and examined blindly for tau pathology , including lesions characteristic of
CTE . -
pubmed
Although none of the
patients had pathological findings characteristic of
CTE , 23
patients ( 38 % ) demonstrated
tau - immunoreactive lesions , including neurites , neurofibrillary pretangles , neurofibrillary tangles , subpial tau , and/or glial tau . -
pubmed
SIGNIFICANCE :
Tau - immunoreactive lesions were found in 38 % of 60
patients who underwent a focal cortical resection for drug - resistant
focal epilepsy . -
pubmed
Knockdown of
NSD2 Suppresses
Renal Cell Carcinoma Metastasis by Inhibiting Epithelial - Mesenchymal Transition . -
pubmed
Nuclear receptor suppressor of variegation , enhancer of zeste , and
trithorax ( SET ) domain - containing 2 (
NSD2 ) , belonging to NSD protein family , functions as an oncogene in the pathogenesis of multiple
cancers . -
pubmed
Methods : GEO database was used to analyze the expression of
NSD2 mRNA in
renal cancer . -
pubmed
Furthermore ,
NSD2 protein level in
clear cell RCC (
ccRCC ) tissues was detected by immunohistochemistry ( IHC ) . -
pubmed
The biological role and molecular mechanism of
NSD2 in
RCC metastasis were investigated via a series of functional experiments . -
pubmed
Results :
NSD2 mRNA was massively amplified in several types of
renal cancer , especially in metastatic
ccRCC . -
pubmed
The expression level of
NSD2 protein was elevated in
ccRCC tissues , but not correlated with pathological grading . -
pubmed
The migratory and invasive properties were significantly repressed in
NSD2 - silenced
RCC cells , concurrent with an increase of
E - cadherin expression and a decrease of
N - cadherin and
Vimentin expression . -
pubmed
Conclusion : Down - regulation of
NSD2 could potently suppress cell migration and invasion through inhibiting epithelial - mesenchymal transition ( EMT ) , indicating that
NSD2 may be a potential therapeutic target for metastatic
RCC . -
pubmed
miR-21 may Act as a Potential Mediator Between
Inflammation and Abnormal Bone Formation in
Ankylosing Spondylitis Based on
TNF - alpha Concentration - Dependent Manner Through the
JAK2 /
STAT3 Pathway . -
pubmed
Objective : To explore the role of microRNA ( miR-21 ) in new bone formation in
ankylosing spondylitis (
AS ) as mediated by different concentration of
tumor necrosis factor - alpha (
TNF - alpha ) . -
pubmed
Relative expressions of
p - STAT3 ,
Nuclear STAT3 , cytoplasm
STAT3 ,
Runx2 ,
BMP2 ,
osteopontin ,
osteocalcin , and
LC3B in
AS fibroblasts were measured after exposure to different concentrations of
TNF - alpha . -
pubmed
We report two rare cases of late - onset
brain edema after craniotomy for clipping or coating of unruptured
intracranial aneurysms , possibly due to an
allergic reaction to topically applied
fibrin glue or gelatin sponge used for arachnoid plasty to cover the opened sylvian cistern . -
pubmed
Five to six weeks after surgery without complications , MR images showed an extensive T2 prolongated region in the white matter around the operative field , indicative of
vasogenic edema , with mass effect and meningeal enhancement around the sylvian fissure that had been covered with gelatin sponge and sprayed
fibrin glue . -
pubmed
Delayed
brain edema may occur around the arachnoid plasty area despite an uneventful chronic postoperative period , which could be due to an
allergic reaction to locally administered
fibrin glue or gelatin sponge . -
pubmed
Thus , the application of arachnoid plasty using
fibrin glue and gelatin sponge in
patients with a predisposition to
allergies needs to be carefully considered . -
pubmed
A Novel Role of
Growth Differentiation Factor ( GDF )- 15 in Overlap with Sedentary Lifestyle and Cognitive Risk in
COPD . -
pubmed
Physical activity ( PA ) , cognitive function ( Japanese version of the Montreal Cognitive Assessment : MOCA - J ) , and the serum
GDF-15 levels were assessed in healthy
subjects ( n = 14 ) ,
asthmatics ( n = 22 ) , and
COPD patients ( n = 28 ) . -
pubmed
Compared to healthy subjects and
asthmatics ,
COPD patients showed the highest serum
GDF-15 levels and had a significantly higher proportion of subjects with
MCR ( both sedentary lifestyle ( EX < 1.5 ) and cognitive risk ( MoCA - J < = 25 ) ) . -
pubmed
Also , we found that serum
GDF-15 has a screening potential ( 100 % sensitivity ) greater than aging ( 67 % sensitivity ) for detecting
MCR in
COPD patients . -
pubmed
Sortase - Mediated Site - Specific Modification of
Interleukin-2 for the Generation of a
Tumor - Targeting
Acetazolamide -
Cytokine Conjugate . -
pubmed
Here , we describe the preparation and in vivo characterization of the first small molecule -
cytokine conjugate targeting
carbonic anhydrase IX (
CAIX ) , a marker of
renal cell carcinoma and
hypoxia . -
pubmed
The in vivo targeting of structures expressing
carbonic anhydrase IX was assessed by biodistribution experiments in
tumor - bearing
mice . -
pubmed
Optimization of manufacturability and
tumor - targeting performance of
acetazolamide -
cytokine products will be required in order to enable industrial applications . -
pubmed
OGA Inhibition Alters Energetics and Nutrient Sensing in
Alzheimer ' s Disease Cytoplasmic Hybrids . -
pubmed
METHODS : We induced increased
O - GlcNAc by treating
AD and control cybrid cell lines with
Thiamet G (
TMG ) , an inhibitor of the
O - GlcNAcase enzyme that mediates removal of the nutrient - dependent
O - GlcNAc modification . -
pubmed
At baseline ,
AD cybrid cell line mitochondria showed partial activation of several proteins that help maintain bioenergetic homeostasis such as
AMP - Regulated Kinase suggesting that
AD mitochondria initiate a state of nutrient stress promoting energetic compensation ; however , this compensation reduces the capacity of cells to respond to additional nutrient - related stresses such as
TMG treatment . -
pubmed
In conditions in which
anti - PD-1 , alone or in combination with anti -
CTLA-4 , failed to reduce
tumor growth in
mice receiving a standard diet , KD or oral supplementation of
3HB reestablished therapeutic responses . -
pubmed
We also found that
tomatidine significantly regulated serum total
cholesterol , fasting blood
glucose , low - density lipoprotein , and
triglyceride levels , but the serum high - density lipoprotein and
adiponectin concentrations were higher than in the HFD - fed
obese mice . -
pubmed
These findings suggest that
tomatidine potentially ameliorates
obesity and acts against
hepatic steatosis by regulating lipogenesis and the
sirt1 /
AMPK pathway . -
pubmed
[ Significance of stimulated serum
insulin analysis in
diabetes ,
organic hyperinsulinism (
islet cell adenoma ) and in the so - called "
non - hypoglycemic syndrome " ] . -
pubmed
Inhibition of liver
HMG - CoTA reductase does not appear to account for the hypocholesterolemic effect , and activation of mitochondrial
alpha - glycerophosphate dehydrogenase does not explain the
hypotriglyceridemic action . -
pubmed
Reduction of
very low density lipoprotein (
VLDL ) and high density lipoprotein (
HDL ) levels in
rats with
sucrose - induced
hyperlipidemia and normalization of the altered
apolipoprotein profiles are in accord with the effects of
halofenate on plasma
triglyceride and
cholesterol levels . -
pubmed
The reduced
insulin - to - glucagon ratio observed in Zucker obese
hyperlipemic rats is also consistent with
halofenat 's
hypotriglyceridemic activity . -
pubmed
Polycythaemia and
erythropoietin producing
uterine fibromyoma . -
pubmed
Deletion of the Hunter gene and both
DXS466 and
DXS304 in a patient with
mucopolysaccharidosis type II . -
pubmed
Hunter syndrome is an
X - linked mucopolysaccharidosis due to
deficiency of the lysosomal enzyme iduronate-2 - sulfatase (
IDS ) . -
pubmed
A cDNA clone containing the entire coding region of the
human IDS gene , mapped in Xq28 , has been used as molecular probe to study a patient with
Hunter syndrome . -
pubmed
A submicroscopic deletion has been detected that spans the
IDS gene as well as
DXS466 and
DXS304 , 2 loci mapped probably not more than 900 kb from the
IDS locus . -
pubmed
Although
diabetes appears to be an independent cardiovascular risk factor , increases in total and
LDL - cholesterol together with a decrease of
HDL - cholesterol are more pronounced in
diabetics with
cardiovascular disease . -
pubmed
When atherogenic indices ( such as the relationship between total
cholesterol and
HDL -
cholesterol or the
Apo A1 /
apo B quotient ) are used , 20 to 30 % of an
IDDM population considered to be in clinically acceptable control have to be considered pathological . -
pubmed
Enterotoxin and
toxic shock syndrome toxin - one production by staphylococci isolated from
mastitis in
sheep . -
pubmed
The lack of effect of
PHV infusion on blood pressure , despite
tachycardia and marked cutaneous vasodilatation , implies that PHV has a different effect on the resistance vessels from that of other peptides such as
VIP . -
pubmed
Receptors ,
growth factors and
steroid insensitivity of
tumours . -
pubmed
Insulin - mediated
glucose metabolism ( euglycemic
insulin clamp at plasma
insulin concentration of 100 microU / mL ) and
glucose - stimulated
insulin secretion (
hyperglycemic clamp ) were examined in 42
obese subjects ( ideal body weight [ IBW ] , 158 + /- 4 % ) with normal
glucose tolerance and in 36 normal weight ( IBW , 102 % + /- 1 % ) age - matched controls . -
pubmed
In 10
obese and eight control subjects ,
insulin was infused at six rates to increase plasma
insulin concentration by approximately 10 , 20 , 40 , 80 , 2,000 , and 20,000 microU / mL. -
pubmed
Throughout the physiologic range of plasma
insulin concentrations , both the increase in total body
glucose uptake and the suppression of hepatic
glucose production ( HGP ) were significantly impaired in the
obese group ( P less than .001 to .01 ) . -
pubmed
At the two highest plasma
insulin concentrations , inhibition of HGP and the stimulation of
glucose disposal were similar in both the
obese and control groups . -
pubmed
Insulin secretion during the
hyperglycemic ( + /- 125 mg / dL ) clamp was twofold greater in
obese subjects than in controls ( P less than .01 ) and was inversely related to the rate of
glucose uptake during the
insulin clamp ( r = -.438 , P less than .05 ) , but was still unable to normalize
glucose disposal ( P less than .05 ) . -
pubmed
In conclusion , our results indicate that
insulin resistance is a common accompaniment of
obesity and can be overcome at supraphysiological
insulin concentrations . -
pubmed
Especially
diabetic patients might be expected to benefit from this therapy , if given preferably as
beta 1 - selective blocker that impairs
carbohydrate and lipid metabolism in lesser extent . -
pubmed
A group of 117
mucinous cystomas were investigated by histochemical methods ( PB / KOH / PAS ; PAT / KOH / Bh / PAS ) , to demonstrate the presence of O - acetylated
sialomucin variants in goblet cells of intestinal type component . -
pubmed
Moreover , immunohistochemically , by means of anti -
chromogranin A monoclonal antibodies , endocrine cells were found in benign , borderline and
malignant mucinous cystomas of mixed type . -
pubmed
Decreased
NA + , K +- ATPase activity in erythrocyte membrane from
rheumatoid arthritis patients . -
pubmed
The activity of the plasma membrane
Na +/ K +- ATPase and cellular
sodium (
Nai ) and
potassium ( Ki ) content were analysed in RBCs from 15
rheumatoid arthritis (
RA ) and 30 reference subjects ( 11 healthy controls , 12
osteoarthritis and 7
gouty patients ) . -
pubmed
The
Na / K - ATPase activity was significantly lower in
RA patients than in both healthy controls and
patients with
osteoarthritis or
gout . -
pubmed
It is hypothesized that the decrease in the
Na +/ K +- ATPase activity in
RA may be the result of a defective expression of membrane proteins , which is probably related to the altered cell sensitivity observed . -
pubmed
Prognostic significance of serum
alpha 1 - acid glycoprotein in
patients with
glioblastoma multiforme : a preliminary communication . -
pubmed
The relationship between the levels of serum acute phase reactant proteins (
alpha 1 - acid glycoprotein ,
alpha 1 - antitrypsin ,
haptoglobin ) was investigated in
patients with
glioblastoma multiforme in relation to their prognosis . -
pubmed
It is suggested that serum
alpha 1 - acid glycoprotein profiles provide prognostic information in
patients with
glioblastoma multiforme . -
pubmed
Neurokinin - induced
salivation in the anesthetized
rat : a three receptor hypothesis . -
pubmed
blocked both
acetylcholine- and neurokinin B- , but not
substance P- or neurokinin A - induced
salivation . -
pubmed
, a putative
substance P antagonist , reduced responses to mammalian neurokinins but caused a 2 - fold potentiation of
acetylcholine - induced
salivation . -
pubmed
, a novel putative
neurokinin B antagonist , significantly reduced
substance P- and neurokinin B- but not
acetylcholine- or neurokinin A - induced
salivation . -
pubmed
Based on the differential effects of the three antagonists on neurokinin- and
acetylcholine - induced
salivation , we hypothesize the existence of three distinct
neurokinin receptors in
rat salivary gland , and suggest that
neurokinin B receptors reside presynaptically . -
pubmed
Microsomes prepared from
Ehrlich tumor cells were ineffective as inactivators of
MAIQ . -
pubmed
Low serum bioactive
luteinizing hormone in nonorganic
male impotence : possible relationship with altered
gonadotropin - releasing hormone pulsatility . -
pubmed
We determined the biological activity of
serum LH in 23
men , aged 25 - 50 yr , complaining of
nonorganic impotence of at least 1 - yr duration and 20 normal
men . -
pubmed
Stimulating and
differentiation factors for
human B lymphocytes in
systemic lupus erythematosus . -
pubmed
T cells from 18 untreated
SLE patients produced significantly more
B cell growth factor (
BCGF ) than did those from normal subjects . -
pubmed
The response to
BCGF of SAC - stimulated B lymphocytes from
SLE patients was higher than that of B lymphocytes from normal individuals . -
pubmed
Similarly preactivated B cells from five of seven
SLE patients also proliferated upon the addition of
interleukin 1 (
IL-1 ) whereas those of normal subjects did not . -
pubmed
Simultaneous addition of
IL-1 and
BCGF had a synergistic proliferative effect on B cells from two of seven
SLE patients but not on any of the controls . -
pubmed
Interleukin 2 (
IL-2 ) had no proliferative effect in either
SLE or normal B cells . -
pubmed
Supernatant fractions from T cells of seven of 10 patients with active
SLE and three of 10 with inactive
SLE induced more
IgG production by CESS cells than did those of normal subjects indicating a higher production of
B cell differentiation factor by
SLE T cells than by those of controls . -
pubmed
Our findings may explain the reported preactivation and predifferentiation of peripheral blood B cells from
SLE patients and give insight into the mechanisms leading to the production of
autoantibodies in this disease . -
pubmed
Phorbol myristate acetate (
PMA ) suppresses polarization and locomotion and alters
F - actin content of
Walker carcinosarcoma cells . -
pubmed
Changes in shape and chemokinesis of
Walker carcinosarcoma cells were associated with alterations in the relative amount and the topographical distribution of
F - actin as determined by
NBD - phallacidin binding . -
pubmed
We show here that
hyperkalaemia contributes markedly to the post - nephrectomy increase in adrenal
angiotensin II receptors , and that circulating
angiotensin II levels persist for an unexpectedly long period after nephrectomy , presumably due to tissue generation of the octapeptide . -
pubmed
The initial rate of
lecithin : cholesterol acyl transferase and serum concentration of lipids were determined in euthyroid ,
hypothyroid and
hyperthyroid subjects . -
pubmed
In rectal
tumor patients , particularly at stage IV , the level of
PHA - induced BRL and the total number of rosette - forming cells ( RFC ) were lower than in healthy donors . -
pubmed
[ RBE determinations of
tumours by
serum aldolase ? -
pubmed
The birefringent optical property of
collagen has enabled us to assess the
collagen architecture for brain arteries , which are prone to
spasm and
aneurysm formation . -
pubmed
Effects of
propranolol and
atenolol on immobilization stress - induced
hypertension and down - regulation of central
beta - adrenoceptors in
rats . -
pubmed
TCR / CD3 ligation of a TCR - transgenic T
lymphoma blocks its proliferation in vitro but does not affect its growth in vivo . -
pubmed
A backcrossed
mouse line was established homozygous for the autosomal recessive mutation scid (
severe combined immunodeficiency ) and carrying T cells which express transgenic ( tg )
T cell receptor ( TCR ) alpha and beta chains that mediate
H-2 class I ( Db)-restricted recognition of a male ( H - Y ) determinant ( TCR - tg SCID
mouse ) . -
pubmed
A
thymoma arose ' spontaneously ' in one of the
TCR - tg female SCID
mice and the
thymoma cells were adopted to factor - independent , in vitro growth in long - term tissue culture . -
pubmed
Patients with
aplastic anemia (
AA ) respond to immunosuppressive therapy , and several lines of laboratory evidence support a role for cell - mediated immunity in the pathogenesis of
marrow failure including expansion of cytotoxic T lymphocytes ( CTL ) in the blood of
AA patients , overexpression of inhibitors such as
IFN - gamma in the marrow of
AA patients , and suppression of hematopoietic cells by CTL in vitro . -
pubmed
Our study shows that percentages of
HLA - DR+
CD8 + lymphocytes and natural killer ( NK ) cells ,
CD56 + , were elevated in the marrow of
AA patients . -
pubmed
Monoclonal antibody against
CD11b / CD18 inhibits endotoxin - induced
uveitis . -
pubmed
PURPOSE : To examine the serial expression of
cell adhesion molecules in
C3H / HeN mice with endotoxin - induced
uveitis , and to study the effect of treatment with a monoclonal antibody against
Mac-1 on the development of endotoxin - induced
uveitis . -
pubmed
METHODS : Immunohistochemical staining was used to document the serial expression of
Mac-1 ,
intercellular adhesion molecule-1 (
ICAM-1 ) , and
lymphocyte function - associated antigen-1 (
LFA-1 ) in eyes of
C3H / HeN mice with endotoxin - induced
uveitis . -
pubmed
Treatment with
anti - MAC-1 antibody significantly inhibited the development of
ocular inflammation when compared with treatment with control
IgG ( P & lt ; 0.001 ) . -
pubmed
CONCLUSION :
Intercellular adhesion molecule-1 is expressed in the eye before clinical or histologic signs of
inflammation . -
pubmed
Furthermore , treatment with antibody against
Mac-1 significantly inhibits the development of endotoxin - induced
uveitis in
mice and suggests that anti -
Mac-1 antibody may be useful for treating
acute ocular inflammation . -
pubmed
Higher levels of urinary
met - haemoglobin were found in
dogs with naturally occurring
Babesia canis infection ( n = 6 ) than in control subjects ( n = 5 ) . -
pubmed
This was a significant finding in that
met - haemoglobin has been shown to be
nephrotoxic in the
dog , especially in the presence of
aciduria . -
pubmed
The present study was conducted to investigate the effect of
zinc deficiency on desaturation of
linoleic acid in
rats that were initially force - fed fat - free diets to stimulate activity of
desaturases . -
pubmed
Diffuse drainage , particularly involving the glans penis and corpus spongiosum , is greatly predictive of a poor or no response , reflecting the underlying cavernous smooth muscle
myopathy and
collagen degenerative alterations in these
patients with
end - organ failure . -
pubmed
Immunological mechanisms , including stimulation of brain microglia and elevation of various
inflammatory cytokines , have been implicated in the pathogenesis of
Alzheimer ' s disease , where accumulation of
beta - amyloid peptide (
A beta ) is one of its main pathological features . -
pubmed
Identification of the pathway by which
extracellular A beta activates the intracellular
PKC - dependent secretion of
TNF - alpha may help in developing new therapeutic strategies for
Alzheimer ' s disease . -
pubmed
Topical delivery of
tranilast (
N -( 3,4 - dimethoxycinnamoyl ) anthranic acid ) , an inhibitor of
collagen synthesis and a therapeutic drug for
keloid and
hypertrophic scar , was examined , in
rats , with
oleic acid alone or a combination of
oleic acid and
propylene glycol as penetration enhancer . -
pubmed
Somatic mutations of the
beta - catenin gene are frequent in
mouse and
human hepatocellular carcinomas . -
pubmed
The
Wnt - beta - catenin pathway is activated in
colon cancers and some
melanoma cell lines , but has not yet been investigated in
HCC . -
pubmed
We have examined the status of the
beta - catenin gene in different transgenic
mouse lines of
HCC obtained with the oncogenes
c - myc or
H - ras . -
pubmed
Fifty percent of the
hepatic tumors in these
transgenic mice had activating somatic mutations within the
beta - catenin gene similar to those found in
colon cancers and
melanomas . -
pubmed
Thus alterations in the
beta - catenin gene frequently are selected for during liver tumorigenesis and suggest that disregulation of the Wnt - beta - catenin pathway is a major event in the development of
HCC in
humans and
mice . -
pubmed
These results show that
adenosine potentiates
insulin- and contraction - stimulated
glucose transport in skeletal muscle by enhancing the increase in
GLUT4 at the cell surface and raise the possibility that decreased
adenosine production or action could play a causative role in
insulin resistance . -
pubmed
Genetic dissection of
Alzheimer ' s disease and related
dementias : amyloid and its relationship to
tau . -
pubmed
Recent data also suggests that dysfunction in the cytoskeletal protein
tau is on the pathway that leads to neurodegeneration and
dementia . -
pubmed
Tau is produced either indirectly , by
A beta 42 , or directly , in some forms of
frontotemporal dementia by mutations in
tau itself . -
pubmed
OBJECTIVE : To assess the variability of synovial histology , immunohistology , and
cytokine mRNA expression at different sites within the knee joints of
subjects with
rheumatoid arthritis receiving slow acting antirheumatic drugs . -
pubmed
HIV-2 antigen was detectable in peripheral blood mononuclear cell ( PBMC ) cocultures in all animals after 10 days of
HIV-2 infection ; a rapid decline in
CD4(+ ) PBMC ( & lt;350 / microliter ) was seen in five of six animals 21 days and 28 days after
infection . -
pubmed
Monoclonal antibody specific for
tissue factor pathway inhibitor - factor Xa complex : its characterization and application to plasmas from
patients with
disseminated intravascular coagulation and
pre - disseminated intravascular coagulation . -
pubmed
The normal range assessed from analyses of plasma from 30 normal healthy
volunteers was 17.7 - 66.7 with a mean of 35.5 + /- 11.7 pmol / l. In order to asses the clinical implication of
TFPI - Xa complex in the plasma of
patients with
thrombotic disorders , plasma concentrations were measured in 37
patients with
disseminated intravascular coagulation (
DIC ) caused by a variety of underlying diseases . -
pubmed
The
TFPI - Xa antigen levels were significantly higher in the
patients with
DIC ( 51.9 + /- 21.6 pmol / l ) and the 36
patients with pre - DIC ( 55.1 + /- 20.2 pmol / l ) than in the 137 non - DIC
patients ( 37.9 + /- 13.1 pmol / l ) . -
pubmed
In the
patients with
DIC or pre - DIC , there was no significant correlation between
TFPI - Xa complex and the elevated levels of
thrombin -
antithrombin complex ,
plasmin - alpha2 plasmin inhibitor complex , D - dimer , soluble
fibrin monomer , soluble
thrombomodulin or
tissue factor . -
pubmed
Utility of
nuclear matrix protein (
NMP22 ) in the detection of recurrent
bladder cancer . -
pubmed
This article examines the
Nuclear Matrix Protein (
NMP22 ) urine test for recurrent
bladder cancer detection . -
pubmed
Moreover ,
HDGF colocalizes with the
proliferating cell nuclear antigen (
PCNA ) in SMCs in
human atherosclerotic carotid arteries , suggesting that
HDGF helps regulate SMC growth during development and in response to
vascular injury . -
pubmed
Cytokine dysregulation in activated
cystic fibrosis (
CF ) peripheral lymphocytes . -
pubmed
Recent studies demonstrate in vivo and in vitro
cytokine dysregulation in
CF epithelial cells . -
pubmed
To see if these abnormalities may be generalized to other cells expressing
cystic fibrosis transmembrane conductance regulator (
CFTR ) but not directly exposed to local inflammation , we studied mRNA transcription , intracellular protein production and extracellular secretion of
IL-2 ,
IL-4 ,
IL-5 ,
IL-10 and
interferon - gamma (
IFN - gamma ) from freshly isolated blood mononuclear and CD4 + T cells from
CF patients and controls . -
pubmed
These findings extend defects described in respiratory epithelial cells to circulating immunoregulatory cells , suggesting a link between
CF genotype and
cytokine dysregulation . -
pubmed
Reduced
CD44 standard expression is associated with
tumour recurrence and unfavourable outcome in
differentiated thyroid carcinoma . -
pubmed
CD44 was detected with an antibody recognizing all forms of
CD44 (
CD44 standard ) and others specific for its v3 and v6 variant isoforms ; their prognostic value was evaluated in 213
patients with
differentiated thyroid carcinoma (
DTC ) . -
pubmed
The staining patterns of
CD44 standard ( s ) and
CD44v6 in
tumour tissue were quite similar , 176 cases ( 83 % ) being
highly positive for CD44s and 153 cases ( 72 % ) for
CD44v6 . -
pubmed
Only 18 ( 9 % )
tumours showed high expression of
CD44v3 . -
pubmed
Papillary
carcinomas were significantly more often high expressors of
CD44s and
CD44v6 than follicular
carcinomas ( p<0.001 for both ) . -
pubmed
Tumour recurrence and
cancer - related mortality were related to the reduced level of
CD44s ( p=0.049 and p=0.042 ) . -
pubmed
In univariate analysis ,
CD44s was the only significant prognostic factor for
disease - free survival ( p=0.0488 ) . -
pubmed
In multivariate analysis ,
CD44s and
thyroglobulin level were significant prognostic factors for
disease - free survival ( p=0.040 and p<0.001 , respectively ) . -
pubmed
The reduced level of
CD44s in
DTC patients seems to be an independent prognostic factor for unfavourable disease outcome . -
pubmed
A promising approach to the gene therapy of
PD is intrastriatal expression of
dopamine - synthesizing enzymes [
tyrosine hydroxylase (
TH ) and
aromatic L - amino acid decarboxylase (
AADC ) ] . -
pubmed
Therefore ,
TH and
AADC genes were introduced into the striatum in the lesioned side using separate AAV vectors in
parkinsonian rats , and the coexpression of
TH and
AADC resulted in better behavioral recovery compared with
TH alone . -
pubmed
Another strategy for gene therapy of
PD is the protection of dopaminergic neurons in the substantia nigra using an AAV vector containing a
glial cell line - derived neurotrophic factor (
GDNF ) gene . -
pubmed
Combination of
dopamine - supplement gene therapy and
GDNF gene therapy would be a logical approach to the treatment of
PD . -
pubmed
Patients presented slight
hypothyroidism with high titers of
antithyroperoxidase antibodies . -
pubmed
FINDINGS : Baseline studies indicated that the prevalence of
anaemia (
haemoglobin & lt ; 110 g / l ) was high ( 54 % ) among schoolchildren , particularly those with high intensities of hookworm and
schistosomiasis . -
pubmed
Fifteen months after deworming with
albendazole and
praziquantel the prevalence of
anaemia was reduced by a quarter and that of moderate - to - severe
anaemia (
haemoglobin & lt;90 g / l ) was reduced by nearly a half . -
pubmed
The cost per
anaemia case prevented by deworming schoolchildren was in the range US$ 6 - 8 , depending on the
haemoglobin threshold used . -
pubmed
The maintenance of
oxygen supply to the tissues during
anaemia involves complex cardiovascular adaptations , including an increase in cardiac output , reduced peripheral resistance and increased
oxygen extraction from
haemoglobin (
Hb ) . -
pubmed
Many potential reasons for
erythropoietin - induced
hypertension in
uraemic patients have been postulated , including increased blood viscosity as haematocrit rises , a reversal of hypoxic vasodilatation , increased blood volume that is not compensated by haemodialysis , ultrafiltration and impaired
nitric oxide synthesis , preventing vascular relaxation in response to increased blood viscosity . -
pubmed
As the interaction between
anaemia and
uraemia is very complex , it is not possible to derive the optimal
Hb concentration for individual
patients by using simple physiological or pathophysiological models and there is a need for good randomized controlled clinical trials to address this issue . -
pubmed
The clinical data with
ranolazine focuses on its use in
chronic stable angina , where it has been shown to increase exercise tolerance and decrease
angina compared with placebo and in combination with beta - blockers and
calcium - channel blockers . -
pubmed
The occurrence of
opportunistic infections depends on
CD4 count and rises with
CD4 decline . -
pubmed
Differential
cytokine and antibody responses to adult and larval stages of
Onchocerca volvulus consistent with the development of concomitant immunity . -
pubmed
The possibility of concomitant immunity and its potential mechanisms in
Onchocerca volvulus infection were examined by analyzing
cytokine and antibody responses to infective larval ( third - stage larvae [ L3 ] and molting L3 [ mL3 ] ) , adult female worm ( F - OvAg ) , and skin microfilaria ( Smf ) antigens in infected individuals in a region of hyperendemicity in Cameroon as a function of age . -
pubmed
Patients were stratified by : ( 1 ) prognostic factors ( age ( 75 - 79 or & gt ; or = 80 ) , Charlson comorbidity score ,
tumor size , nodal status , stage ,
ER ,
PR ,
creatinine ,
albumin ,
hemoglobin , and liver function tests ) , ( 2 ) local treatment ( lumpectomy , axillary lymph node dissection ( AxLND ) , radiation ( XRT ) , modified radical mastectomy ( MRM ) ) and ( 3 ) systemic treatment (
tamoxifen , chemotherapy ) . -
pubmed
BACKGROUND : Most
obese individuals have elevated concentrations of
interleukin-6 (
IL-6 ) and
tumor necrosis factor - alpha (
TNF - alpha ) , markers of
inflammation closely associated with
diabetes ,
hypertension , and
stroke . -
pubmed
Mesenteric / SAF ratio of
IL-6 ,
TNF - alpha ,
corticosterone , and gene profiling showed decrease of
inflammation after RYGB . -
pubmed
[ THE EVOLUTION OF THE GENETIC PROBLEM IN
THALASSEMIA ] . -
pubmed
The combination of
indole-3 - acetic acid (
IAA ) and
horseradish peroxidase (
HRP ) has recently been proposed as a novel
cancer therapy . -
pubmed
Intermittent
hypoxic exposure during light phase induces changes in
cAMP response element binding protein activity in the
rat CA1 hippocampal region : water maze performance correlates . -
pubmed
We postulate that IH elicits time - dependent changes in
CREB phosphorylation and nuclear binding that may account for decreased neuronal survival and spatial
learning deficits in the adult
rat . -
pubmed
We suggest that
CREB changes play an important role in the neurocognitive morbidity of
SDB patients . -
pubmed
BACKGROUND : The disease - associated form of
prion protein (
PrP(
res ) ) has been noted in lymphoreticular tissues in
patients with variant
Creutzfeldt - Jakob disease (
vCJD ) . -
pubmed
Presynaptic
cannabinoid CB ( 1 ) receptors are involved in the inhibition of the neurogenic vasopressor response during
septic shock in pithed
rats . -
pubmed
We conclude that in the initial phase of
septic shock , the activation of presynaptic
CB ( 1 ) receptors by endogenously formed
cannabinoids contributes to the inhibition of the neurogenic vasopressor response . -
pubmed
Biotin - rich , optically clear nuclei express
estrogen receptor - beta :
tumors with morules may develop under the influence of
estrogen and aberrant
beta - catenin expression . -
pubmed
Recent studies have indicated that aberrant
beta - catenin expression may be a common denominator for the morular formation of
tumors from various anatomic sites . -
pubmed
We investigated a possible role of
estrogen receptor ( ER )- beta in the occurrence of
tumors that form morules with
biotin - rich optically clear nuclei ( BROCN)(BROCN - family
tumors ) and its possible relationship with aberrant nuclear / cytoplasmic ( N / C )
beta - catenin expression . -
pubmed
We immunostained 14
BROCN - family tumors , including 6
low - grade adenocarcinomas of the fetal lung type , 3
papillary thyroid carcinomas of cribriform - morular variant ( CMV ) , 2
ovarian endometrioid tumors , 2 colonic
adenocarcinomas , and 1
gallbladder adenoma , as well as 4 cases of endometrial tissue with BROCN during gestation , for
ERbeta ,
ERalpha ,
progesterone receptor (
PgR ) ,
beta - catenin , and , on a subset of cases ,
c - Fos and
MIB-1 as well . -
pubmed
In the BROCN - family
tumors , the morular cells and budding glandular cells expressed
ERbeta in the cytoplasm and
BROCN , which overlapped with the N / C expression pattern of
beta - catenin . -
pubmed
In
CMV and ovarian endometrioid
tumors , nuclear expression of
ERalpha and
PgR were observed in association with
N / C beta - catenin expression only in the glandular component . -
pubmed
The present study indicates that N / C co - localization of
ERbeta and
beta - catenin is a feature common to the morules with
BROCN that appear in the
BROCN - family tumors from various anatomic sites . -
pubmed
Whether the
estrogen - signaling pathway and the
Wnt - signaling pathway have crosstalk , cooperating in the development of the BROCN - family
tumors , awaits further study . -
pubmed
We estimated the relative risk ( RR ) for each lipid parameter , adjusted for
C - reactive protein ,
homocysteine , body mass index , family history ,
hypertension ,
diabetes , postmenopausal hormone use , physical activity ,
alcohol intake , and blood draw parameters . -
pubmed
HDL - C - related ratios were the strongest contributors to predicting
CHD ( P<0.0001 ) . -
pubmed
CONCLUSIONS : Lower levels of
HDL - C may be a key discriminator of higher
CHD events among postmenopausal women . -
pubmed
HDL - C - related ratios ( such as TC /
HDL - C ) provide a powerful predictive tool independently of other known
CHD risk factors . -
pubmed
Regulation of
AKT1 expression by
beta - catenin /
Tcf /
Lef signaling in
colorectal cancer cells . -
pubmed
Several reports implicated
AKT in the molecular pathogenesis of different
human malignancies and overexpression of
AKT was recently demonstrated to be an early event in colorectal carcinogenesis . -
pubmed
To elucidate the regulation of
AKT expression in
colon cancer cells , we generated reporter constructs containing the
luciferase gene under the control of different regions derived from the
AKT1 promoter / enhancer . -
pubmed
Luciferase was stimulated 20- to 50 - fold in
SW480 ,
SW948 and
HCT116 CRC cells . -
pubmed
Coexpression of a constitutively active
beta - catenin mutant in
colon cancer cells further enhanced reporter gene activation from the
AKT1 promoter / enhancer , whereas it was downregulated by introduction of either wild - type
APC or
dnTcf-4 . -
pubmed
In addition , immunohistochemical staining of
tumor sections derived from
CRC patients showed elevated expression levels of
AKT1 , correlating with enhanced cytoplasmic / nuclear expression of
beta - catenin . -
pubmed
Finally , given the evidence that
ST is a form of
sensory epilepsy , new antiepileptic drugs should be tested for potential efficacy as they are developed ; such drugs may include novel
N - methyl - D - aspartate receptor antagonists , as well as
cannabinoids . -
pubmed
The particular endocrine picture of the graft may be explained by a modified
GH - hepatocyte interaction due to
cold ischemia during preservation resulting in a higher
IGF production . -
pubmed
The
diabetic patients had
ferritin levels of 346 mg / l and non -
diabetic patients had 218 mg / l ( p = 0.038 ) . -
pubmed
Protection against
Pseudomonas aeruginosa pneumonia and
sepsis - induced
lung injury by overexpression of
beta - defensin-2 in
rats . -
pubmed
The purpose of this study was to evaluate the effect of overexpression of
BD-2 on
lung injury to crudely investigate whether the function of
BD-2 in the lung attributed to both antimicrobial action and modulation of the immune response . -
pubmed
Recombinant
adenovirus carrying an expression cassette of
rat BD-2 or control adenovirus carrying empty vector was administered intratracheally to
Sprague - Dawley rats 48 h before performing
acute lung injury , which was induced either by
Pseudomonas aeruginosa infection or by cecal ligation and double puncture ( 2CLP ) . -
pubmed
Overexpression of
BD-2 reduced
alveolar damage ,
interstitial edema , and infiltration of neutrophils in both models . -
pubmed
Modulating the expression level of
BD-2 may serve as an approach to attenuate
lung injury . -
pubmed
Nerve growth factor in treatment and pathogenesis of
Alzheimer ' s disease . -
pubmed
One molecule that has received much attention in its potential therapeutic role in
AD is
nerve growth factor (
NGF ) . -
pubmed
This review will demonstrate data from
humans and
animals which promote
NGF as a potential therapeutic target by ( 1 ) outlining the hypothesis behind using
NGF for the treatment of
AD , ( 2 ) reviewing both the normal and
AD altered signaling pathways and effects of
NGF in the central nervous system ( CNS ) , and ( 3 ) examining the results of
NGF treatment obtained from
animal models of
AD and
AD patients . -
pubmed
The independent prognostic value of the biopsy results for forecasting eventual biochemical outcome and overall survival was tested with other factors ( the Gleason score , 1992 American Joint Committee on
Cancer tumor stage , pretreatment
prostate - specific antigen level , risk group , and
RT dose ) in a multivariate analysis . -
pubmed
Of the
tumors , 4 ( 7 % ; 1
plasmacytoma and 3
MMs ) were EBV - encoded RNA (
EBER)-positive with plasmablastic cytomorphologic features in 3 . -
pubmed
Inflammatory processes , such as phagocytosis , coagulation , and
vascular dilation , promote the release of
serine proteases by neutrophils , macrophages , mast cells , lymphocytes , and the epithelial or endothelial cells . -
pubmed
In conditions such as
infection ,
cancer ,
tissue injury during surgery ,
kidney disease ,
vascular disease , coagulation , and
diabetes , the concentrations of
Bik in plasma and urine are increased . -
pubmed
SUP markedly attenuated
seizure - induced hippocampal
neurodegeneration , dentate cell proliferation , and hippocampal
GFAP mRNA expression levels , prevented the loss of hippocampal
GAD65 protein and mRNA expression , and altered growth factor expression patterns . -
pubmed
SUP also enhanced pre -
seizure hippocampal levels of
BDNF ,
NGF , and IGF-1 , which may confer a neuroprotective hippocampal microenvironment that dampens the neuropathological response to and/or helps facilitate recovery from
SE to protect cognitive function . -
pubmed
Expression profile and prognostic importance in
prostate lesions of the
reverse transcriptase component of
human telomerase (
hTERT ) and of cyclin - dependent kinase inhibitor
p57 (
p57kip2a ) . -
pubmed
OBJECTIVES : To investigate expression of the
reverse transcriptase component of
human telomerase (
hTERT ) and of cyclin - dependent kinase inhibitor
p57 (
p57 ( kip2a ) ) in
prostate neoplasms and evaluate the relationship between these proteins and the Gleason score . -
pubmed
METHODS :
hTERT and
p57(
kip2a ) antibodies were studied by immunohistochemical methods in 70 prostate
adenocarcinomas ( 33 high - grade and 37
low - grade carcinomas ) , 29
benign prostate hyperplasias , and 19
prostatic intraepithelial neoplasias (
PIN ) . -
pubmed
RESULTS : Immunohistochemical histologic scores ( HSCOREs ) of
hTERT were significantly higher in the PIN group than in the
hyperplasia group ( P = 0.03 ) . -
pubmed
hTERT HSCOREs were not significantly different between
hyperplasias and
carcinomas or between
low and high - grade carcinomas . -
pubmed
p57 ( kip2a ) HSCOREs were significantly higher in
hyperplasias than other groups , and in
PINS than
carcinomas , but did not differ significantly between
low and high - grade carcinomas . -
pubmed
A significant negative correlation was observed between
hTERT and
p57 ( kip2a ) ( P = 0.007 ) in the
hyperplasia group . -
pubmed
Loss of
p57 ( kip2a ) control on
hTERT might have an important role in the development of
prostate cancer . -
pubmed
In 2006 the protein
TDP-43 was identified as the major ubiquitinated component deposited in the inclusion bodies found in two
human neurodegenerative diseases ,
amyotrophic lateral sclerosis and
frontotemporal lobar degeneration . -
pubmed
Now , in 2008 , several papers have been published in quick succession describing mutations in the
TDP-43 gene , showing they can be a primary cause of
amyotrophic lateral sclerosis . -
pubmed
There are many precedents in
neurodegenerative disease in which rare single - gene mutations have given great insight into understanding disease processes , which is why the
TDP-43 mutations are potentially very important . -
pubmed
A
VEGF trap inhibits the beneficial effect of
bFGF on vasoreactivity in corporal tissues of
hypercholesterolemic rabbits . -
pubmed
Previous studies have shown that intracorporal injection ( ICI ) of
basic fibroblast growth factor (
bFGF ) reverses some of the detrimental vasoreactivity effects of
hypercholesterolemia and increases
vascular endothelial growth factor (
VEGF ) expression . -
pubmed
Five new consanguineous families with
horizontal gaze palsy and
progressive scoliosis and novel
ROBO3 mutations . -
pubmed
Horizontal gaze palsy and
progressive scoliosis (
HGPPS ) is an
autosomal recessive neurologic disorder caused by homozygous or compound heterozygous mutations in the
ROBO3 gene on chromosome 11 . -
pubmed
The
ROBO3 gene does not appear to have an obvious hot spot area for mutations ; therefore , we recommend sequencing all exons and exon - intron boundaries in patients with clinical and/or radiologic features of
HGPPS . -
pubmed
Before treatment , the median level of WBC was 4.3 x 10(9)/L and the detection rate of abnormal promyelocyte on blood film was 85.8 % ; with immunophenotypic detection , the expression levels of
CD117 ,
CD34 ,
HLA - DR ,
CD7 ,
CD14 and
CD19 in
APL were found to be lower and the expression levels of
CD2 ,
CD33 and
MPO higher than those in other subtypes of
acute myelocytic leukemia (
AML ) ( both P & lt ; 0.01 ) . -
pubmed
The 4th
patient was a case of
LCH with primary pulmonary involvement diagnosed on the basis of HRCT and lavage with an immunohistochemical proof ( expression of
CD1 and of
protein S-100 ) of a high number of Langerhans cells . -
pubmed
Transcriptional interaction of an
estrogen receptor splice variant and
ErbB4 suggests convergence in gene susceptibility pathways in
schizophrenia . -
pubmed
Previously , we found that DNA sequence variation in the
estrogen receptor ( ER ) alpha gene , lower
ERalpha mRNA levels , and/or blunted
ERalpha signaling is associated with
schizophrenia . -
pubmed
In addition , we determined the extent to which
ERalpha interacts with
NRG1 -
ErbB4 , a leading
schizophrenia susceptibility pathway . -
pubmed
Reductions in the transcriptionally active form of
ErbB4 comprising the intracytoplasmic domain (
ErbB4 - ICD ) have been found in
schizophrenia , and we hypothesized that
ERalpha and
ErbB4 may converge to control gene expression . -
pubmed
Our findings demonstrate convergence between
ERalpha and
ErbB4 - ICD in the transcriptional control of
ERalpha - target gene expression and suggest that this may represent a convergent pathway that may be disrupted in
schizophrenia . -
pubmed
AIMS : Clinically ,
Chlamydia pneumoniae infection and its
heat shock protein 60 (
cHSP60 ) may contribute to atherogenesis ; however , its underlying mechanisms are largely unknown . -
pubmed
The objective of this study was to determine whether
cHSP60 could cause
endothelial dysfunction in
human coronary artery endothelial cells ( HCAECs ) and
porcine coronary arteries . -
pubmed
CONCLUSION :
cHSP60 directly induces
eNOS downregulation through oxidative stress and
MAPK activation in both HCAECs and
porcine coronary arteries , thereby causing
endothelial dysfunction . -
pubmed
[ Detection rate of
MAGE - A1 - A6 mRNA in the peripheral blood of
cancer patients ] . -
pubmed
The mRNA expression of 6
MAGE - A (
MAGE - A1 - A6 ) antigens by the
tumor focal cells and
cancer cells circulating in blood was studied in solid malignant and
benign neoplasms . -
pubmed
MAGE - A1 - A6 mRNA expression was detected in the
tumor focal cells in more than 90 % of cases of
cancer of the breast , lung , and stomach and
melanoma cell lines . -
pubmed
The detection rate of peripheral blood
MAGE - A1 - A6 - positive
tumor cells was 95 % in
lung cancer , 53 % in
corpus uteri cancer , 67 % in
gastric cancer , 63 % in
breast cancer , 33 % in
melanoma , and 42 % in
uterine myoma . -
pubmed
Efficacy of SSRIs on cognition of
Alzheimer ' s disease patients treated with
cholinesterase inhibitors . -
pubmed
BACKGROUND : This study examines the joint effect on cognition of selective
serotonin re - uptake inhibitors ( SSRIs ) and
cholinesterase inhibitors ( AChEIs ) in
depressed patients affected by
Alzheimer ' s disease (
AD ) living at home . -
pubmed
In the United Kingdom , the National Institute for Health and Clinical Excellence recommends etanercept , a
human recombinant tumour necrosis factor ( TNF ) receptor fusion protein , for moderate to severe
psoriasis patients who have failed conventional therapies . -
pubmed
Adalimumab , a fully
human , anti -
TNF monoclonal antibody , is approved for treatment of moderate to severe
psoriasis . -
pubmed
Gastric acid secretion ,
pepsinogen , and
gastrin were measured preoperatively in 14
patients who have developed
Barrett ' s esophagus ( Group I ) , and the results were compared to 24
patients who did not develop
Barrett ' s esophagus ( Group II ) . -
pubmed
CONCLUSIONS :
Barrett ' s esophagus in the esophageal stump was associated to high preoperative levels of gastric acid secretion ,
serum pepsinogen , and also
gastritis in the transposed stomach . -
pubmed
Phenotypic spectrum of
hereditary neuralgic amyotrophy caused by the
SEPT9 R88W mutation . -
pubmed
Mutations in the
septin 9 (
SEPT9 ) gene were recently identified in some
HNA patients . -
pubmed
The phenotypic spectrum of
HNA caused by
SEPT9 mutations is not well known . -
pubmed
OBJECTIVE : To characterise the phenotype of a large family of
HNA patients with the
SEPT9 R88W mutation . -
pubmed
Wider and more universal recognition of clinical hallmarks and genetic counselling are of diagnostic importance for
HNA caused by the
SEPT9 mutation . -
pubmed
A20 ( also known as
TNFAIP3 ) is a cytoplasmic protein that plays a key role in the negative regulation of
inflammation and immunity . -
pubmed
Polymorphisms in the A20 gene locus have been identified as risk alleles for multiple
human autoimmune diseases , and
A20 has also been proposed to function as a tumor suppressor in several
human B - cell lymphomas . -
pubmed
Next , we will delineate the signalling pathways importantly governed by
transforming growth factor beta (
TGFbeta ) in the control of
cardiac fibrosis . -
pubmed
We investigated the knockdown of individual
CerS in the
MCF-7 human breast adenocarcinoma cell line by using small - interfering RNA ( siRNA ) . -
pubmed
SGK3 is an
estrogen - inducible kinase promoting
estrogen - mediated survival of
breast cancer cells . -
pubmed
Recent study revealed that
SGK3 plays a pivotal role in
Akt /
protein kinase B independent signaling downstream of oncogenic
PI3KCA mutations in
breast cancer . -
pubmed
Here we report that
SGK3 is an
estrogen receptor (
ER ) transcriptional target and promotes
estrogen - mediated cell survival of
ER - positive breast cancer cells . -
pubmed
Through a meta - analysis on 22 microarray studies of
breast cancer in the Oncomine database , we found that the expression of
SGK3 is significantly higher ( 5.7 - fold , P & lt ; 0.001 ) in
ER - positive tumors than in
ER - negative tumors . -
pubmed
In
ER - positive breast cancer cells ,
SGK3 expression was found to be induced by
17beta - estradiol ( E(2 ) ) in a dose- and time - dependent manner , and the induction of
SGK3 mRNA by E(2 ) is independent of newly synthesized proteins . -
pubmed
Loss - of - function analysis indicated that
SGK3 is required for E(2)-mediated cell survival of
MCF-7 breast carcinoma cells . -
pubmed
Together , our study defines the molecular mechanism of regulation of
SGK3 by
estrogen / ER and provides a new link between the
PI3 K pathway and
ER signaling as well as a new
estrogen - mediated cell survival mechanism mediated by
SGK3 in
breast cancer cells . -
pubmed
Aromatase inhibitors ( AIs ) were more effective than
tamoxifen as a neoadjuvant endocrine therapy ( NAE ) for postmenopausal
women with
estrogen receptor ( ER )- positive breast cancer . -
pubmed
Predictive markers of neoadjuvant AIs may be
ER - rich ,
progesterone receptor (
PgR)-rich and
human epidermal growth factor receptor 2 ( HER2 )- negative tumors . -
pubmed
Pathological
tumor size , nodal status ,
Ki67 level , and
ER score are predictive for the survival of postmenopausal
women with
breast cancer who have been treated with NAE . -
pubmed
RESULTS : Here we analyze the 3D telomere dynamics by Q - FISH in the novel Hodgkin cell line
U - HO1 and its
non - receptor protein - tyrosine phosphatase N1 (
PTPN1 ) stable transfectant
U - HO1 -
PTPN1 , derived from a primary
refractory Hodgkin ' s lymphoma . -
pubmed
Novel role of mitochondrial
matrix metalloproteinase-2 in the development of
diabetic retinopathy . -
pubmed
Matrix metalloproteinase-2 (
MMP2 ) becomes activated and proapoptotic , and the therapies that inhibit the development of
diabetic retinopathy alleviate
MMP2 activation . -
pubmed
The authors sought to elucidate the possible mechanism by which activated
MMP2 contributes to
mitochondrial dysfunction . -
pubmed
METHODS : The effect of the regulation of
MMP2 on
mitochondrial dysfunction and the subcellular localization of the molecular chaperone important for mitochondrial integrity (
Hsp60 ) and gap junction protein
connexin 43 were investigated in retinal endothelial cells . -
pubmed
The results were confirmed in retinal mitochondria isolated from
diabetic mouse overexpressing
MnSOD and in the retinas of normal
rats that received intravitreal administration of
MMP2 . -
pubmed
In
mice , the overexpression of
MnSOD protected retinal mitochondria from
diabetes - induced increases in
MMP2 and decreases in
Hsp60 and
connexin 43 . -
pubmed
Better understanding of
MMP2 - mediated
mitochondrial damage could help identify new strategies for the treatment of this blinding disease . -
pubmed
Blood pressure - dependent and independent effects of
amlodipine and
angiotensin receptor blockers on the risk of
stroke . -
pubmed
In the male
patients ( n=169 , mean age : 61 years ) who had no apparent
carotid arterial stenosis and
cerebrovascular disease , a history of
CAD , current smoking , body mass index , blood pressure ,
hemoglobin A1c ,
serum low - density - lipoprotein cholesterol , estimated glomerular filtration rate and ultrasonic measures of CCA diameter were analyzed . -
pubmed
We aimed to compare the effects of
aspirin and prodrugs of
aspirin ( 1 - 5 ) on
human platelet aggregation stimulated by
ADP and
collagen and associated receptor expression (
GPIIb / IIIa and
P - selectin ) in platelet - rich plasma ( PRP ) and washed platelets ( WP ) . -
pubmed
The mechanism of prodrug - induced
platelet aggregation inhibition was explored by studying the effects of plasma and purified
human BuChE on aggregation . -
pubmed
KEY FINDINGS :
ST0702 , 2 , a
nicotinic acid -
aspirin codrug was equipotent with
aspirin with respect to inhibition of
collagen - induced
platelet aggregation . -
pubmed
While previous studies have addressed the role of
tumor necrosis factor ( TNF )- alpha and
matrix metalloproteinases (
MMPs ) in
HSK , the mechanistic link between
TNF - alpha and
MMPs in the pathogenesis of
HSK remains elusive . -
pubmed
CONCLUSIONS : Our findings shed new light on the pathogenesis of
HSK and open up new possibility of modulating the
TNF - alpha -
FAK -
ERK signaling cascade to pursue therapeutic measures for
HSK . -
pubmed
Understanding how the
tumor suppressor
p53 induces cell cycle arrest or apoptosis is critical for developing chemotherapeutic strategies . -
pubmed
Synergistic enhancement of
cancer therapy using a combination of
heat shock protein targeted
HPMA copolymer - drug conjugates and gold nanorod induced
hyperthermia . -
pubmed
In this study ,
tumor hyperthermia was utilized as a means to increase the active delivery of
heat shock protein (
HSP ) targeted
N -( 2 - hydroxypropyl ) methacrylamide (
HPMA ) copolymer - drug conjugates . -
pubmed
Following
hyperthermia , induced expression of
cell surface heat shock protein (
HSP )
glucose regulated protein 78 kDa (
GRP78 ) was utilized for targeted drug therapy . -
pubmed
Co - treatment with CCKsv also partially antagonizes
Ewing tumor cell growth stimulated by
CCK-8 . -
pubmed
Sry expression was deregulated in two out of the four tested male
rodent hepatocellular carcinoma ( rHCC ) cell lines . -
pubmed
Knockdown of
Sry robustly lowered anchorage - independent growth , invasiveness and tumorigenicity of
rHCC cells , whereas ectopic expression of
Sry conferred more malignant properties . -
pubmed
Low
CD4 count ( & lt ; 50 / mul ) had statistically significant association with
HIV / TB co - infection as compared to
HIV infection only ( P & lt ; 0.0001 ) . -
pubmed
Proteasome inhibition reduced
platelet aggregation by low
thrombin concentrations and ristocetin - stimulated agglutination through the
glycoprotein Ib - IX - V complex . -
pubmed
BACKGROUND : Elite controllers maintain high
CD4(+ ) T - cell counts and suppress
plasma human immunodeficiency virus ( HIV ) viremia in the absence of antiretroviral therapy ( ART ) . -
pubmed
RESULTS :
CD4(+ ) T - cell counts were similar between elite controllers and
HIV - negative controls but significantly lower in ART recipients with suppressed
viremia . -
pubmed
Patients with metastatic
pancreatic cancer presenting with increased values of
C - reactive protein do not respond to
gemcitabine . -
pubmed
Furthermore ,
human Paca44 pancreatic ductal adenocarcinoma cells were seeded and cultured in 0.5 % FBS containing growth medium plus / minus 1 muM
gemcitabine plus / minus recombinant
human interleukin ( IL )- 6 . -
pubmed
In vitro , the induction of
STAT3 phosphorylation by recombinant
human IL-6 promoted
pancreatic ductal adenocarcinoma cell survival during
gemcitabine treatment . -
pubmed
In particular , the
inflammation biomarkers
C - reactive protein ,
IL-6 , and
IL-1alpha could indicate the prognostic benefit of
gemcitabine chemotherapy and should now be tested in prospective
patient - controlled trials . -
pubmed
The mitochondrial transmembrane potential of the
tumor cells was detected by laser scanning confocal microscopy , and the activity of
caspase-3 , - 8 , - 9 and - 12 was determined . -
pubmed
The results of the present study indicate that psPEF may induce apoptosis in a
cervical cancer xenograft through the endoplasmic reticulum stress and
caspase - dependent signaling pathways . -
pubmed
Induction of
H2AX phosphorylation in
tumor cells by
gossypol acetic acid is mediated by
phosphatidylinositol 3 - kinase ( PI3 K ) family . -
pubmed
Thus , we further examined the possible mechanisms of
GAA to induce
gammaH2AX in
tumor cells . -
pubmed
DNA dependent protein kinase (
DNA - PK ) - proficient and -deficient cells ,
human glioma cell lines
M059 K and
M059J , were also used to evaluate the
kinases responsible for GAA induced
H2AX phosphorylation . -
pubmed
Lentivirus - mediated RNAi knockdown of the gap junction protein ,
Cx43 , attenuates the development of
vascular restenosis following
balloon injury . -
pubmed
In the present study , we investigated the role of the gap junction ( GJ ) protein ,
connexin 43 (
Cx43 ) , in the development of
vascular restenosis . -
pubmed
In addition , the mRNA and protein expression of
Cx43 was temporarily decreased at 7 days , and subsequently increased at 14 and 28 days following
balloon injury , as shown by RT - PCR and western blot analysis . -
pubmed
To determine the involvement of
Cx43 in
vascular restenosis , the
lentivirus vector expressing shRNA targeting
Cx43 ,
Cx43 - RNAi - LV , was used to silence
Cx43 in the
rat carotid arteries . -
pubmed
The knockdown of
Cx43 effectively attenuated the development of
intimal hyperplasia and
vascular restenosis following
balloon injury . -
pubmed
Thus , our data indicate the vital role of the GJ protein ,
Cx43 , in the development of
vascular restenosis , and provide new insight into the pathogenesis of
vascular restenosis . -
pubmed
Cx43 may prove to be a novel potential pharmacological target for the prevention of
vascular restenosis following PCI . -
pubmed
A higher percentage of
patients with
hemolysis had
anticardiolipin IgM ( p - value=0.002 ) . -
pubmed
Associations of low platelet count and
hemolysis were found with
antiphospholipid syndrome and anticardiolipin
IgM positivity , respectively . -
pubmed
R4 Regulator of G Protein Signaling (
RGS ) Proteins in
Inflammation and Immunity . -
pubmed
Additional
G protein independent functions of
RGS13 have been uncovered in gene expression in B lymphocytes and mast cell - mediated
allergic reactions . -
pubmed
We also discuss approaches to target
RGS proteins therapeutically , which represents a virtually untapped strategy to combat exaggerated immune responses leading to
inflammation . -
pubmed
Lack of anti - tumor activity by anti -
VEGF treatments in
hepatic hemangiomas . -
pubmed
Recently , anti -
vascular endothelial growth factor ( anti -
VEGF ) agents have been described in the literature as a valid treatment option for symptomatic
liver hemangiomas , but only limited evidence supports this notion . -
pubmed
The purpose of this study was to elucidate whether or not the administration of anti -
VEGF agents can reliably achieve a size reduction in
liver hemangiomas . -
pubmed
Our data do not support the application of anti -
VEGF agents for the treatment of
hepatic hemangiomas . -
pubmed
The receiver operating characteristic ( ROC ) analysis were also performed for evaluating
nesfatin-1 and
orexin - A in distinguishing
children with
malnutrition from healthy controls . -
pubmed
ROC analysis demonstrated that
nesfatin-1 and
orexin - A can not be used to distinguish
children with
malnutrition from healthy controls ( AUC : 0.620 , p=0.061 for
nesfatin-1 and AUC : 0.584 , p=0.190 for
orexin - A ) . -
pubmed
Phenotypic observations in "
hypotrichosis with
juvenile macular dystrophy " ( recessive
CDH3 mutations ) . -
pubmed
PURPOSE : Recessive mutations in
CDH3 cause "
hypotrichosis with
juvenile macular dystrophy , " typically recognized by the presence of prominent dermatological features . -
pubmed
CONCLUSIONS : Ophthalmologists should consider the diagnosis of
CDH3 - related
retinopathy in
individuals with such clinical features whether or not there is frank
hypotrichosis . -
pubmed
These observations prompted the US FDA to revise statin labels to include a warning of an increased risk of incident
diabetes mellitus as a result of increases in
glycosylated hemoglobin (
HbA1c ) and fasting plasma
glucose . -
pubmed
LY294002 induces differentiation and inhibits invasion of
glioblastoma cells by targeting
GSK-3beta and
MMP . -
pubmed
Here we show that the traditional
phosphatidylinositol 3 kinase (
PI3 K ) inhibitor
LY294002 is capable of inducing differentiation of
C6 glioblastoma cells characterized by morphological changes to astrocytic phenotype , increase in differentiation marker protein
glial fibrillary acidic protein and inhibition of proliferation . -
pubmed
Taken together , these findings suggest differentiation - inducing and invasion - inhibitory effectiveness of
LY294002 in
glioblastomas , most likely involving inhibition of
GSK-3beta and
MMP respectively . -
pubmed
Low - Density Lipoprotein Cholesterol , Non - High - Density Lipoprotein
Cholesterol ,
Triglycerides , and
Apolipoprotein B and Cardiovascular Risk in Patients With
Manifest Arterial Disease . -
pubmed
Low - density lipoprotein cholesterol (
LDL - C ) only partly represents the atherogenic lipid burden , and a growing body of evidence suggests that non - high - density lipoprotein
cholesterol ( non - HDL - C ) ,
triglycerides , and
apolipoprotein B (
apoB ) are more accurate in estimating lipid - related
cardiovascular disease risk . -
pubmed
Our objective was to compare the relation among
LDL - C , non - HDL - C ,
triglycerides , and
apoB and the occurrence of future vascular events and mortality in
patients with manifest
arterial disease . -
pubmed
The relation among
LDL - C , non -
HDL - C , and cardiovascular events was comparable in patients with
cerebrovascular disease ,
coronary artery disease , or
polyvascular disease and absent in those with
aneurysm of abdominal aorta or
peripheral artery disease . -
pubmed
In conclusion , in patients with a history of cerebrovascular , coronary artery , or
polyvascular disease , but not
aneurysm of abdominal aorta or
peripheral artery disease , higher levels of
LDL - C and non -
HDL - C are related to increased risk of future MACE and of comparable magnitude . -
pubmed
BACKGROUND :
TRPV4 , a non - selective cation channel , is involved in lipometabolism and
atherosclerosis . -
pubmed
This study may serve as an important first step for further investigation into the roles of
TRPV4 in macrophage - derived foam cell formation in
atherosclerosis . -
pubmed
ATM mutation and radiosensitivity : An opportunity in the therapy of
mantle cell lymphoma . -
pubmed
ATM is the most frequently mutated gene in
MCL and recent experimental evidence demonstrated that this mutational status can be taken advantage of using radiotherapy . -
pubmed
Mechanosensory Stimulation Evokes Acute
Concussion - Like Behavior by Activating
GIRKs Coupled to
Muscarinic Receptors in a Simple
Vertebrate . -
pubmed
Head skin stimulation activates a cholinergic pathway which then opens
G protein - coupled inward - rectifying potassium channels (
GIRKs ) via postsynaptic
M2 muscarinic receptors to inhibit brainstem neurons critical for the initiation and maintenance of swimming for up to minutes and can explain many features commonly observed immediately after
concussion . -
pubmed
We propose that some acute symptoms of
concussion in
vertebrates can be explained by the opening of
GIRKs following mechanosensory stimulation to the head . -
pubmed
Neuropsychiatric Manifestations of Pediatric
NMDA Receptor Autoimmune Encephalitis : A Case Series From a Tertiary Care Center in India . -
pubmed
Objective : Although psychiatric manifestations are one of the most common presentations of pediatric
N - methyl - D - aspartate receptor (
NMDAR )
encephalitis , there is a lack of studies that characterize psychiatric aspects of this disorder . -
pubmed
POU2F1 promotes growth and metastasis of
hepatocellular carcinoma through the
FAT1 signaling pathway . -
pubmed
Increasing evidence suggests that
POU domain class 2 transcription factor 1 (
POU2F1 ) participates in carcinogenesis and
cancer progression via promotion of cell proliferation and metastasis ; however , the functional role of
POU2F1 in
hepatocellular carcinoma (
HCC ) is largely unknown . -
pubmed
In this study , we determined that
POU2F1 was significantly up - regulated in
HCC tumor tissue and cell lines . -
pubmed
We demonstrated that
POU2F1 over - expression promoted
HCC cell proliferation , colony formation , migration , and invasion , while silencing of
POU2F1 inhibited these malignant phenotypes . -
pubmed
In vivo experiments indicated that knockdown of
POU2F1 inhibited
HCC cell metastasis and xenograft growth , whereas ectopic expression of
POU2F1 promoted these cellular functions . -
pubmed
Functionally , we demonstrated that
POU2F1 knockdown induced growth suppression and metastasis inhibition of
HCC cells and inactivated the
FAT1 pathway , indicating that
POU2F1 is a potential novel therapeutic target in
HCC . -
pubmed
PURPOSE : Though advanced and
metastatic epidermal growth factor receptor 2 ( HER2 )- positive disease is not curable , a small proportion of
patients with
HER2 - positive metastatic
breast cancer remain in prolonged complete remission with anti -
HER2 treatment . -
pubmed
We hypothesized that some cases of
HER2 - positive metastatic
breast cancer may be curable . -
pubmed
METHODS : We retrospectively evaluated the data of
patients diagnosed with
HER2 - positive metastatic
breast cancer who received trastuzumab for more than 2 years as the first - line treatment . -
pubmed
Dynamic disorganization of synaptic
NMDA receptors triggered by autoantibodies from
psychotic patients . -
pubmed
Using a combination of single molecule - based imaging approaches , we here ascertain the presence of circulating autoantibodies against
glutamate NMDA receptor (
NMDAR - Ab ) in about 20 % of psychotic
patients diagnosed with
schizophrenia and very few healthy subjects . -
pubmed
We unveil that
NMDAR - Ab from
psychotic patients alter NMDAR synaptic transmission , supporting a pathogenically relevant role . -
pubmed
Thyroperoxidase (
TPO ) activity , was reduced in
DM , and MSC treatment did not normalize
TPO . -
pubmed
TP53 Mutation in Correlation to Immunohistochemical Expression of
P53 Protein in Patients with
Hepatocellular Carcinoma . -
pubmed
BACKGROUND : Mutations causing
p53 inactivation are among the most common genetic alterations in
human malignant
tumours including
hepatocellular carcinoma . -
pubmed
Detection of
p53 gene mutations in patients with
hepatocellular carcinoma (
HCC ) should provide relevant data for the patients from the Republic of Macedonia and should allow the survivals additional therapeutic option as is gene therapy . -
pubmed
AIM : We aimed to detect
p53 gene mutations in
HCC tissue , and to correlate them with the immunoexpression of
p53 protein and multiple clinicopathologic characteristics of a
tumour . -
pubmed
Tumour tissue samples were immunostained for
p53 and detection of
p53 gene mutations was performed by polymerase chain reaction followed by Sanger sequencing . -
pubmed
All patients with
p53 mutations had
cirrhosis . -
pubmed
The expression and clinical significance of
GADD45A in
breast cancer patients . -
pubmed
Background : Growth arrest and
DNA - damage - inducible protein 45 alpha (
GADD45A ) was previously found to be associated with risk of several kinds of
human tumors . -
pubmed
Here , we studied the expression and clinical significance of
GADD45A in
breast cancer . -
pubmed
Methods : We performed an immunohistochemical study of
GADD45A protein from 419
breast cancer tissues and 116 adjacent
non - neoplastic tissues . -
pubmed
Results : Significantly high
GADD45A expression were observed in
breast cancer tissues compared with adjacent
non - neoplastic tissues ( P & lt ; 0.001 ) and were independently correlative with
estrogen receptor negative ( P = 0.028 ) and high
Ki-67 index ( P & lt ; 0.001 ) . -
pubmed
Kaplan - Meier survival analysis revealed that patients with high
GADD45A expression levels had a worse long - term prognosis in triple negative
breast cancer ( P = 0.041 ) , but it was not an independent prognostic factor in multivariate analysis ( P = 0.058 ) . -
pubmed
Conclusions :
GADD45A expression levels are significantly correlative with
estrogen receptor status and
Ki-67 index in
human breast cancer . -
pubmed
Patients with triple negative
breast cancer might be stratified into high risk and low risk groups based on the
GADD45A expression levels . -
pubmed
Synergistic inhibition of aggressive
breast cancer cell migration and invasion by cytoplasmic delivery of anti -
RhoC silencing RNA and presentation of
EPPT1 peptide on " smart " particles . -
pubmed
Overexpression of
RhoC protein in
breast cancer patients has been linked to increased
cancer cell invasion , migration , and metastases . -
pubmed
Suppressing
RhoC expression in aggressive
breast cancer cells using silencing RNA ( siRNA ) molecules is a viable strategy to inhibit the metastatic spread of
breast cancer . -
pubmed
We evaluated the efficacy of
EPPT1 peptides presented on the free tips of the
PEG brush to function as a targeting ligand against underglycosylated
MUC1 (
uMUC1 ) receptors overexpressed on the surface of metastatic
breast cancer cells . -
pubmed
Results show that " smart " nanoparticles successfully delivered anti -
RhoC siRNA into the cytoplasm of aggressive
SUM149 and
MDA - MB-231 breast cancer cells , which resulted in a dose - dependent inhibition of cell migration and invasion . -
pubmed
Moreover , aneuploidy causes up - regulation of the
JNK pathway throughout the posterior midgut , and specific inhibition of
JNK signaling in ISCs is sufficient to prevent
dysplasia . -
pubmed
Erdheim - Chester disease (
ECD ) , a rare form of
non - Langerhans cell histiocytosis , is characterized by the infiltration of foamy
CD68 + and
CD1a- histiocytes into multiple organ systems . -
pubmed
Central nervous system ( CNS ) involvement has recently been reported to be a poor prognostic factor when treating
ECD with
interferon alpha . -
pubmed
We report the case of a 66 - year - old Japanese
patient with
ECD involving the CNS who harbored the
BRAF V600E mutation and also concomitantly developed
polycythemia vera with the
JAK2 V617F mutation . -
pubmed
Fanconi Anemia and
Ataxia Telangiectasia in Siblings who Inherited Unique Combinations of Novel
FANCA and
ATM Null Mutations . -
pubmed
A unique consanguineous family with 2
genomic instability disorders ,
Fanconi anemia and
ataxia telangiectasia , revealed exceptional combinations of null mutations in the
FANCA and
ATM genes . -
pubmed
Two siblings with
Fanconi anemia had novel homozygous consecutive microdeletions ( c.1361 - 1370delCCTCCTTTGG , c.1374delC ) adjoined to upstream 65 nucleotide direct tandem repeats and deletion hotspot motifs in the
FANCA gene . -
pubmed
The sibling with
ataxia telangiectasia revealed a homozygous p. Arg2993Stop ( c.8977C>T ) null mutation in the
ATM gene . -
pubmed
Early Functional Outcomes for Pediatric
Patients Diagnosed with
Anti - N - Methyl - D - Aspartate Receptor Encephalitis during Inpatient Rehabilitation . -
pubmed
OBJECTIVE : The aims of the current study were to characterize the demographic and clinical presentation of pediatric
patients diagnosed with
anti - N - methyl - D - aspartate receptor encephalitis who require inpatient rehabilitation , to examine early functional outcomes , and to investigate predictors of early recovery . -
pubmed
DESIGN : A retrospective chart review was conducted for 27 pediatric
patients diagnosed with
anti - N - methyl - D - aspartate receptor encephalitis who received intensive inpatient neurorehabilitation . -
pubmed
CONCLUSION : Pediatric
patients diagnosed with
anti - N - methyl - D - aspartate receptor encephalitis displayed significant functional gains during inpatient rehabilitation , despite persistent functional deficits at discharge , suggesting the need for ongoing monitoring and intervention . -
pubmed
TO CLAIM CME CREDITS : Complete the self - assessment activity and evaluation online at http://www.physiatry.org/JournalCME CME OBJECTIVES : Upon completion of this article , the reader should be able to ( 1 ) Recognize the clinical presentation of
anti - N - methyl - D - aspartate receptor encephalitis in pediatric
patients , ( 2 ) Appreciate the role of rehabilitation in the care of the pediatric
patient with
anti - N - methyl - D - aspartate receptor encephalitis , and ( 3 ) Identify demographic and clinical variables that predict poor functional outcomes after rehabilitation in pediatric
patients with
anti - N - methyl - D - aspartate receptor encephalitis . -
pubmed
In the presence of the
EpCAM expressing
hepatocellular carcinomas cell line of
HepG2 , the specific immune recognition ( Anti -
EpCAM /
EpCAM ) led to an obvious change of the electron transfer ability . -
pubmed
Notably , endothelial vasodilatation of mesenteric arteries was impaired in SHR adolescent offspring exposed to prenatal
hypoxia , vascular responses to
acetylcholine (
ACh ) and
sodium nitroprusside (
SNP ) were reduced , as well as plasma
nitric oxide levels and expression of
endothelial nitric oxide synthase (
eNOS ) in vessels were decreased . -
pubmed
Moreover , mesenteric arteries in SHR offspring following prenatal
hypoxia showed enhanced constriction responses to
phenylephrine ( PE ) , associated with up - regulated activities of
L - type calcium channel (
Ca2 + -dependent ) ,
RhoA /
Rock pathway signaling (
Ca2 + -sensitization ) , and intracellular
Ca2 + flow . -
pubmed
The Impact of
Vitamin D Receptor Gene Polymorphisms on the Susceptibility of
Diabetic Vascular Complications : A Meta - Analysis . -
pubmed
Background : To determine whether
vitamin D receptor (
VDR ) gene polymorphisms are correlated with susceptibility to
diabetic vascular complications . -
pubmed
Our results showed that there was no correlation between
VDR gene
TaqI variants and
diabetic nephropathy (
DN ) or
diabetic retinopathy (
DR ) susceptibility . -
pubmed
In comparison with
diabetic patients without
DN , there was a link between the
VDR gene
ApaI variant and
DN susceptibility under allelic model ( p = 0.029 ) in all populations . -
pubmed
The
VDR gene FokI variant was also correlated with
DN susceptibility under the recessive model ( p = 0.027 ) in the Asian subgroup . -
pubmed
In comparison with
diabetic patients without
DR , we identified a link between the
VDR gene
ApaI variant and DR susceptibility under the dominant model ( p = 0.034 ) in all populations . -
pubmed
Conclusions : The
VDR gene
BsmI ,
ApaI , and
FokI gene variants are associated with
DN and
DR susceptibility . -
pubmed
No association was found between the
VDR gene
TaqI gene variants and
diabetic vascular complications . -
pubmed
The body growth of
DEK affected
rats was similar to that of normal
rats before the development of
DM but was attenuated with the deterioration of
DM . -
pubmed
There was a marked difference in the etiology of
DEK by gender :
DM phenotypes including
polyuria ,
polydipsia , and
hyperglycemia ( nonfasting blood
glucose over 300 mg / dl ) were found in male
rats aged over 10 weeks but not in female
rats . -
pubmed
The cumulative incidence of
DM in
DEK males at the age of 30 weeks was 44.8 % . -
pubmed
Oral
glucose tolerance tests showed
glucose intolerance and decreased
insulin secretion in response to
glucose loading in affected males , features which were exacerbated with age . -
pubmed
Affected males exhibited disorganized architecture of pancreatic islets , decreased numbers of beta cells , and markedly decreased expression of
insulin , despite no pathological findings of
hemorrhage or infiltration of inflammatory cells in the pancreatic islet . -
pubmed
Serum
alanine / aspartate aminotransferases (
ALT /
AST ) , liver
glutathione (
GSH ) depletion , as well as the inflammatory
cytokines , such as
tumor necrosis factor - alpha (
TNF - alpha ) ,
interleukin-1beta (
IL-1beta ) ,
inducible nitric oxide synthase (
iNOS ) , and
cyclooxygenase-2 (
COX-2 ) , were analyzed to indicate the underlying protective effects of
Rb1 against
APAP - induced
hepatotoxicity with significant inflammatory responses . -
pubmed
In conclusion , experimental data clearly demonstrated that
Rb1 exhibited a remarkable liver protective effect against
APAP - induced
ALI , partly through regulating
MAPK and
PI3K /
Akt signaling pathways - mediated inflammatory responses . -
pubmed
Pineoblastoma is uniquely tolerant of mutually exclusive loss of
DICER1 ,
DROSHA or
DGCR8 . -
pubmed
Potential role of full - length and nonfull - length
progranulin in affecting
aortic valve calcification . -
pubmed
The
progranulin (
PGRN ) is an important immunomodulatory factor in a variety of
inflammatory diseases , including
rheumatoid arthritis ,
osteoarthritis ,
inflammatory bowel disease and
pneumonia . -
pubmed
In primary
porcine VICs ( pVICs ) ,
PGRN downregulated
TNF - alpha and
alpha - SMA which was accompanied by downregulation of
RUNX2 ,
OPN ,
OCN ,
alkaline phosphatase activity and
calcium deposition , effects pointing to reduced
inflammation , myofibroblastic and osteoblastic transition under calcifying conditions . -
pubmed
However ,
45 - GRN overexpression promoted
OM - induced
calcification through activating the
Smad1 / 5 / 8 ,
NF - kappaB and
AKT signaling pathways . -
pubmed
Collectively , this study provides new insight into the pathogenesis of
CAVD , indicating that
PGRN is a stratagem in mitigating
valve fibrosis / osteoblastic differentiation , and also presenting
45 - GRN as a potential target for the treatment of
CAVD . -
pubmed
Melatonin inhibits the endoplasmic reticulum stress - induced ,
C / EBP homologous protein - mediated pathway in acute
pancreatitis . -
pubmed
The RNA interference method was used to determine the potential role of
CHOP in
AR42J cells during
AP . -
pubmed
Increased cerebrospinal fluid
YKL-40 levels are associated with disease severity of
neuromyelitis optica spectrum disorders . -
pubmed
YKL-40 , as a new inflammatory marker , has been studied in many
autoimmunity and
CNS diseases . -
pubmed
Our aim of this study was to investigate cerebrospinal fluid ( CSF ) and serum
YKL-40 levels in
patients with
NMOSD and their association with disease severity . -
pubmed
METHODS : We measured
CSF and serum
YKL-40 levels in 29
patients with
NMOSD and 21 age- and sex - matched controls . -
pubmed
We analyzed the associations between CSF
YKL-40 levels and the clinical variables of
NMOSD . -
pubmed
RESULTS : Compared to controls ,
patients with
NMOSD had significantly higher CSF
YKL-40 levels . -
pubmed
CONCLUSIONS :
YKL-40 could be a
NMOSD severity biomarker and a potential target for
NMOSD treatment . -
pubmed
Accumulating evidence suggests that
severe acute respiratory syndrome coronavirus 2 (
SARS - CoV2 ) is associated with
hyper inflammation characterized by excessive release of pro - inflammatory cytokines known as a
cytokine storm . -
pubmed
In the midst of
cytokine storm and
coagulopathy , anti - viral agents alone will not provide the much needed therapeutic effect . -
pubmed
Hence , the need to combine anti - inflammatory agents such as
interferons ,
angiotensinogen converting enzyme ( ACE ) 2 inhibitors ,
interleukin - 6 (
IL-6 ) , and
Janus kinase ( JAK ) family inhibitors , anticoagulants and other agents involved in
inflammation resolution . -
pubmed
Keywords : COVID-19 ; SARS - CoV2 ;
cytokine storm ;
coagulopathy and anti - inflammatory . -
pubmed
Our results indicate that
trelagliptin reduced plasma lipid levels in
NAFLD mice by reducing
triglycerides , total
cholesterol ,
low - density lipoprotein cholesterol , and high - density lipoprotein
cholesterol . -
pubmed
In addition ,
trelagliptin ameliorated oxidative stress in the liver of
NAFLD mice by reducing
malondialdehyde and increasing the levels of
reduced glutathione and
superoxide dismutase activity . -
pubmed
This article addresses how guidance for ophthalmologists on managing
patients with
retinal disease receiving intravitreal injections of
anti - vascular endothelial growth factor (
VEGF ) during the pandemic should be adapted to the local epidemic pressure , with more or less stringent measures implemented according to the ebb and flow of the pandemic . -
pubmed
METHODS : The Vision Academy 's membership of international
retinal disease experts analyzed guidance for anti -
VEGF intravitreal injections during the COVID-19 pandemic and graded the recommendations according to three levels of increasing epidemic pressure . -
pubmed
METHODS : A multi - centric cross - sectional study in the southeast of France explored the relation between pharmaco - resistance to psychotropic drugs and the prevalence of duplications or polymorphisms of
CYP2D6 associated with an ultra - rapid phenotype in
children and adolescents with severe
mental health disease . -
pubmed
We also demonstrate that
MRSA infection leads to increased activation of
MMP-9 and
MMP-2 in RPE cells , while microglia expressed only
MMP-9 in MRSA - infected cells . -
pubmed
Immunoglobulins in
allergic broncho - pulmonary aspergillosis (
ABPA ) . -
pubmed
Previously , we have found that the level of
glucocorticoid receptor and its mRNA in
hepatocellular carcinoma was significantly higher than that of the adjacent liver tissue . -
pubmed
This correlated well with the elevated serum
alpha - fetoprotein levels in
patients with
hepatocellular carcinoma . -
pubmed
Recently , a female hormone ,
progesterone , has been found to inhibit the expression of
alpha - fetoprotein in
hepatoma cells . -
pubmed
These results together with our hypothesis that the expression of
alpha - fetoprotein is regulated by
glucocorticoid receptor complex in proliferating
hepatocellular carcinoma cells lead to the conclusion that
steroid hormones and/or their antagonists may interfere with the function of
glucocorticoid receptors in
tumors , consequently regulate
tumor growth . -
pubmed
We reevaluated the published data on the natural history of
FOP and discovered an array of developmental gradients ( characteristic patterns of disease expression ) similar to
developmental anomalies induced by pleiotropic mutations of the
decapentaplegic (
dpp ) locus in
Drosophila melanogaster . -
pubmed
The developmental similarities between
decapentaplegic in the
fly and
FOP in
man suggest a useful model for the study of
FOP . -
pubmed
In the treatment of
human cancer , the efficacy of the adoptive transfer of lymphokine - activated killer ( LAK ) cells combined with
interleukin 2 (
IL2 ) has been emphasized . -
pubmed
However , administration of large doses of
IL2 may cause significant adverse effects , such as "
capillary leak syndrome " . -
pubmed
By an immunochemical method ( treatment of sera with staphylococca reagent ) specific
rubella IgM were found in 7 ( 100 % ) pregnant women who had experienced clinically manifest
rubella , and in 6 ( 14.3 % ) pregnant women with asymptomatic
rubella . -
pubmed
Myoglobin ( Mb ) levels in pooled urine samples were investigated and compared in
patients with different types of
hereditary progressive muscular dystrophies (
MD ) . -
pubmed
Procoagulant and
plasminogen activator activities of bronchoalveolar fluid in
patients with
pulmonary sarcoidosis . -
pubmed
Current evidence suggests that intraalveolar procoagulant ( PC ) and
plasminogen activator (
PA ) activities may be important determinants of local
fibrin turnover in
lung injury . -
pubmed
In this study , we measured the PC and
PA activities in cell - free bronchoalveolar lavage fluid ( BALF ) obtained from 17
patients with
pulmonary sarcoidosis and 12 normal
volunteers . -
pubmed
Mean
PC activity in the
sarcoidosis group was significantly elevated ( 102 + /- 25 versus 31.5 + /- 8.1 tissue
thromboplastin units / ml ; p less than 0.002 ) , with 6 of 17
patient values beyond the 95 % confidence limits of normals . -
pubmed
In contrast ,
PA activity tended to be lower in the
sarcoidosis group ( 0.54 + /- 0.094 versus 0.643 + /- 0.106 Plough units / ml , p less than 0.3 ) , and this difference became significant when
PA was normalized to total protein ( p less than 0.001 ) . -
pubmed
The ratio of procoagulant activity compared to
plasminogen activator (
PC / PA ) was greater in the
patients with
sarcoidosis than normals ( 258 + /- 54 versus 40.3 + /- 6.4 ; p less than 0.001 ) . -
pubmed
In the
sarcoidosis group , the
PC / PA ratio correlated weakly with the number and percentage of lymphocytes retrieved by BAL . -
pubmed
We conclude that in
pulmonary sarcoidosis , abnormal expression of procoagulant and
plasminogen activator activities in alveolar fluid may favor accumulation of
fibrin matrix at inflammatory foci . -
pubmed
All
coagulation factor activities fell with
shock and decreased further with resuscitation in both groups . -
pubmed
Inhibition by
interferon preparations of a solid
malignant tumour and
pulmonary metastasis in
mice . -
pubmed
Production of
migration inhibition factor - active
lymphokine by liver granulomas and spleens of
schistosome - infected nu / nu
mice is suggestive of the immune role of B cells in the
granulomatous inflammation . -
pubmed
Biorich medium alone had an apparent protective effect resulting in amelioration of the
cytotoxic effect of
Ara - C. Cell cycle analysis of eight subjects showed significant recruitment into S - phase following pre - treatment with
cytokines . -
pubmed
The
A1 - AR agonist binding inhibition evoked by
unsaturated FA in many respects is similar to that observed previously following
ischaemia and may be contributory to the increased excitability of post - ischaemic brain . -
pubmed
One
patient with
pouchitis pretransplant became negative for
antineutrophil cytoplasmic antibody posttransplant but continued to have
pouchitis . -
pubmed
Alpha - fetoprotein -
concanavalin A binding as a marker to discriminate between
germ cell tumours and
liver diseases . -
pubmed
In order to differentiate whether slight
alpha - fetoprotein (
AFP ) increases observed in any patient are due to
germ cell tumours (
GCT ) or to
liver diseases ( including
hepatotoxicity of chemotherapy ) , we measured the binding ratio of the
AFP to concanavalin A (
ConA ) . -
pubmed
Considering a cut - off value to be a
ConA binding ratio of 15 % , we distinguished
AFP produced by GCT ( & gt ; 15 % ) from
AFP produced by tumoral and
non - tumoral liver diseases ( & lt ; or = 15 % ) with a sensitivity of 98 % and specificity of 100 % . -
pubmed
We did not distinguish
AFP produced by tumoral and
non - tumoral liver diseases . -
pubmed
ConA binding ratio may be a sensitive index to distinguish whether an increase of
AFP concentration as low as 15 U / ml in a
GCT patient during the follow - up is produced by the
tumour or by
liver dysfunction ( including
hepatotoxicity of chemotherapy ) . -
pubmed
The discovery of the
plant alkaloid
20 ( S ) camptothecin (
CPT ) , which displayed potent antitumor activity in preclinical trials , has led to the identification of a novel target of
cancer chemotherapy : the nuclear enzyme
topoisomerase I. -
pubmed
The mechanism by which
CPT induces
cytotoxicity is the topic of continued research , but appears to be mediated by the stabilisation of transient " cleavable "
topoisomerase I - DNA complexes . -
pubmed
beta - Glucuronidase in common duct bile , methodological aspects , variation of pH optima and relation to
gallstones . -
pubmed
beta - Glucuronidase of
human or
bacterial origin may deconjugate
bilirubin diglucuronide , causing
pigment gallstones . -
pubmed
Our results indicate that several pH optima have to be taken into consideration in order to clarify the role of
human biliary
beta - glucuronidase in the pathogenesis of
pigment gallstones . -
pubmed
Bacterial beta - glucuronidase activity was associated with
duodenal diverticula ( p & lt ; 0.05 ) and
common duct stones ( p & lt ; 0.05 ) . -
pubmed
Active site - directed antibodies identify
calpain II as an early - appearing and pervasive component of neurofibrillary pathology in
Alzheimer ' s disease . -
pubmed
In
Alzheimer ' s disease (
AD ) , the activated form of
calpain I is significantly increased while the fate of
calpain II has been more difficult to address . -
pubmed
Here ,
calpain II antibodies raised to different sequences within a cryptic region around the active site , which becomes exposed during protease activation , were shown immunohistochemically to bind extensively to neurofibrillary tangles ( NFT ) , neuritic plaques , and neuropil threads in brains from
individuals with
AD . -
pubmed
Total levels of
calpain II remained constant in the prefrontal cortex of
AD patients but were increased 8 - fold in purified NFT relative to levels of
calpain I. -
pubmed
These results implicate activated
calpain II in
neurofibrillary degeneration , provide further evidence for the involvement of the calpain system in
AD pathogenesis , and imply that neuronal
calcium homeostasis is altered in
AD . -
pubmed
Mutations in the
Ret receptor tyrosine kinase are responsible for a variety of
human syndromes , including
multiple endocrine neoplasia 2 and
Hirschsprung ' s disease . -
pubmed
Assessment of
inflammation included accumulation of inflammatory cells in the lungs , lung weight , and protein and
LDH content of bronchial alveolar lavage fluid ( BALF ) . -
pubmed
Radiotherapy continues to have an important role in the treatment of
acromegaly and is particularly effective at halting
tumour growth , causing
tumour shrinkage and reducing
growth hormone ( GH ) concentrations in the long term . -
pubmed
The 24 hour
GH profile in active
acromegaly compared with normals , characteristically shows an increased frequency of
GH pulses , increased disorderliness ( approximate entropy ) of GH release , increased mean
GH valley nadir , increased non - pulsatile fraction of GH and either similar or increased
GH pulse amplitude . -
pubmed
Complete surgical excision of a
GH secreting
adenoma may reverse these abnormalities and reduce circulating
insulin - like growth factor-1 ( IGF-1 ) concentrations to normal . -
pubmed
However , very few data are available regarding the effects of radiotherapy on
GH pulsatility in
patients with
acromegaly . -
pubmed
The continuing effects of radiotherapy may potentially transform an
individual from a state of
GH excess , to a state of
GH deficiency , with as yet undetermined effects . -
pubmed
This may potentially alter
somatostatin ( SMS ) receptor expression on somatotroph
adenomas and alter their responsiveness to subsequent SMS analogue therapy . -
pubmed
Among the antagonists for putative
melatonin receptors studied , neither
luzindole (
melatonin MT1 and MT2 receptor antagonist ) nor
prazosin (
melatonin MT3 receptor antagonist ) antagonized the
melatonin reversal of
morphine tolerance and dependence . -
pubmed
Further , the
melatonin - induced reversal of
morphine tolerance and dependence is not mediated through its actions via putative
melatonin receptors . -
pubmed
CONCLUSIONS : In conclusion , both
collagen and ePTFE barriers proved suitable for achieving GBR of
osseous defects surrounding dental implants . -
pubmed
Effect of intensive lipid - lowering strategy on
low - density lipoprotein particle size in
patients with
type 2 diabetes mellitus . -
pubmed
A preponderance of small dense
LDL particles is strongly associated with the occurrence of
atherosclerotic disease . -
pubmed
Although several studies have documented an increased prevalence of small dense
LDL particles in
diabetes mellitus no data are available to show the effect of lipid - lowering treatment upon the improvement of
LDL particle size . -
pubmed
In the present study we examined the effect of lipid - lowering treatment , following an intensive lipid - lowering strategy for 30 weeks pursuing ADA recommended target lipid levels , on
LDL particle size in 50
type 2 diabetic patients with moderate
hyperlipidemia . -
pubmed
Although there are numerous mechanisms involved in the process of
renal disease progression , the
renin -
angiotensin system plays a major role as determined by the beneficial response to
angiotensin I - converting enzyme inhibitors ( ACEIs ) and
angiotensin II receptor blockers (
AT II blockers ) of reduced rate of progression in a variety of clinical and experimental
renal diseases . -
pubmed
Reversal of this abnormality and reduced stress on capillary walls may be the major mechanisms of beneficial action of ACEIs and
AT II blockers in halting
renal disease progression . -
pubmed
Increasing evidence has indicated that proinflammatory
cytokines such as
TNF - alpha and
IL-1beta , produced by activated microglia and astrocytes , play a key role in progressive degeneration of the nigrostriatal dopaminergic neurons in
Parkinson ' s disease (
PD ) . -
pubmed
Since
alpha - synuclein is a major component of Lewy bodies in
PD brains , we studied the constitutive and cytokine / neurotrophic factor - regulated expression of
alpha - synuclein in cultured
human neurons by Northern blot and Western blot analyses . -
pubmed
The levels of
alpha - synuclein expression were elevated markedly in
NTera2 teratocarcinoma cells following
retinoic acid - induced neuronal differentiation , accompanied with an increased expression of
synphilin-1 , while they were unaltered in
NTera2 - derived differentiated neurons by exposure to
TNF - alpha ,
IL-1beta ,
BDNF or
GDNF . -
pubmed
Effect of a
matrix metalloproteinase inhibitor on a lymph node metastatic model of
gastric cancer cells passaged by orthotopic implantation . -
pubmed
In this study , we investigated the effect of
R-94138 , a
matrix metalloproteinase (
MMP ) inhibitor , on the lymphnodal metastatic ability of
gastric cancer cells using an in vivo orthotopic implantation model in
nude mice . -
pubmed
These findings suggested that the
MMP inhibitor ,
R-94138 , could be used in adjunctive therapy for lymph node metastasis in
gastric carcinoma . -
pubmed
The
glutamate receptor system is implicated in the development and maintenance of
epileptic seizures , and
animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of
AMPA and / or kainate ( KA ) receptor activity . -
pubmed
In spite of promising anticonvulsant activity in various
animal model studies , no
AMPA / KA receptor inhibitors are in clinical use against
epilepsy today . -
pubmed
Future studies and development of such compounds will indicate whether
AMPA / KA receptor inhibition is a feasible therapeutic strategy for the treatment of
epilepsy . -
pubmed
Association of
interleukin-4 and
interleukin-1B gene variants with Larsen score progression in
rheumatoid arthritis . -
pubmed
OBJECTIVE : To perform a genetic association study using markers in the interleukin-1 ( IL-1 ) gene cluster and the
IL-4 / IL-4 receptor system genes , seeking evidence for involvement in the onset or the erosive outcome of
rheumatoid arthritis (
RA ) . -
pubmed
METHODS : We tested the allelic distribution of
IL-1A ( +4845 ) ,
IL-1B ( -511 ) ,
IL-1B ( +3954 ) ,
IL-1RN ( +2018 ) ,
IL-4 variable number of tandem repeat ( VNTR ) , and
IL-4R ( +1902 ) in 233
patients with
RA , 99 with
polymyalgia rheumatica , and 148 ethnically matched controls . -
pubmed
Among
RA patients , the rarer ( # 2 ) alleles of
IL-4 VNTR and
IL-1B ( -511 ) were both associated with a milder Larsen score progression : The slope of Larsen progression in the rare allele groups diverged significantly from those of the frequent allele groups after approximately 20 years of disease duration ( P & lt ; 0.001 ) . -
pubmed
The rarer alleles of
IL-4 VNTR and
IL-1B ( -511 ) appear to be associated with a less severe course in
RA of long duration . -
pubmed
Several lines of reasoning support the use of
angiotensin converting enzyme inhibitors or
angiotensin receptor blockers as the appropriate first - line therapy in
obese patients with uncomplicated
hypertension . -
pubmed
Clearly , further studies are needed to define target blood pressure levels in obese
patients and to clarify the value of established and newer drugs , like
angiotensin receptor blockers , for the treatment of obese
hypertensive patients . -
pubmed
Plasma
homocysteine and
lipoprotein ( a ) levels as risk factors for
atherosclerotic vascular disease in
epileptic children taking anticonvulsants . -
pubmed
AIM : To assess the effect of anticonvulsant treatment on plasma
homocysteine level and
lipoprotein ( a ) in
epileptic children . -
pubmed
METHODS : Plasma total
homocysteine ,
folate ,
vitamin B12 and
lipoprotein ( a ) concentrations were measured in 111
epilectic children taking anticonvulsant drugs for longer than 12 mo . -
pubmed
A significant inverse relationship was found between
vitamin B12 folate levels and plasma
homocysteine levels in the
patient group ; 28.8 % of the
patient group had
lipoprotein ( a ) concentrations above the cut - off value ( 30 mg / dl ) for increased risk of early
atherosclerosis , whereas none of the control
patients had concentrations above this value . -
pubmed
CONCLUSION : These data indicate that prolonged anticonvulsant treatment could increase plasma
homocysteine and
lipoprotein ( a ) concentrations and that it may be useful to measure the levels routinely in order to prevent
atherosclerosis in
epileptic children taking anticonvulsant drugs . -
pubmed
Cerebrospinal fluid examination during early stage revealed mild
leukocytic pleocytosis , elevation of protein and a high level of
IL-6 . -
pubmed
Mutant med
mice are
ataxic and lack expression of the
Scn8a gene , which encodes the
NaV1.6 protein . -
pubmed
Comparing the pathogenesis of experimental
autoimmune encephalomyelitis in
CD4-/- and CD8-/- DBA/1
mice defines qualitative roles of different T cell subsets . -
pubmed
Experimental
autoimmune encephalomyelitis (
EAE ) was induced with
myelin oligodendrocyte glycoprotein (
MOG ( 1 - 125 ) ) in
CD4(-/- ) and
CD8(-/- ) DBA/1
mice . -
pubmed
Both gene - deleted
mice developed clinical signs of
EAE , albeit milder than in wild - type
mice , suggesting that both
CD4(+ ) and
CD8(+ ) cells participate in disease development . -
pubmed
Demyelination and
inflammation in the central nervous system was reduced in the absence of
CD8(+ ) T cells . -
pubmed
Antibody depletion of CD4(+ ) cells completely protected
CD8(-/- )
mice from MOG - induced
EAE while depletion of
CD8(+ ) cells in
CD4 (-/- ) mice resulted in fewer
EAE incidence compared to that in control antibody - treated
mice . -
pubmed
Antibody depletion of
CD4(+ ) cells in wild - type
mice protected from
EAE , but not depletion of
CD8(+ ) cells , although demyelination was reduced on removal of
CD8(+ ) T cells . -
pubmed
Immunization with immunodominant
MOG(79 - 96 ) peptide led to
EAE only in the presence of
pertussis toxin ( PT ) in the inoculum . -
pubmed
PT also triggered an earlier onset and more severe
EAE in
CD8(-/- )
mice . -
pubmed
We interpret our findings such that in an ontogenic lack of
CD4(+ ) T cells ,
EAE is mediated by
CD8(+ ) and elevated levels of
alphabetaCD4(-)
CD8(- ) cells , and that
CNS damage is partly enacted by the activity of
CD8(+ ) T cells . -
pubmed
The dosage requirements for
mammalian TERT in telomere length homeostasis are not known , but are of importance in cellular senescence , stem cell renewal , and
cancer . -
pubmed
These studies reveal a unique dosage requirement for telomere length maintenance by
TERT ; despite haploinsufficiency for the maintenance of long telomeres ,
mTert+/-
mice retain minimal telomere DNA at all chromosome ends and do not exhibit the
infertility typical of
telomerase - deficient strains . -
pubmed
Unexpectedly ,
mTert+/-
mice are ersatz carriers for genetic instability , because their mating led to accelerated genetic instability and
infertility in null progeny . -
pubmed
Thus , limiting
TERT levels play a key role in the maintenance of genome integrity , with important ramifications for the maintenance of short telomeres in
human cancer and aging . -
pubmed
ECHs are speculated to originate from dermal dendritic subunits and are composed of 2 primary cell populations , ie ,
CD34 + primitive fibroblastic dendrocytes and
factor XIIIa+ histiocytes . -
pubmed
ECHs ' putative pathogenesis entails activation of
CD34 + " sentinel " reserve dendrocytes , followed by an influx of histiocytes and mast cells . -
pubmed
Development of spontaneous multisystem
autoimmune disease and
hypersensitivity to antibody - induced
inflammation in
Fcgamma receptor IIa - transgenic
mice . -
pubmed
Our aim was to determine the role of
FcgammaRIIa in a transgenic
mouse model of immune complex - mediated autoimmunity and to characterize the development of spontaneous
autoimmune disease . -
pubmed
METHODS :
Arthritis was induced in normal and
FcgammaRIIa - transgenic
mice by immunization with
type II collagen (
CII ) or by transfer of arthritogenic anti -
CII antibodies . -
pubmed
Also ,
mice that spontaneously developed
autoimmune disease were assessed by clinical scoring of affected limbs , histology and serology , and measurement of autoantibody titers and
cytokine production . -
pubmed
RESULTS :
FcgammaRIIa - transgenic
mice developed collagen - induced
arthritis (
CIA ) more rapidly than did archetypal CIA - sensitive DBA/1 ( H-2q )
mice , while nontransgenic C57BL/6 ( H-2b )
mice did not develop
CIA when similarly immunized . -
pubmed
Passive transfer of a single dose of anti -
CII antibody induced a more rapid , severe
arthritis in
FcgammaRIIa - transgenic
mice than in nontransgenic
animals . -
pubmed
Elevated
IgG2a levels were seen in
mice with
CIA and in those with spontaneous disease . -
pubmed
CONCLUSION : The presence of enhanced passive and induced
autoimmunity , as well as the emergence of spontaneous
autoimmune disease at 20 - 45 weeks of age , suggest that
FcgammaRIIa is a very important factor in the pathogenesis of
autoimmune inflammation and a possible target for therapeutic intervention . -
pubmed
Regular
insulin secretory oscillations despite impaired
ATP synthesis in
Friedreich Ataxia patients . -
pubmed
Friedreich Ataxia is an
inherited disorder caused by decreased expression of a mitochondrial protein called
frataxin . -
pubmed
In the present study
Friedreich Ataxia patients with a presumptive impairment of
ATP synthesis in pancreatic beta - cells were evaluated for regularity of basal secretory oscillations of
insulin . -
pubmed
P - gp expression has been reported in
chondrosarcoma and hypertrophic chondrocyte in the
human growth plate . -
pubmed
Histopathological examination revealed a
xanthogranulomatous lesion expressing
CD68 , but negative for
S100 protein ,
CD1a ,
CD3 , or
CD20 . -
pubmed
A morphological study of 200
atherosclerotic carotid sinus ( CS ) plaques obtained at carotid endarterectomy revealed the structural components and processes characteristic for severe
atherosclerosis ( foci of
atheromatosis and
edema ,
necrosis of
collagen and elastic fiber , newly formed vessels and
hemorrhages of various duration , lipophages and lymphocytes , portions of
fibrosis and
calcification , covering thinning and
ulceration ,
thrombi , and the contents of plagues ( atheromatous masses ,
cholesterol crystals , lipophages ,
calcificates ) on their surface ) . -
pubmed
We discuss a model that large body mass presents an increased
cancer risk , which drives the evolution of
telomerase suppression and replicative senescence . -
pubmed
The function of
folliculin (
Flcn ) , encoded by
BHD , is totally unknown , although its interaction with
Fnip1 has been reported . -
pubmed
These results suggest that
Flcn -
FnipL /
Fnip2 and
Flcn -
Fnip1 complexes positively regulate
S6K1 phosphorylation and that
FnipL /
Fnip2 provides an important clue to elucidating the function of
Flcn and the pathogenesis of
BHD . -
pubmed
Therapeutic effect of low - dose
IL-18 combined with
IL-10 on collagen - induced
arthritis by down - regulation of inflammatory and Th1 responses and induction of Th2 responses . -
pubmed
To investigate the anti - inflammatory or pleiotropic immunomodulatory role of
interleukin-18 (
IL-18 ) , collagen - induced
arthritis (
CIA )
mice were administrated with
IL-18 along or in combination with
IL-10 ,
IL-4 or
IL-12 . -
pubmed
Our results indicated that combined treatment of low - dose
IL-18 with
IL-10 can prevent the development of
CIA , which may be mediated not only by inhibiting Th1 responses through
IL-18 /
IL-18Ralpha signaling , but also by inducing
anti - inflammatory mediators through a
GATA-3 - dependent mechanism . -
pubmed
In tumor - bearing
mice , T cells conditioned with
B7 - H3 - blocked on
CD40 - activated apoptotic
tumor cell - pulsed DCs had a decreased ability to inhibit
tumor growth . -
pubmed
Therefore , it is hypothesized that high levels of
B7 - H3 expression contributes to the ability of
CD40 - activated
tumor associated DCs in eliciting efficient antitumor immune response , given this fact the potentially significant clinical implications ,
CD40 - activated DCs merit further considerations when preparing DCs for clinical application . -
pubmed
It is known that resistance to chemotherapy in
pancreatic cancer is associated with constitutively activated
nuclear factor - kappaB (
NF - kappaB ) , which becomes further activated by chemotherapeutic drugs . -
pubmed
Our data provide mechanistic evidence for the first time showing that
DIM potentiates the killing of
pancreatic cancer cells by down - regulation of constitutive as well as drug - induced activation of
NF - kappaB and its downstream genes (
Bcl - xL ,
XIAP ,
cIAP , and
survivin ) . -
pubmed
This was accompanied by loss of
phospho -
p65 and down - regulation of
NF - kappaB activity and its downstream genes (
Bcl - xL ,
survivin , and
XIAP ) , which correlated with reduced cell proliferation ( as assessed by
Ki-67 immunostaining of
tumor specimens ) and evidence of apoptosis [ as assessed by
poly ( ADP - ribose ) polymerase cleavage and terminal deoxynucleotidyl transferase - mediated
dUTP nick end labeling staining ] . -
pubmed
These results provide strong in vivo evidence in support of our hypothesis that
DIM could abrogate chemotherapeutic drug (
cisplatin ,
gemcitabine , and/or
oxaliplatin)-induced activation of
NF - kappaB , resulting in the chemosensitization of
pancreatic tumors to conventional therapeutics . -
pubmed
CDKs as therapeutic targets for the
human genetic disease tuberous sclerosis ? -
pubmed
Taken together , these findings strengthen the argument that besides
mTOR - inhibitors , such as
rapamycin analogues ,
p27 and
CDKs could also be considered targets for
hamartoma therapeutics in
tuberous sclerosis . -
pubmed
Increased
matrix metalloproteinase 9 activity in mild
cognitive impairment . -
pubmed
Nerve growth factor (
NGF)-dependent cholinergic basal forebrain neurons degenerate during the progression of
Alzheimer disease (
AD ) . -
pubmed
Elevated
proNGF and reduced levels of the
TrkA high - affinity
NGF receptor occur in prodromal and advanced stages of
AD . -
pubmed
The analysis demonstrated greater
MMP-9 activity in both
AD and mild
cognitive impairment compared with no
cognitive impairment brain samples ( p < 0.01 ) , which supports the notion that a metabolic failure in the
NGF - maturation / degradation pathway may be associated with an exacerbated degradation of
mNGF in the cerebral cortex in early
AD . -
pubmed
These findings suggest that a reduction in
mNGF as a consequence of
MMP-9 - mediated degradation may in part underlie the pathogenesis of
cognitive deficits in
mild cognitive impairment and
AD . -
pubmed
Memory B cells and plasma cells specific for the C - terminal region of
Merozoite Surface Protein 1 were detectable for more than eight months following
primary infection . -
pubmed
Polymorphisms in the
sialic acid - binding immunoglobulin - like lectin-8 (
Siglec-8 ) gene are associated with susceptibility to
asthma . -
pubmed
We investigated the genetic association between sequence variants in
Siglec-8 and diagnosis of
asthma , total levels of serum
IgE (
tIgE ) , and diagnosis of
eosinophilic esophagitis (
EE ) in diverse populations . -
pubmed
However , our association results suggest that the
Siglec8 gene may be a susceptibility locus for
asthma . -
pubmed
Tumor necrosis factor alpha as a marker of
systemic and local inflammation in " healthy " smokers . -
pubmed
We have not shown any significant relation between pulmonary function and the studied parameters , with only a modest association between forced expiratory volume at one second and forced vital capacity and
TNF - alpha levels in
EBC . -
pubmed
CONCLUSION :
Smokers show higher
TNF - alpha levels in
EBC . -
pubmed
We have shown a modest relation between pulmonary function and
TNF - alpha levels in
EBC . -
pubmed
Multivariate analyses pointed to
TL as an independent predictor in addition to serum pre - operative
PSA for reduced biochemical progression - free survival ( p=0.035 ) . -
pubmed
Chronic
alcohol - induced
liver injury and oxidant stress are decreased in
cytochrome P4502E1 knockout mice and restored in humanized
cytochrome P4502E1 knock - in
mice . -
pubmed
There is a need to develop oral models of significant
liver injury and to evaluate the possible role of
CYP2E1 in
ethanol actions in such models . -
pubmed
We evaluated chronic
ethanol - induced
liver injury ,
steatosis , and oxidant stress in wild - type ( WT )
mice ,
CYP2E1 knock out ( KO )
mice , and humanized
CYP2E1 knock - in ( KI )
mice , in which the
human 2E1 was added back to
mice deficient in the
mouse 2E1 . -
pubmed
Significant
liver injury was produced in the
ethanol - fed KI
mice , with elevated transaminases ,
necrosis , and increased levels of
collagen type 1 and
smooth muscle actin . -
pubmed
This
liver injury in the KI
mice was associated with elevated oxidant stress and elevated levels of the
human CYP2E1 compared to levels of the
mouse 2E1 in WT
mice . -
pubmed
Fatty liver in the WT and the KI
mice was associated with lower levels of
PPARalpha and
acyl - CoA oxidase . -
pubmed
These results show that
CYP2E1 plays a major role in
ethanol - induced
fatty liver and oxidant stress . -
pubmed
It is the absence of
CYP2E1 in the KO
mice that is responsible for the blunting of
steatosis and oxidant stress because restoring the
CYP2E1 restores the
fatty liver and oxidant stress . -
pubmed
Moreover , it is the
human CYP2E1 that restores these effects of
ethanol , which suggests that results for
fatty liver and oxidant stress from
rodent models of
ethanol intake and
mouse CYP2E1 can be extrapolated to
human models of
ethanol intake and to
human CYP2E1 . -
pubmed
Gene silencing of
myofibrillogenesis regulator-1 by adenovirus - delivered small interfering RNA suppresses
cardiac hypertrophy induced by
angiotensin II in
mice . -
pubmed
Our previous studies proved that
myofibrillogenesis regulator ( MR )- 1 has a close relationship with
cardiac hypertrophy induced by
ANG II . -
pubmed
In the present study , we developed a recombinant
adenoviral vector ( AdSiR - MR-1 ) driving small interfering ( si)RNA against
MR-1 to evaluate its effect on
cardiac hypertrophy in vivo . -
pubmed
Cardiac hypertrophy was induced by chronic
ANG II infusion in
mice ;
AdSiR - MR-1 was administered via the jugular vein through one bolus injection . -
pubmed
ANG II - induced
cardiac hypertrophy was suppressed in
mice treated with
AdSiR - MR-1 , as determined by echocardiography . -
pubmed
Morphological and immnohistochemical examinations revealed that interstitial cardiac
fibrosis as well as infiltrating inflammatory cells were increased after
ANG II infusion ;
AdSiR - MR-1 greatly ameliorated these disorders . -
pubmed
In
ANG II - infused
mice ,
MR-1 silencing also blocked the upregulation of other genes related to
cardiac hypertrophy or metabolism of the extracellular matrix . -
pubmed
In summary , our results demonstrate the feasibility of
MR-1 silencing in vivo and suggest that
MR-1 could be a potential new target to treat
cardiac hypertrophy induced by
ANG II . -
pubmed
Then clinical symptoms , and levels of body mass index ( BMI ) ,
obesity degree ,
alanine aminotransferase (
ALT ) ,
aspartate aminotransferase (
AST ) ,
gamma - glutamyl transpeptidase (
gamma - GT ) , total
cholesterol ( TC ) ,
triglyceride ( TG ) and CT ratio of liver and spleen before and after treatment were compared between two groups . -
pubmed
RESULTS : BMI ,
obesity degree and the levels of
ALT ,
AST , gamma - GT , TC , TG in the serum decreased more significantly in two groups after treatment ( all P<0.05 ) , and there were significant differences between two groups ( all P<0.05 ) , the catgut embedding group decreased more significantly . -
pubmed
Exon trapping analysis of c.301 - 19 G & gt ; A in intron 1 of the
SHH gene in a patient with a microform of
holoprosencephaly . -
pubmed
We identified a de novo nucleotide change , c.301 - 19 G & gt ; A , in intron 1 of
SHH in a four year old boy with a microform of
holoprosencephaly . -
pubmed
Chronological study of
cytokine transcription in the spleen and lung of
chickens after vaccination with serotype 1
Marek ' s disease vaccines . -
pubmed
Disruption of blastomeric
F - actin : a potential early biomarker of
developmental toxicity in
zebrafish . -
pubmed
In this review , we discuss the potential use of
F - actin disruption as a predictive biomarker of
developmental toxicity in
zebrafish . -
pubmed
HGAL protein expression uniformly correlated with GC B - cells in all except a subset of hyaline - vascular
CD that showed severe regression of GCs . -
pubmed
HGAL staining highlighted dismantled GCs in
PTGC , in contrast to weak or absent
CD10 and
BCL6 staining . -
pubmed
Highly sensitive
cardiac troponin - I in
congenital heart disease . -
pubmed
RESULT : Compared with the control group , the cognitive abilities ,
CAT activities , T - AOC and
Ach levels were decreased and
NO ,
MDA and
GLu contents were increased in
mice after
sleep deprivation for 72h . -
pubmed
Prognostic impact of
insulin receptor expression on survival of
patients with
nonsmall cell lung cancer . -
pubmed
BACKGROUND : The purpose of this study was to characterize
insulin receptor (
IR ) and
insulin - like growth factor-1 receptor (
IGF-1R ) expression in
patients with
nonsmall cell lung cancer (
NSCLC ) . -
pubmed
Expression of the
IR and
IGF-1R protein in
tumor specimens was assessed immunohistochemically using tissue microarrays . -
pubmed
RESULTS : The cytoplasmic
IR score was higher in
patients with
adenocarcinoma (
ADC ) than in those with
squamous cell carcinoma (
SCC ) , whereas cytoplasmic
IGF-1R score was higher in
patients with
SCC than those with ADC . -
pubmed
Finally , a multivariate analysis revealed the impact of
IR , but not of
IGF-1R , as an independent predictive marker of
NSCLC survival : hazard ratio ( HR ) for OS , 1.005 ( 95 % confidence interval [ CI ] , 1.001 - 1.010 ] , HR for RFS , 1.005 ( 95 % CI , 1.001 - 1.009 ) , when IR score was tested as a continuous variable . -
pubmed
CONCLUSIONS : Overexpression of
IR predicts a poor survival among
patients with
NSCLC , especially those with
SCC . -
pubmed
GIV (
Galpha - interacting vesicle - associated protein ; also known as
Girdin ) enhances
Akt activation downstream of multiple growth factor- and
G protein ( heterotrimeric guanosine 5 '- triphosphate - binding protein )- coupled receptors to trigger cell migration and
cancer invasion . -
pubmed
Tyrosine phosphorylation of
GIV and its association with
p85alpha increased during metastatic progression of a
breast carcinoma . -
pubmed
BACKGROUND : The aim of the study was to investigate variations in anti - infliximab (
IFX ) antibody ( Ab ) levels and clinical implications thereof in
patients with
inflammatory bowel disease (
IBD ) . -
pubmed
METHODS : A retrospective , explorative , single - center study of
patients with
IBD who developed
anti - IFX Ab and in whom
anti - IFX Ab were reassessed . -
pubmed
Immunoexpression of
claudin-1 and
Nm23 - H1 in metastatic and nonmetastatic lower
lip squamous - cell carcinoma . -
pubmed
The aim of this study was to evaluate the immunoexpression of
claudin-1 and
Nm23 - H1 in metastatic and nonmetastatic lower
lip squamous - cell carcinoma (
LLSCC ) . -
pubmed
The percentage of
claudin-1 staining and the staining intensity and percentage of
Nm23 - H1 staining in each
tumor core were assessed . -
pubmed
Metastatic
tumors exhibited higher expression of
claudin-1 than nonmetastatic
tumors ( P = 0.030 ) . -
pubmed
Similarly , stage III and IV
LLSCCs showed higher expression of
claudin-1 than stages I and II ( P = 0.026 ) . -
pubmed
The percentage of
claudin-1 staining was scored as 2 in most well - differentiated and moderately differentiated
tumors , whereas poorly differentiated
tumors showed a relatively similar distribution of scores 2 , 1 , and 0 ( P = 0.648 ) . -
pubmed
Regarding
Nm23 - H1 , there was a predominance of negative cases for both
metastatic and nonmetastatic
tumors ( P = 0.235 ) . -
pubmed
The results of this study suggest an important role of
claudin-1 in the development of metastasis in
LLSCCs . -
pubmed
In contrast , the present findings do not support a significant role of
Nm23 - H1 in metastasis suppression of
LLSCC . -
pubmed
Multiple endocrine neoplasia 2a ( MEN2a ) syndrome is one of the rare
genetic disorder where prophylactic thyroidectomy is recommended for
RET mutation carriers due to increased risk for developing
MTC during lifetime . -
pubmed
Association of
NAT2 phenotype with risk of
head and neck carcinoma : A meta - analysis . -
pubmed
Numerous studies have demonstrated that the polymorphisms of
NAT2 were correlated with individual susceptibility to several
malignant neoplasms , including
head and neck carcinomas (
HNC ) . -
pubmed
No significant associations between the rapid acetylator phenotype in
NAT2 and
HNC risk were found either in the overall analysis ( OR=0.98 ; 95 % CI 0.83 , 1.15 ; I(2)=57 % ; P(heterogeneity)=0.003 ) or in the subgroup analysis by ethnicity ( for the Caucasian population , OR=1.03 , 95 % CI 0.85 , 1.24 , I(2)=63 % , P(heterogeneity)=0.002 ; for other mixed populations , OR=0.78 , 95 % CI=0.61 , 1.00 , I(2)=0 % , P(heterogeneity)=0.47 ) . -
pubmed
In conclusion , this meta - analysis suggested that there is no association between the
NAT2 phenotype and the risk of
HNC . -
pubmed
In model systems , progressive
glomerular disease is associated with decreased
nephrin mRNA steady - state levels compared with
podocin mRNA . -
pubmed
Src kinase is a direct target of
apigenin against UVB - induced
skin inflammation . -
pubmed
Apigenin inhibited UVB - induced
cyclooxygenase-2 (
COX-2 ) expression , which is a well - known key mediator of
inflammation and
cancer , and restored the upstream stimulatory factor level in JB6 P+ cells . -
pubmed
Results using in vivo skin model indicate
apigenin significantly inhibits UVB - induced
ear edema development ,
COX-2 expression and
Src kinase activity in
SKH-1 hairless mice . -
pubmed
Collectively , these findings suggest that
apigenin exerts potent chemopreventive activity against UVB - induced
skin inflammation primarily by targeting
Src . -
pubmed
Nrf2 is not required for epithelial
prohibitin - dependent attenuation of experimental
colitis . -
pubmed
Expression of the mitochondrial protein
prohibitin (
PHB ) is also decreased during intestinal
inflammation . -
pubmed
Our previous study showed that genetic restoration of colonic epithelial
PHB expression [
villin - PHB transgenic ( PHB Tg ) mice ] attenuated dextran sodium sulfate ( DSS)-induced
colitis / oxidative stress and sustained expression of colonic
nuclear factor erythroid 2 - related factor 2 (
Nrf2 ) , a cytoprotective transcription factor . -
pubmed
This study investigated the role of
Nrf2 in mediating
PHB - induced protection against
colitis and expression of the antioxidant response element ( ARE)-regulated antioxidant genes
heme oxygenase-1 (
HO-1 ) and
NAD ( P ) H quinone oxidoreductase-1 (
NQO-1 ) . -
pubmed
PHB Tg ,
Nrf2(-/- ) , and
PHB Tg / Nrf2 (-/- ) mice were treated with DSS or
2,4,6 - trinitrobenzene sulfonic acid (
TNBS ) , and
inflammation and expression of
HO-1 and
NQO-1 were assessed . -
pubmed
PHB
Tg / Nrf2 (-/- ) mice mimicked PHB Tg
mice , with attenuated DSS- or TNBS - induced
colitis and induction of colonic
HO-1 and
NQO-1 expression , despite deletion of
Nrf2 . -
pubmed
PHB
Tg / Nrf2 (-/- ) mice exhibited increased activation of
ERK during
colitis . -
pubmed
Our results suggest that maintaining expression of intestinal epithelial cell
PHB , which is decreased during
colitis , reduces the severity of
inflammation and increases colonic levels of the antioxidants
HO-1 and
NQO-1 via a mechanism independent of
Nrf2 . -
pubmed
We previously found , in a
canine transferable
tumor model , that high concentration of
IL-6 produced by tumor - infiltrating lymphocytes effectively restores the
MHC expression of the
tumor cells and T - cell activation inhibited by tumor - derived
TGF - beta . -
pubmed
Epigenetic regulation of spinal
CXCR2 signaling in
incisional hypersensitivity in
mice . -
pubmed
Chemokine CC motif receptor 2 (
CXCR2 ) is a proinflammatory receptor implicated in
neuropathic and inflammatory pain and is known to be regulated by histone acetylation in some settings . -
pubmed
Blocking
CXCR2 reversed mechanical
hypersensitivity after hind paw incision . -
pubmed
In vitro activation of
hTERT - specific T cell responses in
lung cancer patients following chemotherapy . -
pubmed
OBJECTIVE : The aim of this study was to examine chemotherapy concomitant in vitro activation of
human telomerase reverse transcriptase (
hTERT)-specific T cell responses in peripheral blood mononuclear cell ( PBMC ) samples of
patients with advanced
non - small cell lung cancer (
NSCLC ) . -
pubmed
CONCLUSIONS : These results indicate , that concomitant to chemotherapy
hTERT - specific T cell responses can be activated in PBMC of
NSCLC patients in vitro . -
pubmed
Recent evidence supports the hypothesis that
tinnitus is related to
neuronal hyperactivity in auditory brain regions , and consequently drugs that increase GABAergic neurotransmission in the CNS , such as the
GABA ( B ) receptor agonist
L - baclofen , may be effective as a treatment . -
pubmed
Expression of
cellular retinoic acid - binding protein - I (
CRABP - I ) in the cerebrospinal fluid of adult onset
moyamoya disease and its association with clinical presentation and postoperative haemodynamic change . -
pubmed
OBJECTIVE : The elevation of
cellular retinoic acid - binding protein - I (
CRABP - I ) has been suggested as a candidate in the pathogenesis of paediatric
moyamoya disease (
MMD ) . -
pubmed
However , few studies have addressed
CRABP - I in adult onset
MMD . -
pubmed
The aim of this study was to examine the expression of
CRABP - I in the cerebrospinal fluid ( CSF ) of adult onset
MMD , and to evaluate its association with clinical presentation and postoperative haemodynamic change . -
pubmed
The differences in
CRABP - I expression according to disease entity ( unilateral
MMD vs bilateral
MMD vs
ACVD ) , initial presenting symptoms (
haemorrhage vs
ischaemia ) and postoperative haemodynamic change ( vascular reserve in single photon emission CT and basal collateral vessels in digital subtraction angiography ) were analysed . -
pubmed
RESULTS :
CRABP - I intensities in bilateral
MMD ( 1.45(0.86 - 2.52 ) ) were significantly higher than in unilateral
MMD ( 0.91(0.78 - 1.20 ) ) ( p=0.044 ) or
ACVD ( 0.85(0.66 - 1.11 ) ) ( p=0.004 ) . -
pubmed
CONCLUSIONS : Higher
CRABP - I in the CSF can be associated with typical bilateral
MMD pathogenesis in
adults . -
pubmed
Soluble
guanylyl cyclase (
sGC ) degradation and impairment of
nitric oxide - mediated responses in urethra from
obese mice : reversal by the
sGC activator
BAY 60 - 2770 . -
pubmed
This study investigated the USM relaxant machinery in
obese mice and whether soluble
guanylyl cyclase (
sGC ) activation with
BAY 60 - 2770 [ acid
4 -({( 4 - carboxybutyl ) [ 2 -( 5 - fluoro-2 -{[ 4 -( trifluoromethyl ) biphenyl-4 - yl ] methoxy } phenyl ) ethyl ] amino } methyl ) benzoic ] rescues the urethral reactivity through improvement of
sGC -
cGMP (
cyclic guanosine monophosphate ) signaling . -
pubmed
Reactive -
oxygen species ( ROS ) production was enhanced , but protein expression of
beta1 second guanylate cyclase subunit was reduced in USM from
obese mice , both of which were restored by
BAY 60 - 2770 treatment . -
pubmed
Long - acting
integrase inhibitor protects macaques from intrarectal
simian / human immunodeficiency virus . -
pubmed
Increased expression of
cytokines , soluble
cytokine receptors ,
soluble apoptosis ligand and apoptosis in
dengue . -
pubmed
In this study , the levels of
TNF - alpha ,
IL-6 ,
IL-1 ,
IL-17 , soluble
interleukin-1 receptor like 1 protein (
sST2 ) , soluble
TNF - related apoptosis - inducing ligand (
sTRAIL ) ,
IL-12 and soluble receptors for
TNF (
sTNF - RI and
sTNF - RII ) were determined by ELISA in
dengue patients and
monocyte / macrophage cultures . -
pubmed
CAV-1 contributes to
bladder cancer progression by inducing epithelial - to - mesenchymal transition . -
pubmed
CAV-1 has been shown to be an oncogene in
bladder cancer . -
pubmed
However , little is known about the relationship between
CAV-1 and EMT in
bladder cancer metastasis . -
pubmed
CAV-1 and
E - cadherin expression levels were measured and correlated with clinical features of
tumor grade and metastasis . -
pubmed
EMT was assessed in
bladder cancer cell lines (
T24 ,
UMUC3 ,
HT1376 , and
5637 ) using wound healing and in vitro transwell invasion assays , and small interfering RNA was used to knock down
CAV-1 and
Slug expression . -
pubmed
RESULTS : In this study , we show that increased
CAV-1 expression induces
bladder cancer cell migration and promotes the EMT , which was determined by the reduction of
E - cadherin expression and the induction of
N - cadherin and
vimentin expression . -
pubmed
Slug knockdown abolished the
CAV-1 - induced EMT in
bladder cancer cells . -
pubmed
In addition , positive
CAV-1 expression was significantly correlated with negative
E - cadherin expression , as determined by immunohistochemistry analysis in
bladder cancer tissues . -
pubmed
CONCLUSIONS : Our results suggest that
CAV-1 promotes invasive phenotypes in
bladder cancer cells by inducing EMT through up - regulation of
Slug expression , which occurs through activation of the
PI3K /
AKT signaling pathway . -
pubmed
This new role for
CAV-1 in promoting
bladder cancer metastasis presents
CAV-1 and related pathways as potential therapeutic targets in invasive
bladder cancer . -
pubmed
C3 activation status as expressed by the
C3c / native C3 ratio was 2.6 - fold higher ( p<0.01 ) in
subjects with
NASH despite reduced native
C3 concentrations ( 0.94 + -0.12 vs. 0.57 + -0.09 ; p<0.01 ) . -
pubmed
C3c ,
C3 activation status (
C3c / C3 ratio ) and
properdin levels increased with higher lobular
inflammation scores as determined according to the Kleiner classification (
C3c : p<0.01 ,
C3c / C3 ratio : p<0.05 ,
properdin : p<0.05 ) . -
pubmed
Hepatic mRNA expression of
factor B and
factor D did not differ between subjects with healthy livers and subjects with
NASH (
factor B : 1.00 + -0.19 vs. 0.71 + -0.07 , p = 0.26 ;
factor D : 1.00 + -0.21 vs. 0.66 + -0.14 , p = 0.29 ;) . -
pubmed
Hepatic mRNA and protein levels of
Decay Accelerating Factor tended to be increased in subjects with
NASH ( mRNA : 1.00 + -0.14 vs. 2.37 + -0.72 ; p = 0.22 ; protein : 0.51 + -0.11 vs. 1.97 + -0.67 ; p = 0.28 ) . -
pubmed
In contrast ,
factor H mRNA was downregulated in
patients with
NASH ( 1.00 + -0.09 vs. 0.71 + -0.06 ; p<0.05 ) and a similar trend was observed with hepatic protein levels ( 1.12 + -0.16 vs. 0.78 + -0.07 ; p = 0.08 ) . -
pubmed
RT - qPCR measurement on the expressions of key transcriptional regulators in cardiogenesis showed that
BMP4 ,
NKX2 - 5 , and
TBX5 were significantly inhibited at the exposure points of 12 hpf and 24 hpf which may be the internal factors related to the
heart developmental toxicity . -
pubmed
The principal objective of the current study is to determine the outcomes and clinical management of
hyperglycemia in pregnancies complicated by
glucokinase gene (
GCK ) and
hepatocyte nuclear factor ( HNF )- 1alpha MODY mutations . -
pubmed
Seven - point home blood
glucose monitoring over a 7 - day period in each trimester demonstrated higher fasting and postprandial glycemic excursions in the first trimester of
GCK pregnancies when compared to
HNF-1alpha pregnancies ( fasting 104 [ 90 - 115 ] mg / dL vs 84 [ 77 - 88 ] mg / dL ; P = .01 and postprandial 154 [ 135 - 196 ] mg / dL vs 111 [ 100 - 131 ] mg / dL ; P = .04 ) despite
insulin treatment . -
pubmed
There was a higher percentage of miscarriages in the GCK group when compared to the
HNF-1alpha MODY group ( 33.3 % vs 14 % ; P = .07 ) , which was similar to the background population . -
pubmed
Insulin initiated at an early gestation appeared to lower the incidence of
macrosomia in GCK unaffected offspring . -
pubmed
CONCLUSION :
Hyperglycemia in
HNF-1alpha pregnancies is easily managed with current
insulin protocols ; in contrast , glycemic excursions are difficult to manage in
GCK pregnancies . -
pubmed
Retinol binding protein 4 plasma level in
myelodysplastic syndrome subgroups . -
pubmed
Loss - of - function mutation in
ABCA1 and risk of
Alzheimer ' s disease and
cerebrovascular disease . -
pubmed
METHODS : We tested whether a loss - of - function mutation in
ABCA1 , N1800H , is associated with plasma levels of
apoE and with risk of
Alzheimer ' s disease (
AD ) in 92,726
individuals and with risk of
cerebrovascular disease in 64,181
individuals . -
pubmed
DISCUSSION : A loss - of - function mutation in
ABCA1 , present in 1:500
individuals , was associated with low plasma levels of
apoE and with high risk of
AD and
cerebrovascular disease in the general population . -
pubmed
BACKGROUND :
Spinocerebellar Ataxia Type 3 /
Machado - Joseph Disease (
SCA3 /
MJD ) is a
hereditary neurodegenerative disorder resulting from the expansion of CAG repeats in the
ATXN3 gene . -
pubmed
We undertook a national study in order to characterize the
ATXN3 gene and to determine the prevalence of
SCA3 /
MJD in Cuba . -
pubmed
OBJECTIVE : The aim of this study was to compare hair thyroid hormone (
TH ) levels among first - episode
patients with
major depressive disorder (
F - MDD ) , recurrent
patients with
major depressive disorder (
R - MDD ) and healthy controls ( HC ) . -
pubmed
CONCLUSIONS : Our findings suggested that disease duration of recurring episodes of
depression may influence hair
TH levels . -
pubmed
Effectiveness and Feasibility Associated with Switching to a Second or Third
TNF Inhibitor in
Patients with
Psoriatic Arthritis : A Cohort Study from Southern Sweden . -
pubmed
OBJECTIVE : Because new modes of action for the treatment of
psoriatic arthritis (
PsA ) are emerging , it is important to understand the use of switching to a second or third antitumor necrosis factor ( anti -
TNF ) agent . -
pubmed
This study investigated drug survival and treatment response rates of
patients with
PsA undergoing second- and third - line anti -
TNF therapy . -
pubmed
The mechanisms of reduced
ERGF in
obese kidney donors are still poorly understood . -
pubmed
CAR treatment lowered high
serum transaminase activities together with hepatic histopathologic improvements in
rats with
ASH . -
pubmed
Our results indicate that
CAR may be effective in suppressing proinflammatory , prooxidant , and profibrotic factors in the liver of
rats with
ASH . -
pubmed
Inhibitory effect of traditional oriental medicine - derived
monoamine oxidase B inhibitor on radioresistance of
non - small cell lung cancer . -
pubmed
In the present study ,
danshensu which is a selected component of traditional oriental medicine ( TOM ) compound was found to reduce the radioresistance of
NSCLC by inhibiting the
nuclear factor - kappaB (
NF - kappaB ) pathway . -
pubmed
Danshensu decreased the activation of
NF - kappaB by inhibiting
MAOB activity in
A549 and
NCI - H1299 NSCLC cells . -
pubmed
Taken together , this study shows that
danshensu significantly reduces
MAOB activity and attenuates
NF - kappaB signaling to elicit the radiosensitization of
NSCLC . -
pubmed
Serum
Hepcidin Levels in Childhood - Onset
Ischemic Stroke : A Case - Control Study . -
pubmed
Despite the growing evidence of
iron imbalance in childhood - onset
ischemic stroke , serum
hepcidin level in those
patients has not yet been researched . -
pubmed
In this study , we aimed to estimate serum (
hepcidin ) level in
acute ischemic stroke (
AIS )
patients and to investigate whether subcutaneous
enoxaparin sodium , which is a low - molecular - weight
heparin ( LMWH ) derivative , could modulate serum
hepcidin level in those
patients . -
pubmed
The
patients were subdivided according to treatment with an LMWH derivative into 2 groups and serum
hepcidin levels were assessed initially and 1 week after
stroke onset for all cases . -
pubmed
We found that
AIS cases had higher serum
iron ,
ferritin , and
IL6 levels compared to the control group ( all P & lt ; 0.01 ) . -
pubmed
Serum
hepcidin was significantly higher in
AIS cases ( median , 36[15 - 73]ng / mL ) compared to the control group ( median , 24[10 - 41]ng / mL ; P & lt ; 0.01 ) . -
pubmed
On the 1st day of
AIS diagnosis , serum
hepcidin levels were similar in both
stroke subgroups ( P & gt ; 0.05 ) . -
pubmed
However , on the 7th day of diagnosis serum
hepcidin level decreased significantly in
AIS cases treated with LMWH ( group 1 ) ( median , 36 vs 21 ng / mL ; P & lt ; 0.01 , respectively ) . -
pubmed
Meanwhile , no significant change was observed in serum
hepcidin level in
AIS cases not treated with LMWH ( group 2 ) ( P & gt ; 0.05 ) . -
pubmed
Our data brought a novel observation of elevated serum
hepcidin level in pediatric
AIS patients and pointed out that treatment with
LMWH could modulate
hepcidin level in those
patients . -
pubmed
Bone health assessment by quantitative ultrasound and dual - energy x - ray absorptiometry in postmenopausal
women with
breast cancer receiving
aromatase inhibitors . -
pubmed
The aim of the present study was to assess bone status by phalangeal QUS and by dual - energy x - ray absorptiometry ( DXA ) , and to evaluate bone turnover in
breast cancer (
BC )
women receiving
aromatase inhibitors ( AIs ) . -
pubmed
AD - SoS was associated with change of BMD at lumbar spine ( beta , 0.16 ; SE , 0.08 ; P = 0.04 ) and change of
BSAP ( beta , -0.04 ; SE , 0.02 ; P = 0.04 ) . -
pubmed
Increased epidermal innervation and production of
neurotrophins , neuropeptides ,
cytokines and
proteases , in addition to their relations with the sensory receptors in an epidermis with poor lipid mantle , are the aspects currently covered for understanding
atopic dermatitis . -
pubmed
Exploiting
histone deacetylases for
cancer therapy : from
hematological malignancies to
solid tumors . -
pubmed
Hypertrophy and osteogenic differentiation events were also activated by production of
TGF - beta via rAAV , suggesting that translation of the current approach in vivo will probably require close regulation of expression of this candidate gene . -
pubmed
High - mobility group box protein 1 expression in
inflammatory diseases of the middle ear . -
pubmed
High - mobility group box 1 (
HMGB1 ) is a nuclear non - histone protein , playing a critical role as a mediator between innate and acquired immunity ; when released extracellularly , it coordinates the cellular stress response ( under
necrosis , bacterial lipopolysaccharide stimulation ) and acts as an inflammatory marker and
cytokine . -
pubmed
The aim of the study was to demonstrate whether
HMGB1 is over - expressed in chronic
middle - ear pathologies and whether the entity of expression and the localization are correlated with the degree of the inflammatory reaction , thus suggesting that
HMGB1 may play a crucial role in
chronic inflammatory disorders of the middle ear , as already demonstrated in other
airway diseases . -
pubmed
A statistically significant difference in inflammation score between
otosclerosis and chronic
otitis samples ( P & lt ; 0.01 ; Anova test ) and between
otosclerosis and
cholesteatoma samples ( P & lt ; 0.05 ; Anova test ) was observed ; the
HMGB1 positivity was in accordance with the density of the inflammatory infiltrate . -
pubmed
HMGB1 is over - expressed in chronic middle - ear pathologies and may play a role in the progression of the inflammatory process from recurrent
acute otitis media to
chronic suppurative otitis media . -
pubmed
CCL11 concentration increases dramatically in
schizophrenia ,
Alzheimer ' s disease ,
neuro - inflammatory disorders ,
cerebral malaria ,
drug addiction , as well as in
atherosclerosis ,
periodontal disease ,
macular degeneration ,
cancer and other pathologies . -
pubmed
In contrast to
CCL11 ,
differentiation growth factor 11 (
GDF11 ) , being administered to old
mice , eliminates age - associated
hypertrophy of the heart , improves muscle tone and prevents degenerative changes in the CNS , improves cognitive functions and enhances tissue regeneration . -
pubmed
At the same time , the higher the
GDF11 level in the blood , the milder
myocardial infarction ,
stroke and other age - related
diseases of the cardiovascular system . -
pubmed
Prevalence and significance of
HBeAg and isolated anti -
HBc in several institutions for the
mentally retarded in the autonomous community of madrid . -
pubmed
Hepatitis B virus ( HBV ) surface antigen (
HBsAg ) and antibody to
HBsAg (
antiHBs ) are excellent markers for
HBV infection and its immunity . -
pubmed
Proportionately more
Down syndrome chronic carriers of
HBsAg acquired the persistent
Hepatitis Be antigen (
HBeAg ) than
non - Down syndrome patients 15 ( 65.2 % ) vs. 1 ( 20 % ) . -
pubmed
The presence of
HBeAg was correlated with
abnormal liver function and high titres of
HBsAg . -
pubmed
Testing for the
IgM antibody to the
hepatitis B core antigen (
IgM AntiHBc ) facilitated the identification of
acute and chronic hepatitis infection in both RI and NRC individuals . -
pubmed
It is not certain whether the isolated
antiHBc seropositivity represents chronic " low levels " of
HBV , past
infection , or false - positive tests , and whether this test should be employed as a vaccine screening test . -
pubmed
Treatment of
BCR -
ABL+
human leukemia has been significantly improved by
ABL tyrosine kinase inhibitors ( TKIs ) , but they are not curative for most
patients and relapses are frequently associated with
BCR -
ABL mutations , warranting new targets for improved treatments . -
pubmed
We have now demonstrated that protein expression of
human estrogen receptor alpha 36 (
ERalpha36 ) , an alternative splicing variant of
human estrogen receptor alpha 66 (
ERalpha66 ) , is highly increased in TKI - insensitive
CD34 +
chronic myeloid leukemia (
CML ) cells and
BCR -
ABL - T315I mutant cells , and is abnormally localized in plasma membrane and cytoplasm . -
pubmed
Adhesion G protein - coupled receptors (
aGPCRs ) play critical roles in diverse biological processes , including neurodevelopment and
cancer progression . -
pubmed
Association of
CDKAL1 nucleotide variants with the risk of
non - syndromic cleft lip with or without
cleft palate . -
pubmed
This study provides the first evidence that chromosomal region 6p22.3 is a novel susceptibility locus for
nsCL / P. The location of the risk variants within the
CDKAL1 intronic sequence containing enhancer elements predicted to regulate the
SOX4 transcription may suggest that
SOX4 , rather than
CDKAL1 , is a potential candidate gene for this
craniofacial anomaly . -
pubmed
These initial local haemodynamic disturbances may trigger
fibrin deposition and
thrombosis . -
pubmed
Both modes of
infection require the
viral glycoprotein Envelope (
Env ) . -
pubmed
Vitamin B12 modulates
Parkinson ' s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection . -
pubmed
Missense mutations in
Leucine - Rich Repeat Kinase 2 (
LRRK2 ) cause the majority of familial and some sporadic forms of
Parkinson ' s disease (
PD ) . -
pubmed
The hyperactivity of
LRRK2 kinase induced by the pathogenic mutations underlies
neurotoxicity , promoting the development of
LRRK2 kinase inhibitors as therapeutics . -
pubmed
Treatment with
AdoCbl inhibits
LRRK2 kinase activity in
cultured cells and brain tissue , and prevents
neurotoxicity in cultured primary
rodent neurons as well as in transgenic
C. - pubmed
Ewing ' s sarcomas are characterized by a
CD99 positivity in immunohistochemistry stain and a t(11:22)(q24 : q12 ) translocation in cytogenetic study . -
pubmed
The Dephosphorylation of
p70S6 (
Thr389 ) Kinase as a Marker of
L - Glutamate - Induced
Excitotoxicity Related to
Diabetes Disturbances - an Unconventional In Vitro Model . -
pubmed
It is connected with
diabetic disturbance , and it is still being analyzed in the context of the participation of the
PI3K /
mTOR pathway . -
pubmed
A very important protein belonging to this pathway is
p70S6 K , whose activation promotes the pathogenesis of
type 2 diabetes by the induction of
insulin resistance . -
pubmed
The three reagents were used in different concentrations to create the model of excitotoxicity related to
diabetes disturbances :
L - glutamate ( 2.5 mM ; 10 mM ) ,
glucose ( 150 mM ; 200 mM ) , and
insulin ( 0.093 mM ; 0.371 mM ) . -
pubmed
The aim of our study was to examine and evaluate the levels of phosphorylation of proteins involved in signal transduction controlled by
MAPK ,
PI3K /
Akt , and
mTOR signaling pathways in
L - glutamate - induced
excitotoxicity with comorbid
hyperglycemia and
hyperinsulinemia imitating
diabetic disturbances in in vitro conditions on
PC12 cells . -
pubmed
This confirms the inhibition of
mTOR kinase and suggests that
p70S6 K (
Thr389 ) plays a functional role in the regulation of the signaling pathway in excitotoxicity related to
diabetic disturbances . -
pubmed
Aging ; increased blood
glucose , serum
uric acid and white blood cells ; decreased serum pH and
albumin ;
coma ; and preexisting
chronic kidney disease (
CKD ) were risk factors of
AKI in
patients with
DKA . -
pubmed
Shh Overexpression Is Correlated with
GRP78 and
AR Expression in
Primary Prostate Cancer : Clinicopathological Features and Outcomes in a Chinese Cohort . -
pubmed
Introduction :
Shh plays an important role in
prostate cancer progression , but its correlation with
GRP78 and
AR is elusive . -
pubmed
We performed immunohistochemistry to evaluate the expression of the
Shh protein in
benign prostatic hyperplasia ( n=96 ) and
prostate cancer ( Gleason scores < = 6 [ n=399 ] or > = 7 [ n=44 ] ) . -
pubmed
Results :
Shh expression was significantly higher in
prostate cancer with Gleason scores > = 7 than in
cancer with lower Gleason scores or benign
hyperplasia and was much higher in
AR - positive cancer than in
AR - negative cancer . -
pubmed
Shh is overexpressed in
high - grade prostate cancer and is positively correlated with the expression of both
GRP78 and
AR . -
pubmed
Conclusion : Therefore ,
Shh may be a useful prognostic marker and therapeutic target for
prostate cancer . -
pubmed
Results : Compared with the CUMS group , CSS and coadministration of CSS and
FLU could alleviate the
depressive symptoms and improve cognitive function in CUMS
rats ( p < 0.05 ) ; CSS and coadministration of CSS and
FLU could increase the expression of
BDNF , p - CREB /
CREB , p - ERK /
ERK , and
BDNF mRNA , CREB mRNA , and
ERK mRNA in the hippocampus and frontal cortex ( p < 0.05 ) ; CSS and coadministration of CSS and
FLU could increase the expression of
BDNF , p - CREB /
CREB , p - ERK /
ERK , and
BDNF mRNA , CREB mRNA , and
ERK mRNA in the hippocampus and frontal cortex ( p < 0.05 ) ; CSS and coadministration of CSS and
FLU could increase the expression of
BDNF , p - CREB /
CREB , p - ERK /
ERK , and
BDNF mRNA , CREB mRNA , and
ERK mRNA in the hippocampus and frontal cortex ( Discussion and Conclusion . -
pubmed
Inflammatory responses mediated by the
transcription factor nuclear factor kappa - light - chain enhancer of activated B cells (
NF - kappaB ) play key roles in immunity ,
autoimmune diseases , and
cancer . -
pubmed
RESULTS : Ten of 14 ( 71.4 % )
MCs exhibited clinically significant variants , including
KRAS ,
GNAS , and
TP53 . -
pubmed
Ten of 15 ( 66.7 % )
PDACs had
KRAS alterations , and 9 of 15 ( 60 % ) showed variants in
TP53 . -
pubmed
CONCLUSION : These data indicate that the CeA
GABAa receptors play a key role in the regulation of the compulsive
cocaine - seeking behavior and suggest that an increase in the function of the
GABAa receptors possibly induced by
cocaine or genetic factors may be an important mechanism involved in the development of or vulnerability to the compulsive
cocaine use and
addiction . -
pubmed
Choice of Differentiation Media Significantly Impacts Cell Lineage and Response to
CFTR Modulators in Fully Differentiated Primary Cultures of
Cystic Fibrosis Human Airway Epithelial Cells . -
pubmed
Physiological assays ( intracellular / extracellular pH , Ussing chamber ) specifically showed that
ATP12A and
CFTR function were altered , impacting pH and transepithelial ion transport in
CF hAECs . -
pubmed
Butyrylcholinesterase ( BChE ) deficiency is characterized by prolonged
apnea after the use of muscle relaxants (
suxamethonium or
mivacurium ) in
patients who have mutations in the
BCHE gene . -
pubmed
Expression of recombinant
BCHE mutants , kinetic analysis and molecular dynamics were undertaken to understand how these mutations induce
BChE deficiency . -
pubmed
A Progressive Loss of phosphoSer138 -
Profilin Aligns with Symptomatic Course in the R6/2
Mouse Model of
Huntington ' s Disease : Possible Sex - Dependent Signaling . -
pubmed
The R6/2 transgenic
mouse model of
Huntington ' s disease (
HD ) carries several copies of exon1 of the
huntingtin gene that contains a highly pathogenic 120 CAG - repeat expansion . -
pubmed
The translational potential of these observations was inferred from preliminary observations of changes in
LIMK -
cofilin signaling and loss of neurite integrity in neural stem cells derived from an
HD patient ( versus a healthy control ) . -
pubmed
Our observations suggest that a pre - symptomatic , neurodevelopmental onset of change in the phosphorylation of
Ser138 -
profilin , potentially downstream of distinct signaling changes in male and female
mice , could be contributing to cytoskeletal phenotypes in the R6/2
mouse model of
HD pathology . -
pubmed
The mechanisms of action for MSC - based
cancer treatment include the expression of " suicide genes , " induction of
tumor cell apoptosis , and delivery of
cytokines to induce an immune response against
cancer cells . -
pubmed
[ Effect of
thyrocalcitonin on the course of
postradiation lesions of the jaw bones ] . -
pubmed
Effects of
zinc sulfate on
Pseudomonas aeruginosa infections and
protease in
rabbit corneas . -
pubmed
Taken together these results suggest that although the
okadaic acid class of
tumor promoters and
phorbol ester - related agents bind to two different cellular receptors having counteracting enzymic activities , they share a common mechanism of action , namely the induction of cytosol to membrane translocation of
PKC . -
pubmed
[ Recombinant
erythropoietin -- a fundamental change in the treatment of
anemia ? ] -
pubmed
The authors summarize in the submitted review recent findings on
erythropoietin (
EPO ) and recombinant
EPO (
rHuEPO ) , a new therapeutic preparation which changed fundamentally the clinical picture of many diseases associated with
anaemia . -
pubmed
The authors discuss the physiology of
EPO , regulation of its secretion , mechanism of action on bone marrow and its importance in the pathogenesis of
polycythaemia and in particular
anaemia . -
pubmed
They emphasize in particular the use of
rHuEPO in the treatment of different forms of
anaemia . -
pubmed
They analyze the pathogenesis of
renal anaemia and the importance of treatment with
rHuEPO for improvement of the haemogram as well as the general condition of the
patients , their adaptability , improved psychic condition and reduced need of transfusions . -
pubmed
The authors draw attention to the great importance of treatment with
rHuEPO in the treatment of
anaemias associated with
inflammatory diseases (
rheumatoid arthritis ,
AIDS ,
Crohn ' s disease and others ) ,
anaemia associated with
malignancies , in the treatment of
surgical diseases and in autotransfusions , in
anaemias of premature infants and in some
congenital heart diseases . -
pubmed
The introduction of
rHuEPO into the treatment of
anaemia is a great advance of modern pharmacotherapy , which moreover opened new vistas on the role of
anaemia in the clinical picture of many diseases . -
pubmed
A model of
prostatic carcinoma tumor kinetics based on
prostate specific antigen levels after radiation therapy . -
pubmed
Serial
prostatic specific antigen values (
PSA ) were determined on 42
patients receiving definitive radiation therapy for localized
adenocarcinoma of the prostate . -
pubmed
The
PSA values after radiation therapy were employed to formulate a model of
tumor kinetics . -
pubmed
Focal
cerebral infarction in
cats in the presence of
hyperglycemia and increased
insulin . -
pubmed
We hypothesized that other factors associated with
hyperglycemia , such as plasma
insulin , may alter the brain 's response to
hyperglycemia . -
pubmed
The objective of this study was to determine if
hyperglycemia changes
infarction size following 8 hr of
middle cerebral artery occlusion in the anesthetized
cat and to examine if changes in plasma
insulin levels alter
hyperglycemia 's effects . -
pubmed
Infarct size in
hyperglycemic cats with increased plasma
insulin ( 38.3 + /- 8.4 , mean + /- SE ) or in
hyperglycemic cats without increased plasma
insulin ( 30.5 + /- 7.6 % ) was not significantly different from that of
ischemic controls ( 33.8 + /- 2.8 % ) . -
pubmed
Glial fibrillary acidic protein in Muller cells has previously been shown to increase after
retinal detachment ; here we show that
vimentin , another intermediate filament protein present in Muller cells , also increases after detachment . -
pubmed
crassiceps induced higher
IgG2a than
IgG1 levels and 10 - fold lower
IgE levels than the natural ip
infection ; however , despite the greater
IgG2a polyclonal response ,
anti - parasite antibodies were predominantly of the
IgG1 subclass . -
pubmed
Evolution of plasma specific
fibrin degradation products during thrombolytic therapy in
patients with
thrombo - embolism . -
pubmed
The author is of the opinion that the
renin -
angiotensin -
aldosterone system might be related to these changes during
respiratory acidosis . -
pubmed
Recently , Fujii and Morita have reported that an increase in
plasma renin activity appeared during acute
respiratory acidosis . -
pubmed
These reports prompted me to question whether the
renin -
angiotensin -
aldosterone system was related to the pathophysiological evidence concerning the
respiratory acidosis . -
pubmed
Therefore , the purpose of this experiment was to investigate the roles of the
renin - angiotensin system and electrolyte metabolism on plasma
aldosterone concentration during acute
respiratory acidosis . -
pubmed
I initiated acute
respiratory acidosis with 10 %
CO2 inhalation in healthy
mongrel dogs , and then plasma
aldosterone concentration ,
plasma renin activity , electrolytes and cardiorenal hemodynamics were measured . -
pubmed
The increase of plasma
aldosterone concentration was delayed and blurred , in contrast with a significant increase of
plasma renin activity , during the acute
respiratory acidosis , due to delayed time course of
angiotensin II stimulation and also the expected changes in the concentration of
angiotensin II receptors on the zona glomerulosa in the adrenal cortex . -
pubmed
There was a possibility that the increase in the reabsorption of
sodium and water in the proximal tubules , and the increase of
ADH secretion during the acute
respiratory acidosis , could be related to a decrease in excreted
sodium and
potassium as well as urine volume . -
pubmed
These results suggest that the changes of plasma
aldosterone concentration may be affected partially by
renin -
angiotensin system but not by serum
potassium , and plasma
aldosterone should be a minimal determinant on the electrolyte metabolism during
respiratory acidosis with 10 %
CO2 inhalation . -
pubmed
( iii ) Infected nu / nu
mice produced
IgM antibody only transiently in the early stage of
infection but they did not subsequently show regular
IgG antibody production which normally occurred in nu/+
mice . -
pubmed
The overall structure of
p40 is homologous to that of the
mouse Mov-34 gene product , whose gene disruption by proviral integration results in a recessive
embryonic lethality . -
pubmed
With both types of lymphocytes , the
cytotoxicity was partially inhibited by a preincubation of the effector cells with
anti - gamma delta antibodies . -
pubmed
These results demonstrate that gamma delta lymphocytes can mediate anti - tumour
cytotoxicity and
NS8 lymphoma line may be representative of the
TCR gamma delta CD8 + T cell subpopulation expressing non
MHC - restricted
cytotoxicity and displaying antitumoral activity . -
pubmed
The viral oncogene ,
v - rel , is a truncated and mutated form of the
turkey c - rel gene expressed by
reticuloendotheliosis virus , strain T. In this study , we demonstrated that three avian immunoregulatory receptors ,
major histocompatibility ( MHC ) antigens class I and class II as well as the
interleukin-2 receptor (
IL-2R ) , were induced on the surface of splenic
tumor cells isolated from
chickens infected with
reticuloendotheliosis virus , strain T. All
cell lines derived from
splenic tumors expressed these three proteins . -
pubmed
We show that
v - rel induced the expression of
MHC class II in the
avian B - cell lines DT40 and
DT95 more rapidly than
c - rel and that , several weeks after
infection ,
v - rel induced
MHC class II as much as 50 - fold more efficiently than
c - rel . -
pubmed
These data suggest that during
tumor development ,
v - rel functions to induce ( or suppress ) the expression of genes similarly induced ( or suppressed ) by
c - rel . -
pubmed
The observations reported in this study are not in agreement with a model in which
v - rel promotes
tumor development by functioning as a
dominant negative mutant of
c - rel . -
pubmed
In contrast , these findings support the hypothesis that lymphocyte immortalization and
tumor development are the result , at least in part , of the capacity of
v - rel to function as a dominant positive mutant that induces expression of genes normally regulated by
c - rel . -
pubmed
In the 20 yr since it was established that impairment of
dihydrotestosterone formation is the cause of a rare form of
human intersex , a wealth of information has accumulated about the genetics , endocrinology , and variable phenotypic manifestations , culminating in the cloning of cDNAs encoding two
5 alpha - reductase genes and documentation that mutations in the
steroid 5 alpha - reductase 2 gene are the cause of
5 alpha - reductase deficiency . -
pubmed
It is also imperative to establish whether defects in
steroid 5 alpha - reductase 2 , perhaps in the heterozygous state , are responsible for a portion of cases of
sporadic hypospadias , to determine whether
5 alpha - reductase plays a role in
progesterone action in
women , and to elucidate the relation between
androgen action and gender role behavior . -
pubmed
Differential expression of
basic fibroblast growth factor (
bFGF ) in
melanocytic lesions demonstrated by in situ hybridization . -
pubmed
Basic fibroblast growth factor (
bFGF ) is an angiogenic and mitogenic polypeptide produced by diverse cell types including cell lines derived from
malignant melanomas but not from normal melanocytes . -
pubmed
However , there is no consensus concerning in vivo expression of
bFGF in
melanocytic lesions due in part to the small numbers of cases studied to date . -
pubmed
To evaluate further the possible differential expression of
bFGF in
melanocytic lesions , we examined 110
formalin - fixed , paraffin - embedded metastatic and primary
invasive melanomas ,
melanomas in situ ,
nevi with
architectural disorder and
cytological atypia , and ordinary benign
melanocyte nevi by nucleic acid in situ hybridization . -
pubmed
All metastatic and primary invasive
melanomas studied expressed
bFGF mRNA , whereas
melanomas in situ and benign
melanocyte nevi were negative . -
pubmed
Melanomas in situ with features of
tumor regression and a majority of
nevi with
architectural disorder and
cytological atypia also contained
bFGF mrNA . -
pubmed
Additional
mice expressing point mutations in the cytoplasmic enzyme
superoxide dismutase (
SOD1 ) , the only known cause of
ALS , have proved that disease arises from a toxic property of the mutant enzyme rather than loss of enzymatic activity . -
pubmed
TS1 , the CBD , and an
IAP agonist peptide ( 4N1 K ) from the CBD of
TS1 activate the
platelet integrin alphaIIbbeta3 , resulting in platelet spreading on immobilized
fibrinogen , stimulation of
platelet aggregation , and enhanced
tyrosine phosphorylation of
focal adhesion kinase . -
pubmed
Test
bleeds were taken at 21 , 48 , 62 , and 84 days post immunization and the
rat sera were analyzed for
anti - OVA antibodies by enzyme linked immunosorbent assay ( ELISA ) . -
pubmed
Intravenous
immune globulin and
pseudohyponatremia . -
pubmed
Transforming growth factor - beta1 (
TGF - beta1 ) , a key
cytokine for control of cell growth , extracellular matrix formation , and
inflammation control , is secreted by many cells present in the arteriosclerotic plaque . -
pubmed
In conclusion ,
depression of
scavenger receptor function in monocytes by
TGF - beta1 in low concentrations reduces foam cell formation . -
pubmed
Use of
rifabutin with
protease inhibitors for
human immunodeficiency virus - infected patients with
tuberculosis . -
pubmed
CONTEXT : Although
niacin increases low levels of
high - density lipoprotein cholesterol (
HDL - C ) , which frequently accompany
diabetes , current guidelines do not recommend use of
niacin in
patients with
diabetes because of concerns about adverse effects on glycemic control ; however , this is based on limited clinical data . -
pubmed
MAIN OUTCOME MEASURES : Plasma lipoprotein ,
glucose ,
hemoglobin A(1c ) (
HbA ( 1c ) ) ,
alanine aminotransferase , and
uric acid levels ; hypoglycemic drug use ; compliance ; and adverse events , in
patients with
diabetes vs without who were receiving
niacin vs placebo . -
pubmed
RESULTS :
Niacin use significantly increased
HDL - C by 29 % and 29 % and decreased
triglycerides by 23 % and 28 % and
low - density lipoprotein cholesterol (
LDL - C ) by 8 % and 9 % , respectively , in participants with and without
diabetes ( P<.001 for
niacin vs placebo for all ) . -
pubmed
Corresponding changes in participants receiving placebo were increases of 0 % and 2 % in
HDL - C and increases of 7 % and 0 % in
triglycerides , and increases of 1 % and 1 % in
LDL - C.
Glucose levels were modestly increased by
niacin ( 8.7 and 6.3 mg / dL [ 0.4 and 0.3 mmol / L ] ; P = .04 and P<.001 ) in participants with and without
diabetes , respectively . -
pubmed
Levels of
HbA(1c ) were unchanged from baseline to follow - up in participants with
diabetes treated with
niacin . -
pubmed
In participants with
diabetes treated with placebo ,
HbA(1c ) decreased by 0.3 % ( P = .04 for difference ) . -
pubmed
CONCLUSIONS : Our study suggests that lipid - modifying dosages of
niacin can be safely used in
patients with
diabetes and that
niacin therapy may be considered as an alternative to statin drugs or
fibrates for
patients with
diabetes in whom these agents are not tolerated or fail to sufficiently correct
hypertriglyceridemia or low
HDL - C levels . -
pubmed
Bypassing
IgE and targeting T cells for specific immunotherapy of
allergy . -
pubmed
This has led to a growing consensus that plasma total and
low - density lipoprotein cholesterol (
LDL - C ) should be reduced to target levels that have been shown in population studies to be associated with low rates of
coronary heart disease (
CHD ) . -
pubmed
The aim of this study is to clarify whether the activation of a
Na (+)/ H (+ ) exchanger ( NHE ) is tightly concerned with neuronal and glial cell injury induced by
ischemia using a selective
NHE inhibitor ,
SM-20220 (
N -( aminoiminomethyl )- 1 - methyl-1H - indole-2 - carboxamide methanesulfonate ) . -
pubmed
Two hours of
hypoxia followed by 24 h of reoxygenation induced
lactate dehydrogenase (
LDH ) release , a marker of cell membrane damage , in cultured neurons and glia derived from
rats . -
pubmed
A standard
NHE inhibitor ,
5 -( N - ethyl - N - isopropyl )- amiloride , also reduced
LDH release in neurons at concentrations of more than 10(-7 ) mol / l. In a
rat transient
middle cerebral artery occlusion model , intravenous infusion of
SM-20220 reduced
cerebral infarction when the serum concentration of
SM - 20220 was maintained at about 10(-7 ) mol / l. These results suggest that the activation of the
NHE plays an important role in ischemic neuronal and glial cell injury , and
NHE inhibitor may have good therapeutic value for the treatment of
ischemic stroke . -
pubmed
Erythropoietin response to
anemia among
human immunodeficiency virus - infected infants in Malawi . -
pubmed
Enhancement of
cytarabine sensitivity in
squamous cell carcinoma cell line transfected with
deoxycytidine kinase . -
pubmed
The reason for this is thought to be that in cell lines of solid
tumors the expression of
cytidine deaminase , an enzyme that degrades
cytarabine , is high , whereas the expression of
deoxycytidine kinase (
dCK ) , which phosphorylates
cytarabine ( a prodrug ) , is weak . -
pubmed
METHODS :
Human SCC-25 squamous carcinoma cells were transfected by either retroviral vector or adenoviral vector containing
DCK gene and were identified for
dCK expression by Northern blot analysis . -
pubmed
CONCLUSION : The
dCK -
cytarabine system may be a useful approach for gene therapy of
squamous cell carcinomas of the head and neck . -
pubmed
Markers of
endothelial cell injury and
thrombin activatable fibrinolysis inhibitor in
nephrotic syndrome . -
pubmed
Markers of endothelial cell injury [
thrombomodulin ,
intracellular adhesion molecule ,
vascular cell adhesion molecule ,
thrombin activatable fibrinolysis inhibitor (
TAFI ) ,
protein Z ,
vascular endothelial growth factor , markers of
thrombin and
plasmin generation ] were studied in 22
patients with
nephrotic syndrome . -
pubmed
All these parameters studied , except
protein Z and D - dimers , were significantly higher in
patients with
nephrotic syndrome , whereas
protein Z was significantly lower when compared with the healthy volunteers . -
pubmed
None of the endothelial cell markers (
thrombomodulin ,
P - selectin ,
E - selectin ,
intracellular adhesion molecule ,
vascular cell adhesion molecule ) ,
thrombin and
plasmin generation markers (
thrombin -
antithrombin complexes ,
prothrombin fragments 1 + 2 ,
plasmin - antiplasmin complexes , D - dimers ) ,
protein C ,
protein Z ,
vascular endothelial growth factor , and
TAFI concentration and activity were directly correlated with the level of
proteinuria ,
albumin ,
cholesterol ,
triglycerides or
creatinine , except significant positive correlations between
TAFI activity and serum
creatinine ,
E - selectin and
albumin as well as negative correlations between
plasmin - antiplasmin complexes and
proteinuria . -
pubmed
Elevated circulating
TAFI antigen and activity might be a new link in the pathogenesis of impaired fibrinolysis and the progression of
atherosclerosis in
nephrotic syndrome . -
pubmed
For LMWH tests of
anti - Xa activities may only be necessary during weight adjusted treatment of pregnant
women ,
children , or cases with
reduced kidney function ( glomerular filtration rate & lt ; 30 ml / min . ) -
pubmed
High
glucose levels abolish antiatherosclerotic benefits of
ACE inhibition in
alloxan - induced
diabetes in
rabbits . -
pubmed
Renin -
angiotensin system activation is recognized to play an important role in
atherosclerosis . -
pubmed
This study aimed to verify the antiatherosclerotic effects of
ACE inhibition on an experimental model of
diabetes and
hypercholesterolemia . -
pubmed
Anticardiolipin and
anti - beta2 glycoprotein I antibodies in infants born to mothers with antiphospholipid antibody - positive
autoimmune disease : a follow - up study . -
pubmed
Infants born from mothers with antiphospholipid antibody ( aPL ) -positive
autoimmune disease were prospectively evaluated for anticardiolipin and anti -
beta2 glycoprotein I antibodies ( group 1 ) and for growth and neurological development . -
pubmed
The negativity of anticardiolipin in all infants at 12 months suggests that
anticardiolipin detection is the best assay to evaluate the disappearance of maternal
aPL and to estimate the potential risk of
thrombosis associated with these antibodies . -
pubmed
Here we describe a new approach for visualizing
tumors whose fluorescence can be detected using
telomerase - specific replication - competent adenovirus expressing green fluorescent protein ( GFP ) ( OBP-401 ) . -
pubmed
The
human epidermal growth factor receptor 2 (
HER2 ) is a member of the
epidermal growth factor receptor ( EGFR ) family , and it plays an important role in the development of many
human adenocarcinomas . -
pubmed
Comparison of
apolipoprotein B and
non - high - density lipoprotein cholesterol for identifying
coronary artery disease risk based on receiver operating curve analysis . -
pubmed
Histone deacetylase inhibitors exhibit anti - inflammatory and neuroprotective effects in a
rat permanent ischemic model of
stroke : multiple mechanisms of action . -
pubmed
The present study employed a
rat permanent
middle cerebral artery occlusion ( pMCAO ) model to study effects of
histone deacetylase (
HDAC ) inhibition on
ischemia - induced
brain infarction ,
neuroinflammation , gene expression , and
neurological deficits . -
pubmed
Moreover , injections with
HDAC inhibitors superinduced
heat - shock protein 70 and blocked pMCAO - induced down - regulation of
phospho -
Akt , as well as
ischemia - elicited up - regulation of
p53 ,
inducible nitric oxide synthase , and
cyclooxygenase-2 . -
pubmed
Together , our results demonstrate robust neuroprotective effects of
HDAC inhibitors against
cerebral ischemia - induced
brain injury . -
pubmed
Given that there is no effective treatment for
stroke ,
HDAC inhibitors , such as
VPA , SB , and
TSA , should be evaluated for their potential use for clinical trials in
stroke patients . -
pubmed
In this study , we determined the in vitro effect of
peroxisome proliferator - activated receptor - gamma (
PPAR - gamma ) activation on the aortic relaxation , lipolysis and
insulin - induced
[ ( 3 ) H ]- glucose uptake of the abdominal ( omental ) adipocytes of the non - diabetic ( + db/+m ) and
obese /
diabetic ( + db/+db )
mice . -
pubmed
Beckwith Wiedemann syndrome (
BWS ) and
Russell Silver syndrome (
RS ) are
growth disorders with opposing epimutations affecting the
H19 /
IGF2 imprinting center at 11p15.5 . -
pubmed
Overgrowth and
tumor risk in
BWS is caused by aberrant expression of the paternally expressed , imprinted
IGF2 gene , occurring as a consequence of mosaic hypermethylation within the imprinting center , or to mosaic paternal
uniparental disomy (
UPD ) . -
pubmed
A subset of
RS cases were recently shown to have mosaic hypomethylation within the
H19 /
IGF2 imprinting center , predicted to silence paternally expressed
IGF2 in early development . -
pubmed
Molecular diagnosis for
BWS and
RS involves methylation analysis of the
H19 locus , enabling discrimination of allelic methylation patterns . -
pubmed
We conclude that MS - HRM is a rapid , cost - effective , and sensitive method for screening mosaic methylation changes at the
H19 locus in
BWS and
RS . -
pubmed
CONCLUSIONS : Adolescent
HAP1 mice appear to be more vulnerable to the effects of footshock stress than adult
mice , as manifested by increased
alcohol drinking and
anxiety - related behavior in adulthood . -
pubmed
A
CACNB4 mutation shows that altered
Ca ( v ) 2.1 function may be a genetic modifier of severe
myoclonic epilepsy in infancy . -
pubmed
Mutations of
SCN1A , encoding the voltage - gated
sodium channel alpha1 subunit , represent the most frequent genetic cause of severe
myoclonic epilepsy in infancy (
SMEI ) . -
pubmed
All coding exons of
SCN1B ,
GABRG2 , and
CACNB4 genes were screened for mutations in 38
SCN1A - mutation - positive
SMEI probands . -
pubmed
Moreover , colonic
ulceration , leukocytic infiltration , and
cytokine levels (
TNF - alpha and
IL-6 ) were also decreased in the colons of herbal - treated
mice , reflected by H & amp ; E staining ,
MPO assay , and
cytokine ELISA . -
pubmed
Myeloperoxidase (
MPO)-specific antineutrophil cytoplasmic antibodies have been proposed as pathogenic for
microscopic polyangiitis . -
pubmed
Supporting this hypothesis , a case report of transplacental anti -
MPO antibody transfer presumably causing a
vasculitis - like syndrome in the newborn is cited frequently . -
pubmed
5 - hydroxytryptamine ( 5 - HT )( 1A ) receptors are known to play a pivotal role in the 5 - HTergic mechanisms associated with the etiology of
stress - related disorders . -
pubmed
A recent report in the New England Journal of Medicine on the early clinical evaluation of
Olaparib in
cancers lacking the
BRCA1 or
BRCA2 genes exemplifies this promising new trend . -
pubmed
Melanoma hyperpigmentation is strongly associated with
KIT alterations . -
pubmed
KIT alterations have been identified in
melanoma and treatment with
imatinib has met with some success . -
pubmed
However , the relationship between
KIT and
melanoma histology remains uncharacterized , and its role in
melanoma pathogenesis unknown . -
pubmed
Cases were analyzed for
KIT protein expression relative to histologic variables : subtype ,
sun damage ,
tumor infiltrating lymphocytes ,
melanoma in situ , vertical growth phase ( VGP ) , location , and
hyperpigmentation . -
pubmed
Although
KIT mutations were uncommon overall ,
pigmentation in conjunction with immunohistochemistry and nodular growth phase raised their frequency to 2 ( 40 % ) of 5 cases . -
pubmed
We expand the context of
KIT aberrations to involve areas other than acral and mucosal sites and demonstrate an inverse relationship between
KIT abnormalities and
sun damage . -
pubmed
There is a strong correlation to
hyperpigmentation that overrides factors including
sun damage ,
tumor location , and histologic subtype , which may be used to identify cases with
KIT aberrations . -
pubmed
In conclusion , cell apoptosis and G(2 ) phase arrest mediated by
Cdc25C ,
Cdc2 and
cyclinB1 may be the initiating event in the
gastric toxicity of
OTA . -
pubmed
A total of 50 consecutive
patients ( median age , 57.5 years ) with
AML ( n=30 ) or
myelodysplasia (
MDS , n=20 ) underwent
HLA matched related donor ( MRD , n=27 ) or unrelated donor ( MUD , n=23 ) peripheral blood hematopoietic cell transplantation after nonmyeloablative CY /
fludarabine (
Flu ) conditioning . -
pubmed
Of 14 survivors with
cGVHD , 5 ( 35.7 % ) experienced resolution off immunosuppression , suggesting that tolerance with
HLA matched grafts is possible at an advanced age by this method . -
pubmed
The
neurological impairment was regressive within 6 months after intravenous
immunoglobulin treatment followed by intravenous then oral
corticosteroid administration . -
pubmed
Specificity of
brachyury in the distinction of
chordoma from
clear cell renal cell carcinoma and
germ cell tumors : a study of 305 cases . -
pubmed
Brachyury is recognized as a specific marker for notochord - derived tissues and
neoplasms , and has become a defining immunohistochemical feature of
chordoma . -
pubmed
The main differential diagnostic consideration for
chordoma is
chondrosarcoma , which is known to lack
brachyury expression . -
pubmed
Although immunoreactivity for
brachyury has been reported in a few
germ cell tumors , a thorough characterization of staining by specific subtype has not been performed in a large series . -
pubmed
Additionally ,
brachyury expression in
clear cell renal cell carcinoma has not been well studied . -
pubmed
In this study , immunohistochemical expression with the
brachyury antibody was evaluated in 111
germ cell tumors , 30
non - neoplastic and neoplastic ( non - germ cell ) testicular tissues , and 184 metastatic
clear cell renal cell carcinomas using tissue microarray technology . -
pubmed
In addition , immunoreactivity for
PAX-8 and
SALL-4 was evaluated in 12
chordomas on whole section . -
pubmed
No nuclear
brachyury expression was identified in any of the 101
germ cell tumors within the tissue microarray ( including
choriocarcinoma ( 1 ) , embryonal
carcinoma ( 20 ) ,
intratubular germ cell neoplasia unclassified ( 2 ) ,
seminoma ( 64 ) ,
spermatocytic seminoma ( 1 ) ,
teratoma ( 5 ) and
yolk sac tumor ( 8) ) , in any of the 30
non - neoplastic and neoplastic ( non - germ cell ) testicular tissues , or in any of the 10 whole - section
seminomas . -
pubmed
All 184 metastatic clear cell
renal cell carcinomas were also non - reactive for
brachyury . -
pubmed
All 12
chordomas showed strong nuclear immunoreactivity for
brachyury , but no expression of
SALL-4 . -
pubmed
In all , 1 of 12
chordoma cases showed patchy , 1 + nuclear immunoreactivity for
PAX-8 . -
pubmed
This study confirms the specificity of
brachyury for
chordoma in the differential diagnostic distinction from the potential genitourinary mimics ,
germ cell tumors and
metastatic clear cell renal cell carcinoma . -
pubmed
Observed and predicted total pubertal growth during treatment with
growth hormone in
adolescents with
idiopathic growth hormone deficiency ,
Turner syndrome ,
short stature , born small for gestational age and
idiopathic short stature : KIGS analysis and review . -
pubmed
Mutations in the
p53 Tumor Suppressor Gene : Important Milestones at the Various Steps of Tumorigenesis . -
pubmed
Inactivation of the
p53 tumor suppressor is a frequent event in tumorigenesis . -
pubmed
In most cases , the
p53 gene is mutated , giving rise to a stable mutant protein whose accumulation is regarded as a hallmark of
cancer cells . -
pubmed
Mutant
p53 proteins not only lose their
tumor suppressive activities but often gain additional oncogenic functions that endow cells with growth and survival advantages . -
pubmed
Interestingly , mutations in the
p53 gene were shown to occur at different phases of the multistep process of malignant transformation , thus contributing differentially to
tumor initiation , promotion , aggressiveness , and metastasis . -
pubmed
Here , the authors review the different studies on the involvement of
p53 inactivation at various stages of
tumorigenesis and highlight the specific contribution of
p53 mutations at each phase of
cancer progression . -
pubmed
Caspase inhibitors also altered cellular ultrastructure , resulting in features suggestive of
necrosis rather than apoptosis . -
pubmed
The Gln1233ter mutation of the
myosin binding protein C gene : causative mutation or innocent polymorphism in patients with
hypertrophic cardiomyopathy ? -
pubmed
To investigate the individual and combined roles of
NDST1 and
NDST2 during
MC development , in vitro differentiated MCs derived from
mouse embryos and embryonic stem cells , respectively , have been studied . -
pubmed
Depression is characterized by aberrations in six intertwined pathways : ( 1 ) inflammatory pathways as indicated by increased levels of proinflammatory
cytokines , e.g. -
pubmed
GSK-3 inhibitors have antidepressant effects in
animal models of
depression . -
pubmed
MARK pathway ,
TGFbeta pathway and cell cycle ) Through the investigation on methylation , we found that most of the
CRC related genes and miRNAs were prone to be regulated by methylation . -
pubmed
We conducted a cross - sectional study and assessed the association of the
methylenetetrahydrofolate reductase (
MTHFR ) C677 T variant with features of
MetS in SGA - treated ( n=105 ) and SGA - naive ( n=112 ) children . -
pubmed
We targeted the
MTHFR C677 T variant , because it is associated with risk for
cardiovascular disease , and features of
MetS in adults without
psychiatric illness . -
pubmed
MetS in children is based on the presence of any three of the following : waist circumference & gt;= 90th percentile for age and sex ; plasma
triglyceride & gt;= 1.24 mmol l(-1 ) ; plasma
high - density lipoprotein -
cholesterol & lt;= 1.03 mmol l(-1 ) ; systolic or diastolic blood pressure & gt;= 90th percentile for age , sex , and height ; and fasting
glucose & gt;= 5.6 mmol l(-1 ) . -
pubmed
The
MTHFR 677 T allele was associated ( P<0.05 ) with
MetS ( OR 5.75 , 95 % CI= 1.18 - 28.12 ) in SGA - treated children . -
pubmed
These findings illustrate the high prevalence of
MetS in SGA - treated children and suggest metabolic alterations associated with the
MTHFR C677 T variant may have a role in the development of
MetS features in SGA - treated children . -
pubmed
RESULTS : IP applied alone caused a mild
pancreatic damage associated with a limited increase in
plasma amylase activity , concentration of pro - inflammatory
interleukin-1beta and plasma level of D - dimer . -
pubmed
Both these procedures caused a similar reduction in
plasma lipase ,
amylase and
interleukin-1beta , as well as in histological signs of
pancreatic damage . -
pubmed
It was manifested by an increase in
pancreatic damage and plasma level of
lipase ,
amylase and
interleukin-1beta , as well as by reduction in pancreatic DNA synthesis and plasma concentration of D - dimer and
interleukin-10 . -
pubmed
We suggest that the combination of abhorrent UPR signaling , promotion of cell death , and increased innate immune responses contributes to the replication defects in
ATF6 - deficient cells , thus demonstrating the dual importance of
ATF6 in maintaining cell viability and modulating immune responses during
WNV ( KUN ) infection . -
pubmed
The transcription factor
Fosl1 plays a key role in the vasculogenic and angiogenic processes as
Fosl1 knockout embryos die with
vascular defects in extraembryonic tissues . -
pubmed
In a
T47D cell - based reporter assay , 1 and 2 potently inhibited
hypoxia - induced
HIF-1 activation ( IC50 values 0.18 and 1.10 mugmL(-1 ) , respectively ) . -
pubmed
One surprising observation was that , while less potent , the purported
cancer chemopreventive agent
auraptene ( 8) was found to act as a mitochondrial poison that disrupts
HIF-1 signaling in
tumors . -
pubmed
To evaluate their anti - allergic inflammatory activities , the inhibitory effects of isolates ( 1 - 7 ) on
histamine release and on the gene expressions of
tumor necrosis factor ( TNF )- a and
interleukin ( IL )- 6 were examined using
human mast cells ; previous studies have reported that
TNF - alpha and
IL-6 release from mast cells is positively related to the severity of
allergic symptoms . -
pubmed
obtusiloba inhibit mast - cell - derived
allergic inflammation ,
histamine , and proinflammatory
cytokines . -
pubmed
A Case of Multifocal
Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with
BRAF K601E Mutation and Three Conventional Types with
BRAF V600E Mutation . -
pubmed
This case genetically demonstrates unique features including the simultaneous presence of the
BRAF V600E ( T1799A ) mutation and the
BRAF K601E ( A1801 G ) mutation in conventional
PTC and FVPTC , respectively . -
pubmed
Regulation of the
V - ATPase by
AMPK may couple
V - ATPase activity to cellular metabolic status with potential relevance to
ischemic injury in the kidney and other tissues . -
pubmed
TOX3 mutations in
breast cancer . -
pubmed
TOX3 maps to 16q12 , a region commonly lost in
breast cancers and recently implicated in the risk of developing
breast cancer . -
pubmed
However , not much is known of the role of
TOX3 itself in
breast cancer biology . -
pubmed
This is the first study to determine the importance of
TOX3 mutations in
breast cancers . -
pubmed
We screened
TOX3 for mutations in 133
breast tumours and identified four mutations ( three missense , one in - frame deletion of 30 base pairs ) in six primary
tumours , corresponding to an overall mutation frequency of 4.5 % . -
pubmed
Whilst copy number changes of 16q12 are common in
breast cancer , our data show that mutations of
TOX3 are present at low frequency in
tumours . -
pubmed
Our results support that
TOX3 should be further investigated to elucidate its role in
breast cancer biology . -
pubmed
[ Associations of
ulcerative colitis with
vitamin D receptor gene polymorphisms and serum levels of
25 - hydroxyl vitamin D ] . -
pubmed
OBJECTIVE : To explore the associations of
ulcerative colitis (
UC ) with
vitamin D receptor (
VDR ) gene polymorphisms and serum levels of
25 - hydroxyl vitamin D[
25 ( OH ) D ] . -
pubmed
The frequencies of minor allele and genotype of
VDR were compared between
UC patients and the controls by chi(2 ) test and Bonferroni correction . -
pubmed
RESULTS : After Bonferroni correction , mutant allele and genotype frequencies of
VDR (
Fok I ,
Bsm I ,
Apa I ,
Taq I ) did not statistically differ between
UC patients and the controls ( all P & gt ; 0.012 5 ) . -
pubmed
Stratification by the Truelove & amp ; Witts severity index , mutant allele ( C ) and genotype ( TC+CC ) of
VDR(Fok I ) were significantly higher in patients with mild and moderate
UC than in those with severe
UC ( 54.37 % ( 373/686 ) vs 37.70 % ( 46/122 ) , 81.92 % ( 281/343 ) vs 55.74 % ( 34/61 ) , both P & lt ; 0.01 ) . -
pubmed
By linear regression analysis , the serum levels of
25 ( OH ) D in
UC patients were independently and positively correlated with
hemoglobin ( beta = 0.499 , P & lt ; 0.01 ) and yet independently and negatively correlated with
C - reaction protein ( beta = -0.346 , P & lt ; 0.01 ) and white blood cells ( beta = -0.291 , P = 0.002 ) . -
pubmed
Using Logistic regression analysis , it was found that mutant genotype ( GA / AA ) of
VDR (
Bsm I ) played an independently protective role in
UC ( OR = 0.328 , P = 0.028 ) while mutant genotype ( TC / CC ) of
VDR ( Fok I ) and
vitamin D deficiency ( & lt;50.0 nmol / L ) had an interaction in
UC ( OR = 2.070 , P = 0.006 ) . -
pubmed
CONCLUSIONS : Genetic polymorphism of
VDR (
Fok I ,
Bsm I ,
Apa I ,
Taq I ) and serum levels of
25 ( OH ) D are significantly correlated with
UC . -
pubmed
Mutation of
VDR (
Bsm I ) is a protective factor for
UC . -
pubmed
Moreover , mutant genotype ( TC / CC ) of
VDR (
Fok I ) and
vitamin D deficiency may exert synergistic effects on the susceptibility to
UC . -
pubmed
PATIENTS AND METHODS : Immunohistochemical profiles of
HPV - related cell cycle markers , including
p16 ,
pRb ,
cyclin D1 ,
p53 , and the
HPV DNA status of 42 consecutive
TSCC patients who underwent TLO - based treatments were analyzed . -
pubmed
RESULTS : Univariate analysis indicated that high
p16 , low
pRb , and low
p53 expression levels are significantly associated with a good
disease - free and overall survival outcome . -
pubmed
High expression of
erythropoietin - producing
hepatoma cell line - B2 (
EphB2 ) predicts the efficiency of the Qingyihuaji formula treatment in
pancreatic cancer CFPAC-1 cells through the
EphrinB1 -
EphB2 pathway . -
pubmed
Our previous study demonstrated that inhibition of
erythropoietin - producing
hepatoma cell line - B2 (
EphB2 ) expression resulted in the promotion of
cancer growth , with
EphB2 acting as a tumor suppressor in
pancreatic cancer . -
pubmed
In the current study , the different effects on
tumor growth inhibition following QYHJ treatment in cells with different levels of
EphB2 expression were investigated to reveal the mechanism . -
pubmed
A subcutaneously transplanted
tumor model using
cancer cells with different levels of
EphB2 expression were established in vivo and received a four - week QYHJ intervention . -
pubmed
The results showed that the
tumor weight inhibitory rate was 31.40 , 31.33 and 18.36 % in
CFPAC-1 ,
CFPAC-1 control RNAi and
CFPAC-1 EphB2 RNAi cells following QYHJ treatment , respectively . -
pubmed
Therefore ,
EphB2 acts as a predictive factor for QYHJ treatment in
pancreatic cancer CFPAC-1 cells . -
pubmed
We apply SigFuge to RNA - seq cohorts of 177 lung and 279
head and neck squamous cell carcinoma samples from the Cancer Genome Atlas , and identify several cases of differential isoform usage including
CDKN2A , a
tumor suppressor gene known to be inactivated in a majority of
lung squamous cell tumors . -
pubmed
For the first time , we here report exonic deletions of
CTNND2 causing low normal IQ with
learning difficulties with or without
autism spectrum disorder . -
pubmed
PATIENTS :
Men who presented for endocrine evaluation from 2011 to 2014 with
testosterone levels & lt;10.4 nmol / L ( 300 ng / mL ) , normal
LH and
FSH levels and no known
pituitary disease . -
pubmed
Sex differences in
glutamate receptor gene expression in major
depression and suicide . -
pubmed
CD19+
CD24hiCD38hiBregs involved in downregulate helper T cells and upregulate regulatory T cells in
gastric cancer . -
pubmed
We characterized the role of
Bregs in the progression of
gastric cancer . -
pubmed
We detected an increase in Bregs producing
IL-10 both in peripheral blood mononuclear cells ( PBMCs ) and in gastric
tumors . -
pubmed
Collectively , these findings demonstrate that increased Bregs play a immunosuppressive role in
gastric cancer by inhibiting T cells
cytokines as well as conversion to Tregs . -
pubmed
The disease is characterized by type 1
hypersensitivity to fungal allergens , dramatically elevated total serum
IgE , accumulation of thick eosinophil - laden mucin with non - invasive fungal hyphae within the paranasal sinuses ,
nasal polyposis , and sinus bony remodeling . -
pubmed
This study was designed to compare effectiveness and safety of
warfarin , direct
thrombin inhibitor
dabigatran , Xa factor inhibitors
rivaroxaban and
apixaban used to prevent
stroke in 280 elderly
patients in
patients with age - specific non - valvular
atrial fibrillation . -
pubmed
Hemoglobin A1c is the measurement of glycated
hemoglobin and can aid in both the diagnosis and continued management of
diabetes mellitus . -
pubmed
Accurate glycosylated
hemoglobin A1c ( A1c ) measurements are an essential part of decision making in the diagnosis and treatment of
type 2 diabetes mellitus . -
pubmed
Microangiopathic hemolytic anemia due to
ADAMTS-13 loss in
idiopathic systemic capillary leak syndrome : comment . -
pubmed
Recombinase polymerase amplification ( RPA ) has emerged as a novel isothermal amplification technology for the molecular diagnosis of
infectious diseases . -
pubmed
In this in vitro experiment , we obtained
RAW264.7 macrophages and
human peripheral blood mononuclear cells ( PBMCs ) incubated by LPS or plasma from
septic patients to explore the
NF - kappaB pathway in the effect of the inhalation of
sevoflurane combined with
oxygen in
sepsis . -
pubmed
We also founded that 0.5 MAC of
sevoflurane in 60 %
oxygen inhibited the nuclear translocation of
NF - kappaB in
human PBMCs induced by LPS or plasma from
septic patients . -
pubmed
The subanesthesia dose
sevoflurane in 60 %
oxygen may reduce
sepsis - induced inflammatory responses in animals and in PBMCs , and the inhibition to the activation of the
NF - kappaB pathway may contribute to this protection . -
pubmed
EGFR Mutation Status in Lung
Adenocarcinoma - Associated
Malignant Pleural Effusion and Efficacy of
EGFR Tyrosine Kinase Inhibitors . -
pubmed
The aim of this study was to investigate
epidermal growth factor receptor (
EGFR ) mutation status in
lung adenocarcinoma - associated
MPEs ( LA -
MPEs ) and its correlation with efficacy of
EGFR tyrosine kinase inhibitor ( TKI ) therapy . -
pubmed
Materials and Methods : Samples comprised 40 cell blocks of pathologically - confirmed LA -
MPEs collected before the start of
EGFR TKI therapy . -
pubmed
The objective response rate ( ORR ) of 26 patients with
EGFR mutations in LA -
MPEs among the 36 patients with measurable lesions was 80.8 % , while the ORR of the 10 patients with wild - type
EGFR in LA -
MPEs was 10 % ( p & amp;lt ; 0.001 ) . -
pubmed
Among the 26 patients with
EGFR mutations in LA -
MPEs , the ORR of target
lesions and LA -
MPEs were 88.5 % and 61.5 % , respectively ( p=0.026 ) . -
pubmed
Conclusion :
EGFR mutation status in cell blocks of LA -
MPEs confirmed by pathologic diagnosis is highly predictive of
EGFR TKI efficacy . -
pubmed
For patients with
EGFR mutations in LA -
MPEs , the response to
EGFR TKIs seems to be worse for
pleural effusions than for solid
tumors . -
pubmed
Characterization of the
LECT2 gene and its protective effects against
microbial infection via large lymphocytes in
Lampetra japonica . -
pubmed
Leukocyte cell - derived chemotaxin 2 (
LECT2 ) is a multifunctional protein of the innate immune system that defends against
bacterial infections and chemotactic activity . -
pubmed
A study of
serum vascular endothelial growth factor in
infantile hemangiomas . -
pubmed
Aims : To study the clinicoepidemiological profile of
infantile hemangiomas , to estimate and compare the serum levels of
VEGF in
infantile hemangiomas and controls , and to determine correlations between serum levels of
VEGF and growth characteristics of
infantile hemangiomas . -
pubmed
There were no statistically significant correlations between serum
VEGF levels and sex or size , phase of growth , morphological variants or
ulceration of lesions . -
pubmed
Conclusions : The mean value of serum
VEGF in the study group was significantly higher than that in the control group , suggesting that serum
VEGF can serve as a diagnostic marker of
infantile hemangiomas . -
pubmed
Mean serum
VEGF was higher in proliferative lesions than in involuting lesions , indicating that it may also be useful as a prognostic serological marker in cases of
infantile hemangioma . -
pubmed
Electron microscopy analysis of
human tissue samples with
necrotizing fasciitis confirmed increased
C4BP binding to
S. - pubmed
In vivo studies reveal that
IrM2 can significantly inhibit
tumor growth in a
mouse model . -
pubmed
Abstract :
Cyclin D1 is linked with the development and progression of
oral squamous cell carcinoma (
OSCC ) . -
pubmed
This case - control study was directed to characterise the immunoreactivity of the protein
cyclin D1 and its correlation with the clinicopathological parameters of
patients with
OSCC and potentially
malignant disorders (
PMD ) . -
pubmed
A group of
patients with
OSCC were followed up after treatment , and the
cyclin D1 expression was reviewed for correlation of
cyclin D1 expression with prognosis of the
patients . -
pubmed
Results : Age , gender and site showed no statistically significant correlation with
cyclin D1 expression in
OSCC and
PMD . -
pubmed
The
cyclin D1 score did not show a significant difference with histopathological diagnosis of
OSCC . -
pubmed
Cyclin D1 was not expressed in 60 % of the Control and 30 %
PMD cases while the expression of
cyclin D1 was seen in 100 % of
OSCC cases although
cyclin D1 score did not show a statistically significant association in the prognosis of the
disease among the
OSCC patients . -
pubmed
Echocardiographic analyses showed that , compared with wild - type infarcted control
mice ,
AID-/-muS-/-
mice exhibited improved cardiac function and reduced remodeling on day 56 post -
MI . -
pubmed
An unbiased screening of the heart reactivity potential in the plasma of wild - type
MI animals revealed the presence of antibodies that target the myocardial scar and
collagenase - sensitive epitopes . -
pubmed
Phosphatidylinositol 3 - kinase delta pathway : a novel therapeutic target for
Sjogren ' s syndrome . -
pubmed
BACKGROUND : The
phosphatidylinositol 3 - kinase delta isoform (
PI3Kdelta ) belongs to an intracellular lipid kinase family that regulate lymphocyte metabolism , survival , proliferation , apoptosis and migration and has been successfully targeted in
B - cell malignancies . -
pubmed
Given the central role of B cells in
pSS pathogenesis , we investigated
PI3Kdelta pathway activation in
pSS and the functional consequences of blocking
PI3Kdelta in a
murine model of
focal sialoadenitis that mimics some features of
pSS . -
pubmed
METHODS AND RESULTS : Target validation assays showed significant expression of phosphorylated
ribosomal protein S6 (
pS6 ) , a downstream mediator of the
phosphatidylinositol 3 - kinase delta (
PI3Kdelta ) pathway , within
pSS salivary glands . -
pubmed
In vivo blockade of
PI3Kdelta activity with
seletalisib , a
PI3Kdelta - selective inhibitor , in a
murine model of focal
sialoadenitis decreased accumulation of lymphocytes and plasma cells within the glands of treated
mice in the prophylactic and therapeutic regimes . -
pubmed
CONCLUSION : These data demonstrate activation of
PI3Kdelta pathway within the glands of
patients with
pSS and its contribution to disease pathogenesis in a model of disease , supporting the exploration of the therapeutic potential of
PI3Kdelta pathway inhibition in this condition . -
pubmed
The Further Cardiovascular Outcomes Research with
PCSK9 Inhibition in
Subjects with Elevated Risk ( FOURIER ) and Evaluation of Cardiovascular Outcomes After an
Acute Coronary Syndrome During Treatment With Alirocumab ( ODYSSEY OUTCOMES ) studies , with the two available
PCSK9 antagonists , i.e. -
pubmed
Interest has been expanded to areas not only limited to low - density lipoprotein
cholesterol reduction but also investigating other non - lipid pathways raising cardiovascular risk , in particular
inflammation associated to raised high - sensitivity
C - reactive protein levels , not significantly affected by the present
PCSK9 antagonists . -
pubmed
We identified adult
patients with
muscle injury from ICD-10AM codes ,
serum creatine kinase level greater than 1000 U / ml , and a clinical history consistent with
rhabdomyolysis . -
pubmed
Compared to the rest of the cohort , patients who used illicit drugs were younger and had higher peak
serum creatinine kinase , and developed a higher severity of
acute kidney injury . -
pubmed
In multivariable analysis , the factors associated with
acute kidney injury were illicit drug use , peak
creatine kinase ,
cardiovascular disease , concurrent
sepsis and a clinically - evident
pressure injury . -
pubmed
CONCLUSIONS : Illicit drug use was associated with
acute kidney injury and renal replacement therapy independent of
creatine kinase levels . -
pubmed
Mean Urine
albumin - to -
creatinine ratio ( UACR ) was 0.02 , and 166 subjects showed significant
albuminuria ( UACR & gt;= 0.03 ) . -
pubmed
Expanding the phenotypic spectrum of
Allan - Herndon - Dudley syndrome in patients with
SLC16A2 mutations . -
pubmed
The aim of the study was to redefine the phenotype of
Allan - Herndon - Dudley syndrome (
AHDS ) , which is caused by mutations in the
SLC16A2 gene that encodes the brain transporter of thyroid hormones . -
pubmed
WHAT THIS PAPER ADDS :
Mild intellectual disability is associated with
SLC16A2 mutations . -
pubmed
Patients with
SLC16A2 mutations present a broad spectrum of neurological phenotypes that are also observed in other
hypomyelinating disorders . -
pubmed
The
macrosomia rate was higher in the
glibenclamide - exposed group than the
insulin - alone group ( 12.2 % vs 0 % , P=0.025 ) . -
pubmed
In a low-/middle - income country setting with a high prevalence of
HIV and high usage of OHAs as an alternative to
insulin therapy ,
HIV might be associated with higher PNM and
glibenclamide with increased rates of
macrosomia , which warrants further exploration . -
pubmed
Here , we show that intravenously injected
carbon quantum dots , functionalized with multiple paired
alpha - carboxyl and
amino groups that bind to the large
neutral amino acid transporter 1 ( which is expressed in most
tumours ) , selectively accumulate in
human tumour xenografts in
mice and in an orthotopic
mouse model of
human glioma . -
pubmed
High shear stress in the mechanical device results in
acquired von Willebrand syndrome (
AVWS ) , characterized by a loss of high - molecular - weight multimers of
von Willebrand factor (
VWF ) leading to an increased
bleeding risk . -
pubmed
Etiological models for
AVWS are increased cleavage by the
metalloproteinase ADAMSTS13 , mechanical destruction of
VWF , and shear - induced
VWF binding to platelets . -
pubmed
AVWS can be diagnosed by detection of
VWF multimers using gel - electrophoresis and functional assays of varying sensitivity (
VWF ristocetin cofactor activity ,
VWF activity ,
VWF collagen binding ) . -
pubmed
Glucagon like peptide-2 for Intestinal stem cell and Paneth cell repair during
graft - versus - host disease in
mice and
humans . -
pubmed
We observed that acute
GVHD reduced intestinal
GLP-2 levels in
mice and
patients developing
GVHD . -
pubmed
Treatment with the
GLP-2 agonist ,
teduglutide , reduced de novo acute
GVHD and
steroid - refractory
GVHD , without compromising
graft - versus - leukemia (
GVL ) effects in multiple
mouse models . -
pubmed
Our findings indicate that L - cells are a target of
GVHD and that
GLP-2 - based treatment of acute
GVHD restores intestinal homeostasis via an increase of ISCs and PCs without impairing GVL effects . -
pubmed
Angiotensin - converting enzyme 2 (
ACE2 ) has been identified as the functional receptor of
severe acute respiratory syndrome coronavirus 2 (
SARS - CoV-2 ) and a target for disease prevention . -
pubmed
However , the relationship between
ACE2 expression and its clinical implications in
SARS - CoV-2 pathogenesis remain unknown . -
pubmed
Glucose oxidase (
GOx)-mediated starvation therapy has demonstrated good application prospect in
cancer treatment . -
pubmed
The modification of HA on
Pd@
Pt - GOx could block the GOx activity ,
catalase (
CAT)-like and
peroxidase (
POD)-like activities of
Pd@
Pt , reduce the
cytotoxicity to normal cells and organs , and effectively target
CD44 - overexpressed
tumors by active targeting and passive enhanced permeability and retention ( EPR ) effect . -
pubmed
Meanwhile , the upregulated acidity and
H2O2 content in the
tumor region generated by GOx catalytic oxidation of
glucose dramatically facilitated the pH - responsive
POD - like activity of the
Pd@
Pt nanozyme , which then catalyzed degradation of the
H2O2 to generate abundant highly toxic
OH , thereby realizing nanozyme - mediated starving - enhanced chemodynamic cancer therapy . -
pubmed
Molecular subtype - specific responses of
colon cancer cells to the
SMAC mimetic
Birinapant . -
pubmed
Due to the multiple molecular mechanisms - of - action of these targets , responses to
IAP antagonist may differ between molecularly distinct
colon cancer cells . -
pubmed
In this study , responses to the
IAP antagonist
Birinapant and
oxaliplatin/
5 - fluorouracil (
5 - FU ) were investigated in 14
colon cancer cell lines , representing the consensus molecular subtypes (
CMS ) . -
pubmed
Collectively , our study demonstrates that
IAP inhibition is a promising modulator of response to
oxaliplatin/
5 - FU in
colorectal cancers of the CMS1 subtype , and may show promise as in the CMS2 subtype , suggesting that molecular subtyping may aid as a patient stratification tool for
IAP antagonists in this disease . -
pubmed
Endoplasmic reticulum aminopeptidase 2 ,
ERAP2 , is an emerging pharmacological target in
cancer immunotherapy and control of
autoinflammatory diseases , as it is involved in antigen processing . -
pubmed
CONCLUSIONS : The comorbidity of
malaria and
intestinal helminths causes lower
hemoglobin level leading to
maternal anemia ,
preterm delivery , and still birth in pregnant women and lactating mother . -
pubmed
Complexes of
breast - cancer - associated antigen ( s ) and corresponding antibodies in
pleural effusions from a
patients with
breast cancer . -
pubmed
[ Liver and
serum alkaline phosphatase in
cancer of the gastrointestinal tract ] . -
pubmed
CD5 - negative cell mediated experimental
hypersensitivity pneumonitis . -
pubmed
This work confirms the loss of
HRAS alleles in 1 out of 2 cases of invasive
ovarian cancer as determined in 32 samples or cell lines derived from 19 patients . -
pubmed
Infection specific
prion protein (
PrP ) accumulates on neuronal plasmalemma in
scrapie infected
mice . -
pubmed
Prion protein (
PrP ) is an abundant membrane - associated host protein which accumulates in abnormal , relatively protease - resistant forms in the brains of animals with
scrapie and related diseases . -
pubmed
Using correlative light and electron microscopy we determined the sites of subcellular localisation of
PrP in
mice infected with the 87V strain of
scrapie . -
pubmed
Moreover , the absence of a specific
IgE response or of particulate masses of
Ig or complement , made it unlikely an
anaphylactoid or Arthus - type reaction could have been responsible . -
pubmed
It is concluded that those with frequent occupational exposure to M
tuberculosis have larger numbers of circulating T cells reactive with mycobacterial
antigens , so that the development of the skin test response to
tuberculin is less dependent on " by - stander " cell infiltration to mediate the delayed
hypersensitivity reaction than the reactions in those with less intense and less frequent natural exposure . -
pubmed
One year later , it was revealed that she suffered from
ATL , confirmed by the presence of ATL cells in peripheral blood and
anti - ATLA antibody . -
pubmed
In both cases the nature of the
hepatic lesion was already clear before biopsy , from characteristic ultrasound , CT - scan , and a progressive rise in
CEA levels . -
pubmed
The role of
histamine in
cardiac anaphylaxis ; characterization of
histaminergic H1 - and H2 - receptor effects . -
pubmed
In addition , serum from those with larger
burns caused a marked reduction in the
interleukin-2 receptor - labeling index , suggesting that it possesses factor(s ) that directly or indirectly block
T lymphocyte interleukin-2 receptor expression . -
pubmed
Modified responsiveness of
v - Ha - ras - transfected
rat fibroblasts to
growth factors and a
tumor promoter . -
pubmed
The correlation of the phenotypic changes of
v - Ha - ras transfected cells with the expression of
p21ras and the modified responses to
growth factors and a
tumor promoter were examined . -
pubmed
A
tumor promoter ,
12 - O - tetradecanoylphorbol-13 - acetate (
TPA ) also augmented anchorage - independent growth of
ras - transformed cells and induced morphological changes in monolayer cultures without altering the expression of the
ras gene or phosphorylation of the
p21ras protein . -
pubmed
Transplantation of a large inoculum of incubated islets of
MHC - compatible donors led to an extended survival of the grafts to an average of greater than 86 days in 71 % of male
diabetic BB / W recipients . -
pubmed
Long - lasting
prolactin - lowering effect of
cabergoline , a new
dopamine agonist , in
hyperprolactinemic patients . -
pubmed
After
cabergoline treatment ,
serum GH levels did not change significantly in either nonacromegalic or
acromegalic patients , whereas the two
dopamine - responsive
acromegalic patients had a marked
GH fall after
bromocriptine . -
pubmed
Thirty - three out of 133 children ( 24.8 % ) tested for
serum HBsAg were found positive : 26 ( 78.7 % ) of them developed
chronic hepatitis . -
pubmed
Anthropometric parameters -- weight loss , arm muscle circumference , skin - fold thickness -- and biochemical parameters --
serum albumin and delayed cutaneous
hypersensitivity reactions to purified protein derivative ( PPD ) and
phytohemagglutinin (
PHA)--were used for nutritional assessment . -
pubmed
Ca2 + -dependence of
thrombin - induced aggregation and
MDA formation , and Ionophore
A23187 - induced aggregation of the platelets from SHRSP at a
hypertensive age(16 - weeks ) was similar to that of the aggregation of platelets from age - matched WKY . -
pubmed
These results suggest that abnormalities of SHRSP platelets at
hypertensive ages are due to an impaired function of
thromboxane A2 and/or
calcium concerned in aggregation and secretion but not due to a defect in
cyclo - oxygenase and
thromboxane synthetase pathway . -
pubmed
Tumor foci were detected in frozen serial sections stained histochemically for
estrase activity . -
pubmed
The ability of these
stilbene and steroidal
estrogens to compete for
renal tumor estrogen receptor generally correlated well with their ability to cause
renal tumorigenesis in the
hamster with one notable exception . -
pubmed
Our results demonstrate that the
cytochrome P450 isoenzymes responsible for the different pathways of
antipyrine metabolism are affected to different extents by
cirrhosis . -
pubmed
The relative excess of alpha- over
beta - globin chains in the erythroid precursors is the chief pathophysiological factor of homozygous
beta - thalassemia . -
pubmed
Differential expression of
glial fibrillary acidic protein (
GFAP ) in the retinae and visual cortices of
rats with experimental
renal hypertension . -
pubmed
To examine the expression of the
GFAP protein in the retina and visual cortex under normal and pathological conditions ,
hypertension was induced in adult male
Sprague - Dawley rats by applying
silver clips onto renal arteries and the change in
GFAP expression was followed by Western blotting and immunocytochemical staining . -
pubmed
One week after operation when the induced
hypertension was at the initial stage ,
GFAP expression in the retina was reduced to half of the sham control . -
pubmed
By 4 weeks , when consistent
hypertension was developed , a further decrease in the level of
GFAP expression in the retina to one third of the sham control was observed . -
pubmed
Immunocytochemical staining showed that the number of
GFAP - positive cells in the nerve fiber layer of the retina of the
hypertensive rat was reduced to less than one third of the sham control . -
pubmed
However , similar changes in
GFAP expression in the visual cortex of
hypertensive rats were not observed . -
pubmed
From June 1993 to July 1994 we treated 136 male
patients affected by
dysuria with hematic dosage of
TPS and
PSA , with DRE , transrectal echography and prostatic biopsy using an echograph . -
pubmed
Pim-2 transgene induces
lymphoid tumors , exhibiting potent synergy with
c - myc . -
pubmed
coli O157 isolates from
cattle were verocytotoxigenic as determined by Vero cell assay and DNA hybridization ,
eaeA gene positive , contained a 92 kb plasmid and were thus typical of strains causing
infections in man . -
pubmed
In contrast isolates from
pigs were non - toxigenic ,
eaeA gene negative and did not contain a 92 kb plasmid and would , therefore , be unlikely to be a source of
infection for
man . -
pubmed
This review will provide the reader with a brief overview on some recent studies aimed at understanding the functional role of
homeobox genes in normal
mammalian development as well as their involvement in
congenital malformations and oncogenesis . -
pubmed
This assay also shows that
depudecin induces an intricate network of
actin stress fibers in these cells and in
MG63 osteosarcoma cells and reveals the essential role of the
epoxide and
hydroxyl moieties in
depudecin . -
pubmed
Alterations in the expression of the
breast and ovarian cancer susceptibility gene
BRCA1 may contribute to the development of
mammary and ovarian neoplasia . -
pubmed
The sex - steroid
estrogen modulates cell proliferation of
normal and
neoplastic breast and ovarian epithelial cells , but the role of
estrogen regulation on the expression of
BRCA1 remains to be defined . -
pubmed
In this study ,
estrogen - regulated
BRCA1 expression was examined in
breast and ovarian cancer cells . -
pubmed
Conversely ,
estrogen did not influence expression of
BRCA1 in
HBL-100 cells that lacked the
estrogen receptor , although the constitutive levels of
BRCA1 mRNA ( but not protein ) in these cells were 5- to 30 - fold higher than in other
breast and ovarian cancer cells . -
pubmed
We therefore propose that stimulation of cell proliferation may be a prerequisite for upregulation of
BRCA1 in breast and
ovarian cancer cells . -
pubmed
SMARCC1 ,
SMARCC2 , and
SMARCD1 are assigned to chromosomal regions that are frequently involved in somatic rearrangements in
human cancers . -
pubmed
SMARCD1 was mapped to the critical region of
Allgrove syndrome ; however , no mutation was identified in one
Allgrove syndrome family studied . -
pubmed
QUALITY OF EVIDENCE : Randomized trials establish the efficacy of blood pressure control and
angiotensin - converting enzyme (
ACE ) inhibition in slowing the progression of
chronic renal disease . -
pubmed
Partial correction of
anemia with
iron ,
erythropoietin , or
androgens can improve quality of life and potentially prevent
cardiac disease . -
pubmed
Effects of long - term
angiotensin II AT1 receptor blockade on survival , hemodynamics and cardiac remodeling in chronic
heart failure in
rats . -
pubmed
OBJECTIVE : The beneficial effect of chronic
angiotensin I converting enzyme (
ACE ) inhibition on survival has for long been established in the
rat post -
infarction model of chronic
heart failure (
CHF ) and has subsequently been confirmed in
humans . -
pubmed
CONCLUSIONS : Long - term
angiotensin II AT1 receptor blockade with
irbesartan strongly and dose - dependently increases survival in the
rat model of coronary ligation - induced
CHF . -
pubmed
Long - term
AT1 receptor blockade might thus prove useful and prolong survival in
human CHF . -
pubmed
In
patients with
chronic liver injury , the elevation of serum
ALT levels was mild for about 2 years , but persistent
HGV infection existed . -
pubmed
OBJECTIVE : To investigate the gene mutation of
lipoprotein lipase(
LPL ) of
familial LPL deficiency in China . -
pubmed
This is the first report about the gene mutation of
LPL at this site in
familial LPL deficiency . -
pubmed
Human leucocyte antigen and
insulin gene regions and
nephropathy in
type I diabetes . -
pubmed
This study aimed to examine the role of
human leucocyte antigen and
insulin genes in susceptibility to
nephropathy in
patients with
Type I diabetes . -
pubmed
METHODS : We carried out a genetic association study examining
insulin gene polymorphisms using three large cohorts of patients with
Type I diabetes :
nephropathy ( n = 258 ) , long duration
non - nephropathy ( n = 153 ) and a recently diagnosed ( sporadic )
diabetic cohort ( n = 264 ) . -
pubmed
RESULTS : No significant difference was seen in the distribution of
human leucocyte antigen A , B , C ,
DR ,
DQA1 and
DQB1 haplotypes and alleles between the three
diabetic cohorts . -
pubmed
No significant difference was seen in
insulin ' + ' and ' - ' genotypes and alleles between the three
diabetic cohorts . -
pubmed
CONCLUSIONS / INTERPRETATION :
Human leucocyte antigen and
insulin gene loci are unlikely to have a major role in the susceptibility to
nephropathy in Caucasian patients with
Type I diabetes in the United Kingdom . -
pubmed
Interleukin-10 inhibits
hepatic injury and
tumor necrosis factor - alpha and interferon - gamma mRNA expression induced by
staphylococcal enterotoxin B or lipopolysaccharide in
galactosamine - sensitized
mice . -
pubmed
BACKGROUND / AIMS : Proinflammatory
cytokines including
tumor necrosis factor alpha (
TNF - alpha ) and
interferon gamma (
IFN - gamma ) play a critical role in the pathogenesis of
liver injury induced by lipopolysaccharide ( LPS ) or
staphylococcal enterotoxin B (
SEB ) in
D - galactosamine (
GalN)-sensitized
mice . -
pubmed
The aim of this study was to examine the ability of
interleukin-10 (
IL-10 ) , a recently characterized , highly potent anti - inflammatory mediator , to protect sensitized
mice against
hepatotoxicity induced by SEB or LPS . -
pubmed
RESULTS : Treatment with
IL-10 markedly reduced
serum transaminase activities in a dose - dependent manner and reduced
hemorrhagic liver damage in sensitized
mice exposed to either toxin . -
pubmed
CONCLUSIONS : These findings suggest that
IL-10 is capable of regulating both T cell- and macrophage - mediated
hepatic injury in vivo and that this
cytokine might be useful in the treatment of
acute liver failure . -
pubmed
Sixty - one consecutive adult
patients with
leukaemia ,
primary myelofibrosis or
myelodysplastic syndrome with an
HLA - identical or one antigen mismatched family donor were randomised to allogeneic transplantation with PBPC or BM . -
pubmed
Familial Alzheimer ' s disease presenilin-1 mutants potentiate cell cycle arrest . -
pubmed
The
NF2 tumor suppressor (
merlin /
schwannomin ) has been cloned and extensively analyzed for mutations in patients with different clinical variants of the disease . -
pubmed
Protective effect of
Nocardia opaca lysozyme digest in experimental murine
Candida albicans infections . -
pubmed
BACKGROUND AND OBJECTIVES : We compared the outcome of bone marrow transplantation ( BMT ) from
HLA - identical siblings (
MSD ) and one
HLA - locus mismatched siblings ( PMSD ) in Chinese patients with
hematologic malignancies in terms of transplant - related mortality ( TRM ) and disease relapse to see whether
PMSD can feasibly increase the availability of donors in our population . -
pubmed
Fourteen
patients received BMT from
HLA - A or -B PMSD : 11 of these
patients died after a median of 5.6 months ( range 0.6 - 13.7 months ) due to severe
GVHD ( n=5 ) , graft failure ( n=2 ) ,
bleeding ( n=1 ) , leukemic relapse ( n=2 ) and
thrombotic thrombocytopenic purpura ( n=1 ) . -
pubmed
INTERPRETATION AND CONCLUSIONS : BMT from
PMSD ( especially those with mismatches at
HLA class I loci ) carried a higher risk of
TRM and morbidity than BMT from MSD in our population . -
pubmed
Multiple endocrine neoplasia type 1 (
MEN1 ) gene was identified to be a
tumor suppressor that encodes
menin , playing an important role in the development of
MEN1 - associated tumors . -
pubmed
Somatic
MEN1 gene mutations also were detected in
sporadic non - MEN1 endocrine tumors . -
pubmed
Ten of 18
tumors with 11q allelic loss successfully completed the sequence of the
MEN1 gene coding region and splice junctions , and 3 of 10 ( 30 % )
tumors had no somatic mutation , indicating that other putative tumor - suppressor genes on 11q may contribute to their tumorigenesis . -
pubmed
OBJECTIVE : To investigate clinical manifestations of
relapsing polychondritis and to clarify the significance of
type II collagen antibody in the disease . -
pubmed
CONCLUSION : Though the measurement of
type II collagen antibody titer is not a decisive factor for detection of
relapsing polychondritis , it is useful as one of the complementary factors for the diagnosis , since there is no specific test for this disease . -
pubmed
This
paralysis of DC function could not be triggered in
mice that were deficient in a key
lipoxygenase involved in
LXA ( 4 ) biosynthesis . -
pubmed
Apoptosis induced in
hepatoblastoma HepG2 cells by the proteasome inhibitor
MG132 is associated with
hydrogen peroxide production , expression of
Bcl - XS and activation of
caspase-3 . -
pubmed
Serum
osteoprotegerin levels in
patients after liver transplantation and correlation to bone turnover , bone mineral density and
fracture status . -
pubmed
The aim of this cross sectional study was to evaluate the prevalence of
osteoporosis ,
vertebral fracture status and possible risk factors of
bone loss including serum
osteoprotegerin , a novel key regulator of osteoclast proliferation and activity in the posttransplantation period . -
pubmed
Two - thirds of the
patients had elevated serum cross - laps ,
osteocalcin and
bone specific alkaline phosphatase levels reflecting
increased bone turnover . -
pubmed
Serum
osteoprotegerin (
OPG ) in liver transplant recipients was not significantly different when compared to healthy , matched controls ( 84.7 + /- 6.6 vs. 97.3 + /- 9.4 pg / ml , p = 0.50 ) and similar when fractured / non - fractured or
osteoporotic / non - osteoporotic
patients were compared . -
pubmed
Serum
OPG was not correlated to bone mass or
fracture status in this cross sectional setting but was elevated together with other bone resorption and -formation markers . -
pubmed
Circulating concentration of
adiponectin and its expression in subcutaneous adipose tissue in
patients with highly active antiretroviral therapy - associated
lipodystrophy . -
pubmed
Adiponectin is a adipocytokine that is decreased in
insulin resistant conditions . -
pubmed
We determined serum
adiponenctin and
adiponectin mRNA concentrations in subcutaneous adipose tissue in HIV - positive HAART - treated
patients with ( HAART+LD+ , n = 30 ) and without
lipodystrophy ( HAART+LD- , n = 13 ) . -
pubmed
Both serum
adiponectin and mRNA concentrations correlated closely with features of
insulin resistance , including liver fat content . -
pubmed
[
Chloramphenicol -
trypsin association in local treatment of chronic
phlogosis of the sinal cavity and of the ear ] . -
pubmed
Signaling danger :
toll - like receptors and their potential roles in
kidney disease . -
pubmed
Tubular epithelial cells are among the non - immune cells that express
TLR1 , - 2 , - 3 , - 4 , and - 6 , suggesting that these
TLR might contribute to the activation of immune responses in
tubulointerstitial injury ( e.g. -
pubmed
In addition ,
TLR9 has been shown to be involved in antigen - induced immune complex
glomerulonephritis and
lupus nephritis by regulating humoral and cellular immune responses . -
pubmed
It is likely that
TLR are involved in many if not all types of
renal inflammation . -
pubmed
Here the authors provide an overview on the biology of
TLR , summarize the present data on their expression in the kidney , and provide an outlook for the potential roles of
TLR in
kidney disease . -
pubmed
Endogenous
IL-13 limits humoral responses and injury in experimental
glomerulonephritis but does not regulate Th1 cell - mediated crescentic
glomerulonephritis . -
pubmed
To test the hypothesis that , like the counterregulatory Th2
cytokines IL-4 and
IL-10 , endogenous
IL-13 limits effector Th1 responses in
glomerulonephritis , crescentic
glomerulonephritis was induced in
IL-13+/+ and
IL-13-/-
mice . -
pubmed
Although
IL-13-/-
mice developed increased serum antigen - specific antibody levels , increased glomerular antibody deposition and enhanced switching to the Th1 - associated
IgG2a subclass , they developed a similar degree of crescentic
glomerulonephritis , with similar glomerular T cell / macrophage numbers ,
renal impairment , and
proteinuria . -
pubmed
In immune complex (
apoferritin - induced )
glomerulonephritis , where
renal injury is humorally mediated ,
IL-13-/-
mice developed enhanced humoral immune responses and increased
proteinuria , with increased
IgG2a responses , a more peripheral distribution of
immune complexes , but no alterations in leukocyte recruitment . -
pubmed
These results demonstrate dissociation of
IL-13 's effects in antigen induced
renal disease with little effect on cellular responses but suppressive effects on humoral effectors and switching to
IgG2a . -
pubmed
They indicate a role for
IL-13 in limiting antibody - mediated
renal injury , but not in regulating DTH - like cell - mediated responses in the kidney . -
pubmed
Improved understanding of the signalling pathways involved in
insulin action and the impact of IGF-1 on these processes could lead to a better understanding of the pathophysiology of
insulin resistance associated with
obesity and
type 2 diabetes and the identification of key molecules that could lead to newer and more effective therapeutic agents for treating these common disorders that are already an uprising epidemic of the 21st century . -
pubmed
Pre- and posttreatment with elaterium and
cucurbitacin B reduced
CCl4 -
hepatotoxicity , as shown reduction in the anormally increased
sGPT levels . -
pubmed
The
tumor suppressor protein
p53 mediates stress - induced growth arrest or apoptosis and plays a major role in safeguarding genome integrity . -
pubmed
Mitral valve reconstruction in a compound heterozygote for
sickle cell anemia and
hemoglobin Lepore . -
pubmed
B lymphocyte stimulator ( BLyS ) isoforms in
systemic lupus erythematosus : disease activity correlates better with blood leukocyte
BLyS mRNA levels than with plasma
BLyS protein levels . -
pubmed
Considerable evidence points to a role for
B lymphocyte stimulator (
BLyS ) overproduction in murine and
human systemic lupus erythematosus (
SLE ) . -
pubmed
Nevertheless , the correlation between circulating levels of
BLyS protein and disease activity in
human SLE is modest at best . -
pubmed
Accordingly , we assessed peripheral blood leukocyte levels of
BLyS mRNA isoforms ( full - length
BLyS and
DeltaBLyS ) and plasma
BLyS protein levels in patients with
SLE , and correlated these levels with laboratory and clinical features . -
pubmed
BLyS protein , full - length
BLyS mRNA , and DeltaBLyS mRNA levels were greater in
SLE patients ( n = 60 ) than in
rheumatoid arthritis patients ( n = 60 ) or normal control individuals ( n = 30 ) . -
pubmed
Although full - length
BLyS and
DeltaBLyS mRNA levels correlated significantly with
BLyS protein levels in the
SLE cohort ,
BLyS mRNA levels were more closely associated with serum
immunoglobulin levels and
SLE Disease Activity Index scores than were
BLyS protein levels . -
pubmed
Moreover , changes in
SLE Disease Activity Index scores were more closely associated with changes in
BLyS mRNA levels than with changes in
BLyS protein levels among the 37
SLE patients from whom repeat blood samples were obtained . -
pubmed
Thus , full - length
BLyS and
DeltaBLyS mRNA levels are elevated in
SLE and are more closely associated with disease activity than are
BLyS protein levels . -
pubmed
BLyS mRNA levels may be a helpful biomarker in the clinical monitoring of
SLE patients . -
pubmed
CONCLUSION :
TNF - alpha can induce the
ceramide increase in GMC , which is significant to effect on the
kidney injury of the
rats with
obstructive jaundice , by the means of inducing GMC apoptosis and decreasing the activity of
PC - PLD . -
pubmed
Recognition of hyaluronan released in
sterile injury involves a unique receptor complex dependent on
Toll - like receptor 4 ,
CD44 , and
MD-2 . -
pubmed
Cultured cells exposed to hyaluronan showed a pattern of gene induction that mimics the response seen in
mouse skin after sterile
injury with an increase in molecules such as
transforming growth factor - beta2 and
matrix metalloproteinase-13 . -
pubmed
Explanation for the unique response to hyaluronan was provided by observations that a lack of
TLR4 or
CD44 in
mice diminished the response to
sterile injury , and together with
MD-2 , was required for responsiveness to hyaluronan in vitro . -
pubmed
CD34(+ ) cell recovery was higher with Sepax ( 86+/-11.6 % ) than with HES ( 81.5+/-12.5 % ) and
TB ( 82.0+/-17.7 % ) ( P<0.008 and & lt;0.0001 , respectively ) and results with
HES and
TB were not significantly different ( P=0.7 ) . -
pubmed
Synergistic antitumor effect of
CXCL10 with
hyperthermia . -
pubmed
In the present study , we try to investigate whether the combination therapy of
hyperthermia , a physical antiangiogenic modality , with
CXCL10 would completely eradicate the established
solid tumors . -
pubmed
Mice were treated with either
CXCL10 at 25 microg / kg once a day for 20 days ,
hyperthermia was given twice ( at 42 degrees C for 1 h , on day 6 and 12 after the initiation of
CXCL10 ) , or together . -
pubmed
RESULTS : The results showed that
CXCL10 and
hyperthermia inhibited the growth of
Meth A fibrosarcoma and interestingly , the combination therapy enhanced the antiangiogenic effects and completely eradicated the established
solid tumors . -
pubmed
Histological examination revealed that
CXCL10 +
hyperthermia led to increased induction of apoptosis ,
tumor necrosis , and elevated lymphocyte infiltration compared with the controls . -
pubmed
Effect of
lipid - bound
apoA - I cysteine mutants on
lipopolysaccharide - induced
endotoxemia in
mice . -
pubmed
Here , we reconstituted recombinant
HDLs ( named rHDLwt , rHDL52 , rHDL74 , rHDL107 , rHDL129 ,
rHDL173 ,
rHDL195 , and
rHDL228 ) by mixing wild type or those mutants with
dipalmitoyl phosphatidylcholine and examined their in vivo effects on LPS - induced
endotoxemia in
mice . -
pubmed
Administration of rHDL74 to
mice injected with LPS also led to a decrease of plasma
IL-6 , protection of lung against
acute injury , and attenuation of endotoxin - induced clinical symptoms in
mice , compared with controls injected with LPS only . -
pubmed
However , injection of rHDL228 significantly increased plasma concentration of
TNF - alpha and exacerbated LPS - induced
lung injury . -
pubmed
[ Wenyang Huoxue Recipe up - regulates the expression of
angiopoietin-1 mRNA in
rats with chronic
aristolochic acid nephropathy ] . -
pubmed
OBJECTIVE : To investigate the effects of Wenyang Huoxue Recipe ( WRHXR ) , a compound traditional Chinese herbal medicine for warming yang and promoting blood flow , on the expression of
angiopoietin mRNA in
rats with chronic
aristolochic acid nephropathy induced by
Caulis Aristolochia Manshuriensis ( CAM ) decoction , and to explore the protection mechanism of
WYHXR against
kidney damage . -
pubmed
Renal pathology showed that
renal damage in
WYHXR - treated group was significantly reduced as compared with the CAM group . -
pubmed
RESULTS : In
OA cells ,
TGF - beta1 significantly reduced the percentage of hypo - diploid chondrocytes , as well as the percentage of internucleosomal DNA breakage . -
pubmed
MKP-1 expression did not show significant modulation in
OA or normal chondrocytes . -
pubmed
However ,
PP2A activity was differentially modulated in normal and
OA chondrocytes . -
pubmed
In
OA chondrocytes ,
PP2A activity was not altered by
TGF - beta1 stimulation ; however in normal chondrocytes
PP2A activity was significantly activated by
TGF - beta1 . -
pubmed
Caseinolytic protease : a protein vaccine which could elicit serotype - independent protection against invasive
pneumococcal infection . -
pubmed
In this study , we evaluated the protective efficacy of immunizing
mice with
caseinolytic protease (
ClpP ) protein antigen whose gene sequences were shown to be highly conserved in different strains of
Streptococcus pneumoniae in an invasive - disease model (
intraperitoneal infection model ) , and protection against invasive challenge with 12 different serotypes of
S. - pubmed
Our findings demonstrated that active immunization with
ClpP and passive immunization with antibodies specific for
ClpP could elicit serotype - independent protection effectively against invasive
pneumococcal infection . -
pubmed
Rac and
Rho driving
tumor invasion : who 's at the wheel ? -
pubmed
Genome - wide analysis of regulators of
Rho - family small GTPases has identified critical elements that control the morphology and invasive behavior of
melanoma cells . -
pubmed
Inhibition of
mTOR in
kidney cancer . -
pubmed
The
mammalian target of rapamycin (
mTOR ) has been shown to be an important target mechanism in the treatment of
renal cell carcinoma (
RCC ) . -
pubmed
There is now compelling clinical evidence for the effectiveness of targeting
mTOR in the treatment of
RCC . -
pubmed
Corneal verticillata after dual anti -
epidermal growth factor receptor and anti -
vascular endothelial growth factor receptor 2 therapy (
vandetanib ) for
anaplastic astrocytoma . -
pubmed
RESULTS : A 48 - year - old female
patient with a history of
anaplastic astrocytoma status post resection , external beam radiation , and chemotherapy presented with
glare symptoms , decreased contrast sensitivity , and increased
lacrimation after approximately 12 months of therapy with the anti -
epidermal growth factor receptor (
EGFR ) and anti -
vascular endothelial growth factor receptor 2 protein tyrosine kinase inhibitor ,
vandetanib . -
pubmed
CONCLUSIONS :
Vandetanib (
ZD6474 ) , a
protein tyrosine kinase inhibitor with dual anti -
EGFR and anti -
vascular endothelial growth factor receptor 2 action , may have contributed to the formation of
corneal verticillata in our
patient . -
pubmed
Inhibition of
EGFR , which is involved with corneal epithelial cell migration and
wound healing , may play a role in the pathogenesis underlying
corneal vortex keratopathy and ocular surface conditions with significant epithelial turnover . -
pubmed
Comprehensive characterization of the DNA amplification at 13q34 in
human breast cancer reveals
TFDP1 and
CUL4A as likely candidate target genes . -
pubmed
Tumors with 13q34 amplification were associated with high grade ,
estrogen receptor negativity , and expression of
EGFR ,
CCNE ,
CK5 , and
P - Cadherin , among other basal cell markers . -
pubmed
Moreover , we have confirmed that
tumors with 13q34 amplification significantly overexpress
CUL4A and
TFDP1 proteins . -
pubmed
Tumors overexpressing either
CUL4A or
TFDP1 were associated with
tumor proliferation and cell cycle progression markers . -
pubmed
CONCLUSIONS : We conclude that 13q34 amplification may be of relevance in
tumor progression of basal - like
breast cancers by inducing overexpression of
CUL4A and
TFDP1 , which are both important in cell cycle regulation . -
pubmed
A potential regulatory single
nucleotide polymorphism in the promoter of the
Klotho gene may be associated with
essential hypertension in the Chinese Han population . -
pubmed
BACKGROUND :
Mice with defects in the
Klotho gene exhibit multiple aging phenotypes including
arteriosclerosis . -
pubmed
We hypothesised that the G-395A polymorphism in the promoter region of the
human Klotho gene may contribute to the prevalence of
Essential Hypertension (
EH ) . -
pubmed
METHODS : We investigate whether the G-395A polymorphism of
Klotho is associated with
EH in a population consisting of 215
patients with
EH and 220 non -
hypertensive subjects . -
pubmed
CONCLUSIONS : The G-395A polymorphism of the
human Klotho gene is associated with
EH and may be a potential regulatory site . -
pubmed
TRPV1 involvement in inflammatory tissue
fibrosis in
mice . -
pubmed
We examined whether absence or blocking of
transient receptor potential vanilloid subtype 1 (
TRPV1 ) affects the level of
inflammation and
fibrosis /
scarring during healing of injured tissue using an alkali
burn model of cornea in
mice . -
pubmed
A
cornea burn was produced with 1 N
NaOH instilled into one eye of
TRPV1-/- ( KO ) ( n = 88 ) or
TRPV1+/+ ( n = 94 )
mice . -
pubmed
Examinations of the corneal surface and eye globe size suggested that the loss of
TRPV1 suppressed
inflammation and
fibrosis / scarring after alkali
burn , and this was confirmed by histology , IHC , and gene expression analysis . -
pubmed
In conclusion , absence or blocking of
TRPV1 suppressed
inflammation and
fibrosis / scarring during healing of alkali - burned
mouse cornea . -
pubmed
TRPV1 is a potential drug target for improving the outcome of inflammatory / fibrogenic
wound healing . -
pubmed
Long - term results of surgery plus
fibrin sealant for
anal fistula . -
pubmed
AIM : The long - term recurrence rate of
fibrin glue treatment was analysed in
patients with
trans - sphincteric cryptoglandular fistula operated by a two - phase procedure : ( i ) fistulectomy with seton placement ; ( ii )
fibrin sealant ( Tissucol Duo , Baxter ) insertion in the track . -
pubmed
[ Study of resistance to chemotherapy mediated by
ABC transporters in biopsies of
glioblastoma multiforme ] . -
pubmed
CONCLUSIONS : We propose that
Mrp1 activity is responsible for the chemo - resistance of the
glioblastoma multiforme and inhibition of this transporter could represent a plausible strategy for the treatment . -
pubmed
The absence of
OPN in vivo reduces
dermal scarring . -
pubmed
This suggests that
OPN is involved in
scar formation ; however , how
OPN exerts these pro - scarring effects is unknown . -
pubmed
CONCLUSION :
OPN is associated with
scar and exerts pro - scarring effects by increasing cellular migration , adhesion , proliferation , and contractility of
human dermal fibroblasts . -
pubmed
OPN may be useful for promoting closure of non - healing wounds and the
OPN specific aptamer , R3 , may be useful for preventing
fibrosis . -
pubmed
Current approaches to the management of
Her2 - negative metastatic
breast cancer . -
pubmed
Knowledge of the
estrogen receptor (
ER ) ,
progesterone receptor (
PR ) , and
Her2 receptor status of the metastatic
tumor has become critical to determining the optimal treatment strategy in the metastatic setting as targeted therapeutic approaches are developed . -
pubmed
So - called ' triple - negative '
breast cancer - lacking
ER ,
PR , and
Her2 overexpression - remains a major challenge . -
pubmed
The role of
foxp3 - expressing regulatory T cells and T helpers in immunopathogenesis of
multidrug resistant pulmonary tuberculosis . -
pubmed
It has been shown that the leading part in immune suppression at infiltrative , dissemination , and
fibrosis - cavity pulmonary tuberculosis is played by natural regulatory
CD4(+)
CD25(+)
Foxp3(+)-T lymphocytes . -
pubmed
It has been demonstrated that in patients with fibrocavernous and infiltrative form of the disease and
drug - resistant pulmonary tuberculosis the number of
CD4(+)
CD25(-)
Foxp3(+)-regulatory T cells was increasing . -
pubmed
tuberculosis , an increased number of
CD3(+)
CD4(+)
CD25(- ) T helpers is determined by the pathogenic features of the development of the
tuberculosis infection and is connected with the activation of Th1 - dependent immune response . -
pubmed
Relevance of
vascular peroxisome proliferator - activated receptor gamma coactivator-1alpha to molecular alterations in
atherosclerosis . -
pubmed
Expression of
PGC-1alpha ,
SIRT1 ,
PPARgamma and
adiponectin was reduced ( P<0.05 ) in aorta from
atherosclerotic rabbits . -
pubmed
The observed results suggest that
PGC-1alpha could be considered to be a link between the main
atherosclerotic processes (
endothelial dysfunction , oxidation and
inflammation ) and alterations of other factors involved in vascular wall integrity , such as
SIRT1 ,
PPARgamma and
adiponectin . -
pubmed
OBJECTIVES :
Tacrine was the first
acetylcholinesterase inhibitor approved for the treatment of
Alzheimer disease . -
pubmed
The significant delay in
wound closure exhibited in
diabetic wounds was mainly attributed to alterations in the granulation tissue formation and resolution , involving defects in
wound bed maturation , vascularisation , inflammatory response and
collagen deposition . -
pubmed
In the new model , a cell - based
wound therapy consisting of the application of plasma - derived
fibrin dermal scaffolds containing fibroblasts consistently improved the healing response by triggering granulation tissue maturation and further providing a suitable matrix for migrating keratinocytes during
wound re - epithelialisation . -
pubmed
Serum
gamma - glutamyltransferase activity and
acute coronary syndromes . -
pubmed
NKX2 - 1 /
TTF-1 : an enigmatic oncogene that functions as a double - edged sword for
cancer cell survival and progression . -
pubmed
Emerging evidence indicates that
NKX2 - 1 , a homeobox - containing transcription factor also known as
TTF-1 , plays a role as a " lineage - survival " oncogene in
lung adenocarcinomas . -
pubmed
In T cell
acute lymphoblastic leukemia , gene rearrangements lead to aberrant expression of
NKX2 - 1 /
TTF-1 . -
pubmed
Despite accumulating evidence supporting its oncogenic role , it has become apparent that
NKX2 - 1 /
TTF-1 expression also has biological and clinical functions in the opposite direction that act against
tumor progression . -
pubmed
A road map to comprehensive
androgen receptor axis targeting for castration - resistant
prostate cancer . -
pubmed
The persistent significance of the
androgen receptor (
AR ) axis in
CRPC was recently validated by the clinical efficacy of
androgen synthesis inhibitors (
abiraterone ) and novel , second - generation
AR antagonists (
enzalutamide ) . -
pubmed
A treatment paradigm of comprehensive
AR axis targeting at multiple levels (
androgen synthesis , metabolism , and action ) and at all relevant sites ( gonadal , adrenal , intratumoral ) simultaneously at the time of initiation of endocrine therapy ( instead of the current approach of sequentially adding one agent at a time and only after disease progression ) deserves examination in clinical trials to explore whether maximal first - line
AR axis suppression via combination therapy can achieve maximal induction of
cancer cell apoptosis ( before they have the chance to adapt and evolve into
CRPC ) and thus , improve
patient outcomes . -
pubmed
Although
IFN - gamma is required for resolution of
Listeria monocytogenes infection , the identities of the
IFN - gamma - responsive cells that initiate the process remain unclear . -
pubmed
Itgax - cre(+)
Ifngr1(f / f )
mice with selective
IFN - gamma unresponsiveness in
CD8alpha(+ ) dendritic cells displayed increased susceptibility to
infection . -
pubmed
We also found that
Itgax - cre(+)
Ifngr1(f / f )
mice survived
infection with low - dose
Listeria as the result of a second wave of
IL-12 produced by
Ly6C(hi ) monocytes . -
pubmed
Diagnostic sensitivity was demonstrated by measuring significantly higher Ld from a human
colon cancer cell line (
HT29 control vector ) than a less aggressive variant (
epidermal growth factor receptor knockdown ) . -
pubmed
Rice fortified with
iron given weekly increases
hemoglobin levels and reduces
anemia in infants : a community intervention trial . -
pubmed
The objective of this study was to evaluate the impact of
rice fortified with
iron ( Ultrarice ) on
hemoglobin and
anemia prevalence compared with standard household rice . -
pubmed
In this intervention ,
rice fortified with
iron given weekly was effective in increasing
hemoglobin levels and reducing
anemia in infants . -
pubmed
Anti -
CCR4 monoclonal antibody mogamulizumab for the treatment of
EBV - associated T- and
NK - cell lymphoproliferative diseases . -
pubmed
Furthermore ,
CCR4 was expressed on
EBV - infected cells in 8 of 17
patients with
EBV - associated T / NK - LPDs . -
pubmed
Interestingly ,
CCR4 was positive in 5 of 5
patients with hydroa vacciniforme , a
photodermatosis caused by the clonal expansion of
EBV - infected gammadeltaT cells . -
pubmed
could reduce the water content of the spinal cord , and suppress the expression of
aquaporin-4 and
glial fibrillary acidic protein after
spinal cord injury . -
pubmed
This suggests that the mechanism by which
melatonin alleviates the damage to the spinal cord by
edema might be related to the expression of
aquaporin-4 and
glial fibrillary acidic protein . -
pubmed
The expansion of the GGGGCC hexanucleotide repeat in the non - coding region of the Chromosome 9 open - reading frame 72 (
C9orf72 ) gene is the most common genetic cause of
frontotemporal dementia (
FTD ) and
amyotrophic lateral sclerosis (
ALS ) . -
pubmed
Immunostaining of brain sections from patients with C9orf72
ALS showed that
poly - GR was colocalized with a mRNA - binding protein ,
hnRNPA1 . -
pubmed
Our results demonstrate that impaired protein translation mediated by
poly - PR and poly - GR peptides plays a role in
neurotoxicity and reveal that the pathways altered by the poly - dipeptides - mRNA complexes are potential therapeutic targets for treatment of C9orf72
FTD /
ALS . -
pubmed
AMPKalpha1 overexpression alleviates the hepatocyte model of
nonalcoholic fatty liver disease via inactivating
p38MAPK pathway . -
pubmed
The results displayed that the
AMPKalpha1 overexpression suppressed lipid accumulation in the cytoplasm , decreased
triglyceride levels , maintained the survival of
steatotic hepatocyte model with decreased cell apoptosis and increased survival rate . -
pubmed
These results indicated that
AMPKalpha1 may serve as a novel target for treatment of
NAFLD . -
pubmed
Prognostic evaluation of
VEGFA genotypes and haplotypes in a cohort of Brazilian women with non metastatic
breast cancer . -
pubmed
Vascular Endothelial Growth Factor (
VEGF ) mediates angiogenesis , which is crucial for
tumor development and progression . -
pubmed
The present study aimed to evaluate the impact of
VEGFA gene polymorphisms rs699947 , rs833061 , rs1570360 , rs2010963 and rs3025039 on
breast cancer features and prognosis . -
pubmed
VEGFA genotyping may add to prognostic evaluation of
breast cancer , with rs699947 being the most likely to contribute . -
pubmed
Serum and Plasma Levels of
Vascular Endothelial Growth Factors in Relation to Quality of
Glucose Control , Biomarkers of
Inflammation , and
Diabetic Nephropathy . -
pubmed
Levels of
vascular endothelial growth factors (
VEGF ) are regulated in a complex network of adipokines ,
glucose control , and low grade
inflammation together with activated platelets , leucocytes , and
endothelial dysfunction . -
pubmed
Increased levels of
VEGF are associated with enhanced angiogenesis and impaired repair mechanisms of
vascular lesions in endorgans . -
pubmed
Little is known about the interaction of systemic
VEGF levels with quality of
diabetes control , biomarkers of
inflammation , and
diabetic nephropathy . -
pubmed
Moreover , it is unclear , whether serum and plasma
VEGF levels are similarly suited to reflect risk associated with VEGF.In this case control study , we analyzed these parameters in serum and plasma of age and sex matched controls without
diabetes ( n=99 ) and
type 2 diabetes ( n=302 ) . -
pubmed
Serum
VEGF - A was significantly increased in
patients with
T2DM while plasma levels were in the same range as for controls . -
pubmed
T2DM was associated with significantly higher levels of
hsCRP ,
ALAT , and
albumin /
creatinine ratio . -
pubmed
Correlation analysis revealed a significant relationship between
VEGF - A ,
HbA1c ,
inflammation , and
diabetic nephropathy . -
pubmed
Our results indicate that increased
VEGF - A levels in
T2DM significantly depend on quality of HbA1c control . -
pubmed
Collagenases and
gelatinases regulate many physiological processes and are involved in the pathogenesis and progression of various disease states , such as
osteoarthritis ,
renal fibrosis , and
atherosclerosis . -
pubmed
Biological significance of
PinX1 telomerase inhibitor in
esophageal carcinoma treatment . -
pubmed
PinX1 can inhibit
human telomerase activity and the expression of
hTERT mRNA , reduce
tumor cell growth and induce apoptosis . -
pubmed
Altered DNA Methylation of Long Noncoding RNA
H19 in
Calcific Aortic Valve Disease Promotes Mineralization by Silencing
NOTCH1 . -
pubmed
RESULTS : We documented that lncRNA
H19 (
H19 ) was increased in
calcific aortic valve disease . -
pubmed
CONCLUSIONS : These findings indicate that a dysregulation of DNA methylation in the promoter of
H19 during
calcific aortic valve disease is associated with a higher expression of this lncRNA , which promotes an osteogenic program by interfering with the expression of
NOTCH1 . -
pubmed
INTERVENTIONS : Both
patients received
brincidofovir for the treatment of
cytomegalovirus infection with mutation of
UL-97 . -
pubmed
They presented an
acute kidney injury without any occurrence of other clinical event such as introduction of
nephrotoxic drug , graft rejection ,
urinary tract obstruction or
infection , and
calcineurin inhibitor
overdosage . -
pubmed
MATE2 Expression Is Associated with
Cancer Cell Response to
Metformin . -
pubmed
PURPOSE : Here we sought to determine if there is an association between the effects of
metformin on inhibiting
oxygen consumption , proliferation and expression of
OCTs and
MATEs in a panel of 19
cancer cell lines . -
pubmed
EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the
FBW7 tumor suppressor . -
pubmed
However , the detailed molecular mechanism(s ) underlying the post - transcriptional regulation of
EglN2 and its potential role in Triple Negative
Breast Cancer (
TNBC ) remains largely unclear . -
pubmed
By using C3Tag
transgenic mice and
tumor - derived
C3Tag cell line , here we report that
EglN2 contributes to
TNBC tumor progression and genetic knockout of
EglN2 improves C3Tag
mice survival from
tumor progression . -
pubmed
Mechanistically , we further show that
FBW7 , an E3 ligase complex component that is frequently downregulated in
TNBC , negatively regulates
EglN2 protein stability . -
pubmed
Together , our study reveals that
EglN2 might act as an
FBW7 ubiquitin ligase substrate contributing to
TNBC . -
pubmed
Vitamin D receptor gene polymorphisms among Emirati patients with
type 2 diabetes mellitus . -
pubmed
Among these , the
Vitamin D receptor (
VDR ) gene is a good candidate for
T2DM susceptibility . -
pubmed
The aim of this study was to investigate the association between
VDR polymorphisms and
T2DM among a representative sample of the Emirati population . -
pubmed
In regards to
T2DM - related
metabolic complications , the AG and GG genotypes of rs731236 were significantly associated with higher total
cholesterol ( p=0.011 ) and
LDL -
cholesterol ( p=0.009 ) levels in the patients with
T2DM . -
pubmed
The frequency of AAT and GGC haplotypes was also different between groups ( p=0.014 ; p=0.032 , respectively ) , implying that these haplotypes of the
VDR gene are associated with the susceptibility to
T2DM in the Emirati population . -
pubmed
To conclude , an association between SNPs in the
VDR gene ( except for rs731236 ) and
T2DM per se was demonstrated . -
pubmed
The rs731236 variant was shown to be associated with high
cholesterol and
LDL -
cholesterol levels in
T2DM patients , while rs1544410 was associated with lower BMI and lower
LDL cholesterol levels . -
pubmed
Our results imply that alleles and haploypes of the
VDR gene are associated with the susceptibility to
T2DM in the Emirati population . -
pubmed
There were no differences in endothelialization ,
vascular injury , or
inflammation between the new test stents and BMS , although the new stents showed higher
fibrin deposition ( P = .0006 ) . -
pubmed
Furthermore , this method could detect multiple
TFs in
human colon cancer DLD-1 cells and reflect the variation in their cellular levels after stimulation . -
pubmed
OBJECTIVE : This study aims to detect the role of DNA methylation in
norepinephrine transporter (
NET ) gene promoter region on the association between
depression and
hypertension . -
pubmed
RESULTS : For each
CpG site and the average value of nine
CpG sites , there were no significant differences in DNA methylation of the
NET gene promoter between healthy controls and patients with
depression or
hypertension . -
pubmed
CONCLUSION : Our study indicates that DNA methylation levels of nine
CpG sites in
NET gene promoter region are not associated with
depression and
hypertension . -
pubmed
Deficient
Insulin - mediated Upregulation of the
Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased
Adenosine in
Diabetic Glomerulopathy . -
pubmed
Deficient
insulin signaling is a key event mediating
diabetic glomerulopathy . -
pubmed
Therefore , we tested a link between
insulin deficiency and dysregulated activity of the
equilibrative nucleoside transporters (
ENTs ) responsible for controlling extracellular levels of
adenosine . -
pubmed
In glomeruli of
streptozotocin - induced
diabetic rats ,
insulin deficiency leads to decreased activity of
ENT2 and chronically increased extracellular levels of
adenosine . -
pubmed
Treatment of
diabetic rats with
adenosine deaminase attenuated both the glomerular loss of
nephrin and
proteinuria . -
pubmed
In conclusion , we evidenced
ENT2 as a target of
insulin signaling and sensitive to dysregulation in
diabetes , leading to chronically increased extracellular
adenosine levels and thereby setting conditions conducive to
kidney injury . -
pubmed
The rs1024611 in the
CCL2 gene and risk of
gynecological cancer in Asians : a meta - analysis . -
pubmed
BACKGROUND : The -2518A / G ( rs1024611 ) polymorphism of the
CCL2 (
C - C motif chemokine ligand 2 ) , also known as
MCP-1 (
monocyte chemotactic protein-1 ) gene , has been reported to be associated with increased
gynecological cancer risk , but the results are conflicting . -
pubmed
METHODS : In this analysis , 1089 cases and 1553 controls from six publications were used to investigate the association between
CCL2 - 2518A / G ( rs1024611 ) polymorphism and the risk of
gynecological cancer with a meta - analytic approach . -
pubmed
Six articles focused on the association between
CCL2 - 2518A / G ( rs1024611 ) polymorphism , and
gynecological cancer risk was selected and data were extracted . -
pubmed
RESULTS : The meta - analysis showed that
CCL2 - 2518A / G ( rs1024611 ) polymorphism is associated with risk of
gynecological cancer ( GG vs AG + AA , OR = 1.55 , 95%CI = 1.07 - 2.24 , P & lt ; 0.05 ; AA vs GG , OR = 0.59 95%CI = 0.38 - 0.92 , P & lt ; 0.05 ) . -
pubmed
CONCLUSIONS : Our data demonstrated the
CCL2 - 2518A / G ( rs1024611 ) polymorphism is significantly associated with risk of
gynecological cancer , and the association differs by ethnicity . -
pubmed
The efficacy of
erlotinib treatment for advanced
non - small cell lung cancer (
NSCLC ) is due to its action as an
epidermal growth factor receptor tyrosine kinase inhibitor (
EGFR - TKI ) . -
pubmed
Sixty Han Chinese advanced
non - small cell lung cancer patients received
erlotinib monotherapy and , for each participant , 76 candidate genes ( related to
EGFR signaling , drug metabolism and drug transport pathways ) were sequenced and analyzed . -
pubmed
Rs1064796 in
CYP4F11 and rs10045685 in
UGT3A1 were significantly associated with
adverse drug reaction . -
pubmed
Tumor necrosis factor - alpha -308G / A gene polymorphism and novel biomarker profiles in
patients with
Takayasu arteritis . -
pubmed
Tumor necrosis factor - alpha (
TNF - alpha ) is a
cytokine with pleomorphic actions and plays a pivotal role in
inflammation ; the serum level of
TNF - alpha is genetically determined . -
pubmed
However , the literature lacks adequate information on the association of
TNF - alpha polymorphisms with
TA . -
pubmed
Hence , the present study investigates the contribution of
TNF - alpha polymorphism toward the complex etiology of
TA . -
pubmed
The genetic study ( available for 57
TA patients and 36 controls ) revealed that the
TNF - alpha -308A allele was overrepresented in the
TA patients ( 12 % vs 7 % ) . -
pubmed
Two studies by Phallen and colleagues and Anagnostou and colleagues correlated sensitive measures of ctDNA with clinical responses to
tyrosine kinase inhibitors ( TKI ) and immune checkpoint inhibitors , respectively , in
patients with
non - small cell lung cancer (
NSCLC ) . -
pubmed
The mRNA expression levels of
IL-1beta ,
IL-6 ,
IL-8 ,
IFNs ,
TNF - alpha ,
Mx , and
OASL were significantly upregulated during the
viral infection . -
pubmed
Identification of personalized antihypertensive treatments is a key for better BP management Objective : This review aimed to elucidate aspects of rational drug design and other methods to develop better
hypertension management Results : Among
hypertension - related signaling mechanisms , the
renin -
angiotensin -
aldosterone system is the leading genetic target for
hypertension treatment . -
pubmed
Autosomal recessive primary microcephaly 5 (
MCPH5 ) is caused by pathogenic variants in
ASPM . -
pubmed
Ten ( 8.6 % ) had a
positive family history , despite a few studies on
RB1 gene . -
pubmed
Correlations Among Subcutaneous
Immunoglobulin Dosage ,
Immunoglobulin G Serum Pre - infusional Levels and Body Mass Index in Primary
Antibody Deficiency Patients : A Pooled Analysis from the SHIFT / IBIS Studies . -
pubmed
BACKGROUND AND OBJECTIVE : In recent years , two Italian non - interventional studies evaluated subcutaneous
immunoglobulin (
SCIG ) treatment in
patients affected by
primary antibody deficiency (
PAD ) . -
pubmed
CONCLUSIONS : These findings support the concept that the cumulative monthly dose of SCIG and the dose of SCIG per kilogram of body weight affect
IgG trough levels in
PAD patients , irrespective of BMI . -
pubmed
We have previously developed a
4 - 1BB / CD3 - zeta - costimulated CAR - T cells against
CD19 ( CART19 ) for adult
acute lymphoblastic leukemia (
ALL ) . -
pubmed
However , CART19 had no obvious effects on either the mean body mass or the blood cell counts , and no
cytokine release syndrome and
graft versus host disease were observed . -
pubmed
Our study shed light on evaluation and supervision strategies for
CAR - T products for the treatment of
hematological diseases or
leukemia . -
pubmed
The radiosynthesis , quality control , and preliminary biological evaluation of
[ 64Cu ] NOTA - PA1 have broaden the application of
radiolabeled octreotide for SSTRs imaging , which could act as a potential multisubtypes targeted radiotracer for imaging
SSTRs - positive
tumors . -
pubmed
Cerebral Ischemia -
Reperfusion Injury :
Lysophosphatidic Acid Mediates
Inflammation by Decreasing the Expression of
Liver X Receptor . -
pubmed
In this study , we evaluated the expression of the
liver X receptor (
LXR ) and
nuclear factor kappa B (
NFkappaB ) by Western blotting , quantified the levels of
IL-1beta ,
IL-6 ,
TNF - alpha , and
LPA by ELISA , and evaluated apoptosis and
infarct by TUNEL ( terminal deoxynucleotidyl transferase ( TdT )
dUTP nick - end labeling ) and
TTC (
triphenyltetrazolium chloride ) staining respectively in
Sprague - Dawley ( SD ) rats after
middle cerebral artery occlusion (
MCAO ) . -
pubmed
The levels of
LPA , an extracellular signaling molecule , increased after
ischemia and caused
neurological injury effect , decreased the expression level of
LXR , and increased the expression level of
inflammatory factors (
IL-1beta ,
IL-6 , and
TNF - alpha ) via the
NFkappaB signaling pathway . -
pubmed
In conclusion , we speculate that the inhibition of
LPA generation and administration of
LXR agonist may be explored as potential
cerebral infarction treatment strategies . -
pubmed
Tcf4 has been linked to
autism ,
schizophrenia , and
Pitt - Hopkins Syndrome (
PTHS ) in
humans , suggesting a role for
Tcf4 in brain development and importantly cortical development . -
pubmed
Deletion of
Tcf4 results in mis - specification of the cortical neurons ,
malformation of the corpus callosum and anterior commissure , and
hypoplasia of the hippocampus . -
pubmed
Furthermore , many genes that are differentially expressed after
Tcf4 ablation are linked to other
neurodevelopmental disorders . -
pubmed
Taken together , we show that correct brain development and neuronal differentiation are severely affected in
Tcf4 mutants , phenocopying morphological
brain defects detected in
PTHS patients . -
pubmed
In the
children with
LN , the plasma levels of miR-145 and miR-183 were negatively correlated with SLEDAI score , anti - dsDNA antibody , Scr , and BUN ( P<0.05 ) and were positively correlated with
complement C3 ,
complement C4 , and
Alb ( P<0.05 ) . -
pubmed
Receptor for Advanced Glycation End Products is Involved in Platelet Hyperactivation and Arterial
Thrombosis during
Chronic Kidney Disease . -
pubmed
In this study , we analyzed the impact of
CKD on platelet function and
arterial thrombosis , and the potential role of
RAGE in this process . -
pubmed
METHODS : Twelve weeks after induction of
CKD in
mice , platelet function and time to complete
carotid artery occlusion were analyzed in four groups of
animals ( sham - operated ,
CKD ,
apolipoprotein E [
Apoe]-/- , and
Apoe-/-/Ager-/-
mice ) . -
pubmed
RESULTS : Analysis of platelet function from whole blood and platelet - rich plasma showed hyperactivation of platelets only in
CKD Apoe-/-
mice . -
pubmed
In vivo ,
CKD significantly reduced carotid occlusion times of
Apoe-/-
mice ( 9.2 + - 1.1 vs. 11.1 + - 0.6 minutes for sham , p < 0.01 ) . -
pubmed
In contrast ,
CKD had no effect on occlusion times in
Apoe-/-/
Ager-/-
mice . -
pubmed
Moreover ,
carotid occlusion in
Apoe-/-
CKD mice occurred significantly faster than in
Apoe-/-/
Ager-/-
CKD mice ( p < 0.0001 ) . -
pubmed
CONCLUSION : Our results show that
CKD induces platelet hyperactivation , accelerates
thrombus formation in a
murine model of
arterial thrombosis , and that
RAGE deletion has a protective role . -
pubmed
We propose that
RAGE ligands binding to
RAGE is involved in
CKD - induced
arterial thrombosis . -
pubmed
ARNTL2 promotes
pancreatic ductal adenocarcinoma progression through
TGF /
BETA pathway and is regulated by miR-26a-5p . -
pubmed
Increasing evidence shows that
aryl hydrocarbon receptor nuclear translocator like 2 (
ARNTL2 ) plays crucial roles in tumorigenesis of
multiple tumors . -
pubmed
However , the expression status and functions of
ARNTL2 in
PDAC remain elusive . -
pubmed
Here we showed that
ARNTL2 expression was markedly upregulated in
PDAC tissues and cell lines . -
pubmed
Knockdown of
ARNTL2 could suppress motility and invasive ability of
PDAC cells in vitro , as well as
tumor development in vivo . -
pubmed
In addition , microRNA-26a-5p ( miR-26a-5p ) was identified as the crucial specific arbitrator for
ARNTL2 expression and the expression of miR-26a-5p was inversely correlated with
ARNTL2 expression in
PDAC tissues . -
pubmed
Functionally , elevated expression of miR-26a-5p was found to inhibit the proliferation , migration , and invasion of
PDAC cells in vitro , while
ARNTL2 increased expression could partially abolish the suppressive effect of miR-26a-5p . -
pubmed
Mechanism study indicated that elevated expression of miR-26a-5p suppressed
TGF /
BETA signaling pathway by targeting
ARNTL2 in
PDAC cells . -
pubmed
In conclusion , our data suggested that
ARNTL2 acted as an oncogene to regulate
PDAC growth . -
pubmed
MiR-26a-5p /
ARNTL2 axis may be a novel therapeutic candidate target in
PDAC treatment . -
pubmed
Factors Associated with
Hepatitis B Surface Antigen Kinetics and Responses in
Pegylated Interferon Alpha-2a Monotherapy for
Patients with
Chronic Hepatitis B. Objective
Pegylated - interferon monotherapy is the standard treatment for
patients with
chronic hepatitis B ; however , the factors associated with its therapeutic effects remain unclear . -
pubmed
Conclusion These findings suggest that the baseline
HBsAg level ,
HBsAg kinetics at 12 weeks of treatment , and
ALT increase during treatment are important factors contributing to the
HBsAg response in
pegylated interferon alpha-2a monotherapy for
patients with
chronic hepatitis B. -
pubmed
Ferritins purified from
horse spleen and from
rat liver , kidney , heart and
hepatoma were analyzed by quantitative
polyacrylamide gel electrophoresis . -
pubmed
However , the estimated charges on
rat liver , kidney and
hepatoma monomers ( 30 - 38 net protons per molecule ) differed from that of spleen monomer ( 51 net protons per molecule ) while the larger
rat heart
ferritin also had a greater charge ( 83 net protons ) than the smaller ( 40 net protons ) . -
pubmed
Expression of
T - antigen on polyagglutinable erythrocytes and
carcinoma cells : preparation of T - activated erythrocytes ,
anti - T lectin ,
anti - T absorbed
human serum and purified
anti - T antibody . -
pubmed
The combined effect of radiotherapy and
neuraminidase - treated
tumor cells on
3 - methylcholanthrene - induced
fibrosarcoma . -
pubmed
Active immunotherapy with tumor cells treated in vitro with
Vibrio cholerae neuraminidase (
VCN ) plus
mitomycin C augments the antitumor effects of local x irradiation in the treatment of firmly established
methylcholanthrene - induced
fibrosarcoma ,
MC-43 , in syngeneic
C3H / HeJ female mice . -
pubmed
This study demonstrates that
fenfluramine - induced
hyperthermia and stimulation in the
rabbit result from an indirect action upon
serotonergic receptors . -
pubmed
Splenectomy at this late stage led to rapid relief of symptoms , progressive increase of
Hb and platelets to normal levels and to a quiescent phase of
CLL for a considerable period . -
pubmed
histolytica , which varied in virulence as determined by the development of
liver abscesses in
hamsters , showed the same antigenic patterns with the
mAb and with polyclonal antibodies . -
pubmed
The study of hormonal balance in the presence of pregnancy and labor in females with a history of
infertility treated with
parlodel failed to reveal any negative effect of elevated
prolactin levels on the fetoplacental system . -
pubmed
In a longitudinal study of a female
patient with
systemic lupus erythematosus , we determined numbers of T - lymphocytes and subpopulations ( OKT4 + - and OKT8 + -lymphocytes ) , B - lymphocytes , production of
anti - double - stranded DNA antibody (
anti - ds - DNA - Ab ) , and we investigated the effects of
corticosteroids and
cyclophosphamide on these parameters and clinical disease activity . -
pubmed
Relationship between oral
glucose tolerance and
insulin sensitivity in healthy
man and
type 1 diabetic patients . -
pubmed
The relationship between
insulin sensitivity and oral
glucose tolerance was studied in 8 conventionally treated
type 1 diabetic patients ( age 34 + /- 4 years , relative body weight ( RBW ) 113 + /- 5 % ) and in 11 healthy
subjects ( age 35 + /- 3 years , RBW 114 + /- 2 % ) . -
pubmed
The response to oral
glucose in the
diabetic patients was measured during maintenance of similar peripheral plasma free
insulin levels as in the normal
subjects during the oral
glucose tolerance test ( OGTT ) . -
pubmed
Thus , peripheral
insulin sensitivity contributes to oral
glucose tolerance both in healthy
man , and even to a greater extent , in
type 1 diabetic patients . -
pubmed
Reduced
monoamine oxidase activity in platelets : a possible genetic marker for vulnerability to
schizophrenia . -
pubmed
Monoamine oxidase activity in blood platelets was measured , with
[ ( 14 ) C ] tryptamine as substrate , in 13 monozygotic twin pairs discordant for
schizophrenia and in 23 normal
volunteers . -
pubmed
The
monoamine oxidase activity of both
schizophrenic and nonschizophrenic co - twins was significantly lower than it was for the normals , and it was highly correlated between twins . -
pubmed
In addition , there was a significant inverse correlation between a measure of the degree of the
schizophrenic disorder and the
monoamine oxidase activity . -
pubmed
These data suggest , but do not prove , that reduced platelet
monoamine oxidase activity may provide a genetic marker for vulnerability to
schizophrenia . -
pubmed
There was no significant association of
ABO , Ss , Rhesus , Kell and Duffy blood groups in
vitiligo . -
pubmed
Activation of
renin in an
anaplastic pulmonary adenocarcinoma . -
pubmed
Biochemical characteristics of a
renin - like enzyme secreted by a
pulmonary adenocarcinoma have been studied . -
pubmed
A large fraction of the
renin in this
tumour is inactive . -
pubmed
In comparison with other prohormones produced in
tumours the findings support strongly the proposition that
renin passes through a proenzyme step in synthesis . -
pubmed
The study in 15
patients with
myocardial infarction of the content in the arterial blood and the blood of the coronary sinus of
lactate ,
glucose ,
nonesterified fatty acids has shown the increase of utilization of these substances in 5 cases , appearance of
lactate production and enhancement of
glucose and
insulin extraction in 4 , decrease of extraction of
glucose ,
lactate ,
insulin in 4
patients . -
pubmed
In the complicated cases of
myocardial infarction it was established that the extraction of
glucose ,
insulin decrease and in a number of cased production of
lactate by the myocardium supervenes . -
pubmed
Since the intracellular activity of
glutamine synthetase is significantly decreased after the administration of
APAP to hepatocytes in culture , it is likely that the arylation of this enzyme may be involved in the ensuing
hepatotoxicity . -
pubmed
Repression of
angiotensin II and potentiation of
bradykinin contribute to the synergistic effects of dual
metalloprotease inhibition in
heart failure . -
pubmed
Neutral endopeptidase inhibition (
NEP - I ) and
angiotensin converting enzyme inhibition (
ACE - I ) act synergistically to produce acute beneficial hemodynamic effects in models of
heart failure . -
pubmed
In this study , the potential roles of
Ang II repression and
bradykinin potentiation were evaluated in conscious
cardiomyopathic hamsters with compensated
heart failure . -
pubmed
Hence , both
Ang II repression and
bradykinin potentiation are factors contributing to the synergistic hemodynamic effects of combined
NEP - I and
ACE - I in
hamsters with
heart failure.(ABSTRACT TRUNCATED AT 250 WORDS ) -
pubmed
Discrepancy between biochemical and virological responses to
interferon - alpha in
chronic hepatitis C. -
pubmed
Fluctuations in
elastase of cervical mucus and clinical efficacy of
cefodizime in
obstetric and gynecologic infections . -
pubmed
Clinical efficacy of
cefodizime (
CDZM ) in obstetric and
gynecologic infections and in their prevention , and fluctuations in cervical mucus
elastase in
gynecologic infections and during pregnancy were studied , and the following results were obtained : 1 . -
pubmed
Patients with concomitant
chorioamnionitis showed a significantly higher rate of
elastase elevation than those without this complication ( 63.2 % vs. 25.9 % , P & lt ; 0.005 ) . -
pubmed
Cervical mucus
elastase in
uterine and pelvic infections showed high values before administration of
CDZM but tended to decline with the progress of cure ( 15/19 cases , 78.9 % ) . -
pubmed
This defect in
insulin response leads to a
diabetic - like state . -
pubmed
A
protease activity which co - purified with affinity - purified
fetal bovine serum acetylcholinesterase (
AChE ) has been shown to release the
amyloid protein precursor (
APP ) of
Alzheimer ' s disease from cell membranes . -
pubmed
The
collagen bundles did not adopt a whorled pattern , and the overlying epidermis showed mild
acanthosis and elongation of the rete ridges . -
pubmed
Our study shows that liposomal antisense ODNs targeting
bcl-2 of
human myeloma cells result in increased stability of ODNs with minimal toxicity . -
pubmed
Inhibition of proliferation and
CD25 down - regulation by
retinoic acid in
human adult T cell leukemia cells . -
pubmed
Cytokines in acute and chronic
inflammation . -
pubmed
Inflammation is mediated by a variety of soluble factors , including a group of secreted polypeptides known as
cytokines . -
pubmed
Inflammatory
cytokines can be divided into two groups : those involved in acute
inflammation and those responsible for
chronic inflammation . -
pubmed
This review describes the role played in acute
inflammation by
IL-1 ,
TNF - alpha ,
IL-6 ,
IL-11 ,
IL-8 and other
chemokines ,
G - CSF , and
GM - CSF . -
pubmed
It also describes the involvement of
cytokines in
chronic inflammation . -
pubmed
Some
cytokines , such as
IL-1 , significantly contribute to both acute and chronic
inflammation . -
pubmed
Amplicons from
peacock enteritis and
equine infertility specimens were not typeable according to present
omp1 allelic criteria for the chlamydial species . -
pubmed
Allele typing of amplicons from
swine with intestinal , urogenital , and
respiratory infections demonstrated several unique
omp1 allelic variants of
Chlamydia trachomatis . -
pubmed
Reversal of
cardiac fibrosis in
deoxycorticosterone acetate - salt
hypertensive rats by inhibition of the
renin -
angiotensin system . -
pubmed
This project has determined the expression and deposition of
collagens and
fibronectin and cardiac function in the
deoxycorticosterone acetate (
DOCA)-salt
hypertensive rat after inhibition of the
renin -
angiotensin system . -
pubmed
Thus , inhibition of the
renin -
angiotensin system reverses
cardiac fibrosis in
DOCA - salt
rats and returns some indices of myocardial function to normal . -
pubmed
RESULTS :
Insulin sensitivity of
women with chronic
hypertension and
GDM was approximately twofold lower than those with
GDM only ( 1.54+/-0.35 versus 4.15+/-0.31 , P & lt ; .001 ) and approximately fivefold lower than controls ( 1.54+/-0.35 versus 7.65+/-0.66 , P & lt ; .001 ) . -
pubmed
Women with chronic
hypertension and concomitant
GDM had higher
insulin levels in response to GTT than controls ( P & lt ; .001 repeated measures analysis of variance ) . -
pubmed
Oncostatin M (
OSM ) , a member of the
IL-6 superfamily of
cytokines , is elevated in
patients with
rheumatoid arthritis and , in synergy with
IL-1 , promotes
cartilage degeneration by
matrix metalloproteinases (
MMPs ) . -
pubmed
Smaller central pools of
cholesterol later in life may contribute to reduced
low - density lipoprotein -
cholesterol ( LDL - C ) concentrations in the plasma and thus reduce the risk of
cardiovascular disease . -
pubmed
Furthermore , a comparative expression analysis is presented with
Unc5h3 , deleted in
colorectal cancer and
Netrin-1 . -
pubmed
EXEGESIS : This case report is a 44 year old black
woman who was first seen with a
rheumatoid arthritis clinical presentation associated with the presence of
rheumatoid factor . -
pubmed
Development of gene therapy using
prostate - specific membrane antigen promoter / enhancer with Cre Recombinase / LoxP system for
prostate cancer cells under
androgen ablation condition . -
pubmed
To enhance the efficacy of suicide gene therapy for
prostate cancer under
androgen deprivation , we designed a promoter system that consists of the
prostate - specific membrane antigen (
PSMA ) promoter / enhancer ( PEPM ) and Cre - loxP DNA recombination system . -
pubmed
Alteration of the expression of
Bcl-2 ,
Bcl - x ,
Bax ,
Fas , and
Fas ligand in the involved skin of
psoriasis vulgaris following topical
anthralin therapy . -
pubmed
In this study , we examined the immunohistochemical expression of
apoptosis - regulated protein in the involved
psoriatic skin following topical
anthralin therapy . -
pubmed
HIV-1 + patients with
Kaposi sarcoma (
KS ) were matched for
CD4 count and
HIV-1 RNA viral load to
HIV-1 +
patients without
Kaposi sarcoma ( and negative for
Kaposisarcoma - associated herpesvirus ) . -
pubmed
Despite the impaired functional capacity of dendritic cells ( DCs ) derived from
patients with
KS , DCs retain the ability to prime the adaptive arm of the immune system through the common
HSP receptor , leading to phenotypic activation and stimulation of tetramer - positive CD8 + cytotoxic T cells . -
pubmed
[ Acquired
hemolytic anemia ; follow - up over a long period of a
patient treated with
ACTH and
cortisone ] . -
pubmed
Serum
leptin concentration and advanced
gastrointestinal cancers : a case controlled study . -
pubmed
We aimed to evaluate the serum
leptin concentration and the other factors which may be associated with
weight loss in
patients with advanced
gastrointestinal cancer . -
pubmed
The difference in serum
leptin concentration between
cancer and control group , the factor associated with its serum level and the relationship between serum
leptin concentration and
weight loss was evaluated . -
pubmed
RESULTS : Serum
leptin concentration of
cancer group was significantly lower than controls ( p = 0.002 ) . -
pubmed
Female
subjects had significantly higher serum
leptin concentration than
male subjects in control group ( p = 0.01 ) , while not in
cancer group ( p & gt ; 0.05 ) . -
pubmed
Serum
leptin concentration was significantly related with gender in controls ( p = 0.023 , beta = 0.479 ) , while no gender difference was observed in
cancer group ( p & gt ; 0.05 ) . -
pubmed
No relationship was found between serum
leptin concentration and
weight loss percentage in
cancer group in linear regression analysis ( p & gt ; 0.05 ) . -
pubmed
No significant difference was observed in serum
leptin concentrations between colon and
gastric cancer sub - groups ( p & gt ; 0.05 ) . -
pubmed
CONCLUSION : Independently from the site of gastrointestinal tract , serum
leptin concentration in advanced
gastrointestinal cancer is lower than controls and it is not a determinant factor in
weight loss . -
pubmed
In contrast to healthy subjects , gender does not effect the serum
leptin concentration in
patients with advanced
gastrointestinal cancer . -
pubmed
Growth factor therapy for
vocal fold scarring in a
canine model . -
pubmed
Hepatocyte growth factor (
HGF ) has strong antifibrotic activity and has proved to have therapeutic potential in restoration of
scar tissues such as
liver cirrhosis and
lung fibrosis . -
pubmed
Canine vocal folds were stripped unilaterally and treated with intracordal injection of saline solution ( sham group ) ,
HGF (
HGF group ) , or
HGF with cultured autologous normal vocal fold fibroblasts ( Fb /
HGF group ) 1 month after
injury . -
pubmed
However , the
HGF group presented much better results than both the sham and Fb /
HGF groups in terms of mucosal wave amplitude and incidence of vocal fold bowing ,
glottal incompetence , and phase asymmetry . -
pubmed
From these data it is concluded that
HGF has considerable potential in the treatment of
vocal fold scarring . -
pubmed
Capillary tube collapse is accompanied by
collagen gel contraction , which is strongly related to the
wound contraction that occurs during regression of granulation tissue in vivo . -
pubmed
Comparison of
erythema and induration as results of
tuberculin tests . -
pubmed
DESIGN : The distributions of diameters of
erythema and induration were compared among three groups : 951
TB patients , 6139 first - grade and 6185 seventh - grade children , and 97 volunteer employees classified as atopic or non - atopic on the basis of skin tests and serum
immunoglobulin E (
IgE ) concentrations . -
pubmed
CONCLUSION : Both
erythema and induration appear to be adequate indices of
tuberculin sensitivity . -
pubmed
The candidate
tumor suppressor gene
ZAC is involved in keratinocyte differentiation and its expression is lost in
basal cell carcinomas . -
pubmed
ZAC expression is lost or down - regulated in some breast , ovary , and
pituitary tumors and in an in vitro model of ovary epithelial cell transformation . -
pubmed
In the present study , we examined
ZAC expression in
normal skin and found a high expression level in basal keratinocytes and a lower , more heterogeneous , expression in the first suprabasal differentiating layers of epidermis . -
pubmed
Interestingly , we found a dramatic loss of
ZAC expression in
basal cell carcinoma , a
neoplasm characterized by a relatively undifferentiated morphology . -
pubmed
In contrast ,
ZAC expression was maintained in
squamous cell carcinomas that retain the squamous differentiated phenotype . -
pubmed
In the PNS , we recently showed that Schwann cell - derived
EPO acts as an endogenous neuroprotectant and that it is most effective in preventing distal axonal degeneration seen in models of
peripheral neuropathy . -
pubmed
Similarly , we showed that
immunophilin ligands are also neuroprotective in the PNS and prevent
axonal degeneration seen in models of
peripheral neuropathies . -
pubmed
Both
EPO and non - immunosuppressive immunophilin ligands are in early clinical development for the treatment of acquired
peripheral neuropathies . -
pubmed
Is elevated plasma
B - natriuretic peptide in
amyloidosis simply a function of the presence of
heart failure ? -
pubmed
This study sought to determine plasma levels of
B - natriuretic peptide (
BNP ) in
patients with light - chain - associated
amyloidosis and correlate them with the presence or absence of
heart failure (
HF ) and the presence or absence of echocardiographic abnormalities . -
pubmed
Patients with normal echocardiographic results had significantly lower
BNP levels than those with echocardiographic features of
cardiac amyloidosis , whereas
BNP levels in the group with
HF did not differ from those in
patients with asymptomatic
cardiac amyloidosis . -
pubmed
This observation supports previous observations , suggesting that the elevation of
BNP in
cardiac amyloidosis may be due not only to elevated ventricular filling pressure but also to direct myocyte damage due to extracellular deposits of
amyloid . -
pubmed
HSP70 vaccine in combination with gene therapy with plasmid DNA encoding
sPD-1 overcomes immune resistance and suppresses the progression of
pulmonary metastatic melanoma . -
pubmed
However , strong T - cell response does not always coincide with
tumor rejection , for which upregulated expression of
immunoinhibitory molecules may be responsible . -
pubmed
In this study , the treatment with
heat shock protein 70 (
HSP70 ) vaccine induced an infiltration of T cells into the
tumor site as well as the expression of
IFN - gamma and
IL-2 , and delayed lung metastases of
tumor , but the
tumor progression nonetheless occur finally . -
pubmed
We demonstrated that
B7 - H1 expressed by residual
tumor cells was responsible for the resistance of
tumor to the therapy with
HSP70 vaccine . -
pubmed
To complement these findings , we investigated the gene expression of tumor - infiltrating lymphocytes ( TILs ) by Real - time PCR analysis , which revealed that the expression of
TH1 cytokines IFN - gamma and
IL-2 by TIL in the
mice treated with
HSP70 vaccine in combination with
sPD-1 was increased and the expression of
negative regulatory molecules IL-10 ,
TGF - beta and
foxp3 was decreased , demonstrating that multifunctional properties afforded by the combination therapy can effectively overcome
tumor resistance and promote effective antitumor immunity . -
pubmed
These findings suggest that the treatment with
HSP70 vaccine followed by blockade of
tumor - B7 - H1 with
sPD-1 may provide a promising approach for
tumor immunotherapy . -
pubmed
Pseudohypoparathyroidism Type 1 and
Pseudo - pseudohypoparathyroidism occur as a consequence of reduced erythrocyte membrane coupled with
Gs alpha activity . -
pubmed
Altered
neuregulin 1 -
erbB4 signaling contributes to
NMDA receptor hypofunction in
schizophrenia . -
pubmed
Recent molecular genetics studies implicate
neuregulin 1 (
NRG1 ) and its receptor
erbB in the pathophysiology of
schizophrenia . -
pubmed
Here , using a new postmortem tissue - stimulation approach , we show a marked increase in
NRG1 - induced activation of
erbB4 in the prefrontal cortex in
schizophrenia . -
pubmed
Levels of
NRG1 and
erbB4 , however , did not differ between
schizophrenia and control groups . -
pubmed
Schizophrenia subjects showed substantial increases in
erbB4 -
PSD-95 interactions . -
pubmed
NRG1 - induced suppression of
NMDA receptor activation was more pronounced in
schizophrenia subjects than in controls , consistent with enhanced
NRG1 -
erbB4 signaling seen in this illness . -
pubmed
Therefore , these findings suggest that enhanced
NRG1 signaling may contribute to
NMDA hypofunction in
schizophrenia . -
pubmed
Plasma
leptin levels in
patients with
floppy eyelid syndrome . -
pubmed
PURPOSE : To determine the range of plasma
leptin levels in
patients with
floppy eyelid syndrome (
FES ) . -
pubmed
Charts were reviewed for
patient age , sex , plasma
leptin level , body mass index ( BMI ) , presence or absence of
obstructive sleep apnea (
OSA ) and
diabetes mellitus , and any treatments for
OSA . -
pubmed
CONCLUSIONS :
Patients with
FES demonstrate elevated plasma
leptin levels , which correlate with BMI . -
pubmed
The latest anti - poxvirus drugs are
kinase inhibitors , which were originally developed to treat
cancer progression but in addition block egress of poxviruses from infected cells . -
pubmed
Erythropoietin promotes survival of retinal ganglion cells in DBA/2J
glaucoma mice . -
pubmed
METHODS : The neuroprotective effects of
EPO were studied in the DBA/2J
mouse model of
glaucoma . -
pubmed
CONCLUSIONS :
EPO promoted RGC survival in DBA/2J
glaucomatous mice without affecting IOP . -
pubmed
These results suggest that
EPO may be a potential therapeutic neuroprotectant in
glaucoma . -
pubmed
In spite of the difference between the compounds in both half - life and engagement of
serotonin receptors , they appear to have very similar effectiveness in reducing
hot flushes . -
pubmed
Increased
angiotensinogen production in epicardial adipose tissue during cardiac surgery : possible role in a postoperative
insulin resistance . -
pubmed
Recently , local
renin - angiotensin system of adipose tissue has been suggested as a possible contributor to the development of
insulin resistance in
patients with
obesity . -
pubmed
Cardiac surgery significantly increased both
insulin and blood
glucose levels suggesting the development of
insulin resistance , while serum
adiponectin levels did not change . -
pubmed
Our study suggests that increased
angiotensinogen production in epicardial adipose tissue may contribute to the development of postoperative
insulin resistance . -
pubmed
In cardiology practice , the standard method of evaluating
patients with suspected
ischemic myocardial injury is an assay that measures the release of
troponin into the bloodstream . -
pubmed
In hematologic oncology practice ,
troponin has been investigated extensively as a measure of
myocardial injury after therapy with radiation and
anthracyclines and after myeloablative therapies with stem cell replacement . -
pubmed
The use of
troponin to assess the value of cardioprotective agents ( used for prevention of chemotherapy - induced
myocardial injury ) also is reviewed . -
pubmed
Because a number of nonmalignant
hematologic disorders such as
hypereosinophilic syndrome ,
thrombotic thrombocytopenic purpura , and
immunoglobulin light - chain amyloidosis can affect the heart , the use of the
troponin in assessing these patients ' prognoses is also covered . -
pubmed
Knockdown of cytosolic
5 '- nucleotidase II (
cN - II ) reveals that its activity is essential for survival in
astrocytoma cells . -
pubmed
Fluctuations of
cN - II activity have been associated with the pathogenesis of
neurological disorders . -
pubmed
To address this issue , we used a vector based short hairpin RNA ( shRNA ) strategy to knockdown
cN - II activity in
human astrocytoma cells . -
pubmed
Since
cN - II is highly expressed in
tumour cells , our finding offers a new possible therapeutical approach especially against primary
brain tumours such as
glioblastoma , and to ameliorate chemotherapy against
leukemia . -
pubmed
Effect of
metformin on serum
visfatin levels in
patients with
polycystic ovary syndrome . -
pubmed
OBJECTIVE : To evaluate serum
visfatin levels and to determine the effects of
metformin treatment on
visfatin levels in
patients with
polycystic ovary syndrome (
PCOS ) . -
pubmed
INTERVENTION(S ):
Metformin was given to
patients with
PCOS , and serum
visfatin levels were measured before and after treatment . -
pubmed
MAIN OUTCOME MEASURE(S ):
Glucose ,
triglycerides ,
high - density lipoprotein cholesterol ,
low - density lipoprotein cholesterol ,
DHEAS , total T ,
insulin , homeostatic model assessment for
insulin resistance (
HOMA - IR ) , and
visfatin levels were measured . -
pubmed
RESULT(S ): Serum
visfatin levels were significantly higher in
women with
PCOS than in controls . -
pubmed
After therapy , statistically significant decreases in HOMA - IR , fasting
insulin , free T , and
DHEAS concentrations were observed for the
PCOS group . -
pubmed
CONCLUSION(S ): Circulating
visfatin levels were higher in
patients with
PCOS than healthy controls , and
metformin treatment significantly reduced circulating
visfatin concentrations after 3 months of therapy . -
pubmed
Numerous studies have shown that the
microtubule - associated protein tau (
Mapt ) gene plays an important role in
tauopathies . -
pubmed
Expression correlation and genetic network analysis demonstrated that
Mapt co - varies with many
tauopathies - related genes , including
Gsk3b ,
Falz ,
Apbb2 ,
Slc1a3 ,
Ntrk2 ,
Pik3ca , and
Ikbkap . -
pubmed
The prevalence in
human cancers of mutations in
p53 exemplifies its crucial role as a
tumor suppressor transcription factor . -
pubmed
It has been proposed that the mildly enhanced
VWF proteolysis associated with C1584 ( and also with blood group O ) may compromise clot formation , offering a further rationale for the enrichment of the variant in
type 1 VWD . -
pubmed
It reflects the interaction of C1584 with other variables , one of which is clearly blood group O. Genome - wide association studies aimed at identifying loci involved in the control of the
VWF level may provide further insights into C1584 penetrance and , more generally , into mechanisms underlying
type 1 VWD and also
cardiovascular disease . -
pubmed
GENETIC COUNSELING : The
hereditary ataxias can be inherited in an autosomal dominant , autosomal recessive , or X - linked manner . -
pubmed
Inactivation of
presenilins causes pre - synaptic impairment prior to
post - synaptic dysfunction . -
pubmed
Presenilins 1 and 2 are the major causative genes of early - onset
familial AD . -
pubmed
We show that ectopic expression of
snail in developing olfactory neurons leads to severe defects in neurons of the antennal large basiconics , supporting the model that the dominant olfactory phenotype in
Scutoid is caused by misexpression of
snail . -
pubmed
The
animals were analyzed for clinical manifestation of
arthritis , hematology and clinical chemistry , immunological responses against
CII and histopathological features of the
arthritis . -
pubmed
BACKGROUND : Immunological and genetic findings implicate Th17 effector
cytokines in the pathogenesis of
inflammatory bowel disease (
IBD ) . -
pubmed
The present study assessed the mRNA expression levels of Th17 effector
cytokines (
IL17A ,
IL17F ,
IL21 ,
IL22 and
IL26 ) and genes involved in differentiation (
IL6 ,
IL1B ,
TGFB1 ,
IL23A and
STAT3 ) and recruitment of Th17 cells (
CCR6 and
CCL20 ) by quantitative real - time PCR analysis of colonic and ileal biopsies from 22 healthy control subjects , 26
patients with
Crohn ' s disease (
CD ) and 12
patients with
ulcerative colitis (
UC ) . -
pubmed
Inflammation was quantified by measuring expression of the
inflammatory mediators IL8 and
TNF . -
pubmed
G6PD - MutDB : a mutation and phenotype database of
glucose-6 - phosphate ( G6PD ) deficiency . -
pubmed
Glucose-6 - phosphate dehydrogenase ( G6PD ) deficiency is the most common
hereditary enzymatic disorder of red blood cells in
humans due to mutations in the
G6PD gene . -
pubmed
G6PD - MutDB is a disease - specific resource of
G6PD deficiency , collecting and integrating
G6PD mutations with biochemical and clinical phenotypes . -
pubmed
G6PD - MutDB implements an approach , CNSHA predictor , to help identify a potential
chronic non - spherocytic hemolytic anemia (
CNSHA ) phenotype of an unknown mutation . -
pubmed
Apoptosis induced by a new
flavonoid in
human hepatoma
HepG2 cells involves reactive
oxygen species - mediated
mitochondrial dysfunction and
MAPK activation . -
pubmed
BACKGROUND AND AIMS :
Allergic rhinitis (
AR ) and
asthma share common mediators ,
cytokines , and
chemokines from mast cells and basophils that are central to the complex cascade of events involved in the inflammatory response . -
pubmed
MATERIAL AND METHODS : A comprehensive literature search was conducted for the following terms , alone or in combination :
allergic rhinitis ,
asthma , antihistamines ,
histamine , and
histamine receptors , and for the second - generation antihistamines
azelastine ,
cetirizine ,
desloratadine ,
ebastine ,
fexofenadine ,
levocetirizine ,
loratadine ,
mizolastine , and
rupatadine . -
pubmed
alpha - Synuclein phosphorylation as a therapeutic target in
Parkinson ' s disease . -
pubmed
A prototypical protein that is hyperphosphorylated in the brain is
alpha - synuclein (
alpha - syn ) - found in Lewy bodies and Lewy neurites - the pathological hallmarks of
Parkinson ' s disease (
PD ) and other
alpha - synucleinopathies . -
pubmed
The genetic linkage of
alpha - syn to
PD as well as its pathological association in both genetic and sporadic cases have made it the primary protein of interest . -
pubmed
We postulated that allergen - induced increase in FeNO could be related to heightened mucosal eosinophils and
AHR to
bradykinin in
atopic asthma . -
pubmed
In 10 atopic mild
asthmatics , we found that the numbers of EG-2 + and
CD4 + cells in bronchial submucosa were significantly increased after allergen compared to the respective counts after diluent ( p & amp;#x003C ; 0.01 ) . -
pubmed
Gamma - glutamyl transferase : risk and prognosis of
cancer . -
pubmed
FK506 - binding protein 51 (
FKBP5 ) gene polymorphism is not associated with glucocorticoid therapy outcome in
patients with
idiopathic thrombocytopenic purpura . -
pubmed
The
FKBP5 gene single nucleotide polymorphisms ( SNP ) , rs1360780 , has been found to modulate GC sensitivity in stress - related
psychiatric disorders . -
pubmed
The polymorphism of
FKBP5 , rs1360780 , was genotyped in 55 GC - resistant
ITP patients , 157 GC - sensitive
ITP patients and 110 unrelated healthy individuals using real - time PCR and cycling probe technology with DNA extracted from peripheral blood . -
pubmed
No significant differences in
FKBP5 rs1360780 genotypes ( P=0.51 ) and alleles ( P=0.89 ) were observed between the GC - resistant
ITP patients and the healthy controls . -
pubmed
The present study demonstrates that the
FKBP5 polymorphism may not affect the response of
ITP patients to GC treatment . -
pubmed
Deletion of
Flt1 from specialized glomerular pericytes , known as podocytes , causes reorganization of their cytoskeleton with massive
proteinuria and
kidney failure , characteristic features of
nephrotic syndrome in
humans . -
pubmed
Antiplatelet therapy with
aspirin and a platelet
P2Y12 receptor antagonist reduces
thrombotic and
ischemic events after percutaneous coronary intervention and
acute coronary syndrome . -
pubmed
Radiosensitization of
prostate cancer cells by the dual
PI3K /
mTOR inhibitor
BEZ235 under normoxic and hypoxic conditions . -
pubmed
Radioresistance may be due to tumor -
hypoxia but also due to the
PTEN mutation / deletion present in 70 %
prostate cancers . -
pubmed
We investigated whether the novel
PI3K /
mTOR inhibitor
BEZ235 might sensitize
prostate cancer cells to radiation and reduce
hypoxia - induced radioresistance . -
pubmed
MATERIALS AND METHODS : The potential radiosensitizing properties of
BEZ235 were investigated in vitro and in vivo using two
prostate cancer cell lines ,
PC3 (
PTEN(-/- ) ) and
DU145 (
PTEN(+/+ ) ) , under normoxic ( 21 %
O ( 2 ) ) and hypoxic ( 0.5 %
O ( 2 ) ) conditions . -
pubmed
RESULTS :
BEZ235 rapidly inhibited
PI3 K and
mTOR signaling in a dose dependent manner and limited
tumor cell proliferation and clonogenic survival in both cell lines independently of
PTEN status . -
pubmed
Moreover ,
BEZ235 inhibited
PI3K /
mTOR activation and radiosensitized both cell lines under normoxia and
hypoxia . -
pubmed
Serum carbohydrate antigen 125 is not an independent prognostic factor in
patients with
chronic lymphocytic leukemia . -
pubmed
METHODS : We measured serum
CA-125 concentration in 112
patients with
chronic lymphocytic leukemia (
CLL ) and evaluated their association with Binet stage ,
serum lactate dehydrogenase (
LDH ) ,
beta2 - microglobulin (
beta2 - MG ) ,
CD38 ,
70 - kDa zeta - associated protein (
ZAP-70 ) , immunoglobulin heavy - chain variable region (
IGHV ) mutated status and
cytogenetic abnormalities . -
pubmed
CD38 - positive ( p=0.020 ) and unmutated
IGHV status ( p=0.034 ) were independent risk factors of worse OS . -
pubmed
However ,
CA-125 is not an independent prognostic factor in
patients with
CLL . -
pubmed
The
IGF receptor (
IGF - R ) pathway represents a potential actionable target in
SCLC patients . -
pubmed
Indeed , the
IGF - R pathway is involved in
cancer development and progression and regulates different vital processes including fetal development , growth and metabolism . -
pubmed
AREAS COVERED : This review provides an overview of
insulin inhibitors and the strategies undertaken in recent years with
SCLC . -
pubmed
Furthermore ,
insulin inhibitors may have some utility in the treatment of
SCLC and further studies are required to identify subsets of
patients most likely to benefit from their use . -
pubmed
The authors also believe that it is important to determine the exact role of the
IGF pathway in the pathogenesis and propagation of
SCLC . -
pubmed
Therefore B2 may be a promising candidate for further clinical studies and the appropriate use of
GAD agonist may be a promising approach for
sleep disorders . -
pubmed
Aim of the study was to investigate the role of
peanut- and
hazelnut - component - specific
IgE in the diagnostics of
peanut and hazelnut allergy and to identify cutoff levels to make some challenges superfluous . -
pubmed
A 90 % probability for a positive
peanut or
hazelnut challenge was estimated for Ara h 2 - specific
IgE at 14.4 kU / l and for Cor a 14 - specific
IgE at 47.8 kU / l. A 95 % probability could only be estimated for Ara h 2 at 42.2 kU / l. CONCLUSIONS : Ara h 2- and Cor a 14 - specific
IgE are useful to estimate the probability for a positive challenge outcome in the diagnostic work - up of
peanut or
hazelnut allergy making some food challenges superfluous . -
pubmed
Multicentre randomised phase II trial of
gemcitabine+
platinum , with or without trastuzumab , in advanced or metastatic
urothelial carcinoma overexpressing
Her2 . -
pubmed
AIM : To investigate the efficacy and safety of
gemcitabine and
platinum salt , with or without trastuzumab , in
patients with locally advanced or metastatic
urothelial carcinoma overexpressing
Her2 . -
pubmed
METHODS : The main eligibility criterion was
Her2 overexpression on immunohistochemistry ( IHC 2 + or 3 + ) of primary
tumour tissue confirmed by fluorescence in situ hybridisation ( FISH ) . -
pubmed
Multiple compound - related adverse properties contribute to
liver injury caused by
endothelin receptor antagonists . -
pubmed
Drug - induced
liver injury has been observed in
patients treated with the
endothelin receptor antagonists
sitaxentan and
bosentan , but not following treatment with
ambrisentan . -
pubmed
Mutations in
NADH dehydrogenase (
ND ) subunits of complex I lead to
mitochondrial encephalomyopathies associated with various phenotypes . -
pubmed
Reduction of
CD8(+ ) T lymphocytes in
multiple sclerosis patients treated with
dimethyl fumarate . -
pubmed
Patients with
nephrotic syndrome typically present with
peripheral oedema , massive
urinary protein loss and associated low
serum albumin levels . -
pubmed
Taken together , our study indicates that miR-204 may contribute to the development of
preeclampsia by inhibiting trophoblastic invasion , and that
MMP9 is involved in miR-204 - mediated trophoblast cell invasion . -
pubmed
Predictors of early discontinuation of basal
insulin therapy in
type 2 diabetes in primary care . -
pubmed
AIMS : To identify
patient - related characteristics and other impact factors predicting early discontinuation of basal
insulin therapy in
type 2 diabetes in primary care . -
pubmed
In multivariable logistic regression , predictors of early basal
insulin discontinuation were & gt;=1 documented
hypoglycemia before ID ( adjusted Odds ratio ; 95 % CI : 2.20 ; 1.27 - 3.82 ) , diagnosed
depression ( 1.31 ; 1.01 - 1.70 ) and referrals to specialists within 90 days after ID ( 2.06 ; 1.61 - 2.63 ) . -
pubmed
CONCLUSIONS : Less than 10 % of
type 2 diabetes patients switched back to oral antidiabetic drugs within 90 days after start of basal
insulin therapy . -
pubmed
In particular , patients with baseline
depression and frequent or severe
hypoglycemia have a higher likelihood for early discontinuation of basal
insulin , whereas use of
insulin glargine and diabetologist care are related to an increased chance of continuous
insulin treatment . -
pubmed
FOXP3 + T - regulatory ( Treg ) cells have important roles in immune homeostasis , and alterations in their number and function can predispose to diseases ranging from autoimmunity to allograft rejection and
tumor growth . -
pubmed
Cystatin C- and
creatinine - based estimation of glomerular filtration rate ( eGFRcys and eGRFcreat , respectively ) and urinary
albumin /
creatinine ratio ( ACR ) were assessed to investigate their relationship with the risk of
atrial fibrillation . -
pubmed
Leuprolide acetate , a synthetic nonapeptide analogue of
gonadotropin - releasing hormone (
GnRH or
LHRH ) , is the active pharmaceutical ingredient used to treat a wide range of sex hormone - related disorders , including advanced
prostatic cancer ,
endometriosis , and
precocious puberty . -
pubmed
This study aimed to explore the possibility of an association between
lipoxin A4 and
interleukin-12 in
chronic periodontitis . -
pubmed
CONCLUSIONS : The mean
interleukin-12 concentration was significantly higher in gingival crevicular fluid from
patients with
periodontitis than in that from with healthy
patients , and the mean
lipoxin A4 concentration was lower in
patients with
periodontitis than in healthy
patients . -
pubmed
Tumors from patients with progressive disease showed a higher variance of the intrapatient mutational spectrum and a higher frequency of
APOBEC - related mutations . -
pubmed
However ,
neutrophil - predominant pleural TB was associated with significantly higher inflammatory serum markers , such as white blood cell count ( P = 0.001 ) and
C - reactive protein ( P = 0.001 ) . -
pubmed
The canonical
NF - kappaB pathway has been implicated in the initiation of GC reaction , and defects in this pathway have been linked to
immune deficiencies . -
pubmed
Lastly , we show that ectopic expression of
Bcl-2 can partially rescue the
GC phenotype in
MALT1 - deficient
animals by prolonging the lifespan of
BCR - activated B cells , but plasma cell differentiation and Ab production remain defective . -
pubmed
Significance of dynamic changes in gastric smooth muscle cell apoptosis ,
PI3K -
AKT -
mTOR and
AMPK -
mTOR signaling in a
rat model of
diabetic gastroparesis . -
pubmed
The aim of the present study was to investigate the significance of cell apoptosis , the
phosphoinositide-3 - kinase (
PI3K)-
protein kinase B (
AKT)-
mammalian target of rapamycin (
mTOR ) pathway , and the
5 ' adenosine monophosphate - activated protein kinase (
AMPK)-
mTOR pathways in the process of
diabetic gastroparesis . -
pubmed
The apoptosis of gastric smooth muscle cells gradually increased in all
diabetic groups , and significant changes were observed in key proteins involved in
PI3K -
AKT -
mTOR and
AMPK -
mTOR signaling . -
pubmed
The results indicated that apoptosis was important in the occurrence of
diabetic gastroparesis , and the
PI3K -
AKT -
mTOR and
AMPK -
mTOR pathways were activated during the apoptotic processes , but were incapable of regulating apoptosis . -
pubmed
METHODS : 448
RA and 648 healthy controls were genotyped for single - nucleotide polymorphisms ( SNPs ) in genes
ZKSCAN5 ( rs11761528 ) ,
SULT2A1 ( rs2637125 ) ,
HHEX ( rs2497306 ) , and
ARPC1A ( rs740160 ) . -
pubmed
The cumulative number of alleles associated with lower
DHEAS within genes
ZKSCAN5 ,
SULT2A1 ,
HHEX , and
ARPC1A present in each individual negatively correlated with
DHEAS levels in
RA patients , but not in controls . -
pubmed
Linear regression analysis showed significant effect of polymorphisms in genes
ZKSCAN5 and
ARPC1A on serum
DHEAS levels in female
RA patients but not in the control group . -
pubmed
Carbonic anhydrase I ,
betaine - homocysteine S - methyltransferase 1 ,
fumarate hydratase ,
isovaleryl - CoA dehydrogenase ,
short - chain specific acyl - CoA dehydrogenase and
arginase-1 were all down - regulated in the
tumors with
portal vein thrombosis . -
pubmed
CONCLUSION : Metabolic enzymes and
cytosol carbonic anhydrases were downregulated in
hepatocellular carcinoma with
portal vein thrombus . -
pubmed
The deficiency of metabolic enzymes and
cytosol carbonic anhydrases may alter cellular metabolisms and acid - base balance in
hepatocellular carcinoma , which may facilitate to invade portal vein . -
pubmed
Rindopepimut with
temozolomide for
patients with newly diagnosed ,
EGFRvIII - expressing
glioblastoma ( ACT IV ): a randomised , double - blind , international phase 3 trial . -
pubmed
In the ACT IV study , we aimed to assess whether or not the addition of rindopepimut to standard chemotherapy is able to improve survival in
patients with
EGFRvIII - positive
glioblastoma . -
pubmed
Eligible
patients had newly diagnosed
glioblastoma confirmed to express
EGFRvIII by central analysis , and had undergone maximal surgical resection and completion of standard chemoradiation without progression . -
pubmed
Patients were stratified by European Organisation for Research and Treatment of
Cancer recursive partitioning analysis class ,
MGMT promoter methylation , and geographical region , and randomly assigned ( 1:1 ) with a prespecified randomisation sequence ( block size of four ) to receive rindopepimut ( 500 mug admixed with 150 mug
GM - CSF ) or control ( 100 mug keyhole limpet
haemocyanin ) via monthly intradermal injection until progression or intolerance , concurrent with standard oral
temozolomide ( 150 - 200 mg / m2 for 5 of 28 days ) for 6 - 12 cycles or longer . -
pubmed
METHODS : A total of 157
HIV - infected patients were screened through standard serological tests , including Wright 's test , Coombs ' Wright test , and
2 - mercaptoethanol Brucella agglutination test (
2ME test ) , blood cultures in Castaneda media , and
CD4 counting . -
pubmed
Moreover , patients with positive serology and a mean
CD4 count of 355.8 + - 203.11 cells / muL had no clinical manifestations of
brucellosis , and , and the other patients had a mean
CD4 count of 335.55 + - 261.71 cells / muL. -
pubmed
Recently , a number of reports have described dominant
C3 deposits in renal biopsies of
patients with
infection - related glomerulonephritis (
GN ) . -
pubmed
While acute post - infectious
GN and membranoproliferative
GN are commonly characterized by immune deposits containing
C3 and/or
C4 , the absence of
immunoglobulin (
Ig ) and/or immune complexes at light or electron microscopy is a rather unusual observation . -
pubmed
A more thorough understanding of the pathways that lead to complement assembly and deposition within the kidney is needed to support a new classification of
complement - related lesions , including entities such as
dense deposit disease , ( atypical )
hemolytic - uremic syndrome , dominant C1q ,
CFHR5 , C4d , and
C3 glomerulopathies . -
pubmed
We will briefly review recent work in this area , focusing on
GN with selective
complement C3 deposits . -
pubmed
Studies in recent years have shown that electrical stimulation of the vagal efferent fibers can artificially modulate
cytokine levels and reduce systematic
inflammation . -
pubmed
B - type natriuretic peptide is a useful biomarker for the estimation of
volume overload in
children with
hypertension on peritoneal dialysis . -
pubmed
AIM : The aim of the present study was to evaluate the usefulness of serum
B - type natriuretic peptide (
BNP ) as a biomarker of fluid retention in
hypertensive children on peritoneal dialysis ( PD ) . -
pubmed
CONCLUSIONS : Serum
B - type natriuretic peptide should be measured in
hypertensive patients on PD to evaluate the volume status . -
pubmed
KIF16B is a candidate gene for a novel
autosomal - recessive intellectual disability syndrome . -
pubmed
ALRN-6924 induced a complete remission in a
patient with
TP53 - wild - type
angioimmunoblastic T - cell lymphoma , demonstrating the potential for rapid translation of discoveries from subtype - specific preclinical models . -
pubmed
TGFA and miR-130b were also inversely expressed in
osteosarcoma tissues . -
pubmed
In addition , expression of
TGFA was able to alter miR-130 - regulated
osteosarcoma cell proliferation , migration and invasion . -
pubmed
P - glycoprotein targeted photodynamic therapy of chemoresistant
tumors using recombinant Fab fragment conjugates . -
pubmed
P - glycoprotein (
Pgp ) has been considered as a major cause of
cancer multidrug resistance ; however , clinical solutions to overcome this drug resistance do not exist despite the tremendous endeavors . -
pubmed
In a
mouse xenograft model of chemoresistant
tumors , Fab conjugates showed
Pgp specific delivery to chemoresistant
tumors . -
pubmed
Transforming growth factor - beta1 (
TGF - beta1 ) is one of very few
cytokines produced in a latent form , requiring activation to exert any of its vastly diverse effects on development , immunity , and
cancer . -
pubmed
Copanlisib : An Intravenous
Phosphatidylinositol 3 - Kinase (
PI3 K ) Inhibitor for the Treatment of
Relapsed Follicular Lymphoma . -
pubmed
Data Synthesis :
Copanlisib is the first intravenous
phosphatidylinositol 3 - kinase (
PI3 K ) inhibitor approved for the treatment of relapsed
FL in
patients who have received at least 2 prior systemic therapies . -
pubmed
CASE PRESENTATION : The first
patient was a 48 - year - old - Asian
woman who presented with serum
growth hormone 6.99 ng / ml and
insulin - like growth factor 1 of 476 ng / ml , but no characteristic features of
acromegaly . -
pubmed
The second
patient was a 40 - year - old - Asian
woman who presented with serum
growth hormone 31.14 ng / ml and
insulin - like growth factor 1 of 709.6 ng / ml , but no characteristic features of
acromegaly . -
pubmed
The third
patient was a 64 - year - old - Asian
woman who presented with serum
growth hormone 6.0 ng / ml and
insulin - like growth factor 1 of 341 ng / ml , but no characteristic features of
acromegaly . -
pubmed
OBJECTIVES :
Patients with
Kawasaki disease can develop life - altering
coronary arterial abnormalities , particularly in those resistant to intravenous immunoglobulin (
IVIg ) therapy . -
pubmed
We tested the
tumor necrosis factor alpha receptor antagonist etanercept for reducing both
IVIg resistance and
coronary artery ( CA ) disease progression . -
pubmed
Mutations of
SATB2 ( OMIM#608148 ) gene at 2q33.1 have been associated with the
autosomal dominant SATB2 - associated syndrome (
SAS ) , which is still short of comprehensive diagnosis technologies for small deletions and low - level mosaicism . -
pubmed
In this Chinese Han family , single nucleotide polymorphism array identified a 4.9 - kb deletion in the
SATB2 gene in two consecutive siblings exhibiting obvious
developmental delay and
dental abnormalities but failed to find so in their parents . -
pubmed
Angiotensin II (
ATII ) is a
noncatecholamine vasopressor recently approved for the management of distributive
shock , but limited data support its clinical utility . -
pubmed
After logistic regression , it was observed that inadequacies of
calcium ( OR : 4.11 ; 95 % CI : 2.33 - 6.66 ) ,
phosphorus ( OR : 3.03 ; 95 % CI : 1.98 - 5.79 ) ,
vitamin D ( OR : 5.01 ; 95 % CI : 2.92 - 6.71 ) and
PTH ( OR : 5.45 ; 95 % CI : 4.49 - 6.74 ) were significantly higher in the
MUHO group compared to the MHO Group . -
pubmed
Hyperglycemia is a known complication of therapies used in the treatment of childhood
cancer , particularly glucocorticoids and
asparaginase . -
pubmed
Like other types of
DEB , EBP results from heterozygous or bi - allelic mutations in the gene
COL7A1 encoding
collagen VII which is the main component of the anchoring fibrils . -
pubmed
CONCLUSION : In conclusion , this review summarizes recent progress in developing
protease inhibitors for
SARS - CoV-2 . -
pubmed
Long - term tracking of
tumor cell
nestin expression in vivo revealed a stronger TM network integration and higher radioresistance of the
nestin - high subpopulation . -
pubmed
Glioblastoma cells that were both
nestin - high and network - integrated were particularly able to adapt to radiotherapy with increased TM formation . -
pubmed
Glucosyltransferase activity in kidney fractions of normal and
streptozotocin -
diabetic rats . -
pubmed
Glucosyltransferase (
UDPglucose : galactosylhydroxylysine - basement membrane glucosyltransferase ) , an enzyme specifically involved in
collagen synthesis , was measured in various kidney fractions of normal ,
diabetic and underfed
rats , using as basis the incorporation of radioactivity into protein during incubation with
UDP [ U-14C ] glucose and alkali - soluble fetal calf - skin
collagen . -
pubmed
Seven to 21 d after removing the inhibitor ( & gt ; or = 14 d after
infection ) , the cells were trypsinized , passed to monolayers of
human embryonic lung fibroblasts , and observed for
VZV reactivation as indicated by typical cytopathic effects and the appearance of
VZV antigens . -
pubmed
Similar frequencies in patients and controls were observed for
TaqI and BglII RFLPs of the TcR alpha constant segment ( C alpha ) , the latter earlier reported to be associated with
MS . -
pubmed
A previously reported
MS - associated
PssI RFLP of the V alpha 12 and C alpha gene segments could not be confirmed . -
pubmed
The anti - HIV-1 activity of
AS101 as reflected by inhibition of the different catalytic functions associated with viral
RT , in the absence of drug - related toxicity to lymphocytes , together with its immunomodulating activity strongly argues in favor of its evaluation , as a therapeutic agent for
patients with
HIV infection . -
pubmed
These results indicate that : 1 )
Protein deficiency provokes an impairment of
IgA - B cell terminal differentiation . -
pubmed
3 ) The increased number of OX8 + (
CD8 ) and
OX22 + (
CD45R ) IEL might permit induction of intestinal
delayed type hypersensitivity , thereby abrogating oral tolerance of
systemic delayed type hypersensitivity . -
pubmed
Patients with
Krabbe disease and their family members were assayed for
GALC activity in leukocytes or fibroblasts and were classified as affected , carrier , noncarrier , or unknown . -
pubmed
The intensity of the
TMAO resonance for
CRF subjects was correlated with the plasma concentration of
urea ( R = 0.55 ) and
creatinine ( R = 0.74 ) , suggesting that the presence of
TMAO is closely related to the degree of
renal failure . -
pubmed
p75c - myb expression in
leukemia - lymphoma cells correlated with proliferation and differentiation . -
pubmed
[
Serum cholinesterase activity in
stomach carcinoma ] . -
pubmed
The sensitivity of the assay was increased by using either a purer
antibody preparation or the antiserum to the more potent immunogen ; the assay in which pure
antibody to
ST(C ) was used was 2,857 - fold more sensitive in detecting
ST than the assay in which crude antiserum to
ST ( S ) was used . -
pubmed
The activities of 14 different
aminopeptidases , 5
endopeptidases , 4
glycosidases ,
phosphatase ,
esterase , and
ribonuclease (
RNase ) were measured in the muscle and bone of 12 normal controls and 12
dystrophic mice . -
pubmed
Biological significance of
aromatase activity in
human breast tumors . -
pubmed
Human breast carcinomas contain
aromatase , the enzyme necessary for the conversion of
androgens to
estrogens . -
pubmed
If present in sufficient amounts ,
aromatase could catalyze the synthesis of
estrogens from plasma
steroid precursors and produce high
breast cancer tissue concentrations . -
pubmed
To determine the biological importance of
tumor aromatase , we validated a specific and highly sensitive
3H - labeled water release assay for
aromatase and used this to quantitate the amount of
estrogen synthesized in vitro in
breast tumors . -
pubmed
Of 61
human breast tumors studied , 48 contained measurable
aromatase activity , ranging from 5 - 70.5 pmol
estrone formed / g . -
pubmed
Finally , the amount of
aromatase activity present in most
tumors was insufficient to produce biologically meaningful saturation of
estrogen receptors . -
pubmed
These observations suggested that
aromatase , while present in the majority of
breast cancer tissues , may only be biologically important in those few
tumors with very high
aromatase activity . -
pubmed
Kinetic analysis of
bovine factor VIII in the
hemophilic dog . -
pubmed
Bovine factor VIII , which did not contain
platelet aggregating factor activity , was infused into
hemophilic dogs . -
pubmed
Plasma
PRL levels fell in all
patients who showed a reduction in
tumor size ; in 2 other
patients ,
PRL levels were only poorly suppressed , and
tumor size remained unchanged . -
pubmed
In the remaining
patients ,
PRL levels were lowered without convincing evidence of
tumor shrinkage . -
pubmed
Localization of
Cu / Zn and Mn superoxide dismutase in various
thyroid disorders . -
pubmed
The intracellular localization of
Cu / Zn - and Mn - superoxide dismutase (
SOD ) , which catalyze the dismutation of
superoxide radicals (
O2- ) to
O2 and
H2O2 , was studied in the thyroid tissue of various
thyroid disorders by an immunohistochemical technique . -
pubmed
Copper / zinc - SOD in thyroid tissues were identified by immunocytochemical staining in most cases of
papillary carcinoma and in some cases of other
thyroid disorders . -
pubmed
Manganese - SOD stained strongly in
papillary carcinoma and papillary - growing cells in the thyroid tissue of
adenoma and
Graves ' disease . -
pubmed
The concentrations of
Cu /
Zn - and
Mn - SOD in thyroid
tumor tissues and
hyperplastic follicular disorders were significantly higher than those in
normal thyroid tissue when they were compared as a function of protein or deoxyribonucleic acid contents . -
pubmed
The ratio of
Mn - SOD to
Cu / Zn - SOD was significantly higher only in
papillary carcinoma , except for other
thyroid disorders as compared with that in the normal thyroid . -
pubmed
In conclusion ,
SOD seems to be related to cell proliferation and differentiation in the thyroid follicular cell because
Cu / Zn - SOD changes its localization in
tumor and hyperplastic follicular cells and because the
Mn - SOD concentration is increased in
papillary carcinoma or papillary - growing cells . -
pubmed
Therefore
CA 19 - 9 and
Sialyl Le ( x ) are
tumor - associated antigens in the whole colorectum , and
Leb and
Le ( y ) in the distal colon . -
pubmed
Expression of
CA 19 - 9 in primary
tumor provided more prognostic information and risk of
liver metastasis than other Lewis blood group
antigens . -
pubmed
Other forms of
cerebral amyloid angiopathy are exceptional :
hereditary cerebral hemorrhages with
amyloidosis differ from each another in type of fibrillar protein (
cystatine - C , variant of
B protein , transthyretine ) . -
pubmed
Immunohistochemically , most of the
RER - positive cancers were reactive for
cytokeratin ( 22/23 , 96 % ) and
CEA ( 17/23 , 74 % ) , and negative for
NSE ( 2/23 , 9 % ) ,
chromogranin ( 3/23 , 13 % ) and
synaptophysin ( 0/23 , 0 % ) . -
pubmed
In comparison to 46
RER - negative tumors ,
RER - positive cancer had less frequent
CEA expression ( 17/23 , 74 % vs. 44/46 , 96 % , p = 0.01 ) . -
pubmed
Beta - adrenergic antagonists in the prevention of
gastrointestinal rebleeding in
patients with
cirrhosis : a meta - analysis . -
pubmed
Yet , as we report herein , the diverse
gL glycoproteins of
Epstein - Barr virus (
EBV ) and
varicella - zoster virus (
VZV ) were functionally interchangeable , although membrane expression and maturation of
gH were separate functions for these viruses . -
pubmed
Low prevalence of
factor V : Q506 in 41 patients with isolated
pulmonary embolism . -
pubmed
It has been demonstrated that the most common
coagulation defect predisposing to
venous thrombosis , resistance to
activated protein C (
APC ) , is not associated with an increased risk for
pulmonary embolism , but the evidence was based on a functional assay to diagnose
APC resistance and no information about concomitant
deep vein thrombosis was provided . -
pubmed
The aim of our study was to evaluate the prevalence of
factor V : Q506 , the gene mutation responsible for
APC resistance , in patients with symptomatic non - fatal
pulmonary embolism , whether or not associated with
deep vein thrombosis . -
pubmed
The overall prevalence of
factor V : Q506 in 106
patients with
pulmonary embolism was 12.3 % , lower than that found in 106 patients with
deep vein thrombosis ( 22.6 % , OR 0.5 , 95 % CI 0.2 - 1.0 ) but significantly higher than that found in 212 healthy subjects taken as controls ( 2.8 % , OR 4.8 , 95 % CI 1.8 - 13.0 ) . -
pubmed
In conclusion , the prevalence of
factor V : Q506 is high in patients with
pulmonary embolism associated with
deep vein thrombosis , whereas in patients with isolated
pulmonary embolism it is similar to that found in control subjects . -
pubmed
Vitamin E succinate inhibits proliferation of
BT-20 human breast cancer cells : increased binding of
cyclin A negatively regulates
E2F transactivation activity . -
pubmed
Characterization of
human IgG1 monoclonal antibody against
gangliosides expressed on
tumor cells . -
pubmed
A
human IgG1.k monoclonal antibody ( MAb ) designated
GMA1 was developed by fusing pooled lymph node lymphocytes from
cancer patients with the
human lymphoblastoid cell line ,
SHFP-1 . -
pubmed
The
GMA1 MAb reacted with several melanoma and
neuroblastoma cell lines . -
pubmed
Arterial
hypertrophy in response to
hypertension includes increases in the connective tissue proteins
elastin and
collagen . -
pubmed
Adrenal - cortex autoantibodies and autoantibodies to
21 - hydroxylase were found in 81 % of the
patients with autoimmune
Addison ' s disease . -
pubmed
None of the
patients with nonautoimmune
Addison ' s disease had adrenal - cortex autoantibodies or autoantibodies to
21 - hydroxylase . -
pubmed
Steroid - producing cells autoantibodies were found in 26 % of the
patients with autoimmune
Addison ' s disease , and autoantibodies to
17alpha - hydroxylase and/or
P450 side chain cleavage enzyme in 36 % of the
patients . -
pubmed
Steroid - producing cells autoantibodies were found in 11/13 ( 85 % ) of
patients with
idiopathic premature ovarian failure associated with autoimmune
Addison ' s disease , and autoantibodies to
17alpha - hydroxylase and/or
P450 side chain cleavage were found 12/13 ( 92 % ) of
patients ; the only case negative for all these three markers suffered from
Turner ' s syndrome . -
pubmed
Angiotensin II receptor antagonists and
hypertension . -
pubmed
The injections produced
soft tissue lesions characterized by three distinct phases that overlapped or existed simultaneously in one
animal : an initial acute inflammatory reaction characterized by an infiltration of lymphocytes , monocytes and macrophages , a second mesenchymal fibromatous phase characterized by the predominance of spindle - shaped , focally atypical fibroblast - like cells and
collagen , and a third premalignant neovascularization phase characterized by dominant capillary proliferations . -
pubmed
[ In situ localization of
mRNA gelatinases in
cerebral aneurysms ] . -
pubmed
OBJECTIVE : To explore the role of
gelatinases A and B and their tissue inhibitors ,
TIMP-1 and
TIMP-2 , in the formation of
cerebral aneurysm . -
pubmed
RESULTS : The levels of
gelatinase B mRNA were found very high in
cerebral aneurysms , especially in the site of internal elastic lamella . -
pubmed
Gelatinase A TIMP-1 and
TIMP-2 mRNA were not found in both
cerebral aneurysms and normal cerebral arteries . -
pubmed
CONCLUSIONS : Differential patterns of expression can be seen in situ , and tissue
gelatinase B mRNA levels are elevated in
aneurysms , suggesting that
gelatinase B maybe responsible for the destruction of internal elastic lamina or even all laminae of cerebral arteries , leading to
cerebral aneurysms . -
pubmed
Injury was assessed histologically , as well as with Northern blots , probing for the enterocyte differentiation markers
intestinal alkaline phosphatase and
lactase , as well as the gut - epithelial marker
villin . -
pubmed
Intestinal
alkaline phosphatase and
lactase were lost immediately after
ischemia and returned with reperfusion , confirming that the differentiated cells are particularly sensitive to
ischemic injury . -
pubmed
Interferon - alpha-2b and
ribavirin for retreatment of
chronic hepatitis C. -
pubmed
BACKGROUND / AIMS : Subjects with
chronic hepatitis C who fail treatment with
interferon - alpha are generally divided into two groups : " relapsers " who normalized
serum aminotransferase activity and have undetectable viral RNA during treatment and " non - responders " who do not achieve these results . -
pubmed
Our data suggest that an
aromatase inhibitor may be an effective treatment for
ESS . -
pubmed
The deposition of extracellular
beta - amyloid peptide (
A beta ) in the brain is a pathologic feature of
Alzheimer ' s disease . -
pubmed
Serum
endostatin predicts
tumor vascularity in
hepatocellular carcinoma . -
pubmed
To analyze the protective effects of the
aminotetraline derivative
( + /-)-( R , S )- 5,6 - dihydroxy-2 - methylamino-1,2,3,4 - tetrahydro - naphthalene hydrochloride (
CHF-1024 ) , a compound endowed with
DA2 - dopaminergic /
alpha2 - adrenergic receptor agonistic activity , in
myocardial ischemia /
reperfusion damage . -
pubmed
Cardiac mechanics changes were evaluated together with biochemical markers of
cardiac ischemia in perfusate and tissue
tumor necrosis factor - alpha (
TNF - alpha ) . -
pubmed
This anti -
ischemic effect of
CHF-1024 was associated to a decrease in
creatine kinase and
lactate dehydrogenase , both released during heart reperfusion . -
pubmed
These events were concomitant with maintenance of a higher production of
6 - keto - prostaglandin F1alpha The ability of
CHF-1024 to improve postischemic
ventricular dysfunction was correlated with a dose - dependent inhibition of the release of both
norepinephrine ( NE ) , from sympathetic nerve endings , and
TNF - alpha from cardiac tissue . -
pubmed
Soluble intracellular
adhesion molecules (
sICAM-1 ,
sVCAM-1 ) in peripheral blood of
patients with
thyroid cancer . -
pubmed
The aim of this work was estimation of the concentration of soluble
intercellular adhesion molecules (
sICAM-1 ) and
vascular cellular adhesion molecules (
sVCAM-1 ) in the serum of peripheral blood of
patients with
thyroid cancer before operation . -
pubmed
We found statistically significant increase of
sICAM-1 concentration in serum in all forms of
cancer , in comparison with the control group . -
pubmed
Mean concentrations of
sICAM-1 were as follows : in
papillary cancer patients 455.23+/-28.66 vs. 299.62+/-11.54 ng / ml , p<0.05 ; in oxyphilic
cancer 455.60+/-95.21 vs. 299.62+/-11.54 ng / ml , p<0.05 ; in
anaplastic cancer 570.00+/-170.89 vs. 299.62+/-11.54 ng / ml , p<0.05 ; and in
medullary cancer 512.00+/-11.46 vs. 299.62+/-11.54 ng / ml , p<0.05 . -
pubmed
The mean concentration of
sVCAM-1 in serum was statistically significantly higher than in the control group only in case of anaplastic
cancer ( 1033.75+/-86.30 vs. 644.58+/-27.30 ng / ml ; p<0.05 ) . -
pubmed
We evaluated the correlation coefficient between the concentration of
sICAM-1 and
sVCAM-1 in the serum of
patients with
thyroid cancer . -
pubmed
Hemolytic uremic syndrome (
HUS ) is associated with
acute renal failure in
children and can be caused by
Shiga toxin (
Stx)-producing
Escherichia coli . -
pubmed
The ability of
Stx to interact with previously activated platelets may be an important element in understanding the pathogenesis of
HUS . -
pubmed
Apoptosis in
prostate carcinoma before and after neoadjuvant therapy with
LH - RH analog . -
pubmed
This study investigated apoptosis in
prostate cancer before and after neoadjuvant treatment with
LH - RH analog , demonstrating that this therapy induced high
AI and
bax and
survivin overexpression , thus acting as a proapoptotic agent in
prostate cancer . -
pubmed
Highly active antiretroviral therapy ( HAART ) can dramatically decrease
human immunodeficiency virus ( HIV ) load in plasma , increase
CD4 + cell counts , and prolong life for
HIV - seropositive persons . -
pubmed
Suppression of
Peutz - Jeghers polyposis by inhibition of
cyclooxygenase-2 . -
pubmed
Polyps in
PJS patients and in
Lkb1(+/- )
mice that model
PJS polyposis are frequently characterized by elevated
cyclooxygenase-2 (
COX-2 ) . -
pubmed
This study was designed to determine whether
COX-2 inhibition would reduce
tumor burden in
Lkb1 (+/- ) mice or
Peutz - Jeghers patients . -
pubmed
METHODS : Genetic interactions between
Cox-2 and
Lkb1 in
polyp formation were analyzed in
mice with combined deficiencies in these genes . -
pubmed
In
PJS patients ,
COX-2 was inhibited with a daily dose of 2 x 200 mg
celecoxib for 6 months . -
pubmed
RESULTS : Total
polyp burden in
Lkb1(+/- )
mice was significantly reduced in a
Cox-2(+/- ) ( 53 % ) and in a
Cox-2(-/- ) ( 54 % ) background . -
pubmed
CONCLUSIONS : These data establish a role for
COX-2 in promoting
Peutz - Jeghers polyposis and suggest that
COX-2 chemoprevention may prove beneficial in the treatment of
PJS . -
pubmed
Screening for mutations in six genes mapping to 7q ,
CUTL1 ,
SRPK2 ,
SYPL ,
LAMB1 ,
NRCAM and
PTPRZ1 in 48 unrelated individuals with
autism led to the identification of several new coding variants in the genes
CUTL1 ,
LAMB1 and
PTPRZ1 . -
pubmed
Analysis of genetic variants provided evidence for association with
autism for one of the new missense changes identified in
LAMB1 ; this effect was stronger in a subgroup of affected male sibling pair families , implying a possible specific sex - related effect for this variant . -
pubmed
Association was also detected for several polymorphisms in the promoter and untranslated region of
NRCAM , suggesting that alterations in expression of this gene may be linked to
autism susceptibility . -
pubmed
The combination of elevated serum levels of free thyroid hormones with non - suppressed
thyroid - stimulating hormone suggests the differential diagnoses of resistance to thyroid hormone or thyroid - stimulating hormone - secreting
pituitary tumour . -
pubmed
A case report of
hidroacanthoma simplex with an immunohistochemical study of
cytokeratins . -
pubmed
In the group II levels of
BALP and
DPD were assessed twice : before treatment of
hyperthyroidism and after 6 months since euthyroid state had been achieved . -
pubmed
Improvement of the therapeutic index of
adenoviral gene transfer requires the development of strategies to abrogate adenoviral capsid - induced
inflammation and
cytokine production . -
pubmed
The effect of
monomethoxypolyethylene glycol (
MPEG ) conjugation to adenoviral vectors and of
methylprednisolone ( MP ) on innate immunity ,
liver inflammation , and thrombocyte counts was evaluated after transfer of 1011 particles of
E1 / E3 / E4- deleted
adenoviral vector expressing
human apolipoprotein A - I (
apoA - I ) . -
pubmed
This upregulation would potentially allow a similar twofold increase in the transport of other MCAs , including
lactate , during
insulin - induced
hypoglycemia . -
pubmed
Beta2 - adrenergic receptor genetic variants and risk of
sudden cardiac death . -
pubmed
BACKGROUND : Sympathetic activation influences the risk of
ventricular arrhythmias and
sudden cardiac death (
SCD ) , mediated in part by the
beta2 - adrenergic receptor (
B2AR ) . -
pubmed
We investigated whether variation in the
B2AR gene is associated with
SCD risk . -
pubmed
METHODS AND RESULTS : In this study , 4441 white and 808 black Cardiovascular Health Study ( CHS ) participants were followed up prospectively for
SCD and genotyped for
B2AR Gly16Arg and Gln27Glu polymorphisms . -
pubmed
Our findings suggest that
B2AR plays a role in
SCD in
humans . -
pubmed
Study of genetic variation within the
B2AR gene may help identify those at increased
SCD risk . -
pubmed
Deer and
elk with
CWD have extensive aggregates of
PrP(Sc ) not only in the central nervous system , but also in peripheral lymphoid tissues , skeletal muscle , and other organs , perhaps influencing prion shedding . -
pubmed
Genetic polymorphisms in the
Prnp gene may affect
CWD susceptibility , particularly at codon 225 ( S / F ) in
deer and codon 132 ( M / L ) in elk . -
pubmed
Gene therapy with
CX3CL1 /
Fractalkine induces antitumor immunity to regress effectively
mouse hepatocellular carcinoma . -
pubmed
CX3CL1 /
Fractalkine(
FK ) , a
chemokine existing in both secreted and membrane anchored form , was reported to induce suppressive activities in
tumor models . -
pubmed
Immunohistochemistry examination and fluorescence - activated cell sorting analyses revealed both
CD4 + and
CD8 + T cells infiltration within the
tumor together with a marked increase of these cells in the peripheral blood . -
pubmed
We also observed an increased production of
IL-2 and
IFN - gamma in
MM45T.Li - FK tumor tissue . -
pubmed
FK should be considered as a
chemokine suitable for
cancer immunoprevention or gene therapy . -
pubmed
Differential regulation of systemic and intrarenal ( urinary )
ANG systems occurs during blockade , and suppression of the intrarenal system may contribute to reduced
proteinuria . -
pubmed
Thus ,
insulin resistance ,
renal injury , and activation of the intrarenal
ANG system during early aging in normotensive
animals can be averted by
renin -
ANG system blockade . -
pubmed
However ,
oral cavity erosions appeared in December 2004 , and the titer of anti -
Dsg3 autoantibodies in serum elevated , suggesting a transition from PF to
pemphigus vulgaris (
PV ) . -
pubmed
Perhaps the strongest finding in psychiatric genetics to date is the impressive effect that a single genetic variant , in the
aldehyde dehydrogenase 2 gene , has on drinking behaviour and reducing the risk of developing
alcohol dependence . -
pubmed
Using infectivity assays , we found that the longer isoform of
ZAP that contains the
PARP - like domain is a stronger suppressor of
murine leukemia virus expression and
Semliki forest virus infection . -
pubmed
LIGHT induces cell proliferation and inflammatory responses of
rheumatoid arthritis synovial fibroblasts via
lymphotoxin beta receptor . -
pubmed
OBJECTIVE : To investigate the effects of
LIGHT (
lymphotoxin - like , exhibits inducible expression and competes with
herpes simplex virus glycoprotein D for herpes virus entry mediator , a receptor expressed by T lymphocytes ) on the proliferation and gene expression of fibroblast - like synoviocytes ( FLS ) from
patients with
rheumatoid arthritis (
RA ) . -
pubmed
METHODS : We measured
LIGHT levels in RA synovial fluids ( SF ) by ELISA , and compared them with those in
osteoarthritis (
OA ) SF . -
pubmed
RESULTS :
LIGHT was upregulated in both SF and synovium of
RA patients compared with
OA patients . -
pubmed
CONCLUSION : Our findings suggest that
LIGHT signaling via
LTbetaR plays an important role in the pathogenesis of
RA by affecting key processes such as the proliferation and activation of RA - FLS . -
pubmed
Regulation of
LIGHT -
LTbetaR signaling may represent a new therapeutic target for
RA treatment . -
pubmed
OBJECTIVE : To determine plasma
interleukin 6 (
pIL-6 ) , plasma
vascular endothelial growth factor (
pVEGF ) , and serum ( s )
YKL-40 in
patients with early
rheumatoid arthritis (
RA ) and unclassified
polyarthritis (
PA ) , and investigate their relationship with radiographic outcome . -
pubmed
METHODS :
pIL-6 and
pVEGF were determined by ELISA and
sYKL-40 by an in - house radioimmunoassay in 51
patients with early
RA and 21 with PA . -
pubmed
RESULTS : Baseline
pIL-6 ,
pVEGF ,
sYKL-40 ,
C - reactive protein (
CRP ) , and erythrocyte sedimentation rate ( ESR ) were elevated in
RA patients compared to healthy persons ( p & lt ; 0.001 ) , but were not in
patients with
PA . -
pubmed
Patients with early
RA had higher
pIL-6 ( p = 0.007 ) ,
pVEGF ( p = 0.02 ) , and
sYKL-40 ( p = 0.024 ) compared to PA
patients . -
pubmed
The mean value of
pIL-6 during the first and second year were higher in
patients with early
RA with progression in
bone erosions ( n = 14 ) compared to early
RA patients without progression ( n = 30 ; first year 8.4 vs 2.8 ng / l , p = 0.04 ; second year 6.1 vs 3.6 ng / l , p = 0.03 ) . -
pubmed
CONCLUSION : Plasma
IL-6 was the only biomarker related to treatment response and progressive erosive disease in
patients with early
RA , but it may not give additional information compared to
CRP in relation to disease activity and treatment response . -
pubmed
BACKGROUND :
Homeodomain - interacting protein kinase-2 (
HIPK2 ) plays an essential role in restraining
tumor progression as it may regulate , by itself or within multiprotein complexes , many proteins ( mainly transcription factors ) involved in cell growth and apoptosis . -
pubmed
RESULTS :
HIPK2 overexpression in
tumor cells downregulated
VEGF mRNA levels and
VEGF promoter activity . -
pubmed
These findings support the function of
HIPK2 as tumor suppressor and hypothesise a role for
HIPK2 as antiangiogenic tool in
tumor therapy approaches . -
pubmed
Evaluation of the
titin - cap gene (
TCAP ) as candidate for
dilated cardiomyopathy in Irish wolfhounds . -
pubmed
We analyzed the
titin - cap (
TCAP ,
telethonin ) gene as candidate for
DCM . -
pubmed
We conclude that
TCAP can most likely be eliminated as cause for
DCM in IWs . -
pubmed
It has been reported that oral premedication with the
H ( 2 ) receptor antagonist
famotidine augmented intraoperative
hypothermia . -
pubmed
Structural polymorphisms in the
mannose - binding lectin gene are associated with
juvenile idiopathic arthritis . -
pubmed
OBJECTIVE : To investigate the possible association between polymorphisms of the
mannose - binding lectin gene (
MBL2 ) and susceptibility to
juvenile idiopathic arthritis (
JIA ) . -
pubmed
RESULTS : Variant allele frequencies of both codon 52 and 57 polymorphisms in the
MBL2 gene were significantly overrepresented in
JIA ( p=0.001 and p=0.004 , respectively ) . -
pubmed
The frequency of low
MBL genotypes ( XA / XA , YA / YO , XA / YO , and YO / YO ) in
JIA was higher than that in healthy controls ( p=0.001 ) . -
pubmed
Serum
MBL concentrations were found to be significantly lower in
JIA patients versus control subjects ( p=0.001 ) . -
pubmed
The 2 promoter polymorphisms and codon 54 SNP of the
MBL2 gene were not associated with
JIA . -
pubmed
CONCLUSION : Our findings suggest that genetically determined low
MBL levels may predispose children to
JIA in a Hungarian population . -
pubmed
In
Digestive Disease Week 2008 , interesting advances in the treatment of
hepatitis C were presented , especially related to the promising increase in the therapeutic efficacy of the combination of conventional treatment with the
protease inhibitor ,
telaprevir . -
pubmed
Corticosteroids reduce
glial fibrillary acidic protein expression in response to
spinal cord injury in a fetal
rat model of
dysraphism . -
pubmed
Corticosteroids modulate
GFAP synthesis , but their effect in
MM is unclear . -
pubmed
The purpose of this study was to evaluate the
GFAP expression in a fetal
rat model of
dysraphism and the effect of
corticosteroid treatment on this marker and on clinical
neurological disabilities . -
pubmed
RESULTS : All fetuses with
MM in group 1 presented
neurological deficits and glial reactions with
GFAP expression , as opposed to controls and shams . -
pubmed
In group 2 , corticosteroid treatment prevented some
neurological deficits ( 18 - 25 % ) , reducing glial response and
GFAP expression . -
pubmed
CONCLUSIONS : Experimentally induced
dysraphism in the
rat fetus is related to glial response and increased
GFAP expression in the spinal cord . -
pubmed
Notably , irregularities in the expression of
hnRNP A18 , B1 , K , P2 and L have been linked to
cancer and radiosensitivity . -
pubmed
The cell cycle checkpoint status (
p21 ,
p27 ,
p16 ,
Tp53 ) , cell dynamics (
proliferating cell nuclear antigen ,
Ki-67 ,
terminal deoxynucleotidyl transferase - mediated
dUTP -
biotin nick - end labeling , M30 ) , DNA damage (
gamma - H2AX [
H2A histone family , member X ] ) , telomere lengths , chromosomal instability ( micronuclei index ) , and senescence - associated
beta - galactosidase (
SA - beta - Gal ) activity were evaluated using an in situ approach and compared to those in normal liver ( n = 5 ) and liver with
chronic cholestasis ( 34 cases of
hepatolithiasis and three cases of
primary biliary cirrhosis ) . -
pubmed
In
HBV - related
cirrhosis , the
p21 ,
p27 , and
p16 cell cycle checkpoint markers were activated in normal - looking cirrhotic hepatocytes ( NLCH ) , but diminished gradually from LLCC ,
SLCC , to
HCC , with an increase in
Tp53 expression . -
pubmed
Micronuclei ,
gamma - H2AX foci , and net cellular gain were significantly increased from normal hepatocytes , NLCH , LLCC ,
SLCC , to
HCC . -
pubmed
HBV - related
LLCC showed significantly higher
Tp53 labeling index ,
gamma - H2AX labeling index , and micronuclei index ; shorter telomere length ; decreased SA - beta - Gal activity ; and increased net cellular gain compared to
cholestatic LLCC . -
pubmed
Bmi1 is a
MYCN target gene that regulates tumorigenesis through repression of
KIF1Bbeta and
TSLC1 in
neuroblastoma . -
pubmed
A correlation between
MYCN and polycomb protein
Bmi1 expression was observed in primary NB
tumors . -
pubmed
Intriguingly , the above - mentioned
Bmi1 - related regulation of the NB cell phenotype seems not to be mediated only by
p14ARF /
p16INK4a in
NB cells . -
pubmed
Expression profiling analysis using a
tumor - specific cDNA microarray addressed the
Bmi1 - dependent repression of
KIF1Bbeta and
TSLC1 , which have important roles in predicting the prognosis of
NB . -
pubmed
These findings suggest that
MYCN induces
Bmi1 expression , resulting in the repression of
tumor suppressors through Polycomb group gene - mediated epigenetic chromosome modification . -
pubmed
NB cell proliferation and differentiation seem to be partially dependent on the
MYCN /
Bmi1 /
tumor - suppressor pathways . -
pubmed
Further studies are needed to define the cause of the age - related increase in serum
sclerostin levels in
humans as well as the potential role of this increase in mediating the known age - related
impairment in bone formation . -
pubmed
The cellular immunity was evaluated using neutrophil adhesion test ,
cyclophosphamide induced
neutropenia and
carbon clearance assay , whereas , humoral immunity was tested by
mice lethality test ,
serum immunoglobulin estimation and indirect haemagglutination assay in animals . -
pubmed
Influence of aging and
hemorrhage injury on
Sirt1 expression : possible role of
myc -
Sirt1 regulation in mitochondrial function . -
pubmed
Thus , induction of
Sirt1 is likely to produce salutary effects following T - H induced injury and hence ,
Sirt1 may be a potential molecular target for translational research in
injury resolution . -
pubmed
Therefore , aberrant
Wnt7a signaling may contribute to
neurological disorders in which excitatory signaling is disrupted . -
pubmed
METHODS : On the basis of culturing neonatal
rat cardiomyocytes , the model of
hypoxia - reoxygennation was built by using method of Liquid Paraffin covering , the impact of
S1P on apoptosis and p -
Akt and mitochondrial membrane potential were studied by using method of
Propidine Iodide staining and Western blot and Bhodanmine123 staining . -
pubmed
RESULTS :
SiP could reduce apoptosis rate ( P & lt ; 0.01 ) and stabilize the mitochondrial membrane potential ( P & lt ; 0.05 ) and improved the level of p -
Akt1 ( P & lt ; 0.01 ) in
hypoxia / reoxygenation cardiomyocytes significantly . -
pubmed
These capabilities were used to examine the response of
cancer cells to the presence of a ligand (
CXCL12 ) secreted from surrounding cocultured cells . -
pubmed
Extending the reach of
BRAF - targeted
cancer therapy . -
pubmed
Default in plasma and intestinal
IgA responses during acute
infection by simian immunodeficiency virus . -
pubmed
BACKGROUND : Conflicting results regarding changes in mucosal
IgA production or in the proportions of
IgA plasma cells in the small and large intestines during
HIV - infection have been previously reported . -
pubmed
Except in individuals repeatedly exposed to
HIV-1 but yet remaining uninfected ,
HIV - specific
IgAs are frequently absent in mucosal secretions from
HIV - infected patients . -
pubmed
However , little is known about the organization and functionality of mucosal B - cell follicles in
acute HIV / SIV infection during which a T - dependent
IgA response should have been initiated . -
pubmed
RESULTS : Plasma
IgA level was reduced by 46 % by 28 days post
infection ( dpi ) , and no
IgA plasma cells were found within germinal centers of Peyer 's Patches and isolated lymphoid follicles . -
pubmed
CONCLUSION : Our data provide evidence that
SIV is unable to initiate a T - dependent
IgA response during the acute phase of
infection and favors the production of
IgG ( ileum ) or
IgM ( duodenum ) plasma cells at the expense of
IgA plasma cells . -
pubmed
Therefore , an early and generalized default in
IgA production takes place during the acute of phase of
HIV / SIV infection , which might impair not only the virus - specific antibody response but also
IgA responses to other pathogens and vaccines as well . -
pubmed
Understanding the mechanisms that impair
IgA production during
acute HIV / SIV infection is crucial to improve virus - specific response in mucosa and control microbial translocation . -
pubmed
Glucocorticoid ameliorates early
cardiac dysfunction after coronary microembolization and suppresses
TGF - beta1 /
Smad3 and
CTGF expression . -
pubmed
OBJECTIVES : This study was designed to evidence the protective effect of glucocorticoid therapy on
cardiac dysfunction after coronary microembolization ( CME ) , and to clarify its mechanism with the expression of
transforming growth factor - beta 1 (
TGF - beta1)/
Smad3 and
connective tissue growth factor (
CTGF ) . -
pubmed
PRR11 is a novel gene implicated in cell cycle progression and
lung cancer . -
pubmed
In the present study , we isolated and identified a novel gene ,
proline - rich protein 11 (
PRR11 ) , implicated in both cell cycle progression and
lung cancer . -
pubmed
Our results showed that
PRR11 was periodically expressed in a cell cycle - dependent manner , and RNAi - mediated silencing of
PRR11 caused significant S phase arrest as well as
growth retardation in
HeLa cells . -
pubmed
Moreover ,
PRR11 was overexpressed at both mRNA and protein levels in
lung cancer tissues as compared with
normal lung tissues . -
pubmed
Large scale in silico analysis of clinical microarray datasets also indicated that high expression of
PRR11 was significantly associated with poor prognosis in
lung cancer patients . -
pubmed
RNAi - mediated silencing of
PRR11 caused S phase arrest , suppressed cellular proliferation , colony formation ability in
lung cancer cells and inhibited tumorigenic potential in
nude mice . -
pubmed
Knockdown of
PRR11 also inhibited cell migration and invasion ability in
lung cancer cells . -
pubmed
Taken together , our results strongly demonstrated that this newly identified gene ,
PRR11 , had a critical role in both cell cycle progression and tumorigenesis , and might serve as a novel potential target in the diagnosis and/or treatment of
human lung cancer . -
pubmed
RNA - Seq profiling of spinal cord motor neurons from a presymptomatic
SOD1 ALS mouse . -
pubmed
Recent observations that several inherited forms of
ALS involve the RNA binding proteins
TDP43 and
FUS raise the question as to whether RNA metabolism is generally disturbed in
ALS . -
pubmed
Here we conduct whole transcriptome profiling of motor neurons from a
mouse strain , transgenic for a mutant
human SOD1 ( G85R
SOD1 - YFP ) , that develops symptoms of
ALS and paralyzes at 5 - 6 months of age . -
pubmed
Strenuous exercise promotes changes in salivary
IgA and can be associated with a high incidence of
upper respiratory tract Infections . -
pubmed
Hepatitis Be antigen (
HBeAg)-positive
CHB patients whose serum
hepatitis B virus (
HBV ) DNA remained detectable despite at least 6 mo of
LAM +
ADV therapy were included . -
pubmed
Expression and biological role of
cytoglobin in
human ovarian cancer . -
pubmed
Loss of
cytoglobin is found to be involved in the progression of several
human cancers . -
pubmed
In this study , we examined
cytoglobin expression in 118 archived
ovarian cancer specimens using immunohistochemistry . -
pubmed
cytoglobin downregulation positively correlated with advanced FIGO stage and
tumor grade . -
pubmed
In conclusion ,
cytoglobin is downregulated in
ovarian cancers and associated with advanced stage . -
pubmed
Our data provides evidence that
cytoglobin regulates the
ovarian cancer cell proliferation and invasion . -
pubmed
Cross - species analysis of genetically engineered
mouse models of
MAPK - driven
colorectal cancer identifies hallmarks of the
human disease . -
pubmed
Here , we describe a collection of genetically engineered mouse models ( GEMMs ) of sporadic
CRC that combine
lesions frequently altered in
human patients , including well - characterized
tumor suppressors and activators of
MAPK signaling . -
pubmed
We provide evidence that a
Kras signature derived from these GEMMs is capable of distinguishing human
tumors harboring
KRAS mutation , and tracks with poor prognosis in two independent human patient cohorts . -
pubmed
Furthermore , the analysis of a panel of human
CRC cell lines suggests that high expression of the GEMM
Kras signature correlates with sensitivity to targeted pathway inhibitors . -
pubmed
Few studies have compared treatment patterns , healthcare resource utilization ( HRU ) , and costs in patients with metastatic
breast cancer (
mBC ) receiving
HER2 directed therapy . -
pubmed
BACKGROUND AND OBJECTIVE : Two prognostic models to predict overall survival and
thrombosis - free survival have been proposed : International Prognostic Score for
Essential Thrombocythemia (
IPSET ) and IPSET -
Thrombosis , respectively , based on age , leukocytes count , history of previous
thrombosis , the presence of cardiovascular risk factors and the
JAK2 mutational status . -
pubmed
PATIENTS AND METHODS : We have evaluated the clinical data and the mutation status of
JAK2 ,
MPL and
calreticulin of 214
ET patients diagnosed in a single center between 1985 and 2012 , classified according to classical risk stratification , IPSET and IPSET -
Thrombosis . -
pubmed
Both platelet- and endothelial cell - derived
ERp5 support
thrombus formation in a laser - induced
mouse model of
thrombosis . -
pubmed
Protein disulfide isomerase (
PDI ) and
endoplasmic reticulum protein 57 (
ERp57 ) are emerging as important regulators of
thrombus formation . -
pubmed
We show here the involvement of
ERp5 in
thrombus formation using the
mouse laser - injury model of
thrombosis and a specific antibody raised against recombinant
ERp5 . -
pubmed
ERp5 release at the
thrombus site was detected after infusion of
Alexa Fluor 488 - labeled anti -
ERp5 antibody at 0.05 mug / g body weight , a dose that does not inhibit
thrombus formation . -
pubmed
Anti -
ERp5 at 3 mug / g body weight inhibited laser - induced
thrombus formation in vivo by causing a 70 % decrease in the deposition of platelets and a 62 % decrease in
fibrin accumulation compared to infusion of control antibody ( P & lt ; .01 ) . -
pubmed
These results provide evidence for a novel role of
ERp5 in
thrombus formation , a function that may be mediated through its association with
alphaIIbbeta3 . -
pubmed
In fact , clinical studies revealed increased levels of
N / OFQ under
sepsis ,
arthritis , and
Parkinson ' s disease . -
pubmed
Preclinical and clinical studies pointed to the blockade of
NOP receptor signaling as successful strategy for the treatment of
inflammatory diseases . -
pubmed
Activation of peripheral
KCNQ channels relieves
gout pain . -
pubmed
Our data indicate that activation of peripheral
KCNQ channels mediates the
pain relief effects of
BBR , potentially providing a new strategy for the development of more effective therapies for
gout . -
pubmed
Soluble receptors for advanced glycation end products and
receptor activator of NF - kappaB ligand serum levels as markers of
premature labor . -
pubmed
BACKGROUND : This study aimed to determine the relationships between secretory and endogenous secretory receptors for
advanced glycation end products (
sRAGE ,
esRAGE ) ,
sRANKL ,
osteoprotegerin and the interval from diagnosis of threatened
premature labor or
premature rupture of the fetal membranes to delivery , and to evaluate the prognostic values of the assessed parameters for
preterm birth . -
pubmed
The sensitivities of
sRANKL and
sRAGE levels for predicting
preterm delivery were 0.895 and 0.929 with a negative predictive value ( NPV ) of 0.857 and 0.929 , respectively . -
pubmed
Cerdulatinib , a novel dual
SYK /
JAK kinase inhibitor , has broad anti - tumor activity in both ABC and GCB types of
diffuse large B cell lymphoma . -
pubmed
B - cell receptor (
BCR ) and
JAK /
STAT pathways play critical roles in
diffuse large B - cell lymphoma (
DLBCL ) . -
pubmed
Herein , we investigated the
anti - lymphoma activity of
cerdulatinib , a novel compound that dually targets
SYK and
JAK /
STAT pathways . -
pubmed
On a tissue microarray of 62
primary DLBCL tumors , 58 % expressed either phosphorylated
SYK or
STAT3 or both . -
pubmed
Importantly ,
JAK /
STAT and
BCR signaling can be blocked by
cerdulatinib in primary GCB and non - GCB DLBCL
tumor cells that were accompanied by cell death . -
pubmed
Our work provides mechanistic insights into the actions of
cerdulatinib , suggesting that the drug has a broad anti - tumor activity in both ABC and GCB
DLBCL , at least in part by inhibiting
SYK and
JAK pathways . -
pubmed
Rapid Capture Next - Generation Sequencing in Clinical Diagnostics of
Kinase Pathway Aberrations in
B - Cell Precursor ALL . -
pubmed
Comprehensive next - generation sequencing ( NGS ) applications have recently identified various recurrent kinase and cytokine receptor rearrangements in Ph - like B - cell precursor ( BCP )
acute lymphoblastic leukemia (
ALL ) amenable to
tyrosin kinase inhibitor treatment . -
pubmed
Using a standardized bioinformatics algorithm , we identified kinase and cytokine receptor rearrangements in the majority of
ALL patients with high burden of postinduction MRD and enrichment of
IKZF1 mutation or deletion (
IKZF1(del ) ) . -
pubmed
To investigate the possibility that
potassium channels also have a role in the cellular response to
cisplatin , we examined the effect of
cisplatin on the activity of
potassium channels on
CT26 cell , the
colon carcinoma cell line . -
pubmed
RESULTS :
Stretozotocin (
STZ ) only - treated groups exhibited
hyperglycemia ,
polydipsia ,
polyuria ,
weight loss ,
glucose intolerance , low fasting plasma
insulin and reduced hepatic glycogen content compared to the control group . -
pubmed
miR-130b , an onco - miRNA in
bladder cancer , is directly regulated by
NF - kappaB and sustains
NF - kappaB activation by decreasing
Cylindromatosis expression . -
pubmed
Persistent activation of
NF - kappaB signaling is closely related to chronic
inflammation and tumorigenesis . -
pubmed
However , in
cancer cells ,
NF - kappaB may override these feedbacks through special pathways and lead to the sustained activation . -
pubmed
Importantly , we verify that , through deceasing the expression of
Cylindromatosis (
CYLD ) , a
K63 - specific DUB and endogenous blocker of
NF - kappaB signaling , miR-130b can in return sustain the persistent activation of
NF - kappaB , which may promote the malignant progression of
TCC . -
pubmed
Thus , the present study uncovers a potential signaling transduction in which
NF - kappaB is continuously activated , and may provide a novel therapeutic approach for the clinical management of
TCC . -
pubmed
Together these findings reveal that
RORalpha regulates macrophage M2 polarization via activation of
AMPKalpha , which may provide a novel beneficial effect of
RORalpha against
inflammation . -
pubmed
Editorial Comment to Risk stratification using
Bmi-1 and
Snail expression is a useful prognostic tool for
patients with
upper tract urothelial carcinoma . -
pubmed
Membrane - type 1 matrix metalloproteinase (
MT1 - MMP ) is a membrane - bound
MMP that is highly expressed in cells with invading capacity , including fibroblasts and invasive
cancer cells . -
pubmed
This
DDR2 - mediated mechanism is only present in non - transformed mesenchymal cells as
collagen - induced
MT1 -
MMP activation in
HT1080 fibrosarcoma cells and
MT1 -
MMP function in
MDA - MB231 breast cancer cells were not affected by
DDR kinase inhibition . -
pubmed
Amylin receptor ligands reduce the pathological cascade of
Alzheimer ' s disease . -
pubmed
Since
amylin and
amyloid - beta peptide (
Abeta ) share similar beta sheet secondary structure despite not having the same primary sequences , we hypothesized that the accumulation of
Abeta in the brains of
subjects with
Alzheimer ' s disease (
AD ) might compete with
amylin for binding to the
amylin receptor (
AmR ) . -
pubmed
If true , adding exogenous
amylin type peptides would compete with
Abeta and reduce the
AD pathological cascade , improving cognition . -
pubmed
Here we report that a 10 - week course of peripheral treatment with
human amylin significantly reduced multiple different markers associated with
AD pathology , including reducing levels of
phospho - tau , insoluble
tau , two inflammatory markers (
Iba1 and
CD68 ) , as well as cerebral
Abeta . -
pubmed
Amylin treatment also led to improvements in learning and memory in two
AD mouse models . -
pubmed
This is the first report documenting the ability of
amylin treatment to reduce
tauopathy and
inflammation in
animal models of
AD . -
pubmed
The data suggest that the clinical analog of
amylin , pramlintide , might exhibit utility as a therapeutic agent for
AD and other
neurodegenerative diseases . -
pubmed
In the present study , we identified a cellular factor ,
VDAC1 , which was upregulated during
IBDV infection and found to mediate
IBDV polymerase activity . -
pubmed
We designed the experiments to elucidate the antineuroinflammatory property of MWP in
BV2 microglia activated by
beta - amyloid (
Abeta ) , which is a characteristic feature of
Alzheimer ' s disease (
AD ) . -
pubmed
We concluded that
MWP could suppress neuroinflammatory responses in
Abeta - activated BV2 microglia via the
NF - kappaB and
ERK /
p38 MAPK signaling cascades and could prove an effective therapeutic agent for the prevention and treatment of
neuroinflammatory diseases such as
AD . -
pubmed
In vitro and in vivo effect of
PD-1 /
PD - L1 blockade on microglia / macrophage activation and T cell subset balance in
cryptococcal meningitis . -
pubmed
This study aimed to investigate the
PD-1/
PD - L1 signaling pathway and its effects the activation of microglia / macrophage and balancing T cell subsets in
cryptococcal meningitis (
CM ) . -
pubmed
Reducing
insulin via conditional partial gene ablation in adults reverses diet - induced
weight gain . -
pubmed
Excess circulating
insulin is associated with
obesity in
humans and in
animal models . -
pubmed
Herein , we describe the consequences of inducible , partial
insulin gene deletion in a
mouse model in which
animals have already been made
obese by consuming a high - fat diet . -
pubmed
A modest reduction in
insulin production / secretion was sufficient to cause significant
weight loss within 5 wk , with a specific effect on visceral adipose tissue . -
pubmed
This result was associated with a reduction in the protein abundance of the
lipodystrophy gene
polymerase I and transcript release factor (
Ptrf ;
Cavin ) in gonadal adipose tissue . -
pubmed
This study demonstrates that changes in circulating
insulin that are too fine to adversely affect
glucose homeostasis nonetheless exert control over adiposity.-Page , M. M. , Skovso , S. , Cen , H. , Chiu , A. P. , Dionne , D. A. , Hutchinson , D. F. , Lim , G. E. , Szabat , M. , Flibotte , S. , Sinha , S. , Nislow , C. , Rodrigues , B. , Johnson , J. D. Reducing
insulin via conditional partial gene ablation in adults reverses diet - induced
weight gain . -
pubmed
Ectopic Expression of
Snail and
Twist in Ph+
Leukemia Cells Upregulates
CD44 Expression and Alters Their Differentiation Potential . -
pubmed
TGF - beta1 is released during bone remodeling and plays a role in maintaining leukemic stem cells , as well as being implicated in the epithelial - mesenchymal transition ( EMT ) process in most
solid tumors . -
pubmed
The surface receptor
CD44 is involved in cell adhesion , cell migration , and homing of
normal and malignant hematopoietic stem cells . -
pubmed
Elevation of
CD44 expression is considered a marker for a worse prognosis in most
hematological malignancies . -
pubmed
We explored the functions of
Snail and
Twist1 in Ph+
leukemia . -
pubmed
Thus EMT modulators affected proliferation ,
CD44 gene expression and differentiation ability of Ph+
leukemia cells . -
pubmed
Through direct sequencing of the genomic DNA of the
Wiskott - Aldrich syndrome protein (
WASP ) gene , we identified a novel missense mutation in exon 3 of the patient 's
WASP gene ( c. 343 C>T , p. H115 T ) , and the patient was diagnosed with
Wiskott - Aldrich syndrome at 3 months after onset . -
pubmed
Targeting
Bromodomain and Extra - Terminal ( BET ) Family Proteins in Castration - Resistant
Prostate Cancer (
CRPC ) . -
pubmed
Purpose : Persistent
androgen receptor (
AR ) signaling drives
castration - resistant prostate cancer (
CRPC ) and confers resistance to
AR - targeting therapies . -
pubmed
We evaluated how bromodomain and extra - terminal (
BET ) protein inhibitors ( BETi ) abrogate aberrant
AR signaling in CRPC.Experimental Design : We determined associations between
BET expression ,
AR - driven transcription , and
patient outcome ; and the effect and mechanism by which chemical BETi (
JQ1 and
GSK1210151A ; I -
BET151 ) and
BET family protein knockdown regulates
AR - V7 expression and
AR signaling in
prostate cancer models . -
pubmed
Results : Nuclear
BRD4 protein expression increases significantly ( P & lt;= 0.01 ) with castration resistance in same
patient treatment - naive ( median H - score ; interquartile range : 100 ; 100 - 170 ) and
CRPC ( 150 ; 110 - 200 ) biopsies , with higher expression at diagnosis associating with worse outcome ( HR , 3.25 ; 95 % CI , 1.50 - 7.01 ; P & lt;= 0.001 ) . -
pubmed
BRD2 ,
BRD3 , and
BRD4 RNA expression in
CRPC biopsies correlates with
AR - driven transcription ( all P & lt;= 0.001 ) . -
pubmed
Furthermore ,
BETi reduce growth of
prostate cancer cells and patient - derived organoids with known
AR mutations ,
AR amplification and
AR - V7 expression . -
pubmed
Finally ,
BETi , unlike
enzalutamide , decreases persistent
AR signaling and growth ( P & lt;= 0.001 ) of a
patient - derived xenograft model of
CRPC with
AR amplification and
AR - V7 expression . -
pubmed
Angioedema : A Life - threatening Complication of
Tissue Plasminogen Activator . -
pubmed
It can present with
urticaria or
anaphylaxis and is usually associated with
angiotensin - converting enzyme inhibitors ( ACEis ) ,
complement deficiencies , or the side effects of
tissue plasminogen activator (
tPA ) . -
pubmed
Pharmacological manipulation of the
growth hormone secretagogue receptor - type 1a (
GHSR-1a ) receptor has therefore received a lot of attention as a strategy to combat
disorders of appetite and body weight , including age - related
malnutrition and the progressive
muscle wasting syndrome known as
cachexia . -
pubmed
Claudin-7 downregulation induces metastasis and invasion in
colorectal cancer via the promotion of epithelial - mesenchymal transition . -
pubmed
The dysregulation of the tight junctions ( TJs ) protein
claudin-7 is closely related to the development and metastasis of
colorectal cancer (
CRC ) . -
pubmed
The aim of this study was to investigate the expression of
claudin-7 and characterize the relationship between
claudin-7 expression and epithelial - mesenchymal transition ( EMT ) in
CRC . -
pubmed
In this study , the expression of
claudin-7 ,
E - cadherin ,
vimentin and
snail-1 was detected by immunohistochemistry ( IHC ) in a set of 80
CRC specimens comprising 20 specimens each of well - differentiated , moderately differentiated , poorly differentiated and
liver metastases tissues . -
pubmed
The results revealed that the expression of
claudin-7 was downregulated as
CRC tissue differentiation grade decreased , and that low
claudin-7 expression corresponded to the downregulation of
E - cadherin ( r = 0.725 , p & lt ; 0.001 ) and upregulation of
vimentin ( r = -0.376 , p = 0.001 ) and
snail-1 ( r = -0.599 , p & lt ; 0.001 ) . -
pubmed
In conclusion , the expression of
claudin-7 in
CRC is downregulated as differentiation grade decreases . -
pubmed
Claudin-7 downregulation may promote the invasion and metastasis of
CRC by regulating EMT . -
pubmed
Recurrent self - limited attacks of
fever and short - lived
inflammation in the serosal membranes , joints , and skin are the leading features of
familial Mediterranean fever (
FMF ) , the most common
autoinflammatory disorder in the world , transmitted as autosomal recessive trait caused by
MEFV gene mutations . -
pubmed
Their consequence is an abnormal function of
pyrin , a natural repressor of
inflammation , apoptosis , and release of
cytokines . -
pubmed
FMF - related mutant pyrins are hypophosphorylated following
RhoA GTPases ' impaired activity and show a propensity to relapsing uncontrolled
systemic inflammation with inappropriate response to inflammatory stimuli and leukocyte spread to serosal membranes , joints or skin . -
pubmed
Furthermore ,
FMF phenotype 3 is referred to the presence of two
MEFV mutations with neither clinical signs of
FMF nor
AA amyloidosis . -
pubmed
Many recent studies have also shown that anti -
interleukin-1 treatment is the best therapeutic option for
FMF patients nonresponsive or intolerant to
colchicine . -
pubmed
In this study , we explored the biological functions of small nucleolar RNA host gene 12 (
SNHG12 ) and investigated the interaction between miR-133b and
SNHG12 in the progression of
PCa . -
pubmed
We detected
SNHG12 expression level in
PCa cells and tissues , and then analyzed its clinical significance , which revealed that
SNHG12 has the potent to predict prognosis of
PCa . -
pubmed
Bioinformatic analysis revealed that
SNHG12 was closely related to the progression of
PCa and could target candidate microRNA ( miR-133b ) . -
pubmed
After transfecting
SNHG12 silencing plasmid and miR-133b mimic / sponge , biological function assays were conducted and results illustrated that
SNHG12 associated with miR-133b exerted biological effects on
cancer cell growth , migration , and invasion . -
pubmed
Direct interactions between miR-133b and
SNHG12 have been found and
SNHG12 acts as an oncogene to promote tumorigenesis of
PCa by sponging tumor suppressor gene miR-133b . -
pubmed
HC106A inhibits
Mtb survival during
hypoxia - induced
NRP ; however , HC104A did not inhibit survival during
NRP . -
pubmed
First
maternal uniparental disomy for chromosome 2 with
PREPL novel frameshift mutation of
congenital myasthenic syndrome 22 in an infant . -
pubmed
Eight such cases have already been reported , while maternal
uniparental disomy with a
PREPL pathogenic mutation has never been involved . -
pubmed
CONCLUSION : To date , nine patients with
CMS22 have been reported including our patient , and we report the youngest and the first
UPD(2)mat with
PREPL novel homozygous pathogenic mutation case , which expand the mutation spectrum of
PREPL gene . -
pubmed
In contrast ,
Cushing pituitary tumors , both overt and subclinical cases , had higher
CD8 + T cells fractions than GH
tumors ,
prolactinomas ,
hyperthyroid tumors , and silent
tumors . -
pubmed
The results revealed that body weights , symptom scores , the levels of red blood cell , white blood cell , lymphocyte , spleen and thymus indexes , and three
cytokines (
TNF - alpha ,
IL-6 ,
IFN - gamma ) in
honey - processed
Astragalus treated
rats were improved in comparison with
spleen qi deficiency rats . -
pubmed
TP53 Arg72Pro polymorphism and
neuroblastoma susceptibility in eastern Chinese children : a three - center case - control study . -
pubmed
TP53 is a
tumor suppressor gene that regulates cell growth , apoptosis and DNA repair . -
pubmed
Previous studies have reported the contribution of
TP53 Arg72Pro ( rs1042522 C > G ) polymorphism to pathogenesis of
multiple tumors . -
pubmed
No significant association was found between the
TP53 gene rs1042522 C > G polymorphism and
neuroblastoma susceptibility in the overall analysis ( CG vs. CC : adjusted OR=0.92 , 95 % CI=0.70 - 1.22 , P=0.567 ; GG vs. CC : adjusted OR=0.99 , 95 % CI=0.69 - 1.42 , P=0.947 ; CG / GG vs. CC : adjusted OR=0.94 , 95 % CI=0.72 - 1.23 , P=0.639 ; or GG vs. CC / CG : adjusted OR=1.04 , 95 % CI=0.75 - 1.43 , P=0.814 ) and stratified analysis by age , gender , sites of origin , and clinical stages . -
pubmed
The
TP53 gene rs1042522 C > G polymorphism may not be a risk factor for
neuroblastoma in eastern Chinese children . -
pubmed
Future studies are needed to confirm this negative result and to reveal additional functional
TP53 variants predisposing to
neuroblastoma . -
pubmed
Day 3 response was achieved in 55 % ( n = 11/20 ) , with significant reductions in stool frequency ,
rectal bleeding and
CRP ( P < 0.01 ) . -
pubmed
Vascular endothelial growth factor (
VEGF ) is an angiogenesis - promoting factor that can mediate
allergic airway inflammation and can promote airway epithelial cells ( AECs ) proliferation , but it is not clear whether it affects the engulfment of apoptotic cells by AECs . -
pubmed
Since engulfment of apoptotic cells by AECs is an important mechanism for airway inflammation regression ,
VEGF inhibition of the engulfment of apoptotic cells by airway epithelial cells may be important for mediating
allergic airway inflammation . -
pubmed
PTSD is associated with increased DNA methylation across regions ofHLA - DPB1 and
SPATC1L. -
pubmed
This study supports an emerging literature linking
PTSD risk to genetic and epigenetic variation in the
HLA region . -
pubmed
FNDC1 Promotes the Invasiveness of
Gastric Cancer via
Wnt /
beta - Catenin Signaling Pathway and Correlates With Peritoneal Metastasis and Prognosis . -
pubmed
Our previous study found that
FNDC1 has a higher frequency of mutations in
patients with
PM by high - throughput sequencing assay , suggesting that it may be associated with
GC invasion and
PM , however the specific mechanism remains unclear . -
pubmed
Methods : First , the correlation between
FNDC1 and PM and prognosis of
GC was clarified by bioinformatics and clinicopathological analysis . -
pubmed
Next , the effect of
FNDC1 expression on the invasion and metastasis ability of
GC was investigated in vivo and in vitro . -
pubmed
Results :
FNDC1 was highly expressed in
GC and was associated with
PM and poor prognosis . -
pubmed
FNDC1 was also associated with epithelial - mesenchymal transition ( EMT ) in
GC cells . -
pubmed
Through in vivo and in vitro experiments , it was clarified that knockdown of
FNDC1 could inhibit the proliferation , invasion , and migration of
GC cells . -
pubmed
Conclusion :
FNDC1 may be associated with the invasion of
GC and PM after surgery . -
pubmed
FNDC1 was highly expressed in
GC tissues and cell lines , while significantly associated with poor DFS and OS in
GC patients . -
pubmed
Both univariate and multivariate analyses suggested that the expression of
FNDC1 was an independent factor for
GC . -
pubmed
FNDC1 may promote EMT in
GC cells through the regulation of Wnt /
beta - catenin signaling pathway . -
pubmed
FNDC1 has the potential to be used as a predictor of
PM and may also be studied in depth as a therapeutic target for
GC , which has potential clinical utility and is worthy of further validation . -
pubmed
The histaminergic system ,
corticotropin - releasing hormone ,
cyclic GMP - protein kinase G pathway , and intercellular communication in the cerebellar immune system were some of the most relevant enriched pathways in
HA rats . -
pubmed
[
Immunoglobulins of the bronchial mucosa in acquired
bronchiectasis and in
bronchopulmonary carcinomas ] . -
pubmed
Adrenocorticotrophin responses to
hypoxaemia in fetal
sheep are sustained in the presence of
naloxone . -
pubmed
We have examined the effects of fetal
hypoxaemia , produced by reducing the percent
oxygen in maternal inspired air , on fetal plasma concentrations of
corticotrophin releasing hormone ( CRH ) , adrenocorticotrophin (
ACTH ) and
cortisol and determined the effects of an
opioid receptor antagonist ,
naloxone on these responses . -
pubmed
Hypoxaemia ( fetal PO2 , 15 - 18 mmHg ) for 60 min provoked a significant ( P & lt ; 0.05 ) increase in fetal plasma
ACTH and
cortisol concentrations at days 125 - 130 of pregnancy , but did not affect circulating CRH . -
pubmed
There was no effect of
naloxone administered either intravenously ( 1.25 mg bolus followed by a 2.5 mg / h continuous infusion for one hour ; fetal body weight approximately 2.5 Kg ) or via the lateral cerebral ventricle ( 50 micrograms bolus followed by a 100 micrograms / h infusion for one hour ) on this pattern of
ACTH and
cortisol change nor on the lack of
CRH response to
hypoxaemia . -
pubmed
We conclude that the increase in fetal ACTH and
cortisol in response to acute
hypoxaemia is not accompanied by an increase in systemic
CRH concentrations , nor is the response dependent on short - term opioid regulation . -
pubmed
Relationship between
somatomedin - C and
growth hormone levels in
acromegaly : basal and dynamic evaluation . -
pubmed
The relationship between basal and stimulated
plasma GH and
somatomedin - C (
SmC ) levels in
acromegalic patients was evaluated . -
pubmed
Our data indicate an overall dependency of plasma
SmC levels on plasma GH levels in
acromegaly , although similar
GH levels may have differing
somatomedin - stimulating activities . -
pubmed
In evaluating pharmacological or surgical treatments of
acromegaly , a single
plasma SmC value can reliably replace several plasma
GH determinations . -
pubmed
Thus , lymphocytapheresis may be an alternative therapy for cases of severe
aplastic anemia for those
patients who have no compatible donor for bone marrow transplantation and when
antithymus globulin is not available . -
pubmed
Coagulase - negative
staphylococcal sepsis in infants . -
pubmed
Estrogen and progesterone receptors are not increased in generalized essential
telangiectasia . -
pubmed
[ Study of serum
pepsinogen fractions in
patients with
duodenal ulcer ] . -
pubmed
[ Behavior of
factor XIII in progressive
chronic polyarthritis ] . -
pubmed
[
Can growth - stimulating immunoglobulins (
TGI ) explain sporadic
euthyroid goiters ? ] -
pubmed
In
patients with
primary myxoedema and
thyroid atrophy , existence of TGI - blocking
IgGs has also been demonstrated . -
pubmed
These observations raise several points : --relationship of TGI to other thyroid antibodies , specially to
anti - TSH receptor antibodies ; --is " simple "
goitre , either diffuse or nodular , an
auto - immune thyroid disorder ? -
pubmed
Ribonucleotide reductase in cultured
mouse lymphoma cells . -
pubmed
The
pif region of the
F factor includes two genes ,
pifA and
pifB , that lead to
abortive T7 infection . -
pubmed
Bicistronic
retroviral vector reveals capacity of
v - erbA to induce
erythroleukemia and to co - operate with
v - myb . -
pubmed
In contrast , no
leukemia was observed with a
myb IRES virus , with spliced vectors containing
v - erbA alone or
v - erbA in combination with
v - myb , nor with
erbA IRES and
erbA / myb IRES viruses produced in the absence of helper virus . -
pubmed
These results show that
v - erbA is capable of inducing an
erythroleukemia when expressed by a high titer bicistronic retrovirus under conditions of virus spreading and that its in vitro and in vivo transforming potential can be enhanced by
v - myb . -
pubmed
Alkaloidal glycosidase inhibitors ( AGIs ) as the cause of
sporadic scrapie , and the potential treatment of both
transmissible spongiform encephalopathies (
TSEs ) and
human immunodeficiency virus ( HIV ) infection . -
pubmed
As
HIV infection progresses , infected clone numbers rise , the antigenic diversity of
gp120 may rise as would antibody production , trying to keep pace . -
pubmed
Approximately 60 % of
patients with
SMS have high titers of autoantibodies against the enzyme
glutamic acid decarboxylase . -
pubmed
Similar to
SMS , the majority of
patients with
IDDM have autoantibodies against
glutamic acid decarboxylase at or before
diabetes onset , although usually at a lower titer and with a different reaction pattern than patients with
SMS . -
pubmed
Patients with
SMS carried the IDDM - protective DQB1 * 0602 allele and other sequence - related
DQB1 * 06 alleles with the same frequency observed in controls . -
pubmed
Five of 8 ( 62.5 % )
SMS patients lacking a DQB1 * 06 allele were
diabetic in contrast to only 2 of 10 ( 20 % ) with a DQB1 * 06 allele ( P = 0.08 ) , suggesting that the presence of DQB1 * 0602 or other
DQB1 * 06 alleles may be associated with a reduced prevalence of
diabetes among patients with
SMS . -
pubmed
Investigation of methylation at
Hha I sites using the hypervariable probe M27 beta allows improved clonal analysis in
myeloid leukaemia and demonstrates differences in methylation between leukaemic and remission samples . -
pubmed
A monoclonal or oligoclonal pattern could be obtained by digestion with
Hha I in 18/22 ( 82 % ) patients with
acute myeloid leukaemia who had previously shown hypermethylation of both alleles using
Hpa II , although in six of these patients differences in methylation could still be demonstrated between leukaemic and remission samples . -
pubmed
The studies also provide useful reagents for the molecular genetic analysis of the role of the
topoisomerase within the context of
vaccinia virus infection . -
pubmed
We refer a case of a 57 - year - old
woman with an acute
myocardial infarction of the anterior wall , treated with
rt - PA ,
aspirin and
heparin . -
pubmed
The aim of this work was to investigate whether free radical reactions play a role in
beta - amyloid neurotoxicity . -
pubmed
In these conditions , where only the longest exposure induced
neuronal death ,
superoxide dismutase activity was increased after acute exposure but no change was detected after chronic treatments , whereas a different pattern was observed for
glutathione peroxidase . -
pubmed
In conclusion , our results show that oxidative stress and free radical production are linked to
beta 25 - 35 exposure and may contribute to neurodegenerative events associated with
beta - amyloid deposits in
Alzheimer ' s disease . -
pubmed
Increased
transforming growth factor beta (
TGF - beta ) immunoreactivity is independently associated with
chronic injury in both consequential and primary
radiation enteropathy . -
pubmed
PURPOSE :
Radiation enteropathy is characterized by sustained increase in
transforming growth factor beta (
TGF - beta ) immunoreactivity and connective tissue mast cell ( CTMC )
hyperplasia that may be responsible for progressive
fibrosis and lead to clinical complications . -
pubmed
Histopathologic changes were assessed with a
radiation injury scoring system ( RIS ) , total
TGF - beta immunoreactivity was quantified with computerized image analysis , and CTMC
hyperplasia was assessed in toluidine blue - stained sections . -
pubmed
RESULTS :
TGF - beta immunoreactivity and CTMC
hyperplasia colocalized in areas of injury and were highly significantly correlated . -
pubmed
Increased fraction size and decreased overall treatment time were associated with increased RIS ( p & lt ; 0.01 and p & lt ; 0.00001 ) , increased
TGF - beta immunoreactivity ( p = 0.01 andp & lt ; 0.001 ) , and degree of CTMC
hyperplasia ( p = 0.01 and p & lt ; 0.001 ) . -
pubmed
TGF - beta immunoreactivity was independently associated with chronic intestinal wall
fibrosis ( p = 0.003 ) . -
pubmed
CONCLUSION : This in vivo study supports in vitro evidence linking increased
TGF - beta immunoreactivity and
mast cell hyperplasia and strongly suggests their involvement in the molecular pathogenesis of both primary and consequential
radiation enteropathy . -
pubmed
Tissue factor is the primary cellular initiator of
blood coagulation via interaction with
coagulation factor VII . -
pubmed
Aberrant expression of
tissue factor is responsible for
thrombosis during
septic shock ,
atherosclerosis and
cancer . -
pubmed
However , neither
IL-1 alpha nor
IL-1 beta are
neurotoxic per se in vivo , so other
IL-1 related ligands may be important in neurodegeneration . -
pubmed
The
cytokine interleukin-18 ( also called
interferon gamma inducing factor ,
IGIF ) was first isolated from the liver of
mice during
toxic shock . -
pubmed
These data indicate a role for
Fas - mediated signaling in the programmed cell death that occurs in response to
H. - pubmed
For stage II
patients tumor MYCN gene amplication , unfavorable histopathology , an age greater than 2 years , and positive lymph nodes predicted a lower OS ( P & lt;.05 ) . -
pubmed
In
children with
localized neuroblastoma , a subset of
patients that are at higher risk for death can be defined as those with stage II disease who have
tumor MYCN amplification or who are & gt;/= 2 years of age with either unfavorable histopathology or positive lymph nodes . -
pubmed
Mutations in the
chloride channel ,
ClC-5 , have been described in several
inherited diseases that result in the formation of
kidney stones . -
pubmed
Insulin increases renal
sodium reabsorption which may contribute to
hypertension . -
pubmed
We describe a 73 - year - old
patient admitted to our hospital because of
fatigue ,
weight loss , and an increased
alkaline phosphatase level . -
pubmed
BACKGROUND : Observations in
patients with functional mutations of the
norepinephrine transporter (
NET ) gene suggest that impaired
norepinephrine uptake may contribute to
idiopathic orthostatic intolerance . -
pubmed
CONCLUSIONS : Selective
NET blockade creates a phenotype that resembles
idiopathic orthostatic intolerance . -
pubmed
Our study also suggests that
NET inhibition might be useful in preventing
vasovagal reactions . -
pubmed
The analyses of
IgH rearrangement prove the clonality of
lymphoproliferative disorders giving a powerful approach to the B - cell origin identification of cell proliferation . -
pubmed
RESULTS :
Cryoglobulinemia was detected in 20 % of all
chronic hepatitis C virus infected patients and
IgH rearrangement was observed in 10.29 % ( 7/68 ) , 4/7 patients ( 57.14 % ) suffered from
cryoglobulinemia . -
pubmed
Exercise , diet , and childhood
obesity : the
GH - IGF - I connection . -
pubmed
Observed abnormalities in the
growth hormone ( GH )- insulin - like growth factor - I (
IGF - I ) axis in obese
adults and the impact of exercise on the
GH - IGF - I system are of particular relevance to the growing
obese child . -
pubmed
As cholinergic mechanisms may be at least partially responsible for
hallucinations and
delusions in
Parkinson ' s disease (
PD ) , we conducted an open study in 8
PD patients to assess the efficacy and tolerability of the
cholinesterase inhibitor
donepezil , 5 mg at bedtime for two months , in the treatment of these complications . -
pubmed
The objective of this study was to investigate the prognostic value of
T - cell receptor - delta 1 (
TCR delta 1 ) expression in primary
cutaneous T - cell lymphomas . -
pubmed
TCR delta 1 cellular expression was assessed in skin biopsy specimens of 104
individuals with
cutaneous T - cell lymphoma by immunohistochemistry . -
pubmed
TCR delta 1 expression in primary
cutaneous lymphomas is an independent prognostic factor associated with decreased survival . -
pubmed
Average blood pressure readings , laboratory measures of
glycosylated hemoglobin , and information on whether the respondent was taking medication for
hypertension or
diabetes are used to validate respondents ' reports of high blood pressure and
diabetes . -
pubmed
Univariate and multivariate analyses predicted systolic and diastolic
sodium sensitivity based on interactions among demographic factors ( age , gender , race , body mass index ) and
hypertensive type [
low - renin (
LR ) , modulator ( M ) , non - modulator ( NM ) ] . -
pubmed
DA-8159 , a new
PDE5 Iihibitor , induces penile erection in conscious and
acute spinal cord injured rabbits . -
pubmed
T9.F
gliomas showed dramatic losses of
CD4 +
CD8 + ( DP ) thymocytes . -
pubmed
The
toxicity of
tumor necrosis factor - alpha upon cholinergic neurons within the nucleus basalis and the role of
norepinephrine in the regulation of
inflammation : implications for
Alzheimer ' s disease . -
pubmed
The therapies now approved for
HIV - infection inhibit one of two viral - specific enzymes ,
reversetranscriptase or
protease . -
pubmed
Differential expression of
S100 gene family in
human esophageal squamous cell carcinoma . -
pubmed
PURPOSE : To study the differential expression of the
S100 gene family at the RNA level in
human esophageal squamous cell carcinoma (
ESCC ) , and to find the relationship of the
S100 gene family with
ESCC . -
pubmed
Then , the differential expression of 16
S100 genes was examined by semiquantitative reverse transcription - polymerase chain reaction ( RT - PCR ) in 62 cases of
ESCC versus the corresponding
normal esophageal mucosa . -
pubmed
RESULTS : Eleven out of 16
S100 genes were significantly downregulated ( p<0.05 ) in
ESCC versus the
normal counterparts such as
S100A1 ,
S100A2 ,
S100A4 ,
S100A8 ,
S100A9 ,
S100A10 ,
S100A11 ,
S100A12 ,
S100A14 ,
S100B , and
S100P genes . -
pubmed
Moreover , the
S100B gene was significantly correlated with histological differentiation of
ESCC ( p=0.0247 ) , and the deregulation of some
S100 genes was closely correlated ( p<0.05 ) , such as
S100A10 /
S100A11 ,
S100A2 /
S100A8 ,
S100A2 /
S100A14 ,
S100A8 /
S100A14 , and
S100A2 /
S100P etc . -
pubmed
CONCLUSIONS : The
S100 gene family is closely associated with
ESCC . -
pubmed
Gene therapy using replication - defective
herpes simplex virus vectors expressing
nerve growth factor in a
rat model of
diabetic cystopathy . -
pubmed
In the present study , the effects of gene therapy , using replication - defective herpes simplex virus type 1 ( HSV-1 ) vectors to deliver and express the
nerve growth factor (
NGF ) gene (
HSV - NGF ) on tissue
NGF levels and bladder function , were evaluated in
streptozotocin (
STZ)-induced
diabetic rats . -
pubmed
Diabetic rats exhibited a significant decrease in
NGF levels in the bladder and lumbosacral dorsal root ganglia ( DRG ) detected by enzyme - linked immunosorbent assay and displayed marked
bladder dysfunction 12 weeks after
STZ injection . -
pubmed
Along with the restoration of tissue
NGF expression , in metabolic cage studies and cystometry , HSV -
NGF - injected
rats also showed significantly reduced bladder capacity and postvoid residual volume than
diabetic rats injected with the control vector ( HSV -
lacZ ) , indicating that voiding function was improved after
HSV vector - mediated
NGF gene delivery . -
pubmed
Thus ,
HSV vector - mediated
NGF gene therapy may prove useful to restore decreased
NGF expression in the bladder and bladder afferent pathways , thereby improving hypoactive bladder function in
diabetes . -
pubmed
Single
nucleotide polymorphisms of the
IL18 gene are associated with
atopic eczema . -
pubmed
BACKGROUND :
Human IL-18 is an inflammatory cytokine that plays a role in
atopic diseases , such as
atopic eczema (
AE ) , by enhancing
IL-4 and
IL-13 production and stimulating the synthesis of
IgE. -
pubmed
OBJECTIVE : To evaluate associations of polymorphisms in the
IL18 gene on chromosome 11q22 with
AE , we performed genotyping for single
nucleotide polymorphisms ( SNPs ) in the
IL18 gene in 225
patients with
AE and 175 healthy control volunteers . -
pubmed
On the functional level , the amount of
IL-18 in the supernatants of PBMCs of
patients with
AE stimulated with
Staphylococcus aureus enterotoxin B was significantly higher than that in healthy control subjects . -
pubmed
In parallel , the amount of active
IL-18 in the sera of
patients with
AE was enhanced at the exacerbation of their disease . -
pubmed
CONCLUSION : In conclusion , our data suggest that SNPs in the
IL18 gene might be involved in the development of
AE by contributing to a functional dysregulation of the
IL-18 production in vivo . -
pubmed
Production of
indoleamine 2,3 - dioxygenase (
IDO ) by
tumor cells , leading to
tryptophan depletion and production of immunosuppressive metabolites , may facilitate immune tolerance of
cancer . -
pubmed
Patients who enrolled in the analyzed trials were aged & gt ; or = 15 years with chronic
plaque psoriasis for & gt ; or = 12 months that involved & gt ; or = 10 % of body surface area , and
CD4 + T lymphocyte counts above the lower limit of normal ( & gt;404 cells / microL ) . -
pubmed
The incidence of
infections was stratified according to
CD4 + T lymphocyte counts ( & lt;250 cells / microL vs & gt ; or = 250 cells / microL ) . -
pubmed
The incidence of
infections appeared to be unrelated to
CD4 + T lymphocyte counts . -
pubmed
Production of monoclonal antibodies specific for native
equine IgE and their application to monitor total serum
IgE responses in Icelandic and non - Icelandic
horses with insect bite
dermal hypersensitivity . -
pubmed
IgE and mast cells have a central role in immunity to
parasites and the pathogenesis of
allergic diseases in
horses and other
mammals . -
pubmed
Total serum
IgE of healthy
horses was compared with that of
horses with
insect bite dermal hypersensitivity (
IBDH ) an
allergic reaction to the bites of blood feeding insects of Culicoides or Simulium spp . -
pubmed
In the present study Icelandic
horses with
IBDH had significantly higher total
IgE than healthy Icelandic
horse controls ( P<0.05 ) . -
pubmed
By contrast in
horses of other breeds the difference in total serum
IgE between those affected with
IBDH and healthy controls was not statistically significant . -
pubmed
Thereafter the total serum
IgE remained low in Icelandic
horses that remained healthy but rose significantly ( P<0.05 ) in those that developed
IBDH . -
pubmed
The survival neurons in the hippocampal CA1 region were less ( 100 + /- 27 / mm vs 183 + /- 8 / mm ; P & lt ; 0.05 ) , as well as the
AchE - positive unit and
NOS - positive neurons ( 18.50 + /- 2.24 % vs 27.50 + /- 2.18 % and 19.25 + /- 4.33 vs 33.75 + /- 5.57 respectively ; P & lt ; 0.05 ) after
HIBD . -
pubmed
Thiorphan , a
neutral endopeptidase inhibitor used for
diarrhoea , is neuroprotective in newborn
mice . -
pubmed
Racecadotril , which is rapidly metabolized to its active metabolite
thiorphan , is a
neutral endopeptidase (
NEP ) inhibitor used in clinical practice for
diarrhoea with a remarkable safety profile . -
pubmed
Intraperitoneal administration of
thiorphan reduced
ibotenate - induced
cortical lesions by up to 57 % and cortical
caspase-3 cleavage by up to 59 % . -
pubmed
Further supporting the neuroprotective effect of pharmacological blockade of
NEP ,
mouse pups with a genetic deletion of
NEP displayed a significantly reduced size of the
ibotenate - induced
cortical grey matter lesion when compared with wild - type
animals . -
pubmed
Recent genetic evidence has linked mutations in
hTHTR1 with the manifestation of
TRMA (
thiamine - responsive
megaloblastic anaemia ) , a condition also associated with
diabetes mellitus ,
sensorineural deafness and
retinal disorders . -
pubmed
To examine how mutations in
hTHTR1 impair
thiamine accumulation , we have investigated the targeting and functional properties of several different
hTHTR1 mutants in
human cell lines derived from epithelia relevant to
thiamine absorption or tissues implicated in
TRMA pathology . -
pubmed
These constructs encompassed two newly identified point mutations ( P51L and T158R ) and two truncations of
hTHTR1 identical with those found in
TRMA kindreds ( W358X and Delta383fs ) . -
pubmed
[ Detection of multidrug resistance - associated proteins
MRP2 ,
MRP3 , and
MRP5 mRNA expressions in
hepatocarcinoma cells using SYBR real - time PCR ] . -
pubmed
CONCLUSION :
MRP2 might play a role in the intrinsic drug resistance , and
MRP3 and
MRP5 are related to the acquired drug resistance of
hepatocellular carcinoma . -
pubmed
Treatment with
apo B peptide vaccines inhibits
atherosclerosis in
human apo B-100 transgenic mice without inducing an increase in peptide - specific antibodies . -
pubmed
DESIGN :
LDL receptor(-/-)/
human apo B-100 transgenic
mice were immunized with native
human apo B-100 peptides
p45 or
p210 at 6 , 9 and 11 weeks and the extent of
atherosclerosis determined by en face Oil Red O staining of the aorta at 25 weeks . -
pubmed
Immunization with native
p45 and
p210 reduced
atherosclerosis by 66 % ( P & lt ; 0.02 ) and 59 % ( P = 0.06 ) , respectively . -
pubmed
CONCLUSIONS : Immunization with
apo B peptide - based vaccines inhibits
atherosclerosis in
mice expressing
human apo B-100 suggesting that they can interact with their target as expressed in
humans . -
pubmed
[ The relationship between
apolipoprotein E genotype and
hypertriglyceridemia - associated recurrent acute
pancreatitis ] . -
pubmed
OBJECTIVE : To explore the relationship of
apolipoprotein E (
ApoE ) genotype with
hypertriglyceridemia - associated recurrent acute
pancreatitis . -
pubmed
METHODS : Taking the fasting serum
triglyceride ( TG ) level & gt ; or = 2.3 mmol / L as
hypertriglyceridemia ,
ApoE genotypes in 115
patients with
hypertriglyceridemia - associated recurrent acute
pancreatitis were assessed by polymerase chain reaction . -
pubmed
CONCLUSIONS :
Apo epsilon 2 and
epsilon 4 alleles are closely related to moderate - severe
hypertriglyceridemia - associated recurrent acute
pancreatitis . -
pubmed
Silencing of
lToll did not impair the ability of non - specific dsRNA to trigger protection from
white spot syndrome virus and did not increase the shrimp susceptibility to
viral infection , when compared to controls . -
pubmed
It has been shown that
diabetes - induced
fetal abnormalities are accompanied by some metabolic disturbances including elevated
superoxide dismutase (
SOD ) activity , reduced levels of
myoinositol and
arachidonic acid and inhibition of the
pentose phosphate shunt pathway . -
pubmed
METHODS :
Rabbit cells from
NP and
AF were isolated and their phenotype was compared with that of AC by real - time PCR analysis of type I (
COL1A1 ) , II (
COL2A1 ) and V (
COL5A1 )
collagens ,
aggrecan transcript (
AGC1 ) ,
matrix Gla protein (
MGP ) and
Htra serine peptidase 1 (
Htra1 ) . -
pubmed
RESULTS : Transcript analysis indicated that despite certain similarities ,
IVD cells exhibit distinct
COL2A1 /
COL1A1 and
COL2A1 /
AGC1 ratios as compared with AC . -
pubmed
The expression pattern of
COL5A1 ,
MGP and
Htra1 makes it possible to define a phenotypic signature for
NP and
AF cells . -
pubmed
Type V collagen ,
MGP and
HtrA1 could greatly help to discriminate among NP ,
AF and
AC cells . -
pubmed
Cellular
FLICE - inhibitory protein (
c - FLIP ) signalling : a key regulator of receptor - mediated apoptosis in physiologic context and in
cancer . -
pubmed
The present review summarizes recent findings concerning
c - FLIP proteins ' function and regulation , with a main focus on the
c - FLIP ( L ) deregulated expression in
cancer . -
pubmed
The role of
c - FLIP ( L ) as anti - apoptotic pro - survival factor in
tumors and the potential utility of this molecule as a possible alternative therapeutic target are discussed . -
pubmed
Dysregulation of the
receptor activator of NF - kappaB ligand and
osteoprotegerin production influence the apoptosis of
multiple myeloma patients ' bone marrow stromal cells co - cultured with
myeloma cells . -
pubmed
Differences in
receptor activator of NF - kappaB ligand (
RANKL ) and
osteoprotegerin (
OPG ) production in BMSCs derived from
MM patients and control subjects and the apoptosis of BMSCs and
MM cells in co - cultures of both cell types were examined . -
pubmed
Production of soluble
RANKL was enhanced and the increase was more significant in the BMSCs of the
MM patients than in those of the controls . -
pubmed
Disturbances in the
RANKL /
OPG system are more profound in the BMSCs of
MM patients than in those of control subjects after direct contact with
RPMI8226 cells . -
pubmed
Breaking T cell tolerance against self
type II collagen in
HLA - DR4 - transgenic
mice and development of
autoimmune arthritis . -
pubmed
OBJECTIVE : To establish a new
animal model in
DRB1 * 0401 ( DR4)-transgenic
mice in which T cell tolerance to self
type II collagen (
CII ) can be broken and allow for the development of
autoimmune arthritis , to investigate the role of posttranslational modifications of the CII(259 - 273 ) epitope in the induction and breaking of tolerance of DR4 - restricted T cells , and to characterize
DR4 - restricted T cell recognition of the immunodominant CII(259 - 273 ) epitope . -
pubmed
METHODS :
DR4 - transgenic
mice expressing either the entire
human CII protein (
HuCII ) or only the immunodominant T cell epitope of heterologous
CII ( MMC ) in joint cartilage were established on different genetic backgrounds , and susceptibility to collagen - induced
arthritis (
CIA ) was tested . -
pubmed
CONCLUSION : It is possible to break tolerance to self
CII and induce
arthritis in DR4
mice . -
pubmed
However ,
arthritis susceptibility is tightly controlled by the genetic background and by the source of the transgenic element for expressing the heterologous CII peptide as a self
CII protein in the joint . -
pubmed
In contrast to
CIA in A(q)-expressing
mice , the nonglycosylated
CII(259 - 273 ) epitope is clearly immunodominant in both tolerized and nontolerized DR4
mice . -
pubmed
This feature led to the clinical development of
BoNT - A for a number of
neuromuscular disorders . -
pubmed
This review explores the mechanistic basis of this analgesic effect , summarizing current knowledge of the structure - function relationship of
BoNT and discussing effects on both motor and
pain neurons . -
pubmed
For a complete picture of the analgesic properties of
BoNT - A , clinical evidence of efficacy in
myofascial pain and
neuropathic pain is considered in tandem with a mechanistic rationale for activity . -
pubmed
Patients experiencing
chronic pain are clear candidates for treatment with a modified
clostridial endopeptidase that would provide enduring inhibition of neurotransmitter release . -
pubmed
Regulation of
Skp2 expression and activity and its role in
cancer progression . -
pubmed
Overexpression of
Skp2 is associated with a variety of
human cancers , indicating that
Skp2 may contribute to the development of
human cancers . -
pubmed
The notion is supported by various genetic
mouse models that demonstrate an oncogenic activity of
Skp2 and its requirement in
cancer progression , suggesting that
Skp2 may be a novel and attractive therapeutic target for
cancers . -
pubmed
Tumor suppressor
Pdcd4 is a major transcript that is upregulated during in vivo pancreatic islet neogenesis and is expressed in both beta - cell and ductal cell lines . -
pubmed
The coordinated increased expression of
biliverdin reductase and
heme oxygenase-2 promotes cardiomyocyte survival : a
reductase - based peptide counters
beta - adrenergic receptor ligand - mediated
cardiac dysfunction . -
pubmed
This is the first reporting of regulation of
HO-2 by
BVR and that their coordinated increase in isolated myocytes and intact heart protects against
cardiotoxicity of
beta - adrenergic receptor activation by
isoproterenol (
ISO ) . -
pubmed
Finding that
BVR and
HO-2 levels , myocyte apoptosis , and contractile function of the heart can be modulated by small
human BVR - based peptides offers a promising therapeutic approach for treatment of
cardiac dysfunctions . -
pubmed
Here , we show that
epidermal growth factor (
EGF ) induces
Toca-1 localization to lamellipodia , where it co - localizes with
F - actin and
Arp2 / 3 complex in
A431 epidermoid carcinoma cells . -
pubmed
Lactate dehydrogenase (
LDH ) release assay was used to evaluate NK cell
cytotoxicity . -
pubmed
The inhibitory effect of
ACh on NK cell
cytotoxicity was mimicked by
pilocarpine , an agonist of
muscarinic receptor , and by
nicotine , an agonist of
nicotinic receptor , at all applied concentrations ( 10(-10 ) - 10(-6 ) mol / L ) . -
pubmed
Muscarinic receptor antagonist
atropine blocked the inhibitory effect of
ACh on the
cytotoxicity of NK cells . -
pubmed
Nevertheless ,
tubocurarine , an antagonist of
nicotinic receptor , had no blocking effect on the suppression of NK cell
cytotoxicity by
ACh . -
pubmed
CONCLUSION :
ACh results in an inhibition of the
cytotoxicity of NK cells , and this inhibition is realized mainly through M and
N1 cholinergic receptor . -
pubmed
Control of
NF - kappaB and
inflammation by the unfolded protein response . -
pubmed
This review summarizes current knowledge on potential mechanisms underlying the biphasic , bidirectional regulation of
NF - kappaB by the UPR and possible roles for ER stress in the regulation of
inflammation . -
pubmed
The protective effect may be mediated through its regulation of apoptosis and activities of
T - AOC and
ChAT in the hippocampus and cortex of the
rats in the chronic
cerebral hypoperfusion model , a mechanism that is different from
rivastigmine . -
pubmed
The metastasis suppressor ,
N - myc downstream regulated gene-1 (
NDRG1 ) , has been shown to markedly reduce metastasis of numerous
tumors . -
pubmed
This effect was observed in three different
cancer cell types , including
PC3MM and
DU145 prostate cancer cells and
H1299 lung carcinoma cells , and occurred independently of
p53 . -
pubmed
Examining the mechanisms behind the effect of
NDRG1 on
p21 expression , we found that
NDRG1 upregulated
p21 via transcriptional and posttranscriptional mechanisms in
prostate cancer cells , although its effect on
H1299 cells was posttranscriptional only . -
pubmed
Additional functional studies identified that
NDRG1 inhibits
cancer cell migration , suggesting that
p21 is a molecular player in its antimetastatic activity . -
pubmed
Poly ( ADP - ribose ) polymerase-1 : a novel therapeutic target in
necrotizing enterocolitis . -
pubmed
Here , we tested the hypothesis that
NO dysregulation in intestinal epithelial cells during
NEC leads to marked
PARP-1 expression and that administration of a
PARP-1 inhibitor (
nicotinamide ) attenuates
intestinal injury in a newborn
rat model of
NEC . -
pubmed
We speculate that
PARP-1 overactivation in
NEC may drive mucosal cell death in this disease and that
PARP-1 may be a novel therapeutic target in
NEC . -
pubmed
Biology of
Cox-2 : an application in
cancer therapeutics . -
pubmed
Molecular pathology studies have revealed that
Cox-2 is over - expressed in
cancer and stroma cells during
tumor progression , and anti - cancer chemo - radiotherapies induce expression of
Cox-2 in
cancer cells . -
pubmed
Elevated
tumor Cox-2 is associated with increased angiogenesis ,
tumor invasion and promotion of
tumor cell resistance to apoptosis . -
pubmed
Much attention is being focused on
Cox-2 inhibitors as beneficial target for
cancer chemotherapy . -
pubmed
Further clinical application needs to be investigated for comprehending
Cox-2 biological functions and establishing it as an effective target in
cancer therapy . -
pubmed
A proteomics platform combining depletion , multi -
lectin affinity chromatography ( M - LAC ) , and isoelectric focusing to study the
breast cancer proteome . -
pubmed
In addition , potential glycan changes were indicated by comparing proteins in control and
cancer samples in terms of their affinity to the multi -
lectin column ( M - LAC ) and the pI profiles in IEF separation . -
pubmed
In conclusion , a proteomics platform including high abundance protein depletion ,
lectin affinity fractionation , IEF separation , and LC - MS analysis has been applied to discover
breast cancer - associated proteins . -
pubmed
Asymmetric cell shapes in the
DM epithelium are hypothesized to contribute to the tilt , however , it is unclear what lies downstream of
Pitx2 to alter epithelial cell shape . -
pubmed
The cells of the left
DM epithelium in either
Pitx2 or
Shroom3 deficient embryos are shorter and wider than those in control embryos and resemble the shape of those on the right , demonstrating that like
Pitx2 ,
Shroom3 is required for cell shape asymmetry and the leftward DM tilt . -
pubmed
Because
N - cadherin expression is specific to the left side and is
Pitx2 dependent , we determined whether
Shroom3 and
N - cadherin function together to regulate cell shape in the left
DM epithelium . -
pubmed
Analysis of
mouse embryos lacking one allele of both
Shroom3 and
N - cadherin revealed that they possess shorter and wider left epithelial
DM cells when compared with
Shroom3 or
N - cadherin heterozygous embryos . -
pubmed
EBV -
LMP1 staining was demonstrated in 41/57 ( 71 % ) of the mixed cellularity and the 19/35 ( 54.2 % ) of
nodular sclerosis subtypes . -
pubmed
Radiofrequency - assisted liver resection was associated with diminished
blood loss ( P & lt ; 0.0001 ) , a lower blood transfusion rate ( P & lt ; 0.005 ) , reduced operative time ( P & lt ; 0.0001 ) , and better postoperative
serum albumin levels ( P & lt ; 0.03 ) . -
pubmed
Overexpression of the
human epidermal growth factor receptor 2 (
HER2 ) predicts a poor prognosis in metastatic
breast cancer . -
pubmed
While the introduction of
HER2 - targeted therapies , such as the monoclonal antibody trastuzumab and the small - molecule
tyrosine kinase inhibitor
lapatinib , has significantly improved outcomes in
HER2 +
breast cancer compared with previously available therapies , use of these targeted therapies is often limited by the development of drug resistance and tolerability issues . -
pubmed
Recently , several agents have demonstrated promising activity in
HER2 + metastatic
breast cancer , either as monotherapy or in combination therapy , including the
tyrosine - kinase inhibitors
neratinib (
HKI-272 ) and
afatinib (
BIBW-2992 ) and the anti -
HER2 monoclonal antibodies pertuzumab and trastuzumab - DM1 ( T - DM1 ) . -
pubmed
Agents that target other molecular pathways , such as the
vascular endothelial growth factor receptor ,
mammalian target of rapamycin ,
PI3 - kinases ,
insulin - like growth factor (
IGFR ) ,
HSP-90 , and other
kinases also have potential , in combination with anti -
HER2 and/or other systemic therapies , to be active in this subtype of
breast cancer . -
pubmed
Association between hippocampal volume and serum
adiponectin in
patients with
type 2 diabetes mellitus . -
pubmed
The aim of the present study was to test the hypothesis that the level of the adipocytokine
adiponectin correlates with hippocampus volume and
insulin resistance in
patients with
type 2 DM . -
pubmed
A total of 45
patients with
type 2 DM were divided into two groups : a low
adiponectin group and a normal
adiponectin group . -
pubmed
These results suggest that circulating levels of
adiponectin are related to hippocampus volume in
patients with
type 2 DM . -
pubmed
Disruption of
delta - opioid receptor phosphorylation at
threonine 161 attenuates
morphine tolerance in
rats with CFA - induced
inflammatory hypersensitivity . -
pubmed
The aim of this study was to assess the function of
DOR phosphorylation by
Cdk5 in complete Freund 's adjuvant ( CFA)-induced inflammatory
pain and
morphine tolerance . -
pubmed
METHODS : Dorsal root ganglion ( DRG ) neurons of
rats with CFA - induced
inflammatory pain were acutely dissociated and the biotinylation method was used to explore the membrane localization of phosphorylated
DOR at
Thr-161 (
pThr-161 - DOR ) , and paw withdrawal latency was measured after intrathecal delivery of drugs or
Tat - peptide , using a radiant heat stimulator in
rats with CFA - induced
inflammatory pain . -
pubmed
Intrathecal delivery of the engineered
Tat fusion - interefering peptide corresponding to the second intracellular loop of
DOR (
Tat - DOR-2L ) increased inflammatory
hypersensitivity , and inhibited
DOR- but not micro - opioid receptor - mediated spinal analgesia in CFA - treated
rats . -
pubmed
However , intrathecal delivery of
Tat -
DOR-2L postponed
morphine antinociceptive tolerance in
rats with CFA - induced
inflammatory pain . -
pubmed
CONCLUSION : Phosphorylation of
DOR at
Thr-161 by
Cdk5 attenuates
hypersensitivity and potentiates
morphine tolerance in
rats with CFA - induced
inflammatory pain , while disruption of the phosphorylation of
DOR at
Thr-161 attenuates
morphine tolerance . -
pubmed
Viral diversity and diversification of major non - structural genes
vif ,
vpr ,
vpu ,
tat exon 1 and rev exon 1 during primary
HIV-1 subtype C infection . -
pubmed
The mean intra - patient diversity was 0.11 % ( 95 % CI ; 0.02 to 0.20 ) for
vif , 0.23 % ( 95 % CI ; 0.08 to 0.38 ) for
vpr , 0.35 % ( 95 % CI ; -0.05 to 0.75 ) for
vpu , 0.18 % ( 95 % CI ; 0.01 to 0.35 ) for tat exon 1 and 0.30 % ( 95 % CI ; 0.02 to 0.58 ) for rev exon 1 during the time period 0 to 90 days p / s. The intra - patient diversity increased gradually in all non - structural genes over the first year of
HIV-1 infection , which was evident from the vif mean intra - patient diversity of 0.46 % ( 95 % CI ; 0.28 to 0.64 ) , vpr 0.44 % ( 95 % CI ; 0.24 to 0.64 ) ,
vpu 0.84 % ( 95 % CI ; 0.55 to 1.13 ) , tat exon 1 0.35 % ( 95 % CI ; 0.14 to 0.56 ) and rev exon 1 0.42 % ( 95 % CI ; 0.18 to 0.66 ) during the time period of 181 to 500 days p / s. There was a statistically significant increase in viral diversity for
vif ( p = 0.013 ) and
vpu ( p = 0.002 ) . -
pubmed
The experimental
ICH was induced by intrastriatal administration of
bacterial collagenase IV in adult
rats . -
pubmed
We used three
mouse models of pathological ocular neovascularization :
oxygen - induced
retinopathy ( a
mouse model of
ischemic retinopathies ) , laser - induced
choroidal neovascularization , and a
human VEGF transgenic
mouse that overexpresses
human VEGF specifically in photoreceptor cells and generates pathological neovascularization in the retina . -
pubmed
Over - expression of
PUMA correlates with the apoptosis of spinal cord cells in
rat neuropathic intermittent claudication model . -
pubmed
Compared to those without
hearing impairment ,
patients with
hearing impairment had lower serum
ferritin levels ( P = 0.01 ) . -
pubmed
Lower
serum ferritin levels may be associated with
hearing impairment . -
pubmed
Effectiveness and safety of
rabbit anti - thymocyte globulin in Japanese
patients with
aplastic anemia . -
pubmed
RESULTS : In the
psoriatic patients without
arthritis , serum
25 -( OH ) D levels were inversely correlated with fasting
glucose ( r = -0.285 ; P = .026 ) , total
cholesterol ( r = -0.440 ; P = .000 ) ,
low - density lipoprotein ( r = -0.415 ; P = .001 ) , total
cholesterol /
high - density lipoprotein ( r = -0.303 ; P = .01 ) , and
triglyceride ( r = -0.280 ; P = .029 ) values . -
pubmed
Clinicopathological and molecular significance of Sumolyation marker (
ubiquitin conjugating enzyme 9 (
UBC9 ) ) expression in
breast cancer of black women . -
pubmed
In contrast to the well - defined predictive factors for the hormonal therapy , there is a paucity of information on the
BRCA1 deficiency breast
tumor biology , particularly among African women . -
pubmed
BRCA1 Sumoylation (
UBC9 ) has been speculated to be involved in the
ER transcription activity ,
BRCA1 deficiency and triple negative
BC . -
pubmed
We therefore hypothesized that
UBC9 , a SUMOylation marker , may have contributed to the aggressive nature of
BRCA1 tumor phenotype observed in Nigerian women . -
pubmed
The protein expression of
UBC9 , as compared with other biomarkers , showed an inverse correlation with
steroid hormones (
ER ,
progesterone ( PgR ) ) ,
BRCA1 ,
p27 ,
p21 and
MDM4 , and a positive correlation with triple negative , basal
cytokeratins (
CK14 and
CK5 / 6 ) ,
epidermal growth factor receptor (
EGFR ) , basal - like
breast cancer phenotype ,
p53 ,
phosphoinositide-3 - kinases (
PI3KCA ) ,
placental cadherin , (
P - cadherin ) and
BRCA1 regulators (
metastasis tumor antigen-1 (
MTA1 ) . -
pubmed
Survival analysis showed that those
tumors positive for
UBC9 expression had a significantly poorer
breast cancer - specific survival ( BCSS ) as compared with those showing negative expression . -
pubmed
This study demonstrates that
UBC9 appears to play an important role in the
tumor biology of Nigerian women . -
pubmed
Therefore , a novel
UBC9 targeted therapy in black women with
BC could enhance a better
patient outcome . -
pubmed
Imaging studies on
dopamine transporter and
depression : a review of literature and suggestions for future research . -
pubmed
We review the conflicting results from imaging studies of
dopamine transporter availability in
depressed patients and also discuss the heterogeneity of the variables involved . -
pubmed
The
ESRD patients who underwent hemodialysis had a different flora and showed slightly higher levels of hs -
CRP ,
IL-6 , and
plasma endotoxin , compared with those in
ESRD patients who did not undergo hemodialysis . -
pubmed
Evaluation of nonsurgical periodontal therapy in
chronic periodontitis patients with
anemia by estimating hematological parameters and high - sensitivity
C - reactive protein levels . -
pubmed
Certain inflammatory
cytokines produced during
periodontal inflammation increase the production of acute phase proteins like high - sensitivity
C - reactive protein (
hs - CRP ) and can depress
erythropoietin production leading to the development of
anemia . -
pubmed
AIM : The aim of this study is to investigate the efficacy of nonsurgical periodontal therapy on red blood cell ( RBC ) parameters and hs -
CRP in
chronic periodontitis patients with
anemia . -
pubmed
A total of 30
subjects with
anemia and
chronic periodontitis with age group of 33 - 55 years were selected by screening
hemoglobin (
Hb ) levels and examining periodontal findings . -
pubmed
There is significant decrease in levels of
ESR and hs -
CRP levels after nonsurgical periodontal therapy indicating resolution of
periodontal inflammation . -
pubmed
Minimal changes in mean corpuscular volume , mean
corpuscular hemoglobin (
MCH ) and
MCH concentration indicated that the lower values of red cell parameters are not due to any vitamin and mineral deficiencies , but secondary to the chronic inflammatory changes associated with chronic
periodontal disease . -
pubmed
CONCLUSION : The present study strengthens the hypothesis that chronic
periodontitis may lead to
anemia and provides evidence that nonsurgical periodontal therapy can improve the anemic status and reduce levels of
hs - CRP in
patients with
chronic periodontitis . -
pubmed
Metallothionein (
MT ) gene therapy leads to resolution of
liver fibrosis in
mouse model , in which the activation of
collagenases is involved in the regression of
liver fibrosis . -
pubmed
Male
Kunming mice subjected to bile duct ligation ( BDL ) resulted in
liver fibrosis as assessed by increased
alpha - smooth muscle actin (
alpha - SMA ) and
collagen I production / deposition in the liver . -
pubmed
Therefore , the results demonstrate that
zinc supplementation suppresses BDL - induced
liver fibrosis through both inhibiting
collagen production and enhancing
collagen degradation . -
pubmed
Compared with ACSF - exposed animals ,
SCI - elevated [
H2O2 ] significantly increased intracellular protein and DNA oxidation by threefold and
MLP by eightfold in neurons , respectively . -
pubmed
Therefore , we conclude that ( 1 ) the role of
H2O2 in secondary
SCI is pro - oxidation and pro - cell death , ( 2 ) apoptosis is a pathway for
SCI - elevated [
H2O2 ] to induce cell death , ( 3 )
caspase activation is a mechanism of
H2O2 - induced apoptosis after
SCI , and ( 4 )
MnTBAP treatment significantly decreased
H2O2 - induced oxidation , cell loss , and apoptosis to the levels of ACSF controls , further supporting
MnTBAP 's ability to scavenge
H2O2 by in vivo evidence . -
pubmed
Indeed , such treatment causes a behavioural supersensitivity to
dopamine D2 receptor agonists associated with an increase sexual activity and
aggressivity (
mania ) . -
pubmed
The
dopamine receptor sensitization is followed , after
imipramine discontinuation , by an opposite phenomenon (
dopamine receptor desensitization ) and an increased immobility time (
depression ) in the forced swimming test of
depression . -
pubmed
LECs secrete pro - inflammatory
cytokines and
chemokines to create local inflammatory conditions for recruitment of naive antigen presenting cells ( APCs ) such as dendritic cells ( DCs ) to sites of
infection and/or vaccine administration . -
pubmed
The confirmed prevalence of
hypersensitivity to Hymenoptera stings according to skin tests and in vitro
sIgE levels was 0.2 % ( 95 % CI : 0.14 - 0.30 % ) . -
pubmed
Tailored anti -
TNF therapy during pregnancy in
patients with
IBD : maternal and fetal safety . -
pubmed
OBJECTIVE :
Antitumour necrosis factor (
TNF ) during pregnancy in
patients with
IBD is related to high fetal anti -
TNF levels . -
pubmed
DESIGN : Two groups of
women with
IBD were prospectively followed - up during pregnancy :
women in sustained remission stopped anti -
TNF before week 25 ( stop group ) and the remaining group continued anti -
TNF beyond week 30 ( continue group ) . -
pubmed
Growth ,
infection rate ,
allergies ,
eczema and adverse reactions to vaccines were comparable across the stop and the continue groups as well as the
children of anti -
TNF - exposed and non - IBD women at 1 year . -
pubmed
CONCLUSIONS : To limit anti -
TNF exposure in utero , anti -
TNF can be stopped safely in the second trimester in
women with
IBD in sustained remission . -
pubmed
, 95%CI : 1.08 - 2.84 ) , high BP / low
HDL - C ( OR:1.68 , 95%CI : 1.05 - 2.60 ) and high WC / low
HDL - C ( OR : 2.41 , 95 % CI : 1.37 - 4.23 ) phenotypes were associated with adult
MetS. -
pubmed
Prognosis , stage and
oestrogen receptor status of contralateral
breast cancer in relation to characteristics of the first
tumour , prior endocrine treatment and radiotherapy . -
pubmed
An
ER - negative BC2 was associated with an inferior prognosis compared to an
ER - positive BC2 regardless of
ER - status of BC1 or prior endocrine therapy . -
pubmed
Role of
HMGB1 in regulation of
STAT3 expression in CD4(+ ) T cells from
patients with
aGVHD after allogeneic hematopoietic stem cell transplantation . -
pubmed
HMGB1 is a
cytokine mediator of
inflammation and an important chromatin protein regulating gene transcription . -
pubmed
In this study , we found that the expressions of
HMGB1 and
STAT3 were higher in
CD4(+ ) T cells of
patients with
aGVHD compared with those without
aGVHD , and the
HMGB1 expression was positively correlated with the
STAT3 expression . -
pubmed
We also demonstrated that
HMGB1 could regulate the expression of
STAT3 by modulation of its DNA methylation in CD4(+ ) T cells , moreover downregulated
HMGB1 in
aGVHD CD4(+ ) T cells could change the ratio of Treg / Th17 . -
pubmed
These data strongly suggest that
HMGB1 plays a crucial role in the regulation of Treg / Th17 and progression of
aGVHD . -
pubmed
BACKGROUND : Early treatment for
Crohn ' s disease (
CD ) with immunomodulators and/or anti -
TNF agents improves outcomes in comparison to a slower ' step up ' algorithm . -
pubmed
Significant variables in the multivariate Cox model included
small bowel disease ( HR 2.12 , CI 1.05 - 4.29 ) , left
colonic disease ( HR 0.73 , CI 0.49 - 1.09 ) ,
perianal disease ( HR 4.12 , CI 1.01 - 16.88 ) , ASCA ( HR 1.35 , CI 1.16 - 1.58 ) , Cbir ( HR 1.29 , CI 1.07 - 1.55 ) , ANCA ( HR 0.77 , CI 0.62 - 0.95 ) , and the
NOD2 frameshift mutation / SNP13 ( HR 2.13 , CI 1.33 - 3.40 ) . -
pubmed
Host control of
influenza A virus (
IAV ) is associated with exuberant
pulmonary inflammation characterized by the influx of myeloid cells and production of
proinflammatory cytokines including
interferons (
IFNs ) . -
pubmed
Here , we demonstrate that in addition to its known anti - viral activity ,
STAT1 signaling coordinates host inflammation during
IAV infection in
mice . -
pubmed
Polydatin Protecting Kidneys against
Hemorrhagic Shock - Induced
Mitochondrial Dysfunction via
SIRT1 Activation and
p53 Deacetylation . -
pubmed
CONCLUSIONS : MD is present in severe
HS , and PD can attenuate MD of RTECs via the
SIRT1 -
p53 pathway . -
pubmed
Maternal Embryonic Leucine Zipper Kinase (
MELK ) as a Novel Mediator and Biomarker of Radioresistance in
Human Breast Cancer . -
pubmed
PURPOSE : While effective targeted therapies exist for
estrogen receptor - positive and
HER2 - positive breast cancer , no such effective therapies exist for triple - negative
breast cancer (
TNBC ) ; thus , it is clear that additional targets for radiosensitization and treatment are critically needed . -
pubmed
RESULTS :
MELK expression is significantly elevated in
breast cancer tissues compared with
normal tissue as well as in
TNBC compared with
non - TNBC . -
pubmed
MELK RNA and protein expression is significantly correlated with radioresistance in
breast cancer cell lines . -
pubmed
Inhibition of
MELK ( genetically and pharmacologically ) induces radiation sensitivity in vitro and significantly delayed
tumor growth in vivo in multiple models . -
pubmed
CONCLUSIONS : Here , we identify
MELK as a potential biomarker of radioresistance and target for radiosensitization in
TNBC . -
pubmed
Our results support the rationale for developing clinical strategies to inhibit
MELK as a novel target in
TNBC . -
pubmed
Isoliquiritigenin suppresses
tumor necrosis factor - alpha - induced
inflammation via
peroxisome proliferator - activated receptor - gamma in intestinal epithelial cells . -
pubmed
Intestinal epithelial cells play an important role in the mucosal immune reaction in
inflammatory bowel diseases via the expression of inflammatory mediators , such as
cyclooxygenase-2 (
COX-2 ) and
intercellular adhesion molecule-1 (
ICAM-1 ) . -
pubmed
Collectively ,
ISL - induced
PPARgamma mediated , at least partially , the suppression of intestinal
inflammation . -
pubmed
EPHA7 and
EPHA10 Physically Interact and Differentially Co - localize in
Normal Breast and Breast
Carcinoma Cell Lines , and the Co - localization Pattern Is Altered in
EPHB6 - expressing
MDA - MB-231 Cells . -
pubmed
SYP-5 , a novel
HIF-1 inhibitor , suppresses
tumor cells invasion and angiogenesis . -
pubmed
The overexpression of
HIF-1 induced by
hypoxia is closely associated with metastasis , poor prognosis and high mortality . -
pubmed
Western blots results showed
SYP-5 inhibited
hypoxia - induced upregulation of
HIF-1 . -
pubmed
Furthermore , in the tube formation assay ,
SYP-5 suppressed angiogenesis induced by
hypoxia and
VEGF in vitro . -
pubmed
Additionally , using Transwell and RTCA assays , we found that
SYP-5 also retarded the
Hep3B and
Bcap37 cells migration and invasion induced by
hypoxia and FBS . -
pubmed
These results indicates that
SYP-5 inhibits
tumor cell migration and invasion , as well as
tumor angiogenesis , which are mediated by suppressing
PI3K /
AKT- and
MAPK /
ERK - dependent
HIF-1 pathway . -
pubmed
The role of common protective alleles
HLA - DRB1 * 13 among systemic
autoimmune diseases . -
pubmed
Associations between
human leukocyte antigen (
HLA ) and susceptibility to systemic
autoimmune diseases have been reported . -
pubmed
On the other hand , some
HLA alleles are associated with resistance to systemic
autoimmune diseases , including
systemic sclerosis ,
systemic lupus erythematosus and
rheumatoid arthritis . -
pubmed
Interestingly ,
DRB1 * 13 alleles are the protective alleles shared by multiple
autoimmune diseases . -
pubmed
Thus far , association studies suggested that
DRB1 * 13:02 represents at least one of the causally associated protective factors against multiple systemic
autoimmune diseases in the Japanese population . -
pubmed
DRB1 * 13:02 also confers protection against organ - specific
autoimmune diseases and some
infectious diseases . -
pubmed
Understanding of the protective mechanisms of
DRB1 * 13 may lead to the identification of targets for the curative treatment of systemic
autoimmune diseases . -
pubmed
Analyzing the Effect of V66 M Mutation in
BDNF in Causing
Mood Disorders : A Computational Approach . -
pubmed
A number of preclinical studies emphasize the essential role of
brain - derived neurotrophic factor (
BDNF ) in the pathophysiology of
mood disorders . -
pubmed
IL-33 is associated with a variety of
autoimmune diseases , such as
sclerosis ,
inflammatory bowel disease , and
rheumatoid arthritis . -
pubmed
In this study , we investigated the effects of
IL-33 on DC - mediated
CD4 + T cell activation and Th17 cell differentiation because DCs are essential cells for presenting self - antigens to CD4 + T cells in
autoimmune disease conditions . -
pubmed
WWC3 : the bridge linking
Hippo and
Wnt pathways in
lung cancer . -
pubmed
When additionally adjusting for total- ,
LDL- and
HDL -
cholesterol ,
triglycerides and
C - reactive protein ,
acyl - alkyl - phosphatidylcholine C36:3 and
diacyl - phosphatidylcholines C38:3 and C40:4 remained associated with risk of
MI . -
pubmed
Therefore , we investigated the roles of
AT2R in FGR - induced
cardiovascular disease using
AT2R knockout ( AT2KO )
mice . -
pubmed
AT2R signaling may be involved in
cardiovascular disorders of adult offspring with
FGR . -
pubmed
Regulation of
AT2R could contribute to preventing future
cardiovascular disease in
FGR offspring . -
pubmed
SERUM LEVELS OF
ENDOTHELIAL MONOCYTE ACTIVATING PEPTIDE II IN
TYPE 1 DIABETES . -
pubmed
Was investigated serum level of
endothelial monocyte activating peptide II (
EMAP - II ) and endothelium - dependent dilatation in
type 1 diabetes and possible relation between those . -
pubmed
We found an increase serum level of
EMAP - II and decrease of endothelium - dependent dilatation in
type 1 diabetes . -
pubmed
The revealed change of
EMAP - II serum level reflects an endothelial dysfunction in
type 1 diabetes , alteration of
carbohydrate and lipid metabolism could influence of this pathway . -
pubmed
Tim-3 exacerbates
kidney ischaemia /
reperfusion injury through the
TLR-4 /
NF - kappaB signalling pathway and an NLR - C4 inflammasome activation . -
pubmed
In an established
murine model of
kidney IRI , we found that
Tim-3 expression is enhanced on monocytes / macrophages . -
pubmed
Anti -
Tim-3 antibody
RMT3 - 23 ameliorates biochemical and histological
kidney injury , reduces apoptosis and decreases macrophage infiltration and
cytokine production in ischaemic kidneys . -
pubmed
Taken together , our data confirm that
Tim-3 signalling enhances
injury after kidney IRI and demonstrated that
Tim-3 is involved in regulating
TLR-4 /
NF - kappaB signalling and
NLR - C4 inflammasome activation , which provide evidence that
Tim-3 signalling is critical for kidney IRI and may provide a new means to ameliorate kidney tissue immune responses in the clinics . -
pubmed
Nrf2 as a therapeutic target for
rheumatic diseases . -
pubmed
Therefore , the appropriate expression and balance of
Nrf2 is necessary for regulation of oxidative stress ,
inflammation , immune responses , and cartilage and bone metabolism . -
pubmed
In recent years , novel strategies have been sought to modulate the
Nrf2 pathway which has emerged as a therapeutic target in
rheumatic conditions . -
pubmed
Methods : Circulating EPCs were identified as
CD34+
CD133+
CD31 + cells by flow cytometer in
ALC patients ( n = 7 ) and healthy controls ( HC , n = 7 ) . -
pubmed
Ex vivo cultures of circulating EPCs from
ALC patients ( n = 20 ) and controls ( n = 18 ) were also tested for their functions , including colony formation ,
LDL uptake ,
lectin binding and
cytokine secretion ( ELISA ) . -
pubmed
Increase in CD45hi EPC subtype in
ALC patients with enhanced functions ,
inflammatory cytokines and angiogenic mediators in
patients suggests an inflammatory role for these cells in
ALC . -
pubmed
MicroRNA-28 - 5p inhibits the migration and invasion of
gastric cancer cells by suppressing
AKT phosphorylation . -
pubmed
In conclusion , miR-28 - 5p is a tumor suppressor that inhibits
gastric cancer cell migration and invasion through repressing
AKT phosphorylation . -
pubmed
Activation of
trace amine - associated receptor 1 attenuates schedule - induced
polydipsia in
rats . -
pubmed
The present study appears to be the first that estimated the action of
TAAR1 agonists on schedule - induced
polydipsia , a type of adjunctive behavior , which is considered to be useful for evaluating certain aspects of
obsessive - compulsive and related disorders (
OCD ) and
schizophrenia . -
pubmed
Our results have demonstrated that the wide range of
RO5263397 , the highly selective partial
TAAR1 agonist , doses ( 1 - 10 mg / kg ) attenuated the
polydipsia induced by two different schedules of food delivery in
rats . -
pubmed
Alterations in
KMT2D ,
CREBBP , or
ARID1A or in DNA damage response and repair genes were present at a significantly higher frequency in
LS -
UTUC . -
pubmed
CIC ,
NOTCH1 ,
NOTCH3 ,
RB1 , and
CDKN1B alterations were almost exclusive to
LS -
UTUC . -
pubmed
Although
FGFR3 mutations were identified in both cohorts , the R248C hotspot mutation was highly enriched in
LS -
UTUC . -
pubmed
LS -
UTUC is associated with hypermutation and a significantly higher prevalence of
FGFR3 R248C mutation . -
pubmed
SP1 induced lncRNA
CASC11 accelerates the
glioma tumorigenesis through targeting
FOXK1 via sponging miR-498 . -
pubmed
In vivo and vitro , the knockdown of
CASC11 impaired the proliferation , migration and
tumor growth of
glioma cells . -
pubmed
Taken together , the data suggest the regulation of
SP1 /
CASC11 / miR-498 /
FOXK1 in the gliomagenesis , which might provide a potential therapeutic strategy for
glioma . -
pubmed
Alagille Syndrome : A Novel Mutation in
JAG1 Gene . -
pubmed
Alagille syndrome is an
autosomal dominant multisystem disorder with variable phenotypic penetrance , caused by heterozygous mutations in
JAG1 or
NOTCH2 , encoding for the components of the Notch signaling pathway . -
pubmed
Identification of
Aloperine as an anti - apoptotic
Bcl2 protein inhibitor in
glioma cells . -
pubmed
Moreover , western blot and qPCR analysis showed that
ALO downregulated
Bcl2 expression in
human glioma cell lines ,
SK - N - AS and
U118 . -
pubmed
In addition ,
Bcl-2 overexpression could rescue
ALO - induced
Bcl-2 inhibition and suppress pro - apoptotic effects in
glioma cells . -
pubmed
Conclusion : Taken together , these findings suggest that the natural agent
ALO effectively enhances apoptosis by acting as a potential
Bcl2 inhibitor in
human glioma cells . -
pubmed
The therapeutic potential of
PPARs antagonists extends beyond
diabetes . -
pubmed
PPARs antagonists represent a new drug class that holds promise as a broadly applicable therapeutic approach for
cancer treatment . -
pubmed
Di ( 2 - ethylhexyl ) phthalate inhibits
glutathione regeneration and
dehydrogenases of the
pentose phosphate pathway on
human colon carcinoma cells . -
pubmed
OBJECTIVE : Combined
methylmalonic acidemia and
homocysteinemia is a genetically heterogeneous disorder of
cobalamin (
cbl ;
vitamin B12 ) metabolism , which consists of five subtypes including cblC ,
cblD ,
cblF ,
cblJ , and
cblX deficiencies . -
pubmed
Moreover , all patients carried compound heterozygous mutations ( c.80A > G , c.609G > A ) in
MMACHC and improved significantly after being treated for
cblC deficiency and
PAH . -
pubmed
In angiogenesis , the expression of
CD31 showed a higher percentage of blood vessels in
OSCC ( p < 0.001 ) , however ,
CD34 showed no difference between groups ( p=0.092 ) . -
pubmed
OBJECTIVE :
Acromegaly is characterized by high neoplastic morbidity as a side effect of
growth hormone ( GH ) hypersecretion . -
pubmed
Circ -
RPL15 / miR-146b-3p /
VEGFA feedback loop is responsible for triggering proliferation and migration in
glioma . -
pubmed
OBJECTIVE : This study aims to elucidate the role of circ -
RPL15 in the progression of
glioma . -
pubmed
PATIENTS AND METHODS :
Circ -
RPL15 levels in
glioma tissues and normal brain tissues were detected . -
pubmed
RESULTS :
Circ -
RPL15 and
VEGFA were upregulated in
glioma tissues than normal ones , whereas miR-146b-3p was downregulated . -
pubmed
The interaction in the circ -
RPL15 / miR-146b-3p /
VEGFA feedback loop was indicated by Luciferase assay , and it markedly promoted proliferative and migratory abilities in
glioma . -
pubmed
CONCLUSIONS :
Circ -
RPL15 triggers proliferative and migratory potentials in
glioma by competitively binding miR-146b-3p and thus upregulates
VEGFA . -
pubmed
Although , these results may be explained partly by the plasma hyperosmolarity and
hypernatremia observed in
MnPO - lesioned
rats ; they also shed light on the role of the
MnPO in central neuronal control of renal
sodium handling during chronic high dietary salt intake . -
pubmed
Estrogen Receptor Beta Inhibits the Proliferation , Migration , and Angiogenesis of
Gastric Cancer Cells Through Inhibiting
Nuclear Factor - Kappa B Signaling [ Retraction ] . -
pubmed
Identification of a novel homozygous variant in the
alkaline phosphate (
ALPL ) gene associated with
hypophosphatasia . -
pubmed
The lack of awareness of patient risk factors , failure to obtain adequate family history , was discussed by clinical experience in prenatal testing of
hypophosphatasia with a novel variant in the
ALPL gene identified in the index case of the family . -
pubmed
Merozoite Surface Protein 2 Adsorbed onto Acetalated Dextran Microparticles for
Malaria Vaccination . -
pubmed
Merozoite surface protein 2 (
MSP2 ) is a promising vaccine antigen as
MSP2 - specific antibodies have been shown previously to be protective against
malaria infection . -
pubmed
As such ,
MSP2 adsorbed to Ace -
DEX MPs demonstrates promise as a
malaria vaccine . -
pubmed
Loss of 20q13.13 is characteristic of
BIA - ALCL compared with other classes of
ALCL , such as primary
cutaneous ALCL and systemic type
ALK+ and
ALK - ALCL . -
pubmed
Although this is commonly observed across various types of
T - cell lymphomas , the extent of deregulation is significantly higher in
BIA - ALCL , as indicated by phosphorylated
STAT3 immunohistochemistry . -
pubmed
Additionally , co - supplementation significantly decreased fasting
glucose ( beta - 7.40 mg / dL ; 95 % CI , - 10.15 , - 4.64 ; P < 0.001 ) ,
insulin levels ( beta - 1.46 muIU / mL ; 95 % CI , - 2.35 , - 0.57 ; P = 0.002 ) , and homeostasis model of assessment -
insulin resistance ( beta - 0.51 ; 95 % CI , - 0.72 , - 0.29 ; P < 0.001 ) and a significant increase in quantitative
insulin sensitivity check index ( beta 0.01 ; 95 % CI , 0.006 , 0.01 ; P < 0.001 ) compared with the placebo . -
pubmed
sIg+ lymphocytes detected by immunofluorescence and by
51Cr release
cytotoxicity showed similar frequency and adherence properties . -
pubmed
Lymphocytes bearing
major histocompatibility complex ( MHC ) Ia - like antigens shown by eosin exclusion or 51Cr release
cytotoxicity were enriched in the adherent fraction , but also occurred in significant numbers in the non - adherent fraction . -
pubmed
[ Results of repeated
IgE titre determinations for the early diagnosis of
tumour recurrence in the otolaryngological area ( author 's transl ) ] . -
pubmed
Repeated serum
IgE determinations in 292
tumour patients , in parallel with clinical check - ups , show the great diagnostic significance of the serum
IgE level . -
pubmed
The
IgE titre variations give an insight into the
tumour - host relationship and , in particular , into the current state of activity of the
tumour patients who were found to be
tumour - free after specific therapy have constant serum
IgE values on repeated examination . -
pubmed
Tumour recurrence or metastases cause a sharp increase in the serum
IgE level already before clinical manifestations can be ascertained . -
pubmed
Intradermal sensitivity test prior to use of
streptokinase in
acute myocardial infarction . -
pubmed
In two of the five intraperitoneal - treated ducks , a reduction in the levels of duck
hepatitis B surface antigenaemia (
DHBsAg ) was observed . -
pubmed
on the therapeutic level : the attacks resist
barbiturate and
benzodiazepin treatment in 80 % of the cases , but the attacks diminish as the
diabetes is brought under control through
insulin treatment . -
pubmed
Decreased
salivary epidermal growth factor in
rheumatoid disease : a possible mechanism for increased susceptibility to
gastric ulceration . -
pubmed
We have used sequence information from complementary DNA clones , derived from the gene that is deleted in
DMD patients , to generate an antiserum that stains the surface membrane of intact
human and
mouse skeletal muscle , but not that of
DMD patients and
mdx mice . -
pubmed
Using computed tomography , lateral ventricular size was studied in a sample of 112 institutionalized
chronic schizophrenic patients ( selected from 510 cases to investigate the correlates of the defect state and
intellectual decline and the effects of
insulin , electroconvulsive and neuroleptic treatment ) , and compared with matched groups of non - institutionalized schizophrenics ,
patients with first
schizophrenic episodes , institutionalized and non - institutionalized
patients with
primary affective disorder , and
neurotic out -
patients . -
pubmed
Ventricular enlargement was unrelated to past physical treatment ( neuroleptics ,
insulin coma and electroconvulsive therapy ) . -
pubmed
[ Dosage and duration of the
streptokinase treatment in
myocardial infarct . -
pubmed
Incubation of peritoneal lymphocytes with
Corynebacterium parvum and
interferon in vitro did not result in augmented
cytotoxicity against susceptible targets . -
pubmed
Cytokines are known to play a major role in mediating many of the immunological and pathological features of
allergic disease . -
pubmed
Fifteen
patients were
hyperthyroid , and 16 were euthyroid but had inhibited secretion of
thyrotropin . -
pubmed
For
hyperthyroid patients , levels of thyroid hormones returned to normal in 69 % after one cycle and in 77 % after two cycles , and levels of
thyrotropin returned to normal in 38 % after one cycle and in 69 % after two cycles ; normal levels of
thyrotropin were achieved in 93 % of the euthyroid
patients after one cycle of treatment and in 100 % of these
patients after two cycles . -
pubmed
Induction of
proliferating cell nuclear antigen in
cervical human papilloma virus lesions . -
pubmed
The use of a
proton pump inhibitor - containing regimen offers the advantage of rapid symptom relief and the highest rates of
duodenal ulcer healing . -
pubmed
The aim of this study was to characterize the changes in the quantitative expression of
beta 2 - integrins and
L - selectin detected by means of
fluorochrome - conjugated monoclonal antibodies and flow cytometry on leukocytes in the systemic circulation after a major
musculoskeletal trauma , i.e. -
pubmed
Whole and parotid saliva
IgA ,
IgA1 and
IgA2 concentrations have been found to be lower in both
HIV infection and
AIDS subjects , whereas serum
IgA and
IgA subclasses are markedly raised , suggesting a dichotomy between systemic and secretory immunity . -
pubmed
Antibody responses to oral microbes have also been studied and it has been shown that
IgA ,
IgA1 and
IgA2 subclass antibody titres to
Candida albicans and to
Streptococcus mutans are increased in whole or parotid saliva from
HIV patients , but reduced in
AIDS patients , suggesting a compensatory response which is overcome with progressive
immunodeficiency . -
pubmed
The avidity of
salivary IgA antibodies to
Candida in
HIV seems unimpaired , whereas relative avidities of serum antibodies in
HIV patients with
candidiasis are lowered . -
pubmed
The candidacidal ,
myelomonocytic protein calprotectin is present in saliva at levels which are biologically active , although levels are lowered in
HIV infection . -
pubmed
Overall ,
HIV infection appears to be associated with disregulation of a number of
immune factors at the mucosal surface , but the ability of patients with
HIV infection to mount specific antibody secretory responses seems to be relatively intact until late in
infection . -
pubmed
Our studies revealed immunoreactivity of
IHBs with the monoclonal antibodies
SMI 31 and
MPM-2 , which recognize hyperphosphorylated epitopes present on paired helical filaments in
Alzheimer ' s disease brains ( SMI 31 ) or on diverse proteins hyperphosphorylated by
mitotic kinases in the M - phase of the cell cycle ( MPM-2 ) . -
pubmed
One- and two - dimensional gel electrophoresis of
tumor extracts followed by immunoblotting with
SMI 31 and
MPM-2 antibodies revealed a major immunoreactive protein with an apparent molecular weight between 62 and 65 kd , which was resolved into several highly acidic ( pH 4.5 ) protein components in two - dimensional gels . -
pubmed
IHBs observed in the
hepatocellular carcinoma cells presented are the first indications of a role of
p62 in disease . -
pubmed
The extent of
human sodium iodide symporter (
hNIS ) expression in different kinds of
human thyroid cancer tissues and cell lines remains controversial . -
pubmed
Results showed that 2 of 3
normal tissue , 3 of 6
nodular hyperplasia , one follicular
adenoma , 3 of 11
papillary thyroid carcinoma , 1 of 5 follicular
carcinoma and none of 3 metastatic thyroid epithelial tissue specimens stained positively for
hNIS . -
pubmed
In conclusion , although the number of tissue samples examined in this study was small ,
hNIS staining found a higher ratio of symporter protein expression in
normal and benign thyroid tissues compared with malignant tissues . -
pubmed
Elevated expression of
IL-3Ralpha in
acute myelogenous leukemia is associated with enhanced blast proliferation , increased cellularity , and poor prognosis . -
pubmed
We have investigated the expression of
interleukin-3 receptor alpha ( IL-3Ralpha ) chain in primary blasts from 79
patients with
acute myeloid leukemia (
AML ) , 25
patients with
B - acute lymphoid leukemia (
B - ALL ) , and 7
patients with
T - acute lymphoid leukemia (
T - ALL ) to evaluate a linkage between the expression of this receptor chain , blast proliferative status , and disease prognosis . -
pubmed
Although
IL-3Ralpha chain was scarcely expressed in most
patients with
T - ALL , it was overexpressed in 40 % and 45 % of
patients with
B - ALL and
AML , respectively , compared with the levels observed in normal CD34(+ ) progenitors . -
pubmed
Second , spontaneous
signal transducer and activator of transcription 5 (
Stat5 ) phosphorylation was observed in 13 % of
AML patients , all pertaining to the group of
patients exhibiting high
IL-3Ralpha expression . -
pubmed
These findings suggest that in
AML , deregulated expression of
IL-3Ralpha may contribute to the proliferative advantage of the leukemic blasts and , hence , to a poor prognosis . -
pubmed
Fetoplacental
leptin levels and their relation to birth weight and
insulin in gestational
diabetic pregnant
women . -
pubmed
To investigate the fetoplacental
leptin circulation in
gestational diabetes , we compared cord
leptin and
insulin levels in 17 healthy pregnant
women and 17
women with gestational - onset
diabetes . -
pubmed
Similarly ,
leptin levels in umbilical veins ( mean+/-4.59+/-1.60 ng / ml ) were significantly ( P<0.001 ) higher than those in umbilical arteries ( mean+/-SD 2.08+/-0.90 ng / ml ) in
gestational diabetes . -
pubmed
However ,
leptin levels in umbilical veins were significantly higher ( P<0.002 ) in
gestational diabetes than those in controls . -
pubmed
Additionally , in women with
diabetes but not in controls , the birth weight and the cord
leptin concentrations were positively related to cord
insulin levels . -
pubmed
We conclude that there is a
hyperleptinaemia in the fetoplacental circulation in pregnant
women with
carbohydrate intolerance and in these cases
insulin and
leptin may have antagonist roles regarding fetal development . -
pubmed
Human herpesvirus 8 (
HHV-8 ) or
Kaposi ' s sarcoma - associated herpesvirus , implicated in the pathogenesis of
Kaposi ' s sarcoma , utilizes
heparan sulfate - like molecules to bind the target cells via its envelope - associated glycoproteins
gB and
gpK8.1A. -
pubmed
These findings suggest that
HHV-8 - gB could mediate cell adhesion via its RGD motif interaction with the cell surface
integrin molecules and indicate the induction of cellular signaling pathways , which may play roles in the
infection of target cells and in
Kaposi ' s sarcoma pathogenesis . -
pubmed
RESULTS : Only 3.4 % of
CKD patients had their
PTH assessed prior to RRT , and 0.3 % had
vitamin D status measured . -
pubmed
HBcAg concentrations correlated very closely with
HBV DNA ( r = 0.946 , n = 145 ) in 216 samples from 72
hepatitis B patients . -
pubmed
Expression profiling identified processes likely responsible for
18 - fluoro-2 - deoxy - glucose uptake and
tumor localization by positron emission tomography , and a role for
hypoxia - inducible factor-1 was suggested . -
pubmed
Potentially important up - regulated genes included
gp96 ,
lung resistance - related protein ,
galectin-3 binding protein , the M(r ) 67,000
laminin receptor ( on
tumor vessels ) , and voltage - dependent anion channels . -
pubmed
Obesity raises blood pressure by increasing renal tubular reabsorption , impairing pressure natriuresis , causing volume expansion due to activation of the sympathetic nervous system and
renin -
angiotensin system , and by physical compression of the kidneys , especially when visceral
obesity is present . -
pubmed
[
HAPTOGLOBINS AND BLOOD GROUPS IN
FAMILIAL MULTIPLE SCLEROSIS ] . -
pubmed
A STUDY OF BLEACHING OF THE FUNDUS OCULI IN
PIGMENTARY DEGENERATIONS OF THE RETINA . -
pubmed
[ ON THE EFFECT OF THE
ENZYME INHIBITOR
TRASYLOL IN THE THERAPY AND PROPHYLAXIS OF
ACUTE PANCREATITIS : REPORT BASED ON 893 CASES ] . -
pubmed
METHODS : The inhibition of
tyrosine kinase may represent a novel approach in the treatment of
spinal cord ischemia reperfusion injury . -
pubmed
Recently , a family of
tyrosine kinase inhibitors , the
tyrphostins , has been successfully used in models of
endotoxemia ,
peritonitis , and
hypovolemic shock . -
pubmed
CONCLUSIONS :
Tyrphostin Ag 556 alters
spinal cord ischemia reperfusion injury by inhibiting
protein kinases . -
pubmed
Adenoviral ( Ad ) vectors were produced to overexpress
EGFRvIII in vitro or in xenograft
tumors in vivo . -
pubmed
RESULTS : The presence of
EGFRvIII was verified in all xenograft
tumors tested with no detectable expression in the corresponding cells under in vitro culture conditions . -
pubmed
MDA - MB-231 xenograft
tumors demonstrated
EGFRvIII expression levels , which were 1.9 - fold higher relative to
EGFRwt compared to a 14.5 - fold higher
Tyr - P. Ionizing radiation of these
tumors at 4 Gy induced an average 3.2 - fold increase in
EGFRvIII Tyr - P.
EGFRvIII expression in
U-373 MG cells significantly enhanced survival after 4Gy , which was completely abolished by dominant - negative
EGFR -
CD533 . -
pubmed
Finally , the ability of
EGFRvIII to accelerate
tumor growth during irradiation was confirmed in vivo . -
pubmed
CONCLUSION :
EGFRvIII is frequently expressed in a variety of different
tumor types and can confer significant radioresistance , thus further providing evidence for
EGFRvIII as an additional important target in our approaches to radiosensitize
malignant solid tumors . -
pubmed
Burkholderia cenocepacia H111 , which was isolated from a
cystic fibrosis patient , employs a quorum - sensing ( QS ) system , encoded by
cep , to control the expression of virulence factors as well as the formation of biofilms . -
pubmed
Thus ,
AidA appears to be required for establishing an
infection - like process rather than acting as a toxin . -
pubmed
BACKGROUND : To assess the role of
alkaline phosphatase (
AP ) ,
gamil - glutamyltransferase (
gammaGT ) and abdominal ultrasound ( US ) as predictors of
choledocholithiasis in
patients sustaining acute
biliary pancreatitis . -
pubmed
Naive
CD4(+ ) T cells in
RA are contracted in diversity and restricted in clonal burst . -
pubmed
We conducted a multicenter phase II study to evaluate the efficacy and tolerability of the
docetaxel plus
epirubicin combination chemotherapy as first - line treatment in
MBC and performed a prospective assessment of the predictive values of circulating
HER2 extracellular domain (
ECD ) and
vascular endothelial growth factor (
VEGF ) . -
pubmed
We concluded that the
docetaxel and
epirubicin combination is an effective first - line treatment in
MBC patients and that elevated serum
HER2 ECD levels , but not circulating
VEGF levels , predict a poor outcome . -
pubmed
OBJECTIVE : A recent single - center multivariate analysis of hepatitis C (
HCV ) patients showed that having any two criteria : 1 )
ferritin & gt ; or = 200 microg / l and 2 ) spider nevi and/or
albumin & lt ; or = 35 g / l predicted grade 2 or greater histological
inflammation ; the presence of any two of the following criteria :
spider nevi , platelets & lt ; or = 150 x 109 / l , palpable
splenomegaly and/or
albumin & lt ; or = 35 g / l predicted stage 2 or greater histological
fibrosis . -
pubmed
Targeted deletion of
metalloproteinase 9 attenuates experimental
colitis in
mice : central role of epithelial - derived
MMP . -
pubmed
BACKGROUND & amp ; AIMS : There is mounting evidence that
matrix metalloproteinases are the predominant proteinases expressed in the gut mucosa during active
inflammatory bowel disease . -
pubmed
We investigated the role of
metalloproteinase 9 (
MMP-9 ) , a secreted
gelatinase that is consistently up - regulated in both animal models and
human inflammatory bowel disease and is associated with disease severity , in the pathogenesis of
colitis by using
mice containing a targeted deletion of the
MMP-9 gene . -
pubmed
RESULTS :
MMP-9 activity and protein expression were absent from
normal colonic mucosa but were up - regulated during experimental
colitis . -
pubmed
MMP-9-/-
mice exposed to dextran sodium sulfate or
salmonella had a significantly reduced extent and severity of
colitis . -
pubmed
Immunohistochemical studies showed that
MMP-9 was localized to epithelial cells and granulocytes during active
colitis . -
pubmed
Neutrophil transmigration studies and bone marrow chimeras showed that neutrophil
MMP-9 is neither required for its migration nor sufficient to induce tissue damage during
colitis and that epithelial
MMP-9 is important for tissue damage . -
pubmed
MMP-9 inhibited cell attachment and
wound healing in the model intestinal epithelial cell line ,
Caco2 - BBE . -
pubmed
CONCLUSIONS : Taken together , our data suggest that
MMP-9 expressed by epithelial cells may play an important role in the development of
colitis by modulating cell - matrix interaction and
wound healing . -
pubmed
Purification and characterization of
human kallikrein 11 , a candidate
prostate and ovarian cancer biomarker , from seminal plasma . -
pubmed
PURPOSE : Preliminary data suggest that
hK11 is a novel serum biomarker for
prostate and ovarian cancer . -
pubmed
Empiric treatments include the use of
calcium channel blockers ,
steroids , induced
hypertension or blood pressure lowering , and rarely endovascular therapy . -
pubmed
Activity of
PXD101 , a
histone deacetylase inhibitor , in preclinical
ovarian cancer studies . -
pubmed
In the current investigation , we examined the activity of
PXD101 , a potent
histone deacetylase inhibitor , used alone or in combination with clinically relevant chemotherapeutics (
docetaxel ,
paclitaxel , and
carboplatin ) , in preclinical in vitro and in vivo models of
ovarian cancer . -
pubmed
Shrimp (
Penaeus monodon )
anti - lipopolysaccharide factor reduces the lethality of
Pseudomonas aeruginosa sepsis in
mice . -
pubmed
Due to its multifunctional properties , the
SALF(55 - 76 ) cyclic peptide may become an important prophylaxis against and therapy for
bacterial infectious diseases , as well as for
septic shock . -
pubmed
Despite this heterogeneity , up to 50 % of
prelingual recessive non - syndromic deafness can be attributed to mutations in the
GJB2 gene (
Connexin-26 ,
gap - junction protein ) . -
pubmed
Activities of
prolyl endopeptidase and
dipeptidyl peptidase IV in brain structures of
rats with
dopamine deficiency - dependent
MPTP - induced
depressive syndrome . -
pubmed
The development of
MPTP - induced
depressive syndrome in
rats was accompanied by activation of
prolyl endopeptidase and
dipeptidyl peptidase IV in the brain frontal cortex . -
pubmed
OBJECTIVE : Limited data on
patients undergoing Roux - en - Y gastric bypass surgery ( RY - GBP ) suggest that an improvement in
insulin secretion after surgery occurs rapidly and thus may not be wholly accounted for by
weight loss . -
pubmed
RESEARCH DESIGN AND METHODS : Incretin (
gastric inhibitory peptide [ GIP ] and
glucagon - like peptide-1 [
GLP-1 ] ) levels and their effect on
insulin secretion were measured before and 1 month after RY - GBP in eight obese
women with
type 2 diabetes and in seven obese nondiabetic control
subjects . -
pubmed
RESULTS : Fasting and stimulated levels of
GLP-1 and
GIP were not different between control
subjects and
patients with
type 2 diabetes before the surgery . -
pubmed
Wnt signaling in
polycystic kidney disease . -
pubmed
Some
polycystic kidney disease proteins , such as
Inversin and
Bardet - Biedl syndrome family members , were found to use components of the Wnt signaling cascade to orient cells along a secondary polarity axis within the plane of the epithelium . -
pubmed
Expression of oncofetal
fibronectin mRNA in
thyroid anaplastic carcinoma . -
pubmed
BACKGROUND :
Oncofetal fibronectin (
onfFN ) is a fetal protein , the expression of which is observed in
papillary thyroid carcinomas but not in
follicular tumors or in normal thyroid . -
pubmed
METHODS : We examined the expression levels of
onfFN mRNA in
ATC tissues and cell lines derived from ATC by real - time quantitative reverse transcription - polymerase chain reaction ( PCR ) and in situ hybridization . -
pubmed
RESULTS : Increased expression of
onfFN mRNA was observed in all cases of
ATC regardless of the type of accompanying differentiated
carcinoma and five of six ATC cell lines . -
pubmed
Furthermore , expression of
onfFN mRNA was observed in the majority of
ATC cells in all six tissues examined by in situ hybridization . -
pubmed
CONCLUSION : These results confirm that expression of
onfFN mRNA characterizes not only
papillary thyroid carcinoma but also
ATC . -
pubmed
onfFN mRNA or protein may be a useful marker to identify
anaplastic carcinoma cells and may be considered as an optimistic target in molecular - based therapy of
ATC . -
pubmed
Treatment of biochemical recurrence of
prostate cancer with
granulocyte - macrophage colony - stimulating factor secreting , allogeneic , cellular immunotherapy . -
pubmed
MATERIALS AND METHODS :
Patients with noncastrate
prostate cancer ( 19 ) with biochemical (
prostate specific antigen ) recurrence following prostatectomy or radiation therapy and no radiological evidence of metastasis were enrolled in the study . -
pubmed
CONCLUSIONS :
Granulocyte - macrophage colony - stimulating factor secreting cellular immunotherapy has a favorable toxicity profile with signals of clinical and immunological activity against
hormone naive prostate cancer . -
pubmed
( 2008 ) Two single nucleotide polymorphisms identify the highest - risk
diabetes HLA genotype :
Diabetes 57:3152 - 3155 , 2008 . -
pubmed
Interaction between
renin -
angiotensin and sympathetic nervous systems in a
rat model of
pressure overload cardiac hypertrophy . -
pubmed
A large fraction of this resides in the DCT , namely , ( i ) the
transient receptor potential channel melastatin subtype 6 (
TRPM6 ) , a divalent cation - permeable channel located at the luminal membrane of the DCT , facilitates
Mg ( 2 + ) entry from the pro - urine into the cell ; ( ii ) the
epidermal growth factor is a novel hormone regulating active
Mg ( 2 + ) transport through
TRPM6 ; ( iii ) the voltage - gated
K (+ ) channel ,
Kv1.1 , establishes a favorable luminal membrane potential for
TRPM6 - mediated
Mg ( 2 + ) transport ; ( iv ) the
Na (+)/ K (+)- ATPase gamma - subunit (
gamma - Na (+)/ K (+)- ATPase ) was identified as mutated protein in a family with isolated dominant
hypomagnesemia . -
pubmed
The molecular mechanism by which
gamma - Na (+)/ K (+)- ATPase is involved in DCT
Mg ( 2 + ) handling remains unknown ; ( v ) a high percentage of
patients with mutations in the renal transcription factor
HNF1B (
hepatocyte nuclear factor 1 homeobox B ) gene develop
hypomagnesemia ; and ( vi )
Gitelman and EAST / SeSAME syndrome patients suffer from a similar
tubulopathy due to mutations in
NCC (
NaCl cotransporter ) and
Kir4.1 , respectively . -
pubmed
In these patients , decreased expression of
TRPM6 is proposed to cause
hypomagnesemia . -
pubmed
Concentrations of
von Willebrand factor (
vWF ) and
factor VIII are lower in
individuals with blood group 0 compared to subjects with blood group A , B or AB , which might in turn result in a reduced inhibition of
platelet aggregation in
individuals with blood group 0 . -
pubmed
Association between
FokI polymorphism in
vitamin D receptor gene and susceptibility to
spinal tuberculosis in Chinese Han population . -
pubmed
BACKGROUND AND AIMS : Studies have shown that the
vitamin D receptor (
VDR ) gene polymorphisms may be associated with
pulmonary tuberculosis (
TB ) and play important roles in the regulation of
calcium in a variety of tissues including bone . -
pubmed
To our knowledge , however , whether
FokI polymorphism in
VDR gene is associated with susceptibility to
spinal TB is still unknown . -
pubmed
We undertook this study to investigate the association between
FokI polymorphism in
VDR gene and susceptibility to
spinal TB in Chinese Han population . -
pubmed
FokI polymorphism in
VDR gene was analyzed by polymerase chain reaction - restriction fragment length polymorphism ( PCR - RFLP ) in the
spinal TB group and the control group . -
pubmed
CONCLUSIONS :
FokI polymorphism in
VDR gene may be associated with the susceptibility to
spinal TB in Chinese Han population . -
pubmed
The significance of strong
histone deacetylase 1 expression in the progression of
prostate cancer . -
pubmed
AIMS : Histone deacetylases (
HDACs ) play important roles in many types of
cancer . -
pubmed
Recently , it has been reported that
HDAC1 expression in
prostate cancer is significantly higher than in benign prostate cell lines and tissues . -
pubmed
The expression of
HDAC1 in association with the clinicopathological data was investigated to define its functional and pathological roles in
prostate cancer . -
pubmed
METHODS AND RESULTS :
HDAC1 expression was examined immunohistochemically in 148
patients with
prostate cancer . -
pubmed
Strong expression of
HDAC1 in benign prostate glands ,
high - grade prostatic intraepithelial neoplasia (
PIN ) and
prostate cancer was observed in 17/148 ( 11 % ) , 19/71 ( 27 % ) and 69/148 ( 47 % )
patients . -
pubmed
CONCLUSIONS : These results indicate that overexpression of
HDAC1 contributes to progression and poor prognosis in
prostate cancer . -
pubmed
Cd treatments led to a decline in
mycorrhizal infection ( MI ) , nodule number and dry weights which was accompanied by reductions in
leghemoglobin content ,
nitrogenase activity , organic acid contents . -
pubmed
Although there is little evidence that
PMT might have a role in
human cancer , it serves as an important and novel paradigm for a bacterial link to
cancer . -
pubmed
Polyneuropathy ,
organomegaly ,
endocrinopathy ,
M - protein , and
skin changes (
POEMS ) syndrome is a
multisystem disorder associated with
plasma cell dyscrasia . -
pubmed
Elevated serum levels of
vascular endothelial growth factor (
VEGF ) , which strongly promotes neovascularization and vasopermeability , are considered to be responsible for the characteristic symptoms such as
angiomata ,
pleural effusion /
ascites ,
edema , and
organomegaly in the disorder . -
pubmed
To study whether other angiogenetic factors are upregulated in
POEMS syndrome , we measured serum levels of
basic fibroblast growth factor and
hepatocyte growth factor (
HGF ) , as well as
VEGF , in 17
patients with
POEMS syndrome . -
pubmed
These results suggest that different angiogenetic factors might contribute to the pathogenesis of
POEMS syndrome , and this fact might contribute to the insufficient clinical effects obtained by suppression of
VEGF alone . -
pubmed
HSR also resulted in prominent histopathological damage , including
congestion ,
edema , cellular infiltration and
hemorrhage . -
pubmed
The protective effects of
CO against
lung injury were notably associated with an increase in the protein expression level of
peroxisome proliferator - activated receptor ( PPAR )- gamma , an anti - inflammatory transcriptional regulator in the lung . -
pubmed
These findings suggest that inhalation of
CO at a low concentration exerts a potent therapeutic effect against HSR - induced
ALI and attenuates the inflammatory cascade by increasing
PPAR - gamma protein expression . -
pubmed
The
STAT5 Inhibitor
Pimozide Displays Efficacy in Models of
Acute Myelogenous Leukemia Driven by
FLT3 Mutations . -
pubmed
Activation of the
transcription factor STAT5 is essential for the pathogenesis of
acute myelogenous leukemia (
AML ) containing the
FLT3 internal tandem duplication ( ITD ) mutation . -
pubmed
FLT3 ITD is a constitutively active
tyrosine kinase that drives the activation of
STAT5 , leading to the growth and survival of
AML cells . -
pubmed
Pimozide inhibits the
tyrosine phosphorylation of
STAT5 , leading to the death of
AML cells through the induction of apoptosis . -
pubmed
Significantly ,
pimozide reduces the
tumor burden in a
mouse model of
FLT3 - driven
AML . -
pubmed
Therefore , identifying
STAT5 inhibitors may provide a new avenue for the treatment of
AML , and these may be effective alone or in combination with
tyrosine kinase inhibitors . -
pubmed
The
HSP90 inhibitor
NVP - AUY922 - AG inhibits the
PI3 K and
IKK signalling pathways and synergizes with
cytarabine in
acute myeloid leukaemia cells . -
pubmed
HSP90 inhibition potentially facilitates the simultaneous targeting of multiple molecules within
tumour cells and represents an attractive therapeutic proposition . -
pubmed
Here , we investigated
HSP90 as a molecular target for
acute myeloid leukaemia (
AML ) using the novel
HSP90 inhibitor
NVP - AUY922 - AG . -
pubmed
This study shows that the novel
HSP90 inhibitor
NVP - AUY922 - AG has significant single agent activity in
AML cells and is synergistic with
Ara - C. -
pubmed
Scleredema is a form of
cutaneous mucinosis caused by an increased accumulation of
collagen and mucin in the dermis . -
pubmed
[ Block effects of
BDNF antibody on
MEK expression in lung of
rats with
brain ischemia ] . -
pubmed
UNLABELLED : OBJECITVE : To explore the block effect of
brain - derived neurotrophic factor (
BDNF ) antibody on the
mitogen extracellular kinase (
MEK ) expression in lung tissues of
rats with
brain ischemia . -
pubmed
METHODS : Adult SD
rats were divided into sham group ,
brain ischemia lung injury ( BILI ) group , and
BDNF antibody treated group . -
pubmed
RT - PCR showed that
BDNF antibody block significantly decreased the expressional level of
MEK mRNA in the lung tissues with
brain ischemia ( P<0.05 ) . -
pubmed
CONCLUSION :
BDNF antibody block leads to a significant reduction of
MEK expression in endothelia cells of lung tissue in the
rats with
brain ischemia . -
pubmed
Every quarter , mean levels and prevalence of conformity were collected for the following indicators :
anemia , dialysis dose , serum
calcium and
phosphorus ,
PTH ,
25OH - vitamin D ,
albumin , serum
bicarbonate ,
LDL -
cholesterol , serum
beta2 - microglobulin , systolic and diastolic blood pressure , intradialytic
hypotension and vascular access . -
pubmed
Finally , we suggest that the definition and targets of some indicators , especially
hypertension and
LDL -
cholesterol , be reviewed , since evidence of their association with mortality is not demonstrated . -
pubmed
Initial investigations revealed
atrial fibrillation (
AF ) and
pericardial effusion , further investigations unraveled
primary hypothyroidism (
thyroid stimulating hormone ) of 34.7 muIU / ml and total
thyroxine ( T4 ) of 5.57 mug / dl ) . -
pubmed
Eight months after the start of chemotherapy , 9 courses had been administered , the
carcinoembryonic antigen (
CEA)/
carbohydrate antigen ( CA ) 19 - 9 level had decreased to the reference value , and the decrease in size of the
liver metastases indicated a partial response ( PR ) , as assessed by CT . -
pubmed
Microbial heat shock proteins (
HSP ) play an important role of in the pathogenesis of
autoimmune diseases because of the high level of sequence homology with
human HSP . -
pubmed
RATIONALE : Post - intravenous recombinant
tissue plasminogen activator (
r - tPA ) orolingual
angioedema (
PIROLA ) , including the life - threatening form , is an underappreciated complication of
ischaemic stroke treatment . -
pubmed
RESULTS : Of the 129 acute
ischaemic stroke patients treated at Bourg - en - Bresse between 2010 and 2012 , four
patients , all receiving
angiotensin converting enzyme inhibitor ( ACEI ) , developed a PIROLA ( cumulative incidence rate : 32 % ) . -
pubmed
Association between single
nucleotide polymorphisms of
asporin (
ASPN ) and
BMP5 with the risk of
knee osteoarthritis in a Chinese Han population . -
pubmed
The aim of this study was to investigate associations between single nucleotide polymorphisms rs13301537 in
asporin (
ASPN ) and rs373444 in the
bone morphogenetic protein 5 (
BMP5 ) gene with
knee osteoarthritis (
OA ) susceptibility in a Chinese Han population . -
pubmed
ASPN rs13301537 and
BMP5 rs373444 polymorphisms were genotyped in patients with
knee OA and age- and sex - matched
OA - free controls from a Chinese Han population . -
pubmed
In contrast , the CT and CC genotypes of rs373444 in
BMP5 were not significantly associated with the risk of
knee OA , even after further stratification analysis according to age or sex . -
pubmed
Our results showed that
ASPN rs13301537 T to C change and variant C genotype may contribute to
knee OA risk in a Chinese Han population . -
pubmed
However , there is no available information on whether
alpha - PA affects gene expression in
leukemia cells . -
pubmed
Effect of
caffeine and
adenosine receptor ligands on the expression of spike - and - wave discharges in Genetic
Absence Epilepsy Rats from Strasbourg ( GAERS ) . -
pubmed
Autocrine
human growth hormone stimulates the
tumor initiating capacity and metastasis of
estrogen receptor - negative
mammary carcinoma cells . -
pubmed
We demonstrated herein that autocrine
hGH promoted
cancer stem cell ( CSC)-like properties of
estrogen receptor - negative
mammary carcinoma ( ER - MC ) cells in vitro . -
pubmed
In xenograft studies , autocrine
hGH increased the
tumor initiating capacity of
ER - MC cells . -
pubmed
Thus , inhibition of
hGH is a potential therapeutic strategy to prevent
tumor initiation and metastasis of
ER - MC . -
pubmed
The antitumor immune response generated by fractionated radiation therapy may be limited by
tumor cell adaptive resistance and can be circumvented by
PD - L1 blockade . -
pubmed
We demonstrated that fractionated RT led to increased
tumor cell expression of
programmed cell death ligand 1 (
PD - L1 ) in response to
CD8 + T cell production of
interferon gamma . -
pubmed
Increased circulating
interleukin-17 levels in
preeclampsia . -
pubmed
We determined circulating levels of
interleukin-17 (
IL-17 ) along with those of angiogenic factors in healthy nonpregnant and pregnant
women and
preeclamptic patients , and examined whether serum
IL-17 levels of
preeclamptic patients were related to their clinical features and angiogenic factor concentrations . -
pubmed
We did not find any relationship between serum
IL-17 concentrations of
preeclamptic patients and their clinical features and serum
sFlt-1 and
PlGF levels or
sFlt-1 /
PlGF ratios . -
pubmed
However , elevated serum
IL-17 level and
sFlt-1 /
PlGF ratio were found to have an additive effect on the risk of
preeclampsia , as shown by the substantially higher odds ratios of a combination of the two than of either alone . -
pubmed
In conclusion , serum
IL-17 levels are increased in
preeclampsia , which may contribute to the development of the excessive systemic inflammatory response characteristic of the maternal syndrome of the disease . -
pubmed
In addition , elevated serum
IL-17 level and
sFlt-1 /
PlGF ratio had an additive ( joint ) effect on the risk of
preeclampsia . -
pubmed
The transcription factor
Nrf2 - mediated antioxidant response represents a critical cellular defense mechanism ; however , emerging data suggest that constitutive activation of
Nrf2 is associated with
cancer development and chemotherapy resistance . -
pubmed
The reasons
Nrf2 continuously accumulates in
cancer cells remain to be fully understood . -
pubmed
Mediobasal hypothalamic overexpression of
DEPTOR protects against high - fat diet - induced
obesity . -
pubmed
RESULTS : We first report that systemic ( brain and periphery ) overexpression of
DEPTOR prevents high - fat diet - induced
obesity , improves
glucose metabolism and protects against
hepatic steatosis . -
pubmed
AIM : A high level of
matrix metalloproteinase 9 (
MMP-9 ) is a predictor of poor
wound healing in
diabetic foot ulcers . -
pubmed
Here , we aimed to explore the changes of
alpha - KG and its relationship with
MMP-9 and
TET2 during
diabetic wound healing . -
pubmed
RESULTS : The levels of
alpha - KG ,
TET2 and
MMP-9 were significantly increased in
diabetic wound compared with nondiabetic wound ( P = 0 010 , 0 016 and 0 025 ) . -
pubmed
CONCLUSIONS : The levels of
alpha - KG ,
TET2 and
MMP-9 were significantly increased in
diabetic wound compared with
nondiabetic wound . -
pubmed
Immunohistochemistry of AVN preparations revealed increased
fibrosis and gap junction protein (
connexin43 and 40 ) remodelling in the AVN of LVD
animals compared to sham . -
pubmed
High Risk
HPV E6 /
E7 Oncoprotein Expression in Women with
High Grade Squamous Intraepithelial Lesion . -
pubmed
PURPOSE : To correlate the expression of high - risk
HPV E6 mRNA with pap smear , colposcopy , and biopsy results in
women with
high grade squamous intraepithelial lesion (
HSIL ) . -
pubmed
Pap smear tests revealed that the
E6 /
E7 test was positive in 107 ( 83.8 % ) women with atypical squamous cells - high grade (
ASC - H ) ,
HSIL , or higher . -
pubmed
When analyzing the association with colposcopy results , the frequency of positive
E6 /
E7 results increased with the severity of the
injury , ranging from 57.1 % in women without colposcopy - detected
injury to 86.5 % in those with higher levels of colposcopy findings . -
pubmed
Of the 111 women who underwent biopsy and
E6 /
E7 testing , the
E6 /
E7 test was positive in 84.7 % of the women who presented with
lesions of cervical intraepithelial neoplasia (
CIN ) grade 2 or higher . -
pubmed
CONCLUSIONS :
E6 /
E7 mRNA expression was higher in women with
HSIL and
CIN grade 2 or higher . -
pubmed
JNK Activation Contributes to Oxidative Stress - Induced Parthanatos in
Glioma Cells via Increase of Intracellular ROS Production . -
pubmed
In this study , we used
glioma cell lines and
H2O2 to investigate the role of
JNK in
glioma cell parthanatos induced by oxidative stress . -
pubmed
We found that exposure to
H2O2 not only induced intracellular accumulation of ROS but also resulted in
glioma cell death in a concentration- and incubation time - dependent manner , which was accompanied with cytoplasmic formation of PAR polymer , expressional upregulation of
PARP-1 , mitochondrial depolarization , and
AIF translocation to nucleus . -
pubmed
Pharmacological inhibition of
PARP-1 with 3AB or genetic knockdown of its level with siRNA rescued
glioma cell death , as well as suppressed cytoplasmic accumulation of PAR polymer and nuclear translocation of
AIF , which were consistent with the definition of parthanatos . -
pubmed
Either attenuation of intracellular ROS with antioxidant
NAC or inhibition of
JNK phosphorylation with
SP600125 or
JNK siRNA could significantly prevent
H2O2 - induced parthanatos in
glioma cells . -
pubmed
Thus , we demonstrated that
JNK activation contributes to
glioma cell parthanatos caused by oxidative stress via increase of intracellular ROS generation . -
pubmed
Immunotherapy of
non - Hodgkin ' s lymphoma with a defined ratio of
CD8 + and
CD4 +
CD19 - specific chimeric antigen receptor - modified T cells . -
pubmed
CD19 - specific chimeric antigen receptor ( CAR)-modified T cells have antitumor activity in
B cell malignancies , but factors that affect toxicity and efficacy have been difficult to define because of differences in lymphodepletion and heterogeneity of CAR - T cells administered to individual
patients . -
pubmed
We conducted a clinical trial in which
CD19 CAR - T cells were manufactured from defined T cell subsets and administered in a 1:1
CD4(+)/
CD8(+ ) ratio of CAR - T cells to 32
adults with relapsed and/or refractory B cell
non - Hodgkin ' s lymphoma after
cyclophosphamide ( Cy)-based lymphodepletion chemotherapy with or without
fludarabine (
Flu ) . -
pubmed
Astragaloside IV protects against podocyte injury via
SERCA2 - dependent ER stress reduction and
AMPKalpha - regulated autophagy induction in
streptozotocin - induced
diabetic nephropathy . -
pubmed
Moreover ,
diabetes or HG - induced podocyte apoptosis was markedly attenuated by AS - IV , paralleled by a marked remission in ER stress and a remarkable restoration in impaired autophagy , which were associated with a significant improvement in the expression of
sarcoendoplasmic reticulum Ca2 + ATPase 2b (
SERCA2b ) and
AMP - activated protein kinase alpha (
AMPKalpha ) phosphorylation , respectively . -
pubmed
Collectively , these results suggest that
AS - IV prevented the progression of
DN , which is mediated at least in part by
SERCA2 - dependent ER stress attenuation and
AMPKalpha - promoted autophagy induction . -
pubmed
Docosahexaenoic acid enrichment in
NAFLD is associated with improvements in hepatic metabolism and hepatic
insulin sensitivity : a pilot study . -
pubmed
NP cells robustly expressed isoforms
CA9 / 12 , which were
hypoxia - inducible . -
pubmed
In addition to increased mRNA stability under
hypoxia , we observed binding of
HIF-1alpha to select
hypoxia - responsive elements on CA9/12 promoters using genomic chromatin immunoprecipitation . -
pubmed
Taken together , our studies show for the first time that
bicarbonate buffering through the
HIF-1alpha - CA axis is critical for NP cell survival in the
hypoxic niche of the intervertebral disc . -
pubmed
Particularly , anticardiolipin antibodies ,
anti - beta2 - glycoprotein I antibodies and lupus anticoagulant are essential tools for
APS diagnosis . -
pubmed
Germline pathogenic variants in
ALK and
PHOX2B , as well as other
cancer predisposition genes , are increasingly implicated in the pathogenesis of
neuroblastic tumors . -
pubmed
The algorithm correctly identified all six children (
Beckwith - Wiedemann ( n = 2 ) ,
Fanconi anemia ,
RB1 ,
PHOX2B , chromosome duplication involving ALK ) as requiring a genetic evaluation by using clinical features present at diagnosis . -
pubmed
RESULTS : Mean
Hb concentration was similar ( 11.0 vs 11.0 g / dL ) in patients treated in both countries and the proportion of patients within KDIGO
anemia target was 69.5 % in Poland vs 65.8 % in Portugal ( NS ) . -
pubmed
Correction to : Unexpected Benefit from
Alpelisib and
Fulvestrant in a Woman with Highly Pre - treated
ER - Positive ,
HER2 - Negative
PIK3CA Mutant Metastatic
Breast Cancer . -
pubmed
[ Effect of Scalp Penetration Acupuncture on the Expression of
NGF in Brain Tissue around
Hematoma of
Intracerebral Hemorrhage Rats ] . -
pubmed
Objective To observe the effects of scalp penetration acupuncture on the expression of
nerve growth factor (
NGF ) in brain tissue around
hematoma of
intracerebral hemorrhage rats . -
pubmed
The expression of
NGF positive cells in brain tissue around
hematoma was detected using immunohistochemical method . -
pubmed
Immunohistochemistry with a pan -
TRK antibody distinguishes secretory
carcinoma of the salivary gland from
acinic cell carcinoma . -
pubmed
AIMS :
Secretory carcinoma ( previously known as
mammary analogue secretory carcinoma ) is characterised by
ETV6 rearrangements , most often
ETV6 -
NTRK3 fusion . -
pubmed
A recently developed pan -
TRK antibody shows promise for identifying
tumours with
NTRK fusions . -
pubmed
The aim of this study was to evaluate the utility of pan -
TRK immunohistochemistry in distinguishing secretory
carcinoma from mimics . -
pubmed
METHODS AND RESULTS : We examined whole - tissue sections from 86
tumours , including 14 secretory
carcinomas ( 12
parotid primaries and one buccal primary , and one metastasis ; five with
ETV6 rearrangement confirmed by fluorescence in - situ hybridisation , and one with
ETV6 -
NTRK3 fusion and one with
ETV6 -
RET fusion detected by targeted sequencing ) , 14
acinic cell carcinomas , 18 polymorphous
adenocarcinomas , 20
low - grade mucoepidermoid carcinomas , and 20
pleomorphic adenomas . -
pubmed
Pan -
TRK staining was detected in nine ( 64 % ) secretory
carcinomas , all with a nuclear pattern and four with diffuse staining ( & gt;50 % of cells ) . -
pubmed
Among other
tumour types , pan -
TRK immunoreactivity was observed in all ( 100 % ) pleomorphic
adenomas ( particularly myoepithelial cell - rich , myxoid areas ) , 15 ( 83 % ) polymorphous
adenocarcinomas , and four ( 20 % )
low - grade mucoepidermoid carcinomas , all with predominantly membranous / cytoplasmic immunoreactivity ; only six cases showed focal ( & lt;10 % ) nuclear staining . -
pubmed
CONCLUSIONS : Although pan -
TRK expression is not entirely sensitive or specific for secretory
carcinoma , nuclear staining distinguishes secretory
carcinoma from mimics . -
pubmed
Acinic cell carcinomas are negative for pan -
TRK , though membranous expression of
TRK is common in other
salivary gland neoplasms . -
pubmed
The lack of pan -
TRK immunoreactivity in a subset of
secretory carcinomas may suggest non -
NTRK fusion partners . -
pubmed
Supplementation with whole
garlic attenuated HFD - enhanced ratio of serum
GPT / GOT (
glutamic - pyruvic transaminase /
glutamic - oxaloacetic transaminase ) , levels of T - Cho ( total
cholesterol ) and LDLs (
low - density lipoproteins ) , and index of homeostatic model assessment for
insulin resistance ( HOMA - IR ) , but had no significant effect in the levels of serum
HDL - c (
high density lipoprotein cholesterol ) , TG ( total
triacylglycerol ) , and
glucose . -
pubmed
Biomarker discovery applied to
myalgic encephalomyelitis /
chronic fatigue syndrome (
ME /
CFS ) , a disabling disease of inconclusive aetiology , has identified several
cytokines to potentially fulfil a role as a quantitative blood / serum marker for laboratory diagnosis , with
activin B a recent addition . -
pubmed
Previous pilot study results showed that
activin B was significantly elevated for the
ME /
CFS participants compared to healthy ( control ) participants . -
pubmed
A significant difference for serum
activin B was also detected for
ME /
CFS and control cohorts recruited for this study , but median levels were significantly lower for the ME /
CFS cohort . -
pubmed
A closer analysis revealed that the inclusion of
activin B to the panel of pathology markers improved the prediction of mild to moderate
ME /
CFS cases . -
pubmed
OBJECTIVE : The elevated expression of
phospholamban (
PLB ) has been observed in
heart failure and cardiac remodeling , inhibiting the affinity of
Ca2 + pump to
Ca2 + thereby impairing heart relaxation . -
pubmed
METHODS AND RESULTS : A
mouse model specifically deleted
HuR in cardiomyocytes were used for testing the role of
HuR in regulating
PLB during
isoproterenol (
ISO)-induced
cardiac remodeling . -
pubmed
However , deletion of
HuR in cardiomyocytes mitigated the effect of
ISO in inducing
PLB expression and reducing
beta1 - AR expression , in turn aggravating
ISO - induced
myocardial hypertrophy and
cardiac fibrosis . -
pubmed
Role of
JNK Signaling Pathway in
Dexmedetomidine Post - Conditioning - Induced Reduction of the Inflammatory Response and Autophagy Effect of Focal
Cerebral Ischemia Reperfusion Injury in
Rats . -
pubmed
The escape latency ( EL ) ;
cerebral infarction area ratio ; positive apoptosis ; neuron pathological changes ; auto - phagosome numbers ; inflammatory factor contents ; mRNA and protein expressions of
Beclin-1 ,
Caspase-3 and
LC3II / I ; and the phosphorylation level of
JNK were decreased , while the times across platform and the times stayed in the quadrant of the original platform were increased after
dexmedetomidine treatment . -
pubmed
However , the protective effect of
dexmedetomidine on
brain injury in
MCAO rats was reversed by
JNK pathway activator . -
pubmed
Decreased H3K9 acetylation level of
LXRalpha mediated
dexamethasone - induced
placental cholesterol transport dysfunction . -
pubmed
Atopic inflammation is complex largely due to the various
cytokines which affect eosinophil activation , proliferation , differentiation , and survival . -
pubmed
Pathogenic variants in
NUBPL result in failure to assemble the matrix arm of complex I and cause a complex
leukoencephalopathy with thalamic involvement . -
pubmed
Recently , genetic changes in the complex I assembly factor
NUBPL have been characterized by a consistent recognizable pattern of
leukoencephalopathy affecting deep white matter including the corpus callosum and cerebellum . -
pubmed
Compromised
NUBPL activity impairs assembly of the matrix arm of complex I and produces a severe , rapidly - progressive
leukoencephalopathy with thalamic involvement on MRI , further expanding the neuroimaging phenotype . -
pubmed
Here , we discovered that
PDDOL , a natural variation allele of
PLEIOTROPIC DEVELOPMENTAL DEFECTS (
PDD ) , leads to pleiotropic
developmental defects in a near - isogenic line generated by introgressing the wild
rice Oryza longistaminata into the
rice (
Oryza sativa ) cultivar 187R. -
pubmed
beta - Thalassemia is an
inherited single gene disorder related to reduced synthesis of the
beta - globin chain of hemoglobin . -
pubmed
Effects of Reduced
Connexin43 Function on Mandibular Morphology and Osteogenesis in Mutant
Mouse Models of
Oculodentodigital Dysplasia . -
pubmed
Mutations in the gene encoding the gap - junctional protein
connexin43 (
Cx43 ) are the cause of the
human disease
oculodentodigital dysplasia (
ODDD ) . -
pubmed
Using two mutant
mouse models that mimic the
ODDD phenotype ( I130T/+ and G60S/+ ) , we sought to uncover how altered
Cx43 function may affect mandibular development . -
pubmed
Overall , our results suggest that the morphological differences seen in
G60S/+ and I130T/+
mouse mandibles are due to delayed ossification and suggest that mechanical forces may exacerbate the effects of
ODDD on the skeleton . -
pubmed
CONCLUSION :
AD - related immune hub genes include
B2 M ,
FYN ,
PIK3R1 , and
PIK3CA , and lncRNAs LINC00836 and
DCTN1 -
AS1 potentially contribute to
AD immune - related phenomena by regulating
AD - related hub genes . -
pubmed
Epidermal growth factor receptor (
EGFR ) is over - expressed in many
cancer cells and is a good target for
cancer therapy . -
pubmed
CONCLUSIONS : This study clearly demonstrated that the anti -
EGFR sdAbs could inhibit
cancer cell growth in vitro and
tumor growth in vivo . -
pubmed
AIMS : Whether or not renal structural changes , especially
arteriolar hyalinosis , are related to the rate of renal functional decline and increase in urinary
albumin excretion ( UAE ) at the early stage of
diabetic nephropathy in
patients with
type 2 diabetes is still unknown . -
pubmed
IgG1 subclass restriction of
oligoclonal IgG from cerebrospinal fluids and brain extracts in
patients with
multiple sclerosis and
subacute encephalitides . -
pubmed
Oligoclonal -
IgG - containing cerebrospinal fluids ( CSF ) from
patients with
multiple sclerosis and
subacute encephalitides were studied for
IgG subclass distribution by immunoelectrophoretic and hemagglutination inhibition methods . -
pubmed
A case of
plasma cell leukemia , secreting
light kappa chains , is reported . -
pubmed
Glycoprotein concentration at cell extremities was accompanied by preferential maturation of virus particles from the same sites ; both
vesicular stomatitis and influenza viruses budded predominantly from the vicinity of clustered blebs . -
pubmed
This permissive action of
growth hormone has been initially suggested by observation in
growth hormone - deficient
rats ,
mice (
dwarf mutants , and
humans ( sporadic , hereditary or acquired
growth hormone deficiency.(ABSTRACT TRUNCATED AT 400 WORDS ) -
pubmed
Anti -
insulin autoantibodies were detected by an ELISA assay in all the
NOD mice studied throughout the entire period of observation . -
pubmed
Autoantibodies reacting with the cytoplasm of islet cells in Bouin 's fixed pancreas sections , likely to be anti -
insulin antibodies , were found in 47 to 58 % of the samples from
NOD mice aged 75 to 150 days . -
pubmed
A panel of 10
FITC - labelled
lectins (
MPA , PNA ,
ConA , DBA , SBA , RCA-120 , WGA ,
UEA ,
GS - I ,
GS - II+ ) was applied to cryosections of seven specimens of
normal urothelium . -
pubmed
Blood
angiotensinase activity in relation to the breakdown of
angiotensin II amide and nonisotopic
phenylthiocarbamyl - angiotensin II amide in
hypertensive and normotensive
patients . -
pubmed
Patients with
T cruzi infection have antibody to
GP90 , whereas patients with
leishmaniasis do not and the two
infections can be distinguished in an ELISA system using this antigen . -
pubmed
Circulating immune complexes and complement breakdown product
C3d in
glomerulonephritis and kidney transplantation . -
pubmed
Circulating immune complexes (
CIC ) and the complement breakdown product
C3d were measured in 81
patients with
glomerulonephritis (
GN ) , 28
patients with early and 25
patients with long - term renal transplants . -
pubmed
In
patients with
GN ,
CIC were detected in 19 and elevated
C3d levels found in 45
patients . -
pubmed
The highest levels of
C3d were found in
patients with membranoproliferative GN type I and II , diffuse sclerosing
GN and
GN secondary to
SLE and
Wegener ' s granulomatosis . -
pubmed
No relationship was found between CIC and
C3d , and the combination of CIC with
C3d measurements did not help to characterize ' nephritogenic '
CIC . -
pubmed
C3d was frequently elevated in
patients with
impaired renal function which may reflect an inflammatory '
nephritic ' process , but may also be due to a reduced renal elimination . -
pubmed
Furthermore
C3d was frequently elevated in
patients with improving or decreasing renal function , and in
patients with heavy
proteinuria . -
pubmed
CIC and elevated
C3d were not related to onset of acute rejection episodes in early transplant
patients nor to late
renal graft failure . -
pubmed
HBV DNA detected in the above assay was predominantly cytoplasmic ; it was associated with the presence of
hepatitis B core antigen (
HBcAg ) in hepatocytes and
HBeAg in serum , and to a lesser extent with
cirrhosis and immunosuppression , but not with the presence of
HBsAg in hepatocytes , nor with histological evidence of disease activity judged by the presence of piece - meal
necrosis and
lobular and portal tract inflammation . -
pubmed
These findings support the view that liver
HBcAg and serum
HBeAg are markers of virus replication , and demonstrate that active
liver disease in
HBsAg - positive patients may occur with or without such markers of replication . -
pubmed
[
C - reactive protein and orosomucoid as parameters of developmental monitoring and therapeutic effectiveness in
neonatal sepsis ] . -
pubmed
They propose serial determination of
C - reactive - protein and an efficient control of treatment in
neonatal sepsis . -
pubmed
Among the serum samples analysed , increasing proportions of proteolysed
IGFBP-3 were found in the following order :
acromegalic patients , normal
subjects ,
GH - deficient patients , pregnant
women . -
pubmed
The aim of this study was to assess the behavior of fasting serum
glucose ,
C - peptide levels and OGTT in
pancreatic cancer follow - up . -
pubmed
[ Evaluation of
serum adenosine deaminase as a prognostic marker in the treatment of
human immunodeficiency virus infection with
zidovudine ] . -
pubmed
Wnt-1 null mutants exhibit
cranial defects but no
spinal cord abnormalities , despite expression of the gene in these regions . -
pubmed
The absence of
spinal cord abnormalities is thought to be due to a functional compensation of the
Wnt-1 deficiency by related genes , a problem that has complicated the analysis of null mutants of other developmental genes as well . -
pubmed
We induce similar mid- and
hindbrain abnormalities as those seen in the
Wnt-1 null mutant
mice . -
pubmed
Attenuation of
Wnt-1 expression was also associated with
cardiomegaly resulting in hemostasis . -
pubmed
These findings are consistent with the possibility that a subset of
Wnt-1 expressing cells include neural crest cells known to contribute to septation of the
truncus arteriosus and to formation of the visceral arches . -
pubmed
Tumor necrosis factor - alpha in
malignant disease . -
pubmed
PURPOSE : Due to its important role in immunoregulation , we have investigated serum levels of
tumor necrosis factor - alpha (
TNF alpha ) , in
children with newly diagnosed , untreated ,
malignant disease . -
pubmed
PATIENTS AND METHODS : These levels have been related to the presence of
infection and to the serum content of three other
cytokines , namely
interleukin-1 beta ,
interleukin-2 , and
interferon - gamma . -
pubmed
RESULTS :
Children with
leukemia had higher mean levels of
TNF alpha ( 63.6 + /- 12.3 pg / ml ) than did
children with
solid tumors ( 21.5 + /- 4.2 pg / ml ) and control
patients ( 10.5 + /- 2.6 pg / ml ) . -
pubmed
TNF alpha levels in
patients did not correlate with the levels of the other
cytokines or with the presence of
infection . -
pubmed
CONCLUSIONS :
Children with
malignant disease often have elevated
TNF alpha levels . -
pubmed
This elevation is dependent on the malignant disease process itself , and could either reflect the host immunological response or
tumor cell production of
TNF alpha . -
pubmed
Analysis of
dystrophin gene deletions in patients from the Mexican population with
Duchenne / Becker muscular dystrophy . -
pubmed
On the basis of increased
plasma renin activity and serum
17 alpha - hydroxyprogesterone concentration and decreased
21 - hydroxylase activity of the
adenoma tissue , the
patient was diagnosed as having
systemic 21 - hydroxylase deficiency . -
pubmed
In cases of
adrenal incidentalomas with
21 - hydroxylase deficiency , the indications for surgical removal should be carefully considered . -
pubmed
Treatment of
woodchuck hepatitis virus infection in vivo with
2 ' , - 3 '- dideoxycytidine (
ddC ) and
2 ',- 3 '- dideoxycytidine monophosphate coupled to
lactosaminated human serum albumin (
L - HSA ddCMP ) . -
pubmed
Comparison of immunological changes between subcutaneous and intravenous route of administration of
IL-2 in
cancer patients . -
pubmed
The effects of the route of administration of
interleukin 2 (
IL-2 ) on the immunological parameters of
patients with various
malignancies were investigated . -
pubmed
These results demonstrate that there is no significant difference in the immunological parameters in
cancer patients receiving
IL-2 via subcutaneous or intravenous routes and provide further support for the current trend for clinical trials to concentrate on
outpatients subcutaneous administration . -
pubmed
hCG research remains necessary for pregnancy diagnosis , but
hCG dosage is essential only in case of programmed medical assistance or pathological pregnancy (
extrauterine pregnancy ,
hydatiform mole ,
choriocarcinoma ) . -
pubmed
Over the last 4 - 5 years , there have been numerous reports on the discovery of small molecule inhibitors for potential therapeutic applications to a number of
proliferative diseases , principally
cancer and
restenosis , where the over - expression of certain
tyrosine kinases has been demonstrated . -
pubmed
Further , NSAIDs may delay the healing of
gastric mucosal ulcer , in part through suppression of
HGF expression via inhibition of endogenous PG production . -
pubmed
[ Circadian and seasonal variations of the activity of
blood lymphocyte dehydrogenases during
secondary immunodeficiency in
women with
acute inflammatory gynecologic diseases of nonspecific etiology ] . -
pubmed
When
GluR2 promoter activity was investigated by plasmid transfection into cultured cortical neurons , cortical glia , and
C6 glioma cells , the promoter construct with the strongest activity , per
transfected cell , was 29.4 - fold ( + /- 3.7 ) more active in neurons than in non - neural cells . -
pubmed
Anticardiolipin antibodies ( aCL ) found in sera from
patients with
antiphospholipid syndrome recognize a cryptic epitope that appears on the
beta2 - glycoprotein I (
beta2 - GPI ) molecule when
beta2 - GPI interacts with a lipid membrane composed of negatively charged
phospholipid or when
beta2 - GPI is adsorbed on a polyoxygenated
polystyrene plate . -
pubmed
Nerve fibers and
class II major histocompatibility complex (
MHC ) antigen - expressing dendritic cells have been known to gather in the dental pulp beneath
carious lesions . -
pubmed
In pulps affected by early
caries , HLA - DR - positive dendritic cells aggregated mainly in the cell - free zone associated with bundles of
PGP 9.5 - immuno - reactive nerve fibers . -
pubmed
In pulps affected by advanced
caries , the accumulated HLA - DR - positive cells and
PGP 9.5 - immunoreactive nerve fibers showed close association with each other especially beneath the odontoblast layer : the cells even embraced the nerve fibers . -
pubmed
The immunoreactivity for
HLA - DR in Schwann cells depended upon the severity of the
carious lesion . -
pubmed
Differential glycosylation of the
Cas - Br - E env protein is associated with retrovirus - induced
spongiform neurodegeneration . -
pubmed
Specifically , the expression of
gp70 correlated with regions showing
microglial infection and
spongiform neurodegeneration . -
pubmed
In contrast , regions high in
neuronal infection and without neurodegenerative changes ( the cerebellum and olfactory bulb ) were characterized by a
gp65 Env protein isoform . -
pubmed
Taken together , these results indicate that differential posttranslational modification of the
Cas - Br - E Env is associated with a failure to incorporate certain
Env isoforms into virions in vivo , suggesting that defective viral assembly may be associated with the induction of
spongiform neurodegeneration . -
pubmed
However ,
hypothyroidism may present in a manner suggestive of an acute
myocardial infarction with an elevated
creatine kinase and electrocardiographic abnormalities . -
pubmed
Human white matter from non - neurologic cases ,
multiple sclerosis (
MS ) and other
neurologic diseases (
OND , inflammatory and non - inflammatory ) , was subjected to immunocytochemistry and Western blotting for expression of the
neuregulin ,
glial growth factor-2 (
GGF2 ) , and its receptors ,
erbB2 ,
erbB3 and
erbB4 . -
pubmed
GGF2 has previously been shown to have mitogenic effects upon oligodendrocytes in vitro and an enhancing effect upon remyelination in
animals with
autoimmune demyelination . -
pubmed
In all types of
human white matter examined , expression of the ligand
GGF2 and its three receptors was consistently found on oligodendrocytes , with higher levels being seen in cases of
MS . -
pubmed
GGF2 and
erbB receptor expression did not correlate with areas of remyelination and reactivity occurred throughout the tissue , with some increase in intensity at the edge of
MS lesions . -
pubmed
Ciliary activity in
allergics who developed a stress response postantigen challenge , as determined by an induction of the
27 kDa stress ( heat shock ) protein , displayed no
ciliary dysfunction when exposed to a pH 5 stress . -
pubmed
In this case , a stress sufficient to provoke a
heat shock ( stress ) protein (
HSP ) response ( but not one that produced more severe
lung injury and did not provoke an HSP response ) protected cells from a subsequent acid stress . -
pubmed
RESEARCH DESIGN AND METHODS : A total of 18
patients after heart transplantation for
end - stage heart disease ( age 47 + /- 3 years ; transplant age 5.5 + /- 1.5 years ; BMI 25.8 + /- 0.8 kg / m(2 ) ;
cyclosporin A 4.2 + /- 0.6 mg/[kg.day ] ;
azathioprine 0.87 + /- 0.31 mg/[kg.day ] ) , 12
patients with
type 2 diabetes (
D - Tx ) , and 6
patients without
type 2 diabetes (
Tx ) were studied by means of 1 ) an oral
glucose tolerance test ( OGTT ) to assess the beta - cell secretory response , 2 ) a euglycemic - hyperinsulinemic ( 1 mU/[kg.min ] ) clamp combined with indirect calorimetry and a primed continuous infusion of
[ 6,6 - 2H2 ] glucose and
[ 1 - 13C ] leucine to measure postabsorptive and
insulin - stimulated
carbohydrate and protein metabolism , and 3 ) 1H - NMR spectroscopy of the
calf muscles to measure intramyocellular
triglyceride ( IMCL ) content . -
pubmed
OBJECTIVE : To examine , in a retrospective analysis of outcome based on
prostate - specific antigen (
PSA ) levels , whether the 1992 and revised 1997 staging criteria for
prostate cancer can be used to predict progression - free survival for
patients after radical prostatectomy for pT2 and pT3
prostate cancer . -
pubmed
The subgroups of pT2 and pT3
disease were compared for the time to
PSA progression , using Kaplan - Meier data analysis and the log - rank test . -
pubmed
Molecular studies have confirmed that it is a heterogeneous disorder and there may be evidence for an autosomal recessive mode of inheritance.1 The gene responsible for
Noonan ' syndrome has been mapped to the long arm of chromosome 12.2,3 The
human deltex gene (
DLT x 1 ) , mapping to chromosomal region 12q24 in the vicinity of the
Noonan ' s syndrome critical region is being evaluated as a candidate gene for this disorder.4 Various types of
musculoskeletal abnormalities have been reported , including
short stature ,
craniofacial dysmorphism ,
short or webbed neck and fetal pads in fingers and toes.5 We report five cases with the unusual physical features of overriding toes and simian creases . -
pubmed
Electrophysiologic data indicated a diagnosis of
MG and
chronic inflammatory demyelinating polyneuropathy ;
acetylcholine receptor antibody was elevated at 4.1 nmol / L ( normal < 2 nmol / L ) . -
pubmed
Quinoline resistance in
malaria is frequently compared with
P - glycoprotein - mediated multidrug resistance ( mdr ) in mammalian cells . -
pubmed
Monitoring of
IgE - mediated
food allergy in childhood . -
pubmed
UNLABELLED : Testing for
IgE - mediated
allergy is performed to reach or refute a suspected
allergy . -
pubmed
Influence of
orthostatic hypotension in
Parkinson ' s disease on plasma
atrial natriuretic peptide . -
pubmed
The effect of
orthostatic hypotension in
Parkinson ' s disease (
PD ) on plasma
atrial natriuretic peptide (
ANP ) was examined in fifteen
individuals with
PD without
autonomic dysfunction ( 63 - 85 years ) , nine
PD patients with
autonomic dysfunction (
orthostatic hypotension ; systolic BP change & gt ; 20 mmHg after 5 min standing : 69 - 82 years ) and 14 fit elderly
volunteers ( 62 - 93 years ) . -
pubmed
The mean
ANP level was 42.2 pg / ml ( range 16.8 - 89.2 pg / ml ) in the PD group without
autonomic dysfunction ; 44.4 pg / ml ( range 27.2 - 91.2 pg / ml ) in the
PD group with
autonomic dysfunction ; and 48.5 pg / ml ( range 22.2 - 111.6 pg / ml ) in the elderly group . -
pubmed
Targeted deletion of the
SSTK gene in
mice resulted in
male sterility due to profound impairment in motility and morphology of spermatozoa . -
pubmed
Insulin decrease following OE treatment was greater in lean CR than in H
rats , but this trend was reversed in the
obese rats , lacking effective responses to
leptin . -
pubmed
Being in a position that is likely to control well - characterized oncogene products suggested that the expression levels of the
Sprouty genes may be relevant in
human carcinogenesis . -
pubmed
Early data on the deregulation of
Sprouty expression in
breast , prostate and liver cancers is discussed along with the notion that some of them might have potential as
tumour markers or that the derived proteins may act as
tumour suppressors . -
pubmed
The relationship between serum concentration of
cardiac troponin I in
chronic renal failure patients and cardiovascular events . -
pubmed
OBJECTIVE : The purpose of this study was to evaluate the relationship between
serum cardiac troponin I in asymptomatic
chronic renal failure patients and cardiovascular events . -
pubmed
CONCLUSION : Elevated
cTnI concentrations are commonly found in
chronic renal failure patients . -
pubmed
The AMI cutoff level of
cTnI ( 0.4 ng / ml ) seem to have a benefit for predicting the cardiovascular events in asymptomatic
chronic renal failure patients while the 0.08 ng / ml cutoff does n't have usefulness for this purpose . -
pubmed
Mice heterozygous for a targeted disruption of the
cystathionine beta - synthase gene (
Cbs+/- ) and wild - type littermates (
Cbs+/+ ) were fed either a control diet or a high
methionine / low
folate ( HM / LF ) diet for 6 to 8 months to produce graded
hyperhomocysteinemia . -
pubmed
Carotid artery thrombosis was not accelerated in
mice deficient in
endothelial nitric oxide synthase (
Nos3 ) , which suggests that decreased endothelium - derived
nitric oxide is not a sufficient mechanism for enhancement of
thrombosis . -
pubmed
We conclude that
hyperhomocysteinemia enhances susceptibility to
arterial thrombosis through a mechanism that is not caused by loss of endothelium - derived
nitric oxide but may involve oxidative stress and impairment of the
protein C anticoagulant pathway . -
pubmed
Alphastatin downregulates vascular endothelial cells
sphingosine kinase activity and suppresses
tumor growth in
nude mice bearing
human gastric cancer xenografts . -
pubmed
AIM : To investigate whether
alphastatin could inhibit
human gastric cancer growth and furthermore whether
sphingosine kinase (
SPK ) activity is involved in this process . -
pubmed
Micro vessel density was analyzed in
Factor VIII - stained
tumor sections by the immunohistochemical SP method . -
pubmed
CONCLUSION : Downregulating ECs
SPK activity may be one of the mechanisms that
alphastatin inhibits
gastric cancer angiogenesis . -
pubmed
Identifying
helicase specific - inhibitors may lead to the development of drugs in the treatment of
human cancers . -
pubmed
Pain - related
anxiety - like behavior requires
CRF1 receptors in the amygdala . -
pubmed
Corticotropin - releasing factor receptor CRF1 has been implicated in the neurobiological mechanisms of
anxiety and
depression . -
pubmed
This study tested the hypothesis that
CRF1 receptors in the amygdala are critically involved in
pain - related
anxiety . -
pubmed
This study shows for the first time that
CRF1 receptors in the amygdala contribute critically to
pain - related
anxiety - like behavior and nocifensive responses in a model of
arthritic pain . -
pubmed
We demonstrate that
mitogen - activated protein kinase - activated kinase-2 (
MK2 ) is essential for localized Th2 - type inflammation and development of experimental
asthma . -
pubmed
Thus , the
MK2 -
HSP27 pathway is an excellent target for therapeutic control of localized
inflammatory diseases . -
pubmed
In this work , we demonstrated that the growth of the
murine fibrosarcoma MC - C , was accompanied by manifestations of
systemic inflammation , as demonstrated by an increase in both the number of circulating polymorphonuclear neutrophils ( PMN ) and the serum concentration of the proinflammatory
cytokines interleukin-1beta (
IL-1beta ) ,
interleukin-6 (
IL-6 ) and
tumor necrosis factor - alpha (
TNF - alpha ) and the acute phase proteins C reactive (
CRP ) and
serum A amyloid (
SAA ) . -
pubmed
Multivariate analysis demonstrated that independent predictors of MRSA
bacteraemia ( vs. no
bacteraemia ) were injection drug use ( IDU ) ,
end - stage renal disease (
ESRD ) and
CD4 count & lt;200 cells / microL. -
pubmed
CONCLUSIONS : MRSA
bacteraemia was an increasingly common diagnosis in our
HIV - infected cohort , especially in patients with history of IDU , low
CD4 cell count and
ESRD . -
pubmed
Phase 2 study of
gemcitabine and
irinotecan in metastatic
breast cancer with correlatives to determine
topoisomerase I localization as a predictor of response . -
pubmed
BACKGROUND :
Gemcitabine incorporation into DNA enhances cleavage complexes in vitro when combined with
topoisomerase I inhibitors and demonstrates synergy in
cancer cells when given with
irinotecan . -
pubmed
Topoisomerase I localization can be measured in metastatic
breast cancer . -
pubmed
Zap-70 positive
chronic lymphocytic leukemia co - existing with
Jak 2 V671F positive
essential thrombocythemia : a common defective stem cell ? -
pubmed
We report two cases of
ET with
Jak 2 V617F in
Zap-70 +
CLL . -
pubmed
Zap-70 expression in
CLL correlates with non - mutated immunoglobulin genes . -
pubmed
In DTg
mice ,
Ang II - induced
left ventricle hypertrophy and
diastolic dysfunction without affecting systolic function , as assessed by echography . -
pubmed
These effects were associated with an increase in the expression of
collagens and
fibronectin ,
matrix metalloproteinase 2 and
matrix metalloproteinase 9 activities , and histological
fibrosis . -
pubmed
Ang II treatment of DTg
mice did not affect
inflammation markers , but oxidative stress was substantially increased , as indicated by
gp91 expression ,
apocynin - inhibitable
NADPH oxidase activity , and protein carbonylation . -
pubmed
This observation may be relevant to the clinical use of MR or of combined
Ang II type 1 receptor -
MR antagonists for
hypertrophic cardiomyopathies or for
heart failure , particularly when
diastolic dysfunction is associated with preserved systolic function . -
pubmed
Intratumoral
MVD was determined after
mouse antihuman
CD31 antibody immunostaining . -
pubmed
In conclusion , we propose that HMC05 may be a safe and potent herbal formula against
vascular inflammation , and its action may be attributable to the inhibition of ROS- and
NF - kappaB - dependent expression of
adhesion molecules and
chemokines . -
pubmed
Role of the
AMPKgamma3 isoform in
hypoxia - stimulated
glucose transport in glycolytic skeletal muscle . -
pubmed
We determined the role of the
AMPKgamma3 isoform in
hypoxia - mediated energy status signaling and
glucose transport in fast - twitch glycolytic extensor digitorum longus ( EDL ) muscle from
AMPKgamma3 - knockout ( KO )
mice and wild - type
mice . -
pubmed
Although
hypoxia increased
glucose transport ( P & lt ; 0.001 ) in wild - type
mice , this effect was attenuated in
AMPKgamma3 - KO
mice ( 45 % reduction , P & lt ; 0.01 ) . -
pubmed
KN-93 exposure reduced
hypoxia - mediated
glucose transport in
AMPKgamma3 - KO and wild - type
mice ( P & lt ; 0.05 ) . -
pubmed
Basal and
hypoxia - mediated phosphorylation of
CaMKII ,
AMPK , and
ACC as well as alpha1- and alpha2 - associated
AMPK activity was comparable between
AMPKgamma3 - KO and wild - type
mice . -
pubmed
KN-93 reduced
hypoxia - mediated
CaMKII phosphorylation in
AMPKgamma3 - KO and wild - type
mice ( P & lt ; 0.05 ) , whereas phosphorylation of
AMPK and
ACC as well as alpha1- and alpha2 - associated
AMPK activity was unaltered . -
pubmed
Taken together , we provide direct evidence for a role of the
AMPKgamma3 isoform in
hypoxia - mediated
glucose transport in glycolytic muscle . -
pubmed
Moreover ,
hypoxia - mediated
TBC1D1 / D4 phosphorylation was uncoupled from
glucose transport in
AMPKgamma3 - KO
mice , indicating that
TBC1D1 / D4 - independent mechanisms contribute to
glucose transport in skeletal muscle . -
pubmed
Here , we discuss the different hypotheses to explain the induction of
CD8(+ ) T cell responses in
mycobacterial infections . -
pubmed
Cap myopathy caused by a mutation of the
skeletal alpha - actin gene
ACTA1 . -
pubmed
Mutations in
TPM2 and
TPM3 genes have been reported in
cap myopathy so far . -
pubmed
In addition to a new
ACTA1 gene mutation , our case emphasizes the genetic heterogeneity of
cap myopathy and its association with
ACTA1 gene as well as the importance of repeat muscle biopsy in
patients with undiagnosed
muscle weakness . -
pubmed
METHODS : To explore the renoprotective role of
C - peptide in
diabetic nephropathy (
DN ) , we reviewed the literature using PubMed for English language articles that contained key words related to
C - peptide , kidney and DN . -
pubmed
RESULTS : Numerous studies have demonstrated that
C - peptide ameliorates a number of the structural and functional renal disturbances associated with uncontrolled
hyperglycaemia in
human and
animal models of
type 1 diabetes mellitus that lead to the development and progression of
nephropathy , including abrogation of glomerular hyperfiltration , reduced
microalbuminuria , decreased mesangial expansion and increased
endothelial nitric oxide synthase levels . -
pubmed
CONCLUSION : Burgeoning studies suggest that C - peptide is more than merely a link between the A and B chains of the
proinsulin molecule and represents a future therapeutic tool in reducing complications of
DN . -
pubmed
Hashimoto ' s thyroiditis :
TGAb ,
TPOAb ,
TRAb and recovery from
hypothyroidism . -
pubmed
Thyroglobulin antibody (
TGAb ) and
thyroid peroxidase antibody (
TPOAb ) have been used to diagnose
Hashimoto ' s thyroiditis . -
pubmed
Patients with positive
TGAb and/or
TPOAb have been assumed to have
Hashimoto ' s thyroiditis . -
pubmed
Approximately 10 % of those with positive
TGAb and/or
TPOAb have
hypothyroidism . -
pubmed
TSBAb causes
thyroid atrophy and
hypothyroidism . -
pubmed
TGAb and/or
TPOAb do not necessarily cause
hypothyroidism . -
pubmed
Ischemia reperfusion induces
IFN regulatory factor 4 in renal dendritic cells , which suppresses postischemic
inflammation and prevents
acute renal failure . -
pubmed
Ischemia reperfusion ( IR ) activates
TLRs causing subsequent sterile
inflammation , for example in postischemic
acute renal failure . -
pubmed
We hypothesized that certain factors suppress
APC activation and thereby limit sterile
renal inflammation , for example ,
IFN regulatory factor 4 (
IRF-4 ) , an inducible inhibitor of LPS signaling . -
pubmed
Lack of
IRF4 aggravated
acute renal failure 24 h after renal artery clamping together with increased intrarenal expression of
TNF - alpha ,
IL-6 ,
CXCL2 , and
CCL2 as well as excessive tubular
necrosis and peritubular neutrophil influx as compared with wild - type IR kidneys . -
pubmed
This effect almost entirely depended on the role of
IRF4 to suppress
TNF - alpha release by intrarenal APCs because either
clodronate liposome depletion of these cells or
TNF - alpha blockade with etanercept entirely abrogated the aggravation of
cytokine expression and
acute renal failure in
Irf4 - deficient
mice . -
pubmed
Thus , loss - of - function mutations in the IRF4 gene predispose to
IR injury because the postischemic induction of
IRF4 in resident APCs like CD11c(+ ) dendritic cells , suppresses them to secrete
TNF - alpha , and thereby limits inappropriate immunopathology . -
pubmed
The BH3 - only protein
Bad confers
breast cancer taxane sensitivity through a nonapoptotic mechanism . -
pubmed
In this paper we report that the proapoptotic BH3 - only protein
Bad has a major role in
taxane - induced cell death in vitro , and clinically is a prognostic indicator for overall survival of
breast cancer patients after adjuvant
taxane chemotherapy . -
pubmed
They also suggest that cells expressing
Bad are more sensitive to
taxanes because of their altered cell cycle dynamics and reveal a clinically relevant proliferative role of
Bad in
breast cancer . -
pubmed
Definition of ubiquitination modulator
COP1 as a novel therapeutic target in
human hepatocellular carcinoma . -
pubmed
The ubiquitination modulator
COP1 regulates
p53 activity by ubiquitination and it is frequently overexpressed in
human HCC . -
pubmed
In this study , we tested the hypothesis that
COP1 blockade by short interfering RNA ( siRNA)-mediated inhibition could affect the course of
HCC progression . -
pubmed
The
COP1 isoform
COP1 - 1 was selected as the most effective target for siRNAs in terms of growth inhibition and apoptotic induction in several
HCC cell lines . -
pubmed
Growth inhibition occurred in
HCC cells that retained wild - type
p53 or expressed mutant
p53 ( Y220C or R249S ) , whereas
p53 - null
Hep3B cells were resistant . -
pubmed
In an orthotopic
mouse xenograft model of
HCC , systemic delivery of a modified
COP1 siRNA by stable nucleic acid - lipid particles suppressed neoplastic growth in liver without unwanted immune responses . -
pubmed
Our findings offer a first proof of principle that
COP1 can be a promising target for systemic therapy of
HCC . -
pubmed
PURPOSE : To characterize the population pharmacokinetics of subcutaneous ustekinumab , a
human IgG1Kappa ; monoclonal antibody against
interleukin-12 / 23p40 , using data from a randomized , double - blind , placebo - controlled Phase II study in
patients with active
psoriatic arthritis (
PsA ) . -
pubmed
Moreover , formation of intercellular gaps in endothelial monolayers was observed , exposing subendothelial extracellular matrix ( ECM ) on which
colon carcinoma cells adhered via
integrin molecules . -
pubmed
Fluoro - Jade labeling revealed that marked loss of
CGRP - imunoreactive DRG sensory neurons is not due to
neuronal degeneration . -
pubmed
Therapeutic strategies to target multiple
kinases in
glioblastoma . -
pubmed
Despite the initial enthusiasm in exploring
kinase inhibitors for
GBM , first - generation
kinase inhibitors that selectively disrupt single kinases have failed to demonstrate clinical benefit in most
patients with
GBM . -
pubmed
One strategy to circumvent this challenge is to target multiple
kinases by multitargeted
kinase inhibitors or combinations of single targeted
kinase inhibitors , both of which have been evaluated in clinical trials for
GBM . -
pubmed
Fascioloides magna infected deer with fibrous capsules and
migratory lesions had significantly higher values for
lactate dehydrogenase (
LDH ) ,
glutamate dehydrogenase (
GLDH ) and
globulin , and lower values for
albumin /
globulin ratio and
glucose compared to uninfected deer . -
pubmed
Transient receptor potential channels (
TRPs ) regulate
tumor growth via
calcium - dependent mechanisms . -
pubmed
The ( thermosensitive )
capsaicin receptor
TRPV1 is overexpressed in numerous highly aggressive
cancers . -
pubmed
TRPV1 has potent antiproliferative activity and is therefore potentially applicable in targeted therapy of
malignancies . -
pubmed
Recently , we characterized
TRPM8 functions in
pancreatic neuroendocrine tumors ( NETs ) , however , the role of
TRPV1 is unknown . -
pubmed
To confirm the role of
IL-16 in
CAV development , C - H-2(bm12)KhEg ( H-2(bm12 ) ) donor hearts were transplanted into C57BL/6J WT recipients treated with ( 1 ) anti -
IL-16 - neutralization monoclonal antibody or ( b ) control
immunoglobulin G. -
pubmed
Donor hearts transplanted into
IL-16(-/- ) recipients had a significant reduction in
coronary artery luminal occlusion , intima - to - media ratio , and percentage of diseased vessels . -
pubmed
CAV was associated with decreased
donor organ inflammation , as well as donor organ
cytokine (
IL-1beta and
IL-6 ) and
chemokine (
MCP-1 and
KC ) protein expression . -
pubmed
,
Feline Immunodeficiency Virus (
FIV ) , and
Toxoplasma gondii IgG were detected in all three species with mean respective prevalence as follows : puma 16 % , 41 % and 75 % ; bobcat 31 % , 22 % and 43 % ; domestic cat 45 % , 10 % and 1 % . -
pubmed
Using this
Lactococcus lactis expressing the
PAMI , we prepared yogurt and fed it to
diabetic mice models . -
pubmed
OBJECTIVE : To determine the effect of increasing oral doses of
vitamin D ( 3 ) on serum
25 -( OH ) D and
serum parathyroid hormone (
PTH ) levels in postmenopausal white
women with
vitamin D insufficiency ( defined as a
25 -[ OH ] D level & lt;=50 nmol / L ) in the presence of adequate
calcium intake . -
pubmed
Inhibition of
factor XI activation attenuates
inflammation and
coagulopathy while improving the survival of
mouse polymicrobial sepsis . -
pubmed
Because activation of the
contact proteases factor XII (
FXII ) ,
prekallikrein , and
factor XI (
FXI ) can trigger coagulation and inflammatory responses , the contact factors have been considered potential targets for the treatment of
sepsis . -
pubmed
We therefore investigated whether an anticoagulant antibody ( 14E11 ) that selectively inhibits prothrombotic
FXI activation by activated
FXII (
FXIIa ) modifies the course of bowel perforation - induced
peritoneal sepsis in
mice . -
pubmed
These data suggest that severe polymicrobial
abdominal infection induces prothrombotic
FXI activation , to the detriment of the host . -
pubmed
Systemic anticoagulation by inhibiting
FXI activation or
FXIIa procoagulant activity during
sepsis may therefore limit the development of
disseminated intravascular coagulation without increasing
bleeding risks . -
pubmed
The WAKE - UP trial is an investigator initiated , European , randomized , double - blind , placebo - controlled trial designed to test efficacy and safety of MRI - based thrombolysis with alteplase (
tPA ) in
stroke patients with unknown time of symptom onset , e.g. -
pubmed
Chromatin remodelling enzymes such as the
histone deacetylases (
HDACs ) and histone demethylases such as
lysine - specific demethylase 1 (
LSD1 ) have been validated as targets for
cancer drug discovery . -
pubmed
We have developed multiple series of
HDAC inhibitors and
LSD1 inhibitors that promote the re - expression of aberrantly silenced genes that are important in
human cancer . -
pubmed
The
arginine methyltransferase
PRMT5 -
MEP50 is required for embryogenesis and is misregulated in many
cancers . -
pubmed
Presenilin comprises the catalytic subunit of
gamma - secretase , a
protease responsible for the generation of amyloid - beta peptides causative of
Alzheimer disease . -
pubmed
Adaptive responses to
tissue injury : role of
heme oxygenase-1 . -
pubmed
Bone - seeking tracers like
99mTc - DPD and
pyrophosphate are beginning to have a role in imaging
transthyretin cardiac amyloidosis . -
pubmed
Circulating
interleukin-8 and
plasminogen activator inhibitor-1 are increased in
women with
ovarian carcinoma . -
pubmed
Elevated serum levels of several
cytokines have been reported in
ovarian cancer . -
pubmed
The aims of this study were to evaluate the diagnostic and prognostic value of multiple serum
cytokines in
women with
ovarian tumors , and to examine possible associations between serum levels of
cytokines and the previously analyzed
HGF . -
pubmed
Preoperative levels of multiple
cytokines were quantified by serum - based immunoassays in 113
women with a
pelvic mass : 57
carcinomas , 23 borderline
tumors , and 33 benign
ovarian tumors . -
pubmed
The
women with ovarian
carcinoma had significantly higher preoperative serum levels of
cancer antigen 125 (
CA 125 ) ,
interleukin 8 (
IL-8 ) , and
plasminogen activator inhibitor-1 (
PAI-1 ) than
women with benign
ovarian tumors . -
pubmed
Serum levels of
IL-8 and
PAI-1 were elevated in
women with
ovarian carcinoma compared to
women with benign
ovarian tumors , and positively correlated to serum
HGF levels in
women with
ovarian tumors . -
pubmed
Urinary protease inhibitor
Serpin B3 is higher in women and is further increased in female
patients affected by
aldosterone producing
adenoma . -
pubmed
The proteomic analysis showed a different expression of
Serpin B3 Inhibitor -
SCCA1 (
SB3 ) in APA and
BAH patients . -
pubmed
Neither messenger RNA nor
SB3 protein were identified in tissue obtained from
adrenal tumors and from the surrounding normal gland . -
pubmed
Altogether , this work details the striatal subsynaptic distribution of some of the main
nAChRs subunits , underlining the possible relevance of striatal
nAChRs in controlling neurotransmission , with potential relevance for
Parkinson ' s disease ,
nicotine addiction and other
dopaminergic disorders . -
pubmed
TPH2 gene polymorphisms in the regulatory region are associated with
paranoid schizophrenia in Northern Han Chinese . -
pubmed
Single
nucleotide polymorphisms ( SNPs ) in the regulatory regions of
TPH2 gene may affect gene expression and biosynthesis of
5 - HT triggering to various
neuropsychiatric disorders related to 5 - HT dysfunction . -
pubmed
The present study explored the association of SNPs within the
TPH2 gene with
paranoid schizophrenia in Han Chinese . -
pubmed
A total of 164 patients with
schizophrenia and 244 healthy controls were genotyped for six
TPH2 SNPs ( rs4570625 , rs11178997 , rs11178998 , rs41317118 , rs17110747 , and rs41317114 ) . -
pubmed
Our findings suggest that common genetic variations of
TPH2 are likely to contribute to genetic susceptibility to
paranoid schizophrenia in Han Chinese . -
pubmed
IL-22 gets to the stem of
colorectal cancer . -
pubmed
Cytokines can provide survival and proliferation signals to
cancer cells , thus promoting
tumor progression . -
pubmed
( 2014 ) reveal that
interleukin-22 can also promote " stemness " in
human colorectal cancer via transcription factor
STAT3 - mediated epigenetic regulation of stem cell genes . -
pubmed
The variant rs8048002 T>C in intron 3 of the
MHC2TA gene is associated with risk of developing
acute coronary syndrome . -
pubmed
Recently , an intronic single nucleotide polymorphism ( rs8048002 ) in the MHC class II transactivator gene (
MHC2TA ) was shown to be associated with increased susceptibility to several
inflammatory diseases . -
pubmed
The aim of the present study was to test for an association between this
MHC2TA gene polymorphism and susceptibility to the risk of developing
acute coronary syndromes (
ACS ) in a group of Mexicans patients . -
pubmed
The single nucleotide polymorphism ( rs8048002 ) of the
MHC2TA gene was analyzed by 5 ' exonuclease TaqMan genotyping assays in a group of 452 patients with
ACS and 456 healthy controls . -
pubmed
In summary , our data suggest that the
MHC2TA rs8048002 C>T gene polymorphism plays an important role in the risk of developing
ACS . -
pubmed
Association between serum
osteocalcin levels and
non - alcoholic fatty liver disease in women . -
pubmed
BACKGROUND AND AIMS :
Osteocalcin was found to have a significant role in
insulin resistance . -
pubmed
However , the relationship between serum
osteocalcin level and
NAFLD is not well known . -
pubmed
RESULTS : Serum
osteocalcin level was independently associated with menopausal status , bone mineral density ,
calcium ,
phosphate ,
alkaline phosphatase , fasting blood
glucose ,
triglyceride ,
low - density lipoprotein cholesterol ,
alanine aminotransferase ,
gamma - glutamyltransferase , and
NAFLD . -
pubmed
When women were grouped according to their menopausal status and bone mineral density , the
serum osteocalcin level showed an independent inverse association with
NAFLD in premenopausal women without
osteopenia or
osteoporosis ( n = 2,941 ) [ odd ratio ( OR ): 0.94 , 95 % confidence interval ( CI ): 0.91 - 0.96 , p & lt ; 0.001 ] and postmenopausal women without
osteopenia or
osteoporosis ( n = 2,155 ) ( OR : 0.96 , 95 % CI : 0.95 - 0.98 , p & lt ; 0.001 ) , however , not in premenopausal ( n = 308 ) or postmenopausal women ( n = 1,663 ) with
osteopenia or
osteoporosis . -
pubmed
CONCLUSIONS : The serum
osteocalcin level was an independent factor associated with
NAFLD , especially for women with normal bone mineral density . -
pubmed
Qiliqiangxin Protects Against
Cardiac Ischemia -
Reperfusion Injury via Activation of the
mTOR Pathway . -
pubmed
The determination of serum and urinary
endocan concentrations in
patients with
bladder cancer . -
pubmed
Background Endocan (
endothelial cell - specific molecule-1 ) is a proteoglycan and plays an important role in angiogenesis and
inflammation . -
pubmed
The aim of this study was to evaluate of serum and urinary concentrations of
endothelial cell - specific molecule-1 in
bladder cancer . -
pubmed
Results In
bladder cancer group , serum and urinary
endothelial cell - specific molecule-1 concentrations were significantly higher than in the healthy subjects ( P = 0.003 and P & lt ; 0.0001 ) . -
pubmed
Urinary
endothelial cell - specific molecule-1 concentrations in
cases with
urinary tract infection were higher than in healthy volunteers ( P = 0.002 ) . -
pubmed
There were no significant differences between
bladder cancer and
urinary tract infection groups in terms of serum and urinary
endothelial cell - specific molecule-1 concentrations . -
pubmed
Urinary
endothelial cell - specific molecule-1 concentrations were higher than those of corresponding
serum endothelial cell - specific molecule-1 concentrations ( P & lt ; 0.0001 for
bladder cancer and
urinary tract infection groups , P = 0.002 for healthy subjects ) . -
pubmed
In
bladder cancer group , there was a positive correlation between
serum endothelial cell - specific molecule-1 and urinary
endothelial cell - specific molecule-1 concentrations ( r = 0.32 , P = 0.002 ) . -
pubmed
Conclusion Serum and urinary
endothelial cell - specific molecule-1 concentrations increase in
bladder cancer . -
pubmed
Fetal Anemia and
Hydrops Fetalis Associated with Homozygous Hb Constant Spring (
HBA2 : c.427 T & gt ; C ) . -
pubmed
Hb Constant Spring (
Hb CS ,
HBA2 : c.427 T & gt ; C ) is a common
nondeletional alpha - thalassemia ( alpha - thal ) that results from a
nucleotide substitution at the termination codon of the alpha2 -
globin gene . -
pubmed
Homozygosity for
Hb CS (
alpha ( CS ) alpha / alpha ( CS ) alpha ) is relatively rare , and generally characterized with mild
hemolytic anemia ,
jaundice , and
splenomegaly . -
pubmed
Fetal blood sampling revealed the severe
anemia [
hemoglobin (
Hb ) level being 4.8 g / dL ] and
Hb H ( beta4 ) disease - like hematological findings with
Hb Bart ' s ( gamma4 ) level of 17.9 % . -
pubmed
DNA sequencing of the alpha -
globin genes found that both partners were
Hb CS carriers and the fetus was an Hb CS homozygote . -
pubmed
Functional and genetic screening of
acute myeloid leukemia associated with
mediastinal germ cell tumor identifies
MEK inhibitor as an active clinical agent . -
pubmed
A shared clonal origin was demonstrated through identification of identical
NRAS and
TP53 somatic mutations in both
malignancies . -
pubmed
Glucagon - like peptide-1 receptor agonists in the treatment of
type 2 diabetes : Past , present , and future . -
pubmed
Glucagon - like peptide-1 (
GLP-1)-based therapy improves glycaemic control through multiple mechanisms , with a low risk of
hypoglycaemia and the additional benefit of clinically relevant
weight loss . -
pubmed
Transforming properties of
Felis catus papillomavirus type 2
E6 and
E7 putative oncogenes in vitro and their transcriptional activity in
feline squamous cell carcinoma in vivo . -
pubmed
In addition ,
E6 and
E7 inhibited ultraviolet B ( UVB)-triggered accumulation of
p53 ,
p21 and pro - apoptotic markers such as
Cleaved Caspase3 ,
Bax and
Bak , suggesting a synergistic action of the virus with UV exposure in
tumour pathogenesis . -
pubmed
Importantly , we demonstrated mRNA expression of
FcaPV2 E2 ,
E6 and
E7 in feline
SCC samples , strengthening the hypothesis of a causative role in the development of
feline SCC . -
pubmed
Sphingosine 1 - phosphate receptor 1 is required for retinal ganglion cell survival after
optic nerve trauma . -
pubmed
In this study , we used a classical
optic nerve injury model to address the function of the
sphingosine 1 - phosphate ( S1P )- S1P receptor (
S1PR ) axis in retinal ganglion cell ( RGC ) death and axonal growth . -
pubmed
Moreover ,
retinal infection with
AAV2.shRNA -
S1PR1 down - regulated
mammalian target of rapamycin pathway activation in alphaRGCs . -
pubmed
The role of
sphingosine 1 - phosphate receptor 1 (
S1PR1 ) was studied in retinal ganglion cell survival and axonal growth after
optic nerve injury . -
pubmed
After
axonal damage ,
S1PR1 expression was decreased in retinal neurons . -
pubmed
Synthesis ,
cytotoxicity and
carbonic anhydrase inhibitory activities of new
pyrazolines . -
pubmed
We show that
lysine acetyltransferase 6A (
KAT6A ) is responsible for maintaining permissive Cd8 gene transcription and enabling robust effector responses during
infection . -
pubmed
More precisely , recent studies have shown that
FXR is important for
glucose homeostasis in particular in
metabolic disorders such as
T2D and
obesity . -
pubmed
Anti - cancer activity of
Annexin V in
murine melanoma model by suppressing
tumor angiogenesis . -
pubmed
Annexin V in inhibiting engulfment of apoptotic cells by macrophages had been reported to increase the immunogenicity of
tumor cells undergoing apoptosis . -
pubmed
Treatment with
Annexin V showed significant reduction in
tumor size and remarkable
tumor necrosis areas . -
pubmed
The serum level of
VEGF was downregualted by
Annexin V both in normal
mice and
mice bearing
tumor , suggesting that its new role on impeding
tumor angiogenesis . -
pubmed
In Silico analysis using Oncomine database , we also found the negative correlation of
AnnexinV and
VEGF both in skin and
melanoma . -
pubmed
These data provided a possibility that
Annexin V can be used as a novel angiogenesis inhibitor in
tumor therapy . -
pubmed
Organotypic models of
type III interferon - mediated protection from
Zika virus infections at the maternal - fetal interface . -
pubmed
Here , we developed 3D cell - line - based models of
human syncytiotrophoblasts , cells that lie in direct contact with maternal blood , and show that these cells recapitulate the antiviral properties of primary trophoblasts through the constitutive release of
type III IFNs (
IFNlambda1 and
IFNlambda2 ) and become resistant to
ZIKV infection . -
pubmed
In addition , using organotypic
human midgestation chorionic villous explants , we show that syncytiotrophoblasts isolated from the second trimester of pregnancy also constitutively release
type III IFNs and use these
IFNs in autocrine and paracrine manners to restrict
ZIKV infection . -
pubmed
Collectively , these data provide important insights into the defense mechanisms used by syncytiotrophoblasts at various stages of
human gestation to resist
ZIKV infection and new
human models to study the role of
type III IFNs in the vertical transmission of
ZIKV and other viruses associated with
congenital disease . -
pubmed
Subjects with any form of
uveitis , a positive TB
interferon - gamma release assay or tuberculin skin test , and negative evaluation for other causes of
uveitis were included . -
pubmed
Involvement of
mGluR I in
EphB /
ephrinB reverse signaling activation induced retinal ganglion cell apoptosis in a
rat chronic
hypertension model . -
pubmed
EphB /
ephrinB reverse signaling is involved in retinal ganglion cell ( RGC ) apoptosis in experimental
glaucoma . -
pubmed
Here , we further investigated the mechanisms underlying
EphB /
ephrinB reverse signaling activation induced RGC apoptosis in a
rat chronic ocular hypertension ( COH ) model , using patch - clamp techniques in retinal slices . -
pubmed
Appropriate reduction of
EphB /
ephrinB reverse signaling could alleviate the loss of RGCs in
glaucoma . -
pubmed
Neratinib is a
tyrosine kinase inhibitor that has been approved by the US Food and Drug Administration for the treatment of
breast cancer . -
pubmed
Struggle with Pharmacotherapy for
Underactive Bladder : Could Patients with
Detrusor Underactivity Benefit from
Transient Receptor Potential Vanilloid 4 Agonists ? -
pubmed
Thus , we concluded that
AT1 pathway plays a role in
pulmonary vascular dysfunction by increasing oxidative stress and reducing
NO bioavailability , thereby contributing to vascular remodeling and
pulmonary hypertension of
iron - overload . -
pubmed
Negative correlations were observed pre - PD ( regional CBF in left hippocampus vs. perseverative responses , r = -0.662 , p = 0.014 ) , post - PD ( mean CBF vs.
haemoglobin level , r = -0.766 , p = 0.002 ) , and before and after
PD ( change in CBF in the left putamen vs. change in haematocrit percentage , r = -0.808 , p = 0.001 ) . -
pubmed
,
haemoglobin level or haematocrit percentage , might predict
cognitive impairment in
PD patients . -
pubmed
Value proposition of
PSMA - targeted alpha - particle radioligand therapy in
metastatic prostate cancer . -
pubmed
A
PSA decrease and some reduction of the radiotracer uptake ( SUV ) in
tumor lesions occurred in 60 % and 70 % of the
patients , respectively . -
pubmed
Glucagon - Like Peptide-1 Secretion in Pre -
Diabetes Revisited . -
pubmed
COL1A1 / 2 Pathogenic Variants and Phenotype Characteristics in Ukrainian
Osteogenesis Imperfecta Patients . -
pubmed
Although up to 90 % of patients harbor pathogenic variants in the
COL1A1 / 2 gene , which codes for
collagen alpha1 / 2 chains , the spectrum of
OI genotypes may differ between populations , and there is academic controversy around
OI genotype - phenotype correlations . -
pubmed
OI phenotype severity was highly correlated with type of
collagen I defect . -
pubmed
The current article presents an analysis of the clinical manifestations and
COL1A1 / 2 mutational spectrum of 94 Ukrainian
OI families with 27 novel
COL1A1 / 2 pathogenic variants . -
pubmed
The overall results indicated that
MPS could induce
cytogenotoxicity through the exacerbation of ROS production and inhibition of
cdc2 . -
pubmed
Information on sex , age at first biologic treatment , results of
interferon - gamma release assay ( IGRA ) for
Mycobacterium tuberculosis , treatment history with
isoniazid , and onset of active and/or latent
tuberculosis was collected . -
pubmed
Active
tuberculosis developed in two patients after the administration of
tumor necrosis factor inhibitors ( both involved
miliary tuberculosis ) . -
pubmed
Latent
tuberculosis was observed in two
patients treated with anti -
interleukin-12/
23p40 antibody . -
pubmed
Higher
CCL22 + Cell Infiltration is Associated with Poor Prognosis in
Cervical Cancer Patients . -
pubmed
The
chemokine CCL22 recruits regulatory T ( T - reg ) cells into
tumor tissues and is expressed in many
human tumors . -
pubmed
However , the prognostic role of
CCL22 in
cervical cancer (
CC ) has not been determined . -
pubmed
This study retrospectively analyzed the clinical significance of the expression of
CCL22 and
FOXP3 in 230
cervical cancer patients . -
pubmed
CCL22 was primarily expressed in M2 - like macrophages in
CC and induced by
cervical cancer cells . -
pubmed
The findings of our study indicate that
cervical cancer patients with elevated
CCL22 + infiltrating cells require more aggressive treatment . -
pubmed
A 24 - week study demonstrated that
sodium benzoate , a
D - amino acid oxidase (
DAAO ) inhibitor , surpassed placebo in improving cognitive function in early - phase
Alzheimer ' s disease ; however ,
benzoate did not excel placebo in another 6 - week study on
BPSD . -
pubmed
Finally , enzyme - linked immunosorbent assays revealed that the levels of
annexin A5 ,
neutrophil gelatinase - associated lipocalin (
NGAL ) , and
protein S100 - P were significantly higher in the samples of the first urine from
patients with
AKI than in those from
patients without
AKI . -
pubmed
In conclusion , urinary
annexin A5 ,
NGAL and
protein S100 - P levels are promising biomarkers for early , accurate prediction of
AKI in
preterm infants . -
pubmed
Circular RNA has_circ_0000527 participates in proliferation , invasion and migration of
retinoblastoma cells via miR-646 /
BCL-2 axis . -
pubmed
In conclusion , circ_0000527 could promote the development of
RB by indirectly modulating
BCL-2 via absorbing miR-646 . -
pubmed
HIF-1alpha - dependent miR-424 induction confers
cisplatin resistance on
bladder cancer cells through down - regulation of pro - apoptotic
UNC5B and
SIRT4 . -
pubmed
RESULTS : In this study , we have found for the first time that
cisplatin (
CDDP ) induces the expression of miR-424 in a
HIF-1alpha - dependent manner under normoxia , and miR-424 plays a vital role in the regulation of
CDDP resistance of
bladder cancer cells in vitro . -
pubmed
CDDP - mediated suppression of xenograft
bladder tumor growth was prohibited by the addition of miR-424 , whereas ectopic expression of
UNC5B or
SIRT4 partially restored miR-424 - dependent decrease in
CDDP sensitivity of
bladder cancer 5637 and
T24 cells . -
pubmed
There existed a clear inverse relationship between the expression levels of miR-424 and pro - apoptotic
UNC5B or
SIRT4 in
bladder cancer tissues . -
pubmed
CONCLUSIONS : Collectively , our current results strongly suggest that miR-424 tightly participates in the acquisition / maintenance of
CDDP - resistant phenotype of
bladder cancer cells through down - regulation of its targets
UNC5B and
SIRT4 , and thus combination chemotherapy of
CDDP plus
HIF-1alpha / miR-424 inhibition might have a significant impact on hypoxic as well as normoxic
bladder cancer cells . -
pubmed
Role of
proteinase - activated receptors 1 and 2 in nonsteroidal anti - inflammatory drug
enteropathy . -
pubmed
Proteinase - activated receptors 1 (
PAR1 ) and
PAR2 are involved in the pathophysiology of several
digestive disorders . -
pubmed
This study examines the contribution of
PAR1 and
PAR2 in NSAID - induced
small intestinal injury , and to investigate the underlying mechanisms . -
pubmed
RESULTS :
Indomethacin elicited a significant
intestinal damage , associated with a decrease in blood
hemoglobin and an increase in tissue
MPO ,
MDA and fecal
calprotectin . -
pubmed
CONCLUSIONS :
PAR2 is involved in the pathogenesis of
indomethacin enteropathy , through pro - inflammatory mechanisms and an impairment of the intestinal epithelial barrier . -
pubmed
PAR1 activation and
PAR2 inhibition could represent suitable strategies for the prevention of
NSAID enteropathy . -
pubmed
Preclinical PET imaging with the novel
human antibody 89Zr - DFO -
REGN3504 sensitively detects
PD - L1 expression in
tumors and normal tissues . -
pubmed
BACKGROUND :
Programmed cell death protein 1 /
programmed death - ligand 1 (
PD-1 /
PD - L1 ) blocking antibodies including cemiplimab have generated profound clinical activity across diverse
cancer types . -
pubmed
Tumorous
PD - L1 expression , as assessed by immunohistochemistry ( IHC ) , is an accepted predictive marker of response to therapy in some
cancers . -
pubmed
Epstein - Barr virus - immune complexes in postmortem kidneys from African patients with
Burkitt ' s lymphoma and American patients with and without
lymphoma . -
pubmed
Increased
ornithine decarboxylase activity in kidneys undergoing
hypertrophy in experimental
diabetes . -
pubmed
This was done by measuring the activity of the rate - limiting enzyme in the
polyamine pathway (
ornithine decarboxylase ;
ODC ) in kidneys from control ,
diabetic and
insulin - treated
diabetic animals . -
pubmed
The
ODC activity in the kidney was increased in the
diabetic animals with a maximal rise 24 h after
diabetes induction ( 6 - fold , P less than 0.01 ) ; the activity thereafter declined . -
pubmed
In
insulin - treated
diabetic animals the kidney
ODC activity was only increased 3 - fold ( P less than 0.05 ) after 24 h , and for the rest of the study period the activity was about 1.8 - fold higher than in control
rats . -
pubmed
After 14 days the kidneys from
diabetic rats were significantly larger than kidneys from both control and
insulin - treated
diabetic rats , 1066 + /- 43 mg vs. 904 + /- 16 mg and 959 + /- 36 mg , respectively ( P less than 0.01 ) . -
pubmed
However , in muscle from
diabetic animals the
ODC activity declined steadily during the 14 days to 34 % of control values ( P less than 0.01 ) , and
insulin treatment completely normalized the
ODC activity in muscle. -
pubmed
However , in the
rat optic nerve
PDGF levels increased after
axonal injury , whereas in the fish
optic nerve injury was accompanied by an apparent decrease in
PDGF - like levels . -
pubmed
These findings indicate that the
CD4 + Th defect seen in the majority of asymptomatic ,
HIV+
individuals is not limited to recall
antigens , but also extends to the component of the response to
HLA alloantigens that involves the self - restricted ,
CD4 + Th pathway . -
pubmed
Thus , the
Th defect observed in asymptomatic ,
HIV+ patients does not involve a
CD4 + Th defect per se , but is limited to the
HLA self - restricted component of Th function . -
pubmed
Such a reduction in the
TH / S ratio and in the number of circulating suppressor cells was not found in
esophagitis due to either
HSV or
Candida and was unrelated to the serum
cyclosporine level or
prednisone dosage prescribed. -
pubmed
The
cytochrome P450 - dependent enzyme
aminopyrine N - demethylase , consistently depressed in hepatocarcinogenesis models in
mouse and
rat , does not show a significant change among normal , preneoplastic and
neoplastic mammary tissues . -
pubmed
glutathione - S - transferases and
gamma - glutamyl transferase ) , active in the detoxification of xenobiotics , show no significant differences in carcinogen - induced
tumors or in their homologous
preneoplasias compared to control tissue . -
pubmed
There is no increase in the anionic
glutathione - S - transferase , a principal marker in
rat hepatocarcinogenesis . -
pubmed
All
patients presented with typical
hyperpigmentation of the skin and had abnormally raised plasma
ACTH levels . -
pubmed
Trans - sphenoidal microsurgical removal of Nelson 's
ACTH adenomas were successful in seven of ten
patients . -
pubmed
Susceptibility of astrocytes to
class I MHC antigen - specific
cytotoxicity . -
pubmed
We demonstrate that
mouse astrocytes in vitro can be susceptible targets of
class I major histocompatibility complex (
MHC)-specific
cytotoxicity mediated by L3 cytotoxic T lymphocytes ( CTL ) . -
pubmed
Ornithine decarboxylase and
diamine oxidase activities showed maximal increases at 24 h in the striatum of the lesioned side , whereas in the substantia nigra
ornithine decarboxylase attained a very high value as early as 4 h after the operation and
diamine oxidase activity peaked at 48 h. The
enzyme activities returned toward the basal values at 168 h. On the intact side ,
ornithine decarboxylase showed a small increase starting at 4 h and
diamine oxidase was enhanced at 48 h. These results indicate that the stimulation of biosynthetic and degradative enzymes of
polyamine metabolism accompanied by marked and prolonged increases in
putrescine may be essential events in the early phases of neuronal response to
mechanical injury in the CNS . -
pubmed
HMG - CoA reductase inhibitors for treatment of
hypercholesterolemia . -
pubmed
[
Asparaginase for
acute leukemia resistant to various chemotherapies ] . -
pubmed
Production of
interferon and other
lymphokines during
murine tumour growth . -
pubmed
Lymphokines in cell -- free fluid of
rat Zajdela ascites
hepatoma . -
pubmed
Cell - free ascites of
rat Zajdela hepatoma was assayed for the presence of
lymphokine - like factors . -
pubmed
Macrophage migration inhibitory and microbial growth inhibitory
cytokines were detected with peak activities at day 4 - 8 and 10 - 11 after
tumour inoculation , respectively . -
pubmed
In
CHE cells , which possess telomeric repeats at both the terminal and interstitial regions , 39 % of the aberrations induced by
AluI and
PvuII showed telomeric repeat signals . -
pubmed
Six
patients with chronic refractory
autoimmune thrombocytopenic purpura (
ATP ) were treated with five doses of autologous red blood cells ( RBCs ) opsonized ex vivo with
anti - RhO -( D ) IgG. -
pubmed
Three hundred and thirteen cases of
human thyroid tissues , comprising 39
nodular goiters from 34 females and 5 males , 130
adenomas from 93 females and 37 males , and 144
carcinomas from 99 females and 45 males were used for the present immunohistochemical assessment of
estrogen receptor (
ER ) expression . -
pubmed
It was thus suggested that
ER expression may be related to prognosis and
tumor growth at early stage . -
pubmed
Since the incidence of
ER does not significantly differ between females and males , the observed sex differences regarding
thyroid tumor incidence may reflect the higher
estrogen serum content in females . -
pubmed
Corticotropin - releasing factor up - regulates its own receptor gene expression in corticotropic
adenoma cells in vitro . -
pubmed
Patients with
NIDDM had
leptin concentrations similar to controls of similar weight . -
pubmed
Importantly , serum levels of
sTNF alpha - R55 were also positively and independently associated with
leptin in this group of
diabetic subjects and matched controls . -
pubmed
Further elucidation of a possible role of the
TNF alpha system in
leptin expression and circulating levels may have important implications for our understanding of
obesity and
cachexia in
humans . -
pubmed
Crucial role of
interleukin-10 /
interleukin-12 balance in the regulation of the
type 2 T helper cytokine response in
reactive arthritis . -
pubmed
OBJECTIVE : To investigate whether a predominant type 1 T helper ( Th1 ) or Th2
cytokine pattern is present in the joints of
patients with
reactive arthritis (
ReA ) , and whether the
cytokine pattern can be modulated by
cytokines or
anticytokines . -
pubmed
METHODS : Eleven
patients with
ReA following
infection with either
Chlamydia trachomatis ,
Yersinia enterocolitica , or
Salmonella enteritidis were investigated for the presence of Th1 / Th2
cytokines in the joints . -
pubmed
CONCLUSION : These data indicate that a Th2
cytokine pattern predominates in the joints of
patients with
ReA. -
pubmed
Therefore , the
IL-10 /
IL-12 balance appears to be crucial for regulation of the
cytokine pattern in the joints of
patients with
ReA. -
pubmed
The present data support the clinical use of mature , rather than immature , tumor
Ag - pulsed dendritic cells as
cancer vaccines and identifies
CD40L as a potent stimulus to enhance their in vivo
Ag - presenting capacity . -
pubmed
This investigation was based on the hypothesis that weakly immunogenic ,
breast cancer - associated Ags , the products of mutant or dysregulated genes in the malignant cells , will be expressed in a highly immunogenic form by semiallogeneic
IL-2 - secreting fibroblasts transfected with DNA from
breast cancer cells . -
pubmed
To investigate this question , we transfected
LM mouse fibroblasts (
H-2k ) modified to secrete
IL-2 with genomic DNA from a
breast adenocarcinoma that arose spontaneously in a
C3H / He mouse ( H-2k ) . -
pubmed
Vascular endothelial growth factor (
VEGF ) in
children ,
adolescents and young
adults with
Type 1 diabetes mellitus : relation to glycaemic control and microvascular complications . -
pubmed
AIMS : To evaluate serum levels of
vascular endothelial growth factor (
VEGF ) in a large group of
children ,
adolescents and young
adults with
Type 1 diabetes mellitus to investigate whether increased
VEGF concentrations are associated with long - term glycaemic control and microvascular complications . -
pubmed
RESULTS :
VEGF serum levels were significantly increased in pre - school and pre - pubertal
children with
diabetes as well as in pubertal
patients compared to controls . -
pubmed
VEGF concentrations were markedly increased in
adolescents and young
adults with
microvascular complications compared with both healthy controls and
diabetic patients without
retinopathy or
nephropathy . -
pubmed
In poorly controlled
diabetic children ( HbA1c & gt ; 10 % ) , long - term ( 2 years ) improvement of glycaemic control ( aiming at HbA1c & lt ; 7 % ) resulted in a significant reduction of
VEGF levels . -
pubmed
CONCLUSIONS :
VEGF serum concentrations are increased in prepubertal and pubertal
children with
diabetes . -
pubmed
Severity of
microvascular complications is associated with marked increase of
VEGF concentrations in the serum of these
patients . -
pubmed
We postulate that the early drop - outs in the
olanzapine - treated
parkinsonian group may be attributable to a non - specific effect of the drug as a result of starting at too high a dose , and that the worsening of
parkinsonism following prolonged treatment may have been caused by the drug 's blocking effect on
striatal D2 receptors . -
pubmed
The present expanded battery of immunohistochemical stains is presented on this rare
tumor , including
cytokeratin AE1 /
AE3 ,
CK7 ,
CK20 ,
S100 protein ,
epithelial membrane antigen ,
alpha - smooth muscle actin ,
desmin ,
CD34 ,
CD99 ,
Bcl-2 ,
vimentin ,
estrogen and progesterone receptors , and
Ki-67 . -
pubmed
There was minimal expression of
alpha - smooth muscle actin and negative staining with
S100 protein , with coexpression of
cytokeratins and
vimentin and expression of
estrogen and progesterone receptors , as previously reported in
SCEVs . -
pubmed
The rather high proportion of
patients with elevated baseline
serum tryptase levels necessitates further investigation of a possible association between
mastocytosis and treatment failure of conventionally dosed VIT . -
pubmed
We evaluated not only the levels of platelet
cyclic AMP , but also
cyclic GMP and
nitric oxide synthase (
NOS ) activity in
patients with
PD at baseline and after treatment with
clomipramine and in healthy
volunteers . -
pubmed
Platelet
cyclic AMP was determined by enzymeimmunoassay ,
cyclic GMP by radioimmunoassay and
NOS activity by the conversion of
( 3 ) H - arginine to
( 3 ) H - citruline in 17
PD patients before treatment with
clomipramine , after remission of
panic attacks and in 22 healthy
volunteers . -
pubmed
Northern blot analysis showed that
RCC18 cDNA was highly expressed in
RCC , but no signal could be detected in normal kidney . -
pubmed
We have identified inactive , alternatively spliced
dCK forms in leukemic blasts from
patients with resistant
AML . -
pubmed
Because these
dCK - spliced variants were only detectable in resistant
AML , it was hypothesized that they might play a role in
AraC resistance in vivo . -
pubmed
[
Wilms tumor gene (
WT1 ) as a marker for minimal residual disease in
leukemia ] . -
pubmed
Von Hippel - Lindau disease (
VHL ) was diagnosed exclusively by
VHL - gene analysis . -
pubmed
Chemical inhibitors of
cyclin - dependent kinases (
CDKs ) have a great therapeutic potential against various proliferative and
neurodegenerative disorders . -
pubmed
The
pertussis component of this DTPa vaccine , developed by Glaxo SmithKline , consists of pertussis toxoid , filamentous
haemagglutinin and pertactin . -
pubmed
ADAM 33 : just another
asthma gene or a breakthrough in understanding the origins of
bronchial hyperresponsiveness ? -
pubmed
[ Blood
prothrombin during
radiophosphorus and x - ray therapy of
polycythemia and leukoses ] . -
pubmed
Expression of
mast cell tryptase in pediatric otitis media with
effusion . -
pubmed
OBJECTIVE : To evaluate the possible relationship between
allergy and
otitis media with effusion (
OME ) , we investigated the presence and level of
tryptase , which reflect mast cell activity . -
pubmed
Evidence for
mast cell tryptase presence and degree of activation in the middle ear effusion (
MEE ) were measured by using Western blotting and radioimmunoassay ( RIA ) . -
pubmed
RIA demonstrated that mean
tryptase level was significantly higher in the MEE with
allergy positive than negative . -
pubmed
Bilirubin levels in
G6PD - deficient neonates were somewhat higher compared to
G6PD - normal babies ( 18.8 + /- 2.4 mg / dl [ 321.5 + /- 41 micromol / l ] vs. 15.7 + /- 3.2 mg / dl [ 268.5 + /- 54.7 micromol / l ] ; P & lt ; 0.05 ) . -
pubmed
G6PD activity was significantly lower in
G6PD - deficient group than in the normal group ( 2.1 + /- 0.7 vs. 12.5 + /- 5.0 U / g Hb ; P & lt ; 0.001 ) . -
pubmed
CONCLUSION : This study shows that the incidence of
G6PD deficiency in newborns of Tehran is 2.1 % , which is relatively high , and also
hyperbilirubinemia and
jaundice are approximately 3 - fold higher in
G6PD - deficient group than in the
G6PD - normal group ( 51 % vs. 16 % ) . -
pubmed
Dual biological functions of an
interleukin-1 receptor antagonist -
interleukin-10 fusion protein and its suppressive effects on
joint inflammation . -
pubmed
Thyroid function tests revealed elevated serum
thyroxine and
triiodothyronine as well as low
thyroid stimulating hormone concentrations , confirming the diagnosis of
thyrotoxicosis . -
pubmed
Ventilator - induced
lung injury is reduced in transgenic
mice that overexpress
endothelial nitric oxide synthase . -
pubmed
Because
nitric oxide (
NO ) has been reported to play roles in the pathogenesis of
acute lung injury , the present study explores the effects on VILI of
NO derived from chronically overexpressed
endothelial nitric oxide synthase (
eNOS ) . -
pubmed
Anesthetized
eNOS - transgenic ( Tg ) and wild - type ( WT ) C57BL/6
mice were ventilated at high or low tidal volume ( Vt ; 20 or 7 ml / kg , respectively ) for 4 h. After MV ,
lung damage , including neutrophil infiltration , water leakage , and
cytokine concentration in bronchoalveolar lavage fluid ( BALF ) and plasma , was evaluated . -
pubmed
In conclusion , chronic
eNOS overexpression may protect the lung from
VILI by inhibiting the production of
inflammatory chemokines and
cytokines that are associated with neutrophil infiltration into the air space . -
pubmed
Use of
aromatase inhibitors in
children with
short stature . -
pubmed
The use of
aromatase inhibitors may provide a means to delay skeletal maturation and increase final height in
children with
short stature . -
pubmed
Diminished
TLR function in IECs under the influence of Th2
cytokines may protect the host from excessive
TLR signaling , but likely also impairs the host intestinal innate immune defense and increases IEC susceptibility to
chronic inflammation in response to the intestinal microenvironment . -
pubmed
In response to
EGF , the
sialidase redistributed rapidly to ruffling cell membranes of
squamous carcinoma A431 cells and co - localized with
Rac-1 . -
pubmed
Twelve - week monotherapy with the
DPP-4 inhibitor
vildagliptin improves glycemic control in
subjects with
type 2 diabetes . -
pubmed
UNLABELLED : Inhibition of
dipeptidyl peptidase-4 enhances the activity of incretin hormones , improving glycemic control in
subjects with
type 2 diabetes . -
pubmed
To date , 37 different
uromodulin mutations have been described in patients with
MCKD /
FJHN . -
pubmed
We assessed protein processing in the secretory pathway and could demonstrate that although to different extent , all
uromodulin mutations lead to defective ER to Golgi protein transport , suggesting a common pathogenetic mechanism in
MCKD /
FJHN . -
pubmed
Computed tomography severity index and
C - reactive protein values predicting mortality in emergency and intensive care units for
patients with severe acute
pancreatitis . -
pubmed
Linear backward regression analysis showed that high
CRP values and
respiratory failure on ICU admission correlate with longer ICU stay . -
pubmed
High
CRP ,
renal and respiratory failure , and male gender are associated with longer ICU stay . -
pubmed
By enhancing sperm mitochondrial function ,
uPA may provide sufficient energy for capacitated - spermatozoa to increase their motility and change their motor pattern , which might be one of the therapeutic mechanisms of
uPA on male
infertility . -
pubmed
[ Sequential acupuncture method for treatment of
apoplexy hemiplegia and its effects on plasma
ET-1 and
NO levels ] . -
pubmed
CONCLUSION : The sequential acupuncture method has an obvious therapeutic effect on
apoplexy hemiplegia , and it can decrease plasma
ET-1 level and increase
NO level . -
pubmed
Efferent vagal nerve stimulation induces
tissue inhibitor of metalloproteinase-1 in
myocardial ischemia -
reperfusion injury in
rabbit . -
pubmed
We therefore investigated the effects of electrical stimulation of efferent vagal nerve on myocardial expression and activation of
MMPs and
TIMPs in a
rabbit model of
myocardial ischemia - reperfusion ( I / R ) injury . -
pubmed
Total
MMP-9 protein increased significantly after left
coronary artery occlusion in I / R - VS and I / R to a similar degree compared with VS and sham values . -
pubmed
In conclusion , in a
rabbit model of
myocardial I / R injury , vagal nerve stimulation induced
TIMP-1 expression in cardiomyocytes and reduced active
MMP-9 . -
pubmed
Identification and in vitro expansion of functional antigen - specific
CD25 +
FoxP3 + regulatory T cells in
hepatitis C virus infection . -
pubmed
We report that
HCV - infected patients display increased circulating
FoxP3(+ ) Tregs that are phenotypically and functionally indistinguishable from
FoxP3(+ ) Tregs in uninfected subjects . -
pubmed
In conclusion , functionally active and virus - specific
FoxP3(+ ) Tregs are induced in
HCV infection , thus providing targeted immune regulation in vivo . -
pubmed
DNA - repair genes , including
X - ray repair cross - complementing group 1 (
XRCC1 ) and
xeroderma pigmentosum group D (
XPD ) , may also be implicated in the process of pesticide - related carcinogenesis . -
pubmed
Endothelial barrier protection by
FTY720 under
hyperglycemic condition : involvement of
focal adhesion kinase ,
small GTPases , and adherens junction proteins . -
pubmed
Furthermore ,
FTY720 conditioned the phosphorylation profile of
FAK [ Y397 / Y576 / Y925 ] in
hyperglycemic medium to the same pattern observed in normoglycemic medium . -
pubmed
FTY720 challenge resulted in small GTPase
Rac activation under hyperglycemic conditions , whereas increased
Rho activity in
hyperglycemic medium was restored to the basal level . -
pubmed
These findings strongly suggest the barrier protective effect of
FTY720 on HMVEC monolayers in
hyperglycemic medium via
S1P signaling , further implying the possibility of
FTY720 as a therapeutic agent of
diabetic vascular disorder . -
pubmed
NFAT proteins : emerging roles in
cancer progression . -
pubmed
However , ubiquitous expression of
NFAT isoforms in
mammalian tissues has recently been observed , and a role for these
transcription factors in
human cancer is emerging . -
pubmed
Various
NFAT isoforms are functional in
tumour cells and multiple compartments in the
tumour microenvironment , including fibroblasts , endothelial cells and infiltrating immune cells . -
pubmed
How do
NFAT isoforms regulate the complex interplay between these compartments during
carcinoma progression ? -
pubmed
In addition to elucidating the complex role of
NFATs in
cancer , we face the challenge of targeting this pathway therapeutically . -
pubmed
Kinins are vasoactive peptides that play important roles in cardiovascular homeostasis ,
pain and
inflammation . -
pubmed
The
B2R is considered to mediate many of the acute effects of
kinins while the
B1R is more responsible for chronic responses in
inflammation . -
pubmed
Patients with
dysglycemia related to known or unrecognized
diabetes ,
stress hyperglycemia , or
hypoglycemia in the presence or absence of exogenous
insulin routinely require care during the perioperative period or critical illness . -
pubmed
Amrubicin at a lower - dose with routine prophylactic use of
granulocyte - colony stimulating factor for
relapsed small - cell lung cancer . -
pubmed
To overcome this clinical problem , we investigated whether 35 mg / m(2 ) of
AMR administration with routine prophylactic use of
granulocyte - colony stimulating factor (
G - CSF ) can reduce
myelosuppression , while maintaining efficacy . -
pubmed
CONCLUSIONS : Considering both safety and efficacy , AMR at a dose of 35 mg / m(2 ) with routine prophylactic use of
G - CSF may be more desirable for the treatment of relapsed
SCLC in clinical practice . -
pubmed
CO reduced
acute tubular necrosis , apoptosis ,
tissue factor expression and
P - selectin expression and enhanced proliferative repair as measured by phosphorylation of
retinol binding protein and
histone H3 . -
pubmed
[
Peeling skin disease : the responsibility of
corneodesmosin ] . -
pubmed
Other systemic viruses may cause
hepatic injury that can range from mild and transient elevation of
aminotransferases to acute
hepatitis and occasionally
acute liver failure and
fulminant hepatitis . -
pubmed
Class II - associated invariant chain peptide expression represents a novel parameter for flow cytometric detection of
acute promyelocytic leukemia . -
pubmed
Previously , we showed the clinical and functional impact of
class II - associated invariant chain peptide (
CLIP ) in
acute myeloid leukemia (
AML ) . -
pubmed
This study focuses on the analysis of
CLIP expression on leukemic cells to characterize
HLA - DR - negative AML , including
APL . -
pubmed
We demonstrate exclusive and significant
CLIP expression in all cases of typical and variant
APL , as compared to other
HLA - DR - negative
non - APL - type AML . -
pubmed
Hypoxia promotes
rabbit pulmonary artery smooth muscle cells proliferation through a
15 - LOX-2 product
15 ( S )- hydroxyeicosatetraenoic acid . -
pubmed
We found that
hypoxia enhances
15 - lipoxygenase-2 (
15 - LOX-2 ) expression and stimulates cultured
rabbit PASMCs proliferation . -
pubmed
Hypoxia ( 3 %
O ( 2 ))-stimulated PASMC proliferation was blocked by
U0126 , a
MEK inhibitor , as well as by
NDGA and
CDC , inhibitors of
15 - LOX , but not by the
p38 MAPK inhibitor
SB-202190 . -
pubmed
We conclude that
15 - LOX-2 and its product ,
15 ( S )- HETE , are important intermediates in
hypoxia - induced
rabbit PASMC proliferation and may participate in
hypoxia - induced
pulmonary hypertension . -
pubmed
Paraneoplastic syndrome in
mice bearing high - angiogenic variant of
Lewis lung carcinoma : relations with
tumor derived
VEGF . -
pubmed
CONCLUSION : Manifestation of the
paraneoplastic hematological syndrome most likely is conditioned on the ability of
cancer cell to secrete
VEGF in a high rate . -
pubmed
Helminth antigens enable CpG - activated dendritic cells to inhibit the symptoms of collagen - induced
arthritis through
Foxp3 + regulatory T cells . -
pubmed
Vaccination of
mice with
CII pulsed T / C - DC diminished the severity and incidence of
CIA symptoms and the production of the
inflammatory cytokine , while induced the production of
anti - inflammatory cytokines . -
pubmed
Vaccination with
CII pulsed T / C - DC seems to be a very efficient approach to diminish exacerbated immune response in
CIA , by inducing the development of Treg cells , and it is therefore an interesting candidate for a cell - based therapy for
rheumatoid arthritis (
RA ) . -
pubmed
Conversely , there is emerging evidence that other T cell subsets ( gammadelta , gammadelta ) ,
CD8(+ ) T cells and natural killer ( NK ) cells may play a vital role in immune protection against
Mtb infection and BCG - induced immune protection . -
pubmed
In this paper , the controversy over the role of
IFN - gamma as a marker for protective immunity against
TB , and emerging data on the role of gammadelta T cells ,
CD8(+ ) and NK cells in
TB immunology , will be presented . -
pubmed
In a multivariate
COX analysis age , WHO performance score , subcortical localization , extent of surgery , radiation treatment , chemotherapy , and the presence of large
necrosis had individual effect on overall survival ( p & lt ; 0.05 ) . -
pubmed
BACKGROUND : Although many Asian
type 2 diabetic patients have been considered to be not
obese and have low capacity of
insulin secretion , the proportion of
obese patients with visceral fat accumulation has increased in recent years . -
pubmed
Podoplanin expression in
cancer - associated fibroblasts correlates with
VEGF - C expression in
cancer cells of invasive
ductal breast carcinoma . -
pubmed
Podoplanin (
D2 - 40 ) was shown to be expressed in
cancer - associated fibroblasts ( CAFs ) of various
malignancies . -
pubmed
Podoplanin expression in CAFs correlated positively with
cancer cell
VEGF - C expression ( r=0.19 , p=0.0495 ) and intratumoral microvessel count ( MVC ) of
CD31 positive vessels ( r=0.30 , p=0.0018 ) , whereas negative correlations were observed with peritumoral MVC of D2 - 40 and
Lyve-1 positive lymphatic vessels ( r=-0.26 , p=0.008 and r=-0.27 , p=0.0058 , respectively ) . -
pubmed
Podoplanin expression in CAFs did not correlate with
VEGF - A and
VEGF - D expression in
cancer cells , nor exerted any prognostic significance . -
pubmed
Podoplanin expression in CAFs may have impact on angio- and lymphangiogenesis processes in
IDC . -
pubmed
Activating mutations in
c - Kit lead to alteration of these cellular processes and have been implicated in many
human cancers such as
gastrointestinal stromal tumors ,
acute myeloid leukemia ,
testicular seminomas and
mastocytosis . -
pubmed
[ Changes in
CD4(+)
CD25(+ ) regulatory T cells in
patients with spontaneous
subarachnoid hemorrhage ] . -
pubmed
OBJECTIVE : To explore the role of
CD4(+)
CD25(+ ) regulatory T cells ( Treg ) in the occurrence of spontaneous
subarachnoid hemorrhage (
SAH ) . -
pubmed
METHODS : Fifteen
patients with spontaneous
SAH , 15 with
traumatic SAH , and 15 with
headache without organic pathologies as confirmed by lumbar puncture ( control group ) were examined with flow cytometry for Treg in the peripheral blood and cerebrospinal fluid and intracellular
cytokine interleukin-10 (
IL-10 ) and
transforming growth factor beta1 (
TGF - beta1 ) levels . -
pubmed
RESULTS : Spontaneous
SAH patients showed significantly lowered peripheral blood Treg ,
IL-10 , and
TGF - beta1 in the cerebrospinal fluid compared with the
patients with traumatic
SAH and the control group ( P<0.05 ) , and the 3 measurements were comparable between the latter two groups ( P>0.05 ) . -
pubmed
Correlation analysis showed that Treg ,
IL-10 and
TGF - beta1 were all inversely correlated with NIHSS , VAS , and duration of hospitalization but positively correlated with
GCS ( the absolute r values were all greater than 0.6 , P<0.05 ) . -
pubmed
OBJECTIVE : This study was undertaken in the belief that the atypical antipsychotic drug
quetiapine could prevent apoptosis in the penumbra region following
ischemia , taking into account findings that show
5 - hydroxytryptamine-2 receptor blockers can prevent apoptosis . -
pubmed
DNA MET % was measured as incorporation of
[ ( 3 ) H ] dCTP following
HpaII cut in 96
ALS patients and 87 controls , comprising : early - onset ( < 55 years of age ) and late - onset ( > 74 years of age ) . -
pubmed
In conclusion , increased DNA
MET % is a possible marker of epigenetic dysfunction in
ALS independently of age of onset . -
pubmed
Osteopontin is a promoter for
hepatocellular carcinoma metastasis : a summary of 10 years of studies . -
pubmed
In our previous gene expression profiling study ,
OPN was identified as one of the leading genes associated with the metastasis of
hepatocellular carcinoma (
HCC ) . -
pubmed
We focused on
OPN to evaluate its prognostic values and important roles in
HCC metastasis . -
pubmed
A retrospective study of large cohorts of
HCC patients demonstrated that plasma
OPN level was one of the leading independent prognostic factors for
HCC patients , even in the early stage of
HCC , and could serve as a surrogate serologic biomarker for monitoring the treatment response and
tumor recurrence after
HCC resection . -
pubmed
Using both in vitro and in vivo investigations , we found that
OPN has an important role in metastasis and
tumor growth of
HCC and is an attractive potential therapeutic target for combating
HCC metastasis . -
pubmed
We also found that
OPN+
HCC cells have much more amplifications at chromosomal regions , and promoter polymorphisms are important in the regulation of
OPN expression and
tumor growth and lung metastasis of
HCC . -
pubmed
Electrocardiogram , ultrasonic cardiogram ,
arrhythmia ,
troponin and non - hematologic
toxicity were recorded and compared after the second , forth and sixth cycle of chemotherapy . -
pubmed
The reduction of QRS voltage ,
arrhythmia and abnormal
troponin were 55.0 % , 45.0 % and 45.0 % , respectively , in the control group , significantly higher than those in the experimental group ( 20.0 % , P & lt ; 0.05 ) , ( 10.0 % , P = 0.010 ) and ( 10.0 % , P & lt ; 0.05 ) , respectively . -
pubmed
Treatments addressing both at the same time might have advantages over more specific approaches , such as
vascular endothelial growth factor (
VEGF ) inhibitors , which are used to treat
vascular leak but are suspected to have a
neurotoxic effect . -
pubmed
TA not only prevented the development of
retinal vascular lesions but also inhibited
fluorescein leakage from established
vascular lesions . -
pubmed
Our results corroborate previous findings reporting the involvement of
DRD3 receptor in
addictions . -
pubmed
Successful engraftment of third allogeneic hematopoietic stem cell transplantation after two graft failures and treatment for anti -
HLA antibody in a pediatric acquired
aplastic anemia patient . -
pubmed
Here , we exploit the availability of genome sequences for
Hpa and
Arabidopsis to measure gene - expression changes in both
Hpa and
Arabidopsis simultaneously during
infection . -
pubmed
Using a high - throughput cDNA tag sequencing method , we reveal expression patterns of
Hpa predicted effectors and Arabidopsis genes in compatible and incompatible interactions , and promoter elements associated with
Hpa genes expressed during
infection . -
pubmed
Finally , we found a highly - expressed
Hpa effector candidate that suppresses responsiveness to
SA . -
pubmed
Skin lesions after oral
acetylcholinesterase inhibitor therapy : a case report . -
pubmed
A series of
botulism challenge studies were conducted to determine if
botulinum toxin would be produced in mussels (
Mytilus edulis ) inoculated with non - proteolytic
Clostridium botulinum spores and held under modified atmosphere ( MA ) packaging conditions at normal ( 4 C ) and abusive ( 12 C ) temperatures . -
pubmed
After adjusting for gender , age , systolic blood pressure ,
serum albumin ,
calcium -
phosphorus product ,
hemoglobin A1c , and use of an
angiotensin - converting enzyme inhibitor or an
angiotensin II receptor blocker ,
patients with
nephrotic range
proteinuria showed a 3.89 - fold ( 95 % CI 1.08 - 14.5 ) increased risk for
rapid renal function decline defined as a decline in eGFR & gt;=0.5 ml / min/1.73 m(2 ) per month . -
pubmed
Toll - like receptor 5 deficiency exacerbates
cardiac injury and
inflammation induced by
myocardial ischaemia - reperfusion in the
mouse . -
pubmed
We therefore evaluated the role of
TLR5 , expressed at high level in the heart , in the development of
myocardial damage and
inflammation acutely triggered by
MIR . -
pubmed
TLR5(-/- ) and wild - type ( WT )
mice were exposed to MIR ( 30 min
ischaemia , 2 h reperfusion ) . -
pubmed
Lack of
TLR5 fostered
p38 phosphorylation , reduced
AKT phosphorylation and markedly increased the expression of inflammatory
cytokines , whereas it precipitated
acute LV ( left ventricle ) dysfunction . -
pubmed
Therefore , contrary to the detrimental roles of
TLR2 ,
TLR3 and
TLR4 in the infarcted heart ,
TLR5 is important to limit
myocardial damage ,
inflammation and functional compromise after MIR . -
pubmed
As islet architecture was destroyed with age in ZFDM
rats , a combination of severe
insulin resistance , diminished
insulin secretory response to incretin , and intrinsic fragility of the islets may cause the development of
T2D in this strain . -
pubmed
Re : Ion Channel
TRPM8 Promotes Hypoxic Growth of
Prostate Cancer Cells via an
O2 - Independent and
RACK1 - Mediated Mechanism of
HIF-1alpha Stabilization . -
pubmed
A Potential Role for the Inhibition of
PI3 K Signaling in
Glioblastoma Therapy . -
pubmed
In almost 90 % of all
GBM alterations in the
PI3K /
Akt /
mTOR have been found , making this survival cascade a promising therapeutic target , particular for combination therapy that combines an apoptosis sensitizer , such as a pharmacological inhibitor of
PI3 K , with an apoptosis inducer , such as radio- or chemotherapy . -
pubmed
In this study , we analyze the effects of the dual kinase inhibitor
PI-103 , which blocks
PI3 K and
mTOR activity , on three matched pairs of
GBM stem cells / differentiated cells . -
pubmed
While blocking
PI3K - mediated signaling has a profound effect on cellular proliferation , in contrast to data presented on two
GBM cell lines (
A172 and
U87 )
PI-103 actually counteracts the effect of chemotherapy . -
pubmed
Genetic and epigenetic alterations of
netrin-1 receptors in
gastric cancer with chromosomal instability . -
pubmed
BACKGROUND : The gene expressions of
netrin-1 dependence receptors ,
DCC and
UNC5C , are frequently downregulated in many
cancers . -
pubmed
RESULTS : In the present study , a series of genetic and epigenetic analyses for
DCC and
UNC5C were performed in a Japanese cohort of 98 sporadic
gastric cancers and corresponding
normal gastric mucosa specimens . -
pubmed
More than 5 % methylation in the
DCC and
UNC5C promoters were found in 45 % ( 44/98 ) and 32 % ( 31/98 )
gastric cancers , respectively , and in 9 % ( 9/105 ) and 5 % ( 5/105 )
normal gastric mucosa , respectively . -
pubmed
Overall , 70 % ( 58 of 83 informative cases ) and 51 % ( 40 of 79 informative cases ) of
gastric cancers harbored either LOH or aberrant methylation in the
DCC and
UNC5C genes , respectively . -
pubmed
Both
DCC and
UNC5C were inactivated in 97 % of
CIN - positive gastric cancers and in 55 % of
CIN - negative gastric cancers . -
pubmed
CONCLUSIONS : Defect in
netrin receptors is a common feature in
gastric cancers . -
pubmed
DCC alterations are apparent in the early stages , and
UNC5C alterations escalate with the progression of the disease , suggesting that the cumulative alterations of
netrin-1 receptors was a late event in
gastric cancer progression and emphasizing the importance of this growth regulatory pathway in gastric
carcinogenesis . -
pubmed
We compared T cell recognition of 59 prevalently recognized
Mycobacterium tuberculosis (
MTB ) antigens in individuals latently infected with
MTB (
LTBI ) , and uninfected individuals with previous BCG vaccination , from nine locations and populations with different
HLA distribution , MTB exposure rates , and standards of
TB care . -
pubmed
Targeting
Interleukin-1beta Reduces Leukocyte Production After
Acute Myocardial Infarction . -
pubmed
METHODS AND RESULTS : With the use of parabiosis surgery , this study shows that soluble danger signals , among them
interleukin-1beta , increase bone marrow hematopoietic stem cell proliferation after
MI . -
pubmed
Anti -
interleukin-1beta treatment dampens the post -
MI increase in hematopoietic stem cell proliferation . -
pubmed
Consequently , decreased leukocyte numbers in the blood and
infarct reduce
inflammation and diminish post - MI
heart failure in
ApoE(-/- )
mice with
atherosclerosis . -
pubmed
Prognostic significance of
FAM83D gene expression across human
cancer types . -
pubmed
The family with sequence similarity 83 , member D (
FAM83D ) gene has been proposed as a new prognostic marker for
breast cancer . -
pubmed
Here we further evaluate the prognostic significance of
FAM83D expression in different
breast cancer subtypes using a meta - analysis . -
pubmed
Patients with higher
FAM83D mRNA levels have significantly decreased overall and metastatic relapse - free survival , particularly in the group of patients with
ER - positive , or luminal subtype
tumors . -
pubmed
We also assessed
FAM83D alterations and its prognostic significance across 22 human
cancer types using The Cancer Genome Atlas ( TCGA ) . -
pubmed
FAM83D is frequently gained in the majority of human
cancer types , resulting in the elevated expression of
FAM83D. -
pubmed
Higher levels of
FAM83D mRNA expression are significantly associated with decreased overall survival in several
cancer types . -
pubmed
Finally , we demonstrate that
TP53 mutation in human
cancers is coupled to a significant increase in the expression of
FAM83D , and that a higher level of
FAM83D expression is positively correlated with an increase in genome instability in many
cancer types . -
pubmed
These results identify
FAM83D as a potential novel oncogene across multiple
human cancer types . -
pubmed
Neuroscience - informed Auditory Training in
Schizophrenia : A Final Report of the Effects on Cognition and
Serum Brain - Derived Neurotrophic Factor . -
pubmed
At baseline ,
schizophrenia participants had significantly lower - than - normal serum
BDNF . -
pubmed
FGF23 in
chronic kidney disease : are we lost in translation ? -
pubmed
Flap endonuclease 1 polymorphisms ( rs174538 and rs4246215 ) contribute to an increased
cancer risk : Evidence from a meta - analysis . -
pubmed
Since the identification of functional polymorphisms of
FEN1 ( rs174538 and rs4246215 ) , numerous studies have evaluated the association between the two single - nucleotide polymorphisms and
cancer risk . -
pubmed
To derive a more precise estimation , a meta - analysis was performed on the association between the
FEN1 polymorphisms ( rs174538 and rs4246215 ) and
cancer risk . -
pubmed
The present meta - analysis indicated that
FEN1 rs174538 and rs4246215 polymorphisms may contribute to an increased risk of
cancer . -
pubmed
Expression of different
cytokines and
growth factors after
myocardial injury has been associated with
fibroplasia and dilatation versus reverse remodeling and myocardial repair . -
pubmed
Specifically , the proinflammatory / fibrotic mediators :
interleukin ( IL )- 6 ,
epidermal growth factor , and
fibroblast growth factor ( FGF )- 2 cause
fibroplasia , whereas reparative
cytokines including :
IL-1alpha ,
IL-1beta ,
IL-4 , and
IL-13 can limit
fibrosis . -
pubmed
Donor
CD4(+ ) T and B cells play important roles in
cGVHD pathogenesis , but the role of antibodies from donor B cells remains unclear . -
pubmed
In contrast ,
IgH(microgamma1 ) grafts induced only transient
cGVHD with little damage in the thymus or peripheral lymph organs or with little cutaneous Th17 infiltration . -
pubmed
Injections of
IgG - containing sera from
cGVHD recipients given WT grafts but not
IgG - deficient sera from recipients given IgH(microgamma1 ) grafts led to deposition of
IgG in the thymus and skin , with resulting damage in the thymus and peripheral lymph organs , cutaneous Th17 infiltration , and perpetuation of
cGVHD in recipients given IgH(microgamma1 ) grafts . -
pubmed
These results indicate that
donor B - cell antibodies augment
cutaneous cGVHD in part by damaging the thymus and increasing tissue infiltration of pathogenic Th17 cells . -
pubmed
The regulatory role of
interferon - gamma producing gamma delta T cells via the suppression of T helper 17 cell activity in
bleomycin - induced
pulmonary fibrosis . -
pubmed
Histological and biochemical analyses showed that
bleomycin - induced
IP was more severe in
T cell receptor (
TCR - delta - deficient ( TCRdelta (-/- ) ) mice than WT
mice . -
pubmed
The examination of
IL-17A (-/- ) TCRdelta (-/- ) mice indicated that gammadeltaT cells suppressed
pulmonary fibrosis through the suppression of
IL-17A(+ )
CD4(+ ) T cells . -
pubmed
Pulmonary fibrosis was attenuated by
IFN - gamma - producing gammadeltaT cells through the suppression of pulmonary
IL-17A(+ )
CD4(+ ) T cells . -
pubmed
CD4(+)
CD25(+)
CD127(- ) and
CD4(+)
CD25(+)
Foxp3(+ ) Regulatory T Cell Subsets in Mediating Autoimmune Reactivity in
Systemic Lupus Erythematosus Patients . -
pubmed
Introduction of the
CD4(+)
CD25(+)
CD127(- ) and
CD4(+)
CD25(+)
Foxp3(+ ) regulatory subpopulations analysis into immunological processes assessment and disease activation prognosis in
patients with
lupus nephritis (
LN ) may improve monitoring of disease activity and enable an early , and thus more effective , therapeutic treatment . -
pubmed
IN CONCLUSION : ( 1 ) reduction in the number of regulatory
CD4(+)
CD25(+)
Foxp3(+ ) cells is a promising indicator of the activity of
SLE , particularly of renal involvement ; ( 2 ) determination of the number of regulatory cells using the
CD4(+)
CD25(+)
CD127(- ) phenotype is unreliable in patients with
SLE . -
pubmed
CD40L expression by CD4 + but not CD8 + T cells regulates antiviral immune responses in acute
LCMV infection in
mice . -
pubmed
However , deficiency of
CD40L in CD8 + T cells did influence neither the quantity nor the quality of primary T - cell responses in
LCMV infection . -
pubmed
Thus , our results unambiguously demonstrate that while
CD40L is critical to generate effective primary
CD8 + T - cell responses also under inflammatory conditions ,
CD40L expression by CD8 + T cells themselves is dispensable in acute
LCMV infection . -
pubmed
Compared with
JLPS cells , the increased
glucose uptake in
JLPR cells ( with upregulated
glucose transporters , increased antioxidant enzyme activity , and altered cell cycling ) conferred
ascorbate - induced
cytotoxicity and resistance . -
pubmed
Here we describe the addition of
KSHV proteins LANA and
K8.1 to a previously evaluated
HIV / co - infection multiplexed fluorescence immunoassay system . -
pubmed
These results demonstrate good sensitivity and specificity for detection of
antibody to KSHV antigens , and demonstrate the potential for multiplexed co -
infection testing in resource - limited settings to identify those at increased risk for
HIV-1 - related complications . -
pubmed
In particular , 60
breast cancers with the following four molecular subtypes were analyzed : luminal A , luminal B ,
human epidermal growth factor receptor-2 (
HER2)-over - expressing and basal - like . -
pubmed
These results indicate that
EV Ag delivery via DNA vaccination offers a new strategy for eliciting strong
CD8 + T cell responses to the encoded
Ag , making it a potentially useful
cancer vaccine . -
pubmed
Lecithin : cholesterol acyltransferase (
LCAT ) catalyzes plasma
cholesteryl ester formation and is defective in
familial lecithin : cholesterol acyltransferase deficiency (
FLD ) , an
autosomal recessive disorder characterized by low high - density lipoprotein ,
anemia , and
renal disease . -
pubmed
Eligibility for alirocumab or evolocumab treatment in 1090
hypercholesterolemic patients referred to a regional
cholesterol treatment center with
LDL cholesterol & gt;=70 mg / dL despite maximal - tolerated
LDL -
cholesterol - lowering therapy . -
pubmed
BACKGROUND :
Proprotein convertase subtilisin / kexin type 9 inhibitors ,
Praluent ( alirocumab [ ALI ] ) and Repatha ( evolocumab [ EVO ] ) have been approved as adjuncts to the standard - of - care maximal - tolerated dose ( MTD ) of
low - density lipoprotein cholesterol ( LDLC)-lowering therapy ( LLT ) , statin therapy , in heterozygous ( HeFH ) (
ALI or EVO ) or homozygous ( EVO )
familial hypercholesterolemia , or clinical
atherosclerotic cardiovascular disease (
CVD ) where LDLC lowering is insufficient ( both ) . -
pubmed
Recent findings have shown that the autoantibodies anti -
TIF1gamma , anti -
NXP2 and anti -
HMGCR are associated with
cancers in the course of
myositis . -
pubmed
Effect of
neprilysin inhibition on renal function in
patients with
type 2 diabetes and chronic
heart failure who are receiving target doses of inhibitors of the
renin -
angiotensin system : a secondary analysis of the PARADIGM -
HF trial . -
pubmed
BACKGROUND :
Neprilysin inhibition has favourable effects on experimental
diabetic nephropathy . -
pubmed
We sought to assess the effects of
neprilysin inhibition on the course of renal function in
patients with
type 2 diabetes . -
pubmed
The greater effect of
neprilysin inhibition in
patients with
diabetes could not be explained by the effects of treatment on the course of
heart failure or on HbA1c . -
pubmed
INTERPRETATION : In
patients in whom the
renin -
angiotensin system is already maximally blocked , the addition of
neprilysin inhibition attenuates the effect of
diabetes to accelerate the
deterioration of renal function that occurs in
patients with chronic
heart failure . -
pubmed
YAP plays a central role in organ size control , and its deregulation strongly promotes
cancer initiation and progression . -
pubmed
Here , we report that
YAP induces leukocyte - specific
integrin beta2 (
ITGB2 ) expression in
cancer cells , thereby promoting cell invasion through the endothelium in a manner mimicking leukocytes . -
pubmed
Consistently ,
ITGB2 and
PRDM4 mRNA levels are significantly increased in metastatic
prostate cancer . -
pubmed
GCS secretes the hemolysis toxin (
streptolysin S ,
SLS ) that causes
hemolysis in the host cells . -
pubmed
Berberine Attenuates Macrophages Infiltration in
Intracranial Aneurysms Potentially Through
FAK /
Grp78 /
UPR Axis . -
pubmed
Methods and Results :
Human aneurysm tissues were collected by microsurgical clipping and immunostained for
phospho -
Focal adhesion kinase (
FAK ) and
CD68 + macrophages . -
pubmed
Immunostaining data showed that
BBR inhibited
CD68 + macrophages accumulation in
IAs tissues and suppressed
FAK phosphorylation . -
pubmed
Conclusion :
BBR prevents
IAs formation potentially through inhibiting
FAK phosphorylation and inactivating
UPR pathway in macrophages , which causes less macrophage infiltration and reduced proinflammatory
cytokine release . -
pubmed
The biological indicators of
Qi deficiency related were blood lipids , ECG , blood rheology , inflammatory reaction ,
NO , ET and
NF - kappaB signalling pathway . -
pubmed
These findings indicated that
GBP-1 might play a crucial role in barrier function of normal
human salivary gland duct epithelium and perform a preventive role in the duct epithelium of
IgG4 - RD disease . -
pubmed
Leucocyte esterase strips are available for identifying
leucocyte esterase activity in urine and other body fluids which suggest
inflammation . -
pubmed
Aim : To compare the diagnostic ability of the
leucocyte esterase test between
pyogenic meningitis and CSF contaminated with circulating neutrophils . -
pubmed
Materials and Methods : The CSF samples of
pyogenic meningitis patients were analyzed for
leucocyte esterase activity . -
pubmed
Conclusion :
Leucocyte esterase strip is specific for
pyogenic meningitis ( activated neutrophils ) , and hence can differentiate from CSF contaminated with blood . -
pubmed
MicroRNA-26a reduces
synovial inflammation and
cartilage injury in
osteoarthritis of knee joints through impairing the
NF - kappaB signaling pathway . -
pubmed
Herein , the present study explored the effect of microRNA-26a ( miR-26a ) on the
synovial inflammation and
cartilage injury in
OA , with the involvement with the
NF - kappaB signaling pathway . -
pubmed
Methods :
Rat models of
OA were established by anterior cruciate ligament transection , which were then treated with miR-26a mimics / inhibitors or
BMS-345541 ( inhibitor of
NF - kappaB pathway ) . -
pubmed
Results : Poorly expressed miR-26a and increased protein levels of
P - IkappaBalpha and
P - P65 were identified in synovial tissues of
OA rats . -
pubmed
In response to miR-26a mimics , protein levels of
P - IkappaBalpha and
P - P65 were reduced ; meanwhile ,
synovial tissue hyperplasia ,
inflammation and
cartilage injury of femoral condyle were ameliorated , with decreased
inflammation and
cartilage injury scores , and apoptosis of synoviocytes and chondrocytes . -
pubmed
Conclusion : MiR-26a suppressed the activation of the
NF - kappaB signaling pathway , by which mechanism the
synovial inflammation and
cartilage injury in
OA rats were alleviated . -
pubmed
The role of disordered angiogenesis tissue markers (
sflt-1 ,
Plgf ) in present day diagnosis of
preeclampsia . -
pubmed
According to present data ,
sFlt-1 ,
PlGF and the
sFlt-1 /
PlGF ratio are very useful tools in assessing placental angiogenesis abnormalities associated with
preeclampsia and can be use in clinical practice . -
pubmed
lucidum extracts were then evaluated using SAMP8 and
APP /
PS1 AD model
mice by whole genome
bisulfite sequencing , and some methylation regulators including
Histone H3 ,
DNMT3A , and
DNMT3B in brain tissues were up - regulated after treatment with
alcohol extracts from
G. - pubmed
lucidum
alcohol extracts could improve learning and memory function , ameliorate neuronal apoptosis and
brain atrophy , and down - regulate the expression of the
AD intracellular marker ,
Abeta1 - 42 . -
pubmed
We found a subset of
MDR inhibitors also induced IEC delamination , implicating MDR efflux pumps as cellular targets underlying
Glafenine - induced
enteropathy . -
pubmed
IL-1beta Blockade Attenuates
Thrombosis in a Neutrophil Extracellular Trap - Dependent
Breast Cancer Model . -
pubmed
Interleukin-1beta (
IL-1beta ) modulates the expression of
granulocyte colony - stimulating factor (
G - CSF ) , a
cytokine that promotes
cancer - associated
neutrophilia and NET generation . -
pubmed
Herein , we combined a
murine breast cancer model with a flow - restriction
thrombosis model to evaluate whether the
IL-1beta blockade could interfere with
cancer - associated
thrombosis . -
pubmed
Mice bearing metastatic
4T1 tumors exhibited high neutrophil counts as well as elevated expression of
G - CSF and
IL-1beta in their
tumors . -
pubmed
On the other hand ,
mice bearing non - metastatic
67NR tumors showed no elevation in neutrophil counts and displayed low expression levels of
G - CSF and
IL-1beta in their
tumors . -
pubmed
Pharmacological blockade of
IL-1 receptor (
IL-1R ) decreased the primary growth of
4T1 tumors and reduced the systemic levels of
myeloperoxidase , cell - free DNA ( cfDNA ) and
G - CSF , without interfering with the neutrophil counts . -
pubmed
Most remarkably , the blockade of
IL-1R abolished the prothrombotic state observed in
4T1 tumor - bearing
mice . -
pubmed
Overall , our results demonstrate that
IL-1beta might be a feasible target to attenuate
cancer - associated thrombosis , particularly in
cancer types that rely on increased
G - CSF production and involvement of NET formation . -
pubmed
Accumulated evidence has shown the protective effects of
S1P receptor modulators on
MS and its
animal model ,
experimental autoimmune encephalomyelitis (
EAE ) . -
pubmed
Here we demonstrate that
MAT alleviated astrogliosis in the CNS of
EAE rats , and downregulated levels of
SPH ,
S1P and
S1P1 expression in CNS tissues and astrocytes . -
pubmed
These findings indicate that
MAT could alleviate astrogliosis in
EAE through diminishing the
SPH /
SPHK /
S1P1 pathway . -
pubmed
We aimed to evaluate the effects of the
angiotensin receptor blocker
losartan on gut microbiota in spontaneously
hypertensive rats ( SHR ) , and to test if this modification contributes to its blood pressure ( BP ) reducing properties . -
pubmed
The branched - chain
amino acids (
BCAA ) play an important role in muscle energy metabolism , and
Kruppel - like factor 15 (
KLF15 ) is an essential regulator of
BCAA metabolism in muscle under
nutritional deficiency . -
pubmed
The above results indicated that the regulatory role of
KLF15 in
BCAA catabolism of muscle in
Chinese soft - shelled turtles under
nutritional deficiency , which might be activated the catabolism of
BCAA in muscle to provide energy and maintain the homeostasis by
KLF15 -
BACC signaling axis . -
pubmed
Total follicle diameter , BMI ,
PCOS and
AMH were additional determinants of circulating
prorenin . -
pubmed
CONCLUSIONS : CL number , IVF protocol , BMI ,
PCOS and
AMH affect maternal RAAS activation in early pregnancy , and may thus contribute to pregnancy complications . -
pubmed
IgG4 - related
hypophysitis diagnosed by retroperitoneal mass biopsy in a
patient presenting with
abducens nerve palsy : A case report ( CARE - compliant article ) . -
pubmed
CONCLUSION : Based on the diagnosis of
IgG4 - related disease in the retroperitoneal organ and response to
corticosteroid treatment , this
patient was diagnosed with
IgG4 - related
hypophysitis . -
pubmed
When
IgG4 - related
hypophysitis is suspected , a thorough examination of other organ lesions and biopsy should be considered . -
pubmed
A novel homozygous variant in
REN in a family presenting with classic features of disorders involving the
renin -
angiotensin pathway , without
renal tubular dysgenesis . -
pubmed
Autosomal recessively inherited pathogenic variants in genes associated with the
renin -
angiotensin -
aldosterone system (
RAAS ) result in early onset
oligohydramnios and clinical features of the Potter sequence , typically in association with
proximal renal tubules dysgenesis . -
pubmed
To our knowledge , this is the first identification of an association between biallelic variants in
REN and
oligohydramnios in the absence of
renal tubular dysgenesis . -
pubmed
Due to its role in the RAAS , it has previously been proposed that the decreased expression of
REN results in
hypotension ,
ischemia , and decreased urine production . -
pubmed
We suggest sequencing of genes in the RAAS , including
REN , should be considered in cases of severe early onset
oligohydramnios , even when renal morphology and histology are normal . -
pubmed
Long non - coding RNAs ( lncRNAs ) are considered regulators of autophagy , and the aim of the present study was to investigate the prognostic value of autophagy - related lncRNA (
ARlncRNA ) and develop a new prognostic signature to predict the 1 - year and 3 - year overall survival ( OS ) of
HCC patients . -
pubmed
B7 - H3 - Induced Signaling in
Lung Adenocarcinoma Cell Lines with Divergent
Epidermal Growth Factor Receptor Mutation Patterns . -
pubmed
B7 - H3 - induced signaling includes at least three cascades :
PI3K /
AKT ,
JAK2 /
STAT3 , and
Raf /
MEK /
ERK1 / 2 , which are also involved in
epidermal growth factor receptor- (
EGFR- ) triggered signaling in
lung adenocarcinoma cells . -
pubmed
However , the correlation between
B7 - H3 - induced signaling and
EGFR signaling , and between
B7 - H3 - targeted immunotherapy and
EGFR - targeted therapy in
lung adenocarcinoma , remains to be elucidated . -
pubmed
Herein we find that knockout of
B7 - H3 gene decreased cell survival and increased
EGFR -
tyrosine kinase inhibitor
gefitinib susceptibility of both
H3255 and
HCC827 cells , two
lung adenocarcinoma cell lines harboring
EGFR L858R ( exon 21 ) and Del E746 - A750 ( exon 19 ) mutations , respectively . -
pubmed
Collectively , our study reveals
B7 - H3 - induced signaling in
lung adenocarcinoma cell lines with divergent
EGFR mutations , and a translational potential of combined targeted therapy of
B7 - H3 and
EGFR in
lung adenocarcinoma with
EGFR Del E746 - A750 mutation . -
pubmed
In
Friend leukemia and
NIH 3T3 cells , the levels of
gas5 gene mRNA were high in saturation density - arrested cells and almost undetectable in actively growing cells . -
pubmed
Comparison of spinal fluid
beta 2 - microglobulin levels with
CD4 + T cell count , in vitro T helper cell function , and spinal fluid
IgG parameters in 163 neurologically normal
adults infected with the
human immunodeficiency virus type 1 . -
pubmed
Beta 2 - microglobulin levels were measured in the cerebrospinal fluid ( CSF ) and serum of 163
human immunodeficiency virus - positive (
HIV+ )
persons with normal neurologic physical examinations . -
pubmed
CSF
beta 2 - microglobulin concentration may serve as a marker for subclinical
neurologic damage due to
HIV . -
pubmed
The
thrombus can be lysed and blood flow can be restored with intravenous agents that activate
plasminogen . -
pubmed
Intravenous
rt - PA , a relatively
fibrin - specific agent , elicits recanalization in 70 to 75 per cent of
infarct - related arteries . -
pubmed
Compared with those not so affected ,
hirsutism was associated with a higher mean serum
testosterone concentration ,
infertility was associated with higher mean
gonadotrophin concentrations ,
obesity was associated with a higher mean serum
testosterone concentration ,
hyperprolactinaemia was associated with a lower mean serum
testosterone concentration and smaller ovaries ,
alopecia was associated with lower mean
serum LH and
testosterone concentrations , and
acanthosis nigricans was associated with
obesity and a raised mean serum
testosterone concentration . -
pubmed
coli mutant have provided evidence suggesting an involvement of a
topoisomerase activity in DNA double - strand break mis - repair , which may be relevant to the biochemical defect in
A - T. -
pubmed
A 58 - year - old white
man presented with severe progressive
proximal motor neuropathy , dermato - endocrine changes , and an
IgG kappa paraprotein . -
pubmed
Over a 2 1/2 - year period , treatment with
melphalan and
prednisolone produced improvement in the
neuropathy and resolution of dermato - endocrine features with a corresponding decline in the
serum paraprotein concentration . -
pubmed
These responses and possible reasons for the increased radiosensitivity of
xrs mutants are discussed and compared to
ataxia telangiectasia ( A - T ) cells and a radiosensitive mutant
mouse lymphoma cell line . -
pubmed
The effect of
Ehrlich ascites tumour growth on
lactate dehydrogenase activities in tissues and physiological fluids of
tumour bearing
mice . -
pubmed
In order to investigate the hormone dependency of
gastric cancer , the presence of
estrogen receptor ( E.R. ) -
pubmed
In addition , treatment with this analog abolished the
pituitary hypertrophy and
LH hypersecretion normally associated with castration . -
pubmed
Primary
autoimmune hypothyroidism was confirmed by the finding of a low serum
thyroxine concentration and a high
thyrotropin concentration . -
pubmed
The inhibitor found in this
patient may have been specific for
factor VIII , but the presence of coagulation inhibitors should be considered in
patients with
hypothyroidism . -
pubmed
Serum and blister fluid immune complexes in
bullous pemphigoid : detection with
C1q and
monoclonal rheumatoid factor . -
pubmed
Eighty serum samples and 24 blister fluids from 51
patients with active
bullous pemphigoid were tested for the presence of
immune complexes by both a monoclonal
rheumatoid factor (
mRF ) inhibition radioassay and a
C1q - binding radioassay . -
pubmed
Mechanism of
protein C deficiency in a
patient with
arginine 358 alpha 1 - antitrypsin ( Pittsburgh mutation ): role in the maintenance of hemostatic balance . -
pubmed
In comparison with subjects with good LC , patients with poor LC had higher values of duration of
DM ( p & lt ; 0.01 ) , waist / hip ratio ( p & lt ; 0.04 ) , fasting
glucose ( p & lt ; 0.001 ) and lower values of fasting
insulin ( p & lt ; 0.07 ) ,
LDL cholesterol ( p & lt ; 0.006 ) and
VLDL cholesterol ( p & lt ; 0.09). -
pubmed
These data indicate that endogenous
adenosine inhibits
renin release during
hemorrhagic hypotension , but does not attenuate noradrenergic neurotransmission even during prolonged
hemorrhagic hypotension . -
pubmed
Finally , these experiments indicate that
hemorrhagic hypotension can enhance noradrenergic neurotransmission by a mechanism that does not involve the renal
renin -
angiotensin system . -
pubmed
These results provide strong evidence for an autocrine
IL-8 synthesis and for an
IL-8 - dependent proliferation in a subgroup of
human melanomas . -
pubmed
Furthermore , they suggest that
IL-8 may play a role not only in immunomodulation but also in
melanoma progression and metastatic spread . -
pubmed
A greater production of
beta A4 was observed in
persons with inherited forms of
Alzheimer ' s disease . -
pubmed
The
infection of epithelia ]
swine testicle and
intestinal porcine epithelial ( IPEC-1 ) cell lines by
adenovirus type 5 (
Ad5 ) has been studied in vitro by using an
Ad5 -
luciferase recombinant containing the
firefly luciferase gene as a reporter . -
pubmed
Carboplatin - induced
emesis is observed in about 40 % of
patients despite anti - emetic prophylaxis with
5 - HT3 antagonists . -
pubmed
5 - HT3 receptor antagonists such as
ondansetron seem to be efficacious both in the control of acute and prolonged
emesis following
carboplatin chemotherapy , but randomly controlled data comparing
ondansetron with other anti - emetic regimens have not yet been published . -
pubmed
The induction of
prostaglandin G / H synthase (
PGHS ;
prostaglandin endoperoxide synthase ,
cyclooxygenase ) by proinflammatory
cytokines accounts , at least in part , for the altered
eicosanoid biosynthesis in
inflammatory diseases . -
pubmed
In vivo efficacy and
toxicity of a single - chain immunotoxin targeted to
CD40 . -
pubmed
G28 - 5 sFv - PE40 is a single - chain immunotoxin targeted to
CD40 , which is highly expressed on
human hematologic malignancies , including
non - Hodgkin ' s lymphoma ,
B - lineage leukemias ,
multiple myeloma , and
Hodgkin ' s disease , as well as certain
carcinomas . -
pubmed
In summary ,
G28 - 5 sFv - PE40 was effective at inducing complete antitumor responses in
lymphoma xenografted
mice at doses that were well tolerated in
mice ,
rats , and
monkeys . -
pubmed
Special stains revealed focal intracytoplasmic mucin accumulation , and immunohistochemistry showed the
tumors to be positive for
CAM 5.2 ,
CEA ,
chromogranin A , and
calcitonin . -
pubmed
The three
tumors exhibited positive staining with D07 ( anti -
p53 ) , and flow cytometric analysis revealed DNA aneuploidy and polyploidy . -
pubmed
Further study is necessary to determine whether mutation of the
p53 gene is important in the evolution of
laryngeal neuroendocrine tumors and whether DNA aneuploidy or polyploidy identifies a subset of these
tumors with a poor prognosis . -
pubmed
Role of
tumor necrosis factor alpha in the host response of
mice to
bacteremia caused by
pneumolysin - deficient Streptococcus pneumoniae . -
pubmed
These studies show that the host resistance developed during the first 1 to 2 days after
infection with a pneumolysin - deficient mutant strain is dependent on
tumor necrosis factor alpha but is apparently independent of
interleukin 1beta (
IL-1beta ) or
IL-6 . -
pubmed
The change in protein dynamics detected in these experiments could be the molecular basis for the alteration of
keratin IF organization in
alcoholic hepatitis . -
pubmed
To further corroborate the combination effects of
BAY X 1005 and
dexamethasone the
5 - HT receptor antagonist
methysergide and the
H1 receptor antagonist
pyrilamine were employed as a pretreatment to eliminate
mouse - specific
inflammation responses . -
pubmed
TNF - mediated
cytotoxicity and activation of
caspase-3 were both abrogated in gamma - GCS - overexpressing cells . -
pubmed
Interaction between
insulin resistance and
factor XIII Val34Leu in
patients with
coronary artery disease . -
pubmed
Latent
antithrombin , an inactive antithrombin form with low heparin affinity , has previously been shown to efficiently inhibit angiogenesis and
tumor growth . -
pubmed
CK - MB ,
cTnI and
cTnT were equally efficient for the diagnosis of
acute myocardial infarction , irrespective of the final diagnostic criteria used . -
pubmed
Both
cTnI and cTnT were of equal efficiency in the identification of a high - risk subgroup of
patients with
unstable angina . -
pubmed
Respiratory abnormalities have been described in
MASH-1 (
mammalian achaete - scute homologous gene ) and
c - RET ( " rearranged during transfection " ) mutant newborn
mice . -
pubmed
Genetic polymorphism of the
MxA gene promoter and
interferon responsiveness of
hepatitis C patients : revisited by analyzing two SNP sites ( -123 and -88 ) in vivo and in vitro . -
pubmed
We have previously reported a single
nucleotide polymorphism ( SNP ) at nucleotide ( nt ) position -88 ( G or T ) within an interferon - stimulated response element - like sequence in the promoter region of the
MxA gene , which correlated with responsiveness of
hepatitis C patients to
interferon . -
pubmed
WS type 2 is associated with mutations in the gene encoding
microphthalmia - associated transcription factor (
MITF ) that is required for melanocyte differentiation . -
pubmed
The
MITF - M distal enhancer ( MDE ) , thus identified , contains the binding sites for
SOX10 , a transcription factor responsible for another type of
WS , known as
Waardenburg - Hirschsprung syndrome . -
pubmed
Autonomic regulation of experimental
autoimmune encephalomyelitis : the role of
interferon - gamma . -
pubmed
OBJECTIVE : The effect of chemical sympathectomy on experimental
autoimmune encephalomyelitis (
EAE ) was studied in
interferon - gamma (
IFN - gamma ) knockout C57BL/6
mice . -
pubmed
Unexpectedly , sympathectomy resulted in suppression of active
EAE in
IFN - gamma(-/- )
mice , implying that control of actively induced
EAE by the SNS depends on
INF - gamma and the integrity of the
cytokine network . -
pubmed
Protein expression of
NF - kappaB in
human colorectal
adenocarcinoma . -
pubmed
To clarify the role of
NF - kappaB in
colorectal cancer , we investigated the relationship of
NF - kappaB expression by immunohistochemistry with clinicopathological variables , and other factors including apoptotic index ,
bcl-2 expression ,
p53 and
K - ras mutations in 138 colorectal
adenocarcinomas . -
pubmed
Eighty - seven ( 63 % )
tumours showed cytoplasmic and 51 ( 37 % ) nuclear
NF - kappaB expression . -
pubmed
Nuclear
NF - kappaB was correlated with
mucinous carcinomas ( p=0.006 ) and was more apparent in the invasive margin of some
tumours . -
pubmed
However ,
NF - kappaB was not correlated with gender , age ,
tumour location , Dukes ' stage , survival , apoptotic index ,
bcl-2 expression and
p53 mutations . -
pubmed
Conclusively ,
NF - kappaB might be activated in more aggressive
colorectal tumour cells , since both
tumour cells in the invasive margin and the mucinous
tumour cells could represent more aggressive
tumour cells . -
pubmed
Administration of anti -
interleukin 18 antibody fails to inhibit development of
dermatitis in
atopic dermatitis - model
mice NC / Nga . -
pubmed
Previously we reported that serum
IL-18 levels were elevated in the sera from
atopic dermatitis - model
mice NC / Nga , prior to the onset and during the development of
dermatitis . -
pubmed
OBJECTIVES : We studied whether neutralization of
IL-18 activity might affect
dermatitis in
NC / Nga mice , to investigate the role of
IL-18 on
dermatitis . -
pubmed
METHODS :
NC / Nga mice were given weekly anti -
IL-18 antibody starting at 5 weeks of age to 13 weeks and development of
dermatitis , scratching behaviour and serum
IgE concentrations were evaluated . -
pubmed
RESULTS : Continuous injections of anti -
IL-18 antibody failed to inhibit the onset and development of
dermatitis and
IgE elevation . -
pubmed
In addition , the administration of anti -
IL-18 antibody did not ameliorate the responsiveness of lymphocytes to
IL-4 , which was previously demonstrated as an
immunological abnormality in the
mouse . -
pubmed
CONCLUSION : This study demonstrates that , at least in NC / Nga
mice ,
IL-18 , although excessively expressed before the onset of
dermatitis , shows antiallergic actions . -
pubmed
Immunohistochemical examination of
P - cadherin in bullous and
acantholytic skin diseases . -
pubmed
We examined the expression of
P - cadherin in some
autoimmune bullous skin diseases and
Darier ' s disease using immunohistochemistry and found
P - cadherin to be strongly upregulated . -
pubmed
Influence of
hepatitis C virus infection on soluble cellular
adhesion molecules in hemodialysis
patients . -
pubmed
BACKGROUND / AIMS : Higher levels of soluble cellular
adhesion molecules have been found to be a strong indicator of
endothelial dysfunction and
atherosclerosis in the general population . -
pubmed
We conducted a cross - sectional association study of soluble
cellular adhesion molecules and
hepatitis C in maintenance hemodialysis
patients . -
pubmed
HCV infection was determined as an independent determinant of
sICAM-1 and
sVCAM-1 by multiple linear regression analysis . -
pubmed
AIDS status with
HIV viral load and
CD4 T - cell count were measured at the beginning and at the end of the treatment . -
pubmed
Niemann - Pick disease type C (
NPC ) is a
genetic disorder in which patient cells exhibit lysosomal accumulation of
cholesterol and
sphingolipids ( SLs ) caused by defects in either
NPC1 or
NPC2 proteins . -
pubmed
In the current study , we used protein transduction to further investigate
Rab9 - mediated reduction of stored lipids in
NPC cells . -
pubmed
When
VP22 -
Rab9 was transduced into
NPC1 fibroblasts , nearly all cells showed significant reduction in cellular free
cholesterol levels , with no
cytotoxicity up to 5 microM. -
pubmed
These observations provide important new information about the correction of membrane traffic in
NPC cells by
Rab9 overexpression and may lead to new therapeutic approaches for treatment of this disease . -
pubmed
Effect of inducers of
DT - diaphorase on the haemolytic activity and
nephrotoxicity of
2 - amino-1,4 - naphthoquinone in
rats . -
pubmed
In the present study , the effect of several substances that are known to increase tissue activities of
DT - diaphorase on the
toxicity of
2 - amino-1,4 - naphthoquinone has been investigated . -
pubmed
Again like
2 - hydroxy-1,4 - naphthoquinone , the severity of the
haemolysis induced by the
2 - amino derivative was increased in animals pre - treated with inducers of
DT - diaphorase , but the degree of
nephrotoxicity was decreased . -
pubmed
It is not possible to generalize with regard to the effects of modulation of tissue levels of
DT - diaphorase on
naphthoquinone toxicity in vivo , since this may change not only the severity of the toxic effects , but also the target organ specificity . -
pubmed
In
man ,
renal damage by compounds such as
2 - hydroxy - and
2 - amino-1,4 - naphthoquinone may be a particular problem , because of the low level of
DT - diaphorase in
human liver . -
pubmed
Evidence for a
tumour suppressive function of
APRG1 in
breast cancer . -
pubmed
RESULTS : Levels of
APRG1 mRNA were lower in
malignant tissues . -
pubmed
There was a statistically significant reduction in
APRG1 in grade 3
tumours cf . -
pubmed
APRG1 expression was highly negatively correlated with progressive disease : alive with metastasis ( p = 0.0069 ) , local recurrence ( p = 0.0055 ) , died of
breast cancer ( p = 0.11 ) , all progressive disease ( p = 0.035 ) . -
pubmed
There was also a statistically significant difference in
APRG1 levels between grade 3 and grade 1
tumours . -
pubmed
These results are highly suggestive of
APRG1 acting as a
tumour suppressor gene . -
pubmed
Combined deficiency of factor V and
factor VIII is due to mutations in either
LMAN1 or
MCFD2 . -
pubmed
Mutations in
LMAN1 (
ERGIC-53 ) or
MCFD2 cause combined
deficiency of factor V and factor VIII (
F5F8D ) . -
pubmed
Falsely low
LDL cholesterol results and
cholestasis . -
pubmed
Identification of two new synthetic
histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and
patients with
thalassemia . -
pubmed
Progenitor cells from
patients with
beta ( 0 ) thalassemia generated in vitro morphologically normal proerythroblasts that , unlike normal cells , failed to mature in the presence of
EPO and expressed low
beta - globin levels but 10 times higher - than - normal levels of the
alpha hemoglobin - stabilizing protein (
AHSP ) mRNA . -
pubmed
The low
toxicity exerted by compounds 9 and 24 in all of the assays investigated suggests that these new
HDAC inhibitors should be considered for personalized therapy of selected
patients with beta(0 )
thalassemia . -
pubmed
We and others have previously demonstrated that high
D - glucose induced apoptosis through activation of the
bax - caspase proteases pathway in
human EC and the potential contribution of
hepatocyte growth factor , as an anti - apoptotic factor , to the pathogenesis of
endothelial dysfunction . -
pubmed
Recent work strongly suggests that
NADPH oxidase is a major source of
superoxide in cardiovascular cells , and oxidative stress can be involved in the process of
endothelial dysfunction . -
pubmed
NADPH oxidase can be activated in
hyperglycemia through the
protein kinase C pathway . -
pubmed
From the viewpoint of these molecular mechanisms ,
HMG - CoA reductase inhibitors ( statins ) might inhibit the high
glucose - induced
NADPH oxidase activation through inhibition of
Rac activity and finally prevent the increase in ROS production in
diabetes . -
pubmed
Filaggrin mutations are associated with
ichthyosis vulgaris in the Bangladeshi population . -
pubmed
Histopathological analyses of the antitumor activity of anti -
glypican-3 antibody ( GC33 ) in
human liver cancer xenograft models : The contribution of macrophages . -
pubmed
Previously , we demonstrated the antitumor efficacy of the anti -
glypican-3 (
GPC3 ) antibody GC33 in several
human liver cancer xenograft models and the important role of antibody - dependent cellular
cytotoxicity ( ADCC ) in the antitumor mechanism of GC33 . -
pubmed
In this study , we investigated histopathologically time - course changes in xenografts in
mice following a single administration of GC33 to clarify the morphological changes contributing to the
tumor growth inhibition of GC33 , including the changes in
GPC3 - related factors / components [ proliferation , extracellular matrices ( ECMs ) and macrophage ] . -
pubmed
The results indicate that the
2 - hexyl compound 6f act as the most powerful mechanism - based inactivator of
aromatase among
Delta ( 1 )- AD analogs and may be submitted to the preclinical study in
estrogen - dependent
breast cancer . -
pubmed
It is classically characterized by
tumors in the head and neck region with associated
eosinophilia and elevated serum
immunoglobulin E levels . -
pubmed
T - cell receptor gene rearrangement studies using 2 different techniques did not detect any clonality for
T - cell receptor in both
KD and
MF lesions . -
pubmed
CKS1B nuclear expression is inversely correlated with
p27Kip1 expression and is predictive of an adverse survival in
patients with
multiple myeloma . -
pubmed
We and others have shown that
CKS1B amplification located on chromosome 1q21 is an adverse prognostic factor in
multiple myeloma , but its relationship with
CKS1B nuclear protein expression , is unclear . -
pubmed
The aim of this study was to correlate nuclear
CKS1B protein immunoreactivity , 1q21 amplification status ,
p27 ( Kip1 ) expression and survival in
patients with newly - diagnosed
multiple myeloma . -
pubmed
DESIGN AND METHODS : Nuclear expression of
CKS1B and
p27 ( Kip1 ) was evaluated by immunohistochemistry in decalcified , paraffin - embedded bone marrow biopsies from 94
patients with newly diagnosed
multiple myeloma . -
pubmed
CONCLUSIONS : Immunohistochemistry for
CKS1B is a simple , rapid method that appears to predict 1q21 amplification and adverse outcome for risk stratification of
patients with
multiple myeloma . -
pubmed
The
RET51 /
FKBP52 complex and its involvement in
Parkinson disease . -
pubmed
To clarify if
RET51 /
FKBP52 complex should exert its function in DA neurons , we used an indirect approach by screening the genes encoding for
RET51 and
FKBP52 in a group of 30
Parkinson ' s disease patients . -
pubmed
We found a compound heterozygous carrying two mutations in
RET and
FKBP52 that are sufficient to disrupt the
RET51 /
FKBP52 complex , indicating its potential role in
PD . -
pubmed
CARD15 mutations and perianal fistulating
Crohn ' s disease : correlation and predictive value of antibiotic response . -
pubmed
BACKGROUND :
CARD15 mutations alter bowel immunity and increase susceptibility to
Crohn ' s disease (
CD ) . -
pubmed
AIMS : To assess whether
CARD15 mutations are associated with risk of developing
Crohn ' s perianal fistulas and whether these mutations are predictors of the response of
perianal fistulas to antibiotics . -
pubmed
METHODS :
CARD15 mutations were investigated in 203 consecutive
CD patients . -
pubmed
Patients with history of
perianal fistula were divided into two groups ( with / without
CARD15 mutations ) , and response to antibiotics was evaluated in both groups . -
pubmed
RESULTS : Of the 203 patients , 60 ( 29.6 % ) showed at least one
CARD15 mutation and 55 ( 27.1 % ) had history of
perianal fistula . -
pubmed
Mean age at diagnosis of first
perianal fistula was similar in patients with / without
CARD15 mutations ( 28.7 + - 9.8 versus 29.7 + - 10.1 years , P = 0.758 ) . -
pubmed
Response of
perianal fistulas to antibiotics (
metronidazole alone or combined with
ciprofloxacin ) was significantly higher in patients without
CARD15 mutations ( 7.7 % versus 40.5 % , P = 0.041 ) . -
pubmed
CONCLUSIONS : In
CD ,
CARD15 mutations are not associated with risk of developing
perianal fistulas or with time of their outbreak . -
pubmed
Nevertheless , patients with
perianal fistulas and
CARD15 mutations showed worse response to antibiotics . -
pubmed
This conference report highlights selected presentations on targeting pathological
tau for the prevention or treatment of
Alzheimer ' s disease . -
pubmed
Factor V Leiden mutation ( G1691A ) ( FVL ) is the most common risk factor in
venous thrombosis . -
pubmed
Nephropathy was defined as
microalbuminuria ( urinary
albumin -
creatinine ratio [ ACR ] : 30 to 299 mg / g ) ,
macroalbuminuria ( urinary ACR : & gt;= 300 mg / g ) , or an estimated glomerular filtration rate of & lt;60 mL / min/1.73 m(2 ) . -
pubmed
A positive
tuberculin skin test ( TST ; RR 3.54 , 95%CI 1.13 - 11.11 , P = 0.03 ) and previously healed
TB on chest radiograph ( CXR ; RR 8.71 , 95%CI 1.00 - 75.84 , P = 0.05 ) were significant pre - transplant risk factors for post - transplant
TB on multivariate analysis . -
pubmed
Combination of autoantibodies against different
histone proteins influences complement - dependent phagocytosis of necrotic cell material by polymorphonuclear leukocytes in
systemic lupus erythematosus . -
pubmed
We evaluated the roles of complement , different
antihistone antibodies (
anti - H ab ) , and oxidative burst in the phagocytosis of NC by PMN , as well as association to disease activity and clinical phenotype in
SLE . -
pubmed
METHODS : ELISA and immunoblot were used to measure antibodies to different
histone proteins in sera from
patients with
SLE and
complement - deficient individuals . -
pubmed
RESULTS : A clearly increased phagocytosis of NC was seen in
patients with active
SLE , which was associated with high levels of
anti - H ab concentrations and oxidative burst activity . -
pubmed
CONCLUSION : The distributions of specificities among
anti - H ab are of great importance in the complement - dependent phagocytosis of debris from
NC in
SLE . -
pubmed
Therapeutic options for
bleeding prevention in
FVII deficient patients undergoing surgery comprise various
FVII preparations but the use of
recombinant activated factor VII (
rFVIIa ) seems to be the treatment of choice . -
pubmed
None of our
patients developed excessive
bleeding including those in whom
FVII : C trough levels returned nearly to the baseline level on the first post - op day . -
pubmed
Shh treatment leads to inhibition of
retinoblastoma protein (
pRb ) by increasing phosphorylated
pRb and reducing
retinoblastoma gene transcription . -
pubmed
Mitochondrial neurogastrointestinal encephalopathy (
MNGIE ) is caused by
deficiency in thymidine phosphorylase (
TP ) , that regulates
thymidine (
dThd ) and
deoxyuridine (
dUrd ) . -
pubmed
Expression of
Bcl-2 and the antiapoptotic BAG family proteins in
ovarian cancer . -
pubmed
In
epithelial ovarian cancer (
EOC ) , literature on the prognostic value of
B - cell lymphoma 2 (
Bcl-2 ) is limited and inconsistent . -
pubmed
The major aim of this study was to further define the expression pattern and the prognostic role of
Bcl-2 together with
BAG-1 ,
BAG-3 , and
BAG-4 proteins in
EOC patients receiving
platinum /
taxane - based chemotherapy . -
pubmed
The expression and the prognostic value of
Bcl-2 ,
BAG-1 ,
BAG-3 , and
BAG-4 in
EOC were evaluated by immunohistochemistry and multivariate analysis . -
pubmed
A positive cytoplasmic staining for
Bcl-2 was observed in 23.8 % of
EOC samples and in all histologic subtypes . -
pubmed
BAG-1 ,
BAG-3 , and
BAG-4 were detected in
tumor cell nuclei and cytoplasm . -
pubmed
Expression of
Bcl-2 , or the BAG family proteins , independent of nuclear or cytoplasmic localization , had no significant impact on either
disease - free or overall survival , both in univariate and multivariate survival analyses with the limitation of a small cohort of cases . -
pubmed
In this study , no association between
Bcl-2 expression in
EOC tumor tissue and prognosis was found . -
pubmed
Oral
L - glutamine increases active
GLP-1 ( 7 - 36 )
amide secretion and improves glycemic control in
stretpozotocin -
nicotinamide induced
diabetic rats . -
pubmed
It decreased blood
sugar , stimulated
insulin secretion in
type 2 diabetic patients . -
pubmed
The objective of the present investigation was to evaluate
L - glutamine increases
glucagon like peptide-1 ( GLP-1 ) ( 7 - 36 )
amide secretion in
streptozotocin -
nicotinamide (
STZ -
NTM ) induced
diabetic Sprague Dawley rats . -
pubmed
L - glutamine decreased plasma
glucose , increased plasma and pancreatic
insulin , increased plasma and colonic active
GLP-1 ( 7 - 36 )
amide secretion as well as decreased oxidative stress in
streptozotocin -
nicotinamide induced
diabetic rats . -
pubmed
Synthesis , preclinical validation , dosimetry , and toxicity of 68Ga - NOTA - anti -
HER2 Nanobodies for iPET imaging of
HER2 receptor expression in
cancer . -
pubmed
Biodistribution and PET / CT studies were performed on
HER2 - positive and -negative
tumor xenografts . -
pubmed
Biodistribution studies showed fast and specific uptake ( percentage injected activity [ % IA ] ) in
HER2 - positive
tumors ( 3.13 + - 0.06 and 4.34 + - 0.90 % IA / g for
( 68 ) Ga - NOTA-2Rs15dHis6 and
( 68 ) Ga - NOTA-2Rs15d , respectively , at 1 h after injection ) and high
tumor - to - blood and
tumor - to - muscle ratios at 1 h after injection , resulting in high - contrast PET / CT images with high specific
tumor uptake . -
pubmed
The injected mass showed an effect on the general biodistribution : a 100 - fold increase in
NOTA-2Rs15d mass decreased liver uptake from 7.43 + - 1.89 to 2.90 + - 0.26 % IA / g whereas
tumor uptake increased from 2.49 + - 0.68 to 4.23 + - 0.99 % IA / g. The calculated effective dose , based on extrapolation of
mouse data , was 0.0218 mSv / MBq , which would yield a radiation dose of 4 mSv to a
patient after injection of 185 MBq of
( 68 ) Ga - NOTA-2Rs15d . -
pubmed
Preclinical validation showed high - specific - contrast imaging of
HER2 - positive
tumors with no observed toxicity . -
pubmed
Up - regulation of urinary markers predict outcome in
IgA nephropathy but their predictive value is influenced by treatment with
steroids and
azathioprine . -
pubmed
OBJECTIVE :
Steroids and immunosuppressants can delay progression of renal function in
IgAN , but their possible effect in local
cytokines has not been studied . -
pubmed
Serum
creatinine at time of diagnosis had significant correlation with
proteinuria ( p = 0.02 ) , urinary levels of
IL-1beta ( p = 0.03 ) ,
IL-2 ( p = 0.01 ) and
MCP-1 ( p = 0.03 ) . -
pubmed
Most of the measured
cytokines in the urine predicted
deterioration of renal function in Group A , but the urinary excretion of
IL-6 seemed to predict renal function outcome in both groups of
patients . -
pubmed
CONCLUSION : Several
cytokines are excreted in the urine of
patients with
IgAN , and their levels predict the outcome of the disease . -
pubmed
Our results suggest that
Nrf2 probably inhibits
RANKL - induced OC differentiation by regulating the cellular redox status by controlling the expression of oxidative response genes , findings that might form the basis of a new strategy for treating
inflammatory bone diseases . -
pubmed
Increased
immunoglobulin ( Ig ) G4 - positive plasma cell density and
IgG4 /
IgG ratio are not specific for
IgG4 - related disease in the skin . -
pubmed
OBJECTIVES :
Immunoglobulin ( Ig ) G4 - related disease (
IgG4 - RD ) , a
fibroinflammatory condition that can affect multiple organs , is suggested by
lymphoplasmacytic inflammation ,
fibrosis ,
phlebitis , and increased
IgG4 + plasma cell ( PC ) tissue density . -
pubmed
We aimed to determine whether increased cutaneous
IgG4 + PCs or
IgG4 /
IgG ratio is specific for
IgG4 - RD . -
pubmed
METHODS : We examined 50 mucocutaneous specimens representing seven
PC - rich dermatoses and reactive PC - rich infiltrates with
IgG and
IgG4 immunohistochemical stains . -
pubmed
The
M3 and
M2 muscarinic acetylcholine receptors ( mAChRs ) and
beta-2 - adrenoceptors (
beta2ARs ) are important regulators of airway cell function , and drugs targeting these receptors are among the first line drugs in the treatment of the
obstructive lung diseases asthma and
chronic obstructive lung disease (
COPD ) . -
pubmed
We conclude by discussing how recent advances in
GPCR pharmacology offer a unique opportunity to fine tune
mAChR and
beta2AR signaling and their crosstalk , and thereby produce superior therapeutics for
obstructive lung and other diseases . -
pubmed
Results showed that the
retinoic acid receptor alpha (
RARalpha ) , a target protein in
acute promyelocytic leukemia (
APL ) , was in the top rank , with a pharmacophore model matching well the molecular features of
Tanshinone IIA . -
pubmed
These results indicated that
RARalpha may be a potential target of
Tanshinone IIA for
APL . -
pubmed
Oral administration of
carvedilol at a dose level of 1 and 10 mg / kg daily for 4 weeks resulted in nephroprotective effect as evident by significant decrease in serum
creatinine level , urinary
albumin /
creatinine ratio , and kidney index as well as renal levels of
malondialdehyde ,
nitric oxide ,
tumor necrosis factor - alpha , and
cyclooxygenase-2 with a concurrent increase in
creatinine clearance and renal reduced
glutathione level compared to
diabetic untreated
rats . -
pubmed
Anti -
aquaporin-4 autoantibodies in
systemic lupus erythematosus persist for years and induce astrocytic
cytotoxicity but not
CNS disease . -
pubmed
Anti -
aquaporin-4 autoantibodies are specific for the
neuromyelitis optica spectrum disorders (
NMOSD ) and they have also been described in
patients with
systemic lupus erythematosus (
SLE ) with neurological signs consistent with
NMOSD . -
pubmed
Our objective was to test for the presence and pathogenicity of anti -
AQP4 antibodies in
SLE patients without
neurological disease . -
pubmed
Sera from 89 non - CNS -
SLE patients were screened for anti -
AQP4 autoantibodies . -
pubmed
An in vitro
cytotoxicity assay showed that either sera or purified
IgG from these
patients induced a complement - mediated damage in cultured astrocytes comparable to antibodies obtained from typical
NMO patients . -
pubmed
We conclude that
AQP4 - antibodies can be present in
SLE patients and persist for many years , without concurrent clinical or radiological
NMOSD signs . -
pubmed
It is unclear why the anti -
AQP4 antibodies did not induce
CNS disease . -
pubmed
Although the clinical situation and the blood
haemoglobin concentration are the key factors considered in this rapid decision - making context , laboratory markers should not be based on a single haematocrit value , as its sensitivity to significant
bleeding may be very low . -
pubmed
Serum
lactate and base deficit are very sensitive markers for detecting and monitoring the extent of
bleeding and
shock , in conjunction with repeated combined measurements of
prothrombin time , activated partial
thromboplastin time ,
fibrinogen and platelets . -
pubmed
Since the almost complete absence of
dystrophin is the underlying cause for
X - linked muscular dystrophy , a more detailed understanding of the composition , structure and plasticity of the
dystrophin complexome may have considerable biomedical implications . -
pubmed
Two Chitotriose - Specific
Lectins Show Anti - Angiogenesis , Induces
Caspase-9 - Mediated Apoptosis and Early Arrest of
Pancreatic Tumor Cell Cycle . -
pubmed
The growth inhibitory effect of these
lectins on
pancreatic cancer cells were shown to be a consequence of
lectin cell surface binding and triggering G0 / G1 arrest , mitochondrial membrane depolarization , sustained increase of the intracellular
calcium release and the apoptotic signal is amplified by activation of
caspases executing cell death . -
pubmed
Therefore , we report for the first time two chito - specific lectins specifically binding to tumor glycans ; they can be considered to be a class of molecules with antitumor activity against
pancreatic cancer cells mediated through
caspase dependent mitochondrial apoptotic pathway . -
pubmed
IgG4 - related disease is the term used to refer to a condition characterized by a lymphoplasmacytic infiltrate ,
fibrosis and an increased number of
IgG4 + cells present in tissue , in most cases , with an elevated serum
IgG4 level . -
pubmed
OBJECTIVES : Controversy exists about the integration of
erlotinib in
patients with
EGFR wildtype , advanced
NSCLC . -
pubmed
Cancer stem cell marker
CD90 inhibits
ovarian cancer formation via
beta3 integrin . -
pubmed
CD90 , one of the characterized markers in liver and
gastric cancer , is shown to promote
cancer formation . -
pubmed
However , the underexpression level of
CD90 in
ovarian cancer cells and the evidence supporting the cellular mechanism have not been investigated . -
pubmed
In the present study , we found that the DNA copy number of
CD90 is correlated with mRNA expression in
ovarian cancer tissue and the
ovarian cancer patients with higher
CD90 have good prognosis compared to the
patients with lower
CD90 . -
pubmed
Although the expression of
CD90 in
human ovarian cancer SKOV3 cells enhances the cell proliferation by
MTT and anchorage - dependent growth assay ,
CD90 inhibits the anchorage - independent growth ability in vitro and
tumor formation in vivo . -
pubmed
Our results provide evidence that
CD90 mediates the antitumor formation by interacting with
beta3 integrin , which provides new insight that can potentially be applied in the development of therapeutic strategies in
ovarian cancer . -
pubmed
MTI was defined by a positive
interferon - gamma release assay . -
pubmed
We present a case of a 66 - year - old lady with
chest pain , without dynamic 12 - lead electrocardiographic ( ECG ) changes and normal serial
troponin . -
pubmed
CONCLUSIONS : These results showed that the
human heart expresses the
TH biosynthesis machinery , being altered its main enzymatic system in
patients with
ICM . -
pubmed
Given the relevance of
TH in cardiac pathology , our results provide a foundation for new therapeutic approaches based on
TPO for treating
ICM . -
pubmed
ASK1 (
MAP3K5 ) is transcriptionally upregulated by
E2F1 in adipose tissue in
obesity , molecularly defining a
human dys - metabolic obese phenotype . -
pubmed
We hypothesized that a transcriptional AT stress - signaling cascade involving
E2F1 and
ASK1 (
MAP3K5 ) molecularly defines high - risk
obese subtype . -
pubmed
METHODS :
ASK1 expression in
human AT biopsies was determined by real - time PCR analysis , and chromatin immunoprecipitation ( ChIP ) adopted to AT explants was used to evaluate the binding of
E2F1 to the
ASK1 promoter . -
pubmed
RESULTS :
Human visceral - AT
ASK1 mRNA ( N = 436 ) was associated with parameters of
obesity - related cardio - metabolic morbidity . -
pubmed
Adjustment for
E2F1 expression attenuated the association of
ASK1 with fasting
glucose ,
insulin resistance , circulating
IL-6 , and lipids (
triglycerides ,
HDL -
cholesterol ) , even after adjusting for BMI . -
pubmed
CONCLUSIONS : AT
E2F1 -
ASK1 molecularly defines a metabolically - detrimental
obese sub - phenotype . -
pubmed
Interleukin-1 receptor - associated kinase 1 correlates with metastasis and invasion in
endometrial carcinoma . -
pubmed
Previous studies have investigated the altered expression of
interleukin-1 receptor - associated kinase 1 (
IRAK1 ) in various
cancers . -
pubmed
We aimed at exploring the biological function and the underlying molecular mechanism of
IRAK1 in
EC . -
pubmed
In this study ,
IRAK1 was found elevated in
EC compared with
normal tissues . -
pubmed
Further , high
IRAK1 expression level was correlated with higher
tumor stage , lymph node metastasis , myometrial invasion , and lower survival rate . -
pubmed
Knockdown of
IRAK1 in two
EC cell lines ,
HEC-1 - B and
JEC , significantly inhibited cell proliferation in vitro and in vivo . -
pubmed
We also found that down - regulation of
IRAK1 in
EC cells notably induced cell cycle arrest and apoptois , and also inhibited cell migration and invasion . -
pubmed
Gene set enrichment analysis on The Cancer Genome Atlas dataset showed that Kyoto Encyclopedia of Genes and Genomes ( KEGG ) mitotic cell cycle and cell division pathways were correlative with the
IRAK1 expression , which was further confirmed in
EC cells by Western blot . -
pubmed
These collective data indicated that
IRAK1 overexpression promotes
EC tumorigenesis by activating mitotic cell cycle and cell division pathways , and
IRAK1 may serve as a promising therapeutic strategy for
EC . -
pubmed
There is now ample evidence for a role of
IL-18 in various infectious , metabolic or
inflammatory diseases such as
influenza virus infection ,
atheroma ,
myocardial infarction ,
chronic obstructive pulmonary disease , or
Crohn ' s disease . -
pubmed
However ,
IL-18 plays a very specific role in the pathogenesis of
hemophagocytic syndromes (
HS ) also termed
Macrophage Activation Syndrome . -
pubmed
HS is treated with the
IL-1 Receptor antagonist ( anakinra ) but also specifically with
IL-18BP . -
pubmed
Systemic juvenile idiopathic arthritis or adult - onset Still 's disease are also characterized by high serum
IL-18 concentrations and are treated by
IL-18BP . -
pubmed
Moreover , the protein expression levels of
tumor necrosis factor alpha (
TNF - alpha ) and the
Bcl-2 - associated X protein (
Bax)/
b cell leukemia / lymphoma 2 protein (
Bcl-2 ) ratio were significantly lower at
brain injury sites in
mice of group MG than those of group PBS . -
pubmed
A number of different genes have been shown to be associated with cases of
tooth agenesis including
AXIN2 ,
IRF6 ,
FGFR1 ,
MSX1 ,
PAX9 , and
TGFA . -
pubmed
Wingless / integration signaling gene ,
AXIN2 , is linked to
tooth agenesis and also to
colorectal cancer (
CRC ) . -
pubmed
HmTSP expression in
polyps was restricted to the hypostomal tip and tentacle bases that harbor
Wnt - regulated organizer tissues . -
pubmed
The serum samples were tested for the presence of antibodies against
outer membrane porin C ( anti -
OmpC ) ,
Pseudomonas fluorescens bacterial sequence I2 (
anti - I2 ) , anti - laminarin ( anti - L ) , anti - chitin ( anti - C ) , anti - chitobioside
carbohydrate antibody (
ACCA ) , anti - laminaribioside
carbohydrate antibody (
ALCA ) , anti - mannobioside
carbohydrate antibody ( AMCA ) , and anti -
Saccharomyces cerevisiae antibody (
ASCA ) by indirect enzyme - linked immunosorbent assay ( ELISA).Individually ,
anti - C ,
anti - L ,
ASCA - IgG , and
ALCA lacked diagnostic value in the differentiation of
CD . -
pubmed
ASCA - IgA remained the most accurate marker for the diagnosis of
CD , with an area under the curve ( AUC ) of 0.77 ; however , its sensitivity and specificity were both lower than 75 % . -
pubmed
Among the combinations of the 5 markers with significant diagnosing ability for
CD , combinations with any 2 of the 3 markers ,
ASCA IgA ,
AMCA , and
ACCA positive , provided the best accuracy in the diagnosis and differential diagnosis of
CD ( sensitivity and specificity both above 75 % ) and had the highest Youden index . -
pubmed
For testicular development in
cyp17a1 - deficient fish , a gradually increasing number of spermatozoa and
testis hypertrophy from 3 to 6 mpf were observed , accompanied by constitutively upregulated pituitary
gonadotropin FSH subunit beta (
fshbeta ) . -
pubmed
The
hypertrophic testis and enhanced spermatogenesis in the
cyp17a1 - deficient fish at 6 mpf could be effectively rescued by
fshbeta depletion . -
pubmed
On the other hand , the
hydroxyls groups available on MSNs surface allows the conjugation of specific molecules which can binds to the overexpressed
Enhanced Growth Factor Receptor (
EGFR ) in many
tumors , representing a potential strategy for the
cancer treatment . -
pubmed
Here , we report a case of
IgG4 - related
RPF remission that was only coronary arterial involvement after treatment . -
pubmed
CXCR5 + T CD8 + T - cells play an important role in the control of
viral infections and
tumors . -
pubmed
HIV infection did not affect the frequencies of
CXCR5 +
CD8 + T - cells in secondary lymphoid organs . -
pubmed
Alterations in
DNase activity have been implicated as the cause of various
cancers and
autoimmune diseases . -
pubmed
However , histological evidence of
lung injury (
Lung Injury Score mean difference -0.07 , p = 0.04 ) and BAL
IL-8 were reduced . -
pubmed
Therapeutic effects of
IkB kinase inhibitor during
systemic inflammation . -
pubmed
Animal models of
inflammatory diseases support the idea that
nuclear factor kappaB (
NF - kappaB ) activation plays a pathophysiological role and is widely implicated in
multiple organ dysfunction (
MOD ) . -
pubmed
Indeed , the inhibition of the
IkappaB kinase (
IKK ) complex , involved in the
NF - kappaB pathway , can represent a promising approach to prevent
MOD . -
pubmed
The present work employed a
rat model of
systemic inflammation to investigate the preventive effects of Inhibitor of
IKK complex (
IKK16 ) . -
pubmed
The present study provides convincing evidence that selective inhibition of the
IkappaB kinase complex through the action of
IKK16 , plays a protective role against LPS - induced
multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure . -
pubmed
The aim of our study is to assess the diagnostic performance of the test to detect the
placental alpha microglobulin 1 (
PAMG-1 ) for the prediction of delivery within 7 days in
women with
TPD . -
pubmed
This review presents the cardiovascular and metabolic benefits of
GLP-1 RAs versus placebo , in
patients with
type 2 diabetes . -
pubmed
However , the international guidelines recommend using
GLP-1 RAs as first - line therapy in
type 2 diabetes patients with high cardiovascular risk or as first - line agents in
patients intolerant to
metformin . -
pubmed
Results : The percentages of
patients with high
HA levels in menopause and non - menopause patientswere 55.7 % and 40.5 % , respectively ; in
progesterone receptor ( PR ) positive and negative
patients were 54.1 % and 43.2 % , respectively ; in
estrogen receptor ( ER ) positive and negative
patients were 45.7 % and 60.7 % , respectively ; in
Ki-67 positive and negative
patients were 55.6 % and 43.2 % , respectively ; in the
tumor size stage TI , TII , TIII , and TIV
patients were 50.0 % , 41.7 % , 72.7 % , and 1/1 , respectively ; in lymph node metastasis and
non - metastasispatients were 45.7 % and 53.8 % , respectively . -
pubmed
There was no significant correlation between the level of
HA and the menopausal status , the expressions of
PR ,
ER and
Ki-67 ,
tumor size , and lymph node metastasis in
breast cancer patients ( chi2=2.128 , 1.086 , 1.800 , 1.485 , 4.273 , 0.656 , P>0.05 ) . -
pubmed
Patients with high
HA levels accounted for 30.9 % of
patients aged 52 years or less and 74.4 % of
patients older than 52 years ( chi2=18.274 , P=0.000 ) ; 43.4 % of
patients with early
TNM and 72.7 % of
patients with advanced TNM ( chi2=5.861 , P=0.015 ) ; 45.2 % of
patients without distant metastasis and 78.6 % of
patients with distant metastasis ( chi2=5.333 , P=0.023 ) ; 38.1 % of
Her-2 negative patients and 58.9 % of
Her-2 positive
patients(chi2=4.167 , P=0.041 ) ; and the median survival of
patients with high
HA levels was 70 months , which was shorter than 83 months for
patients with low
HA levels ( chi2=6.799 , P=0.007 ) . -
pubmed
Therefore , ahigh HA content predicts an older age , a later
tumor stage , higher risk of distant metastasis , positive expression of
Her-2 and shorter survival . -
pubmed
Conclusion : The high level of preoperative
serum HA has a certain correlation with the poor prognosis of
breast cancer patients . -
pubmed
CONCLUSION :
Troponin I showed the best diagnostic performance for predicting
cardiac injury in
patients with
CO poisoning . -
pubmed
However , further studies on cardiac biomarkers and other diagnostic tools in
CO poisoning are needed given the low sensitivity of
troponin I. -
pubmed
Correlation analysis showed a negative correlation between the level of
high - density lipoproteins (
HDL ) and
calcium volume ( r= -0.4104 ; r=0.023 ) ; a positive correlation between the blood
glucose level as determined by the oral
glucose tolerance test and the lipid component ( r=0.48198 ; r=0.033 ) ; and a negative correlation between the
apolipoprotein A level and the
calcium volume ( r= -0.4297 ; r=0.008).Conclusion The study demonstrated a high prevalence of vulnerable plaques in nontarget coronary arteries in
patients with
sIHD . -
pubmed
In this process ,
dyslipidemia indexes (
LDL ,
apolipoproteins A ) correlate with the
calcium volume whereas blood
glucose , as measured in the oral
glucose tolerance test , correlates with the lipid component of
coronary plaque . -
pubmed
With exception of
CRP values ( 25.0 vs. 5.0 mg / L , P = 0.015 ) , irrigation volumes ( 800 vs. 500 mL , P = 0.01 ) and total points of two predictive models ( Nomogram 1 : 88.0 vs. 76.0 , P < 0.001 ; Nomogram 2 : 76.0 vs. 39.0 , P = 0.016 ) , there was no statistical difference detected between the
fever and non - fever groups . -
pubmed
[ Effect of electroacupuncture on
Leptin in energy - regulated signaling of
obese rats with
insulin resistance ] . -
pubmed
OBJECTIVE : To observe the effect of electroacupuncture ( EA ) on
Leptin and
Leptin receptor (
OB - Rb ) of
insulin resistant
obese ( OIR )
rats , so as to explore its possible mechanism for
obesity . -
pubmed
BACKGROUND : Blood groups and
anti - A isohemagglutinin may be involved in susceptibility to
SARS - CoV-2 infection . -
pubmed
Occurrence of immune complexes in
malignant pleural effusions has been investigated by the 125I -
c1q binding test . -
pubmed
55 % of the
pleural effusions had
C1q binding activity levels higher than those found in transudates used as controls . -
pubmed
The levels of
C1q binding activity in
effusions were significantly higher than those found in the serum of the same
cancer patients . -
pubmed
High levels of
C1q binding activity were found in malignant effusion independently of type or differentiation of the
tumors involved . -
pubmed
[ Treatment of
patients with
multiple sclerosis with
transfer factor ( author 's transl ) ] . -
pubmed
These changes included an increase in muscle weight , a decline in normalised peak twitch and
tetanic tensions , and normalised force in response to different stimulation frequencies ( Rosenblatt , 1992 ) , an increase in the relative number of type I fibres and of fibres reacting with the
slow myosin heavy chain antibody , an increase in whole muscle cross - sectional area , an increase in type I and type II fibre cross - sectional area and diameter , an increase in myofibril cross - sectional area , density , number , and area fraction , and an increase in the relative proportion of intramuscular connective tissue collagen . -
pubmed
Detection of mutations in the
insulin receptor gene in patients with
insulin resistance by analysis of single - stranded conformational polymorphisms . -
pubmed
We analyzed single - stranded conformational polymorphisms to screen for mutations and polymorphisms in the
insulin receptor gene in subjects with or without
insulin resistance . -
pubmed
In addition , a new mutation was found in exon 20 of the
insulin receptor gene in a
patient with moderate
insulin resistance associated with
morbid obesity ,
acanthosis nigricans , and
polycystic ovary syndrome . -
pubmed
These data demonstrate that analysis of single - stranded conformational polymorphisms is a simple and sensitive screening method for mutations and polymorphisms in the
insulin receptor gene in subjects with or without
insulin resistance . -
pubmed
Identification of a mutation in the
insulin receptor gene in a patient with a moderate degree of
insulin resistance associated with
morbid obesity suggests that
insulin receptor mutations may exist in patients with
Type 2 ( non - insulin - dependent ) diabetes mellitus associated with a moderate degree of
insulin resistance . -
pubmed
We have used immunohistochemical methods to demonstrate the intracellular localization of the proteins
actin ,
myosin ,
tropomyosin and
vinculin , which are thought to be responsible for cellular contraction , in 26 surgically obtained epiretinal traction membranes from
patients with traumatic ( n = 12 ) and idiopathic ( n = 7 )
proliferative vitreoretinopathy , and proliferative
diabetic retinopathy ( n = 7 ) . -
pubmed
[ Multidisciplinary therapy using
interferon and immunological evaluation for
glioma patients : two - color analysis of T cell subsets ] . -
pubmed
We have employed IAR therapy [ combination of postirradiation , chemotherapy and
interferon (
IFN ) ] for
malignant glioma patients . -
pubmed
Eight
malignant glioma patients received irradiation , chemotherapy (
ACNU ) and immunotherapy ( OK-432 and
IFN - beta ) . -
pubmed
Thus we conclude that
RP 67580 , a
SP antagonist , belongs to a class of drugs that may be useful in the management of various clinical pathologies where
pain and
neurogenic inflammation are involved . -
pubmed
Linkage analysis of two
murine polycystic kidney disease genes ,
pcy and
cpk . -
pubmed
This indicates that the
cpk and pcy genes are not alleles and that the genetic mechanism of
PKD pathogenesis in the
mouse is different from that in the Cy
rat . -
pubmed
The metastatic invasion of basement membrane by
tumor cells involves the binding of
tumor cells to
laminin . -
pubmed
Both
tumor and normal cells express a high - affinity receptor for
laminin ; however , the expression is more pronounced with tumor cells . -
pubmed
The binding of
tumor cells to
laminin can be inhibited competitively by YIGSR and , in
mice , this has been shown to be translated into a reduction in metastasis . -
pubmed
Immobilized
vitronectin was found to bind both purified
plasminogen activator inhibitor type 1 (
PAI-1 ) and the
PAI-1 in conditioned culture medium of
human sarcoma cells . -
pubmed
Enzyme immunoassay of
progesterone receptor in
breast cancer biopsy samples . -
pubmed
Progesterone receptor was measured in 97
breast cancer biopsy samples with two methods , the multiple point dextran coated
charcoal method with Scatchard analysis and enzyme immunoassay . -
pubmed
[ Immunoenzyme test system with monoclonal antibodies to
human IgG4 in the determination of allergen - specific antibodies in
pollinosis ] . -
pubmed
Specific hyposensitization resulted in significant increase of
IgG4 antibody level in
patients with
tree pollen allergy . -
pubmed
Determination of
IgG4 antibodies is proved to be useful to reveal
tree pollen allergy and to monitor hyposensitization therapy . -
pubmed
The transient appearance at S2 of
anti - cytomegalovirus antibodies brought by transfusion was observed in 40 % of the cases ; seroconversion occurred in 4 % ( cytomegalovirus 3 ,
hepatitis B virus 1 ) , and 5 % of the patients developed clinical and biochemical
hepatitis without serological markers . -
pubmed
K dependence of the
Na - K pump is abnormal in erythrocytes from
patients with
cystic fibrosis and obligate heterozygotes . -
pubmed
The affinity of the
Na - K pump for K was significantly ( P less than .001 ) lower in erythrocytes from
patients with
cystic fibrosis ( Km 4.6 + /- 0.35 mM ; n = 26 ) or from heterozygotes ( Km 3.9 + /- 0.57 mM ; n = 12 ) than in controls ( Km 2.2 + /- 0.10 mM ; n = 20 ) . -
pubmed
The affinity of the
Na - K pump for K was lower in normal erythrocytes than in normal fibroblasts which may explain the variability in the severity of involvement of different organs in
cystic fibrosis . -
pubmed
We have now shown in
human skin fibroblasts and erythrocytes , that the K affinity of the
Na - K pump is lower in
patients with
cystic fibrosis than in controls . -
pubmed
These results demonstrate that the inhibition of
platelet aggregation by
compound 48 / 80 is not due solely to effects on
calmodulin as previously reported , but that inhibition of
phospholipases and probably
arachidonate mobilization may also be involved . -
pubmed
Relationship of virulent and attenuated RNA oncogenic virus antigens to surface antigens of the virus - transformed cell : implications for the
reverse transcriptase system , the provirus , protovirus and oncogene theories of
neoplasia , and the immunoprophylaxis of RNA virus - induced
tumors . -
pubmed
[ The study of
alkaline phosphatase and
5 - nucleotidase activity of peripheral neutrophils in severe
pulmonary tuberculosis ] . -
pubmed
Indirect
hypoxanthine - guanine - phosphoribosyl transferase activity determination demonstrated a normal value , and thus the possibility of
Lesch - Nyhan syndrome linked to the X - chromosome may be excluded . -
pubmed
The authors study the amount of B cells and
serum immunoglobulins in
patients with
mammary cancer or
fibrocystic disease . -
pubmed
Agents that block platelet
glycoprotein IIb / IIIa integrin , the receptor that mediates the final common pathway of
platelet aggregation , represent a promising new approach to preventing
cardiovascular ischemic complications and late restenosis after percutaneous coronary revascularization . -
pubmed
Ongoing trials are now exploring strategies for refining the practical aspects of
glycoprotein IIb / IIIa therapy and minimizing the risk of
bleeding . -
pubmed
Consistently , the total free
amino acid concentration in the gastrocnemius of
insulin - treated
rats 10 days after
tumour transplantation was close to that of controls . -
pubmed
Thyroglobulin antibodies in
type 1 diabetic patients and their relatives -- measurement with highly sensitive assay . -
pubmed
Autoimmunity in
Type 1 ( insulin - dependent ) diabetes mellitus was assessed by measuring
thyroglobulin antibodies ( TGA ) using a highly sensitive enzyme immunoassay in 65 young
patients with
Type 1 diabetes mellitus , 83 healthy first - degree relatives of the
patients , 37 healthy control subjects and 67 healthy parents of the control subjects . -
pubmed
These data suggest that
H4 interacts with the
insulin , rather than the
hypoxia / contraction , pathway for activation of
glucose transport in muscle tissue , and that
H4 acts either directly or indirectly to increase the number of
insulin receptors at the surface of the muscle cell . -
pubmed
We found that induced sputum from
asthmatic subjects had a higher percentage of eosinophils [ 8.1 + /- 3.43 ( mean + /- SEM ) versus 0.03 + /- 0.02 % , p & lt ; 0.009 ] ( after excluding squamous cells ) and also had higher levels of
albumin ( 232.3 + /- 54.8 versus 79.5 + /- 9.7 micrograms / ml , p & lt ; 0.02 ) ,
fibrinogen ( 44.2 + /- 11.6 versus 11.9 + /- 2.5 micrograms / ml , p & lt ; 0.008 ) and
eosinophil cationic protein (
ECP ) ( 142.6 + /- 34.2 versus 26.1 + /- 4.7 ng / ml , p & lt ; 0.006 ) but not of
histamine or
tryptase . -
pubmed
BACKGROUND :
Prostatic acid phosphatase (
PAP ) is an important protein which should be studied further as a
tumor marker or as a biologically functional molecule . -
pubmed
Translocation of
glucokinase in pancreatic beta - cells during acute and chronic
hyperglycemia . -
pubmed
Glucokinase (
GK ) plays a key role in the regulation of
glucose - induced
insulin secretion , and questions have been raised about its relationship to the
glucose transporter GLUT2 and its function in
diabetes . -
pubmed
GLUT2 staining was reduced overall , but variability between cells was observed , unlike the more uniform reductions seen with
hyperglycemia of longer duration . -
pubmed
Other
rats received islet transplants to prevent
hyperglycemia after Px ; their GK and
GLUT2 staining patterns were normal . -
pubmed
The translocation of this key enzyme for
glucose recognition by beta - cells may lead to altered rates of
insulin secretion during acute perturbations of fuel provision and in the
diabetic state . -
pubmed
A standardized
hyperthyroid symptom score ( HSS ) and thyroid function tests including
thyroid - stimulating hormone (
TSH ) , free
thyroxine ( free T4 ) , free
triiodothyronine ( free T3 ) , total
thyroxine ( T4 ) and total
triiodothyronine ( T3 ) were evaluated before and after 10 and 30 days of the study period . -
pubmed
The
Co ( 3 +)-insulin hexamer provides a novel prodrug approach to a soluble , prolonged - acting
insulin preparation of potential use for basal
insulin delivery in the treatment of
diabetes . -
pubmed
Hypertension risk increased with age , heart rate , serum
triglycerides ,
insulin area , and
obesity ( in young participants ) . -
pubmed
Dysfunction of
nitric oxide induces
protein kinase C activation resulting in
vasospasm after
subarachnoid hemorrhage . -
pubmed
We hypothesize that the interaction between
protein kinase C (
PKC ) and
nitric oxide (
NO ) plays a role in the modulation of cerebral vascular tone , and the disturbance of this interaction following
subarachnoid hemorrhage (
SAH ) results in
vasospasm . -
pubmed
To prove this hypothesis with direct evidence ,
PKC activities of smooth muscle cells of
canine basilar arteries in the control and in the
SAH groups were measured by an enzyme immunoassay method . -
pubmed
PKC activity in the
SAH was significantly higher than in the control ; however , no further enhancement was produced with
L - NA . -
pubmed
In the
SAH ,
PKC activity was not inhibited either by
8 - bromo - cGMP or
SIN-1 . -
pubmed
We conclude that
NO maintains an appropriate vascular tone through inactivation of
PKC , and that this effect is disturbed following
SAH , resulting in
PKC - dependent vascular contraction , such as
vasospasm . -
pubmed
When this study was repeated in the presence of
LY83583 , a
guanylate cyclase inhibitor , NP still produced
cardiac depression in the presence of
ISO . -
pubmed
Previously , we have demonstrated the direct
cytotoxicity of the bacterial toxins
Pseudomonas aeruginosa exotoxin A (
Exo A ) and
Salmonella enteritidis lipopolysaccharide ( LPS ) on pulmonary endothelial cells . -
pubmed
Pretreatment of RAEC with
db - cAMP ( 1 mM ) attenuated
Exo A induced
cytotoxicity . -
pubmed
Defects in
Bruton ' s tyrosine kinase (
Btk ) result in
B cell immunodeficiencies in
humans and
mice . -
pubmed
In a postmenopausal woman with a sonographically confirmed
ovarian tumor , a progressively rising
serum Ca-125 is highly suspicious for
malignancy . -
pubmed
Defective functional activity and accelerated apoptosis in neutrophils from
children with
cancer are differentially corrected by
granulocyte and granulocyte - macrophage colony stimulating factors in vitro . -
pubmed
In this study , PMN from
children with
cancer were evaluated to compare in vitro the corrective effects of the two
myeloid colony stimulating factors G - CSF and
GM - CSF on these defective pathways . -
pubmed
Donepezil is a
cholinesterase inhibitor used for the treatment of
patients with mild to moderately severe
Alzheimer ' s disease (
AD ) . -
pubmed
We also studied the effects of
IFN alpha on the
cytotoxicity of the
recombinant toxin TP40 which inhibits
elongation factor 2 , another step of protein synthesis , through
EGF - R binding and internalisation ;
IFN alpha induced an about 27 - fold increase of
TP40 cytotoxicity in
KB cells . -
pubmed
UNLABELLED :
Calcium chloride (
CaCl ( 2 ) ) is ineffective in severe
calcium channel antagonist
overdoses . -
pubmed
Serum
IgM levels were significantly higher in patients with larger
splenomegaly . -
pubmed
We conclude that patients with subacute symptoms but without gross
splenomegaly may have very high levels of
IgM and malarial antibodies , and relapse on re - exposure , suggesting the existence of a variant of the
hyperreactive malarial splenomegaly syndrome without gross
splenomegaly . -
pubmed
The B pocket of the
class I major histocompatibility complex - encoded protein HLA - B * 2705 has recently been suggested to be responsible for the misfolding of this HLA haplotype and thus to induce susceptibility to
autoimmune inflammatory diseases . -
pubmed
HSP70 - peptide complex could activate lymphocytes to produce specific
cytotoxicity to tumor cells , suggesting that the recombinant
human HSP70 could be used as an antigen - presenting reagent in
tumor therapy . -
pubmed
We examined maternal concentrations of
vascular endothelial growth factor and
placental growth factor in normal pregnancies and in pregnancies that were complicated by isolated idiopathic small - for - gestational - age ( SGA ) newborn infants ,
preeclampsia alone , or
preeclampsia with SGA newborn infants at the time of clinical disease and before the onset of clinical signs . -
pubmed
RESULTS : In the cross - sectional study , serum
placental growth factor was reduced in abnormal pregnancy relative to control subjects ( SGA newborn infants , 18 [ P = .04 ] ;
preeclampsia , 20 ; or
preeclampsia with small- for - gestational - age newborn infants , 11 [ P = .0001 ] ) as early as 15 to 19 weeks of gestation in
preeclampsia with
SGA newborn infants . -
pubmed
Blocking both
cytotoxic T - lymphocyte - associated antigen 4 (
CTLA-4 ) and
CD28 interactions with a
CTLA-4 / Ig fusion protein inhibits various immune - mediated processes in vivo , such as allograft rejection and
autoimmunity . -
pubmed
There have been major advances in the treatment of limited - stage
SCLC during the past decade because of early application of thoracic radiation therapy ( TRT ) with concurrent chemotherapy , accelerated TRT , the application of prophylactic cranial irradiation for
patients who achieved complete response to concurrent chemotherapy and TRT , and the improvement in supportive care such as discontinuation of
tobacco smoking after the diagnosis of
SCLC , nutritional support ,
pain control ,
granulocyte colony - stimulating factor ,
erythropoietin , and adequate antibiotics . -
pubmed
Hence ,
2OG is an intracellular indicator of
nitrogen deficiency and acts as an inducer of
nif transcription via
NrpR. -
pubmed
Inhibition of cell growth by overexpression of
manganese superoxide dismutase (
MnSOD ) in
human pancreatic carcinoma . -
pubmed
Manganese superoxide dismutase (
MnSOD ) levels have been found to be low in
human pancreatic cancer [ Pancreas 26 , ( 2003 ) , 23 ] and
human pancreatic cancer cell lines [ Cancer Res . -
pubmed
We hypothesized that stable overexpression of
pancreatic cancer cells with
MnSOD cDNA would alter the malignant phenotype . -
pubmed
These results suggest that
MnSOD may be a tumor suppressor gene in
human pancreatic cancer . -
pubmed
Cytokine gene polymorphisms and genetic association with
coeliac disease in the Finnish population . -
pubmed
We studied single -
nucleotide polymorphisms in
transforming growth factor ( TGF )- beta1 ,
interleukin ( IL )- 10 ,
IL-6 ,
interferon ( IFN )- gamma and
tumour necrosis factor ( TNF)-alpha genes in the Finnish population using family - based association approach . -
pubmed
We did not find evidence of association between
TGF - beta1 ,
IL-10 ,
IL-6 and
IFN - gamma polymorphisms and
CD susceptibility . -
pubmed
No association was found for any of the
MICA alleles independently of DQ genes , whereas TNF - alpha-308 A allele was slightly overrepresented on chromosomes carried by
CD patients compared with control chromosomes , indicating that either
TNF - alpha , or another gene in linkage disequilibrium with it , could confer increased susceptibility to
CD . -
pubmed
Elevated
monocyte chemoattractant protein-1 serum levels in
patients at risk for
coronary artery disease . -
pubmed
BACKGROUND :
Monocyte chemoattractant protein-1 (
MCP-1 ) is involved in the recruitment of monocytes into the arterial vessel wall as one of the major events leading to
atherosclerotic vascular diseases , such as
coronary artery disease (
CAD ) . -
pubmed
Patients with
CAD proven by angiography had significantly increased
MCP-1 levels . -
pubmed
In
patients without
CAD , the increase in
MCP-1 depended on the number of
CRF . -
pubmed
As a marker for endothelial activation the soluble
adhesion molecules , soluble
intercellular adhesion molecule and soluble
E - selectin were measured and both markers were significantly elevated in
patients with
CAD or multiple
CRF when compared with
patients without
CRF . -
pubmed
Although this is not a direct proof , endothelial activation could contribute to elevated
MCP-1 levels in
atherosclerosis . -
pubmed
CONCLUSION : Elevated
MCP-1 serum levels could serve as a direct marker of the inflammatory activity in
patients at risk for coronary artery and other
atherosclerotic vascular diseases . -
pubmed
One of the mechanisms involved in the progression of
diabetic nephropathy , the most common cause of
end - stage renal failure , is angiogenic phenomenon associated with the increase of angiogenic factors such as
vascular endothelial growth factor ( VEGF )- A and
angiopoietin ( Ang )- 2 , an antagonist of
Ang-1 . -
pubmed
[
Cytotoxic T lymphocyte antigen-4 promoter gene polymorphism is significantly associated with
ulcerative colitis ] . -
pubmed
The aim of the present study is to investigate the association between
CTLA-4 promoter -1722 ( T / C ) , -1661 ( A / G ) polymorphisms and
ulcerative colitis (
UC ) in Han Chinese , in Hubei province of central China . -
pubmed
METHODS : Eighty - seven patients with
UC and 116 healthy controls were genotyped for
CTLA-4 promoter -1722 and -1661 polymorphisms with a method of polymerase chain reaction based restriction fragment length polymorphism . -
pubmed
CONCLUSION : The G allele of
CTLA-4 promoter -1661 polymorphism showed a highly significant association with
UC in Han Chinese of the central China . -
pubmed
The clinical and laboratory response to
recombinant factor VIIA in
trauma and surgical
patients with acquired
coagulopathy . -
pubmed
OBJECTIVE : In
bleeding patients who are
coagulopathic , the clinical response to administration of
recombinant factor VIIa (
rFVIIa ) relates to the changes in
prothrombin time ( PT ) . -
pubmed
DESIGN : Retrospective review of all surgical and
trauma patients who were
coagulopathic and received
factor VIIa at the authors ' institution over the past 27 months . -
pubmed
There were no significant differences in percentage PT decrease between dose & gt ; or = 100 mcg / kg vs & lt;100 mcg / kg , surgical vs
trauma patients , survivors vs nonsurvivors , and those with pretreatment platelet count & gt ; or = 100 K vs & lt;100 K. CONCLUSIONS : The administration of
rFVIIa caused a decrease in the PT in nearly all
patients . -
pubmed
Barth syndrome (
BTHS ) is a
mitochondrial disorder that is caused by mutations in the
tafazzin gene , which affects
phospholipid composition . -
pubmed
SUPPORTING EVIDENCE FOR THE HYPOTHESIS : This hypothesis results from previous studies showing that
IgG1 and
IgG3 responses against antigens like ring - infected erythrocyte surface antigens ,
merozoite surface proteins and variant surface antigens on schizonts were associated with clinical immunity against
malaria . -
pubmed
The resulting pattern of responses for each
immunoglobulin isotype could be compared between clinically immune participants remaining asymptomatic with subsequent
P. - pubmed
These mutants were characterized in an optimized
T - cell factor (
TCF)-
luciferase based assay in
U2OS human osteosarcoma cells . -
pubmed
Pharmacological agents such as statins and
angiotensin - converting enzyme inhibitors may promote tissue stabilization in
AAA by diminishing pro - inflammatory signaling and normalizing metabolism of the ECM . -
pubmed
Our recent experiments in
animal models demonstrate that inhibition of
c - Jun N terminal kinase (
JNK ) inhibits multiple pathological processes and causes regression of established
AAA . -
pubmed
CONCLUSION : Most women have
antibodies to
HSV-1 , which is partially protective against
HSV-2 infection . -
pubmed
Small molecules inhibiting the proliferative cascade of the
cancer cells and monoclonal specific antibodies against growth factor or
vascular endothelial growth factor have been claimed as the promise in
cancer therapy . -
pubmed
Donor
CTLA-4 +49 A / G*GG genotype is associated with
chronic GVHD after HLA - identical haematopoietic stem - cell transplantations . -
pubmed
Apolipoproteins B and AI and the risk of ischemic cerebrovascular events in
patients with pre - existing
atherothrombotic disease . -
pubmed
We examined the association between serum concentrations of
Apo B ,
Apo A - I , and the
Apo A - I /
Apo B ratio and the risk of incident
ischemic cerebrovascular events in
patients with pre - existing
atherothrombotic disease . -
pubmed
METHODS :
Patients with documented chronic
coronary heart disease and measured
Apo B and
Apo A - I concentration , screened for but not included in a clinical trial of lipid modification were followed over 4.8 to 8.1 years for hospitalized incident cerebrovascular events . -
pubmed
Adjusting for potential confounders , the hazard ratios ( HR ) for incident
ischemic cerebrovascular events associated with the top versus bottom quartile of
Apo B was 1.68 ( 95%CI , 1.18 - 2.40 ) , of
Apo A - I 0.71 ( 95%CI , 0.50 - 1.00 ) , and of
Apo A - I /
Apo B ratio 0.51 ( 95%CI , 0.35 - 0.74 ) . -
pubmed
CONCLUSIONS : These findings support the hypothesis that
Apo B ,
Apo A - I and the
Apo A - I /
Apo B ratio predict incident
ischemic stroke among
patients with preexisting
atherothrombotic disease . -
pubmed
The potential clinical role of measuring these
apolipoproteins for
ischemic stroke prediction warrants further study . -
pubmed
Humans exposed prenatally to
ethanol can exhibit
brain abnormalities and
cognitive impairment similar to those seen in
patients expressing mutant forms of the
L1 cell adhesion molecule (
L1CAM ) . -
pubmed
BACKGROUND : Serum
copper not bound to
ceruloplasmin ( " free " ) appears slightly elevated in
patients with
Alzheimer disease (
AD ) . -
pubmed
METHODS : We assessed levels of
copper ,
iron ,
zinc ,
transferrin ,
ceruloplasmin ,
peroxides , total antioxidant capacity , free
copper , and
apolipoprotein E genotype in 81
patients with mild or moderate
AD , mean age 74.4 , SD = 7.4 years , clinically followed up after 1 year . -
pubmed
Effect of antisense oligomer in controlling
c - raf.1 overexpression during
diethylnitrosamine - induced
hepatocarcinogenesis in
rat . -
pubmed
PURPOSE : In
ras - mediated signal transduction pathway ,
c - raf.1 is believed to have predominant oncogenic potential and has been found to be highly expressed in certain
human and
animal malignancies including
hepatocellular carcinoma . -
pubmed
RESULTS :
c - raf.1 antisense oligomers exhibited an inhibitory effect ( approximately 68 % ) on
cancer cell proliferation in vitro . -
pubmed
CONCLUSION : The study demonstrates that the antisense oligomer targeted against
c - raf.1 mRNA inhibits the overexpression of
c - raf.1 gene during
hepatocellular carcinoma in
rats . -
pubmed
However , we find that this homeostatic mechanism can lead to massive over - proliferation of intestinal cells when
infection occurs in
animals with a latent oncogenic form of the
Ras1 oncogene . -
pubmed
Treatment consists of an
angiotensin - converting enzyme inhibitor and/or beta blocker if needed for
left ventricular dysfunction and possibly an anxiolytic agent . -
pubmed
AIM OF THE STUDY :
Rheumatoid arthritis synovial fibroblasts ( RASFs ) are known to produce
matrix metalloproteinases (
MMPs ) and cause joint destruction . -
pubmed
The anti -
CD20 monoclonal antibody rituximab is an effective treatment for
small lymphocytic lymphoma ; however , it has been associated with infusion reactions , including
cardiac arrhythmias . -
pubmed
METHODS : The expression levels of
h - TERT ,
CK20 ,
CEA , and
C - MET were detected in a model of circulating micrometastasis in
pancreatic cancer that were enriched using immune - magnetic separation of the circulating
cancer cells . -
pubmed
The positive expression rates of
C - MET , h -
TERT ,
CK20 , and
CEA in the
pancreatic cancer group were 80 % ( 20/25 ) , 100 % ( 25/25 ) , 84 % ( 21/25 ) , and 80 % ( 20/25 ) , respectively , while in the benign
disease control group the rates were 0 % ( 0/15 ) , 0 % ( 0/15 ) , 6.77 % ( 1/15 ) , and 0 % ( 0/15 ) , respectively . -
pubmed
The positive expression rate of the four genes was not related to gender , age ,
tumor size , CA 19 - 9 , or
CEA serum levels ( P>0.05 ) . -
pubmed
However , the positive expression of
C - MET ,
CK20 , and
CEA closely correlated with
tumor stage ( P<0.05 ) . -
pubmed
CONCLUSIONS : The positive expression of
C - MET , h -
TERT ,
CK20 , and
CEA in the circulation of pancreatic
patients could be used as an indicator for circulating
cancer cells . -
pubmed
CONCLUSION : Retracted musculotendinous units have deteriorated tendons , characterized by increased
collagen fiber crimp , and ultrastructural
collagen fibril
atrophy and disorganization . -
pubmed
For secondary prevention , high
triglycerides or low
HDL - C , but not
LDL - C , significantly increased the relative risk of cardiac events in the
patients with complication of
cardiac disease . -
pubmed
CONCLUSIONS : The LEM study , a large - scale prospective study of long - term
fluvastatin treatment for
hypercholesterolemia in Japanese
patients , demonstrated high impact of complications such as
DM and
hypertension as well as high
triglycerides or low
HDL - C on cardiac and cerebral events . -
pubmed
The aim of this study was to identify the alterations in N - glycans in
human OA cartilage , to characterize the messenger RNA ( mRNA ) expression of N - glycan biosynthesis enzyme genes (
N - glycogenes ) in
mouse articular chondrocytes during cartilage degradation , and to analyze the relationship between altered N - glycan patterns and mechanisms of cartilage degradation . -
pubmed
dexamethasone , preoperative administration of analgesia including the use of non - steroidal anti - inflammatory or
COX II inhibitors , intraoperative use of an anti - emetic , pre - incisional use of
bupivacaine , administration of intraperitoneal
bupivacaine on establishment of
pneumoperitoneum , and avoidance of drains . -
pubmed
OPA1 mutations in Japanese patients suspected to have
autosomal dominant optic atrophy . -
pubmed
PURPOSE : To report three types of heterozygous mutations in the
OPA1 gene in five
patients from three families with
autosomal dominant optic atrophy (
ADOA , MIM#165500 ) . -
pubmed
CONCLUSION :
OPA1 mutations existed in three Japanese families with
ADOA . -
pubmed
After a detailed clinical assessment of the proband , the screening of the
OPA1 gene may be helpful for precise diagnosis of
ADOA , provided the relevant information of the family members is limited . -
pubmed
Concurrent
CIC mutations ,
IDH mutations , and 1p/19q loss distinguish
oligodendrogliomas from other
cancers . -
pubmed
In addition , we discovered somatic mutations and insertions / deletions in the
CIC gene on chromosome 19q13.2 in 13/16
tumours . -
pubmed
CIC mutations were highly associated with
oligodendroglioma histology , 1p/19q co - deletion , and
IDH1/2 mutation ( p & lt ; 0.001 ) . -
pubmed
We hypothesize that the mutant CIC on the single retained 19q allele is linked to the pathogenesis of
oligodendrogliomas with
IDH mutation . -
pubmed
Our detailed study of genetic aberrations in
oligodendroglioma suggests a functional interaction between CIC mutation ,
IDH1 / 2 mutation , and 1p/19q co - deletion . -
pubmed
Since the rough strain
Brucella melitensis B115 was able to protect
mice against wild Brucella strains
brucellosis despite the lack of
anti - OPS antibodies , in this study we evaluated the biological significance of
antibodies induced by this strain , directed to antigens other than
O - PS , passively tranferred to untreated
mice prior to infection with
Brucella abortus 2308 and
B. - pubmed
Airway inflammation induced by CS was demonstrated by pathologic changes of lung tissue and increased level of
CXCL-8 . -
pubmed
Moreover , a negative correlation was found between
HDAC-2 activity and a
lung destruction index . -
pubmed
These results indicate that low - dose
theophylline might provide protection from
smoke damage and improve the anti - inflammatory effects of
steroids by increasing
HDAC-2 activity . -
pubmed
FOXA1 promotes
tumor progression in
prostate cancer via the
insulin - like growth factor binding protein 3 pathway . -
pubmed
However , the precise role of
FOXA1 in
prostate cancer (
PC ) remains unknown . -
pubmed
In this study , we report that
FOXA1 plays a critical role in
PC cell proliferation . -
pubmed
The expression of
FOXA1 was higher in
PC than in
normal prostate tissues ( P = 0.0002 ) , and , using immunohistochemical analysis , we found that
FOXA1 was localized in the nucleus . -
pubmed
Depletion of
FOXA1 in a
prostate cancer cell line (
LNCaP ) using small interfering RNA ( siRNA ) significantly inhibited
AR activity , led to cell - growth suppression , and induced G0 / G1 arrest . -
pubmed
These findings provide direct physiological and molecular evidence for a role of
FOXA1 in controlling cell proliferation through the regulation of
IGFBP-3 expression in
PC . -
pubmed
The disruption of
sucrose movement in the phloem in
tdy2 mutants provides evidence that the
Tdy2 callose synthase functions in vascular maturation and that the
vascular defects result in impaired symplastic trafficking into the phloem translocation stream . -
pubmed
The use of
CD138 positively selected marrow samples increases the applicability of minimal residual disease assessment by PCR in patients with
multiple myeloma . -
pubmed
We have evaluated the use of
CD138 + positively selected bone marrow samples to identify a molecular target for minimal residual disease assessment by polymerase chain reaction ( PCR ) in 25 untreated
patients with
multiple myeloma . -
pubmed
We conclude that the use of
CD138 + positively selected bone marrow samples increases the applicability of minimal residual disease studies by PCR in patients with
multiple myeloma . -
pubmed
Combination of
recombinant factor VIIa and
fibrinogen corrects clot formation in
primary immune thrombocytopenia at very low platelet counts . -
pubmed
This study challenged the hypothesis that
recombinant activated factor VII (
rFVIIa ) combined with
fibrinogen concentrate may correct whole blood ( WB ) clot formation in
ITP . -
pubmed
Blood from
ITP patients ( n = 12 ) was drawn into tubes containing 3 2 %
citrate and
corn trypsin inhibitor 18 3 mug / ml . -
pubmed
These data suggest that rFVIIa combined with
fibrinogen corrects the
coagulopathy of
ITP even at very low platelet counts , and may represent an alternative to platelet transfusion . -
pubmed
Role of the
TNFA -308 G & gt ; A polymorphism in the genetic susceptibility to
acne vulgaris in a Sicilian population . -
pubmed
The aim of the present study was to investigate whether
TNFA -308 G & gt ; A polymorphism might be involved in the pathogenesis of
acne in a population from Sicily . -
pubmed
A significant protective association between the
TNFA -308 GA genotype and
acne in males ( p = 0.027 ; OR95 % CI : 0.288 ; 0.094 - 0.889 ) was shown . -
pubmed
CONCLUSIONS : The present results suggest that
TNFA -308 polymorphism may contribute to
acne susceptibility , as suggested by the protective effect of the G / A phenotype in the males of the Sicilian cohort . -
pubmed
Further studies in larger groups , investigating the
TNFA -308G / A or other polymorphisms of this gene in
acne patients may be helpful to clarify the pathogenesis of the disease . -
pubmed
The
proprotein convertases (
PCs ) are
serine proteases responsible for the proteolytic maturation of many precursor proteins involved in upper airway remodelling during
nasal polyposis . -
pubmed
However , whether
PC1 / 3 is related to nasal
polyp formation has not been investigated . -
pubmed
To gain insight into the functional role of
PC1 / 3 in nasal
polyps , we determined
PC1 / 3 expression in nasal
polyps by immunostaining , Western blotting and enzyme assays and generated stable cells expressing
PC1 / 3 using airway epithelial cell line
NCI - H292 . -
pubmed
Nasal
polyps exhibit increased
PC1 / 3 expression compared to normal nasal mucosa . -
pubmed
PC1 / 3 was expressed in neuroendocrine cells in normal nasal mucosa and it was also expressed in goblet and ciliated cells in nasal
polyps . -
pubmed
Importantly ,
PC1 / 3 expression was positively correlated with epithelial - mesenchymal transition in cultured
human nasal epithelial cells and in nasal
polyps . -
pubmed
Taken together , our data suggest that
PC1 / 3 overexpression induces morphological and phenotypic epithelial - mesenchymal transition changes of airway epithelial cells and these changes may contribute to the pathogenesis of
nasal polyps . -
pubmed
Although transplantation of
c - kit+ cardiac stem cells ( CSCs ) alleviates post -
myocardial infarction left ventricular dysfunction , there are no reliable methods that enable measurement of the absolute number of CSCs that persist in the recipient heart . -
pubmed
CNTNAP2 is a gene on chromosome 7 that has shown associations with
autism and
schizophrenia , and there is evidence that it plays an important role for neuronal synchronization and brain connectivity . -
pubmed
81 healthy controls and 44
patients with
schizophrenia ( all Caucasian ) underwent DTI and genotyping of 31 SNPs within
CNTNAP2 . -
pubmed
We present new evidence about the effects of
CNTNAP2 on brain connectivity , whose disruption has been hypothesized to be central to
schizophrenia pathophysiology . -
pubmed
Preclinical studies of a specific
PPARgamma modulator in the control of
skin inflammation . -
pubmed
Consistently ,
PPARgamma agonists have been proposed in various
inflammatory skin disorders , but their wide use has been limited by severe side effects . -
pubmed
In
psoriasis - like
skin lesions elicited in
mice by
IL-21 , topical application of GED-0507 - 34L reduced cellular infiltrate and
epidermal hyperplasia , normalizing the differentiation process . -
pubmed
[ A comparative study of the effects of needle free ( INJEX30 ) versus
insulin pen injection on
insulin absorption in
diabetic patients ] . -
pubmed
OBJECTIVE : To evaluate the effect of the needle free injection system ( INJEX30 ) and
insulin pen on
insulin absorption and glycemic control in
diabetic patients . -
pubmed
METHODS : A total of 30
diabetic patients on
insulin therapy without obvious complications were enrolled in the study with average BMI of 25.24 kg / m(2 ) . -
pubmed
Iron - deficiency anemia and
diabetes mellitus were associated with a very high
TPMT activity ( p = 0.0004 and p = 0.0015 , respectively ) . -
pubmed
Protein kinase inhibitors to treat
non - small - cell lung cancer . -
pubmed
INTRODUCTION : Activating mutations of the
EGFR and rearrangement of
anaplastic lymphoma kinase (
ALK ) best illustrate the therapeutic relevance of molecular characterization in
NSCLC patients . -
pubmed
AREAS COVERED : For this review article , all published data on the most relevant Phase III trials with
tyrosine kinase inhibitors ( TKIs ) for the treatment of
NSCLC were collected and analyzed . -
pubmed
In pretreated
NSCLC ,
EGFR TKIs are considered more effective than standard monotherapy with cytotoxics in presence of classical
EGFR mutations , whereas in the
EGFR wild - type population , a similar efficacy to
docetaxel or
pemetrexed in term of survival has been demonstrated . -
pubmed
In
ALK - translocated
NSCLC , a Phase III trial demonstrated the superiority of a multi - target TKI , including
ALK , in terms of progression - free survival , response rate and toxicity profile when compared to standard second - line chemotherapy . -
pubmed
Screening of
diabetes of youth for
hepatocyte nuclear factor 1 mutations : clinical phenotype of
HNF1beta - related maturity - onset
diabetes of the young and
HNF1alpha - related maturity - onset
diabetes of the young in Japanese . -
pubmed
AIM : To compare the prevalence and clinical features of
HNF1beta - related
MODY and
HNF1alpha - related
MODY in Japanese . -
pubmed
METHODS : We enrolled 230 Japanese
patients with suspected
MODY and examined them for
HNF1alpha and
HNF1beta mutations . -
pubmed
We characterized the clinical features of
HNF1beta - related
MODY (
HNF1beta - MODY ) and
HNF1alpha - related
MODY (
HNF1alpha - MODY ) . -
pubmed
Five of the
patients with
HNF1beta - MODY had
insulin secretion defects and were treated with
insulin , and four of these did not have a parent with overt
diabetes . -
pubmed
CONCLUSION :
HNF1beta - MODY may present as
beta - cell dysfunction in Japanese rather than as
hyperinsulinaemia , which it does among European / American . -
pubmed
Urinary
neutrophil gelatinase - associated lipocalin as an early predictor of disease severity and mortality in
acute pancreatitis . -
pubmed
The aim of the study was to assess whether urinary level of
neutrophil gelatinase - associated lipocalin (
NGAL ) could represent a useful marker of
AP severity . -
pubmed
CONCLUSIONS : The urinary level of
NGAL is a promising new diagnostic and prognostic factor for severe
AP in an early stage of the disease . -
pubmed
Recent research supposes
endocan as a biomarker for evaluating cardiovascular events ,
inflammatory diseases , and
cancers . -
pubmed
propose serum
endocan levels as a novel prediction marker of all - cause mortality and cardiovascular events in
CKD patients . -
pubmed
TRPML1 has been associated with
mucolipidosis type IV (
MLIV ) , while no disease phenotype has been linked with
TRPML2 or - 3 protein . -
pubmed
In summary , these data indicate cell - communication associated with three - dimensional islet architecture is important both for effective
insulin secretion and for protection of
human beta cells against
cytotoxicity . -
pubmed
Attenuated phagocytosis of secondary
necrotic neutrophils by macrophages in aged and
SMP30 knockout
mice . -
pubmed
AIM : Secondary
necrotic cells generated in vivo induce inflammatory responses ; for example , the production of
macrophage inflammatory protein-2 (
MIP-2 ) and subsequent infiltration of neutrophils . -
pubmed
METHODS : The phagocytosis of secondary
necrotic neutrophils with resident macrophage from either WT young
mice , WT aged
mice or
SMP30(-/- )
mice was examined by coculturing macrophages with secondary
necrotic neutrophils in vitro . -
pubmed
To investigate the inflammatory response induced by secondary necrotic cells , time - dependent infiltration of neutrophils and production of
MIP-2 were determined in the peritoneal cavity on the injection of secondary
necrotic cells . -
pubmed
On peritoneal injection of secondary
necrotic cells , the peak time of neutrophil infiltration was earlier in
SMP30(-/- )
mice than in WT young
mice . -
pubmed
CONCLUSIONS : Our findings showed that the phagocytosis of secondary necrotic cells was attenuated in aged
mice and
SMP30 (-/- ) mice , and that the
MIP-2 production was enhanced and subsequently neutrophil infiltration was exaggerated on peritoneal injection of secondary
necrotic cells into those
mice . -
pubmed
We describe recent findings that associate
Activin /
Nodal signalling to pathological conditions , focusing on
cancer stem cells in tumorigenesis and its potential as a target for therapies . -
pubmed
Previous studies in
vanadium toxicity showed involvement of oxidative stress in isolated liver hepatocytes and mitochondria via increasing of ROS formation , release of
cytochrome c and
ATP depletion after incubation with different concentrations ( 25 - 200 microM ) . -
pubmed
Adding MRI to annual mammography screening improves early
breast cancer detection in women with familial risk or
BRCA1 / 2 mutation , but
breast cancer specific metastasis free survival ( MFS ) remains unknown . -
pubmed
Of 2,308 MRISC participants ,
breast cancer was detected in 93 ( 97
breast cancers ) , who received MRI & lt;2 years before
breast cancer diagnosis ; 33
BRCA1 mutation carriers , 18
BRCA2 mutation carriers , and 42 with familial risk . -
pubmed
MFS was better in
MRISC patients overall ( log - rank p = 0.008 , HR 0.36 , 95 % CI 0.16 - 0.80 ) , with familial risk ( log - rank p = 0.024 , HR : 0.21 , 95 % CI 0.04 - 0.95 ) , and in
BRCA1 mutation carriers ( log - rank p = 0.055 , HR 0.30 , 95 % CI 0.08 - 1.13 ) . -
pubmed
Anti -
E1E2 antibodies do predict response to triple therapy in
treatment - experienced Hepatitis C Virus - cirrhosis cases . -
pubmed
BACKGROUND AND AIMS : We previously showed that pre - treatment serum anti -
E1E2 predicted
hepatitis C virus (
HCV ) RNA viral kinetics ( VKs ) and treatment outcome in
patients with
chronic hepatitis C receiving
pegylated interferon / ribavirin (
Peg - IFN / RBV ) double therapy . -
pubmed
Here , we determined whether baseline anti -
E1E2 was correlated with the on - treatment VK and could predict virological outcome in treatment - experienced
HCV - infected
cirrhotic patients receiving protease inhibitor - based triple therapy . -
pubmed
Rapamycin , an
mTOR inhibitor , induced apoptosis via independent mitochondrial and death receptor pathway in
retinoblastoma Y79 cell . -
pubmed
Rapamycin is helpful in the treatment of certain
cancers by inhibiting
mTOR (
mammalian target of rapamycin ) pathway . -
pubmed
Hepatoma - derived Growth Factor Predicts Disease Severity and Survival in
Pulmonary Arterial Hypertension . -
pubmed
OBJECTIVES : We sought to assess the relationship of serum
hepatoma - derived growth factor (
HDGF ) with
PAH disease severity and survival . -
pubmed
Importantly , serum
HDGF levels were not elevated in a
noncardiac chronic disease cohort . -
pubmed
CONCLUSIONS : Elevated
HDGF was associated with worse functional class ,
exertional intolerance , and increased mortality in
PAH , suggesting
HDGF as a potential biomarker for predicting mortality and as having possible diagnostic value for distinguishing PAH from non - PAH . -
pubmed
HDGF may add additional value in
PAH risk stratification in clinical trials and may represent a potential target for future PAH drug development . -
pubmed
There is very little direct research to conclusively prove the relevance of diet in primary
tendinopathies , however it seems prudent to ask whether our current knowledge about the impact of nutrition on
collagen metabolism could be useful in assessing , preventing , or treating
tendinopathy . -
pubmed
These can be detected immunohistochemically using anti -
CD138 antibodies , which should be carried out particularly in cases of
infertility with only slight inflammatory symptoms and few plasma cells . -
pubmed
In contrast to pancreatic and
gastric cancer patients ,
CRC subjects presented neither an increase in the number of circulating SCs nor the activation of pro - mobilizing factors such as complement , coagulation and fibrinolytic cascade , circulating
stromal derived factor 1 (
SDF-1 ) ,
vascular endothelial growth factor (
VEGF ) and intestinal permeability marker (
zonulin ) . -
pubmed
METHODS : Preoperative lipid levels ( total
cholesterol ,
LDL cholesterol ,
HDL cholesterol and
triglycerides ) and statin use from consecutive
patients with clinically localized
PCa undergoing RP in a tertiary referral center between 2008 and 2015 were recorded and
patients were followed prospectively . -
pubmed
Preoperative
LDL cholesterol remained an independent predictor for
PCa recurrence in a multivariable model adjusted for age , preoperative
PSA , statin use ,
tumor stage , Gleason score , nodal status and surgical margin status ( continuous : HR : 0.66 , 95%-CI : 0.44 - 0.99 , P = 0.04 ; 3 mM cut - point : HR : 0.41 , 95%-CI : 0.21 - 0.78 , P = 0.007 ) . -
pubmed
CONCLUSIONS : This is the first prospective study showing the potential adverse and independent prognostic role of low preoperative
LDL cholesterol levels in
patients with localized
PCa undergoing RP . -
pubmed
After adjusting for maturation and ethnicity , indirect measures of adiposity accounted for 29 - 34 % in HOMA - IR , 10 - 13 % in
TG , 14 - 17 % in
HDL - C , and 5 - 8 % in
LDL - C while direct measures accounted for 29 - 34 % in HOMA - IR , 10 - 12 % in
TG , 13 - 16 % in
HDL - C , and 5 - 6 % in
LDL - C. The addition of direct measures of adiposity to indirect measures added significantly to the variance explained for HOMA - IR ( p = 0.04 ) . -
pubmed
Knockdown of mediator subunit
Med19 suppresses
bladder cancer cell proliferation and migration by downregulating Wnt /
beta - catenin signalling pathway . -
pubmed
Mediator complex subunit 19 (
Med19 ) , a
RNA polymerase II - embedded coactivator , is reported to be involved in
bladder cancer ( BCa ) progression , but its functional contribution to this process is poorly understood . -
pubmed
Med19 expression in 15
BCa tissues was significantly higher than adjacent paired
normal tissues using real - time PCR and Western blot analysis . -
pubmed
Immunohistochemical staining of 167 paraffin - embedded
BCa tissues was performed , and the results showed that high
Med19 protein level was positively correlated with clinical stages and histopathological grade . -
pubmed
Functional assays showed that knocking - down of
Med19 can suppress cell proliferation and migration in
T24 ,
UM - UC3 cells and
5637 in vitro , and inhibited BCa
tumour growth in vivo . -
pubmed
Our data suggest that
Med19 expression correlates with aggressive characteristics of
BCa and
Med19 knockdown suppresses the proliferation and migration of BCa cells through down - regulating the Wnt /
beta - catenin pathway , thereby highlighting
Med19 as a potential therapeutic target for
BCa treatment . -
pubmed
In this study , we found that
hypoxia could promote umbilical cord mesenchymal stem cells ( UCMSCs ) differentiation into ATII cells rather than into fibroblast - like cells , and this effect was mainly mediated by microRNA-145 ( miR-145 ) , which could induce the inhibition of
TGF - beta signaling by targeting
TGF - beta receptor II (
TGFbetaRII ) . -
pubmed
Quadruple immunotherapy of
Bacillus Calmette - Guerin ,
interferon ,
interleukin-2 , and
granulocyte - macrophage colony - stimulating factor as salvage therapy for
non - muscle - invasive bladder cancer . -
pubmed
ERCC1 expression status predicts the response and survival of
patients with metastatic or recurrent
cervical cancer treated via
platinum - based chemotherapy . -
pubmed
Our aim was to explore whether
ERCC1 expression predicted
tumor response and survival in
patients with recurrent or metastatic
cervical cancer treated via
platinum - based chemotherapy . -
pubmed
The median progression - free survival differed significantly by
ERCC1 status , being 135 days in
ERCC1 - high and 242 days in
ERCC1 - low patients ( hazard ratio , 2.428 ; 95 % confidence interval , 1.145 - 5.148 , P = .032 ) . -
pubmed
Thus , pretreatment
ERCC1 expression status can be used to predict
tumor response and survival of
patients with recurrent or metastatic
uterine cervical cancer receiving
platinum - based chemotherapy . -
pubmed
Our results showed marked increase in all measured parameters except
SOD , TAC ,
eNOS immunoexpression and Bcl2 mRNA gene expression which decreased in
Cd induced
hepatotoxicity group . -
pubmed
The natural course of classical
diabetic nephropathy is initially
microalbuminuria or moderately increased urine
albumin excretion ( 30 - 300mg / g
creatinine ) . -
pubmed
The frequency and magnitude of
anti - LT toxin ,
CFA / I and LPS O78 immune responses were antigen , dose , severity of
diarrhea and shedding levels dependent . -
pubmed
Carboplatin in
BRCA1 / 2 - mutated and triple - negative
breast cancer BRCAness subgroups : the TNT Trial . -
pubmed
Germline mutations in
BRCA1 / 2 predispose individuals to
breast cancer ( termed germline - mutated
BRCA1 / 2 breast cancer , gBRCA - BC ) by impairing homologous recombination ( HR ) and causing genomic instability . -
pubmed
HR also repairs DNA
lesions caused by
platinum agents and
PARP inhibitors . -
pubmed
Triple - negative
breast cancers (
TNBCs ) harbor subpopulations with
BRCA1 / 2 mutations , hypothesized to be especially
platinum - sensitive . -
pubmed
Cancers in putative ' BRCAness ' subgroups -
tumors with
BRCA1 methylation ; low levels of
BRCA1 mRNA (
BRCA1 mRNA - low ) ; or mutational signatures for
HR deficiency and those with basal phenotypes - may also be sensitive to
platinum . -
pubmed
Such benefit was not observed for subjects with
BRCA1 methylation ,
BRCA1 mRNA - low tumors or a high score in a Myriad HRD assay . -
pubmed
We conclude that patients with advanced
TNBC benefit from characterization of
BRCA1 / 2 mutations , but not
BRCA1 methylation or Myriad HRD analyses , to inform choices on
platinum - based chemotherapy . -
pubmed
Hypotension , but not the increase in colorectal pressure , was inhibited by a 10 - min pretreatment with the
NK1 receptor antagonist
CP-99,994 . -
pubmed
miR-665 promotes
hepatocellular carcinoma cell migration , invasion , and proliferation by decreasing
Hippo signaling through targeting
PTPRB . -
pubmed
Tyrosine phosphatase receptor type B (
PTPRB ) was downregulated in
HCC tissues , and was negatively correlated with miR-665 expression . -
pubmed
Restoration of
PTPRB reverses the effects of miR-665 on
HCC migration , invasion , and cell proliferation . -
pubmed
In conclusion , our results suggested that miR-665 was a negative regulator of the
PTPRB and could promote
tumor proliferation and metastasis in
HCC through decreasing Hippo signaling pathway activity , which can be a potential target for
HCC treatment . -
pubmed
While
glimepiride stimulates beta - cell secretion and leads to a reduction of blood
glucose levels ,
pioglitazone activates
peroxisome proliferator - activated receptor - gamma and improves
insulin resistance . -
pubmed
The Combined Use of
Phenothiazines and Statins Strongly Affects
Doxorubicin - Resistance , Apoptosis , and
Cox-2 Activity in
Colon Cancer Cells . -
pubmed
The effect of three
phenothiazine derivatives that were used as single agents and in combination with
simvastatin on cell growth , apoptosis induction , activity , and expression of
cyclooxygenase-2 (
COX-2 ) in
doxorubicin - resistant
colon cancer cells (
LoVo / Dx ) was investigated . -
pubmed
UTX ( also known as
KDM6A ) , a
histone 3 lysine 27 demethylase , is among the most frequently mutated epigenetic regulators in
myelodysplastic syndrome (
MDS ) and
acute myeloid leukemia (
AML ) . -
pubmed
Recent studies have suggested that
UTX mutations promote
MDS and
AML by blocking the differentiation of hematopoietic stem and progenitor cells ( HSPCs ) . -
pubmed
Further ,
SP2509 promoted the differentiation of
Utx - null
AML cells in vitro and in vivo and , therefore , extended the survival of these leukemic
mice . -
pubmed
Thus , our study identified a novel strategy to specifically target both premalignant and malignant cells with
Utx deficiency for differentiation therapy and provided insights into the molecular mechanisms underlying the role of
Utx in regulating HSPCs and related diseases . -
pubmed
The laboratory results revealed WBC count of 20.6 x 103 / mm3 ( 76.9 % neutrophils ) ,
CRP (
c - reactive protein ) of 33 mg / L and erythrocyte sedimentation of 110 / h. The
patient was referred to a dermatologist with prediagnosis of
SS due to the presence of typical painful
skin lesions , high
fever and
neutrophilic leukocytosis . -
pubmed
The aim of our study was to evaluate the effect of ancestral
TCDD exposure on
ovarian toxicity in offspring
rats ( F3 ) , focusing on the
Igf2 /
H19 pathway which was important for follicular development . -
pubmed
The successful in vitro and in vivo delivery of siRNA , as well as targeted gene knockdown potential , was demonstrated by
HDAC4 inhibition in vitro
diabetic nephropathy ( DN ) podocyte model as well as in vivo DN
C57BL / 6 mice model . -
pubmed
japonicum extract exhibits antidepressant - like activity in
CORT - induced
depressive mice , which might be as a result of increased
BDNF expression . -
pubmed
The purpose of this article is to review and investigate further the molecular mechanism by which the
SARS - CoV2 virus infection proceeds via the formation of a hetero - trimer between its
protein S , the
ACE2 receptor and the
B0AT1 protein , which is the " entry receptor " for the
infection process involving membrane fusion ( Li et al . -
pubmed
Although the mechanisms of action underlying the
glucose - lowering properties of
HCQ are still not entirely clear , evidence suggests that this drug may exert multifaceted effects on
glucose regulation , including improvement of
insulin sensitivity , increase of
insulin secretion , reduction of hepatic
insulin clearance , and reduction of
systemic inflammation . -
pubmed
Letter to the editor : " Comment on : Application of the optimized
carbon monoxide rebreathing method for the measurement of total
haemoglobin mass in
chronic liver disease " . -
pubmed
Synovial sarcoma ,
malignant peripheral nerve sheath tumor (
MPNST ) , and
pleuropulmonary blastoma also express
CD56 . -
pubmed
Pharmacokinetic samples , peripheral blood
CD56 - positive cell counts , and
tumor CD56 expression were assessed . -
pubmed
Five
patients experienced 9 dose - limiting
toxicities :
hyperglycemia ( n = 1 ) ,
colonic fistula ( n = 1 ) with
perforation ( n = 1 ) ,
nausea ( n = 1 ) with
vomiting ( n = 1 ) , increased
alanine aminotransferase in cycle 1 ( n = 2 ) , and increased
alanine aminotransferase in cycle 2 ( n = 1 ) with increased
aspartate aminotransferase ( n = 1 ) . -
pubmed
Increasing evidences indicate that in
Myotonic Dystrophy type 1 (
DM1 or
Steinert disease ) , an
autosomal dominant multisystem disorder caused by a ( CTG)n expansion in
DMPK gene on chromosome 19q13 . -
pubmed
Apolipoprotein A2 Isoforms : New Insight into the Risk of
Myocardial Infarction . -
pubmed
Further , the molecular interactions between
erythrin and the
diabetes related target proteins was established by analysing the interactions with associated
amino acids . -
pubmed
Analysis of
steatosis biomarkers and inflammatory profile after adding on
PCSK9 inhibitor treatment in
familial hypercholesterolemia subjects with
nonalcoholic fatty liver disease : A single lipid center real - world experience . -
pubmed
We aimed to evaluate the effect of the inhibitors of
proprotein convertase subtilisin / kexin type 9 (
PCSK9 - i ) on
steatosis biomarkers such as
triglyceride -
glucose index ( TyG ) and
hepatic steatosis index ( HSI ) and analyse the role of TG / HDL in this population before and after adding - on
PCSK9 - i. -
pubmed
METHODS AND RESULTS : In this observational study , we evaluated 26 genetically confirmed
FH patients with
NAFLD and an
LDL - C off - target despite high - intensity statins plus
ezetimibe . -
pubmed
No difference of
steatosis biomarkers was found after adding - on
PCSK9 - i therapy . -
pubmed
CONCLUSION : In conclusion ,
PCSK9 - i therapy significantly ameliorate
steatosis biomarkers in
FH patients with low TG /
HDL ; our results appear to be consistent with a beneficial role of
PCSK9 - i on
steatosis biomarkers in
FH subjects with
NAFLD . -
pubmed
Basolateral Amygdala Serotonin 2C Receptor Regulates
Emotional Disorder - Related Symptoms Induced by Chronic
Methamphetamine Administration . -
pubmed
Neuropharmacology and virus - mediated silencing strategies confirmed that targeting
5 - HT2CR reversed the
depressive and anxious behaviors induced by chronic
MA administration . -
pubmed
Thus , herein , for the first time , we report that the abnormal regulation of
5 - HT2CR is involved in the manifestation of
emotional disorder - like symptoms induced by chronic
MA use . -
pubmed
Our study suggests that
5 - HT2CR in the BLA is a promising clinical target for the treatment of
MA - induced
emotional disorders . -
pubmed
Sulfenylation of
Smad3 at
cysteine-64 inhibits its DNA binding activity , while mutation of this site attenuates the protective effects of
SO2 on
angiotensin II - induced vascular remodeling and
hypertension . -
pubmed
Administration of 10(-9)-10(-7 ) mol / L ET caused dose - dependently severe
contracture of myocytes , increase in cytosolic
lactate dehydrogenase leakage and increase of cellular total
calcium . -
pubmed
Amplification of the
N - myc gene in
human neuroblastomas : tandemly repeated amplicons within homogeneously staining regions on different chromosomes with the retention of single copy gene at the resident site . -
pubmed
[ The effect of
elastase on
aminonucleoside nephrosis -- on renal vascular system ] . -
pubmed
In addition ,
elastase possibly inhibits this process and thereby protect glomeruli from
sclerosis . -
pubmed
The
patients were grouped according to time course of abnormal serum
alanine aminotransferase (
ALT ) levels into three categories ( chronic biochemical disease , biochemically resolved
chronic disease , and acute disease ) . -
pubmed
Viremia in two patients with normal
ALT level suggests that
hepatitis is not only caused by viral cytopathic effects , but also by immunologic reactions against virus - infected cells . -
pubmed
Clinically ,
leukopenia with
neutropenia and low plasma levels of
copper and
ceruloplasmin were seen in all cases . -
pubmed
ACTH and
cortisol production decreases , metabolism slows down and due to an
adrenal insufficiency for which the pituitary is responsible there are characteristic changes in the
cortisol - dependent metabolic processes . -
pubmed
[ Clinical use of
bromelain ( Ananase ) in
chronic rhino - sinusitis ] . -
pubmed
[
Thyroid acetylcholinesterase in
thyrotoxicosis and
goiter ] . -
pubmed
The positive margin rate was not increased after reevaluation with
cytokeratin ,
PSA and
prostatic acid phosphatase immuno - staining but of 4 cases initially staged as P0 on
hematoxylin and eosin evaluation 2 had microscopic foci of
cancer with
prostatic acid phosphatase staining . -
pubmed
The initial rapid decrease in
PSA results from cessation of
androgen regulated
PSA synthesis and apoptosis , while the ongoing slower decrease reflects decreasing
tumor volume . -
pubmed
IGFBP-3 is a poor parameter for assessment of clinical activity in
acromegaly . -
pubmed
OBJECTIVE : Elevated
serum IGF - I and
IGF binding protein-3 (
IGFBP-3 ) levels have been found in
patients with active
acromegaly . -
pubmed
MEASUREMENTS : Twenty - four - hour sampling for
serum GH in
patients with
acromegaly ,
serum IGF - I and
IGFBP-3 . -
pubmed
RESULTS : Mean
IGF - I levels were 22.0 nmol / l ( range 6.5 - 38.4 ) in the healthy
adults and 118.7 nmol / l ( range 67.7 - 206.0 ) in
patients with
acromegaly . -
pubmed
Mean
IGFBP-3 levels were 3.5 mg / l ( range 2.1 - 4.8 ) in controls and 5.4 mg / l ( range 4.2 - 6.6 ) in
patients with
acromegaly . -
pubmed
Mean
IGF - I /
IGFBP-3 ratios were 6.5 nmol / mg ( range 1.9 - 14.5 ) in the healthy
adults and 22.0 nmol / mg ( range 14.3 - 32.7 ) in
patients with
acromegaly . -
pubmed
There was a considerable overlap for
IGFBP-3 levels but not for
IGF - I levels , between normals and
acromegalics . -
pubmed
The
IGF - I /
IGFBP-3 ratio also showed overlap between normals and
acromegalics . -
pubmed
There was a significant correlation between the mean 24 - hour
GH and
IGFBP-3 levels ( P = 0.036 ) and between the
IGF - I and
IGFBP-3 levels ( P & lt ; 0.002 ) in
acromegaly . -
pubmed
In
patients with
acromegaly , the
IGFBP-3 levels showed a decrement , but the
IGF - I /
IGFBP-3 ratio did not change significantly with age . -
pubmed
CONCLUSIONS :
IGFBP-2 has no additional discriminatory value over
IGF-1 measurements for the assessment of clinical activity in
acromegaly . -
pubmed
In
acromegaly ,
IGFBP-3 decreases with increasing age . -
pubmed
In
acromegaly ,
IGFBP-3 levels significantly correlate with mean 24 - hour
GH levels and
IGF - I levels . -
pubmed
The contribution of each methodology in clarifying the extent of involvement of
DGR in
esophageal mucosal injury is reviewed . -
pubmed
An inherited dysfunctional
fibrinogen variant , denoted as
fibrinogen Milano III , was found in a 13 - year - old
girl suffering from recurrent
venous thrombosis . -
pubmed
Radicicol , a
protein tyrosine kinase inhibitor , suppresses the expression of
mitogen - inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental
glomerulonephritis . -
pubmed
Radicicol also inhibited
COX-2 expression in vivo in glomeruli of
rats with experimental
glomerulonephritis induced by the anti - glomerular basement membrane antibodies , in which
COX-2 expression is known to be enhanced . -
pubmed
Pulmonary expression of
ICAM-1 and
LFA-1 in experimental
Goodpasture ' s syndrome . -
pubmed
The functional importance of
ICAM-1 and its ligands , the
beta 2 - integrins , in leukocytic accumulation in
pulmonary injury has been recently demonstrated in experimental models of
lung disease . -
pubmed
In the current study we have used immunogold ultrastructural techniques to define the precise location of
ICAM-1 in the lung and its interaction with
beta 2 - integrin expressing leukocytes in the early stages of experimental
Goodpasture ' s ( GP ) syndrome in the
rat . -
pubmed
In
GP syndrome there is an increase in
ICAM-1 expression , which is still confined to the alveolar type I epithelial cells and capillary endothelium . -
pubmed
Cytologic examination and
carcinoembryonic antigen assay of fine needle aspirates of
bone tumors . -
pubmed
A prospective study of 28 consecutive fine needle aspirates of bone was conducted comparing the sensitivities of cytologic diagnosis with
carcinoembryonic antigen (
CEA ) content to determine if the
CEA assay could enhance the sensitivity of cytologic diagnosis of
carcinoma metastatic to bone . -
pubmed
Mean
CEA and sensitivity were highest for
adenocarcinoma of lung ( 361.5 ng / mL , 77 % ) , lowest for
carcinoma of breast and negative for
lymphoma ,
myeloma and benign aspirates . -
pubmed
High
CEA was useful in ( 1 ) suggesting
adenocarcinoma of lung in
patients with an unknown primary , ( 2 ) suggesting a new primary
lung adenocarcinoma in a
patient with previous
transitional cell carcinoma of bladder , and ( 3 ) discriminating
lung adenocarcinoma from
adenocarcinomas of kidney , thyroid , prostate or endometrium . -
pubmed
An immunohistochemical study of
opsin in photoreceptor cells following light - induced
retinal degeneration in the
rat . -
pubmed
Light - induced
retinal degeneration has been hypothesized to be
rhodopsin - mediated . -
pubmed
We used light and
electron immunohistochemistry to study the alterations in
retinal opsin immunoreactivity in a
rat model of
retinal photic injury . -
pubmed
It appears that , despite severe light - mediated
retinal degeneration ,
anti - opsin immunoreactivity persisted in the photoreceptor cells but with an altered pattern in damaged rod outer segments and photoreceptor perikarya . -
pubmed
Anemia and
neutropenia are generally caused by inadequate production because of suppression of the bone marrow by the
HIV infection through abnormal
cytokine expression and alteration of the bone marrow microenvironment . -
pubmed
Supportive care for
anemia includes the use of
erythropoietin in addition to the judicious use of red blood cell transfusions . -
pubmed
Therapy for
neutropenia includes the use of the
myeloid growth factors G - CSF and
GM - CSF . -
pubmed
Products from mast cells influence T lymphocyte proliferation and
cytokine production -- relevant to
allergic asthma ? -
pubmed
It is hypothesized that this might be a negative feed back mechanism operating in allergic subjects , by which the Th2 - driven
IgE production and
eosinophilia are counteracted . -
pubmed
Insulin sensitivity was evaluated using an
insulin suppression test in 40 newly diagnosed
patients with
coronary artery disease and no previous history of
metabolic disorders , who were not taking any medication which might affect
insulin sensitivity . -
pubmed
The
insulin suppression test consisted of a constant infusion of
glucose ,
insulin and
somatostatin for 150 min ;
insulin resistance was estimated by determining the steady - state plasma
glucose concentrations during the last 60 minutes of the test . -
pubmed
We conclude that
captopril and , to a lesser extent ,
diltiazem improve
insulin sensitivity in
patients with stable
coronary artery disease . -
pubmed
The role of
protein kinase C activation in the pathogenesis of
diabetic vascular complications . -
pubmed
Many
vascular diseases in
diabetes are known to be associated with the activation of the
diacylglycerol ( DAG )- protein kinase C (
PKC ) pathway . -
pubmed
Among the various
PKC isoforms , the beta - isoform has been shown to be persistently activated in
diabetic animals . -
pubmed
Multiple lines of evidence have shown that many vascular alterations in
diabetes -- such as a decrease in the activity of
Na +- K +- adenosine triphosphatase (
Na +- K +- ATPase ) , and increases in extracellular matrix ,
cytokines , permeability , contractility , and cell proliferation -- are caused by activation of
PKC . -
pubmed
Inhibition of
PKC by two different kinds of
PKC inhibitors ,
LY333531 , a selective
PKC - beta - isoform inhibitor , and
d - alpha - tocopherol , were able to prevent or reverse the various
vascular dysfunctions in
diabetic rats . -
pubmed
These results have also provided in vivo evidence that
DAG -
PKC activation could be responsible for the
hyperglycemia - induced
vascular dysfunctions in
diabetes . -
pubmed
Clinical studies are now being performed to clarify the pathogenic roles of the
DAG -
PKC pathway in developing
vascular complications in diabetic
patients . -
pubmed
The impact of the vascular pathology on the evolution of tissue
fibrosis is not known ; still ,
cytokines (
TGFbeta ,
IL4 ) ,
vascular factors (
endothelin ) , and
growth factors (
PDGF ) are possibly crucial signals that link the
vascular disease to tissue
fibrosis . -
pubmed
Directional
transneuronal infection by
pseudorabies virus is dependent on an
acidic internalization motif in the
Us9 cytoplasmic tail . -
pubmed
A syndrome of acquired glucocorticoid resistance has been described in patients with
HIV with
hypercortisolism and a lower affinity of the
glucocorticoid receptors . -
pubmed
CD55 is over - expressed in the
tumour environment . -
pubmed
791Tgp72 is an antigen which has been used successfully as a target for both
tumour imaging and
cancer vaccines . -
pubmed
Quantitative expression of
CD55 in the
tumour environment was therefore studied . -
pubmed
Tumour cells showed a 4 - 100 - fold increase in
CD55 cell surface expression when compared to normal cells . -
pubmed
Immunohistochemical staining of colorectal
tumours also revealed high expression of
CD55 in the stroma . -
pubmed
Tumour cell lines deposit
CD55 into their extracellular matrix ( ECM ) in direct proportion to their cell surface expression . -
pubmed
Although it remains unclear why
CD55 is upregulated in the
tumour environment its high level of expression on
tumour cells and associated endothelium may explain why it is a good target for both imaging and immunotherapy . -
pubmed
Expression and clinical significance of the
G1 - S modulators in
intrahepatic cholangiocellular carcinoma . -
pubmed
OBJECTIVE : To elucidate the clinical roles of
G1 - S modulators in
cholangiocellular carcinoma (
CCC ) . -
pubmed
METHODS : We performed immunohistochemistry using antibodies against the
retinoblastoma gene product (
pRb ) ,
p16 ,
p21 ,
p27 ,
p53 and
cyclin D1 for 41 cases of
CCC as well as
normal bile ducts . -
pubmed
RESULTS : The
p27 labeling index ( LI ) was significantly higher in cases without lymph node metastasis than in
normal bile ducts , but it decreased greatly in cases with lymph node metastasis . -
pubmed
CONCLUSIONS : These results suggest that in
CCC : ( 1 )
p27 expression reflects the biological character of the
carcinoma and may regulate its progression ; ( 2 )
cyclin D1 plays a crucial role in cell cycle progression , and ( 3 ) aberrant
p53 expression has some effect on CCC cell proliferating activity . -
pubmed
Concomitant use of
clarithromycin or other potent inhibitors of
CYP3A4 with
repaglinide may enhance its blood
glucose - lowering effect and increase the risk of
hypoglycemia . -
pubmed
We , therefore , compared the
infarct : risk volume ratio ( I : R% ) after 30 - min global
ischemia in Langendorff - perfused hearts from outbred C57BL/6
mice with that in wild - type
mice derived from heterozygote
x heterozygote crosses of two different in - house C57BL/6 mouse lines with targeted disruption of an MKK3 or MAPKAPK2 allele . -
pubmed
Gastric intramucosal pH ( pHi ) ,
plasma endotoxin in portal vein , and plasma
D - lactic acid were measured and blood samples were cultured at different time intervals after
trauma . -
pubmed
[
Insulin - requiring
hypernephroma in a
diabetic ] . -
pubmed
Cloning of the
TSH receptor has led to marked progress in the understanding of the pathogenesis of
hyperthyroidism . -
pubmed
Genetic studies in familial cases of
Graves disease have allowed to dismiss the
TSH receptor as a candidate gene . -
pubmed
In cases of non immune
hyperthyroidism the implication of activating mutations of the
TSH receptor and of the a subunit of
Gs has been described . -
pubmed
Lessons from models of
SOD1 - linked familial
ALS . -
pubmed
Ten years ago , the linkage between mutations in the gene coding for the antioxidant enzyme
Cu ,
Zn superoxide dismutase (
SOD1 ) and the
neurodegenerative disease known as
familial amyotrophic lateral sclerosis (
FALS ) was established . -
pubmed
The cellular functions that are impaired in motoneurons as a consequence of molecular alterations induced by the expression of FALS
SOD1 converge on pathways that might be activated in
sporadic ALS by other toxic factors . -
pubmed
Increased
glutathione (
gamma - glutamylcysteinylglycine ;
GSH ) conjugation ( inactivation ) of alkylating anticancer drugs due to overexpression of cytosolic
glutathione S - transferase (
GST ) is believed to be an important mechanism in
tumor cell resistance to alkylating agents . -
pubmed
However , the potential involvement of microsomal
GST in the establishment of acquired drug resistance ( ADR ) to
CHB remains uncertain . -
pubmed
Loss of the tight junction protein
claudin 4 correlates with histological growth - pattern and differentiation in advanced gastric
adenocarcinoma . -
pubmed
It has been suggested that the loss of tight junction function is related to
tumor differentiation , but little is known about the roles of major proteins , such as
claudin 4 and
ZO-1 , in
gastric cancer . -
pubmed
The aims of this study were to examine the differences in expression of
E - cadherin ,
claudin 4 , and
ZO-1 proteins according to the pathological and clinical features of advanced
gastric cancer . -
pubmed
The expression of
E - cadherin ,
claudin 4 , and
ZO-1 was analyzed immuno - histochemically using
formalin - fixed , paraffin - embedded tissues obtained from 49
patients who underwent radical resection for advanced
gastric cancer . -
pubmed
Immunostaining for
E - cadherin ,
claudin 4 , and
ZO-1 was reduced in 69 , 69 , and 37 % of
cancers , respectively . -
pubmed
According to the Lauren classification , the reduced expression of
E - cadherin and
claudin 4 was more frequent in diffuse than intestinal type
tumors ( p<0.001 ) . -
pubmed
Western blot analysis and RT - PCR also showed decreased
claudin 4 expression in diffuse type
tumors and poorly - differentiated
adenocarcinoma . -
pubmed
The reduced expression of
claudin 4 and
E - cadherin correlates with disruption of glandular structure and loss of differentiation , which suggests that the dysfunction of
claudin 4 may play a role in the disruption of cell - to - cell adhesion in diffuse type
gastric cancer and in a loss of differentiation . -
pubmed
Administration of
leptin during pregnancy and lactation to these protein - restricted dams produces offspring that have increased metabolic rate and do not become
obese or
insulin resistant when fed on a high - fat diet . -
pubmed
Leptin administration to protein - restricted dams inhibits the suppression of
11beta - HSD-2 and may be one mechanism by which the
metabolic syndrome is prevented . -
pubmed
We now show that expression of constitutively active
beta - catenin in
normal lymphoid or myeloid progenitors generated uncommitted cells with multilineage differentiation potential . -
pubmed
Evidence of an association between
desmoglein 3 haplotypes and
pemphigus vulgaris . -
pubmed
BACKGROUND :
Pemphigus vulgaris (
PV , OMIM 169610 ) is a severe
blistering disorder of the skin and mucous membranes , caused by the production of autoantibodies directed against the epithelial adhesive protein
desmoglein 3 . -
pubmed
Although an association between
PV and
HLA class II alleles has been established , the genetic factors predisposing to the disease remain poorly understood , the rarity of
PV hampering the recruitment of substantial patient cohorts . -
pubmed
OBJECTIVES : To investigate
DSG3 as a candidate
PV susceptibility gene . -
pubmed
A related haplotype (
DSG3*TCCCC ) was associated with
PV in the Indian dataset ( P = 0.002 ) . -
pubmed
CONCLUSIONS : These results suggest that genetic variation of
DSG3 may be an additive risk factor predisposing to
PV and warrant further investigations of this gene . -
pubmed
Claudin-4 differentiates
biliary tract cancers from
hepatocellular carcinomas . -
pubmed
Certain
claudins have been shown to have relevance in
tumor development , with some of them , especially
claudin-4 , even suggested as future therapeutic target . -
pubmed
The aim of the present study was to analyze the expression of
claudin-4 in the biliary tree ,
biliary tract cancers and
hepatocellular carcinomas . -
pubmed
Intense membranous immunolabeling was found for
claudin-4 in all
biliary tract cancers unrelated to the primary site of origin , namely intrahepatic , extrahepatic or
gallbladder cancers . -
pubmed
Normal biliary epithelium showed weak positivity for
claudin-4 . -
pubmed
In contrast , normal hepatocytes and
tumor cells of
hepatocellular carcinomas did not express
claudin-4 . -
pubmed
Cytokeratins , as
CK7 ( 92 % ) and
CK19 ( 83 % ) were mostly positive in
biliary tract cancers , however , one - third of
hepatocellular carcinomas also expressed
CK7 ( 34 % ) . -
pubmed
HSA antibody (
HepPar1 ) reacted with the majority of hepatocellular
carcinomas ( 86 % ) , while being positive in a low percentage of the
biliary tract cancers ( 8 % ) . -
pubmed
In conclusion , this is the first report of a significantly increased
claudin-4 expression in
biliary tract cancers , which represents a novel feature of
tumors of biliary tract origin . -
pubmed
Claudin-4 expression seems to be a useful marker in differentiating
biliary tract cancers from
hepatocellular carcinomas and could well become a potential diagnostic tool . -
pubmed
CONCLUSION : The effects of Tongjiang granule on treating
GERD can be achieved by decreasing the
hydrochloric acid in gastric juice , increasing the
motilin in blood and promoting the gastric impetus in the
animal experiment . -
pubmed
PSA relapse ( median
PSA relapse - free survival , 10.3 years for radiotherapy vs 3.1 years for observation ; HR , 0.43 ; 95 % CI , 0.31 - 0.58 ; P<.001 ) and
disease recurrence ( median recurrence - free survival , 13.8 years for radiotherapy vs 9.9 years for observation ; HR , 0.62 ; 95 % CI , 0.46 - 0.82 ; P = .001 ) were both significantly reduced with radiotherapy . -
pubmed
CONCLUSIONS : In
men who had undergone radical prostatectomy for pathologically advanced
prostate cancer , adjuvant radiotherapy resulted in significantly reduced risk of
PSA relapse and disease recurrence , although the improvements in metastasis - free survival and overall survival were not statistically significant . -
pubmed
Polymorphisms in
methionine synthase reductase and
betaine - homocysteine S - methyltransferase genes : risk of
placental abruption . -
pubmed
We assessed whether polymorphisms in
MTRR ( 66A-->G ; I22 M ) and
BHMT ( 742G-->A ; R239Q ) were associated with
abruption . -
pubmed
CONCLUSIONS : In this population , there was an association between the homozygous mutant form of
BHMT ( 742G-->A ) polymorphism and increased risk for
placental abruption . -
pubmed
BACKGROUND : Intravenous immunoglobulin (
IVIG ) is increasingly being used to treat inflammatory and
autoimmune disease . -
pubmed
Angiotensin converting enzyme inhibitor but not
angiotensin receptor blockade or statin ameliorates
murine adriamycin nephropathy . -
pubmed
The
mice developed
albuminuria ,
renal insufficiency , and parenchymal
inflammation /
fibrosis accompanied by overexpression of intrarenal converting enzyme and
angiotensin II . -
pubmed
Angiotensin - converting enzyme inhibition confers renoprotection in
adriamycin nephropathy by reducing intrarenal
angiotensin II and augmenting Ac - SDKP expression that together attenuate
MAPK signaling and its downstream proinflammatory and fibrogenic properties . -
pubmed
PURPOSE :
Romidepsin (
FK228 ,
depsipeptide ,
FR901228 ) , a unique cyclic depsipeptide with a
histone deacetylase inhibitor (
HDACI ) activity , is a potential
cancer therapeutic agent and currently under clinical trials for several types of
cancer . -
pubmed
Our data indicate that
DMCA can potentiate the
HDACI activity of
romidepsin and other biological activities , such as cell cycle arrest and apoptosis ; these effects were accompanied with the expression of various key cell cycle regulators in different
bladder cancer cells . -
pubmed
CONCLUSIONS : a ) in the Italian population sexual dimorphism affects pre - natal thyroid migration but neither biochemical severity of
ectopia , nor pre - natal bone maturation and psychomotor development ; b )
girls with
CH do not require higher doses of initial therapy in order to achieve
TSH normalization ; c ) future developmental and molecular studies on
ectopia etiology in
CH need to take into account the effect of sexual dimorphism . -
pubmed
Changes in subcellular localisation of
MI - ER1 alpha , a novel
oestrogen receptor - alpha interacting protein , is associated with
breast cancer progression . -
pubmed
The
oestrogen receptor - alpha (
ER alpha ) plays a key role in breast development and tumorigenesis and inhibiting its activity remains a prime strategy in the treatment of
ER alpha - positive breast cancers . -
pubmed
Thus , elucidation of the molecular mechanisms responsible for regulating
ER alpha activity may facilitate the design of new , more effective
breast cancer therapies . -
pubmed
We investigated the ability of
MI - ER1 alpha to bind to
ER alpha in
HEK293 and
MCF-7 breast carcinoma cells , using co - immunoprecipitation assays . -
pubmed
Functional analysis revealed that overexpression of
MI - ER1 alpha in
T47D breast carcinoma cells results in inhibition of
oestrogen - stimulated anchorage - independent growth , suggesting that
MI - ER1 alpha may play a role in regulating
breast carcinoma cell proliferation in vivo . -
pubmed
No consistent difference in the
MI - ER1 alpha expression level between
normal breast tissue and
breast carcinoma was discernible . -
pubmed
However , there was a dramatic shift in the subcellular localisation : nuclear
MI - ER1 alpha was detectable in 75 % of
normal breast samples and in 77 % of
hyperplasia , but in
breast carcinoma , only 51 % of
DCIS , 25 % of
ILC and 4 % of
IDC contained nuclear staining . -
pubmed
This shift from nuclear to cytoplasmic localisation of
MI - ER1 alpha during
breast cancer progression suggests that loss of nuclear
MI - ER1 alpha might contribute to the development of invasive
breast carcinoma . -
pubmed
CONCLUSIONS : Transient
atrophy and regeneration were observed only in the GL , and the changes in the
MyHCIIb plus MyHCeom appeared to be related to these changes . -
pubmed
17 - AAG sensitized
malignant glioma cells to
death - receptor mediated apoptosis . -
pubmed
17 - AAG is a selective
HSP90 - inhibitor that exhibited therapeutic activity in
cancer . -
pubmed
In this study three
glioblastoma cell lines (
U87 ,
LN229 and
U251 ) were treated with
17 - AAG ,
tumor necrosis factor - related apoptosis - inducing ligand (
TRAIL ) or the combination of both . -
pubmed
Treatment with subtoxic doses of
17 - AAG in combination with
tumor necrosis factor - related apoptosis - inducing ligand (
TRAIL ) induces rapid apoptosis in
TRAIL - resistant
glioma cells , suggesting that this combined treatment may offer an attractive strategy for treating
gliomas . -
pubmed
In addition , over - expression of
survivin attenuated
cytotoxicity induced by the combination of
17 - AAG and
TRAIL . -
pubmed
In summary ,
survivin is a key regulator of
TRAIL-17 - AAG mediated cell death in
malignant glioma . -
pubmed
BACKGROUND / AIM : Viral eradication in
chronic hepatitis C patients with sustained virological response ( SVR ) after
interferon (
IFN ) therapy remains controversial . -
pubmed
CONCLUSION : This long - term study evaluating 157 patients demonstrated that SVR assessed by
TMA is durable , and
HCV antibodies were markedly decreased ( mainly those directed against the
non - structural proteins ) , emphasizing an absence of ongoing
infection . -
pubmed
These results support the concept that there is a race between the ability of a cell to detect and respond to
virus infection and the ability of a virus to block the
IFN response . -
pubmed
The diagnosis of
MNGIE disease can be established in a proband by detection of one of the following : ( 1 ) biallelic pathogenic variants in
TYMP ( formerly known as
ECGF1 ) ; ( 2 ) markedly reduced levels of
thymidine phosphorylase enzyme activity ; or ( 3 ) elevated plasma concentrations of
thymidine and
deoxyuridine . -
pubmed
GENETIC COUNSELING :
MNGIE disease is inherited in an autosomal recessive manner . -
pubmed
Unless an
individual with
MNGIE disease has offspring with either an affected individual or a carrier , his / her offspring will be obligate heterozygotes for a pathogenic variant in
TYMP . -
pubmed
After surgery , glycemic control is restored by a combination of enforced caloric restriction , enhanced
insulin sensitivity , and increased
insulin secretion . -
pubmed
Finally , as the long - lived
Fas protein remained stable during the early period of
infection , experiments with the
HSV-1 UL39 deletion mutant
ICP6 showed that
HSV-1 R1 could be essential for the protection of
HSV-1 - infected cells against
FasL. -
pubmed
In a study of sixty institutionalist
Schizophrenic patients , sixty
chronic schizophrenic outpatients and an equal number of age and sex matched normal controls from the same regional background , the prevalence of
HBsAG was six , one and zero respectively . -
pubmed
Two
patients ( 29 % ) harbored a known mutation in the
RASA1 gene , associated with a
hereditary vascular syndrome :
capillary malformation - arteriovenous malformation . -
pubmed
A 30 - kDa surface collagen binding protein
peroxiredoxin of
Entamoeba histolytica (
EhCBP30 ) was evaluated either alone or fused to the
chaperone (
CHP ) or
ATPase (
ATP ) domains of
heat shock protein 70 of
Trypanosoma cruzi ( TcHSP70 ) as a vaccine candidate in a
hamster model of experimental
amoebic liver abscess (
ALA ) development . -
pubmed
Partial agonist of
benzodiazepine receptors Ro 19 - 8022 elicits
withdrawal symptoms after short - term administration in immature
rats . -
pubmed
CONCLUSIONS : Findings lend support to a modulatory effect of common
OXTR variants on Harm Avoidance in healthy caucasian women and invite resequencing of the gene in
anxiety phenotypes to identify more explanatory functional variation . -
pubmed
Long - term efficacy of
insulin pump therapy in
children with
type 1 diabetes mellitus . -
pubmed
We evaluated the long - term efficacy of continuous
insulin infusion pump therapy ( CSII ) in pediatric
patients with
type 1 diabetes mellitus (
T1DM ) . -
pubmed
METHODS : This was a retrospective observational study which included 131
patients with
T1DM who transitioned to an
insulin pump from multiple daily
insulin ( MDI ) injections between 1999 and 2009 and were followed by one endocrinologist . -
pubmed
Previously , we found that afimbrial
adhesin gene (
afa)-positive motile DAEC strains isolated from patients with
diarrhoea induce high levels of
IL-8 secretion in
Caco-2 cells via
toll - like receptor 5 (
TLR-5 ) , while non - motile strains did not . -
pubmed
The aim of this study was to compare virulence properties , including the phylogenetic groups ,
afa subtypes ,
IL-8 secretion levels , and the effects on tight junctions , of DAEC strains isolated from healthy persons with those isolated from patients with
diarrhoea . -
pubmed
These data indicate that in conditions relevant to epidermal
wound healing ,
LPA induces SOCE and
NFAT activation through
Orai1 channels and promotes cell migration through a
calcineurin /
NFAT2 - dependent pathway . -
pubmed
METHODS : The
CIA model was induced by intradermal injection of
bovine collagen type II emulsion from the tail of 40 healthy male
Wistar rats . -
pubmed
RESULTS : Compared with the model group , after the intervention of WJR , 222 differentially expressed genes were identified in
CIA rats , including 76 genes up - regulated ( such as
RatNP-3b and so on ) and 146 downregulated ( such as
Angptl 2 ,
Muc1 ,
bcl-2 , and so on ) . -
pubmed
The study of such cases emphasizes the complexity of genetic interactions that underlie the phenotype of beta - thal and highlight the importance of the regulation of
Hb F production in
beta - thal syndromes . -
pubmed
BACKGROUND : The
Interleukin 28B (
IL28B ) rs12979860 polymorphisms was recently reported to be associated with the
human T - cell leukemia virus type 1 ( HTLV-1 ) proviral load ( PvL ) and the development of the
HTLV-1 - associated myelopathy /
tropical spastic paraparesis (
HAM /
TSP ) . -
pubmed
CONCLUSIONS : Our study failed to support the previously reported positive association between the
IL28B rs12979860 polymorphisms and an increased risk of developing
HAM /
TSP in the Brazilian population . -
pubmed
We conclude that hormone (
tamoxifen ) therapy is a useful treatment for elderly postmenopausal
woman with
estrogen receptor - positive advanced
breast cancer . -
pubmed
We evaluate the effects of long - term
telmisartan therapy on
renal dysfunction ,
podocyte injury ,
inflammation , and
transforming growth factor - beta1 (
TGF - beta1)/
Smad , epithelial - mesenchymal transition ( EMT ) ,
mitogen - activated protein kinase (
MAPK ) ,
Rho - kinase , and cell - cycle progression pathway in the renal cortex of SHRSP fatty
rats . -
pubmed
CONCLUSION : Long - term
telmisartan therapy may improve
renal dysfunction ,
glomerulosclerosis ,
podocyte injury , and
inflammation associated with EMT ,
TGF - beta /
Smad ,
MAPK ,
Rho - kinase pathway in SHRSP fatty
rats . -
pubmed
Gene amplification and overexpression of
Aurora - C in
breast and prostate cancer cell lines . -
pubmed
Human aurora kinases are three highly conserved
serine / threonine kinases with regulatory function in chromosome alignment , chromosome segregation , and cytokinesis during cell cycle progression and their overexpression associates with malignant transformation and proliferation of
cancer cells . -
pubmed
We evaluated the expression of three
Aurora kinases by real - time RT - PCR in well - known
breast and prostate cancer cell lines . -
pubmed
At DNA level , only
Aurora - C showed gene amplification in
breast cancer cell lines ( p & lt ; 0.005 ) . -
pubmed
However , simultaneous supplementation with
quercetin ( 75 mg / kg ) attenuated the
toxicity induced by PNP through renewal of the antioxidant enzyme 's status , alleviating apoptosis by regulating the expressions of
Bax and
Bcl - xl ,
XBP-1 and
HO-1mRNAs , and the regulation of
caspase-3 activity . -
pubmed
Towards achieving this goal , several researchers have carried out studies in various cell lines and in vivo and have deciphered that
fucoxanthin exerts its anti - proliferative and
cancer preventing influence via different molecules and pathways including the
Bcl-2 proteins ,
MAPK ,
NFkappaB ,
Caspases ,
GADD45 , and several other molecules that are involved in either cell cycle arrest , apoptosis , or metastasis . -
pubmed
Hemorheological parameters , such as WBV and
fibrinogen , and
AChE - RBC were ultimately proven to be useful biomarkers of the severity and progression of
AD patients . -
pubmed
Early - onset
cognitive deficits and
axonal transport dysfunction in P301S mutant
tau transgenic
mice . -
pubmed
Alzheimer ' s disease (
AD ) and
frontotemporal lobar degeneration (
FTLD ) are
neurodegenerative " tauopathies " characterized by hyperphosphorylated
tau accumulation and
neurofibrillary tangles . -
pubmed
The P301S mutation of
tau , a causal mutation of a familial type of
FTLD , is believed to be involved in neurodegenerative progression . -
pubmed
TPR50 mice demonstrated
cognitive dysfunction at 5 months . -
pubmed
Therefore ,
cognitive dysfunction in
TPR50 mice may result from early MT dysfunction and impaired axonal transport rather than accumulation of insoluble
tau and neurodegeneration . -
pubmed
TPR50 mice are a valuable new model to study progression of
tauopathies at both the behavioral and neurocellular levels and may also prove useful for testing new therapies for
neurodegenerative diseases . -
pubmed
Differential expression of
ETS family transcription factors in
NCCIT human embryonic carcinoma cells upon
retinoic acid - induced differentiation . -
pubmed
To identify critical ETS factor(s ) in germ cell - derived
cancer cells , we examined the expression patterns of the 27
ETS transcription factors in naive and differentiated
NCCIT human embryonic
carcinoma cells , which exhibit both pluripotent and tumorigenic characteristics . -
pubmed
These data suggest that
PEA3 and
ESE-1 may play important roles in pluripotent and tumorigenic embryonic
carcinoma cells . -
pubmed
A novel homozygous mutation in
ALS2 gene in four siblings with infantile - onset ascending
hereditary spastic paralysis . -
pubmed
Autosomal recessive early onset forms of
motor neuron disorders including infantile - onset ascending
hereditary spastic paraplegia ( OMIM # 607225 ) are due to homozygous mutations in the
ALS2 gene . -
pubmed
Here , we report on a novel splice - site mutation of the
ALS2 ( c.2351 + 2C > A ) in four
children of a consanguineous union with infantile - onset ascending
hereditary spastic paraplegia . -
pubmed
When challenged with food deprivation , vehicle and
RAP - treated
rats responded with rebound
hyperphagia , suggesting that
RAP was not inhibiting compensatory responses to
weight loss . -
pubmed
The
TRPV1 functional channel is the most investigated
TRP channel in these tissues , owing to its contribution to maintaining tissue homeostasis as well as eliciting
wound healing responses to injury . -
pubmed
Integrative investigation on
breast cancer in
ER ,
PR and
HER2 - defined subgroups using mRNA and miRNA expression profiling . -
pubmed
Here we have explored the intrinsic differences among
breast cancer subgroups defined by immunohistochemical expression ( IHC ) of hormone receptors
ER and
PR as well as
human epidermal growth factor receptor 2 (
HER2 ) using the mRNA and miRNA expression profiles of 115
tumors . -
pubmed
This study contributes to elucidating the intrinsic relations among
breast cancer subgroups defined by
ER ,
PR and
HER2 expression via integrating mRNA and miRNA expression . -
pubmed
Characterization of
JNJ-42847922 , a Selective
Orexin-2 Receptor Antagonist , as a Clinical Candidate for the Treatment of
Insomnia . -
pubmed
Analysis of variance ( ANOVA ) and Tukey 's test were used to verify any differences in
creatinine levels and estimated clearance at 0 , 6 , 12 , 24 and 36 months , adjusting for the co - variables sex , skin color , age & gt;50 years ,
arterial hypertension ,
diabetes and the use of the
ritonavir - boosted
protease inhibitors ( PI / r )
lopinavir / r or
atazanavir / r. The software package STATISTICA 10 ( ) was used for statistical analysis . -
pubmed
Nurse - led titration of
angiotensin converting enzyme inhibitors , beta - adrenergic blocking agents , and
angiotensin receptor blockers for
people with
heart failure with reduced ejection fraction . -
pubmed
Beta - adrenergic blocking agents ,
angiotensin converting enzyme inhibitors ( ACEIs ) , and
angiotensin receptor blockers ( ARBs ) can improve survival and reduce hospital readmissions and are recommended as first - line therapy in the treatment of
heart failure . -
pubmed
Expression of
scavenger receptor A in
rat 's liver tissue during
acute obstructive cholangitis and its significance . -
pubmed
Our aim was to investigate the expression of
scavenger receptor A (
SRA ) in
rat 's liver tissue during AOC and its relation with the inflammatory mediators and
hepatic injury caused by endotoxins . -
pubmed
CONCLUSION : In AOC , the expression of
SRA in liver gradually decreased with progressive increase in level of plasma endotoxins and
hepatic injury suggesting its importance in the defense mechanism . -
pubmed
Interleukin-6 ,
MCP-1 ,
IP-10 , and
MIG are sequentially expressed in cerebrospinal fluid after
subarachnoid hemorrhage . -
pubmed
BACKGROUND :
Interleukin-6 (
IL-6 ) , an inflammatory cytokine , plays important roles in cerebrospinal fluid ( CSF ) after
subarachnoid hemorrhage (
SAH ) . -
pubmed
Chemokines are chemoattractant
cytokines that regulate trafficking of monocytes / macrophages and lymphocytes to sites of
inflammation . -
pubmed
However , no studies have been reported regarding the temporal expression of these
cytokines in CSF after
SAH . -
pubmed
FINDINGS : The concentrations of
IL-6 ,
monocyte chemoattractant protein-1 (
MCP-1 ) ,
interferon - gamma - inducible protein-10 (
IP-10 ) , and
monokine induced by
interferon - gamma (
MIG ) in the CSF of ten
patients with
SAH were measured using ELISA kits over a period of 14 days . -
pubmed
CONCLUSIONS : The present investigation demonstrated that increases in
IL-6 levels may induce the expression of
MCP-1 in CSF after
SAH , followed by increases in the expression of
IP-10 and
MIG . -
pubmed
Dynamic changes in the levels of these
cytokines may induce
inflammation and may be closely associated with the development of delayed
ischemic neurological deficits after
SAH . -
pubmed
ERAP1 also plays a role in angiogenesis , cell cycle progression and migration , events that are shared between
tumour cells and placenta formation . -
pubmed
Here we discuss the similarities between
tumour and extravillous trophoblast cells in their immune modulatory , invasion , migration and proliferation properties in the context of
ERAP1 and its role in establishment of
solid tumours and placenta formation . -
pubmed
GTSP1 expression in non - smoker and non - drinker
patients with
squamous cell carcinoma of the head and neck . -
pubmed
We studied the expression of
GTSP1 in
tumor and
non - tumor tissue samples from
patients with and without these risks to identify whether
GTSP1 expression differs according to exposure to carcinogens . -
pubmed
RESULTS :
GTSP1 expression was detected in the
tumors of both groups . -
pubmed
GTSP1 expression was higher in the
non - tumor margins of
SD patients ( p = 0.004 ) . -
pubmed
No differences in survival were observed according to
GTSP1 staining in
tumors and
non - tumor margins . -
pubmed
CONCLUSION : This study showed that
GTSP1 was expressed in
tumors of
HNSCC patients regardless of smoking , drinking or
HPV infection status . -
pubmed
The difference in
GTSP1 expression in
non - tumor margins between the two groups may have been due to two possible reasons . -
pubmed
First , elevated
GTSP1 expression in
SD patients might be the result of activation of
GTSP1 in response to exposure to
carcinogens . -
pubmed
TOP2A and
EZH2 Provide Early Detection of an Aggressive
Prostate Cancer Subgroup . -
pubmed
Experimental Design : We have interrogated a total of seven primary
prostate cancer cohorts ( n = 1,900 ) , two metastatic castration - resistant
prostate cancer datasets ( n = 293 ) , and one prospective cohort ( n = 1,385 ) to assess the impact of
TOP2A and
EZH2 expression on
prostate cancer cellular program and patient outcomes . -
pubmed
We also performed IHC staining for
TOP2A and
EZH2 in a cohort of primary
prostate cancer patients ( n = 89 ) with known outcome . -
pubmed
Finally , we explored the therapeutic potential of a combination therapy targeting both
TOP2A and
EZH2 using novel
prostate cancer - derived murine cell lines . -
pubmed
Results : We demonstrate by genome - wide analysis of independent primary and metastatic
prostate cancer datasets that concurrent
TOP2A and
EZH2 mRNA and protein upregulation selected for a subgroup of primary and metastatic patients with more aggressive
disease and notable overlap of genes involved in mitotic regulation . -
pubmed
Importantly ,
TOP2A and
EZH2 in
prostate cancer cells act as key driving oncogenes , a fact highlighted by sensitivity to combination - targeted therapy . -
pubmed
Mutations in the TFIIH subunits
XPB ,
XPD , and
p8 lead to severe premature ageing and
cancer propensity in the
genetic diseases xeroderma pigmentosum ,
Cockayne syndrome , and
trichothiodystrophy , highlighting the importance of TFIIH for cellular physiology . -
pubmed
This review discusses the main vascular structural and functional abnormalities during physiological and premature aging , as well as the mechanisms involved in the exacerbated
CVD and accelerated aging induced by the accumulation of
progerin and
prelamin A. -
pubmed
Prostate Specific Antigen Density as a Predictor of Clinically Significant
Prostate Cancer When the Prostate Specific Antigen is in the Diagnostic Gray Zone : Defining the Optimum Cutoff Point Stratified by Race and Body Mass Index . -
pubmed
PURPOSE : We assessed the predictive value of
prostate specific antigen density to detect clinically significant
prostate cancer , defined as
prostate cancer grade group 2 or greater , in a series of men undergoing prostate biopsy with
prostate specific antigen 4 to 10 ng / ml . -
pubmed
We compared the AUC between
prostate specific antigen and
prostate specific antigen density to predict clinically significant and any
prostate cancer vs no
cancer . -
pubmed
Prostate specific antigen density improved the performance of prostate specific antigen to detect significant
cancer ( AUC 0.58 to 0.68 ) and any
cancer ( AUC 0.55 to 0.69 , each p & lt;0.001 ) . -
pubmed
This study was performed to investigate the efficacy of
HCQ therapy by serial assessment of disease activity and serum levels of proinflammatory
cytokines in
SLE patients . -
pubmed
RESULTS : Median levels of
IL-1beta ( p & lt ; 0.001 ) ,
IL-6 ( p = 0.001 ) , and
TNF - alpha ( p & lt ; 0.001 ) were significantly higher , whereas , median
CH50 level was significantly lower ( p & lt ; 0.001 ) in
SLE patients compared with controls . -
pubmed
CONCLUSION :
HCQ therapy is effective on clinical improvement of
SLE patients through interfering with inflammatory signaling pathways , reducing
anti - DNA autoantibodies and normalizing the complement activity . -
pubmed
Correlation between
RB1germline mutations and second primary
malignancies in
hereditary retinoblastoma patients treated with external beam radiotherapy . -
pubmed
Retinoblastoma (
Rb ) results from biallelic inactivation of the
RB1 gene . -
pubmed
Hereditary
Rb patients i. e germline carriers of a
RB1 mutation also have a risk of developing subsequent
malignant neoplasms (
SMN ) such as
osteosarcomas . -
pubmed
To decipher the relationship between
RB1 genotype and
SMN development in EBRT treated patients , we conducted a retrospective study in a cohort of 160 irradiated hereditary Rbs with fully resolved
RB1 mutational status . -
pubmed
We did n't find any difference in
RB1 mutation type between patients with or without
SMN , neither could we detect any linkage between mutation type and SMN location , SMN type and age at diagnosis . -
pubmed
Interestingly , among 13 carriers of a
RB1 low penetrance mutation , 3 of them developed
sarcomas , a rare
tumor that can not be attributed to the general population . -
pubmed
Our study can not explain why a
RB1 mutation leads or not to a SMN but demonstrated that EBRT patients with a low penetrance mutation remain at risk of
SMN and should be cautiously monitored . -
pubmed
half - marathon race ) to cause a defined quantity of lower body
muscle injury and a systemic inflammatory response lasting up to 24 h. Using a high - sensitivity , multiplex assay ( Milliplex ; Millipore - Sigma ) we were able to identify 9 of 21
cytokines that were significantly elevated at either 4 or 24 h post half - marathon performance . -
pubmed
Age , gender , the duration of admission , seasonal and monthly distribution of cases ,
diabetes and smoking status , white blood cell count , and
C - reactive protein (
CRP ) levels were recorded . -
pubmed
Diabetes status was not found to be associated with length of hospitalization and
CRP levels . -
pubmed
IPEC - J2 cells were pretreated with
puerarin ( 200 mug / mL ) ,
baicalin ( 1 mug / mL ) , and
berberine hydrochloride ( 100 mug / mL ) at 37 C for 3 h and then coincubated with the F4ac ETEC
bacterial strain 200 at 37 C for 3 h.
ETEC infection damaged the structure of
IPEC - J2 cells , upregulated
mucin 4 ( P & lt ; 0.01 ) and
mucin 13 mRNA ( P & lt ; 0.05 ) expression , increased the apoptosis rate ( P & lt ; 0.05 ) , and promoted inflammatory responses (
IL-6 and
CXCL-2 mRNA expression ) in
IPEC - J2 cells by activating the
nuclear factor - kappaB (
NF - kappaB ) signaling pathway . -
pubmed
Cadherins are homophilic cell - cell adhesion molecules whose aberrant expression has often been shown to correlate with different stages of
tumor progression . -
pubmed
Both ligands have been previously developed as mimics of the tetrapeptide sequence
Asp1 - Trp2 - Val3 - Ile4 of the
cadherin adhesion arm , and have been shown to inhibit
E - cadherin - mediated adhesion in epithelial
ovarian cancer cells with millimolar potency . -
pubmed
miR-454 - 3p exerts tumor - suppressive functions by down - regulation of
NFATc2 in
glioblastoma . -
pubmed
We found that
NFATc2 expression was significantly increased in both
GBM tissues and cultured cell lines . -
pubmed
Besides , expression levels of miR-454 - 3p were negatively associated with
NFATc2 expression in
GBM tissues . -
pubmed
NFATc2 knockdown in
GBM cells obviously inhibited cell proliferation and elevated apoptosis . -
pubmed
Suppression of
NFATc2 blocked the effects of miR-454 - 3p inhibitor on cell proliferation and apoptosis in
GBM cells . -
pubmed
The results indicated that miR-454 - 3p executed the tumor suppressive activity via downregulating
NFATc2 in
GBM . -
pubmed
Bromodomain and extraterminal domain inhibition synergizes with
WEE1 - inhibitor
AZD1775 effect by impairing nonhomologous end joining and enhancing DNA damage in
nonsmall cell lung cancer . -
pubmed
Bromodomain and extraterminal domain (
BET ) inhibitors are broadly active against distinct types of
cancer , including
nonsmall cell lung cancer (
NSCLC ) . -
pubmed
Thus , we hypothesized that
BET inhibition would increase
AZD1775 - induced
cytotoxicity by impairing DNA damage repair . -
pubmed
Here , we demonstrate that combined inhibition of
BET and
WEE1 synergistically suppresses
NSCLC growth both in vitro and in vivo . -
pubmed
Our findings reveal that
BET proteins , predominantly
BRD4 , play an essential role in DSB repair through the NHEJ pathway , and further suggest that combined inhibition of
BET and
WEE1 could serve as a novel therapeutic strategy for
NSCLC . -
pubmed
As such , decreased expression of either
GATA4 , 5 , or 6 results in impaired cardiovascular homeostasis and increased risk of premature and serious cardiovascular events such as
hypertension ,
arrhythmia ,
aortopathy , and
heart failure . -
pubmed
At the molecular level ,
hypoxia manifests its effects via activation of
HIF - dependent transcription . -
pubmed
p53 and
HIF-1alpha are known to share a mysterious relationship and play an ambiguous role in the regulation of
hypoxia - induced cellular changes . -
pubmed
This
p53 - induced chaperoning of
HIF-1alpha increases synthesis of HIF - regulated genes and thus the efficiency of
hypoxia - induced molecular changes . -
pubmed
DIAGNOSIS : Blood routine examination , erythrocyte sedimentation rate ,
C - reactive protein , and magnetic resonance imaging ( MRI ) of the lumbar spine indicated lumbar
pyogenic spondylodiscitis . -
pubmed
Effect of
pemafibrate , a novel selective
peroxisome proliferator - activated receptor - alpha modulator (
SPPARMalpha ) , on urinary protein excretion in
IgA nephropathy with
hypertriglyceridemia . -
pubmed
This paper is the first to show that 12 months of
pemafibrate ( 0.1 mg daily ) administration in three drug - naive and mild
IgAN patients with variable
renal dysfunction and histopathology proven
IgAN decreased serum
triglyceride level and excretion of urinary protein and
liver - type fatty acid - binding protein with no change in estimated glomerular filtration rate ( eGFR ) . -
pubmed
Although sCr is a commonly accepted clinical standard ,
cystatin C (
CysC ) has shown superiority in assessment of renal function in disease states characterized by
muscle wasting . -
pubmed
CONCLUSIONS : The majority of patients initiated monotherapy treatment for
PAH , most often a
phosphodiesterase 5 inhibitor ( PDE5i ) . -
pubmed
Halving Time of
BCR -
ABL1 in
Chronic Myeloid Leukemia : Is It Better Than Day-90 Value - A Multicenter Study From South India . -
pubmed
BACKGROUND : The 90 - day
BCR -
ABL1 (
breakpoint cluster region - Abelson 1 ) level has been one of the accepted milestones for predicting the molecular response in
patients with
chronic myeloid leukemia (
CML ) . -
pubmed
Therefore , we tested the accuracy of the rate of decline of
BCR -
ABL1 in predicting the molecular response compared with the single 90 - day values in a retrospective cohort study of selected
cancer centers in south India . -
pubmed
METHODS AND MATERIALS :
Patients with chronic - phase
CML diagnosed from January 2013 to December 2018 , the serial
BCR -
ABL1 levels were estimated at 0 , 45 , and 90 days , 6 months , and 1 year . -
pubmed
CONCLUSIONS : The halving time of
BCR -
ABL1 appears promising as a predictor of the outcomes for
patients with
CML . -
pubmed
Inherited DNA mismatch repair (
MMR ) defects cause predisposition to
colorectal , endometrial , ovarian , and other cancers occurring in
Lynch syndrome (
LS ) . -
pubmed
Microsatellite and
MMR protein analysis stratified
LS -
BCs into
MMR - deficient (
dMMR , n = 11 ) and
MMR - proficient (
pMMR , n = 9 ) subgroups . -
pubmed
All but one dMMR
LS -
BCs were hypermutated ( > 10 non - synonymous mutations / Mb ; average 174 / Mb per
tumor ) and the frequency of
MMR - deficiency - associated signatures 6 , 20 , and 26 was comparable to that in
LS -
OC and
LS -
CRC . -
pubmed
In conclusion , somatic mutational signatures suggest that conventional
MMR status of
tumor tissues is likely to underestimate the significance of the predisposing
MMR defects as contributors to breast tumorigenesis in
LS . -
pubmed
BACKGROUND :
Tay - Sachs disease (
TSD ) , a type of
GM2 - gangliosidosis , is a progressive
neurodegenerative lysosomal storage disorder caused by mutations in the alpha subunit of the
lysosomal beta - hexosaminidase enzyme . -
pubmed
Recently , an early onset
Tay - Sachs disease mouse model , with genotype
Hexa-/-
Neu3-/- , was generated . -
pubmed
Behavioral tests demonstrated a high level of
anxiety , and age - dependent loss in both spatial learning and fear memory in
Hexa-/-
Neu3-/-
mice compared with that in the controls . -
pubmed
CONCLUSION : Altogether , our data suggest that
Hexa-/-
Neu3-/-
mice display a phenotype similar to
Tay - Sachs patients suffering from
chronic neuroinflammation triggered by GM2 accumulation . -
pubmed
Tree shrews developed
bleomycin - induced pulmonary
fibrosis with architectural distortion in parenchyma and widespread
collagen deposition . -
pubmed
Thus ,
TTP must be suspected in patients with
microangiopathic hemolytic anemia and
thrombocytopenia , and plasma therapy must be initiated as soon as possible after ordering the
ADAMTS13 test . -
pubmed
Quercetin administration diminished the exudate and degree of
inflammation in lamina propria of nasal and sinusal areas , parallel with the decreased secretion of
TNF - alpha ( 40.2 % reduction after the low dose of LPS , and 35.4 % reduction after the high dose of LPS ) and
IL-6 ( 21.4 % reduction after the low dose of LPS and 35.8 % reduction after the high dose of LPS ) . -
pubmed
Flow cytometrically , abdominal fluid lymphocytes were highly positive for
CD4 ,
CD5 ,
CD18 ,
CD45 , and
MHC II , consistent with
T cell lymphoma . -
pubmed
Previous studies have presented evidence of shared idiotypic antigenic determinants located within the variable ( VH ) region of the heavy chains of monotypic
IgMlambda and
IgGkappa isolated from the serum of an
individual patient , Bro , with
Waldenstrom macroglobulinemia . -
pubmed
Moreover , these findings extend the results of a previous study that has demonstrated the dual presence of
IgGkappa and
IgGlambda paraproteins within individual
myeloma plasma cells . -
pubmed
These findings may have a broad implication for the understanding of
surface and cytoplasmic Ig markers of neoplastic lymphoid cells in certain other
lymphoproliferative disorders . -
pubmed
The plasma
fibrinogen concentration is usually increased in
inflammatory disorders and is thought to contribute to the ESR elevation ,
6 - sulfanilamidoindazole induced
arthritis in
rats produces very high plasma
fibrinogen concentrations and increased blood viscosity but no change in ESR . -
pubmed
Pharmacological blockade of the action of
glutamate at the
N - methyl - D - aspartate ( NMDA ) receptor , ( the
glutamate receptor subtype principally involved in the
neurotoxic effects of the
amino acid ) provides a novel therapeutic approach to
cerebral ischaemia . -
pubmed
The effects of
NMDA receptor antagonists in
animal models of focal
cerebral ischaemia are uniquely consistent , viz , a marked reduction in the amount of irreversible
ischaemic damage irrespective of the species , the model of
cerebral ischaemia , when the
animals are sacrificed after the
ischaemic episode , whether
ischaemia is permanent or temporary and followed by reperfusion and which particular
NMDA antagonist was employed . -
pubmed
The data which are reviewed provide the basis for the current clinical evaluation of
NMDA receptor antagonists in
stroke and
head trauma . -
pubmed
[ Analysis of deletions in the
dystrophin gene by the multiplex amplification method in patients suffering from
Duchenne ' s muscular dystrophy ] . -
pubmed
Amyotrophic lateral sclerosis : thyroid and
prolactin hormone changes in
thyrotropin - releasing hormone therapy . -
pubmed
13
patients with
amyotrophic lateral sclerosis (
ALS ) were treated with intravenous infusion of
thyrotropin - releasing hormone (
TRH ) . -
pubmed
[ Simultaneous determination of
prostatic acid phosphatase and
prostate - specific antigen in
carcinoma of the prostate . -
pubmed
Interferon in
human infections with
St. - pubmed
Interferons and
viral infections . -
pubmed
Mice receiving a single subcutaneous injection of 5 micrograms
type IV or type I murine collagens , or
murine laminin in complete Freund 's adjuvant mount a delayed - type
hypersensitivity response characterized by a mononuclear cell infiltrate when challenged in the footpad with the sensitizing antigen . -
pubmed
A cell line derived from a
human fibrosarcoma produced
SP1 at rates exceeding that of the normal fibroblasts , but
PP5 production was not detected in the
fibrosarcoma . -
pubmed
Correlation of mean nuclear area with
estrogen receptor content in aspiration cytology of
breast carcinoma . -
pubmed
The serological diagnosis of virus
hepatitis A and B depends on the demonstration of the various virus antigens (
HA - antigen ,
HBs - antigen ,
HBe - antigen ) and on their corresponding antibodies (
HA- ,
IgG- and
IgM - antibody ,
HBc - antibody ,
Hbe - antibody and
HBs - antibody ) . -
pubmed
Prealbumin rather than
albumin is a more sensitive indicator of
acute liver disease . -
pubmed
The changes in
serum prealbumin (
transthyretin ) and
serum albumin in acute and chronic
liver diseases were investigated . -
pubmed
Albumin has long been used as a useful indicator of liver function but
serum prealbumin has recently been noted for its clinical significance in
acute liver diseases . -
pubmed
Serum prealbumin concentrations and liver function tests (
albumin ,
bilirubin ,
alanine aminotransferase ) were determined on blood obtained from normal
donors ( n = 148 ) and from
patients suffering from
liver diseases ( n = 78 ) such as acute
viral hepatitis ,
chronic active hepatitis ,
cirrhosis and
hepatoma . -
pubmed
The mean
serum prealbumin concentration in normal
subjects was 29.6 + /- 4.82 mg / dl while the mean
serum prealbumin concentration in
patients with
liver disease was greatly reduced ( acute viral
hepatitis = 15.3 + /- 7.4mg / dl ;
chronic active hepatitis = 10.2 + /- 6.6mg / dl ;
cirrhosis = 9.9 + /- 6.4mg / dl and
hepatoma = 10.7 + /- 4.2 ) . -
pubmed
Albumin concentrations dropped slightly ( 13 % compared to control ) in
acute viral hepatitis but dropped markedly ( 28 % compared to control ) in
chronic liver diseases . -
pubmed
The study suggests that
serum prealbumin concentration might be a more sensitive indicator than
albumin in assessing
liver dysfunction in
acute liver diseases . -
pubmed
Coexpression of
IL-2 and
gamma - IFN enhances
tumor immunity . -
pubmed
Relation between blood pressure and hematocrit in
anephric patients treated by means of
recombinant DNA human erythropoietin . -
pubmed
When different categories of
obesity are compared , blood pressure and one or more of the lipids show an increasing trend but
glucose or
insulin level shows no significant change . -
pubmed
Immunoblot analysis , using epidermal extract of normal
human skin , revealed that these
patients ' sera reacted only with
bullous pemphigoid antigen with a molecular weight of 180 kDa (
BP180 ) . -
pubmed
The relationship of
BP180 to
malignant tumours is discussed . -
pubmed
BACKGROUND / AIMS : Knockout
mice lacking
mdr2 , the
murine analogue of
human MDR3 P - glycoprotein , develop
chronic non - suppurative cholangitis . -
pubmed
Recently , a deficiency in
MDR3 messenger RNA ( mRNA ) has been reported in a subtype of progressive
familial intrahepatic cholestasis . -
pubmed
Thus , reduced
MDR3 gene expression could be involved in
human cholestatic liver diseases . -
pubmed
Using this method we determined the
MDR3 mRNA levels in 52 liver specimens from
primary biliary cirrhosis ( n=11 ) ,
chronic hepatitis B ( n=5 ) ,
chronic hepatitis C ( n=14 ) ,
non - cholestatic cirrhosis ( n=9 ) and controls ( n=13 ) . -
pubmed
CONCLUSIONS : We found no evidence for deficient or severely reduced intrahepatic
MDR3 mRNA in primary
biliary cirrhosis , nor were mRNA levels altered significantly by virus - induced
inflammation or by
cirrhosis . -
pubmed
Why do so many
cancer patients fail to respond to
interferon therapy ? -
pubmed
Since their first use in the clinic some 25 years ago ,
interferons (
IFNs ) have become accepted therapy in a range of
cancer forms . -
pubmed
[ The structure of the connective - tissue framework of the skin regenerate in
rats during the
trypsin and
ronidase stimulation of
wound healing ] . -
pubmed
Formation of granulation tissue and
scar was accelerated after daily 20 minutes treatment with 0.2 %
trypsin and 0.1 % ronidase solutions as compared to that in control . -
pubmed
Prior to the discovery in 1993 and 1994 of genes (
hMSH2 ,
hMLH1 ,
hPMS1 ,
hPMS2 ) known as mis - match repair genes or mutator genes , the diagnosis of
HNPCC rested exclusively upon evaluation of clinical findings in concert with a well - documented and extended pedigree . -
pubmed
This study was designed to determine whether the force - frequency effect on myocardial contractility , known to be importantly regulated by the adrenergic nervous system in experimental
animals , can be enhanced by
beta - adrenergic receptor stimulation in
patients with
heart failure . -
pubmed
To investigate the role of
Esp proteins in disease , mutations in
espA and
espB were constructed in
rabbit EPEC serotype O103 and infection characteristics were compared to that of the wild - type strain using histology , scanning and transmission electron microscopy , and confocal laser scanning microscopy in a weaned
rabbit infection model . -
pubmed
Collectively , this study shows for the first time that the type III secreted proteins
EspA and
EspB are needed to form A / E
lesions in vivo and are indeed virulence factors . -
pubmed
Using the
AOS cDNA from
tomato (
Lycopersicon esculentum ) , in which the role of
jasmonic acid in
wound - induced defense gene activation has been best described , we examined the kinetics of
AOS induction in response to wounding and elicitors , in parallel with that of the wound - inducible
PIN II (
proteinase inhibitor II ) gene . -
pubmed
The addition of
silver thiosulfate , an
ethylene action inhibitor , prevented the
wound - induced expression of both
AOS and
PIN II . -
pubmed
C - reactive protein was revealed as appropriate for diagnosis and follow - up of
spondylitis . -
pubmed
Gonadotropin - releasing hormone (
GnRH)-antagonists can suppress the pituitary hormone secretion completely within a few hours , allowing the avoidance of premature luteinization within controlled
ovarian hyperstimulation ( COH ) for assisted reproductive technologies ( ART ) by midcycle administration . -
pubmed
Without any doubt
GnRH - antagonists have the potential to become the new standard for controlled
ovarian hyperstimulation . -
pubmed
Unfavorable
HL was defined as the presence of at least two of the following poor prognostic factors : high
lactate dehydrogenase level , large mediastinal mass ( greater than at least 33 % of the thoracic diameter ) , more than one extranodal site , low hematocrit level , and inguinal involvement . -
pubmed
We report on such
apyrase - mediated allele - specific primer extension ( AMASE ) assay as a method suitable for high - throughout resequencing and mutation detection in
tumor suppressor genes and oncogenes . -
pubmed
CONCLUSION : Clinicians should consider NSAID use in the differential diagnosis of
lithium toxicity , monitor
patients ' serum
lithium concentrations during the initiation or discontinuation of NSAID therapy , and be aware that the selective
COX-2 inhibitors can increase serum
lithium concentrations leading to toxicity . -
pubmed
Because
SP - D specifically interacts with neutrophils that infiltrate the lung in response to
acute inflammation and
infection , we examined the hypothesis that the
neutrophil - derived serine proteinases (
NSPs ):
neutrophil elastase ,
proteinase-3 , and
cathepsin G degrade
SP - D. -
pubmed
Using a
mouse model of acute
bacterial pneumonia , we observed the accumulation of
SP - D at sites of neutrophil infiltration coinciding with the appearance of approximately 35 - kDa
SP - D fragments in bronchoalveolar lavage fluids . -
pubmed
Together , our data suggest that
neutrophil - derived serine proteinases cleave
SP - D at sites of
inflammation with potential deleterious effects on its biological functions . -
pubmed
Decreased expression of
killer cell inhibitory receptors on natural killer cells in eutopic endometrium in women with
adenomyosis . -
pubmed
BACKGROUND : Increased expression of
killer cell inhibitory receptors (
KIRs ) has been found on natural killer ( NK ) cells in peritoneal fluid in women with
endometriosis . -
pubmed
In this study , we tried to measure the expression of
KIRs on NK and T cells in
women with
adenomyosis , in an attempt to find the possible role of
KIRs in the development of
adenomyosis . -
pubmed
RESULTS : There was a decreased expression of
NKB1 and
GL183 on NK cells in the endometrium , but not in the myometrium , in women with
adenomyosis . -
pubmed
However , the expression of
KIRs on T cells , either
CD4 + or CD8 + , was not different in either myometrium or endometrium between women with and without
adenomyosis . -
pubmed
CONCLUSIONS : The expression of
KIRs on NK cells was decreased in eutopic endometrium in
women with
adenomyosis . -
pubmed
[ Hepatocyte apoptosis and the expression of
Bcl-2 and
Bax in
Yin - jaundice rats ] . -
pubmed
OBJECTIVE : To investigate the effects of Yinchen Shufu Decoction on hepatocyte apoptosis and the expression of its apoptosis - regulating gene
Bcl-2 and
Bax in
Yin - jaundice rats . -
pubmed
RESULTS : The rate of apoptosis cells in
Yin - jaundice model group was higher significantly than that in Yang -
jaundice model group and normal control group ( P<0.01 ) , the expression of
Bcl-2 in Yinchen Shufu Decoction treatment group was higher significantly than that in Yin -
jaundice model group ( P<0.01 or P<0.05 ) , and the expression of
Bax in it was lower significantly than that in Ying -
jaundice model group ( P<0.01 or P<0.05 ) . -
pubmed
Erythrocyte
glutathione and serum total
glutathione - S - transferase in
epilepsy . -
pubmed
The
metabolic syndrome was defined according to the National
Cholesterol Education Program definition , and
insulin sensitivity was calculated by use of the quantitative
insulin sensitivity check index . -
pubmed
RESULTS : Multiple logistic regression analyses showed an inverse relationship according to 1 sd increase for circulating TT [ odds ratio ( OR ) = 0.43 ; 95 % confidence interval ( CI ) , 0.32 - 0.59 ] , BT ( OR = 0.62 ; 95 % CI , 0.46 - 0.83 ) ,
SHBG ( OR = 0.46 ; 95 % CI , 0.33 - 0.64 ) , and
DHEA - S ( OR = 0.76 ; 95 % CI , 0.56 - 1.02 ) with the
metabolic syndrome . -
pubmed
Linear regression analyses showed that higher TT , BT , and
SHBG levels were related to higher
insulin sensitivity ; beta - coefficients ( 95 % CI ) were 0.011 ( 0.008 - 0.015 ) , 0.005 ( 0.001 - 0.009 ) , and 0.013 ( 0.010 - 0.017 ) , respectively , whereas no effects were found for
DHEA - S and E2 . -
pubmed
Further adjustment for
insulin levels and body composition measurements attenuated the estimates , and the associations were similar in the group free of
cardiovascular disease and
diabetes . -
pubmed
CONCLUSIONS : Higher
testosterone and
SHBG levels in aging males are independently associated with a higher
insulin sensitivity and a reduced risk of the
metabolic syndrome , independent of
insulin levels and body composition measurements , suggesting that these hormones may protect against the development of
metabolic syndrome . -
pubmed
MSH6 mutations and risk of
uterine cancer . -
pubmed
The anticonvulsant potency of the competitive antagonist of the
N - methyl - D - aspartate ( NMDA ) receptor ,
2 - amino-7 - phosphonoheptanoic acid (
APH ) was investigated in the model of
epilepsy induced by systemic administration of
metaphit (
1 -( 1 -( 3 - isothiocyanatophenyl )- cyclohexyl )- piperidine ) . -
pubmed
PURPOSE OF REVIEW : We have selectively reviewed some of the latest papers on the mechanistic role of
C - reactive protein in
atherosclerotic cardiovascular disease . -
pubmed
The
atherosclerotic lesion itself is another place where
C - reactive protein could be produced . -
pubmed
The biological effect of
C - reactive protein on
atherosclerosis development seems to encompass a complex network of interactions with other players in immunity and
inflammation , such as the complement system , as well as a direct effect of
C - reactive protein on the cells involved in lesion growth and development . -
pubmed
The diagnosis of
ZES is certain when the
plasma gastrin is & gt;1000 pg / mL and the basal acid output is & gt;15 mEq / h in
patients with an intact stomach , & gt;5 mEq / h in gastrectomised
patients , or when the
hypergastrinemia is associated with a pH & lt;2 . -
pubmed
In conclusion , disruptions of the tight junctions observed in this study implicate host cell signaling pathways , including the phosphorylation of
myosin light chain and the regulation of tight - junctional proteins
claudin-4 and
claudin-5 , in the pathogenesis of
H. - pubmed
Chemokines direct endothelial progenitors into
tumor neovessels . -
pubmed
We unequivocally demonstrate integration of bone marrow cells into the
tumor vasculature as a late event in carcinogenesis that temporally correlates with
VEGF release by the
tumor and mobilization of circulating EPC in the periphery . -
pubmed
Moreover , we demonstrate a
chemokine - dependent mechanism of EPC homing into
tumor , whereby neovessels of late - stage
tumors release a battery of
CC chemokines , which direct
CCR2(+ ) and
CCR5(+ ) progenitors into the vasculature . -
pubmed
In this study , the relationship between PV replication in the spinal cord , damage in the motor neurons and
poliomyelitis - like
paralysis was analysed in transgenic
mice expressing the
human PV receptor (
TgPVR21 ) . -
pubmed
However , severe
paralysis could also be observed with an apparently low lesion score , where as few as 5.3 x 10(2 ) motor neurons ( 1.4 % of the susceptible cells in the lumbar cord ) were infected by TE -
PV - Fluc mc . -
pubmed
DNA methylation markers of
surfactant proteins in
lung cancer . -
pubmed
Normal lung tissues with a higher level of unmethylated
SP - A1_1468 and
SP - D_1170 CpG exhibited a higher level of
SP - A1 and
SP - D gene transcripts indicating that
CpG methylation may play a role in gene expression . -
pubmed
We speculate that
SP - A1 and
SP - D are subject to methylation / demethylation regulatory mechanisms and are involved in
lung cancer pathogenesis by virtue of their function in innate host defense and/or regulation of
inflammation . -
pubmed
Studies conducted with
cytokines and
diamide ( a
thiol - depleting agent ) confirmed that
cytokines are active agents in LCM which may be responsible for inhibition of OL development via
peroxisomal dysfunction and induction of oxidative stress . -
pubmed
Collectively , these data provide evidence that the modulation of
PPAR - alpha activity , thus peroxisomal function by
NAC attenuates LPS - induced glial factors - mediated inhibition of OL development suggesting new therapeutic interventions to prevent the devastating effects of
maternal infections . -
pubmed
Transforming growth factor beta1 T29C gene polymorphism and
hypertension : relationship with
cardiovascular and renal damage . -
pubmed
Distribution of T29C
TGFbeta1 gene polymorphism was analysed in 260
hypertensive and 134 normotensive subjects . -
pubmed
Circulating
TGFbeta1 and
procollagen type III levels ,
microalbuminuria , left ventricular geometry and function were evaluated in all the
hypertensives subgrouped according to T29C
TGFbeta1 gene polymorphism . -
pubmed
Circulating
TGFbeta1 by ELISA technique ,
procollagen type III by a specific radioimmunoassay ,
microalbuminuria by radioimmunoassay , left ventricular geometry and function by echocardiography were determined . -
pubmed
Regarding T29C
TGFbeta1 gene polymorphism , prevalence of
TC or CC genotypes was significantly ( p<0.05 ) higher in
hypertensives than normotensives . -
pubmed
TC and CC
hypertensives were characterized by a higher prevalence of subjects with
microalbuminuria ( p<0.001 TC vs TT ; p<0.05 CC vs TT ) ,
left ventricular hypertrophy ( p<0.01 TC and CC vs TT ) , and by increased levels of
procollagen type III ( p<0.05 TC and CC vs TT ) . -
pubmed
TC
hypertensives were also characterized by a significant increase ( p<0.05 ) of LVM and LVM / h(2.7 ) and of urinary
albumin excretion ( p<0.05 ) values than those detectable in TT
hypertensives . -
pubmed
Our data suggest that T29C
TGFbeta1 gene polymorphism was associated to clinical characteristics suitable to recognize
hypertensives with a higher severity of
hypertension . -
pubmed
This is important because virus and
tumor Ag - specific
CD4 T cell responses are selectively impaired in several
chronic viral infections and
malignancies . -
pubmed
Functional heterospecific memory CD4 T cells could also rescue secondary
CD8 T cell responses in an experimental
tumor model in which homospecific
CD4 help was impaired . -
pubmed
Co - culture with PZ stromal cells and
transforming growth factor - beta1 (
TGF - beta1 ) increased the
tumor growth of
PC-3 cells in vitro and in vivo , as well as
Bcl-2 expression . -
pubmed
Activation of
calpain-1 in
human carotid artery atherosclerotic lesions . -
pubmed
Our observation of autoproteolytic cleavage of the 80 kDa subunit of
calpain-1 provided further evidence for enzyme activity in the
plaque samples . -
pubmed
CONCLUSION : These novel results suggest that
calpain-1 is commonly active in
carotid artery atherosclerotic plaques , and that calpain activity is colocalized with cell death and inversely associated with symptoms . -
pubmed
To develop potential biomarkers for diagnosis , we have identified five novel genes (
CYP39A1 ,
GTF2A1 ,
FOXD4L4 ,
EBP , and
HAAO ) that are hypermethylated in
ovarian tumors , compared with the non - malignant
normal ovarian surface epithelia , using the quantitative methylation - specific polymerase chain reactions . -
pubmed
Tetrahydroxy stilbene glucoside reduces the
cognitive impairment and overexpression of
amyloid precursor protein induced by
aluminum exposure . -
pubmed
The present study aims to evaluate the effects of
tetrahydroxy stilbene glucoside (
TSG ) , the extract from herbal medicine
Polygoni Multiflori , on
cognitive impairment and the over - expression of
hippocampal amyloid precursor protein (
APP ) induced by chronic exposure to
Al in
rats . -
pubmed
c - Jun activation is required for
4 - hydroxytamoxifen - induced cell death in
breast cancer cells . -
pubmed
The
c - Jun N - terminal kinase (
JNK ) has been shown to mediate
tamoxifen - induced apoptosis in
breast cancer cells . -
pubmed
In this study , we analysed whether
c - Jun , the major nuclear target of
JNK , has a role in
tamoxifen - induced apoptosis of
SkBr3 breast cancer cells . -
pubmed
Furthermore , both
c - Fos expression and
c - Jun N - terminal phosphorylation preceded
OHT - dependent activation of
caspase 3 - 7 in different types of
tamoxifen - sensitive
cancer cells , but not in
OHT - resistant
LNCaP prostate cancer cells . -
pubmed
Taken together , our results indicate that the
c - Jun /
c - Fos AP-1 complex has a pro - apoptotic role in
OHT - treated
cancer cells and suggest that pharmacological boosts of
c - Jun activation may be useful in a combination therapy setting to sensitize cancer cells to
tamoxifen - mediated cell death . -
pubmed
Vaccination with TCL plus
MHSP65 induces
anti - lung cancer immunity in
mice . -
pubmed
Our results showed that
MHSP65 - TCL immunization significantly inhibited the growth of
lung cancer in
mice and prolonged the survival of
lung cancer bearing
mice . -
pubmed
In vivo and in vitro data suggest that
MHSP65 - TCL could induce specific CTL responses and non - specific immunity , both of which could contribute to the
tumor inhibition . -
pubmed
2 - Amino-3,8 - dimethylimidazo [ 4,5 - f ] quinoxaline (
MeIQx)-induced
hepatocarcinogenesis is not enhanced by
CYP1A inducers ,
alpha - and beta - naphthoflavone : relationship to intralobular distribution of
CYP1A expression . -
pubmed
Therefore , we here investigated the effects of
alpha - and beta - naphthoflavone as
CYP1A2 inducers on
MeIQx - induced
rat hepatocarcinogenesis in a medium - term
rat liver bioassay . -
pubmed
Unexpectedly , no modifying influence of
naphthoflavones on
MeIQx - induced
hepatocarcinogenesis was demonstrated with reference to
glutathione S - transferase placental form (
GST - P ) positive foci in the liver , although up - regulation of
CYP1A2 was detected on Western blot analysis . -
pubmed
TBI animals had an increase in intestinal
tumor necrosis factor - alpha 6 hours after
injury compared with vagal stimulation +
TBI ( 45.6 + /- 8.6 pg / mL vs. 24.1 + /- 1.4 pg / mL ; p & lt ; 0.001 ) . -
pubmed
TBI increased intestinal
GFAP 6.2 - fold higher than sham at 2 hours and 11.5 - fold higher at 4 hours after
injury ( p & lt ; 0.05 ) . -
pubmed
Intestinal
GFAP in vagal stimulation +
TBI animals was also 6.7 - fold higher than sham at 2 hours , however , intestinal
GFAP was 18.0 - fold higher at 4 hours compared with sham and 1.6 - fold higher than
TBI alone ( p & lt ; 0.05 ) . -
pubmed
Crizotinib for
EML4 -
ALK positive
lung adenocarcinoma : a hope for the advanced disease ? -
pubmed
Anaplastic lymphoma kinase inhibition in
non - small - cell lung cancer . -
pubmed
INTRODUCTION : In
lung adenocarcinoma , certain mutations such as
echinoderm microtubule - associated protein - like 4 - anaplastic lymphoma kinase (
ALK ) are associated with lower sensitivity to chemotherapy , when used conventionally as the first - line therapy in the advanced stage of the disease . -
pubmed
AREAS COVERED : This paper discusses the clinical and therapeutic importance of
ALK mutations in
NSCLC and the early clinical results of a Phase I study assessing
crizotinib in
patients with
ALK mutations . -
pubmed
EXPERT OPINION : Abnormal
ALK is evolving as an important therapeutic target in
patients with more aggressive
lung adenocarcinoma . -
pubmed
The activity of
thrombin is central to the processes of
fibrin generation and
platelet aggregation , which are inherent in
thrombus formation . -
pubmed
OBJECTIVE : To investigate the influence of
Drynaria total
flavonoids on proliferation and apoptosis of osteoblasts in
tumor necrosis factor - alpha (
TNF - alpha)- mediated medium , so as to explore the mechanism of
Drynaria total
flavonoids in preventing and treating
osteoporosis of
rheumatoid arthritis . -
pubmed
CONCLUSION : In
TNF - alpha - mediated inflammatory environment ,
Drynaria total
flavonoids can promote the proliferation and decrease the apoptosis of osteoblasts by improving the ratio of Bcl-2 mRNA to Bax mRNA , which may be one of the mechanisms of
Drynaria total
flavonoids in preventing and treating
osteoporosis of
rheumatoid arthritis . -
pubmed
Finally , our results show that mutations in
ATL1 causing
hereditary spastic paraplegia compromise homotypic
ER fusion . -
pubmed
CD44 variant regulates redox status in
cancer cells by stabilizing the
xCT subunit of system xc(- ) and thereby promotes
tumor growth . -
pubmed
CD44 is an adhesion molecule expressed in
cancer stem - like cells . -
pubmed
Human gastrointestinal cancer cells with a high level of
CD44 expression showed an enhanced capacity for
GSH synthesis and defense against reactive
oxygen species ( ROS ) . -
pubmed
Ablation of
CD44 induced loss of
xCT from the cell surface and suppressed
tumor growth in a
transgenic mouse model of
gastric cancer . -
pubmed
These findings establish a function for
CD44v in regulation of ROS defense and
tumor growth . -
pubmed
It plays an essential role during branching morphogenesis of the metanephric kidneys , as
mice with a targeted deletion of the
Fgfrl1 gene show severe
kidney dysplasia . -
pubmed
A blood cell type termed crystal cell in
Drosophila functions in clotting and
wound healing and requires
Notch for specification and maintenance . -
pubmed
This interaction initiates in early endosomes , is independent of
Hif - beta ( Tauangomicron in
Drosophila ) , and does not activate
hypoxia response targets . -
pubmed
It was recently reported that mutation of
CRY in
p53 - null
mice delayed the onset of
cancer . -
pubmed
It was therefore suggested that
CRY mutation may activate
p53 - independent apoptosis pathways , which eliminate premalignant and malignant cells and thus delay overt
tumor formation . -
pubmed
These findings provide a mechanistic foundation for the delayed onset of tumorigenesis in clock - disrupted
p53 mutant
mice and suggest unique therapeutic strategies for treating
cancers associated with
p53 mutation . -
pubmed
for positron emission tomography ( PET ) of
HER2 - expressing
tumors ( 1 ) . -
pubmed
The radiolabeled MUT - DS derivatives exhibited favorable pharmacokinetics for both imaging and therapy of
HER2 - expressing
tumors . -
pubmed
TLR2 /
MyD88 /
NF - kappaB pathway , reactive
oxygen species ,
potassium efflux activates
NLRP3 /
ASC inflammasome during
respiratory syncytial virus infection . -
pubmed
Interleukin-1beta (
IL-1beta ) plays an important role in
inflammation by orchestrating the pro - inflammatory response . -
pubmed
Although
RSV infection results in
IL-1beta release , the mechanism is unknown . -
pubmed
Here in , we have characterized the mechanism of
IL-1beta secretion following
RSV infection . -
pubmed
Our study revealed that
NLRP3 /
ASC inflammasome activation is crucial for
IL-1beta production during
RSV infection . -
pubmed
TLR2 /
MyD88 /
NF - kappaB signaling is required for pro - IL-1beta and
NLRP3 gene expression during
RSV infection . -
pubmed
PolyIC GE11 polyplex inhibits
EGFR - overexpressing
tumors . -
pubmed
PolyIC / PPGE11 has a similar strong antitumor effect against
EGFR overexpressing
tumors in vitro and in vivo , as polyIC /
polyethyleneimine -
polyetheleneglycol -
EGF ( polyIC /
PP - EGF ) . -
pubmed
Absence of
EGFR activation , as previously shown by us and easier production of GE11 and GE11 conjugates , confer polyIC / PPGE11 a significant advantage over similar
EGF - based polyplexes as a potential therapy of
EGFR overexpressing
tumors . -
pubmed
Penetrance of
PD in
Glucocerebrosidase Gene Mutation Carriers . -
pubmed
Phosphorylation of
connexin43 on S279/282 may contribute to
laminopathy - associated conduction defects . -
pubmed
We conclude that increased pS279/282
Cx43 in the
Lmna(-/- ) background results in decreased cell communication and may contribute to the
arrhythmic pathology in vivo . -
pubmed
TGF - beta1 enhances tumor - induced angiogenesis via
JNK pathway and macrophage infiltration in an improved
zebrafish embryo / xenograft
glioma model . -
pubmed
TGF - beta1 enhanced
glioma - induced angiogenesis , which was inhibited by
JNK inhibitor
SP600125 but not
p38 MAPK inhibitor
SB202190 ,
ERK inhibitor
PD98059 , or
PI3 K inhibitor
LY294002 , indicating the important role of
TGF - beta1 and
JNK pathways in this process . -
pubmed
Moreover , the
glioma - induced angiogenesis was associated with macrophage infiltration that was further enhanced by
TGF - beta1 . -
pubmed
The syndrome of
heparin - induced
thrombocytopenia (
HIT ) , with an incidence of 0.2 - 0.5 % in
patients exposed to
heparin for more than 4 days , is produced by an immune alteration with the formation of antibodies against the
heparin platelet factor 4 complex . -
pubmed
Dabigatran , a new anticoagulant medicine that is a direct and reversible
thrombin inhibitor , could theoretically be a medicine employed in treating
HIT . -
pubmed
A polymorphism in
IL4 may associate with
sensory neuropathy in African
HIV patients . -
pubmed
DNA samples from all participants were genotyped for
cytokine SNPs identified in studies of
HIV disease and/or
neuropathy . -
pubmed
RESULTS :
IL4 - 590*T associated with an increased prevalence of
HIV - SN including following correction for age , height and
CD4 T - cell count . -
pubmed
DISCUSSION : We identified a novel association between
IL4 - 590*T and
HIV - SN in African
HIV - positive patients which warrants further investigation . -
pubmed
Furthermore , overexpression of
IKBKE correlates with elevated levels of pFOXO3a - S644 in primary lung and
breast tumors . -
pubmed
In one trial of 115
women ,
levothyroxine therapy to treat pregnant euthyroid ( normal thyroid function )
women with
thyroid peroxidase antibodies was not shown to reduce pre -
eclampsia significantly ( risk ratio ( RR ) 0.61 ; 95 % confidence interval ( CI ) 0.11 to 3.48 ) but did significantly reduce
preterm birth by 72 % ( RR 0.28 ; 95 % CI 0.10 to 0.80 ) . -
pubmed
AUTHORS ' CONCLUSIONS : This review found no difference between
levothyroxine therapy and a control for treating pregnant euthyroid
women with
thyroid peroxidase antibodies for the outcome of
pre - eclampsia , however a reduction in
preterm birth and a trend towards reduced miscarriage with
levothyroxine was shown . -
pubmed
Effect of focal mild
hypothermia on expression of
MMP-9 ,
TIMP-1 ,
Tau-1 and
beta - APP in
rats with
cerebral ischaemia /
reperfusion injury . -
pubmed
This study aimed to examine the effects of focal mild
hypothermia on proteins associated with both extracellular (
matrix metalloproteinase-9 (
MMP-9 ) and
tissue inhibitor of MMP-9 (
TIMP-1 ) ) and cellular damage (
Tau-1 and
beta - amyloid precursor protein (
beta - APP ) ) to characterize the protective effects of
hypothermia . -
pubmed
The brains were collected at 6 , 12 , 24 , 48 and 72 hours after
hypothermia to measure infarct volume ratio and to detect cells immunopositive for
MMP-9 ,
TIMP-1 ,
Tau-1 and
beta - APP , while
neurological deficits were examined separately after 2 weeks . -
pubmed
MAIN OUTCOMES AND RESULTS : Focal mild
hypothermia had no effect on infarct volume ratio but expression of
MMP-9 ,
TIMP-1 Tau-1 and
beta - APP was decreased . -
pubmed
CONCLUSIONS : Focal mild
hypothermia has protective effects on
cerebral ischaemia -
reperfusion injury characterized by decreased expression of
MMP-9 ,
TIMP-1 ,
Tau-1 and
beta - APP , along with improvement of neurological function despite no changes in infarct volume . -
pubmed
TDP1 and
PARP1 deficiency are cytotoxic to
rhabdomyosarcoma cells . -
pubmed
Metastatic rhabdomyosarcoma in
children has a 5 - year event - free survival rate of & lt;30 % , and a recent clinical trial with
irinotecan , a
topoisomerase I inhibitor , failed to improve outcome . -
pubmed
Using
human tissue microarrays and gene expression arrays , a marked overexpression of
TDP1 protein and mRNA in
RMS tumors was observed . -
pubmed
Critically , knockdown of
TDP1 or inhibition of
poly ( ADP - ribose ) polymerase-1 (
PARP-1 ) , an enzyme in the same complex as
TDP1 , sensitized
rhabdomyosarcoma cell lines to analogues of
irinotecan . -
pubmed
Interestingly ,
BRCA1 / 2 mutations or altered expression was not detectable in
rhabdomyosarcoma cells ; however ,
TDP1 knockdown and
PARP-1 inhibition alone were cytotoxic to a subset of
rhabdomyosarcoma cells , suggesting that they harbor genetic lesions in DNA repair components that have synthetic lethal interactions with loss of
TDP1 or
PARP1 function . -
pubmed
Furthermore , culturing
embryonal rhabdomyosarcoma cells in serum / nutrient - restricted medium increased cellular
cytotoxicity upon
PARP-1 inhibition and was intrinsically cytotoxic to alveolar , though not
embryonal rhabdomyosarcoma cells . -
pubmed
The results of these studies suggest a compensatory role for
TDP1 in
rhabdomyosarcoma after
topoisomerase - I based therapy and further demonstrate that
TDP1 knockdown ,
PARP-1 inhibition , and dietary restriction have therapeutic validity . -
pubmed
IMPLICATIONS : Selective targeting of
TDP1 and/or
PARP-1 in
rhabdomyosarcoma induces
cytotoxicity and sensitizes to DNA damaging agents . -
pubmed
Elevation of
amyloid beta - peptide (
Abeta ) is critically associated with
Alzheimer disease (
AD ) pathogenesis . -
pubmed
Abeta - induced
synaptic abnormalities , including altered receptor trafficking and synapse loss , have been linked to
cognitive deficits in
AD . -
pubmed
Recent work implicates a lipid critical for neuronal function ,
phosphatidylinositol-4,5 - bisphosphate [
PI ( 4,5 ) P2 ] , in
Abeta - induced
synaptic and behavioral impairments . -
pubmed
Heterozygous deletion of
Synj1 protected neurons from
Abeta - induced
synaptic loss and restored learning and memory in a
mouse model of
AD . -
pubmed
The assay will enable identification of novel
Synj1 inhibitors that have potential utility as chemical probes to dissect the cellular role of
Synj1 as well as potential to prevent or reverse
AD - associated
synaptic abnormalities . -
pubmed
Dp71 - null
mouse is thus an excellent model to approach the study of
retinal pathologies showing blood - retinal barrier permeability . -
pubmed
Sunitinib is a multiple
tyrosine kinase receptor inhibitor that is approved for the treatment of
metastatic renal cell carcinoma (
RCC ) . -
pubmed
CONCLUSIONS : Our results suggest that the
PLS fraction has a protective effect against
intestinal damage through mechanisms that involve the inhibition of inflammatory cell infiltration ,
cytokine releasing and lipid peroxidation . -
pubmed
Inhibition of
COX activity in young
mice by ip injections of NSAIDs causes
dwarfism . -
pubmed
Many potential substrates of
NEDD4 have been identified and
NEDD4 has been shown to play a critical role in the regulation of a number of membrane receptors , endocytic machinery components and the
tumour suppressor
PTEN . -
pubmed
Soluble
VCAM-1 and
E - selectin in
PD patients : the additive value of the free diffusion coefficient in the assessment of local peritoneal production . -
pubmed
Regulation of
pulmonary graft - versus - host disease by
IL-26+
CD26+
CD4 T lymphocytes . -
pubmed
In the current study , we identified a novel effect of
IL-26 on transplant - related obliterative
bronchiolitis . -
pubmed
Histologically , lung of HuCB
mice exhibited obliterative
bronchiolitis with increased
collagen deposition and predominant infiltration with
human IL-26(+)
CD26(+)
CD4 T cells . -
pubmed
Moreover , although
IL-26 is absent from
rodents , we showed that
IL-26 increased
collagen synthesis in fibroblasts and promoted
lung fibrosis in a
murine GVHD model using
IL-26 transgenic mice . -
pubmed
Administration of
Cav - Ig before or after onset of
GVHD impeded the development of clinical and histologic features of
GVHD without interrupting engraftment of donor - derived
human cells , with preservation of the graft - versus -
leukemia effect . -
pubmed
These results therefore provide proof of principle that
cGVHD of the lungs is caused in part by
IL-26(+)
CD26(+)CD4 T cells , and that treatment with
Cav - Ig could be beneficial for
cGVHD prevention and therapy . -
pubmed
To analyze the mechanism of action of
triterpenoids , we investigated intramitochondrial reactive
oxygen species ( ROS ) , mitochondrial membrane potential , mitochondrial mass , mitochondrial dynamics and morphology , and
Lon proteolytic activity in
RKO human colon cancer cells , in
HepG2 hepatocarcinoma cells and in
MCF7 breast carcinoma cells . -
pubmed
In joint analysis of 90,003
IBC and Cardiometabochip SNPs , rs1543654 in the region of
KCNE1 predicted change in BDI scores at Year 1 in
diabetes support and education ( beta = -1.05 , standard error [ SE ] = 0.21 , p = 6.9 x 10(-7 ) ) at the level of chip - wide significance , while also showing a nominal association with baseline BDI ( beta = 0.35 , SE = 0.16 , p = .026 ) . -
pubmed
We identified
KCNE1 as a potential novel locus associated with
depressive symptoms . -
pubmed
Frameshift Sequence Variants in the
Human Lipase - H Gene Causing
Hypotrichosis . -
pubmed
Sequence analysis of the
lipase H (
LIPH ) gene , mapped on chromosome 3q27.3 , led to the identification of a novel frameshift deletion variant ( c.932delC , p. Pro311Leufs*3 ) in one family and previously reported 2 - bp deletion ( c.659_660delTA ) in five other families ,
inherited hypotrichosis , and
woolly hair in an autosomal recessive pattern . -
pubmed
The study further extends the body of evidence that sequence variants in the
LIPH gene result in
hypotrichosis and woolly hair phenotype . -
pubmed
It has been reported that
lysosomal - associated membrane protein 2 (
LAMP2 ) and
heat shock protein ( HSP ) 70 are two calpain substrates that promote
LMP in
cancer cells ; however , it was found that calpains were activated by
glutamate , but only
LAMP2 was subsequently degraded . -
pubmed
Isoform 1 of
TPD52 (
PC-1 ) promotes neuroendocrine transdifferentiation in
prostate cancer cells . -
pubmed
Previous studies confirmed that
PC-1 contributes to malignant progression in
prostate cancer with an important role in castration - resistant stage . -
pubmed
We established for long - term
PC-1 overexpression an inducible expression system derived from the
prostate carcinoma cell line
LNCaP. -
pubmed
In summary , our data provide evidence for an involvement of
PC-1 in NE transdifferentiation , frequently associated with castration resistance , which is a major therapeutic challenge in the treatment of advanced
prostate cancer . -
pubmed
Methylation status of
DJ-1 in leukocyte DNA of
Parkinson ' s disease patients . -
pubmed
BACKGROUND :
DJ-1 has been thought as a candidate biomarker for
Parkinson ' s disease (
PD ) . -
pubmed
Thus , in this study , we try to explore whether blood - based DNA methylation of
DJ-1 could be used as a biomarker to differentiate
PD patients from normal control ( NC ) , and whether DNA methylation could regulate
DJ-1 expression in a
SH - SY5Y cell model . -
pubmed
RESULTS :
CpG sites in these two
CpG islands ( CpG1 and CpG2 ) of
DJ-1 were unmethylated in both
PD and NC group . -
pubmed
CONCLUSIONS : Our results indicated that DNA methylation inhibitor did n't alter
DJ-1 gene expression in
SH - SY5Y cell model , and DNA methylation of
DJ-1 promoter region in PBLs level might not be an efficient biomarker for
PD patients . -
pubmed
Molecular chromosome analysis was performed on fluorescence in situ hybridization in tissue sections from the tissue blocks in all cases for the purpose of this study ; a ratio greater than 2 was considered to represent
murine double - minute 2 (
MDM2 ) amplification consistent with a diagnosis of ALT /
WDL . -
pubmed
RESULTS : Compared with model group , the contents of
Scr and BUN in
rats serum of drug groups were significantly decreased ( P & lt ; 0.05 ) , the
sclerosis of glomerulus was ameliorated , the degree of saccular dilatation and the damage of tubules were alleviated ,
collagen distribution and interstitial
fibrosis was obviously improved , while the expressions of
TGF - beta1 ,
alpha - SMA and
Collagen - I were decreased . -
pubmed
Compared with Rehmanniae Radix Praeparata decoction group , the contents of
Scr and BUN in
rats serum of
Rehmanniae Radix decoction group were lower , the decrease of
collagen distribution and interstitial
fibrosis were more obviously , while the expression of
alpha - SMA was significantly decreased ( P & lt ; 0.05 ) . -
pubmed
CONCLUSION : The effect of
Rehmanniae Radix is more powerful than that of
Rehmanniae Radix Praeparata on attenuating interstitial
fibrosis , which may relative to downregulating the expressions of
TGF - beta1 ,
alpha - SMA and
Collagen - I. -
pubmed
Renal cells under
hyperglycemic or proteinuric conditions exhibit inactivation of cell defense mechanisms such as
AMPK and autophagy , and activation of pathologic pathways such as
mammalian target of rapamycin (
mTOR ) , endoplasmic reticulum ( ER ) stress , epithelial - to - mesenchymal transition ( EMT ) , oxidative stress , and
hypoxia . -
pubmed
As these pathologic pathways are intertwined with
AMPK signaling , the potential benefits of
metformin therapy in
patients with
type 2 diabetes would extend beyond its anti -
hyperglycemic effects . -
pubmed
Moreover , administration of
SN50 ( specific inhibitor of
NF - kappaB ) inhibited the PQ - induced
inflammation - related effects in
SH - SY5Y cells . -
pubmed
The RUN domain
Beclin-1 - interacting
cysteine - rich - containing (
Rubicon ) protein is involved in the maturation step of autophagy and the endocytic pathway as a
Beclin-1 - binding partner , but little is known regarding the role of
Rubicon during
viral infection . -
pubmed
The
Rubicon protein levels were elevated in peripheral blood mononuclear cells , sera and liver tissues from
patients with
hepatitis B virus ( HBV ) infection relative to those in healthy individuals . -
pubmed
Both
Tdp1 and
Tdp2 inhibition could hypothetically potentiate the
cytotoxicities of
topoisomerase inhibitors . -
pubmed
Enzyme inhibitory data and
cytotoxicity data from
human cancer cell cultures establish that modification of the
lactam side chain of the
7 - azaindenoisoquinolines can modulate their inhibitory potencies and selectivities vs
Top1 ,
Tdp1 , and
Tdp2 . -
pubmed
The monitoring of DNA damage by
gamma - H2AX foci formation in
human PBMCs ( lymphocytes ) and
acute lymphoblastic leukemia CCRF - CEM cells documented significantly more DNA damage in the
cancer cells vs normal cells . -
pubmed
NASH- and NASH - related
HCC - specific DNA methylation alterations , which were not evident in viral - N samples and 37 samples of
HCC associated with
HBV or
HCV infection , were observed in tumor - related genes , such as
WHSC1 , and were frequently associated with mRNA expression abnormalities . -
pubmed
We have also established models for the functional screening of profibrotic and antifibrotic drugs based on cFB proliferation , myofibroblast activation , and pericellular
collagen matrix formation , and models of
hypoxia / reoxygenation with appropriate time course and media conditions to achieve consistent cell injury . -
pubmed
Sigma-1 receptors control immune - driven peripheral opioid analgesia during
inflammation in
mice . -
pubmed
Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs , so
sigma-1 receptors constitute a biological brake to opioid drug - induced
analgesia . -
pubmed
Peroxiredoxin-1 of macrophage is critical for
mycobacterial infection and is controlled by early secretory antigenic target protein through the activation of
p38 MAPK . -
pubmed
Early secretory antigenic target protein (
ESAT-6 ) is an important virulent factor which plays a crucial role in
Mycobacterium tuberculosis (
MTB ) pathogenesis . -
pubmed
Long noncoding RNA
Lnc - EGFR promotes cell proliferation and inhibits cell apoptosis via regulating the expression of
EGFR in
human tongue cancer . -
pubmed
Herein , the present study aimed to investigate the role of a newly - discovered
Lnc ,
Lnc -
EGFR in
tongue cancer . -
pubmed
The results showed that the transcript level of
Lnc -
EGFR was upregulated in
patients with
tongue cancer and in cultured
tongue cancer cell lines . -
pubmed
All of these results suggested the oncogenic potential of
Lnc -
EGFR , which was achieved by positive regulation of
EGFR in
human tongue cancer . -
pubmed
The
hAbetaPPswe - bearing offspring from Tg2576 mothers showed an aggravated
AD - like phenotype . -
pubmed
Such progeny , lacking any mutant
amyloid precursor protein , constitutes a novel model to study maternal transmission of
AD and , even more important , to discover early risk markers that predispose to the development of
AD . -
pubmed
In conclusion , these results suggest that Nano -
C3 G can reduce UVB - induced
epidermal damage through the
p53 - mediated apoptosis signaling pathway . -
pubmed
The method is specific for
CKMB , and biomarkers for
AMI ( such as
cardiac troponin I and
myoglobin ) and serum do not interfere . -
pubmed
He was found on admission to be in
cardiogenic shock with an elevated
troponin and intermittent
bifascicular block . -
pubmed
It reduced the
fibrosis - positive areas and the protein levels of
collagen types I and III in the left atrium . -
pubmed
SP promotes cell proliferation in
esophageal squamous cell carcinoma through the
NK1R /
Hes1 axis . -
pubmed
BACKGROUND :
Substance P (
SP ) plays an important role in several types of
cancer promotion and progression by binding to its preferential
neurokinin 1 receptor (
NK1R ) . -
pubmed
However , the clinical significance and downstream mechanism of
NK1R in
esophageal squamous cell carcinoma (
ESCC ) have not been elucidated . -
pubmed
The aim of this study was to investigate the role of
SP /
NK1R in the proliferation of
ESCC and to screen related downstream molecules . -
pubmed
METHODS : In the current investigation , the expression of
NK1R was detected via immunohistochemistry ( IHC ) , western blot ( WB ) analysis and real - time reverse transcription - polymerase chain reaction ( RT - qPCR ) in
ESCC tissues and cell lines . -
pubmed
The proliferation ability of
SP /
NK1R was assessed by cell counting kit-8 ( CCK-8 ) and colony formation assays and
subcutaneous tumour formation in
nude mice with
EC109 cells . -
pubmed
RESULTS :
NK1R was upregulated in
ESCC , and its overexpression correlated with larger
tumour size , deeper
tumour invasion , more perineural invasion and eventually caused poorer overall survival ( OS ) . -
pubmed
Both intrinsic and
SP - activated
NK1R upregulation could promote the proliferation and clonogenic capacity of
ESCC cells . -
pubmed
In
nude mice ,
tumour growth was suppressed by
EC109 cells of
NK1R downregulation . -
pubmed
CONCLUSIONS : The significant role of
NK1R in mediating
ESCC cell proliferation depended on the activation of
SP and might be related to the downstream regulation of
Hes1 . -
pubmed
Physiological effects of cellular
hypoxia are sensed by
prolyl hydroxylase ( PHD ) enzymes which regulate HIFs . -
pubmed
We have shown that stabilization of
HIF levels in adult
mice through
PHD2 enzyme silencing by RNA interference , or inducible recombination of floxed alleles , results in multi - lineage
leukocytosis and features of
autoimmunity . -
pubmed
We have studied the inhibitory effects of
linezolid and
tedizolid and their potential recovery on ( i )
CYTox I expression (
subunit I of cytochrome c - oxidase ; encoded by the mitochondrial genome ) , ( ii )
cytochrome c - oxidase activity , and ( iii ) mitochondrial respiration ( Seahorse bioanalysis ) in two
megakaryocytic cell lines (
UT-7 WT [
human acute megakaryoblastic leukemia cells ] and
UT-7 MPL [ transduced to stably express the
thrombopoietin ( TPO ) receptor ] ) . -
pubmed
CONCLUSIONS :
Tirofiban during CAS might provide peri - procedural myocardial protection and reduce
myocardial injury as determined by serial
troponin measurements . -
pubmed
Fortunately ,
letermovir which targets the
HCMV terminase complex rather than
DNA polymerase with fewer adverse reactions has been approved to treat
CMV infections in
humans . -
pubmed
The gene or RNA targeting approaches including the external guide sequences ( EGSs)-
RNase , the
clustered regularly interspaced short palindromic repeats ( CRISPR )/ CRISPR - associated protein 9 (
Cas9 ) system and
transcription activator - like effector nucleases ( TALENs ) are being investigated to remove acute and/or latent
CMV infections . -
pubmed
Here we used a lambda -
MYC transgenic model of endogenously growing
B - cell lymphoma to analyze the requirements for effective therapy with immune checkpoint inhibitors . -
pubmed
METHODS : Growth of spontaneous
lymphoma was monitored in
mice that received antibodies targeting
programmed cell death protein 1 and
cytotoxic T lymphocyte - associated protein-4 , and the role of different immune cell compartments and
cytokines was studied by in vivo depletion experiments . -
pubmed
Antibody treatment enhanced numbers , proliferation and
IFN - gamma expression of NK cells in developing
tumors . -
pubmed
In the
lymphoma model studied , successful therapy required both , tumor - directed T - cell responses and NK cells , which control , at least partly ,
tumor development through
cytokine - induced
tumor senescence . -
pubmed
Immunohistochemically , paraffin - embedded sections from all eight
CCTL were negative for
cytokeratin (
CK ) ,
epithelial membrane antigen (
EMA ) ,
chromogranin , and
vimentin . -
pubmed
Of more practical importance , the combined absence of
CK ,
EMA , and
vimentin in
formalin - fixed , paraffin - embedded CCTL virtually precludes confusion with
renal cell carcinoma . -
pubmed
Serum levels of transaminases in arrested
animals were significantly elevated ( 258 - 322 % ) while blood
urea nitrogen ,
creatinine , and
creatine kinase were minimally affected , suggesting that the reduced clearance of
MK-801 might be secondary to
hepatic ischemic damage . -
pubmed
use of radiohalogenated
steroid estrogen - receptor (
ER ) ligands as a potential option for diagnosing and treating intra - abdominal , retroperitoneal , and distant sites of advanced
ER - rich malignancies . -
pubmed
Demonstration and characterization of a transient
arthritis in
rats following sensitization of synovial mast cells with antigen - specific
IgE and parenteral challenge with specific antigen . -
pubmed
We have developed a model of
IgE - dependent , mast cell - mediated
arthritis in
rats . -
pubmed
Within 5 minutes of intravenous injection of antigen , an acute , transient
arthritis occurred in the test joints only , with swelling and extravasation of intravascular blue dye and 125I - labeled
albumin , decreased numbers of stainable mast cells , and decreased
histamine content of the joint synovium . -
pubmed
These data show that
IgE - dependent synovial mast cell degranulation causes a transient , nondestructive
arthritis , reminiscent of
lupus arthritis and intermittent
hydrarthrosis . -
pubmed
Clinical evaluation of
steroid receptors in
ovarian neoplasms . -
pubmed
Estrogen and progesterone receptors were estimated in a total of 25
ovarian neoplasms . -
pubmed
None of the benign
tumors showed
steroid receptors . -
pubmed
In the preliminary experiments , we applied this method for determination of
CCK content in the brain regions of adult
rats treated with
6 - hydroxy - dopamine or in newborn
rats subjected to
anoxia , and showed that this system is applicable to detection of changes of endogenous
CCK content . -
pubmed
Neuroblastoma cells contain a trophic factor sharing biological and molecular properties with
ciliary neurotrophic factor . -
pubmed
High - speed supernatants of extracts from two
neuroblastoma ( NB ) cell lines -- the
mouse C 1300 N2a and the
human IMR 32 - -mimic the effects of
CNTF on identical target neurons . -
pubmed
These data suggest that the inhibitory action and potency of
nucleoside dialdehydes on
neuroblastoma growth are independent of their capacity to undergo a
kinase - mediated phosphorylation at the 5 ' position . -
pubmed
On account of many literature reports about the definite correlation between high
animal protein intake and
cardiovascular diseases , we have studied the effect of a hyperproteic purified diet ( casein 40 % ,
lactalbumin 20 % ) on fetal and post - natal ( not further than 40th day ) stage of the
rat , when cell subdivision process is faster and therefore damage by nutritional imbalance is certainly more serious . -
pubmed
The irregular nephrographic phase was associated with a transient accumulation of platelets and
fibrinogen in the kidney and with microscopically demonstrable transient
thrombi in afferent arterioles and glomerular capillary tufts . -
pubmed
[ Detection of
anti - M antibodies by passive hemagglutination test in
streptococcal infections in children ] . -
pubmed
[ Fetal
hemoglobin in
blood diseases ] . -
pubmed
[ Quantitative histophotometric study of
liver dehydrogenase activity during temporary
ischemia of the extremities ] . -
pubmed
The increase in the activities of
dehydrogenases under study in the course of a 3 - hour
ischemia , and the decrease of these parameters in 6- and 12 - hour
ischemia was discovered , that was determined as a compensatory response followed by the period of compensation exhaustion and the development of the period of complete exhaustion . -
pubmed
[ An
ACTH - secreting
carcinoid tumor of the thymus . -
pubmed
Aflatoxin M1 (
AFM1 ) , a metabolic hydroxylation product of
aflatoxin B1 (
AFB1 ) , and the parent compound were comparatively assayed for DNA - damaging potency and
genotoxicity in vivo in
Drosophila melanogaster using , respectively , the
mei-9a mei-41D5 DNA repair test and the
mwh /
flr3 wing spot test . -
pubmed
Expression of
mdr1 gene in
human breast primary tumors and metastases . -
pubmed
Expression of
mdr1 gene has been evaluated in 34
tumor samples obtained from
breast cancer patients who were classified according to their treatment , and clinical follow - up . -
pubmed
mdr1 - RNA was never detected in 29 primary
breast tumors including 5 samples from
patients previously treated by 6 courses of
5 - fluorouracil ,
epirubicin ,
cyclophosphamide (
FEC ) . -
pubmed
In conclusion , evaluation of
mdr1 - RNA seemed to be of little interest in primary
breast tumors . -
pubmed
However , the concomitant presence of an
mdr1 - RNA and a metastatic phenotype could give a new insight into the relationship between invasive and resistance properties of
cancer cells . -
pubmed
Taken together , these data suggest that the endoproteolytic cleavage of
gp160 occurs in the ER or cis - Golgi network , and
ER retention strategies can potentially be used in preventing the spread of
HIV-1 infection in permissive cells . -
pubmed
With the discovery of the
obesity gene and its product ,
leptin , we reexamined this hypothesis from a new perspective . -
pubmed
As delayed menarche and leanness are considered risk factors for
osteoporosis , we also evaluated the relation between
leptin and bone mass . -
pubmed
Leptin may also mediate the effect of
obesity on bone mass by influencing the periosteal envelope . -
pubmed
Salt restriction : effects on lipids and
insulin production in
hypertensive patients . -
pubmed
The object of the study was to evaluate blood pressure ,
insulin and
glucose metabolism , and serum lipids in
hypertensive patients , during 8 weeks on a moderately salt - restricted diet . -
pubmed
The concept of a safe , immunocontraceptive vaccine using the
zona pellucida glycoprotein 3 (
ZP3 ) as an immunogen has been marred by the appearance of
ovarian dysfunction in several
species . -
pubmed
However , careful selection of epitopes on
mouse ZP3 have demonstrated that it is possible to segregate contraceptive bone marrow - derived ( B)-cell epitopes from the cytotoxic thymus - derived ( T)-cell epitopes thought to be responsible for inducing
ovarian disease . -
pubmed
Loss of
cyclin D1 in
necrotic and apoptotic models of cortical
neuronal degeneration . -
pubmed
Role of
S-100beta as potential autoantigen in an
autoimmune disease of the inner ear . -
pubmed
In Lewis
rats , adoptive transfer of T cells specific for the
calcium - binding protein S-100beta mediates experimental
autoimmune encephalomyelitis , but surprisingly also induced a marked
labyrinthitis associated with
impairment of hearing . -
pubmed
This suggests that transfer of
S-100beta - specific T cells into susceptible
animals could be a novel model to study autoimmunity of
inner ear diseases . -
pubmed
Bovine beta - casein antibodies in breast- and bottle - fed infants : their relevance in
Type 1 diabetes . -
pubmed
BACKGROUND :
Bovine beta - casein is a
cow 's milk protein that targets both humoral and cellular immune responses in
patients with
Type 1 diabetes and , to a lesser degree , also in normal subjects . -
pubmed
In addition ,
beta - casein antibodies were measured in 37 prepubertal
children with
Type 1 diabetes and in 31 healthy
children who were exposed to
cow 's milk or dairy products to see whether differences in antibody titers exist in this young age group . -
pubmed
Antibody levels to
bovine beta - casein were also significantly higher in
children with
Type 1 diabetes compared to age - matched controls ( p=0.03 ) . -
pubmed
By western blot analysis we confirmed specific binding to
bovine beta - casein in bottle - fed infants , in
children with
Type 1 diabetes and in controls exposed to
cow 's milk , but not in infants who were exclusively breast - fed . -
pubmed
The class of drugs known as the
5 - HT3 receptor antagonists have become widely used for chemotherapy - induced
nausea and
vomiting , and are considered a standard part of care for moderately- and highly - emetogenic chemotherapy in combination with
corticosteroids . -
pubmed
More recently , oral
5 - HT3 receptor antagonists have demonstrated efficacy in the prevention of
nausea and
vomiting due to highly - emetogenic chemotherapy as well . -
pubmed
Despite
hyperinsulinemia , the activity level of this enzyme was significantly higher in db / db
mice , and the mRNA level of hepatic
11beta - HSD1 was also significantly higher in db / db
mice . -
pubmed
The increased hepatic
corticosterone concentration due to the elevation of
11beta - HSD1 and high plasma
corticosterone concentration may antagonize the action of
insulin and cause
insulin resistance . -
pubmed
AIMS : The primary objective of this study was to determine the efficacy and safety of
lamivudine (
LAM ) therapy in
patients with chronic
HBV infection and contraindications to
IFN therapy , nonresponders to
IFN and
patients with advanced
liver fibrosis . -
pubmed
CONCLUSIONS : The results indicate that monotherapy with
lamivudine ( 150 mg daily ) for 48 weeks induces sustained inhibition of viral replication and normalisation of
transminases in majority of
patients with chronic
HBV infection who did not respond to
IFN , had contraindications to
IFN therapy , and in those who had advanced
liver fibrosis . -
pubmed
Epsilon - amino caproic acid additive decreases
fibrin bandage performance in a
swine arterial bleeding model . -
pubmed
epsilon - Amino caproic acid (
EACA ) , a
lysine analog that inhibits the activity of
plasmin , was added to Nycomed ( TC - S )
fibrin bandages , and the bandages were tested for hemostatic efficacy in a
swine femoral artery bleeding model . -
pubmed
Distribution of codon 129 genotype in
human growth hormone - treated
CJD patients in France and the UK . -
pubmed
Since homozygosity MM at codon 129 of the
prion protein gene is a recognised risk factor in all forms of
Creutzfeldt - Jakob disease (
CJD ) , we studied the distribution of codon 129 polymorphism in patients in France and in the UK with
CJD transmitted iatrogenically by
human growth hormone . -
pubmed
There is no evident explanation for this different distribution , which might be due to
infection with different strains of prion in
human growth hormone . -
pubmed
[ Effect of long - acting
ACTH on behavior of
blood eosinophilia ] . -
pubmed
TARTRATE - INHIBITED
ACID PHOSPHATASE IN
BENIGN PROSTATIC HYPERTROPHY AND IN
PROSTATIC CANCER . -
pubmed
Partial
A ( 1 ) adenosine receptor agonists from a molecular perspective and their potential use as chronic ventricular rate control agents during
atrial fibrillation (
AF ) . -
pubmed
The challenges associated with designing a partial
A ( 1 )- adenosine receptor agonist for providing chronic ventricular rate control during
atrial fibrillation are many . -
pubmed
CD4 - T - lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to
pneumococcal infection . -
pubmed
Tumour - expressed
CD43 (
sialophorin ) mediates tumourmesothelial cell adhesion . -
pubmed
Mesothelial cell intercellular adhesion molecule-1 (
ICAM-1 ) has recently been shown to play a role in
tumour cell adherence to the peritoneum . -
pubmed
However , solid
tumours poorly express its most ubiquitous ligand ,
beta2 integrin . -
pubmed
beta2 Integrin subunit and
CD43 expression was assessed on a number of
tumour cell lines . -
pubmed
beta2 Integrin expression was not inducible on these
tumour cell lines , but Western blotting demonstrated
CD43 expression in all the
cancer cell lines examined and cell surface expression was confirmed by flow cytometry . -
pubmed
The anti -
CD43 antibody significantly reduced adhesion of
PSN-1 and
SW1222 cells to HPMC , however
beta2 integrin inhibition did not reduce
tumour cell adhesion . -
pubmed
CD43 is expressed by a variety of
carcinoma cell lines , and plays a role in
tumour cell - peritoneal adhesion probably via interactions with its putative ligand
ICAM-1 . -
pubmed
Regulation of multidrug resistance by
ribosomal protein l6 in
gastric cancer cells . -
pubmed
The aim of this study was to explore the roles of
RPL6 in multidrug resistance ( MDR ) in
gastric cancer cells . -
pubmed
Together , this work demonstrates that
RPL6 could regulate MDR in
gastric cancer cells by suppressing drug - induced apoptosis . -
pubmed
A series of
combretastatins substituted with
epoxides ,
amides and small
alkyl groups has been synthesised and evaluated for
cytotoxicity and their ability to inhibit the assembly of
tubulin . -
pubmed
Paraoxonases and
cardiovascular diseases : pharmacological and nutritional influences . -
pubmed
PURPOSE OF REVIEW : To summarize the new articles published in the last year on
paraoxonases , including their expression in
cardiovascular diseases , and regulation by pharmacological and nutritional means . -
pubmed
PON1 activity and mass are both reduced in
cardiovascular diseases and the hypocholesterolemic drugs , statins , increase serum
PON1 activity ( by reducing oxidative stress , or by upregulating hepatic
PON1 expression ) . -
pubmed
Some drugs and nutrients including dietary antioxidants and
polyphenols considerably increase the activities of
paraoxonases which , in turn , can reduce oxidative stress and
atherosclerosis development . -
pubmed
Treating
OSA patients with continuous positive airway pressure can prevent or improve
hypertension , reduce abnormal elevations of inflammatory
cytokines and adhesion molecules , reduce excessive sympathetic tone , avoid increased vascular oxidative stress , reverse
coagulation abnormalities , and reduce
leptin levels . -
pubmed
CD10 expression was evaluated in 45
patients with diagnosis of
Diffuse large B - cell lymphomas . -
pubmed
CD10 antigen expression may have importance as one of the prognostic factors in
patients with diagnosis of
diffuse large B - cell lymphomas . -
pubmed
Sotos syndrome is a well - known anomaly syndrome characterized by overgrowth ,
characteristic facial gestalt , and
developmental delay , and haploinsufficiency of the
NSD1 gene has been revealed as one of the major genetic causes . -
pubmed
We examined three cases with typical
Sotos syndrome , which also were confirmed by genetic analysis with a specific probe for the
NSD1 gene . -
pubmed
Cytokeratin profiles of
male breast cancers . -
pubmed
The identification of distinct
cytokeratin (
CK ) profiles ( basal as opposed to luminal cells ) helps to identify subsets of
tumours with different clinical behaviour . -
pubmed
The aim of this study was to investigate
CK expression in
male breast cancer . -
pubmed
All cases expressing either
CK5 / 6 or
CK14 were invasive
carcinomas of high nuclear and histological grade and were also larger compared with the
tumours not expressing
CK5 / 6 and
CK14 . -
pubmed
All
tumours except three ( also negative for
CK5 / 6 ) expressed
CK18 and
CK19 . -
pubmed
The four
basal - like tumours were negative for
Her-2 expression . -
pubmed
The expression of
CK5 / 6 and
CK14 identifies a subset of pathologically aggressive
male breast cancers . -
pubmed
MDM2 and
HMGA2 amplification were found in a subset of stromal cells in the hamartomatous component and in most cells of the well - differentiated
liposarcoma . -
pubmed
No rearrangement
HMGA2 was found in the
pulmonary hamartoma component . -
pubmed
PATIENTS AND METHODS : Using stem loop - primed reverse transcription and TaqMan quantitative real - time polymerase chain reaction , the expression of 156 mature miRNAs was evaluated using pooled granulocytes from
PMF patients , either wild - type or
JAK2(617V>F ) mutant with & gt;51 % allele burden , and control subjects . -
pubmed
The gene for
ARPKD (
PKHD1 ) is located on chromosome 6p12 and encodes a protein called
fibrocystin / polyductin ( FPC ) , 1 of many proteins that are normally present at the primary cilia of the renal tubules and intrahepatic bile ducts . -
pubmed
FPC probably works in conjunction with cellular proteins involved in
autosomal dominant polycystic kidney disease that is ,
polycystin-1 and
polycystin-2 , which are also located in the primary cilia . -
pubmed
Genetic abnormalities in
PKHD1 may result in
structural and functional abnormalities of FPC , leading to cystic phenotype . -
pubmed
Adult T cell leukemia is a mature CD4 + T cell malignancy which predominantly expresses
CCR4 and is etiologically associated with
human T cell leukemia virus type 1 ( HTLV-1 ) . -
pubmed
The genes of penile development (
HOX ,
FGF ,
Shh ) and testicular determination (
WT1 ,
SRY ) and those regulating the synthesis [
luteinizing hormone ( LH ) receptor ] and action of
androgen (
5alpha reductase ,
androgen receptor ) can cause
hypospadias if altered . -
pubmed
Impairment of
clathrin - mediated endocytosis via cytoskeletal change by epithelial to fibroblastoid conversion in
HepG2 cells : a possible mechanism of
des - gamma - carboxy prothrombin production in
hepatocellular carcinoma . -
pubmed
Des - gamma - carboxy prothrombin (
DCP ) has been well established as a
hepatocellular carcinoma (
HCC )
tumor marker . -
pubmed
Because , as previously reported , the down - regulation of
E - cadherin or high serum
DCP in
HCC patients is associated with a high risk of vascular invasion , intra - hepatic metastasis and
tumor recurrence , we examined if
HCC cells might produce
DCP by epithelial to fibroblastoid conversion ( EFC ) in vitro . -
pubmed
A proteomic approach identified
growth hormone - dependent nutrition markers in
children with
idiopathic short stature . -
pubmed
This study used a pharmaco - proteomic approach in order to identify novel biomarkers that discriminate between short non - GH - deficient (
GHD )
children who show a good or poor growth response to
GH treatment . -
pubmed
CONCLUSION : Our results suggest that
transthyretin and
apolipoprotein A - II may have a role in
GH sensitivity and could be used as markers to predict which short prepubertal
children with
ISS will show a good or poor response to
GH treatment . -
pubmed
METHODS : Key studies supporting the importance of surrogate markers as diagnostic and prognostic predictors of cardiovascular and renal clinical outcomes in
hypertension , as well as what is known about the effects of
renin -
angiotensin -
aldosterone system - blocking agents on these biomarkers were reviewed . -
pubmed
RESULTS : Clinical data supporting the use of surrogate markers for
heart failure , such as
brain natriuretic peptide (
BNP ) and
N - terminal prohormone BNP ; markers for renal function , such as urinary
albumin to
creatinine ratio ( UACR ) , urinary
albumin excretion rates ( UAER ) , and
creatinine , reflecting glomerular filtration ; and markers of cardiac remodeling , such as
left ventricular hypertrophy and calculations of left ventricular mass index ( LVMI ) , were reviewed for their utility in improving prognosis and treatment efficacy . -
pubmed
Finally ,
hypertension treatment with
angiotensin - converting enzyme inhibitors ,
angiotensin receptor blockers , and potentially direct
renin inhibitors can significantly improve outcomes predicted by surrogate markers . -
pubmed
CONCLUSIONS :
BNP , UACR , UAER , and LVMI , among others , have been increasingly established as valid surrogate markers with significant value for
hypertension prognosis and therapy . -
pubmed
Ki-67 protein expression in smokeless
tobacco ( maras powder)-induced
oral mucosal lesions . -
pubmed
CONCLUSIONS : Our study has shown that
MP may induce epithelial cell proliferation , and that there was a significant positive association of
Ki-67 expression and grade of dysplasia in MP users . -
pubmed
Resistance to
transforming growth factor beta - mediated
tumor suppression in
melanoma : are multiple mechanisms in place ? -
pubmed
Resistance to
transforming growth factor ( TGF ) beta - mediated
tumor suppression in
melanoma appears to be a crucial step in
tumor aggressiveness since it is usually coupled with the ability of
TGFbeta to drive the oncogenic process via autocrine and paracrine effects . -
pubmed
In
melanoma , some models of resistance to
TGFbeta have been suggested and will be described . -
pubmed
PURPOSE :
68Ga - DOTA - DPhe1,Tyr3 - octreotate (
68Ga - DOTATATE ) is a
somatostatin analogue that shows high affinity for
somatostatin receptor subtype 2 (
sst2 ) and has been used for imaging
neuroendocrine tumours . -
pubmed
Phospholipase C beta 1 expression in the dorsolateral prefrontal cortex from
patients with
schizophrenia at different stages of illness . -
pubmed
OBJECTIVE : Our recent microarray study detected decreases in the expression of
phospholipase C beta 1 mRNA in the dorsolateral prefrontal cortex from
subjects with
schizophrenia at different stages of illness . -
pubmed
METHOD : We measured levels of mRNA and protein for
phospholipase C beta 1 variant a and b using real - time PCR and western blot analysis , respectively , in the dorsolateral prefrontal cortex from
subjects with
schizophrenia , who had a short ( & lt ; 7 years ) or long ( & gt ; 22 years ) duration of illness . -
pubmed
RESULTS : Compared to age / sex matched controls , levels of
phospholipase C beta 1 variant a and b mRNAs were decreased ( -33 % and -50 % , respectively ) in short duration
schizophrenia . -
pubmed
There was no significant difference in the protein levels of either
phospholipase C beta 1 variant in
schizophrenia , irrespective of duration of illness ( variant a ; P = 0.84 , variant b ; P = 0.73 ) . -
pubmed
CONCLUSION : Our data confirm that
phospholipase C beta 1 transcript levels are decreased in the dorsolateral prefrontal cortex from subjects with
schizophrenia . -
pubmed
Intracerebral administration of
brain - derived neurotrophic factor (
BDNF ) reduces severity of
cataleptic freezing in
mice with genetic predisposition to
catalepsy . -
pubmed
Single administration of
brain - derived neurotrophic factor (
BDNF ) into the lateral ventricle of ASC
mice ( Antidepressant Sensitive
Catalepsy ) , a model of
depression - like state , significantly decreased predisposition to
cataleptic freezing in these
animals . -
pubmed
Medulloblastoma : clinicopathological correlates of
SHH , WNT , and non -
SHH / WNT molecular subgroups . -
pubmed
This manuscript reports the validation of a novel diagnostic immunohistochemical method to distinguish
SHH , WNT , and non -
SHH / WNT
tumors and details their associations with clinical , pathological and cytogenetic variables . -
pubmed
A cohort ( n = 235 ) of
medulloblastomas from
patients aged 0.4 - 52 years was studied for expression of four immunohistochemical markers :
GAB1 ,
beta - catenin ,
filamin A , and
YAP1 . -
pubmed
Immunoreactivity ( IR ) for
GAB1 characterizes only
SHH tumors and nuclear IR for
beta - catenin only WNT
tumors . -
pubmed
IRs for
filamin A and
YAP1 identify
SHH and WNT
tumors . -
pubmed
SHH ,
WNT , and non -
SHH / WNT
tumors contributed 31 , 14 , and 55 % to the series . -
pubmed
All
desmoplastic / nodular ( D / N )
medulloblastomas were
SHH tumors , while most WNT
tumors ( 94 % ) had a classic phenotype . -
pubmed
Monosomy 6 was strongly associated with WNT
tumors , while
PTCH1 loss occurred almost exclusively among
SHH tumors . -
pubmed
MYC or
MYCN amplification and chromosome 17 imbalance occurred predominantly among non -
SHH / WNT
tumors . -
pubmed
Among patients aged 3 - 16 years and entered onto the SIOP PNET3 trial , outcome was significantly better for children with WNT
tumors , when compared to SHH or non -
SHH / WNT
tumors , which showed similar survival curves . -
pubmed
However , high - risk factors ( M+
disease ,
LC / A pathology ,
MYC amplification ) significantly influenced survival in both SHH and non -
SHH / WNT groups . -
pubmed
We describe a robust method for detecting
SHH , WNT , and non -
SHH / WNT molecular subgroups in
formalin - fixed
medulloblastoma samples . -
pubmed
Common variation in
GPC5 is associated with acquired
nephrotic syndrome . -
pubmed
Here we identify an association between variants in
GPC5 , encoding
glypican-5 , and acquired
nephrotic syndrome through a genome - wide association study and replication analysis ( P value under a recessive model ( P(rec ) ) = 6.0 x 10(-11 ) , odds ratio = 2.54 ) . -
pubmed
This study identifies
GPC5 as a new susceptibility gene for
nephrotic syndrome and implicates
GPC5 as a promising therapeutic target for reducing podocyte vulnerability in
glomerular disease . -
pubmed
Urine
IL-8 concentrations are known to be elevated in
urinary tract infection (
UTI ) , as well as in
vesicoureteral reflux (
VUR ) even in the absence of
infection . -
pubmed
In this study we further investigated urine
IL-8 in infants with
congenital anomalies of the kidneys and urinary tract and with antenatally diagnosed isolated
pelvic dilatation . -
pubmed
Urine
IL-8 was measured in 159
infants aged 1 month to 1 year with acute
UTI ( group A , n = 26 ) , resolved
UTI ( group B , n = 16 ) ,
VUR without recent
UTI ( group C , n = 44 ) , non - VUR congenital
urinary anomalies without recent
UTI ( group D , n = 30 ) , isolated antenatal
pelvic dilatation ( group E , n = 14 ) and in infants without known urinary tract condition ( control group F , n = 29 ) . -
pubmed
Compared with the control group , urine
IL-8 was elevated in infants with acute
UTI ,
VUR without acute
UTI and
congenital anomalies without acute
UTI ( p & lt ; 0.0001 ; p & lt ; 0.005 ; and p = 0.027 respectively ) , but not in infants with resolved
UTI or with antenatal
pelvic dilatation . -
pubmed
Urine
IL-8 levels are elevated in a variety of infectious and non - infectious urinary tract conditions , and hence may serve as a sensitive but not specific screening biomarker of
urinary tract diseases . -
pubmed
Beta - cell specific deletion of
Dicer1 leads to defective
insulin secretion and
diabetes mellitus . -
pubmed
In contrast to their normoglycaemic control littermates (
RIP - Cre(+/- )
Dicer1(Delta / wt ) ) ,
RIP - Cre(+/-)
Dicer1(flox / flox )
mice (
RIP - Cre
Dicer1(Delta / Delta ) ) developed progressive
hyperglycaemia and
full - blown diabetes mellitus in adulthood that recapitulated the natural history of the spontaneous disease in
mice . -
pubmed
Reduced
insulin gene expression and concomitant reduced
insulin secretion preceded the
hyperglycaemic state and
diabetes development . -
pubmed
In conclusion , we have demonstrated that a beta - cell specific disruption of the miRNAs network , although allowing for apparently normal beta - cell development , leads to progressive impairment of
insulin secretion ,
glucose homeostasis and
diabetes development . -
pubmed
The prescription drug
memantine , identified as an
NMDA receptor antagonist , prevented the post - anesthesia upper airways dysfunction and alleviated
tauopathy in the nucleus ambiguus and Kolliker - Fuse . -
pubmed
Thus , our experimental findings in a validated
mouse model for
tauopathy demonstrate the link between
isoflurane anesthesia , earlier onset of
tauopathy and earlier onset of functional deficits , highlight the implication of
NMDA - receptors in the mechanisms mediating the adverse effects of
isoflurane , and potentially identify safer protocols for anesthesia in
patients with
tauopathy . -
pubmed
EGFR and
KRAS mutational analysis and their correlation to survival in
pancreatic and periampullary cancer . -
pubmed
OBJECTIVES :
Pancreatic and periampullary cancers have a high incidence of activating
KRAS mutations . -
pubmed
The aim of this study was to determine the incidence of
KRAS and
EGFR mutations in
pancreatic and periampullary cancers and their relationship with survival . -
pubmed
CONCLUSIONS :
EGFR somatic mutations are rare in
pancreatobiliary malignancies . -
pubmed
Pharmacological mechanisms of
5 - HT3 and
tachykinin NK1 receptor antagonism to prevent chemotherapy - induced
nausea and
vomiting . -
pubmed
The introduction of
5 - HT ( 3 ) receptor antagonists in the 90s was a major advance in the prevention of acute
emesis . -
pubmed
In contrast , delayed
emesis has been largely associated with the activation of
neurokinin 1 ( NK ( 1 ) ) receptors by
substance P. -
pubmed
However , in 2003 , a new
5 - HT ( 3 ) receptor antagonist was introduced into the market ; unlike first generation
5 - HT ( 3 ) receptor antagonists ,
palonosetron was found to be effective in preventing both acute and delayed chemotherapy induced
nausea and
vomiting . -
pubmed
The role of
ADAM-8 in
cancer and
inflammatory diseases such as
allergy ,
arthritis and
asthma makes it an attractive target for drug development . -
pubmed
PURPOSE : To investigate whether suppression of plasma
estradiol and
estrone sulfate levels by the
aromatase inhibitors ( AIs )
anastrozole and
letrozole is related to body mass index ( BMI ) in postmenopausal
women with early
estrogen receptor (
ER ) -positive
breast cancer . -
pubmed
Neurotransmitter
CART as a New Therapeutic Candidate for
Parkinson ' s Disease . -
pubmed
In this article , we summarize recent progress in studies investigating the relationship between
CART ,
dopamine , and the pathophysiology of
PD , with a focus on mitochondria - related topics . -
pubmed
METHODS : This study analyzed
thrombi retrieved by mechanical thrombectomy from cerebral arteries in 48 consecutive
patients with
acute ischemic stroke for the presence of endothelial cells using
CD34 antibodies . -
pubmed
RESULTS : Of 48
thrombi analyzed ,
CD34 - positive cells were absent in 20 , present as isolated cells in 21 , and found in clusters in 7
thrombi . -
pubmed
Altered
ketones suggest that systemic metabolism may play a critical role in preventing
neurological injury , while altered
succinate provides a possible explanation for
hypoxia - inducible factor 1 - alpha (
HIF-1alpha ) stabilization in
HI injury . -
pubmed
Unilateral intrastriatal administration of QA ( 300 nmol/4 microl ) significantly reduced body weight ,
impaired behavior ( locomotor activity , beam balance and memory performance ) , caused oxidative damage ( increased lipid peroxidation ,
nitrite concentration , depleted
super oxide dismutase and
reduced glutathione ) , demonstrated
mitochondrial dysfunction ( decreased
Complex - I , II , III , and IV activities ) , increased striatal lesion volume and altered the levels of
TNF - alpha ,
caspase-3 as well as
BDNF expression , as compared to sham group . -
pubmed
IP deficiency inhibited starvation - induced hepatic gluconeogenesis , thus inhibiting the progression of
diabetes , whereas hepatic overexpression of IP increased gluconeogenesis . -
pubmed
We therefore conclude that suppression of
IP modulation of hepatic gluconeogenesis through the
PKA /
CREB and
PI3K - gamma / PKC - zeta /
TRB3 /
AKT pathways contributes to the effects of NSAIDs in
diabetes . -
pubmed
Decreased concentration of
IL-35 in plasma of
patients with
asthma and
COPD . -
pubmed
BACKGROUND :
IL-35 has been found to be involved in many
inflammatory diseases in
humans but its role in
asthma and
chronic obstructive pulmonary disease (
COPD ) is not clear . -
pubmed
The plasma level of
IL-35 in
patients with
asthma and
COPD needs to be measured . -
pubmed
OBJECTIVE : The aim of this study was to examine the plasma concentrations of
IL-35 in newly diagnosed
asthmatic and
COPD patients and control subjects and investigate correlations of lung function , age , sex , smoking history with the levels of
IL-35 in plasma in these diseases . -
pubmed
RESULT : The median and the range of values for
IL-35 were 118.55 pg / ml ( range 74.43~1767.22 pg / ml ) in
patients with
asthma , 136.09 pg / ml ( range 62.54~697.49 pg / ml ) in
patients with
COPD and 275.86 pg / ml ( range 26.11~1766.20 pg / ml ) in control subjects . -
pubmed
The levels of
IL-35 in plasma showed a positive correlation with FEV1 % and FVC% in
asthmatic patients whose plasma
IL-35 values were over 150 pg / ml . -
pubmed
A positive correlation was also found between plasma
IL-35 and FVC% in
COPD patients whose plasma
IL-35 values were over 150 pg / ml . -
pubmed
CONCLUSIONS : These findings suggest that
IL-35 may very probably be involved in the Th2 and Th17 mediated inflammation process of
asthma and
COPD . -
pubmed
Cutaneous ulceration in
dermatomyositis : association with
anti - melanoma differentiation - associated gene 5 antibodies and
interstitial lung disease . -
pubmed
In multivariate analysis
ulcers were significantly associated with
anti - melanoma differentiation gene 5 ( anti -
MDA5 ) antibodies ( odds ratio 10.14 , 95 % confidence interval 1.95 - 52.78 ; P = 0.0059 ) and this was greatest for
ulcers located at the digital pulp . -
pubmed
In
patients with
cutaneous ulcers ,
ILD risk was specifically increased only in patients with anti -
MDA5 - positive antibodies . -
pubmed
CONCLUSION : We confirmed the strong association between anti -
MDA5 antibodies and
cutaneous ulcers , with the novel finding that the association of
cutaneous ulcers with
ILD depends upon the presence of anti -
MDA5 antibodies . -
pubmed
Preferential accumulation of targeted PEGylated liposome - ICG was studied after intravenous administration in comparison to non - targeted PEGylated liposome - ICG using both fast growing (
4T1 ) and slow growing (
HT-29 )
MUC-1 positive
tumour models . -
pubmed
Rapid accumulation was observed for targeted liposomes at early time points mainly in the periphery of the
tumour volume suggesting binding to available
MUC-1 receptors . -
pubmed
Reduced size and macrophage content of advanced
atherosclerotic lesions in
mice with bone marrow specific deficiency of
alpha 7 nicotinic acetylcholine receptor . -
pubmed
All these observations are suggestive of a potential role of macrophage
alpha7nAChR in
atherosclerosis . -
pubmed
However , recent studies that focused on the impact of
hematopoietic deficiency of
alpha7nAChR on early
atherosclerotic lesions of
low density lipoprotein receptor knockout ( LDLRKO )
mice , yielded controversial results . -
pubmed
Here we used
LDLR knockout
mice transplanted with bone marrow from wild - type or
alpha7nAChR knockout
animals to revisit the effect of
hematopoietic deficiency of
alpha7nAChR on early lesions and to examine , for the first time , its impact on advanced plaques . -
pubmed
These studies are the first in examining the impact of
hematopoietic deficiency of
alpha7nAChR on the characteristics of advanced
atherosclerotic lesions in a
mouse model of the disease and provide novel evidence underscoring a potential pro - atherogenic role of macrophage
alpha7nAChR. -
pubmed
The Prevalence of
Anemia of
Chronic Disease in Patients With
Spinal Cord Injuries and
Pressure Ulcers and the Impact of
Erythropoietin Supplementation on Wound Healing : A Descriptive Pilot Study . -
pubmed
Anemia of chronic disease (
ACD ) is thought to impair the responsiveness of erythroid progenitor cells , but research has shown treatment with recombinant
human erythropoietin (
rhuEPO ) can improve
patient hemoglobin levels and , subsequently , overall
patient health status and quality of life . -
pubmed
A prospective pilot study was designed to estimate the prevalence of
ACD in
outpatients with
spinal cord injury (
SCI ) and
chronic pressure ulcers (
PUs ) and examine the impact of
rhuEPO on PU healing in this population . -
pubmed
The charts of 49
SCI patients with
PUs were reviewed ; of those , 17 had
anemia (
hemoglobin & lt;110 g / L ) . -
pubmed
This research indicates
rhuEPO treatment may improve some outcomes for ACD -
SCI PU
patients , but larger randomized controlled trials are required . -
pubmed
We previously reported that
IL-6R ,
STAT3 and miR-34a form a positive feedback - loop , which promotes epithelial to mesenchymal transition ( EMT ) , invasion , and metastasis of
colorectal cancer (
CRC ) [ 1 ] . -
pubmed
Accordingly , the concentration of s -
IL6R protein was decreased in conditioned media of
CRC cell lines ectopically expressing miR-34a . -
pubmed
Rho - GTPase and
Atherosclerosis : Pleiotropic Effects of Statins . -
pubmed
Antagonistic Relationship between
Human Cytomegalovirus pUL27 and
pUL97 Activities during
Infection . -
pubmed
During
infection , inhibition of the
kinase resulted in elevated levels of
p21 ( Cip1 ) in wild - type virus but not a
pUL27 - deficient virus . -
pubmed
In addition , these studies further support the notion that
CDK inhibitors or
p21 ( Cip1 ) activators might be useful in combination with MBV to effectively inhibit
HCMV infections . -
pubmed
Significance of
FGF9 gene in resistance to anti -
EGFR therapies targeting
colorectal cancer : A subset of
colorectal cancer patients with
FGF9 upregulation may be resistant to anti -
EGFR therapies . -
pubmed
Although
fibroblast growth factor (
FGF ) signals are strongly associated with malignancy , limited information is available regarding the role of the
FGF9 signal in
colorectal cancer (
CRC ) . -
pubmed
In this study , we investigated the frequency of
FGF9 amplification in
CRC clinical specimens and the association between the
FGF9 gene and resistance to anti -
EGFR therapies . -
pubmed
In both the in vitro and in vivo experiments using
FGF9 - overexpressing
CRC cell lines ,
FGF9 overexpression induced strong resistance to anti -
EGFR therapies via the enforced
FGFR signal , and this resistance was cancelled by the application of an
FGFR inhibitor . -
pubmed
Considering these results , the
FGF9 gene may play an important role in resistance to anti -
EGFR therapies in
patients with
CRC , and such resistance might be overcome by combined treatment with an anti -
FGFR inhibitor . -
pubmed
These findings strongly encourage the development of
FGFR - targeted therapy for
CRC patients with
FGF9 gene upregulation . -
pubmed
The total
bilirubin , direct
bilirubin and
tumor markers (
CA-199 , CA-242 ,
CEA ) before and after surgery , the biliary stent patency status was assessed , and the survival time was evaluated . -
pubmed
KEY WORDS : Angiogenesis ;
Atherosclerosis ;
nicotinic acetylcholine receptors (
nAChRs ) ;
Nicotine . -
pubmed
METHODS : Premenopausal
women with
estrogen receptor - positive
breast cancer treated with definitive surgery were enrolled after completion of neoadjuvant or adjuvant chemotherapy . -
pubmed
Ovarian function was assessed at the time of enrollment and every 6 months for 2 years by
follicular - stimulating hormone levels and
bleeding history . -
pubmed
DISCUSSION : This study will provide evidence of the benefit of OFS plus
tamoxifen compared with
tamoxifen only in premenopausal
patients with
estrogen receptor - positive
breast cancer treated with chemotherapy . -
pubmed
Importantly , these data provide insight into a homeostatic mechanism in which
C1q and
HMGB1 can cooperate to terminate
inflammation , and which may be impaired in
C1q - deficient patients with
autoimmune disease . -
pubmed
Daratumumab (
DARA ) , a monoclonal antibody (
MoAb ) , was developed to treat
relapsed / refractory multiple myeloma (
RRMM ) . -
pubmed
Changes in
interleukin-6 levels during electroconvulsive therapy may reflect the therapeutic response in
major depression . -
pubmed
OBJECTIVE :
Interleukin-6 (
IL-6 ) has been reported to be elevated in
major depressive disorder (
MDD ) but decreased by antidepressive medication . -
pubmed
IL-6 levels are markedly elevated both after
epileptic seizures and single electroconvulsive therapy ( ECT ) session , but long - term changes in
IL-6 levels after ECT have not been studied . -
pubmed
Interestingly , the long - term effect of ECT on
IL-6 seems to correlate with outcome , providing further evidence of the mechanism of action of ECT and supporting the
inflammation theory in
MDD . -
pubmed
Cystic Fibrosis (
CF ) is a disease caused by mutations in the
cystic fibrosis transmembrane conductance regulator (
CFTR ) gene . -
pubmed
Lentiviral Transfer of
gamma - Globin with Fusion Gene
NUP98 -
HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates
Murine beta - Thalassemia . -
pubmed
Expression of
PHLDA2 was higher in
IVF than AI samples ( P<0.05 ) . -
pubmed
The
cytotoxic effect of
PNC-27 was dependent on its binding to
MDM-2 . -
pubmed
A total of 120 overweight ( body mass index & gt;23 kg / m2 )
inpatients ( aged 20 - 70 years ) with a history of
troponin - positive
acute coronary syndrome ( ACS ) within the 1 month preceding the study will be recruited . -
pubmed
Phenotypic Characterization of
EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With
Pulmonary Arterial Hypertension . -
pubmed
Heterozygous mutations in the gene encoding the
bone morphogenetic protein receptor type 2 (
BMPR2 ) are the commonest genetic cause of
PAH , whereas biallelic mutations in the
eukaryotic translation initiation factor 2 alpha kinase 4 gene (
EIF2AK4 ) are described in
pulmonary veno - occlusive disease /
pulmonary capillary hemangiomatosis . -
pubmed
Biallelic mutations in
EIF2AK4 were identified in 5 patients with a clinical diagnosis of
pulmonary veno - occlusive disease /
pulmonary capillary hemangiomatosis . -
pubmed
Furthermore , 9 patients with a clinical diagnosis of
PAH carried biallelic
EIF2AK4 mutations . -
pubmed
These patients had a reduced transfer coefficient for
carbon monoxide ( Kco ; 33 % [ interquartile range , 30%-35 % ] predicted ) and younger age at diagnosis ( 29 years ; interquartile range , 23 - 38 years ) and more interlobular septal thickening and
mediastinal lymphadenopathy on computed tomography of the chest compared with patients with PAH without
EIF2AK4 mutations . -
pubmed
Patients with
PAH with biallelic
EIF2AK4 mutations had a shorter survival . -
pubmed
CONCLUSIONS : Biallelic
EIF2AK4 mutations are found in patients classified clinically as having idiopathic and heritable
PAH . -
pubmed
The results revealed 39 mutations in the three
esophageal cancer cell lines ; the genes with the highest mutation frequencies included mitochondrially encoded
cytochrome B (
MT - CYTB ) ,
NADH dehydrogenase 5 (
MT - ND5 ) and
MT - ND4 gene . -
pubmed
A total of 216 mutations were identified in the 30
esophageal cancer tissues , including 182 protein - coding mutations , of which
MT - CYTB and
MT - ND5 genes exhibited higher mutation frequencies . -
pubmed
The Achilles tendons of 16 weeks old female
Sprague Dawley rats ( n = 40 ) were unloaded for 5 weeks by inducing
muscle paralysis with
botulinum toxin injections in the right gastrocnemius and soleus muscles . -
pubmed
Thus ,
Rac GTPase and
PAK proteins may serve as targets for treatment of fear and
anxiety disorders . -
pubmed
Myoglobulin released from dead muscle is shown to induce
acute kidney injury through a mechanism dependent on platelets and macrophage extracellular traps . -
pubmed
METHODS : In 58 hemodialysed
patients with
sHPT (
parathyroid hormone [
PTH ] & gt ; 300 pg / mL )
plasma Advanced Oxidation Protein Products (
AOPP ) , serum total antioxidant capacity - ImAnOx ( TAS /
TAC ) ,
serum PTH ,
calcium and
phosphate concentrations were assessed before the first dose of
cinacalcet and after 6 months of treatment . -
pubmed
MANF improves the
MPP+/
MPTP - induced
Parkinson ' s disease via improvement of mitochondrial function and inhibition of oxidative stress . -
pubmed
OBJECTIVE : This study aimed to investigate the therapeutic effect of
mesencephalic astrocyte - derived neurotrophic factor (
MANF ) on the
MPTP /
MPP+-induced model of
Parkinson ' s disease (
PD ) and the potential mechanism . -
pubmed
A cell model of
PD was established by incubating
SH - SY5Y cells with
MPP + , cells were pretreated for 2 h with different concentrations of
MANF before 24 h incubation with
MPP + . -
pubmed
CONCLUSION :
MANF can attenuate the
neuronal lesion in
MPTP /
MPP+-induced
PD mice , which may be related to the improvement of mitochondrial function and inhibition of oxidative stress . -
pubmed
We immunize
mice with
myelin oligodendrocyte glycoprotein (
MOG ) , DNA - histone and DNA - methylated
bovine serum albumin (
met - BSA ) complexes to reveal different characteristics of
EAE development including bone marrow lymphocyte proliferation and differentiation profiles of hematopoietic stem cells . -
pubmed
Immunization of
C57BL / 6 mice with
MOG35 - 55 results in the acceleration of
EAE development . -
pubmed
During the acute
EAE phase ( 7 - 20 days after immunization ) , catalytic antibodies efficiently hydrolysing
myelin basic protein (
MBP ) ,
MOG and DNA are produced with parallel suppression of antibodies hydrolysing histones . -
pubmed
We could show that in contrast to
MOG , immunization with histone - DNA results in a reduction of
proteinuria , a significant increase in anti - DNA ,
anti - MBP and anti -
MOG antibody titres , as well as an increase in their catalytic activities for antigen hydrolysis , but slightly changes the concentration of
cytokines . -
pubmed
DNA - histone stimulates the appearance of histone - hydrolysing abzymes in the acute
EAE phase , while abzymes with
DNase activity appear at significantly later time - points . -
pubmed
We conclude that
MOG , DNA - histone and
DNA - met - BSA have different effects on numerous bone marrow , cellular , immunological and biochemical parameters of immunized
mice , but all
antigens finally significantly stimulate the development of the
EAE . -
pubmed
Combining DNA Vaccine and
AIM2 in H1 Nanoparticles Exert Anti -
Renal Carcinoma Effects via Enhancing Tumor - Specific Multi - functional
CD8 + T - cell Responses . -
pubmed
In this study , we designed a
folate - grafted
PEI600 -
CyD ( H1 ) nanoparticle - mediated DNA vaccine containing an adjuvant of absent in melanoma 2 ( AIM2 ) and a tumor - specific antigen of
carbonic anhydrase IX (
CAIX ) for
renal carcinoma therapy . -
pubmed
Mice bearing subcutaneous
human CAIX ( hCAIX)-Renca
tumor were intramuscularly immunized with H1 - pAIM2 / pCAIX , H1 - pCAIX , H1 - pAIM2 , or Mock vaccine , respectively . -
pubmed
Lung metastasis of
renal carcinoma was also suppressed by H1 - pAIM2 / pCAIX vaccine treatment accompanied with the increased percentages of
CAIX - specific multi - functional CD8 + T cells in the spleen ,
tumor , and bronchoalveolar lavage as compared with
H1 - pCAIX vaccine . -
pubmed
Therefore , these results indicated that
H1 - pAIM2 / pCAIX vaccine exhibits the therapeutic efficacy of
anti - renal carcinoma by enhancing tumor - specific multi - functional
CD8 + T - cell responses . -
pubmed
PLCB1 Biallelic Point Mutations Cause
West Syndrome . -
pubmed
CONCLUSIONS : While the phenotype and true clinical effect of
AMR remain to be better defined , the high prevalence of DSA and the correlation with acute rejection highlight the need for optimizing immunosuppression , close monitoring and the relevance of an
HLA class II match in UET recipients . -
pubmed
OBJECTIVE : To assess the safety and efficacy of
crisaborole 2 % ointment - a nonsteroidal ,
phosphodiesterase-4 inhibitor - in the treatment of
intertriginous , anogenital , and facial psoriasis . -
pubmed
A study in
nonhuman primates reported that infusions of an antibody against
alpha4beta7 integrin , in combination with antiretroviral therapy , showed consistent , durable control of
simian immunodeficiency virus (
SIV ) in
rhesus macaques . -
pubmed
Taken together , these findings suggest that low doses of active
P1G10 promotes lesion resolution , at least in part by its anti - inflammatory activity , in TNBS -
colitis model . -
pubmed
The
sialidase activity of
NA is required for the release of nascent virus particles from infected cell membranes and inhibition of NA enzymatic activity can significantly reduce virus titers and duration of
infection . -
pubmed
RESULTS : Postoperatively , the concentrations of blood
glucose declined , and the
insulin sensitivity increased significantly in
rats with
diabetes . -
pubmed
METHODS AND RESULTS : This study aimed to evaluate the capabilities of three methods for genotyping
MTB isolates collected from Iran through comparing our previously published results for IS6110 - RFLP and PGRS - RFLP methods and current results obtained from IS6110 - Mtb1 /
Mtb2 PCR technique . -
pubmed
METHODS :
SARS - CoV-2 antibodies were measured with the Elecsys assay and the EDITM ELISAs (
IgM and
IgG ) in 64
SARS - CoV-2 RT - PCR confirmed
COVID-19 patients with serial blood samples ( n = 104 ) collected at different time points from symptom onset . -
pubmed
Prenatal
androgen ( PNA ) exposure mimics
reproductive dysfunction of the common
fertility disorder polycystic ovary syndrome (
PCOS ) and reduces prepubertal
GnRH neuron activity . -
pubmed
This provides a clearer understanding of the role prepubertal
GnRH neuron activity plays in establishing adult reproductive function and suggests additional
androgen - dependent programming actions are required for complete reproductive disruption in this model and perhaps
PCOS . -
pubmed
Here we set out to characterize the expression status of
LINC00426 in
osteosarcoma and understand its mechanistic involvement in incidence of
doxorubicin (
Dox ) resistance . -
pubmed
RESULTS :
LINC00426 was significantly up - regulated in
Dox - resistant
osteosarcoma ( OS ) both in vitro and in vivo , which intimately associated with unfavorable prognosis . -
pubmed
We uncovered the important contribution of
LINC00426 / miR-4319 to
Dox resistance in
osteosarcoma . -
pubmed
Focal adhesion kinase (
FAK ) is one kind of
tyrosine kinases that modulates
integrin and growth factor signaling pathways , which is a promising therapeutic target because of involving in the migration , proliferation and survival of
cancer cell . -
pubmed
Overexpression and amplification of
cyclin - dependent kinase 4 / 6 (
CDK4 / 6 ) occur in many
cancers and may be the cause of resistance to
CDK4 / 6 inhibitors in preclinical models . -
pubmed
N - acetylgalactosaminyltransferase : a potential target for colorectal
adenocarcinoma . -
pubmed
We employed
cystathionine beta synthase ;
CBS deficient mouse ; CBS+/- fed with / without HMD and with / without a probiotic in drinking water for 16 weeks . -
pubmed
Identification of a novel
KMT2A /
GIMAP8 gene fusion in a pediatric patient with
acute undifferentiated leukemia . -
pubmed
While commonly observed in several
acute leukemias ,
KMT2A rearrangements in
AUL have been rarely reported in the literature . -
pubmed
We report the third case to our knowledge of
AUL harboring a
KMT2A rearrangement . -
pubmed
Wnt Signaling Shapes the Histological Variation in Diffuse
Gastric Cancer . -
pubmed
For genetic modeling of diffuse
gastric cancer , we knocked out
CDH1 and/or
TP53 in human
normal gastric organoids . -
pubmed
The transition from PCC - NOS to
SRCC histology reflected the abundance of surrounding
R - spondin - expressing fibroblasts . -
pubmed
CONCLUSIONS :
SRCC and PCC - NOS were clonally identical , and their morphology was regulated by extracellular Wnt and
R - spondin expression . -
pubmed
BACKGROUND : We performed exploratory analyses of retinal thickness data from a clinical trial of the
AbetaPP cleaving enzyme (
BACE ) inhibitor
verubecestat in
patients with
Alzheimer ' s disease (
AD ) . -
pubmed
OBJECTIVE : To evaluate : 1 ) possible retinal thickness changes following
BACE inhibition ; and 2 ) possible association between retinal thickness and
brain atrophy . -
pubmed
CONCLUSION :
BACE inhibition by
verubecestat was not associated with adverse effects on retinal thickness in
patients with mild - to - moderate
AD . -
pubmed
ACTH - secreting
lung tumours . -
pubmed
delta - aminolaevulinic acid dehydratase activity and focal
brain haemorrhages in
lead - treated
rats . -
pubmed
It is concluded that damage to the
rat brain vascular system is a better index of lead
toxicity than measurement of the lead sensitive enzyme
ALA dehydratase . -
pubmed
Effects of
endothelin in portal
hypertensive rats . -
pubmed
Effects of
endothelin-1 on systemic arterial blood pressure , heart rate and portal venous pressure were compared in normal
Sprague - Dawley rats and
rats with portal
hypertension induced by
CCl4 and partial portal vein ligation . -
pubmed
The ability of
endothelin-1 to increase the portal venous pressure was also significantly diminished in portal
hypertensive rats . -
pubmed
It was concluded that a lower plasma level of
endothelin and a reduced vascular responsiveness may contribute , at least in part , to the hyperdynamics of portal
hypertension . -
pubmed
An important role of
gamma interferon may be to protect lymphohaemopoietic cells from
virus infection and destruction by cytopathic effects of either the virus or of anti - viral immunity . -
pubmed
Differential factor binding at the promoter of
early baculovirus gene PE38 during
viral infection : GATA motif is recognized by an insect protein . -
pubmed
Several factors would not seem to play an important prognostic role : age , liver function ,
alpha fetoprotein level or histological staging of the
tumor . -
pubmed
Serum transferrin levels in the longitudinal assessment of protein - energy status in
preterm infants . -
pubmed
c - H - ras-1 expression in
7,12 - dimethyl benzanthracene - induced Balb / c
mouse mammary hyperplasias and their
tumors . -
pubmed
Dimethylbenzanthracene (
DMBA)-induced
mouse mammary tumors characteristically contain an activated
c - H - ras-1 gene with an A----T transversion in the 61st codon which is expressed as a rapidly migrating
p21 c - H - ras . -
pubmed
The role of the activated
c - H - ras-1 locus in the initiation of
mammary neoplasia was analysed by studying seven transplantable ,
DMBA - induced Balb / c premalignant
mammary hyperplasias . -
pubmed
The DNAs from these
hyperplasias had no evidence of activation of the
c - H - ras-1 gene . -
pubmed
All of the
tumors with the characteristic mutation expressed the corresponding rapid
p21 c - H - ras . -
pubmed
These data suggest that although
c - H - ras-1 activation may play an important role in neoplastic progression , it had no definable role in the initiation or the maintenance of the
mammary hyperplasias studied here . -
pubmed
Linkage and segregation analyses of
apolipoproteins A1 and B , and lipoprotein
cholesterol levels in a large pedigree with excess
coronary heart disease : the Bogalusa Heart Study . -
pubmed
[ Behavior of
CK - MB in
uremic patients undergoing periodic hemodialytic treatment . -
pubmed
[ Use of
cocarboxylase in
steroid diabetes mellitus ] . -
pubmed
To study the mechanisms of the antiaggregation action of
thyroxine and
insulin , platelets obtained from
patients with
diffuse toxic goiter and from
rabbits with experimental
hyperinsulinemia were incubated with
acetylsalicylic acid and
indomethacin . -
pubmed
Based on the data obtained a hypothesis is advanced according to which
thyroxine inhibits the
platelet aggregation , interfering with the release of
arachidonic acid from
phospholipids of platelets (
thrombocytopathy A ) , whereas
insulin -- by blocking the
cyclooxygenase activity (
thrombocytopathy B ) . -
pubmed
Serum lipoproteins of
diabetic rats fed a high
cholesterol diet . -
pubmed
Feeding a diet containing 2 %
cholesterol and 1 %
cholic acid ( wt / wt ) to
rats made
diabetic by administration of
streptozotocin ( 45 mg / kg ) produced marked
hypercholesterolemia characterized by high concentrations of
very low density lipoproteins (
VLDL ) and
intermediate density lipoproteins (
IDL ) and a reduction in concentration of
high density lipoproteins (
HDL ) . -
pubmed
[ The
renin -
aldosterone profile in
hypertension ] . -
pubmed
Simultaneous study of
renin activity and
aldosterone concentration in the blood plasma of 180 out -
patients with
hypertensive disease has shown that
persons with normal or increased
reninemia predominate in the I stage of disease . -
pubmed
In stage II of
hypertensive disease
renin activity diminishes and the concentration of
aldosterone in blood plasma rises ,
aldosteronerenin index is enhanced at the expense of
aldosterone predominance , which is most often seen in the sub - group of
patients with low
reninemia . -
pubmed
Aldosterone - renin index correlates positively with the duration of
hypertensive disease . -
pubmed
Hypertensive crisis resulting from
avocados and a
MAO inhibitor . -
pubmed
Bcl-2 expression did not inhibit
Fas - mediated
cytotoxicity triggered by cells expressing
FasL or by the transient transfection of
human Fas . -
pubmed
In contrast , expression of
CrmA , a
cowpox virus protein that inhibits
ICE - like protease activity , blocked activation - induced apoptosis in
2B4 cells but had little effect on
Dex - mediated
cytotoxicity . -
pubmed
Cytotoxic necrotizing factor type 2 (
CNF2 ) produced by
Escherichia coli strains isolated from
intestinal and extraintestinal infections is a dermonecrotic toxin of 110 kDa . -
pubmed
We cloned the
CNF2 gene from a large plasmid carried by an
Escherichia coli strain isolated from a
lamb with
septicemia . -
pubmed
Gastric inhibitory polypeptide secretion after gastrectomy in
patients with
diabetes mellitus . -
pubmed
Gastric inhibitory polypeptide (
GIP ) secretion after distal gastrectomy was compared between
patients with
diabetes mellitus (
DM - group ) and
patients with normal
glucose tolerance ( N - group ) . -
pubmed
These findings suggest that
GIP secretion in
diabetics becomes insufficient after gastrectomy . -
pubmed
Cell cycle - dependent expression of
TAP1 ,
TAP2 , and
HLA - B27 messenger RNAs in a
human breast cancer cell line . -
pubmed
TAP-1 and TAP-2 mRNAs were undetectable in quiescent , serum - deprived
human breast cancer cells (
21PT ) . -
pubmed
Using conventional riboprobe in situ hybridization ,
ER transcripts were not detectable in any bone cells within sections taken from
normal bone and several actively remodeling bone tissues , namely ,
Paget ' s disease ,
renal hyperparathyroidism , and healing
fracture callus . -
pubmed
Successful engraftment after primary graft failure in
aplastic anemia using
G - CSF mobilized peripheral stem cell transfusions . -
pubmed
A 19 - year - old male underwent allogeneic BMT for severe
aplastic anaemia (
SAA ) from his
HLA- and blood group - identical sister . -
pubmed
Single - cell analysis of intrathyroidal lymphocytes shows differential
cytokine expression in
Hashimoto ' s and
Graves ' disease . -
pubmed
However , the larger T lymphocytes , presumably activated and responsible for the
autoimmune damage , predominantly produced
IL-4 in
GD and
IFN - gamma in
HT . -
pubmed
The specificity of the Th2 responses in
GD was suggested by the enrichment in
IL-4 production after antigen - specific expansion of two
oligoclonal T cell lines . -
pubmed
It has been proposed that
L - selectin and
Mac-1 (
CD11b / CD18 ) , two
neutrophil adhesion receptors , have sequential roles in neutrophil extravasation during
inflammation . -
pubmed
Administration of the
cytokine interleukin-2 (
IL-2 ) can result in therapeutic benefits for
individuals with
renal cell carcinoma and
melanoma . -
pubmed
Here we report an analysis of the
transcription factor families AP-1 ,
Sp1 ,
NF - kappaB , and
signal transducers and activators of transcription (
STAT ) in
cancer patients ' lymphocytes before and after
IL-2 immunotherapy , as assessed by a gel - shift assay . -
pubmed
Increasing plasma
neopterin and persistent plasma
endothelin during follow - up after acute
cerebral ischemia . -
pubmed
To evaluate the concentrations of a specific marker for macrophage activation ,
neopterin , and the potent endothelial derived vasoconstrictive peptide
endothelin-1 (
ET-1 ) , during the acute and chronic stages of
cerebral ischemia , plasma concentrations of
neopterin and
ET-1 were measured in 59
patients with acute
cerebral infarction or
transient ischemic attack ( median age 73 years , range 43 - 93 , 27
men ) and after a 1 - year follow - up in 57/59 ( 97 % ) of
patients . -
pubmed
Inactivation or mutation in
p53 gene is also known to result in loss of control over the cell cycle and increases in
tumor proliferation rates . -
pubmed
The present study examines the role of
HPV infection in relation to
p53 and the extent of the
tumor proliferative compartment reflected by
cyclin D1 and
Ki-67 expression during various phases of
tumor progression in the oral epithelium . -
pubmed
Expression of the
tumor suppressor
p53 protein also showed significant positive correlation with histology ( r = 0.475 , P = 0.00004 ) . -
pubmed
The
tumor proliferative fraction also increased with the extent of histological abnormality ( r = 0.387 , P = 0.0003 for
cyclin D1 and r = 0.463 , P = 0.0001 for Ki 67 ) . -
pubmed
Accumulation of
p53 and increase in
tumor proliferation also correlated to the presence of
HPV infection ( r = 0.511 , P = 0.00003 for
p53 ; r = 0.478 , P = 0.00002 for
cyclin D1 and r = 0.521 , P = 0.00004 for
Ki-67 ) . -
pubmed
The partial primary structure of an Mr 24,000 non -
haemorrhagic metalloproteinase isolated from the venom of the snake
Lachesis stenophrys has been determined . -
pubmed
Interestingly , it has almost identical sequence as the
metalloproteinase from
Lachesis muta muta ,
LHF - II , which is , however ,
haemorrhagic . -
pubmed
Louse - borne relapsing fever , caused by
Borrelia recurrentis , provides one of the best documented examples of the causative role of
tumor necrosis factor (
TNF ) in the pathology of severe
infection in
humans . -
pubmed
This review examines the potential pathophysiological involvement of one such developmental gene
gremlin in
diabetic nephropathy . -
pubmed
Immunohistochemically ,
tumor cells were invariably positive for
vimentin and
CD99 , and mostly for
CD34 but negative for
desmin ,
keratin ,
CD31 ,
CD117 (
c - kit ) , and
inhibin . -
pubmed
About half of the
tumors showed reactivity for
bcl-2 . -
pubmed
Vascular endothelial growth factor (
VEGF ) has a central role in normal as well as in
tumor angiogenesis . -
pubmed
Like
VEGF , the translation of the new isoforms is not sensitive to stress signals such as
anoxia . -
pubmed
P - selectin is an endothelial cell adhesion glycoprotein expressed on the cell surface early in
inflammation where it binds to blood leukocytes . -
pubmed
METHODS : Amplification refractory mutation system ( ARMS ) was used to detect
beta - thalassaemia ,
haemoglobin E and sickle cell mutations . -
pubmed
Factors associated with progression of
IgA nephropathy . -
pubmed
Fifty - two ( 30
adults and 22
children ) ( 29.8 % ) complained of mild adverse effects including an increase in
aspartate aminotransferase ( & gt;250 IU ) observed in 12 cases and considered related to
rifampin and in 11 cases a reversible
hyperpigmentation of the tongue attributed to
minocycline . -
pubmed
HCG tests in the management of
gestational trophoblastic diseases . -
pubmed
[ HORMONOGENESIS IN ENDEMIC AND SPORADIC
GOITERS ] . -
pubmed
Thus by using
yeast as a model system , we identified the molecular basis of the
respiratory defect caused by the disease mutations in
cytochrome b. -
pubmed
Elevated
interleukin-6 levels in cerebrospinal fluid of
vascular dementia patients . -
pubmed
PATIENTS AND METHODS : We examined the levels of
interleukin-6 (
IL-6 ) in the cerebrospinal fluid ( CSF ) of
patients with
Alzheimer ' s disease (
AD ) ( n = 26 ) ,
ischemic cerebrovascular disease without
dementia (
CVD ) ( n = 11 ) ,
vascular dementia (
VD ) ( n = 11 ) , and other
neurological disorders ( n = 21 ) using sensitive enzyme - linked immunosorbent assay . -
pubmed
RESULTS : The CSF concentrations of
IL-6 were significantly elevated in
patients with
VD compared with those of
patients with
AD or
CVD . -
pubmed
CONCLUSION : The CSF
IL-6 levels are increased in
patients with
VD , suggesting that inflammatory mechanisms may be involved in the development of
cognitive decline in some
patients with
cerebrovascular disease . -
pubmed
CSF
IL-6 may be a biological marker for
dementia in
cerebrovascular disease . -
pubmed
Dp71 expression is present in myoblasts but declines during myogenesis to avoid interfering with the function of
dystrophin , the predominant
Duchenne muscular dystrophy gene product in differentiated muscle fibers . -
pubmed
Women with
PCOS and the
MBS had significantly higher levels of serum free
testosterone ( P = 0.002 ) and lower levels of serum
SHBG ( P = 0.001 ) than women with
PCOS without the
MBS . -
pubmed
Women with
PCOS and the
MBS differ from their counterparts lacking the MBS in terms of increased
hyperandrogenemia , lower serum
SHBG , and higher prevalence of
acanthosis nigricans , all features that may reflect more severe
insulin resistance . -
pubmed
Are polymorphisms of
N - acetyltransferase genes susceptible to primary
liver cancer in Luoyang , China ? -
pubmed
AIM : To identify whether the polymorphisms of the
N - acetyltransferase (
NAT ) genes are susceptible to
primary liver cancer (
PLC ) in Luoyang , a PLC low - incidence area of China . -
pubmed
METHODS : The
NAT1 and
NAT2 genotypes of 96
PLC cases and 173 controls were determined by PCR - RFLP . -
pubmed
[ Expression of
glutathione S - transferase isoenzymes in
human gliomas ] . -
pubmed
The aim of present study was to analyze the expression pattern of
GST pi , mu (
mu4 and
mu5 ) and alpha at the mRNA and protein levels in
human primary gliomas . -
pubmed
RESULTS : There were no changes in
GST pi mRNA expression , determined by RT - PCR , between
gliomas and
tumor adjacent tissues . -
pubmed
However , using Western blotting method , an increase in
GST pi protein in
tumors was observed , which might be caused by the lower rate in protein degradation . -
pubmed
Decrease in the expression of
GST mu at mRNA level ( mu4 ) , as well as at protein level was shown in
gliomas compared to control tissues . -
pubmed
mRNA for
GST mu5 isoform was demonstrated only in two
tumor cases , but not in normal tissues , and for
GST alpha , in one sample of control tissue . -
pubmed
At the protein level ,
GST pi expression was increased in
gliomas , whereas
GST mu was decreased . -
pubmed
Regulatory role of host
CD8 + T lymphocytes in experimental
graft - versus - host disease across a single
major histocompatibility complex class II incompatibility . -
pubmed
We investigated the role of host
CD8 + T cells in experimental Th2 - type
graft - versus - host disease (
GVHD ) where donor / recipient disparity is restricted to a single
major histocompatibility complex ( MHC ) class II antigen . -
pubmed
METHODS :
Immunoglobulin ( Ig ) E serum levels ,
eosinophilia and lymphoid tissue
hyperplasia were compared after injection of bm12
CD4 + T cells in either wild - type or
CD8 + T cell - deficient (
CD8-/- ) C57BL/6
mice . -
pubmed
Increased serum levels of
IL-5 and
IL-13 in
CD8-/- hosts confirmed the enhancement of Th2 - type responses in the context of recipient
CD8 + T cell deficiency . -
pubmed
CONCLUSIONS : Host CD8 + T cells regulate alloreactive Th2 responses during
graft - versus - host disease through an
IFN - gamma dependent pathway , independently of the recognition of
beta2m - associated MHC class I molecules . -
pubmed
Pseudohypoparathyroidism (
PHP ) types Ia and Ic result from heterozygous inactivating mutations of
Gs alpha , the alpha - subunit of the heterotrimeric stimulatory
G - protein ,
Gs . -
pubmed
Collectively , data show
alpha - TEA to be a potent apoptotic inducer of both
cisplatin - sensitive and -resistant
human ovarian cancer cells via activating death receptor
Fas signaling and suppressing anti - apoptotic
AKT and
ERK targets . -
pubmed
As a marker for
PNEC /
NEB we used an antibody against
chromogranin A (
CGA ) , and computer - assisted morphometric analysis was employed to determine the relative frequency of PNEC per airway epithelial area ( % immunostained area , % IMS ) , the size of NEB , the number of nuclei / NEB , and the size of the NEB cells . -
pubmed
Protection from direct
cerebral cryptococcus infection by
interferon - gamma - dependent activation of microglial cells . -
pubmed
We have recently demonstrated that immunotherapy with
anti - CD40 and
IL-2 can protect
mice against disseminated
Cryptococcus infection . -
pubmed
These studies indicate that immunotherapy using
anti - CD40 and
IL-2 can augment host immunity directly in the brain against
C. - pubmed
Netrin G1 mutations are an uncommon cause of atypical
Rett syndrome with or without
epilepsy . -
pubmed
Mutations in the
methyl - cytosine - phosphate - guanosine dinucleotide ( CpG ) binding protein 2 gene are identified in up to 90 % of patients with classic
Rett syndrome . -
pubmed
However , the lack of
methyl - CpG binding protein 2 mutations in a small group of classic
Rett syndrome cases , and the low frequency of these mutations in atypical
Rett syndrome patients , suggest that other gene defects may play a role in this disorder . -
pubmed
One report described a patient with atypical
Rett syndrome who presented with
early epilepsy and a de novo translocation which disrupted the
Netrin G1 gene . -
pubmed
This study tested a sample of 91 female patients with a clinically heterogeneous phenotype ranging from
encephalopathy with
epilepsy to atypical
Rett syndrome without
epilepsy for mutations in the
Netrin G1 gene , to evaluate its involvement in this condition . -
pubmed
Our study suggests that
Netrin G1 is not involved in atypical
Rett syndrome or in unexplained
encephalopathy with
epilepsy , but in specific forms to be delineated better in the future . -
pubmed
Polymorphisms of the
IL1 - receptor antagonist gene (
IL1RN ) are associated with multiple markers of
systemic inflammation . -
pubmed
CONCLUSIONS : Common functional polymorphisms of the
IL1RN gene are associated with several markers of
systemic inflammation . -
pubmed
Change of cholinergic transmission and
memory deficiency induced by injection of
beta - amyloid protein into NBM of
rats . -
pubmed
The
impairment of memory after injection of
beta - AP(1 - 40 ) into NBM exhibited mainly the
deficiency of short - term working memory . -
pubmed
The results show that the injection of
beta - AP(1 - 40 ) into NBM impairs the cholinergic transmission in frontal cortex , and the impairment of cholinergic transmission may be the main cause of the
deficit of working memory . -
pubmed
The severity of
cholestasis and
hepatic injury was determined by changes in the plasma enzyme activities of
aspartate aminotransferase ,
alanine aminotransferase ,
gama glutamin transferase , and levels of total
bilirubin and direct
bilirubin . -
pubmed
Although one antagonist --
maraviroc , a
CCR5 inhibitor to treat
AIDS -- has been registered as an approved drug , this is the only success so far . -
pubmed
One low molecular weight , weakly active
purine template hit was progressed by iterative structure - based design to give submicromolar
pyrazolopyridines with good ligand efficiency and appropriate
CHK1 - mediated cellular activity in
HT29 colon cancer cells . -
pubmed
Steroidogenic factor-1 expression in
ovarian endometriosis . -
pubmed
Steroidogenic factor-1 (
SF-1 ) , a major protein regulating the complex cascade of steroidogenis , has been postulated to play a role in
ovarian endometriosis . -
pubmed
However , the expression in situ of
SF-1 in
ovarian endometriosis is unknown . -
pubmed
To shed light on its presence , the expression of
SF-1 was studied by immunohistochemistry in 30 cases of
ovarian endometriosis ( proliferative , n=15 ; secretory phase , n=15 ) and in 10 cases of
normal eutopic endometrium coming from the same patients . -
pubmed
No
SF-1 immunoreactivity was observed in glands or endometrial stroma from
ovarian endometriosis or eutopic endometrium . -
pubmed
Contrary to the earlier reported hypothesis , our data showed for the first time the absence of
SF-1 expression in glands and endometrial stroma from
ovarian endometriosis and eutopic endometrium . -
pubmed
However , the strong expression of
SF-1 observed in cortical and medullary ovarian mesenchymatous cells adjacent to
endometriosis , suggests a potential role for these cells in locally induced steroidogenesis . -
pubmed
[ Influence of
p75 neurotrophin receptor knockout on the regeneration of facial nerves after
crush injury in
mouse ] . -
pubmed
OBJECTIVE : To investigate the role of
p75 neurotrophin receptor (
p75NTR ) in the regeneration of facial nerve
crush injury . -
pubmed
CONCLUSION :
p75NTR plays an important role in the regeneration of injured peripheral nerves after
injury . -
pubmed
The analysis of fungal cells recovered from vaginal fluids of infected animals indicated that c - type was more prone to undergo morphogenesis and to express
SAP2 than b - type ; these different traits may account for the differences observed in the outcome of experimental rodent
vaginitis induced by the two
C. - pubmed
Role of
ZNRD1 (
zinc ribbon domain - containing 1 ) in angiogenesis of
leukaemia cells . -
pubmed
Here , we have first investigated the roles of
ZNRD1 in angiogenesis of
leukaemia . -
pubmed
The
leukaemia cell line
K562 was transfected with the vector that included the full - length cDNA of
ZNRD1 , then the growth and angiogenesis of cells were detected . -
pubmed
Up - regulation of
ZNRD1 could significantly inhibit the growth of cells , reduce
tumour microvessel densities and inhibit the
VEGF (
vascular endothelial growth factor ) production . -
pubmed
Taken together ,
ZNRD1 might inhibit
tumour angiogenesis and could be considered as a target for
leukaemia therapy . -
pubmed
Takayasu arteritis : anti -
TNF therapy in a Brazilian setting . -
pubmed
The aim of this study was to describe clinical features and response to different therapeutic interventions , including
anti - tumor necrosis factor (
TNF ) agents , in a case series of
Takayasu arteritis (
TA ) from Brazil . -
pubmed
Will newer
tyrosine kinase inhibitors have an impact in
AML ? -
pubmed
FLT3 inhibition has been a goal of
acute myeloid leukemia (
AML ) therapy since
FLT3 mutations were discovered to have a role in
AML . -
pubmed
Screening by a combination of fetal nuchal translucency and maternal serum free -
beta - human chorionic gonadotrophin and
pregnancy - associated plasma protein - A can identify about 90 % of fetuses with
trisomy 21 and other major aneuploidies for a false - positive rate of 5 % . -
pubmed
Induction of
ezrin - radixin - moesin molecules after cryogenic
traumatic brain injury of the
mouse cortex . -
pubmed
These results suggest that
ERM activation in the
injury penumbra is implicated in the inflammatory immune responses after
traumatic brain injury . -
pubmed
Anti - CD3 and anti -
cd16 monoclonal - antibody in - vitro enhancement of NK activity in pbl from
gastrointestinal - tract cancer -
patients . -
pubmed
Enhancement of cellular cytotoxicity by
anti - CD3 and
anti - CD16 may be of use in
cancer immunotherapy protocols . -
pubmed
Dried blood spots on filter paper as an alternative specimen for
measles diagnostics : detection of
measles immunoglobulin M antibody by a commercial enzyme immunoassay . -
pubmed
BACKGROUND : We compared the results of a serum - based measles
immunoglobulin M (
IgM ) test with results of tests using paired reconstituted dried filter paper blood spot ( DBS ) samples to assess the feasibility of using DBS samples for
measles diagnostic procedures . -
pubmed
The
transcription factor PHR1 (
PHOSPHATE STARVATION RESPONSE 1 ; encoded by gene
At4g28610 ) is central for adaptation to
phosphate deficiency in
Arabidopsis (
Arabidopsis thaliana ) . -
pubmed
A rapid turnover of
phosphate pools in the leaves is essential for energy transfer and metabolism within photosynthesis , and consequently , we hypothesized that
PHR1 is needed for adaptation to high - light stress during
P deficiency . -
pubmed
We conclude that
PHR1 is needed for the metabolic balance , for retaining P(i ) levels and for inducing
anthocyanin production , and during
P deficiency PHR1 is vital for adaptations to avoid permanent damage to
photosystems during high - light conditions . -
pubmed
In primary
human airway cells with ER stress resulting from
cystic fibrosis ,
D2 activity was absent . -
pubmed
This explains the lack of
D2 activity in primary
human airway cells with ER stress resulting from
cystic fibrosis . -
pubmed
A temple
skin rash ,
abnormal hepatic function and a remarkable elevated level of
serum ferritin occurred later in this
patient , which highly supported a potential diagnosis of
AOSD . -
pubmed
Novel cationic antimicrobial peptide GW - H1 induced
caspase - dependent apoptosis of
hepatocellular carcinoma cell lines . -
pubmed
Two - dimensional gel electrophoresis was applied to further analyze the
AMP - responsive protein profiles of
HCC , down - regulation of
Hsp27 ,
phophoglycerate kinase 1 and
triosephosphate isomerase indicated that GW - H1 may induce apoptosis , and further inhibit progression and metastasis of
J5 HCC cells . -
pubmed
These findings provided support for future application of
GW - H1 as potential therapeutic agent for
HCC . -
pubmed
Troponin release overestimates
infarct size in presence of
left ventricular hypertrophy . -
pubmed
Systemic inflammation , oxidative stress , elevated serum adipokines and
fetuin - A ,
metabolic acidosis ,
vitamin D deficiency , depressed
serum erythropoietin , endoplasmic reticulum stress , and suppressors of cytokine signaling all cause
IR by suppressing
insulin receptor -
PI3K -
Akt pathways in
CKD . -
pubmed
INTRODUCTION :
Ticagrelor , an oral
P2Y ( 12 ) receptor antagonist used as part of dual antiplatelet therapy in the treatment of
acute coronary syndromes (
ACS ) , has many favorable characteristics when compared with the more frequently used
P2Y ( 12 ) receptor antagonist
clopidogrel . -
pubmed
Kinetic analysis of
iron - dependent
histone demethylases :
alpha - ketoglutarate substrate inhibition and potential relevance to the regulation of
histone demethylation in
cancer cells . -
pubmed
Reported herein is a detailed kinetic analysis of three
JmjC -
HDMs , including the
cancer - relevant
JMJD2C , that was achieved by employing three enzyme activity assays . -
pubmed
JMJD2C displays an optimal activity in vitro at
alphaKG concentrations similar to those found in
cancer cells , with implications for the regulation of
histone demethylation activity in
cancer versus normal cells . -
pubmed
BACKGROUND :
Dexamethasone is widely used for
pulmonary exacerbation in
patients with
cystic fibrosis , however , not much is known about the effects of glucocorticoids on the
wild - type cystic fibrosis channel transmembrane regulator (
CFTR ) . -
pubmed
Neuregulin-1 signalling and antipsychotic treatment : potential therapeutic targets in a
schizophrenia candidate signalling pathway . -
pubmed
Evidence from genetic , transgenic and post - mortem studies have strongly supported
neuregulin-1 (
NRG1)-
ErbB4 signalling as a
schizophrenia susceptibility pathway . -
pubmed
NRG1 -
ErbB4 signalling plays crucial roles in regulating neurodevelopment and neurotransmission , with implications for the pathophysiology of
schizophrenia . -
pubmed
Post - mortem studies have demonstrated altered
NRG1 -
ErbB4 signalling in the brain of
schizophrenia patients . -
pubmed
Abnormal behaviours relevant to certain features of
schizophrenia are displayed in
NRG1 /
ErbB4 knockout
mice or those with
NRG1 /
ErbB4 over - expression , some of these abnormalities can be improved by antipsychotic treatment . -
pubmed
NRG1 -
ErbB4 signalling has extensive interactions with the GABAergic , glutamatergic and dopaminergic neurotransmission systems that are involved in the pathophysiology of
schizophrenia . -
pubmed
Furthermore , the key interaction points between
NRG1 -
ErbB4 signalling and other
schizophrenia susceptibility genes may also potentially provide specific targets for new antipsychotic drugs . -
pubmed
Fibulin-1 is down - regulated through promoter hypermethylation and suppresses
renal cell carcinoma progression . -
pubmed
Fibulin-1 , a multi - functional extracellular matrix protein , is involved in many types of
cancer but its function in
renal cell carcinoma is unclear . -
pubmed
We investigated
fibulin-1 expression and function in
renal cell carcinoma . -
pubmed
MATERIALS AND METHODS : We performed real - time polymerase chain reaction , Western blot analysis and immunohistochemistry to determine
fibulin-1 expression in
renal cell carcinoma cells and
patient tissues . -
pubmed
Eukaryotic expression plasmid and a lentiviral vector were used to over express
fibulin-1 in
ACHN and
786 - O renal cell carcinoma cells to investigate its function in vitro and in vivo . -
pubmed
RESULTS :
Fibulin-1 was significantly down - regulated in
renal cell carcinoma cell lines and
patient tissues . -
pubmed
Fibulin-1 over expression led dramatically to decreased cell growth , enhanced
tumor cell apoptosis , decreased cell motility and angiogenesis in cultured
renal cell carcinoma cells and in xenograft
tumors in
nude mice . -
pubmed
CONCLUSIONS :
Fibulin-1 is down - regulated in
renal cell carcinoma through promoter hypermethylation . -
pubmed
Efficacy and safety of
NMDA receptor antagonists augmentation therapy for
schizophrenia : an updated meta - analysis of randomized placebo - controlled trials . -
pubmed
Mutant
prolactin receptor and
familial hyperprolactinemia . -
pubmed
Galactose modified
trimethyl chitosan -
cysteine (
GTC ) conjugates with various
galactose grafting densities were developed for oral delivery of
Survivin shRNA - expression pDNA ( iSur - pDNA ) and
vascular endothelial growth factor (
VEGF ) siRNA ( siVEGF ) in the synergistic and targeted treatment of
hepatoma . -
pubmed
In tumor - bearing
mice , orally delivered GTC2 NPs could effectively accumulate in the
tumor tissues and silence the expression of
Survivin and
VEGF , evoking increased apoptosis , inhibited angiogenesis , and thus the most efficient
tumor regression . -
pubmed
Clinicians should consider
syncope ,
lightheadedness , and drop in
hemoglobin in absence of rectal
bleeding following a colonoscopy as possible warning signs of imminent or emergent
splenic injury . -
pubmed
SERPINs (
serine protease inhibitors ) are well known as negative regulators of hemostasis ,
thrombolysis , and innate immune responses . -
pubmed
CsSERPIN may take part in regulation of endogenous
serine proteinase and
CsSERPIN3 may be involved in immune evasion and be a potential candidate for vaccine and drug target for
clonorchiasis . -
pubmed
CONCLUSIONS : In
chronic lymphocytic leukemia , important biomarkers include expression of
CD38 and
ZAP-70 ,
IGVH mutational status , somatic mutations in
TP53 and
NOTCH1 , and abnormalities in chromosomes 11 , 12 , 13q , and 17 . -
pubmed
In
diffuse large B - cell lymphoma , important biomarkers include chromosomal rearrangement of
BCL2 ,
BCL6 , and
MYC and expression of
CD5 ,
BCL2 , and
CD43 , as well as somatic mutations in
TP53 and
BCL6 . -
pubmed
Association of functional polymorphisms in
interferon regulatory factor 2 (
IRF2 ) with susceptibility to
systemic lupus erythematosus : a case - control association study . -
pubmed
Previous linkage and association studies in European - American populations suggested genetic role of
IRF2 in
systemic lupus erythematosus (
SLE ) ; however , this observation has not yet been confirmed . -
pubmed
Here we investigated whether
IRF2 polymorphisms contribute to susceptibility to
SLE in a Japanese population . -
pubmed
Association study of 46
IRF2 tag single nucleotide polymorphisms ( SNPs ) detected association of an intronic SNP , rs13146124 , with
SLE . -
pubmed
In conclusion , our observations supported the association of
IRF2 with susceptibility to
SLE , and the risk haplotype was suggested to be associated with transcriptional activation of
IRF2 . -
pubmed
Cleaning up after
ICH : the role of
Nrf2 in modulating microglia function and
hematoma clearance . -
pubmed
Using primary microglia to model red blood cell ( main component of
hematoma ) clearance , we studied the role of
transcription factor nuclear factor - erythroid 2 p45 - related factor 2 (
Nrf2 ) , a master - regulator of antioxidative defense , in the
hematoma clearance process . -
pubmed
Using autologous blood injection
ICH model to measure
hematoma resolution , we showed that
Nrf2 activator ,
sulforaphane , injected to animals after the onset of
ICH , induced
CD36 expression in
ICH - affected brain and improved
hematoma clearance in
rats and wild - type
mice , but expectedly not in
Nrf2 knockout ( KO ) mice . -
pubmed
Normal
hematoma clearance was impaired in
Nrf2 - KO
mice . -
pubmed
Our experiments suggest that
Nrf2 in microglia play an important role in augmenting the antioxidative capacity , phagocytosis , and
hematoma clearance after
ICH . -
pubmed
Insulin - like Growth Factor-1 (
IGF-1 ): Demographic , Clinical and Laboratory Data in 120 Consecutive Adult
Patients with
Thalassaemia Major . -
pubmed
The aim of this study was to measure
IGF-1 values and other clinical data in a large number of adult
patients with
TM to evaluate the possible relationships between them . -
pubmed
PATIENTS AND METHODS : A cohort of 120 adult
patients with
TM was studied for plasma levels of
IGF-1 . -
pubmed
In these
patients endocrine complications and elevations of
aminotransferases (
ALT ) were more common compared to
TM patients with
IGF1 & gt ; -2SDs . -
pubmed
AGHD was diagnosed in 6 ( 4
males ) out of 11
patients ( 54.5 % ) who had
glucagon stimulation tests and in 5 out of 8 ( 62.5 % ) with
IGF-1 & lt;-2SD . -
pubmed
CONCLUSIONS : In 50 % of
TM patients the
IGF-1 levels were 2SDs below average values for healthy
individuals . -
pubmed
IGF-1 deficiency was more common in
TM patients with associated
endocrine complications , and a significant correlation was found in
HCV - RNA positive
females among
IGF-1 ,
ALT , and
serum ferritin . -
pubmed
Further data in a larger group of
patients are needed to confirm whether
IGF-1 level & lt;-2 SDs may be a potential criterion for additional studies in
TM patients . -
pubmed
A
p7 Ion Channel - derived Peptide Inhibits
Hepatitis C Virus Infection in Vitro . -
pubmed
As compared with
SCI group and sham control it was observed that
Angelica Sinensis significantly reduced the expression of
I - kBalpha and
NF - kB p65 , ( P<0.05 ) , while
MPO activity was also significantly reduced . -
pubmed
Clinical Validation of a Novel Commercial Reverse Transcription - Quantitative Polymerase Chain Reaction Screening Assay for Detection of
ALK Translocations and Amplifications in
Non - Small Cell Lung Carcinomas . -
pubmed
CONTEXT : -
EGFR mutations and
anaplastic lymphoma kinase (
ALK ) translocations have significant biologic and therapeutic implications in
lung cancers , particularly
lung adenocarcinomas . -
pubmed
The 2013 College of American Pathologists / Association for Molecular Pathology / International Association for the Study of Lung Cancer molecular testing guideline for
lung cancers recommend a testing algorithm in which detection of
ALK translocations using fluorescence in situ hybridization ( FISH ) is to be performed following testing for
EGFR mutations . -
pubmed
RESULTS : -We performed a retrospective review of cases previously tested by FISH and found that all FISH
ALK translocation - positive specimens were
RT - qPCR positive , and all FISH
ALK translocation - negative cases were
RT - qPCR negative ( the sensitivity and specificity of the
ALK RT - qPCR assay were 100 % ) . -
pubmed
CONCLUSION : -This assay allows rapid identification of
ALK alterations , can be performed in conjunction with
EGFR testing , and does not require use of valuable additional
tumor tissue . -
pubmed
Decreased expression of
mucin 18 is associated with unfavorable postoperative prognosis in
patients with
clear cell renal cell carcinoma . -
pubmed
BACKGROUND :
MUC18 is correlated with
tumor progression and metastasis in types of malignancy . -
pubmed
But the role of
MUC18 in
clear cell renal cell carcinoma remains unclear . -
pubmed
In this study , we aimed to investigate the expression of
MUC18 and its correlation with clinical outcomes in
clear cell renal cell carcinoma . -
pubmed
RESULTS :
MUC18 expression was significantly decreased in
tumor compared to non -
tumor tissue ( P<0.001 ) . -
pubmed
Lower
MUC18 expression in
tumor predicted a shorter survival time ( P=0.007 ) . -
pubmed
CONCLUSION :
MUC18 is an independent prognostic factor for
clear cell renal cell carcinoma and could be incorporated with the other parameters to predict 5- and 8 - year overall survival for
clear cell renal cell carcinoma patients . -
pubmed
In
HEK293 cells , miR-153 - 3p and miR-205 - 5p down - regulate
alpha - synuclein (
SNCA ) and
Leucine - rich repeat kinase 2 (
LRRK2 ) , two key proteins involved in
Parkinson ' s disease (
PD ) . -
pubmed
Many of the differentially expressed proteins are involved in diverse pathways including metabolism ,
neurotrophin signaling ,
actin cytoskeletal regulation ,
HIF-1 signaling and the proteasome indicating that miR-153 - 3p and miR-205 - 5p are involved in the regulation of a wide variety of biological processes in
neuroblastoma cells . -
pubmed
Peak height
thrombin levels showed a decrease over time in all
tumor types . -
pubmed
Patients who developed
VTE ( n = 14 ) showed increasing levels of
FVIII ,
sP - selectin , and D - dimer . -
pubmed
The author has reviewed the updated data of genetic aspects of
bAVMs , especially focusing on clinical and experimental knowledge from
hereditary hemorrhagic telangiectasia , which is the representative
genetic disease presenting with
bAVMs caused by loss - of - function in one of the two genes :
endoglin and
activin receptor - like kinase 1 . -
pubmed
Whole exome sequencing identifies a homozygous
POLG2 missense variant in an infant with
fulminant hepatic failure and mitochondrial DNA depletion . -
pubmed
Heterozygous mutations in
POLG2 were previously associated with
progressive external ophthalmoplegia and mtDNA deletions . -
pubmed
This is the first report of a patient with a homozygous mutation in
POLG2 and with a clinical presentation of severe
hepatic failure and
mitochondrial depletion . -
pubmed
Because of the small number of patients with
partial trisomy 21 , we addressed the question in the
Mouse in which three chromosomal regions located on MMU10 , MMU17 and MMU16 carries almost all the
HSA21 homologs . -
pubmed
Histopathology of tissue in reticulin - stained slide showed the presence of immature muscle fibers whereas Masson 's trichrome stain revealed
collagen fibers and smooth muscles confirming the diagnosis of oral midline subcutaneous smooth muscle (
leiomyomatous )
hamartoma of incisive papilla . -
pubmed
Hydrogen saline suppresses neuronal cell apoptosis and inhibits the
p38 mitogen - activated protein kinase -
caspase-3 signaling pathway following
cerebral ischemia -
reperfusion injury . -
pubmed
In the present study , we measured the levels of secreted
cytokines by effect or T cells in
TCE - treated
guinea pigs to better understand the contribution of
allergic disorders in
renal injuries . -
pubmed
Beyond
Human Leukocyte Antigen Class I Antigens :
Hereditary Hemochromatosis Gene Mutations in Recurrent
Aphthous Oral Ulcers and
Behcet Disease in the South of Tunisia . -
pubmed
OBJECTIVE : The aim of this work was to establish
human leukocyte antigen ( HLA ) class I and
hereditary hemochromatosis gene (
HFE ) mutation associations with recurrent
aphthous oral ulcers (
RAOU ) and
Behcet disease (
BD ) in a cohort of Southern Tunisian patients . -
pubmed
RESULTS :
HLA - B51 was positively associated with
BD , particularly in those with severe manifestations . -
pubmed
No association was detected with
HLA class I polymorphism among the
BD group . -
pubmed
Based on stratification to clinical manifestations , the isolated RAOU was negatively associated with
HLA - A1 with a difference close to significance ( 12 [ 14.81 % ] vs. 32 [ 26.02 % ] in
HCs ; p = 0.06 ) . -
pubmed
Considering
HFE mutations , patients with isolated
RAOU had a higher frequency of H63D when compared with other subgroups , especially after limiting the comparison to 27 patients of at least 5 years of follow - up . -
pubmed
CONCLUSION : This study showed that , unlike
BD , RAOU were not associated with
HLA - B51 . -
pubmed
RESULTS : Independent predictors of L-2 - ALNM by the multivariate logistic regression analysis included
tumor size ,
Ki-67 status , histological grade , and number of positive level 1 axillary lymph nodes . -
pubmed
IgG4 - related disease (
IgG4 - RD ) is an inflammatory condition characterized by a high serum
IgG4 concentration and the abundant infiltration of lymphocytes and
IgG4 - positive plasma cells in the tissue , as well as spatial ( diverse clinical manifestations ) and temporal ( the possibility of recurrence ) multiplicities . -
pubmed
Considering that
IgG4 -
RD was specified as being an intractable disease in 2015 , further studies are needed to clarify whether
IgG4 - RD is indeed a distinct disease entity or a complex of disorders of different etiologies and clinical conditions . -
pubmed
The expression levels of genes involved in inflammatory signaling (
TNFAIP2 ,
ACOT7 , and
RORA ) were also associated with birth weight , suggesting a role for inflammatory processes in
Cd - associated
reproductive toxicity . -
pubmed
Kinesin Spindle Protein (
KSP ) or
Eg5 is an essential kinesin that is involved in spindle separation process during mitosis and also unregulated in certain
cancer cells . -
pubmed
RESULTS :
CD4+TCM ,
CD4+TEM ,
CD8+TCM levels and
CD4+/
CD8 + TEM of
NSCLC patients were significantly lower than those of the control group , while
CD4+/
CD8 + TCM was significantly higher than that of the control group(all P<0.05 ) . -
pubmed
In
NSCLC patients ,
CD4+TCM ,
CD4+TEM and
CD8+TCM were decreased and
CD8+TEM levels were increased 4 weeks after radiotherapy(all P<0.05 ) ;
CD4+TCM ,
CD4+TEM and
CD8+TCM at 12 - week after radiotherapy were increased significantly compared with those at 4 - week after radiotherapy(all P<0.05 ) . -
pubmed
The short ( S ) allele of a functional polymorphism ( 5 - HTTLPR ) within the promoter region of the
serotonin transporter gene (
SLC6A4 ) is found to predispose the risk for stress - related
affective disorders relative to the long ( L ) allele . -
pubmed
P16INK4a gene promoter methylation as a biomarker for the diagnosis of
non - small cell lung cancer : An updated meta - analysis . -
pubmed
BACKGROUND : This meta - analysis was conducted to investigate the diagnostic performance of
P16INK4a gene promoter methylation as a biomarker of
non - small cell lung cancer (
NSCLC ) . -
pubmed
The pooled sensitivity , specificity , positive and negative likelihood ratios , and diagnostic odds ratio were 0.46 ( 95 % confidence interval [ CI ] 0.43 - 0.48 ) , 0.90 ( 95 % CI 0.88 - 0.91 ) , 6.33 ( 95 % CI 3.89 - 10.30 ) , 0.57 ( 95 % CI 0.50 - 0.65 ) and 10.72 ( 95 % CI 6.94 - 16.56 ) , respectively , for
P16INK4a gene promoter methylation as a biomarker for the diagnosis of
NSCLC . -
pubmed
CONCLUSION :
P16INK4a gene promoter methylation detection in serum or bronchoalveolar fluid / sputum may be a potential biomarker for
NSCLC diagnosis ; however , the sensitivity was relatively low , which is not suitable for
NSCLC screening . -
pubmed
We focused on one potential anti -
HCMV target ,
MAPK4 K , and identified lead compounds inhibiting
MAP4K4 that have anti -
HCMV activity with little cellular
cytotoxicity . -
pubmed
Chemical immunosuppressive drugs including
mammalian target of rapamycin inhibitors (
sirolimus and
everolimus ) ,
calcineurin inhibitors (
tacrolimus and
cyclosporine ) , and
purine and
pyrimidine synthesis inhibitors (
6 - mercaptopurine ,
mycophenolic acid , and
methotrexate ) are widely prescribed for the treatment of
autoimmune and inflammatory diseases and for controlling alloimmunity in interfering with the signals that activate and allow T cells to proliferate . -
pubmed
Royal Jelly Alleviates
Cognitive Deficits and
beta - Amyloid Accumulation in
APP /
PS1 Mouse Model Via Activation of the
cAMP /
PKA /
CREB /
BDNF Pathway and Inhibition of Neuronal Apoptosis . -
pubmed
Alzheimer ' s disease (
AD ) is characterized clinically by progressive
cognitive decline and pathologically by the accumulation of
amyloid - beta (
Abeta ) in the brain . -
pubmed
Importantly , hippocampal
cyclic adenosine monophosphate (
cAMP ) , p - PKA , p - CREB and
BDNF levels were significantly increased in the
APP /
PS1 mice after RJ treatment , indicating that the
cAMP /
PKA /
CREB /
BDNF pathway might be related to the ameliorative effect of RJ on
cognitive decline . -
pubmed
Repeated measures linear regression models estimated the
anemia - type associated change in the
CD4 cell - count , QOL , body mass index ( BMI ) and frailty over 18 months . -
pubmed
Cox proportional hazard models estimated associations between
anemia - type and time to ( a ) gain at least 100
CD4 cells / L and ( b ) hospitalization / death . -
pubmed
ACD incidence decreased by 53 % ( 95%CI : 0.27 - 0.79 ) per 100 cells / L increase in baseline
CD4 - cell count and decreased by 90 % ( 95%CI : 0.01,0.87 ) among adults treated with
nevirapine - containing HAART . -
pubmed
Macrocytic anemia did not predict a post - enrollment change in
CD4 , BMI or QOL during follow - up . -
pubmed
Glucose Oxidase - Based
Glucose - Sensitive Drug Delivery for
Diabetes Treatment . -
pubmed
The
glucose - sensitive drug delivery systems based on
glucose oxidase (
GOD ) , which exhibit highly promising applications in
diabetes therapy , have attracted much more interest in recent years . -
pubmed
METHODS :
Cytokine evaluation was performed via multiplex
cytokine array for 65 immune markers in plasma during the different phases of
hepatitis . -
pubmed
During the phase of detectable
HEV RNA in serum , there was a surge in
T - cell - related immune mediators , as well as
interferon alpha and
interferon gamma - induced protein 10 (
IP-10 ) , characteristic of a
viral infection . -
pubmed
After clearance of the virus in the blood and development of
cholestatic hepatitis , several inflammatory markers subsided , followed by an increase in
immune factors related to anti - inflammatory activity , as well as
monocyte / macrophage - related markers , likely due to the intrahepatic presence of the virus . -
pubmed
Tissue and Plasma
EGFR Mutation Analysis in the FLAURA Trial :
Osimertinib vs Comparator
EGFR - TKI as First - Line Treatment in
Patients with
EGFR Mutated Advanced
NSCLC . -
pubmed
PURPOSE : To assess the utility of the cobas
EGFR Mutation Test , with tissue and plasma , for first - line
osimertinib therapy for
patients with
EGFR - mutated (
EGFRm ) ( Ex19del and/or L858R ) advanced or metastatic
non - small cell lung cancer (
NSCLC ) from the FLAURA study ( NCT02296125 ) . -
pubmed
EXPERIMENTAL DESIGN :
Tumor tissue
EGFRm status was determined at screening using the central cobas tissue test or a local tissue test . -
pubmed
Baseline circulating
tumor ( ct)DNA
EGFRm status was retrospectively determined with the central cobas plasma test . -
pubmed
Lack of
EGFRm detection in plasma was associated with prolonged PFS vs
patients plasma
EGFRm positive , potentially due to
patients having lower
tumor burden . -
pubmed
In 25 cases molecular analysis was performed showing alterations in 21 patients : 6 cases with
AML / ETO , 3
PML / RAR , 7
Flt3 mutations ( 2 associated with
NPM1 mutation ) as well as 1 case of isolated mutation of
NPM1 and respectively
WT1 . -
pubmed
PARP Inhibitors for
Ovarian Cancer : Current Indications , Future Combinations , and Novel Assets in Development to Target DNA Damage Repair . -
pubmed
PARP inhibitors ( PARPIs ) have revolutionized the treatment of
epithelial ovarian cancer , first for
BRCA - associated cancer , and , recently , for all
epithelial cancers of serous or high - grade endometrioid subtypes in the front line . -
pubmed
BACKGROUND & AIMS : The I148 M variant in
PNPLA3 is the major genetic risk factor for
non - alcoholic fatty liver disease (
NAFLD ) . -
pubmed
Gene expression data indicate that
PNPLA3 is liver - specific in
humans , but whether it functions in adipose tissue (
AT ) is unknown . -
pubmed
We investigated whether
PNPLA3 - I148 M modifies AT metabolism in
human NAFLD . -
pubmed
RESULTS :
PUFA - TGs were significantly increased in
AT in carriers versus non - carriers of
PNPLA3 - I148M. -
pubmed
PNPLA3 mRNA was 33 - fold higher in the liver than in
AT ( p<0.0001 ) . -
pubmed
In contrast ,
PNPLA3 protein levels per tissue protein were 3 - fold higher in
AT than the liver ( p<0.0001 ) and 9 - fold higher when related to whole - body AT and liver tissue masses ( p<0.0001 ) . -
pubmed
CONCLUSIONS : Contrary to previous assumptions ,
PNPLA3 is highly abundant in
AT . -
pubmed
Changes in AT metabolism do not contribute to
NAFLD in
PNPLA3 - I148 M carriers . -
pubmed
Elevated
parathyroid hormone (
PTH ) concentrations were reported to be associated with
chronic renal allograft failure . -
pubmed
In
CKD patients , the majority of the circulating
PTH is oxidized . -
pubmed
Targeting Pharmacokinetic Drug Resistance in
Acute Myeloid Leukemia Cells with
CDK4 / 6 Inhibitors . -
pubmed
The therapy outcomes are often compromised by the existence of a resistant
AML phenotype associated with overexpression of
ABCB1 and
ABCG2 transporters . -
pubmed
In this study , we investigated the modulatory potential of the
CDK4 / 6 inhibitors
abemaciclib ,
palbociclib , and
ribociclib on
AML resistance using peripheral blood mononuclear cells ( PBMC ) isolated from
patients with de novo diagnosed
AML . -
pubmed
We first confirmed inhibitory effect of the tested drugs on
ABCB1 and
ABCG2 in
ABC transporter - expressing resistant HL-60 cells while also showing the ability to sensitize the cells to cytotoxic drugs even as no effect on
AML - relevant CRE isoforms was observed . -
pubmed
Expansion of the GAA / TTC repeats in the first intron of the
FXN gene causes
Friedreich ' s ataxia . -
pubmed
One of the latter ( rs13266634 ) locates in a
SLC30A8 exon , encoding a tryptophan - to - arginine substitution that decreases
SLC30A8 function , being the canonical explanation for
type 2 diabetes risk association . -
pubmed
However , other type 2
diabetes associated SNPs that truncate
SLC30A8 , confer protection to this disease , contradicting this explanation . -
pubmed
Analysis of rostral ventrolateral medulla gene expression confirmed the presence of ERS ,
inflammation , and activation of
renin -
angiotensin system pathways in high output
HF and showed that
TUDCA treatment completely abolished ERS and ERS - related signaling . -
pubmed
Exploiting the pro - resolving actions of glucocorticoid - induced proteins
Annexin A1 and
GILZ in
infectious diseases . -
pubmed
Although the role of
GILZ and
AnxA1 in the context of
infectious diseases remain to be better explored , herein we provide an overview of the emerging functions of these GC - proteins obtained from pre - clinical models of
infectious diseases . -
pubmed
PURPOSE : Diagnosis of
prostate cancer (
CaP ) is based on digital rectal examination ( DRE ) and/or elevated
prostate specific antigen (
PSA ) level . -
pubmed
Response to comments on : Short - term outcome of
botulinum neurotoxin A injection with or without
sodium hyaluronate in the treatment of
infantile esotropia - A prospective interventional study . -
pubmed
Regulation of
valproic acid induced EMT by
AKT /
GSK3beta /
beta - catenin signaling pathway in triple negative
breast cancer . -
pubmed
Valproic acid (
VPA ) is a selective histone deacetylation (
HDAC ) inhibitor and exerts anti - cancer properties in different types of
cancer . -
pubmed
Therefore , we aimed to clarified the unravel relationship between
AKT /
GSK3beta /
beta - catenin signalling pathway and
VPA - induced EMT in triple negative
breast cancer (
TNBC ) . -
pubmed
Additionally ,
Annexin V , cell cycle and
wound healing assays were performed . -
pubmed
Patients achieving SVR showed a significant decrease in the mean
serum alanine transaminase (
ALT ) levels ( 50.90 + -54.60 U / L to 17.00 + -14.50 U / L ) and model for
end - stage liver disease ( MELD ) scores ( 7.51 + -4.54 to 7.32 + -3.40 ) ( p<0.05 ) . -
pubmed
The most common adverse events were
fatigue ( 12.6 % ) ,
pruritis ( 7.3 % ) , increased serum
ALT ( 4.7 % ) and
bilirubin ( 3.8 % ) levels , and
anemia ( 3.1 % ) . -
pubmed
The activation of
Hageman factor , followed by complement cleavage leading to liberation of various chemical mediators , can be initiated by exposure of negatively charged tissue components due to
trauma and
infection . -
pubmed
The latter caused almost no change or a slight increase in serum lipid levels with a decrease in pre beta - lipoprotein and an increase in
alpha - lipoprotein , though it was not found in
MAP . -
pubmed
Acute
toxicity and pharmacology of
beta - human chorionic gonadotrophin conjugated tetanus toxoid ( Pr - beta - HCG - TT ) . -
pubmed
A mammary cell - specific enhancer in
mouse mammary tumor virus DNA is composed of multiple regulatory elements including binding sites for
CTF / NFI and a novel
transcription factor ,
mammary cell - activating factor . -
pubmed
The most important 9 parameters were scored according to the prognostic value as follows : age , proportion of blasts in bone marrow , blast count in peripheral blood , morphological subtype , percentage of granulocytes in bone marrow , proportion of blasts with
CD-15 antigen , thrombocyte count , spleen /
liver enlargement , protein concentration in cerebro - spinal fluid . -
pubmed
Reduction of
inflammation ,
tissue damage , and mortality in
bacterial meningitis in
rabbits treated with monoclonal antibodies against
adhesion - promoting receptors of leukocytes . -
pubmed
Intravenous injection of the
anti - CD18 mAb IB4 effectively blocked the development of
leukocytosis in the CSF of animals challenged intracisternally with living
bacteria ,
bacterial endotoxin , or
bacterial cell wall . -
pubmed
This effect was associated with protection from
blood brain barrier injury as measured by exclusion of
serum proteins from
CSF in mAb - treated animals . -
pubmed
Therapy with
mAb IB4 prevented development of
brain edema and death in animals challenged with lethal doses of
Streptococcus pneumoniae . -
pubmed
These studies indicate that the major mechanism of leukocyte migration across the blood brain barrier involves the
CD11 / CD18 receptors and that inflammatory leukocytes recruited by this mechanism are a major cause of
blood brain barrier injury and
cerebral edema during
meningitis . -
pubmed
Disposable
insulin syringes and
drug abuse . -
pubmed
Low activity of
angiotensin converting enzyme (
ACE ) has been reported in
patients with smoking related diseases , such as
chronic bronchitis ,
emphysaema and
carcinoma of the lung [ 1 ] but this has not been reported in healthy , chronic smokers . -
pubmed
The level of
fructose 2,6 - bisphosphate , a regulator of
phosphofructokinase activity , is decreased by 20 % in the
alloxan diabetic rat heart , this may be a significant additional factor in the marked decrease in the flux of
glucose through the glycolytic route in the myocardium in
diabetes . -
pubmed
The measurement of plasma levels of
human follicle - stimulating hormone (
FSH ) has proved to be of value for the study of the hypothalamic - hypophyseal - gonadal axis , greatly facilitating the diagnosis and mangement of problems relating to the menopause and
infertility . -
pubmed
To examine the relationship between the immune responses to
hydralazine , a drug known to induce
systemic lupus erythematosus , and to deoxyribonucleoprotein (
DNP ) we followed prospectively 21
hypertensive patients treated with
hydralazine for the first time . -
pubmed
In one
patient whose serum had a positive antinuclear antibody test prior to treatment , a mild
hydralazine systemic lupus erythematosus syndrome developed preceded by rises in the levels of both anti -
hydralazine and
anti - DNP . -
pubmed
Studies by radioimmunoassay on serums of three additional
patients , not followed in this study but known to have
hydralazine - induced
systemic lupus erythematosus , revealed no evidence for either ( 1 ) cross - reactivity between
anti - DNP and anti -
hydralazine or ( 2 ) antibodies specific for a
hydralazine -
DNP complex . -
pubmed
Mutations in the rod 1A domain of
keratins 1 and 10 in
bullous congenital ichthyosiform erythroderma (
BCIE ) . -
pubmed
Insulin - like growth factor - binding protein-3 production by
MCF-7 breast cancer cells : stimulation by
retinoic acid and
cyclic adenosine monophosphate and differential effects of
estradiol . -
pubmed
The
insulin - like growth factors (
IGFs ) stimulate the proliferation of
human breast cancer cells , including the
estrogen - dependent cell line MCF-7 . -
pubmed
These data demonstrate that modulating the production of
IGFBPs can lead to changes in the sensitivity of
breast cancer cells to IGFs , and as a result change the cell proliferative effects of these growth factors . -
pubmed
Dissecting the roles of the individual
IGFBPs is essential to understanding how such differential regulation will ultimately affect
IGF - stimulated cell proliferation in
breast cancer . -
pubmed
Specific
IgE were found most often in patients with
AD . -
pubmed
Immunohistochemical evaluation of
tenascin in benign
eccrine gland tumors : comparison with
laminin and
fibronectin . -
pubmed
Surgically resected specimens of
skin appendage tumors ,
spiradenoma ,
poroma of eccrine glands ,
syringoadenoma , syringoadenoma papilliferum and
mixec tumor of skin were evaluated for
tenascin , as well as the basement membrane - associated protein
laminin , and the extracellular matrix protein
fibronectin , using immunohistochemical methods . -
pubmed
Tenascin in
syringoadenoma was also expressed linearly adjacent to the basement membrane . -
pubmed
Mixed
tumors of skin showed a characteristic distribution of
tenascin in the modified myoepithelial cell area adjacent to the
tumor epithelia with a heterogeneous pattern , and particularly strong expression in the hyalinous and chondroid areas . -
pubmed
In addition , the localization of
laminin in the basement membranes of
tumors , intracellular immunoreactivity was observed in
syringoadenoma ,
syringocystadenoma papilliferum , and mixed
tumor of skin . -
pubmed
Fibronectin reactivity was visualized as a diffuse staining in the
tumor stroma of
eccrine poroma but its expression was restricted in
eccrine spiradenoma . -
pubmed
Tn and
sialyl - Tn carbohydrate structures , first identified in
glycophorins of persons with the rare
Tn syndrome , were found to be present on the surface of most
cancer cells . -
pubmed
In this article , the studies on
Tn and
sialyl - Tn antigens as diagnostic and prognostic
tumor markers and as immunogens in vaccines for
cancer immunotherapy are shortly reviewed . -
pubmed
Prompt institution of
corticosteroid treatment is regarded as indispensable at increase of
CRP / S - AA due to
infection or surgery . -
pubmed
PATIENTS AND METHODS : Twenty - two consecutive
patients with severe
anemia (
hemoglobin & lt ; 5 g / dl ) of gradual onset requiring transfusion of packed red blood cells ( PRBC ) were studied . -
pubmed
A
mouse ( BWTG3 ) and a
rat ( 7777 )
hepatoma , both of which exhibit characteristics of fetal hepatocytes , were found to contain
LPL mRNA , whereas the more differentiated
human (
Hep G2 and Hep 3B ) or
rat ( Fa32 )
hepatoma cell lines did not . -
pubmed
Somatic cell hybrids between
LPL - producing
hepatoma cells and non -
LPL - producing cells , such as adult
rat hepatocytes or fibroblasts , exhibited extinction of
LPL gene expression . -
pubmed
Intrathecal administration of recombinant
human superoxide dismutase 1 in
amyotrophic lateral sclerosis : a preliminary safety and pharmacokinetic study . -
pubmed
Two of the 16 subjects had familial
ALS and mutations in the gene for
Cu /
Zn SOD1 . -
pubmed
A few previous studies have described intrinsic
MRP expression in both
NSCLC and
normal lung tissues . -
pubmed
Using 15 unselected cell lines , we show that
MRP ( mRNA and protein as detected by reverse transcriptase polymerase chain reaction and immunoblot ) is frequently expressed intrinsically , with markedly varying intensity , in
NSCLC . -
pubmed
MxA overexpression reveals a common genetic link in four
Fanconi anemia complementation groups . -
pubmed
Expression of
osteopontin in
Meckel ' s cartilage cells during phenotypic transdifferentiation in vitro , as detected by in situ hybridization and immunocytochemical analysis . -
pubmed
Therefore , the soluble suppressing activity of CD8 + cells in
HIV-2 - infected baboons may be analogous to the
CD8 + cell antiviral factor described in
human HIV - infected asymptomatic people . -
pubmed
Association of plasma lipids and
apolipoproteins with the
insulin response element in the
apoC - III promoter region in
familial combined hyperlipidemia . -
pubmed
The
apoAI - CIII - AIV gene cluster , located on chromosome 11 , contributes to the phenotype of
familial combined hyperlipidemia (
FCH ) , but this contribution is genetically complex . -
pubmed
Combinations of haplotypes , based on three restriction enzyme polymorphisms : XmnI and
MspI sites , 5 ' of the start site of the
apoA - I gene and
SstI polymorphism in the 3 ' untranslated region of exon 4 of the
apoC - III gene , were analyzed to characterize their effect on the expression of severe
hyperlipidemia . -
pubmed
In the present study two additional polymorphic sites in the insulin response element ( IRE ) of the
apoC - III gene promoter , T-455C : FokI restriction site , C-482 T : MspI restriction site , were studied in 34
FCH pedigrees including 34 probands , 220
hyperlipidemic relatives , 300 normolipidemic relatives , and 236 spouses . -
pubmed
Analysis of combinations of haplotypes based on the five polymorphisms in the gene cluster provided further evidence for a dominant role of the
SstI polymorphism as a major susceptibility locus in
FCH . -
pubmed
BACKGROUND :
Cytokines mediate the metabolic and physiologic responses to injury and
infection . -
pubmed
CONCLUSION : Stimulation of pituicytes by
TNF or
IL-1 induces the release of
HMG-1 , which may participate in the regulation of neuroendocrine and immune responses to
infection or injury . -
pubmed
[ Changes in synthesis of
nitric oxide , blood levels of
ACTH and
cortisol in
viral hepatitis B ] . -
pubmed
A negative correlation between
nitrituria /
nitraturia and
ALAT ,
ASAT ,
bilirubin ,
alkaline phosphatase ,
gamma - glutamyl - transpeptidase is an indirect evidence for a protective role of
NO against
viral hepatitis B. -
pubmed
The influence of
pertussis toxin , a decisive virulence factor in the pathogenesis of
pertussis disease , on barrier integrity was investigated in model systems for blood - liquor ( epithelial ) and blood - brain ( endothelial ) barriers . -
pubmed
A recent study implicating the common stress mediator
NF - kappaB in
glaucoma would support this notion . -
pubmed
Clinical observations on
allergic sensitivity to
insulin . -
pubmed
GENERAL DEVELOPMENT AND PROGNOSTIC ELEMENTS OF
CIRRHOSIS ] . -
pubmed
[ TREATMENT OF
CORONARY CIRCULATORY DISORDERS WITH
ISOPTIN IN GENERAL PRACTICE ] . -
pubmed
Lifestyle changes as recommended in
diabetes are fundamental for treatment ; addition of
insulin - sensitising agents ( eg ,
metformin ) may be valuable in circumstances such as
anovulatory infertility . -
pubmed
Infertility can be treated successfully in most women by diet and exercise ,
clomiphene citrate with or without
metformin , ovarian drilling , or ovulation induction with
gonadotrophins ; in - vitro fertilisation should be avoided unless there are other indications . -
pubmed
Peri - sciatic proinflammatory
cytokines , reactive
oxygen species , and complement induce mirror - image
neuropathic pain in
rats . -
pubmed
Peri - sciatic injection of selective inhibitors / antagonists revealed that a number of immune products are early mediators of the resultant
allodynias , including proinflammatory
cytokines (
tumor necrosis factor ,
interleukin-1 , and
interleukin-6 ) , ROS , and complement . -
pubmed
[ A new treatment of
keratectasia after LASIK by using
collagen with
riboflavin / UVA light cross - linking ] . -
pubmed
RESULTS : Due to the induced
collagen cross - linking the biomechanical status of the cornea was stabilized and a progression of the
keratectasia was prevented . -
pubmed
The genotypes without
Px haplotype might exert some favorable effect on
BMD , while those with
Px haplotype may be harmful to bone -
pubmed
A
motor neuron disease - associated mutation in
p150Glued perturbs
dynactin function and induces protein aggregation . -
pubmed
B - type natriuretic peptide testing is an attractive and non - invasive tool in non - surgical
patients for the diagnosis of
heart failure , but its role in the perioperative period for the diagnosis of
myocardial contractile dysfunction is less clear . -
pubmed
For verification of a diagnosis of
cancer , high - molecular - weight
cytokeratin was still the most commonly used immunohistochemical marker ( 91 % ) , followed by
p63 ( 58 % ) and
alpha - methylacyl - CoA - racemase ( 50 % ) . -
pubmed
This may have relevance , for instance , to
cancer , as
HIF-1 overexpression is observed in many
human cancers and has been associated with increased
patient mortality . -
pubmed
Experimental studies have suggested that
angiotensin converting enzyme inhibitors and
calcium channel blockers may prevent or arrest progression of
renal injury . -
pubmed
Prostate - specific antigen doubling time is increasingly used as an indicator of
disease recurrence after local therapy and
prostate cancer - specific survival . -
pubmed
BACKGROUND : The positron emission tomography ( PET ) with
F18 17beta - estradiol (
FES ) has good imaging for assessment of
estrogen receptor in
breast cancer . -
pubmed
Oxygen sensing and redox signaling : the role of
thioredoxin in embryonic development and
cardiac diseases . -
pubmed
Here we discuss the roles of
TRX on
oxygen stress and redox regulation from different perspectives , in embryogenesis and in
adult diseases focusing on
cardiac disorders . -
pubmed
Based on the ability of NLAs to bind strongly to DNA through intercalation , we investigated whether their relatively high aerobic
cytotoxicity and their relatively low hypoxic selectivity in vitro are associated with
topoisomerases I and II (
Topo I and II ) inhibition . -
pubmed
These results suggest that
topoisomerase inhibition accounts for NLAs aerobic
toxicity . -
pubmed
Significant association of
DRD1 with
nicotine dependence . -
pubmed
In this study , we examined five single - nucleotide polymorphisms ( SNPs ) within or near the
dopamine D ( 1 ) receptor gene (
DRD1 ) for their association with
ND , which was assessed by smoking quantity ( SQ ) , the Heaviness of Smoking Index ( HSI ) , and the Fagerstrom Test for
ND ( FTND ) . -
pubmed
One isoform of
alpha1 - antitrypsin showed decreased glycosylation in
AD patients while another glycosylated isoform of an unassigned protein was up - regulated . -
pubmed
Protein expression levels of
alpha1 - antitrypsin were decreased , while the protein levels of
apolipoprotein E and
clusterin were increased in
AD . -
pubmed
Pivotal role of
angiotensin II receptor subtype 1A in the development of two - kidney , one - clip
hypertension : study in
angiotensin II receptor subtype 1A knockout
mice . -
pubmed
OBJECTIVE : The present study was performed to examine in two - kidney , one - clip ( 2K1C ) Goldblatt
hypertensive mice : first , the relative contribution of
angiotensin II receptor subtypes 1A (
AT ( 1A ) ) and 1B (
AT ( 1B ) ) ; second , the role of
angiotensin II type 2 ( AT ( 2 ) ) receptors in the development of
hypertension in wild - type ( AT(1A)+/+ ) and
AT ( 1A ) receptor knockout ( AT(1A)-/- )
mice ; and third , the role of increased
nitric oxide synthase activity in counteracting the
hypertensinogenic action of
angiotensin II in this model . -
pubmed
CONCLUSION : The present data support the critical role of
AT ( 1A ) receptors in the development of 2K1C
hypertension , whereas
AT ( 1B ) receptors play only a minor role in blood pressure regulation in this model of
angiotensin II - dependent
hypertension . -
pubmed
Activation of
AT ( 2 ) receptors does not play an antagonistic role in the
AT ( 1 ) receptor - mediated
hypertensinogenic actions of
angiotensin II in this model . -
pubmed
Finally , enhanced
nitric oxide synthase activity plays a protective role by counteracting the vasoconstrictor influences of
angiotensin II in 2K1C
hypertensive mice . -
pubmed
BACKGROUND AND PURPOSE :
Superoxide (
O ( 2 )(*- ) ) , derived from
nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase , is associated with
acute respiratory distress syndrome (
ARDS ) . -
pubmed
ACS6 may be effective in treating
ARDS through both elevation of
cAMP and inhibition of
phosphodiesterase type 5 activity . -
pubmed
METHODS :
Fos immunoreactivity revealing neuronal activation , and degenerating neurons labeled by
Fluoro - Jade B ( FJB ) histochemistry were analyzed on the first day after onset of
seizures lasting 3 h. Subpopulations of
gamma - aminobutyric acid (
GABA)ergic cells were characterized with double Fos -
parvalbumin immunohistochemistry . -
pubmed
In Proechimys , almost all reticular nucleus neurons were
Fos - positive at 24 h. DISCUSSION : At variance with laboratory
rats ,
pilocarpine - induced protracted
seizures elicit in Proechimys limited neuronal death , and marked and long - lasting Fos induction in excitatory and inhibitory cortical and thalamic cell subsets . -
pubmed
CONCLUSION : The
visceral hyposensitivity induced by REM sleep deprivation may be associated with the increase of expression of
CNS endocannabinoid receptor and decrease of its metabolism . -
pubmed
In
haemophilia A , linkage analysis with
coagulation factor VIII ( F8 ) intragenic and/or neighbouring extragenic short tandem repeats ( STRs ) enables indirect tracking F8 pathogenic allelic variant - carriers . -
pubmed
Thrombin generation in vitro in the presence of by - passing agents in siblings with severe
haemophilia A. -
pubmed
Previous data have shown an inter -
individual difference in the
thrombin generating capacity in vitro as well as phenotypic bleeding pattern among patients with severe
haemophilia A (
FVIII : C activity below 1 % ) . -
pubmed
Dexamethasone treatment inhibits
VEGF production via suppression of
STAT3 in a
head and neck cancer cell line . -
pubmed
MicroRNA-34a is induced via
p53 during
cisplatin nephrotoxicity and contributes to cell survival . -
pubmed
In vivo , miR-34a induction by
cisplatin was abrogated in
p53 - deficient mice , a result that further confirms a role for
p53 in miR-34a induction during
cisplatin nephrotoxicity . -
pubmed
Collectively , the results suggest that miR-34a is induced via
p53 during
cisplatin nephrotoxicity and may play a cytoprotective role for cell survival . -
pubmed
METHODS : The study population included 504 subjects , 418 males and 86 females , aged 10 - 23 years old who have emigrated from Albania to Pogoniani - Greece and participated voluntarily in vaccination programmes against
Hepatitis B. The serum samples were examined with enzyme immune assays for the immunological markers
HBsAg , anti -
HBc ,
anti - HBs and anti -
HCV . -
pubmed
Effects of
Panax ginseng on
tumor necrosis factor - alpha - mediated
inflammation : a mini - review . -
pubmed
Proinflammatory cytokines ,
chemokines ,
adhesion molecules and mediators of
inflammation including
inducible nitric oxide synthase ,
cyclooxygenase-2 and
nitric oxide orchestrate the inflammatory response . -
pubmed
The therapeutic potential of ginseng on
TNF - alpha - mediated
inflammatory diseases is also discussed . -
pubmed
METHODS AND RESULTS : Using data from the Third National Health and Nutrition Examination Survey , we evaluated the associations between
iron deficiency ,
hemoglobin ,
C - reactive protein (
CRP ) , and all - cause and cardiovascular mortality in 574 adults with self - reported
heart failure . -
pubmed
Iron deficiency was defined in both absolute and functional terms as a
ferritin level & lt;100 mug / L or between 100 and 299 mug / L if the
transferrin saturation was & lt;20 % . -
pubmed
Iron deficiency was present in 61.3 % of participants and was associated with reduced mean
hemoglobin ( 13.6 versus 14.2 g / dL , P=0.007 ) and increased mean
CRP ( 0.95 versus 0.63 mg / dL , P=0.04 ) . -
pubmed
In age- and sex - adjusted Cox proportional hazards models ,
hemoglobin ,
CRP , and
transferrin saturation but not
iron deficiency were significantly associated with all - cause and cardiovascular mortality . -
pubmed
CONCLUSIONS :
Iron deficiency is common in
heart failure and is associated with decreased
hemoglobin and increased
CRP . -
pubmed
Regulated
ATF5 loss - of - function in adult
mice blocks formation and causes regression / eradication of
gliomas . -
pubmed
Our past findings indicated that
glioblastoma cells , but not neurons or glia , require the transcription factor
ATF5 (
activating transcription factor 5 ) for survival . -
pubmed
However , it was unknown whether interference with
ATF5 function can prevent or promote regression / eradication of
malignant gliomas in vivo . -
pubmed
In this model , d / n -
ATF5 expression is controlled by
doxycycline and the promoter for
GFAP , a marker for stem / progenitor cells as well as
gliomas . -
pubmed
Endogenous
gliomas were produced with high efficiency by
retroviral delivery of
platelet - derived growth factor ( PDGF )- B and
p53 - short hairpin RNA ( shRNA ) in adult bi - transgenic
mice in which expression of d / n -
ATF5 was spatially and temporally regulated . -
pubmed
Induction of d / n -
ATF5 before delivery of
PDGF - B /
p53 - shRNA virus greatly reduced the proportion of
mice that formed
tumors . -
pubmed
Moreover , d / n -
ATF5 induction after
tumor formation led to regression / eradication of detectable
gliomas without evident damage to normal brain cells in all 24
mice assessed . -
pubmed
OBJECTIVE : To identify the
IgE - binding epitopes in the allergen
Der p 1 of main house dust mites , which can be recognized by the specific
IgE in the sera from
allergic individuals , and obtain a hypoallergen derived from the T - B epitope fused peptide for potential use in specific immunotherapy ( SIT ) . -
pubmed
It is shown that
bortezomib affects the amount of
MRP1 gene mRNA , relocating the multifunctional protein
YB-1 , dependent on
Akt activity , from cytoplasm to nuclei of
MCF-7 breast cancer cells . -
pubmed
Anti - neutrophil cytoplasmic antibodies ( ANCA ) specific for one or several antigens : useful markers for subtypes of
ulcerative colitis and associated
primary sclerosing cholangitis . -
pubmed
This study analyzed specificity of
anti - neutrophil cytoplasmic antibodies ( ANCA ) in
IBD patients and its clinical significance . -
pubmed
RESULTS :
pANCA were more frequently present in
UC than in
CD patients ( p<0.001 ) . -
pubmed
ANCA titer correlated with the disease activity only in
UC patients ( p<0.05 ) . -
pubmed
UC patients more frequently had two or more
ANCA specificities compared to
CD patients ( p<0.01 ) . -
pubmed
Multi - specific ANCA with ANA and
ASMA had sensitivity of 67 % for
PSC . -
pubmed
Multi - specific ANCA with ANA and
ASMA could be markers for
PSC . -
pubmed
ANCA specific to several antigens may worsen
inflammation by reducing antimicrobial capacity of
neutrophil proteases and cationic proteins . -
pubmed
The aim of this study was to assess the role of fungal
FBE and ME in colon
carcinogenesis . -
pubmed
Factors associated with OS were
bisphosphonates use ( HR = 0.5 , p = 0.008 ) , elevated pre - treatment
alkaline phosphatase ( HR = 2.9 , p = 0.003 ) and
sunitinib induced
HTN ( HR = 0.63 , p<0.0001 ) . -
pubmed
HIV disease - related factors associated with greater volume abnormalities included
CD4 cell count nadir , clinical staging , history of
AIDS - defining events ,
infection age , and current age . -
pubmed
The odds ratio for
VF was markedly higher in subjects in the highest
S1P quartile category compared with those in the lowest
S1P quartile category after adjustment for confounders ( odds ratio 9.33 , 95 % confidence interval 2.68 - 32.49 ) . -
pubmed
RESULTS : Only 1 % of erythrocytes were recovered in
LRP without the
hemolysis of erythrocytes . -
pubmed
Patients with
TB usually have high titers of specific
IgG ; however , the
carbohydrate associated with
Fc - IgG usually lacks
galactose . -
pubmed
To assess the effect of this abnormal
IgG in
murine pulmonary TB , we evaluated the specificity of recognition to
Mycobacterium tuberculosis antigens in vitro and protective effects in vivo comparing
human intravenous immunoglobulin (
IVIg ) and IVIg treated with an
endoglycosidase to remove the glycan residues ( EndoS - treated IVIg ) . -
pubmed
Altogether , our results show that repeated
MDMA exposure causes strong neural and behavioral adaptations and that inhibitory feedback mediated by
alpha ( 2A )- adrenergic and 5 - HT ( 1A ) autoreceptors has an important role in the physiopathology of
addictive behaviors . -
pubmed
Firstly , we found that miR-452 directly regulates the expression of
thyroid hormone receptor
TRbeta1 in
renal cancer cells . -
pubmed
Monocyte chemotactic protein-1 -2518 gene polymorphism and susceptibility to
spinal tuberculosis . -
pubmed
BACKGROUND AND AIMS :
Monocyte chemotactic protein-1 (
MCP-1 ) gene polymorphisms play important roles in regulating immunological reactions and may be associated with
pulmonary tuberculosis . -
pubmed
However , the relationship between the
MCP-1 -2518 gene polymorphism and susceptibility to
spinal tuberculosis remains unknown . -
pubmed
We undertook this study to investigate the relationships between
MCP-1 promoter 2518 genotype frequency and allele polymorphisms and susceptibility to
spinal tuberculosis in a Chinese Han population . -
pubmed
MCP-1 -2518 GG genotype was significantly associated with the onset of
spinal tuberculosis ( OR = 2.306 , 95 % CI = 1.273 - 4.178 ) . -
pubmed
The G and A allele frequencies were 61.5 % and 38.5 % , respectively , in the case group , and 52.1 % and 47.9 % in the control group ( p & lt;0.05 ) , the allele " G " of
MCP-1 -2518 showed an association with an increased risk for
spinal tuberculosis : OR = 1.777 , 95 % CI = 1.053 - 2999 , p = 0.03 in the dominant model ; OR = 1.67 , 95 % CI = 1.097 - 2.544 , p = 0.016 in the recessive model . -
pubmed
CONCLUSIONS : The
MCP-1 -2518 GG genotype and presence of the G allele may be associated with susceptibility to
spinal tuberculosis in the Chinese Han population . -
pubmed
STUDY DESIGN AND METHODS : A
patient with
beta - thalassemia intermedia and hereditary persistence of fetal
hemoglobin presented for peripheral blood stem cell collection for autologous transplant for
myeloma . -
pubmed
[ A multicenter study on the validation of conversion factor for the conversion of
BCR -
ABL (
P210 ) transcript levels to the international scale in
chronic myeloid leukemia ] . -
pubmed
OBJECTIVE : To validate the
conversion factor ( CF ) for the conversion of
BCR -
ABL (
P210 ) transcript levels to the international scale in
chronic myeloid leukemia (
CML ) . -
pubmed
CONCLUSION : Validation of CF examined the stability of the detection of
BCR -
ABL (
P210 ) transcript levels , which was necessary for the valid conversion of
BCR -
ABL (
P210 ) transcript levels to the international scale in
CML . -
pubmed
Here , we describe two genes ,
Deformed epidermal autoregulatory factor 1 (
Deaf1 ) and
Adenosine A1 receptor (
Adora1 ) , that are differentially expressed and alternatively spliced in the pancreatic lymph nodes or islets of NOD
mice and
T1D patients to form dominant - negative non - functional isoforms . -
pubmed
Loss of
Deaf1 function leads to reduced peripheral tissue antigen expression in lymph node stromal cells and may contribute to a breakdown in peripheral tolerance , while reduced
Adora1 function results in an early intrinsic alpha cell defect that may explain the
hyperglucagonemia and resulting beta cell stress observed prior to the onset of
diabetes . -
pubmed
Since
cinnarizine is a well - tolerated
calcium channel blocker which has acceptable effect on both
vertigo and
migraine headache , we carried out this study to evaluate the efficacy and safety of this medication in
vestibular migraine and also
migraine with brainstem aura associated with
vertigo . -
pubmed
Tumor necrosis factor - alpha inhibitors alleviation of experimentally induced
neuropathic pain is associated with modulation of
TNF receptor expression . -
pubmed
We recently demonstrated that
tumor necrosis factor - alpha receptor (
TNFR ) levels in the spinal cord correlate with
pain sensation in herniated disc
patients in a
rat chronic constriction injury (
CCI ) model . -
pubmed
By using the sciatic nerve CCI model , we studied the effect of anti -
TNF - alpha treatment on recovery from
hypersensitivity and
TNFR expression in the dorsal root ganglion ( DRG ) and dorsal horn ( DH ) . -
pubmed
Anti -
TNF - alpha treatment resulted in a significant alleviation of
pain . -
pubmed
Treated
animals that showed a & gt;=50 % alleviation of
pain exhibited a significantly reduced
TNF R1 / R2 mRNA ratio compared with treated
animals that recovered less well . -
pubmed
These results demonstrate that attenuation of
TNFR expression is associated with recovery from
nerve injury and suggest that this may be one of the working mechanisms of anti -
TNF therapies . -
pubmed
Alzheimer ' s disease is a progressive
neurodegenerative disorder that is characterized by extensive deposition of fibrillar amyloid - beta (
Abeta ) in the brain . -
pubmed
Nonetheless , functional
p53 has been observed in
cervical cancer . -
pubmed
HPV encodes an
E6 oncoprotein that degrades the
tumor suppressor
p53 and abrogates cell cycle checkpoints . -
pubmed
Nonetheless , functional
p53 has been observed in
cervical cancer . -
pubmed
Histone
H2B ubiquitination at
lysine 120 (
H2Bub1 ) is regulated by
RNF20 , an E3 ubiquitin ligase that is altered in many
tumor types . -
pubmed
The
BCR - FS rate of
patients with pT2+category
tumors was significantly higher than that with pT3a category
tumors with
PSM but not significantly different from that with pT3a category
tumors without
PSM . -
pubmed
This study showed that these nanoparticles were stored as non - toxic
iron compounds :
maghemite oxide or
ferritin , which is promising for MRI detection of
atherosclerotic plaques in clinics using these USPIOs . -
pubmed
The Alliance for Clinical Trials in Oncology cooperative group has designed a phase III neoadjuvant clinical trial ( ALTERNATE trial ) which randomizes
women with cT2 - 4 N0 - 3 M0
ER+/
Her2- invasive
breast cancer to either
anastrozole ,
fulvestrant or its combination to assess a biomarker - driven treatment strategy to identify
women with a low risk of
disease recurrence . -
pubmed
Bevacizumab - resistant
FGBR pancreatic cancer cells were treated in vitro with bevacizumab , the recombinant
human IL1 receptor antagonist anakinra , the monoclonal antibody against
TGFbeta receptor type II TR1 , and a novel recombinant antibody binding
CXCR1 / 2 ligands . -
pubmed
Consistently , the combination of these agents with bevacizumab reduced the
FGBR tumor burden and significantly prolonged
mice survival compared with bevacizumab in monotherapy . -
pubmed
Tumors from
mice receiving the combination treatment showed significantly lower expression of
IL6 and phosphorylated
SMAD2 , higher expression of
E - cadherin and lower levels of
vimentin , and a significantly lower infiltration by
CD11b cells compared with bevacizumab - treated controls . -
pubmed
This study suggests that inhibition of
IL1 ,
CXCR1 / 2 , and
TGFbeta signaling pathways is a potential therapeutic approach to modulate the acquired resistance to anti -
VEGF treatment by reversing epithelial - mesenchymal transition and inhibiting
CD11b proangiogenic myeloid cells '
tumor infiltration . -
pubmed
The
SAPAP3 knockout ( KO ) transgenic
mouse was developed as an
animal model of
OCD and related disorders (
OCRD ) . -
pubmed
METHODS : Striatal and medial frontal cortex 9.4 Tesla proton spectra were acquired from young adult
SAPAP3 KO and wild - type control
mice to determine whether KO
mice have
metabolic and neurochemical abnormalities . -
pubmed
Importance of adipocyte
cyclooxygenase-2 and
prostaglandin E2 - prostaglandin E receptor 3 signaling in the development of
obesity - induced
adipose tissue inflammation and
insulin resistance . -
pubmed
We examined the involvement of adipocyte
cyclooxygenase-2 (
COX-2 ) and
prostaglandin E2 ( PGE2 )- prostaglandin E receptor ( EP ) 3 - mediated signaling during
hypertrophy and
hypoxia in the development of
obesity - associated adipose tissue ( AT )
inflammation and
insulin resistance . -
pubmed
The experiments were conducted with high - fat diet ( HFD)-induced
obese rats , db / db
mice ,
human subjects , and
3T3 - L1 and the
human Simpson - Golabi - Behmel syndrome (
SGBS ) adipocytes ; the groups were treated with selective inhibitors of
COX-2 [
celecoxib 30 mg / kg , half maximal inhibitory concentration ( IC50 ) 0.04 microM ] and
EP3 (
L-798106 100 microg / kg , IC50 0.5 microM ) or a short interfering RNA . -
pubmed
There were strong , positive correlations between adipocyte
COX-2 and
EP3 gene expressions and the AT
TNF - alpha and
monocyte chemotactic protein-1 contents and the homeostatic model assessment for
insulin resistance in HFD - induced
obese rats , as well as body mass index in
human subjects . -
pubmed
Treatment with
COX-2 and
EP3 inhibitors significantly reversed AT inflammatory gene and protein expressions ( -50 % ) and
impaired glucose and insulin tolerance in db / db
mice . -
pubmed
Targeting inhibition of adipocyte
COX-2 and
EP3 during
hypertrophy and
hypoxia reversed the release of the augmented proinflammatory adipokines and the diminished
adiponectin and also suppressed
NF - kappaB and
hypoxia - inducible factor-1alpha transcription activation . -
pubmed
These findings suggest that adipocyte
COX-2 PGE2 -
EP3 - mediated signaling is crucially involved in the development of
obesity - associated AT
inflammation and
insulin resistance.-Chan , P.-C. , Hsiao , F.-C. , Chang , H.-M. , Wabitsch , M. , Hsieh , P. S. Importance of adipocyte
cyclooxygenase-2 and
prostaglandin E2 - prostaglandin E receptor 3 signaling in the development of
obesity - induced
adipose tissue inflammation and
insulin resistance . -
pubmed
Prognostic implications of
epithelial to mesenchymal transition related proteins (
E - cadherin ,
Snail ) and
hypoxia inducible factor 1alpha in
endometrioid endometrial carcinoma . -
pubmed
Recently ,
hypoxia and
hypoxia - inducible factor 1alpha (
HIF-1alpha ) signaling pathway were identified to have an essential role in the regulation of EMT phenotype . -
pubmed
The aim of the study was to evaluate the prognostic impact of EMT - related proteins (
E - cadherin ,
Snail ) and
HIF-1alpha in
endometrioid endometrial carcinoma (
EEC ) among Egyptian women . -
pubmed
Immunohistochemical evaluation of
E - cadherin ,
Snail , and
HIF-1alpha expression was performed using 50 cases of
EEC . -
pubmed
The frequency of immunopositivity for
E - cadherin ,
Snail , and
HIF-1alpha in our cases of
EEC was 82 % , 28 % , and 66 % , respectively . -
pubmed
E - cadherin and
Snail have a predictive value in
EEC . -
pubmed
In conclusion , the current study reveals that both
Snail and
HIF-1alpha expressions are significantly associated with poor prognosis in
EEC ; however ,
E - cadherin expression is considered a marker of good prognosis . -
pubmed
E - cadherin and
Snail expression has a predictive value in
EEC management . -
pubmed
ABCA1 and
ABCG1 gene expression positively correlated with
obesity indicators such as body mass index ( BMI ) ( r=0.522 , p=0.004 ; r=0.594 , p=0.001 , respectively ) and waist circumference ( r=0.403 , p=0.033 ; r=0.474 , p=0.013 , respectively ) . -
pubmed
The development of
obesity is associated with decreased IAT levels of
RORa and
LXRb mRNA ( p=0.016 and p=0.002 , respectively ) . -
pubmed
These data suggest that the nuclear factor
RORa can play a significant role in the regulation of
cholesterol metabolism and control IAT expression of
ABCA1 and
ABCG1 , while the level of IAT
LXRb gene expression may be an important factor associated with the development of
obesity . -
pubmed
De novo
ALK kinase domain mutations are uncommon in kinase inhibitor - naive
ALK rearranged
lung cancers . -
pubmed
INTRODUCTION :
Anaplastic lymphoma kinase ( ALK ) rearranged lung adenocarcinomas are responsive to the multitargeted
ALK inhibitor
crizotinib . -
pubmed
However , the presence of
ALK mutations in
crizotinib - naive
tumors has not been widely reported and it is unclear if de novo
ALK mutations affect the response to
crizotinib . -
pubmed
METHODS : We analyzed preclinical models of
ALK rearranged lung cancers that were sensitive / resistant to
ALK inhibitors , probed our institutional and other
lung cancer databases for
tumors with
ALK kinase domain mutations , and evaluated
tumor response to
crizotinib . -
pubmed
Previous
ALK rearranged
lung cancer cohorts did not report
ALK kinase mutations in inhibitor - naive
tumors . -
pubmed
We identified one TKI - naive
ALK rearranged
tumor with an
ALK kinase domain mutation :
ALK - S1206F ( mutations at
ALK - S1206 shifted
crizotinib inhibitory curves only minimally in preclinical models ) . -
pubmed
The never smoker whose
tumor harbored de novo
EML4 -
ALK - E5;
A20+
ALK - S1206F only achieved a 4 - month radiographic response to
crizotinib 250 mg twice daily . -
pubmed
CONCLUSIONS : Combining data from our and prior cohorts ,
ALK kinase domain mutations were uncommon events ( & lt;3 % of cases ) in
ALK inhibitor - naive
ALK rearranged
lung adenocarcinomas but their effect on intrinsic resistance to
ALK inhibitors should be better evaluated . -
pubmed
RORgammat is a master transcription factor of Th17 cells and considered as a promising drug target for the treatment of
autoimmune diseases . -
pubmed
Whereas
Tiam1 genetic deficiency weakens
IL-17A expression partially and inhibits the development of experimental
autoimmune encephalomyelitis (
EAE ) , deletion of
Rac1 in T cells exhibits more robust effects on Th17 cells and
EAE . -
pubmed
The clinical relevance of these findings is emphasized by pharmacological targeting of
Rac1 that suppresses both
murine and
human Th17 cells as well as
EAE . -
pubmed
Thus , our findings highlight a regulatory pathway of
Tiam1 /
Rac1 in Th17 cells and suggest that it may be a therapeutic target in
multiple sclerosis . -
pubmed
RESULTS AND CONCLUSIONS : Abundant evidence has demonstrated that
Bregs play a regulatory role in inflammatory , autoimmune , and
tumor diseases , and regulatory B cells play different roles in different diseases , but future work needs to determine the mechanisms by which
Bregs are activated and how these cells affect their target cells . -
pubmed
Chicory inulin ameliorates
type 2 diabetes mellitus and suppresses
JNK and
MAPK pathways in vivo and in vitro . -
pubmed
CONCLUSION : Our study demonstrates that
chicory inulin , as a nutritional supplement , may be beneficial for the
patients with
type 2 diabetes mellitus , and the metabolism - modulatory effect seems to be related with the inhibition of
JNK and
P38 MAPK pathways . -
pubmed
We determined the involvement of afferent sensory neurons ,
calcitonin - gene - related peptide (
CGRP ) , lipid peroxidation , and
nitric oxide (
NO ) biosynthesis in gastroprotection of
H2S - releasing
NaHS and
CO - releasing
tricarbonyldichlororuthenium ( II ) dimer (
CORM-2 ) against
aspirin - induced
injury . -
pubmed
Particularly ,
lupane - type
triterpenes have shown great ability to modulate multiple
cancer - related signaling pathways and processes , including
NF - kappaB , Wnt /
beta - catenin ,
PI3K /
Akt , apoptosis , and many other routes related to proliferation or cell death , which are uncontrolled in
malignant tumors . -
pubmed
Expression of
claudin 1 ,
claudin 4 , and
claudin 7 in
colorectal cancer and its relation with
CLDN DNA methylation patterns . -
pubmed
Altered
claudin expression has been described in
colon , prostatic , ovarian , and breast carcinoma . -
pubmed
We aimed our study to investigate whether
claudin protein expression and methylation of
CLDN can influence the tumorigenesis of
colorectal cancer . -
pubmed
Immunohistochemical staining was used to study protein expression in both
tumor and the adjacent
nonneoplastic mucosa of
claudin 1 , 4 , and 7 . -
pubmed
To detect the DNA methylation pattern of
CLDN1 , 4 , and 7 , genomic DNA was extracted from both the
tumor and the adjacent
nonneoplastic mucosa . -
pubmed
Cell membrane staining intensity of all
claudins was found significantly lower in
colorectal cancer tissues when compared to paired
normal mucosa ( p & lt;= 0.001 ) . -
pubmed
In
normal mucosa , cytoplasm showed no staining for
claudins in any patient , whereas in paired
colorectal cancer tissues , significant cytoplasmic staining appeared both for
claudin 1 ( p = 0.04 ) and
claudin 4 ( p = 0.01 ) . -
pubmed
Tumor samples were significantly hypomethylated in
CLDN1 ( p & lt ; 0.05 ) . -
pubmed
In conclusion , our results show that
CLDN1 is significantly hypomethylated in
tumor samples and that the membrane staining intensity for
claudin 1 , 4 , and 7 is significantly lower in
colorectal cancer tissues than in adjacent
nonneoplastic tissue . -
pubmed
Colorectal cancer cells showed dystopic cytoplasmic location of
claudins . -
pubmed
The
CCL2 /
CCR2 axis is also involved in pathological processes such as
tumor growth and metastasis and hence is currently considered as an important drug target . -
pubmed
BACKGROUND : The World Health Organization ( WHO ) defines atypical
pituitary adenomas as
tumours with a
MIB-1 labelling index & gt;=3 % ,
p53 positivity and increased mitotic activity . -
pubmed
Anti - citrullinated Protein Antibodies (
ACPA ) are excellent markers for
Rheumatoid arthritis (
RA ) and are postulated to have a pathogenic role in the disease process . -
pubmed
A multistep model for the evolution of the ACPA response in
RA was proposed in which an initial break of tolerance causes , as " first hit " , " silent " production of
ACPA without any clinical symptoms . -
pubmed
The model further proposes that the ACPA immune response matures upon a certain ( unknown ) trigger , a " second hit " , which leads to epitope spreading , an increase in
ACPA titres and extended isotype usage before clinical
RA manifestations . -
pubmed
This review , therefore , describes the current knowledge about
ACPA Fab glycosylation in the pathogenesis of
RA . -
pubmed
Modifications of
BDNF in plasma and/or in serum are associated with neurodegenerative and
psychiatric disorders ,
cardiovascular diseases ,
metabolic syndrome and with mortality risk . -
pubmed
Porphyromonas Gingivalis Elevated
High - Mobility Group Box 1 Levels After
Myocardial Infarction in
Mice . -
pubmed
High mobility group box 1 (
HMGB1 ) is a nuclear protein released from
necrotic cells , inducing inflammatory responses . -
pubmed
Due to
tissue damage and
necrosis of cardiac cells following
myocardial infarction (
MI ) ,
HMGB1 is released , activating an inflammatory reaction . -
pubmed
The level of
HMGB1 protein in the P.g.-inoculated
MI group was significantly higher than in the PBS - injected
MI group on day 5 , but not on day 14 . -
pubmed
Immunohistochemistry analysis revealed that
HMGB1 was mainly expressed in cardiomyocytes , immune cells , and vascular endothelial cells in the PBS - injected
MI group , while
HMGB1 was seen broadly in degenerated cardiomyocytes , extracellular fields , immune cells , and vascular endothelial cells in the P.g.-inoculated
MI group . -
pubmed
A significant increase in the number of
HMGB1 positive cells was observed in the P.g.-inoculated
MI group compared to the PBS - injected
MI group . -
pubmed
after
MI enhanced myocardial
HMGB1 expression . -
pubmed
There is a possible relationship between
periodontitis and post -
infarction myocardial inflammation through
HMGB-1 . -
pubmed
A higher P / F ratio and
SP - D level , lower
LDH and
ferritin levels , higher platelet counts , and anti -
MDA-5 antibody negativity are important prognostic markers in
patients with
CADM - associated RPIPs treated with
PMX - DHP . -
pubmed
Tumor Cell - selective Synergism of
TRAIL- and
ATRA - induced
Cytotoxicity in
Breast Cancer Cells . -
pubmed
The present work focused on tumor cell - inhibiting effects of a combination of
tumor necrosis factor - related apoptosis - inducing ligand (
TRAIL ) and
all trans retinoic acid (
ATRA ) in
breast cancer cells . -
pubmed
MATERIALS AND METHODS :
Breast cancer cell lines (
BT-20 ,
BT-474 ,
MDA - MB-231 ,
MDA - MB-436 ,
MDA - MB-453 ,
MCF-7 ,
SKBR3 ,
T47D ,
ZR-75 - 1 ) and the mammary epithelial cell line
MCF-10A were treated with
TRAIL and
ATRA alone and in combination . -
pubmed